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Sample records for ointments

  1. Critical evaluation of cadexomer-iodine ointment and povidone-iodine sugar ointment.

    Science.gov (United States)

    Noda, Yasuhiro; Fujii, Kiori; Fujii, Satoshi

    2009-05-01

    Topical iodine forms are used for infected and necrotic pressure ulcers. Despite antimicrobial advantages several potential disadvantages were observed with controversial results. To clarify the controversy, the reactivity of povidone-iodine (PI) sugar ointment and cadexomer-iodine (CI) ointment toward biological components was investigated. L-Tyrosine as a component of proteins and egg lecithin as a component of lipid membranes were reacted with forms of iodine. Furthermore, water absorption abilities of ointments were investigated. The reactions of PI sugar ointment and CI ointment with L-tyrosine were reversely dependent on iodine concentrations. CI ointment reacted with lecithin in an iodine concentration dependent manner, while PI sugar ointment reacted with lecithin in an iodine concentration independent steady manner. However, at the clinically relevant iodine concentration (0.1, w/v%) PI sugar ointment reacted efficiently with L-tyrosine and less efficiently with lecithin, while CI ointment reacted efficiently with lecithin and less efficiently with L-tyrosine. Water absorption rate constant was 29.9 mg/cm(2)/min(0.5) for PI sugar ointment and 15.3 for CI ointment. Water absorption capacity per weight over 24 h was 26% forPI sugar ointment and 76% for CI ointment [corrected]. These results suggest that PI sugar ointment and CI ointment have different characteristics for iodine reactivity and water absorption.

  2. 21 CFR 524.1484a - Neomycin sulfate ophthalmic ointment.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Neomycin sulfate ophthalmic ointment. 524.1484a... § 524.1484a Neomycin sulfate ophthalmic ointment. (a) Specifications. Each gram of the ointment contains 5 milligrams of neomycin sulfate equivalent in activity to 3.5 milligrams of neomycin base....

  3. 21 CFR 524.575 - Cyclosporine ophthalmic ointment.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Cyclosporine ophthalmic ointment. 524.575 Section... § 524.575 Cyclosporine ophthalmic ointment. (a) Specifications. Each gram of ointment contains 2 milligrams of cyclosporine. (b) Sponsor. See No. 000061 in § 510.600(c) of this chapter. (c) Conditions of...

  4. Structural rheology of a model ointment.

    Science.gov (United States)

    Pena, L E; Lee, B L; Stearns, J F

    1994-06-01

    A model ointment consisting of white petrolatum, mineral oil and microcrystalline wax was studied using rheology, microscopy and thermal techniques. Rheograms studied over a temperature range of 25-40 degrees C indicated that the overall rheogram shape changed little as the temperature increased. However, two inflections gradually disappeared as the temperature increased. Thermal optical analysis showed that the temperature range over which these inflection disappeared correlated with the melting transition of the components forming the secondary structure. Another series of rheograms obtained from ointments with different combinations of the raw materials showed the rheology of the ointment is primarily controlled by the white petrolatum and mineral oil and that the microcrystalline wax acts to build-up the structure by incorporating itself into the existing white petrolatum structure. Thermal optical analysis of comelts of the raw materials proved that the ointment network structure is essentially a recombination of the naturally occurring components in differing ratios. The knowledge obtained from these studies is applied to a discussion of the thermal and mechanical stresses encountered in the filling operation.

  5. Tacrolimus Ointment for Refractory Posterior Blepharitis.

    Science.gov (United States)

    Sakassegawa-Naves, Fernando Eiji; Ricci, Helena Maria Moraes; Moscovici, Bernardo Kaplan; Miyamoto, Daniela Akemi; Chiacchio, Brenda Biagio; Holzchuh, Ricardo; Santo, Ruth Muyuki; Hida, Richard Yudi

    2017-09-18

    This prospective, randomized, double-blind interventional case series was designed to evaluate the short-term efficacy of 0.03% tacrolimus ointment as a new therapeutic approach for refractory cases of posterior blepharitis. Forty eyes (20 patients) with posterior blepharitis refractory to previous treatment were randomized. Eighteen eyes (9 patients) were treated with 0.03% tacrolimus ointment and 20 eyes (10 patients) with placebo ointment twice daily. Patients were evaluated with a questionnaire and slit-lamp examination 14 days and 28 days after treatment, and symptoms and signs of blepharitis were compared to those observed at baseline. We could observe statistical difference in the outcome measurements of meibomian gland secretion, conjunctival hyperemia, telangiectasia of inferior lid, Rose Bengal, and fluorescein scoring for the study group. As for the symptoms score, we observed statistical difference in the symptoms scoring for pruritus and dry eye sensation in the tacrolimus group. This study suggests that topical administration of 0.03% tacrolimus ointment can improve some symptoms and some ocular surface status in patients with refractory posterior blepharitis.

  6. Rubbing Therapy with Ointment for Patella Strain in 42 Cases

    Institute of Scientific and Technical Information of China (English)

    SUN De-bin; ZHANG Wan-li; XIAO Yuan-chun

    2003-01-01

    Objective: The clinical effects of rubbing therapy with ointment in treating patella strain were observed. Method: Forty-two cases of patella strain were treated by local rubbing with ointment and the changes of the clinical symptoms were observed. Results: After 3 courses of treatment, the total effective rate was 95.2%.Conclusion: It is indicated that rubbing therapy with ointment has good effects in the treatment of patella strain.

  7. A study in Renaissance psychotropic plant ointments.

    Science.gov (United States)

    Piomelli, D; Pollio, A

    1994-01-01

    Various historical sources from the Renaissance--including transcripts of trials for witchcraft, writings on demonology and textbooks of pharmaceutical botany--describe vegetal ointments prepared by women accused of witchcraft and endowed with marked psychoactive properties. Here, we examine the botanical composition and the possible pharmacological actions of these ointments. The results of our study suggest that recipes for narcotic and mind-altering salves were known to Renaissance folk healers, and were in part distinct from homologous preparations of educated medicine. In addition, our study reveals an unexpected connection of these vegetal psychotropes with archaic chtonic beliefs, confirming the tight association between rituals and cults entered on the Underworld and the image of the Medieval witch.

  8. DESIGN AND MICROBIAL SCREENING OF HERBAL OINTMENT OF Phyllanthus amarus

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    John A Avbunudiogb

    2014-09-01

    Full Text Available Objective: Herbal medicines contribute in no small measure to health care the world over, especially for rural dwellers and developing countries. The extracts of Phyllanthus amarus have been reported to be medicinal. In this study, herbal ointment containing methanol extract of the aerial part of Phyllanthus amarus was formulated and evaluated for the pH and spreadability as well as its antimicrobial properties against some human pathogens: Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Aspergilus niger.Method: Pulverized dried leaves were extracted using methanol in ratio 1:4. Simple ointment BP was used as ointment base for dispersion of the plant extract. Parameters investigated include; spreadability, pH and zones of inhibition of extract and formulated ointment while chloramphenicol and fluconazole were used as controls.  The sensitivity of the organisms in ointment containing varying concentrations of the extract was also determined.Result: The pH of the ointment was 6.17 ± 0.9 and the spreadability was 120 ± 0.5. B. subtilis, P. aeruginosa and staph aureus were susceptible to ointment containing 0.1% w/v and 0.15% w/v, while E. coli and A. niger were resistant. The organisms were all susceptible to the ointment containing 0.2% w/w P. amarus.Conclusion: P. amarus ointment has good antimicrobial properties and can be used for the treatment of wounds and skin infection caused by these organisms.

  9. Effects of Manufacturing Conditions on Pharmaceutical Properties of Petrolatum Ointment.

    Science.gov (United States)

    Ashizuka, Yuki; Horisawa, Eijiro

    2016-08-01

    Oleaginous white petrolatum ointment (WP ointment) is one of the most commonly used dosage forms in the preparation of topical products. In general, WP ointments containing medium chain fatty acid triglycerides (MCT) are manufactured through a process of melting, mixing, agitating, and cooling. To investigate the pharmaceutical properties of WP ointments in greater detail, we examined manufacturing factors which could potentially influence the pharmaceutical properties of the finished product. WP ointment samples containing 10% MCT were stirred with a homogenizer and a paddle mixer at 65°C, then the homogenizer was stopped. Next, the paddle-mixer was stopped at several planned temperature points at which different samples were taken. Each sample was then cooled under the following planned conditions: rapid-cooling [-50°C/h] and slow-cooling [-7.5°C/h]. The pharmaceutical properties of each WP ointment sample, along with the appearance (Optical/digital microscope), hardness (Rheometer), and bleeding ability (100 Mesh wire-net cone) were measured. Then, release profiles were performed with a WP ointment using the model active ingredient Vitamin D. As a result, high hardness, low bleeding ability and low release profile were observed in the WP ointment samples that were manufactured under the condition of stopping the paddle-mixer at 40°C. However, the influence of cooling speed was observed to affect only hardness. Through optical microscopic observation, it was found that the appearance of WP ointment samples differed depending on the conditions under which they were manufactured. In this study, it was clear that the pharmaceutical properties of WP ointment samples were particularly influenced by the paddle-mixer stopping temperature.

  10. Topical retapamulin ointment, 1%, versus sodium fusidate ointment, 2%, for impetigo : A randomized, observer-blinded, noninferiority study

    NARCIS (Netherlands)

    Oranje, Arnold P.; Chosidow, Olivier; Sacchidanand, Sarvajnamurthy; Todd, Gail; Singh, Krishan; Scangarella, Nicole; Shawar, Ribhi; Twynholm, Monique

    2007-01-01

    Background: Retapamulin is a novel pleuromutilin antibacterial developed for topical use. Objective: To compare the efficacy and safety of retapamulin ointment, 1% (twice daily for 5 days), with sodium fusidate ointment, 2% (3 times daily for 7 days), in impetigo. Methods: A randomized (2: 1 retapam

  11. TACROLIMUS OINTMENT FOR TREATMENT OF VKC

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    Navin Chandra

    2017-05-01

    Full Text Available BACKGROUND Vernal Keratoconjunctivitis (VKC is a bilateral recurrent chronic allergy inflammatory disorder of ocular surface, which is seasonally exacerbated mostly involving tarsal and bulbar conjunctiva in chronic and severe cases involves cornea as well. Affects mostly children and young adults with male predominance. Tacrolimus (FK-506 is a highly potent immune modulatory agent produced by the fungus Streptomyces tsukubaensis. MATERIALS AND METHODS This prospective, nonrandomised case series enrolled 20 patients (40 eyes with severe VKC who were treated with tacrolimus 0.1% ointment. The mean age of the patients was 18.25 ± 4.2 years (range, 9-31 years. Each patient completed a follow-up period of at least 12 months. The main outcome measure was the clinical response to treatment. RESULTS Significant improvements in clinical signs and symptoms were achieved in all patients 6 weeks after starting treatment with topical tacrolimus. Treatment was gradually reduced with increasing intervals between applications. VKC recurred in all patients who attempted to discontinue treatment. No additional medications were required and no significant changes in visual acuity or refraction were documented. Five patients discontinued treatment due to a severe burning sensation and were excluded from the study. CONCLUSION Tacrolimus 0.1% ointment is a safe and effective treatment for VKC refractory to standard treatment and maybe used as a substitute for steroid treatments used to controlled-disease activity. However, adverse effects could cause poor patient compliance.

  12. COMPARATIVE STUDIES ON POVIDONE-IODINE OINTMENT AND GEL

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    T. Mangilal*, K. S. K. Rao Patnaik , R. Sivakumar , Y. Sudhakar and S. K. Basu

    2012-11-01

    Full Text Available Povidone-Iodine Ointment was prepared using polyethylene glycol base by fusion method and the gel was prepared using Poloxamer 407 as a gelling agent by cold process. The different characteristics of povidone-iodine ointment and gel were compared from the results obtained for assay and total, available and complex iodine contents. These values were comparable with marketed formulations. The formulations were tested for wound healing and antimicrobial activity. Wound healing studies show that the time taken for complete wound healing was slightly less for prepared povidone-iodine ointment and gel than the marketed preparations. Antimicrobial activity also found to be almost equal for the different formulations.

  13. Influence of drug loading and type of ointment base on the in vitro performance of acyclovir ophthalmic ointment.

    Science.gov (United States)

    Al-Ghabeish, Manar; Xu, Xiaoming; Krishnaiah, Yellela S R; Rahman, Ziyaur; Yang, Yang; Khan, Mansoor A

    2015-11-30

    The availability of in vitro performance tests such as in vitro drug release testing (IVRT) and in vitro permeation testing (IVPT) are critical to comprehensively assure consistent delivery of the active component(s) from semisolid ophthalmic drug products. The objective was to study the impact of drug loading and type of ointment base on the in vitro performance (IVRT and IVPT) of ophthalmic ointments using acyclovir as a model drug candidate. The in vitro drug release for the ointments was evaluated using a modified USP apparatus 2 with Enhancer cells. The transcorneal permeation was carried out using rabbit cornea on modified vertical Franz cells. The drug retention in cornea (DRC) was also determined at the end of transcorneal drug permeation study. The in vitro drug release, transcorneal drug permeation as well as DRC exhibited a proportional increase with increasing drug loading in the ointment. On comparing the in vitro drug release profile with transcorneal permeation profile, it appears that drug release from the ointment is controlling acyclovir transport through the cornea. Furthermore, enhanced in vitro transcorneal permeation relative to the in vitro drug release underscores the importance of the interplay between the physiology of the ocular tissue and ointment formulation. The results indicated that IVRT and IVPT could be used to discriminate the impact of changes in drug load and formulation composition of ophthalmic ointments.

  14. Evaluation of herbal ointment formulation of Milicia excelsa (Welw ...

    African Journals Online (AJOL)

    Ijeoma

    2013-05-22

    May 22, 2013 ... The wound healing effect of Milicia excelsa ointment was evaluated in ... treated rats showed abundant fibroblasts, mild collagenization, moderate macrophages and ... traditional healers in Uzo-Uwani in Nsukka area South.

  15. How to Use Eye Ointments and Gels Properly

    Science.gov (United States)

    ... be cloudy after using the ointment or gel Store medications out of reach of children Copyright 2013, American Society of Health-System Pharmacists. All rights reserved. This material may not be reproduced, displayed, modified, or distributed ...

  16. Investigation of physical and chemical stability of ointment with herbals.

    Science.gov (United States)

    Zdoryk, Oleksandr A; Khokhlova, Kateryna O; Georgiyants, Victoriya A; Vyshnevska, Liliia I

    2014-01-01

    The physical and chemical stability of a stock preparation ointment with active ingredients-herbal tinctures of calendula and arnica-for the treatment of hemorrhoids was studied. Evaluations for physical and chemical stability were performed initially and throughout the storage period. Physical stability of the ointment was assessed by means of visual observation in normal room light. Throughout the study period, the physical appearance of the ointment did not change. The chemical stability of the ointment was evaluated by means of a stability-indicating, thin-layer chromatography analytical technique. The shelf-life was found to be one month at 25 degrees C +/- 2 degrees C/60% RH and two months at 5 degrees C +/- 3 degrees C, when protected from light.

  17. [Treatment of phimosis with betamethasone ointment in children].

    Science.gov (United States)

    Lee, K S; Koizumi, T; Nakatsuji, H; Kojima, K; Yamamoto, A; Kawanishi, Y; Numata, A

    2001-09-01

    We evaluated the efficacy of betamethasone ointment in the treatment of childhood phimosis and determined the most effective concentration of betamethasone. Between August 1996 and May 2000, 69 patients (median age 3.0, range 0-12) presented to our department with severe phimosis (grade 4, Tsugaya's classification), and were enrolled in this study and treated with betamethasone ointment for 4 weeks. The ointment was applied on the narrowed preputial skin twice a day by parents. During the first week, parents were asked not to retract the foreskin. After this period, parents were encouraged to retract the foreskin gently and without intense tension. The concentration of betamethasone were 0.12%, 0.05% and 0.025%. If the patients become to be able to retract foreskin satisfactory, we consider the state as complete response. If he become to be able to retract to allow partial exposure of the glans, we consider the state as partial response. We compared the efficacy among each of the concentrations, and at 3 months after the end of the treatment, we also assessed the adverse effects and recurrence. The overall success rate was 85.5%. Success rates with 0.12%, 0.05% and 0.025% ointment were 96.8%, 82.8% and 55.6%, respectively (p = 0.0001). The 0.12% ointment was most effective. Recurrence was observed in 3 patients (4.3%). No adverse effects were observed in any of the patients. Treatment with betamethasone ointment is very effective, easy and safe. We recommend betamethasone ointment as the first treatment of choice for childhood phimosis.

  18. 21 CFR 524.1880 - Prednisolone-neomycin sulfate ophthalmic ointment.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Prednisolone-neomycin sulfate ophthalmic ointment... ANIMAL DRUGS § 524.1880 Prednisolone-neomycin sulfate ophthalmic ointment. (a) Specifications. Prednisolone-neomycin sulfate ophthalmic ointment contains 2 milligrams prednisolone and 5 milligrams...

  19. The treatment of balanitis xerotica obliterans with testosterone propionate ointment.

    Science.gov (United States)

    Pasieczny, T A

    1977-01-01

    Balanitis xerotica obliterans (BXO) and kraurosis penis are thought to be synonymous. Clinically and histopathologically they probably represent the same disease process as lichen sclerosus et atrophicus (LSA) but also involve the urethral mucosa. The treatment of choice is considered to be 2 1/2% testosterone propionate ointment which gives better results than strong corticosteroid applications, yet without their side effects.

  20. Efficacy and safety of methimazole ointment for patients with hyperthyroidism.

    Science.gov (United States)

    Wu, Xi; Liu, Hong; Zhu, Xixing; Shen, Jun; Shi, Yongquan; Liu, Zhimin; Gu, Mingjun; Song, Zhimin

    2013-11-01

    Oral methimazole has been widely used to treat hyperthyroidism, but its usage is restricted by its adverse systemic effects. The aim of this study was to investigate the efficacy and safety of methimazole ointment for the treatment of hyperthyroidism. One hundred forty-four subjects with hyperthyroidism were initially enrolled. These patients were initially divided into two groups and given the following treatments for 12 weeks: patients in group A received 5% methimazole ointment applied to the skin around the thyroid and an oral placebo; and patients in group B received methimazole tablets and placebo ointment. One hundred thirty-one subjects were included in the final analysis. Therapeutic efficacy was assessed via the levels of free triiodothyronine and thyroxine in the serum and by biweekly monitoring of the symptoms of thyrotoxicosis. Adverse effects were recorded. Fifty-nine (89.40%) patients in group A and 57 (87.69%) patients in group B were euthyroid and experienced alleviation of thyrotoxicosis symptoms (complete control; p>0.05). The median times required to achieve complete control for the patients in the two groups were 6.5 weeks and 6.4 weeks for groups A and B, respectively (p>0.05). Systemic adverse effects (e.g., rash, liver dysfunction, leucopenia, etc.) were significantly less common in group A (1.5%) than in group B (12.3%; phyperthyroidism.

  1. Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment

    Science.gov (United States)

    Blanchard, Catlyn; Brooks, Lauren; Ebsworth-Mojica, Katherine; Didione, Louis; Wucher, Benjamin; Dewhurst, Stephen; Krysan, Damian

    2016-01-01

    ABSTRACT Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus are commonly associated with biofilm-associated wound infections that are recalcitrant to conventional antibiotics. As an initial means to identify agents that may have a greater propensity to improve clearance of wound-associated bacterial pathogens, we screened a Food and Drug Administration-approved drug library for members that display bactericidal activity toward 72-h-established P. aeruginosa biofilms using an adenylate kinase reporter assay for bacterial cell death. A total of 34 compounds displayed antibiofilm activity. Among these, zinc pyrithione was also shown to reduce levels of A. baumannii and S. aureus biofilm-associated bacteria and exhibited an additive effect in combination with silver sulfadiazine, a leading topical therapeutic for wound site infections. The improved antimicrobial activity of zinc pyrithione and silver sulfadiazine was maintained in an ointment formulation and led to improved clearance of P. aeruginosa, A. baumannii, and S. aureus in a murine model of wound infection. Taken together, these results suggest that topical zinc pyrithione and silver sulfadiazine combination formulations may mitigate wound-associated bacterial infections and disease progression. IMPORTANCE Topical antimicrobial ointments ostensibly mitigate bacterial wound disease and reliance on systemic antibiotics. Yet studies have called into question the therapeutic benefits of several traditional topical antibacterials, accentuating the need for improved next-generation antimicrobial ointments. Yet the development of such agents consisting of a new chemical entity is a time-consuming and expensive proposition. Considering that drug combinations are a mainstay therapeutic strategy for the treatment of other therapeutic indications, one alternative approach is to improve the performance of conventional antimicrobial ointments by the addition of a well-characterized and FDA

  2. 21 CFR 524.1484d - Neomycin sulfate, hydrocortisone acetate, tetracaine hydrochloride ear ointment.

    Science.gov (United States)

    2010-04-01

    ..., tetracaine hydrochloride ear ointment. 524.1484d Section 524.1484d Food and Drugs FOOD AND DRUG..., tetracaine hydrochloride ear ointment. (a) Specifications. The product contains 5 milligrams of neomycin... a lesser degree, chronic otitis externa in dogs and cats. In treatment of ear canker and...

  3. 21 CFR 524.1883 - Prednisolone sodium phosphate-neomycin sulfate ophthalmic ointment.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Prednisolone sodium phosphate-neomycin sulfate... DOSAGE FORM NEW ANIMAL DRUGS § 524.1883 Prednisolone sodium phosphate-neomycin sulfate ophthalmic ointment. (a) Specifications. Prednisolone sodium phosphate-neomycin sulfate ophthalmic ointment...

  4. 21 CFR 524.1600b - Nystatin, neomycin, thiostrepton, and triamcinolone acetonide ophthalmic ointment.

    Science.gov (United States)

    2010-04-01

    ... conjunctivitis in cats and dogs and for infectious kerato-conjunctivitis (pink eye) in cattle. (2) It is to be administered as follows: (i) For conjunctivitis and keratitis: Apply one drop of ointment to the affected eye(s... infectious kerato-conjunctivitis: Apply small line of ointment to the affected eye(s) once daily....

  5. Optical Coherence Tomography Findings in Anterior Chamber Ointment Globule after Phacoemulsification

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    Ahmad M. Mansour

    2015-12-01

    Full Text Available We present 2 cases of anterior chamber ointment with evidence of progressive endothelial cell loss. In both cases, an anterior segment optical coherence tomography (OCT was similar to an OCT of a tobramycin-dexamethasone ointment placed on a pen tip. An anterior segment OCT also demonstrated the direct contact of the globule with the corneal endothelium. A gas chromatography/mass spectrometry analysis documented the similarity to tobramycin-dexamethasone ointment in 1 case. Anterior segment OCT can help in confirming the diagnosis. Corneal endothelial injury is a continuous process, and its clinical manifestation is related to the size of the globule, the initial endothelium count, and the duration of ointment contact, which is related to supine positioning. It is advisable to avoid ointments in the immediate postoperative period, especially in corneal wounds larger than 3 mm.

  6. Radiation recall dermatitis after docetaxel chemotherapy. Treatment by antioxidant ointment

    Energy Technology Data Exchange (ETDEWEB)

    Duncker-Rohr, Viola; Freund, Ulrich; Momm, Felix [Ortenau-Klinikum Offenburg-Gengenbach Lehrkrankenhaus der Albert-Ludwigs-Universitaet Freiburg i. Br., Radio-Onkologie, Offenburg (Germany)

    2014-05-15

    Radiation recall dermatitis (RRD) is an acute skin toxicity caused by different anticancer or antibiotic drugs within a former completely healed irradiation field. Predictive factors for RRD are not known and its mechanisms are not completely understood. A case of RRD induced by docetaxel and successfully treated by an antioxidant ointment (Mapisal {sup registered}) is presented here. Such an ointment might be useful not only in RRD therapy, but also in the treatment of high-grade dermatitis induced by radiotherapy and thus may contribute to the improvement of patients' quality of life and to the scheduled completion of cancer therapies. (orig.) [German] Die Strahlen-Recall-Dermatitis (RRD) ist eine akute Hauttoxizitaet, die durch verschiedene Chemotherapeutika oder Antibiotika innerhalb eines frueheren, komplett abgeheilten Bestrahlungsfelds hervorgerufen wird. Praediktive Faktoren fuer die RRD sind nicht bekannt und ihr Mechanismus ist nicht vollstaendig geklaert. Es wird ein Fallbericht einer durch Docetaxel induzierten RRD dargestellt, die erfolgreich mit einer antioxidativen Salbe (Mapisal {sup registered}) behandelt wurde. Solche Salben koennten nicht nur zur Therapie der RRD, sondern auch bei der Behandlung einer akuten Dermatitis waehrend der Strahlentherapie nuetzlich sein und damit zur Verbesserung der Lebensqualitaet der Patienten und zur planmaessigen Durchfuehrung der Tumortherapie beitragen. (orig.)

  7. Study of structural-mechanical properties of the ointment base

    Directory of Open Access Journals (Sweden)

    V. V. Rudenko

    2013-06-01

    Full Text Available The ENTRY. For the local treatment of surgical wounds basis of a medicine plays an important role in ensuring its therapeutic effect. Ointment framework depends on adequate frequency of applications, pharmacokinetics, therapeutic effect and absence/presence of side effects. Unjustifiable selected the basis of a medicinal product may cause not only the increase or reduction of the actions of the active substance, but also a total absence of it. The AIM of the WORK was to develop composition and technology of production of combined emulsion of a medicine for the treatment of surgical wounds that meet the modern medical-biological requirements. MATERIALS AND METHODS OF RESEARCH. Rheological studies carried out with the help of rotary viscometer with coaxial cylinders «Rheotest-2» (Germany. For the study took the hinge of a pilot sample. RESULTS AND THEIR DISCUSSION. Based on the biomedical requirements to create a combination of soft drugs for the treatment of wound healing we conducted research to establish ointments emulsion based on first order. As emulsifier of the first kind were used twin-80 and stearic acid, and emulsifier of the second kind - monostearat glycerin. For the comparative analysis was taken a comprehensive emulsifier No.1. It is established, that the use of a complex of emulsifiers stearic acid, emulsifier No.1 the highest structural-mechanical parameters have emulsion with the ratio of surface-active substances of 2.5 % and 5.5%, respectively. With the increase in the stearic acid emulsion was increase in the rheological parameters of the model for all shear rates. Also the composition of model samples at different ratios of emulsifier No.1 and the twin-80. Determined that the maximum value rheological parameters observed in the ratio of: emulsifier No.1-twin-80 (1:7. With the increase in the emulsions quantity of emulsifier No.1 rheological parameters increases sharply for all speeds of the shift. This non-linear dependence

  8. EVALUATION OF EFFECTS OF YAVAKSHAR OINTMENT ON ABHYANTAR ARSHA (INTERNAL PILES

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    Ukhalkar V. P.

    2013-08-01

    Full Text Available A disease which anguishes patient’s vital force or prana is called as Arsha according to Ayurveda. ‘Arsha’ is the gift of sedentary life style. One of its prime etiological factors is poor dietary habit which is unavoidable due to busy lifestyle. According to Sushruta the management of Arsha involves Aushadhi Chikitsa (conservative, Ksharkarma, Agnikarma and Shastrakarma (surgical. The ‘Dhatuvaigunya’ (Organic pathology local deformity of anal structures requires local treatment. Ksharkarma is the treatment having more effect but needed intervention of another person for therapy. Concept of application of Kshar by patient himself was presumed and for this purpose the ointment of Kshar was used. The study was carried out in eight groups i.e. A, B, C, D, E, F, G, H and each group consists of about 25 to 30 patients. The patients of I II and III degree piles and P/R bleeding were included in this study. At the end of trial it was found that the application of Yava Kshar ointment of 10% having base Siktha Tailam was more effective than other ointments (i.e. Yava Kshar ointment 5% base Siktha Tailam, Yava Kshar ointment 5% base petroleum jelly, Yava Kshar ointment 10% base petroleum jelly, Faktu ointment, Trifgol powder, plane Siktha Tailam and plane Petroleum jelly to reduced the P/R bleeding markedly in minimal period and to reduced the degree of haemorrhoids up to certain extent.

  9. [Preliminary report: the efficacy of clonidine hydrochloride ointment for postherpetic neuralgia].

    Science.gov (United States)

    Meno, A; Arita, H; Hanaoka, K

    2001-02-01

    The combination of clonidine hydrochloride, alpha 2-agonist, and opioid is useful for relieving the pain due to surgical procedures or cancer. The routes of administrations used are intravenous, intramuscular as well as intrathecal, epidural and transmucosal. However, transdermal clonidine has not been reported. We, therefore, investigated the analgesic effect of local administration of clonidine ointment. Ten patients with postherpetic neuralgia (PHN) were selected randomly. They were requested to fill out a questionnaire after applying clonidine ointment (150 micrograms/ointment 1 g) to the painful area. Items included in the questionnaire were: effectiveness, visual analog scale (VAS) before and after the administration of clonidine ointment, onset time, with or without allodynia and effectiveness to allodynia in the former case, side effects, and patients' background. Analysis of the answers indicates that clonidine ointment produced a satisfactory effect in nine patients. Onset time was within a few minutes in most patients. No patients suffered any side effects. Specific mechanism of effectiveness or the site affected has not been confirmed in this study, but considering the quick onset, it is presumed that the site where the ointment was applied was the very site that was affected. Clonidine hydrochloride ointment was effective in relieving the symptoms of PHN.

  10. Pharmacological Investigation of the Wound Healing Activity of Cestrum nocturnum (L. Ointment in Wistar Albino Rats

    Directory of Open Access Journals (Sweden)

    Hemant Kumar Nagar

    2016-01-01

    Full Text Available Objectives. The present study was aimed at investigating the wound healing effect of ethanolic extract of Cestrum nocturnum (L. leaves (EECN using excision and incision wound model. Methods. Wistar albino rats were divided into five groups each consisting of six animals; group I (left untreated considered as control, group II (ointment base treated considered as negative control, group III treated with 5% (w/w povidone iodine ointment (Intadine USP, which served as standard, group IV treated with EECN 2% (w/w ointment, and group V treated with EECN 5% (w/w ointment were considered as test groups. All the treatments were given once daily. The wound healing effect was assessed by percentage wound contraction, epithelialization period, and histoarchitecture studies in excision wound model while breaking strength and hydroxyproline content in the incision wound model. Result. Different concentration of EECN (2% and 5% w/w ointment promoted the wound healing activity significantly in both the models studied. The high rate of wound contraction (P<0.001, decrease in the period for epithelialization (P<0.01, high skin breaking strength (P<0.001, and elevated hydroxyproline content were observed in animal treated with EECN ointments when compared to the control and negative control group of animals. Histopathological studies of the EECN ointments treated groups also revealed the effectiveness in improved wound healing. Conclusions. Ethanolic extract of Cestrum nocturnum (EECN leaves possesses a concentration dependent wound healing effect.

  11. Efficacy of chlorhexidine gluconate ointment (Oronine H® for experimentally-induced comedones

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    Yamakoshi T

    2012-07-01

    Full Text Available Takako Yamakoshi,1 Teruhiko Makino,1 Kenji Matsunaga,1 Yoko Yoshihisa,1 Mati Ur Rehman,1 Taisuke Seki,2 Yoshito Hayashi,3 Tadamichi Shimizu11Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama-shi, Toyama; 2Seki Dermatological Clinic, Toyama-shi, Toyama; 3Otsuka Pharmaceutical Factory Inc, Naruto-shi, Tokushima, JapanBackground: Oronine H® ointment, which contains chlorhexidine gluconate as its active component, is a well known disinfectant, and has been widely used for treatment of acne in Japan. In this study, we investigated the inhibitory effect of this ointment on the formation of comedones induced by application of 50% oleic acid on the orifices of the external auditory canals of rabbits.Methods: The application sites were observed with a dermatoscope, and the area of the hair pores was measured using an Image analysis software program.Results: The chlorhexidine gluconate ointment inhibited comedone formation significantly more effectively than the liquid paraffin used as a control (P < 0.001. We also investigated the therapeutic effect of this ointment on comedones. After starting application of chlorhexidine gluconate ointment or liquid paraffin on the comedone area, the hair pore size was gradually decreased in the group treated with chlorhexidine gluconate ointment compared with the hair pore size at baseline.Conclusion: These results suggest that chlorhexidine gluconate ointment is effective for inhibiting comedone formation as well as for treating already formed comedones. Chlorhexidine gluconate ointment is a useful topical medicine for the treatment of early-stage acne and for preventing acne.Keywords: chlorhexidine gluconate ointment, comedones, dermatoscope, oleic acid

  12. The clinical evaluation of Pterocarpus santalinus Linn. Ointment on lower extremity wounds--a preliminary report.

    Science.gov (United States)

    Biswas, Tuhin Kanti; Maity, Lakshmi Narayan; Mukherjee, Biswapati

    2004-12-01

    Pterocarpus santalinus is described in the Ayurveda for its wide spectrum of medicinal properties including wound healing. Previously the authors reported animal studies that demonstrated that an ointment made from the bark of this tree was effective without any toxic effects. They used the same ointment in 6 cases of lower extremity wounds. Healing was observed in all wounds. The study was not controlled, the findings are presented here as case studies. Further studies are planned to develop a wound healing ointment from a locally available and inexpensive plant.

  13. Effect of ointment bases on topical and transdermal delivery of salicylic acid in rats: evaluation by skin microdialysis.

    Science.gov (United States)

    Murakami, T; Yoshioka, M; Okamoto, I; Yumoto, R; Higashi, Y; Okahara, K; Yata, N

    1998-01-01

    Microdialysis has been used to determine the concentration of salicylic acid in skin tissue and plasma periodically for 4 h to evaluate the effect of ointment bases on topical and transdermal delivery of salicylic acid. The ointment bases examined were solbase (water-soluble), poloid and white petrolatum (oleaginous), hydrophilic poloid (water in oil (w/o) type emulsion lacking water) and absorptive ointment (w/o-type emulsion containing water). The ointments (0.1 g) containing 25 micromol salicylic acid were applied for 2 h to the surface of rat skin (1 cm2) with (intact) or without the stratum corneum. For intact skin, the extent of topical delivery from different ointments, evaluated by the area under the concentration-time curve (AUC) of salicylic acid in the skin tissue (AUCskin), increased in the order solbase salicylic acid in plasma (AUCplasma, transdermal delivery) varied remarkably among the different bases, the greatest ratio being observed for absorptive ointment. When the ointments were applied to skin surface without stratum corneum, AUCskin for solbase was much higher (about 45 times that for intact skin), whereas only a small (two-fold) increase was observed for poloid and hydrophilic poloid and the increase was negligible for white petrolatum and absorptive ointment. For skin without the stratum corneum, the ratio AUCskin/AUCplasma for the different ointments was comparable, although the magnitudes of AUCskin and AUCplasma still varied substantially. The variance of AUC values arises as a result of the different rates of release of salicylic acid from the bases. These results indicate that: the topical and transdermal delivery of salicylic acid in intact skin varies substantially among different ointment bases, and the greatest topical delivery is observed for absorptive ointment; use of absorptive ointment increases the retention of salicylic acid in the stratum corneum; and the stratum corneum functions strongly as a penetration barrier for

  14. Effect of Plant Extracts Formulated in Different Ointment Bases on MDR Strains.

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    Pawar, Pallavi L; Nabar, Bela M

    2010-05-01

    Extracts of Aloe vera whole plant, Eucalyptus globulus leaves, Ficus infectoria bark, Ficus religiosa bark and Piper betel leaves were studied for antibacterial activity on resistant and sensitive strains, isolated from skin and soft tissue infections. A combination of hot alcoholic extracts of Ficus infectoria, Ficus religiosa and Piper betel were found to be more effective against all the isolates. The combined extract was formulated in different ointment bases such as polyethylene glycol, gelatin, sodium alginate, carbopol, cream base and honey. These were then evaluated to find a suitable base for preparation of an ointment. In vitro study of the release of antimicrobials and kill-time studies of the herbal ointments was carried out against multi-drug resistant isolate of Pseudomonas. The ointment showed bactericidal activity within 2 h against the resistant strain of Pseudomonas spp.

  15. Nitric oxide-releasing polymer incorporated ointment for cutaneous wound healing.

    Science.gov (United States)

    Kang, Youngnam; Kim, Jihoon; Lee, Yeong Mi; Im, Sooseok; Park, Hansoo; Kim, Won Jong

    2015-12-28

    This work demonstrates the development of nitric oxide-releasing ointment and its potential on efficient wound healing. Nitric oxide-releasing polymer was successfully synthesized, which is composed of biocompatible Pluronic F127, branched polyethylenimine and 1-substituted diazen-1-ium-1,2-diolates. The synthesized nitric oxide-releasing polymer was incorporated into the PEG-based ointment which not only facilitated nitric oxide release in a slow manner, but also served as a moisturizer to enhance the wound healing. As compared to control groups, the nitric oxide-releasing ointment showed the accelerated wound closure with enhanced re-epithelialization, collagen deposition, and blood vessel formation in vivo. Therefore, this nitric oxide-based ointment presents the promising potential for the efficient strategy to heal the cutaneous wound.

  16. Modulation of inflammation by Cicaderma ointment accelerates skin wound healing.

    Science.gov (United States)

    Morin, Christophe; Roumegous, Audrey; Carpentier, Gilles; Barbier-Chassefière, Véronique; Garrigue-Antar, Laure; Caredda, Stéphane; Courty, José

    2012-10-01

    Skin wound healing is a natural and intricate process that takes place after injury, involving different sequential phases such as hemostasis, inflammatory phase, proliferative phase, and remodeling that are associated with complex biochemical events. The interruption or failure of wound healing leads to chronic nonhealing wounds or fibrosis-associated diseases constituting a major health problem where, unfortunately, medicines are not very effective. The objective of this study was to evaluate the capacity of Cicaderma ointment (Boiron, Lyon, France) to accelerate ulcer closure without fibrosis and investigate wound healing dynamic processes. We used a necrotic ulcer model in mice induced by intradermal doxorubicin injection, and after 11 days, when the ulcer area was maximal, we applied Vaseline petroleum jelly or Cicaderma every 2 days. Topical application of Cicaderma allowed a rapid recovery of mature epidermal structure, a more compact and organized dermis and collagen bundles compared with the Vaseline group. Furthermore, the expression of numerous cytokines/molecules in the ulcer was increased 11 days after doxorubicin injection compared with healthy skin. Cicaderma rapidly reduced the level of proinflammatory cytokines, mainly tumor necrosis factor (TNF)-α and others of the TNF pathway, which can be correlated to a decrease of polymorphonuclear recruitment. It is noteworthy that the modulation of inflammation through TNF-α, macrophage inflammatory protein-1α, interleukin (IL)-12, IL-4, and macrophage-colony-stimulating factor was maintained 9 days after the first ointment application, facilitating the wound closure without affecting angiogenesis. These cytokines seem to be potential targets for therapeutic approaches in chronic wounds. Our results confirm the use of Cicaderma for accelerating skin wound healing and open new avenues for sequential treatments to improve healing.

  17. Development of a topical ointment of betamethasone dipropionate loaded nanostructured lipid carrier

    Directory of Open Access Journals (Sweden)

    Xin Kong

    2016-04-01

    Full Text Available The purpose of this study was to design an innovative topical ointment containing betamethasone dipropionate loaded nanostructured lipid carrier (BD-NLC for the treatment of atopic dermatitis (AD. BD-loaded NLC was produced with precirol ATO 5 and oleic oil (OA by melt emulsification method. Effects of surfactant concentration, amount of solid lipid and liquid lipid on skin retention and skin penetration were investigated by in vitro percutaneous permeation experiment. The optimized BD-NLC showed a homogeneous particle size of 169.1 nm (with PI = 0.195, negatively charged surface (−23.4 mV and high encapsulation efficiency (85%. Particle morphology assessed by TEM revealed a spherical shape. In vitro skin permeation study was carried out to investigate the percutaneous behaviors of W/O ointment with BD-NLC and Carbopol emulgel ointment with BD-NLC. W/O ointment with BD-NLC showed high skin retention (35.43 µg/g and low penetration (0.87 µg/ml. In vitro drug release studies were carried out to demonstrate the drug releasing properties of the two ointments. W/O ointment with BD-NLC showed an advantage for skin retention as it was better for drug release. The tissue distribution test suggested that BD distribution was skin > muscle > blood. Self-made topical ointment in mice showed no skin irritation. The animal experiments indicated that BD-loaded NLC ointment was effective and safe for topical use.

  18. Formulation and process factors influencing product quality and in vitro performance of ophthalmic ointments.

    Science.gov (United States)

    Xu, Xiaoming; Al-Ghabeish, Manar; Rahman, Ziyaur; Krishnaiah, Yellela S R; Yerlikaya, Firat; Yang, Yang; Manda, Prashanth; Hunt, Robert L; Khan, Mansoor A

    2015-09-30

    Owing to its unique anatomical and physiological functions, ocular surface presents special challenges for both design and performance evaluation of the ophthalmic ointment drug products formulated with a variety of bases. The current investigation was carried out to understand and identify the appropriate in vitro methods suitable for quality and performance evaluation of ophthalmic ointment, and to study the effect of formulation and process variables on its critical quality attributes (CQA). The evaluated critical formulation variables include API initial size, drug percentage, and mineral oil percentage while the critical process parameters include mixing rate, temperature, time and cooling rate. The investigated quality and performance attributes include drug assay, content uniformity, API particle size in ointment, rheological characteristics, in vitro drug release and in vitro transcorneal drug permeation. Using design of experiments (DoE) as well as a novel principle component analysis approach, five of the quality and performance attributes (API particle size, storage modulus of ointment, high shear viscosity of ointment, in vitro drug release constant and in vitro transcorneal drug permeation rate constant) were found to be highly influenced by the formulation, in particular the strength of API, and to a lesser degree by processing variables. Correlating the ocular physiology with the physicochemical characteristics of acyclovir ophthalmic ointment suggested that in vitro quality metrics could be a valuable predictor of its in vivo performance. Published by Elsevier B.V.

  19. DETERMINATION OF THE STABILITY AND SHELF LIFE OF OINTMENT WITH ZINC SALT OF HYALURONIC ACID AND THIOTRIAZOLINE

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    Bezrukaviy Y.A.

    2013-10-01

    Full Text Available Based on the results of physical-chemical andmicrobiological research investigated the stability andshelf life of ointment with zinc salt of hyaluronic acid andthiotriazoline. Ointment which stored in aluminum tubes,during all term of researches met all the indicators ofdrugs QC. Ointment which kept in jars from orange glassdid not meet the indicator "acidic number" in defining ofindicators per 24 months of storage. Was established shelflife of medication with zinc salt of hyaluronic acid andthiotriazoline - 2 years.

  20. Effects of various storage conditions and alterations of antioxidant contents on chromatic aberration of hydroquinone ointment.

    Science.gov (United States)

    Matsubayashi, Teruhisa; Sakaeda, Toshiyuki; Kita, Tomoko; Nakamura, Tsutomu; Kakumoto, Mikio; Funasaka, Yoko; Ichihashi, Masamitsu; Fujita, Takuya; Kamiyama, Fumio; Yamamoto, Akira; Nordlund, James J; Kaneko, Masafumi; Iida, Akira; Okumura, Katsuhiko

    2003-01-01

    Ointments of the skin depigmentation agent hydroquinone (HQ) have been prepared by extemporaneous nonsterile compounding in our hospital. The HQ ointments were highly effective in the treatment of various types of skin pigmentations; however, various problems have emerged including chromatic aberration of the ointments, a relatively large variability of efficacy, and mild side effects. Chromatic aberration is expected to induce non-compliance, and this may be the reason for the relatively large variability in efficacy. In this paper, the effects of various storage conditions on the chromatic aberration and HQ content of HQ ointments were evaluated, and it was suggested that the chromatic aberration was accelerated by exposure to high temperature, air and light, although these had no effect on the HQ content. In addition, various types of HQ ointments were prepared to find a formulation to minimize chromatic aberration, and it was found that the concentrations of antioxidants, Na(2)SO(3) and L(+)-ascorbic acid (AsA), seemed to be too high, and that the protective effect of AsA on chromatic aberration was mainly due to its acidifying effect.

  1. Synthesis of Anti-Acne Ointment of Ethanol Extract of White Plumeria Leaves (Plumeria Alba L.)

    Science.gov (United States)

    Ningsih, D. R.; Zusfahair; Kartika, D.; Lestari, I. T.

    2017-02-01

    Acne is a chronic inflammatory skin disease pilosebaceous follicle, where the oil- producing glands are clogged and contaminated by bacteria. Propionibacterium acne is one of the bacteria that contributes to the pathogenesis of acne. Acne treatment was done by reducing the population of bacteria using an antibacterial. One of the plants that have antibacterial activity is white plumeria. The ethanol extract of white plumeria leaves contains antibacterial secondary metabolites, which are alkaloids and saponins. The aim of this study is to formulate white plumeria leaves extract into the water leached ointment base. Characteristics of the ointment were determined by evaluating the stability of the ointment including organoleptic, adhesion test, dispersive power test, determination of pH, and the antibacterial activity test. The results showed that the ointment of ethanol extract of white plumeria leaves has some characteristics, semisolid form, white, has distinctive smell of ointment, homogeneous but not protective, has a pH of 4.57 - 6.10, dispersive power of 5.10 - 6.06 cm, the adhesiveness of 1.67 - 3 seconds, and optimum antibacterial activity at concentrations of 5 ppm providing inhibition zone of 24.00 mm.

  2. Accelerated in vivo wound healing evaluation of microbial glycolipid containing ointment as a transdermal substitute.

    Science.gov (United States)

    Gupta, Sonam; Raghuwanshi, Navdeep; Varshney, Ritu; Banat, I M; Srivastava, Amit Kumar; Pruthi, Parul A; Pruthi, Vikas

    2017-10-01

    A potent biosurfactant (BS) producing Bacillus licheniformis SV1 (NCBI GenBank Accession No. KX130852) was isolated from oil contaminated soil sample. Physicochemical investigations (TLC, HPLC, FTIR, GC-MS and NMR) revealed it to be glycolipid in nature. Fibroblast culture assay showed cytocompatibility and increased cell proliferation of 3T3/NIH fibroblast cells treated with this biosurfactant when checked using MTT assay and DAPI fluorescent staining. To evaluate the wound healing potential, BS ointment was formulated and checked for its spreadability and viscosity consistency. In vivo wound healing examination of full thickness skin excision wound rat model demonstrated the prompt re-epithelialization and fibroblast cell proliferation in the early phase while quicker collagen deposition in later phases of wound healing when BS ointment was used. These results validated the potential usage of BS ointment as a transdermal substitute for faster healing of impaired skin wound. Biochemical evaluation also substantiated the highest concentration of hydroxyproline (32.18±0.46, p<0.001) in the BS ointment treated animal tissue samples compared to the control. Hematoxylin-Eosin (H&E) and Masson's Trichrome staining validated the presence of increased amount of collagen fibers and blood vessels in the test animals treated with BS ointment. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  3. Pharmacological Investigation of the Wound Healing Activity of Cestrum nocturnum (L.) Ointment in Wistar Albino Rats.

    Science.gov (United States)

    Nagar, Hemant Kumar; Srivastava, Amit Kumar; Srivastava, Rajnish; Kurmi, Madan Lal; Chandel, Harinarayan Singh; Ranawat, Mahendra Singh

    2016-01-01

    Objectives. The present study was aimed at investigating the wound healing effect of ethanolic extract of Cestrum nocturnum (L.) leaves (EECN) using excision and incision wound model. Methods. Wistar albino rats were divided into five groups each consisting of six animals; group I (left untreated) considered as control, group II (ointment base treated) considered as negative control, group III treated with 5% (w/w) povidone iodine ointment (Intadine USP), which served as standard, group IV treated with EECN 2% (w/w) ointment, and group V treated with EECN 5% (w/w) ointment were considered as test groups. All the treatments were given once daily. The wound healing effect was assessed by percentage wound contraction, epithelialization period, and histoarchitecture studies in excision wound model while breaking strength and hydroxyproline content in the incision wound model. Result. Different concentration of EECN (2% and 5% w/w) ointment promoted the wound healing activity significantly in both the models studied. The high rate of wound contraction (P Cestrum nocturnum (EECN) leaves possesses a concentration dependent wound healing effect.

  4. [Refractometric determination of the fat base content in emulsion ointments (author's transl)].

    Science.gov (United States)

    Rudischer, S; Bauer, H J

    1981-01-01

    The Pharmacopoeia of the GDR provides no direct method for the determination of the fat base content in ointments. The indirect determination which is due to in calculating the difference between 100% and the percentages of all the other constituents is tedious and inexact. For this reason, it was tried to find a direct method which was to be reliable, rapid and easy. In principle, the refractometric method divised by Rudischer [2--5, 9] for the determination of fat in meat and meat products, which has been compulsory since 1965, is suitable for this purpose. Consequently, this method was adapted to the requirements of ointment analysis and subjected to modifications which resulted in the variant A for non-ionic ointments, and the variant B for ointments containing ionic fatty alcohol sulphates. The results obtained with the refractometric method from all kinds of ointments tested were in full agreement with the actual fat contents. Parallel determinations differed by 0.5% at the most.

  5. Investigation of cream and ointment on antimicrobial activity of Mangifera indica extract.

    Science.gov (United States)

    Awad El-Gied, Amgad A; Abdelkareem, Abdelkareem M; Hamedelniel, Elnazeer I

    2015-01-01

    Medicinal plants have curative properties due to the presence of various complex chemical substance of different composition, which are found as secondary plant metabolites in one or more parts of these plants. Mangifera indica Linn (MI L.) is a species of mango in the Anacardiaceae family. Phytoconstituents in the seed extracts may be responsible for the antimicrobial activity of the plant. The purpose of the study was to formulate and evaluate the antimicrobial herbal ointment and cream from extracts of the seeds of mango (MI L.) The formulated ointments containing oleaginous-based showed the best formulation compared to the emulsion water in oil type, the ointment and cream bases in different concentration 1%, 5% and 10%. The formulated ointment and cream of MI L. were subjected to evaluation of Uniformity of Weight, measurement of pH, viscosity, Spreadability, Acute skin irritation study, stability study and antimicrobial activity. Our study shows that MI has high potential as an antimicrobial agent when formulated as ointment and creams for topical use. Thus, the present study concludes that the formulated formulations of the MI are safe and efficient carriers, with potent antimicrobial activity.

  6. Investigation of cream and ointment on antimicrobial activity of Mangifera indica extract

    Directory of Open Access Journals (Sweden)

    Amgad A Awad El-Gied

    2015-01-01

    Full Text Available Medicinal plants have curative properties due to the presence of various complex chemical substance of different composition, which are found as secondary plant metabolites in one or more parts of these plants. Mangifera indica Linn (MI L. is a species of mango in the Anacardiaceae family. Phytoconstituents in the seed extracts may be responsible for the antimicrobial activity of the plant. The purpose of the study was to formulate and evaluate the antimicrobial herbal ointment and cream from extracts of the seeds of mango (MI L. The formulated ointments containing oleaginous-based showed the best formulation compared to the emulsion water in oil type, the ointment and cream bases in different concentration 1%, 5% and 10%. The formulated ointment and cream of MI L. were subjected to evaluation of Uniformity of Weight, measurement of pH, viscosity, Spreadability, Acute skin irritation study, stability study and antimicrobial activity. Our study shows that MI has high potential as an antimicrobial agent when formulated as ointment and creams for topical use. Thus, the present study concludes that the formulated formulations of the MI are safe and efficient carriers, with potent antimicrobial activity.

  7. Effects of clear topical ointment on transepidermal water loss in jaundiced pretermm infants receiving phototherapy.

    Science.gov (United States)

    Wananukul, S; Praisuwanna, P; Kesorncam, K

    2001-06-01

    Thirty jaundiced preterm infants, gestational age incubators were included. 1.5 ml of clear topical ointment was applied on the right side of the trunk and extremities while the left side was used as control. Data collection included transepidermal water loss (TEWL), ambient temperature and ambient humidity, before and at 30 minutes, 4-6 hours after application of the ointment during phototherapy. The measurements were executed both the right and left side in 3 positions; upper arm, back, lower leg. TEWL was reduced by 29 per cent (P value humidity were not significantly different (P value > 0.18). We concluded that application of clear topical ointment on the skin of jaundiced preterm infants receiving conventional phototherapy in incubators reduced TEWL significantly.

  8. Effects of nitroglycerin ointment on mastectomy flap necrosis in immediate breast reconstruction: a randomized controlled trial.

    Science.gov (United States)

    Gdalevitch, Perry; Van Laeken, Nancy; Bahng, Seokjae; Ho, Adelyn; Bovill, Esta; Lennox, Peter; Brasher, Penelope; Macadam, Sheina

    2015-06-01

    Mastectomy flap necrosis is a common complication of immediate breast reconstruction that impacts recovery time and reconstructive success. Nitroglycerin ointment is a topical vasodilator that has been shown to improve skin flap survival in an animal model. The objective of this study was to evaluate whether the application of nitroglycerin ointment to the breast skin after mastectomy and immediate reconstruction causes a decrease in the rate of mastectomy flap necrosis compared with placebo. This study was conducted as a randomized controlled trial and included patients aged 21 to 69 years undergoing mastectomy and immediate breast reconstruction at the University of British Columbia-affiliated hospitals (Vancouver, British Columbia, Canada). Patients with a medical history that precluded the administration of nitroglycerin were excluded from the study. The target sample size was 400 patients. Nitroglycerin ointment (45 mg) or a placebo was applied to the mastectomy skin at the time of surgical dressing. The trial was stopped at the first interim analysis after 165 patients had been randomized (85 to the treatment group and 80 to the placebo group). Mastectomy flap necrosis developed in 27 patients (33.8 percent) receiving placebo and in 13 patients (15.3 percent) receiving nitroglycerin ointment; the between-group difference was 18.5 percent (p = 0.006; 95 percent CI, 5.3 to 31.0 percent). Postoperative complications were similar in both groups [nitroglycerin, 22.4 percent (19 of 85); placebo, 28.8 percent (23 of 80)]. In patients undergoing mastectomy and immediate reconstruction, there was a marked reduction in mastectomy flap necrosis in patients who received nitroglycerin ointment. Nitroglycerin ointment application is a simple, safe, and effective way to help prevent mastectomy flap necrosis. Therapeutic, I.

  9. Momordica charantia ointment accelerates diabetic wound healing and enhances transforming growth factor-β expression.

    Science.gov (United States)

    Hussan, F; Teoh, S Lin; Muhamad, N; Mazlan, M; Latiff, A A

    2014-08-01

    Transforming growth factor-β (TGF-β) plays an important role in wound healing. Delayed wound healing is a consequence of diabetes, leading to high morbidity and poor quality of life. Momordica charantia (MC) fruit possesses anti-diabetic and wound healing properties. This study aimed to explore the changes in TGF-β expression in diabetic wounds treated with topical MC fruit extract. Fifty-six male Sprague-Dawley rats were divided into a normal control group and five diabetic groups of ten rats each. Intravenous streptozotocin (50mg/kg) was given to induce diabetes in the diabetic groups. Full thickness excision wounds were created on the thoracodorsal region of the animals, and these wounds were then treated with vehicle, MC powder, MC ointment and povidone ointment or ointment base for ten days. Wound healing was determined by the rate of wound closure, total protein content and TGF-β expression in the wounds, and histological observation. Diabetic groups showed delayed wound closure rates compared to the control group. The wound closure rate in the MC ointment group was significantly faster than that of the untreated diabetic group (p<0.05). The MC ointment group also showed intense TGF-β expression and a high level of total protein content. MC ointment has a promising potential for use as an alternative topical medication for diabetic wounds. This work has shown that it accelerates wound healing in diabetic rats, and it is suggested here that this occurs by enhancing TGF-β expression. Further work is recommended to explore this effect.

  10. Antimicrobial efficacy and wound-healing property of a topical ointment containing nitric-oxide-loaded zeolites.

    Science.gov (United States)

    Neidrauer, Michael; Ercan, Utku K; Bhattacharyya, Aparna; Samuels, Joshua; Sedlak, Jason; Trikha, Ritika; Barbee, Kenneth A; Weingarten, Michael S; Joshi, Suresh G

    2014-02-01

    Topical delivery of nitric oxide (NO) through a wound dressing has the potential to reduce wound infections and improve healing of acute and chronic wounds. This study characterized the antibacterial efficacy of an ointment containing NO-loaded, zinc-exchanged zeolite A that releases NO upon contact with water. The release rate of NO from the ointment was measured using a chemiluminescence detection system. Minimum bactericidal concentration assays were performed using five common wound pathogens, including Gram-negative bacteria (Escherichia coli and Acinetobacter baumannii), Gram-positive bacteria (Staphylococcus epidermidis and meticillin-resistant Staphylococcus aureus) and a fungus (Candida albicans). The time dependence of antimicrobial activity was characterized by performing log-reduction assays at four time points after 1-8 h ointment exposure. The cytotoxicity of the ointment after 24 h was assessed using cultured 3T3 fibroblast cells. Minimum microbicidal concentrations (MMCs) for bacterial organisms (5×10(7) c.f.u.) ranged from 50 to 100 mg ointment (ml media)(-1); the MMC for C. albicans (5×10(4) c.f.u.) was 50 mg ointment (ml media)(-1). Five to eight log reductions in bacterial viability and three log reductions in fungal viability were observed after 8 h exposure to NO-zeolite ointment compared with untreated organisms. Fibroblasts remained viable after 24 h exposure to the same concentration of NO-zeolite ointment as was used in antimicrobial tests. In parallel studies, full-thickness cutaneous wounds on Zucker obese rats healed faster than wounds treated with a control ointment. These data indicate that ointment containing NO-loaded zeolites could potentially be used as a broad-spectrum antimicrobial wound-healing dressing.

  11. [Blending powdered antineoplastic medicine in disposable ointment container].

    Science.gov (United States)

    Miyazaki, Yasunori; Uchino, Tomonobu; Kagawa, Yoshiyuki

    2014-01-01

    On dispensing powdered antineoplastic medicines, it is important to prevent cross-contamination and environmental exposure. Recently, we developed a method for blending powdered medicine in a disposable ointment container using a planetary centrifugal mixer. The disposable container prevents cross-contamination. In addition, environmental exposure associated with washing the apparatus does not arise because no blending blade is used. In this study, we aimed to confirm the uniformity of the mixture and weight loss of medicine in the blending procedure. We blended colored lactose powder with Leukerin(®) or Mablin(®) powders using the new method and the ordinary pestle and mortar method. Then, the blending state was monitored using image analysis. Blending variables, such as the blending ratio (1:9-9:1), container size (35-125 mL), and charging rate (20-50%) in the container were also investigated under the operational conditions of 500 rpm and 50 s. At a 20% charging rate in a 35 mL container, the blending precision of the mixtures was not influenced by the blending ratio, and was less than 6.08%, indicating homogeneity. With an increase in the charging rate, however, the blending precision decreased. The possible amount of both mixtures rose to about 17 g with a 20% charging rate in a 125 mL container. Furthermore, weight loss of medicines with this method was smaller than that with the pestle and mortar method, suggesting that this method is safer for pharmacists. In conclusion, we have established a precise and safe method for blending powdered medicines in pharmacies.

  12. Study on Vip protein expression in psoriatic epidermis with the topical treatment of capsaicin ointment

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Objective: To investigate the mechanism of capsaicin in treating active psoriasis vulgaris. Methods: VIP protein in active psoriatic lesions before and 30 days after the treatment of capsaicin ointment was detected by immunohistochemistry. Results:There was positive expression of VIP in all layers of psoriatic lesions epidermis (95.5 % ), but after the treatment of capsaicin ointment,there was nearly no expression of VIP protein in epidermis(22.2% ). Conclusion: Capsaicin inhibits proliferation and induces the differentiation of keratinocytes through down-regulating the expression of VIP in psoriatic epidermis.

  13. Chromatography of crotamiton and its application to the determination of active ingredients in ointments.

    Science.gov (United States)

    Izumoto, S; Machida, Y; Nishi, H; Nakamura, K; Nakai, H; Sato, T

    1997-06-01

    Crotamiton, which is a mixture of cis and trans isomers, was investigated by several separation techniques. One of the HPLC modes, in which crotamiton eluted as a single peak, was selected for the determination of five active ingredients (crotamiton, prednisolone, glycyrrhetinic acid, dibucaine and chlorhexidine hydrochloride) in an ointment. The simultaneous determination was performed using isocratic reversed-phase mode within 20 min by employing an octyl (C8) column and a mobile phase containing sodium dodecyl sulfate (SDS) and 2-propanol. The method was successfully applied to quality control and stability testing of the ointment.

  14. The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms

    Directory of Open Access Journals (Sweden)

    Shumei Jin

    2014-01-01

    Full Text Available Jing Wan Hong ointment contains 30 kinds of Chinese herbs, with functions of activating blood circulation to disperse blood stasis, clearing heat, eliminating dampness, and reducing swelling by detoxification. Therefore, Jing Wan Hong ointment may facilitate the healing of ulcers. The aim of this study was to evaluate the efficacy and mechanisms of Jing Wan Hong ointment for healing diabetic foot ulceration in Wistar rats induced by streptozotocin and sciatic nerve damage. The results showed that Jing Wan Hong ointment had a marked effect on foot ulcers in diabetic rats induced by initial nerve injury. These effects were manifested by reducing the foot ulcer size and Wagner grade after seven days of treatment. The diabetic rats with foot ulcers were almost healed after 21 days of treatment. Moreover, the mechanisms of this effect seem to be dependent on increased expression of PDGF mRNA, but there was no influence on the expression of TGF-β, VEGF, and FLT-1 mRNA.

  15. Drug-Induced Acute Pancreatitis Associated with 22-Oxacalcitriol Ointment for Treatment of Psoriasis

    Directory of Open Access Journals (Sweden)

    Munehiro Sato

    2009-05-01

    Full Text Available Dear Sir: Hypercalcemia is usually caused by malignancies or primary hyperparathyroidism, and only rarely by drugs [1]. Hypercalcemia can occasionally cause acute pancreatitis [2]. We herein report a case of severe acute pancreatitis induced by hypercalcemia which developed as a reaction to ointment containing 22- oxacalcitriol, a vitamin D3 analogue. A 72-year-old Japanese man with more than a 50-year history of psoriasis vulgaris developed generalized pustular psoriasis, which was refractory to combination therapy with corticosteroid and 22-oxacalcitriol ointments. He was referred to the Dermatology Dept. for further treatment. The patient’s clinical course is shown in Figure 1. Oral etretinate, an aromatic retinoid, was started, and the 22-oxacalcitriol ointment regimen was increased soon after admission. On hospital day 13, the skin lesions improved, but the patient developed abdominal discomfort and anorexia. As laboratory data showed an increased serum level of calcium (13.2 mg/dL; reference range: 8.7-10.0 mg/dL, the ointment was immediately discontinued.

  16. Clinical evaluation of an ointment with 10% metronidazole and 2% lidocaine in the treatment of alveolitis.

    Science.gov (United States)

    Silva, L J; Poi, W R; Panzarini, S R; Rodrigues, T S; Simonato, L E

    2006-01-01

    In this study, the authors evaluate the use of a 10% metronidazole and 2% lidocaine ointment, using a lanolin base and mint as flavoring, to treat alveolitis in humans. Twenty-five patients, with a diagnosis of alveolitis, were treated in the following way: locoregional anesthesia; surgical cleaning of the socket with alveolar curettes; saline solution irrigation with a 20 ml disposable syringe; and complete filling of the socket with the ointment. The analysis of the results showed that the painful symptoms were severe before and on the day of the treatment in 17 (68%) of the 25 patients treated. Post-treatment analysis presented 2 patients (18%) with severe painful symptoms after 24 h of the treatment and complete remission of painful symptoms after 48 h of the treatment with the ointment. Based on the results, it is possible to conclude that the 10% metronidazole and 2% lidocaine ointment, with mint flavoring and lanolin as a base, can be used to treat alveolitis.

  17. The efficacy of Jing Wan Hong ointment for nerve injury diabetic foot ulcer and its mechanisms.

    Science.gov (United States)

    Jin, Shumei; Zhang, Mixia; Gao, Yan; Zhang, Xuebin; Cui, Guangzhi; Zhang, Yanjun

    2014-01-01

    Jing Wan Hong ointment contains 30 kinds of Chinese herbs, with functions of activating blood circulation to disperse blood stasis, clearing heat, eliminating dampness, and reducing swelling by detoxification. Therefore, Jing Wan Hong ointment may facilitate the healing of ulcers. The aim of this study was to evaluate the efficacy and mechanisms of Jing Wan Hong ointment for healing diabetic foot ulceration in Wistar rats induced by streptozotocin and sciatic nerve damage. The results showed that Jing Wan Hong ointment had a marked effect on foot ulcers in diabetic rats induced by initial nerve injury. These effects were manifested by reducing the foot ulcer size and Wagner grade after seven days of treatment. The diabetic rats with foot ulcers were almost healed after 21 days of treatment. Moreover, the mechanisms of this effect seem to be dependent on increased expression of PDGF mRNA, but there was no influence on the expression of TGF-β, VEGF, and FLT-1 mRNA.

  18. Effect of Zicao ointment on second-degree burns in rats

    African Journals Online (AJOL)

    Conclusion: Zicao Ointment is effective for the treatment of second-degree burns in rats and may be .... Thermal burn injury is still a major cause of death ... Skin integrity is restored by ... from:http://ec.europa.eu/environment/chemicals/lab_ani.

  19. The effect of topical ointment on neonatal sepsis in preterm infants.

    Science.gov (United States)

    Erdemir, Aydin; Kahramaner, Zelal; Yuksel, Yelda; Cosar, Hese; Turkoglu, Ebru; Sutcuoglu, Sumer; Ozer, Esra Arun; Kose, Sukran

    2015-01-01

    To investigate the effects of topical ointment therapy on neonatal sepsis in premature infants. A total of 197 premature infants≤34 weeks gestation were randomized to receive topical ointment (Aquaphor Original Emollient) or routine skin care group. Skin cultures were obtained on 3th, 7th and 14th day and blood cultures were obtained if sepsis was suspected clinically. Data included the maternal and neonatal characteristics, factors affecting the risk of sepsis and neonatal outcomes of both groups were collected. There were no significant differences in terms of gestational age, birth weight, gender, mode of delivery, multiple pregnancy and receiving antenatal corticosteroids between the study and control group. No statistically significant difference was found in the prevalence of sepsis, in the positive skin culture rates at any follow-up and in terms of the neonatal morbidities including patent ductus arteriosus and necrotizing enterocolitis between the groups. Although the rate of death was higher in the topical ointment group, no statistically significant difference was found between the groups. Our data suggests that applying topical ointment during the first 2 postnatal weeks did not affect the risk of neonatal sepsis in preterm infants, although it changed the bacterial flora on the skin compare to the routine care group.

  20. Efficacy of mupirocin nasal ointment in eradicating Staphylococcus aureus nasal carriage in chronic haemodialysis patients

    NARCIS (Netherlands)

    D. L. Holton; L. E. Nicolle; D. Diley; K. Bernstein

    1991-01-01

    textabstractTopical 2% mupirocin ointment eradicated chronic Staphylococcus aureus nasal carriage immediately post-therapy in 17 (77%) of 22 haemodialysis patients. Mean time to recurrence was 3.8 weeks. Similar pre-therapy and post-therapy phage types occurred in 12 (71%) of 17 patients. Staphyloco

  1. 21 CFR 524.1600a - Nystatin, neomycin, thiostrepton, and triamcinolone acetonide ointment.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Nystatin, neomycin, thiostrepton, and... TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.1600a Nystatin, neomycin, thiostrepton, and triamcinolone... base ointment contains: 100,000 units of nystatin; neomycin sulfate equivalent to 2.5 milligrams...

  2. 21 CFR 524.1484i - Neomycin sulfate, hydrocortisone acetate, sterile ointment.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Neomycin sulfate, hydrocortisone acetate, sterile... NEW ANIMAL DRUGS § 524.1484i Neomycin sulfate, hydrocortisone acetate, sterile ointment. (a) Specifications. The drug contains 5 milligrams of neomycin sulfate, equivalent to 3.5 milligrams of neomycin...

  3. 21 CFR 524.1044d - Gentamicin sulfate, betamethasone valerate ointment.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Gentamicin sulfate, betamethasone valerate ointment. 524.1044d Section 524.1044d Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... preparation. Administration of recommended doses beyond 7 days may result in delayed wound healing. Animals...

  4. Kinetics of drug release from ointments: Role of transient-boundary layer.

    Science.gov (United States)

    Xu, Xiaoming; Al-Ghabeish, Manar; Krishnaiah, Yellela S R; Rahman, Ziyaur; Khan, Mansoor A

    2015-10-15

    In the current work, an in vitro release testing method suitable for ointment formulations was developed using acyclovir as a model drug. Release studies were carried out using enhancer cells on acyclovir ointments prepared with oleaginous, absorption, and water-soluble bases. Kinetics and mechanism of drug release was found to be highly dependent on the type of ointment bases. In oleaginous bases, drug release followed a unique logarithmic-time dependent profile; in both absorption and water-soluble bases, drug release exhibited linearity with respect to square root of time (Higuchi model) albeit differences in the overall release profile. To help understand the underlying cause of logarithmic-time dependency of drug release, a novel transient-boundary hypothesis was proposed, verified, and compared to Higuchi theory. Furthermore, impact of drug solubility (under various pH conditions) and temperature on drug release were assessed. Additionally, conditions under which deviations from logarithmic-time drug release kinetics occur were determined using in situ UV fiber-optics. Overall, the results suggest that for oleaginous ointments containing dispersed drug particles, kinetics and mechanism of drug release is controlled by expansion of transient boundary layer, and drug release increases linearly with respect to logarithmic time.

  5. HPLC-APCI-MS analysis of triacylglycerols (TAGs) in historical pharmaceutical ointments from the eighteenth century.

    Science.gov (United States)

    Saliu, Francesco; Modugno, Francesca; Orlandi, Marco; Colombini, Maria Perla

    2011-10-01

    The lipid fractions of residues from historical pharmaceutical ointments were analysed by reversed-phase liquid chromatography coupled with atmospheric pressure chemical ionization and mass spectrometer detection. The residues were contained in a series of historical apothecary jars, dating from the eighteenth century and conserved at the "Aboca Museum" in Sansepolcro (Arezzo, Italy) and at the pharmacy of the "Real Cartuja de Valldemossa" in Palma de Majorca (Spain). The analytical protocol was set up using a comparative study based on the evaluation of triacylglycerol (TAG) compositions in raw natural lipid materials and in laboratory-reproduced ointments. These ointments were prepared following pharmaceutical recipes reported in historical treatises and used as reference materials. The reference materials were also subjected to stress treatments in order to evaluate the modification occurring in the TAG profiles as an effect of ageing. TAGs were successfully detected in the reproduced formulations even in mixtures of up to ten ingredients and after harsh degradative treatments, and also in real historical samples. No particular interferences were detected from other non-lipid ingredients of the formulations. The TAG compositions detected in the historical ointments indicated a predominant use of olive oil and pig adipose material as lipid ingredients. The detection of a high level of tristearine and myristyl-palmitoyl-stearyl glycerol in two of the samples suggested the presence of a fatty material of a different origin (maybe a ruminant). On the basis of the positional isomer ratio, sn-PPO/sn-POP, it was possible to hypothesize an exclusive use of pig fat in one sample. We also evaluated the application of principal component analysis of TAG profiles as an approach for the multivariate statistical comparison of the reference and historical ointments.

  6. SUMMARY OF RESEARCHES ON THE TREATMENT OF PROTRUSION OF LUMBAR INTERVERTEBRAL DISC BY "SHE-BIE" OINTMENT-PARTITION MOXIBUSTION

    Institute of Scientific and Technical Information of China (English)

    蒋松鹤; 郁引飞; 叶天申

    2003-01-01

    In the present paper the authors sum up their research results about "She-Bie" (black-tail snake-ground beetle) Ointment-partition moxibustion for treatment of Iumbar intervertebral disc protrusion (LIDP). Animal ex-perirments showed that when used externally, "She-Bie" Ointment had striking anti-infllammation and pain-relief actionsbut had no irritant and no allergic effects to the skin. In the treatment of mild type of LIDP, "She-Bie" Ointment parti-tion moxibustion could work well in improving clinical symptoms; and in the treatment of moderate type of LIDP, itcould be used as a supplementary measure and raise the excellent and good rates of the therapeutic effect further. Forthis reason, "She-Bie" Ointment partition moxibustion deserves being Popularized in clinical treatment of LIDP.

  7. Study on vasoactive intestinal polypeptide receptor 1 gene translation in psoriatic epidermis with the topical treatment of capsaicin ointment

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Objective To investigate the mechanism of capsaicin in treating active psoriasis vulgaris.Methods A total of 42 patients with active psoriasis vulgaris diagnosed by histology and clinical features were given either placebo or 0.025% capsaicin ointment four times daily for 30 days randomly by double-blind method.Vasoactive intestinal polypeptide receptor 1(VIPR1)gene translation in active psoriatic lesions before and after treatment with capsaicin ointment was detected by in situ hybridization.Results There ...

  8. The influence of the viscosity of the ointment vehicles magisterial topical preparations, on the speed transfer of biologically active substances

    Directory of Open Access Journals (Sweden)

    Glogowski Adrian

    2015-09-01

    Full Text Available The aim of this study was to analyze the morphological parameters (viscosity, viscous elasticity and the rate of volatile component loss of salicylic and boric acid-containing magisterial formulae (ointments. Moreover, the effects of these parameters on the diffusion rate of a therapeutic agent (salicylic acid to an in vitro external compartment were analyzed. Finally, the applicatory properties of the ointments prepared by way of a conventional technique (in a mortar and with the aid of an unguator, were compared. The rheological parameters of the analyzed ointments suggest that the preparations made with an aid of an unguator, irrespective of the physicochemical characteristics of their vehicles, are characterized by higher values of diffusion coefficient (D. In addition, conventionally-prepared formulae containing salicylic were shown to be characterized by better viscous elasticity. Surprisingly, irrespective of the preparation technique, the ointments based on an absorptive vehicle (containing lanolin were characterized by similar viscous elasticity. The rate of volatile (water component loss from ointments containing a 3% solution of boric acid suggests that such formulae lose no more than 2.3% of their mass when exposed at 37℃. Therefore, the viscosity of such ointments applied onto a patient’s skin should remain relatively stable.

  9. Superiority of terahertz over infrared transmission through bandages and burn wound ointments

    Science.gov (United States)

    Suen, Jonathan Y.; Padilla, Willie J.

    2016-06-01

    Terahertz electromagnetic waves have long been proposed to be ideal for spectroscopy and imaging through non-polar dielectric materials that contain no water. Terahertz radiation may thus be useful for monitoring burn and wound injury recovery, as common care treatments involve application of both a clinical dressing and topical ointment. Here, we investigate the optical properties of typical care treatments in the millimeter wave (150-300 GHz), terahertz (0.3-3 THz), and infrared (14.5-0.67 μm) ranges of the electromagnetic spectrum. We find that THz radiation realizes low absorption coefficients and high levels of transmission compared to infrared wavelengths, which were strongly attenuated. Terahertz imaging can enable safe, non-ionizing, noninvasive monitoring of the healing process directly through clinical dressings and recovery ointments, minimizing the frequency of dressing changes and thus increasing the rate of the healing process.

  10. Superiority of terahertz over infrared transmission through bandages and burn wound ointments

    Energy Technology Data Exchange (ETDEWEB)

    Suen, Jonathan Y., E-mail: j.suen@duke.edu; Padilla, Willie J. [Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina 27708 (United States)

    2016-06-06

    Terahertz electromagnetic waves have long been proposed to be ideal for spectroscopy and imaging through non-polar dielectric materials that contain no water. Terahertz radiation may thus be useful for monitoring burn and wound injury recovery, as common care treatments involve application of both a clinical dressing and topical ointment. Here, we investigate the optical properties of typical care treatments in the millimeter wave (150–300 GHz), terahertz (0.3–3 THz), and infrared (14.5–0.67 μm) ranges of the electromagnetic spectrum. We find that THz radiation realizes low absorption coefficients and high levels of transmission compared to infrared wavelengths, which were strongly attenuated. Terahertz imaging can enable safe, non-ionizing, noninvasive monitoring of the healing process directly through clinical dressings and recovery ointments, minimizing the frequency of dressing changes and thus increasing the rate of the healing process.

  11. Evaluation of toxicological properties and photodynamic activity of Photolon ointment: an experimental study

    Science.gov (United States)

    Shliakhtsin, Siarhei V.; Trukhachova, Tatsiana V.; Istomin, Yuriy P.; Dunetz, Ludmila N.; Kuvshinov, Andrey V.; Naumovich, Semen A.

    2009-06-01

    The purpose of the present study was to evaluate toxicological properties and photodynamic activity of a new ready form of the photosensitizer Photolon (Fotolon) - an ointment for topical use. The data obtained show the use of topicaly applied photosensitizer provides sufficient penetration and accumulation of the active compound in tumor tissue as well as in affected periodontal tissues for the effective PDT. There are several advantages of PDT with topical application of the photosensitizer such as absence of systemic toxic and photosensitive reactions, relatively low cost of the treatment and etc. We have shown that PDT of affected periodontal tissues with local application of Photolon/Fotolon ointment provides an ability of local destruction of microbial cell, located as on the gum surface as in the spatium intercellulare what is extremely important for successful treatment of acute and chronic periodontitis.

  12. Aggressive treatment of acute anal fissure with 0.5%nifedipine ointment prevents evolution to chronicity

    Institute of Scientific and Technical Information of China (English)

    Panagiotis Katsinelos; Jannis Kountouras; George Paroutoglou; Athanasios Beltsis; Grigoris Chatzimavroudis; Christos Zavos; Taxiarchis Katsinelos; Basilis Papaziogas

    2006-01-01

    AIM: To investigate the efficacy of topical application of 0.5% nifedipine ointment in healing acute anal fissue and preventing its progress to chronicity.METHODS: Thirty-one patients (10 males, 21 females)with acute anal fissure from September 1999 to January 2005 were treated topically with 0.5% nifedipine ointment (t.i.d.) for 8 wk. The patients were encouraged to follow a high-fiber diet and assessed at 2, 4 and 8wk post-treatment. The healing of fissure and any side effects were recorded. The patients were subsequently followed up in the outpatient clinic for one year and contacted by phone every three months thereafter,while they were encouraged to come back if symptoms recurred.RESULTS: Twenty-seven of the 31 patients completed the 8-wk treatment course, of them 23 (85.2%)achieved a complete remission indicated by resolution of symptoms and healing of fissure. Of the remaining four unhealed patients (14.8%), 2 opted to undergo lateral sphincterotomy and the other 2 to continue therapy for four additional weeks, resulting in healing of fissure. All the 25 patients with complete remission had a mean follow-up of 22.9 ± 14 (range 6-52) mo. Recurrence of symptoms occurred in four of these 25 patients (16%)who were successfully treated with an additional 4-wk course of 0.5% nifedipine ointment. Two of the 27 (7.4%)patients who completed the 8-wk treatment presented with moderate headache as a side effect of nifedipine.CONCLUSION: Topical 0.5% nifedipine ointment, used as an agent in chemical sphincterotomy, appears to offer a significant healing rate for acute anal fissure and might prevent its evolution to chronicity.

  13. Comparative Efficacy of Topical Pertmehrin, Crotamiton and Sulfur Oint-ment in Treatment of Scabies

    OpenAIRE

    Celestyna Mila-Kierzenkowska; Alina Woźniak; Ewa Krzyżyńska-Malinowska; Lucyna Kałużna; Roland Wesołowski; Wojciech Poćwiardowski; Marcin Owcarz

    2017-01-01

    Background:  Scabies is an ectoparasitic infection, which occurs because of direct skin-to skin contact. The ideal treatment modality is still unclear and further research on this topic is warranted. The aim of the study was to com­pare the efficacy and safety of the topical scabicides: permethrin, crotamiton and sulfur ointment.Methods: Fifty four patients with diagnosed scabies were randomly divided into three treatment groups. The first group received 5% permethrin cream twice with one wee...

  14. Proximate Results in the Therapy of Skin Cancer with Omaine Ointment USSR.

    Science.gov (United States)

    1960-07-28

    ta^ separated, the ulcer cleared up and its £^6^ became soft Such a course was particularly observable in Parents having the exophytic form of...plications of the ointment were required «»^1 *£*tiz^zlfhe manifestations of the tumor disappeared and the bottom of the ulcer became covered with...complaints of a nonhealing ulcer of the skin of the upper lip on the right side. The ulcer first appeared In 1937. At first, th? patient contacted

  15. [Effects of tobramycin dexamethasone eye ointment for blepharitis: multi-center clinical trial].

    Science.gov (United States)

    Yan, Xiao-ming; Sun, Xu-guang; Xie, Han-ping; Hong, Jing; Wang, Zhi-cong

    2013-01-01

    To realize the effectiveness and security of Tobramycin and Dexamethasone Eye Ointment for blepharitis treatment. Design Case control studies. Participants 148 patients be diagnosed as blepharitis including 81 cases as research group and 67 cases as control group. Multi-center randomized controlled clinical trial. The patients met the inclusion criteria from First Hospital Peking University, Beijing Tongren Hospital, Southwest Hospital, Ophthalmology Center Zhongshan University and Third Hospital Peking University were divided into two groups in Aug. to Dec. 2011. Tobramycin dexamethasone eye ointment was applied to eye lid in research group while patients in control group used tobramycin eye ointment. All patients were informed to apply warm compress to the lids, mechanically washing to the eyelids and artificial tears. At the beginning, the 7(th) day, the 14(th) day and the 28(th) day of treatment, observation of symptom, sign and side effect were recorded. Before treatment the difference of the symptom scores of burning sensation, tears, photophobia and itch of two groups has no statistically significant (t = 1.87, 0.43, -0.64, 0.93, P > 0.05), but the symptom scores have a statistically significant decrease (t = 1.99 - 6.90, P effect: the number of patients with elevated intraocular pressure of research and control group is 3 and 1 respectively and the ratio is 3.7% and 1.5%. The tobramycin dexamethasone eye ointment can improve signs and symptoms of blepharitis patients. Some patients have to face with the risk of elevated intraocular pressure and it's necessary to monitor the intraocular pressure.

  16. Development of an ointment for burns based in dry extract of the seaweed Fucus spiralis

    Directory of Open Access Journals (Sweden)

    Clélia Neves Afonso

    2014-06-01

    Full Text Available The Fucus spiralis is a brown seaweed found on the Portuguese coast used as wound healing in traditional medicine were their antioxidant, immunostimulant, anticoagulant, antibacterial properties and also remineralizing, smoothing, moisturizing capacities and anti-tumor action were studied with proved results. These seaweed are one of the several described in the European Pharmacopoeia, making F.spiralis a seaweed with great potential for the development of new drugs and/or pharmaceuticals. The objective of this project was to formulate an ointment with F. spiralis dry extracts using vaseline as a base for the treatment of burns. Fucus spiralis was collected on the coast of Peniche (west coast of Portugal, washed, sorted, lyophilized and crushed for the dry extract preparation. The ash (g/g and iodine (% content in F. spiralis were determined. The ointment was prepared and homogenized with three concentrations of dry extract (1%, 2% and 5% and were analyzed over time in parallel with the observation of the physical, chemical, organoleptic and rheological characteristics. The results showed that the F. spiralis presented a iodine content of 0,0076%, a low concentration in comparison with the Farmacopeia europea directives. The ointment prepared is a non-Newtonian fluid, and the absorption spectrum in ultraviolet light (UV detected that it behaves as UVB and UVC blocker, despite of not having the same effect on UVA radiation. With these results and the many properties of Fucus spiralis we conclude that the ointment with dry extract of F. spiralis with the three concentrations of dry extract established is likely to have a great potential in the area of pharmaceutical and medicine, especially for burns application or other skins disorders.

  17. In vivo wound healing activity of a herbal ointment in rat

    Directory of Open Access Journals (Sweden)

    M. Karami

    2016-06-01

    Full Text Available Background and objectives: The wounds are still the health tribulations at the present time. In the present research the effect of a new herbal ointment (Oppyheal in treatment of rat’s wound has been investigated. The effectiveness of the ointment was compared with the Fibrinolysin/DNAse. Methods: Fifty four male Wistar rats were used. The wound was created on the back cervical skin of the animals under anesthesia in three different sizes. The animals in each size group were randomly divided into three groups. The control group did not receive the ointments. The reference group was given the Fibrinolysin/DNAse and the third group was treated with the Oppyheal. The products were topically used once per day until the wounds of one group were completely healed. The size of the wound area was measured in days 0-20 by a standard reference ruler. The reduction in size of the wound was calculated and analyzed. The recovered skin of all animals were examined histologically, p

  18. Fabrication of anti-vitiligo ointment containing Psoralea corylifolia: in vitro and in vivo characterization

    Science.gov (United States)

    Hussain, Irshad; Hussain, Nisar; Manan, Abdul; Rashid, Abdur; Khan, Barkat; Bakhsh, Sattar

    2016-01-01

    Background Vitiligo is a repugnant and odious dermatological malady of the time. It has an detrimental impact on the pigmentation of the human skin as a result of the destruction of cutaneous melanocytes. It affects 1%–2% of the population worldwide. Different therapeutic regimens have been deployed to treat vitiligo, but none of them could stand alone to be stated as a perfect cure. Recently, a change has been observed through novel experimental-designed optimization leading to the development of an anti-vitiligo ointment containing Psoralea corylifolia (PC) seed powder. Aim The aim of this study was to explore the clinical outcomes of ointment containing powdered seeds of PC. Materials and methods Guided by the protocol Response Surface Methodology, 13 formulations of concentration variance of permeation enhancers were prepared. The formulation fulfilling the required criteria (pH; temperature stability tests at 8°C±0.1°C, 25°C±0.1°C and 40°C±0.1°C; and the physical properties such as color, bleeding and rheology) was selected for clinical trials. Fourier transform infrared spectroscopy studies of seed powder of PC and selected formulation of the seed powder were performed. After obtaining informed consents and with prior approval of university and hospital ethical review boards, 20 patients (age range 25–65 years) were included in the present study. Formulations were applied on the affected body parts of patients, and some affected portion of the same patient was taken as control (self-control study design). The pigmentation of white spots of vitiligo was photographically evaluated before, during and after 12 weeks of treatment. Analysis of the measured values was performed using GraphPad Prism version 5 statistical software. A paired sample t-test was performed to observe variation between repigmented patches and white patches of self-control. Results Hydrophilic ointment (10% w/w) prepared with seed powder of PC was fabricated. The ointment was

  19. Treatment of shoulder ulcers in sows – rubber mats and zinc ointment compared to chlortetracycline spray

    Science.gov (United States)

    2013-01-01

    Background Shoulder ulcers can have a significant impact on the welfare of sows. In Denmark, rubber mats are used for treatment of shoulder ulcers. The objective of the study was to compare a treatment consisting of a combination of rubber mats and zinc ointment with the effect of local antibiotic spray (chlortetracycline) on shoulder ulcers. Methods A total of 304 sows with shoulder ulcers were observed shortly after farrowing (day 1) and on days 14 and 21 after the first observation. The sows were paired according to the grade of the shoulder ulcer using the official Danish scoring system. From each pair of sows, one sow was allocated to mat group (M) and the other to an antibiotic group (A) in a random way. In the M group, rubber mats were placed on the floor, and the ulcers were treated with zinc ointment once a day. In the A group, sows were treated with antibiotic spray daily. The size of the shoulder ulcer was measured manually on a continuous scale on days 1, 14 and 21. The data were analysed by use of two multivariable models where the response was the area of the shoulder ulcer on day 14 and day 21, respectively. Explanatory variables were treatment, herd, parity, body condition and size of ulcer on day 1. If a sow had an ulcer on both shoulders, the shoulder with the largest ulcer was selected. Results The treatment consisting of mats and zinc ointment had a statistical significant effect on the size of the shoulder ulcer on day 14 and day 21 compared to daily treatment with antibiotic spray. For lean sows that were kept on rubber mats and zinc ointment, the average shoulder ulcer was significantly smaller on day 14 (3.8 cm2 versus 9.5 cm2 when antibiotic spray was used) and day 21 (3.4 cm2 versus 6.6 cm2) compared to lean sows that were only treated with antibiotic spray. For fat sows this was also the case when using the lesion on day 21 as the response (2.0 cm2 versus 5.7 cm2) but not on day 14. Moreover, the size of the lesion on day 1 was

  20. 什么是湿润烧伤膏%What is Moist Exposed Burn Ointment

    Institute of Scientific and Technical Information of China (English)

    舒叶

    2012-01-01

      目的通过美宝湿润烧伤膏的基本组成部分及国内外基础研究结果对湿润烧伤膏的几大作用机理做详细解读。方法对国内外近20年已发表的关于美宝湿润烧伤膏机理研究的论文做回顾性总结,对美宝湿润烧伤膏在烧伤创面的作用:建立和保持生理性湿润环境、止痛作用、无损伤液化排出创面坏死组织、抗炎作用、防瘢作用、抑菌作用、皮肤再生(角蛋白19型干细胞激活及烧伤创面皮肤生理性愈合)进行系统论证及数据分析。结果美宝湿润烧伤膏在烧伤创面上能切实有效地发挥上述作用。结论美宝湿润烧伤膏作为烧伤再生医学与疗法的配套药膏在创面治疗及全身系统治疗中发挥了重要作用,是当今烧伤治疗中的黄金疗法。%  Objective To illustrate the properties of Moist Exposed Burn Ointment through the analysis of its com-positions and the presentation of basic studies at home and abroad on Moist Exposed Burn Ointment. Methods A retro-spective summary was given on the published papers in domestic and oversea journals in the recent 20 years regarding mech-anisms of Moist Exposed Burn Ointment. The systemic demonstration and data support were provided to testify the following properties of Moist Exposed Burn Ointment: creation and maintenance of physiologically moist environment, analgesic effect, liquefaction and discharge of necrotic tissues without secondary damage to potential viable tissues, anti-inflammatory effect, anti-scarring effect, bacteriostatic effect, skin regeneration (activation of keratin-19 stem cell and physiological heal-ing of burn wound). Results Moist Exposed Burn Ointment exerts the above effects in a solid and effective way. Conclu-sion Moist Exposed Burn Ointment, as the topical agent attached with Burns Regenerative Medicine and Therapy has the significant effects in wound care and systemic care of burn patients. Moist Exposed Burn Ointment

  1. Once-daily application of calcipotriene 0.005%-betamethasone dipropionate 0.064% ointment for repigmentation of facial vitiligo.

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    Newman, Marissa D; Silverberg, Nanette B

    2011-11-01

    Vitiligo vulgaris is an autoimmune pigmentary disorder with no universally efficacious therapeutic options. Separate applications of calcipotriene ointment 0.005% and topical corticosteroid ointments have been successful in the repigmentation of vitiligo. We sought to examine the efficacy of a combination calcipotriene 0.005%-betamethasone dipropionate 0.064% ointment in the repigmentation of vitiligo. An institutional review board-approved retrospective chart review was conducted in 13 pediatric and adult patients with vitiligo treated with calcipotriene 0.005%-betamethasone dipropionate 0.064% ointment once daily for at least 2 months. Two of 3 children had 76% to 100% repigmentation of facial vitiligo with once-daily usage after 2 months. Of the 10 adults (aged 28-55 years), 1 had 100% facial repigmentation in 3 months, 1 had 76% to 99% facial repigmentation in 5 to 9 months, and 2 had 26% to 50% repigmentation in 3 months. Twelve patients developed some facial repigmentation. No patients experienced atrophy, telangiectases, or lesion enlargement during treatment. Combination calcipotriene 0.005%-betamethasone dipropionate 0.064% ointment shows promise as a once-daily vitiligo therapy. Adult and pediatric facial vitiligo patients may see repigmentation as early as 2 months after initiation of therapy. Children may experience a better response, but larger studies are needed.

  2. An open label prospective randomized trial to compare the efficacy of coal tar-salicylic acid ointment versus calcipotriol/betamethasone dipropionate ointment in the treatment of limited chronic plaque psoriasis

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    Sujay Khandpur

    2014-01-01

    Full Text Available Background: Chronic plaque psoriasis is a common papulosquamous skin disorder, for which a number of topical agents are being used including coal tar, topical steroids and more recently topical calcipotriol/betamethasone dipropionate. There is no study comparing purified coal tar preparation with calcipotriol/betamethasone dipropionate ointment in limited chronic plaque psoriasis. Aims and Objectives: A prospective randomized open label controlled trial to compare the efficacy and safety of topical application of coal tar-salicylic acid ointment with calcipotriol/betamethasone dipropionate ointment applied once at night for 12 weeks for the treatment of limited chronic plaque psoriasis. Materials and Methods: A total of 62 patients of limited chronic plaque psoriasis (body surface area <10% were randomized into two treatment groups: Group A received topical application of 6% coal tar with 3% salicylic acid ointment and Group B received calcipotriol/betamethasone dipropionate, once at night for 12 weeks. Results were assessed based on psoriasis area severity index (PASI scores and patient global assessment (PGA at each visit. Results: Mean PASI was significantly lower at week 2 (P = 0.01 and week 4 follow-up (P = 0.05 and the mean reduction in PASI was significantly higher at week 2 (P = 0.02 with calcipotriol/betamethasone than coal tar-salicylic acid, but this difference was not sustained at subsequent follow-up visits. Similarly, PGA scores at weeks 2 and 4 were significantly lower with calcipotriol/betamethasone dipropionate ointment (P = 0.003 and P = 0.007 respectively. There was no significant difference in any parameter during subsequent follow-up visits or at the end of the treatment phase (12 weeks. Conclusion: Topical nightly application of calcipotriol/betamethasone dipropionate ointment leads to an initial, more rapid reduction in disease severity, but the overall outcome parameters are comparable in the two treatment groups.

  3. Effect of Robusta coffee beans ointment on full thickness wound healing

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    Yorinta Putri Kenisa

    2012-03-01

    Full Text Available Background: Traumatic lesions, whether chemical, physical, or thermal in nature, are among the most common lesion in the mouth. Wound healing is essential for the maintenance of normal structure, function, and survival of organisms. Experiments of Robusta coffee powder on rat-induced alloxan incision wound, clinically demonstrated similar healing rate with the povidone iodine 10%. No studies that look directly the effect of coffee extract in ointment form when viewed in terms of histopathology. Robusta coffee bean (Coffea canephora consists of chlorogenic acid (CGA and caffeic acid which are belived to act as antioxidant and take part in wound healing process. Purpose: The aim of this study was to identify the enhancement of healing process of full-thickness skin wound after Robusta coffee beans extract ointment application. Methods: Sample consisted of 20 Cavia cabaya treated with full-thickness with wounds and was given Robusta coffee beans extract ointment concentration range of 22.5%, 45%, and 90% except the control group which was given ointment base material. Animals were then harvested on the fourth day and made for histopathological preparations. Data were calculated and compared by one-way ANOVA test and LSD test. Results: The study showed that Robusta coffee bean extract ointment can increase the number of lymphocytes, plasma cells, macrophages, fibroblasts, and blood vessels by the presence of chlorogenic acid (CGA and Caffeic acid. Conclusion: In conclusion Robusta coffee bean extract ointment enhance the healing process of fullthickness skin wound of Cavia cabaya.Latar belakang: Lesi traumatik, baik akibat rangsang kimia, fisik, atau termal, merupakan lesi yang paling umum terjadi di dalam rongga mulut. Penyembuhan luka yang terjadi ini penting untuk pemeliharaan struktur normal, fungsi, dan kelangsungan hidup organisme. Percobaan pemberian bubuk kopi Robusta terhadap luka sayatan pada tikus yang diinduksi aloksan, secara klinis

  4. Amish burn ointment and burdock leaf dressings: assessments of antimicrobial and cytotoxic activities.

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    Rieman, Mary T; Neely, Alice N; Boyce, Steven T; Kossenjans, William J; Durkee, Paula J; Zembrodt, Jacquelyn M; Puthoff, Barbara K; Kagan, Richard J

    2014-01-01

    Amish burn wound ointment (ABO) contains honey, lanolin, oils, glycerin, bees wax, and other natural additives. Although there are many anecdotal reports that this ointment covered with a burdock leaf (BL) dressing promotes burn wound healing, little scientific testing of this treatment has occurred. The goal of this study was to evaluate in vitro some of the components of this treatment modality for antimicrobial and cytotoxic activities. The ABO was tested for sterility using standard microbiological techniques. Because of the semisolid, lipid-based nature of the salve, the at-use product could not be tested in bioassays. Samples of BL and the dry ingredients (DI) used in the ointment were provided by the Amish vendor. Aqueous extracts of the DI and of the BL were prepared and freeze dried. The freeze-dried extracts were reconstituted, filtered, and tested separately on keratinocyte and fibroblast cell cultures for cytotoxicity (growth inhibition assay) and against a panel of susceptible and resistant microbes for antimicrobial activity (Nathan's agar-well diffusion assay) in a series of concentrations (% wt/vol). Neither DI nor BL extracts demonstrated antimicrobial activity against any of organisms tested. The DI extract inhibited growth of both keratinocytes and fibroblasts at the 0.1% concentration. The 0.1 and 0.03% concentrations of the BL extract were cytotoxic to both keratinocytes and fibroblasts. Although tests for microbial growth from the at-use preparation of the ABO were negative, extracts of the DI and BL did not demonstrate any antimicrobial activity. Additionally, both extracts inhibited the growth of skin cells in vitro at higher concentrations. These results suggest caution in the use of ABO and BL dressings if there is more than a minimal risk of complications from the burn injury.

  5. Assessment of the physical properties and stability of mixtures of tetracycline hydrochloride ointment and acyclovir cream.

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    Inoue, Yutaka; Furuya, Kayoko; Maeda, Rikimaru; Murata, Isamu; Kanamoto, Ikuo

    2013-04-15

    In dermatology, ointments are often mixed as part of drug therapy, but mixing often leads to incompatibility. Three combinations of tetracycline ointment (TC-o) and acyclovir cream (ACV-cr) were prepared at a TC-o:ACV-cr ratio of 1:1 using a brand-name ACV-cr and two generic ACV-cr (samples TC-o+ACV-A, TC-o+ACV-B, and TC-o+ACV-C). Microscopic examination revealed separation in TC-o+ACV-C. Viscosity and elasticity measurement indicated that the storage modulus (G') and loss modulus (G″) of each of the TC-o+ACV-cr mixtures behaved similarly to those of an ACV-cr and the loss tangent (tanδ) behaved similarly to that of a TC ointment. In addition, differences in the storage modulus (G') and loss modulus (G″) of the TC-o+ACV-cr mixtures were noted. To assess stability, each TC-o+ACV-cr mixture was stored away from direct sunlight at 25 °C and an RH of 84% and at 4 °C (in a refrigerator). HPLC revealed that the ACV content in each TC-o+ACV-cr mixture remained at 95-105% for up to 14 days under both sets of storage conditions. A decline in TC content in each TC-o+ACV-cr mixture was not noted with storage at 4 °C but was noted over time with storage at 25 °C and an RH of 84%. In addition, significant differences in the percent decline in TC content in each TC-o+ACV-cr mixture occurred with storage at 25 °C and an RH of 84%. Thus, differences in physical properties and stability may occur when combining brand-name and generic drugs, and temperature and humidity may be the cause of the TC-o's incompatibility.

  6. Efficacy of nitroglycerine ointment in the treatment of pediatric anal fissure.

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    Joda, Ali E; Al-Mayoof, Ali F

    2017-04-08

    Anal fissure is the most common anal disease in children. In the past few decades, the understanding of its pathophysiology has led to a progressive reduction in invasive procedures in favor of conservative treatment based on stool softeners and the relaxation of the anal sphincter. This randomized controlled study assessed the safety and efficacy of nitroglycerine (NTG) ointment in the treatment of pediatric anal fissure, which had not yet been proved. An unequal randomized controlled study included 105 pediatric patients with anal fissure who had presented to the private and outpatient clinics of the Central Teaching Hospital of Pediatrics during the period from February 2015 to May 2016. The control group consisted of 70 patients. Both groups were treated with classical conservative therapy of sitz bath, stool softener, and local anesthetic. In the second group, chemical sphincterotomy with 0.2% NTG ointment was used in 35 patients, and was applied at the anal canal twice daily for 8weeks. The primary outcomes of symptomatic improvement and healed fissure, as well as side effects, were analyzed. The average age of patients was 2years (range, 4months to 5years). Patients in the NTG group had 77% symptomatic relief and 60% healed fissure compared to the control group, which had 54% and 32.8% respectively. All were statistically significant. No serious adverse effects were noticed during the treatment period. The use of 0.2% NTG ointment is an effective therapy for anal fissure in children in terms of good healing rate and rapid symptom relief, but it has the drawback of a long treatment period, making patient compliance more difficult, in addition to the problems of tolerance and recurrence. Prospective randomized controlled study (treatment study). Type 2. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. The efficacy of moisture retentive ointment in the mangement of cutaneous wounds and ulcers: A multicenter clinical trial

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    Atiyeh B

    2003-01-01

    Full Text Available Local management of chronic wounds and ulcers remains one of the most costly unsolved problems in health care today. With proper clinical management, most chronic wound healing problems can be resolved and healing expected, though recurrence may be common. The recent logarithmic growth in our knowledge about wound healing and the appreciation of the importance of a moist environment in optimal wound healing has led to the introduction of new and exciting therapeutic modalities. In view of the many practical disadvantages as well as the serious complications of currently available moisture retentive dressings when applied to chronic contaminated wounds, a prospective multicenter clinical trial was conducted from December 1999 to November 2000 to evaluate the safety and efficacy of a newly introduced moisture retentive ointment (MEBO: Moist Exposed Burn Ointment (Julphar - Gulf Pharmaceutical Industries, UAE in the local wound care of problematic non-healing wounds. The active component of the ointment is β-sitosterol in a base of beeswax, sesame oil and other components. Though it was not a comparative study, the ointment was found to induce rapid reduction in ulcer size even after a prolonged stagnant state with other therapeutic modalities without complications such as skin maceration, unmanageable excessive exudation, and wound infection. As expected with such chronic wounds, the healing potential of local ointment application is limited by the mere size of the original defect and the underlying pathologies and associated diseases. however, the safety and practicality of simple ointment application was found to be a valid alternative treatment for local management of chronic wounds.

  8. Side effects of glyceryl trinitrate ointment for primary dysmenorrhea: a randomized clinical trial

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    Rahnama P.

    2008-03-01

    Full Text Available Background: Patch forms of glyceryl trinitrate (GTN, also known as nitroglyceril, have proved useful in the management of dysmenorrhea. Increased intrauterine pressure due to exaggerated myometrial contractions is an important factor in the pathogenesis of dysmenorrhea. In a recent study, it was found that GTN caused a significant reduction in the contraction frequency of human myometrial strips. The object of this study is to evaluate the efficacy of GTN ointment in treating primary dysmenorrhea.Methods: In this double-blind randomized placebo-controlled study, we enrolled 112 unmarried subjects with the complaint of moderate to severe primary dysmenorrhea. They were between 18-30 years of age with normal BMI (19-27 and all had normal results upon examination by pelvic ultrasound. None of these patients had a history anemia, previous pelvic surgery or cardiovascular diseases. Randomly divided in two groups using odd and even numbers, 56 of the subjects received 5 mg 1% GTN ointment and another 56 received a placebo. Before starting the treatment, severity of pain was recorded using a visual scale method. Ointment A (GTN 1% or ointment B (placebo was applied to special papers which were in turn applied to the skin of the abdomen below the umbilicus, and left there for the entire treatment period of four hours. The severity of pain and side effects of the treatment were recorded at intervals of 15 min, 30 min, 1 h, 2 h and 4 h after application the treatment. After four hours, the treatment was removed and the skin checked for erythema. Results: There was no difference in severity of pain 15 min after treatment, but pain was less severe in the GTN group from the 30-min interval through the 4-h interval, with the least pain felt at the 2-h interval. This decrease in pain lasted through the 4-h interval. Side effects, which were more common in the GTN group than the placebo group (P<0.05, included headache (48.3% vs. 19.5%, respectively, dizziness

  9. Use of tacrolimus ointment in vitiligo alone or in combination therapy.

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    Berti, S; Buggiani, G; Lotti, T

    2009-05-01

    Current treatments for vitiligo are largely unsatisfactory. Topical corticosteroids and phototherapy (narrow-band UVB and psoralen+UVA) are the most prescribed, however, these therapies are often not effective and have important side-effect, especially when used for a long time. Many studies have reported the efficacy and safety of tacrolimus ointment in adults and children with vitiligo, particularly when located on the head and neck. Successful treatment is possible when it is combined with other therapies, such as narrow-band UVB, microphototherapy, helium-neon laser, or narrow-band excimer laser.

  10. Plasma cell cheilitis, successfully treated with topical 0.03% tacrolimus ointment.

    Science.gov (United States)

    Jin, Seon Pil; Cho, Kwang Hyun; Huh, Chang Hun

    2010-05-01

    Plasma cell cheilitis is a rare, idiopathic mucosal condition. The treatment of plasma cell cheilitis is often disappointing. It is often resistant to various topical treatments. We present a 65-year-old woman who had a painful, eroded area on her lower lip, which responded poorly to various topical treatments. A biopsy revealed a band-like infiltration composed mainly of plasma cells in the dermis. She was diagnosed as having plasma cell cheilitis, and was successfully treated with 0.03% topical tacrolimus ointment.

  11. STUDY OF ANTIMICROBIAL ACTIVITY OF NEW COMBINED OINTMENT ON THE MODEL OF PURULENT WOUND OF STAPHYLOCOCCAL ETIOLOGY

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    Tkachova O.V.

    2015-05-01

    Full Text Available Introduction. Prevalence of purulent pathologies and insufficient number of combined ointments with multi-effect on inflammation, infection and tissue damage are a prerequisite for scientists of NUPh to develop a new combined ointment composed of: antiseptics ethacridine lactate and thick chlorophyllipt extract, drug with reparative and anti-inflammatory activity – dexpanthenol, PEG-base of the IInd generation with the moderate dehydrating activity (180%. The range of pharmacological actions of Filetol ointment meets local therapy requirements in the IInd phase of the wound healing process. New ointment can also be applied in the Ist phase of wound healing process, if the wound contains a small amount of purulent exudate or does not contain it at all. Material & Methods. The purulent wound of staphylococcal etiology was reproduced in 24 white mature female mice weighing 14-17 g and subcutaneously injected with 0.2 ml of 10% solution of calcium chloride in the skin area, depilated beforehand, and after the development of necrosis on the 4th day injected with 0.2 ml of daily agar cultures S. aureus ATCC 25923 in the necrotizing area. In 48 hours of the infection, in the area of administration of staphylococcus cultures purulent necrotic wounds developed, which, depending on the size and intensity of the lesions, were subjected to reverse development in 9-15 days in a row. Animals were divided into three groups of 8 animals, including a positive control group, animals in which were not treated. In this study, the comparator was Levomecol ointment which is widely used in clinical practice for the local treatment of purulent wounds. Efficacy of treatment was evaluated on the basis of lesion value and intensity in study groups compared with the positive control, animal deaths in the case of generalization of the purulent process, quantitative dynamics of microorganisms in the wound and planimetric indicators (area of wounds and the percentage of

  12. Comparison of the Effects of Chamomile and Calendula Ointments on Diaper Rash

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    Zahra Afshari

    2015-06-01

    Full Text Available Background: Diaper Rash is a common skin disorder in the infancy that makes infants and their parents anxious and nervous. Due to the high prevalence of dermatitis and its complications in addition to adverse effects of chemical drugs, herbal therapy is an appropriate solution. Aim: Comparison of the effects of Chamomile and Calendula ointments on severity of Diaper Rash. Methods: This double-blind randomized controlled trial was conducted on 90 infants under one year who were hospitalized in Sabalan Hospital of Ardebil. The infants were treated by Chamomile and Calendula ointments for one week. The severity of dermatitis was evaluated on days one, 3 and 7.  In order to assess the severity of dermatitis, the checklist of Diaper Rash five-point scale was used. Data were analyzed by software SPSS version 14 using chi-square, ANOVA, T-Test. Results: The age in the Chamomile group was (8. 8 ± 2.3 and in Calendula group was (9.0± 2.4 months. The severity of dermatitis in Chamomile group before treatment was 1.6 ± 0.5, on the third day 0.8 ± 0.4, and on the seventh day zero (p

  13. Combination Ointment Containing Solid Tranilast Nanoparticles and Dissolved Sericin Is Efficacious for Treating Skin Wound-Healing Deficits and Redness in Diabetic Rats.

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    Nagai, Noriaki; Ogata, Fumihiko; Deguchi, Saori; Ueno, Akina; Kawasaki, Naohito; Ito, Yoshimasa

    2017-01-01

    We attempted to design a combination ointment containing solid tranilast nanoparticles and dissolved sericin as a wound-healing drug (TS-combination ointment), and evaluated its usefulness as therapy for wound-healing deficits in streptozotocin-induced diabetic rat (STZ rat) using kinetic analyses as an index. Solid tranilast nanoparticles were prepared by bead mill methods with low-substituted methylcellulose; the mean particle size of the tranilast nanoparticles was 70 nm. The ointment was designed to contain the tranilast nanoparticles plus sericin powder and/or Carbopol(®) 934. Skin wound healing in STZ rats begins significantly later than in normal rats. Although the skin wound healing rate in STZ rats treated with an ointment containing tranilast nanoparticles was lower than in STZ rats treated with vehicle, the ointment was effective in reducing redness. An ointment containing sericin enhanced the skin-healing rate, but the preventive effect on redness was weak. On the other hand, the combination of tranilast and sericin increased both the skin healing rate and reduction in redness. In conclusion, we have adapted kinetic analyses to skin wound healing in rats, and found these analyses to be useful as an index of wound healing ability by a wound-healing drug. In addition, we show that treatment with the TS-combination ointment enhances the skin wound healing rate and reduces redness. These findings provide information significant to the search for new wound-healing therapies and for the design of wound-healing drugs.

  14. Amish Culture and Their Utilization of Burns and Wounds Ointment for the Treatment of Burns.

    Science.gov (United States)

    Trinkle, Krystal Melich

    2016-01-01

    As indicated in the 2010 United States Religion Census, there are approximately 251,000 Amish people in the United States and Ontario. This census also demonstrated that a new Amish community is founded on average about every three-and-a-half weeks, suggesting that this religious culture is the fastest-growing religion throughout the United States. Because of the rapid growth of the Amish population, it is essential for health care workers to understand their background, cultural, and health care beliefs, especially in the treatment of burns. The purpose of this article is to examine the Amish background, cultural, and health care beliefs, specifically the utilization of burns and wounds ointment and burdock leaves in the treatment of burns.

  15. Evaluation of wound healing effects between Salvadora persica ointment and Solcoseryl jelly in animal model.

    Science.gov (United States)

    Imran, Hina; Ahmad, Mansoor; Rahman, Atiqur; Yaqeen, Zahra; Sohail, Tehmina; Fatima, Nudrat; Iqbal, Wasif; Yaqeen, Syed Shafay

    2015-09-01

    In this research study very first time a herbal ointment contain 10% Salvadora persica extract was compared with Solcosseryl jelly 10% and blank Vaseline to evaluate wound healing effects using excision wound healing model in animals. Three groups of rats (n-6) were experimentally wounded on the back of their neck. Group I was dressed with Vaseline containing 10% test drug, Group II was treated with thin layer of Solcoseryl jelly 10% as reference drug while Group III was dressed with thin layer of blank Vaseline as control group. The effect of vehicle on rate of wound healing were assessed and in all cases there were progressive decreased in wound area with time but wound dress with Vaseline containing S. persica extract and wound treated with Solcosseryl jelly significantly healed earlier than those treated with Vaseline. It is concluded that S. persica extract significantly enhance the acceleration rate of wound enclosure in rats.

  16. A comparative clinical study of sisomicin cream versus mupirocin ointment in pyodermas

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    Oberai Chetan

    2002-01-01

    Full Text Available This study was designed to compare the efficacy and safety of sisomicin cream (0.1% or mupirocin ointment (2% in the treatment of primary or secondary pyodermas requiring topical antibiotic therapy alone. In the evaluable patients (n=290, impetigo was the commonest clinical condition reported. Staphylococcus aureus was the commonest pathogen isolated from the lesons. Both sisomicin and mupirocin treatments produced a steady improvement in the scores of erythema, oedema, vesiculation, pustulation, crusting and scaling but the improvement produced by sisomicin was quicker and more pronounced. The percentage of patients with complete clearing of all lesions was also higher with sisomicin than with mupirocin on days 4, 8 and 14. Patients subjectively rated the sisomicin formulation as excellent in 75% of cases as against 59% with mupirocin. Sisomicin and mupirocin are effective and safe in the management of pyodermas; however sisomicin therapy resulted in faster and greater relief of signs and symptoms.

  17. The carcinogenic potential of tacrolimus ointment beyond immune suppression: a hypothesis creating case report

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    Vetter Claudia S

    2006-01-01

    Full Text Available Abstract Background Since tacrolimus ointment was approved by the U.S. Food and Drug Administration (FDA as a promising treatment for atopic dermatitis, it has been approved in more than 30 additional countries, including numerous European Union member nations. Moreover, in the current clinical routine the use of this drug is no longer restricted to the approved indication, but has been extended to a wide variety of inflammatory skin diseases including some with the potential of malignant transformation. So far, the side-effects reported from the topical use of tacrolimus have been relatively minor (e.g. burning, pruritus, erythema. Recently, however, the FDA reviewed the safety of topical tacrolimus, which resulted in a warning that the use of calcineurin inhibitors may be associated with an increased risk of cancer. Case presentation Oral lichen planus (OLP was diagnosed in a 56-year-old women in February 1999. After several ineffective local and systemic therapeutic measures an off-label treatment of this recalcitrant condition using Tacrolimus 0.1% ointment was initiated in May 2002. After a few weeks of treatment most of the lesions ameliorated, with the exception of the plaques on the sides of the tongue. Nevertheless, the patient became free of symptoms which, however, reoccurred once tacrolimus was weaned, as a consequence treatment was maintained. In April 2005, the plaques on the left side of the tongue appeared increasingly compact and a biopsy specimen confirmed the suspected diagnosis of an oral squamous cell carcinoma. Conclusion The suspected causal relationship between topical use of tacrolimus and the development of a squamous cell carcinoma prompted us to test the notion that the carcinogenicity of tacrolimus may go beyond mere immune suppression. To this end, tacrolimus has been shown to have an impact on cancer signalling pathways such as the MAPK and the p53 pathway. In the given case, we were able to demonstrate that these

  18. Comparative Efficacy of Topical Pertmehrin, Crotamiton and Sulfur Oint-ment in Treatment of Scabies

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    Celestyna Mila-Kierzenkowska

    2017-04-01

    Full Text Available Background:  Scabies is an ectoparasitic infection, which occurs because of direct skin-to skin contact. The ideal treatment modality is still unclear and further research on this topic is warranted. The aim of the study was to com­pare the efficacy and safety of the topical scabicides: permethrin, crotamiton and sulfur ointment.Methods: Fifty four patients with diagnosed scabies were randomly divided into three treatment groups. The first group received 5% permethrin cream twice with one week interval, the patients from the second group were given crotamiton lotion for two days twice with one week interval, while the third group received 10% sulfur ointment for two or three weeks. All patients were followed up at 1, 2 and 4 weeks intervals.Results: At one-week follow up the cure rate was significantly higher at permethrin-treated group when compared to crotamiton group (P< 0.001 and sulfur group (P< 0.001. At the end of two-week interval, the cure rate at perme­thrin group was 100%, while at crotamiton group, 66.7% and in sulfur group 38.9% (P< 0.001. At 4-week follow up the applied treatment was effective in all studied individuals.Conclusion: The topical application of permethrin, crotamiton and sulfur was equally efficacious at 4-week follow up, however permethrin cream showed faster improvement at first and second follow up. Acquiring permethrin is considered as expensive option and crotamiton lotion seems to be cost-less alternative to this cream.

  19. Estabilidad acelerada del ungüento QL Accelerated stability of QL ointment

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    Yania Suárez Pérez

    2008-04-01

    Full Text Available El ungüento QL es un ungüento rectal en fase de investigación destinado al tratamiento de afecciones rectales. La combinación por primera vez de quitina y clorhidrato de lidocaína en un producto semisólido de base oleaginosa, requiere del estudio del comportamiento de estabilidad. Para obtener información con respecto a su estabilidad se realizó un estudio en las condiciones establecidas. Se analizaron 3 lotes pilotos QL01, QL02 y QL03, almacenados a temperatura de 40 ± 2 °C. Los estudios se realizaron a tiempo 0, 1, 2, 3, 6 meses. No se observaron cambios en las propiedades organolépticas, en la estabilidad sedimentacional, ni en el área de extensibilidad. Se mantuvo el flujo pseudoplástico tixotrópico característico de este tipo de sistema al cabo de los 6 meses. Los principios activos se mantuvieron estables en las condiciones ensayadasQL ointment is a rectal ointment under development stage devoted to the treatment of rectal affections. The combination for the first time of quitine and lydocaine chloride in a semisolid product of oleaginous base requires the study of the stability behaviour. To obtain information on its stability, a study was carried out under the established conditions. 3 pilot batches QL01, QL02 and QL03, stored at a temperature of 40 2 C, were analyzed. The studies were conducted at 0, 1, 2, 3 and 6 months. No changes were observed neither in the organoleptic properties, nor in the sedimentation stability and the extensibility area. The pseudoplastic thixotropic flow characteristic of this type of system was maintained after 6 months. The active principles were stable under the assayed conditions

  20. Safety and efficacy of loteprednol etabonate ophthalmic ointment 0.5% for the treatment of inflammation and pain following cataract surgery

    Directory of Open Access Journals (Sweden)

    Timothy L Comstock

    2011-02-01

    Full Text Available Timothy L Comstock1 Michael R Paterno1 Angele Singh1 Tara Erb1 Elizabeth Davis21Bausch and Lomb Inc., Rochester, NY, USA; 2Minnesota Eye Consultants, Bloomington, MN, USABackground: To compare the safety and efficacy of loteprednol etabonate ophthalmic ointment 0.5% (LE ointment, a new topical ointment formulation, with vehicle for the treatment of inflammation and pain following cataract surgery.Methods: Two randomized, multicenter, double-masked, parallel-group, vehicle-controlled studies were conducted. Patients aged ≥18 years with a combined postoperative anterior chamber cells and flare (ACI ≥ Grade 3 following uncomplicated cataract surgery participated in seven study visits. Patients self-administered either topical LE ointment or vehicle four times daily for 14 days. Efficacy outcomes included the proportion of patients with complete resolution of ACI and the proportion of patients with no (Grade 0 pain at postoperative day 8. Safety outcomes included the incidence of adverse events, ocular symptoms, changes in intraocular pressure and visual acuity, and biomicroscopy and funduscopy findings.Results: Data from the two studies were combined. The integrated intent-to-treat population consisted of 805 patients (mean [standard deviation] age 69.0 [9.2] years; 58.0% female and 89.7% white. Significantly more LE ointment-treated patients than vehicle-treated patients had complete resolution of ACI (27.7% versus 12.5% and no pain (75.5% versus 43.1% at day 8 (P < 0.0001 for both. Fewer LE ointment-treated patients required rescue medication (27.7% versus 63.8%, and fewer had an ocular adverse event (47.2% versus 78.0%, P < 0.0001 while on study treatment. The most common ocular adverse events with LE ointment were anterior chamber inflammation, photophobia, corneal edema, conjunctival hyperemia, eye pain, and iritis. Mean intraocular pressure decreased in both treatment groups. Four patients had increased intraocular pressure ≥10 mm

  1. Effects of mixing procedure itself on the structure, viscosity, and spreadability of white petrolatum and salicylic acid ointment and the skin permeation of salicylic acid.

    Science.gov (United States)

    Kitagawa, Shuji; Fujiwara, Megumi; Okinaka, Yuta; Yutani, Reiko; Teraoka, Reiko

    2015-01-01

    White petrolatum is a mixture of solid and liquid hydrocarbons and its structure can be affected by shear stress. Thus, it might also induce changes in its rheological properties. In this study, we used polarization microscopy to investigate how different mixing methods affect the structure of white petrolatum. We used two different mixing methods, mixing using a rotation/revolution mixer and mixing using an ointment slab and an ointment spatula. The extent of the fragmentation and dispersal of the solid portion of white petrolatum depended on the mixing conditions. Next, we examined the changes in the structure of a salicylic acid ointment, in which white petrolatum was used as a base, induced by mixing and found that the salicylic acid solids within the ointment were also dispersed. In addition to these structural changes, the viscosity and thixotropic behavior of both test substances also decreased in a mixing condition-dependent manner. The reductions in these parameters were most marked after mixing with a rotation/revolution mixer, and similar results were obtained for spreadability. We also investigated the effects of mixing procedure on the skin accumulation and permeation of salicylic acid. They were increased by approximately three-fold after mixing. Little difference in skin accumulation or permeation was detected between the two mixing methods. These findings indicate that mixing procedures themselves affect the utility and physiological effects of white petrolatum-based ointments. Therefore, these effects should be considered when mixing is required for the clinical use of petrolatum-based ointments.

  2. 黄膏治疗特应性皮炎患者的效果%Herbal Ointment Improves Troubles in Atopic Dermatitis in Not Only NC/Nga Mice Also Atopic Dermatitis Patients.- Which impressions of the ointments stimulate patients? -

    Institute of Scientific and Technical Information of China (English)

    日置智津子

    2010-01-01

    @@ Background:A subset of common chronic skin condition demonstrates severe atopic dermatitis that is refractory to conventional treatment with topical steroids.The patients on atopic dermatitis (AD)using the Ou-kou (黄膏;a novel herbal ointment)has been shown improved skin condition and better quality of life (QOL).Objective and Methods:This study aimed to show the effect, in mental and skin conditions, of the administration of Ou- kou on atopic dermatitis patients.

  3. RESEARCH OF UV-PROTECTIVE ACTIVITY OF FERULIC ACID AS PART OF OINTMENT COMPOSITIONS WITH DIFFERENT PHYSICAL AND CHEMICAL PROPERTIES

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    I. L. Abisalova

    2014-01-01

    Full Text Available Cosmetics with the ability to neutralize harmful influence of ultraviolet rays on skin are quite in demand. UV filters in creams composition are divided into two groups: physical and chemical. Antioxidants are used as chemical UV filters. The article presents the results of ferulic acid testing as UV filter in ointment bases with lipophile, hydrophile and lipophilic and hydrophilic properties. The dependence of ferulic acid efficiency from the base type where it was applied was established. The results received are correlated with data about release rate of ferulic acid received in vitro. Ointment bases with such emulsifiers as cetyl alcohol, base emulsifier and Olivem 1000 have the most signified UV protective effect of ferulic acid.

  4. Physicochemical characterization of tretinoin tocoferil emulsion and povidone-iodine sugar ointment blend developed for improved regulation of wound moisture.

    Science.gov (United States)

    Noda, Yasuhiro; Saito, Mika; Watanabe, Kazuya; Sanagawa, Akimasa; Sobajima, Yu; Fujii, Satoshi

    2013-01-01

    Maintenance of proper moisture and regulation of infection are simultaneously required to promote healing of pressure ulcers. Continuous use of water-rich ointment may often lead to excess moisture and induce edematous granulation tissue. Use of water soluble ointment may excessively absorb exudates and induce dry granulation tissue. Selection of appropriate topical ointment is desired to avoid worse clinical outcomes. For adjustment of wound moisture a novel blended ointment (tretinoin tocoferil-povidone-iodine (TR-PI)) was developed consisting of emulsion base, tretinoin tocoferil oil-in-water (o/w) emulsion (TR-cream), and sugar base, povidone-iodine and sugar (PI-sugar). For the characterization of TR-PI water absorption was tested using Franz diffusion cell with cellulose membrane. For rheological characteristics spreadability was tested using spread meter and yield value was calculated. Iodine permeation was tested using a permeation cell with silicon membrane. Water absorption rate constant of TR-PI with combination ratio of PI-sugar at 75% (TR-PI75, 18.5 mg cm(-2) min(-0.5)) was equivalent to that of TR-cream alone (16.4 mg cm(-2) min(-0.5)). The yield value of TR-PI75 (26.1 Pa) exhibited intermediate values as compared to those of TR-PI with combination ratio of PI-sugar at 50% (11.3 Pa) and TR-cream alone (46.8 Pa). The amount of released free-iodine from TR-PI75 was similar to that released from PI-sugar alone. TR-PI75 may have superior performance in keeping the moist environment in wounds and in preventing infection. TR-PI75 can be used to promote formation of favorable granulation tissue in pressure ulcers with moderate exudates.

  5. A Double-Blind Randomized Placebo-Controlled Clinical Trial of Squalamine Ointment for tinea capitis Treatment

    OpenAIRE

    2015-01-01

    International audience; Background Novel treatments against for tinea capitis are needed, and the natural aminosterol squal-amine is a potential topical antidermatophyte drug candidate. Objectives This phase II randomized double-blind placebo-controlled clinical trial aimed at testing the efficacy and safety of a three-week squalamine ointment regimen for the treatment of tinea capitis. Patients Males aged 6–15 years presenting with tinea capitis were treated with either topical squal-amine o...

  6. Efficacy of topical application of 0.03% tacrolimus eye ointment in the management of allergic conjunctivitis

    OpenAIRE

    Hazarika, Ajit Kumar; Singh, Prodip Kumar

    2015-01-01

    Background: Allergic conjunctivitis is commonly observed eye diseases in Sikkim, India due to the abundance of seasonal pollens, environmental pollutants, and house dust. We evaluated the efficacy of topical 0.03% tacrolimus eye ointment in the management of simple allergic conjunctivitis. Materials and Methods: A prospective observational study was designed consisting of 41 patients with refractory simple allergic conjunctivitis, whose condition responded very poorly to conventional anti-all...

  7. Chinese Massage Combined with Herbal Ointment for Athletes with Nonspecific Low Back Pain: A Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Ling Jun Kong

    2012-01-01

    Full Text Available Non-specific low back pain (NLBP is an increasing health problem for athletes. This randomized controlled trial was designed to investigate the effects of Chinese massage combined with herbal ointment for NLBP. 110 athletes with NLBP were randomly assigned to experimental group with Chinese massage combined with herbal ointment or control group with simple massage therapy. The primary outcome was pain by Chinese Short Form McGill Pain Questionnaire (C-SFMPQ. The secondary outcome was local muscle stiffness by Myotonometer. After 4 weeks, the experimental group experienced significant improvements in C-SFMPQ and in local muscle stiffness compared with control group (between-group difference in mean change from baseline, −1.24 points, P=0.005 in sensory scores; −3.14 points, P<0.001 in affective scores; −4.39 points, P<0.001 in total scores; −0.64 points, P=0.002 in VAS; −1.04 points, P=0.005 in local muscle stiffness during relaxation state. The difference remained at one month followup, but it was only significant in affective scores (−2.83 points, P<0.001 at three months followup. No adverse events were observed. These findings suggest that Chinese massage combined with herbal ointment may be a beneficial complementary and alternative therapy for athletes with NLBP.

  8. Moist exposed burn ointment for treating pressure ulcers: A multicenter randomized controlled trial.

    Science.gov (United States)

    Li, Wei; Ma, Yubo; Yang, Qi; Pan, Yu; Meng, Qinggang

    2017-07-01

    Pressure ulcers often seriously affect the quality of life of patients. Moist Exposed Burn Ointment (MEBO) has been developed to treat patients with pressure ulcers. The present study aimed to evaluate the efficacy and safety of MEBO in the treatment of pressure ulcers in Chinese patients. Seventy-two patients with pressure ulcers were randomly assigned to 2 groups who received a placebo or MEBO for 2 months. The primary outcomes included the wound surface area (WSA) and pressure ulcer scale for healing (PUSH) tool. The secondary outcomes included a visual analog scale (VAS), questionnaire of ulcer status, and adverse effects. Sixty-seven patients completed the study. After 2 months of treatment, the difference of mean change from the baseline was greater for MEBO (vs placebo) for WSA mean (SD) -6.0 (-8.8, -3.3), PUSH Tool -2.6 (-4.7, -1.5), and VAS score -2.9 (-4.4, -1.7). On the basis of the questionnaire, the pressure ulcers were "completely healed" (50.0% vs 16.7%) (P pressure ulcers.

  9. Effects of maxacalcitol ointment on skin lesions in patients with psoriasis receiving treatment with adalimumab.

    Science.gov (United States)

    Karakawa, Masaru; Komine, Mayumi; Kishimoto, Megumi; Maki, Nobuki; Matsumoto, Ai; Sugai, Junichi; Ohtsuki, Mamitaro

    2016-11-01

    Adalimumab is a biologic that is very effective for treatment of psoriasis. However, recalcitrant or recurrent lesions sometimes occur during treatment. Maxacalcitol is an active vitamin D3 ointment that is effective in treatment of psoriasis. Topical therapy may be beneficial in treatment of recalcitrant or recurrent lesions during treatment with systemic therapy, but there is little evidence on this topic. We investigated the effect of maxacalcitol on skin lesions during treatment with adalimumab in patients with psoriasis. Twelve patients with psoriasis were randomly assigned to two groups after informed consent - treatment with adalimumab only (n = 6), and treatment with adalimumab and maxacalcitol (n = 6) - and they were evaluated every 4 weeks for 44 weeks. Exacerbation was defined as an increase of the Psoriasis Area and Severity Index (PASI) score. The interval between adalimumab treatments was elongated to 3-4 weeks from 2 weeks according to the individual patient's condition. The PASI score was evaluated every 4 weeks, and the frequency of exacerbations was counted. The overall improvement in PASI score was not statistically different between the two groups, but the frequency of exacerbations was significantly less in the maxacalcitol combination group compared with the adalimumab monotherapy group (Mann-Whitney U-test, P psoriasis when used in combination with adalimumab. © 2016 Japanese Dermatological Association.

  10. 2种前处理工艺对黄白痤疮膏药效的影响%Effect of 2 processing technologies on Huangbai acne ointment

    Institute of Scientific and Technical Information of China (English)

    彭学著; 屈双; 成丁茂; 刘晓艳; 肖超群; 雷玉翠

    2012-01-01

    目的 优化黄白痤疮膏的制备工艺.方法 选用成年雄性金黄地鼠侧腹部皮脂腺斑作为实验模型,随机分成3组,分别采用粉末制软膏、流浸膏制软膏、空白对照软膏涂敷皮脂腺斑30 d,观察皮脂腺斑大小的变化.结果 2种黄白痤疮膏跟空白软膏相比,金黄地鼠皮脂腺斑明显缩小,有显著性差异(P<0.01);而流浸膏制黄白痤疮膏与粉末制黄白痤疮膏相比,作用更强,结果有显著性差异(P<0.05).结论 2种前处理工艺制备的黄白痤疮膏均有较好疗效,其中流浸膏制比粉末制疗效更佳,涂展性也更好.%Objective To optimize the preparation method for Huangbai acne ointment. Methods Golden hamsters, as animal model for the test, were randomly divided into 3 groups. Powder preparation ointment, liquid extract preparation ointment, and blank ointment for external application were used respectively on the gland spot of golden hamster side stomach for 30 d, and the size of gland spot was observed. Results Compared with blank ointment, powder preparation ointment and liquid extract preparation ointment obviously reduced the area of gland spot (P<0. 01). Liquid extract preparation ointment had better effect on the gland spot than powder preparation ointment (P<0. 05). Conclusion Both pretreatments for preparation of Huangbai acne have good effect. Liquid extract preparation has better effect as well as proper ductility than powder preparation.

  11. Improvement of erythema dyschromicum perstans using a combination of the 1,550-nm erbium-doped fractionated laser and topical tacrolimus ointment.

    Science.gov (United States)

    Wolfshohl, Jon A; Geddes, Elizabeth R C; Stout, Ashlyn B; Friedman, Paul M

    2017-01-01

    Erythema dyschromicum perstans (EDP) is a cosmetically distressing, acquired pigmentary disorder of unknown etiology for which few successful therapies exist. Herein, we present the successful use of non-ablative fractional photothermolysis in combination with topical tacrolimus ointment. A 35-year-old female with biopsy-confirmed EDP underwent a series of fractionated non-ablative treatment sessions utilizing the 1,550 nm erbium-doped fiber laser in combination with topical tacrolimus ointment over a period of 5 months. The patient's EDP improved by greater than 75% and results were maintained at the 8-month follow-up visit. The combination of non-ablative fractional photothermolysis and topical tacrolimus ointment is a potential safe and effective therapeutic option for erythema dyschromicum perstans. Additional prospective, comparative studies are warranted. Lasers Surg. Med. 49:60-62, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  12. Estudio de vida útil del ungüento QL Useful life study of QL ointment

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    Yania Suárez Pérez

    2007-12-01

    Full Text Available El ungüento QL es un nuevo medicamento en fase de desarrollo destinado al tratamiento del brote hemorroidal agudo. Para su introducción en la terapéutica es indispensable comprobar su estabilidad física y química. Los estudios de vida útil se realizaron según las exigencias actuales, para lo cual se analizaron 3 lotes pilotos QL01, QL02 y QL03, almacenados a temperatura ambiente, de refrigeración y temperatura controlada. Los estudios se realizaron a tiempo 0, 1, 2, 3, 6 y 12 meses. No se observaron cambios en las propiedades organolépticas ni en el área de extensibilidad. Se mantuvo el flujo pseudoplástico tixotrópico característico de este tipo de sistema al cabo de los 6 meses. Los principios activos: quitina y clorhidrato de lidocaína, se mantuvieron estables en el tiempo para todas las condiciones de almacenamiento evaluadasQL ointment is a new drug under development stage used to treat the acute hemorrhoidal outbreak. To introduce it in the therapeutics,it is necessary to prove its physical and chemical stability. The useful life studies were conducted according to the current demands. To this end, 3 pilot batches, QL01, QL02 y QL03, stored at room temperature at controlled refrigeration and temperature, were analyzed. The studies were undertaken at 0, 1, 2, 3, 6, and 12 months. No changes were observed neither in the organoleptic properties, nor in the extensibility area. The pseudoplastic tixotropic flow characteristic of this type of system was maintained at 6 months. The active principles chitin and lidocaine chlorhydrate were steady in time for all the storing conditions evaluated

  13. Perbandingan Penyembuhan Luka Bakar Derajat Dua antara Rebusan Daun Sirih dan Moist Exposed Burn Ointment

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    Ihsan

    2012-06-01

    Full Text Available The use of topical agent is one of the main strategies in management of burn injury. At Dr. Hasan Sadikin Hospital, moist exposed burn ointment (MEBO is the first line topical agent for treating burn injury, not all places in Indonesia able to use it. Piper betle is one of the traditional agent to treat wound including that caused burn injury. Our experimental study was to compare the second grade burn injury healing process by using Wistar sp. for boiled piper betle leaves, MEBO and as control physiologic sodium chloride for fourteen days (August 25th–September 8th 2009 at Animal Pharmacology Laboratory of Faculty of Medicine Padjadjaran University. The variables which measured were diameter of injury, pus development, evidence of serous and erythematous skin, at 4th, 7th and 14th day of studied. Histopathologic examination was conducted at day 14 to determine the amount of fibroblast, collagen and epithelial. The results according to the measurement of diameter (piper betle leaves group 17.4 mm was smaller than other groups (p<0.001. In pus development control group was higher than other groups (p=0.043. In pathological findings, the control group was at inflammation phase, while in boiled piper betle leaves group was at proliferation phase and in MEBO group at remodeling phase (with epithel score 1.9 which higher than other groups (p<0.001. In conclusions, application of boiled piper betle leaves in treating second degree burn injury gives a better result than physiologic sodium chloride, although MEBO is better for second degree burn injury healing process.

  14. Qualitative Identification of Piyan Ping Ointment by GC%皮炎平软膏气相色谱鉴别

    Institute of Scientific and Technical Information of China (English)

    张敏

    2001-01-01

    目的:用气相色谱法对皮炎平软膏中薄荷脑、樟脑进行鉴别。方法:采用气相色谱鉴别。结果:简便、快速、准确。结论:可作为该制剂的质控方法之一。%Menthol, camphor of Piyan Ping ointment were qualitativelyanalyzed by GC. This method is simple, fast with exact result. It is one of the quality control methods of this preparation.

  15. Combination treatment of oral terbinafine with topical terbinafine and 10% urea ointment in hyperkeratotic type tinea pedis.

    Science.gov (United States)

    Shi, Tian-Wei; Zhang, Jiang-An; Zhang, Xian-Wei; Yu, Hong-Xing; Tang, Yong-Bo; Yu, Jian-Bin

    2014-09-01

    Hyperkeratotic-type tinea pedis is chronic and recalcitrant to topical antifungal agents. Some topical antifungal agents are effective; however, long duration of therapy is required, which often reduce the treatment compliance of patients. To seek for short period therapy of hyperkeratotic type tinea pedis, in this study, we observed the efficacy and safety of treatment of topical terbinafine and 10% urea ointment combined oral terbinafine. Participants with hyperkeratotic type tinea pedis were randomly assigned to two groups. Patients in group I were treated with oral terbinafine for 2 weeks and topical terbinafine and 10% urea ointment for 4 weeks, whereas in group II, only the above topical agents were applied for 12 weeks. Clinical improvement rates and fungal eradication rates were compared between the two groups at 24 weeks after the initiation of treatment. The group I had stopped the topical therapy 8 weeks earlier than group II. There were no significant differences in mycological eradication rates and clinical improvement rates between the two groups, besides, no major side effects were noted in both groups. The short combination therapy with oral terbinafine was effective and safe; it should be a valuable option for patients with hyperkeratotic type tinea pedis.

  16. Aktivitas Salep Ekstrak Rimpang Kunyit dalam Proses Persembuhan Luka pada Mencit yang Diinduksi Diabetes (THE ACTIVITY OF TURMERIC EXTRACT OINTMENT IN THE WOUND HEALING PROCESS OF INDUCED DIABETIC MICE

    Directory of Open Access Journals (Sweden)

    Wiwin Winarsih

    2013-07-01

    Full Text Available The aim of this study was to evaluate the effectiveness of ethanol turmeric extract ointment in woundhealing process of streptozotocin-induced diabetic mice. Ethyl acetate and hexane fractions of ethanolturmeric extract were studied for their wound-healing properties in the formulation of ointment. Sixty micewere divided into 4 groups : group I was control (normal control, without treatment; group II was diabeticgroup (diabetic, without treatment; group III was diabetic and treated with ethyl acetate fraction ointment,group IV was diabetic and treated with hexane fraction ointment. The diabetic groups were i.p injectedwith 40mg/kg of streptozotocin and all groups were received incision 2 cm on their back skin. The ointmentsof ethyl acetate and hexane fraction were given topically twice a day. Three mice from each groups werenecropsied at 2nd, 4th, 7th, 14th and 21st days post incision (pi for gross pathological and histopathologicalevaluation of the injured skin. Gross examination revealed that the ethyl acetate and hexane fractionointment groups showed better result on wound-healing process compared to the diabetic group.Microscopically, the ethyl acetate and hexane fraction ointment groups showed faster neovascularizationand reepithelialization compared to the diabetic group. In comparison with the diabetic group, the ethylacetate and hexane fraction ointment groups showed fewer neutrophils infiltration which indicated antiinflammatory activities of ethyl acetate and hexane fractions. Based on the macroscopic and microscopicobservation, the ointments of ethyl acetate and hexane fraction have properties to promote wound healingin diabetic mice.

  17. A Novel Topical Combination Ointment with Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus, Gram-Negative Superbugs, Yeasts, and Dermatophytic Fungi

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    Kenneth S. Thomson, B.Ag.Sc, MS, PhD

    2016-01-01

    Conclusions: The results of this study suggest that this combination ointment has a broad in vitro spectrum of antimicrobial activity against both more common bacterial and fungal pathogens and may be particularly useful for treatment of infections by multidrug-resistant organisms. Additional studies are warranted to investigate the full clinical utility as a therapeutic agent and also for possible infection control interventions.

  18. The efficacy of mupirocin ointment and chlorhexidine body scrubs in the eradication of nasal carriage of Staphylococcus aureus among patients undergoing long-term hemodialysis

    NARCIS (Netherlands)

    C. Watanakunakorn; J. Brandt; P. Durkin; S. Santore; B. Bota; C. J. Stahl

    1992-01-01

    textabstractPatients undergoing long-term hemodialysis have a high prevalence of Staphylococcus aureus nasal carriage, which may lead to serious infections. Mupirocin ointment has been used intranasally to eradicate S. aureus carriage in health human volunteers and health care workers. Chlorhexidine

  19. Clinical and bacteriological efficacy of twice daily topical retapamulin ointment 1% in the management of impetigo and other uncomplicated superficial skin infections

    Directory of Open Access Journals (Sweden)

    Benjamin R. Bohaty, MD

    2015-02-01

    Conclusion: Safety profile appears favorable given the low number of AEs. Study design limits conclusions that can be drawn. Nevertheless, this study supports use of topical retapamulin 1% ointment in treatment of cutaneous bacterial infections, particularly those caused by S. aureus, including MRSA.

  20. Calcipotriol/betamethasone dipropionate ointment in mild-to-moderate paediatric psoriasis: long-term daily clinical practice data in a prospective cohort

    NARCIS (Netherlands)

    Geel, M.J. van; Mul, K.; Oostveen, A.M.; Kerkhof, P.C. van de; Jong, E.M. de; Seyger, M.M.B.

    2014-01-01

    BACKGROUND: Psoriasis in children has a significant negative impact on the quality of life (QoL) and effective treatment can improve this. The two-compound ointment calcipotriol 50 mug g(-1) and betamethasone dipropionate 0.5 mg g(-1) is an effective treatment option for moderate-to-severe psoriasis

  1. Chinese herbal Pulian ointment in treating psoriasis vulgaris of blood-heat syndrome: a multi-center, double-blind, randomized, placebo-controlled trial.

    Science.gov (United States)

    Li, Nuo; Zhao, Wenbin; Xing, Jianmin; Liu, Jianping; Zhang, Guangzhong; Zhang, Yunbi; Li, Yuanwen; Liu, Wali; Shi, Fei; Bai, Yanping

    2017-05-15

    Traditional Chinese medicine (TCM) has a long history in the treatment of psoriasis vulgaris. We aimed to evaluate the clinical efficacy and safety of Chinese herbal Pulian ointment in treating psoriasis vulgaris of blood-heat syndrome. A multicenter, randomized, double-blind, placebo-controlled trial was conducted. Participants with psoriasis vulgaris of blood-heat syndrome were blinded and randomized to receive Pulian ointment or placebo ointment twice daily for 4 weeks, with follow-up 8 weeks after treatment. Psoriasis Area Severity Index (PASI) scores, severity of each symptom and area of skin lesion and quality of life were assessed at baseline, 2 weeks, and 4 weeks. Adverse events were recorded during the study. SAS 9.4 software and SPSS 17.0 software was applied for data analysis. A total of 300 participants with psoriasis vulgaris of blood-heat syndrome were assessed for eligibility, and 294 were randomly assigned to the Pulian ointment and placebo group from six study centers. Full analysis set (FAS): after 4 weeks of treatment, there were significant differences between groups in PASI score and the separate score of skin lesion area, favoring Pulian ointment group (P  0.05). Per protocol set (PPS): There was no statistically significant difference in PASI score and separate score of each symptom and area of skin lesion between two groups (P > 0.05). Quality of life measured by Hamilton Anxiety Rating Scale (HAMA) and 36-Item Short Form Health Survey (SF-36) improved after treatment in both groups, but there was no significant difference between the two groups (P > 0.05). After being followed up for 8 weeks, the total relapse rates of the Pulian Ointment group and placebo group were 5.88 and 8.45%, respectively, and the difference was not statistically significant between the two groups (P > 0.05). No adverse event was observed in both groups throughout the study. Pulian Ointment seems effective and well tolerated in improving the

  2. Curative effect Observation of Long Zhu ointment after anorectal surgery%肛肠疾病术后应用龙珠软膏的疗效观察

    Institute of Scientific and Technical Information of China (English)

    王庆杰; 李丽; 刘艳茹

    2014-01-01

    Objective:To explore the therapeutic effect of Long Zhu ointment on wound healing after anorectal surgery.Methods:610 cases of anorectal surgery were selected.We evenly covered the postoperative wound of the hemorrhoids,anal fissure,perianal abscess,anal fistula with Long Zhu ointment,or took Long Zhu ointment gauze into the anus.We compared the wound healing situation,symptoms and syndromes of patients before and after the treatment.Results:Long Zhu ointment can promote the wound healing of hemorrhoids,perianal abscess,anal fissure after the operation.The rate of significant efficiency were 98.5%,98%,97.6%respectively.Conclusion:Long Zhu ointment can promote wound healing after anorectal postoperative.%目的:探讨龙珠软膏对肛肠疾病术后创面愈合的治疗效果。方法:选择肛肠病手术患者610例,将龙珠软膏均匀涂抹覆盖在痔、肛裂、肛周脓肿、肛瘘术后创面上,或将龙珠软膏纱条塞入肛内,对患者用药前后创面愈合状况、症状及体征进行比较。结果:龙珠软膏促进痔疮、肛周脓肿、肛瘘术后创面愈合,显效率分别为98.5%、98%、97.6%。结论:龙珠软膏能有效地促进肛肠病术后创面愈合。

  3. [Aural Stimulation with Capsaicin Ointment Improved the Swallowing Function in Patients with Dysphagia: Evaluation by the SMRC Scale].

    Science.gov (United States)

    Kondo, Eiji; Jinnouchi, Osamu; Ohnishi, Hiroki; Kawata, Ikuji; Takeda, Noriaki

    2015-11-01

    Cough and swallowing reflexes are important airway-protective mechanisms against aspiration. Angiotensin-converting enzyme (ACE) inhibitors, one of the side effects of which is cough, have been reported to reduce the incidence of aspiration pneumonia in hypertensive patients with stroke. ACE inhibitors have also been reported to improve the swallowing function in post-stroke patients. On the other hand, stimulation of the Arnold nerve, the auricular branch of the vagus, triggers the cough reflex (Arnold's ear-cough reflex). Capsaicin, an agonist of Transient Receptor Potential Vanilloid 1 (TRPV1), has been shown to activate the peripheral sensory C-fibers. Stimulation of the sensory branches of the vagus in the laryngotracheal mucosa with capsaicin induces the cough reflex and has been reported to improve the swallowing function in patients with dysphagia. In our previous study, we showed that aural stimulation of the Arnold nerve with 0.025% capsaicin ointment improved the swallowing function, as evaluated by the endoscopic swallowing score, in 26 patients with dysphagia. In the present study, the video images of swallowing recorded in the previous study were re-evaluated using the SMRC scale by an independent otolaryngologist who was blinded to the information about the patients and the endoscopic swallowing score. The SMRC scale is used to evaluate four aspects of the swallowing function: 1) Sensory: the initiation of the swallowing reflex as assessed by the white-out timing; 2) Motion: the ability to hold blue-dyed water in the oral cavity and induce laryngeal elevation; 3) Reflex: glottal closure and the cough reflex induced by touching the epiglottis or arytenoid with the endoscope; 4) Clearance: pharyngeal clearance of the blue-dyed water after swallowing. Accordingly, we demonstrated that a single application of capsaicin ointment to the external auditory canal of patients with dysphagia significantly improved the R, but not the S, M or C scores, and this

  4. Arnebia euchroma ointment can reduce abdominal fat thickness and abdominal circumference of overweight women: A randomized controlled study

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    Mansour Siavash

    2016-01-01

    Full Text Available Background: Obesity is a worldwide health problem which is associated with a lot of complications. One of these comorbidities is the metabolic syndrome that is in correlation with abdominal fat thickness and waist circumference. Various methods were used to reduce abdominal fat thickness such as liposuction. A noninvasive method is the topical agent. In this study, we investigated the effectiveness of Arnebia euchroma (AE ointment on the abdominal fat thickness. Materials and Methods: This study was a double-blind clinical trial which was done at the endocrinology clinic in Khorshid Hospital, Isfahan, Iran, in 2014. After explaining the procedure and obtaining informed consent, the candidates were randomly divided into the case and control groups. The participants of the case and control groups applied AE ointment or placebo for 6 weeks on their abdominal area. Body mass index, waist and buttock circumference, and abdominal fat thickness were measured in both case and control groups at their first visit and then at the next 2, 4, and 6 weeks. We used t-test for comparing parametric variables between groups, paired t-test for changes from baseline to final, and repeated measure ANOVA for changes at different steps. Results: Sixty female candidates participated in this study (thirty in each group. Ten patients left the study and fifty participants finished the trial. At the end of the study, participants had a significant weight loss (2.96 ± 1.6 kg, P < 0.001 that was slightly more in the case group (3.15 ± 1.5 kg vs. 2.75 ± 1.7, P = 0.375. Abdominal circumference also decreased significantly in the participants (11.3 ± 6.7 cm, P < 0.001, but the changes were more significant in the case group (13.9 vs. 6.5 cm, P = 0.004. Similarly, abdominal fat thickness decreased significantly in the participants (2.3 ± 1.1 cm, P < 0.001, although changes were not significantly different between two groups (2.53 vs. 2.04 cm, P = 0.139. Conclusion: Topical

  5. Study on External Application of Eleutherosides Ointment on Shenque (CV 8) for Resisting Sleep Deprivation

    Institute of Scientific and Technical Information of China (English)

    温瑞丽; 王升旭; 李求实; 黄国琪

    2006-01-01

    Objective: To investigate the efficacy of external application of Eleutherosides ointment on Shenque (CV 8) for treating sleep deprivation. Methods: Twenty four healthy young male volunteers at the age of 19-22 years old were randomly allocated to 4 groups (normal, model, treatment and control groups). Sleep was deprived for 48 hours except the normal group. Self-made Eleutherosides compound preparation was applied externally on Shenque (CV 8), to observe its influence on psychology and blood biochemical indices of cortisol and testosterone of the human body in sleep deprivation. Results: After sleep deprivation for 48 hours, an increment in cortisol concentration was lower in the Eleutherosides group (44.482 ± 96.065 nmol/L) than in the control group (146.809 ± 71.075 nmol/L); an increment in the self-evaluated depression scale was also lower in the Eleutherosides group (2.833 ± 16.746) than in the control group (20.417 ± 10.358). There were significant differences (P<0.05). But, there was no significant difference between the treatment group and control group (P>0.05) in the decrement of testosterone concentration and the increment of the anxiety scale. Conclusion: External application of Eleutherosides preparation on Shenque (CV 8) can regulate the stress reaction level and psychological endurance of the human body and produce an effect to resist sleep deprivation.%目的:观察刺五加总甙神阙穴位贴敷疗法的抗睡眠剥夺作用.方法:健康青年男性19~22岁)志愿者24名,完全随机分为4组(正常组、模型组、处理组、对照组),除正常组外剥夺全部睡眠48 h,以自制刺五加总甙复方制剂于神阙穴处贴敷,观察其对睡眠剥夺人体的心理影响以及对皮质醇、睾酮等血液生化指标的影响.结果:48 h睡眠剥夺后,刺五加总甙穴位贴敷皮质醇浓度增高值(44.482±96.065 nmol/L)低于对照组增高值(146.809±71.075 nmol/L),自评抑郁量表增加值(2.833±16.746)

  6. Enhancement of skin permeation of ibuprofen from ointments and gels by sesame oil, sunflower oil and oleic acid

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    Dinda S

    2006-01-01

    Full Text Available Several batches of paraffin ointments were prepared and ibuprofen was incorporated into them. Sesame oil, sunflower oil, and oleic acid in different concentrations were incorporated into different batches. Commercial ibuprofen gel was obtained and divided into several batches and different concentrations of sesame oil, sunflower oil, and oleic acid were incorporated into them. The in vitro drug release characteristics through hairless (88 mm rat skin was carried out by using modified Insertion cell designed in our laboratory. The cell was placed into a borosil beaker containing 50 ml of pH 7.4 phosphate buffer as the diffusion fluid. The beaker was placed over the magnetic stirrer, which was maintained at 37±0.5° to maintain the temperature of diffusion fluid. The released drug content at predetermined time interval was measured using U-V-double beam spectrophotometer at 272 nm. The drug release was raised with increase in oil concentration.

  7. Novel Therapy for Primary Canaliculitis: A Pilot Study of Intracanalicular Ophthalmic Corticosteroid/Antibiotic Combination Ointment Infiltration.

    Science.gov (United States)

    Xu, Jianjiang; Liu, Zuguo; Mashaghi, Alireza; Sun, Xinghuai; Lu, Yi; Li, Yimin; Wu, Dan; Yang, Yujing; Wei, Anji; Zhao, Yujin; Lu, Chun; Hong, Jiaxu

    2015-09-01

    In patients with primary canaliculitis, conservative medical therapy is associated with a high recurrence rate. Surgical treatments carry a great resolution rate but sometimes can result in the lacrimal pump dysfunction and canalicular scarring. The aim of this study is to introduce a minimally invasive approach, intracanalicular ophthalmic corticosteroid/antibiotic combination ointment infiltration (IOI, intracanalicular ointment infiltration), and to report our preliminary results for treating primary canaliculitis. In this retrospective, interventional case series, 68 consecutive patients with newly developed primary canaliculitis at a major tertiary eye center between January 2012 and January 2015. Thirty-six patients received conservative medical treatment alone (group 1; 36 eyes). Twenty-two patients and 10 medically uncontrolled patients from group 1 underwent IOI therapy (group 2; 32 eyes). Ten patients and 26 recurrent patients from group 1 and group 2 underwent surgery (group 3; 36 eyes). Patients were followed-up for at least 8 weeks. Clinical characteristics and outcomes were analyzed and compared. In this study, patients' age, sex, onset location, and durations of disease among 3 groups showed no significant difference. The resolution rate in group 2 was 72.7% (16/22) for new patients and 68.8% (22/32) for gross patients, respectively, both of which are higher than that of group 1 (22.2%, 10/36) but lower than that of group 3 (100%, 36/36). Of group 3, 2 patients received 2 surgical interventions and resolved finally. Microbiological workup was available in 51 patients. The most common isolates were staphylococcus species (27.9%) and streptococcus species (20%). Canalicular laceration developed in 1 patient during the IOI procedure and 1 patient undergoing surgery. Only 2 had postoperative lacrimal pump dysfunction and 1 had canalicular scarring in group 3. The IOI may be an effective and minimally invasive technique for treating primary canaliculitis

  8. A novel wound healing ointment: a formulation of Hypericum perforatum oil and sage and oregano essential oils based on traditional Turkish knowledge.

    Science.gov (United States)

    Süntar, Ipek; Akkol, Esra Küpeli; Keleş, Hikmet; Oktem, Alper; Başer, Kemal Hüsnü Can; Yeşilada, Erdem

    2011-03-08

    Hypericum perforatum L. (Hypericaceae), olive oil (Oleaceae), Origanum Tourn ex L. and Salvia L. species (Lamiaceae) are used against inflammatory disorders and for healing of skin wounds in traditional Turkish medicine. A new ointment formulation was developed to provide more efficient wound healing activity. The content of the formulation was as follows; olive oil extract of flowering aerial parts of Hypericum perforatum L., olive oil, an equivalent mixture of Origanum majorana L. and Origanum minutiflorum Schwrd. et Davis essential oils (Origani aetheroleum), Salvia triloba L. essential oil. The aim of the present study is to assess the wound healing potential of this new formulation by using in vivo and in vitro models as well as histopathological methods. For the evaluation of wound healing potential of this formulation (HPP crème mit Rotöl ointment) in vivo wound healing experimental models were employed on rats and mice and the efficiency was comparatively assessed against a reference ointment Madecassol(®). Tissue sections were also evaluated histopathologically. Furthermore, the wound healing activity of each component was also investigated individually to determine the improvement in the healing capacity of the formulation. The ointments of HPP crème mit Rotöl and Hypericum perforatum L. demonstrated the highest activities on both wound models when compared to reference ointment Madecassol(®), while the other ingredients did not show any remarkable wound healing effect. However, the efficacy of the formulation was remarkably higher than the Hypericum L. ointment alone which was also confirmed by histopathological evaluation. On the other hand, the formulation did not reduce elastase activity in vitro, but inhibited the collagenase activity. HPP crème mit Rotöl also exerted bactericidal and candicidal activities. The experimental studies revealed that HPP crème mit Rotöl formulation displays remarkable wound healing activity. To be acting on the

  9. 复方烧伤膏收敛止痛的疗效观察%Analgesic effect and astringency of Compound burn ointment

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@Background:Burns are injuries caused by attaching factors such as high-temperature,strong acids,and bases etc.Areola and blister or vesticles appear at site in mild cases.Charring,serious toxic heat,consumption of yin fluid,fever,dizzy,thirst,constipation,and oliguria appear in severe cases.Compound burn ointment was developed according to modern traditional Chineses medicine principles and pathological changes of burned skin,which consisted of Sanguisorba root 120 g,Earth worm 120 g,Fibraurea stem 120 g,Dandelion herb 150 g,Dried rehmannia root 150 g,Huanglian 120 g,Yuanhu 150 g,Beeswax 120 g,Borneol 30 g,Oliva 2000 g. Objective:To investigate the analgesic and astringency of compound burn ointment. Unit: Affiliated Central Hospital of Shengyang Medical College.

  10. Evaluating X-ray absorption of nano-bismuth oxide ointment for decreasing risks associated with X-ray exposure among operating room personnel and radiology experts

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    M. Rashidi

    2015-12-01

      Conclusion: It seems that due to higher atomic number and lower toxicity, Bi2O3 nanoparticles have better efficiency in X-ray absorbtion, comparing to the lead. Cream and ointment of bismuth oxide nanoparticles can be used as X-ray absorbant for different professions such as physicians, dentists, radiology experts, and operating room staff and consequently increase health and safety of these employees.

  11. Wound Healing Effect of an Ointment Made From a Mixture of Brassica oleracea var, Punica granatum, and Plantago major L Extracts in Rats

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    Bazafkan

    2014-08-01

    Full Text Available Background In Iranian traditional medicine, Punica granatum, cabbage, and plantago have been used to prompt wound healing. The effects of cabbage, Punica granatum, and Plantago in wound healing have been investigated to some extent, but no experimental study has been performed to assess the impact of an ointment containing all these three substances on wound healing. Objectives The aim of the present study was to evaluate the effect of an ointment prepared from a mixture of cabbage, Punica granatum, and plantago on local wound healing in Wistar rats. Materials and Methods This experimental study was performed on 21 male Wistar rats. Firstly, a full thickness wound was created on rats flank, near the spine by a bistoury blade and forceps. Then they were randomly divided into three groups of seven rats as the control group, a positive control group (the treatment group with phenytoin, and the third one received a treatment with studied ointment. The wounds were evaluated on days three, six, nine, and 12. Results were compared by SPSS software using ANOVA test. Results The average percentage of wound healing in different groups on days 3, 6, 9 and 12 were as follows; 21.3%, 37.87%, 67.39% and 77.17% in control group; 24.98%, 34.21%, 70.74% and 88.55% in positive control group; and 32.35%, 61.27%, 94.53%, and 99.91%, in case group. A significant difference was observed between the control and case groups (P < 0.05. Conclusions Treatment with the studied ointment could promote wound healing.

  12. Clinical application research on the use of the Photon Therapeutic Apparatus combined with Hops extract compound ointment in treatment for breast cancer patients

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    Chen Yunzhu

    2017-01-01

    Full Text Available Objective: To research Carnation-87C photon theraapeutic apparatus combine with compound hops extract ointment in the clinical effect of breast cancer patients after operation with unhealed incision of skin flap necrosis. Method: The experimental group is treated by the conventional therapy and Carnation-87C photon therapeutic apparatus combine with compound hops extract ointment, while the control group is treated by the conventional therapy only, such as regular dressing change. The other treatments for two groups of patients are the same. Through 4 weeks’ treatment, the growth of fresh granulation tissue and healing time were observed between two groups. Results: There were statistically significant differences (P<0.05 in the growth of fresh granulation tissue and healing time between two groups of patients with non-healing skin flap necrosis after the operation. Conclusion: The treatment with the Carnation-87C photon therapeutic apparatus combine with compound hops extract ointment for breast cancer patients after operation with unhealed incision of skin flap necrosis is easy to operate with good curative effect, and it is worth popularizing in clinical application.

  13. BIOPHARMACEUTICAL RESEARCHES IN VITRO ON THE CHOICE OF OPTIMAL COMPOSITION OF PHARMACEUTICAL AID FOR OINTMENT PRODUCTION BASED ON СО2 EXTRACT OF SCHISANDRA CHINENSIS SEEDS

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    Y. A. Morozov

    2014-01-01

    Full Text Available Schisandra chinensis is valuable species of herbal medicines raw materials (fruits, seeds, caruncles, leaves, stem cortex, and roots with root systems which are used for medicines and biologically active supplements production in food and cosmetic industry. However nowadays medicines from Schisandra chinensis are only represented by tincture for internal use on domestic pharmaceutical market. There are data about positive implementation of medicines based on raw materials of Schisandra chinensis as external medicine forms in folk medicine and in literature. The purpose of this work is the development of soft external medicine form – ointment based on СО2 extract of Schisandra chinensis seeds. Biopharmaceutical researches in vitro on the choice of optimal ointment composition by the method of dialysis through semi permeable membrane were conducted for this purpose. Release rate was calculated in relation to base biologically active substances of Schisandra chinensis – lignans (schizandrin and γ-schizandrin which determine its basic pharmacological value. Based on the results of the research conducted it is possible to conclude that the best ointment bases are hydrophilous “classic” poly ethylene oxide and oleogel based on paraffinic oil and aerosil.

  14. 正交试验优选五倍子软膏处方%Optimization of gallnut extract ointment formula by orthogonal test

    Institute of Scientific and Technical Information of China (English)

    王磊; 程岚; 杨跃辉

    2013-01-01

    Objective To optimize the best prescription of gallnut extract ointment. Methods With appearance and stability of ointment as index, orthogonal design experiment was carried out, with beeswax amount, the amount of emulsifier and the major adding method as the variables, the Theological parameters were determined. Results Optimized prescription was A2B3C2 ,which including 2% beeswax,4% span-80,and the way was to put the drug into oil phase. Conclusion The ointment formulation is reasonable, and the preparation has good stability.%目的 优选五倍子软膏剂的最佳处方.方法 以软膏的外观性状、稳定性为考察指标,采用正交设计法进行实验,以蜂蜡用量、乳化剂用量、主要的加入方式为可变因素,并测定流变学参数.结果 优化处方A2B3C2,即蜂蜡2%,span-80 4%,加药方式为药物加入油相.结论 该软膏处方设计合理,制剂稳定性较好.

  15. Contemporary antimicrobial activity of triple antibiotic ointment: a multiphased study of recent clinical isolates in the United States and Australia.

    Science.gov (United States)

    Jones, Ronald N; Li, Qing; Kohut, Bruce; Biedenbach, Douglas J; Bell, Jan; Turnidge, John D

    2006-01-01

    Triple antibiotic ointment (TAO) containing neomycin, polymyxin B, and bacitracin was launched in the 1950s in the United States (USA) as a prescription product and then was used over the counter (OTC) since the 1970s (USA) to prevent superficial wound infections. In Australia, TAO has been restricted to prescription use. This study 1) determined cross-resistance patterns of neomycin compared with other aminoglycosides; 2) determined the level and trend of resistance to TAO and individual components especially versus mupirocin-resistant strains (USA); and 3) established the baseline TAO activity level against pathogens from Australia. A total of 200 strains (> or =50% gentamicin-resistant) from the United States were used for the cross-resistance study including Staphylococcus aureus (110), coagulase-negative staphylococci (CoNS; 50), Pseudomonas aeruginosa (10), Escherichia coli (20), and other Enterobacteriaceae (10) tested against TAO, bacitracin, polymyxin B, neomycin, amikacin, gentamicin, streptomycin, tobramycin, and mupirocin. Fifty gentamicin-resistant isolates from each year (1997-2002) were used to determine the activity of TAO over time. Baseline resistance rates of TAO among 300 Australian isolates (AGARS Program, 2002-2003) were also studied. Reference broth microdilution methods were used in all phases of this study. At a 1:100 dilution of the ointment concentration, TAO inhibited all CoNS, Pseudomonas aeruginosa, and Enterobacteriaceae isolates, and resistance to TAO among Staphylococcus aureus at this concentration was only 5% in the cross-resistance study. Patterns of susceptibility in the United States did not significantly vary from 1997 to 2002. Australian pathogens showed that TAO was 98% active against methicillin-resistant Staphylococcus aureus and 100% for Enterobacteriaceae, methicillin-susceptible S. aureus, CoNS, and P. aeruginosa, the rates equivalent to those observed in the United States. Mupirocin-resistant S. aureus (5%) and Co

  16. 风味普洱茶膏的研制%The development of flavor Pu-erh tea ointment

    Institute of Scientific and Technical Information of China (English)

    龚娜; 肖蓉; 陆文萍; 曹慧; 侯艳

    2015-01-01

    Objective To develop the serial products of Pu-erh tea and one kind of semisolid Pu-erh tea ointment with special flavor and convenient trait. Methods The Yunnan Pu-erh tea was selected as research object, which after extraction, concentration, drying and so on. Based on the single factor test, the affect of white granulated sugar, carboxymethylcellulose sodium (CMC) and lemon essence addition on the sensory scores of the tea ointment was analyzed by response surface methodology. The physical and chemical indexes and microbial indexes of samples were detected and the best processing technology was obtained. Results The optimal extraction condition was that: tea-water ratio was 1:20 g/mL, the additive amount of white granulated sugar, CMC, and lemon essence was 18%, 1.5%, and 2.0%, respectively. The parameter was 2 cm depth on drying process and 18 h of drying time. Conclusion This research will provide theoretical basis and technological foundation for the development of serial products of Pu-erh tea.%目的:开发普洱茶系列产品,研制一种风味独特、携带方便的半固态速溶风味茶膏。方法以云南普洱茶为研究对象,通过浸提、浓缩、干燥等工序进行加工,在单因素试验的基础上,采用响应曲面法分析白砂糖、羧甲基纤维素钠和柠檬香精加入量对茶膏感官分数的影响,测定了样品的理化指标及微生物指标,筛选出最佳制作工艺。结果最佳提取工艺条件为茶水比1:20 g/mL、白砂糖18%、羧甲基纤维素钠1.5%、柠檬香精2.0%;干燥厚度2 cm、干燥时间18 h。结论筛选出的优化组合将为开发普洱茶系列产品提供一定理论依据和技术基础。

  17. Analgesic effect of Chinese herbal formula Hua-Jian-Ba-Du ointment on visceral pain in mice induced by acetic acid.

    Science.gov (United States)

    Ma, Shaojun; Zhang, Ying; Li, Xiaojiang; Zhang, He; Jia, Yingjie

    2015-05-01

    Visceral pain is one of the most important pains caused by cancer or other diseases, and most of the medications may lead to tolerance, addiction, and toxic side effects. Hua-Jian-Ba-Du Ointment (HJBDO), which is a commonly used conjugate based on traditional Chinese medicine theory, has been effective against visceral pain. Here, we verify the efficacy and underlying mechanism of HJBDO in an acetic-acid induced visceral pain model. Mice were subjected to acetic acid with or without HJBDO. Hua-Jian-Ba-Du Ointment at low (7.5 mL/kg•d), moderate (15 mL/kg•d), and high (30 mL/kg•d) dosages was applied on the abdomen, 3 times per day for 3 days. The acetic acid writhing test was used to evaluate antinociception. Interleukin-2 (IL-2) in serum, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and prostaglandin E2 (PGE2) in peritoneal fluid were detected by ELISA. 5-hydroxytryptamine (5-HT), norepinephrine (NE), dopamine (DA), and β-endorphin (β-EP) were examined by high performance liquid chromatography and radioimmunoassay, respectively. N-methyl-D-aspartic acid receptor (NMDAR1) and c-fos expressions in both rostral ventromedial medulla (RVM) and spinal dorsal horn were determined by western blot. Hua-Jian-Ba-Du Ointment at 3 dosage levels produced dose-dependent antinociception and shortened the latent time. Hua-Jian-Ba-Du Ointment at high or moderate dosage inhibited the release of TNF-α, IL-6, and PGE2, as well as increased the release of IL-2. Hua-Jian-Ba-Du Ointment could also increase NE and 5-HT contents and decrease the NE content. No effect of HJBDO at 3 dosages on the DA system was detected. Furthermore, HJBDO could suppress the expressions of NMDAR and c-fos in both RVM and spinal dorsal horn. Our results exhibited the analgesic effect of HJBDO on visceral pain in mice, and this effect might be mediated by the regulation of inflammation and neurotransmitters. © The Author(s) 2015.

  18. An efficency of use phonophoresis with an ointment on the basis of chondroitin sulfate and dimetil sulfoxide at the treatment of patients with arthritis of knee joints

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    Виктор Александрович Вишневский

    2015-06-01

    Full Text Available Osteoarthritis is a frequent disease in people especially of the mean and elderly age.Aim of research: the study of an efficiency of phonophoresis with an ointment on the basis of chondroitin sulfate and dimethyl sulfoxide at treatment of patients with osteoarthritis of knee joints in the outpatient setting.  Material and methods. Research was carried out by the clinical and laboratory examinations of 40 patients with osteoarthritis of knee joints in the outpatient setting.   Patients were distributed between the main and control group depending on an approach to treatment. Indicators before and after treatment in all patients were assessed on 2 scales: the scale of assessment of knee joints (on J.N. Insall et al 1976 - (7 points and 2 Oxford scale for knee joints (on W. Dawson et al, 1998 - (12 point. The level of oxyproline in daily urine was examined in all patients.Results and discussions. The degree of manifestation of pain syndrome, movement amplitude and an everyday motor activity are the parameters of an efficiency of treatment.Author noticed the more apparent efficiency of treatment in patients of the main group who underwent phonophoresis after rubbing an ointment on the basis of chondroitin sulfate in the region of injured knee joint.Disappearance of pains after 10 PhPh with an ointment on the basis of chondroitin sulfate and dimethyl sulfoxide was noticed in 6 (30% patients and diminution of pain intensity in 12 (60% patients. So the general efficiency of treatment is 90% in the main group in relation to 70% of general efficiency of treatment without use this ointment in the control group.Conclusions. 1. Phonophoresis with an ointment on the basis of chondroitin sulfate and dimethyl sulfoxide is a safe and rather effective method of treatment patients with osteoarthritis of knee joints of I-III radiographic stage, an efficiency of treatment is 90%.2. The use of phonophoresis with an ointment containing combination of chondroitin

  19. Topical application of rapamycin ointment ameliorates Dermatophagoides farina body extract-induced atopic dermatitis in NC/Nga mice.

    Science.gov (United States)

    Yang, Fei; Tanaka, Mari; Wataya-Kaneda, Mari; Yang, Lingli; Nakamura, Ayumi; Matsumoto, Shoji; Attia, Mostafa; Murota, Hiroyuki; Katayama, Ichiro

    2014-08-01

    Atopic dermatitis (AD), a chronic inflammatory skin disease characterized by relapsing eczema and intense prurigo, requires effective and safe pharmacological therapy. Recently, rapamycin, an mTOR (mammalian target of rapamycin) inhibitor, has been reported to play a critical role in immune responses and has emerged as an effective immunosuppressive drug. In this study, we assessed whether inhibition of mTOR signalling could suppress dermatitis in mice. Rapamycin was topically applied to inflamed skin in a murine AD model that was developed by repeated topical application of Dermatophagoides farina body (Dfb) extract antigen twice weekly for 7 weeks in NC/Nga mice. The efficacy of topical rapamycin treatment was evaluated immunologically and serologically. Topical application of rapamycin reduced inflammatory cell infiltration in the dermis, alleviated the increase of serum IgE levels and resulted in a significant reduction in clinical skin condition score and marked improvement of histological findings. In addition, increased mTOR phosphorylation in the lesional skin was observed in our murine AD model. Topical application of rapamycin ointment inhibited Dfb antigen-induced dermatitis in NC/Nga mice, promising a new therapy for atopic dermatitis.

  20. A Prospective Randomized Trial of Diltiazem Gel and Glyceryl Trinitrate Ointment on Treatment of Chronic Anal Fissure

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    M Akhondi-Meybodi

    2014-12-01

    Methods: This semi-experimental study consisted of sixty six outpatients (34 females and 32 males with chronic anal fissure, who referred to the gastroenterology clinic. Patients were randomly classified into two groups. Group A received GTN ointment (0.03%, whereas group B was treated with Diltiazem gel (2%. The treatment was administered twice daily for 8 weeks. Healing and side-effects were recorded to be compared after 8 weeks. Results: In group A, the anal fissure was thoroughly healed within 53.3% of patients, moderately healed for 6.7% of patients and not healed in 25.8% of patients. Moreover, side-effects were noted in 15(46.9% patients (P= 0.482. Two (6.2% patients had intolerable headache and discontinued the study, 11 (34.3% patients suffered from headache and 2 patients (6.2% were reported to have orthostatic hypotension. In group B, healing occurred in 21(67.7% out of 31 patients and 1 (3.2% case of headache was noted(P= 0.0001. Conclusion: The present study has demonstrated that topical diltiazem can be preferable to GTN owing to the absence of side-effects.

  1. Wound healing potential of naringin ointment formulation via regulating the expression of inflammatory, apoptotic and growth mediators in experimental rats.

    Science.gov (United States)

    Kandhare, Amit D; Alam, Javed; Patil, Mithun V K; Sinha, Akanksha; Bodhankar, Subhash L

    2016-01-01

    Wound healing is a consequence of a complex process involving inflammatory, proliferative, and remodeling phases. Naringin, a flavanone glycoside, is associated with modulation of various oxido-inflammatory and growth factors. The aim of this study is to evaluate the wound-healing activity of naringin ointment formulation (NOF) on experimental wound models. A soft paraffin-based cream containing 1, 2, and 4% (w/w) naringin was formulated and evaluated for physicochemical characters. Excision wounds and incisions wounds were used to study the topical effect of NOF for 20 d (once a day) on various biochemical, molecular, and histological parameters. NOF (2 and 4%, w/w) treatment showed a significant decrease (p wound area and epithelization period whereas the rate of wound contraction increased significantly (p wound skin were also restored by NOF. NOF exerts wound healing potential via down-regulated expression of inflammatory (NF-κB, TNF-α, and ILs), apoptotic (pol-γ and Bax), and up-regulated growth factor (VEGF and TGF-β) expression, thus modulating collagen-1 expression to induce angiogenesis leading to wound healing.

  2. A round robin exercise in archaeometry: analysis of a blind sample reproducing a seventeenth century pharmaceutical ointment.

    Science.gov (United States)

    Colombini, M P; Modugno, F; Gamberini, M C; Rocchi, M; Baraldi, C; Deviese, T; Stacey, R J; Orlandi, M; Saliu, F; Riedo, C; Chiantore, O; Sciutto, G; Catelli, E; Brambilla, L; Toniolo, L; Miliani, C; Rocchi, P; Bleton, J; Baumer, U; Dietemann, P; Pojana, G; Marras, S

    2011-10-01

    Chemical analysis of ancient residues of pharmaceutical or cosmetic preparations such as balms or ointments is made problematic by the high complexity of these mixtures, composed of organic and inorganic materials. Consequently, a multi-analytical approach and special caution in the interpretation of the results are necessary. In order to contribute to the improvement of analytical strategies for the characterization of complex residues and to reconstruct ancient medical practices, a replica of a pharmaceutical formulation of the seventeenth century was prepared in the laboratory according to a historically documented recipe. In a round robin exercise, a portion of the preparation was analysed as a blind sample by 11 laboratories using various analytical techniques. These included spectroscopic, chromatographic and mass spectrometric methods. None of the laboratories was able to completely reconstruct the complex formulation, but each of them gave partial positive results. The round robin exercise has demonstrated that the application of a multi-analytical approach can permit a complete and reliable reconstruction of the composition. Finally, on the basis of the results, an analytical protocol for the study of residues of ancient medical and pharmaceutical preparations has been outlined.

  3. Successful treatment with 308-nm monochromatic excimer light and subsequent tacrolimus 0.03% ointment in refractory plasma cell cheilitis.

    Science.gov (United States)

    Yoshimura, Kazuhiro; Nakano, Shunji; Tsuruta, Daisuke; Ohata, Chika; Hashimoto, Takashi

    2013-06-01

    Plasma cell cheilitis is a chronic inflammatory disease that presents with erythema, erosions, ulcers and occasional nodules within the mucosa, including the lips. It is histopathologically characterized by dense plasma cell infiltration in the lamina propria of the mucous membranes. Several treatments for plasma cell cheilitis have been reported, including topical steroids, topical antibiotics or topical tacrolimus. However, 308-nm monochromatic excimer light (MEL) has never been reported as a treatment option, while it was reported to be very effective in treating erosive oral lichen planus. We report a 62-year-old man who had chronic plasma cell cheilitis on the lower lip, which was refractory to topical and systemic corticosteroid. The lesion and severe pain were significantly improved by the treatment with nine sessions of 308-nm MEL twice per week with a total dose of 1120 mJ/cm(2). However, the lesion gradually worsened after treatment frequency was reduced to once per month. Subsequent tacrolimus 0.03% ointment cleared the lesion completely in a month and no recurrence was observed a year later. Refractory plasma cell cheilitis and concomitant severe pain quickly responded to 308-nm MEL when administrated twice per week. Because the long interval between each MEL treatment seemed ineffective to improve the lesion, appropriate frequency and adequate total dose of MEL treatment may be necessary for a successful treatment.

  4. To Observe the Clinical Effect of Eczema and Contact Dermatitis by Therapy Compound Polymyxin B Ointment Combination with Compound Flumetasone Ointment%复方多粘菌素B软膏联合复方氟米松软膏治疗湿疹和接触性皮炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    郝慧霞; 莎娜

    2012-01-01

    Objective:To explore and observation the clinical effect of Eczema and Contact Dermatitis by therapy Compound Polymyxin B Ointment combination with Compound Flumetasone Ointment.Methods:Selecting 210 cases who went o to see doctor and diagnosis of Eczema and Contact Dermatitis in our hospital from May of 2010 to May of 2011,these patients were randomly divided into trial group and control group,using Compound Polymyxin B Ointment joint Compound Flumetasone Ointment in trial group and a separate Compound Flumetasone Ointment in control group.Results:The trial group total effective is significantly higher than that in control group (P<0.05),The trial group total effective is 82.28% and 83.33%、 no ineffectiveness;the control group total effective only 54.72% and 60%、 there cases ineffectiveness of Eczema and one case Contact Dermatitis;The time of cure of trial group significantly is lower than the control group (P<0.01).Conclusion:Compound Polymyxin B Ointment combination with Compound Flumetasone Ointment can reduce the time of cure and more significantly better than only Compound Flumetasone Ointment in the clinical effect.%目的:探讨与观察复方多粘菌素B软膏联合复方氟米松软膏治疗湿疹和接触性皮炎的临床疗效.方法:选择2010年5月~2010年11月在我院就诊并诊断为湿疹和接触性皮炎的患者210例,并随机分为联合治疗组和单纯治疗组,联合治疗组采用复方多粘菌素B软膏联合复方氟米松软膏治疗,单纯治疗组采用复方氟米松软膏治疗.结果:湿疹和接触性皮炎的治疗有效率:联合治疗组分别为82.28%和83.33%,无治疗无效患者;单纯治疗组治疗有效率仅为54.72%和60%,且有3例湿疹和1例接触性皮炎患者治疗无效,联合治疗组的治疗有效率显著高于单纯治疗组(P<0.05);联合治疗组临床疗效转折时间显著短于单纯治疗组(P<0.01).结论:复方多粘菌素B软膏联合复方氟米松软膏治疗湿疹和接触性皮

  5. Calcipotriol/betamethasone dipropionate ointment in mild-to-moderate paediatric psoriasis: long-term daily clinical practice data in a prospective cohort.

    Science.gov (United States)

    van Geel, M J; Mul, K; Oostveen, A M; van de Kerkhof, P C M; de Jong, E M G J; Seyger, M M B

    2014-08-01

    Psoriasis in children has a significant negative impact on the quality of life (QoL) and effective treatment can improve this. The two-compound ointment calcipotriol 50 μg g(-1) and betamethasone dipropionate 0·5 mg g(-1) is an effective treatment option for moderate-to-severe psoriasis in adults. To study prospectively the effectiveness and safety of calcipotriol/betamethasone dipropionate ointment in paediatric patients with mild-to-moderate plaque psoriasis in daily clinical practice and to investigate the influence on QoL. Data were obtained from a prospective, longitudinal paediatric psoriasis registry, called Child-CAPTURE. Severity was assessed using the Psoriasis Area and Severity Index (PASI) and body surface area (BSA). The Children's Dermatology Life Quality Index (CDLQI) was used to assess QoL and visual analogue scores (VAS) for pain and itch were collected. For safety data the number of (serious) adverse events was recorded. Seventy-three patients (mean age 10·8 years, range 3-18) were treated for a median time of 35·0 weeks (range 1·0-176·0). At week 12, mean PASI decreased 15·4% (from 5·2 to 4·4), BSA barely changed, and median CDLQI decreased significantly from 5·5 to 4·0. VAS scores for pain and itch declined. At week 24, mean PASI decreased to 4·3 (17·3%). No related serious adverse events were observed. In this daily clinical practice study in paediatric psoriasis, calcipotriol/betamethasone dipropionate ointment initially improved mild-to-moderate psoriasis and then maintained its effect. In addition, it improved QoL, with few adverse events. © 2014 British Association of Dermatologists.

  6. Chinese patent medicine Fei-Liu-Ping ointment as an adjunctive treatment for non-small cell lung cancer: protocol for a systematic review

    Science.gov (United States)

    Zheng, Honggang; He, Shulin; Liu, Rui; Xu, Xinyao; Xu, Tao; Chen, Shuntai; Guo, Qiujun; Gao, Yebo; Hua, Baojin

    2017-01-01

    Introduction Fei-Liu-Ping ointment has been widely applied as adjunctive drug in the treatment of non-small cell lung cancer (NSCLC). However, there has been no systematic review of research findings regarding the efficacy of this treatment. Here, we provide a protocol for assessing the effectiveness and safety of Fei-Liu-Ping ointment in the treatment of NSCLC. Methods and analysis The electronic databases to be searched will include MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, Excerpt Medica Database (EMBASE), China National Knowledge Infrastructure (CNKI), China Scientific Journal Database (VIP), Wanfang Database and Chinese Biomedical Literature Database (CBM). Papers in English or Chinese published from inception to 2016 will be included without any restrictions. We will conduct a meta-analysis of randomised controlled trial if possible. The therapeutic effects according to the standard for treatment of solid tumours by the WHO and the quality of life as evaluated by Karnofsky score and weight will be applied as the primary outcomes. We will also evaluate the data synthesis and risk of bias using Review Manager 5.3 software. Dissemination The results of this review will offer implications for the use of Fei-Liu-Ping ointment as an adjunctive treatment for NSCLC. This knowledge will inform recommendations by surgeons and researchers who are interested in the treatment of NSCLC. The results of this systematic review will be disseminated through presentation at a conference and publication of the data in a peer-reviewed journal. Trial registration number PROSPERO CRD42016036911. PMID:28093444

  7. Cost effectiveness of adding clostridial collagenase ointment to selective debridement in individuals with stage IV pressure ulcers.

    Science.gov (United States)

    Carter, Marissa J; Gilligan, Adrienne M; Waycaster, Curtis R; Schaum, Kathleen; Fife, Caroline E

    2017-03-01

    The purpose of this study was to determine the cost effectiveness (from a payer's perspective) of adding clostridial collagenase ointment (CCO) to selective debridement compared with selective debridement alone (non-CCO) in the treatment of stage IV pressure ulcers among patients identified from the US Wound Registry. A 3-state Markov model was developed to determine costs and outcomes between the CCO and non-CCO groups over a 2-year time horizon. Outcome data were derived from a retrospective clinical study and included the proportion of pressure ulcers that were closed (epithelialized) over 2 years and the time to wound closure. Transition probabilities for the Markov states were estimated from the clinical study. In the Markov model, the clinical outcome is presented as ulcer-free weeks, which represents the time the wound is in the epithelialized state. Costs for each 4-week cycle were based on frequencies of clinic visits, debridement, and CCO application rates from the clinical study. The final model outputs were cumulative costs (in US dollars), clinical outcome (ulcer-free weeks), and incremental cost-effectiveness ratio (ICER) at 2 years. Compared with the non-CCO group, the CCO group incurred lower costs ($11,151 vs $17,596) and greater benefits (33.9 vs 16.8 ulcer-free weeks), resulting in an economically dominant ICER of -$375 per ulcer. Thus, for each additional ulcer-free week that can be gained, there is a concurrent cost savings of $375 if CCO treatment is selected. Over a 2-year period, an additional 17.2 ulcer-free weeks can be gained with concurrent cost savings of $6,445 for each patient. In this Markov model based on real-world data from the US Wound Registry, the addition of CCO to selective debridement in the treatment of pressure ulcers was economically dominant over selective debridement alone, resulting in greater benefit to the patient at lower cost.

  8. Ultrastructural Analysis of the Foreskin in Patients With True Phimosis Treated or Not Treated With Topical Betamethasone and Hyaluronidase Ointment.

    Science.gov (United States)

    Favorito, Luciano Alves; Gallo, Carla B M; Costa, Waldemar S; Sampaio, Francisco J B

    2016-12-01

    To evaluate, by using scanning electron microscopy (SEM), the possible alterations of the foreskin connective tissue in patients with true phimosis submitted to topical treatment with betamethasone and hyaluronidase ointment. We studied 15 patients (mean 5.3 years old) submitted or not to topical application of betamethasone 0.2% and hyaluronidase cream. For qualitative analysis of the connective tissue, we studied 5 samples from each foreskin, with 2 mm length. The samples were submitted to fixation for SEM by immersing tissue fragments in a modified Karnovsky solution for 48 hours at 4°C. The obtained acellular preparations were then processed for high-vacuum SEM, and observations were performed on a LEO 435 (Zeiss, Oberkochen, Germany) scanning electron microscope with an acceleration voltage of 15 to 20 kV. Parents of 7 children did not agree with the clinical treatment and opted for circumcision directly. These patients served as the control group (nontreated). Eight patients submitted to topical treatment could not expose the glans and were referred for circumcision. In SEM, with a magnification of 5000×, we observed important differences in the organization of the collagen and elastic system fibers when comparing treated and nontreated patients with betamethasone and hyaluronidase. Treated patients presented a different organization of collagen with a clear decrease in the elastic system fibers. The treatment of phimosis with betamethasone + hyaluronidase showed changes in the structure of the foreskin with a decrease of elastic system fibers, which is characteristic of the healing processes. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Wound-Healing potential of Sebastiania hispida (Mart. Pax (Euphorbiaceae ointment compared to low power laser in rats

    Directory of Open Access Journals (Sweden)

    E. S. Rizzi

    Full Text Available Abstract Impaired wound healing represents a serious complication in some pathologies and the use of plant extracts has proved to improve tissue repair. The objectives of this study were to evaluate the healing potential of the ointment of Sebastiana hispida compared with Aluminum-Gallium Indium-Phosphide Laser (InGaAlP in surgically induced wounds in rats and to perform the phytochemical analysis. The phytochemical analysis was performed in the classic way and also by HPLC. A controlled study was developed with 80 rats (200-250 g in which a linear excision was performed in the dorsal region after shaving, measuring 2 cm × 1 cm (epidermis and dermis exposing the muscle fascia. The rats were randomly divided into four groups of twenty animals each. The experimental groups (n = 5 were G1 (Saline; G2 (crude methanol plant extract 2% + Carbopol Gel 98%; G3 (crude methanol plant extract 2% + lanolin/vaseline and G4 (laser. The incision healing processes were monitored during 3, 7, 14 and until 21 days after excision. The histologic parameters evaluated were Collagen fiber types, microscopic examination and neovascularization. There was a significant increase in the deposition of collagen fibers, as evidenced by a better organized epithelial tissue, keratinized and showing greater proliferation of new blood vessels in the inflammatory phase in the group treated with both the extract and laser. The results were correlated to the phenolic derivatives found after qualitative and quantitative analysis. These compounds were considered responsible for the healing process. The topical treatment with S. hispida leaves, in the two different formulations, was more effective than the application of the laser (Ingan ALP 660 nm in the model used.

  10. Effect of New Pulian Ointment (新普连膏) in Treating Psoriasis of Blood-Heat Syndrome:A Randomized Controlled Trial

    Institute of Scientific and Technical Information of China (English)

    周宁; 白彦萍; 蔓小红; 张云璧; 孔宇虹; 鞠海; 常明

    2009-01-01

    Objective:To objectively assess the clinical efficacy and safety of a new Pulian Ointment(新普连膏,NPLO) in treating psoriasis of blood-heat syndrome of Chinese medicine.Methods:A total of 108 patients with psoriasis of blood-heat syndrome were equally assigned,using a randomizing digital table,to the test group treated externally with NPLO and the control group treated with placebo;the medication was done using a single-blinded method twice a day.Meanwhile,all patients received by oral intake a conventional...

  11. Double-Blind, Placebo-Controlled, Randomized Study Comparing 0.0003% Calcitriol with 0.1% Tacrolimus Ointments for the Treatment of Endemic Pityriasis Alba

    Directory of Open Access Journals (Sweden)

    Berenice Moreno-Cruz

    2012-01-01

    Full Text Available Background. Pityriasis alba (PA is a frequent cause of consultation in tropical areas due to its chronic course, frequent relapses, and notorious hypopigmented lesions in pediatric dark skin populations. Currently, no treatment is widely accepted. Objective. To assess the efficacy of 0.0003% calcitriol and 0.1% tacrolimus ointments compared with placebo in the treatment of endemic PA. Methods. Twenty-eight children aged 3–17 years with 56 symmetrical lesions and phototype IV-V, were randomly assigned to receive the treatments on target lesions on the face. Improvement was evaluated at baseline and 8 weeks later clinically and by digital quantification of the affected area, colorimetry, and transepidermal water loss (TEWL. Results. Tacrolimus and calcitriol ointments induced a mean improvement of 68%, compared to 44% of placebo. We found an elevated TEWL in PA lesions. In the treated plaques, the reduction of the affected area was associated with improvement of pigmentation and TEWL. Conclusions. Calcitriol and tacrolimus induced similar repigmentation in endemic PA lesions. Melanogenic, anti-inflammatory, and barrier defect restoration properties of these drugs may explain these findings.

  12. Successful Treatment of Keloid With Fractionated Carbon Dioxide (CO2) Laser and Laser-Assisted Drug Delivery of Triamcinolone Acetonide Ointment in an African-American Man.

    Science.gov (United States)

    Kraeva, Ekaterina; Ho, Derek; Jagdeo, Jared

    2017-09-01

    Keloids are fibrous growths that occur as a result of abnormal response to dermal injury. Keloids are cosmetically disfiguring and may impair function, often resulting in decreased patient quality-of-life. Treatment of keloids remains challenging, and rate of recurrence is high. We present a case of a 39-year-old African-American man (Fitzpatrick VI) with a 10-year history of keloid, who was successfully treated with eight sessions of fractionated carbon dioxide (CO2) laser immediately followed by laser-assisted drug delivery (LADD) of topical triamcinolone acetonide (TAC) ointment and review the medical literature on fractionated CO2 laser treatment of keloids. To the best of our knowledge, this is the first report of successful treatment of a keloid using combination therapy of fractionated CO2 laser and LADD with topical TAC ointment in an African-American man (Fitzpatrick VI) with excellent cosmetic results sustained at 22 months post-treatment. We believe that this combination treatment modality may be safe and efficacious for keloids in skin of color (Fitzpatrick IV-VI) and other patients. This case highlights the ability of laser surgeons to safely use fractionated CO2 lasers in patients of all skin colors. J Drugs Dermatol. 2017;16(9):925-927..

  13. Exploratory, Phase II Controlled Trial of Shiunko Ointment Local Application Twice a Day for 4 Weeks in Ethiopian Patients with Localized Cutaneous Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Kesara Na-Bangchang

    2016-01-01

    Full Text Available The clinical efficacy and safety of Shiunko ointment (phase II clinical trial was investigated in 40 Ethiopian patients with cutaneous leishmaniasis. Patients were randomized to receive treatment with Shiunko ointment or placebo (n=20, each, applied on the lesion twice a day for 4 weeks. Clinicoparasitological assessments were performed before treatment, weekly for 4 weeks, and then 4, 8, and 12 weeks after the end of treatment. A marked reduction in lesion size was observed on week 16 of treatment in the Shiunko compared with placebo group (69% and 22% reduction, resp.. The overall rate of lesion reduction during the four weeks of treatment was significantly faster in the Shiunko group. Shiunko provided significant effect on wound closure in patients with ulcerated lesion. The clinical efficacy and tolerability of Shiunko were comparable to placebo with regard to its clinicoparasitological response (cure rate and parasitological clearance. Results of this preliminary study may suggest that Shiunko could be useful as adjuvant or as complementary treatment, not as alternatives to current treatment. Its attractive action includes fast lesion healing with a significantly smaller lesion at week 16 of treatment compared with placebo. In addition, its action was promoted in ulcerative lesions.

  14. 复方中药膏剂治疗临床型奶牛乳房炎效果研究%Effect of Herbal Compound Ointment on Treatment of Clinical Cows Mastitis

    Institute of Scientific and Technical Information of China (English)

    欧德渊; 黄璐; 王彬; 禾彩红; 施云刚

    2012-01-01

    Objective: We used herbal ointment instead of antibiotics to produce antibiotic -free milk. Methods: Traditional Chinese medicine was crushed into paste and made into the ointment, which then directly applied on the breasts of suffering cattle. Direct nipple administration was conducted in antibiotic treatment group. Results: ( 1 ) Ichthyol could be used as oil and water miscible emulsifier; (2) The efficacy of herbal ointment was significandy higher than the antibiotic group, and there was no recurrence during the observation period. Conclusion: The herbal ointment can be a useful treatment of cow mastitis, and has broad prospects.%目的:使用中药软膏剂替代抗生素,生产无抗奶。方法:中药粉碎成浆,制成软膏剂,直接涂抹于患牛乳房上,抗生素治疗组直接乳头给药。结果:(1)鱼石脂可作为油水互溶的乳化剂;(2)中药软膏剂疗效显著优于抗生素组,在观察期中无复发。结论:中药软膏剂能很好地治疗奶牛乳房炎,具有广阔的应用前景。

  15. Efficacy of Topical Alpha Ointment (Containing Natural Henna Compared to Topical Hydrocortisone (1% in the Healing of Radiation-Induced Dermatitis in Patients with Breast Cancer: A Randomized Controlled Clinical Trial

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    Mansour Ansari

    2013-12-01

    Full Text Available Background: This two-arm, randomized clinical study aimed to compare efficacy between topical Alpha ointment and topical hydrocortisone cream (1% in the healing of radiation-induced dermatitis in breast cancer patients. Methods: The inclusion criteria comprised newly pathologically proven, locally advanced breast cancer (treated with modified radical mastectomy followed by sequential adjuvant treatments, including chest wall radiotherapy [45-50.4 Gy] and grade 2 and/or 3 chest wall dermatitis. The exclusion criteria were comprised of any underlying disease or medications interfering with the wound healing process, previous history of chest wall radiotherapy, and concurrent use of chemotherapy. Sixty eligible patients were randomly assigned to use either topical Alpha ointment (study arm, n=30 or topical hydrocortisone cream (1% (control arm, n=30 immediately after receiving a total dose of 45-50 Gy chest wall radiotherapy. Results: The mean radiation dose was 49.1 Gy in the control arm and 48.8 Gy in the study arm. The mean dermatitis area was 13.54 cm2 in the control arm and 17.02 cm2 in the study arm. Topical Alpha ointment was more effective on the healing of radiation-induced dermatitis than was topical hydrocortisone cream (1% (P=0.001. This effect was significant in the second week (P=0.007. In addition, Alpha ointment decreased the patients’ complaints such as pain (P<0.001, pruritus (P=0.009, and discharge (P=0.010 effectively and meaningfully. Conclusion: Topical Alpha ointment was more effective on the healing of radiation-induced dermatitis than was topical hydrocortisone cream (1% in our patients with breast cancer. Trial Registration Numbers: IRCT201206099979N1 ACTRN12612000837820

  16. HPLC法测定薄荷苯酚软膏中苯酚的含量%Determination of phenol in menthol-phenol ointment by HPLC

    Institute of Scientific and Technical Information of China (English)

    蔡乐; 白林; 徐风华; 任韡; 王欢欢

    2014-01-01

    Objective:To establish the HPLC method for determination of phenol in menthol-phenol ointment. Methods:The phenol in menthol-phenol ointment was extracted by ultrasonic method, and the content of phenol was determined by HPLC method. The analysis was carried out on a column of Diamonsil C18 (250 mm × 4.6 mm, 5μm) with mobile phase consisting of methanol-water (60∶40), the lfow rate was 1.0 mL·min-1. The detection wavelength was set at 271 nm, and the column temperature was 45℃. Results:Phenol showed a good linear relationship in the range of 9-360μg·mL-1 (r=0.999 9). The average recovery was 100.2%with RSD of 0.68%(n=6). Conclusion: The method is simple, accurate and repeatable, which is suitable for the content determination of phenol in menthol-phenol ointment.%目的:建立HPLC法测定薄荷苯酚软膏中苯酚的含量。方法:采用超声提取方法处理薄荷苯酚软膏,用HPLC法进行含量测定。色谱柱:Diamonsil C18柱(250 mm ×4.6 mm,5μm),流动相:甲醇-水(60∶40),流速:1.0 mL·min-1,检测波长:271 nm,柱温:45℃。结果:苯酚在9~360μg·mL-1范围内线性关系良好(r=0.9999);样品平均回收率为100.2%,RSD为0.68%(n=6)。结论:本方法简便、准确、重复性好,可用于薄荷苯酚软膏中苯酚的含量测定。

  17. Influence of a new wound-healing ointment on morphogenesis of full-thickness excision wounds in healthy rats and rats with diabetic state

    Directory of Open Access Journals (Sweden)

    Derymedvid L.V.

    2014-06-01

    Full Text Available Background. Impaired wound healing is a complication of diabetic state and is a serious medical and social problem. It occurs as a consequence of disequilibrium in reactive oxygen species (ROS and antioxidant defense system. Therefore local treatment with antioxidants is promising in this type of pathology. Objective. The aim of this study was morphological evaluation of the influence of a new wound-healing ointment containing licorice extract, coenzyme Q10 and dihydroquercetin on the model of natural and delayed wounds in rats. Methods. For morphological evaluation on Day 6 and 12 we took specimens of tissues with wound and surrounding intact skin. Prepared histological slides and stained with haematoxylin, eosin and picrofuchsin by Van Gieson. Results. It was noted that process of excision wound healing in rats with diabetic state had prolonged inflammatory phase. Thus, on the Day 6 of observation during wound-healing in a physiologically healthy rats fibrinoid-necrotic layer in the surface layers of the defect was quite dense, with a limited number of leukocyte cells. Young newly formed granulation tissue in the bottom areas also purified from neutrophil leukocytes. Inflammatory reaction in the boundary to the defect areas of skin was extinguished. And in rats with diabetic state same fibrinoid-necrotic layer was markedly attenuated, full of polymorphonuclear leukocytes, granulation cells also contained many white blood cells in the boundary areas of healthy skin observed exocytosis of epithelial layer, a marked inflammation and destruction of the dermis. All this led to decrease in speed of development and maturation of granulation tissue on the 12th day of observation in these animals compared with physiologically healthy rats. Conclusion. The results showed that the studied ointment optimizes reparative tissue regeneration in the healing of skin excision wounds in rats with pre-modeled diabetogenic state. Nature of reparative processes in

  18. EXPERIMENTAL STUDY OF THE EFFECT OF MOIST EXPOSED BURN THERAPY/MOIST EXPOSED BURN OINTMENT ON MAINTAINING A PHYSIOLOGICAL MOIST ENVIRONMENT IN BURN WOUND

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective: To verify the moisture maintaining effect of moist exposed burn ointment (MEBO) in treating burn wound. Methods: Rabbit model with II degree burn wound was used in this study. Observations were conducted at 0 (before burn), 0.5, 6, 24, 48, 72, and 168 hours postburn. The data of wound water evaporation, wound appearance and pathological changes of the wounds were compared with that of the burn wounds treated with Vaseline or conventional dry exposed therapy. Results: It was found that wounds treated with MEBO had water evaporation close to that of normal skin and was significantly less than that of the wounds treated with dry exposed therapy (P<0.01) MEBO did not obstruct water evaporation from wound as Vaseline did(P<0.01).Wounds treated with MEBO had good permeability and adequate drainage. Conclusion: MEBO provided the wounds with a physiological moist environment

  19. Shengjiyuhong ointment inhibits hypertrophic scar formation%生肌玉红膏对增生性瘢痕的抑制作用

    Institute of Scientific and Technical Information of China (English)

    孙桂芳; 张晓芬; 李红昌; 潘丽芸; 陈亚峰; 徐可; 奉典旭

    2016-01-01

    BACKGROUND:Shengjiyuhong ointment has been reported to inhibit hypertrophic scarring. OBJECTIVE:To verify the effects of Shengjiyuhong ointment on hypertrophic scarring of in a rabbit ear model. METHODS:Each ear of thirty-six Japanese rabbits was used to make four 1-cm-diameter circular ful-thickness skin wounds with the entire perichondrium removed. Final y, 288 wounds were made and randomly divided into 6 groups:model, negative control (no drugs were administered), low-, moderate-, high-crude herbal dose drugs (Shengjiyuhong ointment was administered topical y at concentrations of 8.39%, 25.18%, and 75.54%), and positive control (recombinant bovine basic fibroblast growth factor was administered topical y). Shengjiyuhong ointment was administered twice daily til wound healing. The wounds were evaluated by the Vancouver scar scale (VSS). Scar elevation index (SEI) of scar specimens was calculated under a microscope at 40× magnification. mRNA expression levels of type I and III col agen, connective tissue growth factor, fibronectin, andα-smooth muscle actin (α-SMA) were determined by fluorescent quantitative PCR. Protein expression levels of type I and III col agen andα-SMA were detected by western blot assay.α-SMA immunoreactivity was determined by immunofluorescent staining. RESULTS AND CONCLUSION:VSS scores and SEI were significantly increased in each group at 30 days (P<0.05). VSS scores and SEI were significantly decreased in the moderate-and high-crude herbal dose drug groups and positive control groups compared with the model, negative control, and low-crude herbal dose drug groups (P<0.05 or P<0.01). mRNA expression levels of type I and III col agen, connective tissue growth factor and fibronectin, and protein expression levels of type I and III col agen andα-SMA were significantly inhibited after moderate-crude herbal dose Shengjiyuhong ointment and positive drug treatment (P<0.01). These findings suggest that Shengjiyuhong ointment can reduce

  20. Anti-inflammatory and antipruritic effects of Chushizhiyang ointment%除湿止痒软膏抗炎及止痒作用研究

    Institute of Scientific and Technical Information of China (English)

    曾怡; 史梦琪; 杨欢; 何萍; 王有为; 杜俊蓉

    2015-01-01

    目的:探讨除湿止痒软膏的抗炎及止痒作用。方法用2,4-二硝基氟苯(DNFB)腹部致敏和背部反复激发建立 BALB/c 小鼠特应性皮炎模型。实验动物分为正常对照组(未致敏也未治疗)、模型对照组(致敏但未治疗)、氢化可的松乳膏组(致敏+氢化可的松)、除湿止痒软膏组(致敏+除湿止痒软膏)。连续用药14 d,末次给药12 h 后取背部皮肤,测定皮肤厚度及质量,进行 HE 染色和甲苯胺蓝染色,ELISA 法检测皮损组织中干扰素(IFN)γ、肿瘤坏死因子(TNF)α、白细胞介素(IL)-4、IL-5含量。利用磷酸组胺诱发 Hartley 豚鼠局部皮肤瘙痒模型,观察除湿止痒软膏对豚鼠致痒阈的影响。结果用药后第15天,与模型对照组相比,氢化可的松乳膏和除湿止痒软膏均可明显减少小鼠的背部皮肤厚度和质量(P <0.01),减少淋巴细胞和肥大细胞浸润(P <0.01)以及降低皮损组织中 IFN-γ、TNF-α、IL-4及 IL-5水平(P <0.05或 P <0.01)。与正常对照组相比,氢化可的松乳膏组小鼠背部皮肤厚度和质量减小(P <0.01),除湿止痒软膏组无明显变化。此外,除湿止痒软膏也可显著提高豚鼠耐受磷酸组胺的致痒阈(P <0.01)。结论除湿止痒软膏可明显抑制 DNFB 引起的小鼠特应性皮炎,其抗炎机制可能与恢复体内 Th1/Th2型细胞因子平衡有关。除湿止痒软膏可明显减轻磷酸组胺所致豚鼠皮肤瘙痒反应。%Objective To explore the anti-inflammatory and antipruritic effects of Chushizhiyang ointment in a mouse model. Methods A total of 40 male 8-week-old BALB/c mice were included in this study, and randomly and equally divided into 4 groups. A mouse model of atopic dermatitis (AD)was established in three groups of mice by repeated application of 2,4-dinitroflurobenzene (DNFB)to shaved abdominal skin for sensitization and to shaved dorsal skin for

  1. Efficacy of compound clobetasol propionate ointment in the treatment of chronic eczema in 53 cases%复方丙酸氯倍他索软膏治疗慢性湿疹53例疗效观察

    Institute of Scientific and Technical Information of China (English)

    吴伟庆; 张婕

    2016-01-01

    目的:探讨复方丙酸氯倍他索软膏治疗慢性湿疹的疗效及安全性。方法:收治慢性湿疹患者107例,随机分为治疗组54例和对照组53例,对照组采用醋酸曲安奈德尿素软膏治疗,治疗组采用复方丙酸氯倍他索软膏治疗,比较两组治疗效果。结果:治疗组痊愈率和有效率明显高于对照组,复发率明显低于对照组(P<0.05)。结论:复方丙酸氯倍他索软膏治疗慢性湿疹疗效显著,不良反应少。%Objective:To explore the efficacy and safety of compound clobetasol propionate ointment in the treatment of chronic eczema.Methods:105 patients with chronic eczema were selected.They were randomly divided into the treatment group with 53 cases and the control group with 52 cases.The control group was treated with triamcinolone acetonide acetate urea ointment.The treatment group was treated with compound clobetasol propionate ointment.We compared the therapeutic effect of two groups. Results:In the treatment group,the cure rate and effective rate were significantly higher than the control group,and the recurrence rate was significantly lower than that of the control group(P<0.05).Conclusion:The efficacy of compound clobetasol propionate ointment in the treatment of chronic eczema was significant,and adverse reactions were less.

  2. 扶他林软膏外用治疗轻中度腕管综合征疗效观察%Curative effect observation of voltaren ointment in the treatment of mild to moderate carpal tube syndrome

    Institute of Scientific and Technical Information of China (English)

    宋正锋

    2014-01-01

    目的:对比观察扶他林软膏外用治疗腕管综合征的疗效。方法:把68例轻中度腕管综合征患者随机分成扶他林软膏外用组和扶他林片剂口服组。两组均减少双手和手腕的活动,并口服维生素B1和弥可保30天。结果:两组于治疗后7天和30天对比分析,扶他林软膏外用组的疗效明显高于对照组,差异有统计学意义(P<0.05)。结论:扶他林软膏外用与口服扶他林片剂对比具有疗效好、见效快、不良反应少的特点。%Objective:To observe the curative effect of voltaren ointment in the treatment of carpal tunnel syndrome.Methods:68 cases with mild to moderate carpal tunnel syndrome were randomly divided into the voltaren ointment treatment group and the votalin pill oral treatment group according to the inclusion criteria.The two groups were reduced both hands and wrists activity,and oral vitamin B1 and mecobalamin for 30 days.Results:We analyzed the results between the two groups after the treatment for 7 days and 30 days.The curative effect of the voltaren ointment group was significantly higher than that of the control group,and there was statistically significant difference(P<0.05).Conclusion:The voltaren ointment has good curative effect,quick effect,fewer side effects and other characteristics than the oral voltaren tablets.

  3. Tolerability and effects on quality of life of liposomal nasal spray treatment compared to nasal ointment containing dexpanthenol or isotonic NaCl spray in patients with rhinitis sicca

    OpenAIRE

    2013-01-01

    This study aimed to investigate symptom reduction via the liposomal nasal spray LipoNasal (LN) in patients with rhinitis sicca. Tolerability and the impact on quality of life were also examined. The same parameters were established in parallel for treatment approaches with Bepanthen (BP) nasal ointment containing dexpanthenol and the Rhinomer (RH) nasal spray containing NaCl. This prospective, controlled, open-label observation study was a multicenter trial. 92 patients with rhinitis sicca we...

  4. 白脉软膏治疗紧张型头痛疗效观察%The effect of Baimai ointment in treating tension headache

    Institute of Scientific and Technical Information of China (English)

    白杨; 夏璐

    2016-01-01

    Objective: To observe the effect of Bai Mai ointment in the treatment of tension headache. Method: 40 patients with tension headache were randomly divided into two groups, 20 cases in the control group were treated with acupuncture, massage and pain relieve, the other 20 cases in the treatment group were treated with acupuncture, and massage and pain relieve, and additionally treated with Baimai ointment on the pain points of the peripheral muscle. VAS score and blood flow velocity were compared before and after treatment in two groups. Results: There were no significant difference in VAS score before treatment in the control group and treatment group. However, the VAS score in treatment group was significantly lower than that in control group after treatment,P<0.05; There were no significant difference in the blood flow velocity of middle cerebral artery in both group before treatment, but the blood flow velocity of middle cerebral artery in the treatment group was significantly lower than that of the control group in the 3rd week of the treatment (P<0.05), indicating that the treatment group was superior to that of control group in blood flow velocity of middle cerebral artery improvement. Conclusion: Bai Mai ointment had good effective in the treatment of tension headache and there was no side effect.%目的:观察白脉软膏治疗紧张型头痛的临床疗效。方法:将我科收治40例紧张型头痛患者随机分为两组,对照组和治疗组,各20例,常规予针刺、按摩、止痛对症治疗,治疗组除常规予针刺、按摩、止痛对症治疗外,使用白脉软膏对颅周肌筋膜压痛点按摩治疗。比较两组治疗前后VAS评分及血流速改变。结果:各组VAS评分于治疗前无统计学差异,治疗后,治疗组VAS评分显著低于对照组,P<0.05;各组大脑中动脉收缩期血流速度的测定在治疗前无统计学差异,治疗第3周后,治疗组大脑中动脉收缩期血流速度

  5. Identification and Characterization of Novel Matrix-Derived Bioactive Peptides: A Role for Collagenase from Santyl® Ointment in Post-Debridement Wound Healing?

    Science.gov (United States)

    Sheets, Anthony R; Demidova-Rice, Tatiana N; Shi, Lei; Ronfard, Vincent; Grover, Komel V; Herman, Ira M

    2016-01-01

    Debridement, the removal of diseased, nonviable tissue, is critical for clinicians to readily assess wound status and prepare the wound bed for advanced therapeutics or downstream active healing. Removing necrotic slough and eschar through surgical or mechanical methods is less specific and may be painful for patients. Enzymatic debridement agents, such as Clostridial collagenase, selectively and painlessly degrade devitalized tissue. In addition to its debriding activities, highly-purified Clostridial collagenase actively promotes healing, and our past studies reveal that extracellular matrices digested with this enzyme yield peptides that activate cellular migratory, proliferative and angiogenic responses to injury in vitro, and promote wound closure in vivo. Intriguingly, while collagenase Santyl® ointment, a sterile preparation containing Clostridial collagenases and other non-specific proteases, is a well-accepted enzymatic debridement agent, its role as an active healing entity has never been established. Based on our previous studies of pure Clostridial collagenase, we now ask whether the mixture of enzymes contained within Santyl® produces matrix-derived peptides that promote cellular injury responses in vitro and stimulate wound closure in vivo. Here, we identify novel collagen fragments, along with collagen-associated peptides derived from thrombospondin-1, multimerin-1, fibronectin, TGFβ-induced protein ig-h3 and tenascin-C, generated from Santyl® collagenase-digested human dermal capillary endothelial and fibroblastic matrices, which increase cell proliferation and angiogenic remodeling in vitro by 50-100% over controls. Using an established model of impaired healing, we further demonstrate a specific dose of collagenase from Santyl® ointment, as well as the newly-identified and chemically-synthesized ECM-derived peptides significantly increase wound re-epithelialization by 60-100% over saline-treated controls. These results not only confirm and

  6. Determination of Berberine Hydrochloride in Shenshe Ointments by HPLC%HPLC法测定参蛇软膏中盐酸小檗碱的含量

    Institute of Scientific and Technical Information of China (English)

    缪珊; 栗艳; 李捷; 毕琳琳; 张雅; 石小鹏

    2014-01-01

    目的:建立参蛇软膏中盐酸小糪碱的含量测定方法。方法:采用高效液相色谱法测定参蛇软膏中盐酸小糪碱的含量,Kromasil C18色谱柱(250 mm ×4.6 mm,5μm);乙腈-0.1%磷酸(41∶59)(每100 ml加入十二烷基磺酸钠0.02 g)为流动相;流速:1.0 ml·min-1;检测波长:320 nm;柱温:室温;进样量:20μl。结果:盐酸小檗碱与其他组分分离良好,在0.0592~0.2960 g·L-1范围内线性关系良好(r=0.9994);平均加样回收率为99.80%,RSD=0.24%(n=6)。结论:该方法简单、专属性强、重复性好,可用于参蛇软膏的含量测定。%Objective:To establish the determination method for berberine hydrochloride in Shenshe ointments. Methods: The quantitative analysis of berberine hydrochloride in Shenshe osintments was carried out by HPLC with a Kromsal C18 chromatographic column (250 mm × 4. 6 mm, 5 μm), the mobile phase was acetonitrile-0. 1% phosphoric acid (49∶51) (adding 0. 2g sodium dode-cylsulphate into 100 ml solution) with the flow rate of 1. 0 ml·min-1 and the detection wavelength of 320nm, the temperature of col-umn was room temperature, and the injection volume was 20 μl. Results: The linear range was 0. 059 2-0. 296 0 g·L-1 with good correlation(r=0. 999 4). The average recovery was 99. 80% and RSD was 0. 24%(n=6). Conclusion: The established method is accurate, specific and reproducible, and suitable for the determination of berberine hydrochloride in Shenshe ointments.

  7. 婴幼儿湿疹中药配方特制膏临床应用的疗效观察%Observation on the efficacy of clinical application of a special infant-eczema ointment consisted of herbs

    Institute of Scientific and Technical Information of China (English)

    肖春光; 尹爱良; 刘艳丽

    2013-01-01

      目的探讨中药配方特制膏治疗婴幼儿湿疹的临床价值。方法将门诊就诊的128例婴幼儿湿疹患儿随机分成治疗组和对照组,治疗组63例应用婴幼儿湿疹中药配方特制膏外用,对照组65例应用醋酸氟氢松乳膏外用,分析比较两组婴幼儿湿疹患儿的治愈率和总有效率。结果治疗组治愈率和总有效率均优于对照组,组间差异有统计学意义(P<0.01)。结论应用婴幼儿湿疹中药配方特制膏治疗婴幼儿湿疹合理、方便、有效。%Objective To investigate the efficacy of clinical application of a special infant-eczema ointment consisted of herbs to infants and children with eczema and to explore the clinical application value of this ointment. Methods 128 cases of infants and children with eczema who visited the clinic were randomly divided into treatment group and control group. 63 cases of patient in the experimental group, this special ointment was used externally, and 65 cases of patient in the control group received external treatment with fluocinonide ointment. The differences of the cure rate(CR) and the overall effective rate(OER) between these two groups were analyzed and compared using statistical analysis. Results There was statistical significance in the rate of cure and overall efficacy between these two groups(P<0.01). Conclusion The clinical application of this special infant-eczema ointment consisted of herbs to infants and children with eczema displays properties of reasonability, effectiveness and convenience.

  8. Observation on short-term outcomes of calcipotriol ointment combined compound clobetasol propionate ointment in psoriasis treatment%卡泊三醇联合复方丙酸氯倍他索软膏治疗银屑病的近期疗效观察

    Institute of Scientific and Technical Information of China (English)

    杨桂兰; 王剑峰; 王佳媚; 宁舒鹏; 白景睿; 郭建魁; 惠玲; 哈小琴

    2011-01-01

    目的 探讨卡泊三醇软膏联合复方丙酸氯倍他索软膏外用治疗银屑病的近期临床疗效.方法 采用随机、开放、平行自身对照试验.将符合入选标准的93例慢性斑块型银屑病患者的皮损沿躯干中线分为左右两侧,采用随机数字法决定一侧躯干及肢体皮损为治疗组,给予外用复方卡泊三醇软膏,2次/d,复方丙酸氯倍他索软膏,1次/d,4周为1个疗程,与治疗部位相对应的另一侧躯干及肢体皮损为对照组,涂用丙酸氯倍他索软膏,2次/d,他扎罗汀乳膏,1次/d,疗程同治疗组.同时给予患者口服维生素C0.2,3次/d,叶酸10 mg,3次/d,部金银屑片0.96,3/d,窄谱中波紫外线治疗1次/3d.治疗前及治疗开始后每2周评估患者的症状积分,计算患者的症状积分指数(SSRI),评价治疗效果.结果 共有79例患者完成试验,治疗组D14、D28时SSRI分别为0.81±0.23与0.92±0.11,与对照组(0.53±0.17、0.64±0.23)相比差异均有统计学意义(均P<0.05);治疗组痊愈率D14为63.29%,D28为78.48%,与对照组(分别为39.24% 、50.63%)相比差异有统计学意义(均P<0.05);总有效率治疗组在D14为94.94%,D28为97.47%,与对照组相比较(D14为65.82%,D28为72.15%)差异均有统计学意义(均P<0.05).结论 卡泊三醇软膏联合复方丙酸氯倍他索软膏外用治疗寻常型银屑病具有肯定的疗效,未发现严重不良反应.%Objective To observe short-term outcomes of calcipotriol ointment combined compound clobetasol propionate ointment in psoriasis treatment. Methods A randomized, parallel, positive medicine self-controlled trial was administered in 93 subjects with chronic plaque psoriasis. Psoriatic lesions in every patients were divided to two parts according body surface medine line, ran-domized number were used to choose lesions on left or right body and limbs as treatment group which received external use of calci-potriol ointment, twice a day, compound clobetasol

  9. Effects of herbal ointment containing the leaf extracts of Madeira vine (Anredera cordifolia (Ten.) Steenis) for burn wound healing process on albino rats.

    Science.gov (United States)

    Yuniarti, Wiwik Misaco; Lukiswanto, Bambang Sektiari

    2017-07-01

    Skin burn is a health problem that requires fast and accurate treatment. If not well-treated, the burn will cause various damaging conditions for the patient. The leaf extract of Madeira vine (Anredera cordifolia (Ten.) Steenis), or popularly known as Binahong in Indonesia, has been used to treat various diseases. The purpose of this research is to determine the effects of leaf extracts of Madeira vine (A. cordifolia (Ten.) Steenis) on skin burn healing process in rats as an animal model. In this research, there were four treatment groups: G0, G1, G2, and G3, each consisting of five rats. All these rats were given skin burns, using hot metal plates. Then, sulfadiazine was given to G0, 2.5% leaf extract of Madeira vine was given to G1, 5% extract was given to G2, and 10% extract was given to G3, for straight 14 days topically, 3 times a day. At the end of the treatment period, skin excisions were conducted, and histopathological examination was carried out. Microscopic observation on the wound healing process on the collagen deposition, polymorphonuclear infiltration, angiogenesis, and fibrosis showed that G2 had a significant difference with G0, G1, and G3 (pMadeira vine, which have the antioxidant, anti-inflammatory, and antibacterial effects. The ointment from the 5% leaf extract of Madeira vine (A. cordifolia (Ten.) Steenis) has been proven to be effective to be used for topical burn therapy.

  10. Development of shampoo, soap and ointment formulated by green synthesised silver nanoparticles functionalised with antimicrobial plants oils in veterinary dermatology: treatment and prevention strategies.

    Science.gov (United States)

    Bansod, Sunita Dashrath; Bawaskar, Manisha Subrashrao; Gade, Aniket Krishnarao; Rai, Mahendra Kumar

    2015-08-01

    Many scientists have focused their research on the role of nanotechnology for the control of human pathogens, but there are also many topical pathogens present in animals, which infect animals and transfer to humans. Topical therapy is extremely important for the management of dermatological condition in animals. Therefore, the present study aims to evaluate the efficacy of biogenic silver nanoparticles (AgNPs) in combination with herbal oils against animal skin infections which may be responsible for causing infections in human beings. Here, the authors synthesised and characterised the AgNPs from Azadirachta indica. The oils were extracted from medicinal plants including Cymbopogon citratus, Cymbopogon martini, Eucalyptus globules, A. indica and Ocimum sanctum and the antifungal and antibacterial activity of plant oils along with AgNPs were evaluated. An excision wound model was used for the study of wound healing activity in rabbits. AgNPs functionalised oil has demonstrated remarkable antimicrobial activity against pathogens present on the skin of animals. The nano-functionalised antimicrobial oils were used in the formulation of shampoo, soap and ointment for veterinary dermatology. Antimicrobial products of plant origin with AgNPs are valuable, safe and have a specific role in controlling diseases. The authors believe that this approach will be a good alternative therapy to solve the continuous antibiotic resistance developed by many bacterial pathogens and will be utilised in various animal contacting areas in medicine.

  11. Simple and rapid method on High Performance Liquid Chromatography for simultaneous determination of benzylpenicillin potassium, streptomycin sulphate and related substances in Ascomicin – a veterinary use ointment

    Directory of Open Access Journals (Sweden)

    Neagu Maria

    2015-06-01

    Full Text Available A new simple, rapid, accurate and precise High – Performance Liquid Chromatography (HPLC method for determination of benzylpenicillin potassium and streptomycin sulphate in Ascomicin ointment was developed and validated. The method can be used for the detection and quantification of known and unknown impurities and degradation products in this pharmaceutical product during routine analysis and also for stability studies in view of its capability to separate degradation products. The method was validated for accuracy, precision, specificity, robustness and quantification limits according to ICH Guidelines. The estimation of benzylpenicillin potassium and streptomycin sulphate was done by Waters HPLC 2695. The chromatographic conditions comprised a reverse-phased C18 column (5 µm particle size, 250 mm×4.6 mm i.d. with a mobile phase consisting of a mixture of solution in water containing 0.025 M of sodium phosphate dibasic and 0.02 of sodium hexansulfonate adjusted to pH 6.0 with 22.5 g/lsolution of phosphoric acid and acetonitrile in gradient elution. The flow rate was 0.8 ml/min. Standard curves were linear over the concentration range of 5.00 µg/ml to 5.00 mg/ml for streptomycin sulphate and 3.26 µg/ml to 3.26 mg/ml for benzylpenicillin potassium. Statistical analyses proved the method was precise, reproducible, selective, specific and accurate for analysis of benzylpenicillin potassium, streptomycin sulphate and related substances.

  12. Formula optimization of the Jiashitang scar removal ointment and antiinflammatory compounds screening by NF-κB bioactivity-guided dual-luciferase reporter assay system.

    Science.gov (United States)

    Gao, Jie; Tao, Jin; Zhang, Nannan; Liu, Yanjie; Jiang, Min; Hou, Yuanyuan; Wang, Qian; Bai, Gang

    2015-02-01

    Inflammation plays a role in scar formation; therefore, decreasing inflammation benefits scar removal. Jiashitang scar removal ointment (JST) is a commercially available traditional Chinese medicinal formulation. It is composed of extracts from Carthamus tinctorius L. (Car), Rheum officinale Baill. (Rhe), Salvia miltiorrhiza Beg. (Sal), and Panax notoginseng (Burk.) F. H. Chen (Pan), which are all herbs with potent antiinflammatory activities. Our aims are to optimize the formula of JST and to elucidate its antiinflammatory active components. Response surface methodology was applied to optimize proportions of the four herb extracts. The antiinflammatory effects were evaluated using in vitro and in vivo models. To screen for active components in this formula, a bioactivity-based ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry analysis was performed. After optimization, the antiinflammatory effects of the new formula were significantly superior to the original one. Screening identified 13 active ingredients: a series of saffiomin, emodin, salvianolic acid, tanshinone, and triterpenoid saponin derivatives. These active ingredients were predicted to exert nuclear factor-κB inhibiting effects through MAPK, PI3K/AKT, and NIK-IKK pathways. In conclusion, the original formula was successfully optimized with more potent antiinflammatory activity. These methods can be applied to researches of other formulas.

  13. STA-21与卡泊三醇软膏治疗寻常型银屑病疗效比较%Comparison of STA-21 and Calcipotriol ointment in the treatment of psoriasis vulgaris

    Institute of Scientific and Technical Information of China (English)

    曾招林

    2013-01-01

    目的:比较STA-21与卡泊三醇软膏治疗寻常型银屑病的疗效。方法在26例寻常型银屑病患者对称部位选取临床表现、大小和部位相一致的皮损,分别外用0.2%STA-21软膏和卡泊三醇软膏治疗2周,记录治疗前后的PASI分值。结果治疗组有效率65.38%,高于对照组的46.15%,差异有统计学意义(P<0.001);两组均无严重不良反应。结论 STA-21治疗寻常型银屑病的疗效较卡泊三醇好。%Objective To compare STA-21 with calcipotriol ointment in treatment of psoriasis vulgaris. Methods The lesions in 26 patients with psoriasis vulgaris symmetrical parts selected clinical manifestations, size and location are consistent, topical 0.2%STA-21 ointment and calcipotriol ointment for 2 weeks, the PASI scores were recorded before and after treatment. Results The effective rate of the treatment group was 65.38%, 46.15% in the control group, the difference was statistically significant(P<0.001). The two groups had no serious adverse reactions. Conclusion The efficacy of STA-21 in treatment of psoriasis vulgaris than card berth three alcohol.

  14. 大鲵皮肤药膏和大鲵黏液药膏烫伤药理试验研究%The Pharmacological Research of Cure Burn by the Ointment of Giant Salamander's Skin and Mucus

    Institute of Scientific and Technical Information of China (English)

    陈曦; 王杨科; 陈德经

    2012-01-01

    The SD rat back deep II degree bum model was established to investigate the healing effect of the ointment of giant salamander (Andrias davidianus)'s skin and mucus. The results showed that the ointment of giant salamander's skin and mucus could not only shorten the time for the healing of the wounded surface of burnt rats. In addition, the oinlment of giant salamander's skin and mucus reduce the size of the wound and was fast than MEBO moist. Under the microscope, the phenomenon that the skin appendages in dermis were still in integrity was observed, and no edema or inflammatory cell infiltration was found. The ointment of giant salamander's skin and mucus promoted the healing of experimental rat's wounded surface.%建立了SD大鼠背部深Ⅱ度烫伤模型,研究大鲵皮肤药膏和大鲵黏液药膏对大鼠皮肤烫伤的治疗作用.结果表明,大鲵皮肤药膏、大鲵黏液药膏能明显缩短烫伤后大鼠创面愈合时间;创面愈合速度较美宝湿润烧伤膏组快,并能使创面面积明显缩小;显微镜下观察真皮内皮肤附件结构完整,未见水肿及炎性细胞浸润.大鲵皮肤药膏、大鲵黏液药膏具有促进实验大鼠烫伤创面愈合的作用.

  15. 黑豆馏油软膏治疗小儿湿疹疗效观察%Observation of the Curative Effect of Black Bean Distillate Oil Ointment in the Treatment of Infantile Eczema

    Institute of Scientific and Technical Information of China (English)

    高新; 刘亚萌; 郭艳芳

    2015-01-01

    Objective To observe the clinical curative ef ect of black bean distil ate oil ointment in the treatment of infantile eczema.Methods 110 cases of eczema were divided into the observation group and the control group,were treated with Bufexamac Cream and black bean distil ate oil ointment in treatment,the clinical ef icacy was compared between the two groups.Results After one week of treatment,two groups of children were significantly bet er in the control group,the total ef ective rate was 95.8%,total ef ective rate of observation group was 96.8%,the two groups showed no significant dif erence( >0.05).Conclusion The good ef ect of black bean distil ate oil ointment in the treatment of infantile eczema,but toxicity,long-term use,it is worth to promote the use.%目的:观察黑豆馏油软膏治疗小儿湿疹的临床疗效。方法将110例湿疹患儿分为对照组和观察组,分别予丁苯羟酸乳膏和黑豆馏油软膏外用治疗,比较两组临床疗效。结果治疗1w后,两组患儿均显著好转,其中对照组总有效率为95.8%,观察组总有效率为96.8%,两组相比无显著差异(>0.05)。结论黑豆馏油软膏治疗小儿湿疹疗效较好,可长期应用无毒副反应。

  16. 钙泊三醇倍他米松软膏治疗非泛发型白癜风的疗效观察%Effect of calcipotriol betamethasone ointment on treatment of non-generalized vitiligo

    Institute of Scientific and Technical Information of China (English)

    周隽; 李剑; 傅雯雯

    2013-01-01

    目的 观察钙泊三醇倍他米松软膏治疗非泛发型白癜风的临床疗效和安全性.方法 51例非泛发型白癜风患者外用钙泊三醇倍他米松软膏,每日1次涂于患处,连续使用3个月,每月1次观察临床疗效及不良反应.结果 51例患者中,痊愈8例,显效21例,好转10例,无效12例;显效率56.86%(29/51,复色面积≥50%),有效率76.47%(39/51,复色面积≥10%).结论 钙泊三醇倍他米松软膏治疗非泛发型白癜风安全、有效,不良反应小.%Objective To evaluate the therapeutic effect and safety of calcipotriol betamethasone ointment on the treatment of non-generalized vitiligo. Methods Calcipotriol betamethasone ointment was topically applied to the vitiliginous patches once daily in 51 patients with non-generalized vitiligo for 3 months, and the therapeutic effect and adverse effect were observed in each month. Results Of these 51 patients, 8 had complete repigmentation, 21 achieved excellent response, 10 experienced improvement, and the other 12 achieved almost no response. The excellent response rate was 56.86% (29/51, area of repigmentation ≥ 50% ), and the effective rate was 76.47% (39/51, area of repigmentation ≥ 10%). Conclusion Calcipotriol betamethasone ointment is effective and safe in the treatment of vitiligo, with less adverse effect.

  17. Effect of pre-operative octenidine nasal ointment and showering on surgical site infections in patients undergoing cardiac surgery.

    Science.gov (United States)

    Reiser, M; Scherag, A; Forstner, C; Brunkhorst, F M; Harbarth, S; Doenst, T; Pletz, M W; Hagel, S

    2017-02-01

    To evaluate the effect of pre-operative octenidine (OCT) decolonization on surgical site infection (SSI) rates. Before-and-after cohort study. Patients undergoing an elective isolated coronary artery bypass graft (CABG) procedure: control group (1(st) January to 31(st) December 2013), N=475; intervention group (1(st) January to 31(st) December 2014), N=428. The intervention consisted of nasal application of OCT ointment three times daily, beginning on the day before surgery, and showering the night before and on the day of surgery with OCT soap. A median sternotomy was performed in 805 (89.1%) patients and a minimally invasive direct coronary artery bypass procedure was performed in 98 (10.9%) patients. Overall, there was no difference in SSI rates between the control and intervention groups (15.4% vs 13.3%, P=0.39). The rate of harvest site SSIs was significantly lower in patients in the intervention group (2.5% vs 0.5%, P=0.01). Patients who had undergone a median sternotomy in the intervention group had a significantly lower rate of organ/space sternal SSIs (1.9% vs 0.3%, P=0.04). However, there was a trend towards an increased rate of deep incisional sternal SSIs (1.2% vs 2.9%, P=0.08). Multi-variate analysis did not identify a significant protective effect of the intervention (odds ratio 0.79, 95% confidence interval 0.53-1.15, P=0.27). Pre-operative decolonization with OCT did not reduce overall SSI rates in patients undergoing an elective isolated CABG procedure, but significantly decreased harvest site and organ/space sternal SSIs. Randomized controlled trials, including controlled patient adherence to the intervention, are required to confirm these observations and to determine the clinical utility of OCT in pre-operative decolonization. Copyright © 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

  18. Determination of Capsaicin in Capsaicin Ointment by HPLC%辣椒素乳膏中辣椒素含量的HPLC法测定

    Institute of Scientific and Technical Information of China (English)

    逄书明

    2014-01-01

    High performance liquid chromatography was performed on Phenomenex C18 column. The chromatographic conditions were as follows: methanol- water(70:30) as mobile phase, flow rate being 1.0 ml·min-1,the detecting wavelength at 280nm. Capsaicin had good linear relation within the range from 52.308μg·ml-1 to 98.804μg·ml-1 (r=0.9999). The average recovery was 99.43%, the repetitive RSD was 0.85%. The method is simple, rapid and accurate, which can be used for content determination of capsaicin in capsaicin ointment.%用HPLC法以Phenomenex C18色谱柱(150mm×4.6mm)为固定相,甲醇-水(70∶30)为流动相,流速1.0ml·min-1,进样量20μl,检测波长为280 nm,按外标法以峰面积计算测定辣椒素乳膏中辣椒素的含量。结果辣椒素在52.308μg·ml-1~98.804μg·ml-1范围内线性关系良好,相关系数 r=0.9999。平均回收率99.43%,RSD为0.85%。本法简便、准确、可靠,适用于辣椒素乳膏中辣椒素的含量测定。

  19. Comparison of Occlusive and Open Application in a Psoriasis Plaque Test Design, Exemplarily Using Investigations of Mapracorat 0.1% Ointment versus Vehicle and Reference Drugs.

    Science.gov (United States)

    Wigger-Alberti, Walter; Williams, Ragna; von Mackensen, Yi-Ling; Hoffman-Wecker, Maciej; Grossmann, Ulrike; Staedtler, Gerald; Nkulikiyinka, Richard; Shakery, Kaweh

    2017-01-01

    Psoriasis plaque tests (PPTs) are important tools in the early phases of antipsoriatic drug development. Two distinct PPT design variants (open vs. occluded drug application) are commonly used, but no previous work has aimed to directly compare and contrast their performance. We compared the antipsoriatic efficacy of mapracorat 0.1% ointment and reference drugs reported in 2 separate studies, representing open and occluded PPT designs. The drug effect size was measured by sonography (mean change in echo-poor band thickness), chromametry, and standardized clinical assessment. Antipsoriatic effects were detectable for the study drugs in both occluded and open PPTs. Differences between the potency of antipsoriatic drugs and vehicle were observable. The total antipsoriatic effect size appeared to be higher in the occluded PPT than the open PPT, despite the shorter treatment duration (2 vs. 4 weeks). Effect dynamics over time revealed greater differences between some study drugs in the open PPT compared to the occluded PPT. Taking the higher technical challenges for the open PPT into account, we recommend the occluded PPT as a standard screening setting in early drug development. In special cases, considering certain drug aspects or study objectives that would require procedural adaptations, an open PPT could be the better-suited design. Finally, both PPT models show clear advantages: classification as phase I studies, small number of psoriatic subjects, relatively short study duration, excellent discrimination between compounds and concentrations, parallel measurement of treatment response, and go/no go decisions very early in clinical development. © 2017 S. Karger AG, Basel.

  20. Comparing oil based ointment versus standard practice for the treatment of moderate burns in Greece: a trial based cost effectiveness evaluation

    Directory of Open Access Journals (Sweden)

    Carayanni Vilelmine J

    2011-12-01

    Full Text Available Abstract Background The local treatment of burn wounds has long been a subject of debate. The objective of this study was to compare the cost and the effectiveness of Moist Exposed Burn Ointment -MEBO versus a combination of povidone iodine plus bepanthenol cream for partial thickness burns. Methods The study was carried out in the Burn Center of a state hospital in Athens, Greece. 211 patients needing conservative therapy were prospectively selected according to the depth of the burn wound. The treatment was allocated according to the Stratified Randomization Design. The outcomes measured were mean cost of in-hospital stay, rate of complications, time of 50% wound healing, pain scores, in hospital stay diminution. We have adopted a societal perspective. Results In the total groups MEBO presented lower cost, (although not significantly different: p = 0.10 and better effectiveness. The data suggest that MEBO is the dominant therapy for superficial partial burn wound with significantly lower costs and significantly higher effectiveness due to a lesser time of recovery and consequently lower time of hospitalization and follow-up. MEBO presented similar percentages of complications with the comparator, lower pain levels and smaller time of no healthy appearance of the burn limits for superficial partial thickness burns. Conclusions The data suggested that topical application of MEBO may be considered for further investigation as a potential first-line treatment modality for superficial partial thickness burns. Trial registration The trial has been registered on the International Standard Randomised Controlled Trial Number Register (ISRCTN and given the registration number ISRCTN74058791.

  1. Use of collagenase ointment in conjunction with negative pressure wound therapy in the care of diabetic wounds: a case series of six patients

    Directory of Open Access Journals (Sweden)

    John D. Miller

    2015-01-01

    Full Text Available Background: Diabetic wounds with additional comorbidities are costly, time intensive, and difficult to heal. Often, multiple modalities may be necessary to achieve wound resolution, relying on the synergistic advantage of each therapy to affect wound healing. The selectivity of Clostridium collagenase is physiologically effective at degrading non-viable collagen fibers while preserving living collagen tissue. Additionally, negative pressure wound therapy (NPWT has long been used to aid wound healing while concurrently depreciating biological wound burden time. Methods: Six patients were selected from those appearing to our university based limb salvage service. Inclusion criteria included patients with a recurrent mixed fibrotic and granular wound base, in which NPWT was indicated, without exclusion criteria. Patients enrolled were administered clostridial collagenase ointment at each regularly scheduled NPWT dressing change. Patients were followed until healing, with visual representations of wound progression and time to full healing recorded. Results: Tandem application of these therapies appeared to expedite wound healing by clearing degenerative fibrous tissue and expediting wound granulation without additional complication. Unfortunately, not all patients were able to reach full healing; with two patients experiencing ulcer recurrence, likely a result of their significant comorbid nature. Conclusion: In our experience, we have noticed a specific subgroup of patients who benefit greatly when collagenase enzymatic debridement therapy is combined with NPWT. It is our belief that this combination therapy combines the molecular clearing of non-viable collagen with the wound granulation necessary to advance complex wounds to the next step in healing despite the current paucity in literature discussing this specific pairing.

  2. Determination of cholesterol oxides by gas chromatography-flame ionization detection/mass selective detection and their occurence in lanolin-containing cosmetics and ointments.

    Science.gov (United States)

    Schrack, S; Hohl, C; Schwack, W; Niederer, M; Roux, B

    2016-02-01

    Cholesterol oxides (COPs) are thought to be of toxicological relevance in cholesterol-containing foods. For cholesterol-containing cosmetics and the like, no information is available up to this date. Therefore, the first of two main aims of this study was to develop and validate a method for determining COPs in lanolin-containing cosmetics such as lipsticks and fatty creams as well as in nipple ointments. The second aim was to study the occurrence of COPs and their concentration levels in the respective product classes. The procedure is based on a published method for food comprising some necessary modifications. Sample preparation consisted of transesterfication, solid-phase extraction and silylation of target compounds. Separation of the derivatized COPs and their quantification were performed with gas chromatography (GC) using a flame ionization detector (FID) or a mass spectrometer (MS). The successful validation and the trouble-free application during the market survey showed that the method was fit for purpose. Total COP levels found were in the low per cent range (up to 3%) and surprisingly high, being many orders of magnitude higher than those published for foods. To our knowledge, we present for the first time a method for the determination of COPs in non-food consumer products. Furthermore, our study demonstrates that lanolin-containing cosmetics may be an additional exogenous source of COPs. We further show evidence, that at least part of the COPs are already formed on the sheep's wool. © 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

  3. Effects of herbal ointment containing the leaf extracts of Madeira vine (Anredera cordifolia (Ten. Steenis for burn wound healing process on albino rats

    Directory of Open Access Journals (Sweden)

    Wiwik Misaco Yuniarti

    2017-07-01

    Full Text Available Aim: Skin burn is a health problem that requires fast and accurate treatment. If not well-treated, the burn will cause various damaging conditions for the patient. The leaf extract of Madeira vine (Anredera cordifolia (Ten. Steenis, or popularly known as Binahong in Indonesia, has been used to treat various diseases. The purpose of this research is to determine the effects of leaf extracts of Madeira vine (A. cordifolia (Ten. Steenis on skin burn healing process in rats as an animal model. Materials and Methods: In this research, there were four treatment groups: G0, G1, G2, and G3, each consisting of five rats. All these rats were given skin burns, using hot metal plates. Then, sulfadiazine was given to G0, 2.5% leaf extract of Madeira vine was given to G1, 5% extract was given to G2, and 10% extract was given to G3, for straight 14 days topically, 3 times a day. At the end of the treatment period, skin excisions were conducted, and histopathological examination was carried out. Results: Microscopic observation on the wound healing process on the collagen deposition, polymorphonuclear infiltration, angiogenesis, and fibrosis showed that G2 had a significant difference with G0, G1, and G3 (p<0.05, while group G0 was significantly different from G1 and G3 (p<0.05. The better burn healing process on G2 allegedly because of the activity of flavonoid, saponin, and tannin, contained in the Madeira vine, which have the antioxidant, anti-inflammatory, and antibacterial effects. Conclusion: The ointment from the 5% leaf extract of Madeira vine (A. cordifolia (Ten. Steenis has been proven to be effective to be used for topical burn therapy.

  4. The Clinical Research on the Important Role for the Elephant Leather on the Sheng Ji Xiang Pi Ointment%生肌象皮膏中象皮作用与地位的临床研究

    Institute of Scientific and Technical Information of China (English)

    李京向; 陈宝元; 阎伯君; 关靖; 薛晓东

    2011-01-01

    Objective: Sheng Ji Xiang Pi Ointment, one of representative drugs of traditional Chinese medicine for external use,which has granulating functions,con treat various boils and sores,particularly to the stage of ulceration------pus and carrion almost vanished, skin and muscle has not growth yet. But wild elephants belong to the protected species and has been clearly prohibited to be killed and traded by the international organization. Then the Sheng Ji Xiang Pi Ointment can not be used any more as a result of no elephant leather. We try to realize the importance of elephant leather on the Sheng Ji Xiang Pi Ointment from the clinical re search. If elephant leather has an important role on the Sheng Ji Xiang Pi Ointment, then we try to make the best substitutes for el ephant leather in the future. Methods: 60 patients of chronic ulcers were randomly divided into two groups (treatment group and control group). Based on the control of blood sugar,infection and blood pressure and other basic treatment,ulcer wound was treated mainly with external treatment. Only when the most carrion had been discharged from the wound, did the two groups of patients are treated with Sheng Ji Xiang Pi Ointment and Sheng Ji Xiang Pi Ointment without elephant leather respectively, recorded in de tail the wound granulation, epithelialization, secretions and the pH of wound. Results :After 30 days, there had significant difference between the two groups(P<0.05)on the clinical effective rate,on the quality and the quantity of wound secretion,on the epitheli al growth and the growth of granulation,on the pH of wound of two groups,on the time when the wound began to secrete pus,grow epithelial and to grow fresh granulation. Conclusion : Elephant leather had an important effect in the Sheng Ji Xiang Pi Ointment and there was significant difference between Sheng Ji Xiang Pi Ointment and the Sheng Ji Xiang Pi Ointment without elephant leather on the clinical research.%目的:生肌象皮膏是具

  5. 复方丙酸氯倍他索软膏治疗慢性湿疹疗效观察%Efficacy of Clobetasol Propionate Compound Ointment for the Treatment of Chronic Eczema

    Institute of Scientific and Technical Information of China (English)

    缪文进; 沈利东; 黄鹂; 杨红; 陈亮

    2014-01-01

    目的:探讨复方丙酸氯倍他索软膏治疗慢性湿疹的有效性及安全性。方法将120例慢性湿疹患者随机分为两组:治疗组60例,给予复方丙酸氯倍他索软膏外涂,每日两次,共四周;对照组60例,给予卤米松乳膏外涂,每日2次,共4周,完成4周疗程后对两组患者进行疗效判断和比较,同时观察治疗中的不良反应。结果经复方丙酸氯倍他索软膏治疗的患者有效率75%,对照组有效率48.3%,治疗组疗效明显优于对照组(P<0.01),无不良反应。结论复方丙酸氯倍他索软膏治疗慢性湿疹安全有效。%Objective to discuss the efficacy and safety of clobetasol propionate compound ointment in patients with chronic eczema. Methods120 patients with chronic eczema were randomly divided into two groups. Group a (treatment group) with 60 patients were treated with clobetasol propionate compound ointment for minoxidil for four weeks twice daily. Group B (control group) with 60 patients were treated with halometasone cream for four weeks twice daily. The efficacy of patients in the two groups were determined and compared after completing four weeks treatment, and the adverse reactions during treatment were observed. Results in the treatment group, the effective rate of the cases treated with clobetasol propionate compound ointment was 75%, while that of the control group was 48.3%, the efficacy of treatment group was significantly better than that of control group with no adverse effects in all groups(P<0.01). Conclusion clobetasol propionate compound ointment is safe and effective in treatment of chronic eczema.

  6. 他克莫司软膏治疗口腔扁平苔藓的临床分析%Clinical Study on Tacrolimus Ointment in Treatment of Oral Lichen Planus

    Institute of Scientific and Technical Information of China (English)

    李桂香

    2015-01-01

    目的:探究口腔扁平苔藓患者采用他克莫司软膏治疗的方法和效果。方法选取2013年3月~2014年9月收治的35例口腔扁平苔藓患者进行治疗,随机分组,实验组18例患者选择他克莫司软膏的治疗,对照组17例患者选择患者卤米松乳膏的使用,观察治疗后的改善情况。结果实验组治疗有效率为94.44%,对照组治疗有效率为82.35%,差异显著,且两组患者不良反应率也有较大差异(P均<0.05)。%Objective To explore treatment method and its effect of Tacrolimus ointment in treatment of oral lichen planus. MethodsChoose 35 patients of oral lichen planus who are treated in hospital from March 2013 to September 2014 and separate them into two groups at random, 18 patients in study group are given Tacrolimus ointment treatment, while 17 patients in control group are given Halometasone ointment treatment, and then make a comparative study on patients’ recovery between two groups. ResultsPatients’ treatment efifcacy in study group is up to 94.44%, while patients’ treatment efifcacy in control group is up to 82.35%; there is a great differential between two groups in terms of treatment efifcacy as well as side-effect incidence and such a differential has statistic value(P<0.05). Conclusion Tacrolimus ointment is of efifcacy in treatment of oral lichen planus; it is conducive to relieving patients’ pain in short time without any side effect; and such a treatment method is quite safe and efifciency, therefore, it is worthwhile to be promoted widespread.

  7. 经皮反复给予玉红膏对大鼠器官毒性的研究%Organ toxicity of Yuhong Ointment(玉红膏) after repeated transdermal administration in rats

    Institute of Scientific and Technical Information of China (English)

    胡小靖; 孙新民; 黄雯; 邱恒; 牟稷征; 王丽霞; 王旗

    2013-01-01

    Objective To observe the effects of Yuhong Ointment on rat's liver and kidney functions and histomorphology of heart,brain,liver,kidney and spleen after transdermal administration repeatedly,in order to provide experimental evidences for safe use of Yuhong Ointment in clinical practice.Methods A total of 100 SPF SD rats of equal number of both genders,weighting 200 g,were divided into 5 groups:matrix control group,1 time concentration of Yuhong Ointment group (containing 0.4% calomel),2 times concentration of Yuhong Ointment group (containing 0.8% calomel),4 times concentration of Yuhong Ointment group (containing 1.6% calomel) and calomel group (containing 1.6% calomel) by drawn lots randomly,each group comprised 20 rats.The model of rat's skin injury was prepared.Yuhong Ointment in different concentrations were applied on the skin-impaired once daily for 28 days.The levels of alanine aminotransferase (ALT),aspartate aminotransferase (AST),blood urea nitrogen (BUN),creatinine (Cr) and N-acetyl beta-D glucosaminidase (NAG) of rats in different groups were measured before treatment,14 and 28 days after treatment,and 28 days after drug withdrawal,respectively.Ten rats in every group were sacrificed on 28 days after treatment and 28 days after drug withdrawal,respectively.The heart,brain,liver,kidney,and spleen of rats in different groups were taken and weighed up.The organ coefficients were calculated and the histomorphological changes of liver,kidney and spleen were examined.Results There were no statistically significant differences in levels of serum ALT、AST、BUN、Cr and NAG in rats among the different concentrations of Yuhong Ointment groups,1.6% calomel group and matrix control group (all P > 0.05).The level of serum Cr in rat of 1.6% calomel group was significantly higher than that of matrix control group 28 days after drug withdrawal (P < 0.05).The kidney coefficients of rats in 2 times and 4 times concentration of Yuhong Ointment group and

  8. Oxidative Damage to Nucleic Acids and Benzo(apyrene-7,8-diol-9,10-epoxide-DNA Adducts and Chromosomal Aberration in Children with Psoriasis Repeatedly Exposed to Crude Coal Tar Ointment and UV Radiation

    Directory of Open Access Journals (Sweden)

    Lenka Borska

    2014-01-01

    Full Text Available The paper presents a prospective cohort study. Observed group was formed of children with plaque psoriasis (n=19 treated by Goeckerman therapy (GT. The study describes adverse (side effects associated with application of GT (combined exposure of 3% crude coal tar ointment and UV radiation. After GT we found significantly increased markers of oxidative stress (8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine, significantly increased levels of benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE DNA adducts (BPDE-DNA, and significantly increased levels of total number of chromosomal aberrations in peripheral lymphocytes. We found significant relationship between (1 time of UV exposure and total number of aberrated cells and (2 daily topical application of 3% crude coal tar ointment (% of body surface and level of BPDE-DNA adducts. The findings indicated increased hazard of oxidative stress and genotoxic effects related to the treatment. However, it must be noted that the oxidized guanine species and BPDE-DNA adducts also reflect individual variations in metabolic enzyme activity (different extent of bioactivation of benzo[a]pyrene to BPDE and overall efficiency of DNA/RNA repair system. The study confirmed good effectiveness of the GT (significantly decreased PASI score.

  9. 肤痔清软膏在中重度寻常痤疮患者中的应用%Application of Fuzhiqing ointment in the treatment of moderate to severe acne vulgaris

    Institute of Scientific and Technical Information of China (English)

    梁国雄; 胡宝婵; 余嘉明; 王俊秀

    2014-01-01

    Objective To investigate the application of Fuzhiqing ointment in the treatment of moderate to severe acne vulgaris. Methods 400 patients with moderate to severe acne vulgaris were randomly divided (100 cases each) into topical group (Fuzhiqing ointment for topical use), routine group (routine oral drugs), combination group (Fuzhiqing ointment and routine oral drugs) and mask group (routine oral drugs and Fuzhiqing ointment used for fa-cial mask). Efficacy and adverse reactions were observed for 4 weeks. Results There was no statistical difference of effective rate between topical group and routine group. The effective rate of combination group was higher than that of topical group. The effective rate of mask group was 87%, which was higher than those of other groups and all the dif-ferences were statistical significant. 4 patients felt mild epigastric discomfort and 1 patient in mask group had mild fa-cial flushing and burning. All these adverse reactions needed no treatment. Conclusion For treating patients with moderate to severe acne vulgaris, Fuzhiqing ointment has the advantages of good efficacy and high safety. It was bet-ter when performed with facial mask combined with routine treatment. It was worthy of clinical popular application.%目的:探讨肤痔清软膏对中重度寻常痤疮的临床治疗作用。方法400例中重度寻常痤疮患者随机分为外用组(只外涂肤痔清软膏)、常规组(常规口服药物治疗)、联合组(常规口服药物联合外涂肤痔清软膏)和倒膜组(常规口服药物联合外涂肤痔清软膏和面部倒膜治疗)各100例,给予相应治疗4周,观察疗效和不良反应。结果外用组与常规组的有效率差异无统计学意义(P>0.05),联合组的有效率优于外用组,倒膜组的有效率为87.00%,优于其余各组,其差异均有统计学意义(P<0.05)。有4例患者出现轻微上腹部不适,倒膜组有1例患者出现面部轻微潮红和烧灼感

  10. Experimental research of tacrolimus ointment in the treatment of allergic contact dermatitis in mice%他克莫司软膏对小鼠变应性接触性皮炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    冯峥; 刘丹; 焦泽龙; 赵梓纲; 李恒进

    2013-01-01

      Objective: To study the efficacy of tacrolimus ointment in the treatment of allergic contact dermatitis in mice. Methods:The DNCB was applied on the dorsum of mice to produce the allergic contact dermatitis models. A total of sixty mice were randomly divided into normal control group, model group, halometasone cream group, momestasone furoate group, hydrocortisone butyrate cream group and tacrolimus ointment group, with 10 mice in each group. The distinctions of inflammation degree of skin lesion, quantity of inflammatory cell in histopathological section, and levels of IL-4 and IFN-γin lesion were detected. Results: Application of the tacrolimus ointment can effectively alleviate the inflammation degree of lesion on dorsum of mice, reduce quantity of inflammatory cell in histopathology, and adjust the levels of IL-4 and IFN-γ. The treatment effect of the tacrolimus ointment was equivalent to that of the halometasone cream, and was superior to that of the momestasone furoate and hydrocortisone butyrate cream. Conclusion:Topical tacrolimus ointment had the obvious treatment effect on allergic contact dermatitis.%  目的:评价他克莫司软膏治疗小鼠变应性接触性皮炎的疗效。方法:使用2,4-二硝基氯苯(DNCB)诱导小鼠背部变应性接触性皮炎,制造模型成功后,将60只小鼠随机分为正常对照组、模型组、卤米松组、糠酸莫米松组、丁酸氢化可的松、他克莫司组,每组10只,分别接受相应药物的治疗。观察各组小鼠皮损炎症程度、组织病理切片炎症细胞数量改变及皮损中IL-4和IFN-γ水平的变化。结果:他克莫司软膏能有效减轻小鼠背部皮损炎症程度,减少组织病理切片炎症细胞数量,调节皮损中IL-4和IFN-γ的水平;其疗效与卤米松相当,优于糠酸莫米松及丁酸氢化可的松。结论:他克莫司软膏对小鼠变应性接触性皮炎具有明显的治疗作用。

  11. Dose-toxic relationship of Zhuhong Ointment on damaged skin model rats%朱红膏对皮肤破损模型大鼠量毒关系研究

    Institute of Scientific and Technical Information of China (English)

    林含; 张旭辉; 董建勋; 李建荣; 贺蓉; 彭博; 路艳丽

    2013-01-01

    Objective: To study the dose-toxic relationship of Zhuhong Ointment on damaged skin model rat. Methods: SD rats were randomly divided into the impairment control group, and high-, middle-, low-dose Zhuhong ointment groups. Each group was treated by corresponding methods for 4 weeks, and recovery 4 weeks. Hematological parameters, kidney and liver function, PT, APTT, NAG and β2-MG contents in urine were taken as monitoring indexes, and the level of mercury in urine, blood and kidney were tested, and the pathological morphology changes of kidney were observed. Results: After treatment for 4 weeks, compared with impairment control group, the level of mercury in urine, blood and kidney in every dose group increased significantly (P<0.01). And the relation existed between toxicity and dose on Zhuhong ointment. After recovery for 4 weeks, the level of mercury in urine and blood in every dose group restored normal, while the level of mercury in kidney in high- dose groups still increased (P<0.01). The kidney coefficient and the level of NAG increased only in high-dose group (P<0.01). There was no significant difference in NAG contents between Zhuhong ointment groups and the impairment control group. Conclusion: Excess using Zhuhong Ointment repeatedly may lead to pathological morphology changes of kidney and abnormal hepatic function, and enhance the accumulation of mercury.%目的:探讨朱红膏对破损皮肤模型大鼠的量毒关系.方法:随机将大鼠分成对照组、朱红膏低、中、高剂量(19.04、38.08、76.16mg生药/kg)4组.分别于连续给药4周和停药4周后,测定汞含量、β-N-乙酰胺基葡萄糖苷酶(NAG)、碘[125I]β2-微球蛋白(BMG)、丙氨酸转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、肌酐(Scr)、尿素氮(BUN)、血常规、相关凝血指标、脏器系数,同时进行肾脏组织形态学观察.结果:连续给药4周,朱红膏低、中、高剂量组血、尿汞和肾汞含量与对

  12. Economic analysis and budget impact of clostridial collagenase ointment compared with medicinal honey for treatment of pressure ulcers in the US

    Directory of Open Access Journals (Sweden)

    Mearns ES

    2017-08-01

    Full Text Available Elizabeth S Mearns,1 Michael Liang,1 Brendan L Limone,1 Adrienne M Gilligan,1 Jeffrey D Miller,1 Kathleen D Schaum,2 Curtis R Waycaster2 1Truven Health Analytics, an IBM Company, Cambridge, MA, USA; 2Smith & Nephew, Inc., Fort Worth, TX, USA Objectives: Pressure ulcer (PU treatment poses significant clinical and economic challenges to health-care systems. The aim of this study was to assess the cost-effectiveness and budget impact of enzymatic debridement with clostridial collagenase ointment (CCO compared with autolytic debridement with medicinal honey (MH for PU treatment from a US payer/Medicare perspective in the hospital outpatient department setting.Methods: A cost-effectiveness analysis using a Markov model was developed using a 1-week cycle length across a 1-year time horizon. The three health states were inflammation/senescence, granulation/proliferation (ie, patients achieving 100% granulation, and epithelialization. Data sources included the US Wound Registry, Medicare fee schedules, and other published clinical and cost studies about PU treatment.Results: In the base case analysis over a 1-year time horizon, CCO was the economically dominant strategy (ie, simultaneously conferring greater benefit at less cost. Patients treated with CCO experienced 22.7 quality-adjusted life weeks (QALWs at a cost of $6,161 over 1 year, whereas MH patients experienced 21.9 QALWs at a cost of $7,149. Patients treated with CCO achieved 11.5 granulation weeks and 6.0 epithelization weeks compared with 10.6 and 4.4 weeks for MH, respectively. The number of clinic visits was 40.1 for CCO vs 43.4 for MH, and the number of debridements was 12.3 for CCO compared with 17.6 for MH. Probabilistic sensitivity analyses determined CCO dominant in 72% of 10,000 iterations and cost-effective in 91%, assuming a benchmark willingness-to-pay threshold of $50,000/quality-adjusted life year ($962/QALW. The budget impact analysis showed that for every 1% of patients

  13. 耳内镜下复方酮康唑、氧化锌软膏治疗慢性外耳道炎的临床疗效%Under endotoscope compound ketoconazole zinc oxide ointment in the treatment of chronic otitis externa

    Institute of Scientific and Technical Information of China (English)

    黄涛

    2015-01-01

    目的:探讨耳内镜下复方酮康唑软膏、氧化锌软膏治疗慢性外耳道炎的疗效.方法:收治慢性外耳道炎患者82例,耳内镜下外耳道涂抹复方酮康唑、氧化锌软膏等治疗.结果:1周后复诊,治愈58例,治愈率70.7%;2周后复诊,治愈74例,治愈率90.2%,治疗效果满意.结论:耳内镜下采用复方酮康唑软膏、氧化锌软膏等治疗慢性外耳道炎具有满意的疗效.%Objective:To explore the curative effect of under endotoscope compound ketoconazole ointment and zinc oxide ointment in the treatment of chronic otitis externa.Methods:82 patients with chronic otitis externa were selected.They were given compound ketoconazole and zinc oxide ointment treatment in external auditory canal under endotoscope.Results:After 1 week of subsequent visit,58 cases were cured,the cure rate was 70.7%.After 2 weeks of subsequent visit,74 cases were cured,the cure rate was 90.2% .The treatment effect was satisfactory.Conclusion:Using compound ketoconazole ointment and zinc oxide ointment under endotoscope in the treatment of chronic otitis externa have satisfactory curative effect.

  14. 白脉软膏与巴氯芬治疗脑卒中患者肌痉挛的疗效比较%Comparison of the effects of Baimai ointment and baclofen in stroke patients with spasticity

    Institute of Scientific and Technical Information of China (English)

    李亮; 陶林花; 施明; 任芸; 尹汉逵; 王月丽; 孙燕; 林斯捷

    2016-01-01

    Objective To compare the effects of Baimai ointment and baclofen in stroke patients with spas-ticity.Methods 84 cases accompanied by limb spasticity in stroke patients by digital table were randomly divided into Baimai ointment group and baclofen group,42 cases in each group.The Baimai ointment group were treated with Baimai ointment on the spastic limbs,the baclofen group received oral baclofen tablets 30 -75mg/days for 2 weeks, 4 weeks,8 weeks.The curative effects of the two groups were compared before and after treatment.Results Before and after treatment in the two groups,the levels of spasticity,pain and activities of daily living (ADL)differences were statistically significant and Baimai ointment in the treatment of spasm.After 4 weeks and 8 weeks,the Ashworth score of the Baimai ointment group were (1.59 ±0.46)points,(0.89 ±0.56)points,and those of baclofen group were (1.75 ±0.64)points,(1.45 ±0.48)points,the differences were statistically significant(t values were 2.916, 3.367,all P <0.05).After 2 weeks,4 weeks and 8 weeks,the VAS score of the Baimai ointment group were (2.72 ± 0.54)points,(2.02 ±0.24)points,(1.24 ±0.12)points,and baclofen group were (3.56 ±0.44)points,(3.15 ± 0.48)points,(2.58 ±0.26)points,the differences were statistically significant(t values were 2.975,3.359,5.416, all P <0.05),activities of daily living (ADL)was higher than that of the baclofen group.After 8 weeks,the MBI score of the Baimai ointment group was (64.46 ±10.78)points,and baclofen group was (50.74 ±9.18)points,the difference was statistically significant between the two groups (t values was 3.562,P <0.05).Conclusion Baimai ointment has the better antispasmodic effect than baclofen in patients with stroke.%目的:比较白脉软膏与巴氯芬改善脑卒中患者肌痉挛的疗效。方法将84例伴有肢体痉挛的脑卒中患者按数字表法随机分为白脉软膏组和巴氯芬组,每组42例,白脉软膏组予痉挛肢体外用白脉软膏,巴

  15. CURATIVE EFFECT OF COUNPOUND CLOBETASOL PROPIONATE OINTMENT ON NEURODEMATITIS%复方丙酸氯倍他素软膏治疗神经性皮炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    滕以姒

    2014-01-01

    Objective To observe the therapeutic efficacy and safety of compound clobetasol propionate ointment in the treatment of neurodermatitis .Methods A total of 147 patients with neurodermatitis were randomly divided into the treatment group (73 cases) treated with compound clobetasol propionate oint-ment and the contrast group (74 cases) treated with halometasone cream .The course of treatment for both groups was 4 weeks ,2 times a day .The clinical effects in two groups were compared .Results Both the curative rate (78 .08% ) and the obviously effective rate (98 .6% ) in the treatment group were higher than those (62 .16% and 89 .19% ) in the contrast group respectively .There was significant difference between the two groups (P<0 .05) .Conclusion In the treatment of neurodermatitis ,the use of compound clobeta-sol propionate ointment can produce better curative effects than halometasone cream .%目的:观察复方丙酸氯倍他素软膏治疗神经性皮炎的疗效及安全性。方法147例神经性皮炎患者随机分为两组,治疗组73例用复方丙酸氯倍他索软膏外搽,对照组74例用卤米松乳膏外搽,2次/d ,疗程均为4周。结果治疗组痊愈率(78.08%)高于对照组痊愈率(62.16%),治疗组总显效率(98.63%)高于对照侧总显效率(89.19%),差异均有统计学意义( P <0.05)。结论复方丙酸氯倍他索软膏治疗神经性皮炎,疗效优于卤米松乳膏。

  16. 复方丙酸氯倍他索软膏治疗寻常型银屑病临床疗效观察%Clinical Curative Effect Observation on Compound Clobetasol Propionate Ointment in the Treatment of Psoriasis Vulgaris

    Institute of Scientific and Technical Information of China (English)

    王建国; 顾艳丽; 王欣

    2015-01-01

    Objective To observe the clinical efficacy and safety on compound clobetasol propionate ointment in the treatment of psoriasis vulgaris.Methods 153 cases of patients with psoriasis vulgaris were randomly divided into treatment group(compound clobetasol propionate ointment)and the control group 1(0.05% clobetasol propionate cream),control group 2(0.025% of al trans retinoic acid cream),and observed the curative effect.Results After comparing the treatment group and the control group 1,control group 2,the effective rate was significantly different(P0.9) no difference. The treatment group was better than the two control group.Conclusion Compound clobetasol propionate ointment is a safe,effective and innovative compound external preparation in the treatment of psoriasis vulgaris,curative effect is better than that of the same concentration of preparations and the compliance of the patients is higher.%目的:观察复方丙酸氯倍他索软膏治疗寻常型银屑病的临床疗效和安全性。方法选取寻常型银屑病患者153例随机分成治疗组(复方丙酸氯倍他索软膏)和对照1组(0.05%丙酸氯倍他索霜)、对照2组(0.025%全反式维甲酸霜),并观察各组疗效。结果治疗组与对照1组、对照2组比较,有效率均有显著性差异(P0.9)无差异。治疗组疗效优于两对照组。结论复方丙酸氯倍他索软膏是治疗寻常型银屑病的一种安全、有效的创新复方外用制剂,疗效优于同等浓度的单方制剂且患者的依从性较高。

  17. Injection of Tobramycin ointment for treatment of lacrimal passages obstruction of infant%妥布霉素眼膏注入泪道治疗婴幼儿泪道阻塞

    Institute of Scientific and Technical Information of China (English)

    帖红艳; 李志宏; 张鑫; 雷方

    2014-01-01

    目的 探讨泪道冲洗探通术后应用妥布霉素眼膏泪道注入泪道治疗婴幼儿泪道阻塞的临床效果.方法 对86例(161眼)30 d~1.5岁婴幼儿泪道阻塞行泪道冲洗探通术后应用妥布霉素眼膏注入泪道,观察治疗后泪道通畅情况.结果 随访3~4月,治愈率100%,其中泪道冲洗探通1次治愈者109眼(67.7%),2~3次治愈者36眼(22.36.0%),治疗3次以上者16眼(9.94%).结论 泪道冲洗探通术后妥布霉素眼膏注入泪道治疗婴幼儿泪道阻塞安全、经济、疗效肯定.%Objective To study the clinical effect of irrigation and probing of lacrimal passages combined with injection of tobramycin eye ointment into lacrimal passage in the treatment of infantal lacrimal passages obstruction.Methods One hundred and sixty one eyes of 86 infants with lacrimal passages obstruction were treated with irrigation and probing of lacrimal passages combined with injection of tobramycin eye ointment into the lacrimal passages.The change of the patency of lacrimal passages after treatment was observed.Results After 3-4 months,all the 161 eyes were cured (100%).Of them,109 eyes (67.70%) were cured after only 1 time treatment,36 eyes (22.36%) were cured after 2-3 times treatment and 16 eyes (9.94%) were cured for more than 3 times treatment.Conclusion Irrigation and probing of lacrimal passages combined with injection of tobramycin eye ointment into lacrimal passage for treatment of lacrimal passages obstruction is simple,economic,and efficient.

  18. 损伤灵与喜疗妥软膏治疗动静脉内瘘皮下血肿对照研究%INJURY SPIRIT AND HIRUDOID OINTMENT FOR THE TREATMENT OF ARTERIOVENOUS FISTULA HEMATOMA CONTROL STUDY

    Institute of Scientific and Technical Information of China (English)

    李丽

    2015-01-01

    Objective To investigate the damage ointment topical treatment of arteriovenous fistula sub‐cutaneous hematoma with Hirudoid cream ‐control study clinical efficacy .Methods Our hospital dialysis centers the arteriovenous fistula subcutaneous hematoma 64 patients were randomly divided into observa‐tion group and control group ,the control group ,according to conventional observation group damage oint‐ment topical ointment to smear Hirudoid observe and record two groups of patients with hematoma subsi‐ded ,duration of pain ,whether the formation of subcutaneous induration and dialysis blood flow were compared therapeutic effect .Results The two groups of patients in the subcutaneous hematoma subsided time , duration of pain ,the formation of subcutaneous indu‐ration , dialysis blood flow statistically significant difference ( P < 0 .05 ) .Conclusion The injury ointment topical treatment of arteriovenous fistula the sub‐cutaneous hematoma efficacy ,should be widely applied .%目的:通过与喜疗妥软膏对照研究探讨损伤灵软膏外敷治疗动静脉内瘘皮下血肿临床疗效。方法选择我院透析中心出现动静脉内瘘皮下血肿的64例患者,随机分成观察组和对照组,观察组使用损伤灵软膏外敷,对照组按常规使用喜辽妥软膏涂沫,观察并记录两组患者皮下血肿消退时间、疼痛持续时间、是否形成皮下硬结及透析血流量情况,比较两组治疗效果。结果两组患者在皮下血肿消退时间、疼痛持续时间、皮下硬结形成,透析血流量情况在统计学上有显著性差异(P<0.05)。结论损伤灵软膏外敷治疗动静脉内瘘皮下血肿疗效确切,值得推广应用。

  19. 三黄膏与生肌膏联合治疗Ⅲ、Ⅳ期压疮的疗效分析%The effect of Sanhuang plaster and Myogenic ointment on stage m and Ⅳ bedsore

    Institute of Scientific and Technical Information of China (English)

    蔡淑珍; 梁华; 谭贵英

    2012-01-01

    Objective To discuss the effect of Sanhuang plaster and Myogenic ointment on stage Ⅲ and Ⅳ bedsore.Methods Sixty - eight patients with bedsore were divided into experimental group of 34 patients and control group of 34 patients.The patients of two groups were treated with sponge or alternate inflatable cushion for decompression,keeping skin clean and dry,helping rolling massage,nutrition intervention,debridement to remove necrotic tissue and clean the wound with normal saline and related whole - body treatment.The experimental group was also added with Sanhuang plaster and Myogenic ointment,while the control group was given external apphcation with antibiotics.The treatment analysis was made on the 21st day and the 35th day of the treatment.Results The treatment efficiency and the cure rate of the experimental group were obviously higher than those of the control group,the healing time was significantly shorter than that of control group ( both are p < 0.05 ).Conclusions Applying Sanhuang plaster and Myogenic ointment to the treatment of stage Ⅲ and Ⅳ bedsore can obviously shorten the healing time and improve the cure rate.%目的 探讨三黄膏与生肌膏联合治疗Ⅲ、Ⅳ期压疮的效果.方法 将68例压疮患者分为实验组和对照组各34例,两组患者均给予海绵垫或交替式充气垫减压、保持皮肤清洁干燥、协助翻身按摩、营养干预、清创去除坏死组织、生理盐水清洗创面等压疮护理措施及相应的全身治疗,实验组加用三黄膏与生肌膏外敷,对照组加用抗生素外敷.于治疗第21天、第35天进行治疗效果分析.结果 实验组患者治疗有效率及治愈率明显高于对照组,愈合时间明显短于对照组(均为P<0.05),差异有统计学意义.结论 应用三黄膏与生肌膏联合治疗Ⅲ、Ⅳ期压疮可明显缩短愈合时间,提高治愈率.

  20. 0.03%他克莫司软膏治疗眼睑皮炎临床疗效观察%Clinial efficacy of 0.03% tacrolimus ointment for atopic blepharitis

    Institute of Scientific and Technical Information of China (English)

    李红; 彭建梅; 伍健华; 刁仕华

    2011-01-01

    Objective To investigate the clinical efficacy of 0.03%tacrolimus ointment in patients with atopic blepharitis .Methods Twentysix patients were treated with 0.03%tacrolimus ointment twice a day for 2 weeks,and the clinical symptom and sign scores were recorded before and after treatment .Results The clinical cured rate was 57.69%,76.94%,92.30%and 73.08%at the 3th day,7th day,14th day and 30th day after treatment respectively .Among a varicty of skin lesions ,the therapeutic effect was better for erythema and inching than for xerosis cutis and chickening.Four cases (15.38%)were reported to have local burning ,which all happened in the first 3 day of teatment .There are 7(26.92%)patients who recurrent after withdraw of the treatment .Conclusion 0.03%tacrolimus ointment is an effective treatment option for the jpatients with atopic blepharitis .Long-term efficacy and safety of the medicine have to be evaluatcd by long -term follow-up studies.%目的 探讨0.03%他克莫司软膏治疗眼睑部皮炎的疗效.方法 26例患者外用0.03%他克莫司软膏,2次/d,共2周.于治疗前及治疗后第3天,第1、2周和停约后1月各随访1次.结果 26例患者治疗后3天、1周、2周及停药1个月后临床痊愈率分别为57.69%,76.94%,92.30%,73.08%.对红斑、瘙痒的控制起效迅速,而脱屑及肥厚改变较缓.4例(15138%)患者局部有灼热感,均发生在治疗初3大.停药1个月后共有7例(26.92%)患者复发.结论 0.03%他克莫司软膏治疗眼睑部皮炎起效快,疗效明显,长期使用的安全性需大样本观察研究.

  1. Comparison of the curative effects of Diclofenac Diethylamine Emulgel and Qizheng Qingpeng ointment on shoulder periarthritis%扶他林乳胶剂和奇正青鹏膏剂治疗肩周炎的疗效比较

    Institute of Scientific and Technical Information of China (English)

    沈洲; 徐福祥; 樊盛军; 胡海涛; 陈文军; 张鹏

    2012-01-01

    Objective It is to evaluate the efficacy of Diclofenac Diethylamine Emulgel and Qizheng Qingpeng ointment on periarthritis of shoulder. Methods 180 patients with periarthritis of shoulder were randomly divided into groupA ( n = 90 ) and group B( n =90 ). Group A was treated with Diclofenac Diethylamine Emulgel and group B was treated with Qizheng Qingpeng ointment. Both the treatment courses were two weeks. Their therapeutic effects and safety were assessed. Results After treatment, pains were improved in both groups, but compared with each other, the difference was not significant. The improvement of function of shoulder joint in group A was significantly better compared to B group. Conclusion Diclofenac Diethylamine Emulgel and Qizheng Qingpeng ointment both can relive the pain caused by periarthritis of shoulder. Diclofenac Diethylamine Emulgel is remarkably more effective in improving the function of shoulder joint, used safely and conveniently.%目的 探讨扶他林乳胶剂和奇正青鹏膏剂治疗肩周炎的疗效.方法 将180例肩周炎患者随机分为A组90例和B组90例.A组采用扶他林乳胶剂治疗,B组采用奇正青鹏膏剂治疗,疗程2周,评估2组疗效和安全性.结果 治疗2周后,2组疼痛均有改善,2组间比较无显著性差异;肩关节功能改善情况A组优于B组.结论 扶他林乳胶剂和奇正青鹏膏剂均能迅速减轻肩周炎患者的疼痛,但在改善肩关节活动功能方面扶他林乳胶剂效果更好,且使用安全、方便.

  2. 双黄烧伤膏对大鼠烧伤、烫伤的治疗作用研究%Experimental studies of shuanghuang burn ointment treatment for scald and burn wound of rat model

    Institute of Scientific and Technical Information of China (English)

    朱晓红; 凌磊; 王杨; 王强

    2012-01-01

    目的 研究双黄烧伤膏对大鼠实验性烫伤、烧伤感染的治疗作用.方法 将大鼠随机分为实验组(双黄烧伤膏组)、阳性对照组(京万红软膏组)、空白对照组.建立大鼠Ⅱ度烫伤模型、Ⅲ度烧伤感染模型,分别涂布给药,单笼饲养,观察并记录创面变化.结果 在大鼠烫伤实验中,给药15 d后,各组创面结痂面积明显变小,实验组结痂愈合时间短,与阳性对照组、空白对照组比较,差异有统计学意义(P0.05),与空白对照组相比,差异有统计学意义(P0.05),与阴性对照组相比,差异有统计学意义(P<0.01).结论 双黄烧伤膏对大鼠实验性烫伤、烧伤感染具有较好的治疗作用.%Objective To study the effects of shuanghuang burn ointment on scald and burned infectious rats. Methods Rats were randomly divided into test group( shuanghuang burn ointment ), positive control group( jingwan-hong cream )and no treatment group respectively. The drugs were administered topically on the surface of scalded and burned infection places respectively after partical-thickness scald and burn in rats. The change of the scalded and burned areas and the decrustation time were recorded. Results In the partical-thickness scalding test,the scalded areas of 15 d were smaller, there was significant difference between test group and positive control group( P < 0. 05 ), there was significant difference between test group and no treatment group( P < 0. 01 ); the scalded areas of 20 d: there was significant difference between test group and no treatment group( P <0. 01 ),but there was no significant difference compared with the positive control group. In the partical-thickness burnning infection test,the scalded areas of 9 d,there was significant difference between the test group and the no treatment group( P <0. 01 ) ,but there was no significant difference compared with the positive control group. Conclusion Burn ointment has a good anti-inflammatory, antibacterial and

  3. 喜疗妥软膏在治疗静脉留置针致静脉炎中的应用%Application of hirudoid ointment in the treatment of phlebitis caused by venous indwelling needle

    Institute of Scientific and Technical Information of China (English)

    黄艳玲

    2014-01-01

    Objective:To explore the effect of hirudoid ointment in the treatment of phlebitis caused by venous indwelling needle. Methods:96 cases with phlebitis caused by venous indwelling needle were randomly divided into the experimental group and the control group with 48 cases in each.The experimental group were treated with topical hirudoid ointment combined with appropriate massage,while the control group were treated with the local wet dressing with saturated magnesium sulfate solution. We compared two groups with local skin red and(or) tumor regression time,the effect of treatment of phlebitis.Results:In the experimental group,the local skin red and(or) tumor regression time was 12±4.8 hours,and total efficiency was 98%.In the control group,the local skin red and(or) tumor regression time was 24.0±4.2 hours,and total efficiency was 91.7%.There were statistically significant differences between the two groups(P<0.05).In the experimental group,the local skin red and(or) tumor regression time was shorter than that of the control group,and the treatment effect was better than that of the control group.Conclusion:The application of topical hirudoid ointment combined with appropriate massage in the treatment of phlebitis caused by venous indwelling needle has many advantages,for example,the treatment effect is good,the local skin red and(or) tumor regression time is fastest,moreover,materials of the hirudoid ointment is convenient,the use is simple,the effect is easy to observe,and the use is safe and efficient.%目的:探讨喜疗妥软膏治疗静脉留置针输液致静脉炎的效果。方法:将96例使用静脉留置针输液致静脉炎的患者随机分为试验组和对照组各48例,试验组采用局部外涂喜疗妥软膏结合适当按摩患处的方法,对照组采用饱和硫酸镁溶液局部湿敷患处的传统方法。比较两组患者局部皮肤红和(或)肿消退时间长短、静脉炎的治疗效果。结果:试验组

  4. 散结乳癖膏治疗卵巢囊肿模型大鼠的实验研究%Experimental Study of Sanjierupi Ointment for Ovarian Cyst Model Rats

    Institute of Scientific and Technical Information of China (English)

    侯惠玲; 靳瑾健; 关宏; 郭皓

    2016-01-01

    目的:通过观察散结乳癖膏治疗卵巢囊肿模型大鼠在治疗前后血清中促黄体生成素及促卵泡刺激素含量,客观评价其治疗卵巢囊肿的疗效,为中医药治疗卵巢囊肿提供实验依据。方法:选取雌性未孕大鼠64只,采取手术的方法造模,从中选取造模成功大鼠,外敷散结乳癖膏(高、中、低剂量),连续6周,处死大鼠,观察移植物外观测量,取血后用放射免疫法检测大鼠体内促黄体生成素及促卵泡刺激素的含量。结果:散结乳癖膏可使模型大鼠的卵巢体积缩小,同时,散结乳癖膏高、中、低剂量组促黄体生成素及促卵泡刺激素含量与模型组比较,差异均有统计学意义(P<0.05),结论:散结乳癖膏可降低大鼠血清中促黄体生成素及促卵泡刺激素的含量,对卵巢囊肿大鼠有一定的治疗作用,为今后临床用药提供新的思路。%Objective:To evaluate the effects of Sanjierupi Ointment on ovariancyst in serum model rat by observing the content of luteinizing hormone and follicle-stimulating hormone before and after the treatment,in order to provide experimental basis.Method:The female unfertilized 64 rats were taken,using the surgical method to select the successful model rats.The building successful rats were selected and topical application of Sanjierupi Ointment in abdominal(high,middle and low doses),after 6 weeks,put to death in the rat,the execution of the grafts was observed and taken blood from eyes to detect LH and FSH by radioimmunoassav.Result:Sanjierupi Ointment reduced the model rat ovarian volume.At the same time,the content of LH and FSH of the high,middle and low doses group compared with the model control group,there had significant differences(P<0.05). Conclusion:Sanjierupi Ointment can reduce the content of LH and FSH,it has certain treatment function for ovarian cyst,and it can provide new ideas for future clinical treatment.

  5. Determination of the content of glucosamine hydrochloride in glucosamine hydrochloride ointment by pre-column derivatization RP-HPLC%柱前衍生化法测定盐酸氨基葡萄糖软膏的含量

    Institute of Scientific and Technical Information of China (English)

    廖栩; 王淑君; 佟岩; 李迅; 蒋艳霞; 刘洪兵

    2011-01-01

    目的 建立柱前衍生化RP-HPLC法测定盐酸氨基葡萄糖软膏的含量.方法 采用NH2色谱柱(250mm×4.6 mm,5 μm),流动相为乙腈-水(体积比90:10),流速为1.0 mL·min-1,衍生化试剂为异硫氰酸苯酯,检测波长254 nm.结果 在本色谱条件下,盐酸氨基葡萄糖质量浓度在12.75~38.25 mg·L-1内呈良好的线性关系,回收率为100.4%.结论 该方法准确、可靠,适用于盐酸氨基葡萄糖软膏的含量测定.%Objective To establish a pre-column derivatization RP-HPLC method to determine the glucosamine hydrochloric in glucosamine hydrochloric ointment. Methods RP-HPLC was adopted with an NH2column(250 mm x 4.6 mm,5 μm), a mobile phase consisting of acetonitrile-water (V: V = 90: 10), at 1.0 mL·min-1. The UV detective wavelength was set at 254 nm. Results Glucosamine hydrochloric was well separated. The method showed a good linearity for glucosamine hydrochloric in range of 12. 75-38.25 mg· L - 1 ( r = 0.999 3 ). The average recovery was 100. 4%. Conclusions The method can be used to determine glucosamine hydrochloric in glucosamine hydrochloric ointment.

  6. Tolerability and effects on quality of life of liposomal nasal spray treatment compared to nasal ointment containing dexpanthenol or isotonic NaCl spray in patients with rhinitis sicca.

    Science.gov (United States)

    Hahn, C; Böhm, M; Allekotte, S; Mösges, R

    2013-09-01

    This study aimed to investigate symptom reduction via the liposomal nasal spray LipoNasal (LN) in patients with rhinitis sicca. Tolerability and the impact on quality of life were also examined. The same parameters were established in parallel for treatment approaches with Bepanthen (BP) nasal ointment containing dexpanthenol and the Rhinomer (RH) nasal spray containing NaCl. This prospective, controlled, open-label observation study was a multicenter trial. 92 patients with rhinitis sicca were allocated to three arms according to their symptoms: LN: n = 33; BP: n = 32 and RH: n = 27. The study comprised three visits at an interval of 14 days. Efficacy was examined by the Rhinitis Sicca Symptom Score (RSSS) documented daily and at the visits based on an endoscopic evaluation. The nasal spray sensory scale was used to investigate the tolerability. Quality of life (QoL) was measured by means of the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) and the "Short Form 12" of the "Impact on Health-Related Quality of Life (HRQL)" questionnaire on general quality of life. Nasal symptoms improved significantly (p = 0.001) under all three treatment approaches, reflected by the reduction in the RSSS and the Endoscopy Sum Score. A comparison of the three groups showed that no therapy was significantly superior to any of the others (p = 0.410). The tolerability of all treatments was good. Concerning the nasal moisturization, LipoNasal was evaluated better than Bepanthen and Rhinomer. Quality of life improved in all groups, but not significantly. The results show good efficacy and tolerability of the liposomal nasal spray compared to generally recognized treatments of rhinitis sicca with dexpanthenol nasal ointment and NaCl nasal spray. LipoNasal therefore constitutes a good treatment for patients suffering from dry nose.

  7. Effect of Homemade Chilblain Ointment on Hair Growth of Frostbite Rabbits%自制冻疮软膏对兔冻伤后毛发的促生长作用

    Institute of Scientific and Technical Information of China (English)

    刘璟; 修彬华; 曾平; 张莉; 尹东锋; 周军

    2012-01-01

    Objective To establish a model of frostbite rabbits and observe the effect of homemade chilblain ointment on frostbite rabbits'hair growth. Methods Twenty rabbits were equally randomized into the control and treatment group. Models of grade Ⅱ were prepared using the liquid nitrogen after hair removal. Skin was taken at different time, fixed by formalin, paraffin embedding, slice, and stained by conventional hematoxylin-eosin. Pathological analysis was observed after fixing. Results During the treatment, the pathology of the hair follicle was different between the treatment group and control group. Conclusion Homemade chilblain ointment has certain curative effect on the hair growth of frostbite rabbit.%目的 建立兔冻伤模型,观察自制冻疮软膏对兔冻伤后毛发的促生长作用.方法 选择普通新西兰大白兔20只,对照组、实验组各10只.备皮,脱毛,经液氮致深Ⅱ度冻伤后进行动物治疗实验,在不同时间取皮,经福尔马林固定,石蜡包埋,切片,常规苏木精-伊红染色,封片固定,观察分析病理切片.结果 对照组和实验组比较,毛发生长情况有明显差别.结论 自制冻疮软膏对冻伤后毛发生长有一定的疗效.

  8. Evaluation of the effect of radiation sterilization process on the clinical efficacy of Shengji ointment%辐射灭菌法对生肌膏临床疗效影响的评价

    Institute of Scientific and Technical Information of China (English)

    冯鑫; 房德敏; 武秀梅; 王殿荣; 崔春淼; 黄艳萍

    2015-01-01

    目的:观察60 Co‐γ辐射灭菌法对生肌膏临床疗效的影响,以提高创面修复质量。方法选择2013年3月-2014年3月医院收治的符合纳入标准患者进行随机对照研究,治疗组33例患者应用灭菌生肌膏,对照组32例患者应用普通生肌膏;两组患者分别于入组后的第0、3、6、9、12、15天观察伤口愈合情况,并对创面形态、创面肉芽、创面分泌物、创面pH值和分泌物细菌培养及创面周围肿胀程度、疼痛程度、皮肤温度等进行评分并记录,最后进行统计评价。结果在治疗第15天后两组患者总有效率均为100.0%;在伤口愈合率、肉芽生长、创面pH、水肿评分、疼痛评分、皮肤温度等疗效相当;第9天比较两组对感染的治疗与控制疗效相当,但是创面形态修复对照组比治疗组早3 d发生明显改变;对照组脓液增加明显,第9天有显著增加( P=0.030),治疗组脓液变化不明显。结论采用60 Co‐γ射线辐射灭菌的方法对生肌膏进行灭菌处理后,对生肌膏的总体临床疗效影响较低,而且未经过灭菌处理的生肌膏也未见有加重创面感染的现象。%OBJECTIVE To investigate the effect of 60 Co‐ gamma radiation sterilization on the clinical efficacy of Shengji ointment so as to improve the quality of wound repair .METHODS Patients admitted in Mar .2013 to Mar . 2014 that met the inclusion criteria were enrolled in this randomized controlled study .The treatment group (n=33) received sterile Shengji ointment ,while the control group (n= 32) received normal Shengji ointment .The wound healing situation in the two groups was observed at 0 ,3 ,6 ,9 ,12 ,15 days after grouping .The wound morphology ,granulation ,secretion ,bacterial culture ,pH of wound surface ,degree of swelling and pain around the wound and skin temperature were scored and recorded . Finally the statistical evaluation was evaluated . RESULTS The total

  9. Study on absorption and accumulation of mercury in rats by repeated administration of Yuhong ointment%玉红膏重复给药大鼠体内汞的吸收及蓄积研究

    Institute of Scientific and Technical Information of China (English)

    邱恒; 孙新民; 黄雯; 胡小靖; 王旗; 牟稷征; 王丽霞

    2013-01-01

    Objective:To study in vivo mercury absorption and accumulation through repeated transdermal administration of Yuhong ointment containing calomel,in order to provide scientific evidences for clinical safe medication.Method:A total of 100 SD rats were randomly classified into five groups:the control group,the Yuhong ointment group,the double-concentration Yuhong Ointment group,the quadruple-concentration Yuhong ointment group and the 1.6% calomel group.The rats were treated with the dosage of 0.04 g · cm-2 by repeated transdermal administration for 2,4 weeks.After the drug discontinuance for 4 weeks,the levels of mercury in blood,urine,and tissues of heart,liver,brain and kidney were determined,respectively.Result:Compared with the control group,the blood mercury level of the Yuhong ointment group show no obvious change after treatment for 4 weeks.However,the levels of mercury in blood and urine of other experimental groups increased significantly with time and the increase in dosage,and so did the level of mercury in major organ.At 4 weeks,all experimental groups showed increase in the content of mercury,and kidneys displayed the highest level,whereas brain displayed the lowest level.After the drug discontinuance for 4 weeks,the mercury level in blood and urine of every dose group recovered to normal,with significant decline in the content of mercury in each organ.Conclusion:After transdermal administration in rats for 4 weeks,there was no obvious absorption of mercury in blood.Mercury was mainly accumulated in kidneys and excreted through urine.The results suggest that the patients' mercury content and kidney function indexes need to be monitored in long-term clinical use of Yuhong ointment.%目的:通过经皮重复给予大鼠不同浓度含轻粉玉红膏,考察体内汞的吸收及蓄积情况,为临床安全用药提供科学依据.方法:将100只SD大鼠随机分成5组:对照组、玉红膏组、2倍浓度玉红膏组、4倍浓度玉红膏组和1.6%

  10. 黑布药膏对兔耳增生性瘢痕成纤维细胞增殖与凋亡的影响%Effect of Heibu Ointment on Proliferative Activity and Apoptosis of Fibroblats in Hypertrophic Scarring Model in Rabbit Ears

    Institute of Scientific and Technical Information of China (English)

    赵丽; 王莹; 关洪全

    2011-01-01

    Objective:To investigate the effect of Heibu Ointment on proliferative activity and apoptosis of fibroblasts in the hypetrrophic scarring model in rabbit ears. Method: Twenty-four white rabbits were used to establish the model of hypertrophic scar in ears. After twenty-one days, the model rabbits were randomly divided into Heibu Ointment treatment group and model group. In Heibu Ointment treatment group, Heibu Ointment was plastered on the hypetrrophic scars once in every three days. The treatment course lasted for fifty-six days. The scar tissue was sampled on the second, the fourth, the sixth and the eighth week for the two groups. The changes in fibroblasts treated with Heibu Ointment were compared with that of the controls during the forming of hypertrophic scars. The expression of proliferation cell nuclear antigen (PCNA) was measured by immunohistochemistry technique, and the apoptosis was measured by TUNEL. Result: The expression of PCNA in the Heibu Ointment treatment group was obviously weaker than that of the controls ( P < 0.05 ), and the apoptosis was increased in Heibu Ointment treatment group (P < 0. 05 ). Conclusion: Heibu Ointment can inhibit the proliferation of fibroblasts and accelerate cell apoptosis in hypertrophic scars in rabbit ears.%目的:探讨黑布药膏对兔耳增生性瘢痕成纤维细胞增殖与凋亡的影响.方法:成年大耳白兔24只,建立兔耳增生性瘢痕动物模型,21 d后,将瘢痕动物模型随机分为黑布药膏治疗组和瘢痕模型组,在黑布药膏治疗组瘢痕局部涂抹黑布药膏,每3 d 1次,连续用药56 d.在用药第2,4,6,8周分别切取两组瘢痕组织,对比研究在瘢痕形成过程中黑布药膏对兔耳瘢痕成纤维细胞的影响,采用免疫组化方法检测增殖细胞核抗原(PCNA)蛋白表达和细胞凋亡的原位检测.结果:按不同时间段取材进行免疫组化染色,高倍镜下观察,结果显示:黑布药膏治疗组和模型对照组比

  11. Moist Exposed Burn Ointment in the Management of Burn Wound%湿润烧伤膏在烧伤创面治疗中的作用

    Institute of Scientific and Technical Information of China (English)

    V·贾亚拉曼

    2012-01-01

      Management of burns remains one of the greatest challenges in burn care. Local management of a burn wound requires early wound debridement and an optimum environment to stimulate epithelialisation and cellular prolifera-tion. Protocol was developed as early as 30 years ago for the management of burns that includes early excision and SSG cov-erage. The results were not perfect. The quality of healed skin as well as the prominence of hypertrophic scar needs to ex-plore the novel approaches. Wound healing assessment was made in burn wounds in 100 patients treated with MEBO cream and in 100 patients with Silver Sulpha Diazine Cream at the Kilpauk Medical College Hospital, Burns Unit. The comparative analysis is presented to assess the wound healing pattern in both the groups. Moist exposed burn ointment has been used with success in the management of deep superficial partial thickness and deep partial thickness burns in our department. The MEBO cream creates a physiological moist environment over the wound inducing an anti-inflammatory effect. It provides a nutritive base for the wound and debrides the wound eschar and expedites wound epithelialisation. The purpose of this study was to prospectively evaluate the outcome of the use of MEBO for second degree burns. Between August 2010 to May 2011 period 100 patients with second degree burns underwent MEBO cream application and were compared with 100 patients who had silver sulphadiazine cream . The result was analysed for the nature of wound debridement, reduction of inflammation, healing pattern, scar and pigmentation, MEBO provides excellent skin pigmentation and minimal visible scar.%  烧伤治疗一直是烧伤领域中的一大难题.烧伤创面的局部治疗要求早期清创,并为创面提供一个适宜的环境刺激上皮形成和细胞的分化.早在30年前,烧伤的标准化治疗方案就已经形成,包括早期切痂及韧厚皮移植,但治疗效果不尽人意.为了改善愈合后的皮

  12. Observation of the curative effect of liquid nitrogen cryotherapy combined with compound flumetasone ointment in the treatment of localized chronic haplolichen%液氮冷冻联合复方氟米松软膏治疗局限性慢性单纯性苔癣的疗效观察

    Institute of Scientific and Technical Information of China (English)

    杨艳萍; 罗瑞

    2015-01-01

    Objective:To explore the curative effect and safety of liquid nitrogen cryotherapy combined with compound flumetasone ointment in the treatment of localized chronic haplolichen.Methods:68 patients with localized chronic haplolichen were selected.They were randomly divided into the experimental group and the control group with 34 cases in each group.The experimental group was treated with liquid nitrogen cryotherapy combined with compound flumetasone ointment,and the control group was treated with compound flumetasone ointment,then we compared the therapeutic effect of the two groups.Results:The effective rate of 88.2% in the experimental group was significantly higher than 64.7% of the control group(P<0.05).Conclusion:The curative effect of liquid nitrogen cryotherapy combined with compound flumetasone ointment in the treatment of localized chronic haplolichen was significant,and security was high.%目的:探讨液氮冷冻联合复方氟米松软膏外擦治疗局限性慢性单纯性苔癣的疗效及安全性.方法:收治局限性慢性单纯性苔癣患者68例,随机分为试验组和对照组各34例,试验组采用液氮冷冻联合复方氟米松软膏治疗,对照组采用复方氟米松软膏治疗,比较两组治疗效果.结果:试验组有效率88.2%明显高于对照组的64.7%(P<0.05).结论:液氮冷冻联合复方氟米松软膏治疗局限性慢性单纯性苔癣疗效显著,安全性高.

  13. Clinical Observation of 105 Cases of Fumigation with Chronic Hand Eczema Wudai Ointment in the Treatment of Traditional Chinese Medicine%中药熏洗联合蜈黛软膏治疗手部慢性湿疹105例临床观察

    Institute of Scientific and Technical Information of China (English)

    石孟轩; 朱芮弘

    2016-01-01

    Objective To observe effects of Chinese Fumigation and washing plus the Wudai ointment in the treatment of chronic eczema efficacy . Methods Selected 105 cases of hand chronic eczema patients according to the random number table method were divided into treatment group, control group, treatment group were treated by traditional Chinese medicine fumigation again Waicha Wudai ointment and packet 1H, and the control group were treated with compound ketoconazole ointment, efficacy were compared between the two groups. Results In the treatment group, the effective rate was 89.09%, control group, the effective rate was 64.00%, the difference was significant (P< 0.05). Conclusion The Chinese medicine fumigation washing combined with the Wudai ointment in the treatment of hand of chronic eczema is effective.%目的:观察中药熏洗联合蜈黛软膏治疗手部慢性湿疹的疗效。方法将入选的105例手部慢性湿疹患者按随机数字表法分为治疗组、对照组,治疗组予中药熏洗后再外搽蜈黛软膏并封包1 h,对照组外用复方酮康唑软膏,对比两组疗效。结果治疗组有效率89.09%,对照组有效率64.00%,差异显著(P<0.05)。结论中药熏洗联合蜈黛软膏治疗手部慢性湿疹有效。

  14. Fisico with Hirudoid ointment in hemodialysis patients with dynamic protection effect of intravenous fistula%非热康谱联合喜疗妥在血液透析患者动静脉内瘘护理中的应用

    Institute of Scientific and Technical Information of China (English)

    丁晓仙; 樊玲燕

    2016-01-01

    Objective:Study Fisico with Hirudoid ointment internal fistula in hemodialysis patients protection function. Method:54 cases of long-term hemodialysis patients were randomly divided into controlgroup and observation group ,27 cases in each group .The control group using hot compress combined with Hirudoid ointent, the observation group using Fisico Hirudoid ointment .Two groups of patients after 12 months of treatment. Result:After 12 months of treatment the patients in observation group were better that the control group in improving blood flow .Tdifference between the two groups was significant. Conclusion:Autologous arteriovenous fistula in hemodialysis nursing ,non thermal ointment,hot compress with Hirudoid ointment.%目的:探讨非热康谱联合喜疗妥在血液透析患者动静脉内瘘护理中的作用。方法:将54例自体动静脉内瘘患者分为对照组和观察组,每组27例,对照组采用热敷联合喜疗妥软膏外涂,观察组采用非热康谱联合喜疗妥。比较两组治疗12个月之后的血管情况。结果:观察组在改善内瘘血管弹性、提高血流量等方面均优于对照组,两组比较差异显著(P<0.05)。结论:血液透析患者自体动静脉内瘘护理中,非热康谱联合喜疗妥,效果优于热敷联合喜疗妥。

  15. 对《中国药典》2010年版磺胺嘧啶锌软膏鉴别试验的探讨%The Discussion on Identification Test of Sulfadiazine Zinc Ointment in Chinese Pharmacopoe-ia (2010 Edition)

    Institute of Scientific and Technical Information of China (English)

    杨淑先; 李少杰

    2014-01-01

    Objective:To improve the identification test of sulfadiazine zinc ointment in Chinese Pharmacopoeia ( 2010 Edi-tion).Methods: Increasing the sample quantity in the process of potassium ferrocyanide precipitation reaction to filtrate en-richment precipitation and reducing the amount of hydrochloric acid to reduce the total volume of the final solution and to make for the precipitation and enrichment.Results: The improved method can be used to identify sulfadiazine zinc ointment with a high specificity and effectiveness.Conclusion: The improved test method can be listed in the identification test in the sulfadi-azine zinc ointment.%目的:改进《中国药典》2010年版磺胺嘧啶锌软膏鉴别试验方法。方法:增加参与亚铁氰化钾沉淀反应的样品量,可滤过富集沉淀以进行后续的鉴别试验;减少盐酸用量,从而减少最终溶液总体积,更利于沉淀析出和富集。结果:改进后的方法可以专属而有效地鉴别磺胺嘧啶锌软膏。结论:改进后的试验方法可以用于磺胺嘧啶锌软膏的鉴别试验。

  16. 0.03%他克莫司软膏治疗口腔糜烂型扁平苔藓的疗效观察%Observation of Therapeutic Effect of 0.03 %Tacrolimus Ointment on Patients with Erosive Oral Lichen Planus

    Institute of Scientific and Technical Information of China (English)

    祝磊; 焦静

    2012-01-01

    Objective: To investigate the effects of 0. 03% Tacrolimus ointment on patients with erosive oral lichen planus. Methods: A total of 67 cases were collected and divided into two groups randomly: 33 cases were treated with 0.03% Tacrolimus ointment (treatment group), and 30 cases with Triamcinolone acetonide and retinoic acid (control group). Results: There was significant difference between two groups of the effective rate and side-effect occurrence during the therapy within six months after treatment. Conclusion: The results of the present work demonstrate that 0. 03% Tacrolimus ointment is an effective therapy for erosive oral lichen planus.%目的:观察局部应用0.03%他克莫司软膏治疗口腔糜烂型扁平苔藓的疗效.方法:选择口腔糜烂型扁平苔藓患者67例并随机分成两组,分别用0.03%他克莫司软膏和局部注射曲安奈德联合维甲酸治疗.结果:随访观察治疗6个月后显效率及不良反应率,两组差异显著.结论:0.03%他克莫司软膏治疗口腔糜烂型扁平苔藓具有良好的临床疗效.

  17. 金霉素眼膏对胃肠减压患者鼻咽舒适度的影响%The Effect of Chlortetracycline Eye Ointment on Nasopharyngeal Comfort of Patients with Gastrointestinal Decompression

    Institute of Scientific and Technical Information of China (English)

    张锦莲; 张柳华; 杨璐晖; 曾芝云

    2014-01-01

    Objective:To investigate the effect of chlorotetracycline eye ointment on nasopharyngeal comfort of patients with gastroenteric decompression.Method:182 patients with indwelling gastrointestinal decompression tube in our department from July 2012 to October 2013 were selected,they were divided into the control group for 90 cases and the intervention group for 92 cases according to the random number table method.The control group was treated with routine requirements including oral care,gargling with collutory,blowing the nasal with normal saline cotton stick,while the intervention group was treated with chlorotetracycline eye ointment in the local administration of a gastric tube side nasal cavity.The degree of comfort of pars nasalis pharyngis and the acceptance of stomach tube of two groups were compared. Result:The nasopharyngeal discomfort incidence of intervention group was 67.40%(62/92),it was significantly lower than 96.67%(87/90)of control group,the acceptance of stomach tube in intervention group was significantly higher than the control group,the differences were statistically significant(P<0.01).Conclusion:Topically treatment of chlorotetracycline eye ointment to patients with gastroenteric decompression can reduce the discomfort of pars nasalis pharyngis,increase the patients’acceptance of the stomach tube,improve degree of comfort and compliance of treatment,is worthy of clinical promotion.%目的:探讨金霉素眼膏鼻腔局部用药对胃肠减压患者鼻咽部舒适度的影响。方法:选取2012年7月-2013年10月本科留置胃肠减压管的182例患者,按照随机数字表法将其分为对照组90例和干预组92例。对照组按常规要求进行口腔护理、漱口液漱口、生理盐水棉签清洁鼻腔;干预组在对照组的基础上使用金霉素眼膏在插胃管侧鼻腔局部用药。比较两组患者鼻咽部舒适度及患者对胃管的接受程度。结果:干预组的鼻咽部不适发生率67.40%(62

  18. 祛痛膏对椎动脉型颈椎病祛痛的临床疗效分析%A clinical analysis of treating vertebral artery type of cervical spondylosis with the Qutong ointment

    Institute of Scientific and Technical Information of China (English)

    韩福祥; 秘兴锋; 司俊梅; 李清云; 田秀华; 李忠伟; 赵雪艳; 赵广声

    2014-01-01

    Objective: To study clinical efficacy of the Qutong ointment on vertebral artery type of cervical spondylosis. Methods: 60 patients with vertebral artery type of cervical spondylosis, according to the odd and even number method, were randomly divided into control group and observation group, 30 cases respectively. The control group was given the Jingfukang granule, the observation group was treated by the Qutong ointment. Clinical effects and symptoms were compared in both. Results: The total efficacy in the control (66.67%) was obviously lower than that in the observation (93.33%). The difference was statistically significant (P<0.05). Symptomatic rates of vertigo, discomfort in neck, headache, blurred vision, fatigue, amnesia, instability of gait, purple tongue, white tongue fur and deep thready pulse were observed in both, the difference was statistically significant (P<0.05). Conclusion: The Qutong ointment was effective on vertical artery type of cervical spondylosis, showed lower symptomatic rate, and was worthy of clinical recommending.%目的:探讨祛痛膏对椎动脉型颈椎病祛痛的临床疗效。方法:将60例椎动脉型颈椎病患者按照奇偶数字法随机地均分为对照组与观察组,各30例。对照组口服颈复康颗粒治疗,观察组则采用自制祛痛膏治疗。比较两组临床治疗效果及治疗前后症状发生率。结果:对照组临床治疗总有效率为66.67%,显著低于观察组(93.33%)(P<0.05);两组治疗前后眩晕、颈部不适、头痛、视物模糊、倦怠乏力、健忘、步态不稳、舌暗、舌苔白及脉沉细等症状发生率差异均具有统计学意义(P<0.05~0.01),且观察组治疗后上述症状发生率均显著低于对照组治疗后(P<0.05)。结论:祛痛膏对椎动脉型颈椎病祛痛的临床疗效显著,且临床症状发生率也显著降低,值得在临床上加以推广及应用。

  19. 盐酸米诺环素对慢性牙周炎基质金属蛋白酶-8水平的影响%Effect of Minocycline Hydrochloride Ointment on MMP-8 in Gingival Crevicular Fluid Abstract

    Institute of Scientific and Technical Information of China (English)

    井枫秋; 汪黎明; 张洁; 黄云亮

    2011-01-01

    目的 研究盐酸米诺环素对慢性牙周炎患者龈沟液中基质金属蛋白酶-8(matrix metalloproteinase-8,MMP-8)水平的影响.方法 选26例中重度慢性成人牙周炎患者,每例口腔左右两个象限随机分为实验组和对照组.基础治疗后实验组使用盐酸米诺环素缓释软膏,每周1次,共2次.对照组不使用盐酸米诺环素软膏,仅使用生理盐水和10%过氧化氢冲洗.使用酶联免疫法(ELISA)测定两组治疗前后龈沟液中基质金属蛋白酶-8的水平.结果 实验组、对照组在基础治疗后龈沟液中基质金属蛋白酶-8总量和浓度均明显降低(P<0.01).实验组与对照组龈沟液中基质金属蛋白酶-8总量和浓度的变化差异有统计学意义,实验组基质金属蛋白酶-8总量和浓度减少的量要多于对照组(P<0.01).结论 基础治疗和盐酸米诺环素缓释软膏联合应用能有效降低慢性牙周炎患者龈沟液中基质金属蛋白酶-8水平,改善牙周状况.%Objective To analyze the changes of matrix metalloproteinases - 8 ( MMP - 8) levels in gingival crevicular fluid (GCF) after subgingivally administering 2% minocycline - HCl ointment to the periodontal pocket as an auxiliary treatment of moderate and severe chronic periodontitis. Methods Twenty - six subjects were selected. The left and right sides of oral cavity were divided into control group and test group with a randomized single blind method. After initial periodontal treatment of both groups, the test group was treated with the sustained release unguent of minocycline - HCL ointment in the pocket once a week for 2 weeks,while the control group with 0.9 % normal saline and 10% hydrogen peroxide. Two weeks later, gingival crevicular fluid samples were collected and detected with ELISA technique. Results The level of MMP - 8 in GCF obviously declined after treatment in both groups( P <0.01 ), particularly in the test group. The difference was statistically sigificant(P < 0. 01

  20. 立奇膏联合百克瑞治疗糖尿病足的临床研究%Clinical study on Bactericide soaked gauze combined with Liqi ointment for treatment of patients with diabetic foot

    Institute of Scientific and Technical Information of China (English)

    赵志芳; 张敏; 朱月珍

    2015-01-01

    Objective:To explore the nursing effect of self made Liqi ointment combined with bactericide soaked gauze for treatment of patients with diabetic foot ulcer.Methods:A total of 80 patients with 2~4 level diabetic foot ulcer from out patient clinic and in patients were selected and randomly divided into treatment group and control group,40 cases in each.On the basis of same comprehensive treatment,the patients in control group were trea-ted only with bactericide soaked gauze for wound treatment and the patients in treatment group were com-pressed with self made Li Qi Ointment after wet compressing with bactericide soaked gauze.The differences of total effective rate were compared after intervention.Results:After 12 weeks of intervention,the wound area in treatment group patients was reduced,and the painful feeling in dressing was relieved and then the fasting glu-cose of patients was basically reduced to the normal range.The total effective rate of 95.0%,which was signifi-cantly higher than that in control group(P <0.05).Conclusion:The self made Li Qi ointment combined with bactericide soaked gauze has significantly effect for patients with 2~4 grade diabetic foot ulcer,and it is an ef-fective,safe and economic method.%[目的]探索采用自制中药“立奇膏”联合百克瑞纱布治疗糖尿病足溃疡的护理效果。[方法]选择门急诊及住院2级~4级糖尿病足溃疡病人80例,随机分为治疗组和对照组各40例,在相同综合治疗基础上,对照组常规选用百克瑞纱布湿敷进行伤口处理;治疗组百克瑞纱布湿敷后外敷自制中药“立奇膏”进行伤口处理,干预结束后比较两组总有效率。[结果]干预12周后,治疗组创面面积缩小,换药时疼痛感减轻,空腹血糖基本降至正常范围,总有效率达95.0%,明显优于对照组,两组比较差异具有统计学意义(P <0.05)。[结论]自制中药“立奇膏”联合百克瑞纱布湿敷治疗2级~4级糖尿病足

  1. 金黄超微透皮软膏对奶牛乳房炎的治疗效果观察%Treatment Effects of Jinhuang Superifne-transdermal Ointment on Cow Mastitis

    Institute of Scientific and Technical Information of China (English)

    曹立辉; 陈公武; 郭朝文

    2016-01-01

    In order to investigate the treatment effects of Jinhuang Superfine-transdermal Ointment on cow mastitis, thirty recessive mastitis cows and twenty-five clinical mastitis cows were randomly divided into two groups. Forty-ifve udder regions of iffteen recessive mastitis cows were assigned into experiment group and forty-two udder regions of the others as control group. Twenty-ifve udder regions of iffteen clinical mantitis cows were assigned into experiment group and iffteen udder regions of the other ten cows as control group. The experiment group were smeared ointment two times per day for 3-5 consecutive days. Cells in milk were detected which were collected from recessive mastitis cows everyday, while the clinical mastitis cows were detected from appearance, touch feelings, milk condition and CMT to judge the treatment. The results indicated that after recessive mastitis cows accepted treatment with 3 days,the effective rate was 100% and cure rate was 89.58%, while the control group without treatment had no one recovery. when the clinical mastitis cows were smeared with 5 days, detected after stopping treatment for a week.The results showed the four indexes tested from the cows of the experiment group were recovered to normal,which had a 80% recovery. While the control group neither reach cure level. The experiment suggested that Jinhuang Superfine-transdermal Ointment has a good therapeutic effect on recessive mastitis and clinical mastitis.%为了探讨金黄超微透皮软膏对奶牛乳房炎的治疗效果,将30头隐性乳房炎患牛和25头临床型乳房炎患牛分别各自随机分为2组。其中,隐性乳房炎患牛中的15头48个乳区为试验组,另15头42个乳区为对照组;临床型乳房炎患牛中的15头25个乳区为试验组,另10头15个乳区为对照组。试验组奶牛每天涂抹受试金黄超微透皮软膏2次,连用3~5d;对照组不用药。每天采集隐性乳房炎患牛奶样,测定其体细胞数变化

  2. 0.1%他克莫司软膏治疗成年人面部敏感性皮肤的疗效和观察%Efficacy and safety of tacrolimus ointment for facial sensitive skin in adults

    Institute of Scientific and Technical Information of China (English)

    曹源; 谢志强; 张春雷

    2016-01-01

    目的:观察0.1%的他克莫司软膏治疗成年人面部敏感性皮肤的疗效和安全性。方法给予36例诊断为敏感性皮肤的患者外用0.1%他克莫司软膏,每日2次,共3周,如果用药不到3周痊愈,可停止用药。于治疗前及治疗后1、3周和停药后4周各随访1次,评估病情严重程度及临床疗效。采用皮肤病生活质量调查问卷评估敏感性皮肤对生活质量的影响。结果36例患者中32例完成临床试验。治疗3周后皮炎症状的临床痊愈率、显效率分别为46.9%、40.6%,有效率为87.5%。治疗3周后10项评估指标及生活质量均有明显改善(P <0.001)。主观症状改善最明显的是自觉干燥、针刺感。客观症状中脱屑、干燥症状对治疗的反应最好。药物不良反应发生率为72.2%(瘙痒占30.8%,烧灼感占69.2%,刺痛占7.7%),其中有50%只出现于用药后2d 内。结论0.1%他克莫司软膏治疗成年人面部敏感性皮肤安全、有效,刺激反应较普遍,多为一过性,可耐受。%Objective To investigate the clinical efficacy and safety of topical 0.1% tacrolimus ointment in the treatment of adults patient with facial sensitive skin. Methods Total 36 cases were treated with topical 0.1% tacrolimus ointment, twice daily, and the clinical symptom and sign scores were recorded before and after the treatment. A new scale, which including 6 subjective skin conditions (pricking, burning sensation, itching, pain, dry sensation, tightness) and 4 visible skin conditions (erythema, swelling, scaling, dryness) was adopted for assessment at the baseline and succeeding improvement of skin condition. Dermatology life quality index was used to evaluate the impact of sensitive skin on life quality. Meanwhile the adverse events were observed. Results Thirty-two of the 36 cases completed the whole course of treatment. The cure rate was 46.9%(15/32), markedly improvement rate was 40.6%(13/32), moderate

  3. Therapeutic effects of Jingwanhong ointment (京万红软膏)on healing of chronic diabetic wound in mice%京万红软膏治疗糖尿病慢性创面的实验研究

    Institute of Scientific and Technical Information of China (English)

    姜玉峰; 黄沙; 邹吉平; 许樟荣; 高虹; 付小兵

    2013-01-01

    Objective: To explore the promoting effect of Jingwanhong ointment ( 京万红软膏 ) in healing of chronic open wound and its mechanism in diabetic mice. Methods: Fifty-four clean-grade male C57 mice were randomly divided into Jingwanhong ointment group, compound sulfadiazine zinc gel group (medicine control group) and blank control group (n = 18). The model of diabetes was replicated by consecutive administration of 1 % strep-tozotocin intraperitoneally 60 mg/kg for 3 days. Then, on the back of mice, round full-thickness skin wounds with diameter of 1 cm were produced. Jingwanhong ointment or compound sulfadiazine zinc gel was applied on the wounds of the two medicine treatment groups after the second day of wound formation, and vaseline gauze was applied on all the wounds of the three groups. Dressing-change was done daily. On the 3rd, 7th, 10th, 17th, 21st days after treatment, the circumference of the wounds was drawn on transparent plastic films for the estimation of the rate of wound healing. On 7th and 17th day after treatment, 3 mice of every group were sacrificed respectively, and gross morphological changes,histopathological changes in skin and granulation tissue within 2 mm of edge of the wounds were examined. Results:The wound healing rate of the two treatment groups increased on the 7th day after treatment, but the difference was not significant among the three groups (P>0. 05). On the 10th, 17th, 21st day after treatment, the wound healing rate in medicine control group [(81. 00 ± 0. 85) % , (95. 00 ± 0. 29) % , (97.00 ± 0.37)% ] was significantly higher than those of the blank control group [(77. 00 ±1. 35) % ,(87. 00 ± 1. 17)% , (90. 00 ± 0. 96)%,P0.05).给药后10、17和21 d,对照药物组创面愈合率[(81.00±0.85)%,(95.00±0.29)%,(97.00±0.37)% ]明显高于空白对照组[(77.00±1.35)%,(87.00±1.17)%,(90.00±0.96)%,P<0.05],而京万红软膏组愈合率[(85.00±1.93)%,(100.00±0)%,(100.00±0)% ]明显高于对照药物组(P<0.05).

  4. 玉红膏单次给药家兔体内汞的吸收及毒性%Mercury Absorption and Toxicity of Single Dose of Yuhong Ointment in Rabbits

    Institute of Scientific and Technical Information of China (English)

    孙新民; 王旗; 牟稷征; 王丽霞

    2011-01-01

    Objective; To study the toxicity and absorption of mercury following single dose transdermal administration of Yuhong ointment containing 0.4% calomel in rabbits. Method; Twelve Japanese white rabbits, half in male or female, were divided into three groups; control group, Yuhong ointment group and 0. 4% calomelgroup. The rabbits were given a single transdermal administration of 1. 56 g ? Kg"' (0. 039 g ? Cm" , corresponding to 2-fold of the human therapeutic dose). The contents of mercury in blood and main organs were measured by HG-AAS. The serum biochemical indexes including creatinine ( Cr) , BUN, AST, ALT were measured to reflex the function of liver and kidney. Result; The contents of blood mercury in the experimental groups showed no significant difference compared with control group, while the content of mercury didn' t increase obviously after single dose transdermal administration. The mercury contents of the experimental groups in liver and kidney were significantly higher than that of the control group, whereas there were no statistical significance in heart, spleen and brain. Among of the blood biochemical indexes, only ALT increased significantly in the experimental groups compared with that in the control group. Conclusion; There was little absorption of mercury and a definite accumulation of mercury in liver and kidney following single dosage transdermal administration of Yuhong ointment in rabbits.%目的:研究含0.4%轻粉的玉红膏单次给药后家兔体内汞的吸收及毒性,以考察玉红膏用药的安全性.方法:日本大耳白家兔12只,雌雄各半,分为3组,分别为基质(凡士林)对照组,玉红膏组,0.4%轻粉组.按1.56 g·kg-1(0.039 g·cm-2,相当于临床日用剂量的2倍)单次经皮给药,用氢化物-原子吸收法测定全血和主要脏器中的汞含量来确定体内汞的吸收情况,以血生化指标丙氨酸转氨酶(ALT),天冬氨酸转氨酶(AST),肌酐(Cr),血尿素氮(BUN)评价给药后对家兔

  5. 盐酸米诺环素软膏辅助治疗智齿冠周炎的临床观察%Clinical Observation of Minocycline Hydrochloride Ointment for Adjuvant Treatment of Pericoronitis

    Institute of Scientific and Technical Information of China (English)

    覃文献

    2016-01-01

    目的::探讨盐酸米诺环素软膏辅助治疗智齿冠周炎的临床效果。方法:选择某院2014年5月~2015年5月期间收治的108例智齿冠周炎患者的临床资料进行回顾性分析,按治疗方法不同分为治疗组(n =55)和对照组(n =53)。对照组患者采用碘甘油进行治疗,而治疗组患者则在对照组的基础上给予盐酸米诺环素软膏辅助治疗。观察两组患者的疼痛缓解时间及治疗时间差异,比较两种治疗方法下的临床总有效率。结果:治疗组的疼痛缓解时间为(2.28±0.97)d,总治疗时间为(8.51±3.24)d,均明显短于对照组的(5.73±1.84)d、(23.62±7.12)d;并且,治疗组显效41例,有效12例,无效2例,冠周炎治疗有效率为96.36%(53/55),明显高于对照组的77.36%(41/53),两组间差异比较均具有统计学意义(P <0.05)。结论:盐酸米诺环素软膏应用于智齿冠周炎的辅助治疗中,可显著缩短治疗时间,其疗效明显优于单纯碘甘油治疗,值得在临床上推广使用。%Objective:To explore the clinical results of minocycline hydrochloride ointment for the treat-ment of pericoronitis.Methods:108 patients with pericoronitis were selected from 2014 May to 2015 May in a hospital for retrospectively analyzed and were divided into the treatment group (n = 55 )and the control group (n =53)according to different treatment methods.The control group were treated with iodine glycerin and the treatment group were treated with minocycline hydrochloride ointment on the basis of the control group.The difference of the pain relief time and treatment time between the two groups were observed and the clinical total effective rate of the two treatment methods were compared.Results:The pain relief time of the treatment group was (2.28±0.97)d and the total treatment time was (8.5 1±3.24)d,significantly shorter than that (5.73±1.84)d,(23.62±7.12)d of the control group;And the treatment group were markedly effec-tive for 41 cases

  6. 消定膏治疗急性髌上滑囊炎的影像学评价%Imaging Evaluation of Xiaoding Ointment in the Treatment of Acute Patellar Bursitis

    Institute of Scientific and Technical Information of China (English)

    林志艳; 王学香; 王琳; 李莉

    2016-01-01

    OBJECTIVE:To evaluate clinical efficacy through comparing the change of CT image in infrapatellar fat pad before and after Xiaoding ointment in the treatment of acute patellar bursitis of knee joint. METHODS:73 patients with acute patellar bur-sitis were randomly divided into observation group(39 cases)and control group(34 cases). Observation group was given Xiaoding ointment for local application,qd,7 d as a courses,3 courses in total;control group was given triamcinolone acetonide 30 mg af-ter the extraction of articular cavity effusion,once a week,totally for 3 times. All patients of two groups underwent knee CT exami-nation for observation of the infrapatellar fat pad and articular cavity effusion volume change before and after treatment. Clinical ef-ficacies were compared between 2 groups. RESULTS:CT image alterations of treatment group showed that infrapatellar fat pad den-sity were decreased,anteroposterior diameter,vertical diameter,internal to external diameter were significantly reduced. The total effective rate of treatment group was 92.31%,which was better than that of control group(88.24%),with statistical significance (P<0.05). CONCLUSIONS:Xiaoding ointment demonstrate markedly curative effects in the treatment of acute patellar bursitis, and CT image is an effective method for diagnosis of infrapatellar fat pad.%目的:通过对比消定膏在治疗膝关节急性髌上滑囊炎前后患者髌下脂肪垫计算机体层成像(CT)图像的变化,评价其临床疗效.方法:73例急性髌上滑囊炎患者采用随机数字表法分为观察组39例和对照组34例.观察组患者给予消定膏局部敷贴, qd,7 d为1个疗程,共3个疗程;对照组患者在抽取关节腔积液后注入醋酸曲安奈德30 mg,每周1次,共治疗3次.两组患者治疗前后均行膝关节CT检查,对比观察髌下脂肪垫的变化,并比较临床疗效.结果:治疗后,观察组患者髌下脂肪垫的密度减低,前后径、上下径、内

  7. GC determination of menthol and Borneol in Shezhi Bingfu Ointment%GC法测定蛇脂冰肤软膏中薄荷脑和冰片的含量

    Institute of Scientific and Technical Information of China (English)

    许勇; 王柯; 季申

    2011-01-01

    目的:采用气相色谱法测定蛇脂冰肤软膏中薄荷脑、冰片的含量.方法:样品经正己烷超卢处理后,采用Agilent INNOWAX毛细管色谱柱(30 m×0.25 mm×0.25 μm);FID检测器;色谱条件:柱温:110℃,载气流速1.5 mL·min-1,进样口温度:250℃,检测器温度:300℃.进样量:1μL.结果:薄荷脑在0.0762~6.0995 mg·mL -范围内线性关系良好(r=0.9999,n=6),龙脑在0.0460375 ~3.683 mg·mL -范围内线性关系良好(r=0.9999,n=6).薄荷脑的平均加样同收率(n=9)为101.1%,龙脑的平均加样回收率(n=9)为101.7%.结论:该方法灵敏度高、专属性好、操作简便、重现性好.%Objective;To develop an GC method for the determination of menthol and Borneol in Shezhi Bingfu Ointment. Methods:The column was Agilent INNOWAX(30m xO. 25mm ×0. 25μm) ,and FID detector under following chromatography condition: column temperature was 110℃. The gas flow rate was 1. 5 mL · Min-1. Injector temperature was set at 250 °C and detector at 300 °C respectively. Results: Linear ranges was 0. 0762 - 6. 0995 mg · mL-1 for menthol and 0.0460375 - 3. 683mg · mL-1 for Borneol. The average recovery of menthol was 101. 1% (n =9) ,and average recovery of Borneol was 101.7%(n=9). Conclusions: The method is simple, sensitive , accurate, specific and reproducible in the quality control of Shezhi Bingfu Ointment.

  8. Effects of extracts of "seven-white ointment" on human melanocytes activity in vitro%七白膏方剂中药提取物对离体人黑素细胞的作用

    Institute of Scientific and Technical Information of China (English)

    陈玮莹; 宾向玲; 蔡绍先; 佘白蓉; 徐丹丹; 刘少辉; 何江; 蔡尔慧

    2011-01-01

    Objective: To assess the effects of extracts of components of "seven - white ointment" on metabolism of human melanocytes. Method: The human epidermal melanocytes were isolated, purified to establish human epidermal melanocyte model in vitro. The ingredients of seven kinds of herbs were extracted by alcohol respectively. Arbutin was used as positive control. The effects of the extracts of "seven - white ointment" on proliferation and tyrpsinase activity as well as melanogenesis of human melanocyte were tested at concentration of 25 μg/mL, 50 μg/mL, 100 μg/mL for each of the seven herbs, respectively. Results: Proliferation of melanocyte and the activity of tyrosinase were inhibited by low concentration (25 μg/mL) of Dahurian Angelica ( Ps < 0.05), but were induced at high concentration (100 μg/mL). The rest herb extracts inhibited proliferation of melanocyte and activity of tyrosinase. Melanin synthesis was inhibited by different concentration of the herbs. Conclusion: Different extracts of the herbs may influence the metabolism of melanocytes by regulating proliferation of melanocyte, inhibiting activity of tyrosinase and reducing melanogenesis in vitro.%目的:评价七白膏方剂中的药物对离体培养人黑素细胞的作用.方法:建立体外人表皮黑素细胞模型.醇提法提取各种中药活性成分.以熊果苷为实验对照,检测各种中药提取液对于离体培养人黑素细胞增殖、酪氨酸酶活性及黑素合成的干预作用.结果:低浓度白芷对黑素细胞增殖呈抑制作用(P<0.05),但高浓度时略呈激活作用.其它中药对黑素细胞增殖和酪氨酸酶活性有抑制作用.不同中药提取液对于黑素合成抑制作用不同.结论:各种中药提取液可影响黑素细胞增殖、酪氨酸酶活性和黑素合成,从而干预体外人黑素细胞的代谢.

  9. 甲氨蝶呤联合牛皮癣膏药外敷治疗银屑病的临床疗效%The Clinical Efficacy of Methotrexate Combined with Psoriasis Ointment for Treating Psoriasis

    Institute of Scientific and Technical Information of China (English)

    鲍志渊

    2015-01-01

    目的:探讨甲氨蝶呤内服联合牛皮癣膏药外敷治疗银屑病的临床疗效。方法选取2010—2014年治疗的银屑病患者268例为研究对象,采用随机数字表法将其分为试验组和对照组,对照组患者内服甲氨蝶呤,观察组患者在对照组治疗基础上联合牛皮癣膏药外敷,比较两组患者的治疗效果。结果观察组患者总有效率(97.0%)明显高于对照组(88.1%),差异有统计学意义(P<0.05)。结论甲氨蝶呤联合牛皮癣膏药外敷治疗银屑病,有助于缓解患者临床症状,提高治疗效果。%Objective To investigate the clinical efficacy of methotrexate combined with oral psoriasis ointment for treating psoriasis.Methods Selected in our hospital in 2010-2014 in the treatment of patients with psoriasis 268 cases as the object of study,using random number table were divided into treatment group and control group.Patients in control group were treated with oral methotrexate observed group of patients in the control group on the basis of the treatment combined with psoriasis plaster,were compared between the two groups of treatment effect.Results The total efficiency of the observation group(97.0%)was significantly higher than the control group(88.1%),the difference was statisticaly significant(P<0.05).Conclusion Methotrexate combined with psoriasis ointment for treating psoriasis,helps relieve clinical symptoms, improve the therapeutic effect.

  10. HPLC法同时测定痤疮清软中甲硝唑与维生B6的含量%Simultaneous Determinahon of Metronidazole and Vitamin B6 in Cuochuangqing Ointment by HPLC

    Institute of Scientific and Technical Information of China (English)

    邓雪男; 张振秋; 王海波; 刘威

    2011-01-01

    OBJECTIVE: To establish a method for simultaneous determination of metronidazole and vitamin B6 in Cuochuangqing ointment.METHODS: RP-HPLC wavelength switching method was adopted.DiamonsilTMC18 column was used with mobile phase consisted of methanol-water (10∶90).The detection wavelength was 291 nm at 0~6 min and 277 nm at 6.1~11 min and column temperature was set at 30 ℃.The flow rate was 1.0 mL·min-1 and injection volume was 10 μL.RESULTS: The linear range of metronidazole was 7.796~38.98 μg and that of vitamin B6 was 0.272~1.360 μg (r=0.999 7).Average recoveries were 98.9%(RSD=1.1%) and 97.0% (RSD=0.5%), respectively.CONCLUSION: The method is simple, specific and reproducible, accurate, reliable and suitable for quality control of Cuochuangqing ointment.%目的:建立同时测定痤疮清软膏中甲硝唑、维生素B6含量的方法.方法:采用反相高效液相色谱-切换波长法.色谱柱为DiamonsilTMC18,流动相为甲醇-水(10:90),0~6 min、6.1~11 min时检测波长分别为291、277 nm,柱温为30℃,进样量为10 μL,流速为1.0 mL·min-1.结果:甲硝唑、维生素B6进样量线性范围分别为7.796~38.98μg、0.272~1.360 μg(r均为0.9997);甲硝唑、维生素B6的回收率分别为98.9%(RSD=1.1%)、97.0%(RSD=0.5%).结论:所建立的方法操作简便、专属性高、重复性好,结果准确、可靠,可为痤疮清软膏质量控制提供依据.

  11. Therapeutic effects of minocycline hydrochloride ointment in treatment of early pericoronitis%盐酸米诺环素治疗早期智齿冠周炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    叶虎; 翟沁凯; 张建凤

    2014-01-01

    目的:探讨盐酸米诺环素局部治疗早期智齿冠周炎的临床疗效。方法选择急性智齿冠周炎患者49例,随机分成试验组27例,对照组22例。试验组经2%过氧化氢液和生理盐水交替冲洗冠周后,将盐酸米诺环素软膏注入智齿冠周及龈袋内,3d后复诊;对照组经冠周冲洗后于龈袋内置碘甘油,连续冲洗上药3d。记录评价疗效。结果智齿冠周炎病例中垂直(颊向)位所占比例明显高于近中(水平)位。试验组治疗有效率高于对照组,差异有统计学意义(P<0.05)。结论盐酸米诺环素是治疗早期智齿冠周炎的理想药物。%Objective To investigate the clinical effects of minocycline hydrochloride ointmemnt in the local treatment of early peri-coronitis.Methods Forty-nine cases of early pericoronitis of wisdom teeth were randomly divided into two groups.The experimental group (27 cases)was treated with minocycline hydrochloride ointment after routine pocket rinsing by 2%hydrogen dioxide solution and normal sa-line.The control group (22 cases)was treated with iodine glycerin after the same rinsing for 3 days.Therapeutic effects between the two groups were assessed 3 days later after treatment.Results The percentage of verti-buccal cases was higher than that of the mesio-horizontal. There was a significant difference in the effective rate between the experimental group and control group.Conclusion The minocycline hydro-chloride ointment is appropriate in the treatment of early pericoronitis.

  12. Effect of Anti-inflammatory and Analgesic Ointment in the Treatment of Phlebitis%消炎止痛膏治疗静脉炎的效果观察

    Institute of Scientific and Technical Information of China (English)

    冯婷

    2015-01-01

    Because of the clinical application of the drug to the intravenous route,it can cause the inflammation of the vein wal of the patients.In patients with phlebitis,the use of anti-inflammatory analgesic ointment,the ef ect of treatment of patients with local inflammation,explore the use of anti-inflammatory analgesic ointment,treatment time,care,observation points,anti-inflammatory analgesic cream is a kind of compound Chinese medicine with anti-inflammatory analgesic,clearing heat and dampness,dispersing blood stasis,the treatment,low price,easy operation,no obvious adverse reaction, greatly reducing the patient's economic burden.%临床上由于刺激性药物通过静脉途径的应用,会使患者的静脉血管壁发生炎症反应,血管受到不同程度的破坏,而发生静脉炎。在发生静脉炎患者中应用消炎止痛膏,通过对患者局部炎症情况治疗效果的观察,探讨在静脉炎患者中应用消炎镇痛膏的适应症、治疗时间、护理的观察要点等,消炎止痛膏是一种具有消炎止痛、清热除湿、散瘀化结作用的复方中药制剂,采用他的中药原理对静脉炎进行治疗,价格低廉,操作简便,无明显不良反应,极大的减轻了患者的痛苦,也减轻了患者的经济负担。

  13. 复方氟米松软膏联合液氮冷冻治疗疥疮结节208例疗效观察%Treatment effect observation of 208 patients with scabies tubercle treated with Compound Flumetasone Ointment combined with liquid nitrogen cryotherapy

    Institute of Scientific and Technical Information of China (English)

    刘诗; 张东兴; 赖洪涛; 姚明珠; 曾远娟

    2013-01-01

    Objective: To observe the clinical treatment effects of Compound Flumetasone Ointment Combined with liquid nitrogen cryotherapy on scabies tubercle. Methods: 410 patients with scabies tubercle in section for outpatients in our department were col ected and randomly divided into two groups, the control group and the observation group. 202 patients in the control group were treated with Compound Flumetasone Ointment, and 208 patients in the observation group were treated with Compound Flumetasone Ointment combined with liquid nitrogen cryotherapy. The treatment effects in the two groups were observed. Results: The total effective rate in the observation group with 208 patients was 94.71%, and the total effective rate in the control group with 202 patients was 87.50%. There were significances in respect to total effective rate in the two groups (p<0.05). Conclusion: Significant treatment effects could be achieved in clinical application for the treatment of Compound Flumetasone Ointment Combined with liquid nitrogen cryotherapy, which have better treatment effects than that of single treatment with Compound Flumetasone Ointment or liquid nitrogen cryotherapy.%目的观察复方氟米松软膏联合液氮冷冻治疗疥疮结节的临床疗效。方法选取我科门诊的410例疥疮结节患者,随机分成2组,对照组202例采用外涂复方氟米松软膏治疗,观察组208例在对照组基础上加用液氮冷冻治疗,对两组治疗效果进行观察分析。结果观察组208例患者中,总有效率为94.71%;对照组200例患者中,总有效率为87.50%。两组总有效率相比具有显著性(p<0.05)。结论使用复方氟米松软膏联合液氮冷冻治疗可在临床上收到显著的疗效,比单一治疗方法效果更好。

  14. Therapeutic effect of combined compound .umethasone ointment and compound lactic acid cream on palm-sole keratinizing eczema%复方氟米松软膏联合复方乳酸乳膏治疗掌跖角化性湿疹的疗效观察

    Institute of Scientific and Technical Information of China (English)

    汶春苗; 赵梓纲; 赵华; 郭秀丽; 李恒进

    2012-01-01

    Objective To observe the efficiency and safety of combined compound flumethasone ointment and compound lactic acid cream in treatment of palm-sole keratinizing eczema. Methods Ninety patients with palm-sole keratinizing eczema were randomly divided into treatment group (n=45) and control group (n=45). Patients in treatment group were treated with combined compound flumethasone ointment and compound lactic acid cream (once in the morning, once in the evening) and those in control group were treated with clobetasol propionate ointment for 6 weeks. The patients were followed up for two months. Results The total effective rate was significantly higher in the treatment group than in the control group (91.11% vs 68.89%, P<0.05) while the recurrent rate was significantly lower in the treatment group than in the control group (14.29% vs 42.11%, P<0.05 ) . Conclusion Combined compound flumethasone ointment and compound lactic acid cream is more effective than clobetasol propionate ointment on palm-sole keratinizing eczema.%目的 观察复方氟米松软膏联合复方乳酸乳膏治疗掌跖角化性湿疹的有效性和安全性.方法 将90例患者随机分为治疗组(n=45)和对照组(n=45);治疗组早晚各外用1次复方氟米松软膏,白天外用复方乳酸乳膏,次数不限;对照组单独外用丙酸氯倍他索软膏,两组均治疗6周,随访2个月.结果 治疗组和对照组有效率分别为91.11% 和71.11%(P<0.05),复发率分别为14.29% 和42.11%(P<0.05).结论 复方氟米松联合复方乳酸乳膏治疗角化性湿疹的疗效优于丙酸氯倍他索软膏.

  15. Development and validation of a stability-indicating RP-HPLC method for simultaneous assay of betamethasone dipropionate, chlorocresol, and for the estimation of betamethasone dipropionate related compounds in a pharmaceutical cream and ointment.

    Science.gov (United States)

    Johnston, Stephen E; Gill, Nicole L; Wei, Yu-Chien; Markovich, Robert; Rustum, Abu M

    2010-10-01

    A new stability-indicating reversed-phase HPLC (RP-HPLC) method has been developed and validated for simultaneous assay of betamethasone dipropionate (BD) and chlorocresol and also for the estimation of BD related compounds in a pharmaceutical cream matrix. In addition, this newly developed RP-HPLC method was also demonstrated as suitable for a pharmaceutical ointment product that does not contain chlorocresol. The RP-HPLC method uses a Waters SymmetryShield RP18 analytical column (150 × 4.6 mm). Water (mobile phase A) and acetonitrile (mobile phase B) were used in the gradient elution with a flow rate of 1.5 mL/min and detection wavelength at 240 nm. A Waters XBridge Shield RP18 analytical column (150 × 4.6 mm) was identified as an alternate column. The limit of detection (LOD) and the limit of quantitation (LOQ) are 0.02 μg/mL and 0.05 μg/mL, respectively. The precision of the method for BD is less than 0.3% RSD, and the accuracy of BD ranged from 99.5% to 102.6%. The stability-indicating capability of this method has been demonstrated by analyzing aged samples of the product. This RP-HPLC method was successfully validated per ICH guidelines and proved to be suitable for routine quality control use.

  16. 美宝疤痕软膏联合超声波导入治疗小儿烧伤瘢痕%MEBO Scar Ointment Combined with Ultrasonic Introduction in the Treatment of Pediatric Burn Scar

    Institute of Scientific and Technical Information of China (English)

    李桂茹; 陈永翀

    2013-01-01

    Objective To observe the progressing process and clinical therapeutic efficacy of MEBO Scar Oint-ment combined with Ultrasonic Introduction in treating pediatric scar from deep burns, and to explore the potential mecha-nism of the regenerative restoration of scarred skin tissue. Methods One child with topical scar of deep burn was treated with MEBO Scar Ointment combined with Ultrasonic Introduction Machine topically 2 ~3 times a day. The progressing processes and regenerative restoration situation of scar were recorded by regular return visit, examination and photos so as to observe, analyze and evaluate the therapeutic efficacy. Results One week after the treatment, the discomfortable symptoms of the child’s scar such as dryness, itching, pain and etc. were largely alleviated and the child could sleep well at night. Two weeks after the treatment, the hyperplastic scar and keloid became smaller, softer and smoother gradually. Six months later, the hyperplastic scar and keloid disappeared and the topical skin was smooth, flattened and elastic. The skin color of superficial scar became normal or almost normal from the previous purple, and the appearance and functions recovered well. Twelve months after the treatment, the elasticity of skin improved better to be almost normal. The size of skin previously in dark and white color obviously reduced and the skin color turned normal gradually. The joint activity and functions recovered completely and no adverse effect was left for the child's development and growth. Conclusion Pediatric scar of deep burn realized gradual recovery of skin normal structure and functions when managed with MEBO Scar Ointment combined with Ul-trasonic Introduction Machine, of which the affirmative clinical effects may contribute to MEBO Scar Ointment in that it can initiate the regeneration of potential regenerative cells, guide the scar tissue cells to develop towards physiological regenera-tion and terminate the abnormal pathological

  17. 炎痛平透皮软膏的制备及活血作用的探讨%Preparation and promoting blood circulation effect of Yantongping transdermal ointments

    Institute of Scientific and Technical Information of China (English)

    何爱明; 徐洁; 王艺辉; 林世明

    2012-01-01

    Objective To find out the best prescription method for Yantongping transdermal ointments through orthogonal design and research on the effect of promoting blood circulation. Methods With 60 minutes in vitro cumulative penetration rate, using L9(34) orthogonal experiment, the best formula and technology were found out through grinding method, and quality thereafter was e-valuated. Mice was picked up as blank groups and model groups, each respectively was divided into six smaller groups as Vaseline, Vaseline and Fatty Alcohol, Yantongping transdermal ointments( low dosage) , Yantongping transdermal ointments( medium dosage) , Yantongping transdermal ointments( high dosage) and Voltaren Emulsions. A A and AV were measured before and after modeling by microcirculation method and microscopic micro-distance measuring method , while the blood circulation function of each medicine by the scoring of the blood of veinule was compared. Results The best prescription was confirmed by A2B2C3D2, that was with the weight of the traditional Chinese drugs (TCD) Vaseline ratioes ( A) to 50% , with the weight of TCD and Fatty Alcohol ratios ( B) to 25% , the order of reagent was as follow; Fatty Alcohol, TCD, Vaseline . The grinding temperature was 80 X. , and it passed five quality evaluation as physical appearance, melting point, water value, stability, irritation. Before modeling, in the A A level measured, Yantongping group (low dosage) had statistical significance over Vaseline and Fatty Alcohol group in 30 min(P<0.05= ,while Yantongping group (medium dosage and high dosage) had obviously statistical significance over Vaseline and Fatty Alcohol group in different time periods in the A A and A V level (P<0. 01=. In the blood flow quality evaluation measured, Yantongping group (low dosage) had statistical significance over Vaseline and Fatty Alcohol group in 20 min, 30 min ( P<0. 05 ) ; while Yantongping group ( medium and high dosage) had obviously significant

  18. 积雪苷霜软膏对兔耳增生性瘢痕组织中S mad4蛋白表达的影响%Effects of asiaticoside ointment on Smad4 protein expression in rabbit's hypertrophic scars

    Institute of Scientific and Technical Information of China (English)

    江宇峰; 伍超; 吴佳俊; 王极宇; 庄文豪; 马腾飞; 江洁美; 杨雁

    2015-01-01

    Objective To investigate the effects of asiaticoside ointment on Smad4 protein expression in rabbit's hypertrophic scars. Methods The eighteen New Zealand white rabbits were randomly distributed into the control group,the model group and the asiaticosi-de ointment treatment group.The scars were established on the ventral surface of rabbits'ears in the model and asiaticoside ointment treatment group.On post-operative day 21,the scars of asiaticoside ointment treatment group were thinly daubed with asiaticoside oint-ment twice a day for 28 days.Meanwhile,those of the control and model groups were applied with ointment base.Morphological charac-teristics were observed and recorded by a camera every week.All animals were executed and the scars or corresponding skin tissues were harvested for histopathology,hydroxyproline and Smad4 protein detection on post-operative day 49.Results The growth of scars in the model group was more rapid than that of the asiaticoside ointment treatment group.Pathological evaluation shows that representative fibrosis occurred in the scars of the model group,while that was markedly alleviated in the scars of the asiaticoside ointment treatment group.The hydroxyproline content of scars in the model group observably increased compared with that in the control group(P<0.01), while significantly decreased in the asiaticoside ointment treatment group(P<0.01).The expression of Smad4 protein was remarkably up-regulated in hypertrophic scar tissue.Nevertheless,it was notably decreased in asiaticoside ointment treatment(P<0.01 ).Conclu-sions The mechanisms of anti-hypertrophic scar effects of asiaticoside maybe involve inhibiting Smad4 protein expression.%目的:探讨积雪苷霜软膏对兔耳增生性瘢痕组织中Smad4蛋白表达的影响。方法新西兰大耳白兔18只,随机分为正常对照组、模型组、积雪苷霜软膏组。模型组和积雪苷霜软膏组建立兔耳腹侧面增生性瘢痕模型,术后21 d,积雪苷霜

  19. Effects of Zhuhong ointment on mercury cumulation and renal organization modality in skin-impaired model rat%朱红膏对破损皮肤模型大鼠汞蓄积及肾组织形态的影响

    Institute of Scientific and Technical Information of China (English)

    林含; 张旭辉; 董建勋; 李建荣; 贺蓉; 彭博; 徐启华; 王乐平; 罗玲

    2012-01-01

    Objective: To study the effects of Zhuhong ointment on accumulation in the body of mercury and the pathological morphology changes of kidney, via the measurement of related indicators of the skin-impaired model rat Method: Eighty-eight SD rats were randomly divided into the impairment control group, and high-, middle-, low-dose Zhuhong ointment groups. Each group was treated by corresponding methods for 4 weeks, and recovering for 4 weeks. Urinary potein (PRO), pH, Beta iV-acetyl aminoglycosi-dase enzymes (NAG) and β2-microglobulin (β2-MG) contents in urine were taken as monitoring indexes, blood urea nitrogen (BUN) and serum creatinine ( SCr) in blood and the levels of mercury in urine, blood and kidney were tested, and the pathological morphology changes of kidney were observed. Result: After treatment for 4 weeks, compared with impairment control group, the levels of mercury in urine, blood and kidney in every dose group increased significantly (P < 0. 01). And the relation exists between toxicity and dose on Zhuhong ointment After recovery for 4 weeks, the levels of mercury in urine and blood in every dose group restore normal, while the level of mercury in kidney in high- dose group still increased (P < 0. 01). The level of NAG increased only in high- dose group. There was no significant difference in NAG contents between Zhuhong ointment groups and the impairment control group (P < 0. 05). Conclusion: Excess using Zhuhong ointment repeatedly may lead to accumulation of mercury and pathological morphology changes of kidney. So the levels of mercury in the body and related indicators of renal functions should be tested in clinical when long-term using Zhuhong ointment%目的:通过对破损皮肤模型大鼠连续给予朱红膏4周和停药4周各相关指标的检测,探讨其对汞蓄积和肾组织形态的影响,为临床安全用药提供科学依据.方法:将大鼠随机分成4组:破损皮肤对照组、朱红膏低、中

  20. Clinical efficacy of narrow-band UVB phototherapy combined with tacrolimus ointment in the treatment of vitiligo%窄谱中波紫外线联合他克莫司软膏治疗白癜风的临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    刘树雷; 廖军; 邓晓玲; 王鹰; 孙仁美; 贺旭

    2014-01-01

    目的:探讨窄谱中波紫外线联合他克莫司软膏对白癜风的治疗作用。方法:收集我院2011年至2013年门诊共90例白癜风患者,随机分为两组,每组各45例患者,分为窄谱中波紫外线联合他克莫司软膏治疗组及他克莫司软膏治疗组。随访6个月,分析两组患者治愈率,并对不同部位、不同期、不同类型白癜风的治疗情况进行比较分析。结果:窄谱中波紫外线联合他克莫司软膏对白癜风的治愈率明显高于单用他克莫司软膏组,头面部白癜风治疗有效率优于肢端部、躯干四肢部,肢端部白癜风治疗效果最差。寻常型白癜风的疗效较节段型白癜风疗效好。进展期白癜风较稳定期疗效好。结论:窄谱中波紫外线联合他克莫司软膏对白癜风具有较好的治疗作用。%Objective: To investigate the therapeutic effect of narrow-band UVB combined with tacrolimus ointment for vitiligo treament. Methods:From 2011 to 2013, 90 cases of patients with vitiligo in our hospital , were randomly divided into two groups, each group 45 patients. They were divided into narrow-band UVB phototherapy combined with tacrolimus ointment treatment group and ta-crolimus ointment treatment group.Those patients were followed-up for 6 months.Two groups' cute rate were analyzed and different parts of the different phases, different types of vitiligo treatment were compared.Results: Narrow-band UVB phototherapy combined with tacrolimus ointment for vitiligo cure rate was significantly higher than that of single use of tacrolimus ointment group, the head and face of vitiligo treatment effective rate higher than the extremities, trunk limbs acral of vitiligo treatment effect is the worst.Treat-ment effect of vitiligo vulgaris is better than segmental vitiligo. Treatment effect of Vitiligo in progress period is better than it in table period. Conclusion:narrow-band UVB phototherapy combined with tacrolimus ointment

  1. Appl ication effect of dexamethasone ointment with gauze dressings for cancer patients with PICC catheter related severe atopic dermatitis%地塞米松软膏加纱布敷料在肿瘤病人PICC导管相关严重过敏性皮炎中的应用效果

    Institute of Scientific and Technical Information of China (English)

    余喜梅; 任燕; 摆江萍; 贲艳丽

    2014-01-01

    [目的]探讨地塞米松软膏加纱布敷料在经外周静脉置入中心静脉导管(PICC)置管后严重皮肤过敏性皮炎的临床应用。[方法]采用回顾性分析,对本科室 PICC置管的142例乳腺癌病人中的10例置管后出现严重皮肤过敏性皮炎的病人进行处理和分析。[结果]142例乳腺癌置管病人中10例置管后出现严重皮肤过敏性皮炎,发生率7.04%,经地塞米松软膏加纱布敷料换药后症状全部缓解并保留导管。[结论]地塞米松软膏加纱布敷料换药应用于 PICC 导管相关严重过敏性皮炎病人有良好的治疗效果。%Obj ective:To probe into the clinical application of exam-ethasone ointment with gauze dressings in patients with severe skin allergic dermatitis after PICC.Methods:In 142 cases of breast cancer patients receiving PICC,1 0 cases of patients with severe skin allergic dermatitis were treated and analyzed by using retrospective analysis. Results:10 cases appeared severe skin allergic dermatitis in 142 cases of breast cancer patients with PICC,the incidence was 7.04%;after dexamethasone ointment with gauze dressings,all symptoms were re-leased and the catheters were kept.Conclusion:Dexamethasone oint-ment with gauze dressings used in PICC catheter related serious skin allergic dermatitis patients has good therapeutic effect.

  2. 二黄新伤止痛软膏合七味三七口服液治疗急性腰扭伤119例临床体会%Clinical experience of Erhuang new injury pain ointment with seven flavor three seven oral liquid in the treatment of acute lumbar sprain

    Institute of Scientific and Technical Information of China (English)

    宁兴明; 王兰; 伍亮; 高繁; 虞亚明

    2015-01-01

    目的:观察二黄新伤止痛软膏外敷配合七味三七口服液口服治疗急性腰扭伤的临床疗效。方法:选取119例急性腰扭伤患者为观察对象,采用二黄新伤止痛软膏外敷,七味三七口服液口服治疗,观察其疗效。结果:临床治愈98例,显效16例,好转4例,无效1例,总有效率99.15%。结论:二黄新伤止痛软膏外敷配合七味三七口服液口服治疗急性腰扭伤疗效较好。%Objective To observe the clinical effect of Erhuang new injury analgesic ointment with seven kinds of notoginseng oral liquid in the treatment of acute lumbar sprain.Methods seleet 119 cases of acute lumbar sprain as the research obieet,adopt Erhuang new injury analgesic ointment topical,oral seven kinds of seven oral liquid,to observe the dinicall effect.Results the the clinical cure in 98 cases,16 cases markedly effective,4 cases improved,1 cases ineffective,the total efficiency of 99.15%.Conclusion The Erhuang new injury analgesic ointment with seven kinds of oral liquid in the treatment of acute lumbar sprain obvious curative effect.

  3. To observe the wishful golden powder mannitol combined heparin ointment in the efficacy of phlebitis%如意金黄散联合肝素钠软膏治疗甘露醇所致静脉炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    屠春香

    2012-01-01

      Objective:To observe the wishful golden powder mannitol combined heparin ointment in the efficacy of phlebitis. Methods:12 cases of phlebitis caused by inputting mannitol ,the wishful golden powder with white vinegar move into mushy ,then wet compress on the site phlebitis,40 minutes later ,the cream of local heparin coating. Results:the best golden scattered joint heparin sodium ointment for mannitol phlebitis got by 8 cases,effective after 4 cases. Conclusion:best golden scattered and heparin sodium ointment joint wish strengthening,anti-inflammatory,reduce sweling pain role..to therapy had significant inhibitory effects caused by intravenous mannitol.%  目的观察如意金黄散联合肝素钠软膏治疗甘露醇所致静脉炎的疗效。方法因输入甘露醇引起静脉炎的患者12例,用白醋将如意金黄散调成糊状,湿敷于发生静脉炎的部位,40分钟后局部再涂擦肝素钠软膏。结果如意金黄散联合肝素钠软膏治疗甘露醇所致静脉炎后显效8例,有效4例。结论如意金黄散与肝素钠软膏联合使用可以加强消肿、抗炎,减轻疼痛的作用,对治疗甘露醇所致静脉炎效果显著。

  4. Analysis of Minocycline Hydrochloride Ointment in the Treatment of Patients With Chronic Severe Periodontitis%盐酸米诺环素软膏辅助治疗重度慢性牙周炎患者的疗效分析

    Institute of Scientific and Technical Information of China (English)

    仲琳; 陈青宇; 贺娜; 关敏

    2015-01-01

    Objective To investigate the clinical efficacy of minocycline hydrochloride ointment in the treatment of patients with chronic periodontitis. Methods Clinical data of 52 patients with severe chronic periodontitis admitted in our hospital from March 2014 to May 2015 were retrospectively analyzed, digital mode is divided into odd and even numbers of the control group (iodine glycerin) and study group (hydrochloric acid minocycline ointment), 26 cases in each group. Results The clinical efficacy study group than the control group. Conclusion The use of minocycline hydrochloride ointment in the treatment of chronic periodontitis can effectively improve the clinical symptoms, improve clinical effcacy.%目的:探讨盐酸米诺环素软膏辅助治疗重度慢性牙周炎患者的临床疗效。方法回顾性分析我院2014年3月~2015年5月收治的52例重度慢性牙周炎患者的临床资料,采用数字单双号的模式随机分为对照组(碘甘油)与研究组(盐酸米诺环素软膏),每组各26例。结果研究组的临床疗效优于对照组。结论采用盐酸米诺环素软膏治疗慢性牙周炎能够有效改善患者的临床症状,提升临床疗效。

  5. Simultaneous Determination of Gallic Acid and Ellagic Acid in Xihe Majun Ointment by HPLC%HPLC法同时测定西诃蜜膏中没食子酸和鞣花酸的含量

    Institute of Scientific and Technical Information of China (English)

    李建梅; 买买提·霍吉; 希尔艾力·吐尔逊

    2016-01-01

    目的:建立同时测定西诃蜜膏中没食子酸和鞣花酸含量的方法。方法:采用高效液相色谱法。色谱柱为X-Bridge C18,流动相为甲醇-乙腈-0.2%磷酸水溶液(梯度洗脱),流速为1.0 ml/min,检测波长为254 nm,柱温为30℃,进样量为10μl。结果:没食子酸和鞣花酸的检测进样量线性范围分别为0.132~0.792、0.1080~0.6482μg(r均为0.9999);精密度、稳定性、重复性试验的RSD<3%;加样回收率分别为95.15%~99.69%(RSD=1.64%,n=9)、97.24%~100.43%(RSD=1.24%,n=9)。结论:该方法操作简单、结果准确、灵敏度高,可用于西诃蜜膏中没食子酸和鞣花酸的含量测定。%OBJECTIVE:To establish a method for simultaneous determination of gallic acid and ellagic acid in Xihe majun ointment. METHODS:HPLC method was performed on the column of X-Bridge C18 with mobile phase of methanol-acetoni-trile-0.2% Phosphoric acid solution (gradient elution) at a flow rate of 1.0 ml/min,detection wavelength was 254 nm,detection temperature was 30 ℃,and injection volume was 10 μl. RESULTS:The linear range was 0.132-0.792 μg for gallic acid (r=0.999 9) and 0.108 0-0.648 2 μg for ellagic acid (r=0.999 9);RSDs of precision,stability and reproducibility tests were lower than 3%;recoveries were 95.15%-99.69%(RSD=1.64%,n=9) and 97.24%-100.43%(RSD=1.24%,n=9). CONCLUSIONS:The method is simple,accurate and sensitive,and can be used for the content determination of gallic acid and ellagic acid in Xihe majun ointment.

  6. 皮肤瘙痒症血清P物质的检测及辣椒碱软膏的疗效观察%Detection of Serum Substance P of Patients with Pruritis and Efficacy of Capsaicin Ointment on Pruritis

    Institute of Scientific and Technical Information of China (English)

    杨闰平; 刘元林

    2012-01-01

    目的 检测P物质在瘙瘁症患者中的水平,观察辣椒碱软膏对皮肤瘙痒症的疗效及对P物质的影响.方法 选取门诊确诊瘙痒症患者120例,随机分为两组,分别外用辣椒碱和丁酸氢化可的松治疗3周,观察瘙痒的缓解程度及不良反应.治疗前后ELISA法检测血清P物质浓度.结果 瘙痒症患者血清P物质显著高于正常人(P<0.000 1);治疗前后两组血清P物质差异均有统计学意义(P <0.000 1);治疗后辣椒碱组血清P物质浓度显著低于丁酸氢化可的松组(P<0.05).辣椒碱组和丁酸氢化可的松组的有效率分别为86.67%和70.00%,差异有统计学意义(P<0.05);丁酸氢化可的松组缓解瘙痒的平均起效时间(4.5±1.5)d较辣椒碱组(5.1±1.4)d明显缩短(P<0.05).结论 P物质在瘙瘁症的致痒中起重要作用,辣椒碱能有效降低血清中P物质,对治疗皮肤瘙痒症安全有效.%Objective To investigate the serum concentration of substance P in patients with pruritis, and to observe the effects of capsaicin ointment on the serum substance P and pruritis. Methods One hundred and twenty outpatients with pruritis were randomly assigned to the capsaicin group and hydrocortisone butyrate group, capsaicin ointmen and hydrocortisone butyrate cream were given to each group respectively for 3 consecutive weeks. Efficacy and side effects were recorded in detail. Sera from patients were isolated before and after treatment, then serum substance P was assayed with ELISA kit. Results The concentration of serum substance P in patients with pruritis was higher than that in normal control (P < 0. 000 1) ; the serum substance P in both group of the pre- and post-treatment were significantly different (P <0. 000 1) ; the concentration of serum substance P of capsaicin group was lower than that in hydrocortisone butyrate group at the end of trial (P<0. 05); the effective rates of capsaicin and hydrocortisone butyrate on pruritis were 86

  7. 米诺环素软膏与碘甘油治疗急性智齿冠周炎的效果比较%Minocycline Ointment and Iodine Glycerin in Treatment of Acute Pericoronitis of Wisdom Tooth Effect

    Institute of Scientific and Technical Information of China (English)

    龚小利

    2013-01-01

    Objective:To explore the clinical value of minocycline ointment treatment acute pericoronitis. Methods:160 cases of acute pericoronitis were randomly divided into observation group and control group with each 80 cases, with saline and 3%hydrogen peroxide alternately flushing Pericoronal blind bag, wash clean, dry, wet insulation, the observation group will minocycline ointment gently injection Pericoronal and blind to the bottom of the bag at the bottom of the bag, soft paste overflow, a total of 1 times;the control group iodine glycerin filling, liquid will be placed in the periodontal pocket, then the oral probe liquid flow gradually into the periodontal pocket, once every other day. Results:The observation group pain relief time shorter than the control group (P<0.05), after treatment 5 days the observation group total effective rate is high and the control group (P<0.05). Control group 3 cases due allergy to iodine and iodine preparations on gingival irritation from the treatment, the observation group had no adverse reactions. Conclusion:Minocycline hydrochloride can maintain high concentration in the local, can significantly improve the clinical symptoms, improve clinical efficacy, and adverse reactions.%目的:探讨米诺环素软膏治疗急性智齿冠周炎的临床价值。方法:160例急性智齿冠周炎患者随机分观察组和对照组各80例,先用生理盐水和3%双氧水交替冲洗冠周盲袋,冲洗干净后,擦干,隔湿,观察组将米诺环素软膏轻轻注入冠周及盲袋底,至袋底有软膏溢出,共1次;对照组碘甘油灌注,将药液放置于牙周袋口,再用口腔探针将药液流逐渐导入到牙周袋内,隔日一次。结果:观察组疼痛缓解时间短于对照组(P<0.05),治疗5天以后观察组总有效率高与对照组(P<0.05)。对照组3例因碘过敏及碘制剂对牙龈刺激性退出治疗,观察组无不良反应发生。结论:盐酸米诺环素能在局部维持较

  8. HPLC双波长法同时测定复方维A酸软膏中2主药的含量%Simultaneous Content Determination of 2 Components in Compound Tretinoin Ointment by Dual Wavelength HPLC

    Institute of Scientific and Technical Information of China (English)

    魏立明; 宋霞; 宋三孔; 杨效宇; 焦海胜

    2012-01-01

    OBJECTIVE: To establish the method for the simultaneous determination of tretinoin and chlorpheniramine maleate in compound tretinoin ointment. METHODS: HPLC method was adopted. Luna da column was used with mobile phase consisted of methanol-phosphate buffer (0.02 mol-L-1 potassium dihydrogen phosphate, pH adjusted to 7.0 using 1 mol·L-1 sodium hydroxide, F/K=80:20) at a flow rate of 1.0 mL·min-1. The column temperature was 30 °C and injection volume was 20 μL. The detection wavelength was set at 350 nm and 262 nm for tretinoin and chlorpheniramine maleate, respectively. The content of tretinoin and chlorpheniramine maleate was determined by external standard method. RESULTS: The liner range of tretinoin was 20~100 μg·mL-1 (t-=0.999 9) with an average recovery rates of it at low, medium and high concentrations were 98.48% , 97.15%, 98.88% (RSD=0.92%). The liner range of chlorpheniramine maleate was 30-150 μg·mL-1 (r=0.999 9) with an average recovery rates of it at low, medium and high concentrations were 100.47% , 99.01% , 99.75% (RSD=0.83% ). CONCLUSION: The established method is simple, accurate and reproducible. It can be used for the quality control of compound tretinoin ointment.%目的:建立同时测定复方维A酸软膏中维A酸和马来酸氯苯那敏含量的方法.方法:采用高效液相色谱法.色谱柱为Luna C1.柱,流动相为甲醇-磷酸盐缓冲液(0.02 mol· L-1磷酸二氢钾,用1 mol·L-1氢氧化钠调节pH至7.0,V/V) =80:20,流速为1.0 mL· min-1,进样量为20μL,柱温为30℃,维A酸的检测波长为350 nm,马来酸氯苯那敏的检测波长为262 nrn.采用外标法计算含量.结果:维A酸检测浓度在20~100 μg·mL-1范围内与峰面积积分值呈良好的线性关系(r=0.999 9),低、中、高平均加样回收率分别为98.48%、97.15%、98.88% (RSD=0.92%);马来酸氯苯那敏检测浓度在30~150 μg·mL-1范围内与峰面积积分值呈良好的线性关系(r=0.999 9),低、中、高平

  9. Effects of topical application of silver sulfadiazine cream, triple antimicrobial ointment, or hyperosmolar nanoemulsion on wound healing, bacterial load, and exuberant granulation tissue formation in bandaged full-thickness equine skin wounds.

    Science.gov (United States)

    Harmon, Caroline C Gillespie; Hawkins, Jan F; Li, Jianming; Connell, Sean; Miller, Margaret; Saenger, Megan; Freeman, Lynetta J

    2017-05-01

    OBJECTIVE To determine the effects of 3 topically applied treatments (1% silver sulfadiazine cream [SSC], triple antimicrobial ointment [TAO], and hyperosmolar nanoemulsion [HNE]) on microbial counts, exuberant granulation tissue (EGT) development, and reepithelialization of contaminated wounds at the distal aspect of the limbs of horses. ANIMALS 8 healthy adult horses. PROCEDURES A 2.5 × 2.5-cm, full-thickness, cutaneous wound was created at the dorsal aspect of each metacarpus and metatarsus (1 wound/limb/horse), covered with nonadhesive dressing, and bandaged. Wounds were inoculated with bacteria and fungi the next day. Each wound on a given horse was randomly assigned to 1 of 4 treatment groups (SSC, TAO, HNE, or no topical treatment [control]). Bandage changes, culture of wound samples, treatments, photography for wound measurements, and biopsy were performed at predetermined time points. Time (days) until wound closure, number of EGT excisions, microbial counts, and scores for selected histologic characteristics were compared among groups. RESULTS Median time to wound closure for all groups was 42 days. Time to wound closure and histologic characteristics of wound healing did not differ among groups. Least squares mean microbial counts were significantly higher for HNE-treated wounds on days 9 and 21, compared with SSC-treated and TAO-treated wounds, but not controls. Proportions of SSC-treated (7/8) or HNE-treated (5/8) wounds needing EGT excision were significantly greater than that of TAO-treated (1/8) wounds. The proportion of SSC-treated wounds with EGT excision was greater than that of controls (3/8). CONCLUSIONS AND CLINICAL RELEVANCE None of the treatments resulted in more rapid wound closure, compared with that for untreated control wounds under the study conditions. When treatment is warranted, TAO may help to limit EGT formation.

  10. Efficacy Evaluation of Tacrolimus Ointment and Kouyanqing Granules in Treatment of Erosive Oral Lichen Planus%他克莫司软膏加口炎清颗粒治疗糜烂型口腔扁平苔藓的短期疗效评价

    Institute of Scientific and Technical Information of China (English)

    曾宪涛; 姚馨蕙; 耿发云

    2011-01-01

    目的 评价0.03%他克莫司软膏加口炎清颗粒治疗糜烂型口腔扁平苔藓患者的疗效.方法 80例糜烂型口腔扁平苔藓患者,试验组和对照组各40例.试验组用0.03%他克莫司软膏加口炎清颗粒治疗,对照组用0.02%丙酸氯倍他索软膏治疗.结果 治疗4周后试验组总有效率为92.50%,对照组为65.00%,差异有统计学意义(χ2=9.038,P<0.05).试验组和对照组的不良反应率分别为12.50%(5/40)和17.50%(7/40),差异无统计学意义(χ2=0.392,P>0.05).结论 0.03%他克莫司软膏加口炎清颗粒治疗糜烂型口腔扁平苔藓患者短期疗效可靠.%Objective To evaluate the effect of 0.03% Tacrolimus ointment and kouyanqing granules on treatment of erosive oral lichen planus. Methods Eighty cases of erosive oral lichen planus were randomly divided into control group and observation group, and control group were treated with clobetasol propionate ointment, while observation group were treated with 0.03% tacrolimus ointment and kouyanqing granules. Results After4-weeks' treatment, the total efficacy rate of the observation group is higher than that of the control group, with significant difference. Conclusion Kouyanqing granules and 0.03% tacrolimus ointment has good curative effect on treatment of erosive oral lichen planus .

  11. Curative effects observation of extracting blister fluid combined with wiping ointments nursing for bullous pemphigoid treatment%改良疱液抽取术联合擦药护理治疗大疱性类天疱疮的效果观察

    Institute of Scientific and Technical Information of China (English)

    朱蓓蓓; 王妍妍; 宗岩; 曹春艳

    2015-01-01

    目的:探讨改良疱液抽取术联合擦药护理治疗大疱性类天疱疮的疗效。方法将28例大疱性类天疱疮患者按照随机数字表法分为观察组和对照组各14例,两组均给予常规系统药物治疗。观察组采用改良疱液抽取术联合擦药护理的方法,对照组行常规疱液抽取术后由患者自行涂抹外用药,比较两组患者疗效。结果观察组患者新发水疱停止出现、糜烂面干涸时间、激素减量时间均短于对照组,两组比较差异有统计学意义(P<0.05)。结论改良疱液抽取术联合擦药护理可促进水疱愈合,减轻疼痛,降低感染发生率,缩短病程。%Objective To observe the clinical effects of patients with Bullous Pemphigoid by improved extracting blister fluid and wiping ointments nursing. Methods A total of 28 patients were randomly divided into observational group (n=14) and control group (n=14). All the patients were treated with common therapy. For patients in the observational group, they used improved extracting blister fluid combined with wiping ointments nursing, while patients of the control group underwent extracting blister fluid combined with wiping ointments by themselves. The curative effects were compared between two groups. Results The period of no new blisters, periods of blisters drying and reducing incretion to half amount in observation group were shorter than these in the control group (P<0. 05). Conclusions Therapy of extracting blister fluid combined with wiping ointments nursing can promote the blister to heal, relieve pain, reduce incidence of infection and length of disease progress.

  12. Clinical observation of therapeutic effect of Tacrolimus Ointment in the treatment of patients with erosive oral lichen planus%他克莫司软膏治疗糜烂型口腔扁平苔藓的效果观察

    Institute of Scientific and Technical Information of China (English)

    吕晓君

    2012-01-01

    Objective: To evaluate the efficacy of Tacrolimus Ointment in the treatment of patients with erosive oral lichen planus. Methods: 62 patients in our department of our hospital were divided into two groups (group A and B). Group A was treated with Tacrolimus Ointment and group B was treated with Halometasone Ointment, the time was 8 weeks in a randomized clinical trial. Results: After treatment of 2 months, in the group A and B, the efficacy rate was 90.3%, 64.5% respectively, and the relapse rate within 6 months after treatment was 9.1% and 60.0% respectively, there were significant differences in the two groups (all P<0.05). Conclusion: The results of the present work demonstrate that Tacrolimus Ointment is an effective therapy for oral lichen planus.%目的:观察他克莫司软膏局部用药治疗糜烂型口腔扁平苔藓的疗效.方法:选择2009年6月~2011年1月在我科就诊的患者共62例,将其随机分成A组(应用他克莫司软膏局部涂擦)和B组(应用卤米松乳膏局部涂擦),疗程8周.结果:用药2个月后,A组有效率为90.3%,B组有效率为64.5%;停药6个月后治疗组复发率为9.1%,对照组复发率为60.0%.两组比较差异均有统计学意义(均P<0.05).结论:他克莫司软膏局部涂抹治疗糜烂型口腔扁平苔藓具有良好的临床疗效.

  13. 莫匹罗星软膏治疗皮肤感染的临床效果分析%Clinical effect of mupirocin ointment on treatment of skin infections

    Institute of Scientific and Technical Information of China (English)

    李建; 李涛; 陈光茂; 张择榕; 周碧海

    2016-01-01

    目的 探讨莫匹罗星软膏治疗皮肤感染的临床效果,为临床选择有效药物提供依据.方法 2014年10月-2015年10月在医院收治的皮肤轻中度感染患者150例为研究对象,采取随机的方法分为观察组与对照组,每组各75例;两组患者均给予常规的抗菌药物进行治疗,在此基础上,观察组给予莫匹罗星软膏涂抹患处,每日3次,连续使用7 d;观察两组患者治疗效果和病原菌清除率,采用SPSS 19.0对数据进行统计分析.结果 150例皮肤感染患者中检出金黄色葡萄球菌62株 、大肠埃希菌43株 、铜绿假单胞菌18株 、凝固酶阴性葡萄球菌10株 、溶血链球菌9株 、其他8株;外科创伤55例占36.66%、蜂窝织炎46例占30.67%、动物咬伤21例占14.00%、糖尿病皮肤溃疡15例占10.00%、其他13例占8.67%;观察组患者治疗有效率为97.33%、对照组为86.67%,观察组治疗有效率明显高于对照组,差异有统计学意义(P<0.05);观察组细菌清除率为96.00%、对照组为85.33%,观察组细菌清除率明显高于对照组,差异有统计学意义(P<0.05).结论 莫匹罗星软膏治疗皮肤感染临床效果显著,细菌清除率较高.%OBJECTIVE To observe the clinical effect of mupirocin ointment on treatment of skin infections so as to provide guidance for reasonable clinical use of antibiotics .METHODS A total of 150 patients with mild and moder-ate skin infections who were treated in hospitals from Oct 2014 to Oct 2015 were recruited as the study objects and randomly divided into the observation group and the control group ,with 75 cases in each .Both groups were trea-ted with conventional antibiotics ,the observation group was given additional mupirocin ointment for smearing of the affected area ,three times a day ,continuous use for 7 days .The therapeutic effects and clearance rates of pathogens were observed and compared between the two groups of patients ,and the statistical analysis of data was performed

  14. 5%茶树油眼膏治疗蠕形螨相关鳞屑性睑缘炎%The use of 5% tea oil ointment in the treatment of scaly blepharitis associated with ocular demodicosis

    Institute of Scientific and Technical Information of China (English)

    高莹莹; 黄丽娟; 董雪青; 赵华轩; 许锻炼

    2016-01-01

    Objective To discuss the clinical efficacy of 5% tea tree oil ointment in treating scaly blepharitis, which is associated with demodex.Methods In this prospective clinical study, a total of 240 outpatients diagnosed with scaly blepharitis in the Second Affiliated Hospital of Fujian Medical University between June 2007 and June 2013 were included in the study.The mean age was 48.7±13.7 years.Demodex was positive in every eyelash sample.The degree of ocular discomfort was judged by an ocular discomfort score.The method of treatment: Lid scrub with 5% tea tree oil ointment bilaterally once every night.Patients returned for evaluations every two weeks, and the success of the treatment was evaluated at the end of four weeks.Total follow-up time was 3 months.The final assessment included an evaluation of changes in the ocular discomfort score, demodex count, eyelid hygiene conditions and side effects.A paired t-test was used for comparison of data before and after the treatment.Results One hundred eighty of 240 patients (75.0%) had complete relief of symptoms after treatment, and 38(15.8%) had significant improvement.The mean ocular discomfort score was 8.2±3.2 before treatment, which dropped to 0.3±0.8 after treatment (t=12.28, P<0.01).The eyelids of 212 patients (88.3%) became free of dandruff.The demodex count was 6.2±4.8 for every four eyelashes before treatment and declined to 0.7±0.6 for every four eyelashes after treatment (t=6.96, P<0.01).None of the patients experienced an allergic reaction or had adverse reactions during or after the treatment.Conclusion Lid scrub with 5% tea tree oil ointment can effectively relieve the symptoms of scaly blepharitis, which is associated with demodex infestation and greatly diminishes the number of demodex mites.This shows that the treatment is safe and effective.%目的 探讨5%茶树油眼膏治疗蠕形螨相关鳞屑性睑缘炎的临床疗效.方法 前瞻性临床研究.选择2007年6月至2013年6

  15. 糖皮质激素与他克莫司软膏治疗成人特应性皮炎的不良反应对比分析%Comparative analysis of adverse drug reactions caused by Glucocorticoid and Tacrolimus Ointment in the treatment of atopic dermatitis

    Institute of Scientific and Technical Information of China (English)

    黄小玲; 赖永珲; 林渡娣; 邱梓; 杨春燕; 邓诗清; 黄福新

    2011-01-01

    Objective: To compare the adverse drug reactions (ADR) caused by Glucocorticoid (GC) and Tacrolimus Ointment in the treatment of atopic dermatitis (AD), and evaluate the safety of the two drugs in the treatment of AD in clinic.Methods: A total of 100 patients with adult AD were randomly divided into GC group and Tacrolimus Ointment group,with 50 patients in each group.Patients in the two groups were respectively given GC and Tacrolimus Oinment for extemal use, and the efficacy as well as the occurrence of ADR in the two groups were observed and compared.Results: The total efFective rate of Tacrolimus Ointment group was significantly higher than that of the GC group (94.0% vs 78.0 %, P<0.05),the incidence of drug-related ADR was obviously lower than that of GC group (24.0% vs 40.0%, P<0.01), and the main ADR were local skin pruritus and pricking pain, all the clinical manifestations of ADR were mild and could be relieved without special treatment.GC group had more and severe clinical manifestations of ADR than those of Tacrolimus Ointment group, the main ADR were local dermatrophia, 8teroid acne, crinosity, steroid-induced flush, local skin pricking pain,buming sensation and so on, and needed symptomatic treatment.Conclusion: Tacrolimus Ointment has a better efficacy in the treatment of AD, the ADR are less and mild, the medication is safe and is worthy of application in clinic.%目的:比较糖皮质激素与他克莫司软膏治疗成人特应性皮炎(AD)发生不良反应的情况,评价二者治疗成人AD的安全性.方法:将100例成人AD患者随机分为糖皮质激素组和他克莫司软膏组,每组50例,分别给予外用糖皮质激素及他克莫司软膏治疗,观察并比较两组治疗成人AD的疗效及不良反应发生情况.结果:他克莫司软膏组总有效率高于糖皮质激素组(94.0%对78.0%,P<0.05),药物相关不良反应的发生率明显低于糖皮质激素组(24.0%对40.0%,P<0.01),主要不良反应为局部瘙

  16. Efficacy of combination therapy of dual wavelength Intense Pulsed Light and topical tacrolimus 0.1%ointment on treatment of rosacea%双波长强脉冲光联合0.1%他克莫司软膏治疗玫瑰痤疮疗效观察

    Institute of Scientific and Technical Information of China (English)

    万建勣; 肖洁平; 丁街生; 董秀芹

    2015-01-01

    Objective To evaluate the efficacy and safety of combination therapy of dual wavelength Intense Pulsed Light (IPL) and topical tacrolimus 0.1% ointment on treatment of rosacea. Methods Sixty-five subjects with erythematotelangiectatic rosacea or papulopustular rosacea were divided randomly into three groups. Group combination and group IPL were treated with 3 sessions of IPL at 2 weeks intervals, group combination and group TLM received tacrolimus 0.1%ointment twice daily for 8 weeks.Scores and side effects were evaluated and recorded by physician's assessment by two blinded dermatologists for 8 weeks. Results At 8th week, the decline in severity scores of the group combination,IPL and TLM was 7.76 ± 2.37,7.41 ± 2.06 and 5.40 ± 2.92 respectively,the differences between the three groups were significant (P<0.05).Total efficiencies of the group combination, group IPL and group TLM were 84.85,82.35% and 42.11% respectively.No serious adverse event was observed in either group. Conclusion IPL and tacrolimus 0.1% ointment are both safe for treatment of rosacea,IPL improves rosacea better than tacrolimus 0.1% ointment for 8 weeks'treatment,short-term combination therapy of IPL and tacrolimus 0.1% ointment on rosacea has no clear advantage over that of IPL.%目的:观察双波长强脉冲光(intense pulsed light,IPL)联合0.1%他克莫司软膏治疗玫瑰痤疮的疗效及安全性。方法:将65例I型及II型玫瑰痤疮患者随机分为联合组、IPL组及他克莫司(Tacrolimus,TLM)治疗组。联合组及IPL组采用双波长IPL治疗,每2周1次,共治疗3次,同时,联合组及TLM组采用0.1%他克莫司软膏,每日2次,连续8周。由两位盲态医生对患者的皮损评分并记录不良反应,共8周。结果:研究第8周,联合组、IPL组及TLM组治疗前后积分差值分别为7.76±2.37、7.41±2.06及5.40±2.92,差异有显著性(P<0.05);三组总有效率分别为84.85%、82.35%及46.66%;均未见严

  17. 痔疮消炎膏抗炎镇痛及促溃疡面愈合的药效学研究%Pharmacodynamic studies on anti-inflammatory and analgesic action and improving heal to ulcer of the hemorrhoids anti-inflammatory ointment

    Institute of Scientific and Technical Information of China (English)

    叶绿萍; 庞黎明; 李德钢; 马儒清

    2014-01-01

    目的:从抗炎消肿、镇痛及促溃疡面愈合三个方面,对痔疮消炎膏进行药效学评价,为痔疮消炎膏的临床评价提供实验依据。方法观察痔疮消炎膏高、中、低剂量对二甲苯致小鼠耳廓肿胀的抗炎消肿作用、对小鼠痛阈的影响、对冰醋酸致大鼠肛门溃疡面愈合的影响。结果痔疮消炎膏高、中二个剂量均能明显抑制二甲苯所致的耳部炎症反应,而且其高剂量组的抑制作用优于马应龙麝香痔疮膏;局部涂药高、中、低浓度均可明显提高小鼠热板法致痛的痛阈值而产生较强的镇痛作用;对冰醋酸造模所致肛门溃疡的大鼠,高浓度组可以明显促进小鼠皮肤溃疡的愈合,缩小皮肤溃疡面积。结论痔疮消炎膏具有明显的抗炎消肿、镇痛、促进溃疡面愈合的功效,是外治法治疗痔疮的优良的外用药。%Objective To evaluate the efficacy of hemorrhoids anti-inflammatory ointment on the basis of the anti-inflammation, analgesia and ulcer healing promoting , and to provide experimental basis for clinical evaluation for hemorrhoids anti-inflammatory ointment .Methods To observe the hemorrhoids anti-inflammatory cream, in high, middle,low dose on xylene induced mouse auricle swelling effect , hot plate method for mice analgesia experiment effect on the pain threshold of mice , injection of acetic acid induced rat anal ulcer surface healing .Results Hemorrhoids Anti-inflammatory Ointment , in high, middle dose on xylene induced mouse auricle swelling effect significantly inhibited the mice ear edema .The inhibitory effect of high dose group was better than Mayinglong Musk Hemorrhoids Ointment .And the three group of mice hot-plate procedures all can remarkably increasesd mice pain threshold .The high dose group can im-prove to heal the ulcer skin of mice obviously and to reduce the area of ulcer about the Glacial acetic acid lead to anal ulcer in rats .Conclusion The

  18. Comparison on Influence of Huangbai Acne Ointment Prepared Different Techniques for Structure of Sebaceous Glands of Golden Hamster%不同工艺黄白痤疮膏对金黄地鼠皮脂腺斑组织结构的影响比较

    Institute of Scientific and Technical Information of China (English)

    彭学著; 钟湘云; 杨惠; 陈卫平; 刘百祥; 曾蕾

    2012-01-01

    Objective: To optimize the preparation technology of Huangbai acne ointment and investigate the effects of Huangbai acne ointment prepared by different techniques on structure of sebaceous glands. Methods: The sebaceous gland spots of adult male Syrian hamster flank organ served as the animal model and were randomly divided into six groups. No1-6 ointments were applied to sebaceous gland spot of six groups respectively for 30 days, HE staining to observe the structure of sebaceous glands, the analysis of computer microphotography was used to collect the OD value of all spots and the results were statistically analyzed. Results: The MOD and IOD of gland spots were used as the evaluating criterion, the difference between test groups and control group was significant(P<0.01). Compared with the positive control group, there was significant difference between the Tuckahoe polysaccharide group and decoloration group(P<0.05). Conclusion: The effect of Huangbai acne ointment prepared using water extraction, water extraction and alcohol precipitation and alcohol extraction were the best, and the effect of ointment by water extraction then decolorize was the weakest.%目的:考察不同制备工艺黄白痤疮膏对金黄地鼠皮脂腺斑组织结构的影响度,优选黄白痤疮膏的制备工艺.方法:选用成年雄性金黄地鼠侧腹部皮脂腺斑作为动物模型,随机分成6组,分别采用1-6号软膏涂敷皮脂腺斑30 d,取皮脂腺斑组织做HE染色切片,用计算机显微图像分析系统采集各斑块的光密度值,做统计分析.结果:以皮脂腺斑的平均光密度值和累计光密度值为指标,各试验组与空白对照组相比较,差异均有统计学意义(P<0.01);茯苓粗多糖组和脱色组与阳性对照组相比较,差异有统计学意义(P<0.05).结论:水提法、水提醇沉法和醇提法制备的黄白痤疮膏作用最强、疗效最好;而水提后脱色处理的药膏作用最弱.

  19. 回阳生肌膏对慢性皮肤溃疡形态变化的初步研究%A preliminary study on Huiyang Shengji Ointment to chronic skin ulcers of the morphological changes

    Institute of Scientific and Technical Information of China (English)

    王广宇; 王伏声; 丁毅; 康煜冬; 李勇; 王雨; 董雨; 徐旭英

    2014-01-01

    目的:探讨回阳生肌膏治疗慢性皮肤溃疡腐肉、肉芽、脓液及组织HE染色形态变化规律。方法收集首都医科大学附属北京中医医院2012年11月~2013年11月40例局部辨证为寒湿凝滞证慢性疮面患者,随机分为两组,治疗组应用回阳生肌膏纱条,对照组按照常规方法进行。观察两组治疗前后疮面形态评分和治疗前后皮下组织HE染色变化情况。结果对照组总的评分治疗前为(29.1±5.7)分,治疗组为(28.4±6.1)分,差异无统计学意义(P>0.05);对照组治疗后为(25.7±5.4)分,与治疗前比较,差异有统计学意义(P 0.05); the total score of the control group was (25.7±5.4) scores after the treatment, compared with the control group, the difference was statistically significant (P<0.05). The total score of the treatment group was (22.9±6.8) scores, compared with the treat-ment group, the difference was statistically significant (P < 0.05). The comparison between the control group and the treatment group showed that, the difference was statistically significant (P<0.05). The subcutaneous tissue HE staining showed that there were more inflammatory cells before treatment, endothelial cells and fibroblasts were less and thin, and they sprawled out in some areas, collagen fibers were dyed pale; there were less inflammatory cells after treatment, endothelial cells and fibroblasts were more and well-stacked, they distribute regularly, ollagen fibers were dyed dark. Healing trend was better in the treatment group than in the control group. Conclusion Warming Yang and Invigorating Qi, the main effect of Huiyang Shengji Ointment, can make chronic skin ulcer w ound turn "Yin" into "Yang", and turn "Static" into "Dynamic", so that the speed of wound healing will be accelerated.

  20. Determination of camphor, synthetic borneol, menthol in HanBi Ointment by GC%气相色谱法测定寒痹软膏中樟脑、冰片和薄荷脑的含量

    Institute of Scientific and Technical Information of China (English)

    郑伟强

    2014-01-01

    目的:建立测定寒痹软膏中樟脑、冰片、薄荷脑含量的方法。方法采用气相色谱法,毛细管柱为 ZB-Wax(30m ×0.25mm ×0.5μm),萘为内标物,程序升温,FID检测器。结果樟脑、冰片、薄荷脑分别在0.3209~0.6417mg· mL -1、0.2414~0.4828mg· mL -1、0.2392~0.4784mg · mL -1范围内呈良好线性关系。平均回收率分别为:樟脑102.54%,RSD 为1.02%;冰片98.81%,RSD 为1.05%;薄荷脑102.13%,RSD 为1.53%。结论本方法简便、快速、准确、重复性好,可同时测定寒痹软膏中樟脑、冰片和薄荷脑的含量。%OBJECTIVE To set up a method for the determination of camphor ,synthetic bomeolmenthol in Han-bi Ointment.METHODS camphor , synthetic bomeol , menthol wasdetermined by GC.A capillary column ZB-Wax (30m ×0.25mm ×0.5μm) was used,sequential increase of temperature programming ,FID detector.RESULTS camphor , syntheticborneol , menthol presented a good linear correlation within a range of 0.3209 ~0.6417 mg · mL-1、0.2414~0.4828 mg· mL-1、0.2392~0.4784 mg· mL-1.The average recovery of camphor ,synthetic bome-ol and menthol was 102.54%( RSD =1.02%)、98.81%( RSD =1.05%)、102.13%( RSD =1.53%).CONCLUSION This method is simple ,reliable and good repeatability.

  1. Determination of the Content of Borneol、Menthol、Camphor in Sanhong Ointment by GC%气相色谱法测定三红软膏中冰片、薄荷脑、樟脑的含量

    Institute of Scientific and Technical Information of China (English)

    邓康程

    2016-01-01

    目的:建立气相色谱法测定粉三红软膏中冰片、薄荷脑、樟脑的含量。方法以萘为内标物,选用ZB-Wax毛细管柱(30m ×0.25mm ×0.5μm);载气为:氮气、氢气、空气;FID检测器;采用升温程序与分流进样。结果冰片、薄荷脑、樟脑的线性关系良好,冰片、薄荷脑、樟脑的平均回收率分别为98.81%、102.04%、102.54%,RSD分别为1.53%、1.05%、1.02%。结论该方法准确可靠、精密度高、重现性好,可用于三红软膏中冰片、薄荷脑、樟脑的含量测定。%ABSTRACT:OBJECTIVE To establish a GC method for determination of borneol、menthol、camphor in Shang-hong Ointment.METHODS Naphthalene was used for the internal standard .The GC system consisted of ZB-Wax capillary column (30 m ×0.25 mm ×0.5μm);nitrogen、hydrogen、air as the carrier gas;FID as the detector;Using the temperature program and Split injection .RESULTS borneol、menthol、camphor showed a good linear relation-ship.The average recovery was 98.81%、102.04%、102.54%,RSD was 1.53%、1.05%、1.02%.CONCLUSION The method is accurate、reliable、high precision、good repeatability and can be used for the determination of borne-ol、menthol、camphor in Shanghong Ointmen .

  2. Effect of periocline ointment on fixed orthodontic patients with gingivitis%龈炎病人戴固定矫治器前用派力奥治疗的临床效果

    Institute of Scientific and Technical Information of China (English)

    王雪梅; 薄磊; 王菁; 张菊梅; 曹宝成; 余占海

    2011-01-01

    目的:对患有牙龈炎的病人在固定矫治前使用派丽奥软膏治疗,评价其在矫治过程中的疗效.方法:选择在我院进行正畸治疗,年龄<18岁并患有牙龈炎的病人60名,首先进行龈上洁治,然后随机分为3组:派丽奥治疗组(A组),碘甘油治疗组(B组),空白对照组(C组),比较正畸治疗前以及治疗中1、3、6个月3组牙周指标( PLI,GI,GD).结果:A组的GI、PLI、GD与B组相比,在1、3个月有显著差异(P<0.05)与C组相比,在1、3、6个月有显著差异(P<0.05).结论:对患有牙龈炎的正畸病人在正畸前使用派丽奥治疗,正畸治疗的1~3个月内,能有效减轻牙龈炎.%AIM: To evaluate the effect of periocline ointment on gingivitis when fixed orthodontic was ap-plied. METHODS: Sixty orthodontic patients with ginqivitis were randomly divided into 3 groups, supragingival scaling plus periocline (group A) , supragingival scaling plus iodine glycerin ( group B) and supragingival scaling only (group C). Plaque index (PLI) , gingival index (GI) and gingival groove depth (GD) were measured and analyzed before and during orthodontic treatment. RESULTS; Periocline plays a good treatment role for group A, the GI, PLI and GD clinical indexes of group A were better than those of group B and C, and the effect was significantly different (P = 0. 000) from group C after 1, 3 and 6 months. Moreover, after 1 and 3 months, the treatment effect on group A was statistical different (P =0.0005) from traditional B group. CONCLUSION; Periocline application can significantly reduce the progress of gingivitis for orthodontic patients.

  3. Application of Minocycline Hydrochloride Ointment in the Treatment of Periodontitis%盐酸米诺环素软膏在牙周炎治疗中的应用分析

    Institute of Scientific and Technical Information of China (English)

    徐波

    2015-01-01

    Objective The clinical efficacy of Periocline(Minocycline hydrochloride ointment) in treatment of periodontitis is to be analyzed.MethodsChoose 91 patients with periodontitis who are treated in hospital from September 2013 to September 2014 and separate them into iodine glycerin group and periocline group,and then compare the PD(Periodontal probing depth),PLI(Plaque Index),SBI(Sulcus bleeding index)data changes and treatment efficacy of two groups before and after treatment.Results The numerical data of PD,PLI,SBI in periocline group are much lower than iodine glycerin group,however,the treatment efficiency in periocline group are much higher than iodine glycerin group,and such a treatment differential has statistic value(P<0.05).Conclusion Periocline treatment is effective to improve patients’ clinical symptoms and their periodontitis index. And it is simple,economic and safe to use with high efficiency,therefore,it is quite worthwhile to be promoted.%目的分析牙周炎治疗中应用派力奥(盐酸米诺环素软膏)的临床疗效。方法选取2013年9月~2014年9月间我院收治的牙周炎患者91例,分为碘甘油组与派力奥组,对比治疗前后两组PD(牙周探诊深度)、PLI(菌斑指数)、SBI(龈沟出血指数)变化与临床效果。结果派力奥组患者PD、PLI、SBI值与碘甘油组相比明显较低,总有效率(95.74%)相对较高,两组临床疗效差异显著,有统计学意义(P<0.05)。结论牙周炎治疗中应用派力奥可以有效改善临床症状与牙周指数,简便经济,有效安全。

  4. Observation on the Therapeutic Effect of External Application of Detumescence Ointment on Early Local Swollen Ankle Sprains%观察消肿膏外敷对早期踝关节扭伤局部肿胀的疗效

    Institute of Scientific and Technical Information of China (English)

    史志良

    2016-01-01

    Objective To observe the therapeutic effect of external application of swelling paste on early ankle swelling.Methods A total of 80 patients with local swelling of ankle joint were treated in our hospital,and the patients were randomly divided into groups. Control group of 40 patients with ice treatment. Observation group (40 cases) to detumescence ointment in the treatment of and U type resin bandage for external fixation support,compared two groups of patients with clinical curative effect.ResultsThe total effective rate of the observation group and the control group were 95% and 75%,there were significant differences between the two groups(P<0.05). Conclusion The external application of swelling cream has a better effect on early ankle sprain swelling,ice treatment is better than the traditional treatment.%目的:观察消肿膏外敷对早期踝关节扭伤局部肿胀的治疗效果。方法选取我院收治的早期踝关节扭伤局部肿胀患者共80例,随机分组处理。对照组40例进行冰敷治疗;观察组40例以消肿膏外敷治疗,且以U型树脂绷带进行托外固定,比较两组患者的临床疗效。结果观察组与对照组患者的治疗总有效率分别为95%及75%,组间比较差异有统计学意义(P<0.05)。结论消肿膏外敷对早期踝关节扭伤局部肿胀具有较好的效果,优于传统的冰敷治疗。

  5. Clinical Study of Acute Gouty Arthritis of Damp-Heat Accumulation Type Treated with Sanhuang Zhongtong Ointment and Xinhuang Tablet%三黄肿痛膏合新癀片治疗湿热蕴结型急性痛风性关节炎的临床观察

    Institute of Scientific and Technical Information of China (English)

    杨金颖

    2015-01-01

    Objective To observe the effect of Sanhuang Zhongtong ointment and Xinhuang tablet in the treatment of Damp-Heat accumulation type of acute gouty arthritis. Methods Chose 60 cases of patients with Damp-Heat accumulation type of acute gouty arthritis and divided into treatment group and control group, 30 cases in the control group were treated with ibuprofen. 30 cases in the control group were treated with Sanhuang Zhongtong ointment and Xinhuang tablet. Observed the clinical symptoms, signs and the change of blood uric acid in two groups. Results The total effective rate in treatment group was 90%, in control group was 66.67%. Comparing the two groups, the difference was statistically significant (P<0.05). After treatment, blood uric acid values in treatment group were signiifcantly lower than the control group, the difference was statistically significant (P<0.05). Conclusion The effect of Sanhuang Zhongtong ointment and Xinhuang tablet in treatment of acute gouty arthritis curative has good effect and less side effect.%目的:观察三黄肿痛膏合新癀片治疗湿热蕴结型急性痛风性关节炎的临床疗效。方法共选取60例患者,随机分为治疗组和对照组。对照组30例采用布洛芬治疗;治疗组30例采用三黄肿痛膏外敷合新癀片内服治疗。主要观察临床症状、体征及血尿酸的变化。结果治疗组总有效率为90%,对照组总有效率为66.67%。两组比较,差异有统计学意义(P<0.05)。治疗后治疗组的血尿酸值低于对照组,差异有统计学意义(P<0.05)。结论三黄肿痛膏联合新癀片治疗急性痛风性关节炎疗效好,副作用小。

  6. Effect and nursing experience of hirudoid ointment treatment for the internal arteriovenous fistula in patients with hemodialysis%多磺酸粘多糖乳膏治疗血液透析患者动静脉内瘘的疗效及护理

    Institute of Scientific and Technical Information of China (English)

    凌扣荣

    2013-01-01

    目的 探讨多磺酸粘多糖乳膏治疗血液透析患者动静脉内瘘的疗效及护理体会.方法 将60例血液透析动静脉内瘘患者按照随机数字法随机分为对照组和观察组各30例,对照组给予常规治疗及护理,观察组在常规治疗基础上,给予多磺酸粘多糖乳膏及相应护理干预.观察和比较两组患者临床疗效.结果 对照组治疗的总有效率为43.3%,观察组为93.3%,两组比较,差异有统计学意义(x2=17.33,P<0.05).结论 对于血液透析动静脉内瘘患者,多磺酸粘多糖乳膏及相应护理干预能显著提高临床疗效,改善患者的预后,值得临床推广.%Objective To discuss the effect and nursing experience of hirudoid ointment treatment for the internal arteriovenous fistula in patients with hemodialysis.Methods Totals of 60 hemodialysis patients with internal arteriovenous fistula were randomly divided into the control group and the observation group,each with 30 cases.The control group received conventional treatment and nursing while the observation group received hirudoid ointment treatment and related nursing intervention in addition.Two groups' clinical effect was observed and compared.Results Effective rate was 43.3% in the control group and 93.3% in the observation group,and the difference was statistically significant (x2 =17.33,P < 0.05).Conclusions Hirudoid ointment treatment and related nursing intervention for hemodialysis patients with internal arteriovenous fistula can significantly improve clinical effect and patients' prognosis quality,thus is worthy of clinical promotion.

  7. Clinical Observation on Treatment of Knee Osteoarthritis by Only Sodium Hyaluronate and Its Combination with JieDu XiaoYu Ointment%玻璃酸钠单独使用与联合解毒消瘀膏治疗膝骨性关节炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    王想福; 石瑞芳; 武纪玲; 赵军; 孔令俊; 谭小花

    2015-01-01

    Objective:To observe the clinical curative effect of JieDu XiaoYu ointment combined with sodi-umhyaluronate on knee osteoarthritis. Methods: All 60 patients were randomized into the research and control groups with 30 cases in each, sodium hyaluronate was injected to patients of control group in articular cavity while the combination of JieDu XiaoYu ointment with sodium hyaluronate were administered to the cases of research group;one course of treatment is 4 weeks in both groups and the therapeutic effects presented from osteoarthritis indexes were assessed by WOMAC. Results: The total effective rate in research group was 83.33% significantly better than that of 53.33%in control group (P<0.05). Conclusion:The curative effect of JieDu XiaoYu ointment combined with sodium hyaluronate in treating knee osteoarthritis is superior to that of the pure injection of sodium hyaluronate in articular cavity.%目的:观察解毒消瘀膏联合玻璃酸钠治疗膝关节骨性关节炎的临床疗效。方法:将门诊就诊的膝关节骨性关节炎患者60例随机分为对照组和研究组各30例,对照组采用玻璃酸钠关节腔注射治疗,研究组采用解毒消瘀膏膝关节外敷配合玻璃酸钠关节腔注射治疗,2组治疗4周为1个疗程,采用WOMAC骨性关节炎指数评分评价疗效。结果:研究组总有效率为83.33%,疗效明显优于对照组的53.33%(P<0.05)。结论:解毒消瘀膏外敷配合玻璃酸钠关节腔注射治疗膝关节炎疗效优于单纯采用玻璃酸钠关节腔注射。

  8. 龙血竭联合马应龙麝香痔疮膏治疗Ⅲ期压疮的效果%Effect of Dragon' s Blood combined with Musk hemorrhoids ointment on patients with pressure sore of stage Ⅲ

    Institute of Scientific and Technical Information of China (English)

    黎红梅; 李敏; 刘建平; 辜红娟

    2013-01-01

    Objective To explore the curative effect of dragon's blood combined with Musk Hemorrhoids Ointment on the treatment of stage Ⅲ pressure sore patients.Methods Totals of 76 cases of Ⅲ stage pressure sore patients were randomly divided into observation group and control group,with 38 cases in each group,two groups of local same method to treat the wound.The observation group was treated with dragon's blood,Musk Hemorrhoids Ointment to tune into a paste coating wound,operation incision sterile protective film fixed.While control group treated with moist burn ointment coating wound,sterile gauze bandage fixed.Therapeutic effect and healing time was compared between the two groups.Results In the observation group and the control group,the total effective rates were 100% and 78.95%,and the difference was statistically significant (x2 =3.945,P <0.05).The healing time of observation group and control group respectively were (13.56 ±4.35) days and (21.45 ± 3.47) days,and the difference was statistically significant (t =2.365,P< 0.01).Conclusions The dragon's blood combined with Musk Hemorrhoids Ointment for external application in the treatment of Ⅲ patients with satisfactory results,which can shorten the treatment time,improve the cure rate.%目的 探讨龙血竭联合马应龙麝香痔疮膏治疗Ⅲ期压疮的疗效.方法 将76例Ⅲ期压疮患者按随机数字余数法分为观察组和对照组各38例,两组局部采用相同方法处理创面,观察组采用龙血竭、马应龙麝香痔疮膏调成糊状涂敷创面,手术切口无菌保护膜固定;对照组采用湿润烧伤膏涂敷创面,无菌纱布包扎固定,比较两组患者的治疗效果及治愈时间.结果 观察组和对照组总有效率分别为100%,78.95%,两组比较差异有统计学意义(x2=3.945,P均<0.05).观察组与对照组患者Ⅲ期压疮治愈时间分别为(13.56±4.35)d,(21.45±3.47)d,观察组优于对照组,两组比较差异有统计学意义(t=2

  9. Curative effect of narrow-band ultraviolet combined with compound clobetasol propionate ointment on psoriasis vulgaris%中波紫外线联合复方丙酸氯倍他索软膏治疗寻常性银屑病疗效观察

    Institute of Scientific and Technical Information of China (English)

    李小静; 李志锋; 王久江; 李显平

    2015-01-01

    目的:观察窄谱中波紫外线联合复方丙酸氯倍他索软膏治疗寻常性银屑病的临床疗效和安全性。方法采用随机对照方法,将寻常性银屑病患者60例随机分为试验组和对照组。试验组采用中波紫外线(narrow-band ultraviolet,NB-UVB)照射,3次/周,复方丙酸氯倍他索软膏每晚外用1次;对照组采用复方丙酸氯倍他索软膏每晚外用1次。疗程均为8周。观察治疗2、4、8周时的疗效及不良反应。结果治疗后,2组患者银屑病面积和严重程度指数评分均较治疗前降低,试验组降低程度较对照组明显。治疗2、4、8周试验组疗效均好于对照组,且随治疗时间延长,疗效明显增加。2组不良反应发生率比较差异无统计学意义。结论窄谱中波紫外线联合复方丙酸氯倍他索软膏治疗寻常性银屑病疗效确切,安全性好。%Objective To assess the efficacy and safety of narrow-band ultraviolet(UVB) combined with compound clobetasol propionate ointment for the treatment of psoriasis vulgaris. Methods A randomized clinical trial was conducted.Totally 60 patients with psoriasis vulgaris were randomly divided into the experiment group(treated with NB-UVB plus topical compound clobetasol propionate ointment once daily in the evening ) and control group (treated with compound clobetasol propionate ointment once daily only).The treatment course lasted for eight weeks.The efficiency and adverse reactions were evaluated at the baseline,as well as 2,4 and 8 weeks after treatment.Results After treatment,psoriasis area and severity index of two groups were lower than before,also the degree of experimental group decreased significantly compared with that of control group.After the treatment for 2,4,8 weeks,the efficacy of experimental group was better than that of control group,and with the time,the effect significantly increased. Adverse reactions showed no significant difference between two

  10. 复方丙酸氯倍他索软膏联合5%水杨酸软膏外用治疗慢性湿疹疗效观察%Analysis of clinical efifcacy of compound clobetasol propionate and 5% salicylic acid ointment for chronic eczema

    Institute of Scientific and Technical Information of China (English)

    杨军; 毕鸣晔

    2016-01-01

    ObjectiveTo explore the clinical efifcacy and safety of compound clobetasol propionate combined with 5% salicylic acid ointment for chronic eczema.MethodsTotal 134 patients with chronic eczema were divided into three groups. Seventy-four patients in the treatment group were treated with clobetasol propionate and 5% salicylic acid ointment, 30 patients in control group 1 were treated with clobetasol propionate, and 30 patients in control group 2 were treated with 5% salicylic acid ointment. Treatments were given twice daily, and the therapeutic effects were evaluated at 2, 4 and 6 weeks.ResultThe effective rates of the treatment group were both higher than that of the control groups (P<0.05), and the effective rates of the control group 1 were higher than that of the control group2(P<0.05).ConclusionCompound clobetasol propionate combined with 5% salicylic acid ointment can be considered as one kind of effective and safe treatment modality for chronic eczema with short protocol and good compliance.%目的:评价复方丙酸氯倍他索软膏联合5%水杨酸软膏治疗慢性湿疹的临床疗效及安全性。方法选择我院门诊2012年1月—2013年6月收治的134例慢性湿疹患者,按照患者自愿的原则,将患者分为试验组(74例),对照组1(30例)和对照组2(30例)。对照组1单独给予复方丙酸氯倍他索软膏外用,对照组2单独给予5%水杨酸软膏外用,试验组采用两种药物联合外用,分别于治疗后2周、4周、6周观察疗效,并进行统计学分析。结果治疗2周、4周、6周时,试验组有效率均优于两个对照组,而两个对照组中对照组1的疗效也优于对照组2,差异均具有统计学意义(P<0.05)。结论复方丙酸氯倍他索软膏联合5%水杨酸软膏外用治疗慢性湿疹临床疗效显著,疗程短,患者依从性好。

  11. 烧伤膏外用对浅Ⅱ度水火烫伤创面愈后色素沉着的影响%Effects of burn ointment external application on the hyperpigmentation after healing wound of superficial Ⅱ degree burns of water and fire

    Institute of Scientific and Technical Information of China (English)

    黄树林; 徐茂奇

    2011-01-01

    Objective To investigate the effects of burn ointment external application on the hyperpigmenta-tion after healing wound of superficial II degree burns of water and fire. Methods 84 patients with burns of water and fire were randomly divided into two groups. Patients in two groups received basic therapy including debridement and antibiotics. 40 cases in treatment group received external application of burn ointment No. I at early period and burn ointment No. II at late period. Control group received external application of silver sulfadiazine cream. The frequency of dressing in two groups was a time every other day, a week for a course of treatment. After two courses wound healing time were recorded. The status of hyperpigmentation after wound healing was observed three months later. The ratio of hyperpigmentation area and burn area was calculated. Results Wound healing time, the incidence of hyperpigmentation and the ratio of hyperpigmentation area and burn area in the treatment group (13. 63 + 1.51 d, 20.0% , 15.25 ±3.80) were lower than those in control group (14.70 ±1.34 d, 40.9% , 25.60 ±5.40, P <0. 01, P <0.05). Conclusion External application of burn ointment can significantly reduce healing time, prevent and reduce hyperpigmentation.%目的 观察烧伤膏外用对浅Ⅱ度水火烫伤创面愈后色素沉着的影响.方法 将84例水火烫伤患者随机分为2组,2组均予常规清创、抗感染等基础治疗,治疗组40例早期予烧伤膏Ⅰ号外用,后期予烧伤膏Ⅱ号外用;对照组44例加磺胺嘧啶银乳膏外用治疗.2组均隔日换药1次,1周为1个疗程,治疗2个疗程.统计2组创面修复时间.嘱患者3个月后复诊,观察记录是否发生创面修复后色素沉着,统计色素沉着面积/烧伤面积值.结果 治疗组40例,创面修复时间( 13.63±1.51)d,色素沉着发生率20.0% (8/40),色素沉着面积/烧伤面积为5% ~ 30%,平均(15.25±3.80)%;对照组44例,创面修复时间(14.70±1

  12. The observation of effect of Mayinglong hemorrhoids ointment combined with ultrashort wave therapy on the dehiscence wound of lateral episiotomy%马应龙麝香痔疮膏联合超短波治疗会阴侧切裂开伤口的疗效观察

    Institute of Scientific and Technical Information of China (English)

    单龙; 刘晓雁; 段丽君; 罗亚莉; 孙晓彤

    2015-01-01

    Objective To explore the effect of Mayinglong hemorrhoids ointment combined with ultrashort wave on dehiscence wound of lateral episiotomy .Methods 105 patients with dehiscence wound of lateral episiotomy in People's Hospital of Gansu Province from 2008 to 2013 were randomly divided into two groups , patients in observation group ( 53 cases ) were treated by Mayinglong hemorrhoids ointment combined with ultrashort wave , patients in control group ( 52 cases ) were treated by debridement disinfection combined with erythromycin eye ointment external application .The healing time , healing rate and infection rate were compared between two groups.Results The healing time and infection rate (0) of observation group were lower than that of control group [11.54 %(6/52)], healing rate of observation group[100 %(53/53)] were higher than that of control group [71.15 %(37/52)](P<0.05). Conclusion Mayinglong hemorrhoids ointment combined with ultrashort wave had a confirmative effect on dehiscence wound of lateral episiotomy, and has benefits of simple , short time, fewer complications .%目的:探讨马应龙痔疮膏联合超短波对会阴侧切裂开伤口的治疗效果。方法回顾性分析2008~2013年甘肃省人民医院105例会阴侧切后伤口裂开患者的临床资料,按照不同治疗方法分为观察组53例,对照组52例,观察组患者采用马应龙痔疮膏联合超短波治疗,对照组患者采用单纯清创消毒加红霉素眼药膏外敷。比较两组伤口愈合时间、愈合率及感染率。结果观察组患者愈合时间、感染率(0)明显低于对照组[11.54%(6/52)],伤口愈合率[100%(53/53)]高于对照组[71.15%(37/52)](P<0.05)。结论马应龙痔疮膏联合超短波对产科会阴侧切裂开伤口及感染伤口促愈合治疗效果明确,方法简单,时间短,并发症少。

  13. 生肌玉红胶原海绵促进胶原合成与组织愈合的研究%Experimental Research on Collagen Sponge Loading with Shengji Yuhong Ointment for Improving Synthesis of Type Ⅰ and Ⅲ Collagen and Wound Heating

    Institute of Scientific and Technical Information of China (English)

    缪雪华; 张宇轩; 陈运; 周勇; 黄金龙; 姚昶

    2012-01-01

    目的 探讨生肌玉红胶原海绵促进肉芽生长与创面愈合的可能机理.方法 修饰后胶原海绵、生肌玉红膏、生肌玉红胶原海绵敷于大鼠背部机械性皮肤全层创面,控制组以凡士林纱布覆盖,于造模后3、7、14d,测试创面愈合率、肉芽组织中Ⅰ、Ⅲ胶原含量、bFGF阳性细胞数、羟脯氨酸含量.结果 造模第3天时,羟脯氨酸含量、bFGF阳性细胞数、I型胶原含量,生肌玉红胶原海绵组均显著高于生肌玉红膏组及控制组;第7天时,实验组各指标均显著高于控制组,其中创面愈合率、Ⅰ型胶原含量、bFGF阳性细胞数、羟脯氨酸含量,生肌玉红胶原海绵组显著高于生肌玉红膏组;第14天时,Ⅰ型胶原含量各组无显著差异,创面愈合率、bFGF阳性细胞数、Ⅲ型胶原含量、羟脯氨酸含量,生肌玉红胶原海绵组显著高于控制组.结论 生肌玉红胶原海绵促进创面愈合与减少瘢痕形成的机制之一可能是调节创面bFGF水平与调节创面Ⅰ、Ⅲ型胶原含量实现的.%OBJECTIVE To explore the possible mechanisms of promoting granulation tissue growth and wounds healing by Shengji Yuhong collagen sponge. METHODS Applying modified collagen sponge, Shengji Yuhong Ointment and Shengji Yuhong collagen sponge on the full layers of mechanical wounds on the dorsum of each SD rat respectively, and the control group were covered with Vaseline gauze at the same time. The wounds healing rate, the amounts of type I and III collagen contents in the granulation tissue, the number of positive bGFG cells and contents of hydroxyproline were evaluated on the 3rd, 7th, 14th day during modeling. RESULTS On the 3rd day of modeling, the content of hydroxyproline, positive bFGF cells and I collagen in Shengji Yuhong collagen sponge group were obviously higher than Shengji Yuhong Ointment group and control group. On the 7th day, the indexes of each experimental group were significantly higher than

  14. 含汞中药外用制剂朱红膏对皮肤溃疡模型大鼠肾脏抗氧化能力的影响%Effect of Zhuhong ointment on renal antioxidant capability in skin ulcer model rats

    Institute of Scientific and Technical Information of China (English)

    王乐平; 李建荣; 董建勋; 罗玲; 贺蓉; 彭博; 徐启华; 林含; 张旭辉

    2012-01-01

    Objective: To study the effect of repeated administration of Zhuhong ointment on renal antioxidant capability of ulcerous skin in rats, in order to further discuss the mechanism of mercury contained in Zhuhong ointment on the antioxidant capability of kidney in skin ulcer rats. Method: Eighty SD rats were randomly divided into eight groups; Zhuhong ointment A, B, C, D, E (1. 219, 0.609, 0.305, 0.152, 0. 76 g ? Kg-1) groups, the vaseline group, the ulcer model group and the impairment control group. The levels of NAG and RBP of toxicity for early kidney tubular injury and T-AOC, SOD, GSH-PX and GSH in kidney were determined after consecutive administration for 14 days. Result: Compared with ulcer model group, the levels of RBP in groups A, B, C and D increased , while the levels of NAG increased only in the group A. The level of T-AOC increased in groups A, B and C. The level of T-SOD increased in the group E, while it dropped down greatly in the group A. The level of GSH-PX increased in groups A, B and C. The content of GSH increased in every dose groups. Conclusion: Antioxidant capacity in rats can be increased in a reasonable dose of Zhuhong ointment, but some antioxidant activity can be notably inhibited by with the increase of dose.%目的:研究经大鼠溃疡皮肤反复给予朱红膏对肾脏抗氧化能力的影响,进一步探讨朱红膏中汞经皮吸收作用于肾的机制.方法:将80只SD大鼠随机分8组:朱红膏A,B,C,D,E(含原药材1.219,0.609,0.305,0.152,0.076 g·kg-1)5个剂量组、基质组(凡士林)、溃疡模型组及皮肤破损组.连续给药14 d,测定尿液NAG,RBP水平及肾组织中T-AOC,SOD,GSH-PX,GSH水平.结果:与溃疡模型组比较,朱红膏A组NAG水平升高,A,B,C,D组RBP含量均明显升高;朱红膏A,B,C组T-AOC显著升高;朱红膏E组T-SOD活力升高;朱红膏A组T-SOD活力显著降低;朱红膏A,B,C组GSH-PX活力均明显升高;随剂量的增加,朱红膏各给药组GSH含量均明显升高.结论

  15. Simultaneous Determination of Benzoic Acid and Salicylic Acid in Compound Benz oic Acid Ointment by K-Factor UV Spectrophotometry%系数倍率紫外光谱法同时测定复方苯甲酸软膏中的苯甲酸和水杨酸的研究

    Institute of Scientific and Technical Information of China (English)

    吴咏梅; 叶芝祥; 蔡铎昌

    2001-01-01

    本文用系数倍率紫外光谱法同时测定了复方苯甲酸软膏中苯甲酸和水杨酸的含量,取得了满意的结果,苯甲酸测定回收率为99.33%—101.80%,水杨酸测定回收率为100.92%—105.46%。%The contents of benzoic acid and salicylic acid in compound benzoic acid ointment were simultaneously determined by K-factor UV spectrophotometry. The resu lt is satisfactory. The recoveries of benzoic acid and salicylic acid are in the range of 99.33%—101.80% and 100.92%—105.46%,respectively.

  16. 复方氟米松软膏对特应性皮炎患者经表皮水分丢失量的影响及其临床应用研究%Effect of compound flumetasone ointment on transepidermal water loss and its clinical application in patients with atopic dermatitis

    Institute of Scientific and Technical Information of China (English)

    戴鲡瑶; 董雪娇; 柯菲; 齐晓怡; 林茂; 涂彩霞

    2013-01-01

    Objective To evaluate the effect of salicylic acid on skin barrier function and the efficacy of salicylic acid combined with flumetasone ointment for the treatment of atopic dermatitis (AD).Methods Sixtyfour patients with AD (including 31 males and 33 females) aged 18 to 58 years were recruited into the present study.Four lesional areas of similar size and severity were selected at the similar body sites of both sides of each patient,and randomly classified into four groups to be topically treated with compound flumetasone ointment (containing 0.02% flumetasone and 3% salicylic acid,compound flumetasone group),flumetasone 0.02% ointment (flumetasone group),salicylic acid 3% ointment (salicylic acid group) and vehicle (control group),respectively;two normal skin areas were chosen from apparently normal skin on the similar body sites of both sides of each patient and topically treated with salicylic acid 3% ointment (salicylic acid group) and vehicle (control group) respectively.All of these preparations were applied twice a day for 3 weeks.Transepidermal water loss (TEWL) was measured by a Tewameter MPA580 (Courage & Khazaka,Germany) at the baseline as well as on week 1,2 and 3 after initiation of treatment.Symptom and sign scores were evaluated before and after the treatment.Meanwhile,two normal skin areas were selected on bilateral forearm of 30 healthy controls and treated with 3% salicylic acid ointment (salicylic acid group) and vehicle (control group) respectively twice a day for 3 weeks,and TEWL was measured before treatment as well as on week 1 and 3 after initiation of treatment.Results In the healthy controls,TEWL value showed no significant difference between the salicylic acid group and control group at any of these time points.As far as the lesional skin was concerned,no statistical difference was observed in TEWL value at the baseline between the four groups ((34.26 ± 20.82) vs.(33.02 ±16.71) vs.(34.16 ± 18.03) vs.(33.81 ± 17.11) g· m

  17. Avaliação da eficácia e segurança do tacrolimo pomada 0,03% no tratamento da dermatite atópica em pacientes pediátricos Evaluate of the efficacy and safety of tacrolimus ointment 0,03% to treat atopic dermatitis in pediatric patients

    Directory of Open Access Journals (Sweden)

    Bernardo Gontijo

    2008-12-01

    Full Text Available FUNDAMENTOS - Tacrolimo pomada é eficaz no tratamento da dermatite atópica. OBJETIVOS - Avaliar a eficácia e segurança do tacrolimo pomada 0,03% (Protopic® no tratamento de pacientes pediátricos com dermatite atópica. MÉTODOS - Estudo multicêntrico, aberto e não comparativo. Incluídos 174 pacientes (dois a 10 anoscom dermatite atópica. Utilizou-se tacrolimo duas vezes ao dia, por seis semanas. O critério primário de eficácia foi a melhora clínica > a 90% avaliada pelo médico (Escala de Avaliação Global da Resposta Clínica. Outros critérios de eficácia foram a redução no índice de área e gravidade do eczema (EASI, a redução do percentual de superfície corporal afetada (%BSA e a avaliação do prurido pelo paciente (escala analógica visual. Segurança foi avaliada pela ocorrência de eventos adversos relatados pelos pais e pacientes ou pelos investigadores. RESULTADOS - Trinta e três por cento dos pacientes apresentaram melhora clínica >90%. Quando avaliado o escore EASI, houve redução de 45,5% (primeira semana e 61,8% (sexta semana quando comparado com o basal (pBACKGROUND: Tacrolimus ointment has been shown to be effective in treatment of atopic dermatitis. OBJECTIVES: To evaluate the efficacy and safety of 0.03% tacrolimus ointment (Protopic® in pediatric patients with mild, moderate and severe atopic dermatitis. METHODS: Open, non-comparative, multicentric study carried out in Brazil. 174 patients (ages from two to 10 with mild to severe atopic dermatitis were included. Patients were instructed to apply Protopic® twice a day for six weeks. Primary efficacy criterion was clinical improvement > 90% assessed by the physician (Clinical Response Global Evaluation Scale. Other efficacy criteria included reduction of the Eczema Area Severity Index (EASI, decrease of the affected body surface area (%BSA and evaluation of the itching by the patients or their guardians (visual analogical scale. Safety was evaluated by

  18. Content Determination of Evodiamine and Rutaecarpine in Child Diarrhea Gel Ointment by HPLC%高效液相色谱法测定小儿腹泻凝胶膏中吴茱萸碱及吴茱萸次碱含量

    Institute of Scientific and Technical Information of China (English)

    秦海军; 张毅; 马玲; 陈师农; 任燕茹

    2014-01-01

    Objective To establish a high performance liquid chromatography ( HPLC ) method for determining the evodiamine and rutae-carpine contents in Child Diarrhea Gel Ointment. Methods 80% ethanol was added in Child Diarrhea Gel Ointment and the evodi-amine and rutaecarpine contents were extracted by the ultrasonic method. The HPLC method was adopted with the Cosmosil 5 C18-MS-Ⅱcolumn ( 250 mm × 4. 6 mm, 5μm ) and acetonitrile-water ( 51:49 ) as the mobile phase;the flow rate was 1. 0 mL/min, the the detection wavelength was 225 nm; the injection volume was 10 μL. Results Evodiamine within the range of 0. 089-0. 89 μg had a good linear relationship with the peak area, rutaecarpine within the range of 0. 077-0. 768μg had a good linear relationship with peak area;the average recovery rates of evodiamine and rutaecarpine were 97. 80%, RSD=0. 88% and 99. 87%, RSD=1. 27% respectively. Conclusion The method is simple, accurate, reproducible, which can be used in the content determination of euodiamine and rutae-carpine in Child Diarrhea Gel Ointment.%目的:建立测定小儿腹泻凝胶膏中吴茱萸碱及吴茱萸次碱含量的高效液相色谱( HPLC )法。方法小儿腹泻凝胶膏中加入80%乙醇超声提取吴茱萸碱及吴茱萸次碱,采用HPLC法,色谱柱为Cosmosil 5 C18-MS-Ⅱ柱(250 mm ×4.6 mm,5μm ),乙腈-水(51:49)为流动相,流速为1.0 mL/min,检测波长为225 nm,进样量为10μL。结果吴茱萸碱和吴茱萸次碱进样量分别在0.089~0.89μg和0.077~0.768μg范围内与峰面积呈良好线性关系,吴茱萸碱和吴茱萸次碱的平均回收率为97.80%和99.87%,RSD为0.88%和1.27%。结论该方法简单、准确、重现性好,可用于小儿腹泻凝胶膏中吴茱萸碱及吴茱萸次碱的含量测定。

  19. 湿润烧伤膏联合创疡贴治疗失禁相关性皮炎的疗效分析%Curative Effect Analysis of MEBO Ointment Combined with MEBO Wound & Ulcer Dressing in the Treatment of Incontinence-associated Dermatitis

    Institute of Scientific and Technical Information of China (English)

    何海燕; 康秀华; 陈斌

    2015-01-01

    Objective To investigate the clinical curative effect of MEBO Ointment combined with MEBO Wound&Ulcer Dressing in the treatment of Incontinence-associated Dermatitis. Methods Divide the 34 cases treated from Octo-ber, 2013 to August, 2014 with incontinence-associated dermatitis into two groups randomly; apply MEBO Ointment com-bined with MEBO Wound & Ulcer Dressing in the experiment group (n=17) while apply the radix arnebiaeseulithospermi oil for skin care in the control group (n=17) and observe the curative effects and healing time of dermatitis wounds in the two groups. Results 14 cases healed and 3 cases became better and no case was ineffective in the experiment group while in the control group 7 cases healed and 5 cases became better and 5 cases was ineffective. There was significant difference statistically as comparing the both groups (P<0.05). In the experiment group, the average healing time of mild degree dermatitis was 3.7 d ± 1.4 d and the moderate dermatitis was 5.9 d ± 1.5 d and the severe dermatitis was 7.2 d ± 0.9 d while in the control group, the average healing time of mild degree dermatitis was 5.9 d ± 1.2 d and the moderate dermatitis was 8.2 d ± 1.3 d and the severe dermatitis was 11.3 d ± 0.7 d, and there is significant difference statistically as comparing the both groups (P<0.05). Conclusion The clinical curative effect and healing time of MEBO Ointment combined with MEBO Wound & Ulcer Dressing in the treatment of incontinence-associated dermatitis are superior to that of the radix arnebiaeseulithospermi oil treatment, deserving to be popularized.%目的 探讨湿润烧伤膏联合创疡贴治疗失禁相关性皮炎的临床疗效.方法 将2013年10月至2014年8月收治的34例失禁相关性皮炎患者随机分为两组,试验组(17例)采用湿润烧伤膏联合创疡贴治疗,对照组(17例)采用紫草油护理皮肤,观察两组患者皮炎创面的愈合效果及愈合时间.结果 试验组治愈14例、好转3

  20. HPLC-ELSD法同时测定新氢化可的松乳膏中硫酸新霉素和氢化可的松的含量%Determination of neomycin sulfate and hydrocortisone in hydrocortisone acetate ointment by HPLC-ELSD

    Institute of Scientific and Technical Information of China (English)

    徐兴亚; 李倚云

    2011-01-01

    目的 建立HPLC-蒸发光散射检测器(ELSD)法,同时测定新氢化可的松乳膏中硫酸新霉素和氢化可的松的含量.方法 色谱条件:C18色谱柱(150 mm×4.6 mm,5 μm);流动相:乙腈-0.1 mol/L三氟乙酸溶液(梯度洗脱);漂移管温度:110 ℃;载气流速:2.6 L/min.用硫酸新霉素和氢化可的松对照品分别测定新氢化可的松乳膏中硫酸新霉素和氢化可的松的含量.结果 硫酸新霉素进样量在0.7~4.3 μg范围内(r=0.999 7),氢化可的松进样量在1.0~2.9 μg范围内(r=0.999 9).结论 该方法快速、简便、重现性好,灵敏度高.%Objective To determine the content of neomycin sulfate and hydrocortisone in hydrocortisone acetate ointment by HPLC-ELSD.Methods C 18 ( 150 mm × 4.6 mm,5 μm)column was used, mobile phase:acetonitrile0.1 mol/L trifluoroacetic acid(gradient elution) ,the temperature of drift tube was set at 110 ℃ ,and flow rate of gas was 2.6 L/min.The contents of neomycin sulfate and hydrocortisone in hydrocortisone acetate ointment were determined.Results The calibration curve of neomycin was linear in the range of 0.7 ~ 4.3 μg ( r = 0.999 7 ).The calibration curve of hydrocortisone was linear in the range of 1.0 ~ 2.9 μg ( r = 0.999 9 ).Conclusion The method is rapid,sensitive, accurate and convenient.

  1. 玉红生肌膏配合共鸣火花治疗糖尿病足溃疡临床研究%Clinical research on treating diabetic foot ulcers by Yuhong promoting granulation ointment plus resonance spark treatment instrument

    Institute of Scientific and Technical Information of China (English)

    罗丽华; 苏朝康; 陈祖彦; 李康土; 梁凤娴

    2013-01-01

    Objective: To observe the clinical effect of the Yuhong promoting granulation ointment plus resonance spark treatment instrument. Methods: Take the examples about 102 patients who suffuring from diabetic foot ulcers that are divided into two groups, the treated group was given the Yu Hong promoting ointment (made by our hospital, the main components are angelica sinensis, angelica dahurica, liquorice, radix lithospermi, benne oil, resina draconis, mercurous chloride and insect wax) plus resonance spark treatment instrument; the control group was given the normal saline, insulinum and gentamicin applied by wet gauze. Both take the similar basic cure;the diet balance is using insulinum or oral antidiabetic medicine to control blood sugar under 7.0mmol/L with empty stomach and under 11.0mmoL/L after meal. When there are not any obvious differences, they would be used to treat for 14 days respectively and compared with each other’s treat effect. Results: Using the method really makes more advantages than the other on pain, promoting granulation, curative effect to improve the patients. Conclusion: This cure strengthens the wound healing and treatment effect. And also lays the foundations of creation and accumulating experience combining integrative medicine.%目的:观察玉红生肌膏配合共鸣火花治疗糖尿病足溃疡的临床疗效。方法:通过选取糖尿病足溃疡患者102例,将其随机分成两组,治疗组采用玉红生肌膏(为本院自行研制中药制剂,主要成分为当归、白芷、甘草、紫草、麻油、血蝎、轻粉、白蜡),配合共鸣火花治疗;对照组采用生理盐水+胰岛素+庆大霉素纱布湿敷治疗。两组基础治疗相同,饮食控制,均用胰岛素或口服降糖药控制空腹血糖在7.0mmol/L以下,餐后血糖在11.0mmol/L以下,在血糖指标上无显著差异,分别治疗14d,进行疗效比较。结果:玉红生肌膏配合共鸣火花治疗糖尿病足溃疡

  2. 新型敷料配合湿润烧伤膏在慢性伤口护理中的应用研究%Application and effect evaluation of moist exposed burn ointment combined with new type dressing in chronic wound care

    Institute of Scientific and Technical Information of China (English)

    叶小平; 陈捷清; 黎燕红; 陈晓莹; 蓝凤群; 梁伟平

    2014-01-01

    目的 探讨湿润烧伤膏与新型敷料联合应用促进慢性伤口康复的方法及效果.方法 按随机分组抽签法将60例慢性伤口患者随机分对照组和实验组各30例,对照组换药用生理盐水清洗,让伤口自然愈合、变干,每天换药1次等常规治疗及护理,实验组在常规治疗护理的基础上采用湿润烧伤膏与新型敷料联合应用,措施包括:正确评估伤口,根据伤口愈合不同阶段选择新型敷料及应用湿润烧伤膏,加强基础护理,增加营养,提高免疫力,落实严密的慢性伤口护理监控措施.结果 实验组有效率为93.3%,对照组为70%,实验组明显高于对照组,两组比较差异统计学意义(P<0.05);经治疗2、3、5w后伤口愈合例数实验组明显多于对照组,两组比较差异统计学意义(P<0.05).结论 湿润烧伤膏与新型敷料联合应用于慢性伤口的治疗及护理,可有效地缩短伤口的愈合时间,提高治疗效果.%Objective To discuss application and effect evaluation of moist exposed burn ointment combined with new type dressing in chronic wound care.Methods According to the random draw method 60 cases of chronic wound were randomly divided into control group and experimental group with 30 cases in each group,the control group was given conventional treatment and care such as medicinal saline wash,letting the wound heal,dry and daily dressing,the experimental group based on conventional treatment used moist exposed burn ointment combined with new type dressing,with measures as follows:correcting assessment of the wound,the wound healing in different stages of selection model and application of MEBO dressing,strengthening basic nursing,increasing nutrition,improving immunity,implementing strict control measures for chronic wound care.Results The curative effect of experimental group was significantly higher than that of the control group,the experimental group was 93.3%,while control group 70%,P < 0.05; two

  3. Simultaneous Determination of Neomycin Sulfate and Hydrochloric Dyclonine in Compound Twain Oint-ments by HPLC-DAD-ELSD%HPLC-DAD-ELSD法同时测定复方吐温软膏中硫酸新霉素与盐酸达克罗宁的含量

    Institute of Scientific and Technical Information of China (English)

    段松冷; 曾蔚欣; 孙路路

    2015-01-01

    目的::建立同时测定复方吐温软膏中硫酸新霉素与盐酸达克罗宁含量的HPLC-DAD-ELSD法。方法:采用 Agilent ZOR BAXSB-C18色谱柱(250 mm ×4.6 mm,5μm),以含0.1 mol·L-1三氟乙酸的水溶液、乙腈为流动相,梯度洗脱,流速为1.0 ml·min-1,DAD的检测波长为282 nm,ELSD的漂移管温度为50℃,雾化温度为60℃,载气流速为1.6 L·min-1,柱温为35℃。结果:硫酸新霉素检测浓度的线性范围为141.540~323.520μg·ml-1(r=0.9996),平均回收率为98.87%,RSD=0.95%(n=9);盐酸达克罗宁检测浓的线性范围为28.000~64.000μg·ml-1(r=0.9996),平均回收率为99.57%,RSD=1.10%(n=9)。结论:该方法结果准确、灵敏度高、重复性好,在同一色谱条件下实现了复方吐温软膏中全部有效成分的含量测定,为其质量控制提供了依据。%Objective:To establish an HPLC-DAD-ELSD method for the simultaneous determination of neomycin sulfate and hy-drochloric dyclonine in compound Twaln ointments. Methods:The assay was performed on an Agilent ZOR BAXSB-C18 column(250 mm × 4. 6 mm, 5μm) with acetonitrile-water as the mobile phase with gradient elution at a flow rate of 1. 0 ml·min-1 . The detection wavelength of DAD was 282 nm. The evaporator temperature of ELSD was set at 50℃ and the nebulizer temperature was set at 60℃with the gas flow rate of 1. 6 L·min-1 . The column temperature was kept at 35℃. Results:The linear range of neomycin sulfate was 141. 54-323. 52 μg·mL-1(r=0. 999 6) with the average recovery of 98. 87%(RSD=0. 95%, n=9). The linear range of hydro-chloric dyclonine was 28. 00-64. 00 μg·mL-1(r=0. 999 6) with the average recovery of 99. 57%(RSD=1. 10%, n=9). Conclu-sion:The method is accurate, sensitive and reproducible, and under the same chromatographic conditions, the determination of all the active ingredients in compound Twaln ointments is achieved, which provides basis for the quality control.

  4. Effect and Molecule Psychophysical Mechanism Analysis of Tacrolimus Ointment in Treating Male Patients with Pruritus Ani%外用他克莫司治疗男性肛门瘙痒症疗效及其神经源机制分析

    Institute of Scientific and Technical Information of China (English)

    谢志强; 兰宇贞

    2012-01-01

    Objective To investigate the effect and mechanism of tacrolimus ointment 0.1% in treating adult male patients with pruritus ani. Methods The severity of pruritus (SP) and a basic syntax and molecular substrate (molecular psychophysics) of nociception and pruriception established by temperature-sensitive transient receptor potential (TKP) channels were used to evaluate the severity of pruritus and skin sensory phenomenon. Results The SP score were found to be reduced significantly in 41 patients with pruritus ani after using topical tacrolimus ointment 0.1%. Among them, 34 (82.9%)patients showed positive capsaicin-like response(i.e. burning with consequent rapid amelioration of pruritus or burning sensation). Seven (17.1%) patients showed negative capsaicin-like response. Conclusion Topical tacrolimus may rapidly inhibits or alleviates itch of patients with pruritus ani. The therapeutic effect of topical tacrolimus is relevant to the mechanism that activate or sensitize transient receptor potential vanilloid receptor 1 (TRPV 1) and desensitizes TRPV1 in the skin sensory afferents.%目的 探讨他克莫司软膏对肛门瘙痒症的疗效及其机制.方法 采用瘙痒程度评分及参照由温度敏感的瞬时受体电位通道建立的痛痒觉基本规则和分子底物(即分子精神物理学)方法评估外用0.1%他克莫司软膏治疗前后的肛门瘙痒症患者瘙痒程度及皮肤感觉的变化.结果 外用0.1%他克莫司软膏可终止或显著降低41例男性肛门瘙痒症患者瘙痒程度评分(P<0.05).在41例患者中,34例(82.9%)患者外用0.1%他克莫司软膏后,应用部位产生辣椒素样效应(即灼热感后随之瘙痒和/或烧灼感迅速改善),7例(17.1%)患者缺乏辣椒素样反应.结论 外用他克莫司软膏可终止或降低肛门瘙痒症患者瘙痒,其治疗机制与调节皮肤感觉神经上的瞬时受体电位香草类受体1 (TRPVI)功能有关.

  5. 卡泊三醇联合丙酸氯倍他索软膏治疗寻常性银屑病的疗效观察%Evaluation of the efficacy of calcipotriol ointment plus clobetasol propionate cream for the treatment of psoriasis vulgaris

    Institute of Scientific and Technical Information of China (English)

    杨桂兰; 康晓东; 杨玉华; 王佳媚; 宁舒鹏; 白景睿; 何春峰

    2013-01-01

    Objective To evaluate the efficacy and safety of calcipotriol ointment plus clobetasol propionate cream for the treatment of psoriasis vulgaris.Methods A randomized,open-label and selfcontrolled trial was performed.Totally,197 patients with chronic plaque-type psoriasis were enrolled in this study.Psoriatic lesions in every patients were classified into the right and left parts along the median line of trunk,which were then assigned into the treatment group treated with topical 0.05% calcipotriol ointment twice daily and 0.02% clobetasol propionate cream once daily,and the control group treated with compound clobetasol propionate cream (containing 0.05% clobetasol propionate and 0.025% tretinoin) twice daily,by using a random number table.All the patients were treated for 4 weeks.Symptom score reducing index (SSRI)was calculated at the baseline and every week during the treatment for all the patients,and at 3 months after the end of the treatment for those who were relieved at the end of the treatment.Results Totally,173 patients completed the trial.SSRI was significantly higher in the treatment group than in the control group on day 14 and 21 after the beginning of therapy (0.76 ± 0.17 vs.0.47 ± 0.14,0.90 ± 0.21 vs.0.59 ± 0.19,respectively,both P < 0.05).Additionally,the treatment group showed an increased cure rate (75.72% vs.45.67%,82.66% vs.54.91%,respectively,both P < 0.05) and total response rate (93.06% vs.75.15%,98.85% vs.77.45% respectively,both P < 0.05) on day 14 and 21 compared with the control group.Conclusion Topical application of 0.05% calcipotriol ointment combined with 0.02% clobetasol propionate cream is indeed effective for the treatment of psoriasis vulgaris with mild adverse effect.%目的探讨卡泊三醇软膏联合丙酸氯倍他索软膏外用治疗寻常性银屑病的疗效及不良反应.方法采用随机、开放、平行自身对照试验.197例斑块状银屑病患者皮损沿躯干中

  6. 倍氯米松软膏与维A酸乳膏治疗皮肤丘疹型淀粉样变的临床疗效比较%Efficacy comparison of clobetasol propionate ointment and vitamin A acid cream in the treatment of skin papule type amyloidosis

    Institute of Scientific and Technical Information of China (English)

    宋艳霞; 王云鹏; 高月兰

    2014-01-01

    目的 比较倍氯米松软膏与维A酸乳膏治疗皮肤丘疹型淀粉样变的临床疗效.方法 将皮肤丘疹型淀粉样变100例患者按随机数字表法分为观察组和对照组,每组各50例,对照组采用维A酸乳膏治疗,观察组上采用倍氯米松软膏治疗,治疗4周后,比较两组患者皮损面积、浸润情况、皮肤颜色、皮肤瘙痒评分,以及痊愈率和有效率.结果 (1)两组患者治疗后,症状好转,症状评分较治疗前逐渐减低,观察组于第1周、第2周、第3周、第4周评分分别为(9.35±1.88)分、(6.54 ±2.16)分、(4.08±1.32)分、(2.04±0.95)分,明显优于对照组的(10.86±2.08)分、(7.98 ±2.57)分、(6.25±1.44)分、(4.56±1.18)分,比较差异具有统计学意义(t =6.22、6.71、7.30、7.41,均P<0.05);(2)两组患者治疗4周后,观察组有效率和治愈率分别为94%和34%明显高于对照组的70%和22%,两组比较差异具有统计学意义(x2=9.040、8.391,均P<0.05).结论 倍氯米松软膏在治疗皮肤丘疹型淀粉样变方面较维A酸乳膏症状改善明显,临床效果确切,值得积极推广应用.%Objective To compare clinical efficacy of clobetasol propionate ointment and vitamin A acid cream in the treatment of skin papule type amyloidosis.Methods 100 cases of skin papule type amyloidosis were randomly divided into the observation group and control group,each had 50 patients.The control group was treated with Vitamin A acid cream while the observation group used clobetasol propionate ointment for treatment.Skin lesion area,infiltration,skin color,skin itching score as well as the cure rate and efficiency were compared after 4 weeks of treatment.Results The two groups' symptoms was improved,symptom scores was decreased gradually after treatment than before,the observation group's symptom scores at 1,2,3,4 weeks were (9.35 ± 1.88),(6.54 ±2.16),(4.08 ±1.32),(2.04 ± 0.95) points which was significant better than (10.86 ± 2.08),(7.98 ± 2

  7. 通痹外敷膏联合关节腔冲洗治疗膝骨性关节炎合并积液的临床研究%Clinical study on the treatment of osteoarthritis of the knee with Tongbi topical ointment combined with articular cavity effusion flushing

    Institute of Scientific and Technical Information of China (English)

    唐瑭; 陈德森; 李莉; 朱克刚

    2014-01-01

    Objective To observe the curative effect of traditional Chinese medicine on the treatment of osteoarthritis of the knee with Tongbi topical ointment combined with joint cavity effusion flushing.Methods 366 patients of osteoarthritis of knee joint with effusion were collected from May 2009 to March 2013 in Hubei University of Medicine Affiliated Taihe Hospital,and randomly recruited into a control group and a treatment group by random number table method,with 188 patients in each group.The control group was treated with the joint cavity drainage and oral taking glucosamine hydrochloride capsules,the treatment group was treated with external application of Tongbi ointment based on the control group.Leukocyte osteoarthritis-1 beta (IL-1β) and hyaluronic acid (HA) were measured before and after the treatment.VAS and WOMAC osteoarthritis index were used to evaluate the effect.Results Compared with indexes before the treatment,IL-1β[(39.29±7.52) pg/ml,(28.33 ± 5.42) pg/ml] decreased significantly,HA content [(1.41 ± 0.23) μg/L,(3.34± 0.48) μg/L] increased significantly,VAS score [before treatment and 1-4weeks were (7.21±0.35),(5.47±0.34),(5.04±0.32),(4.03±0.24),(2.23±0.15)] decreased and the WOMAC index[(56.17±7.31),(46.32±6.34),(37.17± 5.31),(29.04±3.58),(15.21 ±2.37)] improved significantly in the treatment group after 4 weeks of treatment.There was a significant difference between the treatment and the control group showed (P<0.05).Combined with the total effective rate of 98.9% (181/183) in treatment group,the control group of 87.4% (160/183) showed a significant difference (P<0.01).Conclusion External application of Tongbi ointment combined with joint cavity flushing was effective in the treatment of osteoarthritis of the knee with effusion.%目的 观察中药通痹外敷膏联合关节腔冲洗术治疗膝骨性关节炎合并关节积液的疗效.方法 收集2009年5月至2013年3月湖北医药学院附属太和医院针灸科膝关

  8. 高压氧与牙周局部注射盐酸米诺环素软膏治疗慢性牙周炎疗效观察%Observation on the clinical efficacies for chronic periodontitis with hyperbaric oxygen and mi-nocycline hydrochloride ointment injection in the periodontal region

    Institute of Scientific and Technical Information of China (English)

    刘智飞; 张湘阳

    2016-01-01

    Objective:To investigate the clinical efficacies of treating chronic periodontitis with hyperbaric oxygen and minocycline hydrochloride ointment injection into the periodontal region,and observe the effect of the agent on inflammatory cytokines TNF-αand C-Reactive protein(CRP).Methods:One hundred patients with chronic periodontitis treated in our hospital were included from March 2014 to November 2015,and randomized into the observational group and control group( n=50 for each) .The sick teeth were briefly treated with conventional supragingival scaling or subgingival curettage .Patients in the control group received minocycline hydrochloride ointment injection in the periodontal region ,whereas those in observational group were treated with hyper-baric oxygen on the therapy basis of the control group.After four weeks of treatment,the two groups were observed concerning the clinical effect,periodontal indexes and changes of TNF-αand CRP levels.Results:The effective rate was 94.00%for observational group and 76.00%for the control group ( P<0.05).Plaque index(PLI),probing depth (PD)and sulcus bleeding index (SBI) were different in both groups from pre-and post-treatment(P<0.05), and these indicators were also different between groups( P<0.05) .TNF-αand CRP levels were different in group and between groups before and after treat-ment( P<0.05) .Conclusion:Combined hyperbaric oxygen with minocycline hydrochloride ointment injection into the periodontal region can lead to better clinical effect on the chronic periodontitis through improving periodontal index and reduce the levels of inflammatory cytokines TNF-αand CRP.%目的:探讨高压氧联合牙周局部注射盐酸米诺环素软膏治疗慢性牙周炎的临床效果及其对炎症因子TNF-α、CRP的影响。方法:选取2014年3月~2015年11月在我院就诊的100例慢性牙周炎患者,随机分为观察组和对照组,每组各50例。常规采用龈上洁治术和(或)龈下刮治术进

  9. 多中心完全随机、标准治疗平行对照评价京万红软膏治疗糖尿病足慢性创面的临床研究%A multicenter randomized study on the clinical effect of Jingwanhong ointment (京万红软膏)on chronic wounds of feet of diabetic patients as compared with routine treatment

    Institute of Scientific and Technical Information of China (English)

    姜玉峰; 杨川; 贾黎静; 鞠上; 王雪梅; 高虹; 付小兵; 许樟荣; 陆树良; 韩春茂; 冉兴无; 曹烨民; 温冰; 谢挺; 成志锋

    2015-01-01

    Objective:To evaluate the effect of Jingwanhong ointment(京万红软膏)on healing of chronic wounds of leg of diabetic patients,to compared with routine treatment by multicenter completely randomized,parallel comparison.Methods:A total of 1 1 hospitals participated in this study,and multicenter,randomized,parallel com-parison was used to compared with routine treatment. One hundred and thirty-one patients with diabetic foot ul-cers were randomly divided into Jingwanhong ointment group (67 patients)and compound sulfadiazine zinc cream group (64 cases),and mean wound area was (16.7±6.1)cm2 and (15.9±8.3)cm2 ,respectively. Duration of ul-ceration was (45.7±68.3)days and (52.5±79.6)days,respectively. Patients of the two groups received Jing-wanhong ointment or compound sulfadiazine zinc cream respectively for a duration of 20 weeks.Results:There was no statistically significant difference in patients’age,duration of suffering from diabetes,routine blood tests,liver function,renal function,etc. In 2,5,10,15 weeks,wound healing rates of Jingwanhong group were higher than that of compound sulfadiazine zinc cream group,especially at 5 and 10 weeks (P<0.01). The average duration ofepithelization of wounds was (46.5±15.6)days in the Jingwanhong group and (67.9±17.9)days in the com-pound sulfadiazine zinc cream group,respectively,with statistically significant difference (P<0.05).Conclusions:Both Jingwanhong ointment and compound sulfadiazine zinc cream could promote healing of diabetic foot wound, and the effect of Jingwanhong ointment is superior.%目的::通过多中心完全随机、标准治疗平行对照方法评价京万红软膏治疗糖尿病足慢性创面的疗效。方法:本研究共有11家医院参加,采用多中心完全随机、标准治疗平行对照、前瞻性临床研究设计。131例糖尿病足溃疡患者随机分为京万红软膏组67例和对照组64例,两组创面面积分别为(16.7±6.1)cm2和(15.9±8.3) cm2,

  10. Effects of Fuhuang Shengji Yuchuang(复黄生肌愈创) Ointment on Expressions of Type Ⅰ and Ⅲ Collagens mRNA in Granulation Wound Tissue in Rats with Diabetes%复黄生肌愈创油膏对大鼠糖尿病创面中Ⅰ型和Ⅲ型胶原mRNA表达的动态影响

    Institute of Scientific and Technical Information of China (English)

    王振宜; 肖秀丽; 唐汉钧

    2011-01-01

    Objective To observe the effects of Fuhuang Shengji Yuchuang (FHSJYC)(复黄生肌余愈创)ointment, a compound traditional Chinese herbal medicine, on the expressions of type Ⅰ and Ⅲ collagens mRNA in wound granulation tissue in rats with diabetes.Methods Wistar rats were randomly divided into three groups:wound control group, normal saline (NS) group and FHSJYC group.Diabetes was induced by injection of 1.5%alloxan and oral gavage of 5% glucose, and skin wound was made in rats of the NS group and FHSJYC group.Skin wounds of the rats in the FHSJYC group were treated with FHSJYC ointment gauze dressing, while those in the NS group were treated with NS gauze dressing once daily.The rats were executed in turn on the third day and the eleventh day of the treatment, and the changes of type Ⅰ and Ⅲ collagen mRNA in the wound granulation tissue were observed by fluorescent real time quantitative polymerase chain reaction.Results Compared with the NS group, the wound closure index in the FHSJYC group was increased (P <0.05) After 3-day treatment, the expression of type Ⅰ and Ⅲ collagens mRNA showed no significant differences among the three groups.After 11-day treatment, the expression of type Ⅰ collagen mRNAs in the FHSJYC group was lower than that in the wound control group (P <0.05), similar with those in the NS group.The expression of type Ⅲ collagen mRNA in the FHSJYC group was higher than that in the NS group (P <0.05), similar with that in the wound control group.Conclusion FHSJYC ointment can affect the process of wound healing by promoting and regulating the expressions of type Ⅰ and Ⅲ collagens mRNA.These results show effects in accelerating wound healing and minimizing scar proliferation in uncurable wound.%目的:动态观察复黄生肌愈创油膏对大鼠糖尿病创面新生肉芽组织中Ⅰ型和Ⅲ型胶原mRNA表达的动态影响.方法:36只雄性Wistar大鼠随机分为创面对照组、模型组、复黄

  11. Influence of the formulation type (o/w, w/o/w emulsions and ointment on the topical delivery of paromomycin Influência da forma farmacêutica (emulsão múltipla A/O/A, emulsão O/A e pomada sobre a permeação e retenção cutânea da paromomicina

    Directory of Open Access Journals (Sweden)

    Sérgio Fernandes de Oliveira Gomes

    2004-09-01

    Full Text Available Ointments containing paromomycin (PA have been used for topical treatment of cutaneous leishmaniasis. Although influence of the vehicle on skin permeation is crucial for optimization of formulations containing PA, this aspect has not been investigated experimentally. In this study, we have evaluated the influence of the formulation type [oil-in-water (o/w, water-in-oil-in-water (w/o/w emulsions and ointment] on in vitro release and skin permeation of PA and experiments were carried out on cellulose acetate membrane and skin biopsies from hairless mice, respectively. PA release from o/w emulsion (51.7% ± 0.9 of dose applied was faster than that observed for w/o/w emulsion (3.0% ± 0.5. PA absorption from o/w emulsion (87.1% ± 3.9 through stripped skin was 5 to 6 times higher than that observed for w/o/w multiple emulsion (14.7% ± 0.5 and ointment (16.6% ± 0.1. PA permeation through intact (normal skin was negligible for all tested formulations. Skin uptake from o/w emulsion (0.9% ± 0.1 was greater than that observed for w/o/w multiple emulsion (0.3% ± 0.1 and ointment (0.1% ± 0.1. These results suggest that a hydrophilic vehicle (o/w emulsion could be an interesting alternative to improve topical delivery of PA.Pomadas contendo paromomicina (PA são utilizadas no tratamento tópico da leishmaniose cutânea. Embora a influência do veículo seja crucial para otimização de formulações contendo PA, este aspecto não tem sido investigado experimentalmente. Neste estudo, nós avaliamos a influência do tipo de formulação [emulsões óleo-em-água (o/a, múltipla água-em-óleo-em-água (a/o/a e pomadas] sobre a liberação e permeação cutânea in vitro da PA e os experimentos foram conduzidos sobre membranas de acetato de celulose e biópsias de pele de camundongos glabros, respectivamente. A liberação de PA a partir da emulsão o/a (51,7% da dose aplicada foi mais rápida do que aquela observada a partir da emulsão múltipla a

  12. 21 CFR 524.390a - Chloramphenicol ophthalmic ointment.

    Science.gov (United States)

    2010-04-01

    ... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS... conjunctivitis, attempts should be made to determine through susceptibility testing, which antibiotics will be... animals producing meat, eggs, or milk. The length of time that residues persist in milk or tissues has...

  13. Studies on cleaning validation for a cream and ointment ...

    African Journals Online (AJOL)

    Methods: The worst case product of the line chosen was a cream containing three practically insoluble ingredients: .... products. The validation process involved three consecutive batches of the worst-case product. The facility ..... Approach.

  14. Internal sphincterotomy versus topical nitroglycerin ointment for chronic anal fissure

    Directory of Open Access Journals (Sweden)

    Muhammad I. Aslam

    2014-01-01

    Conclusion: This quasi-experimental study demonstrates that open partial lateral internal sphincterotomy is superior to topical 0.2% nitroglycerin application in the treatment of chronic anal fissure, with good symptomatic relief, high rate of healing, fewer side effects, and a very low rate of early continence disturbances.

  15. [Pregnancy and lactation: antibiotics. mouthwashes and pastes or ointments.

    Science.gov (United States)

    Fatori Popovic, Sandra; Lübbers, Heinz-Theo; von Mandach, Ursula

    2016-01-01

    The aim of this paper is to show aspects of dental treatment in pregnancy. The reader should gain security in the election of the proper drugs for antibiotic therapy and rinsing solutions. Antibiotics as penicillins are the first choice in case of dental infections in pregnancy. In allergic patients, macrolides may be an alternative. Wound and mouth rinsing solutions containing chlorhexidine should be preferred in pregnancy. Ledermix(®) in endodontic treatment should be avoided in the pregnant woman. Solcoseryl(®) can be used for wound healing. Elective dental procedures should be postponed after delivery and after lactation period.

  16. Wound Healing Activity of Elaeis guineensis Leaf Extract Ointment

    Directory of Open Access Journals (Sweden)

    Sreenivasan Sasidharan

    2011-12-01

    Full Text Available Elaeis guineensis of the Arecaceae family is widely used in the traditional medicine of societies in West Africa for treating various ailments. To validate the ethnotherapeutic claims of the plant in skin diseases, wound healing activity was studied. The results showed that E. guineensis leaf extract had potent wound healing capacity as evident from the better wound closure (P < 0.05, improved tissue regeneration at the wound site, and supporting histopathological parameters pertaining to wound healing. Matrix metalloproteinases expression correlated well with the results thus confirming efficacy of E. guineensis in the treatment of the wound. E. guineensis accelerated wound healing in rats, thus supporting its traditional use. The result of this study suggested that, used efficiently, oil palm leaf extract is a renewable resource with wound healing properties.

  17. Wound healing activity of Elaeis guineensis leaf extract ointment.

    Science.gov (United States)

    Sasidharan, Sreenivasan; Logeswaran, Selvarasoo; Latha, Lachimanan Yoga

    2012-01-01

    Elaeis guineensis of the Arecaceae family is widely used in the traditional medicine of societies in West Africa for treating various ailments. To validate the ethnotherapeutic claims of the plant in skin diseases, wound healing activity was studied. The results showed that E. guineensis leaf extract had potent wound healing capacity as evident from the better wound closure (P < 0.05), improved tissue regeneration at the wound site, and supporting histopathological parameters pertaining to wound healing. Matrix metalloproteinases expression correlated well with the results thus confirming efficacy of E. guineensis in the treatment of the wound. E. guineensis accelerated wound healing in rats, thus supporting its traditional use. The result of this study suggested that, used efficiently, oil palm leaf extract is a renewable resource with wound healing properties.

  18. 烫伤消疤软膏对猪深Ⅱ度烧伤创面愈合影响的实验研究%Experimental study on the effects of Tang Shang Xiao Ba burn ointment on deep partial thickness burn wound healing in pigs

    Institute of Scientific and Technical Information of China (English)

    黄康; 陈玉林; 刘旺; 俞为荣; 郇京宁; 夏照帆

    2001-01-01

    Objective To observe the effects of TangShangXiaoBa burn ointment (TSXBBO) on deep partial thickness burn wound healing in pigs,and to investigate the possible mechanism of this traditional Chinese medicine in accelerating burn wound healing.Method A model of deep partial thickness burn wound in pigs was used.All wounds were divided into two groups,one side TSXBBO,and another control After topical application of TSXBBO to burn wound in pigs.the biopsies of burn wound were taken for measuring hydroxyproline contents,percentage of G0/G1- phase and percentage of s- phase in full skin cells of burn wound,water contents,rates of burn wound healing and pathological changes ingroup of TSXBBO and control at 1,3,5,7,10 and 14 day postburn.Result The hydroxyproline contents,the percentage of s- phase in full skin cells of burn wound and the rates of burn wound healing were all higher,and the water contents and percentage of G0/G1- phase were less in group TSXBBO than the control group.Conclusion It is suggested that topical application of TSXBBO to deep partial thickness burn wound in pigs may stimulate collagen synthesis,accelarate keratinocyte proliferation,reduce dropsy of burn wound and enhance wound healing.%目的观察烫伤消疤软膏对猪深Ⅱ度烧伤创面愈合影响。方法采用猪深Ⅱ度烧伤模型,创面外用烫伤消疤软膏,通过伤后不同时相点创面取材,检测烧伤创面羟脯氨酸( OHP)含量、创面细胞 DNA含量和细胞周期变化、创面含水量、创面愈合率及组织病理形态学变化。结果创面外用烫伤消疤软膏后创面羟脯氨酸含量、创面细胞 S期细胞百分比、创面愈合率均高于烧伤对照组,而创面含水量、创面细胞 G0/G1期细胞百分比均低于烧伤对照组。结论烧伤创面外用烫伤消疤软膏可增强胶原合成,促进上皮细胞增殖,减轻烧伤创面早期水肿,加速烧伤创面愈合。

  19. Comparative study on the clinical effect of minocycline hydrochloride ointment and lodine glycerin as adju-vant therapy for pericoronitis with parulis%米诺环素软膏与碘甘油辅助治疗第三磨牙冠周炎伴牙龈脓肿的效果比较

    Institute of Scientific and Technical Information of China (English)

    葛光华; 李晋芳; 江小平; 吴琼

    2016-01-01

    目的:比较盐酸米诺环素软膏与碘甘油辅助治疗第三磨牙冠周炎伴牙龈脓肿的临床效果。方法164例患第三磨牙冠周炎伴牙龈脓肿的青年大学生患者,随机分为2组,每组82例,2组均行牙龈脓肿切开排脓、冠周冲洗上药、口服替硝唑、头孢拉啶和复方硼砂含漱液含漱等综合治疗,试验组冠周上质量分数2%的盐酸米诺环素软膏,每3天1次;对照组冠周上质量分数1%的碘甘油,每天1次。治疗3d后复诊,对比2组的疗效。结果试验组总有效率为93.9%,对照组为78.0%,差异有统计学意义(χ2=8.546,P=0.003)。2组均未发生药物不良反应。结论盐酸米诺环素软膏辅助治疗第三磨牙冠周炎伴牙龈脓肿可收到良好的临床效果。%Objective To compare the clinical effects of minocycline hydrochloride ointment (Periocline) and lo⁃dine glycerin as adjuvant therapy for pericoronitis with parulis. Methods 164 college students suffering from pericoro⁃nitis with parulis were divided into 2 groups randomly: observation group (82 cases) and control group (82 cases). All cases were treated with incision and drainage of the parulis, and then pericoronal rinsing. What's more, tinidazole and cefradine plus compound borax gargle mouthwash were given to them. 2% Periocline was filled into the periodontal pocket for the observation group (q3d) while 1% lodine glycerin was filled into the periodontal pocket for the control group (qd). Clinical effects of the two groups were observed and compared 3 days later. Results The effective rate of observation group (93.9%) was higher than that of control group (78.0%) with statistically significance (χ2=8.546, P=0.003). No drug adverse reaction occured. Conclusion It shows good effects when Periocline is applied as an adju⁃vant therapy for pericoronitis with parulis.

  20. 湿润烧伤膏与磺胺嘧啶银霜在烧伤创面修复中的疗效比较%Efficacy comparison of Moisture Burn Ointment and Sulfadiazine-Ag Cream in burn wound repair

    Institute of Scientific and Technical Information of China (English)

    杨伯明

    2011-01-01

    目的:比较湿润烧伤膏(MEBO)暴露再生疗法与磺胺嘧啶银霜(SD-Ag霜)抗炎疗法在修复烧伤创面中的疗效.方法:选择2008年10月~2010年12月我院不同原因、不同分度、于伤后0.5~12.0 h入院的60例烧伤患者,随机分为两组,观察组30例患者烧伤创面采用MEBO暴露再生疗法,对照组30例患者采用磺胺嘧啶银霜抗炎治疗.观察两组不同深度烧伤创面的愈合时间、感染发生率、手术植皮例数及瘢痕发生率.结果:两组患者第3、6、9、12天创面愈合率差异均有统计学意义(均P0.05).结论:在治疗烧伤创面修复中,美宝湿润烧伤膏暴露再生疗法优于磺胺嘧啶银霜抗炎疗法,不仅能明显缩短创面愈合时间,提高创面愈合率,还能降低瘢痕发生率,减少手术植皮患者比例.%Objective: To compare the treatment efficacy of Moisture Burn Ointment (MEBO) exposure regeneration therapy and Sulfadiazine-Ag (SD-Ag) Cream anti-inflammatory therapy in bum wound repair. Methods: 60 cases of bum patients who entered our hospital from October 2008 to December 2010 with different reasons, different types and in hospital 0.5-12.0 hours after injuries were assigned randomly to two groups. 30 patients in the observation group were given MEBO exposure regeneration treatment and the 30 patients in the control group were given SD-Ag Cream anti-inflammatory treatment. The healing time, incidence of infection, cases of surgery graft and incidence of scar formation of wound of different depth were compared between the two groups. Results: There were significant differences between the two groups in wound recovery rate of day 3, 6, 9 and 12 (P<0.05); the wound repair time of the observation group was(16.2±5.47) d and (20.50±5.24) d in the control group, the difference between the two groups was significant (P<0.01); the incidence of scar formation was 30.0% in the observation group and 56.7% in the control group, the difference between

  1. Clinical Efficacy of Mupirocin Ointment,Recombinant Bovine Basic Fibroblast Growth Factor and Active Silver Ion So-lution for Transplantation of Free Skin Graft on Infectious Wounds%莫匹罗星和重组牛碱性成纤维细胞生长因子联合活性银离子治疗感染创面游离植皮的临床疗效研究

    Institute of Scientific and Technical Information of China (English)

    汪洋; 张小红; 冉辉; 谭加; 陶宏军

    2014-01-01

    目的:探讨莫匹罗星、重组牛碱性成纤维细胞生长因子( rb-bFGF)联合活性银离子治疗感染性创面游离植皮的疗效,为以后的治疗提供依据。方法选取2010年6月—2013年6月重庆三峡中心医院收治的行断层皮片封闭感染性创面手术的患者168例,采用随机数字表法分为观察组84例和对照组84例。观察组术中将莫匹罗星和rb-bFGF制成的混合液涂抹于受区,皮片移植后外用浸湿活性银离子的无菌绷带予以固定;对照组术中用油纱覆盖游离皮片。观察术后第4、8、12天创面情况,评估皮片存活率、创面愈合率、创面愈合时间及细菌清除率。皮片存活率、创面愈合率及细菌清除率比较采用χ2检验,创面愈合时间比较采用t检验。结果术后第4天观察组皮片存活率为(97.9±1.2)%,高于对照组的(85.8±5.7)%(t=20.62,P=0.002)。术后第8天观察组创面愈合率为7.1%(6/84),对照组为1.2%(1/84),差异无统计学意义(χ2=3.71,P =0.054);术后第12天观察组创面愈合率为98.8%(83/84),高于对照组的72.6%(61/84)(χ2=23.39,P <0.001)。观察组创面平均愈合时间为(11.4±1.4)d,短于对照组的(13.3±3.0)d(t =-5.92,P =0.007)。术后第4天观察组细菌清除率为72.6%(61/84),高于对照组的46.4%(39/84)(χ2=11.89,P=0.001);术后第8天观察组细菌清除率为90.5%(76/84),高于对照组的77.4%(65/84)(χ2=5.31,P=0.020);术后第12天观察组细菌清除率为100.0%(84/84),高于对照组的94.0%(79/84)(χ2=5.12,P=0.023)。结论莫匹罗星、rb-bFGF联合活性银离子能提高感染性创面游离植皮的成活率、加速创面愈合、增强局部抗感染能力。%Objective To study the efficacy of mupirocin ointment,recombinant bovine basic fibroblast growth factor ( rb-bFGF)combined with active silver ions solution on free skin

  2. Drug: D05237 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D05237 Drug Hydrophilic ointment (JP16); Ointment, hydrophilic (USP); Hydrophilic o...intment (TN) Pharmaceutic aid [ointment base, oil-in-water emulsion] Therapeutic category: 7122 Therapeutic category of dr...712 Ointment bases 7122 Emulsion bases D05237 Hydrophilic ointment (JP16); Ointment, hydrophilic (USP) CAS: 8022-61-5 PubChem: 17398254 ...

  3. Percutaneous penetration of methyl nicotinate from ointments using the laser Doppler technique: bioequivalence and enhancer effects.

    Science.gov (United States)

    Remane, Yvonne; Leopold, Claudia S; Maibach, Howard I

    2006-12-01

    Laser Doppler flowmetry (LDF) may be used to quantify erythema response as a result of an increased cutaneous microcirculation induced by methyl nicotinate (MN). Bioequivalence of a test and a standard preparation (vehicles: light mineral oil and medium chain triglycerides, respectively) was confirmed according to the pilot study of the FDA Guidance for Industry "Topical dermatologic corticosteroids: In Vivo bioequivalence" applying the staggered application and synchronized removal method for one defined concentration. Furthermore, the influence of penetration enhancers (5% w/w Dimethylsulfoxide (DMSO) and 10% w/w diethylene glycol monoethyl ether) on MN penetration was investigated. It was shown that DMSO and diethylene glycol monoethyl ether altered cutaneous microcirculation and thus MN penetration in comparison to the standard formulation. However, true penetration enhancement could only be proved with diethylene glycol monoethyl ether resulting from an improved drug solubility in the skin which was confirmed by attenuated total reflectance fourier transform infrared spectroscopy (ATR-FTIR). Increased MN penetration by DMSO was only caused by thermodynamic effects, i.e. a decreased drug solubility in the vehicle.

  4. Subdermal penetration of topically applied clobetasol propionate in ointment base through intact human skin

    DEFF Research Database (Denmark)

    Petersen, Lars Jelstrup; Sindrup, J H; Kristensen, J K

    1992-01-01

    . The 133Xenon wash-out method was used for the measurement of subcutaneous blood flow. Resting blood flow and the local blood flow regulatory mechanisms, autoregulation of blood flow and the veno-arteriolar reflex, were assessed prior to treatment and were measured following 24, 48 and 72 h of treatment...

  5. 21 CFR 524.1484c - Neomycin sulfate, isoflupredone acetate, tetracaine hydrochloride ointment.

    Science.gov (United States)

    2010-04-01

    ...) Conditions of use. (1) It is used in treating such conditions as acute otitis externa in dogs and to a lesser degree, chronic otitis externa in dogs. It also is effective in treating anal gland infections and moist..., following ear trimming and castrating operations. (2) In treatment of otitis externa and other...

  6. Development of a new formulation combining calcipotriol and betamethasone dipropionate in an ointment vehicle

    DEFF Research Database (Denmark)

    Simonsen, Lene; Høy, Gert; Didriksen, Erik

    2004-01-01

    Calcipotriol and betamethasone dipropionate are widely used effective treatments for psoriasis. Combined therapy is known to be superior to monotherapy, but current formulations do not permit simultaneous application as the drug substances will degrade when mixed. The purpose of the study...... was to develop a formulation which combines calcipotriol and betamethasone dipropionate in a single vehicle hereby achieving optimal delivery of both substances into the skin. As the two substances are incompatible in aqueous and alcoholic medias, different non-aqueous formulations were prepared. Skin permeation...... ether (PSE) had a marked effect. A 5% PSE formulation resulted in a permeation rate comparable to the marketed products. Thus, by using PSE as solvent, it was possible to combine calcipotriol and betamethasone dipropionate in a single formulation while optimal skin permeability was attained. Recently...

  7. Industrialization of crustaceans for obtaining chitosan in effect ointment wound healing

    OpenAIRE

    García Zapata, Teonila; Universidad Nacional Mayor de San Marcos; Roca Ortega, Johana Melissa; Universidad Nacional Mayor de San Marcos

    2014-01-01

    Between 20 to 30, the weight of the kind of crust,Crustaceans is used human food, no human is the rest consisting of viceras and exoskeleton, especially the carapaces of hairy crab, crab raped her ceo, jaivas, lobster, shrimp that are found in greater numbers along the coasts of thePeruvian coast,which are regarded as environmental pollutants (waste ) These compounds are commercially valuable untapped, which can be used to obtain two biopolymers specialized high valueadded established worldwi...

  8. Evaluation of mupirocin ointment in control of central venous catheter related infections: a randomized clinical trial

    Directory of Open Access Journals (Sweden)

    Rezaei J

    2009-09-01

    Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 st1":*{behavior:url(#ieooui } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Central venous catheter (CVC related infections are important complications of cathter application. This study assessed the usefulness of mupirocin in prevention and control of these infections."n"nMethods: In this randomized clinical trial, consecutive surgical patients requiring central venous catheter (for more than 2 days in Amir-Alam Hospital from 2006-2008 were enrolled. Patients were divided in two groups; in "case group" patients received topical mupirocin 2% every 48 hours at the time of insertion of catheter and dressing change and for "control group" mupirocin was not used. All of the patients received chlorhexidine and enoxoparin as complementary treatments. Two groups were comparable in regard of age, sex and risk factors."n"nResults: One hundred eighteen patients enrolled in the study (57 in case and 61 in control group completed the study. 84 catheters in case group and 88 catheters in control group were inserted. The catheters in 90% of patients were inserted in jugular vein. At the end of study 29(16.8% patients (16 in control versus 13 in case group had catheter colonization (p=NS. Catheter related bloodstream infection was observed in 16(9.3% patients (6 in case versus 10 in control group (p=NS.Catheter related local infection was seen in 2(1.1% patients of control versus none of mupirocin group. (p=NS."n"nConclusions: Mupirocin was not effective to control and prevention of bacterial colonization and catheter related infection  

  9. Arnica Ointment 10% Does Not Improve Upper Blepharoplasty Outcome : A Randomized, Placebo-Controlled Trial

    NARCIS (Netherlands)

    van Exsel, Denise C. E.; Pool, Shariselle M. W.; van Uchelen, Jeroen H.; Edens, Mireille A.; van der Lei, Berend; Melenhorst, Wynand B. W. H.

    2016-01-01

    Background: It has been suggested that arnica can reduce postoperative edema and ecchymosis associated with cosmetic surgical procedures and improve outcome. Despite a high incidence of arnica use among upper blepharoplasty patients, evidence to support its treatment effect is lacking. The authors p

  10. Arnica Ointment 10% Does Not Improve Upper Blepharoplasty Outcome : A Randomized, Placebo-Controlled Trial

    NARCIS (Netherlands)

    van Exsel, Denise C E; Pool, Shariselle M W; van Uchelen, Jeroen H; Edens, Mireille A; van der Lei, Berend; Melenhorst, Wynand B W H

    2016-01-01

    BACKGROUND: It has been suggested that arnica can reduce postoperative edema and ecchymosis associated with cosmetic surgical procedures and improve outcome. Despite a high incidence of arnica use among upper blepharoplasty patients, evidence to support its treatment effect is lacking. The authors p

  11. Clinical Control Observation of MEBO Ointment and Shengji Yuhong Ointment in the Treatment of Pressure Ulcers%MEBO与生肌玉红膏治疗压迫性溃疡的临床对照观察

    Institute of Scientific and Technical Information of China (English)

    杜林海; 张俊会; 张学军; 邵建阁

    2012-01-01

    目的 对比观察外用湿润烧伤膏(MEBO)与生肌玉红膏治疗压迫性溃疡的临床效果.方法 将56例压迫性溃疡患者的84处创面随机分为治疗组和对照组,治疗组采用MEBO治疗,对照组采用生肌玉红膏治疗,分别统计两组创面愈合情况,并进行比较.结果 治疗组的创面改善情况、肉芽生长情况和愈合时间均优于对照组.结论 MBEO可以有效地清除坏死组织、促进肉芽组织生长,加速压迫性溃疡创面愈合,临床疗效显著.

  12. Time of erythema onset after application of methyl nicotinate ointments as response parameter: influence of penetration kinetics and enhancing agents.

    Science.gov (United States)

    Remane, Y; Leopold, C S

    2006-01-01

    The time of erythema onset may be used as a response parameter for quantification of the cutaneous erythema response induced by methyl nicotinate. The vehicles light mineral oil (LMO; test) and medium chain triglycerides (MCT; standard) were compared with regard to the pharmacodynamic response. Moreover, the influence of penetration enhancers on the time of erythema onset was investigated under zero order penetration kinetics. The enhancers dimethyl sulfoxide, diethylene glycol monoethyl ether and three different glycerides in different concentrations were added to MCT as a standard vehicle. All preparations were applied to the forearms of volunteers under infinite dose conditions at different thermodynamic drug activity levels (0.2-3.2% of the saturation level) and different drug concentrations (0.051-0.816%), respectively. Different penetration kinetics do not influence data of erythema onset, as these data are comparable to those obtained under finite dose conditions (first order penetration kinetics). With regard to the penetration enhancers, a significantly enhanced penetration of methyl nicotinate could be observed only for diethylene glycol monoethyl ether and dimethyl sulfoxide. However, no significant difference between light mineral oil and MCT could be found with regard to penetration enhancement. The time of erythema onset is an easy and efficient parameter for quantification of the pharmacodynamic response caused by nicotinates.

  13. 11 Acnes Caused by Tacrolimus Ointment%他克莫司软膏致痤疮11例

    Institute of Scientific and Technical Information of China (English)

    李志国; 陈宾; 袁秀丽

    2011-01-01

    目的 探讨他克莫司软膏导致痤疮的不良反应特点.方法 对2008年8月~2009年6月间我科应用他克莫司软膏导致痤疮的临床资料进行整理,分析.结果 他克莫司软膏致痤疮主要发生在青年,男性多于女性,多在用药2~3周后发生.表现为粉刺,炎性小丘疹,脓疱.结论 对于他克莫司软膏致痤疮的规律及特点,应引起临床医师足够的重视,加强预防,以减少不良反应的发生.

  14. The use of nasal mupirocin ointment to prevent Staphylococcus aureus bacteraemias in haemodialysis patients: an analysis of cost- effectiveness

    NARCIS (Netherlands)

    J.R. Boelaert; M. A. Geernaert; C.A. Godard (Claudine); H.W. van Landuyt; Y.A. de Baere

    1991-01-01

    textabstractNasal carriage of Staphylococcus aureus is a risk factor for the development of infections caused by S. aureus in haemodialysis patients. This study compared the incidence of bacteraemia caused by S. aureus during 6 months of use of nasal 2% calcium mupirocin ('Nasal Bactroban') 3-times

  15. [Antibiotic ointments and methicillin-resistant Staphylococcus aureus with a reservoir in a healthcare worker in a tertiary hospital].

    Science.gov (United States)

    Molina-Cabrillana, Jesús; Del Rosario-Quintana, Cristóbal; Tosco-Núñez, Tomas; Dorta-Hung, Elena; Quori, Anna; Martín-Sánchez, Antonio M

    2013-10-01

    Methicillin-resistant Staphylococcus aureus (MRSA) has become an important hospital-acquired pathogen, with transfer of the organism from a carrier or infected patient to uninfected patients by the hands or clothing of staff as the main mode of transmission. Investigation of a cluster of new cases of MRSA resistant to mupirocin and fusidic acid, using epidemiological and microbiological resources. From September 2010 to February 2012, sixteen patients had at least one culture positive for MRSA resistant to mupirocin and fusidic acid. Some not apparently related cases and outbreaks appeared. By analysing cultures taken from patients and staff using pulsed-field gel electrophoresis, it was demonstrated that most likely this situation was started by an auxiliary nurse who was a carrier of the MRSA. Healthcare worker decontamination using oral antibiotic therapy was unsuccessful. Eventually, the situation was controlled by placing the carrier in a different job, with no further cases to date (September, 2012). This report illustrates the risk of nosocomial transmission linked to care delivered by healthcare workers. Copyright © 2012 Elsevier España, S.L. All rights reserved.

  16. "A Fly in the Ointment": African American Male Preservice Teachers' Experiences with Stereotype Threat in Teacher Education

    Science.gov (United States)

    Scott, Sonya V.; Rodriguez, Louie F.

    2015-01-01

    This study draws from a larger phenomenological study on African American academic persistence and career aspirations in education. This article highlights three African American males' experiences with concentrated forms of stereotype threat in teacher education. Their voices revealed dimensions of how power and privilege operate in teacher…

  17. A case of lichen striatus associated with alopecia areata universalis in an adult woman: successful treatment with tacrolimus ointment

    OpenAIRE

    ERPOLAT, Seval; HALTAŞ, Hacer

    2013-01-01

    AbstractA 40-year-old woman was admitted to our clinic with the complaints of itchy lesions appearing on the right leg for five months. The patient had also suffered hair loss of her scalp, eyebrows, legs and arms for one year. The patient was diagnosed as lichen striatus with this histopathologic and clinical findings. The coexistence of these clinical presentations in the same patient may support the role of autoimunity in the pathogenesis. In this case report, successful treatment of liche...

  18. 镇痛膏(巴布贴)毒理实验研究%Toxicologic Experimental Study on Analgesic Ointment

    Institute of Scientific and Technical Information of China (English)

    党庆先; 钟雪梅; 万礼仪; 党庆德; 熊军

    2004-01-01

    目的研制纯中药制剂-镇痛膏(巴布贴)用于穴位敷贴治疗腹部术后痛证及一切急、慢性疾患疼痛.方法制定镇痛膏制备工艺,考察该制剂的毒理实验.结果本品制备工艺合理、稳定、可行.毒理实验研究该制剂未显示皮肤刺激性反应;无明显皮肤致敏反应;无毒副作用.结论本品可用于临床.

  19. Topical effectiveness of kiwifruit versus fibrinolysin ointment on removal of necrotic tissue of full-thickness burns in male rats.

    Science.gov (United States)

    Kooshiar, Hadi; Abbaspour, Hadi; Motamed Al Shariati, Seyed Mohamad; Rakhshandeh, Hasan; Khajavi Rad, Abolfazl; Esmaily, Habibollah; Vahdati Nia, Behnam

    2012-01-01

    Formation of necrotic tissues is a major issue affecting treatment of full-thickness burns. This study was designed to compare topical effectiveness of applying kiwifruit versus fibrinolysin on removal of necrotic tissue of burns. Ten adult male Wistar rats were randomly assigned to three groups. For group 1, the right-side wounds were treated with kiwifruit and the other side with fibrinolysin. For group 2, the wounds on the right side were treated with kiwifruit or fibrinolysin, and the left sides were kept as control group 2. All wounds in group 3 were considered as control group 1. The control wounds were left to heal naturally. In each group and for each wound, the time of debridement were noted. The results indicated that for the wounds where kiwifruit was applied, the average time for removal of dead tissue was 5.7 days, which is significantly shorter than the average 18.5 days it took for treatment with fibrinolysin (p = 0.02). However, there were no significant differences between control wounds 1 and 2. Findings of the present study can open new horizons and provide a new treatment modality for patients with deep burns.

  20. "A Fly in the Ointment": African American Male Preservice Teachers' Experiences with Stereotype Threat in Teacher Education

    Science.gov (United States)

    Scott, Sonya V.; Rodriguez, Louie F.

    2015-01-01

    This study draws from a larger phenomenological study on African American academic persistence and career aspirations in education. This article highlights three African American males' experiences with concentrated forms of stereotype threat in teacher education. Their voices revealed dimensions of how power and privilege operate in teacher…

  1. 21 CFR 524.154 - Bacitracin or bacitracin zinc-neomycin sulfate-polymyxin B sulfate ophthalmic ointment.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Bacitracin or bacitracin zinc-neomycin sulfate... TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.154 Bacitracin or bacitracin zinc-neomycin sulfate-polymyxin B...: (1) To 000009; each gram contains 500 units of bacitracin, 3.5 milligrams of neomycin, and...

  2. [The study of quality characteristics of the hydrogel ointments and films based on copolymers divinyl esters of diethylene glycol].

    Science.gov (United States)

    Bakirova, R E; Tazhbaeva, E M; Muravleva, L E; Fazylov, S D; Akhmetova, S B

    2014-12-01

    The possibility of using a hydrogel based on divinyl ether co- and terpolymer of diethylene glycol as the backbone polymer for incorporating water-soluble medicinal substances was examined. The character of the influence of emulsifiers, plasticizers, high-boiling liquids and bioactive substances is defined within the changes of physical-chemical properties of obtained hydrogels. The obtained polyelectrolyte hydrogels by their homogeneity, dehydration and rheological characteristics may be of concern in function of matrices to create external prolonged-action dosage forms.

  3. Nasal Carriage of Staphylococcus Aureus and Cross-Contamination in a Surgical Intensive Care Unit: Efficacy of Mupirocin Ointment

    NARCIS (Netherlands)

    D. Talon; C. Rouget; V. Cailleaux; P. Bailly; M. Thouverez; F. Barale; Y. Michel-Briand

    1995-01-01

    textabstractA six month prospective study was carried out in a surgical intensive care unit (SICU) of a university hospital to assess the incidence and routes of exogenous colonization by Staphylococcus aureus. A total of 157 patients were included in the study. One thousand one hundred and eleven s

  4. Comparative evaluation of topical Sodium fusidate cream in common pyodermas with topical gentamicin ointment and systemic antibiotics

    Directory of Open Access Journals (Sweden)

    Roy AK

    1996-01-01

    Full Text Available ABSTRACT: One hundred cases of common pyodermas consisting of four groups, namely impetigo, furunculosis and chronic folliculitis were taken. Each group containing twenty five cases were divided again into three subgroups. From each group, 15 were treated with 2 percent Sodium fusidate cream, 5 were with 0.1 percent Gentamycin sulphate cream and the rest 5 with systemic Erythromycin stearate. In the group of Impetigo, Bockhart′s Impetigo and Furunculosis, topical Sodium fusidate cream showed excellent result, better than Gentamycin topical and equal to that of systemic Erythromycin stearate.

  5. Drug: D05287 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D05287 Mixture, Drug Simple ointment (JP16); Simple ointment (TN) Yellow beewax [DR... in Japan [BR:br08301] 7 Agents not mainly for therapeutic purpose 71 Dispensing medicines 712 Ointment bases 7121 Oil bases D05287 Simple ointment (JP16) PubChem: 17398268 ...

  6. A STUDY ON ROLE OF VARIOUS TYPES OF TOPICAL OINTMENT AND ITS OUTCOME AMONG BURN PATIENTS : AN INTERESTING FOLLOW UP STUDY

    Directory of Open Access Journals (Sweden)

    Sunita

    2015-08-01

    Full Text Available Burn injury causes major bulk of the surgical emergencies. Burn infection makes the burn wound complicated causes considerable mortality and morbidity. Timely and effective use of antimicrobial and topical dressings revolutionizes burn care by decreasing invasive wound infection. The administration of broad - spectrum antibiotics on routine basis is likely to en courage. The emergence of resistant organism therefore, timely and judicial use of antibiotics is essential for better result. MATERIAL AND METHOD S: The present study was carried out in 160 burns and scald admitted in surgical wards in Department of General Surgery, SGMH and S.S. Medical College, Rewa ( M. P. during period of one year. The cases are fully recorded and thoroughly studied with the aim of establishing the incidence, mode of burn and causes of burn, source of burn, clothing at timed incidence, time and place of incidence and detail clinical assessment. On admission resuscitation started with intravenous fluid, calculated according to the Parkland formula and prophylactic antibiotic giv en in all the patients after sampling for culture and sensitivity. Symptomatic and supportive treatment added as per need. RESULTS : Out of 160 patients, majority of the patient belong to 21 – 40 year 48.1%. Majority of patient ( 34.4% had total body surfac e burn area burnt between 21 - 40% and 12.5% patient had burnt area 61 - 80%. Maximum ( 50.0% complain of irritation was reported by the patients to whom Silver sulphadizine was applied while least ( 10% by the patients to whom nadoxin e was applied. CONCLUSION : The incident of invasive infection and overall mortality was significantly reduced after the introduction into clinical practice of topical burn wound anti - microbial agent, our study shows that the most effective topical antimicrobial agent in burn patie nt is Nadoxine.

  7. 红霉素眼膏效价的浊度法测定%Determination of Erythromycin Eye Ointment by Turbidimetry

    Institute of Scientific and Technical Information of China (English)

    魏立平; 张润婕

    2007-01-01

    建立了浊度法测定红霉素眼膏效价.采用标准曲线法,以金黄色葡萄球菌为实验菌,加菌量0.3%(v/v),37℃培养3~4h,于530nm在线测定.红霉素浓度在0.4~1μg/ml的范围内,吸光度D与其浓度对数1gc线性关系良好(r=0.9998).方法平均回收率为98.9%,RSD为2.0%.

  8. Study on the safety of Ketoconazole Clobetasol Ointment on affected area%酮康他索软膏局部用药的安全性研究

    Institute of Scientific and Technical Information of China (English)

    陈百泉; 孙慧玲

    2005-01-01

    目的:评价酮康他索软膏临床局部用药的安全性;方法:分别采用家兔及豚鼠进行药物的眼刺激、完整及破损皮肤等刺激试验及皮肤过敏试验;结果:酮康他索软膏均无刺激性及过敏性反应;结论:试验结果提示酮康他索软膏作为皮肤用药是安全的.

  9. 米诺环素软膏治疗牙周炎的效果%Effect of minocycline ointment on the patients underwent periodontitis

    Institute of Scientific and Technical Information of China (English)

    郑艺; 汤洪毅; 陈京华

    2014-01-01

    目的:观察米诺环素软膏治疗牙周炎的效果。方法:90例牙周炎患者随机分为两组:米诺环素组和碘甘油组。米诺环素组患者使用米诺环素软膏,碘甘油组患者使用碘甘油和替硝唑。记录两组患者的治疗效果。结果:米诺环素组患者的治疗效果比碘甘油组的好( P<0.05)。结论:米诺环素软膏治疗牙周炎患者的效果良好。%Objective To observe the effect of Minocycline ointnent on the patients underwent periodontitis. Method Ninety patients underwent periodontitis were randonly divided into two groups:ninocycline group and iodine glycerin group. In the ninocycline group,the patients were adninistrated with ninocycline ointnen. In the iodine glycerin group,the patients were adninistrated with iodine glycerin and tinidazole. The therapeutic effect in both groups were recorded. Results The therapeutic effect in ninocycline group was better than that in iodine glycerin group(P<0. 05). Conclusion Minocycline ointnent is effective for the patients underwent periodontitis.

  10. Toxic experimental study of ivermectin ointment in the skin%伊维菌素乳膏皮肤毒性实验研究

    Institute of Scientific and Technical Information of China (English)

    申成华; 郑善子; 崔春权; 玄英花; 李太一

    2002-01-01

    [目的]研究伊维菌素乳膏对动物皮肤的毒性作用.[方法]利用健康SD大鼠进行皮肤急性毒性试验,用健康白兔进行皮肤刺激性试验,用健康豚鼠进行皮肤过敏试验.[结果]伊维菌素乳膏对大鼠完整皮肤及破损皮肤均无急性毒性反应,对白兔完整皮肤和破损皮肤无刺激性,对豚鼠完整皮肤无致敏作用.[结论]伊维菌素乳膏用于预防和治疗与人体蠕形螨有关的酒糟鼻、痤疮及毛囊炎时是较安全的.

  11. 颈痛灵软膏镇痛作用的药理研究%Pharmacologieal Research of Gutongling Ointment on Analgesic Effect

    Institute of Scientific and Technical Information of China (English)

    李铁成; 苏南

    2007-01-01

    目的:观察颈痛灵软膏(ITLO)的镇痛作用.方法:通过小鼠扭体法致痛、热板法致痛、大鼠辐射热照射法致痛试验,对ITLO的镇痛作用进行药理研究.结果:TTLO对小鼠扭体法及热板法致痛,大鼠辐射热照射法致痛均具有明显抑制作用.结论:JTLO对多种疼痛模型均具有明显的抑制作用.

  12. 癌痛消外敷治疗癌性疼痛50例%Fifty Patients with Cancer Pain Treated by External Application with Aitong Xiao Ointment

    Institute of Scientific and Technical Information of China (English)

    宋国平

    2007-01-01

    @@ 癌性疼痛是中晚期癌症病人的常见症状之一,也是最难控制的症状之一.我科自2000年以来,采用自拟癌痛消外敷治疗癌性疼痛50例,疗效较好,现报道如下. 一般资料 所有病人均为我科2000~2006年住院病人,其中肝癌12例,肺癌16例,胰腺癌4例,胃癌8例,食管癌10例;年龄最大76岁,最小52岁;发病时间最长3年,最短4个月.

  13. WR279,396, a third generation aminoglycoside ointment for the treatment of Leishmania major cutaneous leishmaniasis: a phase 2, randomized, double blind, placebo controlled study.

    Directory of Open Access Journals (Sweden)

    Afif Ben Salah

    Full Text Available BACKGROUND: Cutaneous leishmaniasis (cl is a disfiguring disease that confronts clinicians with a quandary: leave patients untreated or engage in a complex or toxic treatment. Topical treatment of CL offers a practical and safe option. Accordingly, the treatment of CL with WR279,396, a formulation of paromomycin and gentamicin in a hydrophilic base, was investigated in a phase 2 clinical study in Tunisia and France. METHODS: A phase 2, randomized, double blind, vehicle-controlled study was conducted to assess the safety and efficacy of topical WR279,396 when applied twice a day for 20 days as treatment for parasitologically confirmed CL. The study protocol established the primary efficacy end point as complete clinical response (CCR defined as 50% or greater reduction in the ulceration size of an index lesion by day 50 (D50 followed by complete re-epithelialization by D100, and no relapse through D180. RESULTS: Ninety-two subjects were randomized. Leishmania major was identified in 66 of 68 isolates typed (97%. In the intent-to-treat population, 47 of 50 WR279,396 treated participants (94% met the definition of CCR, compared with 30 of 42 vehicle-placebo participants (71% [p = 0.0045]. Erythema occurred in 30% and 24% of participants receiving WR279,396 and placebo, respectively [p = 0.64]. There was no clinical or laboratory evidence of systemic toxicity. CONCLUSION: Application of WR279,396 for 20 days was found to be safe and effective in treating L. major CL, and offers great potential as a new, simple, easily applicable, and inexpensive topical therapy for this neglected disease. TRIAL REGISTRATION: ClinicalTrials.gov NCT00703924.

  14. 40 cases of chloasma treated by acupuncture and the ointment recipe%针刺配合膏方治疗黄褐斑40例

    Institute of Scientific and Technical Information of China (English)

    赵玉广; 罗双喜; 石艳芬; 张炳生; 王媛

    2008-01-01

    黄褐斑是对称性发生于面部或额、眉间、鼻、口周淡褐色至深褐色或淡黑色的色素沉着斑,色斑形状不规则,但边界清楚,又称“蝴蝶斑”。2005-06—2007-06,笔者采用针刺配合膏方治疗黄褐斑40例,疗效满意,总结报道如下。1临床资料80例均为本院针灸科门诊女性患者,按就诊先后顺序随机分为两组。治疗组40例,年龄23~52岁;病程2个月~8年;肝郁气滞型18例,脾虚湿蕴型9例,肾水不足型8例,肾阳不足型5例。对照组40例,年龄25~49岁;病程3个月~10年;肝郁气滞型17例,脾虚湿蕴型11例,肾水不足型6例,肾阳不足型6例。两组评分结果,见表1。按照1998年中国中西医结合学会皮肤性病专业委员会色素病学组制定的评分标准,即:0为无皮损;1为皮损分布于面部双侧,面积4 cm2,深褐色。两组一般资料对比,差别无统计学意义(P>0.05),具有可比性。表1两组评分结果组别例数1分2分3分治疗组40 3 18 19对照组40 2 20 182治疗方法治疗组给予针刺加膏方内服。①针刺疗法。取穴足三里、曲池、血海、三阴交、关元...

  15. One case of transient mental disorder caused by atropine eye ointment%阿托品眼膏引起短暂性精神错乱1例

    Institute of Scientific and Technical Information of China (English)

    黄刚哲; 金世兰

    2006-01-01

    @@ 1临床资料 患者女,12岁,因视远物不清,在我院眼科就诊,为调节充分麻痹后检查眼的屈光状态和屈光度的目的,用1%阿托品眼膏(3次/d).第1天用阿托品眼膏后出现口干、头晕、视物模糊.第2天继续用阿托品眼膏后,患者神志不清,言语零乱,兴奋躁动.但无呕吐,无四肢抽搐.入院查体:体温37℃、脉搏102次/min、呼吸20次/min、血压110/70 mmHg.神志不清,言语零乱,兴奋躁动,有错觉及幻觉,查体不能合作.颜面潮红,双侧瞳孔扩大,呼吸运动规则,双肺未闻及干、湿罗音,心率102次/min,节律整齐,心脏各瓣膜区未闻及病理性杂音.临床诊断为阿托品中毒,用息斯的明皮下注射及安定肌注后,患者安静入睡.第2天清晨睡醒后,患者无口干,无头晕,神情语明,自主体位,双侧瞳孔等大同圆,无瞳孔扩大,心率76次/min,节律整齐.

  16. 痛风膏治疗痛风的临床观察%Clinical Observe on Gout Ointment in Treating Gout

    Institute of Scientific and Technical Information of China (English)

    丁庆余; 宋恩峰; 任开明; 胡家才; 程虹

    2009-01-01

    目的:研究痛风膏对痛风的治疗效果.方法:将100例痛风患者随机分为2组.对照组:痛风定胶囊2粒/次,3次/d.治疗组:在对照组基础上,用中药痛风膏外敷,2次/d.2周为1疗程,共治疗2个疗程.观察止痛时间.血β2-M、血红蛋白、24h尿蛋白、血尿酸、肾功能等指标的变化.结果::①治疗组血β2-M显著下降(P<0.01),对照组无变化(P>0.05),治疗组血红蛋白较治疗前明显改善(P<0.01),24h尿蛋白治疗组治疗后有显著改善(P<0.01),对照组前后比较差异无统计学意义(P>0.05),两组均能改善尿液pH值(P<0.01).组间比较差异无统计学意义(P>0.05).②两组均能降低血尿酸、BUN、Scr(P<0.01),但两组比较差异有统计学意义(P<0.05).③治疗组与对照组总有效率分别为90%、72%,组间比较差异有统计学意义(P<0.05).④两组用药后关节红肿热痛时间:治疗组为3±1.2d,对照组为7±2.6d,治疗组明显短于对照组(P<0.01)结论:痛风膏治疗痛风有较好疗效,其止痛迅速,改善肾功能,降低血尿酸,减少蛋白尿.

  17. Wet-wrap treatment using dilutions of tacrolimus ointment and fluticasone propionate cream in human APOC1 (+/+) mice with atopic dermatitis

    NARCIS (Netherlands)

    Oranje, A.P.; Verbeek, R.; Verzaal, P.; Haspels, I.; Prens, E.; Nagelkerken, L.

    2009-01-01

    Background: Wet-wrap treatment (WWT) with diluted topical steroids is widely used in atopic dermatitis (AD). Mice with transgenic overexpression of human apolipoprotein C1 (APOC1) in the liver and the skin are not only characterized by hyperlipidaemia and raised IgE levels, but also by pruritic

  18. Effect analysis of 89 cases of psoriasis vulgaris treated with Qing Peng ointment combined with three alcohol ointments%青鹏软膏联合卡泊三醇软膏治疗寻常型(进行期)银屑病89例效果分析

    Institute of Scientific and Technical Information of China (English)

    李晓琴

    2016-01-01

    目的:探讨青鹏软膏联合卡泊三醇软膏治疗寻常型(进行期)银屑病的效果.方法:选取我院收治的寻常型(进行期)银屑病89例,按照随机数字表法分成观察组和对照组,观察组45例采用青鹏软膏联合卡泊三醇软膏治疗,对照组44例采用糠酸莫米松软膏联合卡泊三醇软膏治疗,观察两组临床疗效和不良反应.结果:两组在治疗后14d临床疗效比较无明显差异(P>0.05);两组均未发生严重不良反应,但在皮肤刺激发生率上比较有明显差异(P<0.05).结论:青鹏软膏联合卡泊三醇软膏治疗寻常型(进行期)银屑病与糠酸莫米松软膏联合卡泊三醇软膏治疗疗效相当,而且无严重不良反应.

  19. Drug: D04662 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available apeutic purpose 71 Dispensing medicines 712 Ointment bases 7122 Emulsion bases D046...ointment base, absorbent] Therapeutic category: 7122 Therapeutic category of drugs in Japan [BR:br08301] 7 Agents not mainly for ther

  20. Dermatological exposure to coal tar and bladder cancer risk: a case-control study

    NARCIS (Netherlands)

    Roelofzen, J.H.; Aben, K.K.H.; Kerkhof, P.C.M. van de; Valk, P.G. van der; Kiemeney, L.A.L.M.

    2015-01-01

    OBJECTIVE: Coal tar ointments are used as treatment of various skin diseases, especially psoriasis and eczema. These ointments contain several carcinogenic polycyclic aromatic hydrocarbons. Metabolites of these polycyclic aromatic hydrocarbons are excreted in the urine and therefore, dermatological

  1. Crisaborole Topical

    Science.gov (United States)

    ... It works by blocking the action of certain natural substances in the body that cause inflammation. ... are treating them with crisaborole ointment. If a caregiver has applied the ointment, they should wash their ...

  2. Bacitracin Ophthalmic

    Science.gov (United States)

    ... hands thoroughly with soap and water. Use a mirror or have someone else apply the ointment. Avoid ... or do not go away: itching, stinging, or burning of the eye Bacitracin eye ointment may cause ...

  3. Erythromycin Ophthalmic

    Science.gov (United States)

    ... hands thoroughly with soap and water. Use a mirror or have someone else apply the ointment. Avoid ... do not go away: redness, itching, stinging, or burning of the eye Erythromycin eye ointment may cause ...

  4. Dermatological exposure to coal tar and bladder cancer risk: a case-control study

    NARCIS (Netherlands)

    Roelofzen, J.H.; Aben, K.K.H.; Kerkhof, P.C.M. van de; Valk, P.G. van der; Kiemeney, L.A.L.M.

    2015-01-01

    OBJECTIVE: Coal tar ointments are used as treatment of various skin diseases, especially psoriasis and eczema. These ointments contain several carcinogenic polycyclic aromatic hydrocarbons. Metabolites of these polycyclic aromatic hydrocarbons are excreted in the urine and therefore, dermatological

  5. 21 CFR 333.110 - First aid antibiotic active ingredients.

    Science.gov (United States)

    2010-04-01

    ... gram, 30 milligrams of chlortetracycline hydrochloride in a suitable ointment base. (d) Neomycin sulfate ointment containing, in each gram, 3.5 milligrams of neomycin in a suitable water soluble or oleaginous ointment base. (e) Neomycin sulfate cream containing, in each gram, 3.5 milligrams of neomycin...

  6. Variation of topical application to skin under good clinical practice (GCP)

    DEFF Research Database (Denmark)

    Vind-Kezunovic, Dina; Serup, Jørgen Vedelskov

    2016-01-01

    clinical practice (GCP) study designed to investigate the local tolerability and safety on healthy skin of captopril 1% ointment versus a placebo ointment. Volunteers were instructed to apply an even layer of test ointment on a 51 cm(2) test area on the arm twice daily over a 3-week period. At weekly...

  7. Uptake of pyrene in a breast-fed child of a mother treated with coal tar.

    NARCIS (Netherlands)

    Scheepers, P.T.J.; Houtum, J.L.M. van; Anzion, R.B.M.; Harder, R.; Bos, R.P.; Valk, P.G.M. van der

    2009-01-01

    A woman was treated for atopic dermatitis with coal tar containing ointments. Coal tar containing ointments contain genotoxic polycyclic aromatic hydrocarbons. Over a period of 50 days the accumulated dose of different coal tar containing ointments treatments corresponded to 993 mg of pyrene and 464

  8. WOUND HEALING ACTIVITY OF UNGUENTUM DOSAGE FORM OF ETHANOLIC EXTRACTS OF Areca catechu L. NUT IN Mus musculus albinus

    Directory of Open Access Journals (Sweden)

    Azizah Vonna

    2015-10-01

    Full Text Available The activity test of ethanol extract of betel nut ointment (Areca catechu L. in wound healing on mice (Mus musculus albinus has been carried out to determine the ability of the ethanol extract of betel nut ointment in wound healing and determine the concentration which was accelerate the wound healing on mice between 2 concentrations. This experimental research method used completely randomized design (CRD using 20 mices divided into 4 treatment groups ; ointment base, povidone iodine ointment, ethanol extract of betel nut ointment (SEEBP 2% and SEEBP 4%. Each treatment groups was tested in the incision which was made along the 15 mm parallel to the spine (Os. Vetebre with the depth until subcutaneous skin layers. The ointment was applied twice a day for about 21 days and observed changes every day for during the period of observation. The results showed that the average length of time of the scab formation, the scab exfoliation, and the wound healing successively are for the ointment base was 6.6; 10.2 and 18.2 days, povidone iodine ointment was 7; 11.2 and 14.8 days, SEEBP 2% was 5.75; 7.75 and 13.25 days, SEEBP 4% was 4.2; 8.8 and 12.8 days. ANOVA and LSD results of scab formation time showed a significant difference between SEEBP 4% with base ointment and povidone iodine ointment (p <0.05. Results of the exfoliation scab showed a significance difference between SEEBP 2% with base ointment and povidone iodine ointment (p <0.05. The duration of wound healing showed that there was significance difference between SEEBP 2%, SEBP 4% and povidone iodine ointment with ointment base  (p<0.05.Thus, betel nut ointment as an effect on healing process. The concentration which can accelerate wound healing in mice is SEEBP 4%.

  9. Pharmacokinetics and Antiinflammatory Effect of a Novel Gel System Containing Ketoprofen Solid Nanoparticles.

    Science.gov (United States)

    Nagai, Noriaki; Iwamae, Aya; Tanimoto, Shion; Yoshioka, Chiaki; Ito, Yoshimasa

    2015-01-01

    We previously reported that dermal application using nanoparticles improves skin penetration. In this study, we prepared novel topical formulations containing ketoprofen (KET) solid nanoparticles (KETnano gel ointment) and investigated the antiinflammatory effect of the KET nanoparticle formulations on rheumatoid arthritis using adjuvant-induced arthritis (AA) rats. The KETnano gel ointment was prepared using a bead mill method and additives including methylcellulose and Carbopol 934; the mean particle size of the KET nanoparticles was 83 nm. In the in vitro skin penetration experiment, the penetration rate (Jc) and penetration coefficient through the skin (Kp) values of the KETnano gel ointment were significantly higher than those of gel ointment containing KET microparticles (KETmicro gel ointment; mean particle size 7.7 µm). On the other hand, in the in vivo percutaneous absorption experiment, the apparent absorption rate constant (ka) and the areas under the KET concentration-time curve values in the skin of rats receiving the KETnano gel ointment were significantly higher than those of rats receiving the KETmicro gel ointment, and the amounts of KET in the skin tissues of rats receiving the KETnano gel ointment were also significantly higher than those of rats receiving the KETmicro gel ointment. In addition, the application of the KETnano gel ointment attenuated the enhancement of paw edema of the hind feet of AA rats more than the application of the KETmicro gel ointment. Our findings suggest that a topical drug delivery system using nanoparticles could lead to expansion in the therapeutic use of KET.

  10. 五种阿昔洛韦软膏释放与透皮性质比较%The comparison of five ointment formulations of acyclovir on release rate and percutaneous rate in vitro

    Institute of Scientific and Technical Information of China (English)

    马晓微; 何飞燕; 梁文权

    1999-01-01

    目的:探讨不同的软膏基质对阿昔洛韦(ACV)透皮性能的影响.方法:设计四种不同基质的处方,测定ACV从处方中的释放与经皮渗透性质,并与商品ACV软膏进行比较.结果:四种软膏基质中ACV的释放速率与透皮速率均大于商品ACV软膏,乳膏基质、Ⅰ号凝胶基质、PEG基质、Ⅱ号凝胶基质中药物的透皮速率分别是商品软膏的2.47,4.98,12.79与17.85倍.结论:由卡巴浦、月桂氮酮、丙二醇、薄荷油及辅助促透剂组成的ACV软膏为较好的处方.

  11. Clinical Observation of "Feng Ointment" and Thermal Therapy for the Treatment of Hyperkeratotic Hand Eczema%疯油膏结合热烘疗法治疗手部角化性湿疹的临床观察

    Institute of Scientific and Technical Information of China (English)

    吴怡峰; 潘陈彬; 傅佩骏; 顾乃芳

    2015-01-01

    目的:观察疯油膏结合热烘疗法治疗手部角化性湿疹的临床疗效.方法:选择符合入组标准的手部角化性湿疹患者,并随机分为治疗组与对照组.治疗组采用疯油膏结合热烘疗法治疗,对照组采用糠酸莫米松乳膏治疗.两组均以4周为1个疗程,连续观察2个疗程的皮损情况,并评价临床疗效及安全性.结果:两组在各疗程的JHS积分与VAS积分均较治疗前显著降低(P<0.01),且治疗组JHS积分在第1、第2疗程均明显低于对照组(P<0.05,P<0.01),VAS积分在第2疗程后也较对照组明显降低(P<0.05);2疗程中,治疗组的有效率分别为85.4%、93.8%,对照组为58.0%、64.0%,治疗组均显著优于对照组(P<0.01).治疗组有2例因出现局部皮肤刺激症状退出观察,其余未出现任何不良反应.结论:疯油膏结合热烘疗法治疗手部角化性湿疹疗效显著,且较少出现不良反应.

  12. Clinical Trial of Chronic Hand Eczema with Topical Tarcrolimus Ointment%他克莫司软膏治疗慢性手部湿疹临床观察

    Institute of Scientific and Technical Information of China (English)

    王秋枫; 张昊; 夏汝山; 杨维玲; 江彬彬

    2009-01-01

    目的:评价外用0.1%他克莫司软膏治疗慢性手部湿疹的临床效果和安全性;方法:给予28例慢性手部湿疹患者外用0.1%他克莫司软膏,2/d,晚间行封包治疗(≥6 h),共4周;于治疗前及治疗后1、2、4周和停药后2周各随访1次,疗效评估使用标准的手部湿疹评分(JHS)和临床严重性分级,并记录不良反应.结果:28例中26例完成临床试验.治疗后2周同治疗前相比JHS明显下降,直到研究结束其分值持续下降,最终12例(46.2%)完全治愈.临床分级也得到明显改善.药物相关性不良反应主要表现为用药部位烧灼感(15.4%)和瘙痒(11.5%),严重程度多为轻到中度,且均为一过性.结论:0.1%他克莫司软膏对治疗慢性手部湿疹具有良好的疗效,安全性较高.

  13. 他克莫司软膏治疗慢性手部湿疹的临床研究%Clinical study of tacrolimus ointment in the treatment of chronic hand eczema

    Institute of Scientific and Technical Information of China (English)

    王秋枫; 李丽; 夏汝山; 江彬彬; 杨维玲

    2010-01-01

    目的 评价0.1%他克莫司软膏治疗成人慢性手部湿疹的疗效和安会性.方法 86例慢性手部湿疹患者按就诊顺序进入试验组和对照组,分别接受0.1%他克莫可软膏(试验组)或丁酸氢化可的松乳膏(对照组)治疗;每日2次,疗程为4周;于治疗前及治疗后每周随访1次,疗效评估使用标准的手部湿疹评分系统(JHS),患者作视觉尺度VAS瘙痒症状测试及皮炎改善程度的自我评估,并记录不良反应.结果 经过4周的治疗后,试验组和对照组的有效率分别为83.7%和46.5%,试验组的有效率高于对照组(P<0.05).治疗后,试验组的JHS明显下降,与患者自我评价符合,同对照组JHS相比,差异有统计学意义.试验组9例局部出现不同程度灼热、瘙痒等不适感,均于2~3 d后消失;对照组3例出现一过性皮肤发红、刺痛,停药后消失.结论 0.1%他克莫司软膏治疗慢性手部湿疹安全且效果良好.

  14. Determination of Hyodeoxycholic Acid in Porcin Gallbladder Powder and Menthol Ointment by RP-HPLC%RP-HPLC测定猪胆粉薄荷脑软膏中猪去氧胆酸的含量

    Institute of Scientific and Technical Information of China (English)

    陈勇; 李文霞; 马临科

    2008-01-01

    目的:建立猪胆粉薄荷脑软膏中猪去氧胆酸的含量测定方法.方法:采用 RP-HPLC法,以Zorbax SB C18为色谱柱,流动相为甲醇-0.1%甲酸溶液(80:20),流速为0.5 mL·min-1,采用蒸发先散射检测器,漂移管温度为90℃,氮气流速为1.6 L·min-1.结果:猪去氧胆酸线性范围为0.706 8-10.602μg,r=0.999 3.猪去氧胆酸的平均回收率为97.61%,RSD为2.4%.结论:本方法定量准确,重复性好,可用于猪胆粉薄荷脑软膏的质量控制.

  15. Feet soaking with Chinese herbs and external use of Alfalfa burn ointment for treating diabetic foot%中药泡足联合紫花烧伤膏外敷治疗糖尿病足

    Institute of Scientific and Technical Information of China (English)

    吴熹

    2010-01-01

    目的 探讨中药泡足联合紫花烧伤膏外敷治疗糖尿病足的疗效.方法 将65例发生糖尿病足患者随机分为观察组(33例)和对照组(32例).观察组用中药(主药为黄柏、黄连、黄岑、丹参、红花等)泡足后外敷紫花烧伤膏,对照组用庆大霉素、山莨菪碱、胰岛素湿敷.结果 观察组糖尿病足治疗效果显著优于对照组(P<0.05).结论 应用中药泡足联合紫花烧伤膏外敷治疗糖尿病足治愈率高,操作简单.

  16. HPLC法测定复方丙酸氯倍他索软膏中丙酸氯倍他索和维A酸的含量%Determination of Clobetasol Propionant and Tretinoin in Compound Clobetasol Propionant Ointment by HPLC

    Institute of Scientific and Technical Information of China (English)

    汪旭; 严铁; 高中华; 熊东旭; 孙钰

    2015-01-01

    目的 建立HPLC法测定复方丙酸氯倍他索软膏中丙酸氯倍他索和维A酸的含量.方法 应用HPLC法,以2种主要成分为指标,采用WondaSil C18(250 mm×4.6 mm,5μm)色谱柱;流动相为甲醇-0.1%磷酸溶液(梯度洗脱,采用不同的检测波长);流速为1.0 ml ·min-1.结果 丙酸氯倍他索和维A酸的线性范围分别为0.06~0.60 μg(r=1)和0.03~0.30 μg(r=1).平均回收率分别为99.67%、100.01%;RSD分别为0.66%、1.26%.结论 本方法结果准确,精密度高,可同时测定丙酸氯倍他索软膏中丙酸氯倍他索和维A酸的含量,可用于此软膏制剂的质量控制.

  17. Efficacy of clobetasol propionate compound ointment for the treatment of psoriasis vulgaris%复方丙酸氯倍他索软膏治疗寻常性银屑病临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    毕志刚; 倪容之; 秦万章; 顾军; 庞传超; 于浩

    2004-01-01

    目的:观察复方丙酸氯倍他索软膏治疗寻常性银屑病的疗效和安全性.方法:将入组的360例寻常性银屑病患者分为治疗组(复方丙酸氯倍他索软膏组120例)、对照1组(0.02%丙酸氯倍他索霜组120例)和对照2组(0.05%全反式维A酸霜组120例),采用多中心、随机双盲、平行对照的方法对寻常性银屑病患者连续用药4周.结果:3组患者的痊愈率分别为48.33%、18.33%和3.48%,有效率分别为92.50%、50.83%和31.30%.组间比较(试验组与对照1组比较,试验组与对照2组比较)显示,痊愈率和有效率差异均有显著性(P<0.01).试验组和对照1组的不良反应发生率较轻微,对照2组不良反应发生率为11.67%,有3例因不良反应较重中途停止治疗.结论:复方丙酸氯倍他索软膏是一种安全有效的治疗寻常性银屑病的外用药,其疗效优于单用丙酸氯倍他索霜或全反式维A酸霜.

  18. 复方丙酸氯倍他索软膏治疗寻常型银屑病%Clinical study of clobetasol propionate compound ointment for treatment of psoriasis vulgaris

    Institute of Scientific and Technical Information of China (English)

    车敦发; 倪容之; 管海宏; 曹扬; 张敏; 邓德权

    2006-01-01

    目的:观察复方丙酸氯倍他索软膏(含0.05% 丙酸氯倍他索和0.025%全反式维甲酸)外用治疗寻常型银屑病的疗效和安全性.方法:采用随机、双盲、平行对照试验.72例寻常型银屑病随机分入治疗组(复方丙酸氯倍他索软膏),对照1组(0.02%丙酸氯倍他索霜)及对照2组(0.025%全反式维甲酸霜).每组每天用药2次,连续治疗4周.试验结束后观察主、客观各项指标的变化,并进行统计学分析.结果:4周后治疗组痊愈率62.50%,有效率95.83%,与对照1组及对照2组均有显著性差异,无不良反应发生.结论:复方丙酸氯倍他索软膏外用治疗寻常型银屑病安全、有效.

  19. The clinical observation of Tretinoin Ointment and Levamisole treatment in verruca planae%维A酸乳膏联合左旋咪唑治疗扁平疣的疗效观察

    Institute of Scientific and Technical Information of China (English)

    张晓彬; 曾庆伟

    2009-01-01

    目的:观察维A酸乳膏联合左旋咪唑治疗扁平疣的疗效.方法:选择信阳职业技术学院附属医院2008年2月~2009年1月收治的83例扁平疣患者,随机分为观察组(43例)和对照组(40例),对照组采用单纯维A酸乳膏治疗,观察组采用维A酸乳膏与左旋咪唑联合治疗.比较分析两组的疗效.结果:观察组总有效率为97.67%,对照组总有效率为85.00%,两组间比较,差异有统计学意义(X2=4.3107,P0.05).结论:维A酸乳膏联合左旋咪唑治疗扁平疣疗效满意,安全可靠,值得推广应用.

  20. Determination of Vitamin B12 in Vitamin B12 Compound Ointment- Ⅰ by HPLC%复方维生素B12软膏Ⅰ号中维生素B12的HPLC测定

    Institute of Scientific and Technical Information of China (English)

    杨谊; 李兵; 史学慧

    2004-01-01

    建立了HPLC法测定复方维生素B12软膏Ⅰ号中维生素B12的含量.采用Hypersll BDS C18柱,流动相为乙腈-0.05mol/L磷酸二氢钾溶液(15:85),检测波长360nm.维生素B12在0.16~0.8μg范围内线性关系良好(r=0.9995),平均回收率为98.4%,RSD为0.9%.

  1. 尿素乳酸软膏治疗寻常型鱼鳞病临床研究%A Clinical Trial of Urea & Lactic Acid Compound Ointment for the Treatment of Ichthyosis Vulgaris

    Institute of Scientific and Technical Information of China (English)

    汪科; 季素珍; 陈喜雪; 朱学骏

    2005-01-01

    目的:评价尿素乳酸软膏治疗寻常型鱼鳞病的有效性和安全性.方法:采用随机双盲、安慰剂对照研究,试验组和对照组均为每日外用药2次,疗程4周.结果:共入组寻常型鱼鳞病患者26例,包括试验组和对照组各13例.治疗4周后,试验组的总有效率为91.6%,而对照组的总有效率为25.0%.两组之间的有效率比较,具有统计学意义.两组均无不良事件发生.结论:尿素乳酸软膏治疗寻常型鱼鳞病具有很高的疗效,且安全性和耐受性良好,使用方便.

  2. Clinical study on treatment of acne vulgaris with compound polymycin B ointment%复方多黏菌素B软膏治疗寻常痤疮临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    吴意平; 杨敏; 吴司南; 常建民; 傅裕

    2012-01-01

    目的 观察复方多黏菌素B软膏治疗寻常痤疮的疗效及安全性.方法 将156例寻常痤疮患者分为两组,试验组外用复方多黏菌素B软膏每日2次,对照组外用5%过氧苯甲酰凝胶每日2次,疗程均为4周.结果 试验组患者经治疗4周后皮损数量明显较治疗前减少,与对照组相比差异有统计学意义(P<0.05);皮损消退显效率两组无明显差异(P>0.05);不良反应发生率试验组低于对照组(P< 0.05).结论 复方多黏菌素B软膏治疗Ⅰ、Ⅱ级寻常痤疮有效,且不良反应少.%Objective To evaluate the effect and safety of compound polymycin B cream in treating acne vulgaris. Methods 156 acne vulgaris patients (Ⅰ,Ⅱ stage) were randomly divided into two groups, the treatment group were topically applied compound polymycin B cream and control group were topically applied 5% benzoylperoxide gel. The course of treatment was 4 weeks. Results The results showed the difference of effective rates between two groups was not statistically significant (P>0.05), the side effects in the compound polymycin B cream treatment group was less than the control group (P<0.05). Conclusion The study indicates that, comparing with 5% benzoylperoxide gel, compound polymycin B cream topical treatment for acne vulgaris I, II stagestage is effective and safer.

  3. Investigation of methods for the determination of anticoagulation activity of Hirudoid Ointment with rabbit plasma%采用兔血浆测定喜疗妥软膏抗凝活性的方法探讨

    Institute of Scientific and Technical Information of China (English)

    荫少民; 潘燕冰; 朱志鹏

    2000-01-01

    目的:拟采用兔血浆代替人血浆(Sigma)对喜疗妥作抗凝活性测定.方法:APTT法.结果:三批样品的兔血浆法效价分别为27011u/100g、26387u/100g、26614u/100g;人血浆法分别为26601u/100g、25984u/100g、25422u/100g.结论:本法与人血浆法试验结果无显著性差异.

  4. The efficacy of hirudoid ointment for chemotherapy-induced phlebitis%喜辽妥软膏防治化疗性静脉炎的效果观察

    Institute of Scientific and Technical Information of China (English)

    谢佐卿; 石金秀; 刘德忠; 姚春花

    2011-01-01

    目的 探索一种操作简单、疗效显著、医护人员及病人乐于接受的预防和治疗化疗性静脉炎的方法.方法 将使用环磷酰胺、5-氟脲嘧啶、表阿霉素化疗的住院病人随机分为实验组与对照组:实验组40例应用喜辽妥软膏在穿刺处周围并沿血管走向涂抹10~15 cm,每天2次.每次化疗后继续涂抹3天;对照组41例则按传统静脉炎处理方法,用50%硫酸镁湿敷,每天2次,每次化疗后继续涂抹3天.结果 两组病人静脉炎发生率分别为22.50%,67.29%(P<0.05).发生的静脉炎分级比较,疼痛缓解时间和炎症消除时间实验组均低于对照组,差异有显著性(P<0.05).结论 喜辽妥软膏局部涂抹能有效减少环磷酰胺、5-氟脲嘧啶、表阿霉素所致的化学性静脉炎的发生,减轻静脉炎发生的程度,保证了化疗的正常进行,值得推广应用.%Objective To explore a simple, effective therapy in the prevention and treatment of chemotherapy-induced phlebitis which medical staff and patients are all willing to use. Methods 81 patients who received chemotherapy with cyclophosphamide, 5-fluorouracil, and pharmorubicin were randomly divided into two groups:study group ( n = 40 ) and control group ( n = 41 ). In the study group, hirudoid was applied around the puncture point and along the direction of the vessel of 10 - 15cm, twice daily for three days after the start of chemotherapy. The control group received traditional therapy for phlebitis - wet dressing with 50% magnesium sulfate, twice daily for three days. Results The incidence of phlebitis was 22.50% in hirudoid group and 67.29% in magnesium sulfate group ( P< 0.05 ). The time of pain-relief and that of inflammation elimination were shorter in the study group than in the control group ( P < 0.05 ). Conclusions Topical hirudoid can effectively reduce the incidence rate of cyclophosphamide-, 5-fluorouracil-, and pharmorubicin-induced phlebitis, reduce the degree of phlebitis, and ensure the process of chemotherapy. It is worth popularizing.

  5. 中药熏蒸加外敷配合喜疗妥软膏治疗静脉炎20例%Phlebitis Treated by Traditional Chinese Medicine Fumigation and External Treatment with Hirudoid Ointment for 20 Cases

    Institute of Scientific and Technical Information of China (English)

    刘蕊

    2015-01-01

    目的 探讨中药熏蒸加外敷配合喜疗妥治疗化疗药物所致静脉炎的疗效.方法 选取我科化疗并出现静脉炎患者40例,随机分为观察组和对照组,每组20例,对照组患者给予常规硫酸镁湿敷;观察组患者给予中药熏蒸加外敷配合喜疗妥软膏治疗;观察两组患者静脉炎的治疗情况.结果 观察组患者的静脉炎治疗效果优于对照组,且治疗周期明显短于对照组.结论 运用中药熏蒸加外敷配合喜疗妥软膏涂抹按摩,对治疗化疗性静脉炎效果显著,大大减轻患者的病苦,值得临床推广.

  6. 止痛消炎膏外敷治疗流行性腮腺炎并发睾丸炎临床观察%THE CLINICAL OBSERVATION OF ANALGESIC ANTI-INFLAMMATORY OINTMENT TOPICAL TREATED MUMPS COMPLICATED ORCHITIS

    Institute of Scientific and Technical Information of China (English)

    王芳; 邓丽宁; 张伯鹏; 尚华; 张国顺; 么作义

    2014-01-01

    目的 通过对106例患者治疗方案的总结,观察止痛消炎膏外敷治疗流行性腮腺炎并发睾丸炎的临床效果.方法 2010年1月-2013年1月,该院收治的106例流行性腮腺炎并发睾丸炎患者,年龄13~35岁,平均(19.5±5.2)岁.随机数字表法分为观察组和对照组,二组均常规给予利巴韦林抗病毒,同时补液及解热镇痛等对症治疗,在此基础上观察组给予止痛消炎膏外敷睾丸.结果 观察组患者临床痊愈的时间为(6.5±1.5)d;对照组患者临床痊愈的时间为(8.2±2.2)d.二组差异有统计学意义.观察组疗效明显优于对照组.结论 止痛消炎膏外敷治疗流行性腮腺炎并发睾丸炎效果明显,简便易行,安全可靠,无不良反应.

  7. Clinical observation of treating neonatal impetigo patients by potassium permanganate combined with mupirocin ointment%高锰酸钾配合百多邦治疗新生儿脓疱疮疗效观察

    Institute of Scientific and Technical Information of China (English)

    姜洁

    2012-01-01

    目的:观察高锰酸钾配合百多邦治疗新生儿脓疱疮的效果.方法:69例脓疱疮新生儿,随机分为治疗组36例及对照组33例.治疗组在常规治疗基础上,患处给予1∶10000的高锰酸钾冷湿敷5分钟左右,后给予百多邦涂擦,每日3次;对照组在常规治疗基础上,用0.5%碘伏棉球涂擦患处,观察效果.结果:治疗组脓疱疹消退时间明显优于对照组,差异有统计学意义(P<0.05).结论:高锰酸钾配合百多邦对于新生儿脓疱疮的治疗效果满意,值得临床推广.

  8. Observation of Effect of Compound Polymyxin B Ointment in Treatment of Child Impetigo Herpetifomis%复方多粘菌素B软膏治疗儿童脓疱疮疗效观察

    Institute of Scientific and Technical Information of China (English)

    王炳文; 岳喜昂; 刘卫兵

    2009-01-01

    @@ 脓疱疮是由金黄色葡萄球菌和(或)乙型溶血性链球菌引起的一种急性化脓性皮肤病.尤以好发于夏季儿童,传染性较强,常在托儿所、幼儿园中引起流行[1].

  9. 二黄凝胶贴膏与软膏的体外释放及透皮性能比较%Comparison of Evaluation in vitro between Erhuang Gel Paste and Its Ointment

    Institute of Scientific and Technical Information of China (English)

    朱力阳; 马建; 涂禾; 向猛; 王锐

    2016-01-01

    目的 比较二黄凝胶贴膏与软膏的体外释放及透皮性能.方法 采用Strat-M膜及改进的Franz扩散池进行体外释放及透皮试验,用高效液相色谱法定量分析制剂中君药独活的有效成分蛇床子素含量,测定两种剂型的体外释放度、透皮量及透皮率.结果 二黄凝胶贴膏的透皮方程为Ln=0.443 6t+1.350 9,r=0.964 4,体外累积释放度、透皮量、透皮率分别为62.90%、0.067 2 mg/g、20.82%;二黄软膏的透皮方程为Ln=0.205 1t-0.244 7,r=0.995 6,体外累积释放度、透皮量、透皮率分别为77.64%、0.013 1 mg/g、9.36%.结论 二黄凝胶贴膏的透皮量、透皮率均优于二黄软膏,透皮性能明显优于原剂型,且凝胶贴膏不易过敏,贴敷方便.

  10. Effect observation of minocycline hydrochloride ointment for adjuvant treatment of pericoronitis%盐酸米诺环素软膏辅助治疗冠周炎的效果观察

    Institute of Scientific and Technical Information of China (English)

    宿彦品

    2014-01-01

    目的 观察盐酸米诺环素软膏辅助治疗冠周炎的临床效果.方法 将104例患者随机分为实验组和对照组各52例,实验组应用盐酸米诺环素软膏进行治疗,对照组应用碘甘油进行治疗,3d后复诊,比较两组的疗效.结果 实验组显效率为36.5%,明显高于对照组的9.6%,无效率为1.9%,明显低于对照组的15.4%,差异有统计学意义(P<0.05).结论 盐酸米诺环素软膏辅助治疗冠周炎的临床效果显著.

  11. 盐酸米诺环素软膏在智齿冠周炎治疗中的作用%Application of Minocycline Hydrochloride Ointment in Treatment to Wisdom Tooth Pericoronitis

    Institute of Scientific and Technical Information of China (English)

    张军岐

    2006-01-01

    目的:比较盐酸米诺环素软膏与碘甘油在治疗智齿冠周炎中的疗效.方法:对148例急性发作的智齿冠周炎,经常规冠周冲洗后,分别采用盐酸米诺环素软膏或者碘甘油给予冠周龈袋或者盲袋上药,借以控制或缓解智齿冠周炎的症状.并据患者炎症轻重分为同时口服抗生素组,和无辅助应用抗生素组,结果进行疗效对比,统计学分析.结果:在辅助全身应用抗生素时,两种局部处理措施的疗效基本相同;但在未给予全身抗生素治疗时,盐酸米诺环素软膏的疗效明显高于碘甘油组.结论:相对碘甘油,采用盐酸米诺环素软膏进行智齿冠周炎的治疗,具有一定的优越性.

  12. 盐酸二甲胺四环素软膏治疗急性局限性冠周炎疗效观察%Application of Minocycline Hydrochloride Ointment on the Treatment of Wisdom Tooth Pericoronitis

    Institute of Scientific and Technical Information of China (English)

    王浈

    2007-01-01

    目的 评价盐酸二甲胺四环素软膏治疗急性局限性冠周炎的临床疗效.方法 将急性局限性冠周炎92个患牙随机分成两组,在常规冠周冲洗后分别用盐酸二甲胺四环素软膏和碘甘油置冠周盲袋内治疗.结果 用药5 d后,软膏组治疗效果优于碘甘油组(P<0.01).结论 盐酸二甲胺四环素软膏对急性冠周炎的治疗效果显著,具有疗效确切,减少患者就诊次数等优点.

  13. 蜂蜡膏促进糖尿病新西兰兔创面愈合的实验研究%Experimental study on beeswax ointment in diabetic rabbit's model of wound healing

    Institute of Scientific and Technical Information of China (English)

    付辉; 王新建; 卢焕福; 徐奇玮

    2007-01-01

    [目的]观察蜂蜡膏对糖尿病新西兰兔创面愈合的影响.[方法]采用四氧嘧啶人工复制糖尿病新西兰兔模型9只,14 d后在背部各制备3个面积为2.54 cm2的全层皮肤缺损创面,将创面分为3组,即蜂蜡膏组,湿润烧伤膏组(MEBO)和空白组.通过观察残余创面面积,创面愈合时间,组织病理学量化和免疫组化结果来评价治疗效果.[结果]治疗8、12和16 d后,蜂蜡膏组创面面积较空白组明显减小(1.51±0.16)cm2、(1.80±0.11)cm2,(0.46±0.11)cm2、(1.15±0.23)cm2,(0.19±0.09)cm2、(0.59±0.19)cm2,P<0.05,愈合时间明显缩短(18.9±1.4)、(22.0±2.3)d,P<0.01.组织病理学检测蜂蜡膏组治疗的创面,成纤维细胞和新生毛细血管数量与空白组比较,差异有显著性意义(60.8±6.7、50.6±11.0,P<0.05;15.12±3.10、10.28±3.17,P<0.01).经免疫组织化学方法检测蜂蜡膏组增殖细胞核抗原(PCNA)的表达与空白组比较,差异有显著性意义(163.1±8.8、171.3±4.6,P<0.05).综合各项指标,表明蜂蜡膏组与湿润烧伤膏组药理作用强度相似.[结论]蜂蜡膏能加速糖尿病新西兰兔创面的愈合.

  14. Clobetasol Propionate Compound Ointment in the Treatment of Lichenoid Amyloidosis%复方丙酸氯倍他索软膏治疗苔藓样皮肤淀粉样变病疗效观察

    Institute of Scientific and Technical Information of China (English)

    张丽萍; 孙鸿

    2012-01-01

      目的:观察复方丙酸氯倍他索软膏治疗苔藓样皮肤淀粉样变病的疗效和安全性.方法:选取皮损位于双侧小腿且左右侧基本对称的38例患者,左侧皮损设为治疗组,右侧皮损设为对照组,分别外用复方丙酸氯倍他索软膏、0.025%全反式维甲霜,连续用药4周.结果:4周后两组基本痊愈率分别为47.37%、18.42%,有效率分别为84.21%、34.21%,两组比较差异有统计学意义(P<0.01).治疗组无不良反应发生,对照组不良反应发生率为7.89%.结论:复方丙酸氯倍他索软膏治疗苔藓样皮肤淀粉样变病安全、有效.%  Objective:Toevaluatetheefficacyandreliabilityofclobetasolpropionatecompoundointmentforthetreatmentoflichenoidamyloidosis.Methods:38patientswithlichenoidamyloidosiswhoselesiondistributedintwoshanksymmetricallywereselectedandtreatedforfourweeks,andtheleftshank(treatmentgroup)wastreatedwithclobetasolpropionatecompoundointmenttherapy,therightone(controlgroup)with0.025%all-trans-retinoicacidcream.Results:Thecurativerateswere47.37%fortreatmentgroupand18.42%forcontrolgroup.Theefficacyrateswere84.21%and34.21%,respectively,therewerestatisticaldifferenceintreatmentgroupandcontrolgroup(P<0.01)inthecurativeratesandefficacyrates.Inthetreatmentgroupsnonesideeffectswasfoundandsideeffectswerefoundin7.89%patientsofcontrolgroup.Conclusion:Clobetasolpropionatecompoundointmentisaneffectiveandsafetyagentforthetreatmentoflichenoidamyloidosis.

  15. Efficacy of Ointment Pevisone on treatment of chronic otitis externa pevisone fungal infections%派瑞松软膏治疗慢性外耳道炎真菌感染疗效观察

    Institute of Scientific and Technical Information of China (English)

    洪元庚

    2010-01-01

    目的 探讨派瑞松软膏治疗慢性外耳道炎真菌感染的疗效.方法 回顾性分析以派瑞松软膏涂抹治疗的526例慢性外耳道炎真菌感染患者的临床资料,分析致病真菌的菌种、治疗方法和疗效.结果 526例中,痊愈435例,好转49例,总有效率为92.02%.随访3个月~36个月,无复发,且有16耳鼓膜穿孔自行愈合.顽固病例42例(46耳)取耳道分泌物真菌培养,毛霉茵21例(23耳),丝状真菌15例(16耳),酵母样真菌6例(7耳).结论 派瑞松是治疗慢性外耳道炎真菌感染的有效药物之一.

  16. 氧化锌软膏治疗慢性弥漫性外耳道炎100例临床观察%Zinc ointment in the treatment of chronic otitis externa diffusa : clinical observation of 100 cases

    Institute of Scientific and Technical Information of China (English)

    孔德杰

    2013-01-01

    目的 探讨慢性弥漫性外耳道炎的临床治疗方法.方法 清洁外耳道后用氧化锌软膏均匀涂于患耳外耳道壁,两天1次,对于部分渗出较多的患者可以选择1次/d,4次为一疗程,观察疗效.结果 100例患者中治愈60例(占60%),好转33例(占33%),无效7例(占7%),总有效率93%.结论 氧化锌软膏治疗慢性弥漫性外耳道炎疗效理想,操作方便,费用低廉,建议临床上进一步推广使用.

  17. Drug: D05354 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available apeutic category: 7122 Therapeutic category of drugs in Japan [BR:br08301] 7 Agents not mainly for therape...utic purpose 71 Dispensing medicines 712 Ointment bases 7122 Emulsion bases D05354 Absorptive ointment (JP16) PubChem: 17398289 ...

  18. Drug: D05331 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D05331 Drug Yellow petrolatum (JP16); Petrolatum (USP) Pharmaceutic aid [ointment b...therapeutic purpose 71 Dispensing medicines 712 Ointment bases 7121 Oil bases D05331 Yellow petrolatum (JP16); Petrolatum (USP) CAS: 8009-03-8 PubChem: 17398284 ...

  19. The evaluation of the clinical effect of topical St Johns wort (Hypericum perforatum L.) in plaque type psoriasis vulgaris: a pilot study.

    Science.gov (United States)

    Najafizadeh, Parvaneh; Hashemian, Farshad; Mansouri, Parvin; Farshi, Susan; Surmaghi, Mohammadhossein Salehi; Chalangari, Reza

    2012-05-01

    In this case series, ten patients with plaque-type psoriasis were treated with Hypericum perforatum ointment. The hypericum ointment was applied to one side of each patient's body and the vehicle to the opposite side twice daily for 4 weeks in a single blinded manner. Modified psoriasis area severity index (PASI) scores were significantly lowered where the formulated ointment had been applied. In determining PASI scores, three factors, erythema, scaling and thickness, were evaluated; all were significantly lower where the formulated ointment had been applied (P = 0.01, P = 0.004, P = 0.04). Hypericum perforatum ointment applied twice daily may be effective in reducing PASI scores in mild plaque-type psoriasis, however, further larger studies need be conducted to achieve a more conclusive result.

  20. Clinical observation of treament of 116 patients with melasma by reduced glutathione and asiaticoside ointment%还原型谷胱甘肽联合积雪苷软膏治疗116例黄褐斑临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    张文娟; 朱云

    2014-01-01

    目的:观察还原型谷胱甘肽针辅以维生素C针联合0.25%积雪苷软膏治疗黄褐斑的疗效和安全性.方法:将入选的黄褐斑患者116例随机分成三组,积雪苷软膏治疗组、还原型谷胱甘肽治疗组、还原型谷胱甘肽联合积雪苷软膏治疗组.所有患者疗程均为8周,结束后分别观察各组疗效及不良反应.三组有效率分别为42.86%、71.05%和88.37%.同时所有患者均未见严重不良反应.结论:还原型谷胱甘肽针辅以维生素C针联合积雪苷软膏治疗黄褐斑安全、有效,可临床推广应用.

  1. The application of the treatment of resina draconis combined with chlortetracycline eye ointment and nursing intervention for the advanced cancer patients with Ⅱ period of pressure ulcers%龙血竭联合金霉素眼膏治疗晚期癌症患者Ⅱ期压疮临床观察及护理体会

    Institute of Scientific and Technical Information of China (English)

    梁丽云; 刘美荣; 张世永

    2016-01-01

    目的:探讨龙血竭联合金霉素眼膏及护理干预治疗晚期癌症患者Ⅱ期压疮的临床效果.方法:选择40例晚期癌症Ⅱ期压疮患者分为对照组和观察组,各20例,均给予0.9%氯化钠注射液棉球清洗创面,对照组采用常规护理方法及0.5%碘伏纱外敷治疗,观察组采用龙血竭联合金霉素眼膏及护理干预方法治疗.换药1次/d,1个疗程为7d,3个疗程后比较两组的临床疗效.结果:观察组出现新生健康肉芽组织时间(5.8±0.3)d,对照组出现新生健康肉芽组织时间为(7.1±0.6)d,组间比较,差异具有统计学意义(P<0.05);观察组愈合时间(14.7±0.6)d,对照组愈合时间(18.2±0.9)d,组间比较,差异具有统计学意义(P<0.05);两组治疗效果比较,差异具有统计学意义(P<0.05).结论:应用龙血竭联合金霉素眼膏及护理干预治疗晚期癌症患者Ⅱ期压疮具有显著疗效,能明显促进患者压疮愈合,缩短愈合时间.

  2. The clinical curative effect and nursing practice of compound clobetasol propionate ointment in combination with UVB irradiation on psoriasis vulgaris%复方丙酸氯倍他索软膏联合UVB治疗寻常型银屑病的临床疗效及护理

    Institute of Scientific and Technical Information of China (English)

    邢志玲; 王健

    2006-01-01

    目的 探讨用复方丙酸氯倍他索软膏联合UVB照射,并配合护理措施治疗寻常型银屑病的临床疗效.方法 治疗组于患处外涂复方丙酸氯倍他索软膏,每天2次,行UVB全身照射,1周2~3次,并配合适当的护理措施.对照组于患处外涂复方丙酸氯倍他索软膏,每天2次.根据PASI评分标准评价疗效.结果 治疗组有效率88.46%,对照组有效率65.38%,经统计学处理,x2=7.8000,P<0.01;治疗组复发率19.05%,对照组复发率53.85%,经统计学处理,x2=4.4472,P<0.05.结论 复方丙酸氯倍他索软膏联合UVB照射并配合适当的护理措施是治疗寻常型银屑病的有效方法.

  3. 冰黄肤乐软膏联合氯倍他索霜治疗寻常型银屑病临床观察%The Clinical Observation of The Combination of Binghuangfule Ointment and Clobetasol Cream for Treating Psoriasis Vulgaris

    Institute of Scientific and Technical Information of China (English)

    韩春雷; 彭建梅; 叶笑好

    2006-01-01

    目的评价冰黄肤乐软膏联合氯倍他索霜治疗寻常型银屑病临床疗效.方法治疗组43例,每日外搽冰黄肤乐软膏、氯倍他索霜各1次;对照组32例单用氯倍他索霜,2次/d.治疗后第2、第3周用PASI评分法评定疗效.结果治疗后2周,治疗组治愈率为37.21%,有效率为76.74%,对照组分别为46.87%和84.44%;治疗后3周,治疗组分别为44.19%和81.34%;对照组分别为53.13%和87.50%;两组PASI评分及上述疗效指标差异无显著性(P>0.05);治疗组出现副作用2例,对照组出现6例(P<0.01).结论冰黄肤乐软膏联合氯倍他索霜外用治疗寻常型银屑病与单用氯倍他索霜疗效相近,但副作用明显减少.

  4. 海普林乳膏联合丙酸氯倍他索软膏治疗阴囊湿疹临床疗效观察%Effective observation on treatment of eczema scrotum with the combination of heparin sodium gream and clobetasol propionate ointment

    Institute of Scientific and Technical Information of China (English)

    刘武; 万德芝

    2007-01-01

    目的 探讨海普林乳膏联合丙酸氯倍他索软膏治疗阴囊湿疹的临床效果.方法 局部用海普林乳膏联合丙酸氯倍他索软膏按1∶1比例调匀外用治疗阴囊湿疹.结果 有效率96.72%,对照组有效率80.56%,两组有显著性差异.结论 此方法治疗阴囊湿疹方便、安全、可靠、疗效肯定,值得推广应用.

  5. HPLC法测定复方咪康唑软膏中硝酸咪康唑和丙酸氯倍他索的含量%Determination of miconazole nitrate and clobetasol propionate in compound miconazole nitrate ointment by HPLC

    Institute of Scientific and Technical Information of China (English)

    谢子立; 武谷

    2001-01-01

    目的用HPLC法测定复方咪康唑复方软膏中硝酸咪康唑和丙酸氯倍他索的含量.方法以ODS为固定相,0.35%磷酸溶液(用三乙胺调节pH→3.2±0.1)-甲醇(20:80)为流动相,检测波长为240 nm,流速为1.0 ml·min-1;黄体酮为内标.结果硝酸咪康唑、丙酸氯倍他索的浓度线性范围分别为0.16~1.6 g·L-1和0.004~0.04 g·L-1,回收率分别为99.1%和100.0%.结论本法操作简便,结果准确,可以有效地控制质量.

  6. Clobetasol Propionate Compound Ointment Plus NB-UVB Phototherapy in the Treatment of Primary Cutaneous Amyloidosis:A Clinical Observation in 30 Cases%复方丙酸氯倍他索软膏联合窄谱中波紫外线治疗原发性皮肤淀粉样变病30例临床观察

    Institute of Scientific and Technical Information of China (English)

    吴晓琦; 张荷香

    2014-01-01

    目的 探讨复方丙酸氯倍他索软膏联合窄谱中波紫外线治疗原发性皮肤淀粉样变病的临床疗效和安全性.方法 将入选的60例原发性皮肤淀粉样变病患者随机分成两组,各30例.治疗组:患处外搽复方丙酸氯倍他索软膏,再予窄谱中波紫外线局部隔日照射1次,3次/周;对照组仅予窄谱中波紫外线局部照射治疗,方法同治疗组.两组患者的疗程均为4周.结果 治疗结束后,治疗组有效率为83.33%,对照组为53.33%,差异有统计学意义(P<0.05).治疗组有1例局部皮肤出现潮红、浸渍;对照组有1例出现轻微灼痛感觉.结论 复方丙酸氯倍他索软膏联合窄谱中波紫外线治疗原发性皮肤淀粉样变病比单纯使用窄谱中波紫外线治疗的效果好.

  7. 卡泊三醇软膏联合复方丙酸氯倍他索软膏治疗斑块状银屑病疗效观察%The Treatment Efficacy of Plaque Type Psoriasis Vulgaris Using Calcipotriol Cream Combined with Compound Clobetasol Propionate Ointment

    Institute of Scientific and Technical Information of China (English)

    李明鑫; 李波

    2011-01-01

    目的 观察卡泊三醇软膏及复方丙酸氯倍他索软膏治疗斑块状银屑病的疗效及安全性.方法 选择门诊斑块状寻常型银屑病患者96例,随机分治疗组及对照组各48例,治疗组每日卡泊三醇软膏及复方丙酸氯倍他索软膏早晚交替使用;对照组每日卡泊三醇乳膏及卤米松乳膏早晚交替使用,治疗前及治疗后第2、4、8周观察皮损面积及严重度指数(PASI评分)判定疗效指数,根据不良反应判定其安全性.结果 经过8周观察,治疗组有效率95.8%,对照组有效率81.3%.治疗组3例出现不良反应,对照组6例出现不良反应,症状轻微,患者均可耐受.结论 卡泊三醇和复方丙酸氯倍他索交替使用治疗斑块状银屑病见效快,不良反应轻微,可作为外用药联合使用选择方案之一.

  8. 生肌玉红膏对深Ⅱ度烧伤模型小鼠创面愈合情况及单核巨噬细胞吞噬功能的影响%Influences of Shengji Yuhong Ointment on the case of wound healing and mononuclear macrophage phagocytosis in mouse with deep partial-thickness burn

    Institute of Scientific and Technical Information of China (English)

    董小鹏; 王丽娟; 赵春霖; 于博

    2012-01-01

    目的 探讨生肌玉红膏对深Ⅱ度烧伤小鼠创面愈合的影响及对小鼠单核巨噬细胞吞噬功能的影响.方法 将30只小鼠制成深Ⅱ度烧伤模型后,随机分为烧伤模型组、美宝湿润烧伤膏(MEBO)组、生肌玉红膏组,每组10只.烧伤创面分别给予生理盐水、美宝湿润烧伤膏、生肌玉红膏治疗,2次/d.观察生肌玉红膏治疗后创面愈合情况,并用碳粒廓清法测定小鼠单核巨噬细胞吞噬功能.结果 与烧伤模型组比较,生肌玉红膏组小鼠创面愈合率提高,创面愈合时间缩短(P<0.05),单核巨噬细胞吞噬功能增强(P<0.05).结论 生肌玉红膏可有效促进烧伤创面愈合,提高单核巨噬细胞吞噬功能是其可能的作用机制之一.

  9. A randomized,double-blind,compared clinical trial of the compound lactic acid ointment in the treatment of ichthyosis vulgaris and rhagadia manus and pedalis%复方乳酸软膏治疗寻常型鱼鳞病和手足皲裂症的临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    漆军; 金文; 冯峥; 樊建峰; 汪明华; 周勇; 张昕; 王建平; 温海鹰

    2006-01-01

    目的:观察复方乳酸软膏治疗寻常型鱼鳞病和手足皲裂症的临床疗效和安全性.方法:采用随机双盲、基质对照的临床试验方法,结合开放临床试验,对复方乳酸软膏2次/d外用进行观察.结果:97例患者随机分为试验组、对照组和开放组,28d治疗后,试验组鱼鳞病和手足皲裂的有效率均为100%、对照组则分别为91.7%和27.3%.两组临床疗效有显著差异.开放组鱼鳞病和手足皲裂的有效率分别为95.7%、95.8%.复方乳酸软膏的不良事件为1.37%.结论:复方乳酸软膏治疗寻常型鱼鳞病和手足皲裂症的临床疗效优于软膏基质,其安全性与软膏基质类似.

  10. 复方乳酸软膏治疗寻常型鱼鳞病随机双盲基质对照多中心临床研究%Double blind randomized controlled clinical trial of lactic acid compound ointment in the treatment of ichthyosis vulgaris

    Institute of Scientific and Technical Information of China (English)

    季素珍; 汪科; 陈喜雪; 漆军; 李明; 彭振辉; 施秀明; 朱学骏

    2003-01-01

    目的评价复方乳酸软膏治疗寻常型鱼鳞病的疗效和安全性.方法用随机、基质对照临床试验,共126例,其中试验组62例,对照组64例,局部用药,每日2次,共用4周.结果客观指标为鳞屑、角化、皲裂,试验组和对照组有效率分别为100.0%和73.3%;主观指标为干燥、瘙痒、疼痛,试验组和对照组有效率分别为98.4%和63.3%.各项指标比较差异均有统计学意义(P<0.001).药物不良事件仅对照组发生1例,发生率为0.8%,两组比较差异无统计学意义.结论复方乳酸软膏治疗寻常型鱼鳞病疗效高,安全性好,使用方便.

  11. Observation of The Efficacy and Safety of Compound Lactic Acid Ointment in Treating Ichthyosis Vulgaris and Rhagadia Manus et Pedis%乳酸软膏治疗寻常型鱼鳞病和手足皲裂症的疗效和安全性的观察

    Institute of Scientific and Technical Information of China (English)

    闫乎玲; 彭振辉; 郗彦萍; 王冬云; 刘平

    2004-01-01

    目的观察复方乳酸软膏治疗寻常型鱼鳞病和手足皲裂的疗效和安全性.方法采用随机双盲、空白对照的临床观察.结果复方乳酸软膏较对照基质对寻常型鱼鳞病和手足皲裂症的疗效好,治疗4周后有效率为92.3%,不良反应少.结论复方乳酸软膏对治疗鱼鳞病和手足皲裂症的疗效确切,耐受性好,安全性高,可供临床选用.

  12. 黄白痤疮膏对金黄地鼠白细胞雄激素受体及皮脂腺斑组织结构的影响%The Effect of Huangbai Acne Ointment on Androgen Receptor of Golden Hamster and Organization of Gland Spot

    Institute of Scientific and Technical Information of China (English)

    陈卫平; 刘百祥; 符逢春; 彭学著; 洪俐; 陈检芳

    2009-01-01

    目的:探讨黄白痤疮膏外用治疗寻常痤疮的作用机理.方法:选用成年雄性金黄地鼠侧腹皮脂腺斑作为动物模型,随机分3组分别采用黄白痤疮膏、5%安体舒通乳剂、蒸馏水外擦皮脂腺斑20天,观察皮脂腺斑组织结构及皮脂腺斑的大小变化;应用放射配体结合分析法测定实验地鼠白细胞雄激素受体(AR)含量,放射免疫法检测地鼠血清中睾酮的水平.结果:黄白痤疮膏与安体舒通均能明显缩小金黄地鼠皮脂腺斑,与对照组比较有显著性差异(P<0.01);黄白痤疮膏能明显的改变皮脂腺斑的显微结构,与对照组比较有显著性差异(P<0.05);黄白痤疮膏与安体舒通均具有降低金黄地鼠外周血白细胞AR,与对照组比较有显著性差异(P<0.05).结论:黄白痤疮膏能抑制皮脂腺细胞的增生和分泌功能,改变皮脂腺斑显微结构,使皮脂腺斑缩小,降低金黄地鼠外周血白细胞AR,对痤疮有良好的防治作用.

  13. 毫米波微波治疗仪联合乳香没药膏治疗PICC所致机械性静脉炎的效果观察%Effect observation on millimeter wave and microwave therapeutic apparatus combined with frankincense no ointment in treatment of mechanical phlebitis caused by PICC

    Institute of Scientific and Technical Information of China (English)

    何莉莉; 候迎辉; 王风云; 郭治; 杨玉杰

    2016-01-01

    [目的]观察毫米波微波治疗仪联合乳香没药膏治疗经外周静脉置入中心静脉导管(PICC)所致机械性静脉炎的临床疗效.[方法]将我院收治的68例PICC所致机械性静脉炎病人随机分为观察组和对照组各34例.对照组行毫米波微波治疗仪治疗,观察组行毫米波微波治疗仪联合乳香没药膏治疗.观察两组临床治疗效果,统计临床症状消失时间及复发率.[结果]观察组总有效率为88.23%,对照组为73.53%,两组比较差异具有统计学意义(x 2-4.57,P<0.05);观察组局部皮肤红肿、疼痛、灼热及静脉条索状症状消失时间均短于对照组(t值分别为-5.12,-4.16,-4.61,-4.33,P均<0.05);住院期间机械性静脉炎复发率观察组为8.82%,对照组为17.65%,两组比较差异具有统计学意义(x2=5.47,P<0.05).[结论]在毫米波微波仪常规治疗基础上联合乳香没药膏外敷能有效提高PICC所致机械性静脉炎的临床疗效,加快治愈进程,降低复发率.

  14. Influence of the Hirudoid ointment combined with far-infrared radiation on the autologous arteriovenous fistula function for patients with hemodialysis%喜疗妥软膏联合远红外线照护对血液透析患者自体动静脉内瘘功能影响的研究

    Institute of Scientific and Technical Information of China (English)

    王海燕; 黄云辉; 黎利珍; 胡秀梅; 王立平

    2014-01-01

    目的 探讨喜疗妥软膏联合远红外线照护对血液透析的患者自体动静脉内瘘功能的影响.方法 将180例采用自体动静脉内瘘进行长期血液透析患者随机分为对照组和观察组,每组90例,对照组采用局部喜疗妥软膏外涂,观察组采用局部喜疗妥外涂联合远红外线照护.比较两组患者治疗3个月后血管情况.结果 观察组患者治疗3个月后,在改善内痿血管弹性、提高血液透析患者自体动静脉内瘘透析时的血流量等方面均优于对照组,两组比较差异有显著意义(P<0.05).结论 血液透析患者自体动静脉内瘘护理,局部用喜疗妥外涂联合远红外线照护,效果优于局部单纯用喜疗妥外涂.

  15. 几丁糖溶液复合多磺酸黏多糖软膏对多西紫杉醇外渗性大鼠皮肤损伤的促愈效应%Effects of chitosan solution plus hirudoid ointment on skin damage caused by docetaxel extravasation in rats

    Institute of Scientific and Technical Information of China (English)

    朱其聪; 罗荣城; 戈君凤; 张正义; 徐斌

    2008-01-01

    背景:药物外渗致皮肤损伤多以冷敷、局部注射地塞米松治疗为主,疗效差.几丁糖、多磺酸黏多糖有促进皮肤损伤愈合的功能.目的:观察几丁糖溶液复合多磺酸黏多糖软膏局部外涂对多西紫杉醇外渗性损伤大鼠的防治效果.设计、时间及地点:随机分组设计、动物对照观察,于2006-04/2007-06在南方医科大学南方医院动物实验中心完成.材料:SPF级SD大鼠25只.医用几丁糖为上海其胜生物制剂有限公司产品,多磺酸黏多糖软膏为德国三共制药厂产品,注射用多西紫杉醇为江苏恒瑞医药股份有限公司产品.方法:将25只大鼠双侧侧腹部制作多西紫杉醇血管外渗模型后按随机数字表法分为5组;几丁糖组、多磺酸黏多糖组、几丁糖+多磺酸黏多糖组、生理盐水组、模型对照组.各组药物局部外涂于多西紫杉醇注射部位,3次/d,共4 d:模型对照组不作任何防治干预.主要观察指标:观察各组大鼠处理后1,5,9,13,17,21,25,29d的损伤面积和损伤愈合时间.结果:处理后1,5,9,13,17,21,25,29 d几丁糖组、多磺酸黏多糖组、几丁糖+多磺酸黏多糖组大鼠损伤面积均显著低于生理盐水组和模型对照组,差异有显著性意义(P<0.05).几丁糖组、多磺酸黏多糖组、几丁糖+多磺酸黏多糖组的创面愈合时间显著低于生理盐水组、模型对照组,差异有显著性意义(P<0.05).结论:单用几丁糖、多磺酸黏多糖软膏外涂对多西紫杉醇外渗性损伤具有一定疗效,联合用药未能提高疗效.

  16. 自制复方丹参喜疗妥软膏预防血液透析患者动静脉内瘘并发症的效果观察%Self-prescribed Compound Danshen Hirudoid Ointment in the Prevention of Complications Included by Internal Arteriovenous Fistula in MHD Patients

    Institute of Scientific and Technical Information of China (English)

    杨筱敏; 黄蔷薇; 叶白如; 谷禾; 葛红; 金领微; 郑育

    2008-01-01

    目的 探讨自制复方丹参喜疗妥软膏预防血液透析患者动静脉内瘘并发症的效果.方法 将2005年6月-2007年1月在血液净化中心使用新内瘘的维持性血液透析患者60例,采用随机数字表法随机分为对照组和观察组各30例.对照组按动静脉内瘘穿刺后常规处理,即透析结束采用弹力绷带配合指压压迫止血5 min,30 min后解除弹力绷带,指导患者在血液透析治疗结束24 h后行湿热敷和握力器锻炼,每日2~3次;观察组在对照组的基础上于透析治疗结束24 h后用自制的复方丹参喜疗妥软膏涂抹动静脉内瘘及周围皮肤组织并按摩,每日1次.观察两组内瘘在12个月内发生栓塞、狭窄、动脉瘤、局部血管硬化等并发症情况.结果 观察组与对照组动静脉内瘘血管硬化、狭窄、动脉瘤、栓塞等并发症发生情况进行比较,差异均有统计学意义(P<0.05).结论 复方丹参喜疗妥软膏能降低动静脉内瘘并发症的发生率,有效延长维持性血液透析患者内瘘的使用时间.

  17. 喜疗妥软膏配合微波照射治疗静脉留置针所致静脉炎的疗效观察%Clinical Outcomes of Hirudoid Ointment with Microwave Radiation to Phlebitis Produced by Venous Retention

    Institute of Scientific and Technical Information of China (English)

    罗琳雪; 陈丽芬; 卢健

    2011-01-01

    目的 观察喜疗妥软膏配合微波照射治疗静脉留置针所致静脉炎的疗效.方法 行静脉留置针输液引起的静脉炎患者100例,按就诊单双号随机分为观察组和对照组各50例,观察组采用喜疗妥软膏外涂静脉炎部位并按摩后加微波照射治疗;对照组采用50%的硫酸镁湿热敷治疗.观察两组静脉炎疗效、消退时间及发生皮肤过敏的情况.结果 观察组疗效显著好于对照组,静脉炎消退时间短于对照组(P<0.01),皮肤过敏反应发生率略高于对照组,但差异无统计学意义(P>0.05).结论 喜疗妥软膏配合微波照射治疗静脉留置针所致静脉炎的疗效好,使用方便、安全.

  18. 莫匹罗星软膏外用治疗金葡菌感染的脓疱疮临床观察及药敏实验初探%Clinical observation on external use of mupirocin ointment in the treatment of staphylococcal impetigo and preliminary study on drug sensitivity

    Institute of Scientific and Technical Information of China (English)

    王晓霞; 谢志红; 陆锦兰

    2001-01-01

    莫匹罗星软膏外用治疗由金黄色葡萄球菌感染的脓疱疮 34例,痊愈率达到了 100%。并同时对所分离的 34株金葡菌进行药物敏感试验,结果 34株金葡菌对青霉素全部耐药,并检测到 2例 MRSA菌株。用约含莫匹罗星 0.09± 0.005mg/片的莫匹罗星药敏纸片进行药敏试验,所有菌株的抑菌环均达到了 32mm以上。

  19. 鱼肝油氧化锌软膏联合夫西地酸乳膏治疗儿童脓疱疮疗效观察%Observation of the effect of the children impetigo treated by the cod-liver oil zinc ointment combined with the fusidic acid emulsifiable paste

    Institute of Scientific and Technical Information of China (English)

    杜丹

    2013-01-01

    目的:评价复方鱼肝油氧化锌软膏联合夫西地酸乳膏治疗儿童脓疱疮的疗效和安全性.方法:将72例儿童脓疱疮患者,随机分为两组:治疗组给予复方鱼肝油氧化锌软膏和夫西地酸乳膏混合涂于患处;对照组仅外擦夫西地酸乳膏,两组均用药2~3次/d,疗程7 d.结果:治疗组有效率100%,对照组有效率80.56%,两组疗效比较差异有统计学意义(P<0.05).结论:复方鱼肝油氧化锌软膏联合夫西地酸乳膏治疗脓疱疮比单纯使用夫西地酸乳膏疗效好.

  20. 308nm高能准分子光与他克莫司软膏治疗儿童白癜风的护理%Nursing for treating vitiligo in children by308nm high power excimer light plus Tacrolimus ointment

    Institute of Scientific and Technical Information of China (English)

    张丽君

    2016-01-01

    白癜风是一种获得性的色素性疾病,病因复杂,以局限性或泛发性色素脱失和黑素细胞选择性破坏等为特征,约有35%的白癜风患者在儿童时期发病,给患儿及家庭带来很大的心理负担。我科室采用308nm准分子光对患儿进行治疗,并给予全面护理,取得了满意的疗效。%Vitiligo is an acquired pigmentation diseases, with complex etiology, characterized by localized or generalized depigmentation and selective destruction of melanocytes. The first onset in childhood was 35% approximately, and gave children and families a great deal of stress. 308nm high power excimer light plus comprehensive nursing was given to patients, and achieved satisfactory results.

  1. 美宝湿润烧伤膏再生疗法与磺胺嘧啶银霜抗炎疗法治疗大面积烧伤的比较研究%Comparison Study of Moist Exposed Burn Ointment Regenerative Therapy with SD- Ag Cream Anti-inflammatory Therapy for Big Area Burn

    Institute of Scientific and Technical Information of China (English)

    赵贤忠; 孙记燕; 丁伟; 项铁; 方勇; 胡栋才

    2007-01-01

    目的:比较美宝湿润烧伤膏再生疗法与磺胺嘧啶银霜抗炎疗法治疗大面积烧伤的疗效.方法:选择62例大面积烧伤病人,随机分为两组,烧伤创面分别采用美宝湿润烧伤膏再生疗法(实验组)与磺胺嘧啶银霜抗炎疗法(对照组)治疗,观察两组病人休克期情况、不同深度烧伤创面的愈合时间、感染发生率、手术植皮例数及瘢痕发生率.结果:实验组病人休克期补液量明显比对照组少、尿量多于对照组(P<0.05);休克征象发生率比对照组少,但差异无显著性(P>0.05).实验组创面愈合时间、感染率、手术植皮比例及瘢痕出现率均明显低于对照组(P<0.05).结论:在大面积烧伤治疗中,美宝湿润烧伤膏再生疗法疗效优于磺胺嘧啶银霜抗炎疗法.

  2. Comparative Analysis of Therapeutic Effect of Topical Application of Minocycline Ointment and Metronidazole Gel in Treating Parodontitis%局部应用米诺环素软膏与局部应用甲硝唑凝胶治疗牙周炎的疗效对比分析

    Institute of Scientific and Technical Information of China (English)

    张家祥

    2016-01-01

    目的 对比米诺环素与甲硝唑凝胶局部治疗牙周炎的疗效.方法 将我院口腔科门诊2012年7月至2013年7月收治的126例慢性牙周炎患者按治疗方案随机分为两组,观察组(n=63)采用米诺环素治疗,对照组(n=63)采用甲硝唑凝胶局部治疗.治疗1个月后比较龈沟出血指数(SBI)、牙龈指数(GI)菌斑指数(PLI)及牙周袋探诊指数(PD),两组患者治疗的有效率以及不良反应情况.结果 治疗后,观察组患者的牙周指标较对照组有明显降低,差异有统计学意义(P<0.05);观察组总不良反应发生率明显低于对照组,差异有统计学意义(P<0.05).结论 米诺环素用于牙周炎的治疗具有有效率高,能显著改善患者的临床症状,不良反应少的优点,较甲硝唑凝胶局部治疗有更好的综合效应,值得推广.

  3. Detetmination of Camphor and Menthol in Compound Dexamethasone Ointment By Vino Analyzing Capillary%酒成分分析柱测定复方地塞米松乳膏中樟脑、薄荷脑含量的研究

    Institute of Scientific and Technical Information of China (English)

    熊泽; 姜武民; 徐红霞; 胡斌; 李啸; 王川; 仇敏

    2009-01-01

    建立同时测定复方地塞米松乳膏中樟脑,薄荷脑含量的高效毛细管气相色谱法.以萘作内标物.采用AT.PEG-20M、50m×0.25mm×0.5u、涂布度10%的石英毛细管柱[1](酒精成分分析柱),以氢火焰离子检测器(FID)检测;柱温180℃,进样口和检测器温度分别为230℃、240℃.该色谱条件下,樟脑、薄荷脑在0.08~0.2mg·mL-1浓度范围内分别呈良好的线性;樟脑、薄荷脑精密度实验的RSD分别为1.91%(n=6)、1.61%(n=6);平均加样回收率实验中,樟脑回收率为99.66%、薄荷脑回收率为102.14%;最低检测限樟脑为0.216μg,薄荷脑为0.252μg.本方法快速可靠,简便易行,可用于复方地塞米松乳膏生产中的质量控制.

  4. 氟芬那酸丁酯软膏治疗儿童摩擦性苔藓样疹50例临床观察%The Clinical Efficacy of Butyl Flufenamate Ointment for the Treatment of Frictional Lichenoid Eruption in Children

    Institute of Scientific and Technical Information of China (English)

    宋俐; 袁爽; 许庆强

    2014-01-01

    目的 评价氟芬那酸丁酯治疗儿童摩擦性苔藓样疹的临床疗效和安全性.方法 将入选的100例摩擦性苔藓样疹患儿随机分为两组,各50例.治疗组予外用氟芬那酸丁酯软膏治疗,对照组予外用丁酸氢化可的松乳膏治疗.治疗3周后评价有效率和不良反应.结果 治疗组有效率为72.00%,显著高于对照组的52.00%,差异有统计学意义(P<0.05).治疗组有3例出现局部轻度红肿、灼热,瘙痒加重,对照组有2例出现轻度皮肤萎缩.结论 氟芬那酸丁酯软膏治疗儿童摩擦性苔藓样疹具有良好的临床疗效和安全性.

  5. A study of the clinical effect of Periocline ointment as an auxiliary therapy on chronic periodontitis%派丽奥软膏辅助龈下超声治疗中重度牙周炎临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    沈晓云; 王尽尧; 徐东菁; 王佳; 宋爱芬; 王宗宇; 范秀晨; 焦辉

    2009-01-01

    目的 评价派丽奥软膏(2%盐酸米诺环素软膏)辅助龈下超声治疗中、重度牙周炎的临床效果.方法 选择中度、重度慢性牙周炎患者82例,采用随机自身对照,经龈下超声根面平整后,实验组在牙周袋内置派丽奥软膏,每周1次,共4次,对照组不置药,在治疗前和治疗后2、4、8周检查菌斑指数(PLI)、龈沟出血指数(SBI)、牙周袋深度(PD).结果 治疗后实验组各指标与对照组比较明显下降,疗效优于对照组.结论 派丽奥软膏辅助龈下超声治疗中、重度慢性牙周炎疗效显著.

  6. 耳内镜下复方酮康唑、氧化锌软膏治疗慢性外耳道炎的临床疗效%Under endotoscope compound ketoconazole and zinc oxide ointment in the treatment of chronic otitis externa

    Institute of Scientific and Technical Information of China (English)

    李慧

    2016-01-01

    目的 分析耳内镜下复方酮康唑、氧化锌软膏治疗慢性外耳道炎的临床疗效.方法 选取2015年3月至2016年3月在我院治疗的90例慢性外耳道炎患者为研究对象,将其随机分为对照组和研究组,每组45例.对照组患者采用氧氟沙星滴耳液治疗,研究组在耳内镜下采用复方酮康唑、氧化锌软膏治疗,对比两组患者临床疗效.结果 研究组患者临床治疗有效率明显高于对照组患者(P<0.05);研究组患者耳痒、分泌物、充血、糜烂临床症状评分明显低于对照组患者(P<0.05).结论 耳内镜下采用复方酮康唑和氧化锌软膏治疗慢性外耳道炎疗效确切,可显著改善患者症状,值得临床推广和应用.

  7. Spider Bites: First Aid

    Science.gov (United States)

    ... antibiotic ointment. Apply a cool compress. Use a cloth dampened with cold water or filled with ice. ... may include: At first, slight swelling and faint red marks Intense pain and stiffness Severe abdominal pain ...

  8. Reduction of the olfactory cognitive ability in horses during preslaughter: stress-related hormones evaluation.

    Science.gov (United States)

    Micera, Elisabetta; Moramarco, Angela Maria; Zarrilli, Antonia

    2012-01-01

    As horses may perceive several odour signals of danger at slaughter, application of mentholated ointment to their nostrils may limit their perception of danger. To assess the effect of the application of a mentholated ointment to horse nostrils on the stress response during pre-slaughter handling, plasma levels were evaluated for cortisol, beta-endorphin, epinephrine and norepinephrine prior to and after stunning. Twenty draught-type horses were divided into control (n=10) and treated (n=10) groups and a mentholated ointment applied to the nostrils of the treated horses following blood sampling in lairage 45 min prior to slaughter. Treatment did not affect plasma concentrations of beta-endorphin or cortisol but significantly reduced the concentrations of epinephrine and norepinephrine observed in post-stun plasma. These results indicated that mentholated ointment applied to the nostrils of horses pre-slaughter reduced their adrenergic response to the slaughter environment, implying that the stress response may be reduced with this technology.

  9. Atopic dermatitis - children - homecare

    Science.gov (United States)

    ... medicines: The provider will probably prescribe a mild cortisone (steroid) cream or ointment at first. Topical steroids ... your child's skin is carefully exposed to ultraviolet (UV) light Short-term use of systemic steroids (steroids ...

  10. Body Piercing

    Science.gov (United States)

    ... caught on towels but won’t on disposable paper products. Avoid over cleaning. This will likely break down your skin and delay healing. Do NOT use antibacterial ointments because they don’t allow air to ...

  11. Menthol poisoning

    Science.gov (United States)

    Menthol is used to add peppermint flavor to candy and other products. It is also used in certain skin lotions and ointments. This article discusses menthol poisoning from swallowing pure menthol. This article is ...

  12. A Double-Blind, Randomized, Controlled Trial of Topical Polysporin Triple Compound Versus Topical Mupirocin for the Eradication of Colonization with Methicillin-Resistant Staphylococcus aureus in a Complex Continuing Care Population

    Directory of Open Access Journals (Sweden)

    S O’Grady

    2009-01-01

    Full Text Available BACKGROUND: Intranasal mupirocin or Polysporin Triple (PT ointment (polymyxin B, bacitracin, gramicidin, in combination with chlorhexidine body washes, have been used for eradicating methicillin-resistant Staphylococcus aureus (MRSA, but no comparative studies have been done.

  13. Wound healing activity of Sida cordifolia Linn. in rats.

    Science.gov (United States)

    Pawar, Rajesh S; Chaurasiya, Pradeep K; Rajak, Harish; Singour, Pradeep K; Toppo, Fedelic Ashish; Jain, Ankit

    2013-01-01

    The present study provides a scientific evaluation for the wound healing potential of ethanolic (EtOH) extract of Sida cordifolia Linn. (SCL) plant. Excision, incision and burn wounds were inflicted upon three groups of six rats each. Group I was assigned as control (ointment base). Group II was treated with 10% EtOH extract ointment. Group III was treated with standard silver sulfadiazine (0.01%) cream. The parameters observed were percentage of wound contraction, epithelialization period, hydroxyproline content, tensile strength including histopathological studies. It was noted that the effect produced by the ethanolic extract of SCL ointment showed significant (P < 0.01) healing in all wound models when compared with the control group. All parameters such as wound contraction, epithelialization period, hydroxyproline content, tensile strength and histopathological studies showed significant (P < 0.01) changes when compared with the control. The ethanolic extract ointment of SCL effectively stimulates wound contraction; increases tensile strength of excision, incision and burn wounds.

  14. Prostate radiation - discharge

    Science.gov (United States)

    ... Pat your skin dry. Ask your provider what soaps, lotions, or ointments are ok to use. DO ... TJ, MacDonald R, et al. Systematic review: comparative effectiveness and harms of treatments for clinically localized prostate ...

  15. [Copper-induced change in the ESR signal of hemoglobin nitrosyl complexes in wound by the action of copper nanoparticles].

    Science.gov (United States)

    Volodina, L A; Baĭder, L M; Rakhmetova, A A; Bogoslovskaia, O A; Ol'khovskaia, I P; Glushchenko, N N

    2013-01-01

    The results concerning changes in the ESR signal of hemoglobin nitrosyl complexes in wound tissues in the course of healing by the action of ointments with copper nanoparticles (patent N2460532, Russia) are presented. It is shown that the wound healing process modified by the influence of copper nanoparticles demonstrates the increase in the ESR signal amplitude for :hemoglobin nitrosyl complexes as compared with controls (the ointment base without nanoparticles). Planimetric measurements of wound area through reparation course indicate an active process of wound healing for injuries treated with copper nanoparticles in the ointment, resulting in lessening half-reparation time up to 5.0 times as compared with controls (treatment with the ointment base). The paper discusses the role of copper nanoparticles, NO and their potential synergistic effect on the skin wound regeneration.

  16. Oladimeji et al., Afr J Tradit Complement Altern Med. (2015) 12(5 ...

    African Journals Online (AJOL)

    Proff.Adewunmi

    (2005) demonstrated that the emulsion formulations of lippia oil was more ... water removable and water soluble type (Carter, 1987; Betageri and Prabhu, 2002). ... Six ointment bases, comprising of three absorption bases (Hydrous Wool Fat ...

  17. Twice Weekly Fluticasone Propionate Added To Emollient Maintenance Treatment To Reduce Risk Of Relapse In Atopic Dermatitis: Randomised, Double Blind, Parallel Group Study

    National Research Council Canada - National Science Library

    John Berth-Jones; Robert J. Damstra; Stefan Golsch; John K. Livden; Oliver Van Hooteghem; Fulvio Allegra; Christine A. Parker

    2003-01-01

    Objective To explore the efficacy and safety of fluticasone propionate, cream and ointment, applied twice weekly in addition to maintenance treatment with emollients, in reducing the risk of relapse...

  18. Neomycin Topical

    Science.gov (United States)

    Neomycin, an antibiotic, is used to prevent or treat skin infections caused by bacteria. It is not ... Neomycin comes in cream and ointment that is applied to the skin. Neomycin usually is used one ...

  19. EVALUATION OF WOUND HEALING ACTIVITY OF CROSSANDRA INFUNDIBULIFORMIS FLOWER EXTRACT ON ALBINO RATS

    Directory of Open Access Journals (Sweden)

    Rohit Gundamaraju* and T. Mohan Verma

    2012-11-01

    Full Text Available Crossandra infundibuliformis belonging to family Acanthaceae is well known medicinal plant in various region of India. This plant is one of the most chosen variety for folk medicine. Flower extract used in various conditions like fever, headache, aperitif, pain etc. Present study is concern mainly with evaluation of wound healing activity of flower ethanolic extract in Wistar rats using excision wound model in the form of ointment using two concentrations (2 and 4%w/w ointment of flower extract in simple ointment base. Both concentration of ethanolic extract showed significant response in both the wound type tested when compared with control group. 4% w/w concentration has showed better significant value than the standard drug. Nitrofurazone ointment (0.2%w/w was used as standard drug.

  20. prescribing hadits in church-owned primary health care facilities in ...

    African Journals Online (AJOL)

    2001-10-02

    Oct 2, 2001 ... SALAAM AND OTHER TANZANIAN COAST REGIONS. A.Y. MASSELE ... Patient care indicators were measured by recording consultation time .... capsules/eye ointments magnesium trisilicate tablets and mebendazole ...

  1. Bullous Keratopathy

    Science.gov (United States)

    ... cloudy cornea with blisters on the surface. Treatment Salty eye drops Drugs to lower pressure in the ... and treatment—surgical and nonsurgical—of eye disorders). Salty eye drops (hypertonic saline) and salty ointments are ...

  2. Zinc oxide overdose

    Science.gov (United States)

    Zinc oxide is an ingredient in many products. Some of these are certain creams and ointments used ... prevent or treat minor skin burns and irritation. Zinc oxide overdose occurs when someone eats one of ...

  3. Atropine Ophthalmic

    Science.gov (United States)

    ... eye examinations to dilate (open) the pupil, the black part of the eye through which you see. ... hands thoroughly with soap and water. Use a mirror or have someone else apply the ointment. Avoid ...

  4. Efficacy of single application of topical doxycycline hyclate and triamcinolone acetonide in denture adhesive in the management of recurrent aphthous stomatitis: A comparative study

    Directory of Open Access Journals (Sweden)

    Rakhi Chandak

    2017-01-01

    Conclusion: Healing of the ulcer was significantly faster with doxycycline treatment compared to triamcinolone ointment with no adverse effects. Doxycycline is proved to be one of the modalities for the treatment of aphthous ulcer.

  5. Tobramycin Ophthalmic

    Science.gov (United States)

    ... hands thoroughly with soap and water. Use a mirror or have someone else apply the ointment. Avoid ... not go away: eye tearing itching, stinging, or burning of the eye swelling of the eye temporary ...

  6. Neomycin, Polymyxin, and Bacitracin Ophthalmic

    Science.gov (United States)

    ... hands thoroughly with soap and water. Use a mirror or have someone else apply the ointment. Avoid ... symptoms, call your doctor immediately: eye pain irritation, burning, itching, swelling, or redness of the eye or ...

  7. Diarrhea: Cancer-Related Causes and How to Cope

    Science.gov (United States)

    ... be sure to gently dry the area too. Water-repellent ointments can also help keep skin irritation to ... opportunities Reprint Permissions A single copy of these materials may be reprinted for noncommercial personal use only. " ...

  8. Oladimeji et al., Afr J Tradit Complement Altern Med. (2015) 12(5 ...

    African Journals Online (AJOL)

    Proff.Adewunmi

    Key words: Lippia multiflora, Essential oil, Ointment formulation, Antimicrobial ..... 10 %w/w lippia oil showed a pseudo-plastic system on continuous shearing .... Adhesive and spreading properties of pharmaceutical gel composed of cellulose.

  9. Wound healing potential of Pterocarpus santalinus linn: a pharmacological evaluation.

    Science.gov (United States)

    Biswas, Tuhin Kanti; Maity, Lakshmi Narayan; Mukherjee, Biswapati

    2004-09-01

    The need for new therapeutics for wound healing has encouraged the drive to examine the nature and value of plant products. Ayurveda, the Indian traditional system of medicine, mentions the values of medicinal plants for wound healing. One of these is Pterocarpus santalinus. This article describes a pharmacological study to evaluate its toxicity as well as wound-healing potential in animal studies. Powder made from the wood of the P. santalinus tree was used to make up an ointment in a petroleum jelly base. No toxic effects were observed in 72 hours. Studies were done on punch and burn wound models on normal and diabetic rats using the test ointment, untreated and vehicle controls, and standard therapy. Physical and biochemical measurements were made. The test ointment-treated wounds healed significantly faster. On healing, collagenesis and biochemical measurements yielded supportive data. These studies permit the conclusion that the P. santalinus ointment is safe and effective in treating acute wounds in animal models.

  10. Ciprofloxacin Ophthalmic

    Science.gov (United States)

    Ciprofloxacin ophthalmic solution is used to treat bacterial infections of the eye including conjunctivitis (pinkeye; infection of ... in the clear front part of the eye). Ciprofloxacin ophthalmic ointment is used to treat conjunctivitis. Ciprofloxacin ...

  11. Method of the Metronidazole and Clotrimazole administration in the content of the emulsion basis

    Directory of Open Access Journals (Sweden)

    V. V. Rudenko

    2013-08-01

    Full Text Available Proved optimum method of administration of active pharmaceutical ingredients – metronidazole and clotrimazole – in the emulsion base of ointment as a suspension with vaseline oil.

  12. Drug: D01941 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available id [ointment base]; Pharmaceutic aid [suppository base]; Pharmaceutic aid [surfactant]; Pharmaceutic aid [tablet... binder and emulsifying agent]; Pharmaceutic aid [tablet coating agent] CAS: 106392-12-5 PubChem: 784900

  13. A Comparative Evaluation of Efficacy of Tacrolimus and Triamcinolone Acetonide in the Management of Symptomatic Oral Lichen Planus

    Directory of Open Access Journals (Sweden)

    Y M Swarna

    2011-01-01

    Interpretation and conclusion Topical tacrolimus 0.03% ointment induced better initial therapeutic response than triamcinolone acetonide 0.1 % ointment. However, relapses occurred in two subjects in group ′A′ and three subjects in group ′B′ after the cessation of the respective treatments. Nevertheless, at present topical tacrolimus may be a valuable addition to the already existing therapeutic modalities for treating subjects with OLP.

  14. Antiulcer Activity after Oral Administration of the Wormwood Ethanol Extract on Lesions due to Leishmania major Parasites in BALB/C Mice

    Directory of Open Access Journals (Sweden)

    Kourosh Azizi, Fatemeh Shahidi-Hakak Mohammad Djaefar Moemenbellah-Fard,\tQasem Asgari,\tSoliman Mohammadi-Samani

    2016-04-01

    Full Text Available Herbal extracts were used to investigate the in vivo efficacy of Artemisia absinthium on the treatment of cutaneous leishmaniasis in susceptible mice. A total of 40 BALB/c mice were subjected to assays. In each, 3-5×103 amastigotes of standard Leishmania major strain were inoculated subcutaneously into the tail base of mice. Groups of mice were assigned as: I-negative control, II-positive control, III-Glucantime®, IV-ointment twice a day, V-ointment with oral medicine, VI-oral medicine on parasite injection, VII-oral medicine once ulcer develops, and VIII-ointment-based crème on ulcer. The gold standard of clinical infection control was based on ulcer size measurement using a Vernier scale weekly during 4 weeks Post-Ulcer Development (PUD. The mean ulcer sizes in different groups were compared using the post hoc Dunnett's 3 statistical analyses. There was a significant difference between the two groups of ointment with medicine (V and medicine on parasite inoculation (VI (P ≤ 0.027. Antiulcer activity and healing was noted after oral treatment with aqueous extract on parasite injection. There was a significant difference between data from positive control group and local ointment with oral medicine (P ≤ 0.045 indicating that ointment use facilitated ulcer growth. There was also a significant difference between data from Glucantime® use and ointment with medicine group (P ≤ 0.039 which showed the deteriorating effect of oil-based ointment use. The oral administration of extract had an effect similar to Glucantime® use and led to the repair of ulcer. A. absinthium extract as oral feeder appeared to cause modulation of host responses, ulcer size reduction and tissue repair.

  15. Cellular signaling in sinecatechins-treated external genital and perianal warts: unraveling the mechanism of action of a botanical therapy

    Institute of Scientific and Technical Information of China (English)

    Harrison; P; Nguyen; Hung; Q; Doan; Peter; Rady; Stephen; K; Tyring

    2015-01-01

    <正>Dear Editor,Derived from green tea leaves,sinecatechins(Veregen)ointment,15%is a topical therapy that is FDA-approved to treat human papillomavirus(HPV)-induced external genital and perianal warts(EGW)in immunocompetent patients aged 18 years and older.In two phase 3 trials enrolling over 1,000 participants with EGW,a 16-week treatment regimen with sinecatechins ointment resulted in higher rates of complete clearance of all warts—both

  16. Influence of manufacturing procedure on stability of Unguentum contra perniones preparations

    Directory of Open Access Journals (Sweden)

    Bošković Mirjana

    2005-01-01

    Full Text Available Background. Application of various technological procedures for the manufacture of officinal preparation ointment against chilblains (Unguentum contra perniones produce essential variations in the quality and stability of the final product. Changing the sequence of admixing active substances into the ointment base indicated the presence of incompatibility between the active substances, as well as between the active substances and the ointment base components. The aim was to examine the influence of various technological manufacturing procedures on quality and stability of the preparation. Methods. Changes in the samples of ointments and aqueous solutions of active substances were analyzed microscopically. Results. Microscopic analysis of hydrosoluble active substance solutions demonstrated destruction of ichthammol, induced by an acidic medium due to the dissolution of tannin and resorcinol, which is well known from the literature. It also demonstrated the destruction of tannin and resorcinol in aqueous solution, which had not been described in the literature. Application of the prescribed procedure for the manufacturing of ointment against chilblains, conceals the incompatibility reactions due to a slow dissolution of the tannin suspended in the officinal ointment base Unguentum cera lanae. Admixture of an ready-made aqueous solution of tannin caused an instant contact between ichthammol and the acidic medium, which caused the destruction or the complete absence of the formation of emulsion droplets. The problem of incompatibility reactions between lanolin alcohols in the ointment base and ichthammol and resorcinol, as well as the reaction between Peruvian balsam and sulfur from the ichthammol sulfate ion was observed. Numerous incompatibility reactions of ointment against chilblains, components indicated that it was necessary to introduce alterations in both the qualitative and quantitative composition of the preparation. Conclusion. Excipient

  17. Tea tree oil as an alternative topical decolonization agent for methicillin-resistant Staphylococcus aureus.

    Science.gov (United States)

    Caelli, M; Porteous, J; Carson, C F; Heller, R; Riley, T V

    2000-11-01

    The combination of a 4% tea tree oil nasal ointment and 5% tea tree oil body wash was compared with a standard 2% mupirocin nasal ointment and triclosan body wash for the eradication of methicillin-resistant Staphylococcus aureus carriage. The tea tree oil combination appeared to perform better than the standard combination, although the difference was not statistically significant due to the small number of patients.

  18. The Role of Diltiazem enriched with Zinc sulphate in Anal Fissure

    Directory of Open Access Journals (Sweden)

    Hamoudi Mosah Alsumbouly

    2013-06-01

    Full Text Available Chronic anal fissure has traditionally been treated surgically. Initial enthusiasm for chemical sphincterotomy has waned because of poor outcomes with glyceryltrinitrate ointment. In this study the use of topical 2% diltiazem enriched with 2% Zinc sulphate ointment has been investigated as an alternative method of chemical sphincterotomy. To evaluate the effectiveness and safety of combined ointment of 2% diltiazem enriched with Zinc sulphate in the treatment of anal fissure, and to analyze the relationship between healing duration of the treatment, and the number of applications. A prospective observational study of 55 patients diagnosed with anal fissure that began treatment with three groups; control group A; using Vaseline ointment (15 cases, group B; (15 cases topical diltiazem ointment 2%, and group C; (20 cases using combined ointment diltiazem 2% enriched with Zinc sulphate 2% , between August and December 2012. Diltiazem and zinc sulphate ointment was prepared in the Pharmacy Service. Effectiveness and safety were assessed by regular visits as an outpatient management and a telephone survey conducted with each patient within 8 weeks of treatment, adding it to the patient\\s clinical records. Variables were analyzed including healing, adverse effects, duration of treatment and number of applications, among others. Follow-up was carried out for up to 3 months until complete recovery of the fissure. A total of 55 patients were included in the study , 50% of anal fissure cases were healed especially group C. Recovery occurred in 15% of patients with anal fissure in group B and in 3% of patients with anal group A. 50 % of patients fissure were cured who underwent treatment for a month or more. Treatment of chronic anal fissures with 2% diltiazem ointment enriched with Zinc sulphate 2% for two months has avoided surgery in nearly 50 % of patients, with few adverse effects. [J Intercult Ethnopharmacol 2013; 2(3.000: 173-176

  19. Drug: D05304 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D05304 Drug White petrolatum (JP16); Petrolatum, white (USP); Moroline (TN) Pharmac...es 7121 Oil bases D05304 White petrolatum (JP16); Petrolatum, white (USP) CAS: 8009-03-8 PubChem: 17398273 ... ...ment [DR:D05239], Absorptive ointment [DR:D05354], Duratears ointment (TN), Lacri-Lube NP (TN), Refresh PM (TN), Hydrophilic petrolat...um [DR:D05332], Vusion (TN) Therapeutic category of drug

  20. In vivo antibacterial and wound healing activities of Roman chamomile (Chamaemelum nobile).

    Science.gov (United States)

    Kazemian, Hossein; Ghafourian, Sobhan; Sadeghifard, Nourkhoda; Badakhsh, Behzad; Heidari, Hamid; Taji, Asieh; Shavalipour, Aref; Mohebi, Reza; Ebrahim-Saraie, Hadi Sedigh; Houri, Hamidreza; Houshmandfar, Reza

    2016-12-30

    Today considerable number of drugs are produced from plants. Several plants with antibacterial and healing applications are used in medicine such as Roman chamomile (Chamaemelum nobile L.). Wound infection is one of the most prevalent infections among infectious disease around the world. Due to appearance of drug resistance, researchers are now paying attention to medicinal plants. Therefore, this study was designed to investigate the antimicrobial and wound healing properties of C. nobile against Pseudomonas aeruginosa using in vivo conditions. Ethanolic extract of C. nobile was provided using standard method. The 5% C. nobile ointment was prepared by dissolving lyophilized extract in eucerin. Forty five male rats were obtained from Ilam university. After anesthetization and wound creation, wounds were infected by P. aeruginosa. The rats were divided into three groups, group I was treated with C. nobile ointment, group II was treated with tetracycline ointment and the third group was treated with base gel as control group. Antibacterial and wound healing activities of C. nobile ointment was more than tetracycline ointment significantly. Our results indicated that extract of C. nobile had effective antibacterial activity and accelerates the progression of wound healing. Our study indicated that antibacterial and wound healing activities of C. nobile ointment was notable. C. nobile therapy in combination with antibiotics can also be useful because medicinal plants contents operate in synergy with antibiotics. These results revealed the value of plant extracts to control antibiotic resistant bacteria in wound infection.

  1. Wound healing potential of Althaea officinalis flower mucilage in rabbit full thickness wounds

    Institute of Scientific and Technical Information of China (English)

    Robab; Valizadeh; Ali; Asghar; Hemmati; Gholamreza; Houshmand; Sara; Bayat; Mohammad; Bahadoram

    2015-01-01

    Objective: To evaluate and practically demonstrate the in fluence of Althaea officinalis flower mucilage as a plant known in Iran’s and other Middle Eastern countries’ traditional medicine for its wound healing properties.Methods: Animals were divided into 6 groups of 5 cases including a non-treated group as the negative control group receiving no treatment, a group treated with eucerin as the positive control group, a phenytoin 1% group as a standard group treated topically with phenytoin 1% hand-made ointment, and treatment groups treated with hand-made Althaea officinalis flower mucilage(AFM) ointment in a eucerin base with different concentrations(5%, 10%, 15%).Results: Among the treatment groups, the AFM 15% ointment showed the best result.Wound healing duration was reduced by the surface application of these groups. Wound closure was completed on Days 14 and 15 in the AFM 15% ointment and phenytoin 1%groups, respectively. No significant difference was observed in healing period between these groups.Conclusions: In conclusion, AFM 15% ointment was found to reduce wound healing time without any significant difference with the phenytoin 1% ointment. The authors suggest increased AFM effectiveness in when combined with phenytoin or other effectual plants.

  2. Wound healing potential of Althaea ofifcinalis lfower mucilage in rabbit full thickness wounds

    Institute of Scientific and Technical Information of China (English)

    Robab Valizadeh; Ali Asghar Hemmati; Gholamreza Houshmand; Sara Bayat; Mohammad Bahadoram

    2015-01-01

    Objective:To evaluate and practically demonstrate the influence of Althaea ofifcinalis flower mucilage as a plant known in Iran’s and other Middle Eastern countries’ traditional medicine for its wound healing properties. Methods:Animals were divided into 6 groups of 5 cases including a non-treated group as the negative control group receiving no treatment, a group treated with eucerin as the positive control group, a phenytoin 1%group as a standard group treated topically with phenytoin 1%hand-made ointment, and treatment groups treated with hand-made Althaea ofifcinalis flower mucilage (AFM) ointment in a eucerin base with different concentrations (5%, 10%, 15%). Results:Among the treatment groups, the AFM 15%ointment showed the best result. Wound healing duration was reduced by the surface application of these groups. Wound closure was completed on Days 14 and 15 in the AFM 15% ointment and phenytoin 1% groups, respectively. No significant difference was observed in healing period between these groups. Conclusions:In conclusion, AFM 15%ointment was found to reduce wound healing time without any significant difference with the phenytoin 1% ointment. The authors suggest increased AFM effectiveness in when combined with phenytoin or other effectual plants.

  3. Antimicrobial Silver Chloride Nanoparticles Stabilized with Chitosan Oligomer for the Healing of Burns

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    Yun Ok Kang

    2016-03-01

    Full Text Available Recently, numerous compounds have been studied in order to develop antibacterial agents, which can prevent colonized wounds from infection, and assist the wound healing. For this purpose, novel silver chloride nanoparticles stabilized with chitosan oligomer (CHI-AgCl NPs were synthesized to investigate the influence of antibacterial chitosan oligomer (CHI exerted by the silver chloride nanoparticles (AgCl NPs on burn wound healing in a rat model. The CHI-AgCl NPs had a spherical morphology with a mean diameter of 42 ± 15 nm. The burn wound healing of CHI-AgCl NPs ointment was compared with untreated group, Vaseline ointment, and chitosan ointment group. The burn wound treated with CHI-AgCl NPs ointment was completely healed by 14 treatment days, and was similar to normal skin. Particularly, the regenerated collagen density became the highest in the CHI-AgCl NPs ointment group. The CHI-AgCl NPs ointment is considered a suitable healing agent for burn wounds, due to dual antibacterial activity of the AgCl NPs and CHI.

  4. Antimicrobial activity of different filling pastes for deciduous tooth treatment

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    Bruna Feltrin ANTONIAZZI

    2015-01-01

    Full Text Available Guedes-Pinto paste is the filling material most employed in Brazil for endodontic treatment of deciduous teeth; however, the Rifocort® ointment has been removed. Thus, the aim of this study was to investigate the antimicrobial potential of filling pastes, by proposing three new pharmacological associations to replace Rifocort® ointment with drugs of already established antimicrobial power: Nebacetin® ointment, 2% Chlorhexidine Gluconate gel, and Maxitrol® ointment. A paste composed of Iodoform, Rifocort® ointment and Camphorated Paramonochlorophenol (CPC was employed as the gold standard (G1. The other associations were: Iodoform, Nebacetin® ointment and CPC (G2; Iodoform, 2% Chlorhexidine Digluconate gel and CPC (G3; Iodoform, Maxitrol® ointment and CPC (G4. The associations were tested for Staphylococcus aureus (S. aureus, Streptococcus mutans (S. mutans, Streptococcus oralis (S. oralis, Enterococcus faecalis (E. faecalis, Escherichia coli (E. coli, and Bacillus subtilis (B. subtilis, using the methods of dilution on solid medium – orifice agar – and broth dilution. The results were tested using statistical analysis ANOVA and Kruskal-Wallis. They showed that all the pastes had a bacteriostatic effect on all the microorganisms, without any statistically significant difference, compared with G1. S. aureus was statistically significant (multiple comparison test of Tukey, insofar as G2 and G3 presented the worst and the best performance, respectively. All associations were bactericidal for E. coli, S. aureus, S. mutans and S. oralis. Only G3 and G4 were bactericidal for E. faecalis, whereas no product was bactericidal for B. subtilis. Thus, the tested pastes have antimicrobial potential and have proved acceptable for endodontic treatment of primary teeth.

  5. OA02.04. Wound healing property of Kanchanara [Bauhinia variegata Linn] - An experimental study.

    Science.gov (United States)

    Hiremath, Shilpa; Pradeep

    2013-01-01

    Purpose: Wound a clinical entity, is commonly seen as a result of various etiological factors like trauma etc. Kanchanara a plant origin drug. Many of the Nighantu's have mentioned vrana shodhana and vrana ropana properties of Kanchanara. Hence present study of evaluating wound healing property of Kanchanara bark in the form of churna and ointment [sikta taila base] preparations has been taken up. Method: Albino rats were the experimental model. 36 albino rats were selected and divided into 6 groups of 6 rats each. 3 groups were used for excision wound model and remaining 3 groups were used for incision wound model, one group being served as the control and remaining two group for the trial drug. Churna and ointment were used for both excision and incision groups. Albino rats were wounded under aseptic conditions using wound techniques suggested by Marton and Malone [1972] and also by hunts model[1969]. In case of excision wound area of wound was measured once in 4 days by using graph sheet. In case of incision wound tensile strength was found out by using tensinometer on 10th post wounding day. Result: The statistical values of both groups were compared with control group and it showed that: 1. Kanchanara ointment promoted epithelization, wound contraction and period of epithelization was reduced in case of excision wound. 2. In incision wound also Kanchanara ointment helps in increasing collagenation and tensile strength. Both ointment and churna group are highly significant when compared with control group. On comparison of ointment group with churna group it statistically showed insignificance. No untoward side effects were noticed during the trial and the wound, healed with minimal scar. Conclusion: Kanchanara ointment and its churna is an effective, safe and well tolerated therapy in the treatment of both excision and incision wound.

  6. Nocebo hyperalgesia: contributions of social observation and body-related cognitive styles

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    Vögtle E

    2016-04-01

    Full Text Available Elisabeth Vögtle,1 Birgit Kröner-Herwig,1 Antonia Barke21Department of Clinical Psychology and Psychotherapy, Georg-Elias-Müller-Institute for Psychology, University of Göttingen, Göttingen, 2Department of Psychology, Division of Clinical Psychology and Psychotherapy, Philipps University Marburg, Marburg, Germany Purpose: Recently, it has been shown that nocebo hyperalgesia can be acquired through observational learning. The aim of this study was to investigate socially induced nocebo hyperalgesia and its relationship with pain catastrophizing, somatic complaints, hypochondriacal concerns, and empathy. Participants and methods: Ninety-seven women (43.1±15.5 years were randomly assigned to one of the two conditions. Participants in the nocebo condition (NC watched a video in which a female model displayed more pain when an ointment was applied and less pain when no ointment was applied. In the control condition (CC, the model demonstrated low pain with and without the ointment. Subsequently, all participants received three pressure pain stimuli (60 seconds on each hand. On one hand, the ointment was applied prior to the stimulation. The order of the stimulation of the fingers (middle, index, or ring finger, the side of ointment application (left or right hand, and the side with which the stimulation began were randomized within each group and balanced across the groups. Depending on the randomization, the pressure pain application started with or without ointment and on the left or right hand. Pain ratings on a numerical rating scale (0–10 were collected. In addition, the participants completed questionnaires regarding body-related cognitive styles and empathy. Results: There was a significant difference in the pain ratings between the CC and the NC. The effect of ointment application was also significant, but no interaction between condition and ointment application was found. Only in the CC did the nocebo response correlate with

  7. Study of Antiherpetic Efficiency of Phosphite of Acycloguanosine Ableto Over come the Barrier of Resistance to Acyclovir

    Science.gov (United States)

    Andronova, V. L.; Jasko, M.V.; Kukhanova, M.K.; Galegov, G.A.; Skoblov, Yr.S.; Kochetkov, S.N.

    2016-01-01

    As has been shown previously, phosphite of acycloguanosine (Hp-ACG) exhibits equal efficacy against ACV-sensitive and ACV-resistant HSV-1 strains in cell culture. Intraperitoneal administration of Hp-ACG to model mice with herpetic encephalitis caused by HSV-1 infection was shown to be effective in protecting against death. In the present work, we continue the study of the antiviral efficiency of Hp-ACG against HSV administered non-invasively; namely in vivo, orally and in the form of ointment formulations. It has been first shown that oral administration of Hp-ACG twice daily for five days prevents systemic infection in mice caused by HSV-1. Mortality in the control group of animals was 57%. Administration of Hp-ACG at doses of 600, 800 and 1,000 mg/kg per day significantly increased the survival and median day of death of the animals compared to the placebo-treated control group. A comparative evaluation of the therapeutic efficacy parameters of polyethylene glycol-based ACV ointment and Hp-ACG ointment was carried out after a 5-day course in the model of an experimental cutaneous infection of HSV-1 in guinea pigs. It was found that Hp-ACG has a significant therapeutic effect resulting in a statistically significant reduction in the lesion’s surface area and the amount of vesicular structures. The exhibited therapeutic effect of 10% Hp-ACG in ointment form compares well with that of 5% ACG ointment. PMID:27099786

  8. WOUND HEALING ACTIVITY OF ETHANOL EXTRACT OF PSEUDARTHRIA VISCIDA LINN

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    M. Vijayabaskaran

    2011-04-01

    Full Text Available The wound healing activity of topically applied ethanol extract of Pseudarthria viscida was evaluated in wistar rat by excision wound model for a period of 12 days. The extract was prepared as ointment form (5 and 10% w/w and applied on Wistar rats. Neomycin ointment 0.5%w/w was used as standard drug. The healing of the wound was assessed by the rate of wound contraction, period of epithelialisation, skin breaking strength. Both the ointments (5% and 10% w/w of Pseudarthria viscida extract promoted the wound-healing activity significantly when compared to the standard drug. High rate of wound contraction, decrease the period for epithelialisation, high skin breaking strength were observed in animals treated with 10% w/w extract ointment when compared to the control group of animals. So ethanol extract of Pseudarthria viscida in the form of 10% ointment promote wound-healing activity better than the former concentration, 5%. The result obtained from this study indicates that ethanol extract of Pseudarthria viscida accelerates the wound healing process by decreasing the surface area of the wound.

  9. Antioxidant and wound healing potential of Pistia stratiotes L.

    Directory of Open Access Journals (Sweden)

    Megha Jha

    2012-10-01

    Full Text Available Objective: To investigate the effects of Pistia stratiotes on wound healing activity in Swiss albino mice by excision wound healing model and its antioxidant study was performed to understand the mechanism of wound healing potency.Methods: Mice were topically treated with extract formulated in ointment by using simple ointment vaseline as base. 5% and 10% (w/w ointment was applied once daily. A standard group was treated with Povidone iodine ointment topically. The area of wound was measured on 4, 6, 8, 10, 12, 14, 16 post-wounding days. The scar area on complete epithelization was measured. The parameters observed were wound contraction (mm2, epithelization period and tensile strength including histopathological studies. Antioxidant activity was determined by in vitro method-H2O2 radical scavenging. Results: Treatment of wound with ointment containing 5% and 10% (w/w extract of Pistia stratiotes exhibited significant (P < 0.001 wound healing activity when compared with control group. All parameters such as wound contraction (mm2, epithelization period and tensile strength and histopathological studies showed significant changes when compared to control. Extracts possess significant antioxidant activity compared to control group. Ascorbic acid was used as reference standard for antioxidant activity (P<0.001 vs Ascorbic acid. Conclusion: The results conclude that Pistia stratiotes has antioxidant properties, which may be responsible and favorable for faster wound healing and this plant extract may be useful in the management of wounds, it also supports its traditional use.

  10. Clinical Trial: Marine Lipid Suppositories as Laxatives

    Science.gov (United States)

    Ormarsson, Orri Thor; Geirsson, Thormodur; Bjornsson, Einar Stefan; Jonsson, Tomas; Moller, Pall; Loftsson, Thorsteinn; Stefansson, Einar

    2012-01-01

    Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from omega-3 fish oil. Our purpose was to evaluate the safety of marine lipid suppositories and ointment in healthy volunteers and to explore the laxative effect of the suppositories. Thirty healthy volunteers were randomized either to a study group administrating 30% FFA suppositories and applying 30% FFA ointment to the perianal region twice per day for two weeks, or to a control group using placebo suppositories and ointment in a double blinded manner. Results: No serious toxic effects or irritation were observed. In the study group 93% felt the urge to defecate after administration of the suppositories as compared to 37% in the control group (P = 0.001). Subsequently 90% in the study group defecated, compared to 33% in the control group (P = 0.001). Conclusion: The marine lipid suppositories and ointment were well tolerated with no significant toxic side effects observed during the study period. The suppositories have a distinct laxative effect and we aim to explore this effect in further clinical trials. PMID:23118720

  11. Efficacy of topical calcineurin inhibitors in vitiligo.

    Science.gov (United States)

    Wong, Russell; Lin, Andrew N

    2013-04-01

    Topical tacrolimus and pimecrolimus are indicated for the treatment of atopic dermatitis, but they have been studied in many off-label uses. We reviewed the English language literature to define their roles in treatment of vitiligo. Double-blind studies show that tacrolimus 0.1% ointment combined with excimer laser is superior to placebo, especially for UV resistant areas, such as bony prominences of the extremities. When used alone, tacrolimus 0.1% ointment is almost as effective as clobetasol propionate 0.05% ointment. Other studies suggest it can also be effective for facial lesions. Double blind studies show that pimecrolimus 1% cream combined with narrow band UVB is superior to placebo, especially for facial lesions. Additional studies would further clarify the role of topical calcineurin inhibitors in vitiligo. © 2013 The International Society of Dermatology.

  12. Exploring the role of curcumin containing ethanolic extract obtained from Curcuma longa (rhizomes) against retardation of wound healing process by aspirin.

    Science.gov (United States)

    Pawar, Rajesh Singh; Toppo, Fedelic Ashish; Mandloi, Avinash Singh; Shaikh, Shabnam

    2015-01-01

    The aim of the study was to assess the curcumin containing ethanolic extract (EtOH) obtained from Curcuma longa (Cl) against retardation of wound healing by aspirin. Wound healing process was retarded by administering the dose of 150 mg/kg body weight of aspirin orally for 9 days to observe the effect of EtOH obtained from Cl using excision and incision wound model in rats. The various parameters such as % wound contraction, epithelialization period, hydroxyproline, tensile strength were observed at variant time intervals and histopathological study was also performed. Curcumin containing 5% and 10% ethanolic extract ointment have shown significant (P wound healing activity against an aspirin (administered 150 mg/kg body weight orally for 9 days) retarded wound healing process. Topical application of ointment showed significant (P healing of the epidermis, increased collagen, fibroblasts and blood vessels. Ethanolic extract of Cl ointment (EtOHCl) containing 10% curcumin displayed remarkable healing process against wound retardation by aspirin.

  13. Calcipotriol versus coal tar: a prospective randomized study in stable plaque psoriasis

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, V.; Kaur, I.; Kumar, B. [Postgraduate Institute of Medicinal Education & Research, Chandigarh (India)

    2003-10-01

    Topical therapies are the first line of treatment for patients with stable plaque psoriasis (SPP) affecting a limited body surface area. Very few trials comparing newer agents, such as 0.005% topical calcipotriol, with conventional modes of therapy, such as coal tar ointment, have been reported. A prospective, right-left randomized, investigator-blinded study with a 12-week treatment period and an 8-week follow-up period was performed. It was found that 0.005% calcipotriol ointment produced a faster initial response and had better cosmetic acceptability in patients, although after a long period of treatment, i.e. 12 weeks, 5% coal tar ointment had comparable efficacy. There was no statistically significant difference in the relapse rates between the two modalities.

  14. FORMULATION AND EVALUATION OF FICUS BENGHALENSIS AND FICUS RACEMOSA AQUOUES EXTRACTS

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    Krishna Murti

    2013-01-01

    Full Text Available We intended to develop a desired ointment for treatment of wound. Main objective of this study was to formulate the ointment with different ointment bases having good consistency, better diffusion and antiseptic properties. To assess the efficacy of uniformity, viscosity, diffusivity, rheology, stability, spreadability, permeability and other physical characteristics were evaluated. Two Formulations, formulation A (Aq. extract of Ficus racemosa and B (Aqueous extract of Ficus benghalensis were prepared with same bases. Both the Formulation A and B contains hard paraffin, cetostearyl alcohol, Light liquid paraffin and microcrystalline wax. Formulation B was found better than formulation A in all aspects like spreadability, viscosity, consistency, stability, diffusibility. In conclusion, it was clearly observed that Formulation B was better than formulation A.

  15. Recent Advances in the Pharmacotherapy of Chronic Anal Fissure: An Update

    Directory of Open Access Journals (Sweden)

    Bikash Medhi

    2008-07-01

    Full Text Available Surgical sphincterotomy reduces anal tone and sphincter spasm and promotes ulcer healing. Because the surgery is associated with the side effect of faecal incontinence, pharmacological agents to treat chronic anal fissure have been explored recently. Glyceryl trinitrate (GTN ointment (0.2% has an efficacy of up to 68% in healing chronic anal fissure, but it is associated with headache as the major and most common side effect. Though botulinum toxin injected into the anal sphincter healed over 80% of chronic anal fis-sures, it is more invasive and expensive than GTN therapy. Diltiazem ointment achieved healing of chronic anal fissure comparable to 0.2% GTN ointment but was associated with fewer side effects. Other drugs that have been tried are lidocaine, the alpha-adrenergic antagonist indoramin, and the potassium channel opener minoxidil.

  16. TWO TOPICAL CALCINEURIN INHIBITORS FOR THE TREATMENT OF ATOPIC DERMATITIS IN PEDIATRIC PATIENTS: A META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS (VARIANT OF THE ARTICLE IN RUSSIAN

    Directory of Open Access Journals (Sweden)

    S.L. Chen

    2011-01-01

    Full Text Available Two new topical immunomodulators, pimecrolimus cream and tacrolimus ointment for atopic dermatitis (AD in pediatric patients, have provided alternatives to topical corticosteroids without the associated adverse events. Objective: To evaluate the efficacy and safety of tacrolimus ointment and pimecrolimus cream for the treatment of AD in pediatric patients. MEDLINE, Embase, the CNKI and Cochrane Library databases were searched up to December 2008. Additional data sources were manual searches of abstract proceedings and personal contact with investigators and pharmaceutical companies. Two investigators assessed the quality of trials with unified tables independently. Disagreements on validity assessment were resolved through discussion or consultation with the third author. Quality analysis of methodology was evaluated according to the Jadad scale, including randomization, blinding and patients’ discontinuation. Twenty trials involving 6288 infants and children with AD met the inclusion criteria. More patients using tacrolimus had a good response than those in control groups including vehicle, 1% hydrocortisone acetate and 1% pimecrolimus, the corresponding OR were (4.56; 95%CI: 2.80 to 7.44, (3.92; 95% CI: 2.96 to 5.20 and (1.58; 95% CI: 1.18 to 2.12. The effect difference between 0.03% tacrolimus and 0.1% tacrolimus ointments was not statistically significant (OR = 0.90; 95% CI: 0.55 to 1.48. The incidence of adverse events of tacrolimus ointment or pimecrolimus cream was similar to the vehicle. The major adverse events were burning and pruritus. Both tacrolimus ointment and pimecrolimus cream are safe and effective in the treatment of AD in pediatric patients. Tacrolimus ointments were superior to pimecrolimus cream.Key words: atopic dermatitis, children, meta-analysis, pimecrolimus, tacrolimus.

  17. Evaluation of wound healing property of Terminalia catappa on excision wound models in Wistar rats.

    Science.gov (United States)

    Khan, A A; Kumar, V; Singh, B K; Singh, R

    2014-05-01

    Wound is defined as the loss of breaking cellular and functional continuity of the living tissues. Management of wounds is frequently encountered with different problems. Drug resistance and toxicity hindered the development of synthetic antimicrobial agents with wound healing activity. Many plants with potent pharmacological activities may offer better treatment options viz. Terminalia chebula, Terminalia bellirica and Phyllanthus emblica formulations have shown healing activities on wounds.The present study was planned to investigate the wound healing activity of Terminalia catappa on excision wound model in rats. Ointment was prepared by using bark extract of Terminalia catappa in soft paraffin and preservative. Wistar albino rats (200-250 gm) of either sex were used in the present study. A circular wound of 2 cm in diameter was made on the depilated dorsal thoracic region of the rats under ether anesthesia in aseptic conditions. The ointment was applied for 18 days and percent wound closure observed along with the parameters viz. Epithelization, granuloma weight and scar formation. Animals were observed on 3rd, 6th, 9th, 12th, 15th and 18th post-wounding day.Wound healing activity was compared with that of control and Betadine ointment as standard drug. Animals treated with Terminalia catappa ointment exhibited 97% reduction in wound area as compared to the control animals (81%). Ointment treated wounds were found to induce epithelization faster compared to the control. In conclusion, Terminalia catappa ointment promotes significant wound healing in rats and further evaluation of this activity in humans is suggested.

  18. [Assimilation test of Malassezia furfur isolated from the environment].

    Science.gov (United States)

    Tanaka, R; Nishimura, K; Kamei, K; Murayama, S Y

    2001-01-01

    The lipophilic yeasts Malassezia species are the causative agents of tinea versicolor and known also to be a member of normal skin flora. They are commonly isolated from the skin of humans and animals, but not from the environment. This is the first report of the isolation of Malassezia sp. from the environment (a hospital floor). The results of assimilation tests of lipids and karyotyping showed that these isolates were M. furfur. They assimilated not only lipids including floor wax and car wax but also some ointments (except antifungal agents) used clinically. The results suggest that we need to take care when using such ointments to treat skin diseases.

  19. Short contact therapy in psoriasis using derobin oinment

    OpenAIRE

    Basak Prasanta; Kaur Surrinder; Kaur Inderjeet

    1990-01-01

    Derobin ointment was used for a short contact period of 30 minutes a day for the treatment of 12 patients with chronic plaque psoriasis. Full strength Derobin ointment (containing 1.15% dithranol)was used on the lesions situated on the left side, while the right side lesions were treated with Derobin oitnment diluted with yellow soft:paraffin to a concentration of 0.5% dithranol. At the end of 6 weeks, 75% patients completely cleared using either strength of Derobin. Pigm...

  20. Short contact therapy in psoriasis using derobin oinment

    Directory of Open Access Journals (Sweden)

    Basak Prasanta

    1990-01-01

    Full Text Available Derobin ointment was used for a short contact period of 30 minutes a day for the treatment of 12 patients with chronic plaque psoriasis. Full strength Derobin ointment (containing 1.15% dithranolwas used on the lesions situated on the left side, while the right side lesions were treated with Derobin oitnment diluted with yellow soft:paraffin to a concentration of 0.5% dithranol. At the end of 6 weeks, 75% patients completely cleared using either strength of Derobin. Pigmentation of the peri-lesional skin and irritation were minimal with the diluted formulation.

  1. COMPARATIVE ANALYSIS OF THE USE OF CMR POMADE (BELLISPERENIS + CALENDULA OFFICINALIS + MYRISTICASEBIFERA AND PHYSIOLOGICAL SOLUTION IN TISSUE SCARRING OF RATS (RATHUSNORVEGICUS

    Directory of Open Access Journals (Sweden)

    E. S. Fernandes

    2014-09-01

    Full Text Available Pharmaceutical market has several types of ointments that are used in animals for healing processes, arising from traumatic injuries or surgical procedures. The use of homeopathic medicines in the treatment of skin wounds has grown significantly, but no one knows for sure the efficiency of such drugs. Thus, this paper aimed to measure the drug's effectiveness CMR (Bellisperenis + Calendula officinalis Myristica sebifera in comparison to physiologic solution in treating skin wounds produced in rats. Standardized in the back of the animals on both sides (right and left evaluating the healing potential of homeopathic ointment CMR compared to saline lesions were performed.

  2. Evaluation of tetracycline raw materials and finished products found on the Kenyan market.

    Science.gov (United States)

    Muritu, J W; Kibwage, I O; Maitai, C K; Hoogmartens, J

    1994-12-01

    Contents of tetracycline, its degradation products (epitetracycline, epianhydrotetracycline, anhydrotetracycline) and a fermentation impurity (2-acetyl-2-decarboxamidotetracycline) were determined in four raw materials, 12 batches of six ointment products, four eye ointment products and nine batches of five capsule products, all sampled from the Kenyan market. The analytical method was liquid chromatography on a column packed with a poly(styrenedivinyl-benzene) material (8-microns PLRP-S 100 A). All raw materials and finished products had tetracycline contents and impurity levels within the prescribed compendial limits.

  3. 新氢松与丹皮酚软膏序贯使用联合荆肤止痒颗粒治疗婴儿湿疹61例疗效观察

    Institute of Scientific and Technical Information of China (English)

    范平

    2012-01-01

      目的观察新氢松与丹皮酚软膏序贯使用联合荆肤止痒颗粒治疗婴儿湿疹的疗效及安全性.方法治疗组61例全程口服荆肤止痒颗粒1.5 g,2次/d.第1周每天早、晚外涂新氢松软膏,中午外涂丹皮酚软膏;第2周早、晚外涂丹皮酚软膏,中午外涂新氢松软膏;第3周,早、晚外涂丹皮酚软膏.对照组59例连续外用新氢松软膏,前两周2次/d,第3周改为1次/d.两组均治疗3周判定疗效,治疗过程中观察不良反应.随访4周.结果治疗组痊愈率72.1%,对照组痊愈率54.2%(χ2=4.14,<0.05).治疗组复发率45.5%,对照组复发率71.9%(χ2=5.26,<0.01).两组均未见明显不良反应.结论新氢松与丹皮酚软膏序贯使用联合荆肤止痒颗粒治疗婴儿湿疹近、远期疗效均优于单用新氢松软膏,且安全可靠.%  Objective To study the curative effects and safety quality of the treatment in sequential use of neomycin hydrocortisone ointment and Danpifen ointment combined with Jingfuzhiyang particles for the patients with infantile eczema.Methods 61 cases of the treatment group were treated with Jingfuzhiyang particles 1.5 g,2 times/d.In the first week neomycin hydrocortisone ointment was coated in the morning and the evening per day,at noon Danpifen ointment was coated;in the second week Danpifen ointment was coated in the morning and the evening per day,at noon neomycin hydrocortisone ointment was coated;in the third week Danpifen ointment was coated in the morning and the evening per day.59 cases of the control group were given continuously neomycin hydrocortisone ointment,in the first two week for 2 times/d,in the third week for1 time/d.The two groups were treated for three weeks to determine effects.Adverse reac-tions were observed in the course of treatment,with 4 weeks of follow-up.Results The cure rate of the treatment group was 72.1%, while it was 54.2%in the control group(χ2=4.14,<0.05).The recurrence rate of the treatment group was

  4. DNA adducts in skin biopsies and 1-hydroxypyrene in urine of psoriasis patients and healthy volunteers following treatment with coal tar.

    NARCIS (Netherlands)

    Hendricksen-Roelofzen, J.H.J.; Valk, P.G.M. van der; Godschalk, R.; Dettbarn, G.; Seidel, A.; Golsteijn, L.; Anzion, R.B.; Aben, K.K.H.; Schooten, F.J.L. van; Kiemeney, L.A.L.M.; Scheepers, P.T.J.

    2012-01-01

    Coal tar ointments (CTO) are frequently used in the treatment of psoriasis and eczema, but CTO contain carcinogenic polycyclic aromatic hydrocarbons (PAH). PAH are absorbed and metabolized in the skin. In psoriasis, the skin barrier is altered and therefore, absorption and metabolism of PAH may diff

  5. Drug: D06816 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D06816 Mixture, Drug Arsenical paste (JP16) Arsenic trioxide [DR:D02106], Procaine hydrochloride [DR:D00740], Hydrophilic ointment [DR:D05237], Clove oil [DR:D06823], Medicinal carbon [DR:D03251] PubChem: 47208467 ...

  6. Cumulative irritancy in the guinea pig from low grade irritant vehicles and the angry skin syndrome

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Maibach, H I

    1980-01-01

    A 4-week open cumulative irritancy test in guinea pigs discriminated between two low grade irritant vehicles, nonionic base (anhydrous) and hydrophilic ointment. The procedure might be useful as a predictive test for low grade irritants. The angry skin syndrome was established in the guinea pigs...

  7. Effects of cholesterol-bearing pullulan (CHP)-nanogels in combination with prostaglandin E1 on wound healing.

    Science.gov (United States)

    Kobayashi, Hiroshi; Katakura, Osamu; Morimoto, Nobuyuki; Akiyoshi, Kazunari; Kasugai, Shohei

    2009-10-01

    The cholesterol-bearing pullulan (CHP)-nanogels are able to trap hydrophobic drugs or proteins inside the nanogels, which is potential in application to drug delivery system and tissue engineering. On the other hand, prostaglandin E1 (PGE1) plays important roles in wound healing and PGE1 ointment has been clinically used to treat chronic skin ulcers and wounds. The purpose of this study is to evaluate effects of CHP nanogels in combination with prostaglandin E1 on wound healing in full thickness skin defect model. A square skin defect (1 x 1 cm(2)) of full thickness was created on the dorsal of Wistar rats. The wound was treated with CHP nanogels without PGE1 (CHP group) or CHP nanogels containing with PGE1 (CHP/PGE1 group) or PGE1 ointment (PGE1 ointment group). In both CHP/PGE1 and PGE1 ointment groups, approximately 6 microg of PGE1 was applied to each wound. In the control group, the wound was untreated. The wound was evaluated in measuring wound area and histologically. In CHP/PGE1 group, the rate of wound size reduction was significantly higher than the ones of other groups. Histologically, CHP/PGE1 promoted neoepithelialization, neovascularization, and wound closure compared to the other treatments. These results suggest that CHP in combination with PGE1 can promote wound healing, which confirms the efficiency of CHP nanogels-based drug delivery system. (c) 2009 Wiley Periodicals, Inc.

  8. Quantitative analysis of oxytetracycline and its impurities by LC-MS-MS

    DEFF Research Database (Denmark)

    Lykkeberg, Anne Kruse; Halling-Sørensen, Bent; Cornett, Claus;

    2004-01-01

    % and the intraday and interday precision were lower than 7.1%. The method was applied for analysis of commercial available ointments containing OTC resulting in an acceptable quantification of OTC and the impurities in the drug preparations. The advantage of this method compared to the other separation methods...

  9. Bloodletting:a medical resource since the stone age

    Institute of Scientific and Technical Information of China (English)

    Gustavo Zubieta-Calleja(Jr)

    2004-01-01

    @@ When traditional witchcraft's resources of herbs,ointments, animal sacrifices and rituals failed "to cure" in prehistoric times, a most impressive maneuver for the patient and on -lookers was bloodletting.Something was being done albeit useless from the biomedical point of view. Not disregarding the presence of healed bones in prehistoric man, a proof of surprisingly effective medicine.

  10. The occupational exposure of dermatology nurses to polycyclic aromatic hydrocarbons - evaluating the effectiveness of better skin protection.

    NARCIS (Netherlands)

    Scheepers, P.T.J.; Houtum, J.L.M. van; Anzion, R.B.M.; Champmartin, C.; Hertsenberg, S.; Bos, R.P.; Valk, P. van der

    2009-01-01

    OBJECTIVES: We studied the uptake of polycyclic aromatic hydrocarbons (PAH) in nurses who apply ointments containing coal tar to patients and investigated the effectiveness of skin protection methods. METHODS: We determined gas-phase PAH on XAD-2 and particle-associated PAH on filters. We also used

  11. Arthritis and Rheumatic Diseases

    Science.gov (United States)

    ... can involve cold packs, ice massage, soaking in cold water, or over-the-counter sprays and ointments that cool the skin and joints. Relaxation therapy. Relaxation therapy helps reduce pain by teaching people various ways to release muscle tension throughout the body. In one method of ...

  12. Atypical Opioid Mechanisms of Control of Injury-Induced Cutaneous Pain by Delta Receptors

    Science.gov (United States)

    2016-07-01

    PNAS, 2010; Scherrer et al., Cell, 2009). Briefly, mice were placed in plastic chambers on a wire mesh grid 1 hour before testing for habituation...controlling any bleeding, a single 6-0 nylon suture was placed through the midpoint of the wound and antibiotic ointment was applied. Figure 3 shows that

  13. The healing effects of herbal preparations from Sambucus ebulus and Urtica dioica in full-thickness wound models

    Directory of Open Access Journals (Sweden)

    Esmaeil Babaei

    2017-05-01

    Conclusions: Topical ointments prepared from the extracts of U. dioica and S. ebulus and their combination possess strong wound healing properties. It is postulated that a synergistic effect may exist between the two extracts since the combination 2% showed better results than the sole extracts.

  14. Study of plasmonic nanoparticles interactions with skin layers by vibrational spectroscopy.

    Science.gov (United States)

    Jeništová, Adéla; Dendisová, Marcela; Matějka, Pavel

    2016-12-21

    The healing effects of silver and gold nanoparticles (AgNPs, AuNPs) are already known from ancient times. In addition considering to their antibacterial and anti-inflammatory effects speculations are being lead with respect to these nanoparticles (NPs) also about enhancement of skin penetration properties. In this work the interactions of pig skin (PS) layers and ointments with additions of AgNPs or AuNPs prepared by standard procedures and also by "green" synthesis in a different weight proportion by vibrational spectroscopy were studied. Spectra of untreated skin and skin treated by pure ointment were measured, as well as by ointment modified by vitamins without addition of NPs or with different proportion of NPs. Kinetics of interactions of modified ointments with skin was monitored during two hours with a five-minutes interval between each two consecutive measurements. The obtained series of spectra were analyzed by multivariate statistical methods namely Partial Least Squares (PLS), Principal Component Analysis (PCA) and Soft Independent Modelling of Class Analogy (SIMCA) which revealed observation of spectral changes in time-dependent spectra and variations of the peak intensity ratios. The study showed that the effects of quantity and type of NPs on skin penetration characteristics are evident.

  15. Domoprednate (Stermonid), a topical D-homocorticosteroid, skin atrophy and telangiectasia. A double-blind, randomized comparison with hydrocortisone butyrate, betamethasone valerate, clobetasole propionate and placebo.

    Science.gov (United States)

    Serup, J; Holm, P

    1985-01-01

    Five corticosteroid ointments and placebo were compared in 17 volunteers with regard to their influence on normal skin under occlusive conditions. Each volunteer had six simultaneous applications on the forearms and six on the back. The trial was double-blind and lasted 4 weeks. The ointments were placed in randomized order. The treatments were 0.1 and 0.03% domoprednate, 0.1% hydrocortisone butyrate, 0.1% betamethasone valerate, 0.05% clobetasole propionate and placebo. Skin thickness was measured on days 0, 7, 14, 21 and 28, transepidermal water loss on days 0, 14 and 28, while blood flow and telangiectasias were evaluated only on day 28 at termination of the trial. The skin thickness became significantly reduced on all corticosteroids, but not on placebo; 0.03% domoprednate, however, tended to have an intermediate position between placebo and the other ointments. The transepidermal water loss did not change. Rating of telangiectasia under stereomicroscope showed a significantly lower score after 0.03% domoprednate and placebo as compared to the other ointments. Assessment of telangiectasia by laser-Doppler flowmetry showed a similar tendency. It is concluded that 0.1% domoprednate is comparable to other topical corticosteroids with respect to atrophogeneity and formation of telangiectasia, but the 0.03% concentration seems to result in fewer side effects.

  16. Development and Field Test of Task-Based MOS-Specific Criterion Measures. Volume 1. Appendixes A-E

    Science.gov (United States)

    1988-04-01

    authentication Employ authentication system for message authentication Monitor emergency listening silence Impose/lift emergency listening silence Maintain radio...IRRIGATE EYES Instill eye drops/ointments/irrigations 081-831-0035 MANAGE A CONVULSIVE AND/OR SEIZING PATIENT Attend casualties during seizures 081-831-0012

  17. A pharmacological approach to first aid treatment for snakebite.

    Science.gov (United States)

    Saul, Megan E; Thomas, Paul A; Dosen, Peter J; Isbister, Geoffrey K; O'Leary, Margaret A; Whyte, Ian M; McFadden, Sally A; van Helden, Dirk F

    2011-06-26

    Snake venom toxins first transit the lymphatic system before entering the bloodstream. Ointment containing a nitric oxide donor, which impedes the intrinsic lymphatic pump, prolonged lymph transit time in rats and humans and also increased rat survival time after injection of venom. This pharmacological approach should give snakebite victims more time to obtain medical care and antivenom treatment.

  18. 46 CFR 160.041-4 - Contents.

    Science.gov (United States)

    2010-10-01

    ... splinters or foreign bodies. Don't dig. Ophthalmic ointment Apply in space formed by pulling lower eyelid... 8 in twenty-four hours. Bandage compress, 4″ and 2″ Apply as a dressing over wound. DON'T touch part... appear. Compress, adhesive, 1″ Apply as dressing over small wounds. DON'T touch part that comes...

  19. Cristina et al., Afr J Tradit Complement Altern Med. (2014) 11(3):1-6 1

    African Journals Online (AJOL)

    cadewumi

    effects that could appear in humans after the unprotected ointment ... Hair removal 24 hours before testing without skin lesions, followed by light ... H&E x 200). (all color figures have resolution of 300 ... Epidermis showed no structural changes or of thickness but compared with group 1% it .... Physical chemical and cytotoxic.

  20. Reduced costs for staphylococcus aureus carriers treated prophylactically with mupirocin and chlorhexidine in cardiothoracic and orthopaedic surgery

    NARCIS (Netherlands)

    M.M.L. van Rijen (Miranda); L.G.M. Bode (Lonneke); D.A. Baak (Diane); J.A.J.W. Kluytmans (Jan); M.C. Vos (Margreet)

    2012-01-01

    textabstractBackground: A multi centre double-blind randomised-controlled trial (M-RCT), carried out in the Netherlands in 2005-2007, showed that hospitalised patients with S. aureus nasal carriage who were treated prophylactically with mupirocin nasal ointment and chlorhexidine gluconate medicated

  1. Emulsification with microstructures

    NARCIS (Netherlands)

    Dijke, van K.C.

    2009-01-01

    A dispersion is a multiphase product in which at least one phase is dispersed into another phase. In emulsions, those phases are immiscible liquids, for example oil and water. Many products which we use in everyday life are emulsions. One can think of ointments, paints, or sun protection cream, but

  2. 21 CFR 878.4470 - Surgeon's gloving cream.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Surgeon's gloving cream. 878.4470 Section 878.4470...) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Surgical Devices § 878.4470 Surgeon's gloving cream. (a) Identification. Surgeon's gloving cream is an ointment intended to be used to lubricate the...

  3. Efficacy of Jasminum grandiflorum L. leaf extract on dermal wound healing in rats.

    Science.gov (United States)

    Chaturvedi, Adya P; Kumar, Mohan; Tripathi, Yamini B

    2013-12-01

    Wound healing is a fundamental response to tissue injury and natural products accelerate the healing process. Here, we have explored the efficacy of topical administration of an ointment, prepared by methanolic extract of Jasminum grandiflorum L. (Oleaceae) leaves, on cutaneous wound healing in rats. The topical application of the Jasminum ointment on full thickness excision wounds accelerated the healing process. Tissue growth and collagen synthesis were significantly higher determined by total hydroxyl proline, hexosamine, protein and DNA content. The response was concentration- and time-dependent, when observed on days 4, 8 and 12 after wound creation. The rate of wound healing was faster as determined by wound contraction, tensile strength and other histopathological changes. In addition, this ointment also raised the activity of superoxide dismutase (SOD) and catalase (CAT) with high GSH content and low lipid peroxidation products in wound tissue. Thus, it could be suggested that the ointment from the methanolic extract of J. grandiflorum leaf improves the rate of wound healing by enhancing the rate of collagen synthesis and also by improving the antioxidant status in the newly synthesised healing wound tissue. © 2012 The Authors. International Wound Journal © 2012 John Wiley & Sons Ltd and Medicalhelplines.com Inc.

  4. 77 FR 64715 - New Animal Drugs; Approvals; Changes of Sponsor; Change of Sponsor's Name; Change of Sponsor's...

    Science.gov (United States)

    2012-10-23

    ... rights and interest in, NADA 065-015 for VETROPOLYCIN HC (bacitracin zinc, polymyxin B sulfate, neomycin sulfate, and hydrocortisone) Ophthalmic Ointment, NADA 065-016 for VETROPOLYCIN (bacitracin zinc, neomycin... narasin Type C medicated swine feeds. (d) * * * (1) * * * (xi) * * * (B) Limitations. For broiler chickens...

  5. Transdermal opioid patches for pain treatment in ancient Greece

    DEFF Research Database (Denmark)

    Harrison, Adrian Paul; Hansen, Steen Honore'; Bartels, Else M.

    2012-01-01

    Pain treatment in ancient Greece, and through the middle ages in Europe, was to a great extent based on the expertise of the Greek physician Galen (c. 129-200 A.D.). Galen makes particular reference to "Olympic Victor's Dark Ointment" (OVDO), which is listed with a number of collyria. Galen states...

  6. Sustained Protection against Superficial Bacterial and Fungal Infection by Topical Treatment.

    Science.gov (United States)

    1974-12-31

    Crystal Violet (1%) 100 Merthiolate 85,000 Neosporin cream (neomycin, 78 gramicidin, polymyxin) Polysporin ointment (bacitracin, 450 polIymyxi n...precipitously in the first five days, practically replacing the cocci; thereafter, they proportionately diminished to about a quarter of the population. Lactose

  7. Topical tacrolimus in combination with simulated solar radiation does not enhance photocarcinogenesis in hairless mice

    DEFF Research Database (Denmark)

    Lerche, C.M.; Philipsen, P.A.; Poulsen, T.;

    2008-01-01

    tacrolimus ointment on squamous cell carcinoma formation in hairless female C3.Cg/TifBomTac immunocompetent mice exposed to solar simulated radiation (SSR). In a first experiment, mice (n = 200) had tacrolimus applied on their dorsal skin three times weekly followed by SSR (2, 4 or 6 standard erythema doses...

  8. Development and evaluation of antimicrobial herbal formulations containing the methanolic extract of Samadera indica for skin diseases.

    Science.gov (United States)

    Viswanad, Vidya; Aleykutty, N A; Jayakar, B; Zacharia, Subin Mary; Thomas, Litha

    2012-04-01

    Samadera indica Gaetrn (Simaroubaceae) is claimed to possess various pharmacological activities like antioxidant, antifungal, antitumor, antiviral, and so on, but its taste is bitter. The aim of the present study is to investigate the toxicity of the methanolic extract and to develop suitable herbal formulations of the methanolic extract of Samadera indica, having efficient antimicrobial activity. The methanolic extract prepared from the dried leaves of Samadera indica by continuous hot percolation, were used to examine the toxicity, according to the OECD 423 guidelines, in Swiss Albino mice. Topical formulations were prepared by incorporating Samadera indica (5% w / w) in an emulsifying ointment and a carbopol gel base and evaluated for physical parameters and in-vitro antimicrobial activity (S. aureus, P. aeruginosa and C. albicans). The study reveals that no animals under the study showed any clinical signs of toxicity or mortality when administered a dose of 5 - 2000 mg / kg body weight. Therefore, the maximum tolerated dose of the methanolic extract of Samadera indica was above 2000 mg / kg body weight. The formulated ointment and gel had acceptable physical parameters that showed that they were compatible with the skin, and in addition to this, these formulations passed the short-term stability studies. The in-vitro antimicrobial activity studies showed that the formulated ointment showed significantly strong (p gel. Thus, the present study concludes that the formulated ointment and gel are safe and efficient antimicrobial formulations for the topical delivery of the methanolic extract of Samadera indica.

  9. Salicylic Acid Topical

    Science.gov (United States)

    DuoPlant® Gel ... Hydrisalic® Gel ... used to cleanse the skin), cream, lotion, liquid, gel, ointment, shampoo, wipe, pad, and patch to apply ... prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. ...

  10. A SucceSSful TreATmenT Of A KenyAn cASe Of unreSpOnSive ...

    African Journals Online (AJOL)

    cOmbinATiOn Of penTOSTAm And OrAl AllOpurinOl: cASe repOrT. G. Kirigi, Bsc ... topical ointments had been administered in hospital but fresh lesions erupted with potential to .... report indicated the lesions were cystic epidermoid lesions.

  11. Emulsification with microstructures

    NARCIS (Netherlands)

    Dijke, van K.C.

    2009-01-01

    A dispersion is a multiphase product in which at least one phase is dispersed into another phase. In emulsions, those phases are immiscible liquids, for example oil and water. Many products which we use in everyday life are emulsions. One can think of ointments, paints, or sun protection cream, but

  12. Topical Treatment of Dermatophytic Lesion on Mice (Mus musculus) Model.

    Science.gov (United States)

    Sharma, Bindu; Kumar, Padma; Joshi, Suresh Chandra

    2011-06-01

    Antidermatophytic potential of three weed plants viz. Tridax procumbens L., Capparis decidua (forsk) Edgew and Lantana camara L. were explored and experimentally induced dermatophytic lesion was topically treated in mice. Microbroth dilution method was carried out for determination of MIC and MFC of different extracts of selected plants. In animal studies, mice were experimentally inoculated with Trichophyton mentagrophytes and infected animals were topically treated with 5 mg/g terbinafine and two concentrations, i.e., 5 and 10 mg/g of test extract ointment. Complete recovery from the infection was observed on 12th day of treatment for reference drug terbinafine (5 mg/g) and 10 mg/g concentration of test extract ointment whereas 5 mg/g concentration of test extract ointment showed complete cure on 16th day of treatment. Fungal burden was also calculated by culturing skin scrapings from infected animals of different groups. Test extract ointment successfully treated induced dermatophytosis in mice without any disease recurrence incidences, thereby indicating efficacy of test extract as an excellent topical antifungal agent for the cure of dermatophytosis.

  13. Development and evaluation of antimicrobial herbal formulations containing the methanolic extract of Cassia alata for skin diseases

    Institute of Scientific and Technical Information of China (English)

    Stephen Olaribigbe Majekodunmi; Akanimo Akpan Essien

    2014-01-01

    Objective: To explore the antifungal and antibacterial activity of methanolic extract of Cassiaalata(C. alata) and its formulations for skin diseases. Methods: Sundried leaves of C. alata Linn. were extracted using different solvents as follows:water, methanol, ethanol, n-hexane and lastly with acetone. The crude extract was investigated for antifungal and antibacterial activities using disc diffusion method against Coccidioidesimmitis, Exophilia dermatitidis, Aspergillus fumigatus and human pathogenic fungi Candida albicans and a group of bacteria, Staphylococcus aureus. The minimum inhibitory concentrations of the methanolic extract were determined using the agar dilution method. Herbal ointments were prepared by incorporating the methanol extract of C. alata into emulsifying ointment to obtain different concentrations of 25, 50, 100, and 200 mg/mL. Results:The methanol extraction gave the maximum extraction. The formulated C. alata ointment when compared with standard drugs nystatin and streptomycin in vitro was more effective against the microorganisms. Conclusions:This study showed that C. alata had antifungal and antibacterial activities when formulated as ointment for topical use and could, therefore, explained its folkloric use for the treatment of dermatitis.

  14. Physical Property Data Review of Selected Chemical Agents and Related Compounds: Updating Field Manual 3-9 (FM 3-9)

    Science.gov (United States)

    2003-09-01

    impurities give it the odor of camphor (2,3) Boiling Point 198 °C (extrapolated) decomposes (4) Melting Point -42 °C (5,6); Generally solidifies to a...Spersul; Spersul thiovit; Sublimed sulfur; Sulfidal; Sulforon; Sulfur flower; Sulkol; Super cosan; Sulphur; Sulsol; Sulfur atom; Sulfur ointment

  15. The Field Shower Wastewater Recycling System: Development of a Program of Instruction and Preliminary Analysis of Its Potential Health Implications.

    Science.gov (United States)

    1987-02-01

    storage batteries, magnets Protease Meat tenderizers, some detergents Parabens Antimicrobials in food and drugs Lanolin Ointments, soaps, sun lotions...monostearate olive oil, sulfonated (75%) 2 - 10 Methyl paraben Tannic acid I - 8 Lanolin Triethanolamide alkylbenzene Petrolatum sulfonate (60%) 1 - 7 para

  16. Behandeling van fimosis zonder circumcisie en reconstructie van het preputium na circumcisie. [Treatment of phimosis without circumcision and reconstruction of the prepuce following circumcision

    NARCIS (Netherlands)

    Nicolai, J.P.; Meek, M.F.

    2005-01-01

    : Phimosis of the prepuce can be treated without performing a circumcision. The most common and most effective treatment option is the local application ofcorticosteroid ointment. Should this be insufficiently effective, then the constricted ring can be interrupted with two Z-plasties, which is suff

  17. DNA adducts in skin biopsies and 1-hydroxypyrene in urine of psoriasis patients and healthy volunteers following treatment with coal tar.

    NARCIS (Netherlands)

    Hendricksen-Roelofzen, J.H.J.; Valk, P.G.M. van der; Godschalk, R.; Dettbarn, G.; Seidel, A.; Golsteijn, L.; Anzion, R.B.; Aben, K.K.H.; Schooten, F.J.L. van; Kiemeney, L.A.L.M.; Scheepers, P.T.J.

    2012-01-01

    Coal tar ointments (CTO) are frequently used in the treatment of psoriasis and eczema, but CTO contain carcinogenic polycyclic aromatic hydrocarbons (PAH). PAH are absorbed and metabolized in the skin. In psoriasis, the skin barrier is altered and therefore, absorption and metabolism of PAH may diff

  18. 76 FR 65749 - Importer of Controlled Substances; Notice of Registration

    Science.gov (United States)

    2011-10-24

    ... compliance with state and local laws, and a review of the company's background and history. Therefore...: Drug Schedule Marihuana (7360) I Poppy Straw Concentrate (9670) II The company plans to import a... trial study. In addition, the company also plans to import an ointment for the treatment of wounds which...

  19. A double-blind, randomized, clinical trial on the antileishmanial activity of a Morinda citrifolia (Noni) stem extract and its major constituents.

    Science.gov (United States)

    Sattar, Fouzia A; Ahmed, Fayaz; Ahmed, Nadeem; Sattar, Samina A; Malghani, Muhammad A K; Choudhary, Muhammad I

    2012-02-01

    A controlled study was conducted to determine the efficiency of a topical ointment prepared from the stem extract of Morinda citrifolia against cutaneous leishmaniasis. Similarly, the in vitro antileishmanial activity of morindicone and morinthone isolated from the extract were investigated against Leishmania major. These compounds displayed good activity. Out of 40 patients, 50% showed an excellent response and 30% exhibited good improvement.

  20. Chronic otorrhea caused by myospherulosis in the middle ear after tympanoplasty

    NARCIS (Netherlands)

    Honings, J.; Dammeijer, P.F.

    2013-01-01

    OBJECTIVES: Myospherulosis is a foreign body reaction induced by the application of oil-based ointments. Myospherulosis in the ear is extremely rare. Only 4 cases have been described, all of which occurred after (repeated) mastoid surgery. METHODS: We present a case of persistent otorrhea and conduc