Adapting oecd aquatic toxicity tests for use with manufactured nanomaterials: key issues and consensus recommendations

DEFF Research Database (Denmark)

Petersen, Elijah J.; Diamond, Stephen A.; Kennedy, Alan J.

2015-01-01

. Scientifically based risk assessment for MNs necessitates development of reproducible, standardized hazard testing methods such as those provided by the Organization of Economic Cooperation and Development (OECD). Currently, there is no comprehensive guidance on how to best address testing issues specific to MN...... particulate, fibrous, or colloidal properties. This paper summarizes the findings from an expert workshop convened to develop a guidance document that addresses the difficulties encountered when testing MNs using aquatic and sediment OECD test guidelines. Critical components were identified by workshop...... participants that require specific guidance for MN testing: preparation of dispersions, dose metrics, the importance and challenges associated with maintaining and monitoring exposure levels, and the need for reliable methods to quantify MNs in complex media. To facilitate a scientific advance...

OECD-FIRE PR02. OECD-FIRE database record structure

International Nuclear Information System (INIS)

Kolar, L.

2005-12-01

In the coding guidelines, the scope, format, and details of any record required to input a real fire event at a nuclear reactor unit to the international OECD-FIRE database are described in detail. The database was set up in the OECD-FIRE-PR02 code

Test Specification of A1-1 Test for OECD-ATLAS Project

International Nuclear Information System (INIS)

Kang, Kyoung-Ho; Moon, Sang-Ki; Lee, Seung-Wook; Choi, Ki-Yong; Song, Chul-Hwa

2014-01-01

In the OECD-ATLAS project, design extension conditions (DECs) such as a station blackout (SBO) and a total loss of feed water (TLOFW) will be experimentally investigated to meet the international interests in the multiple high-risk DECs raised after the Fukushima accident. The proposed test matrix for the OECD-ATLAS project is summarized in Table 1.. In this study, detailed specification of the first test named as A1-1 in the OECD-ATLAS project was described. The target scenario of the A1-1 test is a prolonged SBO with delayed supply of turbine-driven auxiliary feedwater to only SG number 2 (SG-2). A SBO is one of the most important DECs in that without any proper operator actions, a total loss of heat sink leads to core uncover, to core damage, and ultimately a core melt-down scenario under high pressure. Due to this safety importance, a SBO is considered to be a base test item of the OECD-ATLAS project. A detailed specification of the first test named as A1-1 in the OECD-ATLAS project was described. The target scenario of the A1-1 test is a prolonged SBO with delayed supply of turbine-driven auxiliary feedwater to only SG-2 in order to consider an accident mitigation measure. The pre-test analysis using MARS code was performed with an aim of setting up the detailed test procedures for A1-1 test and also gaining the physical insights for a prolonged SBO transient. In the A1-1 test, a prolonged SBO transient will be simulated with two temporal phases: Phase (I) for conservative SBO transient without supply of turbine-driven auxiliary feedwater and Phase (II) for asymmetric cooling via single trained supply of turbine-driven auxiliary feedwater

Repeated 28-day oral toxicity study of vinclozolin in rats based on the draft protocol for the "Enhanced OECD Test Guideline No. 407" to detect endocrine effects.

Science.gov (United States)

Shin, Jae-Ho; Moon, Hyun Ju; Kim, Tae Sung; Kang, Il Hyun; Ki, Ho Yeon; Choi, Kwang Sik; Han, Soon Young

2006-09-01

We performed a 28-day repeated-dose toxicity study of vinclozolin, a widely used fungicide, based on the draft protocol of the "Enhanced OECD Test Guideline 407" (Enhanced TG407) to investigate whether vinclozolin has endocrine-mediated properties according to this assay. Seven-week-old SD rats were administered with vinclozolin daily by oral gavage at dose rates of 0, 3.125, 12.5, 50 and 200 mg/kg/day for at least 28 days. The vinclozolin-treated male rats showed a reduction of epididymis and accessory sex organ weights and an alteration of hormonal patterns. A slight prolongation of the estrous cycle and changes in the estrogen/testosterone ratio and luteinizing hormone level were observed in vinclozolin-treated female rats. Thyroxin concentrations were decreased and thyroid-stimulating hormone concentrations were increased in both sexes; however, there were no compound-related microscopic lesions in the thyroid gland or changes in the thyroid weight. The endocrine-related effects of vinclozolin could be detected by the parameters examined in the present study based on the OECD protocol, suggesting the Enhanced TG407 protocol should be a suitable screening test for the detection of endocrine-mediated effects of chemicals.

'Incorporating the OECD Guidelines in International Investment Agreements: Turning a Soft Law Obligation into Hard Law?

NARCIS (Netherlands)

Zee, van der E.L.

2013-01-01

This article has been written as a response to two recent developments. First, as a response to the recent update of the Organisation for Economic Co-operation and Development (OECD) Guidelines on 25 May 2011, which seem to have taken a form based on human rights due diligence. Second, as a response

OECD validation study to assess intra- and inter-laboratory reproducibility of the zebrafish embryo toxicity test for acute aquatic toxicity testing.

Science.gov (United States)

Busquet, François; Strecker, Ruben; Rawlings, Jane M; Belanger, Scott E; Braunbeck, Thomas; Carr, Gregory J; Cenijn, Peter; Fochtman, Przemyslaw; Gourmelon, Anne; Hübler, Nicole; Kleensang, André; Knöbel, Melanie; Kussatz, Carola; Legler, Juliette; Lillicrap, Adam; Martínez-Jerónimo, Fernando; Polleichtner, Christian; Rzodeczko, Helena; Salinas, Edward; Schneider, Katharina E; Scholz, Stefan; van den Brandhof, Evert-Jan; van der Ven, Leo T M; Walter-Rohde, Susanne; Weigt, Stefan; Witters, Hilda; Halder, Marlies

2014-08-01

The OECD validation study of the zebrafish embryo acute toxicity test (ZFET) for acute aquatic toxicity testing evaluated the ZFET reproducibility by testing 20 chemicals at 5 different concentrations in 3 independent runs in at least 3 laboratories. Stock solutions and test concentrations were analytically confirmed for 11 chemicals. Newly fertilised zebrafish eggs (20/concentration and control) were exposed for 96h to chemicals. Four apical endpoints were recorded daily as indicators of acute lethality: coagulation of the embryo, lack of somite formation, non-detachment of the tail bud from the yolk sac and lack of heartbeat. Results (LC50 values for 48/96h exposure) show that the ZFET is a robust method with a good intra- and inter-laboratory reproducibility (CV30%) for some very toxic or volatile chemicals, and chemicals tested close to their limit of solubility. The ZFET is now available as OECD Test Guideline 236. Considering the high predictive capacity of the ZFET demonstrated by Belanger et al. (2013) in their retrospective analysis of acute fish toxicity and fish embryo acute toxicity data, the ZFET is ready to be considered for acute fish toxicity for regulatory purposes. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

Mobility of coated and uncoated TiO2 nanomaterials in soil columns--Applicability of the tests methods of OECD TG 312 and 106 for nanomaterials.

Science.gov (United States)

Nickel, Carmen; Gabsch, Stephan; Hellack, Bryan; Nogowski, Andre; Babick, Frank; Stintz, Michael; Kuhlbusch, Thomas A J

2015-07-01

Nanomaterials are commonly used in everyday life products and during their life cycle they can be released into the environment. Soils and sediments are estimated as significant sinks for those nanomaterials. To investigate and assess the behaviour of nanomaterials in soils and sediments standardized test methods are needed. In this study the applicability of two existing international standardized test guidelines for the testing of nanomaterials, OECD TG 106 "Adsorption/Desorption using a Bath Equilibrium Method" and the OECD TG 312 "Leaching in Soil Columns", were investigated. For the study one coated and two uncoated TiO2 nanomaterials were used, respectively. The results indicate that the OECD TG 106 is not applicable for nanomaterials. However, the test method according to OECD TG 312 was found to be applicable if nano-specific adaptations are applied. The mobility investigations of the OECD TG 312 indicated a material-dependent mobility of the nanomaterials, which in some cases may lead to an accumulation in the upper soil layers. Whereas no significant transport was observed for the uncoated materials for the double-coated material (coating with dimethicone and aluminiumoxide) a significant transport was detected and attributed to the coating. Copyright © 2015 Elsevier Ltd. All rights reserved.

Applicability of the fish embryo acute toxicity (FET) test (OECD 236) in the regulatory context of Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH).

NARCIS (Netherlands)

Sobanska, Marta; Scholz, Stefan; Nyman, Anna-Maija; Cesnaitis, Romanas; Gutierrez Alonso, Simon; Klüver, Nils; Kühne, Ralph; Tyle, Henrik; de Knecht, Joop; Dang, Zhichao; Lundbergh, Ivar; Carlon, Claudio; De Coen, Wim

In 2013 the Organisation for Economic Co-operation and Development (OECD) test guideline (236) for fish embryo acute toxicity (FET) was adopted. It determines the acute toxicity of chemicals to embryonic fish. Previous studies show a good correlation of FET with the standard acute fish toxicity

Nye OECD-retningslinjer for transfer pricing dokumentation

DEFF Research Database (Denmark)

Rossing, Christian Plesner

2015-01-01

er vedtaget, erstatte det nuværende kapitel V om transfer pricing dokumentation i ‘OECD Transfer Pricing Guidelines for Multinational Enterprises and Tax Administrations’. De gældende danske regler for transfer pricing dokumentation baserer sig på de eksisterende OECD-retningslinjer, og det må...

Local lymph node assay: how testing laboratories apply OECD TG 429 for REACH purposes.

Science.gov (United States)

Rovida, Costanza

2011-01-01

The Local Lymph Node Assay (LLNA) is the official method for assessing the allergic contact dermatitis potential of chemicals for the purposes of REACH regulation. The LLNA went through a validation process that allowed the delineation of a robust protocol for performing new tests. The OECD accepted this method in 2002 and published OECD TG 429. The European Chemical Agency (ECHA) recently published data that were submitted in the registration dossiers of chemicals. This database was analysed to determine how testing laboratories apply OECD TG 429. This analysis comes after a detailed analysis of four full study reports that were also prepared for REACH purposes. Although the majority of the tests are fully compliant with OECD TG 429, some showed major deviations, and a number of others used more animals than necessary. This suggests that in vivo tests need to be planned more carefully and consciously to obtain meaningful results with the minimum animal number necessary.

OECD Guidelines for the Testing of Chemicals, Test No. 226: Predatory mite (Hypoaspis (Geolaelaps) aculeifer) reproduction test in soil

DEFF Research Database (Denmark)

Römbke, L. Becker, B. Dark, Th. Moser, N. Halsall, W. Powley, A. Ruf, C. Scholer, E. Smit, P. Wege, N. Zenz m.fl., J.; Krogh, Paul Henning

2008-01-01

This Test Guideline describes a method to assess the effects of chemical substances in soil on the reproductive output of the soil mite species Hypoaspis (Geolaelaps) aculeifer Canestrini (Acari: Laelapidae). It can be used for water soluble or insoluble substances, but not with volatile substances...... replicates for each test concentrations and six to eight control replicates, of 10 animals each, are recommended. At 20 oC, the test lasts 14 days after introducing the females, which usually allows the control offspring to reach the deutonymph stage. The number of surviving females (mortality ...% for a valid test) and the number of juveniles per test vessel (at least 50 for a valid test) are determined. The fecundity of the mites exposed to the test substance is compared to that of controls in order to determine the ECx (e.g. EC10, EC50) or the No Observed Effect Concentration (NOEC). Any observed...

Etoposide; colchicine; mitomycin C and cyclophosphamide tested in the in vitro mammalian cell micronucleus test (MNvit) in Chinese hamster lung (CHL) cells at Covance laboratories; Harrogate UK in support of OECD draft Test Guideline 487.

Science.gov (United States)

Fowler, Paul; Whitwell, James; Jeffrey, Laura; Young, Jamie; Smith, Katie; Kirkland, David

2010-10-29

The following genotoxic chemicals were tested in the in vitro micronucleus assay, at Covance Laboratories, Harrogate, UK in the Chinese hamster lung cell line CHL. Etoposide (a topoisomerase inhibitor), colchicine (an aneugen), mitomycin C (a DNA cross linking agent) and cyclophosphamide (an alkylating agent requiring metabolic activation) were treated with and without cytokinesis block (by addition of cytochalasin B). This work formed part of a collaborative evaluation of the toxicity measures recommended in the draft OECD Test Guideline 487 for the in vitro micronucleus test. The toxicity measures used, detecting both cytostasis and cell death, were relative population doubling, relative increase in cell counts and relative cell counts for treatments in the absence of cytokinesis block, and replication index or cytokinesis blocked proliferation index in the presence of cytokinesis block. All of the chemicals tested gave significant increases in the percentage of micronucleated cells with and without cytokinesis block at concentrations giving approximately 60% toxicity (cytostasis and cell death) or less by all of the toxicity measures used. The outcomes from this series of tests support the use of relative increase in cell counts and relative population doubling, as well as relative cell counts, as appropriate measures of cytotoxicity for the non-cytokinesis blocked in vitro micronucleus assay. Copyright © 2010 Elsevier B.V. All rights reserved.

Validation report – Results of an International Ring test According to the Draft Guideline: Predatory mite reproduction test in soil (Hypoaspis (Geolaelaps) aculeifer) (med bidrag)

DEFF Research Database (Denmark)

Römbke, Jörg; Becker, B. Dark, Th. Moser, N. Halsall, W. Powley, A. Ruf, C. Scholer, E. Smit, P. Wege, N. Zenz, L.; Krogh, Paul Henning

A new Test Guideline has been developed, which is designed to be used for assessing the effects of chemical substances in soil on the reproductive output of the soil mite species Hypoaspis (Geolaelaps) aculeifer Canestrini (Acari: Laelapidae). H. aculeifer represents an additional trophic level...... to the species for which guidelines are already available. The main endpoint is the reproduction of the mites without discrimination and quantification of the different stages of the reproductive cycle. Based on already standardised OECD and ISO test guidelines as well as ideas from literature, the ad...... caused by the ring test experiences. The results determined in the ring test proved the suitability of the proposed test method. The LC50 values for both test chemicals differed by less than a factor of 2.5 from the mean and no statistically significant differences were found between laboratories.The EC...

Key transfer pricing issues arising from the transfer of an ongoing concern : A comparison between the OECD TP Guidelines and the German and the U.S. legislations

OpenAIRE

Sjöberg, Daniel

2013-01-01

The purpose of this thesis is to analyse and compare the transfer pricing approaches held by the OECD, Germany and the United States when transferring an ongoing concern. The term “ongoing concern” in the OECD Transfer Pricing Guidelines is to be interpreted as very wide and to cover every case where a function is bundled with assets and risks. Even though there is no legal definition of the term , the definition of the OECD can still be said to represent the common definition of the term. Wh...

Comparison of the sensitivities of the Buehler test and the guinea pig maximization test for predictive testing of contact allergy

DEFF Research Database (Denmark)

Frankild, S; Vølund, A; Wahlberg, J E

2001-01-01

International test guidelines, such as the Organisation for Economic Cooperation and Development (OECD) guideline #406, recommend 2 guinea pig methods for testing of the contact allergenic potential of chemicals: the Guinea Pig Maximization Test (GPMT) and the Buehler test. Previous comparisons...

Cadmium chloride, benzo[a]pyrene and cyclophosphamide tested in the in vitro mammalian cell micronucleus test (MNvit) in the human lymphoblastoid cell line TK6 at Covance laboratories, Harrogate UK in support of OECD draft Test Guideline 487.

Science.gov (United States)

Fowler, Paul; Whitwell, James; Jeffrey, Laura; Young, Jamie; Smith, Katie; Kirkland, David

2010-10-29

The following genotoxic chemicals were tested in the in vitro micronucleus assay, at Covance Laboratories, Harrogate, UK in the human lymphoblastoid cell line TK6. Cadmium chloride (an inorganic carcinogen), benzo[a]pyrene (a polycyclic aromatic hydrocarbon requiring metabolic activation) and cyclophosphamide (an alkylating agent requiring metabolic activation) were treated with and without cytokinesis block (by addition of cytochalasin B). This work formed part of a collaborative evaluation of the toxicity measures recommended in the draft OECD Test Guideline 487 for the in vitro micronucleus test. The toxicity measures used, capable of detecting both cytostasis and cell death, were relative population doubling, relative increase in cell counts and relative cell counts for treatments in the absence of cytokinesis block, and replication index or cytokinesis blocked proliferation index in the presence of cytokinesis block. All of the chemicals tested gave significant increases in the percentage of micronucleated cells with and without cytokinesis block at concentrations giving approximately 60% toxicity (cytostasis and cell death) or less by all of the toxicity measures used. The outcomes from this series of tests support the use of relative increase in cell counts and relative population doubling, as well as relative cell counts, as appropriate measures of cytotoxicity for the non-cytokinesis blocked in the in vitro micronucleus assay. Copyright © 2010 Elsevier B.V. All rights reserved.

A critical comparison of respirometric biodegradation tests based on OECD 301 and related test methods.

Science.gov (United States)

Reuschenbach, Peter; Pagga, Udo; Strotmann, Uwe

2003-04-01

Biodegradation studies of organic compounds in the aquatic environment gain important information for the final fate of chemicals in the environment. A decisive role play tests for ready biodegradability (OECD 301) and in this context, the respirometric test (OECD 301F). Two different respirometric systems (Oxitop and Sapromat) were compared and in two of ten cases (diethylene glycol and 2-ethylhexylacrylate) differences were observed indicating that the test systems are not always equivalent. For 2-ethylhexylacrylate and cyclohexanone we could not state differences in the extent of biodegradation with a municipal and industrial inoculum whereas for cyclohexanone the degradation rate was faster with a municipal inoculum. Allylthiourea (ATU) proved to be an effective inhibitor of nitrification processes and did not affect the heterotrophic biodegradation activity. Modelling of biodegradation processes could be successfully performed with a first-order and a modified logistic plot. Copyright 2002 Elsevier Science Ltd.

Experimental Results of A1.1 Test for OECD-ATLAS Project

Energy Technology Data Exchange (ETDEWEB)

Kang, Kyoung-Ho; Bae, Byoung-Uhn; Park, Yu-Sun; Kim, Jong-Rok; Choi, Nam-Hyun; Choi, Ki-Yong [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2015-10-15

KAERI (Korea Atomic Energy Research Institute) is operating an OECD/NEA project (hereafter, OECD-ATLAS project) by utilizing a thermal-hydraulic integral effect test facility, ATLAS (Advanced Thermal-hydraulic Test Loop for Accident Simulation). Considering the importance of the SBO scenario and the related accident mitigation measures, a prolonged SBO scenario was selected as the first test subject worthy of investigation in the OECD-ATLAS project as summarized in Table 1. After the Fukushima accident, design extension conditions (DECs) such as an SBO and a total loss of feed water (TLOFW) attracted wide international attention in that such high-risk multiple failure accidents should be revisited from the viewpoint of the reinforcement of the 'defense in depth' concept. In particular, an SBO is one of the most important DECs because a total loss of heat sink can lead to a core melt-down scenario under high pressure without any proper operator action. As for a prolonged SBO transient of the OECD-ATLAS project, two tests, named A1.1 and A1.2, were determined to be performed. In most nuclear power plants (NPPs), a turbine-driven auxiliary feedwater system was designed to remove the decay heat during the early period of an SBO transient. From a conservative point of view, however, it is necessary to investigate the thermal-hydraulic behaviors of the NPP when a turbine-driven auxiliary feedwater supply is not available during the initial period of an SBO transient and moreover a mobile pump-driven auxiliary feedwater supply can only become realized in the later period of the scenario. In particular, asymmetric heat removal characteristic through the supply of auxiliary feedwater only to one steam generator has its own peculiar importance in terms of safety analysis code validation. With an aim of considering these safety importance, in the A1.1 test, a prolonged SBO transient was simulated with two temporal phases: Phase (I) for a conservative SBO transient

Translation of the UNESCO/OECD Guidelines for Quality Provision in Cross-Border Higher Education into Local Policy Contexts: A Comparative Study of Finland and Russia

Science.gov (United States)

Kallo, Johanna; Semchenko, Anzhelika

2016-01-01

This article analyses the localisation of the United Nations Educational Scientific and Cultural Organisation (UNESCO)/Organisation for Economic Co-operation and Development (OECD) "Guidelines for Quality Provision in Cross-Border Higher Education" (2005) at the national and university levels in Finland and Russia. The article engages…

Coal Consumption and Economic Growth: Panel Cointegration and Causality Evidence from OECD and Non-OECD Countries

Directory of Open Access Journals (Sweden)

Taeyoung Jin

2018-03-01

Full Text Available This paper examines the relationship between coal consumption and economic growth for 30 OECD (Organisation for Economic Co-operation and Development countries and 32 non-OECD countries for 1990–2013 using a multivariate dependent panel analysis. For the analysis, we conducted the common factor defactorization process, unit root test, cointegration test, long-run cointegrating vector, and Granger causality test. Our results suggest the following: First, there is no long-run relationship between coal consumption and economic growth in OECD countries; however, in non-OECD countries, the relationship does exist. Second, excessive coal usage may hinder economic growth in the long run. Lastly, the growth hypothesis (coal consumption affects economic growth positively is supported in the short run for non-OECD countries. As coal consumption has a positive effect on economic growth in the short run and a negative effect in the long run, energy conservation policies may have adverse effects only in the short run. Thus, non-OECD countries should gradually switch their energy mix to become less coal-dependent as they consider climate change. Moreover, a transfer of technology and financial resources from developed to developing countries must be encouraged at a global level.

Purchasing power parity in OECD countries: nonlinear unit root tests revisited

OpenAIRE

Juan Carlos Cuestas; Paulo José Regis

2010-01-01

The aim of this paper is to provide additional evidence on the purchasing power parity empirical fulfillment in a pool of OECD countries. We apply the Harvey et al. (2008) linearity test and the Kruse (2010) nonlinear unit root test. The results point to the fact that the purchasing power parity theory holds in a greater number of countries than has been reported in previous studies.

PERAN OECD DALAM MEMINIMALKAN UPAYA TAX AGRESIVENESS PADA PERUSAHAAN MULTINATIONALITY

Directory of Open Access Journals (Sweden)

Hanindia Hajjar Damayanti

2017-04-01

Full Text Available Abstract: OECD's Role in Minimizing Tax Aggressiveness Efforts at Multinationality Companies. This paper aims to prove the relation between multinationality transaction of tax heaven countries and the tax investigation toward the tax aggressiveness. This research is done by quantitative approach upon the companies registered in BEI for 2010-2014 periods. The findings denote the tax heaven countries have no effort to conduct the tax aggressiveness on which the multinationality negatively has no effect since the occurrence in the OECD Transfer Pricing Guidelines as the guideline for both the taxing authority and the multinational companies in accomplishing the transfer pricing matter. In contrary, the investigation does not influence the tax aggressiveness.

5-Fluorouracil, colchicine, benzo[a]pyrene and cytosine arabinoside tested in the in vitro mammalian cell micronucleus test (MNvit) in Chinese hamster V79 cells at Covance Laboratories, Harrogate, UK in support of OECD draft Test Guideline 487.

Science.gov (United States)

Whitwell, James; Fowler, Paul; Allars, Sarah; Jenner, Karen; Lloyd, Melvyn; Wood, Debbie; Smith, Katie; Young, Jamie; Jeffrey, Laura; Kirkland, David

2010-10-29

The reference genotoxic agents 5-fluorouracil (a nucleoside analogue, characterised by a steep dose response profile), colchicine (an aneugen that inhibits tubulin polymerisation), benzo[a]pyrene (a polycyclic aromatic hydrocarbon requiring metabolic activation) and cytosine arabinoside (a nucleoside analogue that inhibits the gap-filling step of excision repair) were tested in the in vitro micronucleus assay using the Chinese hamster V79 cell line at Covance Laboratories, Harrogate, UK. All chemicals were treated in the absence and presence of cytokinesis block (via addition of cytochalasin B) with this work forming part of a collaborative evaluation of the toxicity measures recommended in the draft OECD Test Guideline 487 on the In Vitro Mammalian Cell Micronucleus Test (MNvit). The toxicity measures used, detecting a possible combination of both cytostasis and cell death (though not cell death directly), were relative population doubling, relative increase in cell counts and relative cell counts for treatments in the absence of cytokinesis block, and replication index in the presence of cytokinesis block. All of the chemicals tested either gave marked increases in the percentage of micronucleated cells with and without cytokinesis block, or did not induce micronuclei at concentrations giving approximately 50-60% toxicity (cytostasis and cell death) or less by all of the toxicity measures used. The outcome from this series of tests supports the use of relative increase in cell counts and relative population doubling, as well as relative cell counts, as appropriate measures of cytotoxicity for the non-cytokinesis blocked in vitro micronucleus assay. Copyright © 2010 Elsevier B.V. All rights reserved.

Development and validation of an OECD reproductive toxicity test guideline with the mudsnail Potamopyrgus antipodarum (Mollusca, Gastropoda).

Science.gov (United States)

Ruppert, Katharina; Geiß, Cornelia; Askem, Clare; Benstead, Rachel; Brown, Rebecca; Coke, Maira; Ducrot, Virginie; Egeler, Philipp; Holbech, Henrik; Hutchinson, Thomas H; Kinnberg, Karin L; Lagadic, Laurent; Le Page, Gareth; Macken, Ailbhe; Matthiessen, Peter; Ostermann, Sina; Schimera, Agnes; Schmitt, Claudia; Seeland-Fremer, Anne; Smith, Andy J; Weltje, Lennart; Oehlmann, Jörg

2017-08-01

Mollusks are known to be uniquely sensitive to a number of reproductive toxicants including some vertebrate endocrine disrupting chemicals. However, they have widely been ignored in environmental risk assessment procedures for chemicals. This study describes the validation of the Potamopyrgus antipodarum reproduction test within the OECD Conceptual Framework for Endocrine Disrupters Testing and Assessment. The number of embryos in the brood pouch and adult mortality serve as main endpoints. The experiments are conducted as static systems in beakers filled with artificial medium, which is aerated trough glass pipettes. The test chemical is dispersed into the medium, and adult snails are subsequently introduced into the beakers. After 28 days the reproductive success is determined by opening the brood pouch and embryo counting. This study presents the results of two validation studies of the reproduction test with eleven laboratories and the chemicals tributyltin (TBT) with nominal concentrations ranging from 10 to 1000 ng TBT-Sn/L and cadmium with concentrations from 1.56 to 25 μg/L. The test design could be implemented by all laboratories resulting in comparable effect concentrations for the endpoint number of embryos in the brood pouch. After TBT exposure mean EC 10 , EC 50 , NOEC and LOEC were 35.6, 127, 39.2 and 75.7 ng Sn/L, respectively. Mean effect concentrations in cadmium exposed snails were, respectively, 6.53, 14.2, 6.45 and 12.6 μg/L. The effect concentrations are in good accordance with already published data. Both validation studies show that the reproduction test with P. antipodarum is a well-suited tool to assess reproductive effects of chemicals. Copyright © 2017 Elsevier Ltd. All rights reserved.

The investigation of the national views for the strategic plan 2005-2009 of OECD/NEA

International Nuclear Information System (INIS)

Ko, H. S.; Ryu, J. S.; Lee, K. S.; Yang, M. H.

2004-01-01

OECD/NEA has been developing the Strategic Plan of 2005-2009 which will be used as the guidelines of NEA activities for this period. Korean government is of the view that national interests in the cooperation with OECD/NEA become important and are needed to be reflected to this Strategic Plan. We has prepared and suggested Korean proposal for the Strategic Plan of OECD/NEA

OECD validation study to assess intra- and inter-laboratory reproducibility of the zebrafish embryo toxicity test for acute aquatic toxicity testing

NARCIS (Netherlands)

Busquet, F.; Strecker, R.; Rawlings, J.M.; Belanger, S.E.; Braunbeck, T.; Carr, G.J.; Cenijn, P.H.; Fochtman, P.; Gourmelon, A.; Hübler, N.; Kleensang, A.; Knöbel, M.; Kussatz, C.; Legler, J.; Lillicrap, A.; Martínez-Jerónimo, F.; Polleichtner, C.; Rzodeczko, H.; Salinas, E.; Schneider, K.E.; Scholz, S.; van den Brandhof, E.J.; van der Ven, L.T.; Walter-Rohde, S.; Weigt, S.; Witters, H.; Halder, M.

2014-01-01

A The OECD validation study of the zebrafish embryo acute toxicity test (ZFET) for acute aquatic toxicity testing evaluated the ZFET reproducibility by testing 20 chemicals at 5 different concentrations in 3 independent runs in at least 3 laboratories. Stock solutions and test concentrations were

Catch-up validation study of an in vitro skin irritation test method based on an open source reconstructed epidermis (phase II).

Science.gov (United States)

Groeber, F; Schober, L; Schmid, F F; Traube, A; Kolbus-Hernandez, S; Daton, K; Hoffmann, S; Petersohn, D; Schäfer-Korting, M; Walles, H; Mewes, K R

2016-10-01

To replace the Draize skin irritation assay (OECD guideline 404) several test methods based on reconstructed human epidermis (RHE) have been developed and were adopted in the OECD test guideline 439. However, all validated test methods in the guideline are linked to RHE provided by only three companies. Thus, the availability of these test models is dependent on the commercial interest of the producer. To overcome this limitation and thus to increase the accessibility of in vitro skin irritation testing, an open source reconstructed epidermis (OS-REp) was introduced. To demonstrate the capacity of the OS-REp in regulatory risk assessment, a catch-up validation study was performed. The participating laboratories used in-house generated OS-REp to assess the set of 20 reference substances according to the performance standards amending the OECD test guideline 439. Testing was performed under blinded conditions. The within-laboratory reproducibility of 87% and the inter-laboratory reproducibility of 85% prove a high reliability of irritancy testing using the OS-REp protocol. In addition, the prediction capacity was with an accuracy of 80% comparable to previous published RHE based test protocols. Taken together the results indicate that the OS-REp test method can be used as a standalone alternative skin irritation test replacing the OECD test guideline 404. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

40 CFR 766.12 - Testing guidelines.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Testing guidelines. 766.12 Section 766... DIBENZO-PARA-DIOXINS/DIBENZOFURANS General Provisions § 766.12 Testing guidelines. Analytical test methods must be developed using methods equivalent to those described or reviewed in Guidelines for the...

A Summary of the MARS Analysis Results about OECD/SETH PANDA Tests

International Nuclear Information System (INIS)

Bae, Sung Won; Chung, Bub Dong

2007-01-01

The thermal-hydraulic phenomena in a multicompartment space like the containment building under accidents are very complicated and unpredictable as a result of many interacting processes, such as sprays, hydrogen recombiners, etc. Many thermal-hydraulic phenomena, governing the containment response under postulated accidents, have been identified by the SESAR/CAF (OECD) as 'research needs' for current and advanced LWRs. Due to the recent extension of the numerical computation capability and the technology, the safety analysis field is requested to expand their analysis domain beyond the current primary system. In particular, hydrogen mixing and transport has been found to be of special importance for safety and regulation. Up to dates, OECD/CSNI has been leading many experimental projects, for example, OECD-PKL, ISP47, OECD-PANDA, focusing the gas mixing, stratification and vapor condensation phenomena. As the one of the activities, the OECD-SETH group has launched the PANDA Project in order to provide an experimental data base for a multi-dimensional code assessment in 2002. PANDA is a large scale thermal-hydraulic facility to provide a resolved experimental data base about the gas mixing and stratification phenomena. OECD-SETH group expects the PANDA Project will meet the increasing needs for adequate experimental data for a 3D distribution of relevant variables like the temperature, velocity and steam-air concentrations that are measured with a sufficient resolution and accuracy

2-Aminoanthracene, 5-fluorouracil, colchicine, benzo[a]pyrene, cadmium chloride and cytosine arabinoside tested in the in vitro mammalian cell micronucleus test (MNvit) in Chinese hamster ovary (CHO) cells at Covance Laboratories, Harrogate UK in support of OECD draft Test Guideline 487.

Science.gov (United States)

Whitwell, James; Fowler, Paul; Allars, Sarah; Jenner, Karen; Lloyd, Melvyn; Wood, Debbie; Smith, Katie; Young, Jamie; Jeffrey, Laura; Kirkland, David

2010-10-29

The reference genotoxic agents 2-aminoanthracene (a metabolism dependent weak clastogen), 5-fluorouracil (a nucleoside analogue, characterised by a steep dose response profile), colchicine (an aneugen that inhibits tubulin polymerisation), benzo[a]pyrene (a polycyclic aromatic hydrocarbon requiring metabolic activation), cadmium chloride (an inorganic carcinogen), and cytosine arabinoside (a nucleoside analogue that inhibits the gap-filling step of excision repair) were tested in the in vitro micronucleus assay using the Chinese hamster ovary (CHO) cell line at Covance Laboratories, Harrogate, UK. All chemicals were treated in the absence and presence of cytokinesis block (via addition of cytochalasin B) with this work forming part of a collaborative evaluation of the toxicity measures recommended in the draft OECD Test Guideline 487 on the In vitro Mammalian Cell Micronucleus Test (MNvit). The toxicity measures used, detecting a possible combination of both cytostasis and cell death (though not cell death directly), were relative population doubling, relative increase in cell counts and relative cell counts for treatments in the absence of cytokinesis block, and replication index in the presence of cytokinesis block. All of the chemicals tested either gave marked positive increases in the percentage of micronucleated cells with and without cytokinesis block, or did not induce micronuclei at concentrations giving approximately 50-60% toxicity (cytostasis and cell death) or less by all of the toxicity measures used. The outcome from this series of tests supports the use of relative increase in cell counts and relative population doubling, as well as relative cell counts, as appropriate measures of cytotoxicity for the non-cytokinesis blocked in vitro micronucleus assay. Copyright © 2010 Elsevier B.V. All rights reserved.

OECD Policy Recommendations on Security for Biological Materials

International Nuclear Information System (INIS)

Radisch, J.

2007-01-01

Biomedical innovations derived from research on pathogenic micro-organisms promise astounding health and economic benefits. Some such biological resources employed in the RandD for diagnostic kits, vaccines and therapeutics, however, possess capacity for dual-use; they may be misused to develop biological weapons. Research facilities entrusted with possession of such dual-use materials have a responsibility to comply with biosecurity measures that are designed to prevent loss or theft and thereby reduce the probability of a bioterrorist attack. The OECD has provided a forum for its Member countries to engage in a dialogue of international co-operation with a view to produce policies that achieve a research environment fortified by biosecurity measures and capable of producing health innovations. In 2007, the OECD developed a risk assessment framework and risk management principles for Biological Resource Centres. Ongoing policy work at the OECD will look to design biosecurity guidelines appropriate to a broader range of facilities in possession of dual-use materials, such as university and industrial laboratories.(author)

Influence of test conditions and exposure duration on the result of ecotoxicological tests

DEFF Research Database (Denmark)

Rosenkrantz, Rikke Tjørnhøj

be calculated from results of ecotoxicological tests performed according to internationally approved guidelines, such as from the Organisation for Economic Co-operation and Development (OECD) or International Standardization Organisation (ISO). Such guidelines were originally developed to enable classification......H and exposure duration on the toxicity recorded in tests using four sulfonylurea herbicides (SUs) and the aquatic macrophyte Lemna gibba as study objects. The study showed that changing the physical and chemical test conditions influenced the toxicity of sulfonylurea herbicides towards L. gibba. Lowering...

Development of an alternative testing strategy for the fish early life-stage (FELS) test using the AOP framework

Science.gov (United States)

Currently, the fish early life-stage (FELS) test (OECD 210) is the primary guideline used to estimate chronic toxicity of regulated chemicals. Although already more cost-efficient than adult fish tests, the FELS test has some important drawbacks. Both industry and regulatory inst...

Acute oral toxicity test of chemical compounds in silkworms.

Science.gov (United States)

Usui, Kimihito; Nishida, Satoshi; Sugita, Takuya; Ueki, Takuro; Matsumoto, Yasuhiko; Okumura, Hidenobu; Sekimizu, Kazuhisa

2016-02-01

This study performed an acute oral toxicity test of 59 compounds in silkworms. These compounds are listed in OECD guidelines as standard substances for a cytotoxicity test, and median lethal dose (LD(50)) werecalculated for each compound. Acute oral LD(50) values in mammals are listed in OECD guidelines and acute oral LD(50) values in silkworms were determined in this study. R(2) for the correlation between LD(50) values in mammals and LD(50) values in silkworms was 0.66. In addition, the acute oral toxicity test in silkworms was performed by two different facilities, and test results from the facilities were highly reproducible. These findings suggest that an acute oral toxicity test in silkworms is a useful way to evaluate the toxicity of compounds in mammals.

PACTEL OECD project planning (PACO). PACTEL OECD project planning

Energy Technology Data Exchange (ETDEWEB)

Kouhia, V.; Purhonen, H. [Lappeenranta University of Technology (Finland)

2004-07-01

OECD launched the SETH project to investigate issues relevant for accident prevention and management and to ensure the existence of integral thermal hydraulic test facilities. The facilities included in the SETH project are PKL from Germany and PANDA from Switzerland. At the early stages of the SETH project an idea was raised to exploit the PACTEL facility in a similar OECD project. Without any external funding the analytical work in the required extent would not be possible within Lappeenranta University of Technology, the party responsible of operating PACTEL. This fact directed the PACO project proposal to be conducted for the SAFIR programme. The aim of the PACO project is to prepare a project proposal to OECD of a PACTEL related project. To attain this objective some preliminary analyses have to be performed to ensure the relevancy of the proposed topic. The low power situation, i.e. midloop state was chosen to be the topic in the PACO studies and project planning basis. The plan is to use PACTEL to examine vertical steam generator behaviour during the midloop operation and the following loss of residual heat removal system transient. Such a possibility is acknowledged with special alterations to PACTEL. The APROS code version 5.04.07 was selected as a tool for the preanalyses. The virtual simulation of the chosen experimental situation would give a preconception on the phenomena to be expected and the progression of the transient. Originally the PACO project was planned to continue only for a few months, ending up with the project proposal to OECD during the summer time 2004. During the pre-calculation process it became obvious that the time expected was not enough to establish good pre-calculation results. The reasons for this relates to time used to learn and adapt the use of the chosen code, improvements and corrections in modelling as well as the code ability to manage the special conditions defined for the project topic. Another aspect on completing a

LOFT/LP-02-6, Loss of Fluid Test, 1. OECD Large Break Experiment

International Nuclear Information System (INIS)

1989-01-01

1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCA is expected to closely model a LPWR LOCA. 2 - Description of test: The fourth OECD LOFT experiment was conducted on 3 October 1983. This was the first OECD LOFT large break experiment. The initial and boundary conditions were chosen to be representative of USNRC licensing limits for commercial PWRs. This included loss of off-site power coincident with LOCA initiation. This experiment included the first use in LOFT of pressurized fuel rods in the center bundle. The experiment was initiated by opening the quick-opening blow-down valves in the broken hot and cold legs. 3 - Experimental limitations or shortcomings: Short core and steam generator, excessive core bypass, other scaling compromises, and lack of adequate measurements in certain areas

A Critical Analysis of the Environmental Dossiers from the OECD Sponsorship Programme for the Testing of Manufactured Nanomaterials

DEFF Research Database (Denmark)

Hansen, Steffen Foss; Hjorth, Rune; Skjolding, Lars Michael

2017-01-01

In 2015, the OECD finally published the findings of its seven year testing programme for manufactured nanomaterials. Here, we present the first in-depth analysis of the published OECD dossiers with regards to data on physical and chemical properties, environmental fate and ecotoxicology. Each...... prior, during and/or at the end of the study. We find that the information in the dossiers present an incomplete portfolio of nanomaterial ecotoxicological evaluations that are difficult to draw substantive conclusions from and that most of the studies were not designed to investigate the validity...

Draft Test Guideline: Aquatic Food Chain Transfer

Science.gov (United States)

The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review.

Testing the effect of defaults on the thermostat settings of OECD employees

International Nuclear Information System (INIS)

Brown, Zachary; Johnstone, Nick; Haščič, Ivan; Vong, Laura; Barascud, Francis

2013-01-01

We describe a randomized controlled experiment in which the default settings on office thermostats in an OECD office building were manipulated during the winter heating season, and employees' chosen thermostat setting observed over a 6-week period. Using difference-in-differences, panel, and censored regression models (to control for maximum allowable thermostat settings), we find that a 1 °C decrease in the default caused a reduction in the chosen setting by 0.38 °C, on average. Sixty-five percent of this effect could be attributed to office occupant behavior (p-value = 0.044). The difference-in-differences models show that small decreases in the default (1°) led to a greater reduction in chosen settings than large decreases (2°). We also find that office occupants who were more apt to adjust their thermostats prior to the intervention were less susceptible to the default. We conclude that this kind of intervention can increase building-level energy efficiency, and discuss potential explanations and broader policy implications of our findings. - Highlights: • We conduct a randomized controlled trial to test if thermostat defaults affect agent behavior. • Two treatments (schedules of default settings) were tested against a control for 6 weeks at OECD. • Small changes in defaults had a greater effect on chosen settings than larger changes in defaults. • Occupants who frequently changed their thermostats in baseline were less affected by defaults. • Thermostat defaults in office environments can be manipulated to increase energy efficiency

Guidelines for testing sealed radiation sources

International Nuclear Information System (INIS)

1989-01-01

These guidelines are based on article 16(1) of the Ordinance on the Implementation of Atomic Safety and Radiation Protection dated 11 October 1984 (VOAS), in connection with article 36 of the Executory Provision to the VOAS, of 11 October 1984. They apply to the testing of sealed sources to verify their intactness, tightness and non-contamination as well as observance of their fixed service time. The type, scope and intervals of testing as well as the evaluation of test results are determined. These guidelines also apply to the testing of radiation sources forming part of radiation equipment, unless otherwise provided for in the type license or permit. These guidelines enter into force on 1 January 1990

Toxicity testing with the collembolans Folsomia fimetaria and Folsomia candida and the results of a ringtest

DEFF Research Database (Denmark)

Krogh, Paul Henning

A ringtest was performed to introduce collembolans for the OECD test guideline programme. One species, the parthenogenetic Folsomia candida, is already an approved ISO standard while the sexually reproducing Folsomia fimetaria is introduced in the draft test guideline as an alternative to F. cand...

Renewable energy and macroeconomic efficiency of OECD and non-OECD economies

International Nuclear Information System (INIS)

Chien, Taichen; Hu, Jin-Li

2007-01-01

This article analyzes the effects of renewable energy on the technical efficiency of 45 economies during the 2001-2002 period through data envelopment analysis (DEA). In our DEA model, labor, capital stock, and energy consumption are the three inputs and real GDP is the single output. Increasing the use of renewable energy improves an economy's technical efficiency. Conversely, increasing the input of traditional energy decreases technical efficiency. Compared to non-OECD economies, OECD economies have higher technical efficiency and a higher share of geothermal, solar, tide, and wind fuels in renewable energy. However, non-OECD economies have a higher share of renewable energy in their total energy supply than OECD economies

European guidelines for workplace drug testing in urine.

Science.gov (United States)

Taskinen, Sanna; Beck, Olof; Bosch, Tessa; Brcak, Michaela; Carmichael, Duncan; Fucci, Nadia; George, Claire; Piper, Mark; Salomone, Alberto; Schielen, Wim; Steinmeyer, Stefan; Weinmann, Wolfgang

2017-06-01

These European Guidelines for Workplace Drug Testing in Urine have been prepared and updated by the European Workplace Drug Testing Society (EWDTS). The first version of these urine guidelines was published in 2002. Since then, the guidelines have been followed by many laboratories in different European countries and their role has been essential particularly in countries lacking legislation for workplace drug testing. In 2014, the EWDTS started a guidelines updating project and published a new version of the urine guidelines in 2015. Here we represent this updated version of the urine guidelines. The European Guidelines are designed to establish best practice procedures whilst allowing individual countries to operate within the requirements of national customs and legislation. The EWDTS recommends that all European laboratories that undertake legally defensible workplace drug testing should use these guidelines as a template for accreditation. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

OECD/NEA thermochemical database

Energy Technology Data Exchange (ETDEWEB)

Byeon, Kee Hoh; Song, Dae Yong; Shin, Hyun Kyoo; Park, Seong Won; Ro, Seung Gy

1998-03-01

This state of the art report is to introduce the contents of the Chemical Data-Service, OECD/NEA, and the results of survey by OECD/NEA for the thermodynamic and kinetic database currently in use. It is also to summarize the results of Thermochemical Database Projects of OECD/NEA. This report will be a guide book for the researchers easily to get the validate thermodynamic and kinetic data of all substances from the available OECD/NEA database. (author). 75 refs.

Animal Testing for Acute Inhalation Toxicity: A Thing of the Past?

DEFF Research Database (Denmark)

Da Silva, Emilie; Sørli, Jorid Birkelund

2018-01-01

According to REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals), testing for acute inhalation toxicity is required for chemicals manufactured or imported at tonnages ≥ 10 tons per year. Three OECD test guidelines for acute inhalation toxicity in vivo are adopted (TG 403......, TG 436, and TG 433). Since animal testing is ethically, scientifically and economically questionable, adoption of alternative methods by the European Union and the OECD is needed. An in vitro system based on the study of lung surfactant function is introduced....

RELAP5/MOD2 calculation of OECD LOFT test LP-FW-01

International Nuclear Information System (INIS)

Croxfod, M.G.; Harwood, C.; Hall, P.C.

1992-04-01

RELAP5/MOD2 is being used by GDCD for calculation of certain small break loss-of-coolant accidents and pressurized transients in the Sizewell ''B'' PWR. To test the ability of RELAP5/MOD2 to model the primary feed-and-bleed recovery procedure following a complete loss- of-feedwater event, post test calculations have been carried out of OECD LOFT test LP-FW-01. This report describes the comparison between the code calculations and the test data. It is found that although the standard version of RELAP5/MOD2 gives a reasonable prediction of the experimental transient, the long term pressure history is better calculated with a modified code version containing a revised horizontal stratification entrainment model. The latter allows an improved calculation of entrainment of liquid from the hot leg into the surge line. RELAP5/MOD2 is found to give a more accurate simulation of the experimental transient than was achieved in previous UK studies using RETRAN-02/MOD2

The OECD validation program of the H295R steroidogenesis assay: Phase 3. Final inter-laboratory validation study

DEFF Research Database (Denmark)

Hecker, Markus; Hollert, Henner; Cooper, Ralph

2011-01-01

In response to increasing concerns regarding the potential of chemicals to interact with the endocrine system of humans and wildlife, various national and international programs have been initiated with the aim to develop new guidelines for the screening and testing of these chemicals in vertebra......In response to increasing concerns regarding the potential of chemicals to interact with the endocrine system of humans and wildlife, various national and international programs have been initiated with the aim to develop new guidelines for the screening and testing of these chemicals...... in vertebrates. Here, we report on the validation of an in vitro assay, the H295R steroidogenesis assay, to detect chemicals with the potential to inhibit or induce the production of the sex steroid hormones testosterone (T) and 17β-estradiol (E2) in preparation for the development of an Organization...... for Economic Cooperation and Development (OECD) test guideline.A previously optimized and pre-validated protocol was used to assess the potential of 28 chemicals of diverse structures and properties to validate the H295R steroidogenesis assay. These chemicals are comprised of known endocrine-active chemicals...

The Reasonableness Test of the Principal Purpose Test Rule in OECD BEPS Action 6 (Tax Treaty Abuse) versus the EU Principle of Legal Certainty and the EU Abuse of Law Case Law

NARCIS (Netherlands)

D. Weber (Dennis)

2017-01-01

textabstractThe OECD BEPS Action 6 report contains a principal pur- pose test rule (PPT rule) for the purpose of combating abuse of tax treaties. This PPT rule is also included in the OECD Multilateral Instrument. The PPT rule is (amongst others) applicable when ‘it is rea- sonable to conclude’

An overview of the fuels and materials testing programme at the OECD Halden Reactor Project

Energy Technology Data Exchange (ETDEWEB)

Wiesenack, W [Institutt for Energiteknikk, Halden (Norway). OECD Halden Reaktor Projekt

1997-08-01

The fuels and materials testing programme of the OECD Halden Reactor Project is aimed at investigations of fuel and cladding properties at high burnup, water chemistry effects and in-core materials ageing problems. For the execution of this programme, different types of irradiation rigs and experimental facilities providing typical power reactors conditions are available. Data are obtained from in-core sensors developed at the Halden Project; these are shortly described. An overview of the current test programme and the scope of the following years are briefly presented. (author). 5 refs, 3 figs.

Overview of fuel testing capabilities at the OECD Halden reactor project

Energy Technology Data Exchange (ETDEWEB)

Wiesenack, W [Institutt for Atomenergi, Halden (Norway). OECD Halden Reaktor Projekt

1994-12-31

Fuel performance and reliability investigations at the OECD Haiden Reactor Project are described. They are supported by a variety of irradiation rigs, suitable irradiation techniques and a range of instrumentation. Testing capabilities and applications are mainly aimed at exploring mechanisms of fuel behaviour and high burnup. Examples of fuel performance taken from data provided by the Halden Project for the IAEA Co-ordinated Research Programme FUMEX are presented. A number of heavily instrumented rigs to suit different test objects have been developed: base irradiation rig, gas meter rig, diameter measurement rig, ramp rig, gas flow rig, instrumented fuel assembly. In core-measurements and variety of sensors as : fuel thermocouples, bellows pressure transducers, fuel stack elongation detectors, cladding diameter gauge and cladding elongation detectors have been used. Techniques which make it possible to obtain reliable data for all relevant burnups from beginning-of-life to ultra high exposure reaching 100 Mwd/kg UO{sub 2} are described. 7 figs., 3 refs.

The Reasonableness Test of the Principal Purpose Test Rule in OECD BEPS Action 6 (Tax Treaty Abuse) versus the EU Principle of Legal Certainty and the EU Abuse of Law Case Law

OpenAIRE

Weber, Dennis

2017-01-01

textabstractThe OECD BEPS Action 6 report contains a principal pur- pose test rule (PPT rule) for the purpose of combating abuse of tax treaties. This PPT rule is also included in the OECD Multilateral Instrument. The PPT rule is (amongst others) applicable when ‘it is rea- sonable to conclude’ that a benefit (granted by a tax treaty) was one of the principal purposes of any arrangement/ transaction. This requirement contains two elements: the reasonableness test and the principal purpose tes...

The OECD FIRE database

International Nuclear Information System (INIS)

Angner, A.; Berg, H.P.; Roewekamp, M.; Werner, W.; Gauvain, J.

2007-01-01

Realistic modelling of fire scenarios is still difficult due to the scarcity of reliable data needed for deterministic and probabilistic fire safety analysis. Therefore, it has been recognized as highly important to establish a fire event database on an international level. In consequence, several member countries of the Nuclear Energy Agency of the OECD have decided in 2000 to establish the International Fire Data Exchange Project (OECD FIRE) to encourage multilateral co-operation in the collection and analysis of data related to fire events at nuclear power plants. This paper presents the OECD FIRE project objectives, work scope and current status of the OECD FIRE database after 3 years of operation as well as first preliminary statistical insights gained from the collected data. (orig.)

Impact, regulation and health policy implications of physician migration in OECD countries

Directory of Open Access Journals (Sweden)

Simoens Steven

2004-07-01

Full Text Available Abstract Background In the face of rising demand for medical services due to ageing populations, physician migration flows are increasingly affecting the supply of physicians in Organisation for Economic Co-operation and development (OECD countries. This paper offers an integrated perspective on the impact of physician migration on home and host countries and discusses international regulation and policy approaches governing physician migration. Methods Information about migration flows, international regulation and policies governing physician migration were derived from two questionnaires sent to OECD countries, a secondary analysis of EUROSTAT Labour Force Surveys, a literature review and official policy documents of OECD countries. Results OECD countries increasingly perceive immigration of foreign physicians as a way of sustaining their physician workforce. As a result, countries have entered into international agreements regulating physician migration, although their success has been limited due to the imposition of licensing requirements and the protection of vested interests by domestic physicians. OECD countries have therefore adopted specific policies designed to stimulate the immigration of foreign physicians, whilst minimising its negative impact on the home country. Measures promoting immigration have included international recruitment campaigns, less strict immigration requirements and arrangements that foster shared learning between health care systems. Policies restricting the societal costs of physician emigration from developing countries such as good practice guidelines and taxes on host countries have not yet produced their expected effect or in some cases have not been established at all. Conclusions Although OECD countries generally favour long-term policies of national self-sufficiency to sustain their physician workforce, such policies usually co-exist with short-term or medium-term policies to attract foreign physicians

Estonia to join OECD / Ella Karapetyan

Index Scriptorium Estoniae

Karapetyan, Ella

2010-01-01

2010. aasta kevadel tehakse otsus Eesti liitumise kohta OECD-ga. Välisminister Urmas Paet ja OECD peasekretär Angel Gurria allkirjastasid Pariisis privileegide ja immuniteetide lepingu. OECD liikmed

FDS5 Simulation for OECD PRISME Fire Test of DOOR PRSD5

International Nuclear Information System (INIS)

Lee, Kyu Bok; Park, Jong Seuk

2009-01-01

OECD/NEA PRISME Fire Project is an international co-operation project to investigate fire propagation by means of experiments and analyses for nuclear power plant applications. This project focuses on the generation of experimental data for fire and smoke propagation from the fire room to adjacent rooms under various conditions and room configurations. In addition, analyses using computer codes are performed to understand the phenomena of interest and to produce a consistent interpretation of the experimental results. The PRISME Project is composed of series of tests named as SOURCE, DOOR, LEAK and Global Tests. The SOURCE is composed of tests to characterize the fire source, and the DOOR is to study fire and smoke propagation through an open door, while the LEAK is to investigate hot gas leakages through other modes of openings such as holes, a slot, a duct, and a partially opened door. The Global test will be conducted as integral tests on the basis of the results of the previous separate effects tests. In this paper, simulations are performed with FDS5 computer code for the DOOR Test No.5 (PRS D 5) and the calculation results are compared with the corresponding experimental data to study the code capability to predict the phenomena of the hot gas propagation between two rooms

Eesti loodab peagi OECD liikmekutset / Sirje Rank

Index Scriptorium Estoniae

Rank, Sirje, 1966-

2010-01-01

OECD on Eesti hindamisel jõudnud lõppjärku, liitumiskutset on oodata maikuus. OECD-le pakub huvi Eesti reformikogemus, e-valitsusega seonduv, oodatud on Eesti seisukohad OECD liitumiskõnelustel Venemaaga. OECD tegevusest

State of Art Report for the OECD-NEA Loss-of-Forced Cooling (LOFC) Test Project using HTTR Reactor

International Nuclear Information System (INIS)

Jun, Ji Su

2011-05-01

The OECD/NEA Project is planned to perform the LOFC (Loss Of Forced Cooling) test using the HTTR (High Temperature engineering Test Reactor) in Japan from 31 March 2011 to 31 March 2013 in order to obtain the data for the code validation of the VHTR safety analysis. Based on the Project Agreement Document, this report gives a description of the HTTR-LOFC test, HTTR test facility, project schedule and deliverable items as the technical state art of the project, and appends the full translation of the project agreement articles on the project management

Guidance Document on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption

DEFF Research Database (Denmark)

Satya, Sneha; Wade, Mike; Hass, Ulla

This guidance document was developed as a follow-up to the workshop on OECD countries’ activities regarding testing, assessment and management of endocrine disrupters, which was held in Copenhagen (Denmark) on 22-24 September 2010 (see document No. 118 published in the Series on Testing and Asses......This guidance document was developed as a follow-up to the workshop on OECD countries’ activities regarding testing, assessment and management of endocrine disrupters, which was held in Copenhagen (Denmark) on 22-24 September 2010 (see document No. 118 published in the Series on Testing...... on testing and assessment of endocrine disrupters (EDTA AG). In November 2010, comments were requested from the WNT, the EDTA AG, the Task Force on Hazard Assessment and experts involved in the assessment of chemicals. The EDTA AG addressed the comments from the WNT at a meeting held in April 2011...... the conclusions and next steps recommended in the draft guidance document are sensible and helpful when assessed in light of comprehensive datasets. The draft guidance document and the three case studies were reviewed again and revised at a meeting of the EDTA AG in December 2011. The draft guidance document...

OECD:s multilaterala BEPS-konvention – Ärdubbelbeskattning tillbaka på menyn?OECD:s multilateral BEPS-convention – Is double Taxation back on the menu?

OpenAIRE

Bender, Lars-Ole

2017-01-01

Uppsatsen behandlar OECD:s multilaterala BEPS-konvention för vilken i skrivande stund OECD om några dagar ska hålla en signeringscermoni. Uppsatsen innefattar en redogörelse för bakomliggande traktatsrätt, en redogörelse för konventionen i sig samt hänvisningar till relevant nationell rätt där denna är aktuell för konveentionens tillämpning.

International double (non-)taxation : comparative guidelines from European legal principles

OpenAIRE

Vijver, Van de, Anne

2015-01-01

Abstract: The principle of fairness advocates against international double taxation and international double non-taxation. Countries and international organizations (OECD, G20 and EU) have taken several initiatives against such taxation. However, these initiatives are not always effective. Also, certain legal authors question the legitimacy of the OECD and its action plan on BEPS. The essential goal of this research is to find guidelines to address international double (non-) taxation. We fir...

Experimental Results of OECD-ATLAS A3.1 Test

Energy Technology Data Exchange (ETDEWEB)

Lee, Seung Wook; Kang, Kyung Ho; Bae, Byoung Uhn; Park, Yu Sun; Choi, Nam Hyun; Kim, Kyung Doo; Choi, Ki Yong [KAERI, Daejeon (Korea, Republic of)

2016-05-15

After the Fukushima accident, design extension conditions (DECs) such as a station black-out (SBO) and a TLOFW attracted a wide international attention in a sense that such high-risk multiple failure accidents should be revisited from a viewpoint of the reinforcement of the 'defense in depth' concept. In particular, a TLOFW event has been considered as one of the typical beyond design basis accident (bDBA) in a safety analysis of the pressurized water reactors. From a conservative point of view, however, failure of the active safety components needs to be considered in the safety analysis. During a TLOFW accident the most effective safety-related active components are the safety injection pumps (SIPs) and the pilot-operated safety relief valves (POSRVs) which are used in a feed and bleed operation. OECD-ATLAS A3.1 test was performed to simulate a TLOFW with additional failures such as partial failure of the SIPs and POSRVs. This test was performed with two temporal phases with an aim of investigating the effect of feed and bleed operation as an accident mitigation measure. Major findings of the A3.1 test are summarized as follows: - Following the termination of the feedwater supply, the SGs became dried out due to the cyclic opening and closing of the MSSVs. However, the coolant discharge from the secondary side of steam generators through MSSVs resulted in removing the decay heat and establishing the natural circulation in the primary system. - A large coolant inventory loss of the primary system through the POSRV during a feed and bleed operation resulted in a reduction of the core collapsed level but the minimum core level was still above the top of the active core. As a result, the excursion of the maximum PCT was not observed.

Which points deserve special attention in the new guidelines on X-ray use (testing guidelines for experts and quality assurance guidelines)?

International Nuclear Information System (INIS)

Ewen, K.; Lauber, I.

2004-01-01

Two important guidelines for the application of X-rays in medicine became effective on 1 October 2003 and 1 December 2003. These are testing guidelines for experts and quality assurance guidelines. Both guidelines are very extensive and not always easy to interpret. In the present paper the authors try to explain in detail some chapters important for radiology and to make the necessary technical background transparent. Both authors took an essential part in forming the guidelines. (orig.) [de

Synthesis of the turbulent mixing in a rod bundle with vaned spacer grids based on the OECD-KAERI CFD benchmark exercise

International Nuclear Information System (INIS)

Lee, Jae Ryong; Kim, Jungwoo; Song, Chul-Hwa

2014-01-01

Highlights: • OECD/KAERI international CFD benchmark exercise was operated by KAERI. • The purpose is to validate relevant CFD codes based on the MATiS-H experiments. • Blind calculation results were synthesized in terms of mean velocity and RMS. • Quality of control volume rather than the number of it was emphasized. • Major findings were followed OECD/NEA CSNI report. - Abstract: The second international CFD benchmark exercise on turbulent mixing in a rod bundle has been launched by OECD/NEA, to validate relevant CFD (Computational Fluid Dynamics) codes and develop problem-specific Best Practice Guidelines (BPG) based on the KAERI (Korea Atomic Energy Research Institute) MATiS-H experiments on the turbulent mixing in a 5 × 5 rod array having two different types of vaned spacer grids: split and swirl types. For this 2nd international benchmark exercise (IBE-2), the MATiS-H testing provided a unique set of experimental data such as axial and lateral velocity components, turbulent intensity, and vorticity information. Blind CFD calculation results were submitted by twenty-five (25) participants to KAERI, who is the host organization of the IBE-2, and then analyzed and synthesized by comparing them with the MATiS-H data. Based on the synthesis of the results from both the experiments and blind CFD calculations for the IBE-2, and also by comparing with the IBE-1 benchmark exercise on the mixing in a T-junction, useful information for simulating this kind of complicated physical problem in a rod bundle was obtained. And some additional Best Practice Guidelines (BPG) are newly proposed. A summary of the synthesis results obtained in the IBE-2 is presented in this paper

Synthesis of the turbulent mixing in a rod bundle with vaned spacer grids based on the OECD-KAERI CFD benchmark exercise

Energy Technology Data Exchange (ETDEWEB)

Lee, Jae Ryong; Kim, Jungwoo; Song, Chul-Hwa, E-mail: chsong@kaeri.re.kr

2014-11-15

Highlights: • OECD/KAERI international CFD benchmark exercise was operated by KAERI. • The purpose is to validate relevant CFD codes based on the MATiS-H experiments. • Blind calculation results were synthesized in terms of mean velocity and RMS. • Quality of control volume rather than the number of it was emphasized. • Major findings were followed OECD/NEA CSNI report. - Abstract: The second international CFD benchmark exercise on turbulent mixing in a rod bundle has been launched by OECD/NEA, to validate relevant CFD (Computational Fluid Dynamics) codes and develop problem-specific Best Practice Guidelines (BPG) based on the KAERI (Korea Atomic Energy Research Institute) MATiS-H experiments on the turbulent mixing in a 5 × 5 rod array having two different types of vaned spacer grids: split and swirl types. For this 2nd international benchmark exercise (IBE-2), the MATiS-H testing provided a unique set of experimental data such as axial and lateral velocity components, turbulent intensity, and vorticity information. Blind CFD calculation results were submitted by twenty-five (25) participants to KAERI, who is the host organization of the IBE-2, and then analyzed and synthesized by comparing them with the MATiS-H data. Based on the synthesis of the results from both the experiments and blind CFD calculations for the IBE-2, and also by comparing with the IBE-1 benchmark exercise on the mixing in a T-junction, useful information for simulating this kind of complicated physical problem in a rod bundle was obtained. And some additional Best Practice Guidelines (BPG) are newly proposed. A summary of the synthesis results obtained in the IBE-2 is presented in this paper.

Have Public Finances in the OECD Area Been Sustainable?

Directory of Open Access Journals (Sweden)

Ferraz Ricardo

2018-03-01

Full Text Available The aim of this article is to test, from an empirical standpoint, the existence of sustainable public finances in the Organisation for Economic Co-operation and Development (OECD area as a whole, over the most recent period of the world economy, 1973-2016. The research methods include not only standard stationarity tests, but also tests, which allow for a structural break. The relevant results of this research are a stationary public budget balance expressed as a percentage of GDP and a debt to GDP ratio that is stationary in first differences. According to the literature, this means that a “necessary and sufficient” condition is fulfilled for proving the existence of a strong sustainability. We hope this research can make a valuable contribution to the debate regarding public finances in the world economy. To obtain other relevant conclusions, additional tests will need to be performed in the future in order to assess which members are contributing to the fiscal sustainability of the OECD aggregate.

ITC Guidelines on Quality Control in Scoring, Test Analysis, and Reporting of Test Scores

Science.gov (United States)

Allalouf, Avi

2014-01-01

The Quality Control (QC) Guidelines are intended to increase the efficiency, precision, and accuracy of the scoring, analysis, and reporting process of testing. The QC Guidelines focus on large-scale testing operations where multiple forms of tests are created for use on set dates. However, they may also be used for a wide variety of other testing…

Electricity consumption-real GDP causality nexus: Evidence from a bootstrapped causality test for 30 OECD countries

International Nuclear Information System (INIS)

Narayan, Paresh Kumar; Prasad, Arti

2008-01-01

The goal of this paper is to examine any causal effects between electricity consumption and real GDP for 30 OECD countries. We use a bootstrapped causality testing approach and unravel evidence in favour of electricity consumption causing real GDP in Australia, Iceland, Italy, the Slovak Republic, the Czech Republic, Korea, Portugal, and the UK. The implication is that electricity conservation policies will negatively impact real GDP in these countries. However, for the rest of the 22 countries our findings suggest that electricity conversation policies will not affect real GDP

Reserve requirement systems in OECD countries

OpenAIRE

Yueh-Yun C. O’Brien

2007-01-01

This paper compares the reserve requirements of OECD countries. Reserve requirements are the minimum percentages or amounts of liabilities that depository institutions are required to keep in cash or as deposits with their central banks. To facilitate monetary policy implementation, twenty-four of the thirty OECD countries impose reserve requirements to influence their banking systems’ demand for liquidity. These include twelve OECD countries that are also members of the European Economic and...

Guideline for penetrant testing on welds by indirect visual test

International Nuclear Information System (INIS)

Tanaka, Isao; Taguchi, Tetsuo; Asano, Toshio; Sakai, Kaoru; Sato, Takemitsu; Takagi, Mikio

1999-01-01

A study of guidelines for penetrant testing on welds by indirect visual test using image processing is presented. Due to penetrant testing regulations by direct visual test, a porosity (a round defect) whose diameter is under 1.0 mm is allowed, but no crack (a line-shaped defect) is allowed, and the allowable defect size is not clear. It was found in the investigation that the smallest line-shaped indication which the inspectors could recognize was 0.15 mm in width and 0.5 mm in length. This means that the limit of line pair which all inspectors could discriminate was 3.3. A TV camera was used to take pictures of the NSIT (National Institute of Standards and Technology) (NBS: National Bureau of Standard) resolution chart and the smallest indication above, and the limit of line pair which all inspectors could discriminate was 3.6. Therefore, it is recommended as a guideline for penetrant testing through a TV camera by indirect visual test that the resolution of 3.6 line pair per mm is required and a reference test piece be defined to assure the resolution. (author)

Guideline for penetrant testing on welds by indirect visual test

Energy Technology Data Exchange (ETDEWEB)

Tanaka, Isao; Taguchi, Tetsuo [Hitachi Ltd., Ibaraki (Japan). Hitachi Works; Asano, Toshio; Sakai, Kaoru; Sato, Takemitsu; Takagi, Mikio

1999-07-01

A study of guidelines for penetrant testing on welds by indirect visual test using image processing is presented. Due to penetrant testing regulations by direct visual test, a porosity (a round defect) whose diameter is under 1.0 mm is allowed, but no crack (a line-shaped defect) is allowed, and the allowable defect size is not clear. It was found in the investigation that the smallest line-shaped indication which the inspectors could recognize was 0.15 mm in width and 0.5 mm in length. This means that the limit of line pair which all inspectors could discriminate was 3.3. A TV camera was used to take pictures of the NSIT (National Institute of Standards and Technology) (NBS: National Bureau of Standard) resolution chart and the smallest indication above, and the limit of line pair which all inspectors could discriminate was 3.6. Therefore, it is recommended as a guideline for penetrant testing through a TV camera by indirect visual test that the resolution of 3.6 line pair per mm is required and a reference test piece be defined to assure the resolution. (author)

Investigating Alternatives to the Fish Early Life-Stage Test: A Strategy for Discovering and Annotating Adverse Outcome Pathways for Early Fish Development

Science.gov (United States)

The fish early life-stage (FELS) test (OECD Test Guideline 210) is the primary test used internationally to estimate chronic fish toxicity in support of ecological risk assessments and chemical management programs. As part of an on-going effort to develop efficient and cost-effec...

Alternatives to the Fish Early Life-Stage Test: A Research Strategy for Discovering and Annotating Adverse Outcome Pathways During Fish Development

Science.gov (United States)

The OECD 210 fish early life]stage (FELS) test is the primary guideline test used to estimate chronic fish toxicity, as well as support ecological risk assessments and chemical management programs around the world. As a step toward developing alternatives to the FELS test, a HES...

The value and limitations of rechallenge in the guinea pig maximization test

DEFF Research Database (Denmark)

Frankild, S; Basketter, D A; Andersen, Klaus Ejner

1996-01-01

The guinea pig maximization test (GPMT) has played a primary rôle in the evaluation of potential skin contact sensitizers for 25 years. In the OECD Guideline 406 from 1993, it is specifically suggested that equivocal results from the initial challenge in the GPMT should be evaluated further...

Is the OECD acute worm toxicity test environmentally relevant? The effect of mineral form on calculated lead toxicity

International Nuclear Information System (INIS)

Davies, N.A.Nicola A.; Hodson, M.E.Mark E.; Black, S.Stuart

2003-01-01

The current OECD acute worm toxicity test does not relate well to ambient conditions. - In a series of experiments the toxicity of lead to worms in soil was determined following the draft OECD earthworm reproduction toxicity protocol except that lead was added as solid lead nitrate, carbonate and sulphide rather than as lead nitrate solution as would normally be the case. The compounds were added to the test soil to give lead concentrations of 625-12500 μg Pb g -1 of soil. Calculated toxicities of the lead decreased in the order nitrate>carbonate>sulphide, the same order as the decrease in the solubility of the metal compounds used. The 7-day LC 50 (lethal concentration when 50% of the population is killed) for the nitrate was 5321±275 μg Pb g -1 of soil and this did not change with time. The LC 50 values for carbonate and sulphide could not be determined at the concentration ranges used. The only parameter sensitive enough to distinguish the toxicities of the three compounds was cocoon (egg) production. The EC 50 s for cocoon production (the concentration to produce a 50% reduction in cocoon production) were 993, 8604 and 10246 μg Pb g -1 of soil for lead nitrate, carbonate and sulphide, respectively. Standard toxicity tests need to take into account the form in which the contaminant is present in the soil to be of environmental relevance

Optimizing the design of a reproduction toxicity test with the pond snail Lymnaea stagnalis.

Science.gov (United States)

Charles, Sandrine; Ducrot, Virginie; Azam, Didier; Benstead, Rachel; Brettschneider, Denise; De Schamphelaere, Karel; Filipe Goncalves, Sandra; Green, John W; Holbech, Henrik; Hutchinson, Thomas H; Faber, Daniel; Laranjeiro, Filipe; Matthiessen, Peter; Norrgren, Leif; Oehlmann, Jörg; Reategui-Zirena, Evelyn; Seeland-Fremer, Anne; Teigeler, Matthias; Thome, Jean-Pierre; Tobor Kaplon, Marysia; Weltje, Lennart; Lagadic, Laurent

2016-11-01

This paper presents the results from two ring-tests addressing the feasibility, robustness and reproducibility of a reproduction toxicity test with the freshwater gastropod Lymnaea stagnalis (RENILYS strain). Sixteen laboratories (from inexperienced to expert laboratories in mollusc testing) from nine countries participated in these ring-tests. Survival and reproduction were evaluated in L. stagnalis exposed to cadmium, tributyltin, prochloraz and trenbolone according to an OECD draft Test Guideline. In total, 49 datasets were analysed to assess the practicability of the proposed experimental protocol, and to estimate the between-laboratory reproducibility of toxicity endpoint values. The statistical analysis of count data (number of clutches or eggs per individual-day) leading to ECx estimation was specifically developed and automated through a free web-interface. Based on a complementary statistical analysis, the optimal test duration was established and the most sensitive and cost-effective reproduction toxicity endpoint was identified, to be used as the core endpoint. This validation process and the resulting optimized protocol were used to consolidate the OECD Test Guideline for the evaluation of reproductive effects of chemicals in L. stagnalis. Copyright © 2016 Elsevier Inc. All rights reserved.

Energy balances of OECD countries 1970/1982

International Nuclear Information System (INIS)

Anon.

1984-01-01

The present volume provides standardized energy balance sheets expressed in a common unit of tons of oil equivalent for all OECD Countries. It covers the years 1970 to 1982 year by year and includes many revisions and additions to data previously published. The balances in the present volume are based on data published in OECD Energy Statistics 1971-1981 and OECD Energy Statistics 1981-1982. Tables for each OECD Country include production, import, export, consumption by the different industries, transportation, agriculture, residential sector of the different energies: solid fuels, petroleum, gas, nuclear power and hydroelectricity [fr

OECD Halden Reactor Project

International Nuclear Information System (INIS)

1983-01-01

The OECD Halden Reactor Project is both the oldest and the only one still in operation of the three major joint undertakings established at the inception of the OECD Nuclear Energy Agency. This publication has been printed in connection with its twenty-fifth anniversary as an international project. After presentation of the history and organization of the project, a thorough description of the past and present activities in the field of fuel performance and process control and surveillance is given. The projects's fuel testing programme is now focuessed on an investigation to define safety margins under normal operations as well as under various kinds of accident situations. Fuel research is also concerned with the characterisation of long term effects with regard to efficiency, operational safety and mapping of reliability and durability in the case of accidents with loss of coolant. In the field of process control and surveillance, research work is directly linked to the use of computers and colour graphics as tools in the control room. A fullscale simulator-based model and experimental control room has been constructed. The first experiments to be carried out in this laboratory will investigate the advantage of analysing alarms before they are presented to the operator. (RF)

Broadband and Unbundling Regulations in OECD Countries

OpenAIRE

Wallsten, Scott

2006-01-01

Broadband penetration and available speeds vary widely across OECD countries. Policymakers around the world, and especially in countries like the U.S. that lag in the rankings, are searching for policies to narrow those gaps. Relatively little empirical work tests possible reasons for these differences. In this paper I test the impacts of regulations and demographics on broadband development in a panel dataset across countries. In addition to adding to the meager empirical literature on broad...

Plants growing on contaminated and brownfield sites appropriate for use in Organisation for Economic Co-operation and Development terrestrial plant growth test.

Science.gov (United States)

Sinnett, Danielle E; Lawrence, Victoria K; Hutchings, Tony R; Hodson, Mark E

2011-01-01

The Organisation for Economic Co-operation and Development (OECD) terrestrial plant test is often used for the ecological risk assessment of contaminated land. However, its origins in plant protection product testing mean that the species recommended in the OECD guidelines are unlikely to occur on contaminated land. Six alternative species were tested on contaminated soils from a former Zn smelter and a metal fragmentizer with elevated concentrations of Cd, Cu, Pb, and Zn. The response of the alternative species was compared with that of two species recommended by the OECD: Lolium perenne (perennial ryegrass) and Trifolium pratense (red clover). Urtica dioica (stinging nettle) and Poa annua (annual meadowgrass) had low emergence rates in the control soil and so may be considered unsuitable. Festuca rubra (Chewings fescue), Holcus lanatus (Yorkshire fog), Senecio vulgaris (common groundsel), and Verbascum thapsus (great mullein) offer good alternatives to the OECD species. In particular, H. lanatus and S. vulgaris were more sensitive to the soils with moderate concentrations of Cd, Cu, Pb, and Zn than the OECD species. © 2010 SETAC.

Estonia ready to contribute to OECD / Ella Karapetyan

Index Scriptorium Estoniae

Karapetyan, Ella

2010-01-01

Eestis visiidil viibinud OECD peasekretär Angel Gurria kohtus president Toomas Hendrik Ilvese ja peaminister Andrus Ansipiga. Kohtumistel räägiti Eesti liitumisest OECD-ga. Andrus Ansip ja Angel Gurria kirjutasid alla Eesti ühinemislepingule OECD-ga

Guidelines for guideline developers: a systematic review of grading systems for medical tests

NARCIS (Netherlands)

Gopalakrishna, Gowri; Langendam, Miranda W.; Scholten, Rob J. P. M.; Bossuyt, Patrick M. M.; Leeflang, Mariska M. G.

2013-01-01

A variety of systems have been developed to grade evidence and develop recommendations based on the available evidence. However, development of guidelines for medical tests is especially challenging given the typical indirectness of the evidence; direct evidence of the effects of testing on patient

The Effect of Corruption on Government Expenditure Allocation in OECD Countries

Directory of Open Access Journals (Sweden)

Ondřej Jajkowicz

2015-01-01

Full Text Available This paper empirically examines the effect of corruption on the allocation of government expenditures by function. Equations using pooled panel dataset for 21 OECD countries between 1998 and 2011 were tested, and the findings show that government expenditure on defense and general public services increase, while government expenditures on education, health, recreation, culture and religion decline with higher levels of corruption. This paper presents new results and new evidence on the link between corruption and allocation of government expenditures in OECD countries.

Guidelines on the management of abnormal liver blood tests

Science.gov (United States)

Cramb, Rob; Davison, Suzanne M; Dillon, John F; Foulerton, Mark; Godfrey, Edmund M; Hall, Richard; Harrower, Ulrike; Hudson, Mark; Langford, Andrew; Mackie, Anne; Mitchell-Thain, Robert; Sennett, Karen; Sheron, Nicholas C; Verne, Julia; Walmsley, Martine; Yeoman, Andrew

2018-01-01

These updated guidelines on the management of abnormal liver blood tests have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the liver section of the BSG. The original guidelines, which this document supersedes, were written in 2000 and have undergone extensive revision by members of the Guidelines Development Group (GDG). The GDG comprises representatives from patient/carer groups (British Liver Trust, Liver4life, PBC Foundation and PSC Support), elected members of the BSG liver section (including representatives from Scotland and Wales), British Association for the Study of the Liver (BASL), Specialist Advisory Committee in Clinical Biochemistry/Royal College of Pathology and Association for Clinical Biochemistry, British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN), Public Health England (implementation and screening), Royal College of General Practice, British Society of Gastrointestinal and Abdominal Radiologists (BSGAR) and Society of Acute Medicine. The quality of evidence and grading of recommendations was appraised using the AGREE II tool. These guidelines deal specifically with the management of abnormal liver blood tests in children and adults in both primary and secondary care under the following subheadings: (1) What constitutes an abnormal liver blood test? (2) What constitutes a standard liver blood test panel? (3) When should liver blood tests be checked? (4) Does the extent and duration of abnormal liver blood tests determine subsequent investigation? (5) Response to abnormal liver blood tests. They are not designed to deal with the management of the underlying liver disease. PMID:29122851

OECD sarjab II samba peatamist / Erik Müürsepp

Index Scriptorium Estoniae

Müürsepp, Erik

2009-01-01

OECD peab II pensionisamba maksete peatamist taunitavaks. OECD dokumendist, milles vaadeldakse praegu kriisiolukorda sattunud riikide käitumist pensionisüsteemi kujundamisel. Sotsiaalminister Hanno Pevkuri arvamus OECD soovituste kohta

The Legitimation of OECD's Global Educational Governance: Examining PISA and AHELO Test Production

Science.gov (United States)

Morgan, Clara; Shahjahan, Riyad A.

2014-01-01

Although international student assessments and the role of international organisations (IOs) in governing education via an evidence-based educational policy discourse are of growing interest to educational researchers, few have explored the complex ways in which an IO, such as the OECD, gains considerable influence in governing education during…

Sensitivity Analysis of OECD Benchmark Tests in BISON

Energy Technology Data Exchange (ETDEWEB)

Swiler, Laura Painton [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gamble, Kyle [Idaho National Lab. (INL), Idaho Falls, ID (United States); Schmidt, Rodney C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Williamson, Richard [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-09-01

This report summarizes a NEAMS (Nuclear Energy Advanced Modeling and Simulation) project focused on sensitivity analysis of a fuels performance benchmark problem. The benchmark problem was defined by the Uncertainty Analysis in Modeling working group of the Nuclear Science Committee, part of the Nuclear Energy Agency of the Organization for Economic Cooperation and Development (OECD ). The benchmark problem involv ed steady - state behavior of a fuel pin in a Pressurized Water Reactor (PWR). The problem was created in the BISON Fuels Performance code. Dakota was used to generate and analyze 300 samples of 17 input parameters defining core boundary conditions, manuf acturing tolerances , and fuel properties. There were 24 responses of interest, including fuel centerline temperatures at a variety of locations and burnup levels, fission gas released, axial elongation of the fuel pin, etc. Pearson and Spearman correlatio n coefficients and Sobol' variance - based indices were used to perform the sensitivity analysis. This report summarizes the process and presents results from this study.

Testing post-editing guidelines

DEFF Research Database (Denmark)

Flanagan, Marian; Christensen, Tina Paulsen

2014-01-01

guidelines to use in translator training programmes. Recently, the first set of publicly available industry-focused PE guidelines (for ‘good enough’ and ‘publishable’ quality) were developed by Translation Automation User Society (TAUS) in partnership with the Centre for Global Intelligent Content (CNGL......), which can be used as a basis on which to instruct post-editors in professional environments. This paper reports on a qualitative study that investigates how trainee translators on an MA course, which is aimed at preparing the trainees for the translation industry, interpret these PE guidelines...... for publishable quality. The findings suggest trainees have difficulties interpreting the guidelines, primarily due to trainee competency gaps, but also due to the wording of the guidelines. Based on our findings we propose training measures to address these competency gaps. Furthermore, we provide post...

Climate change policies in the OECD

International Nuclear Information System (INIS)

Staahle, C.

1993-01-01

The author focuses on the United Nations Conference on the Environment and Development (UNCED), held in 1992 in Rio de Janeiro, Brasil, and on carbon taxation. At the UNCED the Framework Convention on Climate Change was signed by 154 countries. This convention is intended to guide policy makers, and takes into account the great differences that exist between countries with regard to their ability to cater and pay for greenhouse gas emission reductions. It is pointed out that since 1985 the share of CO 2 emissions from non-OECD countries has exceeded that of OECD countries. An overview is given of stated OECD targets on CO 2 emission reductions. The global impact of reductions in OECD countries alone will be limited: if all targets are met, global emissions will be growing with 19% in the coming ten years, compared to 22% in a 'business-as-usual' scenario. It was noted that only very few OECD countries have developed action plans or implemented carbon taxes that could make their targets attainable. Details were given on carbon taxes now in place. It is concluded that no progress will be made if developing countries are not included in climate change policies. Also much work remains to be done in developed countries to meet emission reduction or stabilization targets. 3 figs., 4 tabs

Guidelines for Standardized Testing of Broadband Seismometers and Accelerometers

Science.gov (United States)

Hutt, Charles R.; Evans, John R.; Followill, Fred; Nigbor, Robert L.; Wielandt, Erhard

2010-01-01

Testing and specification of seismic and earthquake-engineering sensors and recorders has been marked by significant variations in procedures and selected parameters. These variations cause difficulty in comparing such specifications and test results. In July 1989, and again in May 2005, the U.S. Geological Survey hosted international pub-lic/private workshops with the goal of defining widely accepted guidelines for the testing of seismological inertial sensors, seismometers, and accelerometers. The Proceedings of the 2005 workshop have been published and include as appendix 6 the report of the 1989 workshop. This document represents a collation and rationalization of a single set of formal guidelines for testing and specifying broadband seismometers and accelerometers.

Assessment of multi-dimensional analysis cacpacity of the MARS using the OECD-SETH PANDA tests

International Nuclear Information System (INIS)

Bae, S. W.; Jung, J. J.; Jung, B. D.

2004-01-01

The objectives of OECD/NEA-PANDA tests are to validate and assess computer codes that analyze the non-condensable gas concentrations and mixing phenomena in a reactor containment building. Especially, the main issue is multi-dimensional analysis capability which is involved in the mixing of non-condensable gases, i. e. hydrogen. The main tests consist of a superheated steam flow injection into a large vessel initially filled with air or air/helium mixtures. Then the temperature and concentration of noncondensable gases are measured. A pre-calculation has been performed with the MARS about PANDA Tests even though MARS is not a containment analysis code. Three cases among 25 PANDA Tests are selected and are modeled to simulate the jet plumes and air mixing in a large vessel. The dimensions of large vessel are 4 m diameter and 8 m height. For the conclusion of calculation, the cylindrical vessel which dimensions are 4 m diameter and 8 m height was simplified as rectangular geometry. It is revealed that the MARS code has the capability to distinguish the multi-dimensional distribution of the velocity and the temperature fields

Testing the hypothesis of the natural suicide rates: Further evidence from OECD data

DEFF Research Database (Denmark)

Andres, Antonio Rodriguez; Halicioglu, Ferda

2011-01-01

This paper provides further evidence on the hypothesis of the natural rate of suicide using the time series data for 15 OECD countries over the period 1970–2004. This hypothesis suggests that the suicide rate of a society could never be zero even if both the economic and the social conditions wer...

OECD Reviews of School Resources: Kazakhstan

Science.gov (United States)

Pons, Anna; Amoroso, Jeremie; Herczynski, Jan; Kheyfets, Igor; Lockheed, Marlaine; Santiago, Paulo

2015-01-01

This joint OECD-World Bank report for Kazakhstan forms part of the OECD Review of Policies to Improve the Effectiveness of Resource Use in Schools. The purpose of the Review is to explore how resources can be governed, distributed, utilised and managed to improve the quality, equity and efficiency of school education. School resources are…

Convergence and determinants of health expenditures in OECD countries.

Science.gov (United States)

Nghiem, Son Hong; Connelly, Luke Brian

2017-08-17

This study examines the trend and determinants of health expenditures in OECD countries over the 1975-2004 period. Based on recent developments in the economic growth literature we propose and test the hypothesis that health care expenditures in countries of similar economic development level may converge. We hypothesise that the main drivers for growth in health care costs include: aging population, technological progress and health insurance. The results reveal no evidence that health expenditures among OECD countries converge. Nevertheless, there is evidence of convergence among three sub-groups of countries. We found that the main driver of health expenditure is technological progress. Our results also suggest that health care is a (national) necessity, not a luxury good as some other studies in this field have found.

Procedure guideline for radioiodine test (version 3)

International Nuclear Information System (INIS)

Dietlein, M.; Schicha, H.; Eschner, W.; Deutsche Gesellschaft fuer Medizinische Physik; Koeln Univ.; Lassmann, M.; Deutsche Gesellschaft fuer Medizinische Physik; Wuerzburg Univ.; Leisner, B.; Allgemeines Krankenhaus St. Georg, Hamburg; Reiners, C.; Wuerzburg Univ.

2007-01-01

The version 3 of the procedure guideline for radioiodine test is an update of the guideline previously published in 2003. The procedure guideline discusses the pros and cons of a single measurement or of repeated measurements of the iodine-131 uptake and their optimal timing. Different formulas are described when one, two or three values of the radioiodine kinetic are available. The probe with a sodium-iodine crystal, alternatively or additionally the gamma camera using the ROI-technique are instrumentations for the measurement of iodine-131 uptake. A possible source of error is an inappropriate measurement (sonography) of the target volume. The patients' preparation includes the withdrawal of antithyroid drugs 2-3 days before radioiodine administration. The patient has to avoid iodine-containing medication and the possibility of additives of iodine in vitamin- and electrolyte-supplementation has to be considered. (orig.)

Activities of the OECD/NEA Data Bank and its computer program service

International Nuclear Information System (INIS)

Sartori, E.

1991-01-01

The OECD/NEA Data Bank collects, tests and distributes computer programs and numerical data in the field of nuclear energy applications. This activity is coordinated with several similar centres in the United States (NESC, NNDC, RSIC) and outside the OECD are through an arrangement with the IAEA. This valuable information is shared worldwide for the benefit of scientists and engineers working on the safe and economic use of nuclear energy for peaceful applications. This article covers mainly the activities of the computer program service. (author). 4 figs

OECD-LOFT large break LOCA experiments: phenomenology and computer code analyses

International Nuclear Information System (INIS)

Brittain, I.; Aksan, S.N.

1990-08-01

Large break LOCA data from LOFT are a very important part of the world database. This paper describes the two double-ended cold leg break tests LP-02-6 and LP-LB-1 carried out within the OECD-LOFT Programme. Tests in LOFT were the first to show the importance of both bottom-up and top-down quenching during blowdown in removing stored energy from the fuel. These phenomena are discussed in detail, together with the related topics of the thermal performance of nuclear fuel and its simulation by electric fuel rod simulators, and the accuracy of cladding external thermocouples. The LOFT data are particularly important in the validation of integral thermal-hydraulics codes such as TRAC and RELAP5. Several OECD partner countries contributed analyses of the large break tests. Results of these analyses are summarised and some conclusions drawn. 32 figs., 3 tabs., 45 refs

Spectrum Management Guidelines for National and Service Test and Training Ranges

Science.gov (United States)

2017-07-12

Frequency Management Group RCC 700-17 SPECTRUM MANAGEMENT GUIDELINES FOR NATIONAL AND SERVICE TEST AND TRAINING RANGES DISTRIBUTION...left blank. DOCUMENT 700-01 SPECTRUM MANAGEMENT GUIDELINES FOR NATIONAL AND SERVICE TEST AND TRAINING RANGES July 2017...Prepared by RANGE COMMANDERS COUNCIL FREQUENCY MANAGEMENT GROUP Published by Secretariat Range Commanders Council U.S. Army White

OECD - kvaliteedimärk kogu riigile / Keit Kasemets

Index Scriptorium Estoniae

Kasemets, Keit

2010-01-01

Majanduskoostöö ja Arengu Organisatsiooni (OECD) liikme staatus loob Eesti majanduspoliitika ja teiste oluliste poliitikate arendamisel uusi võimalusi. OECD faktides, praegused liikmesriigid ja nende liitumisaeg

Guidelines for European workplace drug testing in oral fluid.

Science.gov (United States)

Cooper, Gail; Moore, Christine; George, Claire; Pichini, Simona

2011-05-01

Over the past decade, oral fluid has established itself as a robust testing matrix for monitoring drug use or misuse. Commercially available collection devices provide opportunities to collect and test oral fluid by the roadside and near-patient testing with both clinical and criminal justice applications. One of the main advantages of oral fluid relates to the collection of the matrix which is non-invasive, simple, and can be carried out under direct observation making it ideal for workplace drug testing. Laboratories offering legally defensible oral fluid workplace drug testing must adhere to national and international quality standards (ISO/IEC 17025); however, these standards do not address issues specific to oral fluid testing. The European Workplace Drug Testing Society (EWDTS) recognizes the importance of providing best practice guidelines to organizations offering testing and those choosing to use oral fluid drug testing to test their employees. The aim of this paper is to present the EWDTS guidelines for oral fluid workplace drug testing. Copyright © 2011 John Wiley & Sons, Ltd.

Mollusc reproductive toxicity tests - Development and validation of test guidelines

DEFF Research Database (Denmark)

Ducrot, Virginie; Holbech, Henrik; Kinnberg, Karin Lund

. Draft standard operating procedures (SOPs) have been designed based upon literature and expert knowledge from project partners. Pre-validation studies have been implemented to validate the proposed test conditions and identify issues in performing the SOPs and analyzing test results. Pre-validation work......The Organisation for Economic Cooperation and Development is promoting the development and validation of mollusc toxicity tests within its test guidelines programme, eventually aiming for the standardization of mollusc apical toxicity tests. Through collaborative work between academia, industry...... and stakeholders, this study aims to develop innovative partial life-cycle tests on the reproduction of the freshwater gastropods Potamopyrgus antipodarum and Lymnaea stagnalis, which are relevant candidate species for the standardization of mollusc apical toxicity tests assessing reprotoxic effects of chemicals...

Activities of OECD NEA CSNI PWG3

International Nuclear Information System (INIS)

Miller, A.

1998-01-01

Activities of OECD NEA are connected with IAEA-IWG LMNPP, IAEA Nuclear safety, CEC-JRC, CEC-DG XI, CEC-DG XII and utilities UNIPEDE and WANO. The Committee on the Safety of Nuclear Installations (CSNI) acts through working groups on Fuel Cycle safety; Operating Experiences and Human Factors; Coolant System Behaviour; Integrity of Components and Structures; Confinement of Accidental Radioactive Releases and Risk Assessment. Korea, Mexico, Hungary and Czech Republic are now members of OECD NEA, and the non OECD Countries like Russia, Ukraine, Slovakia, Lithuania can participate in workshops but not in regular committee meetings

Developing Guidelines for HIV Antibody Testing among Victims of Pediatric Sexual Abuse.

Science.gov (United States)

Gellert, George A.; And Others

1990-01-01

An interim set of human immunodeficiency virus (HIV) testing guidelines for victims of pediatric sexual abuse (PSA) is proposed. Guidelines are based on responses of 63 practitioners of PSA assessment to 7 hypothetical clinical profiles with 12 testing criteria. (Author/DB)

Evaluation of HIV testing recommendations in specialty guidelines for the management of HIV indicator conditions

DEFF Research Database (Denmark)

Lord, E; Stockdale, A J; Malek, R

2017-01-01

OBJECTIVES: European guidelines recommend HIV testing for individuals presenting with indicator conditions (ICs) including AIDS-defining conditions (ADCs). The extent to which non-HIV specialty guidelines recommend HIV testing in ICs and ADCs is unknown. Our aim was to pilot a methodology in the UK...... are piloting methods to engage with guideline development groups to ensure that patients diagnosed with ICs/ADCs are tested for HIV. We then plan to apply our methodology in other European settings as part of the Optimising Testing and Linkage to Care for HIV across Europe (OptTEST) project....... to review specialty guidelines and ascertain if HIV was discussed and testing recommended. METHODS: UK and European HIV testing guidelines were reviewed to produce a list of 25 ADCs and 49 ICs. UK guidelines for these conditions were identified from searches of the websites of specialist societies...

OECD environmental performance reviews: United States

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-01-15

This book presents OECD assessments and recommendations regarding the United States' efforts to manage its environment including air, water, nature, and biodiversity; to do this in a sustainable manner; and to do this in co-operation with its global neighbours. In particular, it assesses progress made since 1996, when OECD's previous review on the US was done. 47 figs., 20 tabs.

IRS Guidelines: Joint IAEA/NEA International Reporting System for Operating Experience

International Nuclear Information System (INIS)

2010-01-01

The International Reporting System for Operating Experience (IRS) is an international system jointly operated by the International Atomic Energy Agency (IAEA) and the OECD Nuclear Energy Agency (OECD/NEA). The fundamental objective of the IRS is to contribute to improving the safety of commercial nuclear power plants which are operated worldwide. This objective can be achieved by providing timely and detailed information on lessons learned from operating and construction experience at the international level. This information could be related to issues and events that are related to safety. The purpose of these guidelines is to describe the system and to give users the necessary background and guidance to enable them to produce IRS reports meeting a high standard of quality while retaining the effectiveness of the system expected by all Member States operating nuclear power plants. As this system is owned by the Member States, the IRS Guidelines have been developed and approved by the IRS National Co-ordinators with the assistance of both Secretariats (IAEA/NEA).

OECD ukse avamine tooks siia raha / Harry Tuul

Index Scriptorium Estoniae

Tuul, Harry

2007-01-01

Poola pensionifondid ei taha Eestisse investeerida, sest Eesti ei kuulu Majandusliku Koostöö ja Arengu Organisatsiooni. Vt. samas: OECD liikmeskond; Romet Kreek. OECD ukse avamine tooks siia raha. Kommenteerib Andre Nõmm

OECD Halden reactor project

International Nuclear Information System (INIS)

1977-01-01

The activities of the OECD Halden Reactor Project for the year 1975 are summarized. The period under review is the last year of the three year joint programme which commenced on 1st January, 1973. The main items reported upon are: process supervision and control, test fuel irradiation and fuel research, reactor operations, and administration and finance. The process supervision and control work has been concentrated in two fields: methods development for core surveillance and control, and systems development for operator-process communication. As for fuel test, investigations of the densification phenomenon have continued through irradiations to a maximum of about 16000MWd/tUO 2 . Axial and radial deformations of fuel rods are studied, with the effect of power transients upon the dimensional stability of fuel rods, and fuel-cladding heat transfer and fuel temperature. Thermal models for steady state and transient heat transfer in fuel rods have been developed and the work on thermomechanical models of claddings shows considerable promise

OECD/NEA Radiological characterisation in decommissioning - Evaluation of questionnaire. Strategies for Radiological Characterisation used by Decommissioning Projects in OECD Countries

International Nuclear Information System (INIS)

Thierfeldt, Stefan; Haneke, K.

2012-01-01

In the first half of 2011, the Radiological Characterization and Decommissioning Task Group (RCD) of the WPDD of the OECD/NEA has prepared a questionnaire on the characterisation of nuclear facilities that has been circulated among nuclear installations in various OECD countries. The aim of this questionnaire was to gather information on the approaches and methods that are used for radiological characterisation (RC) for systems and components, for buildings and for sites (land), on domestic and international guidance and regulations that govern RC, and on the experience with RC that is already available in the particular country. The number of responses to this questionnaire that were received in the second half of 2011 was very satisfactory, so that a broad overview is now available from the following countries: Belgium, Canada, Denmark, Finland, France, Germany, Japan, Korea, Spain, Sweden, and United Kingdom. The presentation deals with the results that were obtained from the evaluation of these questionnaires and gives overviews of the objectives of characterisation, the input data for planning of characterisation, the measurement techniques that were used for metallic structures and components, for buildings and for sites, the data management and QA measures, the obstacles that were encountered, the experience with availability of as-built plans, the regulatory framework and guidelines, and the costs for RC. All information on RC is further broken down with respect to the operational phase (where RC is used for preliminary decommissioning planning), the transition phase (where RC supports decommissioning planning) and the actual decommissioning phase (where RC is needed for dismantling, decontamination and treatment of systems, components, buildings etc.). The presentation also offers conclusions on these subjects. (authors)

The OECD and Global Governance in Education

Science.gov (United States)

Sellar, Sam; Lingard, Bob

2013-01-01

This review essay discusses the history, evolution and development of the Organisation for Economic Co-operation and Development (OECD) and traces the growing impact of its education work. The essay is in four main sections. The first discusses Carrol and Kellow's "The OECD: A Study of Organizational Adaptation" (Edward Elgar) and…

Education at a Glance 2010: OECD Indicators

Science.gov (United States)

OECD Publishing (NJ1), 2010

2010-01-01

Across OECD countries, governments are seeking policies to make education more effective while searching for additional resources to meet the increasing demand for education. The 2010 edition of "Education at a Glance: OECD Indicators" enables countries to see themselves in the light of other countries' performance. It provides a rich, comparable…

OECD/NEA source convergence benchmark program: overview and summary of results

International Nuclear Information System (INIS)

Blomquist, Roger; Nouri, Ali; Armishaw, Malcolm; Jacquet, Olivier; Naito, Yoshitaka; Miyoshi, Yoshinori; Yamamoto, Toshihiro

2003-01-01

This paper describes the work of the OECD Nuclear Energy Agency Expert Group on Source Convergence in Criticality Safety Analysis. A set of test problems is presented, some computational results are given, and the effects of source convergence difficulties are described

An assessment of biodegradability of quaternary carbon-containing fragrance compounds: comparison of experimental OECD screening test results and in silico prediction data.

Science.gov (United States)

Seyfried, Markus; Boschung, Alain

2014-05-01

An assessment of biodegradability was carried out for fragrance substances containing quaternary carbons by using data obtained from Organisation for Economic Co-operation and Development (OECD) 301F screening tests for ready biodegradation and from Biowin and Catalogic prediction models. Despite an expected challenging profile, a relatively high percentage of common-use fragrance substances showed significant biodegradation under the stringent conditions applied in the OECD 301F test. Among 27 test compounds, 37% met the pass level criteria after 28 d, while another 26% indicated partial breakdown (≥20% biodegradation). For several compounds for which structural analogs were available, the authors found that structures that were rendered less water soluble by either the presence of an acetate ester or the absence of oxygen tended to degrade to a lesser extent compared to the primary alcohols or oxygenated counterparts under the test conditions applied. Difficulties were encountered when attempting to correlate experimental with in silico data. Whereas the Biowin model combinations currently recommended by regulatory agencies did not allow for a reliable discrimination between readily and nonbiodegradable compounds, only a comparably small proportion of the chemicals studied (30% and 63% depending on the model) fell within the applicability domain of Catalogic, a factor that critically reduced its predictive power. According to these results, currently neither Biowin nor Catalogic accurately reflects the potential for biodegradation of fragrance compounds containing quaternary carbons. © 2014 SETAC.

Vabariigi president kohtus OECD peasekretäriga

Index Scriptorium Estoniae

2008-01-01

President Toomas Hendrik Ilves kohtus 12. veebruaril 2008 Tallinnas Majandusliku Koostöö ja Arengu Organisatsiooni (OECD) peasekretäri Angel Gurria'ga, tänades teda panuse eest organisatsiooni laienemispoliitika edendamisel. Ilmunud ka: Meie Kodu 20. veebr. 2008, lk. 3, pealk.: President Ilves kohtus OECD peasekretäriga (Allk. Kristel Peterson)

Proceedings of the Second Meeting of the OECD-NEA Expert Group on Accident Tolerant Fuels for LWRs, 23-25 September 2014, OECD-NEA HQ

International Nuclear Information System (INIS)

Massara, S.; ); Bragg-Sitton, Shannon; Pasamehmetoglu, K.; Yang, Jae Ho; Dolley, Evan J.; Rebak, Raul B.; Sowder, Andrew; Cheng, Bo; Kurata, Masaki; Van Nieuwenhove, Rudi; Li, R.; McClellan, Ken; Nelson, Andy; Carmack, Jon; Harp, Jason; Finck, Phillip; ); Kakicuhi, K.

2014-09-01

Under the guidance of the OECD-NEA Nuclear Science Committee, the expert group acts as a forum for scientific and technical information exchange on advanced light water reactor (LWR) fuels with enhanced accident tolerance. The expert group focusses on the fundamental properties and behaviour under normal operations and accident conditions for advanced core materials and components (fuels, cladding, control rods, etc.). The materials considered are applicable to Gen II and Gen III Light Water Reactors, as well as Gen III+ reactors under construction. The objective of the expert group is to define and coordinate a programme of work to help advance the scientific knowledge needed to provide the technical underpinning for the development of advanced LWR fuels with enhanced accident tolerance compared to currently used zircaloy/UO 2 fuel systems, as well as other non-fuel core components with important roles in LWR performance under accident conditions. This document brings together the available presentations (slides) given at the Second Meeting of the OECD-NEA Expert Group on Accident Tolerant Fuels for LWRs. Content: 1 - Proposed Agenda; 2 - Expert Group meeting - 23 September 2014: - Introduction and background (S. Massara, OECD-NEA) - Expected outcomes from the TFs meetings scheduled on 24-25 September (K. Pasamehmetoglu, EG Chair, INL); 3 - Task Force 1 (Systems assessment) meeting - 24 September 2014: - Metrics for the Evaluation of LWR Accident Tolerant Fuel (S. Bragg-Sitton, INL); 4 - Task Force 2 (Cladding/core materials) meeting - 24 September 2014: - Summary on SiC Task Force 2 (Clad) meeting (J.H. Yang, KAERI); - Accident Tolerant Advanced Steels Cladding for Commercial Light Water Reactors (E. Dolley, GE); - Molybdenum-Alloy Fuel Cladding Development and Testing - Update from April 2014 NEA ATF Meeting (A. Sowder, EPRI); - Accident Tolerant Control Rod Development in Japan (M. Kurata, JAEA); - IFA-774: The first in-pile test with coated fuel rods (R. Van

Protective measures adopted in OECD member countries in response to the Chernobyl accident

International Nuclear Information System (INIS)

Yoshida, Yoshikazu

1988-01-01

The report outlines the measures for exposure prevention taken in West European countries following the Chernobyl power plant accident. In particular, the radioactivity regulation levels for foods (derived intervention levels) adopted in these countries are described in detail, citing from the reports of the Committee on Radiation Protection and Public Health of OECD/NEA (The Radiological Impact of the Chernobyl Accident in OECD Countries) and an scientific seminar held by EC (International Scientific Seminar on Foodstuffs Intervention Levels Following a Nuclear Accident). It is pointed out that these countries rather largely vary in measures taken and the derived intervention levels adopted although the principles for radiation protection which provide the basis for emergency protection measures must be nearly the same in all of the countries. It is necessary to establish consistent standards in each country in consideration of an accident, like the one at Chernobyl, that may have global effects. The ICRP recommendations and IAEA safety guidelines so far are centered on ''near-field'' measures to be taken in areas near an accident site. Thus, studies should be made to establish measures to be taken in areas far from the site. (Nogami, K.)

Japanese Society of Medical Oncology Clinical Guidelines: Molecular Testing for Colorectal Cancer Treatment, Third Edition.

Science.gov (United States)

Yamazaki, Kentaro; Taniguchi, Hiroya; Yoshino, Takayuki; Akagi, Kiwamu; Ishida, Hideyuki; Ebi, Hiromichi; Nakatani, Kaname; Muro, Kei; Yatabe, Yasushi; Yamaguchi, Kensei; Tsuchihara, Katsuya

2018-06-01

The Japanese Society of Medical Oncology (JSMO) previously published 2 editions of the clinical guidelines: "Japanese guidelines for testing of KRAS gene mutation in colorectal cancer" in 2008 and "Japanese Society of Medical Oncology Clinical Guidelines: RAS (KRAS/NRAS) mutation testing in colorectal cancer patients" in 2014. These guidelines have contributed to the proper use of KRAS and RAS mutation testing, respectively. Recently, clinical utility, particularly for colorectal cancer (CRC) patients with BRAF V600E mutation or DNA mismatch-repair (MMR) deficiency, has been established. Therefore, the guideline members decided these genetic alterations should also be involved. The aim of this revision is to properly carry out testing for BRAF V600E mutation and MMR deficiency in addition to RAS mutation. The revised guidelines include the basic requirements for testing for these genetic alterations based on recent scientific evidence. Furthermore, because clinical utility of comprehensive genetic testing using next-generation sequencing and somatic gene testing of analyzing circulating tumor DNA has increasingly evolved with recent advancements in testing technology, we noted the current situation and prospects for these testing technologies and their clinical implementation in the revised guidelines. © 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Guidelines for sea dumping packages of radioactive waste. Revised version.

International Nuclear Information System (INIS)

Anon.

1979-04-01

The purpose of these Guidelines is to establish general requirements and provide practical information for the design and manufacture of packages for sea dumping of radioactive waste, in accordance with the terms of the OECD Council Decision establishing a Multilateral Consultation and Surveillance Mechanism for Sea Dumping of Radioactive Waste. These Guidelines are in compliance with the IAEA Revised Definition and Recommendations of 1978, for applying the London Dumping Convention to radioactive waste, and are intended for application under the responsibility of the appropriate national authorities of countries participating in the NEA Mechanism

OECD/NEA source convergence benchmark program. Overview and summary of results

International Nuclear Information System (INIS)

Blomquist, Roger; Nouri, Ali; Armishaw, Malcolm; Jacquet, Olivier; Naito, Yoshitaka; Miyoshi, Yoshinori; Yamamoto, Toshihiro

2003-01-01

This paper describes the work of the OECD Nuclear Energy Agency Expert Group on Source Convergence in Criticality Safety Analysis. A set of test problems is presented, some computational results are given, and the effects of source convergence difficulties are described. (author)

Nuclear model codes and related software distributed by the OECD/NEA Data Bank

International Nuclear Information System (INIS)

Sartori, E.

1993-01-01

Software and data for nuclear energy applications is acquired, tested and distributed by several information centres; in particular, relevant computer codes are distributed internationally by the OECD/NEA Data Bank (France) and by ESTSC and EPIC/RSIC (United States). This activity is coordinated among the centres and is extended outside the OECD area through an arrangement with the IAEA. This article covers more specifically the availability of nuclear model codes and also those codes which further process their results into data sets needed for specific nuclear application projects. (author). 2 figs

How meaningful are risk determinations in the absence of a complete dataset? Making the case for publishing standardized test guideline and ‘no effect’ studies for evaluating the safety of nanoparticulates versus spurious ‘high effect’ results from single investigative studies

Science.gov (United States)

Warheit, David B.; Donner, E. Maria

2015-06-01

A recent review article critically assessed the effectiveness of published research articles in nanotoxicology to meaningfully address health and safety issues for workers and consumers. The main conclusions were that, based on a number of flaws in study designs, the potential risk from exposures to nanomaterials is highly exaggerated, and that no ‘nano-specific’ adverse effects, different from exposures to bulk particles, have been convincingly demonstrated. In this brief editorial we focus on a related tangential issue which potentially compromises the integrity of basic risk science. We note that some single investigation studies report specious toxicity findings, which make the conclusions more alarming and attractive and publication worthy. In contrast, the standardized, carefully conducted, ‘guideline study results’ are often ignored because they can frequently report no adverse effects; and as a consequence are not considered as novel findings for publication purposes, and therefore they are never considered as newsworthy in the popular press. Yet it is the Organization for Economic Cooperation and Development (OECD) type test guideline studies that are the most reliable for conducting risk assessments. To contrast these styles and approaches, we present the results of a single study which reports high toxicological effects in rats following low-dose, short-term oral exposures to nanoscale titanium dioxide particles concomitant with selective investigative analyses. Alternatively, the findings of OECD test guideline 408, standardized guideline oral toxicity studies conducted for 90 days at much higher doses (1000 mg kg-1) in male and female rats demonstrated no adverse effects following a very thorough and complete clinical chemical, as well as histopathological evaluation of all of the relevant organs in the body. This discrepancy in study findings is not reconciled by the fact that several biokinetic studies in rats and humans demonstrate little or

How meaningful are risk determinations in the absence of a complete dataset? Making the case for publishing standardized test guideline and ‘no effect’ studies for evaluating the safety of nanoparticulates versus spurious ‘high effect’ results from single investigative studies

International Nuclear Information System (INIS)

Warheit, David B; Donner, E Maria

2015-01-01

A recent review article critically assessed the effectiveness of published research articles in nanotoxicology to meaningfully address health and safety issues for workers and consumers. The main conclusions were that, based on a number of flaws in study designs, the potential risk from exposures to nanomaterials is highly exaggerated, and that no ‘nano-specific’ adverse effects, different from exposures to bulk particles, have been convincingly demonstrated. In this brief editorial we focus on a related tangential issue which potentially compromises the integrity of basic risk science. We note that some single investigation studies report specious toxicity findings, which make the conclusions more alarming and attractive and publication worthy. In contrast, the standardized, carefully conducted, ‘guideline study results’ are often ignored because they can frequently report no adverse effects; and as a consequence are not considered as novel findings for publication purposes, and therefore they are never considered as newsworthy in the popular press. Yet it is the Organization for Economic Cooperation and Development (OECD) type test guideline studies that are the most reliable for conducting risk assessments. To contrast these styles and approaches, we present the results of a single study which reports high toxicological effects in rats following low-dose, short-term oral exposures to nanoscale titanium dioxide particles concomitant with selective investigative analyses. Alternatively, the findings of OECD test guideline 408, standardized guideline oral toxicity studies conducted for 90 days at much higher doses (1000 mg kg −1 ) in male and female rats demonstrated no adverse effects following a very thorough and complete clinical chemical, as well as histopathological evaluation of all of the relevant organs in the body. This discrepancy in study findings is not reconciled by the fact that several biokinetic studies in rats and humans demonstrate

AAPM Medical Physics Practice Guideline 8.a.: Linear accelerator performance tests.

Science.gov (United States)

Smith, Koren; Balter, Peter; Duhon, John; White, Gerald A; Vassy, David L; Miller, Robin A; Serago, Christopher F; Fairobent, Lynne A

2017-07-01

The purpose of this guideline is to provide a list of critical performance tests in order to assist the Qualified Medical Physicist (QMP) in establishing and maintaining a safe and effective quality assurance (QA) program. The performance tests on a linear accelerator (linac) should be selected to fit the clinical patterns of use of the accelerator and care should be given to perform tests which are relevant to detecting errors related to the specific use of the accelerator. A risk assessment was performed on tests from current task group reports on linac QA to highlight those tests that are most effective at maintaining safety and quality for the patient. Recommendations are made on the acquisition of reference or baseline data, the establishment of machine isocenter on a routine basis, basing performance tests on clinical use of the linac, working with vendors to establish QA tests and performing tests after maintenance. The recommended tests proposed in this guideline were chosen based on the results from the risk analysis and the consensus of the guideline's committee. The tests are grouped together by class of test (e.g., dosimetry, mechanical, etc.) and clinical parameter tested. Implementation notes are included for each test so that the QMP can understand the overall goal of each test. This guideline will assist the QMP in developing a comprehensive QA program for linacs in the external beam radiation therapy setting. The committee sought to prioritize tests by their implication on quality and patient safety. The QMP is ultimately responsible for implementing appropriate tests. In the spirit of the report from American Association of Physicists in Medicine Task Group 100, individual institutions are encouraged to analyze the risks involved in their own clinical practice and determine which performance tests are relevant in their own radiotherapy clinics. © 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on

OECD Halden reactor project

International Nuclear Information System (INIS)

1979-01-01

This is the nineteenth annual Report on the OECD Halden Reactor Project, describing activities at the Project during 1978, the last year of the 1976-1978 Halden Agreement. Work continued in two main fields: test fuel irradiation and fuel research, and computer-based process supervision and control. Project research on water reactor fuel focusses on various aspects of fuel behavior under normal, and off-normal transient conditions. In 1978, participating organisations continued to submit test fuel for irradiation in the Halden boiling heavy-water reactor, in instrumented test assemblies designed and manufactured by the Project. Work included analysis of the impact of fuel design and reactor operating conditions on fuel cladding behavior. Fuel performance modelling included characterization of thermal and mechanical behavior at high burn-up, of fuel failure modes, and improvement of data qualification procedures to reduce and quantify error bands on in-reactor measurements. Instrument development yielded new or improved designs for measuring rod temperature, internal pressure, axial neutron flux shape determination, and for detecting cladding defects. Work on computer-based methods of reactor supervision and control included continued development of a system for predictive core surveillance, and of special mathematical methods for core power distribution control

OECD/NEA Sandia Fuel Project phase I: Benchmark of the ignition testing

Energy Technology Data Exchange (ETDEWEB)

Adorni, Martina, E-mail: martina_adorni@hotmail.it [UNIPI (Italy); Herranz, Luis E. [CIEMAT (Spain); Hollands, Thorsten [GRS (Germany); Ahn, Kwang-II [KAERI (Korea, Republic of); Bals, Christine [GRS (Germany); D' Auria, Francesco [UNIPI (Italy); Horvath, Gabor L. [NUBIKI (Hungary); Jaeckel, Bernd S. [PSI (Switzerland); Kim, Han-Chul; Lee, Jung-Jae [KINS (Korea, Republic of); Ogino, Masao [JNES (Japan); Techy, Zsolt [NUBIKI (Hungary); Velazquez-Lozad, Alexander; Zigh, Abdelghani [USNRC (United States); Rehacek, Radomir [OECD/NEA (France)

2016-10-15

Highlights: • A unique PWR spent fuel pool experimental project is analytically investigated. • Predictability of fuel clad ignition in case of a complete loss of coolant in SFPs is assessed. • Computer codes reasonably estimate peak cladding temperature and time of ignition. - Abstract: The OECD/NEA Sandia Fuel Project provided unique thermal-hydraulic experimental data associated with Spent Fuel Pool (SFP) complete drain down. The study conducted at Sandia National Laboratories (SNL) was successfully completed (July 2009 to February 2013). The accident conditions of interest for the SFP were simulated in a full scale prototypic fashion (electrically heated, prototypic assemblies in a prototypic SFP rack) so that the experimental results closely represent actual fuel assembly responses. A major impetus for this work was to facilitate severe accident code validation and to reduce modeling uncertainties within the codes. Phase I focused on axial heating and burn propagation in a single PWR 17 × 17 assembly (i.e. “hot neighbors” configuration). Phase II addressed axial and radial heating and zirconium fire propagation including effects of fuel rod ballooning in a 1 × 4 assembly configuration (i.e. single, hot center assembly and four, “cooler neighbors”). This paper summarizes the comparative analysis regarding the final destructive ignition test of the phase I of the project. The objective of the benchmark is to evaluate and compare the predictive capabilities of computer codes concerning the ignition testing of PWR fuel assemblies. Nine institutions from eight different countries were involved in the benchmark calculations. The time to ignition and the maximum temperature are adequately captured by the calculations. It is believed that the benchmark constitutes an enlargement of the validation range for the codes to the conditions tested, thus enhancing the code applicability to other fuel assembly designs and configurations. The comparison of

Renewable energy consumption and economic growth in nine OECD countries: bounds test approach and causality analysis.

Science.gov (United States)

Hung-Pin, Lin

2014-01-01

The purpose of this paper is to investigate the short-run and long-run causality between renewable energy (RE) consumption and economic growth (EG) in nine OECD countries from the period between 1982 and 2011. To examine the linkage, this paper uses the autoregressive distributed lag (ARDL) bounds testing approach of cointegration test and vector error-correction models to test the causal relationship between variables. The co-integration and causal relationships are found in five countries-United States of America (USA), Japan, Germany, Italy, and United Kingdom (UK). The overall results indicate that (1) a short-run unidirectional causality runs from EG to RE in Italy and UK; (2) long-run unidirectional causalities run from RE to EG for Germany, Italy, and UK; (3) a long-run unidirectional causality runs from EG to RE in USA, and Japan; (4) both long-run and strong unidirectional causalities run from RE to EG for Germany and UK; and (5) Finally, both long-run and strong unidirectional causalities run from EG to RE in only USA. Further evidence reveals that policies for renewable energy conservation may have no impact on economic growth in France, Denmark, Portugal, and Spain.

PREPARE: guidelines for planning animal research and testing.

Science.gov (United States)

Smith, Adrian J; Clutton, R Eddie; Lilley, Elliot; Hansen, Kristine E Aa; Brattelid, Trond

2018-04-01

There is widespread concern about the quality, reproducibility and translatability of studies involving research animals. Although there are a number of reporting guidelines available, there is very little overarching guidance on how to plan animal experiments, despite the fact that this is the logical place to start ensuring quality. In this paper we present the PREPARE guidelines: Planning Research and Experimental Procedures on Animals: Recommendations for Excellence. PREPARE covers the three broad areas which determine the quality of the preparation for animal studies: formulation, dialogue between scientists and the animal facility, and quality control of the various components in the study. Some topics overlap and the PREPARE checklist should be adapted to suit specific needs, for example in field research. Advice on use of the checklist is available on the Norecopa website, with links to guidelines for animal research and testing, at https://norecopa.no/PREPARE .

An empirical analysis of gasoline price convergence for 20 OECD countries

Energy Technology Data Exchange (ETDEWEB)

Bentzen, J.

2003-07-01

Two decades have passed now since the oil price shocks of the 1970s and since then energy prices have - apart from short periods of price instability - evolved relatively smoothly in the industrialized countries. Energy taxes in many countries differ markedly thereby causing differences in final energy prices, but as similar tax levels are becoming more common, e.g. in the European Union, convergence concerning energy prices might be expected to appear. In the present paper national gasoline price data covering the time period since the 1970s for a sample of OECD countries are used in order to test for this often addressed topic of convergence. The empirical part of the paper applies different time series based tests of convergence, where gasoline prices exhibit convergence for most OECD-Europe countries in the case where US$ is used for measurement of the energy prices indicating a convergence or tax harmonization process is taking place for these countries. (au)

An empirical analysis of gasoline price convergence for 20 OECD countries

International Nuclear Information System (INIS)

Bentzen, J.

2003-01-01

Two decades have passed now since the oil price shocks of the 1970s and since then energy prices have - apart from short periods of price instability - evolved relatively smoothly in the industrialized countries. Energy taxes in many countries differ markedly thereby causing differences in final energy prices, but as similar tax levels are becoming more common, e.g. in the European Union, convergence concerning energy prices might be expected to appear. In the present paper national gasoline price data covering the time period since the 1970s for a sample of OECD countries are used in order to test for this often addressed topic of convergence. The empirical part of the paper applies different time series based tests of convergence, where gasoline prices exhibit convergence for most OECD-Europe countries in the case where US$ is used for measurement of the energy prices indicating a convergence or tax harmonization process is taking place for these countries. (au)

A review of mammalian carcinogenicity study design and potential effects of alternate test procedures on the safety evaluation of food ingredients.

Science.gov (United States)

Hayes, A W; Dayan, A D; Hall, W C; Kodell, R L; Williams, G M; Waddell, W D; Slesinski, R S; Kruger, C L

2011-06-01

Extensive experience in conducting long term cancer bioassays has been gained over the past 50 years of animal testing on drugs, pesticides, industrial chemicals, food additives and consumer products. Testing protocols for the conduct of carcinogenicity studies in rodents have been developed in Guidelines promulgated by regulatory agencies, including the US EPA (Environmental Protection Agency), the US FDA (Food and Drug Administration), the OECD (Organization for Economic Co-operation and Development) for the EU member states and the MAFF (Ministries of Agriculture, Forestries and Fisheries) and MHW (Ministry of Health and Welfare) in Japan. The basis of critical elements of the study design that lead to an accepted identification of the carcinogenic hazard of substances in food and beverages is the focus of this review. The approaches used by entities well-known for carcinogenicity testing and/or guideline development are discussed. Particular focus is placed on comparison of testing programs used by the US National Toxicology Program (NTP) and advocated in OECD guidelines to the testing programs of the European Ramazzini Foundation (ERF), an organization with numerous published carcinogenicity studies. This focus allows for a good comparison of differences in approaches to carcinogenicity testing and allows for a critical consideration of elements important to appropriate carcinogenicity study designs and practices. OECD protocols serve as good standard models for carcinogenicity testing protocol design. Additionally, the detailed design of any protocol should include attention to the rationale for inclusion of particular elements, including the impact of those elements on study interpretations. Appropriate interpretation of study results is dependent on rigorous evaluation of the study design and conduct, including differences from standard practices. Important considerations are differences in the strain of animal used, diet and housing practices, rigorousness

OECD benchmark a of MOX fueled PWR unit cells using SAS2H, triton and mocup

International Nuclear Information System (INIS)

Ganda, F.; Greenspan, A.

2005-01-01

Three code systems are tested by applying them to calculate the OECD PWR MOX unit cell benchmark A. The codes tested are the SAS2H code sequence of the SCALE5 code package using 44 group library, MOCUP (MCNP4C + ORIGEN2), and the new TRITON depletion sequence of SCALE5 using 238 group cross sections generated using CENTRM with continuous energy cross sections. The burnup-dependent k ∞ and actinides concentration calculated by all three code-systems were found to be in good agreement with the OECD benchmark average results. Limited results were calculated also with the WIMS-ANL code package. WIMS-ANL was found to significantly under-predict k ∞ as well as the concentration of Pu 242 , consistently with the predictions of the WIMS-LWR reported by two of the OECD benchmark participants. Additionally, SAS2H is benchmarked against MOCUP for a hydride fuel containing unit cell, giving very satisfactory agreement. (authors)

Results of extended plant tests using more realistic exposure scenarios for improving environmental risk assessment of veterinary pharmaceuticals

OpenAIRE

Richter, Elisabeth; Berkner, Silvia; Ebert, Ina; Förster, Bernhard; Graf, Nadin; Herrchen, Monika; Kuehnen, Ute; Römbke, Jörg; Simon, Markus

2016-01-01

Background Residues of veterinary medicinal products (VMPs) enter the environment via application of manure onto agricultural areas where in particular antibiotics can cause phytotoxicity. Terrestrial plant tests according to OECD guideline 208 are part of the environmental risk assessment of VMPs. However, this standard approach might not be appropriate for VMPs which form non-extractable residues or transformation products in manure and manure-amended soil. Therefore, a new test design with...

76 FR 34086 - Mandatory Guidelines for Federal Workplace Drug Testing Programs; Request for Information...

Science.gov (United States)

2011-06-10

... Mandatory Guidelines for Federal Workplace Drug Testing Programs; Request for Information Regarding Specific Issues Related to the Use of the Oral Fluid Specimen for Drug Testing AGENCY: Substance Abuse and Mental... may be applied to the Mandatory Guidelines for Federal Workplace Drug Testing Programs (oral fluid...

OECD Reviews of School Resources : Austria 2016

OpenAIRE

Theisens, Henno

2016-01-01

The effective use of school resources is a policy priority across OECD countries. The OECD Reviews of School Resources explore how resources can be governed, distributed, utilised and managed to improve the quality, equity and efficiency of school education. The series considers four types of resources: financial resources, such as public funding of individual schools; human resources, such as teachers, school leaders and education administrators; physical resources, such as location, buildin...

Guidelines for confirmatory inplant tests of safety-relief valve discharges for BWR plants

International Nuclear Information System (INIS)

Su, T.M.

1981-05-01

Inplant tests of safety/relief valve (SRV) discharges may be required to confirm generically established specifications for SRV loads and the maximum suppression pool temperature, and to evaluate possible effects of plant-unique parameters. These tests are required in those plants which have features that differ substantially from those previously tested. Guidelines for formulating appropriate test matrices, establishing test procedures, selecting necessary instrumentation, and reporting the test results are provided in this report. Guidelines to determine if inplant tests are required on the basis of the plant unique parameters are also included in the report

Road accidents at night in the Netherlands : a national analysis according to official road accident data. Contribution to OECD Research Group TS 3 on Improving Road Safety at Night.

NARCIS (Netherlands)

Harris, S.

1979-01-01

The questionnaire about night-time accident data of the OECD Research Group TS 3 on Improving Road Safety at Night was filled in for the Netherlands. Thereafter a national analysis was written, using the already completed accident data questionnaire. Guidelines for the contents and presentation

OECD/SERENA Project Report. Summary and Conclusions

International Nuclear Information System (INIS)

2015-02-01

The OECD/SERENA Project Integration Report summarises the outcome of a broad range of activities conducted in the framework of the Organisation for Economic Cooperation and Development (OECD) Steam Explosion Resolution for Nuclear Applications Project (OECD/SERENA) to address remaining issues on fuel-coolant interaction (FCI) mechanisms and their effect on ex-vessel steam explosion energetics. The scope the OECD/SERENA project was to resolve uncertainties in the remaining issues and to bring the code capabilities to an adequate level for use in reactor safety applications. This scope was accomplished with the completion of three major tasks: (1) an experimental programme consisting of two sets of steam explosion experiments in two different facilities; (2) an analytical programme consisting of pre-test calculations in support of test specifications and post-test calculations in support of data analysis and code assessment, and also a code benchmark exercise; and (3) a reactor calculation exercise repeating the one performed in the framework of the CSNI/WGAMA SERENA activity performed from 2001 to 2006 (also referred to as SERENA Phase I, published as CSNI/R(2007)/11). The objectives of the experimental programme were to provide data: (1) to clarify the explosion behaviour of prototypic corium melts and for validation of steam explosion models for prototypic materials; and (2) for steam explosion behaviour in two different geometries to verify the geometrical extrapolation capabilities of the codes. These objectives were to be accomplished by conducting complementary sets of six experiments each at two different facilities: KROTOS at the Commissariat l'Energie Atomique et aux Energies Alternatives (CEA) in Cadarache, France, representing one-dimensional FCI configuration involving nominally 5 kilograms of prototypic corium melt, and TROI at Korea Atomic Energy Research Institute (KAERI) in Daejeon, Korea, representing multi-dimensional FCI configuration

Energy consumption and economic growth nexus for 17 highly developed OECD countries: Further evidence based on bootstrap-corrected causality tests

International Nuclear Information System (INIS)

Yildirim, Ertugrul; Aslan, Alper

2012-01-01

Unlike previous energy consumption-economic growth studies, this study examines the relationship among energy consumption, economic growth, employment and gross fixed capital formation for 17 highly developed OECD countries by employing both the Toda–Yamamoto procedure which based on asymptotic critical values and the bootstrap-corrected causality test, since non-normality of the error term harms the validity of the Toda–Yamamoto procedure. This study finds that there is very small bias due to the assumption of normality. Furthermore using different information criterions, importance of lag length is tested. Findings indicate that selection of lag length is important for Denmark, Ireland, Norway and Spain. It is concluded that while there exists uni-directional causality running from energy consumption to real GDP for Japan, bi-directional causality is found for Italy, New Zealand, Norway and Spain. On the other hand, uni-directional causality from GDP to energy is found for Australia, Canada and Ireland whereas no causal nexus is found for all of other nine countries. Our analyses covering the sample periods imply that Japan, Italy, New Zealand, Norway and Spain should not follow energy conservation policy at the aggregated level, since the reduction of energy damages the economic growth. - Highlights: ► This study examines energy consumption, economic growth linkage for 17 developed OECD countries. ► Lag length selection is important for Denmark, Ireland, Norway and Spain. ► There exists uni-directional causality running from energy consumption to real GDP for Japan. ► Bi-directional causality is found for Italy, New Zealand, Norway and Spain.

Joint IAEA/NEA IRS guidelines

International Nuclear Information System (INIS)

1997-01-01

The Incident Reporting System (IRS) is an international system jointly operated by the International Atomic Energy Agency (IAEA) and the Nuclear Energy Agency of the Organization for Economic Cooperation and Development (OECD/NEA). The fundamental objective of the IRS is to contribute to improving the safety of commercial nuclear power plants (NPPs) which are operated worldwide. This objective can be achieved by providing timely and detailed information on both technical and human factors related to events of safety significance which occur at these plants. The purpose of these guidelines, which supersede the previous IAEA Safety Series No. 93 (Part II) and the NEA IRS guidelines, is to describe the system and to give users the necessary background and guidance to enable them to produce IRS reports meeting a high standard of quality while retaining the high efficiency of the system expected by all Member States operating nuclear power plants

Eesti allkirjastas liitumislepingu OECD-ga

Index Scriptorium Estoniae

2010-01-01

Peaminister Andrus Ansip ja OECD peasekretär Angel Gurria allkirjastasid 3. juunil 2010. a. Stenbocki majas Eesti liitumislepingu. Samal päeval kohtus president Toomas Hendrik Ilves Angel Gurriaga Kadriorus

77 FR 66149 - Significant New Use Rules on Certain Chemical Substances

Science.gov (United States)

2012-11-02

... 835.5045 or OECD Test Guideline 302A); a UV/visible absorption test (OPPTS Test Guideline 830.7050... precipitate used to produce phosphors. Based on test data on analogous chemical substances, EPA identified...

75 FR 22809 - Mandatory Guidelines for Federal Workplace Drug Testing Programs

Science.gov (United States)

2010-04-30

... time for related training in Federal and federally-regulated workplace drug testing programs and will... related training in Federal and federally-regulated workplace drug testing programs, including HHS... DEPARTMENT OF HEALTH AND HUMAN SERVICES Mandatory Guidelines for Federal Workplace Drug Testing...

75 FR 5546 - Proposed Significant New Use Rule for Multi-walled Carbon Nanotubes

Science.gov (United States)

2010-02-03

... effects of the PMN substance: A bacterial reverse mutation test (OPPTS Harmonized Test Guideline 870.5100) in vitro; a mammalian erythrocyte micronucleus test (OPPTS Harmonized Test Guideline 870.5395 or Organisation for Economic Co-operation and Development (OECD) 474 test guideline) in vivo, in bone marrow, by...

Energy demand in seven OECD countries

International Nuclear Information System (INIS)

Patry, M.

1990-01-01

The intensity of utilization of energy has been declining in all OECD countries since the first oil price shock of 1973. In 1988, the OECD countries were consuming 1.7 billion tonnes of crude oil, that is two hundred million tonnes less than fifteen years ago. From 1974 to 1988, OECD oil consumption decreased at an average annual rate of 1.3% while the GDP of these countries rose by an average of 2.6% per annum. The authors present here a model of sectoral energy demand and interfuel substitution for the G-7 countries: Canada, France, Germany, Italy, Japan, the United Kingdom and the United States. The ultimate goal is to determine the relative importance of the contributing factors to the observed reversal in energy consumption per unit of production in these countries. The results they present should be viewed as preliminary. They point in the paper to a number of extensions that should improve the theoretical quality of the modeling effort and the statistical robustness of the results. They are presently expanding the data set to pinpoint more adequately the effects of structural change and conservation

Activities of the OECD-NEA in the field of fast reactors

International Nuclear Information System (INIS)

Royen, J.

1977-01-01

The OECD-NEA is performing the following activities in the field of fast reactors: Held ad hoc meetings of senior experts on safety, development and economics of LMFBR type reactors; publishing a Nuclear Safety Research Index (the index is now expanded to cover fast reactors) and distribution; collect test computer programmes, as well as neutron data

The OECD/NEA Data Bank, its computer program services and benchmarking activities

International Nuclear Information System (INIS)

Sartori, E.; Galan, J.M.

1998-01-01

The OECD/NEA Data Bank collects, tests and distributes computer programs and numerical data in the field of nuclear energy applications. This activity is coordinated with several similar centres in the United States (ESTSC, NNDC, RSIC) and outside the OECD area through an arrangement with the IAEA. This information is shared worldwide for the benefit of scientists and engineers working on the safe and economic use of nuclear energy. The OECD/NEA Nuclear Science Committee the supervising body of the Data Bank has conducted a series of international computer code benchmark exercises with the aim of verifying the correctness of codes, of building confidence in models used for predicting macroscopic behaviour of nuclear systems and to drive towards refinement of models where necessary. Exercises involving nuclear cross section predictions, in-core reactor physics issues, such as pin cells for different type of reactors, plutonium recycling, reconstruction of pin power within assemblies, core transients, reactor shielding and dosimetry, away from reactor issues such as criticality safety for transport and storage of spent fuel, shielding of radioactive material packages and other problems connected with the back end of the fuel cycle, are listed and the relevant references provided. (author)

Mismatch Repair Deficiency Testing in Patients With Colorectal Cancer and Nonadherence to Testing Guidelines in Young Adults.

Science.gov (United States)

Shaikh, Talha; Handorf, Elizabeth A; Meyer, Joshua E; Hall, Michael J; Esnaola, Nestor F

2018-02-08

Mismatch repair (MMR) deficiency of DNA has been observed in up to 15% of sporadic colorectal cancers (CRCs) and is a characteristic feature of Lynch syndrome, which has a higher incidence in young adults (age, testing in adults with CRC and analyze nonadherence to long-standing testing guidelines in younger adults using a contemporary national data set to help identify potential risk factors for nonadherence to newly implemented universal testing guidelines. Adult (age, testing status were identified using the National Cancer Database. The study was conducted from March 16, 2016, to March 1, 2017. Patient sociodemographic, facility, tumor, and treatment characteristics. The primary outcome of interest was receipt of MMR deficiency testing. Multivariable logistic regression was used to identify independent predictors of testing in adult and/or young adult patients. A total of 152 993 adults with CRC were included in the study (78 579 [51.4%] men; mean [SD] age, 66.9 [13.9] years). Of these patients, only 43 143 (28.2%) underwent MMR deficiency testing; the proportion of patients tested increased between 2010 and 2012 (22.3% vs 33.1%; Ptesting; the proportion tested increased between 2010 and 2012 (36.1% vs 48.0%; P testing, whereas older age (OR, 0.31; 95% CI, 0.26-0.37); Medicare (OR, 0.89; 95% CI, 0.84-0.95), Medicaid (OR, 0.83; 95% CI, 0.73-0.93), or uninsured (OR, 0.78; 95% CI, 0.66-0.92) status; nonacademic vs academic/research facility type (OR, 0.44; 95% CI, 0.34-0.56); rectosigmoid or rectal tumor location (OR, 0.76; 95% CI, 0.68-0.86); unknown grade (OR, 0.61; 95% CI, 0.53-0.69); and nonreceipt of definitive surgery (OR, 0.33; 95% CI, 0.30-0.37) were associated with underuse of MMR deficiency testing. Despite recent endorsement of universal use of MMR deficiency testing in patients with CRC and well-established guidelines aimed at high-risk populations, overall utilization of testing is poor and significant underuse of testing among young adults

Practical Application of Art. 9 OECD Model Convention: the Czech Republic

Directory of Open Access Journals (Sweden)

Veronika Solilová

2014-01-01

Full Text Available All transfer prices determined between the associated enterprises must comply with the arm’s length principle. The arm’s length principle for associated enterprises is mentioned in Art. 9(1 of the OECD Model Convention, which was also adopted by the OECD Member states into their national law. However, not all OECD Member states adopted the next part of Art. 9, namely Art. 9(2, with the same way, some of them, like the Czech Republic, entered a reservation on Art. 9 (2 OECD Model Convention. In this paper the practical application of Art. 9 is analyzed from the point of view of the Czech Ministry of Finance, where the corresponding adjustment and time-limit issue are highlighted. On the basis of the results of analysis, where the history, context and purpose of Art. 9 OECD Model Convention have to be taken into account, are made some recommendations.

Guideline on in-service testing (IST) of ECCS for nuclear power stations in Japan

International Nuclear Information System (INIS)

Yamashita, N.; Honjin, M.; Yamazaki, M.; Iwami, H.

2001-01-01

In Japan, METI (Ministry of Economy, Trade and Industry) periodic inspections are conducted every 13 months in accordance with the EUIL (Electric Utility Industry Law) for light water reactors. On the other hand, during operation, many kinds of function tests are conducted in accordance with Technical Specifications or utilities voluntary test procedures. However, these maintenance activities during outages are in other respects considered too costly and more than necessary because of its predetermined maintenance interval and its old-fashioned full scope maintenance menu. In these circumstances, the ASME O and M Codes and Standards, which are applied to nuclear power plants in the United States, came to be one of the issues to be considered among Japanese utilities. This is because the ASME O and M Codes and Standards, which are developed to verify the operational readiness of equipment or systems by condition based maintenance or performance testing without overhauls, will be considered to suggest a rational alternative to our existing maintenance activities. Because there had been no standard for function tests other than the METI inspection procedures in Japan, activities started for the development of Japanese Operation and Maintenance Guideline (hereinafter called the Japanese OM Guideline or the Guideline) for function tests and condition monitoring. The Japanese OM Guideline is not proclaimed for regulatory use, but the long-term objective is to provide a substantial basis to change the current maintenance activities including regulatory inspection. The Guideline is composed of five parts, which are general requirements, pumps, valves, snubbers and ECCS systems. This paper gives a summary of the ECCS part of the Japanese OM Guideline, in particular, focusing on the differences between the Guideline and the ASME O and M Standards, and topics or discussion during their establishment. (author)

Gas Flow Validation with Panda Tests from the OECD SETH Benchmark Covering Steam/Air and Steam/Helium/Air Mixtures

International Nuclear Information System (INIS)

Royl, P.; Travis, J.R.; Breitung, W.; Kim, J.; Kim, S.B.

2009-01-01

The CFD code GASFLOW solves the time-dependent compressible Navier-Stokes Equations with multiple gas species. GASFLOW was developed for nonnuclear and nuclear applications. The major nuclear applications of GASFLOW are 3D analyses of steam/hydrogen distributions in complex PWR containment buildings to simulate scenarios of beyond design basis accidents. Validation of GASFLOW has been a continuously ongoing process together with the development of this code. This contribution reports the results from the open posttest GASFLOW calculations that have been performed for new experiments from the OECD SETH Benchmark. Discussed are the steam distribution tests 9 and 9 bis, 21 and 21 bis involving comparable sequences with and without steam condensation and the last SETH test 25 with steam/helium release and condensation. The latter one involves lighter gas mixture sources like they can result in real accidents. The helium is taken as simulant for hydrogen

Best-practices guidelines for L2PSA development and applications. Volume 1 - General

International Nuclear Information System (INIS)

Raimond, E.; Pichereau, F.; Durin, T.; Rahni, N.; Loeffler, H.; Roesch, O.; Lajtha, G.; Santamaria, C.S.; Dienstbier, J.; Rydl, A.; Holmberg, J.E.; Lindholm, I.; Maennistoe, I.; Pauli, E.M.; Dirksen, G.; Grindon, L.; Peers, K.; Bassi, C.; Hulqvist, G.; Parozzi, F.; Polidoro, F.; Cazzoli, E.; Vitazkova, J.; Burgazzi, L.; Brinkman, H.; Seidel, A.; Schubert, B.; Wohlstein, R.; Guentay, S.; Oury, L.; Ngatchou, C.; Siltanen, S.; Niemela, I.; Routamo, T.; Vincon, L.; Helstroem, P.

2010-01-01

The objective of this coordinated action was to develop best practice guidelines for the performance and application of Level 2 PSA with a view to achieve harmonisation at EU level and to allow a meaningful and practical uncertainty evaluation in a Level 2 PSA. Specific relationships with communities in charge of nuclear reactor safety (utilities, safety authorities, vendors, and research or services companies) have been established in order to define the current needs in terms of guidelines for Level 2 PSA development and application. An international workshop was organised in Hamburg, with the support of VATTENFALL, in November 2008. The Level 2 PSA experts from ASAMPSA2 project partners have proposed some guidelines for the development and application of L2PSA based on their experience, open literature, and on information available from international cooperation (EC Severe Accident network of Excellence - SARNET, IAEA standards, OECD-NEA publications and workshop). There are a large number of technical issues addressed in the guideline which are not all covered with the same level of detail in the first version of the guideline. This version was submitted for external review in November 2010 by severe accident and PSA experts (especially from SARNET and OECD-NEA members). The feedback of the external review will be dis cussed during an international open works hop planned for March 2011 and all outcomes will be taken into consideration in the final version of this guideline (June 2011). The guideline includes 3 volumes: - Volume 1 - General considerations on L2PSA. - Volume 2 - Technical recommendations for Gen II and III reactors. - Volume 3 - Specific considerations for future reactors (Gen IV). The recommendations formulated in the guideline should not be considered as 'mandatory' but should help Level 2 PSA developers to achieve high quality studies with limited time and resources. It may also help Level 2 PSA reviewers by positioning one specific study in

Energy statistics and balances of non-OECD countries 1991-1992

International Nuclear Information System (INIS)

1994-01-01

Contains a compilation of energy production and consumption statistics for 85 non-OECD countries and regions, including developing countries, Central and Eastern European countries and the former Soviet Union. Data are expressed in original units and in common units for coal, oil, gas, electricity and heat. Historical tables for both individual countries and regions summarize data on coal, gas and electricity production and consumption since 1971. Similar data for OECD are available in the IEA publications Energy Statistics and Energy Balances of OECD Countries

20. Annual report. OECD Halden reactor project. 1979

International Nuclear Information System (INIS)

1981-01-01

This is the Twentieth Annual Report on the OECD Halden Reactor Project, describing activities during 1979, the first year of the 1979-1981 Halden Agreement. Research work at the project is focussed on three areas: 1) In-core behaviour of reactor fuel, particularly reliability and safety aspects, which is studied through irradiation of test fuel elements. 2) Prediction, surveillance and control of fuel and core performance, for which models of fuel and core behaviour are developed. 3) Applications of process computers to power plant control, for which prototype software systems and hardware arrangements are developed

Guideline for the licensing of various designs of ionisation smoke alarms

International Nuclear Information System (INIS)

1978-01-01

The purpose of the guideline is to set up criteria for the construction licensing of ionisation smoke alarms and to determine their use. This guarantees that only those ISA are licensed which correspond to the level of science and technology and that the ISA to be licensed fulfills the demands of radiation protection. The recommendations of OECD/NEA are also born in mind. (orig./HP) [de

Critical power prediction by CATHARE2 of the OECD/NRC BFBT benchmark

Energy Technology Data Exchange (ETDEWEB)

Lutsanych, Sergii, E-mail: s.lutsanych@ing.unipi.it [San Piero a Grado Nuclear Research Group (GRNSPG), University of Pisa, Via Livornese 1291, 56122, San Piero a Grado, Pisa (Italy); Sabotinov, Luben, E-mail: luben.sabotinov@irsn.fr [Institut for Radiological Protection and Nuclear Safety (IRSN), 31 avenue de la Division Leclerc, 92262 Fontenay-aux-Roses (France); D’Auria, Francesco, E-mail: francesco.dauria@dimnp.unipi.it [San Piero a Grado Nuclear Research Group (GRNSPG), University of Pisa, Via Livornese 1291, 56122, San Piero a Grado, Pisa (Italy)

2015-03-15

Highlights: • We used CATHARE code to calculate the critical power exercises of the OECD/NRC BFBT benchmark. • We considered both steady-state and transient critical power tests of the benchmark. • We used both the 1D and 3D features of the CATHARE code to simulate the experiments. • Acceptable prediction of the critical power and its location in the bundle is obtained using appropriate modelling. - Abstract: This paper presents an application of the French best estimate thermal-hydraulic code CATHARE 2 to calculate the critical power and departure from nucleate boiling (DNB) exercises of the International OECD/NRC BWR Fuel Bundle Test (BFBT) benchmark. The assessment activity is performed comparing the code calculation results with available in the framework of the benchmark experimental data from Japanese Nuclear Power Engineering Corporation (NUPEC). Two-phase flow calculations on prediction of the critical power have been carried out both in steady state and transient cases, using one-dimensional and three-dimensional modelling. Results of the steady-state critical power tests calculation have shown the ability of CATHARE code to predict reasonably the critical power and its location, using appropriate modelling.

Overview of the OECD Halden reactor project

International Nuclear Information System (INIS)

Vitanza, C.

2000-01-01

The OECD Halden Reactor Project is an international network dedicated to enhancing the safety and reliability of nuclear power plants. The project operates under the auspices of the OECD Nuclear Energy Agency and aims at addressing and resolving issues relevant to safety as they emerge in the nuclear community. This paper gives a concise presentation of the project's goals and of its technical infrastructure. The paper also contains a brief overview of results from the ongoing programme and of the main issues contemplated for the next three-year programme period (2000-2002). (author)

OECD Halden Reactor Project

International Nuclear Information System (INIS)

1988-01-01

The OECD Halden Reactor project is an agreement between OECD member countries. It was first signed in 1958 and since then regularly renewed every third year. The activities at the Project is centred around the Halden heavy water rector, the HBWR. The reseach programme comprizes studies of fuel performance under various operating conditions, and the application of computers for process control. The HBWR is equipped for exposing fuel rods to temperatures and pressures, and at heat ratings met in modern BWR's and PWR's. A range of in-core instruments are available, permitting detailed measurements of the reactions of the fuel, including mechanical deformations, thermal behaviour, fission gas release, and corrosion. In the area of computer application, the studies of the communication between operator and process, and the surveillance and control of the reactor core, are of particular interst for reactor operation. 1988 represents the 30th year since the Project was started, and this publication is produced to mark this event. It gives and account of the activities and achievements of the Project through the years 1958-1988

Inspector qualification guidelines

International Nuclear Information System (INIS)

Batty, A.C.; Van Binnebeek, J.J.; Ericsson, P.O.; Fisher, J.C.; Geiger, P.; Grandame, M.; Grimes, B.K.; Joode, A. de; Kaufer, B.; Kinoshita, M.; Klonk, H.; Koizumi, H.; Maeda, N.; Maqua, M.; Perez del Moral, C.; Roselli, F.; Warren, T.; Zimmerman, R.

1994-07-01

The OECD Nuclear Energy Agency Committee on Nuclear Regulatory Activities (CNRA) has a Working Group on Inspection Practices (WGIP). The WGIP provides a forum for the exchange of Information and experience on the safety Inspection practices of regulatory authorities In the CNRA member countries. A consistent qualification process and well defined level of training for all Inspectors who participate In the safety Inspections are needed to provide consistent Inspections and reliable Inspection results. The WGIP organized in 1992 a workshop on the conduct of inspections, inspector qualification and training, and shutdown inspections at the Technical Training Center of the US NRC in Chattanooga, Tennessee. In the connection of workshop the WGIP identified a need to develop guidance for inspector qualification which could be used as a model by those who are developing their qualification practices. The inspector qualification journals of US NRC provided a good basis for the work. The following inspector qualification guideline has been developed for guidance of qualification of a new inspector recruited to the regulatory body. This guideline has been developed for helping the supervisors and training officers to give the initial training and familiarization to the duties of a new inspector in a controlled manner. US NRC inspector qualification journals have been used to define the areas of attention. This guideline provides large flexibility for application in different type organizations. Large organizations can develop separate qualification journals for each inspector positions. Small regulatory bodies can develop individual training programmes by defining the necessary training topics on case by case basis. E.g. the guideline can be used to define the qualifications of contracted inspectors used in some countries. The appropriate part would apply. Annex 1 gives two examples how this guideline could be applied

Inspector qualification guidelines

Energy Technology Data Exchange (ETDEWEB)

Batty, A. C.; Van Binnebeek, J. J.; Ericsson, P. O.; Fisher, J. C.; Geiger, P.; Grandame, M.; Grimes, B. K.; Joode, A. de; Kaufer, B.; Kinoshita, M.; Klonk, H.; Koizumi, H.; Maeda, N.; Maqua, M.; Perez del Moral, C.; Roselli, F.; Warren, T.; Zimmerman, R.

1994-07-15

The OECD Nuclear Energy Agency Committee on Nuclear Regulatory Activities (CNRA) has a Working Group on Inspection Practices (WGIP). The WGIP provides a forum for the exchange of Information and experience on the safety Inspection practices of regulatory authorities In the CNRA member countries. A consistent qualification process and well defined level of training for all Inspectors who participate In the safety Inspections are needed to provide consistent Inspections and reliable Inspection results. The WGIP organized in 1992 a workshop on the conduct of inspections, inspector qualification and training, and shutdown inspections at the Technical Training Center of the US NRC in Chattanooga, Tennessee. In the connection of workshop the WGIP identified a need to develop guidance for inspector qualification which could be used as a model by those who are developing their qualification practices. The inspector qualification journals of US NRC provided a good basis for the work. The following inspector qualification guideline has been developed for guidance of qualification of a new inspector recruited to the regulatory body. This guideline has been developed for helping the supervisors and training officers to give the initial training and familiarization to the duties of a new inspector in a controlled manner. US NRC inspector qualification journals have been used to define the areas of attention. This guideline provides large flexibility for application in different type organizations. Large organizations can develop separate qualification journals for each inspector positions. Small regulatory bodies can develop individual training programmes by defining the necessary training topics on case by case basis. E.g. the guideline can be used to define the qualifications of contracted inspectors used in some countries. The appropriate part would apply. Annex 1 gives two examples how this guideline could be applied.

Education and Obesity in Four OECD Countries. OECD Education Working Papers, No. 39

Science.gov (United States)

Sassi, Franco; Devaux, Marion; Church, Jody; Cecchini, Michele; Borgonovi, Francesca

2009-01-01

An epidemic of obesity has been developing in virtually all OECD countries over the last 30 years. Existing evidence provides strong suggestions that such epidemic has affected certain social groups more than others. In particular, education appears to be associated with a lower likelihood of obesity, especially among women. A range of analyses of…

The (New) OECD Jobs Study: Introduction and Assessment

OpenAIRE

Alfred Stiglbauer

2006-01-01

In 1994, the OECD presented the Jobs Study analyzing the causes of high unemployment in Europe. The study identified inappropriate labor market regulations and legislation as a key determinant of high unemployment. The OECD recommended deregulation and liberalization of labor market institutions as a remedy. Meanwhile, new empirical research has explored the influence of labor market institutions on unemployment and has only partly confirmed the recommendations of the Jobs Study. In a reevalu...

Efficient clinical evaluation of guideline quality: development and testing of a new tool

Science.gov (United States)

2014-01-01

Background Evaluating the methodological quality of clinical practice guidelines is essential before deciding which ones which could best inform policy or practice. One current method of evaluating clinical guideline quality is the research-focused AGREE II instrument. This uses 23 questions scored 1–7, arranged in six domains, which requires at least two independent testers, and uses a formulaic weighted domain scoring system. Following feedback from time-poor clinicians, policy-makers and managers that this instrument did not suit clinical need, we developed and tested a simpler, shorter, binary scored instrument (the iCAHE Guideline Quality Checklist) designed for single users. Methods Content and construct validity, inter-tester reliability and clinical utility were tested by comparing the new iCAHE Guideline Quality Checklist with the AGREE II instrument. Firstly the questions and domains in both instruments were compared. Six randomly-selected guidelines on a similar theme were then assessed by three independent testers with different experience in guideline quality assessment, using both instruments. Per guideline, weighted domain and total AGREE II scores were calculated, using the scoring rubric for three testers. Total iCAHE scores were calculated per guideline, per tester. The linear relationship between iCAHE and AGREE II scores was assessed using Pearson r correlation coefficients. Score differences between testers were assessed for the iCAHE Guideline Quality Checklist. Results There were congruent questions in each instrument in four domains (Scope & Purpose, Stakeholder involvement, Underlying evidence/Rigour, Clarity). The iCAHE and AGREE II scores were moderate to strongly correlated for the six guidelines. There was generally good agreement between testers for iCAHE scores, irrespective of their experience. The iCAHE instrument was preferred by all testers, and took significantly less time to administer than the AGREE II instrument. However

Study on the chloride migration coefficient obtained following different Rapid Chloride Migration (RCM) test guidelines

NARCIS (Netherlands)

Spiesz, P.R.; Brouwers, H.J.H.; Uzoegbo, H.C.; Schmidt, W.

2013-01-01

This work presents the differences in the available Rapid Chloride Migration (RCM) test guidelines, and their influence on the values of the chloride migration coefficients DRCM, obtained following these guidelines. It is shown that the differences between the guidelines are significant and concern

Japan and the OECD - a lesson for Romania

OpenAIRE

Iustina Luţan

2007-01-01

The Organisation for Economic Co-operation and Development (OECD) is a unique forum where the governments of 30 market democracies work together to address the economic, social and governance challenges of globalisation as well as to exploit its opportunities. One of the most important advantages of the OECD over other intergovernmental organizations or academia is the fact that the work, expertise, and know-how is transferred from a wide range of participants, like member countries, senior o...

Summary of nuclear power and fuel cycle data in OECD Member countries

International Nuclear Information System (INIS)

1983-03-01

A questionnaire on Electricity Generation, Nuclear Power and Fuel Cycle Data is distributed annually to OECD Member countries. Member countries were asked to provide, where available, various statistics for the previous calendar year (1982) and modified projections up to the year 2000. Tables 1 to 8 are based on the responses received and update the March 1982 issue. Tables 3 to 8 show the revised electricity, nuclear power and fuel cycle supply and demand projections in OECD Member countries to the year 2000. Figure 1 illustrates the contribution of the different fuel sources to the OECD's electricity generation from 1974 to 1982. Figure 2 shows the nuclear share of electricity generation in the OECD countries for 1982 and 1985. Figure 3 gives the fuel cycle supply and demand from the Tables 5, 6 and 8 in the OECD area

Overview of the OECD-Halden reactor project

International Nuclear Information System (INIS)

Vitanza, Carlo

2001-01-01

The OECD Halden Reactor Project is an international network dedicated to enhanced safety and reliability of nuclear power plants. The Project operates under the auspices of the OECD Nuclear Energy Agency and aims at addressing and resolving issues relevant to safety as they emerge in the nuclear community. This paper gives a concise presentation of the Project goals and of its technical infrastructure. The paper contains also a brief overview of results from the programme carried out in the time period 1997-1999 and of the main issues contemplated for the 3-year programme period 2000-2002

77 FR 38282 - Final Test Guidelines; OCSPP 850 Series; Notice of Availability

Science.gov (United States)

2012-06-27

... Plants, Cyanobacteria, and Terrestrial Soil Core Microcosm. Group F--Field Test Data Reporting Guidelines...'' to ``Terrestrial and Aquatic Plants, Cyanobacteria, and Terrestrial Soil Core Microcosm Test... 850.5400) and OCSPP 850.4900 ``Terrestrial Soil-Core Microcosm Test'' (Public Draft OPPTS 850.2450...

Selection of reference soils for chemicals testing in the European Community

International Nuclear Information System (INIS)

Kuhnt, G.; Hertling, T.; Schmotz, W.; Vetter, L.; Fraenzle, M.; Geissler, S.; Knabe, I.; Maass, R.; Struckmeyer, A.; Heinrich, U.

1991-01-01

Based on an multivariate statistical evaluation of binary and metric data relating to the soil cover of the European Community five regionally representative reference soils (EURO-Soils) have been identified for chemicals testing in the EC. The soil material sampled at representative localities in Italy, Greece, Great Britain, France and Germany was treated and prepared according to OECD Test Guideline 106 and analysed in detail. The homogenised specimens were subject to an EC-wide ring test to evaluate the feasibility of the modified guideline and to validate the physical-chemical amenability of the reference soils for sorption tests. The results proved the validity of the soils selected for assessing the potential behaviour of new chemicals in soil on the basis of a comparative evaluation of the individual test results obtained. In the light of this parametric assessment potential test soils were subsequently identified in the individual EC Member States which correspond as far as possible to the above reference soils in terms of both taxonomy and sorption-relevant properties. (orig.). 164 refs., 30 tabs., 24 figs [de

RELAP5/MOD2 post-test calculation of the OECD LOFT experiment LP-SB-2

International Nuclear Information System (INIS)

Perez, J.; Mendizabal, R.

1992-04-01

This document presents the analysis of the OECD LOFT LP-SB-2 Experiment performed by the Consejo de Seguridad Nuclear of Spain working group making use of RELAP5/MOD2 in the frame of the Spanish LOFT Project. LB-SB-2 experiment studies the effect of a delayed pump trip in a small break LOCA scenario with a 3-inch equivalent diameter break in the hot leg of a commercial PWR

OECD/MCCI 2-D Core Concrete Interaction (CCI) tests : final report February 28, 2006.

Energy Technology Data Exchange (ETDEWEB)

Farmer, M. T.; Lomperski, S.; Kilsdonk, D. J.; Aeschlimann, R. W.; Basu, S. (Nuclear Engineering Division); (NRC)

2011-05-23

reactor material database for dry cavity conditions is solely one-dimensional. Although the MACE Scoping Test was carried out with a two-dimensional concrete cavity, the interaction was flooded soon after ablation was initiated to investigate debris coolability. Moreover, due to the scoping nature of this test, the apparatus was minimally instrumented and therefore the results are of limited value from the code validation viewpoint. Aside from the MACE program, the COTELS test series also investigated 2-D CCI under flooded cavity conditions. However, the input power density for these tests was quite high relative to the prototypic case. Finally, the BETA test series provided valuable data on 2-D core concrete interaction under dry cavity conditions, but these tests focused on investigating the interaction of the metallic (steel) phase with concrete. Due to these limitations, there is significant uncertainty in the partition of energy dissipated for the ablation of concrete in the lateral and axial directions under dry cavity conditions for the case of a core oxide melt. Accurate knowledge of this 'power split' is important in the evaluation of the consequences of an ex-vessel severe accident; e.g., lateral erosion can undermine containment structures, while axial erosion can penetrate the basemat, leading to ground contamination and/or possible containment bypass. As a result of this uncertainty, there are still substantial differences among computer codes in the prediction of 2-D cavity erosion behavior under both wet and dry cavity conditions. In light of the above issues, the OECD-sponsored Melt Coolability and Concrete Interaction (MCCI) program was initiated at Argonne National Laboratory. The project conducted reactor materials experiments and associated analysis to achieve the following technical objectives: (1) resolve the ex-vessel debris coolability issue through a program that focused on providing both confirmatory evidence and test data for the

OECD Trilog Plenary Symposium : public policy issues in global freight logistics

Science.gov (United States)

1998-01-01

This is the fifth plenary symposium on public policy issues in global freight logistics conducted by the Organization for Economic Cooperation and Development (OECD). OECD's Trilateral Logistics Project, Trilog Project, is aimed at clarifying the pub...

OECD BEPS: Reconciling global trade, taxation principles and the digital economy

OpenAIRE

Lee-Makiyama, Hosuk; Verschelde, Bert

2014-01-01

Following media reports on the low tax rates paid by some of the world's largest multinationals, international tax reform has moved to the top of policy-makers' agendas across the world. At the request of the G20, the OECD has designed an action plan to address what it calls base erosion and profit shifting (BEPS) - namely that the corporate tax base is eroding due to the internet. However OECD itself admits there is no evidence of base erosion in reality. Nonetheless, some OECD and EU Member...

OECD, "Key Competencies" and the New Challenges of Educational Inequality

Science.gov (United States)

Takayama, Keita

2013-01-01

In this paper, I develop a critique of the Organization for Economic Cooperation and Development (OECD)-based lifelong learning policy discourse with a particular focus on "key competencies" (KCs) and its equity implications for school curricular policies. First, I review the discussion of KCs in the writings by the OECD-affiliated…

IAEA/NEA Fuel Incident Notification and Analysis System (FINAS) guidelines

International Nuclear Information System (INIS)

2006-01-01

The Fuel Incident Notification and Analysis System (FINAS) is an international system jointly operated by the International Atomic Energy Agency (IAEA) and the Nuclear Energy Agency of the Organisation for Economic Cooperation and Development (OECD/NEA). The fundamental objective of FINAS is to contribute to improving the safety of fuel cycle facilities, which are operated worldwide. This objective can be achieved by providing timely and detailed information on both technical and human factors related to events of safety significance, which occur at these facilities. The purpose of these guidelines, which supersede the previous NEA FINAS guidelines is to describe the system and to give users the necessary background and guidance to enable them to produce FINAS reports meeting a high standard of quality while retaining the high efficiency of the system expected by all Member States operating FCFs. These guidelines have been jointly developed and approved by the NEA/IAEA

Quarterly coal statistics of OECD countries

Energy Technology Data Exchange (ETDEWEB)

1992-04-27

These quarterly statistics contain data from the fourth quarter 1990 to the fourth quarter 1991. The first set of tables (A1 to A30) show trends in production, trade, stock change and apparent consumption data for OECD countries. Tables B1 to B12 show detailed statistics for some major coal trade flows to and from OECD countries and average value in US dollars. A third set of tables, C1 to C12, show average import values and indices. The trade data have been extracted or derived from national and EEC customs statistics. An introductory section summarizes trends in coal supply and consumption, deliveries to thermal power stations; electricity production and final consumption of coal and tabulates EEC and Japanese steam coal and coking coal imports to major countries.

Guidelines of the Design of Electropyrotechnic Firing Circuit for Unmanned Flight and Ground Test Projects

Science.gov (United States)

Gonzalez, Guillermo A.; Lucy, Melvin H.; Massie, Jeffrey J.

2013-01-01

The NASA Langley Research Center, Engineering Directorate, Electronic System Branch, is responsible for providing pyrotechnic support capabilities to Langley Research Center unmanned flight and ground test projects. These capabilities include device selection, procurement, testing, problem solving, firing system design, fabrication and testing; ground support equipment design, fabrication and testing; checkout procedures and procedure?s training to pyro technicians. This technical memorandum will serve as a guideline for the design, fabrication and testing of electropyrotechnic firing systems. The guidelines will discuss the entire process beginning with requirements definition and ending with development and execution.

Budget reform in Ukraine and the OECD countries

Directory of Open Access Journals (Sweden)

Puchko Anna

2016-09-01

Full Text Available The article analyzes the fiscal reforms in Ukraine and the OECD countries. It has been proved that the main areas which should undergo changes are the tax reform, regulatory reform and restructuring policies to encourage entrepreneurship, reform of social protection and social security, reform of social sphere constituents, administrative reform, reform of the army and law enforcement, administrative and territorial reform. According to the analysis results, there has been drawn the conclusion about the need to introduce in Ukraine the successful experience of the OECD countries in implementing budget reforms.

Development and construction of a specific chamber for phototoxicity test

International Nuclear Information System (INIS)

Sufi, Bianca S.; Mathor, Monica B.; Esteves-Pedro, Natalia M.; Kaneko, Telma Mary

2013-01-01

Phototoxicity corresponds to the acute toxic response induced after skin exposure 'in vivo' and 'ex vivo' to certain chemicals and subsequent exposure to irradiation. Phototoxicity 'in vitro' assay is determined by viability of fibroblasts BALB/c 3T3 exposed to chemicals in the presence and absence of light. Substances identified as phototoxic are susceptible to 'in vivo' phototoxicity (OECD 432, 2004). A chamber was developed and constructed according to the guidelines OECD Toxicity Guide - 432 and ®ECVAM DB-ALM: INVITTOX N. 78. The chamber was built in stainless steel frame, with UVA lamps and dark area for negative control. The tests to qualify the chamber were performed with Sodium Lauryl Sulfate, recommended by the guides aforementioned, as negative control; and Bergamot oil (Givaudan-Roche), as positive control. Bergamot, Citrus bergamia, has, as major component, Bergapten responsible for its photosensitive activity. Both samples were diluted in Phosphate Buffered Saline with concentrations between 0.005 and 0.1 mg/mL, which were calculated by the dilution factor 1.47. These tests were performed over fibroblast BALB/c 3T3 culture and submitted to phototoxicity assay with MTS dye, under spectrophotometric reading, which allows determining the Photo Irritation Factor (PIF), what suggests that a substance with a PIF 2 and 5 provides phototoxicity. Sodium Lauryl Sulfate presented a PIF=1, being in accordance with the OECD. Bergamot oil has shown to be likely phototoxic with a PIF=2,475. These results provide that the chamber is qualified to be used to perform phototoxicity tests with assurance and security. (author)

Inequality in OECD countries.

Science.gov (United States)

Thévenot, Celine

2017-08-01

This article recalls the state of play of inequality levels and trends in OECD countries, with a special focus on Nordic countries. It sheds light on explaining the drivers of the rise in inequality and its economic consequences. It addresses in particular the issue of redistribution through taxes and transfers. It concludes with an overview of policy packages that should be considered to address the issue of rising inequalities.

Effects of direct-to-consumer advertising and clinical guidelines on appropriate use of human papillomavirus DNA tests.

Science.gov (United States)

Price, Rebecca Anhang; Frank, Richard G; Cleary, Paul D; Goldie, Sue J

2011-02-01

Both clinical guidelines and direct-to-consumer (DTC) advertising influence the use of new health care technologies, but little is known about their relative effects. The introduction of a cervical cancer screening test in 2000 offered a unique opportunity to assess the 2 strategies. To evaluate the effects of clinical guidelines and a targeted DTC advertising campaign on overall and appropriate use of human papillomavirus (HPV) DNA tests. Quasi-experimental study using difference-in-differences analysis. Data were MarketScan private insurance claims for 500,000 women aged 21 to 64 enrolled at least 12 consecutive months from January 2001 through December 2005. Both clinical guidelines and DTC advertising were associated with increases in overall HPV DNA test use. DTC advertising was associated with a statistically significant increase in HPV DNA test use in 2 groups of DTC cities (+5.57%, P advertising was associated with comparable increases in the probability of appropriate and inappropriate use of the HPV DNA test in primary screening. Clinical guideline releases from the American College of Obstetricians and Gynecologists, and by a cosponsored panel, were associated with greater increases in HPV DNA tests for appropriate primary screening than for inappropriate primary screening (β = 0.3347, P advertising was associated with increased overall use of a cervical cancer screening test, whereas clinical guidelines were differentially associated with increased appropriate use. These findings suggest distinct influences of consumer marketing and professional guidelines on the use of health care products and services.

Regulatory ecotoxicity testing of nanomaterials – proposed modifications of OECD test guidelines based on laboratory experience with silver and titanium dioxide nanoparticles

DEFF Research Database (Denmark)

Hund-Rinke, Kerstin; Baun, Anders; Cupi, Denisa

2016-01-01

of the sediment-living worm Lumbriculus variegatus (TG 225), activity of soil microflora (TGs 216, 217), and reproduction of the invertebrates (Enchytraeus crypticus, Eisenia fetida, TGs 220, 222). Additionally, test descriptions for two further test systems (root elongation of plants in hydroponic culture; test...

The teratology testing of food additives.

Science.gov (United States)

Barrow, Paul C; Spézia, François

2013-01-01

The developmental and reproductive toxicity testing (including teratogenicity) of new foods and food additives is performed worldwide according to the guidelines given in the FDA Redbook. These studies are not required for substances that are generally recognized as safe, according to the FDA inventory. The anticipated cumulated human exposure level above which developmental or reproduction studies are required depends on the structure-alert category. For food additives of concern, both developmental (prenatal) and reproduction (multigeneration) studies are required. The developmental studies are performed in two species, usually the rat and the rabbit. The reproduction study is generally performed in the rat. The two rat studies are preferably combined into a single experimental design, if possible. The test methods described in the FDA Redbook are similar to those specified by the OECD for the reproductive toxicity testing of chemicals.

Guidelines for inservice testing at nuclear power plants

International Nuclear Information System (INIS)

Campbell, P.

1995-04-01

The staff of the U.S. Nuclear Regulatory Commission (NRC) gives licensees guidelines and recommendations for developing and implementing programs for the inservice testing of pumps and valves at commercial nuclear power plants. The staff discusses the regulations; the components to be included in an inservice testing program; and the preparation and content of cold shutdown justifications, refueling outage justifications, and requests for relief from the American Society of Mechanical Engineers Code requirements. The staff also gives specific guidance on relief acceptable to the NRC and advises licensees in the use of this information at their facilities. The staff discusses the revised standard technical specifications for the inservice testing program requirements and gives guidance on the process a licensee may follow upon finding an instance of noncompliance with the Code

Kajian Perbandingan Tax Treaty Model: OECD, UN, dan US

OpenAIRE

Rachmawati, Dyna

2003-01-01

The needs of tax treaty arise as International trade growth rapidly due to advancement of information technology. Taxa imposed on income derived from International trade are double. Tax treaty or tax convention is bilateral agreement for the avoidance of double taxation. This agreement arranges taxation rights. There are 3 (three) tax treaty model, which is used as reference to make bilateral agreement for the avoidance of double taxation. The first one is OECD Model made by The OECD...

Adults, Computers and Problem Solving: "What's the Problem?" OECD Skills Studies

Science.gov (United States)

Chung, Ji Eun; Elliott, Stuart

2015-01-01

The "OECD Skills Studies" series aims to provide a strategic approach to skills policies. It presents OECD internationally comparable indicators and policy analysis covering issues such as: quality of education and curricula; transitions from school to work; vocational education and training (VET); employment and unemployment; innovative…

Energy statistics and balances of non-OECD countries 1993-1994

International Nuclear Information System (INIS)

1996-01-01

Contains a compilation of energy supply and consumption statistics for more than 100 non-OECD countries and regions, including developing countries Central and Eastern European countries and the former USSR. Data are expressed in original units and in common units for coal, oil, gas, electricity, heat and combustible renewable and waste. Historical tables for both individual countries and regions summarize data on coal, oil, gas and electricity production, trade and consumption as well as main energy and economic indicators since 1971. Each issue includes definitions of products and flows and notes on the individual countries as well as conversion factors from original units to common energy units. Similar data for OECD are available in the IEA Energy Statistics and Energy Balances of OECD Countries. (author)

Nuclear power programmes and medium term projections in the OECD area

International Nuclear Information System (INIS)

Miida, J.; Haeussermann, W.; Mankin, S.

1977-01-01

The paper describes nuclear power growth forecasts up to 1985 on an individual country basis for the OECD area, based on present nuclear programmes. For the period between 1985 and the year 2000, no individual countries' estimates are given. The projections for this period are subdivided into three main areas: OECD Europe, North America and OECD Pacific Region. These projections are derived from the presently prevailing estimates concerning total energy growth, the increasing share of electricity requirements in total energy requirements and the growth of the nuclear share in electrical installed capacity. The basic assumptions are discussed and the combination of various possibilities results in upper and lower growth limits, which should include the most likely development. An attempt is also made to describe probable scenarios of nuclear reactor strategies, taking into account developments under way in the OECD area. Finally, the factors liable to influence nuclear power growth in a positive or negative way are briefly analysed

Effects of Direct-to-Consumer Advertising and Clinical Guidelines on Appropriate Use of Human Papillomavirus DNA Tests

Science.gov (United States)

2011-01-01

Background Both clinical guidelines and direct-to-consumer (DTC) advertising influence use of new health care technologies, but little is known about their relative effects. The introduction of a cervical cancer screening test in 2000 offered a unique opportunity to assess the two strategies. Objective To evaluate the effects of clinical guidelines and a targeted DTC advertising campaign on overall and appropriate use of human papillomavirus (HPV) DNA tests. Research Design Quasi-experimental study using difference-in-differences analysis. Data were MarketScan private insurance claims for 500,000 women ages 21 to 64 enrolled at least 12 consecutive months from January 2001 through December 2005. Results Both clinical guidelines and DTC advertising were associated with increases in overall HPV DNA test use. DTC advertising was associated with a statistically significant increase in HPV DNA test use in two groups of DTC cities (+5.57 percent, padvertising was associated with comparable increases in the probability of appropriate and inappropriate use of the HPV DNA test in primary screening. Clinical guideline releases from the American College of Obstetricians and Gynecologists, and by a co-sponsored panel, were associated with greater increases in HPV DNA tests for appropriate primary screening than for inappropriate primary screening (β=0.3347, padvertising was associated with increased overall use of a cervical cancer screening test, while clinical guidelines were differentially associated with increased appropriate use. These findings suggest distinct influences of consumer marketing and professional guidelines on the use of health care products and services. PMID:21150798

OECD/NRC Benchmark Based on NUPEC PWR Sub-channel and Bundle Test (PSBT). Volume I: Experimental Database and Final Problem Specifications

International Nuclear Information System (INIS)

Rubin, A.; Schoedel, A.; Avramova, M.; Utsuno, H.; Bajorek, S.; Velazquez-Lozada, A.

2012-01-01

The need to refine models for best-estimate calculations, based on good-quality experimental data, has been expressed in many recent meetings in the field of nuclear applications. The needs arising in this respect should not be limited to the currently available macroscopic methods but should be extended to next-generation analysis techniques that focus on more microscopic processes. One of the most valuable databases identified for the thermal-hydraulics modelling was developed by the Nuclear Power Engineering Corporation (NUPEC), Japan, which includes sub-channel void fraction and departure from nucleate boiling (DNB) measurements in a representative Pressurised Water Reactor (PWR) fuel assembly. Part of this database has been made available for this international benchmark activity entitled 'NUPEC PWR Sub-channel and Bundle Tests (PSBT) benchmark'. This international project has been officially approved by the Japanese Ministry of Economy, Trade, and Industry (METI), the US Nuclear Regulatory Commission (NRC) and endorsed by the OECD/NEA. The benchmark team has been organised based on the collaboration between Japan and the USA. A large number of international experts have agreed to participate in this programme. The fine-mesh high-quality sub-channel void fraction and departure from nucleate boiling data encourages advancement in understanding and modelling complex flow behaviour in real bundles. Considering that the present theoretical approach is relatively immature, the benchmark specification is designed so that it will systematically assess and compare the participants' analytical models on the prediction of detailed void distributions and DNB. The development of truly mechanistic models for DNB prediction is currently underway. The benchmark problem includes both macroscopic and microscopic measurement data. In this context, the sub-channel grade void fraction data are regarded as the macroscopic data and the digitised computer graphic images are the

Current status of developmental neurotoxicity: regulatory view

DEFF Research Database (Denmark)

Hass, Ulla

2003-01-01

in the testing strategy for new and existing substances, and biocides. Hopefully, this will lead to an improved database for risk assessment of potential developmental neurotoxicants. However, the regulatory authorities and toxicologists will also be faced with the challenge that decisions have to be made......The need for developmental neurotoxicity testing has been recognized for decades and guidelines are available, as the USEPA guideline and the OECD draft TG 426. Regulatory testing of industrial chemicals for developmental neurotoxicity is required to some extent, especially for pesticides in the US....... Until recently, however, developmental neurotoxicity testing of industrial chemicals has not been a clear regulatory requirement in EU, probably due to the lack of an accepted OECD TG. The revised EU Technical Guidance Document for Risk Assessment (EU-TGD) has now included the OECD draft TG 426...

Evaluating compliance with institutional preoperative testing guidelines for minimal-risk patients undergoing elective surgery.

Science.gov (United States)

Siriussawakul, Arunotai; Nimmannit, Akarin; Rattana-arpa, Sirirat; Chatrattanakulchai, Siritda; Saengtawan, Puttachard; Wangdee, Aungsumat

2013-01-01

Few investigations preoperatively are important for low-risk patients. This study was designed to determine the level of compliance with preoperative investigation guidelines for ASA I patients undergoing elective surgery. Secondary objectives included the following: to identify common inappropriate investigations, to evaluate the impact of abnormal testing on patient management, to determine factors affecting noncompliant tests, and to estimate unnecessary expenditure. This retrospective study was conducted on adult patients over a one-year period. The institute's guidelines recommend tests according to the patients' age groups: a complete blood count (CBC) for those patients aged 18-45; CBC, chest radiograph (CXR) and electrocardiography (ECG) for those aged 46-60; and CBC, CXR, ECG, electrolytes, blood glucose, blood urea nitrogen (BUN), and creatinine (Cr) for patients aged 61-65. The medical records of 1,496 patients were reviewed. Compliant testing was found in only 12.1% (95% CI, 10.5-13.9). BUN and Cr testings were the most frequently overprescribed tests. Overinvestigations tended to be performed on major surgery and younger patients. Overall, overinvestigation incurred an estimated cost of US 200,000 dollars during the study period. The need to utilize the institution's preoperative guidelines should be emphasized in order to decrease unnecessary testing and the consequential financial burden.

Nuclear fuel behavior activities at the OECD/NEA

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-12-01

The work programme regarding nuclear fuel behavior issues at OECD/NEA is carried out in two sections. The Nuclear Science and Data Bank Division deals with basic phenomena in fuel behavior under normal operating conditions, while the Safety Division concentrates upon regulation and safety issues in fuel behavior. A new task force addressing these latter issues has been set up and will produce a report providing recommendations in this field. The OECD Nuclear Energy Agency jointly with the International Atomic Energy Agency established an International Fuel Performance Experiments Database which is operated by the NEA Data Bank. (author). 1 tab.

Nuclear fuel behavior activities at the OECD/NEA

International Nuclear Information System (INIS)

1997-01-01

The work programme regarding nuclear fuel behavior issues at OECD/NEA is carried out in two sections. The Nuclear Science and Data Bank Division deals with basic phenomena in fuel behavior under normal operating conditions, while the Safety Division concentrates upon regulation and safety issues in fuel behavior. A new task force addressing these latter issues has been set up and will produce a report providing recommendations in this field. The OECD Nuclear Energy Agency jointly with the International Atomic Energy Agency established an International Fuel Performance Experiments Database which is operated by the NEA Data Bank. (author). 1 tab

The OECD and the Expansion of PISA: New Global Modes of Governance in Education

Science.gov (United States)

Sellar, Sam; Lingard, Bob

2014-01-01

This paper examines the expansion of the OECD's Programme for International Student Assessment (PISA) and associated growth in the influence of the OECD's education work. PISA has become one of the OECD's most successful "products" and has both strengthened the role of the Directorate for Education within the organization and enhanced…

ASVCP quality assurance guidelines: external quality assessment and comparative testing for reference and in-clinic laboratories.

Science.gov (United States)

Camus, Melinda S; Flatland, Bente; Freeman, Kathleen P; Cruz Cardona, Janice A

2015-12-01

The purpose of this document is to educate providers of veterinary laboratory diagnostic testing in any setting about comparative testing. These guidelines will define, explain, and illustrate the importance of a multi-faceted laboratory quality management program which includes comparative testing. The guidelines will provide suggestions for implementation of such testing, including which samples should be tested, frequency of testing, and recommendations for result interpretation. Examples and a list of vendors and manufacturers supplying control materials and services to veterinary laboratories are also included. © 2015 American Society for Veterinary Clinical Pathology.

Modelling guidelines for core exit temperature simulations with system codes

Energy Technology Data Exchange (ETDEWEB)

Freixa, J., E-mail: jordi.freixa-terradas@upc.edu [Department of Physics and Nuclear Engineering, Technical University of Catalonia (UPC) (Spain); Paul Scherrer Institut (PSI), 5232 Villigen (Switzerland); Martínez-Quiroga, V., E-mail: victor.martinez@nortuen.com [Department of Physics and Nuclear Engineering, Technical University of Catalonia (UPC) (Spain); Zerkak, O., E-mail: omar.zerkak@psi.ch [Paul Scherrer Institut (PSI), 5232 Villigen (Switzerland); Reventós, F., E-mail: francesc.reventos@upc.edu [Department of Physics and Nuclear Engineering, Technical University of Catalonia (UPC) (Spain)

2015-05-15

Highlights: • Core exit temperature is used in PWRs as an indication of core heat up. • Modelling guidelines of CET response with system codes. • Modelling of heat transfer processes in the core and UP regions. - Abstract: Core exit temperature (CET) measurements play an important role in the sequence of actions under accidental conditions in pressurized water reactors (PWR). Given the difficulties in placing measurements in the core region, CET readings are used as criterion for the initiation of accident management (AM) procedures because they can indicate a core heat up scenario. However, the CET responses have some limitation in detecting inadequate core cooling and core uncovery simply because the measurement is not placed inside the core. Therefore, it is of main importance in the field of nuclear safety for PWR power plants to assess the capabilities of system codes for simulating the relation between the CET and the peak cladding temperature (PCT). The work presented in this paper intends to address this open question by making use of experimental work at integral test facilities (ITF) where experiments related to the evolution of the CET and the PCT during transient conditions have been carried out. In particular, simulations of two experiments performed at the ROSA/LSTF and PKL facilities are presented. The two experiments are part of a counterpart exercise between the OECD/NEA ROSA-2 and OECD/NEA PKL-2 projects. The simulations are used to derive guidelines in how to correctly reproduce the CET response during a core heat up scenario. Three aspects have been identified to be of main importance: (1) the need for a 3-dimensional representation of the core and Upper Plenum (UP) regions in order to model the heterogeneity of the power zones and axial areas, (2) the detailed representation of the active and passive heat structures, and (3) the use of simulated thermocouples instead of steam temperatures to represent the CET readings.

Procedures for initiation, cost-sharing and management of OECD projects in nuclear safety

International Nuclear Information System (INIS)

2002-01-01

The OECD (CSNI) projects aim to produce results relevant for the safe operation of nuclear power plants through international collaborative projects. In general, the projects consist of advanced experimental programmes that are conducted at specialized facilities. At present, the following OECD (CSNI) projects are in operation: - The Halden Project, covering fuel/materials and I and C/Human Factors issues; - The Cabri Project, addressing reactivity transients on high burnup fuels; - The MASCA Project, which deals with in-vessel corium phenomena; - The OLHF Project, dealing with lower head failure mechanisms; - The SETH Project addressing thermal-hydraulics issues, started in 2001; - The MCCI Project on ex-vessel coolability and melt-concrete interaction. There are significant differences among these projects in terms of their motivation, size and scope. The Halden Project and the Cabri Water Loop Project are large undertakings where the host organisations assume full and direct responsibility for the project establishment and administration - as well as for the negotiation with relevant parties on the terms of participation. In the other cases, instead, the NEA secretariat has a more direct responsibility, conferred by the CSNI, in establishing the project technical and financial basis, as well as for its implementation and administration. The objective of this procedure is to provide a common basis for the establishment and management of the OECD projects in the area of nuclear safety. It is a follow-up of a recommendation expressed by the CSNI Bureau during its meeting in October 2001, where the procedures for the establishment and management of the OECD (CSNI) projects in nuclear safety were addressed. While this procedure attempts at defining general guidelines for project initiation, financing and management, one should bear in mind that each project has its own motivation, background and framework. Thus, some degree of flexibility in project structure

Resource recovery and recycling in OECD countries

Energy Technology Data Exchange (ETDEWEB)

MacNeil, J.W.

It was the importance of the economic issues relevant to resource recovery and re-use that prompted OECD to become involved in this general area, and the author proposes in this talk to describe the principal features of the three main approaches to waste management from an economic perspective. These approaches are reduction of waste generation (i.e. birth control) resource recovery and materials recycling or re-use (reincarnation). Most of OECD's work in this area to date has been on the third of these approaches with particular emphasis on the economics of recycling, so somewhat more attention will be devoted to it. Then some conclusions will be drawn concerning possible policy actions to encourage a rational approach to management of this resource.

OECD Halden reactor project

International Nuclear Information System (INIS)

1978-01-01

This report summarizes the activities of the OECD Halden Reactor Project for the year 1976. The main items reported on are: a) the process supervision and control which have focused on core monitoring and control, and operator-process communication; b) the fuel performance and safety behavior which have provided data and analytical descriptions of the thermal, mechanical and chemical behavior of fuel under various operating conditions; c) the reactor operations and d) the administration and finance

The third phase of the OECD/NEA TDB project: TDB III

International Nuclear Information System (INIS)

Mompean, F.J.; Illemassene, M.; Perrone, J.

2005-01-01

In 2003 with a foreseen duration of four years. The main objective of this new phase is to extend the existing critically reviewed database for elements of relevance in radioactive waste management, paying attention to the needs of the various national programmes. Following the decision by the Project Management Board (integrated by representatives of 16 organisations with responsibilities in radioactive waste management in 12 OECD member countries) the elements contemplated in this new phase are Th, Sn and Fe, with a higher priority being allocated to inorganic species and compounds. In addition to the corresponding review teams for these elements, an additional expert team has been constituted to prepare guidelines for the evaluation of thermodynamic data for solid solutions. As was the case in TDB Phase II, the basic project review methodology remains unaltered in TDB III. The Figure illustrates the relationship between the various TDB bodies, with an International Organisation, the OECD NEA, acting as Project Coordinator and linking the independent scientific teams and the project governing bodies. This organizational paradigm has proven successful with the recent completion of the five Phase II Reviews (Update, Ni, Se, Zr and Organic Ligands). The review and expert team activities were started in 2004 (except for Fe, being started in 2005) following an initiation stage. This preliminary stage was designed in order to tailor the team compositions to the existing literature for each element. The first reviews stemming from TDB III are scheduled to appear in published form in 2007. The successful completion of these objectives will add three further reports to the current series of nine volumes (dealing with the chemical thermodynamics of U, Np, Pu, Am, Tc, Ni, Se, Zr and compounds and complexes of these elements with oxalate, citrate, EDTA and isa). (authors)

OECD - Majandusliku Koostöö ja Arengu Organisatsioon / Kairi Saar, Jane Makke

Index Scriptorium Estoniae

Saar, Kairi, 1973-

2011-01-01

Ülevaade OECD ajaloost, tegevusest, liikmesuse kriteeriumitest (riikide sarnane mõtteviis) ning majandusprognoose, uuringuid ja statistikat sisaldavatest väljaannetest. Eesti liitumisest organisatsiooniga 2010. a., Eesti ja Balti riikide kohta avaldatud väljaanded. Rahvusraamatukogu kui OECD hoiuraamatukogu Eestis

Investigation of two widely used nanomaterials (TiO{sub 2}, Ag) for ecotoxicological long-term effects. Adaption of test guidelines

Energy Technology Data Exchange (ETDEWEB)

Schaefers, Christoph [Fraunhofer-Institut fuer Molekularbiologie und Angewandte Oekologie (IME), Schmallenberg (Germany); Weil, Mirco [ECT Oekotoxikologie GmbH, Floersheim (Germany)

2013-03-15

The nanoparticulate titanium dioxide NM-105 was investigated with Lumbriculus variegatus in a sediment- water system according to OECD TG 225. Test media were prepared by dilution of NM-105-suspensions with the sediment-overlying water. Nominal test concentrations (confirmed by chemical analysis of Ti conc. in test media) were 15; 23; 39; 63 and 100 mg NM-105/L. No adverse effects on reproduction or biomass of the worms were observed. The NOEC {>=} 100 mg/L was confirmed in a second test with 100 mg NM-105/L. At test end, Ti conc. in worms were similar in all treatments. Additionally, NM-105 was investigated in OECD TG 226 tests with the predatory mite Hypoaspis aculeifer. Test substrates were prepared by mixing the solid powder into artificial soil (test conc. {>=} 10mg/kg) or application of NM-105-suspensions ({<=} 10mg/kg). For 10 mg/kg, no influence of the application method on the endpoints was observed. No significant effect of the treatments 1; 10; 100; 1000 mg NM-105/kg artificial soil (dw) was detected in the 1{sup st} definitive test, the 2{sup nd} test at 1 and 1000 mg NM-105/kg showed significantly lower numbers of juvenile mites compared to the control in both treatments due to higher statistical power of the doubled number of replicates. For the standard design, which was proven to be applicable to the testing of nanomaterials, the NOEC was {>=} 1000 mg NM-105/kg. The nanoparticulate silver NM-300 K was investigated in two fish early life stage toxicity tests (OECD TG 210) with Danio rerio in a 250 L static system. The NM-300 K dispersion (1:10) was slightly diluted, ultra-sonificated and directly applied to the test vessels. The water in all test aquaria was constantly moved by four pumps each for homogeneous distribution and minimized sedimentation. Every 7 days, the test medium was exchanged. The nominal test concentrations were 12.5; 25; 50; 100 and 200 {mu}g Ag/L in the 1{sup st} test and 12.5; 50; 100 {mu}g/L in the 2{sup nd} test. Chemical

Explaining convergence of oecd welfare states

DEFF Research Database (Denmark)

Schmitt, C.; Starke, Peter

2011-01-01

of conditional convergence helps to both better describe and explain the phenomenon. By applying error correction models, we examine conditional convergence of various types of social expenditure in 21 OECD countries between 1980 and 2005. Our empirical findings go beyond the existing literature in two respects...

Evaluating Compliance with Institutional Preoperative Testing Guidelines for Minimal-Risk Patients Undergoing Elective Surgery

Directory of Open Access Journals (Sweden)

Arunotai Siriussawakul

2013-01-01

Full Text Available Background. Few investigations preoperatively are important for low-risk patients. This study was designed to determine the level of compliance with preoperative investigation guidelines for ASA I patients undergoing elective surgery. Secondary objectives included the following: to identify common inappropriate investigations, to evaluate the impact of abnormal testing on patient management, to determine factors affecting noncompliant tests, and to estimate unnecessary expenditure. Methods. This retrospective study was conducted on adult patients over a one-year period. The institute’s guidelines recommend tests according to the patients’ age groups: a complete blood count (CBC for those patients aged 18–45; CBC, chest radiograph (CXR and electrocardiography (ECG for those aged 46–60; and CBC, CXR, ECG, electrolytes, blood glucose, blood urea nitrogen (BUN, and creatinine (Cr for patients aged 61–65. Results. The medical records of 1,496 patients were reviewed. Compliant testing was found in only 12.1% (95% CI, 10.5–13.9. BUN and Cr testings were the most frequently overprescribed tests. Overinvestigations tended to be performed on major surgery and younger patients. Overall, overinvestigation incurred an estimated cost of US 200,000 dollars during the study period. Conclusions. The need to utilize the institution’s preoperative guidelines should be emphasized in order to decrease unnecessary testing and the consequential financial burden.

SFC/SFBMN guidelines update for nuclear cardiology procedures: stress testing in adults and children

International Nuclear Information System (INIS)

Manrique, A.; Marie, P.Y.; Maunoury, Ch.; Acar, Ph.; Agostini, D.

2002-01-01

The guidelines update for nuclear cardiology procedures are studied in this article. We find the minimum technique conditions for the stress testing practice, the recommendations for the different ischemia activation tests, the choice of the stress test. (N.C.)

Development and construction of a specific chamber for phototoxicity test

Energy Technology Data Exchange (ETDEWEB)

Sufi, Bianca S.; Mathor, Monica B., E-mail: biancasufi@usp.br, E-mail: mathor@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Esteves-Pedro, Natalia M.; Kaneko, Telma Mary, E-mail: nataliamenves@yahoo.com.br, E-mail: tsakuda@usp.br [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). Fac. de Ciencias Farmaceuticas; Lopes, Patricia, E-mail: patricia.lopes@unifesp.br [Universidade Federal de Sao Paulo (UNIFESP), Diadema, SP (Brazil)

2013-07-01

Phototoxicity corresponds to the acute toxic response induced after skin exposure 'in vivo' and 'ex vivo' to certain chemicals and subsequent exposure to irradiation. Phototoxicity 'in vitro' assay is determined by viability of fibroblasts BALB/c 3T3 exposed to chemicals in the presence and absence of light. Substances identified as phototoxic are susceptible to 'in vivo' phototoxicity (OECD 432, 2004). A chamber was developed and constructed according to the guidelines OECD Toxicity Guide - 432 and ®ECVAM DB-ALM: INVITTOX N. 78. The chamber was built in stainless steel frame, with UVA lamps and dark area for negative control. The tests to qualify the chamber were performed with Sodium Lauryl Sulfate, recommended by the guides aforementioned, as negative control; and Bergamot oil (Givaudan-Roche), as positive control. Bergamot, Citrus bergamia, has, as major component, Bergapten responsible for its photosensitive activity. Both samples were diluted in Phosphate Buffered Saline with concentrations between 0.005 and 0.1 mg/mL, which were calculated by the dilution factor 1.47. These tests were performed over fibroblast BALB/c 3T3 culture and submitted to phototoxicity assay with MTS dye, under spectrophotometric reading, which allows determining the Photo Irritation Factor (PIF), what suggests that a substance with a PIF<2 predicts no phototoxicity; PIF>2 and <5 provides likely phototoxicity and PIF>5 provides phototoxicity. Sodium Lauryl Sulfate presented a PIF=1, being in accordance with the OECD. Bergamot oil has shown to be likely phototoxic with a PIF=2,475. These results provide that the chamber is qualified to be used to perform phototoxicity tests with assurance and security. (author)

An OECD perspective of the role of risk assessment in policy development

Energy Technology Data Exchange (ETDEWEB)

Brydon, Jim [Environmental Health and Safety Division, Organization for Economic Co-operation and Development, Paris (France)

1992-07-01

OECD is an intergovernmental organization bringing together 24 industrialised countries from North America, Western Europe, and the Pacific. Its basic aims include the following: - to achieve high sustainable development, economic growth and employment; - to achieve high economic and social welfare and a high standard of living throughout the OECD area and in non-Member countries: The specialised Agencies and Directorates of OECD cover the full breadth of economic and social activities of concern to the Conference. Under their programmes, there are a variety of activities which involve various elements of qualitative and quantitative risk assessment. Risk assessment methodology, policies options regarding the use of risk assessment, the role of risk assessment in policy and decision-making are all routine in OECD work. This work ranges from, for example, work on the economics of investment policies, through work on food safety, to the analysis of nuclear safety technology.

An OECD perspective of the role of risk assessment in policy development

International Nuclear Information System (INIS)

Brydon, Jim

1992-01-01

OECD is an intergovernmental organization bringing together 24 industrialised countries from North America, Western Europe, and the Pacific. Its basic aims include the following: - to achieve high sustainable development, economic growth and employment; - to achieve high economic and social welfare and a high standard of living throughout the OECD area and in non-Member countries: The specialised Agencies and Directorates of OECD cover the full breadth of economic and social activities of concern to the Conference. Under their programmes, there are a variety of activities which involve various elements of qualitative and quantitative risk assessment. Risk assessment methodology, policies options regarding the use of risk assessment, the role of risk assessment in policy and decision-making are all routine in OECD work. This work ranges from, for example, work on the economics of investment policies, through work on food safety, to the analysis of nuclear safety technology

MACROECONOMIC DETERMINANTS OF TOTAL FACTOR PRODUCTIVITY: NEW GENERATION PANEL DATA ANALYSIS ON OECD COUNTRIES (1996-2015

Directory of Open Access Journals (Sweden)

ÖMER YALÇINKAYA

2016-12-01

Full Text Available Determining the factors which are effective on total factor productivity (TFP increments include the productivity of all factors in the production process and making improvements for these factors via policies have importance concerning speed the potential growth rate up in the long term and making this sustainable. The mediumlong term determinants of TFP are examined in this research for the 1994-2015 period as econometric within the scope of new generation panel data analysis on the OECD countries who are classified as OECD-1 and OECD-2 by their income levels. From this aspect, purposed in this research that to reveal the primary determinants which cause the differentiations between OECD-1 and OECD-2 countries in terms of their long-term economic growth performances and/or income levels. Determined as a result of the research that the effect of the variables which are used to determine the medium-long term determinants of the TFP on OECD-1 and OECD-2 groups parallelly increased and decreased as long as enhancing the representation degree of the knowledge, innovation and technological development level of the variables. These results show that the differentiation of countries in OECD-1 and OECD-2 groups in terms of long-term economic growth and/or income levels is majorly rooted in indicators which are used on behalf of knowledge, innovation, and technological development.

TRAC-PF1 MOD1 post test calculations of the OECD LOFT Experiment LP-SB-1

International Nuclear Information System (INIS)

Allen, E.J.

1990-04-01

Analysis of the small, hot leg break, OECD LOFT Experiment LP-SB-1. using the ''best-estimate'' computer code TRAC-PF1/MOD1 is presented. Descriptions of the LOFT facility and the LP-SB-1 experiment are given and development of the TRAC-PF1/MOD1 input model is detailed. The calculations performed in achieving the steady state conditions, from which the experiment was initiated, and the specification of experimental boundary conditions are outlined. 24 refs., 66 figs., 12 tabs

Fiscal Rules and the Composition of Government Expenditures in OECD Countries

Science.gov (United States)

Dahan, Momi; Strawczynski, Michel

2013-01-01

Since the 1990s many OECD countries have adopted fiscal rules. After the adoption of these rules, the ratio of social transfers to government consumption substantially declined, and it recovered following the global economic crisis. Using a sample of 22 OECD countries, we found a negative effect of fiscal rules on the ratio of social transfers to…

Implementation of the OECD principles of good laboratory practice in test facilities complying with a quality system accredited to the ISO/IEC 17025 standard.

Science.gov (United States)

Feller, Etty

2008-01-01

Laboratories with a quality system accredited to the ISO/IEC 17025 standard have a definite advantage, compared to non-accredited laboratories, when preparing their facilities for the implementation of the principles of good laboratory practice (GLP) of the Organisation for Economic Co-operation and Development (OECD). Accredited laboratories have an established quality system covering the administrative and technical issues specified in the standard. The similarities and differences between the ISO/IEC 17025 standard and the OECD principles of GLP are compared and discussed.

Optimizing the design of a reproduction toxicity test with the pond snail Lymnaea stagnalis

DEFF Research Database (Denmark)

Charles, Sandrine; Ducrot, Virginie; Azam, Didier

2016-01-01

This paper presents the results from two ring-tests addressing the feasibility, robustness and reproducibility of a reproduction toxicity test with the freshwater gastropod Lymnaea stagnalis (RENILYS strain). Sixteen laboratories (from inexperienced to expert laboratories in mollusc testing) from...... nine countries participated in these ring-tests. Survival and reproduction were evaluated in L. stagnalis exposed to cadmium, tributyltin, prochloraz and trenbolone according to an OECD draft Test Guideline. In total, 49 datasets were analysed to assess the practicability of the proposed experimental...... protocol, and to estimate the between-laboratory reproducibility of toxicity endpoint values. The statistical analysis of count data (number of clutches or eggs per individual-day) leading to ECx estimation was specifically developed and automated through a free web-interface. Based on a complementary...

OECD migration, welfare and skill selectivity

DEFF Research Database (Denmark)

Pedersen, Peder; Pytlikova, Mariola; Smith, Nina

into 27 OECD countries over the period of 12 years, 1989-2000. Using a fixed effects panel data model, we analyze the determinants of the migration flows during the latest decade. We study whether there are significant selectivity effects in international migration flows, i.e. whether the countries...

77 FR 58665 - Significant New Use Rules on Certain Chemical Substances

Science.gov (United States)

2012-09-21

... Guideline 415); a reproduction and fertility effects test (OECD Test Guideline 416); a reproduction... potentially exposed employees wear specified respirators unless actual measurements of the workplace air show that air-borne concentrations of the PMN substance are below a New Chemical Exposure Limit (NCEL) that...

Chernobyl and the safety of nuclear reactors in OECD countries

International Nuclear Information System (INIS)

1987-01-01

This report assesses the possible bearing of the Chernobyl accident on the safety of nuclear reactors in OECD countries. It discusses analyses of the accident performed in several countries as well as improvements to the safety of RBMK reactors announced by the USSR. Several remaining questions are identified. The report compares RBMK safety features with those of commercial reactors in OECD countries and evaluates a number of issues raised by the Chernobyl accident

Labor market deregulation and globalization: empirical evidence from OECD countries

OpenAIRE

Potrafke , Niklas

2010-01-01

Abstract This paper empirically investigates the influence of globalization on various aspects of labor market deregulation. I employ the data set by Bassanini and Duval (2006) on labor market institutions in OECD countries and the KOF index of globalization. The data set covers 20 OECD countries in the 1982?2003 period. The results suggest that globalization did neither influence the unemployment replacement rate, the unemployment benefit length, public expenditures on ALMP, the t...

Adjusting health expenditure for military spending and interest payment: Israel and the OECD countries.

Science.gov (United States)

Shmueli, Amir; Israeli, Avi

2013-02-20

Compared to OECD countries, Israel has a remarkably low percentage of GDP and of government expenditure spent on health, which are not reflected in worse national outcomes. Israel is also characterized by a relatively high share of GDP spent on security expenses and payment of public debt. To determine to what extent differences between Israel and the OECD countries in security expenses and payment of the public debt might account for the gaps in the percentage of GDP and of government expenditures spent on health. We compare the percentages of GDP and of government expenditures spent on health in the OECD countries with the respective percentages when using primary civilian GDP and government expenditures (i.e., when security expenses and interest payment are deducted). We compared Israel with the OECD average and examined the ranking of the OECD countries under the two measures over time. While as a percentage of GDP, the national expenditure on health in Israel was well below the average of the OECD countries, as a percentage of primary civilian GDP it was above the average until 2003 and below the average thereafter. When the OECD countries were ranked according to decreasing percent of GDP and of government expenditure spent on health, adjusting for security and debt payment expenditures changed the Israeli rank from 23rd to 17th and from 27th to 25th, respectively. Adjusting for security expenditures and interest payment, Israel's low spending on health as a percentage of GDP and as a percentage of government's spending increases and is closer to the OECD average. Further analysis should explore the effect of additional population and macroeconomic differences on the remaining gaps.

Budgeting and Accounting in OECD Education Systems: A Literature Review. OECD Education Working Papers, No. 128

Science.gov (United States)

Fakharzadeh, Tala

2016-01-01

Recent demographic, economic and political trends have drawn attention to the issue of effectiveness and efficiency in the use of resources in the education sector. In the context of the renewed interest for the optimisation of resource use, this paper attempts to review the literature on budgeting and accounting in OECD education systems. The…

NASA Electronic Parts and Packaging Field Programmable Gate Array Single Event Effects Test Guideline Update

Science.gov (United States)

Berg, Melanie D.; LaBel, Kenneth A.

2018-01-01

The following are updated or new subjects added to the FPGA SEE Test Guidelines manual: academic versus mission specific device evaluation, single event latch-up (SEL) test and analysis, SEE response visibility enhancement during radiation testing, mitigation evaluation (embedded and user-implemented), unreliable design and its affects to SEE Data, testing flushable architectures versus non-flushable architectures, intellectual property core (IP Core) test and evaluation (addresses embedded and user-inserted), heavy-ion energy and linear energy transfer (LET) selection, proton versus heavy-ion testing, fault injection, mean fluence to failure analysis, and mission specific system-level single event upset (SEU) response prediction. Most sections within the guidelines manual provide information regarding best practices for test structure and test system development. The scope of this manual addresses academic versus mission specific device evaluation and visibility enhancement in IP Core testing.

Generic testability and test methods guidelines for ASIC devices

International Nuclear Information System (INIS)

Puri, K.; Takeda, H.

1996-04-01

Many industries are switching from analog equipment to digital equipment. This change has become desirable because digital devices have become cost-effective, easily available, highly reliable, easy to qualify and easy to test and replace when needed. The nuclear power industry is beginning to upgrade some of its instrumentation and control equipment from an analog design to digital design. A digital application specific integrated circuit (ASIC) device can be designed to perform the same functions as performed by analog modules. However, the ASIC must be designed for cost-effective testability and qualification. This report provides generic guidelines for designing cost-effective methods for testing and characterizing ASIC devices to accomplish qualification

Report: new guidelines for characterization of municipal solid waste: the Portuguese case.

Science.gov (United States)

da Graça Madeira Martinho, Maria; Silveira, Ana Isabel; Fernandes Duarte Branco, Elsa Maria

2008-10-01

This report proposes a new set of guidelines for the characterization of municipal solid waste. It is based on an analysis of reference methodologies, used internationally, and a case study of Valorsul (a company that handles recovery and treatment of solid waste in the North Lisbon Metropolitan Area). In particular, the suggested guidelines present a new definition of the waste to be analysed, change the sampling unit and establish statistical standards for the results obtained. In these new guidelines, the sampling level is the waste collection vehicle and contamination and moisture are taken into consideration. Finally, focus is on the quality of the resulting data, which is essential for comparability of data between countries. These new guidelines may also be applicable outside Portugal because the methodology includes, besides municipal mixed waste, separately collected fractions of municipal waste. They are a response to the need for information concerning Portugal (e.g. Eurostat or OECD inquiries) and follow European Union municipal solid waste management policies (e.g. packaging waste recovery and recycling targets and the reduction of biodegradable waste going to landfill).

Cabri - water loop a new IPSN-OECD international research program

International Nuclear Information System (INIS)

Anon.

2001-01-01

In 1993, the Institut de Protection et de Surete Nucleaire (IPSN, the French Nuclear Safety and Radiation Protection Institute) working with EDF (electric utilities) and backed by the NRC (Nuclear Regulatory Commission, USA) launched a research program, dubbed Cabri REP Na addressing uranium oxide-based fuels and MOX fuels. So far twelve tests have been conducted including eight on UO 2 fuel and four on MOX fuel. More testing is now required to determine fuel performance at higher specific burn-up levels in typical PWR (Pressurized Water Reactor) conditions, the purpose being to determine the acceptance criteria for tomorrow's fuels. IPSN has defined a new research program for the Cabri reactor. The OECD's Nuclear Energy Agency is quarterbacking the international program called 'Cabri-Water Loop'. (authors)

The JRC Nanomaterials Repository: A unique facility providing representative test materials for nanoEHS research.

Science.gov (United States)

Totaro, Sara; Cotogno, Giulio; Rasmussen, Kirsten; Pianella, Francesca; Roncaglia, Marco; Olsson, Heidi; Riego Sintes, Juan M; Crutzen, Hugues P

2016-11-01

The European Commission has established a Nanomaterials Repository that hosts industrially manufactured nanomaterials that are distributed world-wide for safety testing of nanomaterials. In a first instance these materials were tested in the OECD Testing Programme. They have then also been tested in several EU funded research projects. The JRC Repository of Nanomaterials has thus developed into serving the global scientific community active in the nanoEHS (regulatory) research. The unique Repository facility is a state-of-the-art installation that allows customised sub-sampling under the safest possible conditions, with traceable final sample vials distributed world-wide for research purposes. This paper describes the design of the Repository to perform a semi-automated subsampling procedure, offering high degree of flexibility and precision in the preparation of NM vials for customers, while guaranteeing the safety of the operators, and environmental protection. The JRC nanomaterials are representative for part of the world NMs market. Their wide use world-wide facilitates the generation of comparable and reliable experimental results and datasets in (regulatory) research by the scientific community, ultimately supporting the further development of the OECD regulatory test guidelines. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Proceedings of the Guidelines for Seismometer Testing Workshop, Albuquerque, New Mexico, 9-10 May 2005 ("GST2")

Science.gov (United States)

Hutt, Charles R.; Nigbor, Robert L.; Evans, John R.

2009-01-01

Testing and specification of seismic and earthquake-engineering sensors and recorders has been marked by significant variations in procedures and selected parameters. These variations cause difficulty in comparing such specifications and test results. In July 1989, and again in May 2005, the U.S. Geological Survey hosted international public/private workshops with the goal of defining widely accepted guidelines for the testing of seismological inertial sensors, seismometers, and accelerometers. This document reports the Proceedings of the 2005 workshop and includes as Appendix 6 the report of the 1989 workshop. In a future document, we will attempt to collate and rationalize a single set of formal guidelines for testing and specifying seismic sensors, supplementing Advanced National Seismic System (ANSS) guidelines on instrumentation likely used by ANSS as its standard for verification, acceptance, and intermittent testing, as well as for responses to ANSS instrument requisitions.

Private Returns to Tertiary Education - How Does New Zealand Compare to the OECD?

OpenAIRE

James Zuccollo; Sholeh Maani; Bill Kaye-Blake; Lulu Zeng

2013-01-01

How do private returns to tertiary education in New Zealand compare internationally? According to the latest OECD measures, the private rate of return for New Zealand is 8.9%, compared to an OECD average of 12.4%, placing New Zealand toward the bottom of the OECD ranking. The aim of this study is to better understand the reasons for that gap and determine whether the low returns could be considered as problems amenable to policy interventions. We identify a number of measurement issues with t...

Status of NRC approval of EPRI electromagnetic interference susceptibility testing guidelines for digital equipment

International Nuclear Information System (INIS)

James, R.W.; Shank, J.W.; Yoder, C.

1996-01-01

Historically, nuclear power plants installing digital equipment have been required to conduct expensive, site-specific electromagnetic interference (EMI) surveys to demonstrate that EMI will not affect the operation of sensitive electronic equipment. Consequently, EPRI formed a Utility Working Group which developed a set of generic EMI susceptibility testing guidelines, which were published as an EPRI report in September 1994. These guidelines are based upon EMI survey data obtained from several different plants and include criteria for determining their applicability. The Working Group interacted with NRC staff to obtain NRC approval. In April 1996, the NRC issued a Safety Evaluation Report (SER) endorsing the guidelines as a valid means of demonstrating EMI compatibility. The issuance of this SER was conditional on issuing a revision to the EPRI EMI Guidelines. This paper summarizes the guidelines, the NRC SER, and the current status of Revision 1 to the report

Adjusting health expenditure for military spending and interest payment: Israel and the OECD countries

Directory of Open Access Journals (Sweden)

Shmueli Amir

2013-02-01

Full Text Available Abstract Background Compared to OECD countries, Israel has a remarkably low percentage of GDP and of government expenditure spent on health, which are not reflected in worse national outcomes. Israel is also characterized by a relatively high share of GDP spent on security expenses and payment of public debt. Objectives To determine to what extent differences between Israel and the OECD countries in security expenses and payment of the public debt might account for the gaps in the percentage of GDP and of government expenditures spent on health. Methods We compare the percentages of GDP and of government expenditures spent on health in the OECD countries with the respective percentages when using primary civilian GDP and government expenditures (i.e., when security expenses and interest payment are deducted. We compared Israel with the OECD average and examined the ranking of the OECD countries under the two measures over time. Results While as a percentage of GDP, the national expenditure on health in Israel was well below the average of the OECD countries, as a percentage of primary civilian GDP it was above the average until 2003 and below the average thereafter. When the OECD countries were ranked according to decreasing percent of GDP and of government expenditure spent on health, adjusting for security and debt payment expenditures changed the Israeli rank from 23rd to 17th and from 27th to 25th, respectively. Conclusions Adjusting for security expenditures and interest payment, Israel's low spending on health as a percentage of GDP and as a percentage of government's spending increases and is closer to the OECD average. Further analysis should explore the effect of additional population and macroeconomic differences on the remaining gaps.

Testing Practices and Attitudes Toward Tests and Testing: An International Survey

Czech Academy of Sciences Publication Activity Database

Evers, A.; McCormick, C. M.; Hawley, L. R.; Muñiz, J.; Balboni, G.; Bartram, D.; Boben, D.; Egeland, J.; El-Hassan, K.; Fernández-Hermida, J.R.; Fine, S.; Frans, Ö.; Gintiliéne, G.; Hagemeister, C.; Halama, P.; Iliescu, D.; Jaworowska, A.; Jiménez, P.; Manthouili, M.; Matesic, K.; Michaelsen, L.; Mogaji, A.; Morley-Kirk, J.; Rózsa, S.; Rowlands, L.; Schittekatte, M.; Sümer, H.C.; Suwartono, T.; Urbánek, Tomáš; Wechsler, S.; Zelenevska, T.; Zanev, S.; Zhang, J.

2017-01-01

Roč. 17, č. 2 (2017), s. 158-190 ISSN 1530-5058 Institutional support: RVO:68081740 Keywords : psychological testing * testing practices * test use * International Test Commission * European Federation of Psychologists' Associations Subject RIV: AN - Psychology OBOR OECD: Psychology (including human - machine relations)

Terrestrial Eco-Toxicological Tests as Screening Tool to Assess Soil Contamination in Krompachy Area

Science.gov (United States)

Ol'ga, Šestinová; Findoráková, Lenka; Hančuľák, Jozef; Fedorová, Erika; Tomislav, Špaldon

2016-10-01

In this study, we present screening tool of heavy metal inputs to agricultural and permanent grass vegetation of the soils in Krompachy. This study is devoted to Ecotoxicity tests, Terrestrial Plant Test (modification of OECD 208, Phytotoxkit microbiotest on Sinapis Alba) and chronic tests of Earthworm (Dendrobaena veneta, modification of OECD Guidelines for the testing of chemicals 317, Bioaccumulation in Terrestrial Oligochaetes) as practical and sensitive screening method for assessing the effects of heavy metals in Krompachy soils. The total Cu, Zn, As, Pb and Hg concentrations and eco-toxicological tests of soils from the Krompachy area were determined of 4 sampling sites in 2015. An influence of the sampling sites distance from the copper smeltery on the absolutely concentrations of metals were recorded for copper, lead, zinc, arsenic and mercury. The highest concentrations of these metals were detected on the sampling sites up to 3 km from the copper smeltery. The samples of soil were used to assess of phytotoxic effect. Total mortality was established at earthworms using chronic toxicity test after 7 exposure days. The results of our study confirmed that no mortality was observed in any of the study soils. Based on the phytotoxicity testing, phytotoxic effects of the metals contaminated soils from the samples 3KR (7-9) S.alba seeds was observed.

Effects of clinical breakpoint changes in CLSI guidelines 2010/2011 and EUCAST guidelines 2011 on antibiotic susceptibility test reporting of Gram-negative bacilli.

Science.gov (United States)

Hombach, Michael; Bloemberg, Guido V; Böttger, Erik C

2012-03-01

The aim of this study was to analyse the effects of clinical breakpoint changes in CLSI 2010 and 2011 guidelines and EUCAST 2011 guidelines on antibiotic susceptibility testing (AST) reports. In total, 3713 non-duplicate clinical isolates of Enterobacteriaceae, Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Acinetobacter baumannii were analysed. Inhibition zone diameters were determined for β-lactams, carbapenems, fluoroquinolones, aminoglycosides and trimethoprim/sulfamethoxazole. CLSI 2009-11 and EUCAST 2011 clinical breakpoints were applied. Changes in resistance as defined per the guidelines affected individual species and drug classes differently. The cefepime resistance rate in Escherichia coli and Enterobacter cloacae increased from 2.1% and 1.3% to 8.2% and 6.9%, respectively, applying CLSI 2009-11 versus EUCAST 2011 guidelines. Ertapenem resistance rates in E. cloacae increased from 2.6% with CLSI 2009 to 7.2% for CLSI 2010 and 2011, and to 10.1% when applying EUCAST 2011. Cefepime and meropenem resistance rates in P. aeruginosa increased from 12.2% and 20.6% to 19.8% and 27.7%, respectively, comparing CLSI 2009-11 with EUCAST 2011. Tobramycin and gentamicin resistance rates in A. baumannii increased from 15.9% and 25.4% to 34.9% and 44.4% applying CLSI 2009-11 versus EUCAST 2011. Higher resistance rates reported due to breakpoint changes in CLSI and EUCAST guidelines will result in increasing numbers of Gram-negative bacilli reported as multidrug resistant. AST reports classifying amoxicillin/clavulanic acid, cefepime or carbapenem resistance will lead clinicians to use alternative agents. Upon implementation of the EUCAST guidelines, laboratories should be aware of the implications of modified drug susceptibility testing reports on antibiotic prescription policies.

Benchmarking health IT among OECD countries: better data for better policy.

Science.gov (United States)

Adler-Milstein, Julia; Ronchi, Elettra; Cohen, Genna R; Winn, Laura A Pannella; Jha, Ashish K

2014-01-01

To develop benchmark measures of health information and communication technology (ICT) use to facilitate cross-country comparisons and learning. The effort is led by the Organisation for Economic Co-operation and Development (OECD). Approaches to definition and measurement within four ICT domains were compared across seven OECD countries in order to identify functionalities in each domain. These informed a set of functionality-based benchmark measures, which were refined in collaboration with representatives from more than 20 OECD and non-OECD countries. We report on progress to date and remaining work to enable countries to begin to collect benchmark data. The four benchmarking domains include provider-centric electronic record, patient-centric electronic record, health information exchange, and tele-health. There was broad agreement on functionalities in the provider-centric electronic record domain (eg, entry of core patient data, decision support), and less agreement in the other three domains in which country representatives worked to select benchmark functionalities. Many countries are working to implement ICTs to improve healthcare system performance. Although many countries are looking to others as potential models, the lack of consistent terminology and approach has made cross-national comparisons and learning difficult. As countries develop and implement strategies to increase the use of ICTs to promote health goals, there is a historic opportunity to enable cross-country learning. To facilitate this learning and reduce the chances that individual countries flounder, a common understanding of health ICT adoption and use is needed. The OECD-led benchmarking process is a crucial step towards achieving this.

Procedure guideline for radioiodine test (version 3); Verfahrensanweisung zum Radioiodtest (Version 3)

Energy Technology Data Exchange (ETDEWEB)

Dietlein, M.; Schicha, H. [Deutsche Gesellschaft fuer Nuklearmedizin (DGN) (Germany); Koeln Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin; Dressler, J. [Deutsche Gesellschaft fuer Nuklearmedizin (DGN) (Germany); Nuklearmedizinische Klinik der Henriettenstiftung, Hannover (Germany); Eschner, W. [Deutsche Gesellschaft fuer Nuklearmedizin (DGN) (Germany); Deutsche Gesellschaft fuer Medizinische Physik (DGMP) (Germany); Koeln Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin; Lassmann, M. [Deutsche Gesellschaft fuer Nuklearmedizin (DGN) (Germany); Deutsche Gesellschaft fuer Medizinische Physik (DGMP) (Germany); Wuerzburg Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin; Leisner, B. [Deutsche Gesellschaft fuer Nuklearmedizin (DGN) (Germany); Allgemeines Krankenhaus St. Georg, Hamburg (Germany). Abt. fuer Nuklearmedizin; Reiners, C. [Deutsche Gesellschaft fuer Nuklearmedizin (DGN) (Germany); Wuerzburg Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin

2007-07-01

The version 3 of the procedure guideline for radioiodine test is an update of the guideline previously published in 2003. The procedure guideline discusses the pros and cons of a single measurement or of repeated measurements of the iodine-131 uptake and their optimal timing. Different formulas are described when one, two or three values of the radioiodine kinetic are available. The probe with a sodium-iodine crystal, alternatively or additionally the gamma camera using the ROI-technique are instrumentations for the measurement of iodine-131 uptake. A possible source of error is an inappropriate measurement (sonography) of the target volume. The patients' preparation includes the withdrawal of antithyroid drugs 2-3 days before radioiodine administration. The patient has to avoid iodine-containing medication and the possibility of additives of iodine in vitamin- and electrolyte-supplementation has to be considered. (orig.)

Migration in OECD countries: Labour Market Impact and Integration Issues. OECD Economics Department Working Papers, No. 562

Science.gov (United States)

Jean, Sebastien; Causa, Orsetta; Jimenez, Miguel; Wanner, Isabelle

2007-01-01

Immigration pressures are increasing in most OECD countries. This paper investigates the consequences of immigration for natives' labour market outcomes, as well as issues linked to immigrants' integration in the host country labour market. Changes in the share of immigrants in the labour force may have a distributive impact on natives' wages, and…

Labour Market Performance, Income Inequality and Poverty in OECD Countries. OECD Economics Department Working Papers, No. 500

Science.gov (United States)

Burniaux, Jean-Marc; Padrini, Flavio; Brandt, Nicola

2006-01-01

There have been concerns that employment-enhancing reforms along the lines of the 1994 OECD Jobs Strategy could inadvertently lead to increased income inequality and poverty. This paper focuses on the impact of institutions and redistributive policies on inequality and poverty with the view of assessing whether a trade-off between better labour…

Recommendations for harmonization of data collection and analysis of developmental neurotoxicity endpoints in regulatory guideline studies: Proceedings of workshops presented at Society of Toxicology and joint Teratology Society and Neurobehavioral Teratology Society meetings.

Science.gov (United States)

Li, Abby A; Sheets, Larry P; Raffaele, Kathleen; Moser, Virginia; Hofstra, Angela; Hoberman, Alan; Makris, Susan L; Garman, Robert; Bolon, Brad; Kaufmann, Wolfgang; Auer, Roland; Lau, Edmund; Vidmar, Thomas; Bowers, Wayne J

2017-09-01

The potential for developmental neurotoxicity (DNT) of environmental chemicals may be evaluated using specific test guidelines from the US Environmental Protection Agency or the Organisation for Economic Cooperation and Development (OECD). These guidelines generate neurobehavioral, neuropathological, and morphometric data that are evaluated by regulatory agencies globally. Data from these DNT guideline studies, or the more recent OECD extended one-generation reproductive toxicity guideline, play a pivotal role in children's health risk assessment in different world areas. Data from the same study may be interpreted differently by regulatory authorities in different countries resulting in inconsistent evaluations that may lead to inconsistencies in risk assessment decisions internationally, resulting in regional differences in public health protection or in commercial trade barriers. These issues of data interpretation and reporting are also relevant to juvenile and pre-postnatal studies conducted more routinely for pharmaceuticals and veterinary medicines. There is a need for development of recommendations geared toward the operational needs of the regulatory scientific reviewers who apply these studies in risk assessments, as well as the scientists who generate DNT data sets. The workshops summarized here draw upon the experience of the authors representing government, industry, contract research organizations, and academia to discuss the scientific issues that have emerged from diverse regulatory evaluations. Although various regulatory bodies have different risk management decisions and labeling requirements that are difficult to harmonize, the workshops provided an opportunity to work toward more harmonized scientific approaches for evaluating DNT data within the context of different regulatory frameworks. Five speakers and their coauthors with neurotoxicology, neuropathology, and regulatory toxicology expertise discussed issues of variability, data reporting

Enhancement of international cooperation for utilization of OECD/NEA Data BAnk

International Nuclear Information System (INIS)

Lee, HaeCho; Chang, JongHwa; Kang, SinBok; Song, TaeGil; Ko, YoungChul; Kim, JinHee; Moon, DongSup; Hwang, HyeSun

2008-06-01

The purpose of research is to register Korean computer codes at OECD/NEA Data Bank and to promote cooperation on use of the computer codes and libraries between the international organization and foreign countries. - 10 computer codes related to nuclear industry have been registered at and supplied to OECD/NEA through this project, which is regarded as good example of close international cooperation among the member states of OECD/NEA - This project has provided member states with motives on creating human networks and high level of expertise between domestic code developers and foreign users of the codes - Expert group in the field of nuclear related computer codes is formed in this project, that is also beneficial for Korea in preparation of exporting and marketing nuclear technologies in the world

Enhancement of international cooperation for utilization of OECD/NEA Data BAnk

Energy Technology Data Exchange (ETDEWEB)

Lee, HaeCho; Chang, JongHwa; Kang, SinBok; Song, TaeGil; Ko, YoungChul; Kim, JinHee; Moon, DongSup; Hwang, HyeSun

2008-06-15

The purpose of research is to register Korean computer codes at OECD/NEA Data Bank and to promote cooperation on use of the computer codes and libraries between the international organization and foreign countries. - 10 computer codes related to nuclear industry have been registered at and supplied to OECD/NEA through this project, which is regarded as good example of close international cooperation among the member states of OECD/NEA - This project has provided member states with motives on creating human networks and high level of expertise between domestic code developers and foreign users of the codes - Expert group in the field of nuclear related computer codes is formed in this project, that is also beneficial for Korea in preparation of exporting and marketing nuclear technologies in the world.

Comparison of approximate electrical energy generating costs in OECD countries

International Nuclear Information System (INIS)

Stevens, G.H.; Bertel, E.

1996-01-01

Costs of power generating in nuclear power plants have been predicted taking into account all factors connected with investment, maintenance, exploitation and decommissioning, basing on last OECD report. The costs have been compared with alternative solutions. In majority of OECD countries the direct costs of electricity generation are very close for nuclear fossil-fuel and gas power plants. All indirect costs such as environmental impact, public health hazard, waste management, accident risk and also public acceptance for nuclear power have been discussed. 13 refs, 5 tabs

Development of a test system for the determination of biodegradability in surface waters

International Nuclear Information System (INIS)

Kalsch, W.; Knacker, T.; Robertz, M.; Schallnass, H.J.

1997-01-01

The study presented here describes the development of a laboratory test system for the determination of aerobic biodegradability of substances at low concentrations in surface water. It was aimed to prepare a draft guideline for a biodegradation simulation test according to OECD format. The experimental approach was based on a literature study conducted within the frame of this project. Further useful information on the possible test design was derived from the German BBA guideline 5-1. Natural water and sediments were collected. Radiolabelled Lindane or 4-Nitrophenol was added. The test vessels (reactors) were aerated and incubated under controlled conditions for up to 92 days. The results showed biological stability of the sediment/water systems even without addition of nutrients and adherence to non-reducing conditions. Mineralisation of 4-Nitrophenol was influenced by the sediment type, the method of aeration and temperature. Factors affecting the mineralisation of Lindane were the method of application and again, the sediment type and temperature. Considerable amounts of the radioactivity were bound to the sediment and were to a large extent unextractable. The potential of a reactor to mineralise a test substance could not be correlated with the biological parameters measured. (orig.) [de

EMQN/CMGS best practice guidelines for the molecular genetic testing of Huntington disease.

Science.gov (United States)

Losekoot, Monique; van Belzen, Martine J; Seneca, Sara; Bauer, Peter; Stenhouse, Susan A R; Barton, David E

2013-05-01

Huntington disease (HD) is caused by the expansion of an unstable polymorphic trinucleotide (CAG)n repeat in exon 1 of the HTT gene, which translates into an extended polyglutamine tract in the protein. Laboratory diagnosis of HD involves estimation of the number of CAG repeats. Molecular genetic testing for HD is offered in a wide range of laboratories both within and outside the European community. In order to measure the quality and raise the standard of molecular genetic testing in these laboratories, the European Molecular Genetics Quality Network has organized a yearly external quality assessment (EQA) scheme for molecular genetic testing of HD for over 10 years. EQA compares a laboratory's output with a fixed standard both for genotyping and reporting of the results to the referring physicians. In general, the standard of genotyping is very high but the clarity of interpretation and reporting of the test result varies more widely. This emphasizes the need for best practice guidelines for this disorder. We have therefore developed these best practice guidelines for genetic testing for HD to assist in testing and reporting of results. The analytical methods and the potential pitfalls of molecular genetic testing are highlighted and the implications of the different test outcomes for the consultand and his or her family members are discussed.

OECD : Euroopa peaks laenuraha odava hoidma / Sirje Rank

Index Scriptorium Estoniae

Rank, Sirje, 1966-

2002-01-01

USA majanduse kiire toibumine võib varsti tuua laenuintresside tõusu, Euroopa Keskpank peaks vähemalt aasta lõpuni ootama ja laskma kasvul juurduda. Diagramm: OECD tõstis majanduskasvu prognoosi. Maksukoormus

OECD Skills Outlook 2013: First Results from the Survey of Adult Skills

Science.gov (United States)

OECD Publishing, 2013

2013-01-01

This first "OECD Skills Outlook" presents the initial results of the Survey of Adult Skills (PIAAC), which evaluates the skills of adults in 22 OECD member countries and two partner countries. The PIAAC survey was designed to provide insights into the availability of some key skills and how they are used at work and at home through the…

Comparison of Early Childhood Education (Preschool Education) in Turkey and OECD Countries

Science.gov (United States)

Ozgan, Habib

2010-01-01

In this study, it was aimed to evaluate how the difference the early childhood education in Turkey and OECD countries. The outstanding point evaluated by the teachers about the difference between the education in Turkey and that in OECD countries and the conditions needing to be improved was the compare of age groups benefiting from the services…

Income inequality and obesity prevalence among OECD countries.

Science.gov (United States)

Su, Dejun; Esqueda, Omar A; Li, Lifeng; Pagán, José A

2012-07-01

Using recent pooled data from the World Health Organization Global Infobase and the World Factbook compiled by the Central Intelligence Agency of the United States, this study assesses the relation between income inequality and obesity prevalence among 31 OECD countries through a series of bivariate and multivariate linear regressions. The United States and Mexico well lead OECD countries in both obesity prevalence and income inequality. A sensitivity analysis suggests that the inclusion or exclusion of these two extreme cases can fundamentally change the findings. When the two countries are included, the results reveal a positive correlation between income inequality and obesity prevalence. This correlation is more salient among females than among males. Income inequality alone is associated with 16% and 35% of the variations in male and female obesity rates, respectively, across OECD countries in 2010. Higher levels of income inequality in the 2005-2010 period were associated with a more rapid increase in obesity prevalence from 2002 to 2010. These associations, however, virtually disappear when the US and Mexico have been excluded from the analysis. Findings from this study underscore the importance of assessing the impact of extreme cases on the relation between income inequality and health outcomes. The potential pathways from income inequality to the alarmingly high rates of obesity in the cases of the US and Mexico warrant further research.

Pensions at a glance 2015 OECD and G20 indicators

CERN Document Server

2016-01-01

The 10-year anniversary edition of Pensions at a Glance highlights the pension reforms undertaken by OECD and G20 countries over the last two years. Two special chapters provide deeper analysis of first-tier pension schemes and of the impact of short or interrupted careers, due to late entry into employment, childcare or unemployment, on pension entitlements. Another chapter analyses the sensitivity of long-term pension replacement rates on various parameters. A range of indicators for comparing pension policies and their outcomes between OECD and G20 countries is also provided.

Taxation and business environment as drivers of foreign direct investment in OECD countries

Czech Academy of Sciences Publication Activity Database

Hájková, Dana; Nicoletti, G.; Vartia, L.; Yoo, K.-Y.

2006/2, č. 43 (2006), s. 7-38 ISSN 0255-0822 R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:AV0Z70850503 Keywords : taxation * foreign direct investment * OECD Subject RIV: AH - Economics http://www.oecd.org/dataoecd/62/30/40505831.pdf

Economic growth and the environment: reassessing the environmental Kuznets Curve for air pollution emissions in OECD countries

NARCIS (Netherlands)

Georgiev, E.S.; Mihaylov, E.S.

2015-01-01

This paper tests the Environmental Kuznets Curve (EKC) hypothesis for four local (SOx, NOx , CO, VOC) and two global (CO2, GHG) air pollutants. Using a panel data set of thirty OECD countries, the paper finds that the postulated inverted U-shaped relationship between income and pollution does not

Applying market-based instruments to environmental policies in China and OECD countries

International Nuclear Information System (INIS)

1998-01-01

China's rapid economic growth since the late 1970s has been a remarkable achievement, and is projected to continue. However, this prospect could be compromised by pollution of air, water, and land, the unsustainable exploitation of natural resources, and the environmental impacts on public health. Air pollution associated with the use of coal for energy and industrial purposes is a particularly serious challenge in China, with important domestic and transboundary implications. This book presents papers from an international workshop co-sponsored by the OECD and China's National Environmental Protection Agency on the application of economic instruments to control air pollution in China and OECD countries. It presents the state-of-the-air in this field, based upon contributions from Chinese and OECD country policy makers and experts

OECD märkab Eesti edusamme / Signe Leesmann

Index Scriptorium Estoniae

Leesmann, Signe

2002-01-01

Vaatamata probleemidele on Eesti ettevõtluskliima paranenud, mille taga näeb OECD Eestisse tulnud välisinvesteeringute ning ekspordi kasvu. Diagrammid: Ettevõtete arv. Ettevõtete struktuur töötajate arvu järgi

OECD/NEA component operational experience, degradation and ageing project

International Nuclear Information System (INIS)

Gott, K.; Nevander, O.; Riznic, J.; Lydell, B.

2015-01-01

Several OECD Member Countries have agreed to establish the OECD/NEA 'Component Operational Experience, Degradation and Ageing Programme' (CODAP) to encourage multilateral co-operation in the collection and analysis of data relating to degradation and failure of metallic piping and non-piping metallic passive components in commercial nuclear power plants. The scope of the data collection includes service-induced wall thinning, part through-wall cracks, through-wall cracks with and without active leakage, and instances of significant degradation of metallic passive components, including piping pressure boundary integrity. CODAP is the continuation of the 2002-2011 'OECD/NEA Pipe Failure Data Exchange Project' (OPDE) and the Stress Corrosion Cracking Working Group of the 2006-2010 - OECD/NEA SCC and Cable Ageing project - (SCAP). OPDE was formally launched in May 2002. Upon completion of the 3. Term (May 2011), the OPDE project was officially closed to be succeeded by CODAP. In May 2011, 13 countries signed the CODAP first Term agreement. The first Term (2011-2014) work plan includes the development of a web-based relational event database on passive, metallic components in commercial nuclear power plants, a web-based knowledge base on material degradation, codes and standards relating to structural integrity and national practices for managing material degradation. The work plan also addresses the preparation of Topical Reports to foster technical cooperation and to deepen the understanding of national differences in ageing management. These Topical Reports are in the public domain and available for download on the NEA web site. Published in 2014, a first Topical Report addressed flow accelerated corrosion (FAC) of carbon steel and low alloy steel piping. A second Topical Report addresses operating experience with electro-hydraulic control (EHC) and instrument air (IA) system piping

A summary of lessons learned activities conducted at the OECD Halden Reactor Project

International Nuclear Information System (INIS)

Hallbert, B.P.

1997-01-01

A series of lessons learned studies have been conducted at the OECD Halden Reactor Project. The purpose of these lessons learned reports are to summarize knowledge and experience gained across a number of research project. This paper presents a summary of main issues addressed in four of these lessons learned projects. These are concerned with software development and quality assurance, software reliability, methods for test and evaluation of developed systems, and the evaluation of system design features

The establishment of an ethical guideline for genetic testing through citizen consensus via the Internet in Taiwan.

Science.gov (United States)

Lin, Chiou-Fen; Lu, Meei-Shiow; Chung, Chun-Chih; Yang, Che-Ming

2010-10-18

With the rapid advance of genetics, the application of genetic testing has become increasingly popular. Test results have had a tremendous impact on individuals who receive the test and his or her family. The ethical, legal, and social implications (ELSI) of genetic testing cannot be overlooked. The Internet is a potential tool for public engagement. This study aimed at establishing ethical guidelines for genetic testing in Taiwan through a participatory citizen consensus approach via the Internet. The research method used was a citizen consensus conference modified by an Internet application and the Delphi technique. The citizen consensus conference is one of the public participation mechanisms. The draft ethical guidelines for genetic testing were written by an expert panel of 10. The Delphi technique was applied to a citizen panel recruited via the Internet until a consensus was reached. Our research population was restricted to people who had Internet access. Included in the citizen panel were 100 individuals. A total of 3 individuals dropped out of the process. The citizen panel was exposed to the issues through Internet learning and sharing. In all, 3 rounds of anonymous questionnaires were administered before a consensus was reached in terms of importance and feasibility. The result was ethical guidelines composed of 4 categories and 25 items. The 4 categories encompassed decision making (6 items), management of tissue samples (5 items), release of results (8 items), and information flow (6 items). On a scale of 1 to 10, the average (SD) importance score for the decision-making category was 9.41 (SD 0.58); for the management of tissue samples category, the average score was 9.62 (SD 0.49); for the release of results category, the average score was 9.34 (SD= 0.59); and for the information flow category, the average score was 9.6 (SD = 0.43). Exploratory analyses indicated that participants with higher education tended to attribute more importance to these

Drivers for renewable energy: A comparison among OECD countries

International Nuclear Information System (INIS)

Gan, Jianbang; Smith, C.T.

2011-01-01

The difference in the shares of renewable energy in total primary energy supply among OECD countries is immense. We attempt to identify some key factors that may have driven this difference for renewable energy in general and bioenergy in particular. We found that besides country-specific factors, gross national product (GDP) and renewable energy and bioenergy market deployment policies have significant and positive impacts on the per capita supply of both renewable energy and bioenergy in OECD countries. R and D expenditures, energy prices, CO 2 emissions, and other energy policies are statistically insignificant in terms of their impact on renewable energy and bioenergy supply. However, this does not necessarily mean that they are not potential drivers for renewable energy and bioenergy, but rather suggests that their magnitudes have not been big enough to significantly influence energy supply based on the historical data from 1994 to 2003. These findings lead to useful policy implications for countries attempting to promote renewable energy and bioenergy development. -- Highlights: ► We identify the drivers of renewable energy development in OECD countries. ► Common drivers include GDP per capita and market deployment policies. ► Country-specific drivers reveal different pathways for bioenergy development.

Trend of glycated hemoglobin testing in diabetic patients: to assess compliance with clinical practice guidelines

International Nuclear Information System (INIS)

Ghayur, S.; Tariq, H.

2013-01-01

Objective: To determine appropriate use of glycated hemoglobin (HbA1c) testing in accordance with current recommended guidelines. Study Design: Descriptive study. Place and Duration of Study: Chemical Pathology Department Shifa International Hospital, Islamabad from Oct 2011 to Oct 2012. Material and Methods: We randomly selected 170 known diabetic patients' data from our Laboratory Information System (LIS) who were retrospective analyzed for HbA1c to check for intervals and test frequency for each patient in one year. Patients with follow-up for at least one year at Shifa International Hospital, Islamabad and having their routine investigations in our chemical pathology laboratory were included. The concentrations of HbA1c for all the specimens were measured immunoturbidimetrically using a microparticle agglutination inhibition method. Four guidelines namely World Health Organization (WHO), American Diabetic Association (ADA), Canadian Diabetic Association (CDA) and National Institute for Health and Clinical Excellence (NICE) about HbA1c testing were utilized for data interpretation. All tests ordered within a 2 months period or more than 6 months following the previous order were labeled as inappropriate. Results: Only 35.8% of the patients were being properly monitored as per guidelines. Out of 64% patients who were inappropriately monitored, 12.9% had repeat orders within 2 months while 51.1% of patients were being monitored at longer interval against recommended guidelines. Conclusions: Glycated hemoglobin is a useful tool to objectively assess the prior glycemic control of patients with type 1 and type 2 diabetes. The study highlights that in large proportion of diabetic patients, HbA1c is not utilized properly as a tool to assess the risk of diabetic complications but in a small proportion is also tested unnecessarily which adds to avoidable health expenditure. (author)

Toxicity tests with crustaceans for detecting sublethal effects of potential endocrine disrupting chemicals

DEFF Research Database (Denmark)

Wollenberger, Leah

/antagonistic activity with the ecdysteroid-responsive Drosophila melanogaster BII cell line 6) to draft an OECD guideline proposal for testing of chemicals based on the experimental work performed within this study In preliminary investigations with A. tonsa were studied various parameters related to processes......New and updated test methods to detect and characterise endocrine disrupting chemicals are urgently needed for the purpose of environmental risk assessment. Although endocrine disruption in invertebrates has not been studied as extensive as in vertebrates, in particular in fish, numerous reports...... of the present Ph.D. project were: 1) to develop a fully synthetic saltwater medium suitable for laboratory culturing of marine copepods including their feeding organism as well as for toxicity testing 2) to identify sensitive endpoints related to growth, development and reproduction of the pelagic calanoid...

Results of extended plant tests using more realistic exposure scenarios for improving environmental risk assessment of veterinary pharmaceuticals.

Science.gov (United States)

Richter, Elisabeth; Berkner, Silvia; Ebert, Ina; Förster, Bernhard; Graf, Nadin; Herrchen, Monika; Kühnen, Ute; Römbke, Jörg; Simon, Markus

2016-01-01

Residues of veterinary medicinal products (VMPs) enter the environment via application of manure onto agricultural areas where in particular antibiotics can cause phytotoxicity. Terrestrial plant tests according to OECD guideline 208 are part of the environmental risk assessment of VMPs. However, this standard approach might not be appropriate for VMPs which form non-extractable residues or transformation products in manure and manure-amended soil. Therefore, a new test design with a more realistic exposure scenario via manure application is needed. This paper presents an extended plant test and its experimental verification with the veterinary antibiotics florfenicol and tylosin tartrate. With each substance, plant tests with four different types of application were conducted: standard tests according to OECD 208 and three tests with application of test substance via spiked manure either without storage, aerobically incubated, or anaerobically incubated for different time periods. In standard tests, the lowest NOEC was tylosin tartrate. Pre-tests showed that plant growth was not impaired at 22-g fresh manure/kg dry soil, which therefore was used for the final tests. The application of the test substances via freshly spiked as well as via aerobically incubated manure had no significant influence on the test results. Application of florfenicol via anaerobically incubated manure increased the EC10 by a factor up to 282 and 540 for half-maximum and for maximum incubation period, respectively. For tylosin tartrate, this factor amounted to 64 at half-maximum and 61 at maximum incubation period. The reduction of phytotoxicity was generally stronger when using cattle manure than pig manure and particularly in tests with cattle manure phytotoxicity decreased over the incubation period. The verification of the extended plant test showed that seedling emergence and growth are comparable to a standard OECD 208 test and reliable effect concentrations could be established. As

Training guidelines in non-destructive testing techniques

International Nuclear Information System (INIS)

1991-10-01

Non-destructive testing methods (NDT), by their very nature, allow components to be fully examined for properties or flaws without interfering with their usefulness. This grouping of inspection methods has grown from a handful of primitive techniques practised by artists to a widely known discipline which is an essential part of quality control, largely as a result of the standards demanded by the nuclear and aerospace industries. Recognizing the need for an international publication of NDT training syllabi, the IAEA Consultants Meeting on ''Qualification and Certification of NDT Personnel'' (Milan, 20-21 May 1986), recommended that the Agency publish the guidelines developed by Regional Working Group of the Latin America and Caribbean project. It was first issued in English in 1987 and has now been re-edited in English and Spanish and enlarged by the addition of programmes for other techniques

An Internal Audit Perspective on Differences between European Corporate Governance Codes and OECD Principles

Directory of Open Access Journals (Sweden)

Raluca Ivan

2015-12-01

Full Text Available The main purpose of this research is to realize an analysis from an internal audit perspective of European Corporate Governance Codes, in regards with Organization for Economic Cooperation and Development – OECD Principles of Corporate Governance. The research methodology used a classification of countries by legal regime, trying to obtain a global view over the differences between the European corporate governance codes and the OECD Principles provisions, from internal audit’s perspective. The findings suggest that the specificities of internal audit function when studying the differences between European Corporate Governance Codes and OECD Principles lead to different treatment.

School-to-Work Transitions in the OECD: Do Education Systems Make a Difference?

Science.gov (United States)

Karmel, Tom

2017-01-01

High unemployment among the young is a concern in many OECD countries. A key issue for policy makers is whether the education system has a role to play in assisting the transition from education to work or whether economic issues dominate. This paper uses OECD country-level data to see whether the structure of countries' education systems,…

OECD Work on Technology and Education: Innovative Learning Environments as an Integrating Framework

Science.gov (United States)

Istance, David; Kools, Marco

2013-01-01

This article presents in summary a selection of the work conducted by OECD in the field of technology and education, which has been an on-going focus of OECD work since the 1980s. Recently, much of this has been under the heading of "New Millennium Learners", but it has also included the widening of student achievement surveys towards…

In vitro cytotoxicity testing of Ubiquicidin 29-41-99mTc

International Nuclear Information System (INIS)

Ocampo, Ivette Z.; Okazaki, Kayo; Dias, Luis Alberto Pereira; Higa, Olga Z.; Silva, Fabiana M. da; Vieira, Daniel P.; Passos, Priscila; Esteves-Pedro, Natalia M.

2015-01-01

The work carried out cytotoxicity tests using a radiopharmaceutical compound produced at IPEN/CNEN-SP to certify its safety through in vitro cytotoxicity tests. Since 2009, the Brazilian regulatory agency (ANVISA) requires that such tests have to be carried out following good laboratory practices (GLP) and in according to the OECD (Organisation for Economic Co-operation and Development) guidelines in order to certify its safety for medical use. Those guidelines comprises series of technical recommendations performed to assure quality of experiments. The study chose Ubiquicidin 29-41, an antimicrobial peptide used to discriminate bacterial infection foci from inflammatory sites. Amounts of UBI 29-41 were conjugated or not to 99m Tc and diluted to equivalent concentrations of 10, 100 and 1000% of the maximum dose (or activity) administered in adults. Possible cytotoxic effects were evaluated in comparison to untreated controls as well as positive and negative damage controls. Both full (radioactive) radiopharmaceuticals, as their precursors (only molecules without conjugation to isotopes) showed no significant cytotoxic effect (cytotoxicity ≤ 10%). The study was conducted for the first time in the country comprising preclinical testing of this radiopharmaceutical in accordance with internationally accepted quality parameters, ensuring the safety of its use and enabling inclusion in the pharmaceutical regulatory agenda. (author)

Implementation, availability and regulatory status of an OECD accepted Reconstructed Human Epidermis model in Brazil

Directory of Open Access Journals (Sweden)

Rodrigo De Vecchi

2018-02-01

Full Text Available Introduction: In 2014, Brazil has joined the growing list of countries to ban cosmetic products from being tested on animal models. The new legislation comes into force in 2019. As a result, the interest for validated alternative testing methods for safety assessment has been increasing in academia, industry and associations. However, the lack of specific legislation on the use of biological material of human origin for toxicological tests makes the access to alternative in vitro models difficult. Furthermore, importation to Brazil is not possible on timely manner. Method: In this article, we report the implementation process of a Reconstructed Human Epidermis (SkinEthic™ RHE, an alternative model internationally accepted by OECD, through a technology transfer from EPISKIN® Lyon to Brazil. Regulatory evolution has been motivating the implementation and wide use of alternative methods to animal testing in several industry segments including cosmetic and pharmaceutical. Results: Protocol has been shown to be robust and highly reproducible. Quality control parameters (histological analysis, barrier function test and tissue viability were performed on 24 batches assembled in Brazil. SkinEthic™ RHE model use allows the full replacement of animal test methods for skin hazards identification. It has regulatory acceptance for several toxicological endpoints, such as the Draize test for skin irritation and corrosion. It allows the reduction and refining of pre-clinical protocols through tiered strategies. Implementation of SkinEthic™ RHE protocol is just a first and important step towards a new approach of toxicological safety testing in Brazil. Conclusion: The implementation was successfully done and reported here. However, in order to follow completely the new legislation up to 2019, the availability of validated models is essential. Quality control tests done on RHE batches produced in Brazil demonstrate that the model met OECD acceptance

OECD Reviews of School Resources: Austria 2016

Science.gov (United States)

Nusche, Deborah; Radinger, Thomas; Busemeyer, Marius R.; Theisens, Henno

2016-01-01

This report for Austria forms part of the Organisation for Economic Cooperation and Development (OECD) Review of Policies to Improve the Effectiveness of Resource Use in Schools. The purpose of the review is to explore how school resources can be governed, distributed, utilised and managed to improve the quality, equity and efficiency of school…

Spillover effects of HIV testing policies: changes in HIV testing guidelines and HCV testing practices in drug treatment programs in the United States

Directory of Open Access Journals (Sweden)

Jemima A. Frimpong

2016-07-01

Full Text Available Abstract Background To examine the extent to which state adoption of the Centers for Disease Control and Prevention (CDC 2006 revisions to adult and adolescent HIV testing guidelines is associated with availability of other important prevention and medical services. We hypothesized that in states where the pretest counseling requirement for HIV testing was dropped from state legislation, substance use disorder treatment programs would have higher availability of HCV testing services than in states that had maintained this requirement. Methods We analyzed a nationally representative sample of 383 opioid treatment programs from the 2005 and 2011 National Drug Abuse Treatment System Survey (NDATSS. Data were collected from program directors and clinical supervisors through telephone surveys. Multivariate logistic regression models were used to measure associations between state adoption of CDC recommended guidelines for HIV pretest counseling and availability of HCV testing services. Results The effects of HIV testing legislative changes on HCV testing practices varied by type of opioid treatment program. In states that had removed the requirement for HIV pretest counseling, buprenorphine-only programs were more likely to offer HCV testing to their patients. The positive spillover effect of HIV pretest counseling policies, however, did not extend to methadone programs and did not translate into increased availability of on-site HCV testing in either program type. Conclusions Our findings highlight potential positive spillover effects of HIV testing policies on HCV testing practices. They also suggest that maximizing the benefits of HIV policies may require other initiatives, including resources and programmatic efforts that support systematic integration with other services and effective implementation.

The local lymph node assay and skin sensitization testing.

Science.gov (United States)

Kimber, Ian; Dearman, Rebecca J

2010-01-01

The mouse local lymph node assay (LLNA) is a method for the identification and characterization of skin sensitization hazards. In this context the method can be used both to identify contact allergens, and also determine the relative skin sensitizing potency as a basis for derivation of effective risk assessments.The assay is based on measurement of proliferative responses by draining lymph node cells induced following topical exposure of mice to test chemicals. Such responses are known to be causally and quantitatively associated with the acquisition of skin sensitization and therefore provide a relevant marker for characterization of contact allergic potential.The LLNA has been the subject of exhaustive evaluation and validation exercises and has been assigned Organization for Economic Cooperation and Development (OECD) test guideline 429. Herein we describe the conduct and interpretation of the LLNA.

PERFORMANCE OF STEEL FIBER REINFORCED CONCRETE – COMPARABILITY OF TESTS ACCORDING TO DAFSTB-GUIDELINE "STAHLFASERBETON" AND EN 14651

Directory of Open Access Journals (Sweden)

Steffen Anders

2016-12-01

Full Text Available For the determination of the performance of steel-fiber reinforced concrete (SFRC, the post-peak flexural strengths are used. In different national and European standards, different test-setups are defined, resulting in double efforts for testing for the manufacturers. In addition, the German national guideline "Stahlfaserbeton (DAfStb" on SFRC is well established European-wide, but the test standard is specifically national, demanding a four-point-bending tests using unnotched beams. Contrarily, the European standard EN 14651 as well as the Model Code 2010 demand three-point bending tests using notched specimens. Applying the national guideline is obligatory in Germany for structural use of SFRC. Therefore, it is essential to standardize the performance evaluation of SFRC based on commonly applied international guidelines. In the following, an approach is presented especially dealing with the problem of random occurrence of cracks in the four-point-bending tests. It is shown, that neglecting the point of crack can systematically under-estimate the performance of SFRC especially at deformations.

Lower extremity amputation rates in people with diabetes as an indicator of health systems performance. A critical appraisal of the data collection 2000-2011 by the Organization for Economic Cooperation and Development (OECD)

NARCIS (Netherlands)

Carinci, F.; Massi Benedetti, M.; Klazinga, N. S.; Uccioli, L.

2016-01-01

Critical appraisal of secondary data made available by the OECD for the time frame 2000-2011. Comparison of trends and variation of amputations in people with diabetes across OECD countries. Generalized estimating equations to test the statistical significance of the annual change adjusting for

Prosobranch snails as test organisms for the assessment of endocrine active chemicals--an overview and a guideline proposal for a reproduction test with the freshwater mudsnail Potamopyrgus antipodarum.

Science.gov (United States)

Duft, Martina; Schmitt, Claudia; Bachmann, Jean; Brandelik, Cornelius; Schulte-Oehlmann, Ulrike; Oehlmann, Jörg

2007-02-01

. antipodarum for a standardized procedure, and this reproduction test will be introduced into the OECD guideline program for standardization in the near future.

Taxation, business environment and FDI location in OECD countries

Czech Academy of Sciences Publication Activity Database

Hájková, Dana; Nicoletti, G.; Vartia, L.; Yoo, K.-Y.

Č. 502 (2006), s. 1-33 Institutional research plan: CEZ:AV0Z70850503 Keywords : taxation * business environment * foreign direct investment Subject RIV: AH - Economics http://www.oecd.org/eco/working_papers

Digital Broadband Content: Digital Content Strategies and policies. OECD Digital Economy Papers, No. 119

Science.gov (United States)

OECD Publishing (NJ1), 2006

2006-01-01

The development of digital content raises new issues as rapid technological developments challenge existing business models and government policies. This OECD study identifies and discusses six groups of business and public policy issues and illustrates these with existing and potential OECD Digital Content Strategies and Policies: (1) Innovation…

Improving Education Achievement and Attainment in Luxembourg. OECD Economics Department Working Papers, No. 508

Science.gov (United States)

Carey, David; Ernst, Ekkehard

2006-01-01

Improving education achievement in Luxembourg is a priority for strengthening productivity growth and enhancing residents' employment prospects in the private sector, where employers mainly hire cross-border workers. Student achievement in Luxembourg is below the OECD average according to the 2003 OECD PISA study, with the performance gap between…

Electricity deregulation in OECD (Organization for Economic Cooperation and Development) countries

Energy Technology Data Exchange (ETDEWEB)

Al-Sunaidy, A.; Green, R. [Business School, University of Hull, Hull HU6 7RX (United Kingdom)

2006-05-15

This paper discusses the spread of electricity deregulation in OECD countries since the early 1990s. England, Wales and Norway were the pioneers, but almost all OECD countries have now introduced some degree of liberalisation, and several have free entry to generation while allowing all electricity consumers to choose where they buy their power. The paper discusses some of the issues raised by competition in generation and in retailing (or supply), and the need to have appropriate regulation for the transmission and distribution systems, which will continue to be monopolies. (author)

2001-2002 carbon dioxide emissions in OECD

International Nuclear Information System (INIS)

2004-11-01

This document provides carbon dioxide emissions data, from energy uses and production, from 2001 to 2002 in the OECD. It concerns the climate corrected CO 2 emissions in France, the non corrected CO 2 emissions (M tons), the emissions intensity / the Gross Domestic Product and the emissions intensity / the population (tons per inhabitant). (A.L.B.)

Význam ,clinical guidelines´ pro určení náležité odborné úrovně poskytování zdravotních služeb

Czech Academy of Sciences Publication Activity Database

Smrž, Ivo

2017-01-01

Roč. 7, č. 1 (2017), s. 13-27 ISSN 1804-8137 Institutional support: RVO:68378122 Keywords : clinical guidelines * medical negligence * liability Subject RIV: AG - Legal Sciences OBOR OECD: Law http://www.ilaw.cas.cz/medlawjournal/index.php/medlawjournal/article/view/133/121

Linking Business Ownership and Perceived Administrative Complexity: An Empirical Analysis of 18 OECD Countries

OpenAIRE

André van Stel; Viktor Stunnenberg

2004-01-01

Administrative burdens are known to be a major business constraint for incumbent SMEs in modern economies. Far less is known about the influence of these burdens on the startup of new firms. The current paper examines to what extent perceived administrative complexity related to starting a new business influences the number of business owners across 18 OECD countries. We test this relationship combining data on business ownership from EIM's COMPENDIA data base and data on perceived administra...

Local tolerance testing under REACH: Accepted non-animal methods are not on equal footing with animal tests.

Science.gov (United States)

Sauer, Ursula G; Hill, Erin H; Curren, Rodger D; Raabe, Hans A; Kolle, Susanne N; Teubner, Wera; Mehling, Annette; Landsiedel, Robert

2016-07-01

In general, no single non-animal method can cover the complexity of any given animal test. Therefore, fixed sets of in vitro (and in chemico) methods have been combined into testing strategies for skin and eye irritation and skin sensitisation testing, with pre-defined prediction models for substance classification. Many of these methods have been adopted as OECD test guidelines. Various testing strategies have been successfully validated in extensive in-house and inter-laboratory studies, but they have not yet received formal acceptance for substance classification. Therefore, under the European REACH Regulation, data from testing strategies can, in general, only be used in so-called weight-of-evidence approaches. While animal testing data generated under the specific REACH information requirements are per se sufficient, the sufficiency of weight-of-evidence approaches can be questioned under the REACH system, and further animal testing can be required. This constitutes an imbalance between the regulatory acceptance of data from approved non-animal methods and animal tests that is not justified on scientific grounds. To ensure that testing strategies for local tolerance testing truly serve to replace animal testing for the REACH registration 2018 deadline (when the majority of existing chemicals have to be registered), clarity on their regulatory acceptance as complete replacements is urgently required. 2016 FRAME.

OECD-IAEA Paks Fuel Project. Final Report

International Nuclear Information System (INIS)

2010-05-01

It is important for nuclear power plant designers, operators and regulators to effectively use lessons learned from events occurring at nuclear power plants since, in general, it is impossible to reproduce the event using experimental facilities. In particular, evaluation of the event using accident analysis codes is expected to contribute to improving understanding of phenomena during the events and to facilitate the validation of computer codes through simulation analyses. The information presented in this publication will be of use in future revisions of safety guides on accident analysis. During a fuel crud removal operation on the Paks-2 unit of the Paks nuclear power plant, Hungary on 10 April 2003, several fuel assemblies were severely damaged. The assemblies were being cleaned in a special tank under deep water in a service pit connected to the spent fuel storage pool. The first sign of fuel failures was the detection of some fission gases released from the cleaning tank. Later, visual inspection revealed that most of the 30 fuel assemblies suffered heavy oxidation and fragmentation. The first evaluation of the event showed that the severe fuel damage had been caused by inadequate cooling. The Paks-2 event was discussed in various committees of the OECD Nuclear Energy Agency (OECD/NEA) and of the International Atomic Energy Agency (IAEA). Recommendations were made to undertake actions to improve the understanding of the incident sequence and of the consequence this had on the fuel. It was considered that the Paks-2 event may constitute a useful case for a comparative exercise on safety codes, in particular for models devised to predict fuel damage and potential releases under abnormal cooling conditions and the analyses of the Paks-2 event may provide information which is relevant for in-reactor and spent fuel storage safety evaluations. The OECD-IAEA Paks Fuel Project was established in 2005 as a joint project between the IAEA and the OECD/NEA. The IAEA

The influence of time on lead toxicity and bioaccumulation determined by the OECD earthworm toxicity test

International Nuclear Information System (INIS)

Davies, N.A.Nicola A.; Hodson, M.E.Mark E.; Black, S.Stuart

2003-01-01

time of artificially amended Pb-bearing soils increases the bioavailability of Pb decreases. Thus addition of worms shortly after addition of Pb to soils may result in the over-estimate of Pb toxicity to worms. The current OECD acute worm toxicity test fails to take these two phenomena into account thereby reducing the environmental relevance of the contaminant toxicities it is used to calculate

Summary of the development the US Environmental Protection Agency's Medaka Extended One Generation Reproduction Test (MEOGRT) using data from 9 multigenerational medaka tests.

Science.gov (United States)

Flynn, Kevin; Lothenbach, Doug; Whiteman, Frank; Hammermeister, Dean; Touart, Leslie W; Swintek, Joe; Tatarazako, Norihisa; Onishi, Yuta; Iguchi, Taisen; Johnson, Rodney

2017-12-01

In response to various legislative mandates, the US Environmental Protection Agency (USEPA) formed its Endocrine Disruptor Screening Program (EDSP), which in turn, formed the basis of a tiered testing strategy to determine the potential of pesticides, commercial chemicals, and environmental contaminants to disrupt the endocrine system. The first tier of tests is intended to detect the potential for endocrine disruption mediated through estrogen, androgen, or thyroid pathways, whereas the second tier is intended to further characterize the effects on these pathways and to establish a dose-response relationship for adverse effects. One of these tier 2 tests, the Medaka Extended One Generation Reproduction Test (MEOGRT), was developed by the USEPA for the EDSP and, in collaboration with the Japanese Ministry of the Environment, for the Guidelines for the Testing of Chemicals of the Organisation for Economic Co-operation and Development (OECD). The MEOGRT protocol was iteratively modified based on knowledge gained after the successful completion of 9 tests with variations in test protocols. The present study describes both the final MEOGRT protocol that has been published by the USEPA and the OECD, and the iterations that provided valuable insights into nuances of the protocol. The various tests include exposure to 17β-estradiol, 4-t-octylphenol, o,p'- dichlorodiphenyltrichloroethane, 4-chloro-3-methylphenol, tamoxifen, 17β-trenbolone, vinclozolin, and prochloraz. Environ Toxicol Chem 2017;36:3387-3403. Published 2017 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America. Published 2017 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.

Flow cytometric determination of micronucleus frequency.

Science.gov (United States)

Elhajouji, Azeddine; Lukamowicz-Rajska, Magdalena

2013-01-01

During the last two decades the micronucleus (MN) test has been extensively used as a genotoxicity screening tool of chemicals and in a variety of exploratory and mechanistic investigations. The MN is a biomarker for chromosomal damage or mitotic abnormalities, since it can originate from chromosome fragments or whole chromosomes that fail to be incorporated into daughter nuclei during mitosis (Fenech et al., Mutagenesis 26:125-132, 2011; Kirsch-Volders et al., Arch Toxicol 85:873-899, 2011). The simplicity of scoring, accuracy, amenability to automation by image analysis or flow cytometry, and readiness to be applied to a variety of cell types either in vitro or in vivo have made it a versatile tool that has contributed to a large extent in our understanding of key toxicological issues related to genotoxins and their effects at the cellular and organism levels. Recently, the final acceptance of the in vitro MN test guideline 487 (OECD Guideline for Testing of Chemicals, In vitro mammalian cell micronucleus test 487. In vitro mammalian cell micronucleus test (MNVIT). Organization for Economic Cooperation and Development, Paris, 2010) together with the standard in vivo MN test OECD guideline 474 (OECD Guideline for The Testing of Chemicals, Mammalian erythrocyte micronucleus test no. 474. Organization for Economic Cooperation and Development, Paris, 1997) will further position the assay as a key driver in the determination of the genotoxicity potential in exploratory research as well as in the regulatory environment. This chapter covers to some extent the protocol designs and experimental steps necessary for a successful performance of the MN test and an accurate analysis of the MN by the flow cytometry technique.

Human Capital Versus Income Variations: Are They Linked in OECD Countries?

Directory of Open Access Journals (Sweden)

Jakub Bartak

2016-03-01

Full Text Available Purpose: The theory of endogenous growth suggests a number of relations between income inequality and human capital. However, empirical evidence in this field is scarce. Therefore, in this paper we aim to demonstrate the existence of interdependencies between income inequality and human capital across OECD countries.Methodology: We present findings of the endogenous growth theory on the mechanisms linking inequality with human capital. Subsequently, we attempt to verify these links empirically using the regression function estimated by means of the generalized method of moments (GMM. The empirical analysis is based on panel data from 1995–2010.Findings: The results of the study reveal the existence of a negative relationship between income inequality and health indicators (infant mortality and maternal mortality. However, we did not reach an authoritative conclusion about the relationship between income inequality and quantitative indicators of educational achievement.Research limitations: Research is limited to the sample of OECD countries. Interdependencies between income inequality and human capital could be captured more clearly using a broader sample.Originality: This paper presents one of few studies testing the relation between human capital and income inequality. The use of high-quality empirical data on inequality (SWIID data and the generalized method of moments made it possible to contribute new arguments to the discussion of empirical analyses of these economic categories.

In vitro cytotoxicity testing of Ubiquicidin 29-41-{sup 99m}Tc

Energy Technology Data Exchange (ETDEWEB)

Ocampo, Ivette Z.; Okazaki, Kayo; Dias, Luis Alberto Pereira; Higa, Olga Z.; Silva, Fabiana M. da; Vieira, Daniel P., E-mail: dpvieira@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Passos, Priscila; Esteves-Pedro, Natalia M., E-mail: fabiana@biosintesis.com.br [Laboratorio Biosintesis Ltda, Sao Paulo, SP (Brazil)

2015-07-01

The work carried out cytotoxicity tests using a radiopharmaceutical compound produced at IPEN/CNEN-SP to certify its safety through in vitro cytotoxicity tests. Since 2009, the Brazilian regulatory agency (ANVISA) requires that such tests have to be carried out following good laboratory practices (GLP) and in according to the OECD (Organisation for Economic Co-operation and Development) guidelines in order to certify its safety for medical use. Those guidelines comprises series of technical recommendations performed to assure quality of experiments. The study chose Ubiquicidin 29-41, an antimicrobial peptide used to discriminate bacterial infection foci from inflammatory sites. Amounts of UBI{sub 29-41} were conjugated or not to {sup 99m}Tc and diluted to equivalent concentrations of 10, 100 and 1000% of the maximum dose (or activity) administered in adults. Possible cytotoxic effects were evaluated in comparison to untreated controls as well as positive and negative damage controls. Both full (radioactive) radiopharmaceuticals, as their precursors (only molecules without conjugation to isotopes) showed no significant cytotoxic effect (cytotoxicity ≤ 10%). The study was conducted for the first time in the country comprising preclinical testing of this radiopharmaceutical in accordance with internationally accepted quality parameters, ensuring the safety of its use and enabling inclusion in the pharmaceutical regulatory agenda. (author)

Training guidelines in non-destructive testing techniques: 2008 ed

International Nuclear Information System (INIS)

2008-12-01

This publication is a revision of IAEA-TECDOC-628/Rev.1 and provides the basic syllabus for systems for training and certification programmes of non-destructive testing (NDT) personnel in accordance with the requirements of international standard ISO 9712 (2005). The training guidelines developed to date have been used by Member States in formulating their national NDT programmes and to provide local end user industries with a skilled workforce. The present publication accommodates the latest advancements in technology and will continue to play an important role towards international harmonization in the field of NDT. This publication contains a body of knowledge for non-destructive testing. It was developed to provide guidelines for trainers, training organizations and certification bodies, detailing the subject matter and the content for each level of certification. It is general in nature but the contents of the training should be adapted to the needs, procedures, materials and products of the customer. The recommended training hours are consistent with the edition of the standard ISO 9712 in effect at the time of preparation. All formal training described in this publication contains a theoretical portion and a practical portion. Guidance is included on the range of equipment and materials needed for instruction in each method. There is a common core of material that is required by level 3 personnel in every method. This common material has been removed from the content for the particular method and included as a separate section. All training should end with an examination and can lead to a certification. Examination and certification are not covered by this publication, but detailed information about this can be found in ISO 9712. This publication is applicable for the following methods: eddy current testing, magnetic particle testing, liquid penetrant testing, radiographic testing, and ultrasonic testing. NDT methods are now widely used in civil engineering

EMQN best practice guidelines for the molecular genetic testing and reporting of chromosome 11p15 imprinting disorders

DEFF Research Database (Denmark)

Eggermann, Katja; Bliek, Jet; Brioude, Frédéric

2016-01-01

of these disorders and the demand for molecular testing, it turned out that there is an urgent need for a standardized molecular diagnostic testing and reporting strategy. Based on the results from the first external pilot quality assessment schemes organized by the European Molecular Quality Network (EMQN) in 2014...... and in context with activities of the European Network of Imprinting Disorders (EUCID.net) towards a consensus in diagnostics and management of SRS and BWS, best practice guidelines have now been developed. Members of institutions working in the field of SRS and BWS diagnostics were invited to comment......, and in the light of their feedback amendments were made. The final document was ratified in the course of an EMQN best practice guideline meeting and is in accordance with the general SRS and BWS consensus guidelines, which are in preparation. These guidelines are based on the knowledge acquired from peer...

The programme of OECD-Nuclear Energy Agency Committee on the safety of nuclear installations principal working group no. 3 on reactor component integrity

International Nuclear Information System (INIS)

Schulz, H.; Miller, A.

1995-01-01

The programme of the OECD-NEA Principal Working Group No.3 on reactor component integrity is described including the following issues: regular Committee meetings; non-destructive testing; fracture analysis; aging; related activities

Selection or network effects? Migration flows into 27 OECD countries, 1990-2000

DEFF Research Database (Denmark)

Pedersen, Peder J.; Pytlikova, Mariola; Smith, Nina

Recent migration patterns show growing migration pressure and changing composition of immigrants in many Western countries. During the latest decade, an increasing proportion of the OECD immigrants have been from poor countries, where the educational level of the population is low. The migration ...... evidence that selection effects have had a major influence on the observed migration patterns until now. This may partly be explained by restrictive migration policies in many OECD countries which may have dampened the potential selection effects....

Selection or Network Effects? Migration Flows into 27 OECD Countries, 1990-2000

DEFF Research Database (Denmark)

Pedersen, P.J.; Pytlikova, Mariola; Smith, Nina

Recent migration patterns show growing migration pressure and changing composition of immigrants in many Western countries. During the latest decade, an increasing proportion of the OECD immigrants have been from poor countries, where the educational level of the population is low. The migration ...... evidence that selection effects have had a major influence on the observed migration patterns until now. This may partly be explained by restrictive migration policies in many OECD countries which may have dampened the potential selection effects....

OECD/NEA Study on the Economics of Long Term Operation of NPP

International Nuclear Information System (INIS)

Lokhov, Alexey; Cameron, Ron

2012-01-01

The OECD Nuclear Energy Agency (NEA) established the Ad Hoc expert group on the Economics of Long-term Operation (LTO) of Nuclear Power Plants. The primary aim of this group is to collect and analyse technical and economic data on the upgrade and lifetime extension experience in OECD countries, and to assess the likely applications for future extensions. This paper describes the key elements of the methodology of economic assessment of LTO and initial findings for selected NEA member countries. (author)

The Chemistry of iodine in reactor safety: summary and conclusions: OECD Workshop

International Nuclear Information System (INIS)

1996-01-01

About seventy experts from fourteen OECD member countries attended this Fourth OECD Workshop on the chemistry of iodine in reactor safety, as well as experts from Latvia and the Commission of the European Communities. Thirty four papers were presented, in five sessions: national and international programmes (integral and intermediate-scale experiments), experimental homogeneous phase chemistry, surface processes, thermodynamic and kinetic studies, safety applications. A final session is devoted to a general discussion on remaining research studies relevant to reactor safety

Deaths from international terrorism compared with road crash deaths in OECD countries.

Science.gov (United States)

Wilson, N; Thomson, G

2005-12-01

To estimate the relative number of deaths in member countries of the Organisation for Economic Co-operation and Development (OECD) from international terrorism and road crashes. Data on deaths from international terrorism (US State Department database) were collated (1994-2003) and compared to the road injury deaths (year 2000 and 2001 data) from the OECD International Road Transport Accident Database. In the 29 OECD countries for which comparable data were available, the annual average death rate from road injury was approximately 390 times that from international terrorism. The ratio of annual road to international terrorism deaths (averaged over 10 years) was lowest for the United States at 142 times. In 2001, road crash deaths in the US were equal to those from a September 11 attack every 26 days. There is a large difference in the magnitude of these two causes of deaths from injury. Policy makers need to be aware of this when allocating resources to preventing these two avoidable causes of mortality.

The OECD/NEA/NSC PBMR coupled neutronics/thermal hydraulics transient benchmark: The PBMR-400 core design

International Nuclear Information System (INIS)

Reitsma, F.; Ivanov, K.; Downar, T.; De Haas, H.; Gougar, H. D.

2006-01-01

The Pebble Bed Modular Reactor (PBMR) is a High-Temperature Gas-cooled Reactor (HTGR) concept to be built in South Africa. As part of the verification and validation program the definition and execution of code-to-code benchmark exercises are important. The Nuclear Energy Agency (NEA) of the Organisation for Economic Cooperation and Development (OECD) has accepted, through the Nuclear Science Committee (NSC), the inclusion of the Pebble-Bed Modular Reactor (PBMR) coupled neutronics/thermal hydraulics transient benchmark problem in its program. The OECD benchmark defines steady-state and transients cases, including reactivity insertion transients. It makes use of a common set of cross sections (to eliminate uncertainties between different codes) and includes specific simplifications to the design to limit the need for participants to introduce approximations in their models. In this paper the detailed specification is explained, including the test cases to be calculated and the results required from participants. (authors)

Discussion of OECD LWR Uncertainty Analysis in Modelling Benchmark

International Nuclear Information System (INIS)

Ivanov, K.; Avramova, M.; Royer, E.; Gillford, J.

2013-01-01

The demand for best estimate calculations in nuclear reactor design and safety evaluations has increased in recent years. Uncertainty quantification has been highlighted as part of the best estimate calculations. The modelling aspects of uncertainty and sensitivity analysis are to be further developed and validated on scientific grounds in support of their performance and application to multi-physics reactor simulations. The Organization for Economic Co-operation and Development (OECD) / Nuclear Energy Agency (NEA) Nuclear Science Committee (NSC) has endorsed the creation of an Expert Group on Uncertainty Analysis in Modelling (EGUAM). Within the framework of activities of EGUAM/NSC the OECD/NEA initiated the Benchmark for Uncertainty Analysis in Modelling for Design, Operation, and Safety Analysis of Light Water Reactor (OECD LWR UAM benchmark). The general objective of the benchmark is to propagate the predictive uncertainties of code results through complex coupled multi-physics and multi-scale simulations. The benchmark is divided into three phases with Phase I highlighting the uncertainty propagation in stand-alone neutronics calculations, while Phase II and III are focused on uncertainty analysis of reactor core and system respectively. This paper discusses the progress made in Phase I calculations, the Specifications for Phase II and the incoming challenges in defining Phase 3 exercises. The challenges of applying uncertainty quantification to complex code systems, in particular the time-dependent coupled physics models are the large computational burden and the utilization of non-linear models (expected due to the physics coupling). (authors)

NASA Electronic Parts and Packaging (NEPP) Field Programmable Gate Array (FPGA) Single Event Effects (SEE) Test Guideline Update

Science.gov (United States)

Berg, Melanie D.; LaBel, Kenneth A.

2018-01-01

The following are updated or new subjects added to the FPGA SEE Test Guidelines manual: academic versus mission specific device evaluation, single event latch-up (SEL) test and analysis, SEE response visibility enhancement during radiation testing, mitigation evaluation (embedded and user-implemented), unreliable design and its affects to SEE Data, testing flushable architectures versus non-flushable architectures, intellectual property core (IP Core) test and evaluation (addresses embedded and user-inserted), heavy-ion energy and linear energy transfer (LET) selection, proton versus heavy-ion testing, fault injection, mean fluence to failure analysis, and mission specific system-level single event upset (SEU) response prediction. Most sections within the guidelines manual provide information regarding best practices for test structure and test system development. The scope of this manual addresses academic versus mission specific device evaluation and visibility enhancement in IP Core testing.

Human machine interaction research experience and perspectives as seen from the OECD Halden Reactor Project

International Nuclear Information System (INIS)

Oewre, F.

1999-01-01

In this paper a short review is given on important safety issues in the field of human machine interaction as expressed by important nuclear organisations such as USNRC, IAEA and the OECD NEA. Further on, a presentation is offered of research activities at the OECD Halden Reactor Project in the field of human machine interaction aiming to clarify some of the issues outlined by the above mentioned organisations. The OECD Halden Reactor Project is a joint undertaking of national nuclear organisations in 19 countries sponsoring a jointly financed research programme under the auspices of the OECD - Nuclear Energy Agency. One of the research areas is the man-machine systems research addressing the operator tasks in a control room environment. The overall objective is to provide a basis for improving today's control rooms through introduction of computer-based solutions for effective and safe execution of surveillance and control functions in normal as well as off-normal plant situations. (author)

Role of Attractiveness Factors of the OECD Countries in Immigrations

Directory of Open Access Journals (Sweden)

Kristina Duvnjak

2017-12-01

Full Text Available An influx of immigrants to developed countries, is an ongoing process that lasts for centuries. Numerous researches have been written encouraged by this topic. Today’s free labor market enables immigrants to become a very influential aspect of every economy. With general stagnation and aging of word population, especially European, a question about level of immigration impact on active labor market appears. This paper is testing the stated, what are the factors that attract immigrants in OECD countries. Considering the main factors that encourage immigrants to migrate in specific country, this paper is testing how total GDP per country, as an indicator of level of economic growth, and social spending, as an indicator of support to those who need it, influence on their decision. The determined variable is asylum seeker as it is much precise in stating the thesis. The cross-section model which is used with 2015 data shows significant results.

EU and OECD benchmarking and peer review compared

NARCIS (Netherlands)

Groenendijk, Nico

2009-01-01

Benchmarking and peer review are essential elements of the so-called EU open method of coordination (OMC) which has been contested in the literature for lack of effectiveness. In this paper we compare benchmarking and peer review procedures as used by the EU with those used by the OECD. Different

An economic analysis of a major bio-fuel program undertaken by OECD countries

International Nuclear Information System (INIS)

2002-01-01

Biofuels such as ethanol and bio-diesel are creating a new demand for agricultural output and for agriculture land in Canada. However, the participation of other large countries with a large demand potential is necessary for bio-fuels to have a significant impact on the price of grains and oilseeds. This paper quantified the potential impact that a major bio-fuel program initiated by OECD countries has on grain and oilseed prices. The program was initiated for the period 1999 to 2006. There is considerable interest by Canadian producers to stimulate grain and oilseed prices by increasing demand of biofuels. This renewable energy source produces fewer greenhouse gas emissions than petroleum products. The analysis presented in this paper only considered ethanol from corn or wheat and bio-diesel from vegetable oils. It also focused only on the use of bio-fuels in the OECD transportation sector. The analysis was undertaken with AGLINK, a multi-commodity multi-country policy-specific dynamic model of the international agricultural markets built by the OECD with member countries. It was shown that the increase in world and domestic prices for grains and vegetable oils will remain strong, particularly toward 2006. It was also shown that a major bio-fuel program for all OECD countries would be beneficial to Canadian agriculture. It was concluded that ultimately, an increase in OECD bio-fuels usage has a direct impact on the demand for grains and oilseeds which are important feed-stocks in biofuel production. The analysis presumes an increase in renewable fuel use, but does not consider factors such as financial incentives and regulatory requirements that could bring about this increase. 7 refs., 6 tabs., 4 figs

40 CFR 799.9355 - TSCA reproduction/developmental toxicity screening test.

Science.gov (United States)

2010-07-01

... developmental defects should not be used. Healthy virgin animals, not subjected to previous experimental..., except legal holidays. (1) OECD (1995). Reproduction/Developmental Toxicity Screening Test, OECD 421...

Charcot-Marie-Tooth disease: frequency of genetic subtypes and guidelines for genetic testing.

LENUS (Irish Health Repository)

Murphy, Sinead M

2012-07-01

Charcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous group of diseases with approximately 45 different causative genes described. The aims of this study were to determine the frequency of different genes in a large cohort of patients with CMT and devise guidelines for genetic testing in practice.

INNOVATION POLICY FEATURES IN THE OECD COUNTRIES

Directory of Open Access Journals (Sweden)

Ivan Anisimov

2015-11-01

Full Text Available The purpose of the paper is to analyze the innovation policy features in the OECD countries and give the basic framework which defines rights and obligations of intellectual property rights (IPRs owners. Governments play an important role in determining demand-side policies, such as smart regulations, standards, consumer education, taxation and public procurement that can affect innovation. Because demand linked to supply, policies that affect both need to be better harnessed to drive long-term innovation and sustainable growth. Policies to stimulate innovation require taking account of changes in the international economy and the transformation of innovation processes. To transform invention into innovation requires a range of activities. Innovation now encompasses much more than research and development (R&D, albeit R&D remains vitally important. Methodology. The data for the paper is taken from the publications and reports of the European Commission, OECD, World Bank etc. In the paper the descriptive analysis, supported by the quantitative analysis is applied. Results. It is identified that rises in R&D intensity and innovation are driven by such factors: reduction of anti-competitive market regulations, which promotes business R&D and strengthens the incentives for innovations; stable economic conditions and low interest rates which encourage the growth of inno vation activity by creating a low-cost environment for investment in innovation; availability of internal and external finance. Practical implication. It is given the basic legal framework which defines rights and obligations of IPR owners: reviewing exemptions to copyright in the light of the internet’s different uses; clarifying exemptions for research use; promoting an active and open commercialization policy for universities; encouraging the commercialization and monetization of IPR: for example draft licensing contracts, valuation standards; standards: encouraging pooling

Analysis of OECD/CSNI ISP-42 phase A PANDA experiment using coupled code R5G (RELAP5-GOTHIC)

International Nuclear Information System (INIS)

Bencik, V.; Debrecin, N.; Grgic, D.; Bajs, T.

2010-01-01

In the paper, the results of the analysis of OECD/CSNI ISP-42 Phase A experiment at PANDA facility using stand-alone codes RELAP5/mod3.3 and GOTHIC 7.2b as well as coupled code R5G (RELAP5/mod3.3-GOTHIC 7.2b) are presented. PANDA is a large-scale thermal-hydraulic test facility installed at PSI (Paul Scherrer Institute) in Switzerland. The OECD/CSNI ISP-42 test consists of six sequential phases (Phase A through F). The present work deals with the post-test calculation of the Phase A, including the break of the main steam line and the Passive Containment Cooling (PCC) System Start-Up. The objective of the test is to investigate the start-up phenomenology of passive cooling system when steam is injected into cold vessel filled with air. The calculation was performed using stand-alone RELAP5/mod3.3 and GOTHIC 7.2b models, and then the same calculation was performed using coupled code with RELAP5 being responsible for reactor part of the model and GOTHIC being responsible for containment part of the model. The prediction capability, running time and modeling aspects were discussed for all three cases. (authors)

A Simulation Study about OECD-SETH PANDA Tests by using MARS Code

International Nuclear Information System (INIS)

Bae, Sung Won; Chung, Bub Dong

2007-04-01

Korea Advanced Energy Research Institute (KAERI) conceived and started the development of MARS code with the main objective of producing a state-of-the-art realistic thermal hydraulic systems analysis code with multi-dimensional analysis capability. MARS achieves this objective by integrating the one dimensional RELAP5/MOD3 with the multi-dimensional COBRA-TF codes. The method of integration of the two codes is based on the dynamic link library techniques, and the system pressure equation matrices of both codes are implicitly integrated and solved simultaneously. In addition, the Equation-Of-State (EOS) for the light water was unified by replacing the EOS of COBRA-TF by that of the RELAP5. In addition, the multi-D module component has been developed to meet the expand the multi-dimensional analysis capability of MARS. Participating in OECD-SETH, MARS provides and undergoes the assess procedure of comercial CFD codes, like FLUENT, CFX, etc. During the participation, MARS has been used to provide the system code results, which is made with the intermediate length scale, restricted analysis volume numbers. With these restrictions and shortcomings, MARS predicts well about the steam concentration distribution and mixture temperature in the large multi-comparted bulk spaces. After the SETH project, NEA has planned the SETH II, which deals with the multiple non-condensible gas stratification and mixing phenomena

Energy balances of non-OECD countries, 2001-2002. 2004 edition

International Nuclear Information System (INIS)

2004-01-01

This volume contains data on the supply and consumption of coal, oil, gas, electricity, heat, renewables and waste presented as comprehensive energy balances, expressed in tonnes of oil equivalent for over 100 non-OECD countries. Historical tables summarize production, trade and final consumption data as well as key energy and economic indicators. This book includes definitions of products and flows, explanatory notes on the individual country data and conversion factors from original units to tonnes of oil equivalent. More detailed data in original units are published in Energy Statistics of Non-OECD Countries 2001-2002, the sister volume of this publication. Bi-lingual edition: English - French. In general the CD-Rom and on-line service contain detailed time-series back to 1971

Test and evaluation on safety relating to biotechnology; Biotechnology ni kansuru anzensei no shiken to hyoka

Energy Technology Data Exchange (ETDEWEB)

Okada, M. [Bio-Oriented Technology Research Advancement Inst., Saitama (Japan)

1996-09-05

This paper describes the current status and how works are being carried out on safety tests and evaluation of gene recombinants in plants and microorganisms. In the field of plants, Flavr Savr tomato which has been improved in fully ripe fruit distribution and keeping quality was commercialized as the world`s first recombinant food in May 1994 by Calgene, Inc. of America. Other vegetables, such as soybean, corn, potato, and pumpkin have been completed of all items of safety evaluation, and are approaching the commercialization phase. The safety evaluation system for living organisms created by using recombinant DNA technologies has been established internationally with regard to its general framework and contents based on accumulated knowledeges and experiences as a result of utilization of over twenty years. Industrial utilization guidelines for recombinants in Japan have been established in correspondence with the OECD recommendation in 1986. Experiments to verify recombinants to be safe in environment, and cultivation of the recombinants for utilization are performed based on the experimental guidelines and utilization guidelines. 15 refs., 1 fig., 5 tabs.

European Society of Contact Dermatitis guideline for diagnostic patch testing -- recommendations on best practice

DEFF Research Database (Denmark)

Johansen, Jeanne D; Aalto-Korte, Kristiina; Agner, Tove

2015-01-01

The present guideline summarizes all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed-type hypersensitivity skin and mucosal conditions. Sections with brief descriptions an...

Trends and determinants of weight gains among OECD countries: an ecological study.

Science.gov (United States)

Nghiem, S; Vu, X-B; Barnett, A

2018-06-01

Obesity has become a global issue with abundant evidence to indicate that the prevalence of obesity in many nations has increased over time. The literature also reports a strong association between obesity and economic development, but the trend that obesity growth rates may converge over time has not been examined. We propose a conceptual framework and conduct an ecological analysis on the relationship between economic development and weight gain. We also test the hypothesis that weight gain converges among countries over time and examine determinants of weight gains. This is a longitudinal study of 34 Organisation for Economic Cooperation and Development (OECD) countries in the years 1980-2008 using publicly available data. We apply a dynamic economic growth model to test the hypothesis that the rate of weight gains across countries may converge over time. We also investigate the determinants of weight gains using a longitudinal regression tree analysis. We do not find evidence that the growth rates of body weight across countries converged for all countries. However, there were groups of countries in which the growth rates of body weight converge, with five groups for males and seven groups for females. The predicted growth rates of body weight peak when gross domestic product (GDP) per capita reaches US$47,000 for males and US$37,000 for females in OECD countries. National levels of consumption of sugar, fat and alcohol were the most important contributors to national weight gains. National weight gains follow an inverse U-shape curve with economic development. Excessive calorie intake is the main contributor to weight gains. Copyright © 2018 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

Application of the MiniPanda test case ‘erosion of a stratified layer by a vertical jet’ for CFD validation

Energy Technology Data Exchange (ETDEWEB)

Kelm, Stephan, E-mail: s.kelm@fz-juelich.de [Forschungszentrum Juelich, Institute for Energy and Climate Research (IEK-6) (Germany); Ritterath, Martin; Prasser, Horst-Michael [ETH Zurich, Laboratory of Nuclear Energy Systems (LKE) (Switzerland); Allelein, Hans-Josef [Forschungszentrum Juelich, Institute for Energy and Climate Research (IEK-6) (Germany); RWTH Aachen University, Institute for Reactor Safety and Technology (LRST) (Germany)

2016-04-01

Highlights: • Small-scale experiment with innovative temperature wire mesh field measurements. • Discussion of benefits and limitations of small-scale setup regarding existing data base. • Systematic validation of a U-RANS model under consideration of best practice guidelines. • Quantitative point-to-point and phenomenological field-to-field comparison. - Abstract: In order to allow development and validation of CFD models for hydrogen mixing and transport in the containment, a comprehensive experimental test campaign was performed at the small scale MiniPanda facility at ETH Zurich. The considered test series aimed at studying the turbulent erosion of a stratified light gas by means of a vertical air jet with different momenta. Due to its new and innovative measurements, e.g., with temperature wire mesh sensors, the global mixing and the local interaction of jet and stratification are characterized in a high resolution in space and time. Both are essential for a detailed model assessment, to identify possible error sources and rate their effect on the global scenario evolution. Consequently, the tests are well suited for CFD model development and validation and complement the data basis gained before, e.g., in the frame of the joint OECD/NEA-SETH-2 Project (2007–2010) (OECD/NEA, 2012). Based on a description of the MiniPanda facility and the ‘layer erosion’ test series, the application of a U-RANS CFD approach, capable to be applied also for large scale application, is discussed. Numerical model uncertainties are minimized according to the best practice guidelines before a systematic comparison against the experimental data is performed and the capability of the model to predict the turbulent mixing at the interface and the inter-compartment mass transfer is successfully validated.

Summary record of the experts meeting on the proposed OECD-IRSN STLOC project

International Nuclear Information System (INIS)

2004-01-01

The purpose of this meeting was to determine the interest in member countries for the types of LOCA tests envisaged in the STLOC programme proposed by IRSN. The IRSN proposal was circulated among this Group in advance of the meeting. After the presentations and discussions, the Group recommendations were as follows: different views were expressed as to the need to perform the LOCA integral tests; there was an understanding that the results of separate effect tests (ANL, JAERI, Halden) would need to be obtained before deciding on the intended LOCA tests proposed in STLOC; IRSN and the OECD-NEA should explore the possibility to run the first ST test with air ingress (STLOC1), for which partial funding already exists (this test is foreseen for 2008); the need of LOCA tests as envisaged in STLOC should be re-assessed in about three years time (2006); analytical and experimental progress on LOCA tests should be monitored until then, through for instance the SEGFSM. An executive summary of the IRSN Source term LOCA program LOCA part is given in an appendix

OECD: andke töötukassale raha juurde/ Laura Raus

Index Scriptorium Estoniae

Raus, Laura

2011-01-01

Majanduskoostöö ja Arengu Organisatsiooni (OECD) riigiülevaate üksuse asejuht Robert Ford tutvustas organisatsiooni raportit Eesti majanduse kohta. Rahandusminister Jürgen Ligi ei pea kõiki soovitusi Eestile sobivaks

Babies and bosses: reconciling work and family life : a synthesis of findings for OECD countries

National Research Council Canada - National Science Library

2007-01-01

... of population ageing, and well-designed policies may also help raise fertility rates from the exceptionally low levels that exist in some countries. In recent years, the OECD Babies and Bosses reviews of policies to promote work and family reconciliation covered Australia, Denmark and the Netherlands (OECD, 2002a); Austria, Ireland and ...

An OECD comparison of wind power and photovoltaics - approach to a consistent survey

International Nuclear Information System (INIS)

Wagner, H.J.; Ziemons, S.

1996-01-01

Adequate solutions are expected from renewable energy sources that may stop ozone depletion and contribute to resource conservation. Almost any OECD country is making efforts to promote photovoltaics and wind power. To give a survey of the measures taken and results obtained promotion programs are compared and the success achieved in the individual OECD countries is outlined. National energy institutions were interviewed and their 1993/94 programs were evaluated. Some of the data and statements are incomplete. (orig.) [de

OECD Health Care Quality Indicator Project. The expert panel on primary care prevention and health promotion

NARCIS (Netherlands)

Marshall, Martin; Klazinga, Niek; Leatherman, Sheila; Hardy, Charlie; Bergmann, Eckhard; Pisco, Luis; Mattke, Soeren; Mainz, Jan

2006-01-01

PURPOSE: This article describes a project undertaken as part of the Organization for Economic Co-operation and Development (OECD)'s Healthcare Quality Indicator (HCQI) Project, which aimed to develop a set of quality indicators representing the domains of primary care, prevention and health

Unemployment and prostate cancer mortality in the OECD, 1990-2009.

Science.gov (United States)

Maruthappu, Mahiben; Watkins, Johnathan; Taylor, Abigail; Williams, Callum; Ali, Raghib; Zeltner, Thomas; Atun, Rifat

2015-01-01

The global economic downturn has been associated with increased unemployment in many countries. Insights into the impact of unemployment on specific health conditions remain limited. We determined the association between unemployment and prostate cancer mortality in members of the Organisation for Economic Co-operation and Development (OECD). We used multivariate regression analysis to assess the association between changes in unemployment and prostate cancer mortality in OECD member states between 1990 and 2009. Country-specific differences in healthcare infrastructure, population structure, and population size were controlled for and lag analyses conducted. Several robustness checks were also performed. Time trend analyses were used to predict the number of excess deaths from prostate cancer following the 2008 global recession. Between 1990 and 2009, a 1% rise in unemployment was associated with an increase in prostate cancer mortality. Lag analysis showed a continued increase in mortality years after unemployment rises. The association between unemployment and prostate cancer mortality remained significant in robustness checks with 46 controls. Eight of the 21 OECD countries for which a time trend analysis was conducted, exhibited an estimated excess of prostate cancer deaths in at least one of 2008, 2009, or 2010, based on 2000-2007 trends. Rises in unemployment are associated with significant increases in prostate cancer mortality. Initiatives that bolster employment may help to minimise prostate cancer mortality during times of economic hardship.

GfW-handbook for irradiation test guidelines for radiation hardness of electronic components

International Nuclear Information System (INIS)

Braeunig, D.; Wulf, F.; Gaebler, W.; Boden, A.

1982-12-01

The purpose of the report is to propose irradiation test methods so that a standardized application of the methods can lead to a better comparison of test results. The interaction of different radiation species with matter - ionization and displacement - is described. Application of appropriate radiation sources, dosimetry problems, and shielding for simulating space radiation effects by laboratory testing is discussed. The description and characteristics of the irradiation sources are presented. Flowcharts of the planning and running of irradiation tests are given. Guidelines for running the tests are established, test methods and test circuits are proposed. The test system offers the capability of measuring devices also of high complexity up to microprocessors. The test results are collected regularly and are published in GfW-Handbook TN53/08, 'Data Compilation of Irradiation Tested Electronic Components'. (orig./HP) [de

Avoidance, biomass and survival response of soil dwelling (endogeic) earthworms to OECD artificial soil: potential implications for earthworm ecotoxicology.

Science.gov (United States)

Brami, C; Glover, A R; Butt, K R; Lowe, C N

2017-05-01

Soil dwelling earthworms are now adopted more widely in ecotoxicology, so it is vital to establish if standardised test parameters remain applicable. The main aim of this study was to determine the influence of OECD artificial soil on selected soil-dwelling, endogeic earthworm species. In an initial experiment, biomass change in mature Allolobophora chlorotica was recorded in Standard OECD Artificial Soil (AS) and also in Kettering Loam (KL). In a second experiment, avoidance behaviour was recorded in a linear gradient with varying proportions of AS and KL (100% AS, 75% AS + 25% KL, 50% KS + 50% KL, 25% AS + 75% KL, 100% KL) with either A. chlorotica or Octolasion cyaneum. Results showed a significant decrease in A. chlorotica biomass in AS relative to KL, and in the linear gradient, both earthworm species preferentially occupied sections containing higher proportions of KL over AS. Soil texture and specifically % composition and particle size of sand are proposed as key factors that influenced observed results. This research suggests that more suitable substrates are required for ecotoxicology tests with soil dwelling earthworms.

An Emerging Knowledge-Based Economy in China? Indicators from OECD Databases. OECD Science, Technology and Industry Working Papers, 2004/4

Science.gov (United States)

Criscuolo, Chiara; Martin, Ralf

2004-01-01

The main objective of this Working Paper is to show a set of indicators on the knowledge-based economy for China, mainly compiled from databases within EAS, although data from databases maintained by other parts of the OECD are included as well. These indicators are put in context by comparison with data for the United States, Japan and the EU (or…

Summary of nuclear power and fuel cycle data in OECD member countries

International Nuclear Information System (INIS)

1986-04-01

A questionnaire on Electricity Generation, Nuclear Power and Fuel Cycle Data is distributed annually to OECD Member Countries. In the questionnaire of January 1986, countries were asked to provide historical data for 1984 and 1985 and most likely projections up to the year 2005. The replies to the questionnaire are presented in this Summary. Not all countries have revised or made new projections since the April 1985 issue. Too few countries were able to provide projections beyond 2000 to include data for 2005 in this year's Summary. Data for 1985 are in some cases provisional. Where no data were available the Secretariat made estimates, based on information of IEA, IAEA, the previous Brown Book, OECD/IEA Energy Statistics and other sources. The electricity generation and production data for fuel cycle services refer to those facilities located within the country, and thus exclude imports. The fuel cycle requirements, however, refer to the amounts of fuel cycle services necessary for national nuclear power programmes. The Addendum contains an analysis of the present and past projections for OECD nuclear capacity to 2000

A Comparative Study of Suicide Rates among 10–19-Year-Olds in 29 OECD Countries

Science.gov (United States)

Roh, Beop-Rae; Jung, Eun Hee; Hong, Hyun Ju

2018-01-01

Objective This study had two main objectives: to compare current suicide rates in OECD countries among 10–19-year-olds and to identify patterns of suicide rates based on age, gender and time. Furthermore we investigated the main dimensions that contributed to the variation in child and adolescent suicide rates across countries. Methods We combined the WHO mortality data and the population data released by OECD to calculate the suicide rates in 29 OECD countries. A self-organizing map (SOM), k-means clustering analysis, and multi-dimensional scaling were used to classify countries based on similarities in suicide rate structure and to identify the important dimensions accounting for differences among groups. Results We identified significant differences in suicide rates depending on age, sex, country, and time period. Late adolescence and male gender were universal risk factors for suicide, and we observed a general trend of declining suicide rates in OECD countries. The SOM analysis yielded eight types of countries. Most countries showed gender gaps in suicide rates of similar magnitudes; however, there were outliers in which the gender gap was particularly large or small. Conclusion Significant variation exists with respect to suicide rates and their associated gender gaps in OECD countries. PMID:29486551

Fish early life stage: Developing AOPs to support targeted reduction and replacement

Science.gov (United States)

There is an interest in developing alternatives to the fish early-life stage (FELS) test (OECD test guideline 210), for predicting adverse chronic toxicity outcomes (e.g., impacts on growth and survival). Development and characterization of adverse outcome pathways (AOPs) related...

Energy efficiency of selected OECD countries: A slacks based model with undesirable outputs

International Nuclear Information System (INIS)

Apergis, Nicholas; Aye, Goodness C.; Barros, Carlos Pestana; Gupta, Rangan; Wanke, Peter

2015-01-01

This paper presents an efficiency assessment of selected OECD countries using a Slacks Based Model with undesirable or bad outputs (SBM-Undesirable). In this research, SBM-Undesirable is used first in a two-stage approach to assess the relative efficiency of OECD countries using the most frequent indicators adopted by the literature on energy efficiency. Besides, in the second stage, GLMM–MCMC methods are combined with SBM-Undesirable results as part of an attempt to produce a model for energy performance with effective predictive ability. The results reveal different impacts of contextual variables, such as economic blocks and capital–labor ratio, on energy efficiency levels. - Highlights: • We analyze the energy efficiency of selected OECD countries. • SBM-Undesirable and MCMC–GLMM are combined for this purpose. • Find that efficiency levels are high but declining over time. • Analysis with contextual variables shows varying efficiency levels across groups. • Capital-intensive countries are more energy efficient than labor-intensive countries.

Implementation of MOAS II diagnosis system at the OECD Halden Reactor project

International Nuclear Information System (INIS)

Kim, I.S.; Grini, R.E.; Nilsen, S.

1995-01-01

MOAS II is a surveillance and diagnosis system that uses several techniques for knowledge acquisition and diagnostic reasoning, e.g., goal tree-success tree, simplified directed graphs, diagnosis trees, and detailed knowledge of the process, such as mass or energy balance. This new approach was used at the Halden Man-Machine Laboratory of the OECD Halden Reactor Project. The performance of MOAS II, developed in G2 real-time expert system shell for the high-pressure preheaters of the NORS process, was tested against a variety of transient scenarios, including failures of control valves and sensors, and leakage of tubes of the preheaters. These tests showed that MOAS II successfully carried out its intended functions, i.e., quickly recognizing an occurring disturbance, correctly diagnosing its cause, and presenting advice on its control to the operator. The insights gained during the implementation are discussed

Genetic testing for BRCA1: effects of a randomised study of knowledge provision on interest in testing and long term test uptake; implications for the NICE guidelines.

Science.gov (United States)

Hall, Julia; Gray, Susan; A'Hern, Roger; Shanley, Susan; Watson, Maggie; Kash, Kathryn; Croyle, Robert; Eeles, Rosalind

2009-01-01

Interest in searching for mutations in BRCA1 and BRCA2 is high. Knowledge regarding these genes and the advantages and limitations of genetic testing is limited. It is unknown whether increasing knowledge about breast cancer genetic testing alters interest in testing. Three hundred and seventy nine women (260 with a family history of breast cancer; 119 with breast cancer) from The Royal Marsden NHS Foundation Trust were randomised to receive or not receive written educational information on cancer genetics. A questionnaire was completed assessing interest in BRCA1 testing and knowledge on breast cancer genetics and screening. Actual uptake of BRCA1 testing is reported with a six year follow-up. Eighty nine percent of women at risk of breast cancer and 76% of women with breast cancer were interested in BRCA1 testing (P testing, the families of 66% of the at risk group and 13% of the women with breast cancer would be eligible for testing (probability of BRCA1 mutation >or=20%). Within six years of randomisation, genetic testing was actually undertaken on 12 women, only 10 of whom would now be eligible, on the NICE guidelines. There is strong interest in BRCA1 testing. Despite considerable ignorance of factors affecting the inheritance of breast cancer, education neither reduced nor increased interest to undergo testing. The NICE guidelines successfully triage those with a high breast cancer risk to be managed in cancer genetics clinics.

Change of antibiotic susceptibility testing guidelines from CLSI to EUCAST: influence on cumulative hospital antibiograms.

Science.gov (United States)

Wolfensberger, Aline; Sax, Hugo; Weber, Rainer; Zbinden, Reinhard; Kuster, Stefan P; Hombach, Michael

2013-01-01

We studied whether the change in antibiotic susceptibility testing (AST) guidelines from CLSI to EUCAST influenced cumulative antibiograms in a tertiary care hospital in Switzerland. Antibiotic susceptibilities of non-duplicate isolates collected within a one-year period before (period A) and after (period B) changing AST interpretation from CLSI 2009 to EUCAST 1.3 (2011) guidelines were analysed. In addition, period B isolates were reinterpreted according to the CLSI 2009, CLSI 2013 and EUCAST 3.1 (2013) guidelines. The majority of species/drug combinations showed no differences in susceptibility rates comparing periods A and B. However, in some gram-negative bacilli, decreased susceptibility rates were observed when comparing CLSI 2009 with EUCAST 1.3 within period B: Escherichia coli / cefepime, 95.8% (CLSI 2009) vs. 93.1% (EUCAST 1.3), P=0.005; Enterobacter cloacae / cefepime, 97.0 (CLSI 2009) vs. 90.5% (EUCAST 1.3), P=0.012; Pseudomonas aeruginosa / meropenem, 88.1% (CLSI 2009) vs. 78.3% (EUCAST 1.3), P=0.002. These differences were still evident when comparing susceptibility rates according to the CLSI 2013 guideline with EUCAST 3.1 guideline. For P. aeruginosa and imipenem, a trend towards a lower antibiotic susceptibility rate in ICUs compared to general wards turned into a significant difference after the change to EUCAST: 87.9% vs. 79.8%, P=0.08 (CLSI 2009) and 86.3% vs. 76.8%, P=0.048 (EUCAST 1.3). The change of AST guidelines from CLSI to EUCAST led to a clinically relevant decrease of susceptibility rates in cumulative antibiograms for defined species/drug combinations, particularly in those with considerable differences in clinical susceptibility breakpoints between the two guidelines.

Guidelines for assessing the knowledge management maturity of organizations

Directory of Open Access Journals (Sweden)

C. J. Kruger

2007-11-01

Full Text Available In a recent article Kruger and Snyman hypothesized that progressions in knowledge management maturity (from a strategic perspective are directly related to an increased ability to speed up the strategic cycle of imitation, consolidation and innovation. The arguments proposed, however, neglected to supply the reader with a practical toolkit or even a roadmap (a time-related matrix, or questionnaire to successfully measure succession in knowledge management maturity. This article builds on the previous one and proposes a questionnaire consisting of six sections, containing 101 descriptive questions, to enable organizations to test and assess their knowledge management maturity empirically. The development of an instrument to measure knowledge management maturity required adhering to a research design that combined theoretical propositions with practical experimentation. As a point of departure, a knowledge management maturity matrix consisting of seven maturity levels was formulated. All questions contained within the matrix were benchmarked against a survey questionnaire developed by the public management service of the OECD (PUMA and were also pre-tested and validated. This process of refinement led to the formulation of the Knowledge Management Maturity Questionnaire. To avoid any taint of this research being based only on theoretical propositions, the questionnaire was tested by 178 master students of the University of Pretoria, South Africa, in nine different industries. The proposed questionnaire provides a bridge between theoretical propositions and practical usability, not only enabling knowledge management practitioners to assess the level of knowledge management maturity reached successfully but, more importantly, also serving as a guideline to institutionalize further and future knowledge management endeavours.

Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods.

Science.gov (United States)

Casati, S; Aschberger, K; Barroso, J; Casey, W; Delgado, I; Kim, T S; Kleinstreuer, N; Kojima, H; Lee, J K; Lowit, A; Park, H K; Régimbald-Krnel, M J; Strickland, J; Whelan, M; Yang, Y; Zuang, Valérie

2018-02-01

Skin sensitisation is the regulatory endpoint that has been at the centre of concerted efforts to replace animal testing in recent years, as demonstrated by the Organisation for Economic Co-operation and Development (OECD) adoption of five non-animal methods addressing mechanisms under the first three key events of the skin sensitisation adverse outcome pathway. Nevertheless, the currently adopted methods, when used in isolation, are not sufficient to fulfil regulatory requirements on the skin sensitisation potential and potency of chemicals comparable to that provided by the regulatory animal tests. For this reason, a number of defined approaches integrating data from these methods with other relevant information have been proposed and documented by the OECD. With the aim to further enhance regulatory consideration and adoption of defined approaches, the European Union Reference Laboratory for Alternatives to Animal testing in collaboration with the International Cooperation on Alternative Test Methods hosted, on 4-5 October 2016, a workshop on the international regulatory applicability and acceptance of alternative non-animal approaches, i.e., defined approaches, to skin sensitisation assessment of chemicals used in a variety of sectors. The workshop convened representatives from more than 20 regulatory authorities from the European Union, United States, Canada, Japan, South Korea, Brazil and China. There was a general consensus among the workshop participants that to maximise global regulatory acceptance of data generated with defined approaches, international harmonisation and standardisation are needed. Potential assessment criteria were defined for a systematic evaluation of existing defined approaches that would facilitate their translation into international standards, e.g., into a performance-based Test Guideline. Informed by the discussions at the workshop, the ICATM members propose practical ways to further promote the regulatory use and facilitate

In situ research and investigations in OECD countries

International Nuclear Information System (INIS)

1988-01-01

This report explains why deep geological disposal is the most favoured option for the disposal of high level waste and spent fuel, as well as some alpha bearing wastes. It also gives an overview of the main aim and elements of in-situ research and investigation activities in OECD countries, as well as of initiatives taken at an international level

An investigation on the determinants of carbon emissions for OECD countries: empirical evidence from panel models robust to heterogeneity and cross-sectional dependence.

Science.gov (United States)

Dogan, Eyup; Seker, Fahri

2016-07-01

This empirical study analyzes the impacts of real income, energy consumption, financial development and trade openness on CO2 emissions for the OECD countries in the Environmental Kuznets Curve (EKC) model by using panel econometric approaches that consider issues of heterogeneity and cross-sectional dependence. Results from the Pesaran CD test, the Pesaran-Yamagata's homogeneity test, the CADF and the CIPS unit root tests, the LM bootstrap cointegration test, the DSUR estimator, and the Emirmahmutoglu-Kose Granger causality test indicate that (i) the panel time-series data are heterogeneous and cross-sectionally dependent; (ii) CO2 emissions, real income, the quadratic income, energy consumption, financial development and openness are integrated of order one; (iii) the analyzed data are cointegrated; (iv) the EKC hypothesis is validated for the OECD countries; (v) increases in openness and financial development mitigate the level of emissions whereas energy consumption contributes to carbon emissions; (vi) a variety of Granger causal relationship is detected among the analyzed variables; and (vii) empirical results and policy recommendations are accurate and efficient since panel econometric models used in this study account for heterogeneity and cross-sectional dependence in their estimation procedures.

An Internal Audit Perspective on Differences between European Corporate Governance Codes and OECD Principles

OpenAIRE

Raluca Ivan

2015-01-01

The main purpose of this research is to realize an analysis from an internal audit perspective of European Corporate Governance Codes, in regards with Organization for Economic Cooperation and Development – OECD Principles of Corporate Governance. The research methodology used a classification of countries by legal regime, trying to obtain a global view over the differences between the European corporate governance codes and the OECD Principles provisions, from internal audit’s perspective. T...

The Role of the OECD and the EU in the Development of Labour Market Policy in the Czech Republic

Directory of Open Access Journals (Sweden)

Caroline Anne de la Porte

2009-12-01

Full Text Available This article analyses the role of the OECD through its “Jobs Strategy” and the European Union (EU through the “European Employment Strategy” in the development of macro-economic, employment and labour market policy in the Czech Republic. As a full member of the two organisations, the Czech Republic has been subject to their soft non-binding policy advice in the area of labour market reform. The OECD and EU policy models are similar, both insisting on growth-oriented macro-economic policy, supported by active labour market policies, an active and effective public employment service (PES and the de-regulation of labour markets. However, the OECD actively advocates private actor involvement in labour markets, while the EU insists on the role of the public sector. The inquisitive styles of the two organisations differ: the OECD has a decontextualised and quantified analysis of performance accompanied by a supportive in-depth qualitative analysis, while the EU has a more contextualised analysis, which is also more politicised. However, the EU’s policy is partially supported by European structural funds, while the OECD has no comparable instrument. Despite some differences in policy model and inquisitive style, both the OECD and the EU have given the same major policy recommendations over time to the Czech Republic, although the OECD has insisted more on de-regulation, whereas the EU has also emphasised worker security and anti-discrimination. In macro-economic policy, de-regulation and increasing flexibility on the labour market, the Czech Republic conforms with OECD and EU policy models and recommendations. The PES has been developed institutionally to fit both models. However, activation, shifts in expenditure from passive to active labour market policy, training and placement of the PES have not changed substantially since the Czech Republic became member of the EU, suggesting that the real impact of the OECD and the EU has been weak.

Golden Relics & Historical Standards: How the OECD is Expanding Global Education Governance through PISA for Development

Science.gov (United States)

Addey, Camilla

2017-01-01

Setting this paper against the backdrop of scholarly research on recent changes in the OECD's approach and workings in education, I analyse how the OECD has reinforced its infrastructural and epistemological global governance through the Programme for International Student Assessment (PISA) for Development (PISA-D). Drawing on qualitative data,…

Guidelines for inservice testing at nuclear power plants. Draft report for comment

International Nuclear Information System (INIS)

Campbell, P.

1993-11-01

In this report, the staff gives licensees guidelines for developing and implementing programs for the inservice testing of pumps and valves at commercial nuclear power plants. The report includes U.S. Nuclear Regulatory Commission (NRC) guidance and recommendations on inservice testing issues. The staff discusses the regulations, the components to be included in an inservice testing program, and the preparation and content of cold shutdown and refueling outage justifications and requests for relief from the American Society of Mechanical Engineers Code requirements. The staff also gives specific guidance on relief acceptable to the NRC and advises licensees in the use of this information for application at their facilities. The staff discusses the revised standard technical specifications for the inservice testing program requirements and gives guidance on the process a licensee may follow upon finding an instance of noncompliance with the Code

Ekonominio bendradarbiavimo ir plėtros organizacijos transakcijų kainodaros reguliavimas ir jo įtaka Lietuvai

OpenAIRE

Savickaitė, Kristina

2008-01-01

The article deals with fundamentals of transfer pricing regulation by the OECD and Lithuania. Firstly, the Model Convention of the OECD is presented. Secondly, the rules of the OECD Transfer Pricing Guidelines for Multinational and Tax Administrations (hereinafter the Guidelines) and Lithuanian legal acts on transfer pricing are analysed and the comparison of them is being made. OECD issued the first Model Double Taxation Convention (hereinafter the MDTC) in 1963, which Was reviewed on severa...

Evaluation of hypothesized adverse outcome pathway linking thyroid peroxidase inhibition to fish early life stage toxicity

Science.gov (United States)

There is an interest in developing alternatives to the fish early-life stage (FELS) test (OECD test guideline 210), for predicting adverse outcomes (e.g., impacts on growth and survival) using less resource-intensive methods. Development and characterization of adverse outcome pa...

Original Research Original Research

African Journals Online (AJOL)

RAGHAVENDRA

local market, Mysore and was authenticated by Dr. Nagamani ... Limit test was carried out in accordance to the OECD guideline ... by Tukey's multiple comparison test. p<0.05 was ..... acid B on an Aβ25–35 peptide-induced mouse model of.

The borderline range of toxicological methods

NARCIS (Netherlands)

Leontaridou, Maria; Urbisch, Daniel; Kolle, Susanne N.; Ott, Katharina; Mulliner, Denis S.; Gabbert, Silke; Landsiedel, Robert

2017-01-01

Test methods to assess the skin sensitization potential of a substance usually use threshold criteria to dichotomize continuous experimental read-outs into yes/no conclusions. The threshold criteria are prescribed in the respective OECD test guidelines and the conclusion is used for regulatory

Globalization and Social Justice in OECD Countries

OpenAIRE

Björn Kauder; Niklas Potrafke

2015-01-01

Social justice is a topic of importance to social scientists and also political decision makers. We examine the relationship between globalization and social justice as measured by a new indicator for 31 OECD countries. The results show that countries that experienced rapid globalization enjoy social justice. When the KOF index of globalization increases by one standard deviation, the social justice indicator increases by about 0.4 points (on a scale from 1 to 10). The policy implication is t...

IAEA/NEA incident reporting system (IRS). Reporting guidelines. Feedback from safety related operating experience for nuclear power plants

International Nuclear Information System (INIS)

1998-01-01

The Incident Reporting System (IRS) is an international system jointly operated by the International Atomic Energy Agency (IAEA) and the Nuclear Energy Agency of the Organisation for Economic Cooperation and Development (OECD/NEA). The fundamental objective of the IRS is to contribute to improving the safety of commercial nuclear power plants (NPPs) which are operated worldwide. This objective can be achieved by providing timely and detailed information on both technical and human factors related to events of safety significance which occur at these plants. The purpose of these guidelines, which supersede the previous IAEA Safety Series No. 93 (Part II) and the NEA IRS guidelines, is to describe the system and to give users the necessary background and guidance to enable them to produce IRS reports meeting a high standard of quality while retaining the high efficiency of the system expected by all Member States operating nuclear power plants. These guidelines have been jointly developed and approved by the NEA/IAEA

Peptide bond-forming reagents HOAt and HATU are not mutagenic in the bacterial reverse mutation test.

Science.gov (United States)

Nicolette, John; Neft, Robin E; Vanosdol, Jessica; Murray, Joel

2016-04-01

The peptide bond-forming reagents 1-hydroxy-7-azabenzotriazole (HOAt, CAS 39968-33-7) and O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HATU, CAS 148893-10-1) either have structural alerts, unclassified features or are considered out of domain when evaluated for potential mutagenicity with in silico programs DEREK and CaseUltra. Since they are commonly used reagents in pharmaceutical drug syntheses, they may become drug substance or drug product impurities and would need to be either controlled to appropriately safe levels or tested for mutagenicity. Both reagents were tested in the bacterial reverse mutation (Ames) test at Covance, under GLP conditions, following the OECD test guideline and ICH S2(R1) recommendations and found to be negative. Our data show that HOAt and HATU-common pharmaceutical synthesis reagents-are not mutagenic, and can be treated as ordinary drug impurities. © 2016 Wiley Periodicals, Inc.

EPA's Role with the Organization for Economic Cooperation and Development (OECD)

Science.gov (United States)

The Organization for Economic Cooperation and Development (OECD) brings together the governments of countries committed to democracy and the market economy from around the world to support sustainable economic growth.

Procedure guideline for radioiodine test. Version; Verfahrensanweisung zum Radioiodtest. Version 2

Energy Technology Data Exchange (ETDEWEB)

Dietlein, M.; Dressler, J.; Leisner, B.; Reiners, C.; Schicha, H. [Deutsche Gesellschaft fuer Nuklearmedizin (DGN) (Germany); Eschner, W.; Lassmann, M. [Deutsche Gesellschaft fuer Nuklearmedizin (DGN) (Germany); Deutsche Gesellschaft fuer Medizinische Physik (DGMP) (Germany)

2003-06-01

The version 2 of the procedure guideline for radioiodine test is an update of the guideline published in 1999. The following statements were added or modified: The procedure guideline discusses the pros and cons of a single measurement or of repeated measurements of the iodine-131 uptake and their optimal timing. Different formulas are described when one, two or three values of the radioiodine kinetic are available. The probe with a sodium iodide crystal, alternative or additionally the gamma-camera using the ROI-technique are instrumentations for the measurement of iodine-131 uptake. A possible source of error is an inappropriate measurement (sonography) of the target volume. The patients' preparation includes the withdrawal of antithyroid drugs 2-3 days before radioiodine administration. The patient has to avoid iodine-containing medication and the possibility of additives of iodide in vitamin- or electrolyte-supplementation has to be considered. (orig.) [German] Mit der Version 2 der Verfahrensanweisung zum Radioiodtest wird die in 1999 publizierte Verfahrensanweisung aktualisiert. Ergaenzungen und Modifikationen betreffen die notwendige Anzahl und die Zeitintervalle der Iod-131-Uptake-Messungen. Diskutiert werden die Argumente fuer die ein- oder mehrmalige Uptake-Messung. Berechnungsformeln fuer ein, zwei und drei Messpunkte werden angegeben. Als Messgeraete koennen die Uptake-Messsonde, alternativ oder zusaetzlich die Gammakamera mit ROI-Technik zum Einsatz kommen. Fehler bei der Volumetrie (Sonographie) des Zielvolumens gehen unmittelbar in die Berechnung der Therapieaktivitaet ein. Zur Vorbereitung der Patienten wird ein Absetzen der thyreostatischen Medikation 2 bis 3 Tage vor dem Radioiodtest empfohlen. Moeglich Iod(id) zusaetze in Multivitamin- und Spurenelementkombinationen sollten bedacht werden. (orig.)

Change of antibiotic susceptibility testing guidelines from CLSI to EUCAST: influence on cumulative hospital antibiograms.

Directory of Open Access Journals (Sweden)

Aline Wolfensberger

Full Text Available OBJECTIVE: We studied whether the change in antibiotic susceptibility testing (AST guidelines from CLSI to EUCAST influenced cumulative antibiograms in a tertiary care hospital in Switzerland. METHODS: Antibiotic susceptibilities of non-duplicate isolates collected within a one-year period before (period A and after (period B changing AST interpretation from CLSI 2009 to EUCAST 1.3 (2011 guidelines were analysed. In addition, period B isolates were reinterpreted according to the CLSI 2009, CLSI 2013 and EUCAST 3.1 (2013 guidelines. RESULTS: The majority of species/drug combinations showed no differences in susceptibility rates comparing periods A and B. However, in some gram-negative bacilli, decreased susceptibility rates were observed when comparing CLSI 2009 with EUCAST 1.3 within period B: Escherichia coli / cefepime, 95.8% (CLSI 2009 vs. 93.1% (EUCAST 1.3, P=0.005; Enterobacter cloacae / cefepime, 97.0 (CLSI 2009 vs. 90.5% (EUCAST 1.3, P=0.012; Pseudomonas aeruginosa / meropenem, 88.1% (CLSI 2009 vs. 78.3% (EUCAST 1.3, P=0.002. These differences were still evident when comparing susceptibility rates according to the CLSI 2013 guideline with EUCAST 3.1 guideline. For P. aeruginosa and imipenem, a trend towards a lower antibiotic susceptibility rate in ICUs compared to general wards turned into a significant difference after the change to EUCAST: 87.9% vs. 79.8%, P=0.08 (CLSI 2009 and 86.3% vs. 76.8%, P=0.048 (EUCAST 1.3. CONCLUSIONS: The change of AST guidelines from CLSI to EUCAST led to a clinically relevant decrease of susceptibility rates in cumulative antibiograms for defined species/drug combinations, particularly in those with considerable differences in clinical susceptibility breakpoints between the two guidelines.

Use of the National Committee for Clinical Laboratory Standards Guidelines for Disk Diffusion Susceptibility Testing in New York State Laboratories

Science.gov (United States)

Kiehlbauch, Julia A.; Hannett, George E.; Salfinger, Max; Archinal, Wendy; Monserrat, Catherine; Carlyn, Cynthia

2000-01-01

Accurate antimicrobial susceptibility testing is vital for patient care and surveillance of emerging antimicrobial resistance. The National Committee for Clinical Laboratory Standards (NCCLS) outlines generally agreed upon guidelines for reliable and reproducible results. In January 1997 we surveyed 320 laboratories participating in the New York State Clinical Evaluation Program for General Bacteriology proficiency testing. Our survey addressed compliance with NCCLS susceptibility testing guidelines for bacterial species designated a problem (Staphylococcus aureus and Enterococcus species) or fastidious (Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria gonorrhoeae) organism. Specifically, we assessed compliance with guidelines for inoculum preparation, medium choice, number of disks per plate, and incubation conditions for disk diffusion tests. We also included length of incubation for S. aureus and Enterococcus species. We found overall compliance with the five characteristics listed above in 80 of 153 responding laboratories (50.6%) for S. aureus and 72 of 151 (47.7%) laboratories for Enterococcus species. The most common problem was an incubation time shortened to less than 24 h. Overall compliance with the first four characteristics was reported by 92 of 221 (41.6%) laboratories for S. pneumoniae, 49 of 163 (30.1%) laboratories for H. influenzae, and 11 of 77 (14.3%) laboratories for N. gonorrhoeae. Laboratories varied from NCCLS guidelines by placing an excess number of disks per plate. Laboratories also reported using alternative media for Enterococcus species, N. gonorrhoeae, and H. influenzae. This study demonstrates a need for education among clinical laboratories to increase compliance with NCCLS guidelines. PMID:10970381

The periodic safety review of nuclear power plants. Practices in OECD countries

International Nuclear Information System (INIS)

1992-01-01

This report gives an overview of the regulatory concepts and practices for the periodic safety review of nuclear power plants in OECD countries with nuclear power programmes. The statutory bases for such reviews, their objectives and the processes adopted are summarised against the background of each country's regulatory practices. Although periodic safety reviews are now, or will soon be, part of the regulatory process in the majority of countries, the national approaches to these reviews still differ considerably. This report includes numerous examples of the different concepts and practices in OECD countries, thereby illustrating the variety of ways adopted to reach the common goal of maintaining and improving nuclear safety

OECD/NEA multi-lateral cooperation in the area of structural integrity & aging management

Energy Technology Data Exchange (ETDEWEB)

Breest, A. [Nuclear Energy Agency, Issy-les-Moulineaux (France); Gott, K. [MATSAFE AB, Stockholm (Sweden); Lydell, B. [SIGMA-PHASE Inc., Vail, AZ (United States); Riznic, J. [Canadian Nuclear Safety Commission, Ottawa, ON (Canada)

2014-07-01

Several OECD Member Countries have agreed to establish the OECD/NEA 'Component Operational Experience, Degradation & Ageing Programme' (CODAP) to encourage multilateral co-operation in the collection and analysis of data relating to degradation and failure of metallic piping and non-piping metallic passive components in commercial nuclear power plants. The scope of the data collection includes service-induced wall thinning, part through-wall cracks, through-wall cracks with and without active leakage, and instances of significant degradation of metallic passive components, including piping pressure boundary integrity. The OECD/NEA Committee on the Safety of Nuclear Installations (CSNI) acts as an umbrella committee of the Project. CODAP is the continuation of the 2002-2011 'OECD/NEA Pipe Failure Data Exchange Project' (OPDE) and the Stress Corrosion Cracking Working Group of the 2006-2010 'OECD/NEA SCC and Cable Ageing project' (SCAP). OPDE was formally launched in May 2002. Upon completion of the 3rd Term (May 2011), the OPDE project was officially closed to be succeeded by CODAP. SCAP was enabled by a voluntary contribution from Japan. It was formally launched in June 2006 and officially closed with an international workshop held in Tokyo in May 2010. Majority of the Member Organizations of the two projects were the same, often being represented by the same person. In May 2011, thirteen countries signed the CODAP 1st Term agreement (Canada, Chinese Taipei, Czech Republic, Finland, France, Germany, Korea (Republic of), Japan, Slovak Republic, Spain, Sweden, Switzerland and United States of America). The 1st Term (2011-2014) work plan includes the preparation of Topical Reports to foster technical cooperation and to deepen the understanding of national differences in ageing management. The Topical Reports constitute CODAP Event Database and Knowledge Base insights reports and as such act as portals for future in-depth studies of

Coal consumption and economic growth: Evidence from a panel of OECD countries

International Nuclear Information System (INIS)

Apergis, Nicholas; Payne, James E.

2010-01-01

This study examines the relationship between coal consumption and economic growth for 25 OECD countries within a multivariate panel framework over period 1980-2005. The panel cointegration test indicates there is a long-run equilibrium relationship between real GDP, coal consumption, real gross fixed capital formation, and the labor force. The respective coefficients for real gross fixed capital formation and the labor force are positive and statistically significant whereas the coefficient for coal consumption is negative and statistically significant. The results of the panel vector error correction model reveal bidirectional causality between coal consumption and economic growth in both the short- and long-run; however, the bidirectional causality in the short-run is negative.

JANNAF "Test and Evaluation Guidelines for Liquid Rocket Engines": Status and Application

Science.gov (United States)

Parkinson, Douglas; VanLerberghe, Wayne M.; Rahman, Shamim A.

2017-01-01

For many decades, the U.S. rocket propulsion industrial base has performed remarkably in developing complex liquid rocket engines that can propel critical payloads into service for the nation, as well as transport people and hardware for missions that open the frontiers of space exploration for humanity. This has been possible only at considerable expense given the lack of detailed guidance that captures the essence of successful practices and knowledge accumulated over five decades of liquid rocket engine development. In an effort to provide benchmarks and guidance for the next generation of rocket engineers, the Joint Army Navy NASA Air Force (JANNAF) Interagency Propulsion Committee published a liquid rocket engine (LRE) test and evaluation (T&E) guideline document in 2012 focusing on the development challenges and test verification considerations for liquid rocket engine systems. This document has been well received and applied by many current LRE developers as a benchmark and guidance tool, both for government-driven applications as well as for fully commercial ventures. The USAF Space and Missile Systems Center (SMC) has taken an additional near-term step and is directing activity to adapt and augment the content from the JANNAF LRE T&E guideline into a standard for potential application to future USAF requests for proposals for LRE development initiatives and launch vehicles for national security missions. A draft of this standard was already sent out for review and comment, and is intended to be formally approved and released towards the end of 2017. The acceptance and use of the LRE T&E guideline is possible through broad government and industry participation in the JANNAF liquid propulsion committee and associated panels. The sponsoring JANNAF community is expanding upon this initial baseline version and delving into further critical development aspects of liquid rocket propulsion testing at the integrated stage level as well as engine component level, in

Financial Inequity in Basic Education in Selected OECD Countries

Science.gov (United States)

Zhang, Yu; Mizunoya, Suguru; You, You; Tsang, Mun

2011-01-01

This is a study of financial disparities in primary and secondary education in OECD countries that have a relatively large population and a school finance system with decentralized features. These countries include the United States, Britain, Australia, Spain, Canada, and Japan. There are two major research questions: What are the trends in…

Taxation and Skills. OECD Tax Policy Studies. No. 24

Science.gov (United States)

OECD Publishing, 2017

2017-01-01

This Tax Policy Study on Taxation and Skills examines how tax policy can encourage skills development in OECD countries. This study also assesses the returns to tertiary and adult education and examines how these returns are shared between governments and students. The study builds indicators that examine incentives for individuals and governments…

How did the economic recession (2008-2010) influence traffic fatalities in OECD-countries?

Science.gov (United States)

Wegman, Fred; Allsop, Richard; Antoniou, Constantinos; Bergel-Hayat, Ruth; Elvik, Rune; Lassarre, Sylvain; Lloyd, Daryl; Wijnen, Wim

2017-05-01

This paper presents analyses of how the economic recession that started in 2008 has influenced the number of traffic fatalities in OECD countries. Previous studies of the relationship between economic recessions and changes in the number of traffic fatalities are reviewed. Based on these studies, a causal diagram of the relationship between changes of the business cycle and changes in the number of traffic fatalities is proposed. This causal model is tested empirically by means of multivariate analyses and analyses of accident statistics for Great Britain and Sweden. Economic recession, as indicated both by slower growth of, or decline of gross national product, and by increased unemployment is associated with an accelerated decline in the number of traffic fatalities, i.e. a larger decline than the long-term trend that is normal in OECD countries. The principal mechanisms bringing this about are a disproportionate reduction of driving among high-risk drivers, in particular young drivers and a reduction of fatality rate per kilometre of travel, probably attributable to changes in road user behaviour that are only partly observable. The total number of vehicle kilometres of travel did not change very much as a result of the recession. The paper is based on an ITF-report that presents the analyses in greater detail. Copyright © 2017 Elsevier Ltd. All rights reserved.

Renewable energy consumption and economic growth: Evidence from a panel of OECD countries

International Nuclear Information System (INIS)

Apergis, Nicholas; Payne, James E.

2010-01-01

This study examines the relationship between renewable energy consumption and economic growth for a panel of twenty OECD countries over the period 1985-2005 within a multivariate framework. Given the relatively short span of the time series data, a panel cointegration and error correction model is employed to infer the causal relationship. The heterogeneous panel cointegration test reveals a long-run equilibrium relationship between real GDP, renewable energy consumption, real gross fixed capital formation, and the labor force with the respective coefficients positive and statistically significant. The Granger-causality results indicate bidirectional causality between renewable energy consumption and economic growth in both the short- and long-run.

RE-EXAMINATION OF WAGNER’S LAW FOR OECD COUNTRIES

Directory of Open Access Journals (Sweden)

KORHAN GOKMENOGLU

2013-02-01

Full Text Available This paper investigates the relationship between government spending and economic growth. Economictheory generally expects a negative relationship between these variables for rich countries with large public sectors.However, empirical studies often cannot find a robust negative relationship and have provided mixed empiricalevidence. In the case of the relationship between public expenditure and economic growth it appears thatspecification of econometric methods, data selection and time span could affect the findings and lead to contradictoryconclusions. This paper utilizes a panel of cross-sectional and time series data for 16 OECD countries over the 1995-2010 periods to reexamine the relationship between government spending and economic growth by conductingeconometric panel study. We investigate the unit root properties and cointegration, long-run economic relationship,between government expenditure and economic growth to test the validity of Wagner’s Law. Our findings indicate thatgovernment spending exerts a positive and significant influence on economic growth and provide evidence for thevalidity of Wagner’s law.

Development of acute exposure guideline levels for airborne exposures to hazardous substances.

Science.gov (United States)

Krewski, Daniel; Bakshi, Kulbir; Garrett, Roger; Falke, Ernest; Rusch, George; Gaylor, David

2004-04-01

Hazardous substances can be released into the atmosphere due to industrial and transportation accidents, fires, tornadoes, earthquakes, and terrorists, thereby exposing workers and the nearby public to potential adverse health effects. Various enforceable guidelines have been set by regulatory agencies for worker and ambient air quality. However, these exposure levels generally are not applicable to rare lifetime acute exposures, which possibly could occur at high concentrations. Acute exposure guideline levels (AEGLs) provide estimates of concentrations for airborne exposures for an array of short durations that possibly could cause mild (AEGL-1), severe, irreversible, potentially disabling adverse health effects (AEGL-2), or life threatening effects (AEGL-3). These levels can be useful for emergency responders and planners in reducing or eliminating potential risks to the public. Procedures and methodologies for deriving AEGLs are reviewed in this paper that have been developed in the United States, with direct input from international representatives of OECD member-countries, by the National Advisory Committee for Acute Exposure Guidelines for Hazardous Substances and reviewed by the National Research Council. Techniques are discussed for the extrapolation of effects across different exposure durations. AEGLs provide a viable approach for assisting in the prevention, planning, and response to acute airborne exposures to toxic agents.

OECD/NEA activities on the safety of new reactors

International Nuclear Information System (INIS)

Reig, Javier

2010-01-01

The Nuclear Energy Agency, a member of the OECD family, has as mission, in line with the overall aim of the OECD, to assist Agency's member countries in maintaining and further developing through international cooperation, the scientific, technological and legal bases for a safe, environmentally friendly and economic use of nuclear energy for peaceful purposes. Our members include very advanced nuclear countries and represent a big part of the world's nuclear capacity. In addition, we have a well established and formal relationship with the Russian Federation and the IAEA. Two years ago, the NEA celebrated its 50th anniversary of providing assistance to its member countries in supporting the safe use of nuclear power. Nuclear power will remain a key part of the energy mix for many decades to come and, as such, the NEA looks forward to continuing its value-adding work in the field of nuclear power. Korea joined the NEA in 24 May, 1993. While the NEA is satisfied that we have in place an effective process of work, we are always looking for ways to improve. This is the reason why we have since 1999 a series of strategic plans in order to better focus on the objectives that member countries assign to the Agency for meeting the economical, environmental and societal challenges of the coming years. The important changes that have occurred in the energy and nuclear landscapes, as well as in the OECD framework, are the basis for these revisions insofar as they influence the NEA's role and activities. We are now completing the process for the new Strategic Plan which will apply from 2011 to 2017. Nuclear safety and regulation is and will continue to be the first priority of the Agency. The NEA will assist member countries to continue sharing information, best practices and lessons learned to enhance nuclear safety worldwide

Labour Taxation in Poland Compared to the Other OECD Countries

Directory of Open Access Journals (Sweden)

Kryńska Elżbieta

2014-09-01

Full Text Available Celem opracowania jest identyfikacja wysokości i zróżnicowania opodatkowania pracy, wyrażanego poprzez tzw. klin podatkowy, w Polsce na tle krajów OECD. Identyfikacji tej dokonano na podstawie analizy danych statystycznych zgromadzonych w bazie OECD obejmujących lata 2000-2012. W opracowaniu dokonano interpretacji pojęć kluczowych, takich jak opodatkowanie pracy, klin podatkowy i pozapłacowe koszty pracy. W dalszej części syntetycznie omówiono ustalenia teoretyczne i wyniki badań empirycznych dotyczących skutków opodatkowania pracy dla funkcjonowania rynku pracy, a zwłaszcza jego wpływ na zatrudnienie i bezrobocie. Badania własne objęły analizę porównawczą wielkości klina podatkowego w różnych typach gospodarstw domowych w Polsce i pozostałych krajach OECD w latach 2000-2012. Najważniejszą konstatacją wynikającą z analiz jest, iż w Polsce opodatkowanie pracy w zbyt małym stopniu uwzględnia sytuację materialną osób nisko zarabiających oraz mających nautrzymaniu dzieci. Wyniki przeprowadzonych badań stały się podstawą sformułowania wniosków syntetycznych i rekomendacji dla Polski. Zasugerowano w nich przede wszystkim, by rozważono selektywne obniżenie pozapłacowych kosztów pracy osób nisko zarabiających oraz obciążonych obowiązkami rodzinnymi.

Overview of the burnup credit activities at OECD/NEA/NSC

International Nuclear Information System (INIS)

Brady Raap, M.C.; Nomura, Y.; Sartori, E.

2001-01-01

This article summarizes activities of the OECD/NEA Burnup Credit Expert Panel, a subordinate group to the Working Party on Nuclear Criticality Safety (WPNCS). The WPNCS of the OECD/NEA coordinates and carries out work in the domain of criticality safety at the international level. Particular attention is devoted to establishing sound databases required in this area and to addressing issues of high relevance such as burnup credit. The activities of the expert panel are aimed toward improving safety and identifying economic solutions to issues concerning the back-end of the fuel cycle. The main objective of the activities of the OECD/NEA Burnup Credit Expert Panel is to demonstrate that the available criticality safety calculational tools are appropriate for application to burned fuel systems and that a reasonable safety margin can be established. The method established by the expert panel for investigating the physics and predictability of burnup credit is based on the specification and comparison of calculational benchmark problems. A wide range of fuel types, including PWR, BWR, MOX, and VVER fuels, has been or are being addressed by the expert panel. The objective and status of each of these benchmark problems is reviewed in this article. It is important to note that the focus of the expert panel is the comparison of the results submitted by each participant to assess the capability of commonly used code systems, not to quantify the physical phenomena investigated in the comparisons or to make recommendations for licensing action. (author)

Appraisal of within- and between-laboratory reproducibility of non-radioisotopic local lymph node assay using flow cytometry, LLNA:BrdU-FCM: comparison of OECD TG429 performance standard and statistical evaluation.

Science.gov (United States)

Yang, Hyeri; Na, Jihye; Jang, Won-Hee; Jung, Mi-Sook; Jeon, Jun-Young; Heo, Yong; Yeo, Kyung-Wook; Jo, Ji-Hoon; Lim, Kyung-Min; Bae, SeungJin

2015-05-05

Mouse local lymph node assay (LLNA, OECD TG429) is an alternative test replacing conventional guinea pig tests (OECD TG406) for the skin sensitization test but the use of a radioisotopic agent, (3)H-thymidine, deters its active dissemination. New non-radioisotopic LLNA, LLNA:BrdU-FCM employs a non-radioisotopic analog, 5-bromo-2'-deoxyuridine (BrdU) and flow cytometry. For an analogous method, OECD TG429 performance standard (PS) advises that two reference compounds be tested repeatedly and ECt(threshold) values obtained must fall within acceptable ranges to prove within- and between-laboratory reproducibility. However, this criteria is somewhat arbitrary and sample size of ECt is less than 5, raising concerns about insufficient reliability. Here, we explored various statistical methods to evaluate the reproducibility of LLNA:BrdU-FCM with stimulation index (SI), the raw data for ECt calculation, produced from 3 laboratories. Descriptive statistics along with graphical representation of SI was presented. For inferential statistics, parametric and non-parametric methods were applied to test the reproducibility of SI of a concurrent positive control and the robustness of results were investigated. Descriptive statistics and graphical representation of SI alone could illustrate the within- and between-laboratory reproducibility. Inferential statistics employing parametric and nonparametric methods drew similar conclusion. While all labs passed within- and between-laboratory reproducibility criteria given by OECD TG429 PS based on ECt values, statistical evaluation based on SI values showed that only two labs succeeded in achieving within-laboratory reproducibility. For those two labs that satisfied the within-lab reproducibility, between-laboratory reproducibility could be also attained based on inferential as well as descriptive statistics. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Best-practices guidelines for L2PSA development and applications. Volume 2 - Best practices for the Gen II PWR, Gen II BWR L2PSAs. Extension to Gen III reactors

International Nuclear Information System (INIS)

Raimond, E.; Durin, T.; Rahni, N.; Meignen, R.; Cranga, M.; Pichereau, F.; Bentaib, A.; Guigueno, Y.; Loeffler, H.; Mildenberger, O.; Lajtha, G.; Santamaria, C.S.; Dienstbier, J.; Rydl, A.; Holmberg, J.E.; Lindholm, I.; Maennistoe, I.; Pauli, E.M.; Dirksen, G.; Grindon, L.; Peers, K.; Hulqvist, G.; Parozzi, F.; Polidoro, F.; Cazzoli, E.; Vitazkova, J.; Burgazzi, L.; Oury, L.; Ngatchou, C.; Siltanen, S.; Niemela, I.; Routamo, T.; Helstroem, P.; Bassi, C.; Brinkman, H.; Seidel, A.; Schubert, B.; Wohlstein, R.; Guentay, S.; Vincon, L.

2010-01-01

The objective of this coordinated action was to develop best practice guidelines for the performance of Level 2 PSA methodologies with a view of harmonisation at EU level and to allow meaningful and practical uncertainty evaluations in a Level 2 PSA. Specific relationships with community in charge of nuclear reactor safety (utilities, safety authorities, vendors, and research or services companies) have been established in order to define the current needs in terms of guidelines for level 2 PSA development and applications. An international workshop was organised in Hamburg, with the support of VATTENFALL, in November 2008. The level 2 PSA experts from the ASAMPSA2 project partners have proposed some guidelines for the development and application of L2PSA based on their experience and on information available from international cooperation (EC Severe Accident network of Excellence - SARNET, IAEA standards, OECD-NEA publications and workshop) or open literature. The number of technical issues addressed in the guideline is very large and all are not covered with the same relevancy in the first version of the guideline. This version is submitted for external review in November 2010 by severe accident experts and PSA, especially, from SARNET and OECD-NEA members. The feedback of the external review will be dis cussed during an international open works hop planned in March 2011 and all outcomes will be taken into consideration in the final version of this guideline (June 2011). The guideline includes 3 volumes: - Volume 1 - General considerations on L2PSA. - Volume 2 - Technical recommendations for Gen II and III reactors. - Volume 3 - Specific considerations for future reactor (Gen IV). The recommendations formulated in the guideline should not be considered as 'mandatory' but should help the L2PSA developers to achieve high quality studies with limited time and resources. It may also help the L2PSA reviewers by positioning one specific study in comparison with some

Acute and Sub-acute Toxicity Profile of Aqueous Leaf Extract of ...

African Journals Online (AJOL)

information on the safety/toxicity of the aqueous extract of Nymphaea .... automatic chemistry analyzer (Abaxis Inc. Union. City, CA .... play central role in gaseous exchange and inter- compartmental .... OECD guidelines for testing of chemicals ...

Review of the OECD specialist meeting on continuous monitoring techniques for assuring coolant circuit integrity

International Nuclear Information System (INIS)

Thie, J.A.

1986-01-01

This article summarizes the OECD Specialist Meeting on Continuous Monitoring Techniques for Assuring Coolant Circuit Integrity held August 12-14, 1985, in London. The conference was organized by the Organization for Economic Cooperation and Development's (OECD's) Committee on the Safety for Nuclear Installations and hosted by Her Majesty's Nuclear Installation Inspectorate at King's College. Many other conferences have addressed analysis and inspection approaches to ensuring primary-system integrity, but the OECD meeting was structured to pay attention to the continuous monitoring approach - possibly the first conference to be so designed. The specific technologies represented were vibrations, noise (i.e., random fluctuations in signals), leaks, acoustic emission, and cyclic fatigue. Although water reactors dominate the papers, all reactor types were included. A diverse group of about 50 attendees from 11 countries participated, including representatives from utilities, suppliers, regulators, and researchers

Scale resolved simulations of the OECD/NEA–Vattenfall T-junction benchmark

Energy Technology Data Exchange (ETDEWEB)

Höhne, Thomas, E-mail: t.hoehne@hzdr.de

2014-04-01

Mixing of fluids in T-junction geometries is of significant interest for nuclear safety research. The most prominent example is the thermal striping phenomena in piping T-junctions, where hot and cold streams join and turbulently mix, however not completely or not immediately at the T-junction. This result in significant temperature fluctuations near the piping wall, either at the side of the secondary pipe branch or at the opposite side of the main branch pipe. The wall temperature fluctuation can cause cyclical thermal stresses and subsequently fatigue cracking of the wall. Thermal mixing in a T-junction has been studied for validation of CFD-calculations. A T-junction thermal mixing test was carried out at the Älvkarleby Laboratory of Vattenfall Research and Development (VRD) in Sweden. Data from this test have been reserved specifically for a OECD CFD benchmark exercise. The computational results show that RANS fail to predict a realistic mixing between the fluids. The results were significantly better with scale-resolving methods such as LES, showing fairly good predictions of the velocity field and mean temperatures. The calculation predicts also similar fluctuations and frequencies observed in the model test.

Interpretive criteria for mupirocin susceptibility testing of Staphylococcus spp. using CLSI guidelines.

LENUS (Irish Health Repository)

Creagh, S

2012-02-03

Mupirocin is an antimicrobial agent commonly used to treat staphylococcal infection or to eliminate persistent carriage. To date, interpretive criteria have not been established to define susceptibility or resistance when performing mupirocin susceptibility testing. In this evaluation, using CLSI guidelines, a total of 502 staphylococci comprising 219 methicillin-sensitive Staphylococcus aureus, 222 methicillin-resistant S. aureus and 61 coagulase-negative staphylococci are tested by broth microdilution, disc diffusion and E-test. Disc diffusion using 5 microg mupirocin discs was found to be a reliable method to distinguish susceptible and resistant strains. Minimum inhibitory concentration (MIC) determination was required to differentiate low-level and high-level resistance to mupirocin. E-test was found to be an accurate alternative to broth microdilution for the routine determination of MIC values of staphylococci to mupirocin. Broth microdilution and disc-diffusion results were plotted on a scattergram, and error rates were calculated. No errors were found using susceptibility criteria of < 4 microg\\/mL (MIC) and > 19 mm (zone diameter).

Effects of zerumbone on cisplatin-induced clastogenesis in Sprague ...

African Journals Online (AJOL)

Administrator

2011-06-20

Jun 20, 2011 ... bol ester-induced papilloma formation in mouse skin which is another indication of its ... zerumbet plant. The rhizomes were obtained from the wet market in ... erythrocyte micronucleus test), guideline No. 474 (OECD 1997).

Comparing the OECD's and Norway's Orientation to Equity in Their Teacher Education Policies--Teacher Autonomy under Attack?

Science.gov (United States)

Haugen, Cecilie Ronning

2013-01-01

More and more nations are losing the ability to control their education systems. OECD is an important premise provider for educational policymaking championing a neoliberal agenda. With the aim to investigate the impact the OECD may have on national policymaking, this paper compares their recent teacher education policies with those of Norway. The…

Training guidelines in non-destructive testing techniques. 1991 edition

International Nuclear Information System (INIS)

1991-10-01

Non-destructive testing methods (NDT), by their very nature, allow components to be fully examined for properties or flaws without interfering with their usefulness. This grouping of inspection methods has grown from a handful of primitive techniques practised by artists to a widely known discipline which is an essential part of quality control, largely as a result of the standards demanded by the nuclear and aerospace industries. Recognizing the need for an international publication of NDT training syllabi, the IAEA Consultants Meeting on ''Qualification and Certification of NDT Personnel'' (Milan, 20-21 May 1986), recommended that the Agency publish the guidelines developed by Regional Working Group of the Latin America and Caribbean project. It was first issued in English in 1987 and has now been re-edited in English and Spanish and enlarged by the addition of programmes for other techniques

Man-machine systems research at the OECD Halden reactor project

International Nuclear Information System (INIS)

Owre, F.; Bjorlo, T.J.; Haugset, K.

1994-01-01

The OECD Halden Reactor Project is a jointly financed research programme under the auspices of the OECD - Nuclear Energy Agency with fifteen participating countries. One of the main research topics focuses on man-machine systems. Particular attention is paid to the operator's tasks in the reactor control room environment. The overall objective of the research in this field is to provide a basis for improving today's control rooms through the introduction of computer-based solutions for the effective and safe execution of surveillance and control functions in normal as well as off-normal plant situations. The programme comprises four main activities: the verification and validation of safety critical software systems; man-machine interaction research emphasizing improvements in man-machine interfaces on the basis of human factors studies; computerised operator support systems assisting the operator in fault detection/diagnosis and planning of control actions; and control room development providing a basis for retrofitting of existing control rooms and for the design of advanced concepts

The Environmental Kuznets Curve. An empirical analysis for OECD countries

Energy Technology Data Exchange (ETDEWEB)

Georgiev, E.

2008-09-15

This paper tests the Environmental Kuznets Curve hypothesis for four local (SOx, NOx, CO, VOC) and two global (CO2, GHG) air pollutants. Using a new panel data set of thirty OECD countries, the paper finds that the postulated inverted U-shaped relationship between income and pollution does not hold for all gases. A meaningful Environmental Kuznets Curve exists only for CO, VOC and NOx, where for CO2 the curve is monotonically increasing. For GHG there is indication of an inverted U-shaped relationship between income and pollution, but still most countries are on the increasing path of the curve and hence the future development of the curve is uncertain. For SOx it was found that emissions follow an U-shaped curve. Based on the empirical results, the paper concludes that the Environmental Kuznets Curve does not hold for all gases, it is rather an empirical artefact than a regularity.

The Environmental Kuznets Curve. An empirical analysis for OECD countries

International Nuclear Information System (INIS)

Georgiev, E.

2008-09-01

This paper tests the Environmental Kuznets Curve hypothesis for four local (SOx, NOx, CO, VOC) and two global (CO2, GHG) air pollutants. Using a new panel data set of thirty OECD countries, the paper finds that the postulated inverted U-shaped relationship between income and pollution does not hold for all gases. A meaningful Environmental Kuznets Curve exists only for CO, VOC and NOx, where for CO2 the curve is monotonically increasing. For GHG there is indication of an inverted U-shaped relationship between income and pollution, but still most countries are on the increasing path of the curve and hence the future development of the curve is uncertain. For SOx it was found that emissions follow an U-shaped curve. Based on the empirical results, the paper concludes that the Environmental Kuznets Curve does not hold for all gases, it is rather an empirical artefact than a regularity.

Depression in dementia: development and testing of a nursing guideline.

NARCIS (Netherlands)

Verkaik, R.

2009-01-01

Guideline for pleasure in dementia care Depression in nursing home residents with dementia can be decreased by the introduction of a nursing guideline. This is the main conclusion of the PhD thesis on depression in dementia that was presented by researcher Renate Verkaik on April 20th at the

Productivity changes in OECD healthcare systems: bias-corrected Malmquist productivity approach.

Science.gov (United States)

Kim, Younhee; Oh, Dong-Hyun; Kang, Minah

2016-10-01

This study evaluates productivity changes in the healthcare systems of 30 Organization for Economic Co-operation and Development (OECD) countries over the 2002-2012 periods. The bootstrapped Malmquist approach is used to estimate bias-corrected indices of healthcare performance in productivity, efficiency and technology by modifying the original distance functions. Two inputs (health expenditure and school life expectancy) and two outputs (life expectancy at birth and infant mortality rate) are used to calculate productivity growth. There are no perceptible trends in productivity changes over the 2002-2012 periods, but positive productivity improvement has been noticed for most OECD countries. The result also informs considerable variations in annual productivity scores across the countries. Average annual productivity growth is evenly yielded by efficiency and technical changes, but both changes run somewhat differently across the years. The results of this study assert that policy reforms in OECD countries have improved productivity growth in healthcare systems over the past decade. Countries that lag behind in productivity growth should benchmark peer countries' practices to increase performance by prioritizing an achievable trajectory based on socioeconomic conditions. For example, relatively inefficient countries in this study indicate higher income inequality, corresponding to inequality and health outcomes studies. Although income inequality and globalization are not direct measures to estimate healthcare productivity in this study, these issues could be latent factors to explain cross-country healthcare productivity for future research. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Introduction of regulatory and licensing procedures of some OECD countries in the field of decommissioning

International Nuclear Information System (INIS)

Benedekfi, O.; Zagyvai, P.; Czifrus, S.; Ormai, P.; Danko, G.

2001-01-01

In the OECD countries more than 50 nuclear power plants will have to be closed in the beginning of the next century since their licenses expire. For this reason it is very important to establish reasonable regulations in the field of decommissioning. In this poster firstly we define the basic principles related to decommissioning. Then we account on our survey of the situation of the regulatory and licensing procedures in some OECD countries. Finally we compare the results. (authors)

Does Corporate Income Taxation Affect Securitization? Evidence from OECD Banks

NARCIS (Netherlands)

Gong, D.; Ligthart, J.E.

2013-01-01

Abstract: Corporate income taxation, by affecting the after-tax cost of funding, has implications for a bank's incentive to securitize. Using a sample of OECD banks over the period 1999-2006, we fi nd that corporate income taxation led to more securitization at banks that are constrained in funding

Housing market volatility in the OECD area

DEFF Research Database (Denmark)

Engsted, Tom; Pedersen, Thomas Quistgaard

2014-01-01

Vector-autoregressive models are used to decompose housing returns in 18 OECD countries into cash flow (rent) news and discount rate (return) news over the period 1970-2011. For the jajority of countries news about future returns is the main driver, and both real interest rates and risk-premia play...... an important role in accounting for housing market volatility. Bivariate cross-country correlations and principal components analyses indicate that part of the return movements have a common factor among the majority of countries. We explain the results in terms of global changes in credit constraints...

IMPACTS OF AFRICA'S TOTAL AND COMMODITY-BASED TRADE WITH CHINA AND OECD COUNTRIES

Directory of Open Access Journals (Sweden)

Nihal Bayraktar

2017-02-01

Full Text Available This paper studies the changes in the pattern of Africa’s trade with China and OECD countries, and the impacts of these changes on sub-Saharan Africa’s economic growth. In the study, the country-level total exports and imports, as well as the commodity-based exports and imports are considered for 42 sub-Saharan African countries between 1980 and 2014. The results show that as the share of China in sub-Saharan Africa’s trade has significantly increased, a declining trend is observed for OECD countries, traditional trading partners. Despite changing trade links, the investigation of the commodity-based exports and imports indicate that the types of imported and exported commodities have not changed much for Africa. However, a strong link is observed between economic growth in SSA and its changing trade links from the OECD countries towards China at the total level as well as at the commodity level. The study concludes that there is an increase in the international competition for Africa’s commodities, and resulting in improvements in the terms of trade has led to higher income growth in the region.

Proposed quality control guidelines for National Committee for Clinical Laboratory Standards Susceptibility Tests using the veterinary antimicrobial agent tiamulin.

Science.gov (United States)

Pfaller, M A; Jones, R N; Walter, D H

2001-01-01

Quality control guidelines for standardized antimicrobial susceptibility test methods are critical for the continuing accuracy of these clinical tests. In this report, quality control limits were proposed for the veterinary antimicrobial agent tiamulin with minimum inhibitory concentration (MIC) ranges of three or four log(2) dilution steps in two different medium formulations. Disk diffusion zone diameter ranges were proposed for tiamulin tested against Actinobacillus pleuropneumoniae ATCC 27090 (12-18 mm) and Staphylococcus aureus ATCC 25923 (25-32 mm). The data from eight participating laboratories produced 100% of results within proposed MIC limits (8-32 microg/mL), and 95.8-97.0% of zones were found within suggested zone diameter QC guidelines. These proposed QC ranges should be validated by in-use results from veterinary clinical laboratories.

78 FR 71676 - NUREG-1482, Revision 2, “Guidelines for Inservice Testing at Nuclear Power Plants, Final Report”

Science.gov (United States)

2013-11-29

... Testing at Nuclear Power Plants, Final Report'' AGENCY: Nuclear Regulatory Commission. ACTION: Notice of... entitled: NUREG-1482, Revision 2, ``Guidelines for Inservice Testing at Nuclear Power Plants,'' and... Restraints (Snubbers) at Nuclear Power Plants.'' In the previous Revisions 0 and 1 of NUREG-1482, the NRC...

Investigation of widely used nanomaterials (TiO{sub 2}, Ag) and gold nanoparticles in standardized ecotoxicological tests

Energy Technology Data Exchange (ETDEWEB)

Hund-Rinke, Kerstin; Klawonn, Thorsten [Fraunhofer-Institut fuer Molekularbiologie und Angewandte Oekologie (IME), Schmallenberg (Germany)

2013-04-15

nanomaterial gold. Since ecotoxicological data based on standardised test methods, as requested for risk assessment, are not available for these substances, and information on modifications to standardised procedures for testing nanoparticles is lacking, the aim of the present project was to contribute to the following topics: - Recommendations concerning the improvement of existing OECD Test Guidelines for the testing of nanoparticles; - Recommendations on the application of the investigated nanoparticles to the test medium; - Ecotoxicity of TiO{sub 2} and Ag nanoparticles with respect to: Earthworm reproduction, Respiration rate of soil microflora, Nitrification of soil microflora, Growth of plants, Reproduction of chironomids, Reproduction of daphnids. - Ecotoxicity of gold with respect to: Growth of algae, Immobilisation of daphnids, Development of fish embryos, Reproduction of chironomids. As a first step in the present project the German Federal Environment Agency selected several nanoparticles from the priority list of the OECD Sponsorship Programme, and the tests that should be performed with these nanoparticles were selected on the basis of available informa-tion and priority.

Rasplav. A unique OECD/Russian experimental/analytical program in severe accident management/mitigation

International Nuclear Information System (INIS)

Speis, T.P.; Behbahani, A.

1995-01-01

In 1994 the Nuclear Energy Agency of the Organization for Economic Cooperation and Development (NEA-OECD) sponsored the RASPLAV project in Russia to carry out an integrated program of experiments and analyses to address the conditions under which a degraded/molten core can be retained inside the reactor pressure vessel via cooling of the vessel from outside. The background, the objectives, the technical issues associated with, the utilization of the results and the benefits to the participating countries are discussed, involving Russian partnership with the most advanced OECD member countries in a project which will be carried out at the Kurchatov Institute in Russia. (author). 1 fig

Impact of Modified 2013 ASCO/CAP Guidelines on HER2 Testing in Breast Cancer. One Year Experience.

Directory of Open Access Journals (Sweden)

Zsuzsanna Varga

Full Text Available The latest guidelines of the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP to test Human Epidermal Growth Factor Receptor 2 (HER2 in breast cancer after being revised in 2008 underwent a second modification in October 2013. The modification includes changes in cut-offs: 10% strong membranous staining for score 3+ on immunohistochemistry (IHC (previously 30% and using the ratio of >2 or absolute gene-copy-number (6 or more alone or in combination with each other by in-situ-hybridisation technology (previously >2.2 and average copy-number of 6 or more. Hereby we addressed the question, which impact the modified cut-offs had on overall HER2-positivity in a single institution.We prospectively analysed 617 consecutive diagnostic breast-cancer cases which underwent double HER2 testing by immunohistochemistry and fluorescent in-situ hybridisation (FISH, using the modified 2013 ASCO/CAP-guidelines for one year (October 2013-October 2014. Results were compared with HER2-test results on 1,528 consecutive diagnostic breast-cancer cases from two previous years (2011-2012, using the 2008 ASCO/CAP guidelines, also tested with IHC and FISH in each case.Between October 2013 and October 2014, overall HER2-positivity was 15.8% (98 of 617 cases were either IHC 3+ or FISH amplified. 79 of 617 cases (13% were IHC 3+, 96 of 617 cases (15.5% were FISH amplified. Equivocal cases were seen in 25 of 617 cases (4.1%. 22 of 25 equivocal cases (88% in 2013-2014 were IHC 1+ or 2+. In 13 equivocal cases, there was a repeated IHC/FISH testing: 2 of 13 cases (15% became FISH amplified, 1 of 13 cases (7.5% became IHC 3+. In 2011-2012, overall HER2-positivity (IHC/FISH was 13.8% (211 of 1,528 cases. 185 of 1,528 cases (12% were 3+ on IHC, 181 of 1,522 cases (12% were amplified by FISH. Six of 1,528 cases were equivocal by FISH, and interpreted as non-amplified (0.3%.Applying the modified ASCO/CAP guidelines from 2013 resulted in an increase (2

The Role of the OECD and the EU in the Development of Labour Market Policy in the Czech Republic

DEFF Research Database (Denmark)

Porte, Caroline de la

2009-01-01

This article analyses the role of the OECD through its "Jobs Strategy" and the European Union (EU) through the "European Employment Strategy" in the development of macro-economic, employment and labour market policy in the Czech Republic. As a full member of the two organisations, the Czech...... Republic has been subject to their soft non-binding policy advice in the area of labour market reform. The OECD and EU policy models are similar, both insisting on growth-oriented macro-economic policy, supported by active labour market policies, an active and effective public employment service (PES......) and the de-regulation of labour markets. However, the OECD actively advocates private actor involvement in labour markets, while the EU insists on the role of the public sector. The inquisitive styles of the two organisations differ: the OECD has a decontextualised and quantified analysis of performance...

Training Guidelines in Non-Destructive Testing Techniques: Leak Testing at Level 2

International Nuclear Information System (INIS)

2012-01-01

The International Atomic Energy Agency (IAEA) has been active in the promotion of non-destructive testing (NDT) technology for many decades. The prime reason for this interest has been the need for stringent standards for quality assurance for safe operation of nuclear and other industrial installations. The IAEA successfully executed a number of programmes, including technical cooperation projects (national and regional) and coordinated research projects (CRPs), in which NDT was an important part. Through these programmes, a large number of personnel have been trained in Member States, leading to the establishment of national certifying bodies responsible for the training and certification of NDT personnel. Consequently, a state of self-sufficiency in this area of technology has been achieved in many Member States. All along there has been a realization of the need to have well established training guidelines, in order to orient the IAEA experts who were involved in training and certification programmes, and to achieve some level of international uniformity and harmonization of training materials and certification processes, and consequent competence of NDT personnel.

Does corporate income taxation affect securitization? : Evidence from OECD banks

NARCIS (Netherlands)

Gong, Di; Hu, Shiwei; Ligthart, J.E.

2015-01-01

Corporate income taxation, by affecting the after-tax cost of funding, has implications for a bank’s incentive to securitize. Using a sample of OECD banks over the period 1999–2006, we find that corporate income taxation led to more securitization at banks that are constrained in funding markets,

Potential effects of emission taxes on CO2 emissions in the OECD and LDCs

International Nuclear Information System (INIS)

Messner, S.; Strubegger, M.

1991-01-01

A set of existing optimization models, which represent the energy systems of the OECD and LDCs (less developed countries excluding centrally planned economies) with a time horizon to 2020, has been applied to derive first-order estimates of the techno-economic potential for emission reduction. The driving force for the introduction of reduction measures is a scheme of taxes levied on the emission of six pollutants, including the greenhouse gases CO 2 and methane. The tax levels introduced are based on taxes discussed by the Swedish government: they are the break-even point to test which measures are cost-effective and which emission levels can be reached at these costs. The regional models include the following alternatives: (i) reduction of final energy demand by supplying the requested services by other means (i.e., conservation); (ii) substitution of new fuels for polluting fuels; (iii) introduction of clean technologies for the same purposes; (iv) additions of pollution-reduction technologies. Alternative scenarios with emission taxes are compared with a base scenario without taxes related to pollutant emissions. The results indicate that an increase in CO 2 emissions in the OECD and LDC regions of 47% over the next 30 yr in the base scenario would be changed to stable levels to 2010 by tax-induced measures. Thereafter, energy-consumption growth in the LDCs reverses this trend. (author)

OECD Ülkelerinde Eğlence Vergisi Uygulamaları(Amusement Tax Applications in the OECD Countries

Directory of Open Access Journals (Sweden)

Bernur AÇIKGÖZ ERSOY

2010-01-01

Full Text Available In the 17th century, “the right of the poor” was a transitory tax on the income of entertainment in favor of public assistance in France. “The right of the poor” was abolished later by the regime of Vichy, which created a permanent tax on games and entertainment to the direct benefit of the communes. Later, other European countries followed the example of France by introducing a so-called amusement tax. The paper is organized as follows: The first part presents the historical development and theoretical base of amusement tax and amusement tax applications in the OECD countries. The second part shows the amusement tax application in Turkey, and the last part resumes arguments in favor of the maintenance or an abolishment of the tax on entertainment.

OECD/NEA study on the economics of the long-term operation of nuclear power plants

Energy Technology Data Exchange (ETDEWEB)

Lokhov, A.; Cameron, R. [OECD Nuclear Energy Agency, 12, boulevard des Iles, 92130 Issy-les-Moulineaux (France)

2012-07-01

The OECD Nuclear Energy Agency (NEA) established the Ad hoc expert group on the Economics of Long-term Operation (LTO) of Nuclear Power Plants. The primary aim of this group is to collect and analyse technical and economic data on the upgrade and lifetime extension experience in OECD countries, and to assess the likely applications for future extensions. This paper describes the key elements of the methodology of economic assessment of LTO and initial findings for selected NEA member countries. (authors)

Intergovernmental organisation activities: European Atomic Energy Community, International Atomic Energy Agency, OECD Nuclear Energy Agency

International Nuclear Information System (INIS)

Anon.

2012-01-01

European Atomic Energy Community: Proposed legislative instruments, Adopted legislative instruments, Non-legislative instruments, Other activities (meetings). International Atomic Energy Agency: IAEA Action Plan on Nuclear Safety. OECD Nuclear Energy Agency: The Russian Federation to join the OECD Nuclear Energy Agency; Participation by the regulatory authorities of India and the United Arab Emirates in the Multinational Design Evaluation Programme (MDEP); NEA International Workshop on Crisis Communication, 9-10 May 2012; International School of Nuclear Law: 2013; Next NEA International Nuclear Law Essentials Course

Tax Havens and the OECD Campaign Against them

OpenAIRE

Narci, Hakan

2012-01-01

There are two essential primary purposes for this thesis. The first has been to highlight the phenomena Tax Havens with its economical impact on other countries outlined in chapter two. Firstly the concept of tax havens is presented based on the OECD definition. Secondly the secrecy legislation, regulation and the corporate structures which tax havens offer to foreign investors and firms are given with their significance for other states. Thirdly, the ways tax havens are used b...

Elaboration of a guideline for counterpart testing of integral loop systems

International Nuclear Information System (INIS)

Karwat, H.

1988-01-01

A previous study on the problems of scaling and extrapolation of experimental results indicated the necessity to overcome some uncertainty in the achievable code accuracy when applied to full size reactor systems. The empirical approach in simulating interfacial relationships within systems behaviour codes in combination with the liberty of nodalisation requires a careful assessment of the overall validity of the code verification concept. Several new test facilities are presently under construction to study fluid-dynamic effects of interest for the behaviour of PWRs under small break LOCA conditions in a larger dimension and with somewhat modified scaling considerations. The test results expected from these new facilities may be useful to assess the overall validity of the analytical simulation concept of the applied computer codes. Test facilities of interest within the European Community are the - LOBI Test Facility (vol. scaling 1/700) at JRC-Ispra - SPES Test Facility (vol. scaling 1/425) in Italy - BETHSY Facility (vol scaling 1/100) in France and outside Europe the - ROSA IV Facility (vol. scaling 1/50) in Japan. Main objective of the study was the elaboration of a guideline for the particular requirements of meaningful counterpart testing with the final aim to qualify the overall validity of code simulation concepts and the expected predictive accuracy of code applications for full size prototype PWRs

Training Guidelines in Non-destructive Testing Techniques. 2013 Edition

International Nuclear Information System (INIS)

2014-12-01

The IAEA promotes industrial applications of radiation technology, including non-destructive testing (NDT), through activities such as Technical Cooperation Projects (national and regional) and Coordinated Research Projects. Through this cooperation, Member States have initiated national programmes for the training and certification of NDT personnel. National certifying bodies have also been established based on International Organization for Standardization (ISO) standards. As part of these efforts, the IAEA has been actively involved in developing training materials. Consequently, IAEA-TECDOC-407, Training Guidelines in Non-destructive Testing Techniques, was published in 1987, then revised and expanded as IAEA-TECDOC-628 in 1991. Revisions of IAEA-TECDOC-628 were considered essential to meet the demands of end-user industries in Member States, and revised and expanded versions were issued in 2002 and 2008. These latter versions included work conducted by the International Committee for Non-Destructive Testing (ICNDT) and many national NDT societies. It is one of the publications referred to in ISO 9712:2005, Non-destructive Testing: Qualification and Certification of Personnel, which in turn is an internationally accepted standard, revised as ISO 9712:2012, Non-destructive Testing: Qualification and Certification of NDT Personnel. This publication is an updated version of IAEA-TECDOC-628. The content of which has been revised following the changes of ISO 9712 converging with EN 473 and becoming EN ISO 9712:2012, based on the experience of experts and comments from end-user industries. The details of the topics on each subject have been expanded to include the latest developments in the respective methods. The incorporated changes will assist the end-user industries to update their NDT qualification and certification schemes and course materials. This publication, like the previous versions, will continue to play an important role in international harmonization

Overview of OECD/NEA BEPU Programmes

International Nuclear Information System (INIS)

Amri, Abdallah; Gulliford, Jim; )

2013-01-01

The OECD/NEA paved the way for the development and assessment of BEPU for about 40 years, through concrete tasks: International Standard Problems (ISPs), Benchmarking activities, Development of Validation Matrices, Joint Safety Research Projects, and Specialist meetings. Several NEA related Best-Estimate Plus Uncertainties (BEPU) programmes have been successfully completed: Uncertainty Methods Study (UMS), Best-Estimate Methods - Uncertainty and Sensitivity Evaluation (BEMUSE), Safety Margin Assessment and Application (SM2A), Uncertainty Analysis in Modeling (UAM) Benchmark. New Programmes are underway to address pending issues (e.g., input uncertainties, uncertainties in coupled codes). The present Workshop may highlight new issues to be addressed (e.g., uncertainty analysis for CFD codes). Document available in the slides-form only

Thyroid Histopathology Assessments for the Amphibian Metamorphosis Assay to Detect Thyroid-active Substances

Science.gov (United States)

In support of an Organization for Economic Cooperation and Development (OECD) Amphibian Metamorphosis Assay (AMA) Test Guideline for the detection of substances that interact with the hypothalamic-pituitary-thyroid axis, a document was developed that provides a standardized appro...

Case report: BRCA in the Ashkenazi population: are current testing guidelines too exclusive?

Directory of Open Access Journals (Sweden)

Saunders Katherine H

2011-06-01

Full Text Available Abstract The BRCA1/2 genes account for a significant portion of hereditary breast and ovarian cancers and they are especially prevalent in the Ashkenazi Jewish population. Women who have a mutation can prevent breast and ovarian cancer with surgical intervention. We describe an Ashkenazi Jewish patient who illustrates that current testing criteria are too restrictive, particularly for this population of patients. The patient's sister was diagnosed with breast cancer at age 33; however, she was not a mutation carrier. Based on practice guidelines, the patient was not recommended genetic testing. She subsequently underwent direct-to-consumer (DTC testing and discovered that she was a mutation carrier. This case demonstrates the need for clinicians to be aware of the higher prevalence of BRCA mutations in the Ashkenazi population. It also exemplifies the need to involve medical professionals, including genetic counselors, in the dissemination of DNA test results.

General dependencies and causality analysis of road traffic fatalities in OECD countries.

Science.gov (United States)

Yaseen, Muhammad Rizwan; Ali, Qamar; Khan, Muhammad Tariq Iqbal

2018-05-07

The road traffic accidents were responsible for material and human loss which was equal to 2.8 to 5% of gross national product (GNP). However, literature does not explore the elasticity coefficients and nexus of road traffic fatalities with foreign direct investment, health expenditures, trade openness, mobile subscriptions, the number of researchers in R&D department, and environmental particulate matter. This study filled this research gap by exploring the nexus between road traffic fatalities, foreign direct investment, health expenditures, trade openness, mobile subscriptions, the number of researchers, and environmental particulate matter in Organization for Economic Cooperation and Development (OECD) countries by using panel data from 1995 to 2015. The panel Autoregressive Distributed Lag (ARDL) bound test was used for the detection of cointegration between the variables after checking the stationarity in selected variables with different panel unit root tests. Panel vector error correction model explored the causality of road traffic fatalities, foreign direct investment, PM2.5 in the environment, and trade openness in the long run. Road traffic fatalities showed short run bi-directional causality with foreign direct investment and health expenditures. The short run bi-directional causality was also observed between trade and foreign direct investment and cellular mobile subscriptions and foreign direct investment. The panel fully modified ordinary least square (FMOLS) and panel dynamic ordinary least square (DOLS) showed the 0.947% reduction in road fatalities for 1% increase in the health expenditures in OECD countries. The significant reduction in road fatalities was also observed due to 1% increase in trade openness and researchers in R&D, which implies the importance of trade and research for road safety. It is required to invest in the health sector for the safety of precious human lives like the hospitals with latest medical equipment and improvement

The Implementation of hydrogen mitigation techniques: summary and conclusions: OECD Workshop

International Nuclear Information System (INIS)

1996-01-01

The OECD Workshop on the Implementation of Hydrogen Mitigation Techniques was held in Winnipeg, Canada from 1996 May 13 to 15. Sixty-five experts from twelve OECD Member countries and the Russian Federation attended the meeting. Thirty-five papers were presented in six sessions: accident management and analyses, relevant aspects of hydrogen production, distribution and mixing, engineering, technology, possible side-effects and consequences, new designs. The objectives of the Workshop were to establish the state-of-the-art of hydrogen mitigation techniques, with emphasis on igniters and catalytic recombiners, to exchange information on Member countries' strategies in managing hydrogen mitigation and to establish dialogue as to differences in approach, to determine whether there is now an adequate technical basis for such strategies or whether more work - in which areas - is desirable, and to exchange information on future plans for implementation of hydrogen mitigation techniques

Future direction for implementing the cooperation with OECD/NEA

International Nuclear Information System (INIS)

Kim, Kyoung Pyo; Hong, Yong Don

1999-03-01

The Nuclear Energy Agency (NEA) within the Organization for Economic Cooperation and Development (OECD) ia an intergovernmental organization consisting of industrialized countries with shared democratic principles and free market economics. The objectives of the agency are to identify key issues related to nuclear energy and to address these issues as well as to implement joint R and D projects, contributing to the development of nuclear energy as a safe, environmentally-acceptable and economical energy source through cooperation among its participating countries. Appropriate measures to effectively implement international nuclear cooperation and strategies to upgrade Korea's status in the international arena as well as ways to utilize the agency for our benefits through analysis of its policy and current status of the agency as a multilateral nuclear cooperative body are also presented in this report. Analysis of information about the agency's activities and acquisition of capabilities to collect relevant information, coupled with efforts to enhance Korea's status in the international nuclear arena by actively being involved in the international organizations such as OECD/NEA are required to positively deal with rapid changes in the international nuclear arena and establish effective national nuclear policies. This report can be utilized as valuable material not only in establishing national nuclear policy by giving an overview of the report prepared by the high level advisory group on the future of the OECD Nuclear Energy Agency, who recently wrapped up their activities, but also in promoting the understanding of the agency's activities and the agency's long-term perspective mapped out in 1995. Future plans and strategies for effective implementation of nuclear cooperation with the agency, including ways to participate in the agency's activities, with KAERI taking a leading role, and in the NEA joint R and D projects, ways to strengthen capabilities, to analyze

Taxation of International Performing Artistes: the problems with Article 17 OECD and how to correct them

OpenAIRE

Molenaar, Dick

2006-01-01

textabstractThis thesis is about the taxation of international performing artistes. Their performance income is often generated in many countries other than their country of residence, and this performance income is subject to special tax treatment. Most countries have followed the OECD recommendation to tax the performance income of non-resident artistes. Article 17 of the OECD Model Tax Convention sets aside the normal allocation rules of Article 7 (Business Profits) and Article 15 (Income ...

The Impact of the OECD BEPS Action Plan on Finnish Multinational Companies – Case Study

OpenAIRE

Hirvinen, Jyri

2017-01-01

This research attempts to evaluate the effects that the new OECD BEPS action plan might cause to the companies, main focus being in Finnish multinational companies and in the company being researched in the case study part of the research. The author understands the limitations of the one company case study model in the research but believes that use-ful information can be gained on the effects of the OECD BEPS action plan by examining the changes that the case study company has to go through...

Spanish collaboration in the OECD Halden Reactor Project research on Gadolinia Fuel

International Nuclear Information System (INIS)

Horvath, M. I.; Jenssen, H. K.; Munoz-Reja, C.; Tverberg, T.

2011-01-01

Safe and reliable operation of nuclear power plants benefit from research and development advances and related technical solutions. One research platform is the OECD Halden Reactor Project (HRP), HRP is a joint undertaking of national organisations in 18 countries sponsoring a jointly financed programme under the auspices of the OECD-Nuclear Energy Agency (NEA). As a member state, Spain is participating HRP research programs with ENUSA as partner in the fuel research programs. Various experiments are developed and performed also by providing materials, ENUSA collaborates with HRP on various experiments investigating the fuel behaviour, especially on Gd-bearing fuel. 20 years of successful collaboration between HRP and ENUSA is continuing with promising and results to ensure and enhance the safe operation of the Spanish and all other NPPs in the world. (Author) 12 refs.

Actinide separation chemistry in nuclear waste streams, an OECD Nuclear Energy Agency review

International Nuclear Information System (INIS)

Madic, C.

1997-01-01

The separation of actinide elements from various waste materials, either produced in nuclear fuel cycle or in the past during nuclear weapon production, represent a significant issue facing developed countries. Improvements in the efficiencies of the separation processes can be expected from a better knowledge of the chemistry of these elements in these complex matrices. The Nuclear Science Committee of the OECD/NEA has established a task force of experts in actinide chemistry to review the current and developing separation techniques and chemical processes. Recommendations were made for future research and development programs. This article presents briefly the work of the Task Force which will be published soon as an OECD/NEA/NSC Report. (author)

OECD, EEC and French Economic and Social Council documents on the energy policy

International Nuclear Information System (INIS)

Documents on the energy policy until 1985, prepared by the OECD, the EEC and the French Economic and Social Council, are presented. They include: the main conclusions and a summary of the 1974 report by the General Secretary of the OECD on the energy prospects up to 1985; the communication presented by the Commission to the EEC Council on June 5th 1974 concerning the new strategy of energy management for the Community (the resolution on the aims for 1985 and the means necessary for their attainment were proposed and accepted on December 17th 1974); the medium- and long-term energy problems in France presented by the French Economic and Social Council in July 1974 [fr

Factors affecting the future of nuclear power in OECD Europe

International Nuclear Information System (INIS)

Thompson, S.

1997-01-01

This report provides a brief review of nuclear power in OECD Europe and addresses the prospects for its future over, say, the next quarter century. Most of the data and findings are drawn from studies published by the Nuclear Energy Agency (NEA) of the Organisation for Economic Co-operation and Development (OECD). The NEA is a small agency with a rather modest budget whose 27 members are industrialized countries from North America, Asia and Europe. The Agency works to pool the expertise of our member countries to produce technical, economic and legal work of considerable depth and quality addressing issues of common interest to those countries. Our work covers such fields as nuclear science, nuclear power economics, nuclear safety, radiation protection, waste management and nuclear liability. The studies carried out in the framework of the Agency require fewer resources than would be needed by our member countries if they were to pursue them individually, which is especially important at a time of cut-backs in national programmes in such critical areas as nuclear safety research. (author)

Energy statistics of OECD countries 1993-1994

International Nuclear Information System (INIS)

1996-01-01

This work contains a compilation of energy supply and consumption data in original units for coal, oil, gas, electricity, heat, renewable combustible and waste. Historical tables summarize data on production, trade and final consumption of hard coal, brown coal, oil, natural gas and electricity. Each issue includes definitions of products and flows and explanatory notes on the individual country data. The data contained in this publication are presented in comprehensive energy balances expressed in million tonnes of oil equivalent in Energy Balances of OECD Countries, 1993-1994, the sister volume of this publication. (authors). figs., tabs

Trade-related Electronic Commerce Issues in the OECD

OpenAIRE

Chang-In Yoon

1998-01-01

The trade committee of Organization for Economic Cooperation and Development (OECD) has begun the study of the trade related to electronic commerce since 1997. The scale of the study on one hand has avoided the fact of copy and duplication of WTO and its organizational principles, on the other hand it has played a supplementary and supportive function. At present, digital-related product, such as computers, software and travel is the key point to the trade which resorts to electronic commerce...

Address to the OECD Council. 30 September 1998

International Nuclear Information System (INIS)

ElBaradei, M.

1998-01-01

The document reproduces the text of the statement made by the Director General of the IAEA at the OECD Council, on 30 September 1998. The conference gave an overview on the role and work of the IAEA in relation to the following main topics: the role of nuclear power in the twenty-first century, the management of nuclear power in this century, the challenge of verification, safeguards and the security of nuclear material, and the particular importance and contribution of nuclear technology transfer

National Approaches to Adaptation. Some Lessons Learnt from recent OECD and UNFCCC Workshops

International Nuclear Information System (INIS)

Willems, S.

2005-01-01

Adaptation to climate change is a challenge that all countries are currently facing. Most countries have already started to develop national or sectoral adaptation strategies. In parallel, an international process has also started to emerge to support these national adaptation efforts, whereby countries share their experiences with - and exchange views on - their national strategies. At the end of last year, two international meetings took place around adaptation issues, which brought together Annex I and non-Annex I Parties: the OECD Global Forum on Sustainable Development: Development and Climate Change, on 11-12 November 2004; and the In-Session Workshop on adaptation, as part of the SBSTA meetings, on 8 December 2004. Another international workshop on adaptation practices and strategies took place in Wellington, New Zealand, on 11-13 October, which was limited to OECD countries. This paper provides a brief summary of the national approaches presented at the OECD and UNFCCC workshops, as well as some preliminary insights on national adaptation strategies that emerge from these events. The intent is to facilitate further exchanges of views on adaptation, such as the one that took place within the Seminar of the Annex I Expert Group 'Working Together to Respond to Climate Change', on 21-22 March 2005

Energy consumption and economic growth for selected OECD countries: Further evidence from the Granger causality test in the frequency domain

International Nuclear Information System (INIS)

Bozoklu, Seref; Yilanci, Veli

2013-01-01

This paper aims to reexamine the causal relationship between energy consumption and economic growth for 20 OECD countries. To that end, we employ a Granger causality test in the frequency domain which allows us to distinguish short (temporary) and long-run (permanent) causality. The empirical results could be summarized as following. First, in terms of causality running from GDP to energy consumption, there is a temporary relationship for Australia, Austria, Canada, Italy, Japan, Mexico, the Netherlands, Portugal, the UK, the USA, and a permanent relationship for Austria, Belgium, Denmark, Germany, Italy, Japan, the Netherlands, Norway, and the USA. Second, in terms of causality running from energy consumption to GDP, there is a temporary relationship for Austria, Denmark, Italy, the Netherlands, Norway and Portugal, and a permanent relationship for Belgium, Finland, Greece, Italy, Japan, and Portugal. The main implication of our finding is that the energy policies should take into consideration not only the causality direction between economic growth and energy consumption but also whether it is temporal or permanent and furthermore authorities must design policy actions accordingly. - Highlights: • This study reexamines the causal relationship between energy consumption and economic growth. • We employ frequency causality analysis to determine temporary and permanent causality. • The results provide evidence of both temporary and permanent causality relationships for countries examined. • Energy policies should consider whether the causality is temporal or permanent

Factors prompting PSA-testing of asymptomatic men in a country with no guidelines: a national survey of general practitioners.

LENUS (Irish Health Repository)

Drummond, Frances J

2009-01-01

BACKGROUND: Increased use of prostate specific antigen (PSA) has been associated with increased prostate cancer incidence. Ireland is estimated to have one of the highest prostate cancer incidences in Europe and has no national guidelines for prostate cancer screening. GPs have a pivotal role in influencing PSA testing, therefore, our aim was to describe GP testing practices and to identify factors influencing these. METHODS: A postal survey, including questions on clinical practice and experience, knowledge and demographics was distributed to all GPs (n = 3,683). The main outcomes were (i) PSA testing asymptomatic men and (ii) "inappropriate" PSA testing, defined as testing asymptomatic men aged < 50 or > 75 years. Factors associated with these outcomes were identified using logistic regression. RESULTS: 1,625 GPs responded (response rate corrected for eligibility = 53%). Most respondents (79%) would PSA test asymptomatic men. Of these, 34% and 51% would test asymptomatic men < 50 and > 75 years, respectively. In multivariate analyses, GPs were more likely to test asymptomatic men if they were >or= 50 years, in practice >or= 10 years, female or less knowledgeable about PSA efficacy. Male GPs who would have a PSA test themselves were > 8-times more likely to PSA test asymptomatic men than GPs who would not have a test. GPs who had an asymptomatic patient diagnosed with prostate cancer following PSA testing, were > 3-times more likely to test asymptomatic men. Practice-related factors positively associated with testing included: running \\'well man\\' clinics, performing occupational health checks and performing other tests routinely with PSA. Factors positively associated with \\'inappropriate\\' testing included; being male and willing to have a PSA test, having worked\\/trained in the UK and supporting annual PSA testing. 91% of respondents supported the development of national PSA testing guidelines. CONCLUSION: Our findings suggest that widespread PSA testing

Description of Website for the OECD-IAEA Paks Fuel Project

International Nuclear Information System (INIS)

Szabo, Emese; Hozer, Zoltan; Nagy, Imre

2010-01-01

The first version of the database for the OECD-IAEA PAKS FUEL PROJECT has been collected and it is available on the following password protected website: http://nagy.aeki.kfki.hu Several modifications have been made and new items added according to the minutes of the 1st meeting held in Budapest on 30-31 January 2005

Genomic testing in international guidelines

Directory of Open Access Journals (Sweden)

Peter Kern

2013-10-01

Full Text Available Human breast cancer was solely classified based on clinical and immunohistochemical (IHC findings in the past. A growing body of evidence suggests that these categorisations are rendered more precisely by intrinsic subtyping with the aim of an introduction of personalised medicine. Especially in breast cancer with the uncertain potential of disease spread, such as T1-2, Grade 2 and oestrogen receptor-positive (ER+ve tumours, the value of chemotherapy applied to every patient has been questioned and the need for additional information on the tumour´s specific risk of recurrence is overt. It is estimated that the average risk for recurrence is 15% at 10 years in hormone-receptor-positive breast cancer. Thus, a relatively small proportion of these patients would need chemotherapy, and the main task is to stratify which patients of this cohort are at high-risk and will benefit from cytotoxic agents. Ki67, as a proliferation marker classifying high-risk tumours, has been demonstrated as a continuous marker, but not as a clear cut risk-defining instrument in recent publications. Thus, the difficulties are perceived especially at the threshold of the low to high-risk area of this marker. Reproducibility of Ki67 is to some extent uncertain considering there is inter and intra-institutional variability of up to 30% of the results. Several multi gene arrays, such as MammaPrint®, Oncotype DX®, Endopredict®, and PAM50 have demonstrated clinical utility and experienced validation. The aim of this review is the description of the implementation of genomic testing in international guidelines (North American and European, with regard to incorporation of multigene arrays into the decision-making process in different clinical settings (including tumor size and IHC status. Data cut-off was 1st October, 2013. It seems that North America and some European countries have initiated a shift towards a personalised medicine with multigene arrays based on RT-PCR or

The imperfect price reversibility of non-transport oil demand in the OECD

International Nuclear Information System (INIS)

Dargay, J.; Gately, D.

1995-01-01

This paper examines the price reversibility of OECD non-transport oil demand and its components: residual (heavy) fuel oil, non-transport distillates and other non-transport oil products. Our purpose is to determine the extent to which the reductions in demand following the oil price increases of the 1970s have been - and will be - reversed by the price cuts of the 1980s. The analysis is based on an econometric model which utilizes price decomposition methods to measure separately the effects of price increases and price decreases. These methods allow empirical testing of irreversibility and hysteresis, and should be applicable in other areas of economics where asymmetry of response or persistence of effect are evident. Based on the statistical evidence, we reject the conventional specification of demand being perfectly price reversible. We conclude that the response to the price cuts of the 1980s has been significantly smaller than to the price increases of the 1970s. Demand has followed a ratchet process: price increases reduced demand substantially when demanders conserved and switched away from oil, but price cuts did not reverse this process completely, if at all. This has important implications for projections of oil demand, especially under low price assumptions: the OECD's dependency on oil will not increase as much as some analysts may have feared. There is, however, another aspect of imperfect price reversibility: the possibilities of adjusting to future price rises may not be as great as they have been in the past. The easiest and least costly demand savings have already been made, and oil has been replaced by other energy sources in many uses: what's done is done. (author)

Proceedings of the Third Meeting of the OECD-NEA Expert Group on Accident Tolerant Fuels for LWRs, 3-5 March 2015, OECD-NEA HQ

International Nuclear Information System (INIS)

Bischoff, Jeremy; Gandrille, Pascal; Forgeron, Thierry; Brachet, Jean-Christophe; Lorrette, Christophe; Valot, C.; Freyss, M.; Braun, J.; Sauder, C.; Moatti, Marie; Waeckel, Nicolas; Ambard, Antoine; Pasamehmetoglu, Kemal; Johnston, Emma; Bragg-Sitton, Shannon M.; Kurata, M.; Hallstadius, Lars; Ohta, H.; Ogata, T.; Besmann, T.; Chauvin, Nathalie; Cornet, Stephanie; Massara, S.; Kohyama, Akira; Kishimoto, Hirotatsu; Park, Joon Soo; Nakazato, Naofumi; Hayasaka, Daisuke; Asakura, Yuuki; Kanda, Chisato; Kohyama, Akira; Terrani, Kurt; Katoh, Yutai; Yamamoto, Yukinori; Field, Kevin; Snead, Lance; Hu, Xunxiang; Dryepondt, Sebastien; Unocic, Kinga A.; Hoelzer, David T.; Pint, Bruce A.; Besmann, T.; Steinbrueck, M.; Grosse, M.; Jianu, A.; Weisenburger, A.; Avincola, V.; Ahmad, S.; Tang, C.; Heuser, Brent J.; Sickafus, Kurt; Kim, Hyun-Gil; Kim, Il-Hyun; Jung, Yang-Il; Park, Dong-Jun; Park, Jung-Hwan; Park, Jeong-Yong; Koo, Yang-Hyun; Lee, B.O.; Van Nieuwenhove, Rudi; Kim, Young; Rebak, Raul; Dolly, Evan; Dolley, E.J.; Rebak, R.B.; Maloy, Stu; Yang, Jae-Ho; Kim, Dong-Joo; Kim, Keon-Sik; Koo, Yang-Hyun; Lee, Won Jae; Tulenko, James S.; Puide, Mattias; Liu, T.; Gueneau, C.; Gosse, S.; Dupin, N.; Barber, D.; Corcoran, E.; Dumas, J.C.; Hania, R.; Kaye, M.; Turchi, P.

2015-03-01

Group on Multiscale Modeling of Fuels - M2F (S. Massara, NEA); - NSC/WPRS Activities on Reactor Fuel Performance - EGRFP, and IFPE database (S. Massara, NEA); 2 - Joint Task Force 2 (Cladding/core materials) and Task Force 3 (Fuel concepts) meeting, 3-4 March 2015: 2a - SiC and SiC/SiC composites: - Update on SIC/SIC projects in OASIS (A. Kohyama, Muroran Institute of Technology); - Systematic Technology Evaluation Plan for SiC/SiC: Execution Update (K. Terrani, ORNL); - SIC composite-based materials for enhanced accident tolerant fuel of LWRs: recent results on the chemical compatibility with UO 2 (J. Braun, CEA); 2b - Coated Zr-alloys: - Update of KIT activities on ATF claddings (M. Steinbrueck, KIT); - OECD NEA EGATFL Coatings sub-Task Force (B. Heuser, Univ. Illinois); - On-going R and D, update and some perspectives on chromium coated Zr based claddings for enhanced accident tolerant fuel of LWRs (J.C. Brachet, CEA); - Recent progress on surface modified Zr-alloy claddings (H.G. Kim, KAERI); - Status of testing of commercially available PVD coatings at the Halden Reactor Project (R. Van Nieuwenhove, OECD/Halden); 2c - Advanced Steels: - Development of Engineering Grade FeCrAl Alloys for Clad (K. Terrani, ORNL); - ODS steel data survey and analysis (2008-2014) (A. Kohyama, Muroran Institute of Technology); - Advanced ODS FeCrAl Alloys As Accident Tolerant Fuel Cladding (Sebastien Dryepondt et al.) - Ferritic Steels as Accident Tolerant Fuel Cladding for Commercial Light Water Reactors (E. Dolley, GE); 2d - Refractory metals: - Refractory Metal Cladding and Mo-alloy Development for Accident Tolerant Fuel (A. Sowder for Bo Cheng, EPRI); 2e - Improved UO 2 : - Recent progress on micro-cell UO 2 pellets (J.H. Yang, KAERI); - ATF Fuel - Enhanced UO 2 (J. Tulenko, Univ. Florida); 2f - High Density Fuel: - High density fuels (M. Puide, Westinghouse); 2g - Coated Particle Fuel: - Coated Particle Fuel FCM Replacement Fuel for LWRs (Y. Yang, KAERI); - Technology Readiness

Developing diagnostic guidelines for the acute radiation syndrome

International Nuclear Information System (INIS)

Densow, D.; Fliedner, T.M.; Kindler, H.

1996-01-01

Diagnostic guidelines seem to be promising for improving medical care. One aspect of a diagnostic guideline for the acute radiation syndrome has been tested against an extensive case history database. Subsequently, the guideline has been optimized for a small set of case histories. The improved performance has been proven by a test against the rest of the case history database

Twenty six-week exposure to 2 amino-3 methylimidazo [4,5-f]quinoline (IQ) does not significantly increase the incidence of tumours in HMGCR/mts1 tg579 transgenic mice

DEFF Research Database (Denmark)

Mortensen, Alicja; Lukanidin, E.; Ambartsumian, N.S.

2004-01-01

HMGCR/mtsl t9579 transgenic mice were designed to direct the expression of metastasis-promoting mts 1 (S100A4) gene to all the tissues. In order to test the usefulness of this mouse model for carcinogenicity tests shorter than that recommended by OECD guideline mr. 451, HMGCR/mtsl tg579 transgenic...

Et benchmark studie af menneskelige ressourcer på tværs af OECD-landene

DEFF Research Database (Denmark)

Klynge, Alice Heegaard; Riis, Annemarie Munk

and Finland make up the top 3 in terms of human resources. The three countries significantly outperform all other countries. At the same time the United States, Sweden and Finland have excellent framework conditions. Denmark’s performance in terms of human resources and the quality of framework conditions...... approach compared to other benchmarking methods. The FORA/OECD approach not only shows how countries perform in a specific area, it also tests the link between framework conditions and performance in the area of human resources. Based on available data the analysis shows that the United States, Sweden...... is solid. However, it will take an additional effort to bring Denmark in line with the top-performing countries....

The study for effective utilization on the nuclear information of OECD/NEA

International Nuclear Information System (INIS)

Ko, H. S.; Oh, K. B.; Lee, H. M.

2001-01-01

As a group of nuclear-advanced countries, the OECD/NEA mainly deals with the aspects of science and technology and future policy of nuclear energy. It is very important for us to develop nuclear advanced technology and enhance the global environemnt of nuclear utilization and development through the OECD/NEA. It is required for us to timely obtain and analyse the up-to-date nuclear technology information and to build up a system to collect and distribute nuclear technology information from NEA committees. In this study, measures for effective utilization of the NEA information have been established through the analysis of the activities of the experts meeting in each standing technical committee and of technology information. In this regard, it is also developed a homepage to disseminate reports from NEA Committees participants as one of the strengthening measures

OECD MMCI 2-D Core Concrete Interaction (CCI) tests : CCCI-1 test data report-thermalhydraulic results. Rev 0 January 31, 2004.

Energy Technology Data Exchange (ETDEWEB)

Farmer, M. T.; Lomperski, S.; Aeschlimann, R. W.; Basu, S. (Nuclear Engineering Division)

2011-05-23

The Melt Attack and Coolability Experiments (MACE) program addressed the issue of the ability of water to cool and thermally stabilize a molten core-concrete interaction when the reactants are flooded from above. These tests provided data regarding the nature of corium interactions with concrete, the heat transfer rates from the melt to the overlying water pool, and the role of noncondensable gases in the mixing processes that contribute to melt quenching. As a follow-on program to MACE, The Melt Coolability and Concrete Interaction Experiments (MCCI) project is conducting reactor material experiments and associated analysis to achieve the following objectives: (1) resolve the ex-vessel debris coolability issue through a program that focuses on providing both confirmatory evidence and test data for the coolability mechanisms identified in MACE integral effects tests, and (2) address remaining uncertainties related to long-term two-dimensional molten coreconcrete interactions under both wet and dry cavity conditions. Achievement of these two program objectives will demonstrate the efficacy of severe accident management guidelines for existing plants, and provide the technical basis for better containment designs for future plants. In terms of satisfying these objectives, the Management Board (MB) approved the conduct of two long-term 2-D Core-Concrete Interaction (CCI) experiments designed to provide information in several areas, including: (i) lateral vs. axial power split during dry core-concrete interaction, (ii) integral debris coolability data following late phase flooding, and (iii) data regarding the nature and extent of the cooling transient following breach of the crust formed at the melt-water interface. This data report provides thermal hydraulic test results from the CCI-1 experiment, which was conducted on December 19, 2003. Test specifications for CCI-1 are provided in Table 1-1. This experiment investigated the interaction of a fully oxidized 400 kg

OECD MCCI 2-D Core Concrete Interaction (CCI) tests : CCI-2 test data report-thermalhydraulic results, Rev. 0 October 15, 2004.

Energy Technology Data Exchange (ETDEWEB)

Farmer, M. T.; Lomperski, S.; Kilsdonk, D. J.; Aeschlimann, R. W.; Basu, S. (Nuclear Engineering Division); (NRC)

2011-05-23

The Melt Attack and Coolability Experiments (MACE) program addressed the issue of the ability of water to cool and thermally stabilize a molten core-concrete interaction when the reactants are flooded from above. These tests provided data regarding the nature of corium interactions with concrete, the heat transfer rates from the melt to the overlying water pool, and the role of noncondensable gases in the mixing processes that contribute to melt quenching. As a follow-on program to MACE, The Melt Coolability and Concrete Interaction Experiments (MCCI) project is conducting reactor material experiments and associated analysis to achieve the following objectives: (1) resolve the ex-vessel debris coolability issue through a program that focuses on providing both confirmatory evidence and test data for the coolability mechanisms identified in MACE integral effects tests, and (2) address remaining uncertainties related to long-term two-dimensional molten core-concrete interactions under both wet and dry cavity conditions. Achievement of these two program objectives will demonstrate the efficacy of severe accident management guidelines for existing plants, and provide the technical basis for better containment designs for future plants. In terms of satisfying these objectives, the Management Board (MB) approved the conduct of two long-term 2-D Core-Concrete Interaction (CCI) experiments designed to provide information in several areas, including: (i) lateral vs. axial power split during dry core-concrete interaction, (ii) integral debris coolability data following late phase flooding, and (iii) data regarding the nature and extent of the cooling transient following breach of the crust formed at the melt-water interface. This data report provides thermal hydraulic test results from the CCI-2 experiment, which was conducted on August 24, 2004. Test specifications for CCI-2 are provided in Table 1-1. This experiment investigated the interaction of a fully oxidized 400 kg

Cancer screening guidelines.

Science.gov (United States)

Zoorob, R; Anderson, R; Cefalu, C; Sidani, M

2001-03-15

Numerous medical organizations have developed cancer screening guidelines. Faced with the broad, and sometimes conflicting, range of recommendations for cancer screening, family physicians must determine the most reasonable and up-to-date method of screening. Major medical organizations have generally achieved consensus on screening guidelines for breast, cervical and colorectal cancer. For breast cancer screening in women ages 50 to 70, clinical breast examination and mammography are generally recommended every one or two years, depending on the medical organization. For cervical cancer screening, most organizations recommend a Papanicolaou test and pelvic examination at least every three years in patients between 20 and 65 years of age. Annual fecal occult blood testing along with flexible sigmoidoscopy at five-year to 10-year intervals is the standard recommendation for colorectal cancer screening in patients older than 50 years. Screening for prostate cancer remains a matter of debate. Some organizations recommend digital rectal examination and a serum prostate-specific antigen test for men older than 50 years, while others do not. In the absence of compelling evidence to indicate a high risk of endometrial cancer, lung cancer, oral cancer and ovarian cancer, almost no medical organizations have developed cancer screening guidelines for these types of cancer.

Aggregate Multi-Factor Productivity: Measurement Issues in OECD Countries

OpenAIRE

Egert, Balazs

2018-01-01

This paper analyses for 34 OECD countries the extent to which the calculation of aggregate multi-factor productivity (MFP) is sensitive to alternative parameterisations. The starting point is the definition of MFP used in previous work in the OECD’s Economics Department (e.g. Johansson et al. 2013). They include alternative MFP measures, with human capital included or excluded, with different measures of Purchasing Power Parity (PPP) exchange rates, using time-varying capital depreciation rat...

Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing.

Science.gov (United States)

Mandelker, Diana; Zhang, Liying; Kemel, Yelena; Stadler, Zsofia K; Joseph, Vijai; Zehir, Ahmet; Pradhan, Nisha; Arnold, Angela; Walsh, Michael F; Li, Yirong; Balakrishnan, Anoop R; Syed, Aijazuddin; Prasad, Meera; Nafa, Khedoudja; Carlo, Maria I; Cadoo, Karen A; Sheehan, Meg; Fleischut, Megan H; Salo-Mullen, Erin; Trottier, Magan; Lipkin, Steven M; Lincoln, Anne; Mukherjee, Semanti; Ravichandran, Vignesh; Cambria, Roy; Galle, Jesse; Abida, Wassim; Arcila, Marcia E; Benayed, Ryma; Shah, Ronak; Yu, Kenneth; Bajorin, Dean F; Coleman, Jonathan A; Leach, Steven D; Lowery, Maeve A; Garcia-Aguilar, Julio; Kantoff, Philip W; Sawyers, Charles L; Dickler, Maura N; Saltz, Leonard; Motzer, Robert J; O'Reilly, Eileen M; Scher, Howard I; Baselga, Jose; Klimstra, David S; Solit, David B; Hyman, David M; Berger, Michael F; Ladanyi, Marc; Robson, Mark E; Offit, Kenneth

2017-09-05

Guidelines for cancer genetic testing based on family history may miss clinically actionable genetic changes with established implications for cancer screening or prevention. To determine the proportion and potential clinical implications of inherited variants detected using simultaneous sequencing of the tumor and normal tissue ("tumor-normal sequencing") compared with genetic test results based on current guidelines. From January 2014 until May 2016 at Memorial Sloan Kettering Cancer Center, 10 336 patients consented to tumor DNA sequencing. Since May 2015, 1040 of these patients with advanced cancer were referred by their oncologists for germline analysis of 76 cancer predisposition genes. Patients with clinically actionable inherited mutations whose genetic test results would not have been predicted by published decision rules were identified. Follow-up for potential clinical implications of mutation detection was through May 2017. Tumor and germline sequencing compared with the predicted yield of targeted germline sequencing based on clinical guidelines. Proportion of clinically actionable germline mutations detected by universal tumor-normal sequencing that would not have been detected by guideline-directed testing. Of 1040 patients, the median age was 58 years (interquartile range, 50.5-66 years), 65.3% were male, and 81.3% had stage IV disease at the time of genomic analysis, with prostate, renal, pancreatic, breast, and colon cancer as the most common diagnoses. Of the 1040 patients, 182 (17.5%; 95% CI, 15.3%-19.9%) had clinically actionable mutations conferring cancer susceptibility, including 149 with moderate- to high-penetrance mutations; 101 patients tested (9.7%; 95% CI, 8.1%-11.7%) would not have had these mutations detected using clinical guidelines, including 65 with moderate- to high-penetrance mutations. Frequency of inherited mutations was related to case mix, stage, and founder mutations. Germline findings led to discussion or initiation of

Internprissättning och omkarakterisering : En studie av möjligheten att omkarakterisera gränsöverskridande transaktioner vid inkomstbeskattningen

OpenAIRE

Burmeister, Jari

2016-01-01

The purpose of the compilation thesis has been to compare the ability to recharacterize cross-border transactions under the OECD Transfer Pricing Guidelines, 2010 version (OECD Guidelines), and OECDs new guidance from the BEPS project 2015 (Final Report) with the possibility to reclassify legal transactions in accordance with Swedish domestic law. The latter is an interpretation of the Swedish Supreme Administrative Court’s (SAC) case law on the taxation of transactions based of their true im...

[Guidelines for the management of point-of care testing nonconformities according to the EN ISO 22870].

Science.gov (United States)

Houlbert, C; Annaix, V; Szymanowicz, A; Vassault, A; Guimont, M C; Pernet, P

2012-02-01

In this paper, guidelines are proposed to fulfill the requirements of EN ISO 22870 standard regarding the management of point-of-care testing (POCT) nonconformities. In the first part, the main nonconformities that may affect POCT are given, the means for resolution and the control of adverse events are proposed. In the second part, we propose recommendations in case of unavailability of a point-of-care testing device from the occurring of the adverse event, to the restarting of the device.

The influence of study design and sex-differences on results from developmental neurotoxicity studies of bisphenol A: implications for toxicity testing.

Science.gov (United States)

Beronius, Anna; Johansson, Niklas; Rudén, Christina; Hanberg, Annika

2013-09-06

Developmental neurotoxicity (DNT) of bisphenol A (BPA) has been investigated in a large number of studies. However, there are discrepancies in the results reported between the studies. The aim of this study was to identify and analyze factors that may contribute to these differences and to assess whether there are sex-differences in the sensitivity of certain endpoints or tests used in DNT-studies. Forty-four DNT studies of BPA were identified from the open literature. Details about study design and results from each study, as well as the criteria for DNT testing according to the standardized OECD test guideline (TG) 426, were collected in a database. This enabled systematic and detailed comparisons between studies as well as to the criteria and recommendations stated in TG 426. Multivariate analyses were also used to investigate how different factors of the study design contributed to differences in study results. The analyses showed behavioral effects were often observed for endpoints that are not required according to OECD TG 426, such as anxiety-related, social and sexual behaviors, especially at very low doses and in female offspring. On the other hand relatively few studies observed any effects on motor activity, which is commonly used in screening for neurotoxic effects in regulatory testing. However, varied and to some extent seemingly contradictory results have been reported in these studies, especially for endpoints related to motor activity and anxiety and exploration. Many studies were also poorly reported, limiting these analyses. No strong conclusions could be drawn from the multivariate analyses. A few factors of study design, such as the size of the dose and number of dose levels used and the use of litter or individual pup as statistical unit seemed to have some influence on study results. In conclusion, this analysis suggests that DNT-studies conducted according to the standardized OECD TG 426 may overlook sensitive effects of BPA, and possibly

Lessons learned from OECD/CSNI ISP on small break LOCA: final report

International Nuclear Information System (INIS)

1996-07-01

This document presents an overview of the results obtained from five recent OECD/CSNI International Standard Problems (ISPs) dealing with phenomenologies typical of Small Break LOCA in PWR nuclear power plants of western design. The experiment in four Integral test Facilities, Lobi, Spes, Bethsy and Lstf and the recorded data from a steam generator tube rupture transient in the Belgian PWR of Doel, were taken as reference for the calculations. Relevant hardware characteristics of the facilities and of the plant are firstly given, including the correlation between key thermalhydraulic phenomena and the reference experimental scenarios. A statistical evaluation of the general data connected with each ISP is then presented. The lessons learned from the ISPs are then considered. Four areas have been identified: code deficiencies and capabilities, scaling of the data, progress in code capabilities and various additional aspects

The CARE guidelines: consensus-based clinical case report guideline development.

Science.gov (United States)

Gagnier, Joel J; Kienle, Gunver; Altman, Douglas G; Moher, David; Sox, Harold; Riley, David

2014-01-01

A case report is a narrative that describes, for medical, scientific, or educational purposes, a medical problem experienced by one or more patients. Case reports written without guidance from reporting standards are insufficiently rigorous to guide clinical practice or to inform clinical study design. Develop, disseminate, and implement systematic reporting guidelines for case reports. We used a three-phase consensus process consisting of (1) pre-meeting literature review and interviews to generate items for the reporting guidelines, (2) a face-to-face consensus meeting to draft the reporting guidelines, and (3) post-meeting feedback, review, and pilot testing, followed by finalization of the case report guidelines. This consensus process involved 27 participants and resulted in a 13-item checklist-a reporting guideline for case reports. The primary items of the checklist are title, key words, abstract, introduction, patient information, clinical findings, timeline, diagnostic assessment, therapeutic interventions, follow-up and outcomes, discussion, patient perspective, and informed consent. We believe the implementation of the CARE (CAse REport) guidelines by medical journals will improve the completeness and transparency of published case reports and that the systematic aggregation of information from case reports will inform clinical study design, provide early signals of effectiveness and harms, and improve healthcare delivery. Copyright © 2014 Reproduced with permission of Global Advances in Health and Medicine. Published by Elsevier Inc. All rights reserved.

Summary of the OECD Environmental Outlook to 2050; Samenvatting OESO milieuverkenning tot 2050

Energy Technology Data Exchange (ETDEWEB)

Manders, A.J.G.

2012-03-15

The OECD Environmental Outlook to 2050 asks 'What will the next four decades bring?' Based on joint modelling by the OECD and the Netherlands Environmental Assessment Agency (PBL), it looks forward to the year 2050 to find out what demographic and economic trends might mean for the environment if the world does not adopt more ambitious green policies. It also looks at what policies could change that picture for the better. This Outlook focuses on four areas: climate change, biodiversity, freshwater and health impacts of pollution. These four key environmental challenges were identified by the previous Environmental Outlook to 2030 (OECD, 2008) as 'Red Light' issues requiring urgent attention [Dutch] De Organisatie voor Economische Samenwerking en Ontwikkeling (OESO) maakt milieuverkenningen om beleidsmakers beter inzicht te geven in de schaal en samenhang van toekomstige uitdagingen rond milieu. De OESO maakt daarbij gebruik van modellen om projecties te maken. Voor deze verkenning is intensief samengewerkt met het Planbureau voor de Leefomgeving (PBL). De milieuverkenning tot 2050 verkent de gevolgen voor het milieu als meer ambitieuze maatregelen voor het beheer van onze natuurlijke hulpbronnen uitblijven. De verkenning stelt beleidsmaatregelen voor die deze situatie zouden kunnen verbeteren en richt zich op de vier meest urgente thema's: klimaatverandering, biodiversiteit, water en de gezondheidsimplicaties van vervuiling.

OECD: Eesti tööandjad võiks haigushüvitist pikemalt maksta / Christopher Prinz ; intervjueerinud Laura Raus

Index Scriptorium Estoniae

Prinz, Christopher

2011-01-01

Paljudes OECD riikides on toimunud nihe töötuselt töövõimetusele. OECD ekspert leiab, et töövõimetuspensionäride arvu alandamiseks võiks pikendada perioodi, mille kestel maksab töötajale haigushüvitist tööandja ja et osalise töövõimetusega inimesi võiks käsitleda tavalise töötuna

Guidelines for the Interpretation of Results of Microbiological Testing of Ready-to-Eat Foods Placed on the Market (Revision 2)

OpenAIRE

Food Safety Authority of Ireland

2016-01-01

This document provides guideline microbiological limits for ready-to-eat foods placed on the market. These guideline limits can be used if legal microbiological criteria (Appendix 1) do not exist for a particular combination of food and microorganism. This Guidance Note is intended to be used by: • Food business operators • Enforcement officers, and • Laboratories performing microbiological testing on ready-to-eat foods Food business operators may also use the limits prese...

The comet assay in testing the potential genotoxicity of nanomaterials

Directory of Open Access Journals (Sweden)

Amaya Azqueta

2015-06-01

Full Text Available In the last two decades the production and use of nanomaterials (NMs has impressively increased. Their small size, given a mass equal to that of the corresponding bulk material, implies an increase in the surface area and consequently in the number of atoms that can be reactive. They possess different physical, chemical and biological properties compared to bulk materials of the same composition, which makes them very interesting and valuable for many different applications in technology, energy, construction, electronics, agriculture, optics, paints, textiles, food, cosmetics, medicine... Toxicological assessment of NMs is crucial; the same properties that make them interesting also make them potentially harmful for health and the environment. However, the term NM covers many different kinds of particle , and so there is no simple, standard approach to assessing their toxicity. NMs can enter the cell, interact with cell components and even penetrate the nucleus and interfere with the genetic material. Among the different branches of toxicology, genotoxicity is a main area of concern since it is closely related with the carcinogenic potential of compounds. The Organisation for Economic Co-operation and Development (OECD has published internationally agreed in vitro and in vivo validated test methods to evaluate different genotoxic endpoints of chemicals, including chromosome and gene mutations, and DNA breaks. However not all the assays are suitable to study the genotoxic potential of NMs as has been shown by the OECD Working Party on Manufactured Nanomaterials (WPMN. Moreover, alterations to DNA bases, which are precursors to mutations and of great importance in elucidating the mechanism of action of NMs, are not covered by the OECD guidelines. The in vivo standard comet assay (which measures DNA breaks and alkali-labile sites was included in the OECD assays battery in September 2014 while the in vitro standard comet assay is currently under

Productivity Levels in Distributive Trades : A New ICOP Dataset for OECD Countries

NARCIS (Netherlands)

Timmer, Marcel P.; Ypma, Gerard

2006-01-01

This study provides a new dataset for international comparisons of labour productivity levels in distributive trade (retail and wholesale trade) between OECD countries. The productivity level comparisons are based on a harmonised set of Purchasing Power Parities (PPPs) for 1997 using the

The IMAGE model suite used for the OECD Environmental Outlook to 2050

Energy Technology Data Exchange (ETDEWEB)

Kram, T.; Stehfest, E.

2012-03-15

In the Environmental Outlook to 2050 from the Organisation for Economic Co-operation and Development (OECD) a number of scenarios and projection are used which are calculated with the IMAGE model suite. This document describes the models and modules used and their interconnections.

Supporting Entrepreneurship and Innovation in Higher Education in Ireland. OECD Skills Studies

Science.gov (United States)

OECD Publishing, 2017

2017-01-01

This report presents evidence-based analysis on Ireland's higher education transformation process towards an innovative, interconnected and multidisciplinary entrepreneurial system, designed to empower its students and staff to demonstrate enterprise, innovation and creativity in teaching, research and societal engagement. Using the OECD-European…

Supporting Entrepreneurship and Innovation in Higher Education in Poland. OECD Skills Studies

Science.gov (United States)

OECD Publishing, 2017

2017-01-01

This report presents evidence-based analysis on Poland's higher education transformation process towards an innovative, interconnected and multidisciplinary entrepreneurial system, designed to empower its students and staff to demonstrate enterprise, innovation and creativity in teaching, research and societal engagement. Using the OECD-European…

Hypertension guidelines and their effects on the health system

Directory of Open Access Journals (Sweden)

Konta, Brigitte

2005-12-01

existing literature at the present time. One can assume from international studies with analogical reasoning that these are confessed and have a high level of acceptance in the medical community. Unfortunately the actual usage is not represented satisfactorily in the scientific literature. The effects of the guidelines on the medical procedures seem to be very strongly individual and the analyses to the compliance show at least an observable effect within the last few years. No publications could be found for the cost effectiveness of the guidelines. The actual compliance with guidelines seems to be in relation with the duration of the professional practice. It seems the shorter the professional practice takes place, the stronger the guidelines are adhered. Discussion: At present, there are only a few notes for the German health service regarding the actual effect of the hypertonus guidelines. However, the reason is not that the effect would not be possibly strong but at the methodical challenge to evaluate the sustaining effects of the application of the hypertonus guidelines. For this reason the literature is very rare regarding this topic. For Germany it can be derived by analogical reasoning from foreign studies that guidelines will facilitate a more and more essential contribution to the design of the health system. Considering that primarily younger physicians accepted guidelines mode, the further construction, update and implementation of guidelines are essential, particularly with regard to the quality assurance. Straight guidelines can express a standard of the quality of a health system as a benchmark. The existence of guidelines or the lack thereof is considered also as a quality indicator of a health system at the organisation for economic cooperation and development (OECD. Conclusion: Guidelines should be evaluated - especially the hypertonus guideline. Also further development and implementation should be emphasised. Methodically oriented work to the approach

Data Qualification guidelines

International Nuclear Information System (INIS)

Edwards, T.B.; Shine, E.P.

1992-01-01

Data Qualification (DQ) is a formal, technical process whose objective is to affirm that experimental data are suitable for their intended use. Although it is not possible to develop a fixed recipe for the DQ process to cover all test situations, these general guidelines have been developed for the Nuclear Engineering Section to establish a framework for qualifying data from steady-state processing. These guidelines outline the role of the DQ team providing insight into the planning and conducting of the DQ process

Consumers, Industrialists and the Political Economy of Green Taxation: CO2 taxation in OECD

DEFF Research Database (Denmark)

Svendsen, Gert Tinggaard; Daugbjerg, Carsten; Hjøllund, Lene

2001-01-01

Economists have traditionally suggested that politicians should simply impose a uniform tax on harmful emissions, as the first-best solution prescribes. However, a detailed analysis of the actual design of green taxes in the OECD reveals that they are differentiated and far from this first......-best optimal design. Public choice theory suggests that an important reason this is so is that industry as a group, in contrast to households, is capable of lobbying against green taxation. The paper presents empirical findings on CO2 taxation within the OECD countries, which confirm this theoretical......) and grandfathered permit markets (in relation to organized interests) should be considered in the search for cost-effective and politically feasible instruments. Udgivelsesdato: MAY...

The OECD-BEPS Measures to Deal with Aggressive Tax Planning in South America and Sub-Saharan Africa : The Challenges Ahead

NARCIS (Netherlands)

Mosquera, Valderrama I.J.

2015-01-01

The aim of this article is to assess the feasibility to introduce the Organisation for Economic Co-operation and Development (OECD)-BEPS measures to deal with aggressive tax planning in South America and Sub-Saharan Africa. The BEPS and its Action Plan have been developed by the OECD following

Andorra: exchange of information and new tax system in the context of the OECD's and EU's initiatives

OpenAIRE

Vega García, Alberto

2015-01-01

Andorra, a microstate located in the Pyrenees, between France and Spain, used to be characterized by strict bank secrecy and the absence of direct taxes on income. However, given the pressure exerted by the European Union and, especially, by the OECD, Andorra finally committed in 2009 to exchanging tax information upon request according to the OECD standards. Since then, Andorra has introduced important legal reforms following these standards, in a process which is still evolving and which ma...

Globalization, female employment, and regional differences in OECD countries

OpenAIRE

Fischer, Justina A.V.

2013-01-01

Accounting for within-country spatial differences is a much neglected issue in many cross-country comparisons. This paper highlights this importance in this empirical analysis of the impact of a country’s degree of social and economic globalization on female employment in 33 OECD countries, using a pseudo micro panel on 110’000 persons from the World Values Survey, 1981 to 2008. A traditional cross-country analysis suggests that only the social dimension of globalization, the worldwide inform...

Solid-phase microextraction for bioconcentration studies according to OECD TG 305

Energy Technology Data Exchange (ETDEWEB)

Duering, Rolf-Alexander; Boehm, Leonard [Land Use and Nutrition (IFZ) Justus Liebig University Giessen, Institute of Soil Science and Soil Conservation, Research Centre for BioSystems, Giessen (Germany); Schlechtriem, Christian [Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Schmallenberg (Germany)

2012-12-15

An important aim of the European Community Regulation on chemicals and their safe use is the identification of (very) persistent, (very) bioaccumulative, and toxic substances. In other regulatory chemical safety assessments (pharmaceuticals, biocides, pesticides), the identification of such (very) persistent, (very) bioaccumulative, and toxic substances is of increasing importance. Solid-phase microextraction is especially capable of extracting total water concentrations as well as the freely dissolved fraction of analytes in the water phase, which is available for bioconcentration in fish. However, although already well established in environmental analyses to determine and quantify analytes mainly in aqueous matrices, solid-phase microextraction is still a rather unusual method in regulatory ecotoxicological research. Here, the potential benefits and drawbacks of solid-phase microextraction are discussed as an analytical routine approach for aquatic bioconcentration studies according to OECD TG 305, with a special focus on the testing of hydrophobic organic compounds characterized by log K{sub OW}> 5. (orig.)

Anomaly detection in OECD Benchmark data using co-variance methods

International Nuclear Information System (INIS)

Srinivasan, G.S.; Krinizs, K.; Por, G.

1993-02-01

OECD Benchmark data distributed for the SMORN VI Specialists Meeting in Reactor Noise were investigated for anomaly detection in artificially generated reactor noise benchmark analysis. It was observed that statistical features extracted from covariance matrix of frequency components are very sensitive in terms of the anomaly detection level. It is possible to create well defined alarm levels. (R.P.) 5 refs.; 23 figs.; 1 tab

Taxation and the household saving rate: evidence from OECD countries

Directory of Open Access Journals (Sweden)

Vito Tanzi

2000-03-01

Full Text Available This paper analyzes anew the relationship between taxation and the household saving rate. On the basis of standard savings and tax revenue data from a sample of OECD countries, it provides compelling empirical evidence of a powerful impact of taxes on household savings. In particular, income taxes are shown to affect negatively the household saving rate much more than consumption taxes.

The main outcomes of the OECD Behaviour of Iodine (BIP) Project

International Nuclear Information System (INIS)

Glowa, Glenn A.; Moore, Chris J.; Ball, Joanne M.

2013-01-01

Highlights: • Moisture affects the rate of iodine adsorption on paint. • Irradiation of iodine-loaded paint yields methyl iodide. • The BIP project is complimentary to the EPICUR project. • BIP results help with the interpretation of Phébus FP results. - Abstract: An Organisation for Economic Co-operation and Development (OECD) status report on iodine behaviour published in February 2007 concluded that although the understanding of iodine behaviour in containment had advanced considerably over the past several decades, there were still areas where further investigation was warranted. The OECD initiated the Behaviour of Iodine Project (BIP) to investigate two of these areas: • The interaction of iodine with painted surfaces: adsorption of iodine from the gas phase to several containment surfaces was investigated under a variety of conditions, with focus on the role of water on the adsorption of iodine onto epoxy paints. The results show that the relative humidity is very important to the deposition velocity of iodine on paint; higher humidity caused faster deposition. Adsorption parameters are a critical input for containment codes. • The formation of organic iodide from painted surfaces: gas chromatography was used to monitor the evolution of CH 3 I during the irradiation of epoxy coupons pre-loaded with iodine. The results showed that organic iodide formation is greater, and has a different temporal behaviour, when the iodine is absorbed by the paint from the aqueous phase as opposed to from the gas phase. The results also highlighted the importance of destruction of organic iodides by gas phase radiolysis to the concentration of CH 3 I. The BIP organic iodide production experiments were different, but complementary, to the experiments performed in the EPICUR (Experimental Program for Iodine Chemistry Under Radiation) facility. However, both projects share an objective of supporting the explanation of iodine behaviour in the Phébus Fission Product

Use of OECD/NEA Data Project Products in Probabilistic Safety Assessment

International Nuclear Information System (INIS)

Cherkas, G.; Raducu, Gheorghe; Riznic, J.; Yalaoui, S.; Huang, Hui-Wen; Holy, Jaroslav; Holmberg, Jan-Erik; Sandberg, Jorma; Balmain, Michel; Bonnevialle, Anne-Marie; Curnier, Florence; Georgescu, Gabriel; Lanore, Jeanne-Marie; Lindner, Arndt; Fujimoto, Haruo; Ahn, Kwang-Il; Hwang, Taesuk; Jang, Seung-Cheol; Husarcek, Jan; Kovacs, Zoltan; Vazquez, Teresa; Johanson, Gunnar; Liwaang, Bo; Nyman, Ralph; Dang, Vinh; Schoen, Gerhard; Brook, Kevin; Hamblen, David; Siu, Nathan; Sturzebecher, Karl; Tobin, Margaret; Wood, Jeff; Amri, Abdallah; Breest, Axel

2014-01-01

The Nuclear Energy Agency (NEA)/Committee for the Safety of Nuclear Installations' (CSNI) Working Group on Risk Assessment (WGRISK) is tasked with supporting the improved use of Probabilistic Safety Assessment (PSA) in risk informed regulation and safety management through the analysis of results and the development of perspectives regarding potentially important risk contributors and associated risk reduction strategies. The task consists of the following major activities: Development, distribution, and completion of survey questionnaires; Analysis of survey questionnaire results at a task workshop; Preparation of the final task report. The main objectives of this task, as proposed by WGRISK and approved by CSNI, are the following: - Identification and characterization of the current uses of OECD data project products and data in support of PSA. In this context, the term 'products' refers to data analysis results, technical reports, and other project outputs. - Identification and characterization of technical and programmatic characteristics that either support or impede use of data project products in PSA. This includes an assessment of which PSA parameters could be potentially estimated from the various data project products and gaps between available product information and PSA data needs. - Identification of recommendations for enhancing the usefulness of data project products and the coordination between WGRISK and the data projects. This task report consists of the following sections: - Chapter 1 Provides a general overview of motivation and approach used for this task. - Chapter 2 Describes scope and objectives of the task. - Chapter 3 Provides an overview of the ICDE, FIRE, OPDE/CODAP, and COMPSIS data projects. For each project, the project objectives, project history, data collection methodology and quality assurance, project status, example PSA Applications, and information related to project participation is provided. - Chapter 4 Describes the

Comparison of test specific sediment effect concentrations with marine sediment quality assessment guidelines

International Nuclear Information System (INIS)

Carr, R.S.; Biedenbach, J.M.; MacDonald, D.D.

1995-01-01

As part of NOAA's National Status and Trends (NS and T) Bioeffects Assessment program and studies conducted by the National Biological Service, numerous sediment quality assessment surveys have recently been conducted along the Atlantic and Gulf coasts of the US using the sea urchin (Arbacia punctulata) fertilization and embryological development tests with pore water. Additional toxicity tests were also conducted in conjunction with most of these studies. The areas that have been sampled include Boston harbor, Massachusetts; Charleston Harbor, Winyah Bay, and Savannah River, South Carolina; St. Simon Sound, Georgia; Biscayne Bay, Tampa Bay, Choctawhatchee Bay, Apalachicola Bay, St. Andrew Bay, and Pensacola Bay, Florida; Galveston Bay, Lavaca Bay, and Sabine Lake, Texas, and 200 stations in the vicinity of offshore oil and gas production platforms in the Gulf of Mexico. Sufficient data are now available from this series of surveys to calculate test specific sediment effect concentrations (SECs). Based on these recent studies, SECs were developed for the sea urchin porewater and amphipod tests and compared with existing marine sediment quality assessment guidelines

Main-coolant-pump shaft-seal guidelines. Volume 3. Specification guidelines. Final report