WorldWideScience

Sample records for objective previous studies

  1. Determining root correspondence between previously and newly detected objects

    Science.gov (United States)

    Paglieroni, David W.; Beer, N Reginald

    2014-06-17

    A system that applies attribute and topology based change detection to networks of objects that were detected on previous scans of a structure, roadway, or area of interest. The attributes capture properties or characteristics of the previously detected objects, such as location, time of detection, size, elongation, orientation, etc. The topology of the network of previously detected objects is maintained in a constellation database that stores attributes of previously detected objects and implicitly captures the geometrical structure of the network. A change detection system detects change by comparing the attributes and topology of new objects detected on the latest scan to the constellation database of previously detected objects.

  2. Attribute and topology based change detection in a constellation of previously detected objects

    Science.gov (United States)

    Paglieroni, David W.; Beer, Reginald N.

    2016-01-19

    A system that applies attribute and topology based change detection to networks of objects that were detected on previous scans of a structure, roadway, or area of interest. The attributes capture properties or characteristics of the previously detected objects, such as location, time of detection, size, elongation, orientation, etc. The topology of the network of previously detected objects is maintained in a constellation database that stores attributes of previously detected objects and implicitly captures the geometrical structure of the network. A change detection system detects change by comparing the attributes and topology of new objects detected on the latest scan to the constellation database of previously detected objects.

  3. On the Tengiz petroleum deposit previous study

    International Nuclear Information System (INIS)

    Nysangaliev, A.N.; Kuspangaliev, T.K.

    1997-01-01

    Tengiz petroleum deposit previous study is described. Some consideration about structure of productive formation, specific characteristic properties of petroleum-bearing collectors are presented. Recommendation on their detail study and using of experience on exploration and development of petroleum deposit which have analogy on most important geological and industrial parameters are given. (author)

  4. An unbinding problem? The disintegration of visible, previously attended objects does not attract attention.

    Science.gov (United States)

    Wolfe, Jeremy M; Oliva, Aude; Butcher, Serena J; Arsenio, Helga C

    2002-01-01

    In seven experiments, observers searched for a scrambled object among normal objects. The critical comparison was between repeated search in which the same set of stimuli remained present in fixed positions in the display for many (>100) trials and unrepeated conditions in which new stimuli were presented on each trial. In repeated search conditions, observers monitored an essentially stable display for the disruption of a clearly visible object. This is an extension of repeated search experiments in which subjects search a fixed set of items for different targets on each trial (Wolfe, Klempen, & Dahlen, 2000) and can be considered as a form of a "change blindness" task. The unrepeated search was very inefficient, showing that a scrambled object does not "pop-out" among intact objects (or vice versa). Interestingly, the repeated search condition was just as inefficient, as if participants had to search for the scrambled target even after extensive experience with the specific change in the specific scene. The results suggest that the attentional processes involved in searching for a target in a novel scene may be very similar to those used to confirm the presence of a target in a familiar scene.

  5. Personality disorders in previously detained adolescent females: a prospective study

    NARCIS (Netherlands)

    Krabbendam, A.; Colins, O.F.; Doreleijers, T.A.H.; van der Molen, E.; Beekman, A.T.F.; Vermeiren, R.R.J.M.

    2015-01-01

    This longitudinal study investigated the predictive value of trauma and mental health problems for the development of antisocial personality disorder (ASPD) and borderline personality disorder (BPD) in previously detained women. The participants were 229 detained adolescent females who were assessed

  6. The association between subjective memory complaint and objective cognitive function in older people with previous major depression.

    Science.gov (United States)

    Chu, Chung-Shiang; Sun, I-Wen; Begum, Aysha; Liu, Shen-Ing; Chang, Ching-Jui; Chiu, Wei-Che; Chen, Chin-Hsin; Tang, Hwang-Shen; Yang, Chia-Li; Lin, Ying-Chin; Chiu, Chih-Chiang; Stewart, Robert

    2017-01-01

    The goal of this study is to investigate associations between subjective memory complaint and objective cognitive performance in older people with previous major depression-a high-risk sample for cognitive impairment and later dementia. A cross-sectional study was carried out in people aged 60 or over with previous major depression but not fulfilling current major depression criteria according to DSM-IV-TR. People with dementia or Mini-Mental State Examination score less than 17 were excluded. Subjective memory complaint was defined on the basis of a score ≧4 on the subscale of Geriatric Mental State schedule, a maximum score of 8. Older people aged equal or over 60 without any psychiatric diagnosis were enrolled as healthy controls. Cognitive function was evaluated using a series of cognitive tests assessing verbal memory, attention/speed, visuospatial function, verbal fluency, and cognitive flexibility in all participants. One hundred and thirteen older people with previous major depression and forty-six healthy controls were enrolled. Subjective memory complaint was present in more than half of the participants with depression history (55.8%). Among those with major depression history, subjective memory complaint was associated with lower total immediate recall and delayed verbal recall scores after adjustment. The associations between subjective memory complaint and worse memory performance were stronger in participants with lower depressive symptoms (Hamilton Depression Rating Scale scorememory complaint may be a valid appraisal of memory performance in older people with previous major depression and consideration should be given to more proactive assessment and follow-up in these clinical samples.

  7. The association between subjective memory complaint and objective cognitive function in older people with previous major depression.

    Directory of Open Access Journals (Sweden)

    Chung-Shiang Chu

    Full Text Available The goal of this study is to investigate associations between subjective memory complaint and objective cognitive performance in older people with previous major depression-a high-risk sample for cognitive impairment and later dementia. A cross-sectional study was carried out in people aged 60 or over with previous major depression but not fulfilling current major depression criteria according to DSM-IV-TR. People with dementia or Mini-Mental State Examination score less than 17 were excluded. Subjective memory complaint was defined on the basis of a score ≧4 on the subscale of Geriatric Mental State schedule, a maximum score of 8. Older people aged equal or over 60 without any psychiatric diagnosis were enrolled as healthy controls. Cognitive function was evaluated using a series of cognitive tests assessing verbal memory, attention/speed, visuospatial function, verbal fluency, and cognitive flexibility in all participants. One hundred and thirteen older people with previous major depression and forty-six healthy controls were enrolled. Subjective memory complaint was present in more than half of the participants with depression history (55.8%. Among those with major depression history, subjective memory complaint was associated with lower total immediate recall and delayed verbal recall scores after adjustment. The associations between subjective memory complaint and worse memory performance were stronger in participants with lower depressive symptoms (Hamilton Depression Rating Scale score<7. The results suggest subjective memory complaint may be a valid appraisal of memory performance in older people with previous major depression and consideration should be given to more proactive assessment and follow-up in these clinical samples.

  8. Radon anomalies prior to earthquakes (1). Review of previous studies

    International Nuclear Information System (INIS)

    Ishikawa, Tetsuo; Tokonami, Shinji; Yasuoka, Yumi; Shinogi, Masaki; Nagahama, Hiroyuki; Omori, Yasutaka; Kawada, Yusuke

    2008-01-01

    The relationship between radon anomalies and earthquakes has been studied for more than 30 years. However, most of the studies dealt with radon in soil gas or in groundwater. Before the 1995 Hyogoken-Nanbu earthquake, an anomalous increase of atmospheric radon was observed at Kobe Pharmaceutical University. The increase was well fitted with a mathematical model related to earthquake fault dynamics. This paper reports the significance of this observation, reviewing previous studies on radon anomaly before earthquakes. Groundwater/soil radon measurements for earthquake prediction began in 1970's in Japan as well as foreign countries. One of the most famous studies in Japan is groundwater radon anomaly before the 1978 Izu-Oshima-kinkai earthquake. We have recognized the significance of radon in earthquake prediction research, but recently its limitation was also pointed out. Some researchers are looking for a better indicator for precursors; simultaneous measurements of radon and other gases are new trials in recent studies. Contrary to soil/groundwater radon, we have not paid much attention to atmospheric radon before earthquakes. However, it might be possible to detect precursors in atmospheric radon before a large earthquake. In the next issues, we will discuss the details of the anomalous atmospheric radon data observed before the Hyogoken-Nanbu earthquake. (author)

  9. Treatment of Previously Treated Facial Capillary Malformations: Results of Single-Center Retrospective Objective 3-Dimensional Analysis of the Efficacy of Large Spot 532 nm Lasers.

    Science.gov (United States)

    Kwiek, Bartłomiej; Ambroziak, Marcin; Osipowicz, Katarzyna; Kowalewski, Cezary; Rożalski, Michał

    2018-06-01

    Current treatment of facial capillary malformations (CM) has limited efficacy. To assess the efficacy of large spot 532 nm lasers for the treatment of previously treated facial CM with the use of 3-dimensional (3D) image analysis. Forty-three white patients aged 6 to 59 were included in this study. Patients had 3D photography performed before and after treatment with a 532 nm Nd:YAG laser with large spot and contact cooling. Objective analysis of percentage improvement based on 3D digital assessment of combined color and area improvement (global clearance effect [GCE]) were performed. The median maximal improvement achieved during the treatment (GCE) was 59.1%. The mean number of laser procedures required to achieve this improvement was 6.2 (range 1-16). Improvement of minimum 25% (GCE25) was achieved by 88.4% of patients, a minimum of 50% (GCE50) by 61.1%, a minimum of 75% (GCE75) by 25.6%, and a minimum of 90% (GCE90) by 4.6%. Patients previously treated with pulsed dye lasers had a significantly less response than those treated with other modalities (GCE 37.3% vs 61.8%, respectively). A large spot 532 nm laser is effective in previously treated patients with facial CM.

  10. A longitudinal study of plasma insulin and glucagon in women with previous gestational diabetes

    DEFF Research Database (Denmark)

    Damm, P; Kühl, C; Hornnes, P

    1995-01-01

    OBJECTIVE: To investigate whether plasma insulin or glucagon predicts later development of diabetes in women with gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: The subjects studied were 91 women with diet-treated GDM and 33 healthy women. Plasma insulin and glucagon during a 50...... at follow-up (2 had insulin-dependent diabetes mellitus, 13 had non-insulin-dependent diabetes mellitus, and 12 had impaired glucose tolerance). Compared with the control subjects, women with previous GDM had relatively impaired insulin secretion (decreased insulinogenic index and delayed peak insulin...... for subsequent development of overt diabetes (logistic regression analysis). CONCLUSIONS: Women who develop GDM have a relative insulin secretion deficiency, the severity of which is predictive for later development of diabetes. Furthermore, our data indicate that their relatively reduced beta-cell function may...

  11. 40 CFR 152.93 - Citation of a previously submitted valid study.

    Science.gov (United States)

    2010-07-01

    ... Data Submitters' Rights § 152.93 Citation of a previously submitted valid study. An applicant may demonstrate compliance for a data requirement by citing a valid study previously submitted to the Agency. The... the original data submitter, the applicant may cite the study only in accordance with paragraphs (b...

  12. Connection-based and object-based grouping in multiple-object tracking: A developmental study.

    Science.gov (United States)

    Van der Hallen, Ruth; Reusens, Julie; Evers, Kris; de-Wit, Lee; Wagemans, Johan

    2018-03-30

    Developmental research on Gestalt laws has previously revealed that, even as young as infancy, we are bound to group visual elements into unitary structures in accordance with a variety of organizational principles. Here, we focus on the developmental trajectory of both connection-based and object-based grouping, and investigate their impact on object formation in participants, aged 9-21 years old (N = 113), using a multiple-object tracking paradigm. Results reveal a main effect of both age and grouping type, indicating that 9- to 21-year-olds are sensitive to both connection-based and object-based grouping interference, and tracking ability increases with age. In addition to its importance for typical development, these results provide an informative baseline to understand clinical aberrations in this regard. Statement of contribution What is already known on this subject? The origin of the Gestalt principles is still an ongoing debate: Are they innate, learned over time, or both? Developmental research has revealed how each Gestalt principle has its own trajectory and unique relationship to visual experience. Both connectedness and object-based grouping play an important role in object formation during childhood. What does this study add? The study identifies how sensitivity to connectedness and object-based grouping evolves in individuals, aged 9-21 years old. Using multiple-object tracking, results reveal that the ability to track multiple objects increases with age. These results provide an informative baseline to understand clinical aberrations in different types of grouping. © 2018 The Authors. British Journal of Developmental Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society.

  13. Summary of Previous Chamber or Controlled Anthrax Studies and Recommendations for Possible Additional Studies

    Energy Technology Data Exchange (ETDEWEB)

    Piepel, Gregory F.; Amidan, Brett G.; Morrow, Jayne B.

    2010-12-29

    This report and an associated Excel file(a) summarizes the investigations and results of previous chamber and controlled studies(b) to characterize the performance of methods for collecting, storing and/or transporting, extracting, and analyzing samples from surfaces contaminated by Bacillus anthracis (BA) or related simulants. This report and the Excel are the joint work of the Pacific Northwest National Laboratory (PNNL) and the National Institute of Standards and Technology (NIST) for the Department of Homeland Security, Science and Technology Directorate. The report was originally released as PNNL-SA-69338, Rev. 0 in November 2009 with limited distribution, but was subsequently cleared for release with unlimited distribution in this Rev. 1. Only minor changes were made to Rev. 0 to yield Rev. 1. A more substantial update (including summarizing data from other studies and more condensed summary tables of data) is underway

  14. Fire Risk Scoping Study: Investigation of nuclear power plant fire risk, including previously unaddressed issues

    International Nuclear Information System (INIS)

    Lambright, J.A.; Nowlen, S.P.; Nicolette, V.F.; Bohn, M.P.

    1989-01-01

    An investigation of nuclear power plant fire risk issues raised as a result of the USNRC sponsored Fire Protection Research Program at Sandia National Laboratories has been performed. The specific objectives of this study were (1) to review and requantify fire risk scenarios from four fire probabilistic risk assessments (PRAs) in light of updated data bases made available as a result of USNRC sponsored Fire Protection Research Program and updated computer fire modeling capabilities, (2) to identify potentially significant fire risk issues that have not been previously addressed in a fire risk context and to quantify the potential impact of those identified fire risk issues where possible, and (3) to review current fire regulations and plant implementation practices for relevance to the identified unaddressed fire risk issues. In performance of the fire risk scenario requantifications several important insights were gained. It was found that utilization of a more extensive operational experience base resulted in both fire occurrence frequencies and fire duration times (i.e., time required for fire suppression) increasing significantly over those assumed in the original works. Additionally, some thermal damage threshold limits assumed in the original works were identified as being nonconservative based on more recent experimental data. Finally, application of the COMPBRN III fire growth model resulted in calculation of considerably longer fire damage times than those calculated in the original works using COMPBRN I. 14 refs., 2 figs., 16 tabs

  15. Matched cohort study of external cephalic version in women with previous cesarean delivery.

    Science.gov (United States)

    Keepanasseril, Anish; Anand, Keerthana; Soundara Raghavan, Subrahmanian

    2017-07-01

    To evaluate the efficacy and safety of external cephalic version (ECV) among women with previous cesarean delivery. A retrospective study was conducted using data for women with previous cesarean delivery and breech presentation who underwent ECV at or after 36 weeks of pregnancy during 2011-2016. For every case, two multiparous women without previous cesarean delivery who underwent ECV and were matched for age and pregnancy duration were included. Characteristics and outcomes were compared between groups. ECV was successful for 32 (84.2%) of 38 women with previous cesarean delivery and 62 (81.6%) in the control group (P=0.728). Multivariate regression analysis confirmed that previous cesarean was not associated with ECV success (odds ratio 1.89, 95% confidence interval 0.19-18.47; P=0.244). Successful vaginal delivery after successful ECV was reported for 19 (59.4%) women in the previous cesarean delivery group and 52 (83.9%) in the control group (P<0.001). No ECV-associated complications occurred in women with previous cesarean delivery. To avoid a repeat cesarean delivery, ECV can be offered to women with breech presentation and previous cesarean delivery who are otherwise eligible for a trial of labor. © 2017 International Federation of Gynecology and Obstetrics.

  16. Teaching Object Permanence: An Action Research Study

    Science.gov (United States)

    Bruce, Susan M.; Vargas, Claudia

    2013-01-01

    "Object permanence," also known as "object concept" in the field of visual impairment, is one of the most important early developmental milestones. The achievement of object permanence is associated with the onset of representational thought and language. Object permanence is important to orientation, including the recognition of landmarks.…

  17. Empirical study on mutual fund objective classification.

    Science.gov (United States)

    Jin, Xue-jun; Yang, Xiao-lan

    2004-05-01

    Mutual funds are usually classified on the basis of their objectives. If the activities of mutual funds are consistent with their stated objectives, investors may look at the latter as signals of their risks and incomes. This work analyzes mutual fund objective classification in China by statistical methods of distance analysis and discriminant analysis; and examines whether the stated investment objectives of mutual funds adequately represent their attributes to investors. That is, if mutual funds adhere to their stated objectives, attributes must be heterogeneous between investment objective groups and homogeneous within them. Our conclusion is to some degree, the group of optimized exponential funds is heterogeneous to other groups. As a whole, there exist no significant differences between different objective groups; and 50% of mutual funds are not consistent with their objective groups.

  18. Connection-based and object-based grouping in multiple-object tracking: A developmental study

    OpenAIRE

    Hallen, Ruth; Reusens, J. (Julie); Evers, K. (Kris); de-Wit, Lee; Wagemans, Johan

    2018-01-01

    textabstractDevelopmental research on Gestalt laws has previously revealed that, even as young as infancy, we are bound to group visual elements into unitary structures in accordance with a variety of organizational principles. Here, we focus on the developmental trajectory of both connection-based and object-based grouping, and investigate their impact on object formation in participants, aged 9-21 years old (N = 113), using a multiple-object tracking paradigm. Results reveal a main effect o...

  19. Objectivity

    CERN Document Server

    Daston, Lorraine

    2010-01-01

    Objectivity has a history, and it is full of surprises. In Objectivity, Lorraine Daston and Peter Galison chart the emergence of objectivity in the mid-nineteenth-century sciences--and show how the concept differs from its alternatives, truth-to-nature and trained judgment. This is a story of lofty epistemic ideals fused with workaday practices in the making of scientific images. From the eighteenth through the early twenty-first centuries, the images that reveal the deepest commitments of the empirical sciences--from anatomy to crystallography--are those featured in scientific atlases, the compendia that teach practitioners what is worth looking at and how to look at it. Galison and Daston use atlas images to uncover a hidden history of scientific objectivity and its rivals. Whether an atlas maker idealizes an image to capture the essentials in the name of truth-to-nature or refuses to erase even the most incidental detail in the name of objectivity or highlights patterns in the name of trained judgment is a...

  20. Study of some physical aspects previous to design of an exponential experiment

    International Nuclear Information System (INIS)

    Caro, R.; Francisco, J. L. de

    1961-01-01

    This report presents the theoretical study of some physical aspects previous to the design of an exponential facility. The are: Fast and slow flux distribution in the multiplicative medium and in the thermal column, slowing down in the thermal column, geometrical distribution and minimum needed intensity of sources access channels and perturbations produced by possible variations in its position and intensity. (Author) 4 refs

  1. Object oriented distributed programming: studies and proposals

    International Nuclear Information System (INIS)

    Guerraoui, Rachid

    1992-01-01

    This thesis contributes to the investigation of the object concept in distributed programming. Henceforth, this programming style has become a reality in the computer science world, since it allows to increase of the availability of applications and to decrease their execution time. Nevertheless, designing a distributed application is a hard task: the various abstraction levels that must be considered hinder the software reusability and maintenance, while errors and concurrent accesses are often sources of executions incoherence. The object concept improves the software modularity, and raises the computing abstraction level. Integrating distribution related aspects into the object model brings up the issues of expressing the concurrency and maintaining the coherency. The investigation of these problems in this thesis has been guided by a major concern for the preservation of the intrinsic properties of object-orientation, and the orthogonality of the solutions given. The main contributions of the thesis are: (i) the classification, regarding modularity, of the different design alternatives for object-oriented concurrent languages; (ii) the evaluation of various transactional mechanisms in object-based concurrent languages, and the design of an atomic asynchronous communication protocol named ACS; (iii) the definition of a transaction-based object-oriented concurrent language called KAROS; (iv) the implementation of a modular framework which allows to combine in a same application, various concurrency control and error recovery mechanisms; (v) the identification of a formal property, named general atomicity, which constitutes a correctness criteria for atomic objects specifications. (author) [fr

  2. Study of functional-performance deficits in athletes with previous ankle sprains

    Directory of Open Access Journals (Sweden)

    hamid Babaee

    2008-04-01

    Full Text Available Abstract Background: Despite the importance of functional-performance deficits in athletes with history of ankle sprain few, studies have been carried out in this area. The aim of this research was to study relationship between previous ankle sprains and functional-performance deficits in athletes. Materials and methods: The subjects were 40 professional athletes selected through random sampling among volunteer participants in soccer, basketball, volleyball and handball teams of Lorestan province. The subjects were divided into 2 groups: Injured group (athletes with previous ankle sprains and healthy group (athletes without previous ankle sprains. In this descriptive study we used Functional-performance tests (figure 8 hop test and side hop test to determine ankle deficits and limitations. They participated in figure 8 hop test including hopping in 8 shape course with the length of 5 meters and side hop test including 10 side hop repetitions in course with the length of 30 centimeters. Time were recorded via stopwatch. Results: After data gathering and assessing information distributions, Pearson correlation was used to assess relationships, and independent T test to assess differences between variables. Finally the results showed that there is a significant relationship between previous ankle sprains and functional-performance deficits in the athletes. Conclusion: The athletes who had previous ankle sprains indicated functional-performance deficits more than healthy athletes in completion of mentioned functional-performance tests. The functional-performance tests (figure 8 hop test and side hop test are sensitive and suitable to assess and detect functional-performance deficits in athletes. Therefore we can use the figure 8 hop and side hop tests for goals such as prevention, assessment and rehabilitation of ankle sprains without spending too much money and time.

  3. Effect of Previous Irradiation on Vascular Thrombosis of Microsurgical Anastomosis: A Preclinical Study in Rats

    Science.gov (United States)

    Gallardo-Calero, Irene; López-Fernández, Alba; Romagosa, Cleofe; Vergés, Ramona; Aguirre-Canyadell, Marius; Soldado, Francisco; Velez, Roberto

    2016-01-01

    Background: The objective of the present investigation was to compare the effect of neoadjuvant irradiation on the microvascular anastomosis in cervical bundle using an experimental model in rats. Methods: One hundred forty male Sprague–Dawley rats were allocated into 4 groups: group I, control, arterial microanastomosis; group II, control, venous microanastomosis; group III, arterial microanastomosis with previous irradiation (20 Gy); and group IV, venous microanastomosis with previous irradiation (20 Gy). Clinical parameters, technical values of anastomosis, patency, and histopathological parameters were evaluated. Results: Irradiated groups (III and IV) and vein anastomosis groups (II and IV) showed significantly increased technical difficulties. Group IV showed significantly reduced patency rates (7/35) when compared with the control group (0/35). Radiotherapy significantly decreased the patency rates of the vein (7/35) when compared with the artery (1/35). Groups III and IV showed significantly reduced number of endothelial cells and also showed the presence of intimal thickening and adventitial fibrosis as compared with the control group. Conclusion: Neoadjuvant radiotherapy reduces the viability of the venous anastomosis in a preclinical rat model with a significant increase in the incidence of vein thrombosis. PMID:27975009

  4. Eye-tracking study of inanimate objects

    Directory of Open Access Journals (Sweden)

    Ković Vanja

    2009-01-01

    Full Text Available Unlike the animate objects, where participants were consistent in their looking patterns, for inanimates it was difficult to identify both consistent areas of fixations and a consistent order of fixations. Furthermore, in comparison to animate objects, in animates received significantly shorter total looking time, shorter longest looks and a smaller number of overall fixations. However, as with animates, looking patterns did not systematically differ between the naming and non-naming conditions. These results suggested that animacy, but not labelling, impacts on looking behavior in this paradigm. In the light of feature-based accounts of semantic memory organization, one could interpret these findings as suggesting that processing of the animate objects is based on the saliency/diagnosticity of their visual features (which is then reflected through participants eye-movements towards those features, whereas processing of the inanimate objects is based more on functional features (which cannot be easily captured by looking behavior in such a paradigm.

  5. Interbirth interval and history of previous preeclampsia: a case–control study among multiparous women

    OpenAIRE

    Harutyunyan, Arusyak; Armenian, Haroutune; Petrosyan, Varduhi

    2013-01-01

    Abstract Background Preeclampsia is a disorder with a reported incidence of 2%-8% among all pregnancies, accounting for more than 50,000 deaths worldwide each year. In low- and middle- income countries maternal/perinatal morbidity and mortality associated with preeclampsia are high due to the lack of proper prenatal and hospital care and limited access to neonatal intensive care. The objectives of our study were to determine the association of long in...

  6. Data from studies of previous radioactive waste disposal in Massachusetts Bay

    International Nuclear Information System (INIS)

    Curtis, W.R.; Mardis, H.M.

    1984-12-01

    This report presents the results of studies conducted in Massachusetts Bay during 1981 and 1982. Included are data from: (1) a side scan sonar survey of disposal areas in the Bay that was carried out by the National Oceanic and Atmospheric Administration (NOAA) for EPA; (2) Collections of sediment and biota by NOAA for radiochemical analysis by EPA; (3) collections of marketplace seafood samples by the Food and Drug Administration (FDA) for radioanalysis by both FDA and EPA; and (4) a radiological monitoring survey of LLW disposal areas by EPA to determine whether there should be any concern for public health resulting from previous LLW disposals in the Bay

  7. An ERP Study on Self-Relevant Object Recognition

    Science.gov (United States)

    Miyakoshi, Makoto; Nomura, Michio; Ohira, Hideki

    2007-01-01

    We performed an event-related potential study to investigate the self-relevance effect in object recognition. Three stimulus categories were prepared: SELF (participant's own objects), FAMILIAR (disposable and public objects, defined as objects with less-self-relevant familiarity), and UNFAMILIAR (others' objects). The participants' task was to…

  8. Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

    Directory of Open Access Journals (Sweden)

    Moreno Victor

    2011-08-01

    Full Text Available Abstract Background Colorectal cancer (CRC is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with several common low-penetrance alleles contributing to CRC genetic predisposition could be hypothesized. Mucins and GALNTs (N-acetylgalactosaminyltransferase are interesting candidates for CRC genetic susceptibility and have not been previously evaluated. We present results for ten genetic variants linked to CRC risk in previous studies (previously identified category and 18 selected variants from the mucin gene family in a case-control association study from the Spanish EPICOLON consortium. Methods CRC cases and matched controls were from EPICOLON, a prospective, multicenter, nationwide Spanish initiative, comprised of two independent stages. Stage 1 corresponded to 515 CRC cases and 515 controls, whereas stage 2 consisted of 901 CRC cases and 909 controls. Also, an independent cohort of 549 CRC cases and 599 controls outside EPICOLON was available for additional replication. Genotyping was performed for ten previously identified SNPs in ADH1C, APC, CCDN1, IL6, IL8, IRS1, MTHFR, PPARG, VDR and ARL11, and 18 selected variants in the mucin gene family. Results None of the 28 SNPs analyzed in our study was found to be associated with CRC risk. Although four SNPs were significant with a P-value ADH1C (OR = 1.63, 95% CI = 1.06-2.50, P-value = 0.02, recessive, rs1800795 in IL6 (OR = 1.62, 95% CI = 1.10-2.37, P-value = 0.01, recessive, rs3803185 in ARL11 (OR = 1.58, 95% CI = 1.17-2.15, P-value = 0.007, codominant, and rs2102302 in GALNTL2 (OR = 1.20, 95% CI = 1.00-1.44, P-value = 0.04, log-additive 0, 1, 2 alleles], only rs3803185 achieved statistical significance in EPICOLON stage 2 (OR = 1.34, 95% CI = 1.06-1.69, P-value = 0.01, recessive. In the joint analysis for both stages, results were only significant for rs3803185 (OR = 1

  9. Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

    International Nuclear Information System (INIS)

    Abulí, Anna; Morillas, Juan D; Rigau, Joaquim; Latorre, Mercedes; Fernández-Bañares, Fernando; Peña, Elena; Riestra, Sabino; Payá, Artemio; Jover, Rodrigo; Xicola, Rosa M; Llor, Xavier; Fernández-Rozadilla, Ceres; Carvajal-Carmona, Luis; Villanueva, Cristina M; Moreno, Victor; Piqué, Josep M; Carracedo, Angel; Castells, Antoni; Andreu, Montserrat; Ruiz-Ponte, Clara; Castellví-Bel, Sergi; Alonso-Espinaco, Virginia; Muñoz, Jenifer; Gonzalo, Victoria; Bessa, Xavier; González, Dolors; Clofent, Joan; Cubiella, Joaquin

    2011-01-01

    Colorectal cancer (CRC) is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with several common low-penetrance alleles contributing to CRC genetic predisposition could be hypothesized. Mucins and GALNTs (N-acetylgalactosaminyltransferase) are interesting candidates for CRC genetic susceptibility and have not been previously evaluated. We present results for ten genetic variants linked to CRC risk in previous studies (previously identified category) and 18 selected variants from the mucin gene family in a case-control association study from the Spanish EPICOLON consortium. CRC cases and matched controls were from EPICOLON, a prospective, multicenter, nationwide Spanish initiative, comprised of two independent stages. Stage 1 corresponded to 515 CRC cases and 515 controls, whereas stage 2 consisted of 901 CRC cases and 909 controls. Also, an independent cohort of 549 CRC cases and 599 controls outside EPICOLON was available for additional replication. Genotyping was performed for ten previously identified SNPs in ADH1C, APC, CCDN1, IL6, IL8, IRS1, MTHFR, PPARG, VDR and ARL11, and 18 selected variants in the mucin gene family. None of the 28 SNPs analyzed in our study was found to be associated with CRC risk. Although four SNPs were significant with a P-value < 0.05 in EPICOLON stage 1 [rs698 in ADH1C (OR = 1.63, 95% CI = 1.06-2.50, P-value = 0.02, recessive), rs1800795 in IL6 (OR = 1.62, 95% CI = 1.10-2.37, P-value = 0.01, recessive), rs3803185 in ARL11 (OR = 1.58, 95% CI = 1.17-2.15, P-value = 0.007, codominant), and rs2102302 in GALNTL2 (OR = 1.20, 95% CI = 1.00-1.44, P-value = 0.04, log-additive 0, 1, 2 alleles], only rs3803185 achieved statistical significance in EPICOLON stage 2 (OR = 1.34, 95% CI = 1.06-1.69, P-value = 0.01, recessive). In the joint analysis for both stages, results were only significant for rs3803185 (OR = 1.12, 95% CI = 1

  10. A Comparative Investigation of the Previous and New Secondary History Curriculum: The Issues of the Definition of the Aims and Objectives and the Selection of Curriculum Content

    Science.gov (United States)

    Dinc, Erkan

    2011-01-01

    Discussions on history teaching in Turkey indicate that the previous versions of the history curriculum and the pedagogy of history in the country bear many problems and deficiencies. The problems of Turkish history curriculum mainly arise from the perspectives it takes and the selection of its content. Since 2003, there have been extensive…

  11. A study about the interest and previous contact of high school students with Astronomy

    Science.gov (United States)

    Carvalho, C. L.; Zanitti, M. H. R.; Felicidade, B. L.; Gomes, A. D. T.; Dias, E. W.; Coelho, F. O.

    2016-04-01

    The currently problems in Astronomy teaching in Brazilian Basic Education contrast with the space, and the popularity that astronomical themes have in various media in the country. In this work, we present the results of a study about the interest, and previous contact of high school students from a public school in the city of "São João del-Rei"/MG with topics related to Astronomy. The study and the pedagogical intervention were carried out by students of the PIBID/CAPES/UFSJ. The intervention was performed through an oral exposition with the students' participation, followed by the use of the Stellarium program. The results suggest the majority of students surveyed are interested in Astronomy, and have had some contact with the area. However, some inconsistencies in their responses were identified and examined. The implications for research and for Astronomy Education are discussed. We also make some considerations about relationship between the lack of specific knowledge and the misinformation as one possible reason for the little interest of students in various areas of Science.

  12. Creating Objects and Object Categories for Studying Perception and Perceptual Learning

    Science.gov (United States)

    Hauffen, Karin; Bart, Eugene; Brady, Mark; Kersten, Daniel; Hegdé, Jay

    2012-01-01

    In order to quantitatively study object perception, be it perception by biological systems or by machines, one needs to create objects and object categories with precisely definable, preferably naturalistic, properties1. Furthermore, for studies on perceptual learning, it is useful to create novel objects and object categories (or object classes) with such properties2. Many innovative and useful methods currently exist for creating novel objects and object categories3-6 (also see refs. 7,8). However, generally speaking, the existing methods have three broad types of shortcomings. First, shape variations are generally imposed by the experimenter5,9,10, and may therefore be different from the variability in natural categories, and optimized for a particular recognition algorithm. It would be desirable to have the variations arise independently of the externally imposed constraints. Second, the existing methods have difficulty capturing the shape complexity of natural objects11-13. If the goal is to study natural object perception, it is desirable for objects and object categories to be naturalistic, so as to avoid possible confounds and special cases. Third, it is generally hard to quantitatively measure the available information in the stimuli created by conventional methods. It would be desirable to create objects and object categories where the available information can be precisely measured and, where necessary, systematically manipulated (or 'tuned'). This allows one to formulate the underlying object recognition tasks in quantitative terms. Here we describe a set of algorithms, or methods, that meet all three of the above criteria. Virtual morphogenesis (VM) creates novel, naturalistic virtual 3-D objects called 'digital embryos' by simulating the biological process of embryogenesis14. Virtual phylogenesis (VP) creates novel, naturalistic object categories by simulating the evolutionary process of natural selection9,12,13. Objects and object categories created

  13. The biomechanics of running in athletes with previous hamstring injury: A case-control study.

    Science.gov (United States)

    Daly, C; Persson, U McCarthy; Twycross-Lewis, R; Woledge, R C; Morrissey, D

    2016-04-01

    Hamstring injury is prevalent with persistently high reinjury rates. We aim to inform hamstring rehabilitation by exploring the electromyographic and kinematic characteristics of running in athletes with previous hamstring injury. Nine elite male Gaelic games athletes who had returned to sport after hamstring injury and eight closely matched controls sprinted while lower limb kinematics and muscle activity of the previously injured biceps femoris, bilateral gluteus maximus, lumbar erector spinae, rectus femoris, and external oblique were recorded. Intergroup comparisons of muscle activation ratios and kinematics were performed. Previously injured athletes demonstrated significantly reduced biceps femoris muscle activation ratios with respect to ipsilateral gluteus maximus (maximum difference -12.5%, P = 0.03), ipsilateral erector spinae (maximum difference -12.5%, P = 0.01), ipsilateral external oblique (maximum difference -23%, P = 0.01), and contralateral rectus femoris (maximum difference -22%, P = 0.02) in the late swing phase. We also detected sagittal asymmetry in hip flexion (maximum 8°, P = 0.01), pelvic tilt (maximum 4°, P = 0.02), and medial rotation of the knee (maximum 6°, P = 0.03) effectively putting the hamstrings in a lengthened position just before heel strike. Previous hamstring injury is associated with altered biceps femoris associated muscle activity and potentially injurious kinematics. These deficits should be considered and addressed during rehabilitation. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  14. Rancidity inhibition study in frozen whole mackerel (scomber scombrus by a previous plant extract treatment.

    Directory of Open Access Journals (Sweden)

    Aubourg, Santiago P.

    2005-09-01

    Full Text Available The effect of flaxseeds (Linum usitatissimum on rancidity development in frozen whole mackerel (Scomber scombrus was studied. For it, fresh mackerel were dipped in flaxseeds aqueous extract during 60 min, frozen at –80 ºC during 24 hours and kept frozen (–20 ºC up to 12 months. Sampling was carried out on the initial material and at months 1, 3, 5, 7, 9 and 12 of frozen storage at –20 ºC. A parallel experiment with non treated fish was carried out in the same conditions. Rancidity development was measured by several biochemical indices (free fatty acids, peroxides, conjugated dienes and trienes, secondary oxidation products and lipoxygenase activity and complemented by the sensory analysis (skin, flesh odour, consistency and flesh appearance. As a result of the previous antioxidant treatment, peroxides showed to breakdown faster (pSe ha estudiado el efecto del lino (Linum usitatissimum en el desarrollo de rancidez en caballa entera congelada (Scomber scombrus. Para ello, caballas frescas fueron sumergidas en extractos acuosos de semillas de lino durante 60 min, congeladas a -80 ºC durante 24 h y mantenidas congeladas ( -20 ºC durante 12 meses. Se tomaron muestras del material inicial y tras 1, 3, 5, 7, 9 y 12 meses de congelación a -20 ºC . Un experimento paralelo con pescado no tratado fue llevado acabo en las mismas condiciones. El desarrollo de la rancidez fue medido por varios índices bioquímicos (ácidos grasos libres, peróxidos, dienos y trienos conjugados, productos secundarios de oxidación y actividad lipoxigenasa y completado con análisis sensorial (piel, olor de la carne, consistencia y apariencia de la carne. Como resultado del tratamiento antioxidante, los peróxidos se degradaron más rápidos (p < 0.05 después del mes 7, y por tanto, contenidos mayores (p < 0.05 de dienos y trienos conjugados pudieron ser detectados en el pescado tratado. El tratamiento antioxidante también condujo a un

  15. Object based implicit contextual learning: a study of eye movements.

    Science.gov (United States)

    van Asselen, Marieke; Sampaio, Joana; Pina, Ana; Castelo-Branco, Miguel

    2011-02-01

    Implicit contextual cueing refers to a top-down mechanism in which visual search is facilitated by learned contextual features. In the current study we aimed to investigate the mechanism underlying implicit contextual learning using object information as a contextual cue. Therefore, we measured eye movements during an object-based contextual cueing task. We demonstrated that visual search is facilitated by repeated object information and that this reduction in response times is associated with shorter fixation durations. This indicates that by memorizing associations between objects in our environment we can recognize objects faster, thereby facilitating visual search.

  16. Late preterm birth and previous cesarean section: a population-based cohort study.

    Science.gov (United States)

    Yasseen Iii, Abdool S; Bassil, Kate; Sprague, Ann; Urquia, Marcelo; Maguire, Jonathon L

    2018-02-21

    Late preterm birth (LPB) is increasingly common and associated with higher morbidity and mortality than term birth. Yet, little is known about the influence of previous cesarean section (PCS) and the occurrence of LPB in subsequent pregnancies. We aim to evaluate this association along with the potential mediation by cesarean sections in the current pregnancy. We use population-based birth registry data (2005-2012) to establish a cohort of live born singleton infants born between 34 and 41 gestational weeks to multiparous mothers. PCS was the primary exposure, LPB (34-36 weeks) was the primary outcome, and an unplanned or emergency cesarean section in the current pregnancy was the potential mediator. Associations were quantified using propensity weighted multivariable Poisson regression, and mediating associations were explored using the Baron-Kenny approach. The cohort included 481,531 births, 21,893 (4.5%) were LPB, and 119,983 (24.9%) were predated by at least one PCS. Among mothers with at least one PCS, 6307 (5.26%) were LPB. There was increased risk of LPB among women with at least one PCS (adjusted Relative Risk (aRR): 1.20 (95%CI [1.16, 1.23]). Unplanned or emergency cesarean section in the current pregnancy was identified as a strong mediator to this relationship (mediation ratio = 97%). PCS was associated with higher risk of LPB in subsequent pregnancies. This may be due to an increased risk of subsequent unplanned or emergency preterm cesarean sections. Efforts to minimize index cesarean sections may reduce the risk of LPB in subsequent pregnancies.

  17. Treatment satisfaction with paliperidone extended-release tablets: open-label study in schizophrenia patients dissatisfied with previous antipsychotic medication

    Directory of Open Access Journals (Sweden)

    Yang FD

    2017-04-01

    Full Text Available Fu De Yang,1 Juan Li,1 Yun Long Tan,1 Wei Ye Liang,1 Rongzhen Zhang,1 Ning Wang,1 Wei Feng,1 Shangli Cai,2 Jian Min Zhuo,2 Li Li Zhang2 1Beijing Hui-Long-Guan Hospital, 2Department of Medical Affairs, Xian Janssen Pharmaceutical Ltd, Beijing, People’s Republic of China Objective: The aim of this study was to evaluate the changes in treatment satisfaction after switching to paliperidone extended-release (ER in Chinese schizophrenia patients dissatisfied with their previous antipsychotic treatment.Methods: In this 8-week, open-label, single-arm, multicenter, prospective study, 1,693 patients dissatisfied with previous antipsychotic medication were enrolled and switched to paliperidone ER tablets (3–12 mg/d based on clinical judgment. The primary efficacy end point was change in Medication Satisfaction Questionnaire (MSQ score from baseline to week 8. The secondary end points included percentage of patients with MSQ score ≥4, as well as changes in Clinical Global Improvement-Severity (CGI-S and Personal and Social Performance (PSP scores.Results: MSQ scores increased significantly from baseline (mean [standard deviation {SD}]: 2.48 [0.55] to week 8 (5.47 [0.89], P<0.0001; primary end point, full analysis set. The percentage of patients with MSQ score ≥4 was 95.9% at week 8, indicating that most of the patients were satisfied with their treatment. Significant (P<0.0001 improvements from baseline to week 8 were noted in CGI-S score (2.37 [1.20] and PSP score (25.5 [15.0]. A total of 174 (10.28% patients experienced adverse events (AEs. The most common (>10 patients events were extrapyramidal disorder (n=84, 4.96%, poor quality sleep (n=18, 1.06% and akathisia (n=13, 0.77%. The majority of AEs were mild to moderate in severity. No deaths occurred.Conclusion: Treatment satisfaction improved after switching to paliperidone ER from the previous antipsychotic in Chinese patients with schizophrenia. Keywords: atypical antipsychotics, open label

  18. Phase III Study of Cabozantinib in Previously Treated Metastatic Castration-Resistant Prostate Cancer: COMET-1.

    Science.gov (United States)

    Smith, Matthew; De Bono, Johann; Sternberg, Cora; Le Moulec, Sylvestre; Oudard, Stéphane; De Giorgi, Ugo; Krainer, Michael; Bergman, Andries; Hoelzer, Wolfgang; De Wit, Ronald; Bögemann, Martin; Saad, Fred; Cruciani, Giorgio; Thiery-Vuillemin, Antoine; Feyerabend, Susan; Miller, Kurt; Houédé, Nadine; Hussain, Syed; Lam, Elaine; Polikoff, Jonathan; Stenzl, Arnulf; Mainwaring, Paul; Ramies, David; Hessel, Colin; Weitzman, Aaron; Fizazi, Karim

    2016-09-01

    Cabozantinib is an inhibitor of kinases, including MET and vascular endothelial growth factor receptors, and has shown activity in men with previously treated metastatic castration-resistant prostate cancer (mCRPC). This blinded phase III trial compared cabozantinib with prednisone in patients with mCRPC. Men with progressive mCRPC after docetaxel and abiraterone and/or enzalutamide were randomly assigned at a two-to-one ratio to cabozantinib 60 mg once per day or prednisone 5 mg twice per day. The primary end point was overall survival (OS). Bone scan response (BSR) at week 12 as assessed by independent review committee was the secondary end point; radiographic progression-free survival (rPFS) and effects on circulating tumor cells (CTCs), bone biomarkers, serum prostate-specific antigen (PSA), and symptomatic skeletal events (SSEs) were exploratory assessments. A total of 1,028 patients were randomly assigned to cabozantinib (n = 682) or prednisone (n = 346). Median OS was 11.0 months with cabozantinib and 9.8 months with prednisone (hazard ratio, 0.90; 95% CI, 0.76 to 1.06; stratified log-rank P = .213). BSR at week 12 favored cabozantinib (42% v 3%; stratified Cochran-Mantel-Haenszel P < .001). rPFS was improved in the cabozantinib group (median, 5.6 v 2.8 months; hazard ratio, 0.48; 95% CI, 0.40 to 0.57; stratified log-rank P < .001). Cabozantinib was associated with improvements in CTC conversion, bone biomarkers, and post-random assignment incidence of SSEs but not PSA outcomes. Grade 3 to 4 adverse events and discontinuations because of adverse events were higher with cabozantinib than with prednisone (71% v 56% and 33% v 12%, respectively). Cabozantinib did not significantly improve OS compared with prednisone in heavily treated patients with mCRPC and progressive disease after docetaxel and abiraterone and/or enzalutamide. Cabozantinib had some activity in improving BSR, rPFS, SSEs, CTC conversions, and bone biomarkers but not PSA outcomes. © 2016 by

  19. Subjective experience of architectural objects: A cross-cultural study

    Directory of Open Access Journals (Sweden)

    Marković Slobodan

    2016-01-01

    Full Text Available The purpose of the present study was to compare Serbian and Japanese participants in their subjective experience of Serbian and Japanese architectural objects. Subjective experience was operationalized through the ratings on the bipolar scales (e.g. pleasant-unpleasant. In the Preliminary study 1, a set of twelve rating scales was generated. In the Preliminary study 2 twelve Serbian and twelve Japanese architectural objects were specified. In the main experiment two groups of participants, twenty-one Serbian and twenty Japanese, rated twelve Serbian and twelve Japanese objects. A factor analysis extracted three dimensions of subjective experience: Beauty, Firmness and Fullness. Analysis of variance have shown that both Serbian and Japanese participants agreed that Japanese architectural objects looked more beautiful and firmer than Serbian objects. These finding is generally in line with perceptualist hypothesis that stimulus constraints are more effective than culture. However, interactions revealed some cultural differences that are consistent with culturalist hypothesis: compared to Serbian participants, Japanese participants rated Japanese architectural objects as more beautiful, whereas, compared to Japanese, Serbian participants rated Serbian objects as less fragile and emptier than Japanese objects. Generaly, our study have shown that Serbian (Western and Japanese (Eastern participants show general similarity in their subjective experience of architectural objects. [Projekat Ministarstva nauke Republike Srbije, br. 179033

  20. Radon diffusion coefficients for soils. Previous studies and their application to uranium-bearing wastes

    International Nuclear Information System (INIS)

    Sasaki, Tomozo; Gunji, Yasuyoshi; Iida, Takao

    2008-01-01

    Radon diffusion in soils has been studied over the years by many researchers. The application of such studies to the evaluation of radiation exposure caused by radon from uranium-bearing wastes disposed in a shallow land site is very important. The present paper surveyed closely relevant studies and elucidated the inherent nature of radon diffusion in terms of the definition of radon diffusion coefficients. Then, basic features of measurement methods for determining radon diffusion coefficients in soils were explained. Furthermore, theoretical aspects of radon diffusion in soils were discussed in terms of microscopic radon diffusion in soils and large-scale radon diffusion through cover soil defects for uranium mill tailings. Finally, in order to apply the radon diffusion studies to uranium-bearing waste disposal in shallow land sites, new challenges were presented: elucidation of radon diffusion in uranium-bearing wastes and cover-soil cracks, and demonstration of the validity of applying only radon diffusion in the evaluation of radiation exposure caused by radon, which would come through Japanese cover soils for uranium-bearing waste disposal. (author)

  1. A Review of Previous Studies on Information Processing in Career Decision Making among University Students

    OpenAIRE

    池田, 智子; Satoko, Ikeda

    2018-01-01

    This review of the researches of career choice of Japanese university students focused the studies on decision-making theory conducted in Japan. The present review suggested the necessity of examination of the effect of self-efficacy about career information search on the process of career choice. It is also needed to examine the relationship between specific self-efficacy about career information search and career decision-making self-efficacy, moreover, general self-efficacy.

  2. A Comment Upon Previous Studies on 3-D Boundary Layer Transition

    OpenAIRE

    ÇARPINLIOĞLU, Melda Özdinç

    2014-01-01

    The common feature of the experimental studies upon 3-D boundary layer development on swept flat plates cited in the available literature is the application of streamwise and/or spanwise pressure gradients. In fact; presence of the pressure gradients was suggested to be vital for having crossflow effective in 3-D boundary layer transition. In the presented paper here, this idea is questioned evaluating the results of an experimental investigation conducted on swept flat plates under the ab...

  3. Neuropsychiatric and cardiometabolic comorbidities in patients with previously diagnosed Cushing's disease: a longitudinal observational study

    OpenAIRE

    Dimopoulou, C; Geraedts, V; Stalla, G K; Sievers, C

    2015-01-01

    INTRODUCTION: Only few studies have systematically investigated neuropsychiatric aspects in patients with Cushing's disease (CD). Pain syndromes have been described in patients with pituitary adenomas, but so far no systematical investigation has been conducted in patients with CD. Additionally, CD has an association with cardiometabolic comorbidities which ultimately leads to increased morbidity and mortality. Long-term treatment of the hypercortisolic state cannot prevent the persistence of...

  4. A New Zealand based cohort study of anaesthetic trainees' career outcomes compared with previously expressed intentions.

    Science.gov (United States)

    Moran, E M L; French, R A; Kennedy, R R

    2011-09-01

    Predicting workforce requirements is a difficult but necessary part of health resource planning. A 'snapshot' workforce survey undertaken in 2002 examined issues that New Zealand anaesthesia trainees expected would influence their choice of future workplace. We have restudied the same cohort to see if that workforce survey was a good predictor of outcome. Seventy (51%) of 138 surveys were completed in 2009 compared with 100 (80%) of 138 in the 2002 survey. Eighty percent of the 2002 respondents planned consultant positions in New Zealand. We found 64% of respondents were working in New Zealand (P New Zealand based respondents but only 40% of those living outside New Zealand agreed or strongly agreed with this statement (P New Zealand but was important for only 2% of those resident in New Zealand (P New Zealand were predominantly between NZ$150,000 and $200,000 while those overseas received between NZ$300,000 and $400,000. Of those that are resident in New Zealand, 84% had studied in a New Zealand medical school compared with 52% of those currently working overseas (P < 0.01). Our study shows that stated career intentions in a group do not predict the actual group outcomes. We suggest that 'snapshot' studies examining workforce intentions are of little value for workforce planning. However we believe an ongoing program matching career aspirations against career outcomes would be a useful tool in workforce planning.

  5. Life cycle impact assessment of ammonia production in Algeria: A comparison with previous studies

    Energy Technology Data Exchange (ETDEWEB)

    Makhlouf, Ali, E-mail: almakhsme@gmail.com; Serradj, Tayeb; Cheniti, Hamza

    2015-01-15

    In this paper, a Life Cycle Analysis (LCA) from “cradle to gate” of one anhydrous ton of ammonia with a purity of 99% was achieved. Particularly, the energy and environmental performance of the product (ammonia) were evaluated. The eco-profile of the product and the share of each stage of the Life Cycle on the whole environmental impacts have been evaluated. The flows of material and energy for each phase of the life cycle were counted and the associated environmental problems were identified. Evaluation of the impact was achieved using GEMIS 4.7 software. The primary data collection was executed at the production installations located in Algeria (Annaba locality). The analysis was conducted according to the LCA standards ISO 14040 series. The results show that Cumulative Energy Requirement (CER) is of 51.945 × 10{sup 3} MJ/t of ammonia, which is higher than the global average. Global Warming Potential (GWP) is of 1.44 t CO{sub 2} eq/t of ammonia; this value is lower than the world average. Tropospheric ozone precursor and Acidification are also studied in this article, their values are: 549.3 × 10{sup −6} t NMVOC eq and 259.3 × 10{sup −6} t SO{sub 2} eq respectively.

  6. Life cycle impact assessment of ammonia production in Algeria: A comparison with previous studies

    International Nuclear Information System (INIS)

    Makhlouf, Ali; Serradj, Tayeb; Cheniti, Hamza

    2015-01-01

    In this paper, a Life Cycle Analysis (LCA) from “cradle to gate” of one anhydrous ton of ammonia with a purity of 99% was achieved. Particularly, the energy and environmental performance of the product (ammonia) were evaluated. The eco-profile of the product and the share of each stage of the Life Cycle on the whole environmental impacts have been evaluated. The flows of material and energy for each phase of the life cycle were counted and the associated environmental problems were identified. Evaluation of the impact was achieved using GEMIS 4.7 software. The primary data collection was executed at the production installations located in Algeria (Annaba locality). The analysis was conducted according to the LCA standards ISO 14040 series. The results show that Cumulative Energy Requirement (CER) is of 51.945 × 10 3 MJ/t of ammonia, which is higher than the global average. Global Warming Potential (GWP) is of 1.44 t CO 2 eq/t of ammonia; this value is lower than the world average. Tropospheric ozone precursor and Acidification are also studied in this article, their values are: 549.3 × 10 −6 t NMVOC eq and 259.3 × 10 −6 t SO 2 eq respectively

  7. Effect of object functions on tomographic reconstruction a numerical study

    International Nuclear Information System (INIS)

    Babu Rao, C.; Baldev Raj; Ravichandran, V.S.; Munshi, P.

    1996-01-01

    Convolution back projection is the most widely used algorithm of computed tomography (CT). Theoretical studies show that under ideal conditions, the error in the reconstruction can be correlated with the second fourier space derivative of filter function and with the Laplacian of the object function. This paper looks into the second aspect of the error function. In this paper a systematic numerical study is presented on the effect to object functions on global and local errors. (author)

  8. Sunburn and sun-protective behaviors among adults with and without previous nonmelanoma skin cancer: a population-based study

    Science.gov (United States)

    Fischer, Alexander H.; Wang, Timothy S.; Yenokyan, Gayane; Kang, Sewon; Chien, Anna L.

    2016-01-01

    Background Individuals with previous nonmelanoma skin cancer (NMSC) are at increased risk for subsequent skin cancer, and should therefore limit UV exposure. Objective To determine whether individuals with previous NMSC engage in better sun protection than those with no skin cancer history. Methods We pooled self-reported data (2005 and 2010 National Health Interview Surveys) from US non-Hispanic white adults (758 with and 34,161 without previous NMSC). We calculated adjusted prevalence odds ratios (aPOR) and 95% confidence intervals (95% CI), taking into account the complex survey design. Results Individuals with previous NMSC versus no history of NMSC had higher rates of frequent use of shade (44.3% versus 27.0%; aPOR=1.41; 1.16–1.71), long sleeves (20.5% versus 7.7%; aPOR=1.55; 1.21–1.98), a wide-brimmed hat (26.1% versus 10.5%; aPOR=1.52; 1.24–1.87), and sunscreen (53.7% versus 33.1%; aPOR=2.11; 95% CI=1.73–2.59), but did not have significantly lower odds of recent sunburn (29.7% versus 40.7%; aPOR=0.95; 0.77–1.17). Among subjects with previous NMSC, recent sunburn was inversely associated with age, sun avoidance, and shade but not sunscreen. Limitations Self-reported cross-sectional data and unavailable information quantifying regular sun exposure. Conclusion Physicians should emphasize sunburn prevention when counseling patients with previous NMSC, especially younger adults, focusing on shade and sun avoidance over sunscreen. PMID:27198078

  9. Ifosfamide in previously untreated disseminated neuroblastoma. Results of Study 3A of the European Neuroblastoma Study Group.

    Science.gov (United States)

    Kellie, S J; De Kraker, J; Lilleyman, J S; Bowman, A; Pritchard, J

    1988-05-01

    A prospective study of the effectiveness of ifosfamide as a single agent in the management of previously untreated patients with Evans stage IV neuroblastoma was undertaken. Eighteen children aged more than 1 year were treated with ifosfamide (IFX) 3 g/m2 daily for 2 days immediately after diagnosis and 3 weeks later. Treatment was continued with combination chemotherapy using vincristine, cyclophosphamide, cisplatinum and etoposide (OPEC) or a variant. Mesna (2-mercaptoethane sulphonate) was given to all patients during IFX treatment to prevent urotoxicity. Eight of the 18 patients (44%) responded to IFX. Nine had greater than 66% reduction in baseline tumor volume. Of 15 evaluable patients with raised pre-treatment urinary catecholamine excretion, six (40%) achieved greater than 50% reduction in pretreatment levels. Two of 10 patients evaluable for bone marrow response had complete clearance. Toxicity was mild in all patients. Upon completing 'first line' therapy, only four patients (22%) achieved a good partial remission (GPR) or complete response (CR). Median survival was 11 months. There was a lower rate of attaining GPR and shortened median survival in patients receiving phase II IFX before OPEC or variant, compared to patients with similar pre-treatment characteristics treated with OPEC from diagnosis in an earlier study.

  10. Attachment to Inanimate Objects and Early Childcare: A Twin Study

    Directory of Open Access Journals (Sweden)

    Keren eFortuna

    2014-05-01

    Full Text Available Extensive nonmaternal childcare plays an important role in children's development. This study examined a potential coping mechanism for dealing with daily separation from caregivers involved in childcare experience—children's development of attachments toward inanimate objects. We employed the twin design to estimate relative environmental and genetic contributions to the presence of object attachment, and assess whether childcare explains some of the environmental variation in this developmental phenomenon. Mothers reported about 1122 3-year-old twin pairs. Variation in object attachment was accounted for by heritability (48% and shared environment (48%, with childcare quantity accounting for 2.2% of the shared environment effect. Children who spent half-days in childcare were significantly less likely to attach to objects relative to children who attended full-day childcare.

  11. Estimating the effect of current, previous and never use of drugs in studies based on prescription registries

    DEFF Research Database (Denmark)

    Nielsen, Lars Hougaard; Løkkegaard, Ellen; Andreasen, Anne Helms

    2009-01-01

    of this misclassification for analysing the risk of breast cancer. MATERIALS AND METHODS: Prescription data were obtained from Danish Registry of Medicinal Products Statistics and we applied various methods to approximate treatment episodes. We analysed the duration of HT episodes to study the ability to identify......PURPOSE: Many studies which investigate the effect of drugs categorize the exposure variable into never, current, and previous use of the study drug. When prescription registries are used to make this categorization, the exposure variable possibly gets misclassified since the registries do...... not carry any information on the time of discontinuation of treatment.In this study, we investigated the amount of misclassification of exposure (never, current, previous use) to hormone therapy (HT) when the exposure variable was based on prescription data. Furthermore, we evaluated the significance...

  12. An fMRI study of neuronal activation in schizophrenia patients with and without previous cannabis use

    Directory of Open Access Journals (Sweden)

    Else-Marie eLøberg

    2012-10-01

    Full Text Available Previous studies have mostly shown positive effects of cannabis use on cognition in patients with schizophrenia, which could reflect lower neurocognitive vulnerability. There are however no studies comparing whether such cognitive differences have neuronal correlates. Thus, the aim of the present study was to compare whether patients with previous cannabis use differ in brain activation from patients who has never used cannabis. The patients groups were compared on the ability to up-regulate an effort mode network during a cognitive task and down-regulate activation in the same network during a task-absent condition. Task-present and task-absent brain activation was measured by functional magnetic resonance neuroimaging (fMRI. Twenty-six patients with a DSM-IV and ICD-10 diagnosis of schizophrenia were grouped into a previous cannabis user group and a no-cannabis group. An auditory dichotic listening task with instructions of attention focus on either the right or left ear stimulus was used to tap verbal processing, attention and cognitive control, calculated as an aggregate score. When comparing the two groups, there were remaining activations in the task-present condition for the cannabis group, not seen in the no-cannabis group, while there was remaining activation in the task-absent condition for the no-cannabis group, not seen in the cannabis group. Thus, the patients with previous cannabis use showed increased activation in an effort mode network and decreased activation in the default mode network as compared to the no-cannabis group. It is concluded that the present study show some differences in brain activation to a cognitively challenging task between previous cannabis and no-cannabis schizophrenia patients.

  13. Website history and the website as an object of study

    DEFF Research Database (Denmark)

    Brügger, Niels

    2009-01-01

    This article puts on the agenda one of the fundamental theoretical questions within the emerging field of website history: how can the object of historical study — the website — be delimited? Its focus is on the 'website' artefact as a medium and a text. After elaborating a definition...

  14. Objectives of Financial Statements. Report of the Study Group on the Objectives of Financial Statements.

    Science.gov (United States)

    American Inst. of Certified Public Accountants, New York, NY.

    This report discusses the objectives of financial statements. Emphasis is placed on the function of objectives; users, their goals, and their information needs; the primary enterprise goal and earning power; accountability and financial statements; financial statements--reporting on the goal attainment of business enterprises; financial…

  15. Planning and setting objectives in field studies: Chapter 2

    Science.gov (United States)

    Fisher, Robert N.; Dodd, C. Kenneth

    2016-01-01

    This chapter enumerates the steps required in designing and planning field studies on the ecology and conservation of reptiles, as these involve a high level of uncertainty and risk. To this end, the chapter differentiates between goals (descriptions of what one intends to accomplish) and objectives (the measurable steps required to achieve the established goals). Thus, meeting a specific goal may require many objectives. It may not be possible to define some of them until certain experiments have been conducted; often evaluations of sampling protocols are needed to increase certainty in the biological results. And if sampling locations are fixed and sampling events are repeated over time, then both study-specific covariates and sampling-specific covariates should exist. Additionally, other critical design considerations for field study include obtaining permits, as well as researching ethics and biosecurity issues.

  16. Non-invasive studies of objects from cultural heritage

    International Nuclear Information System (INIS)

    Lehmann, Eberhard H.; Vontobel, Peter; Deschler-Erb, Eckhard; Soares, Marie

    2005-01-01

    In order to preserve the objects from European cultural heritage in its structure and shape for our future generations, there is a need to perform all investigations on important samples non-destructively or with very limited amounts of material. Among the non-destructive testing (NDT) methods available for this purpose there are those that need large installations such as accelerators and reactors to provide different kinds of radiation (X-ray, protons, neutrons, gamma, etc.). Therefore, a link between the specialists working at such facilities with scientists from museums and archaeological institutes is necessary. This paper describes the status of a European network dedicated to the NDT of museum objects (COST-G8) as an overview. In more detail, the activities in Switzerland will be presented where PSI plays a role for the study with neutrons and X-rays. Most of the investigated samples of Swiss collections are from Celtic or Roman origin. The superposition of both applied methods gives the opportunity to decide about the structure of objects and artefacts from restoration work applied later to the virgin excavation status. The presented examples will give an overview about opportunities of the applied methods and their limitations in some cases. This should be motivating to adapt the demonstrated methods to other similar objects of historical relevance

  17. The Netherlands XTC Toxicity (NeXT) study: objectives and methods of a study investigating causality, course, and clinical relevance

    NARCIS (Netherlands)

    de Win, Maartje M. L.; Jager, Gerry; Vervaeke, Hylke K. E.; Schilt, Thelma; Reneman, Liesbeth; Booij, Jan; Verhulst, Frank C.; den Heeten, Gerard J.; Ramsey, Nick F.; Korf, Dirk J.; van den Brink, Wim

    2005-01-01

    This paper describes the objectives and methods of The Netherlands XTC Toxicity (NeXT) study focussing on the causality, course, and clinical relevance of ecstasy neurotoxicity. Previous studies suggest that ecstasy (3,4 methylene-dioxymethamphetamine, MDMA, XTC) is toxic toward brain serotonin

  18. Dexamethasone intravitreal implant in previously treated patients with diabetic macular edema : Subgroup analysis of the MEAD study

    OpenAIRE

    Augustin, A.J.; Kuppermann, B.D.; Lanzetta, P.; Loewenstein, A.; Li, X.; Cui, H.; Hashad, Y.; Whitcup, S.M.; Abujamra, S.; Acton, J.; Ali, F.; Antoszyk, A.; Awh, C.C.; Barak, A.; Bartz-Schmidt, K.U.

    2015-01-01

    Background Dexamethasone intravitreal implant 0.7?mg (DEX 0.7) was approved for treatment of diabetic macular edema (DME) after demonstration of its efficacy and safety in the MEAD registration trials. We performed subgroup analysis of MEAD study results to evaluate the efficacy and safety of DEX 0.7 treatment in patients with previously treated DME. Methods Three-year, randomized, sham-controlled phase 3 study in patients with DME, best-corrected visual acuity (BCVA) of 34?68 Early Treatment...

  19. Radioimmunotherapy with Y-90-epratuzumab in patients with previously treated B-cell lymphoma. A fractionated dose-escalation study

    International Nuclear Information System (INIS)

    Linden, O.; Cavallin-Stahl, E.; Tennvall, J.; Hindorf, C.; Olsson, T.; Strand, S.E.; Stenberg, L.; Wingardh, K.

    2002-01-01

    Aim: Fractionated RIT may improve outcome by decreasing heterogeneity in absorbed dose and by increasing therapeutic window. The humanised anti-CD22 antibody, Epratuzumab, (Immunomedics, Inc., Morris Plains, NJ) can be given repeatedly with minimal risk of neutralising Ab (HAHA), making fractionated treatment with 90 Y-labelled epratuzumab possible. Materials and Methods: Patients with previously treated B-cell lymphoma received increasing number (2-4) of weekly infusions of 90 Y-epratuzumab. Patients received either 185 MBq/m 2 per infusion (group A), or, if they had a history of high-dose chemotherapy with stem-cell rescue, 92.5 MBq/m 2 per infusion (group B). The first infusion included 150 MBq of 111 Indium for scintigraphic verification of tumour targeting and dosimetry. 1.5 mg/kg epratuzumab was administered with each infusion. The treatment could be repeated once after 3 m. Results: Of 23 patients, 16 in group A and 6 in group B were evaluable for response. The RR in group A was 62% objective response (OR) and 25% CR/CRu. One patient in group B showed OR. OR was seen in aggressive and indolent lymphoma. Response was also long-lasting and event-free survival of patients showing CR/CRu was 14 to 25+ months. In group A all seven patient, receiving three infusions, showed less than grade 3 platelet and neutrophil toxicity, except for two patients suffering grade 3 neutropenia. Of five patients with 4 weekly infusions there were two patients with dose-limiting haematological toxicity (DLT), both recently treated with high dose cytosar before RIT. With criteria used the maximal tolerated dose was three infusions 185 MBq/m 2 . In group B no patient suffered DLT and one patient exhibited OR. Seven patients were retreated after 3 months with minor toxicity, but improvement in OR in two cases. No patient has developed HAHA. CD22 expression on tumour cells, as assessed by flow cytometry, is available in 18 of 22 patients. In group A, seven of eight patients with

  20. Connection-based and object-based grouping in multiple-object tracking: A developmental study

    NARCIS (Netherlands)

    R.E.R. van der Hallen (Ruth); Reusens, J. (Julie); Evers, K. (Kris); L. de-Wit (Lee); J. Wagemans (Johan)

    2018-01-01

    textabstractDevelopmental research on Gestalt laws has previously revealed that, even as young as infancy, we are bound to group visual elements into unitary structures in accordance with a variety of organizational principles. Here, we focus on the developmental trajectory of both connection-based

  1. Experimental studies of radioactive new formations of object 'Shelter'

    International Nuclear Information System (INIS)

    Vishnevskij, A.S.; Kuz'mina, I.E.; Tkach, V.N.; Tokarevskij, V.V.

    1996-01-01

    Chemical and phase composition of radioactive new-formations of object 'Shelter ' have been experimentally studied by the X-ray and local electronic probe methods of the substance analysis. Leaching of uranium is shown to be a result of attack by alkali-carbonate solutions, migration of uranium take place in the form of double alkali-carbonate system Na 4 [U O 2 (CO 3 ) 3 ]. Carbonates, sulphates, halite and probably sulphates-carbonates were found in the mineral association of new-formations. A hypothesis of formation of sodium uranyltetracarbonate Na 6 (U O 2 )(CO 3 ) 4 , under conditions of object 'Shelter' which was not described in scientific literature before has been advanced

  2. VIDEO GAMES ARE AN INTERESTING OBJECT TO THE COGNITION STUDIES

    Directory of Open Access Journals (Sweden)

    Cleci Maraschin

    2013-12-01

    Full Text Available Video games create a virtual space that can be inhabited in various ways by the players. Despite the controversies in which they are constantly included, electronic games bear witness to the modus operandi in our contemporary cognition permeated by technical objects. By focusing the know-how instead of a declarative experience the games open questions in the field of new literacies and problematize the use of technology in teaching practices. From the development of a locative game at the Botanical Garden of Porto Alegre, this article discussed some, methodological, political and theoretical implications arising from the research with video games in the field of cognitive studies. We discuss, finally, three theoretical / methodological implications the practice with video games forces us to think: research the video game through the process of its operation, questioning cognitive policies that organize our everyday and map the complex web of practices that supports the use of technical objects.

  3. Employing Machine-Learning Methods to Study Young Stellar Objects

    Science.gov (United States)

    Moore, Nicholas

    2018-01-01

    Vast amounts of data exist in the astronomical data archives, and yet a large number of sources remain unclassified. We developed a multi-wavelength pipeline to classify infrared sources. The pipeline uses supervised machine learning methods to classify objects into the appropriate categories. The program is fed data that is already classified to train it, and is then applied to unknown catalogues. The primary use for such a pipeline is the rapid classification and cataloging of data that would take a much longer time to classify otherwise. While our primary goal is to study young stellar objects (YSOs), the applications extend beyond the scope of this project. We present preliminary results from our analysis and discuss future applications.

  4. NEMD study for supercavitation mechanism with underwater object

    Energy Technology Data Exchange (ETDEWEB)

    Gong Bozhi [Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027 (China); Zhang Bingjian [Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027 (China)], E-mail: zbj@mail.ha.zj.cn; Zhang Hui [Department of Chemistry, Ohio State University, Columbus, OH 43210 (United States)

    2008-11-24

    An open system model was introduced for Non-Equilibrium Molecular Dynamics (NEMD) simulation for studying flow phenomenon surrounding different underwater object. Cavitation number {sigma} criterion was proved to be applicable in predicting local cavitation mechanism. An interesting phenomenon was found that low {sigma} areas and actual cavities were spatially separated in molecular scale, and stable supercavitation would require a large enough low {sigma} area to sustain. Effects of cavitator shape and flow velocity were compared with macro scale flow under similar {sigma}, providing a new computational method to study the molecular scale mechanism of this phenomenon.

  5. NEMD study for supercavitation mechanism with underwater object

    International Nuclear Information System (INIS)

    Gong Bozhi; Zhang Bingjian; Zhang Hui

    2008-01-01

    An open system model was introduced for Non-Equilibrium Molecular Dynamics (NEMD) simulation for studying flow phenomenon surrounding different underwater object. Cavitation number σ criterion was proved to be applicable in predicting local cavitation mechanism. An interesting phenomenon was found that low σ areas and actual cavities were spatially separated in molecular scale, and stable supercavitation would require a large enough low σ area to sustain. Effects of cavitator shape and flow velocity were compared with macro scale flow under similar σ, providing a new computational method to study the molecular scale mechanism of this phenomenon

  6. Actions Objected at Employees in CSR - Report from the Study

    Directory of Open Access Journals (Sweden)

    Szelągowska-Rudzka Katarzyna

    2016-12-01

    Full Text Available The study analyzed the essence of the social responsibility of organizations and indicated the areas of actions to which this concept applies in the organizations. Particular attention has been paid to CSR practices objected at employees as key stakeholders of the organization. The purpose of the study was achieved in the form of analysis of CSR practices addressed to employees of the selected organizations in the Pomeranian Voivodeship. It has been confirmed that the study subjects undertake socially responsible actions addressed to their employees. These actions are compliant with the guidelines of ISO 26000 standard in the area of practice in workplace. However, it has been shown that socially responsible objectives are not commonly present in the strategies of these organizations. Personal strategies and the knowledge of the concept of CSR among employees also occur not frequently enough. The presented study is a pilot study. The reached conclusions apply only to the participating organizations. However, it should be noted that the concept of CSR is not yet widely and successfully implemented in organizations within the Pomeranian Voivodeship. It requires further popularizing and intensifying. Also, the practices of CSR addressed to employees should be further improved.

  7. Youth suicide: an insight into previous hospitalisation for injury and sociodemographic conditions from a nationwide cohort study.

    Science.gov (United States)

    Zambon, Francesco; Laflamme, Lucie; Spolaore, Paolo; Visentin, Cristiana; Hasselberg, Marie

    2011-06-01

    This study investigates the degree to which a previous hospitalisation for injury of any intent is a risk of subsequent youth suicide and whether this association is influenced by family socioeconomic status or economic stress. A nationwide register-based cohort study was conducted covering all Swedish subjects born between January 1977 and December 1991 (N=1,616,342, male/female ratio=1.05). The cohort subjects were followed-up from January 1998 to December 2003, when aged 7-26 years. Poisson regression and the likelihood ratio test (95% CI) were used to assess the age-adjusted effect of hospitalisation for injuries of various intent on youth suicide and its effect once adjusted for family sociodemographic and social circumstances. Each set of exposures was associated independently and significantly with suicide mortality. Being hospitalised for self-inflicted injuries or injuries of undetermined intent was associated with a risk of suicide 36 to 47 times, respectively, that of subjects never hospitalised in the period under study (95% CI 28.36 to 45.58 and 26.67 to 83.87 for self-inflicted injuries and for events of undetermined intent, respectively; overall psuicide (RR 3.08; 95% CI 2.26 to 4.19). These effects were solid and not substantially altered after adjustment for family demographic and socioeconomic circumstances. A strong association exists between previous hospitalisation for injury of any intent and youth suicide. The association is robust and unaltered by family socioeconomic circumstances.

  8. Previous Fractures at Multiple Sites Increase the Risk for Subsequent Fractures: The Global Longitudinal Study of Osteoporosis in Women

    Science.gov (United States)

    Gehlbach, Stephen; Saag, Kenneth G.; Adachi, Jonathan D.; Hooven, Fred H.; Flahive, Julie; Boonen, Steven; Chapurlat, Roland D.; Compston, Juliet E.; Cooper, Cyrus; Díez-Perez, Adolfo; Greenspan, Susan L.; LaCroix, Andrea Z.; Netelenbos, J. Coen; Pfeilschifter, Johannes; Rossini, Maurizio; Roux, Christian; Sambrook, Philip N.; Silverman, Stuart; Siris, Ethel S.; Watts, Nelson B.; Lindsay, Robert

    2016-01-01

    Previous fractures of the hip, spine, or wrist are well-recognized predictors of future fracture, but the role of other fracture sites is less clear. We sought to assess the relationship between prior fracture at 10 skeletal locations and incident fracture. The Global Longitudinal Study of Osteoporosis in Women (GLOW) is an observational cohort study being conducted in 17 physician practices in 10 countries. Women ≥ 55 years answered questionnaires at baseline and at 1 and/or 2 years (fractures in previous year). Of 60,393 women enrolled, follow-up data were available for 51,762. Of these, 17.6%, 4.0%, and 1.6% had suffered 1, 2, or ≥3 fractures since age 45. During the first 2 years of follow-up, 3149 women suffered 3683 incident fractures. Compared with women with no prior fractures, women with 1, 2, or ≥ 3 prior fractures were 1.8-, 3.0-, and 4.8-fold more likely to have any incident fracture; those with ≥3 prior fractures were 9.1-fold more likely to sustain a new vertebral fracture. Nine of 10 prior fracture locations were associated with an incident fracture. The strongest predictors of incident spine and hip fractures were prior spine fracture (hazard ratio 7.3) and hip (hazard ratio 3.5). Prior rib fractures were associated with a 2.3-fold risk of subsequent vertebral fracture, previous upper leg fracture predicted a 2.2-fold increased risk of hip fracture; women with a history of ankle fracture were at 1.8-fold risk of future fracture of a weight-bearing bone. Our findings suggest that a broad range of prior fracture sites are associated with an increased risk of incident fractures, with important implications for clinical assessments and risk model development. PMID:22113888

  9. Previous experiences and emotional baggage as barriers to lifestyle change - a qualitative study of Norwegian Healthy Life Centre participants.

    Science.gov (United States)

    Følling, Ingrid S; Solbjør, Marit; Helvik, Anne-S

    2015-06-23

    Changing lifestyle is challenging and difficult. The Norwegian Directorate of Health recommends that all municipalities establish Healthy Life Centres targeted to people with lifestyle issues. Little is known about the background, experiences and reflections of participants. More information is needed about participants to shape effective lifestyle interventions with lasting effect. This study explores how participants in a lifestyle intervention programme describe previous life experiences in relation to changing lifestyle. Semi-structured qualitative in-depth interviews were performed with 23 participants (16 women and 7 men) aged 18 - 70 years. The data were analysed using systematic text condensation searching for issues describing participants' responses, and looking for the essence, aiming to share the basis of life-world experiences as valid knowledge. Participants identified two main themes: being stuck in old habits, and being burdened with emotional baggage from their previous negative experiences. Participants expressed a wish to change their lifestyles, but were unable to act in accordance with the health knowledge they possessed. Previous experiences with lifestyle change kept them from initiating attempts without professional assistance. Participants also described being burdened by an emotional baggage with problems from childhood and/or with family, work and social life issues. Respondents said that they felt that emotional baggage was an important explanation for why they were stuck in old habits and that conversely, being stuck in old habits added load to their already emotional baggage and made it heavier. Behavioural change can be hard to perform as psychological distress from life baggage can influence the ability to change. The study participants' experience of being stuck in old habits and having substantial emotional baggage raises questions as to whether or not Healthy Life Centres are able to help participants who need to make a lifestyle

  10. Everolimus for Previously Treated Advanced Gastric Cancer: Results of the Randomized, Double-Blind, Phase III GRANITE-1 Study

    Science.gov (United States)

    Ohtsu, Atsushi; Ajani, Jaffer A.; Bai, Yu-Xian; Bang, Yung-Jue; Chung, Hyun-Cheol; Pan, Hong-Ming; Sahmoud, Tarek; Shen, Lin; Yeh, Kun-Huei; Chin, Keisho; Muro, Kei; Kim, Yeul Hong; Ferry, David; Tebbutt, Niall C.; Al-Batran, Salah-Eddin; Smith, Heind; Costantini, Chiara; Rizvi, Syed; Lebwohl, David; Van Cutsem, Eric

    2013-01-01

    Purpose The oral mammalian target of rapamycin inhibitor everolimus demonstrated promising efficacy in a phase II study of pretreated advanced gastric cancer. This international, double-blind, phase III study compared everolimus efficacy and safety with that of best supportive care (BSC) in previously treated advanced gastric cancer. Patients and Methods Patients with advanced gastric cancer that progressed after one or two lines of systemic chemotherapy were randomly assigned to everolimus 10 mg/d (assignment schedule: 2:1) or matching placebo, both given with BSC. Randomization was stratified by previous chemotherapy lines (one v two) and region (Asia v rest of the world [ROW]). Treatment continued until disease progression or intolerable toxicity. Primary end point was overall survival (OS). Secondary end points included progression-free survival (PFS), overall response rate, and safety. Results Six hundred fifty-six patients (median age, 62.0 years; 73.6% male) were enrolled. Median OS was 5.4 months with everolimus and 4.3 months with placebo (hazard ratio, 0.90; 95% CI, 0.75 to 1.08; P = .124). Median PFS was 1.7 months and 1.4 months in the everolimus and placebo arms, respectively (hazard ratio, 0.66; 95% CI, 0.56 to 0.78). Common grade 3/4 adverse events included anemia, decreased appetite, and fatigue. The safety profile was similar in patients enrolled in Asia versus ROW. Conclusion Compared with BSC, everolimus did not significantly improve overall survival for advanced gastric cancer that progressed after one or two lines of previous systemic chemotherapy. The safety profile observed for everolimus was consistent with that observed for everolimus in other cancers. PMID:24043745

  11. Analytical techniques applied to study cultural heritage objects

    International Nuclear Information System (INIS)

    Rizzutto, M.A.; Curado, J.F.; Bernardes, S.; Campos, P.H.O.V.; Kajiya, E.A.M.; Silva, T.F.; Rodrigues, C.L.; Moro, M.; Tabacniks, M.; Added, N.

    2015-01-01

    The scientific study of artistic and cultural heritage objects have been routinely performed in Europe and the United States for decades. In Brazil this research area is growing, mainly through the use of physical and chemical characterization methods. Since 2003 the Group of Applied Physics with Particle Accelerators of the Physics Institute of the University of Sao Paulo (GFAA-IF) has been working with various methodologies for material characterization and analysis of cultural objects. Initially using ion beam analysis performed with Particle Induced X-Ray Emission (PIXE), Rutherford Backscattering (RBS) and recently Ion Beam Induced Luminescence (IBIL), for the determination of the elements and chemical compounds in the surface layers. These techniques are widely used in the Laboratory of Materials Analysis with Ion Beams (LAMFI-USP). Recently, the GFAA expanded the studies to other possibilities of analysis enabled by imaging techniques that coupled with elemental and compositional characterization provide a better understanding on the materials and techniques used in the creative process in the manufacture of objects. The imaging analysis, mainly used to examine and document artistic and cultural heritage objects, are performed through images with visible light, infrared reflectography (IR), fluorescence with ultraviolet radiation (UV), tangential light and digital radiography. Expanding more the possibilities of analysis, new capabilities were added using portable equipment such as Energy Dispersive X-Ray Fluorescence (ED-XRF) and Raman Spectroscopy that can be used for analysis 'in situ' at the museums. The results of these analyzes are providing valuable information on the manufacturing process and have provided new information on objects of different University of Sao Paulo museums. Improving the arsenal of cultural heritage analysis it was recently constructed an 3D robotic stage for the precise positioning of samples in the external beam setup

  12. Analytical techniques applied to study cultural heritage objects

    Energy Technology Data Exchange (ETDEWEB)

    Rizzutto, M.A.; Curado, J.F.; Bernardes, S.; Campos, P.H.O.V.; Kajiya, E.A.M.; Silva, T.F.; Rodrigues, C.L.; Moro, M.; Tabacniks, M.; Added, N., E-mail: rizzutto@if.usp.br [Universidade de Sao Paulo (USP), SP (Brazil). Instituto de Fisica

    2015-07-01

    The scientific study of artistic and cultural heritage objects have been routinely performed in Europe and the United States for decades. In Brazil this research area is growing, mainly through the use of physical and chemical characterization methods. Since 2003 the Group of Applied Physics with Particle Accelerators of the Physics Institute of the University of Sao Paulo (GFAA-IF) has been working with various methodologies for material characterization and analysis of cultural objects. Initially using ion beam analysis performed with Particle Induced X-Ray Emission (PIXE), Rutherford Backscattering (RBS) and recently Ion Beam Induced Luminescence (IBIL), for the determination of the elements and chemical compounds in the surface layers. These techniques are widely used in the Laboratory of Materials Analysis with Ion Beams (LAMFI-USP). Recently, the GFAA expanded the studies to other possibilities of analysis enabled by imaging techniques that coupled with elemental and compositional characterization provide a better understanding on the materials and techniques used in the creative process in the manufacture of objects. The imaging analysis, mainly used to examine and document artistic and cultural heritage objects, are performed through images with visible light, infrared reflectography (IR), fluorescence with ultraviolet radiation (UV), tangential light and digital radiography. Expanding more the possibilities of analysis, new capabilities were added using portable equipment such as Energy Dispersive X-Ray Fluorescence (ED-XRF) and Raman Spectroscopy that can be used for analysis 'in situ' at the museums. The results of these analyzes are providing valuable information on the manufacturing process and have provided new information on objects of different University of Sao Paulo museums. Improving the arsenal of cultural heritage analysis it was recently constructed an 3D robotic stage for the precise positioning of samples in the external beam setup

  13. Doxorubicin and ifosfamide combination chemotherapy in previously treated acute leukemia in adults: a Southwest Oncology Group pilot study.

    Science.gov (United States)

    Ryan, D H; Bickers, J N; Vial, R H; Hussein, K; Bottomley, R; Hewlett, J S; Wilson, H E; Stuckey, W J

    1980-01-01

    The Southwest Oncology Group did a limited institutional pilot study of the combination of doxorubicin and ifosfamide in the treatment of previously treated adult patients with acute leukemia. Thirty-four patients received one or two courses of the combination. All patients had received prior chemotherapy and 32 had received prior anthracycline chemotherapy. Three patients died before their responses could be fully evaluated. Fourteen patients achieved complete remission (41%) and one patient achieved partial remission. The complete remission rate was 27% for patients with acute myeloblastic leukemia (myelomonoblastic leukemia, monoblastic leukemia, and erythroleukemia) and 89% for patients with acute lymphocytic and undifferentiated leukemia (ALL). Toxic effects included severe hematologic reactions in 33 of 34 patients, hematuria in six patients, altered sensorium in one patient, and congestive heart failure in one patient. The safety of the combination was established and toxic side effects of this therapy were tolerable. The 89% complete remission rate for previously treated patients with ALL suggests that the combination of doxorubicin and ifosfamide may be particularly effective in ALL.

  14. An overview of the fire risk scoping study objectives, approach, findings and follow-on efforts

    International Nuclear Information System (INIS)

    Nowlen, S.P.; Lambright, J.A.; Nicolette, V.F.; Bohn, M.P.

    1989-01-01

    The Fire Risk Scoping Study was sponsored by the US Nuclear Regulatory Commission and performed at Sandia National Laboratories. The study was initiated as a result of previous USNRC-sponsored fire research efforts that had identified certain fire risk issues which had not been addressed in previously completed commercial nuclear power plant fire risk analyses. The specific objectives of this study were (1) to review and requantify fire risk scenarios from four fire probabilistic risk assessments (PRAs) in light of updated data bases made available as a result of USNRC sponsored Fire Protection Research Program and updated computer fire modeling capabilities, (2) to identify potentially significant fire risk issues that have not been previously addressed in a fire risk context and to quantify the potential impact of those identified fire risk issues where possible, and (3) to review current fire regulations and plant implementation practices for relevance to the identified unaddressed fire risk issues. 8 refs., 2 tabs

  15. Object Permanence and Relational Words: A Lexical Training Study.

    Science.gov (United States)

    Tomasello, Michael; Farrar, Michael Jeffrey

    1986-01-01

    Describes a lexical training program developed to teach object, visible movement, and invisible movement words to children at stage 5 (N=7) and stage 6 (N=16) object permanence development. Stage 6 children learned all three types of words equally well, while stage 5 children learned object and visible movement but not invisible movement words.…

  16. The suitability of XRF analysis for compositional classification of archaeological ceramic fabric: A comparison with a previous NAA study

    International Nuclear Information System (INIS)

    Padilla, R.; Espen, P. van; Torres, P.P. Godo

    2006-01-01

    The main drawbacks of EDXRF techniques, restricting its more frequent use for the specific purpose of compositional analysis of archaeological ceramic fabric, have been the insufficient sensitivity to determine some important elements (like Cr, REE, among others), a somewhat worse precision and the inability to perform standard-less quantitative procedures in the absence of suitable certified reference materials (CRM) for ceramic fabric. This paper presents the advantages of combining two energy dispersive X-ray fluorescence methods for fast and non-destructive analysis of ceramic fabric with increased sensitivity. Selective polarized excitation using secondary targets (EDPXRF) and radioisotope excitation (R-XRF) using a 241 Am source. The analytical performance of the methods was evaluated by analyzing several CRM of sediment type, and the fitness for the purpose of compositional classification was compared with that obtained by using Instrumental Neutron Activation Analysis in a previous study of Cuban aborigine pottery

  17. The suitability of XRF analysis for compositional classification of archaeological ceramic fabric: A comparison with a previous NAA study

    Energy Technology Data Exchange (ETDEWEB)

    Padilla, R. [Centro de Aplicaciones Tecnologicas y Desarrollo Nuclear (CEADEN), Laboratorio de Analisis Quimico, Calle 30 no. 502, Playa, Ciudad Habana (Cuba)]. E-mail: roman.padilla@infomed.sld.cu; Espen, P. van [University of Antwerp (Belgium); Torres, P.P. Godo [Centro de Antropologia, Havana (Cuba)

    2006-02-03

    The main drawbacks of EDXRF techniques, restricting its more frequent use for the specific purpose of compositional analysis of archaeological ceramic fabric, have been the insufficient sensitivity to determine some important elements (like Cr, REE, among others), a somewhat worse precision and the inability to perform standard-less quantitative procedures in the absence of suitable certified reference materials (CRM) for ceramic fabric. This paper presents the advantages of combining two energy dispersive X-ray fluorescence methods for fast and non-destructive analysis of ceramic fabric with increased sensitivity. Selective polarized excitation using secondary targets (EDPXRF) and radioisotope excitation (R-XRF) using a {sup 241}Am source. The analytical performance of the methods was evaluated by analyzing several CRM of sediment type, and the fitness for the purpose of compositional classification was compared with that obtained by using Instrumental Neutron Activation Analysis in a previous study of Cuban aborigine pottery.

  18. Value and reliability of findings from previous epidemiologic studies in the assessment of radiation-related cancer risks. Pt. 3

    International Nuclear Information System (INIS)

    Frasch, G.; Martignoni, K.

    1990-01-01

    The theories put forward here are predominantly based on pooled data from previous studies in a number of cohorts made up by mostly non-average individuals. These studies were carried out by various researchers and differed in procedures and aims. Factors of major importance to the validity and reliability of the conclusions drawn from this study are pointed out. In one chapter some light is thrown on factors known to bear a relation to the incidence of radiation-induced cancer of the breast, even though at present this can only very vaguely be described on a quantitative basis. These factors include fractionated dose regimens, pregnancies and parturitions, menarche, menopause, synergisms as well as secondary cancer of the breast. The available body of evidence suggests that exposure of each of 1 million women to a dose of 10 mGy (rad) can be linked with approx. 3 additional cases of mammary cancer reported on an average per year after the latency period. The fact that there is some statistical scatter around this value is chiefly attributable to age-related causes at the beginning of exposure. Differences in ethnic and cultural characteristics between the populations investigated appeared to be less important here. (orig./MG) [de

  19. Barriers to postpartum screening for type 2 diabetes: a qualitative study of women with previous gestational diabetes.

    Science.gov (United States)

    Rafii, Forough; Rahimparvar, Seyedeh Fatemeh Vasegh; Mehrdad, Neda; Keramat, Afsaneh

    2017-01-01

    Risk of developing type 2 diabetes is increased in women with previous gestational diabetes mellitus (GDM). Postpartum glycemic screening is recommended in women with recent GDM. But this screening rate is low and the reasons are unclear. The aim of this study was to explore the experiences of Iranian women with recent GDM on barriers of postpartum screening for diabetes. This qualitative study was conducted in Tehran, Iran in 2016. Semi-structured interview was used for data collection. 22 women with recent GDM were interviewed. These women gave birth in Tehran hospitals at a minimum of 6 months before interview. The missed screening defined as not attending to laboratory for Fasting Blood Sugar and/or Oral Glucose Tolerance Test, 6 week to 6 month after their child birthing. The data was analyzed by content analysis method. Themes and sub-themes that illustrated the barriers to postpartum diabetes screening were: inadequate education (about developing diabetes in the future, implementation of the screening, and glucometer validity in diagnosis of diabetes), perceiving the screening as difficult (feeling comfortable with the glucometer, poor laboratory conditions, issues related to the baby/babies, and financial problems), improper attitudes toward the screening (unwilling to get diagnosed, not giving priority to oneself, having false beliefs) and procrastination (gap to intention and action, self-deception and self-regulation failure). Women with recent GDM reported several barriers for postpartum diabetes screening. This study help to develop the evidence-based interventions for improving this screening rate.

  20. Arab Teens Lifestyle Study (ATLS): objectives, design, methodology and implications.

    Science.gov (United States)

    Al-Hazzaa, Hazzaa M; Musaiger, Abdulrahman O

    2011-01-01

    There is a lack of comparable data on physical activity, sedentary behavior, and dietary habits among Arab adolescents, which limits our understanding and interpretation of the relationship between obesity and lifestyle parameters. Therefore, we initiated the Arab Teens Lifestyle Study (ATLS). The ATLS is a multicenter collaborative project for assessing lifestyle habits of Arab adolescents. The objectives of the ATLS project were to investigate the prevalence rates for overweight and obesity, physical activity, sedentary activity and dietary habits among Arab adolescents, and to examine the interrelationships between these lifestyle variables. This paper reports on the objectives, design, methodology, and implications of the ATLS. The ATLS is a school-based cross-sectional study involving 9182 randomly selected secondary-school students (14-19 years) from major Arab cities, using a multistage stratified sampling technique. The participating Arab cities included Riyadh, Jeddah, and Al-Khobar (Saudi Arabia), Bahrain, Dubai (United Arab Emirates), Kuwait, Amman (Jordan), Mosel (Iraq), Muscat (Oman), Tunisia (Tunisia) and Kenitra (Morocco). Measured variables included anthropometric measurements, physical activity, sedentary behavior, sleep duration, and dietary habits. The ATLS project will provide a unique opportunity to collect and analyze important lifestyle information from Arab adolescents using standardized procedures. This is the first time a collaborative Arab project will simultaneously assess broad lifestyle variables in a large sample of adolescents from numerous urbanized Arab regions. This joint research project will supply us with comprehensive and recent data on physical activity/inactivity and eating habits of Arab adolescents relative to obesity. Such invaluable lifestyle-related data are crucial for developing public health policies and regional strategies for health promotion and disease prevention.

  1. A Flexible-Dose Study of Paliperidone ER in Patients With Nonacute Schizophrenia Previously Treated Unsuccessfully With Oral Olanzapine.

    Science.gov (United States)

    Kotler, Moshe; Dilbaz, Nesrin; Rosa, Fernanda; Paterakis, Periklis; Milanova, Vihra; Smulevich, Anatoly B; Lahaye, Marjolein; Schreiner, Andreas

    2016-01-01

    The goal of this study was to explore the tolerability, safety, and treatment response of switching from oral olanzapine to paliperidone extended release (ER). Adult patients with nonacute schizophrenia who had been treated unsuccessfully with oral olanzapine were switched to flexible doses of paliperidone ER (3 to 12 mg/d). The primary efficacy outcome was a ≥ 20% improvement in Positive and Negative Syndrome Scale (PANSS) total scores from baseline to endpoint for patients who switched medications because of lack of efficacy with olanzapine and noninferiority versus previous olanzapine treatment (mean endpoint change in PANSS total scores vs. baseline of ≤ 5 points) for patients who switched for reasons other than lack of efficacy. Safety and tolerability were assessed by monitoring adverse events, extrapyramidal symptoms, and weight change. Of 396 patients, 65.2% were men, mean age was 40.0 ± 12.0 years, and 75.5% had paranoid schizophrenia. Among the patients whose main reason for switching was lack of efficacy, an improvement in the PANSS total score of ≥ 20% occurred in 57.4% of patients. Noninferiority was confirmed for each subgroup of patients whose main reason for switching was something other than lack of efficacy. Paliperidone ER was generally well tolerated. Extrapyramidal symptoms as measured by total Extrapyramidal Symptom Rating Scale scores showed statistically significant and clinically relevant improvements at endpoint, the average weight decreased by 0.8 ± 5.2 kg at endpoint, and a clinically relevant weight gain of ≥ 7% occurred in 8.0% of patients. Paliperidone ER flexibly-dosed over 6 months was well tolerated and associated with a meaningful clinical response in patients with nonacute schizophrenia who had previously been unsuccessfully treated with oral olanzapine.

  2. Tracking moving objects with megavoltage portal imaging: A feasibility study

    International Nuclear Information System (INIS)

    Meyer, Juergen; Richter, Anne; Baier, Kurt; Wilbert, Juergen; Guckenberger, Matthias; Flentje, Michael

    2006-01-01

    Four different algorithms were investigated with the aim to determine their suitability to track an object in conventional megavoltage portal images. The algorithms considered were the mean of the sum of squared differences (MSSD), mutual information (MI), the correlation ratio (CR), and the correlation coefficient (CC). Simulation studies were carried out with various image series containing a rigid object of interest that was moved along a predefined trajectory. For each of the series the signal-to-noise ratio (SNR) was varied to compare the performance of the algorithms under noisy conditions. For a poor SNR of -6 dB the mean tracking error was 2.4, 6.5, 39.0, and 17.2 pixels for MSSD, CC, CR and MI, respectively, with a standard deviation of 1.9, 12.9, 19.5, and 7.5 pixels, respectively. The size of a pixel was 0.5 mm. These results improved to 1.1, 1.3, 1.3, and 2.0 pixels, respectively, with a standard deviation of 0.6, 0.8, 0.8, and 2.1 pixels, respectively, when a mean filter was applied to the images prior to tracking. The implementation of MSSD into existing in-house software demonstrated that, depending on the search range, it was possible to process between 2 and 15 images/s, making this approach capable of real-time applications. In conclusion, the best geometric tracking accuracy overall was obtained with MSSD, followed by CC, CR, and MI. The simplest and best algorithm, both in terms of geometric accuracy as well as computational cost, was the MSSD algorithm and was therefore the method of choice

  3. Arab Teens Lifestyle Study (ATLS: objectives, design, methodology and implications

    Directory of Open Access Journals (Sweden)

    Musaiger AO; ATLS Research Group

    2011-12-01

    Full Text Available Hazzaa M Al-Hazzaa1,2, Abdulrahman O Musaiger3, ATLS Research Group1Exercise Physiology Laboratory, Department of Physical Education and Movement Sciences, College of Education, King Saud University, 2Scientific Board, Obesity Research Chair, King Saud University, Riyadh, Saudi Arabia; 3Arab Center for Nutrition, Manama, Bahrain, and Nutrition and Health Studies Unit, Deanship of Scientific Research, University of Bahrain, BahrainBackground: There is a lack of comparable data on physical activity, sedentary behavior, and dietary habits among Arab adolescents, which limits our understanding and interpretation of the relationship between obesity and lifestyle parameters. Therefore, we initiated the Arab Teens Lifestyle Study (ATLS. The ATLS is a multicenter collaborative project for assessing lifestyle habits of Arab adolescents. The objectives of the ATLS project were to investigate the prevalence rates for overweight and obesity, physical activity, sedentary activity and dietary habits among Arab adolescents, and to examine the interrelationships between these lifestyle variables. This paper reports on the objectives, design, methodology, and implications of the ATLS.Design/Methods: The ATLS is a school-based cross-sectional study involving 9182 randomly selected secondary-school students (14–19 years from major Arab cities, using a multistage stratified sampling technique. The participating Arab cities included Riyadh, Jeddah, and Al-Khobar (Saudi Arabia, Bahrain, Dubai (United Arab Emirates, Kuwait, Amman (Jordan, Mosel (Iraq, Muscat (Oman, Tunisia (Tunisia and Kenitra (Morocco. Measured variables included anthropometric measurements, physical activity, sedentary behavior, sleep duration, and dietary habits.Discussion: The ATLS project will provide a unique opportunity to collect and analyze important lifestyle information from Arab adolescents using standardized procedures. This is the first time a collaborative Arab project will

  4. An Exploratory Study into the Efficacy of Learning Objects

    Directory of Open Access Journals (Sweden)

    Nicholas W. Farha, Ph.D.

    2009-07-01

    Full Text Available Learning objects have quickly become a widely accepted approach to instructional technology, particularly in on-line and computer-based learning environments. While there is a substantial body of literature concerning learning objects, very little of it verifies their efficacy. This research investigated the effectiveness of learning objects by comparing learning outcomes using a learning object with outcomes using a traditional textbook-based method of instruction. Participants were 327 undergraduate college students at a traditional public four-year coed institution, a private four-year women’s college, a private four-year engineering institution, and a public two-year community college. Through a series of independent samples t-tests and Analyses of Variance, results revealed mean scores for the learning object group that were nearly three times higher than the mean scores for the textbook-taught group. Gaming experience, age, gender, and learner preference were evaluated for their potential influence on the results; no statistically significant differences were found, implying that the learning object itself was central to the outcomes achieved. The future of learning objects is bright, and more empirical research is called for in the area of learning object effectiveness.

  5. Establishing Visual Category Boundaries between Objects: A PET Study

    Science.gov (United States)

    Saumier, Daniel; Chertkow, Howard; Arguin, Martin; Whatmough, Cristine

    2005-01-01

    Individuals with Alzheimer's disease (AD) often have problems in recognizing common objects. This visual agnosia may stem from difficulties in establishing appropriate visual boundaries between visually similar objects. In support of this hypothesis, Saumier, Arguin, Chertkow, and Renfrew (2001) showed that AD subjects have difficulties in…

  6. Pilot Study of an Individualised Early Postpartum Intervention to Increase Physical Activity in Women with Previous Gestational Diabetes

    Directory of Open Access Journals (Sweden)

    Harold David McIntyre

    2012-01-01

    Full Text Available Optimal strategies to prevent progression towards overt diabetes in women with recent gestational diabetes remain ill defined. We report a pilot study of a convenient, home based exercise program with telephone support, suited to the early post-partum period. Twenty eight women with recent gestational diabetes were enrolled at six weeks post-partum into a 12 week randomised controlled trial of Usual Care (n=13 versus Supported Care (individualised exercise program with regular telephone support; n=15. Baseline characteristics (Mean ± SD were: Age  33±4  years; Weight 80 ± 20 kg and Body Mass Index (BMI 30.0±9.7 kg/m2. The primary outcome, planned physical activity {Median (Range}, increased by 60 (0–540 mins/week in the SC group versus 0 (0–580 mins/week in the UC group (P=0.234. Walking was the predominant physical activity. Body weight, BMI, waist circumference, % body fat, fasting glucose and insulin did not change significantly over time in either group. This intervention designed to increase physical activity in post-partum women with previous gestational diabetes proved feasible. However, no measurable improvement in metabolic or biometric parameters was observed over a three month period.

  7. Patterns and Determinants of Treatment Seeking among Previously Untreated Psychotic Patients in Aceh Province, Indonesia: A Qualitative Study

    Directory of Open Access Journals (Sweden)

    Marthoenis Marthoenis

    2016-01-01

    Full Text Available Immediate treatment of first-episode psychosis is essential in order to achieve a positive outcome. However, Indonesian psychiatric patients often delay accessing health services, the reason for which is not yet fully understood. The current study aimed to understand patterns of treatment seeking and to reveal determinants of the delay in accessing psychiatric care among first-time user psychotic patients. Qualitative interviews were conducted with sixteen family members who accompanied the patients to a psychiatric hospital. Many families expressed beliefs that mental illness appertains to village sickness and not hospital sickness; therefore, they usually take the patients to traditional or religious healers before taking them to a health professional. They also identified various factors that potentially delay accessing psychiatric treatment: low literacy and beliefs about the cause of the illness, stigmatisation, the role of extended family, financial problems, and long distance to the psychiatric hospital. On the other hand, the family mentioned various factors related to timely help seeking, including being a well-educated family, living closer to health facilities, previous experience of successful psychotic therapy, and having more positive symptoms of psychosis. The findings call for mental health awareness campaigns in the community.

  8. Selective attention affects conceptual object priming and recognition: a study with young and older adults.

    Science.gov (United States)

    Ballesteros, Soledad; Mayas, Julia

    2014-01-01

    In the present study, we investigated the effects of selective attention at encoding on conceptual object priming (Experiment 1) and old-new recognition memory (Experiment 2) tasks in young and older adults. The procedures of both experiments included encoding and memory test phases separated by a short delay. At encoding, the picture outlines of two familiar objects, one in blue and the other in green, were presented to the left and to the right of fixation. In Experiment 1, participants were instructed to attend to the picture outline of a certain color and to classify the object as natural or artificial. After a short delay, participants performed a natural/artificial speeded conceptual classification task with repeated attended, repeated unattended, and new pictures. In Experiment 2, participants at encoding memorized the attended pictures and classify them as natural or artificial. After the encoding phase, they performed an old-new recognition memory task. Consistent with previous findings with perceptual priming tasks, we found that conceptual object priming, like explicit memory, required attention at encoding. Significant priming was obtained in both age groups, but only for those pictures that were attended at encoding. Although older adults were slower than young adults, both groups showed facilitation for attended pictures. In line with previous studies, young adults had better recognition memory than older adults.

  9. Selective attention affects conceptual object priming and recognition: A study with young and older adults

    Directory of Open Access Journals (Sweden)

    Soledad eBallesteros

    2015-01-01

    Full Text Available In the present study, we investigated the effects of selective attention at encoding on conceptual object priming (Experiment 1 and old-new recognition memory (Experiment 2 tasks in young and older adults. The procedures of both experiments included encoding and memory test phases separated by a short delay. At encoding, the picture outlines of two familiar objects, one in blue and the other in green, were presented to the left and to the right of fixation. In Experiment 1, participants were instructed to attend to the picture outline of a certain color and to classify the object as natural or artificial. After a short delay, participants performed a natural/ artificial speeded conceptual classification task with repeated attended, repeated unattended and new pictures. In Experiment 2, participants at encoding memorized the attended pictures and classified them as natural or artificial. After the encoding phase, they performed an old-new recognition memory task. Consistent with previous findings with perceptual priming tasks, we found that conceptual object priming, like explicit memory, required attention at encoding. Significant priming was obtained in both age groups, but only for those pictures that were attended at encoding. Although older adults were slower than young adults, both groups showed facilitation for attended pictures. In line with previous studies, young adults had better recognition memory than older adults.

  10. The effects of changes in object location on object identity detection: A simultaneous EEG-fMRI study.

    Science.gov (United States)

    Yang, Ping; Fan, Chenggui; Wang, Min; Fogelson, Noa; Li, Ling

    2017-08-15

    Object identity and location are bound together to form a unique integration that is maintained and processed in visual working memory (VWM). Changes in task-irrelevant object location have been shown to impair the retrieval of memorial representations and the detection of object identity changes. However, the neural correlates of this cognitive process remain largely unknown. In the present study, we aim to investigate the underlying brain activation during object color change detection and the modulatory effects of changes in object location and VWM load. To this end we used simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) recordings, which can reveal the neural activity with both high temporal and high spatial resolution. Subjects responded faster and with greater accuracy in the repeated compared to the changed object location condition, when a higher VWM load was utilized. These results support the spatial congruency advantage theory and suggest that it is more pronounced with higher VWM load. Furthermore, the spatial congruency effect was associated with larger posterior N1 activity, greater activation of the right inferior frontal gyrus (IFG) and less suppression of the right supramarginal gyrus (SMG), when object location was repeated compared to when it was changed. The ERP-fMRI integrative analysis demonstrated that the object location discrimination-related N1 component is generated in the right SMG. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. A Questionnaire Study on the Attitudes and Previous Experience of Croatian Family Physicians toward their Preparedness for Disaster Management.

    Science.gov (United States)

    Pekez-Pavliško, Tanja; Račić, Maja; Jurišić, Dinka

    2018-04-01

    To explore family physicians' attitudes, previous experience and self-assessed preparedness to respond or to assist in mass casualty incidents in Croatia. The cross-sectional survey was carried out during January 2017. Study participants were recruited through a Facebook group that brings together family physicians from Croatia. They were asked to complete the questionnaire, which was distributed via google.docs. Knowledge and attitudes toward disaster preparedness were evaluated by 18 questions. Analysis of variance, Student t test and Kruskal-Wallis test t were used for statistical analysis. Risk awareness of disasters was high among respondents (M = 4.89, SD=0.450). Only 16.4 of respondents have participated in the management of disaster at the scene. The majority (73.8%) of physicians have not been participating in any educational activity dealing with disaster over the past two years. Family physicians believed they are not well prepared to participate in national (M = 3.02, SD=0.856) and local community emergency response system for disaster (M = 3.16, SD=1.119). Male physicians scored higher preparedness to participate in national emergency response system for disaster ( p =0.012), to carry out accepted triage principles used in the disaster situation ( p =0.003) and recognize differences in health assessments indicating potential exposure to specific agents ( p =0,001) compared to their female colleagues. Croatian primary healthcare system attracts many young physicians, who can be an important part of disaster and emergency management. However, the lack of experience despite a high motivation indicates a need for inclusion of disaster medicine training during undergraduate studies and annual educational activities.

  12. Previous injuries and some training characteristics predict running-related injuries in recreational runners: a prospective cohort study.

    Science.gov (United States)

    Hespanhol Junior, Luiz Carlos; Pena Costa, Leonardo Oliveira; Lopes, Alexandre Dias

    2013-12-01

    What is the incidence of running-related injuries (RRIs) in recreational runners? Which personal and training characteristics predict RRIs in recreational runners? Prospective cohort study. A total of 200 recreational runners answered a fortnightly online survey containing questions about their running routine, races, and presence of RRI. These runners were followed-up for a period of 12 weeks. The primary outcome of this study was running-related injury. The incidence of injuries was calculated taking into account the exposure to running and was expressed by RRI/1000 hours. The association between potential predictive factors and RRIs was estimated using generalised estimating equation models. A total of 84 RRIs were registered in 60 (31%) of the 191 recreational runners who completed all follow-up surveys. Of the injured runners 30% (n=18/60) developed two or more RRIs, with 5/18 (28%) being recurrences. The incidence of RRI was 10 RRI/1000 hours of running exposure. The main type of RRI observed was muscle injuries (30%, n=25/84). The knee was the most commonly affected anatomical region (19%, n=16/84). The variables associated with RRI were: previous RRI (OR 1.88, 95% CI 1.01 to 3.51), duration of training although the effect was very small (OR 1.01, 95% CI 1.00 to 1.02), speed training (OR 1.46, 95% CI 1.02 to 2.10), and interval training (OR 0.61, 95% CI 0.43 to 0.88). Physiotherapists should be aware and advise runners that past RRI and speed training are associated with increased risk of further RRI, while interval training is associated with lower risk, although these associations may not be causative. Copyright © 2013 Australian Physiotherapy Association. Published by Elsevier B.V. All rights reserved.

  13. Objectives and status of EUROfusion DEMO blanket studies

    Energy Technology Data Exchange (ETDEWEB)

    Boccaccini, L.V., E-mail: lorenzo.boccaccini@kit.edu [Karlsruhe Institute of Technology (KIT) (Germany); Aiello, G.; Aubert, J. [CEA-Saclay, DEN, DM2S, SEMT, F-91191 Gif-sur-Yvette (France); Bachmann, C. [EUROfusion, PPPT, Garching (Germany); Barrett, T. [CCFE, Abingdon OX14 3DB (United Kingdom); Del Nevo, A. [ENEA CR Brasimone, 40032 Camugnano, BO (Italy); Demange, D. [Karlsruhe Institute of Technology (KIT) (Germany); Forest, L. [CEA-Saclay, DEN, DM2S, SEMT, F-91191 Gif-sur-Yvette (France); Hernandez, F.; Norajitra, P. [Karlsruhe Institute of Technology (KIT) (Germany); Porempovic, G. [Fuziotech Engineering Ltd (Hungary); Rapisarda, D. [CIEMAT, Avda. Complutense 40, 28040 Madrid (Spain); Sardain, P. [CEA/IRFM, 13115 Saint-Paul-lès-Durance (France); Utili, M. [ENEA CR Brasimone, 40032 Camugnano, BO (Italy); Vala, L. [Centrum výzkumu Řež, 250 68 Husinec-Řež (Czech Republic)

    2016-11-01

    Highlights: • Short description of the new Breeding Blanket Project in the EUROfusion consortium for the design of the EU PPPT DEMO: objectives. • Presentation of the design approach used in the development of the Breeding Blanket design: requirements. • Breeding Blanket design; in particular the four blanket concepts included in the study are presented, recent results highlighted and the status discussed. • Auxiliary systems and related R&D programme: in particular the work areas addressed in the Project (Tritium Technology, Pb-Li and Solid Breeders Technology, First Wall Design and R&D, Manufacturing) are presented, recent results highlighted and the status discussed. - Abstract: The design of a DEMO reactor requires the design of a blanket system suitable of reliable T production and heat extraction for electricity production. In the frame of the EUROfusion Consortium activities, the Breeding Blanket Project has been constituted in 2014 with the goal to develop concepts of Breeding Blankets for the EU PPPT DEMO; this includes an integrated design and R&D programme with the goal to select after 2020 concepts on fusion plants for the engineering phase. The design activities are presently focalized around a pool of solid and liquid breeder blanket with helium, water and PbLi cooling. Development of tritium extraction and control technology, as well manufacturing and development of solid and PbLi breeders are part of the programme.

  14. Study of archaeological objects by neutron imaging, xrd and xrf

    International Nuclear Information System (INIS)

    Dinca, M.; Dinu, A. D.; Stanciulescu, M. G.; Mandescu, D.

    2015-01-01

    Archaeological objects were borrowed from Arges County History Museum (ACHM) and investigated at the Institute for Nuclear Research (INR). Metallic objects made in iron, copper alloys and silver discovered in southern part of Romania, mostly Dacian and Roman origin, were investigated. For imaging was used the neutron and gamma imaging facility from tangential channel of the TRIGA ACPR to put in evidence the internal structure of the objects. For elemental and chemical composition, concentration levels in objects were performed investigations by X-ray fluorescence (XRF) and X-ray diffraction (XRD). These investigations offer valuable information in archaeological research about composition, structure of the bulk, presence of alteration, inclusions, typology of the location of material extraction, manufacturing techniques etc. This work is an example of application of neutron imaging and other radiation-based analytical methods for cultural heritage research that had the aim to involve some of the non-destructive investigation methods available at INR. (authors)

  15. 31 OBJECTIVE ORIENTED PROBLEM SOLVING A Case Study ...

    African Journals Online (AJOL)

    succeed but which are not Wlder the direct control of the activities ..... Frequent failure of electrical machines due to intenuption .... suffers high attribution rate of skilled personnel and as a result is .... Management and Objective Oriented Project.

  16. CHRONOVAC VOYAGEUR: A study of the immune response to yellow fever vaccine among infants previously immunized against measles.

    Science.gov (United States)

    Goujon, Catherine; Gougeon, Marie-Lise; Tondeur, Laura; Poirier, Béatrice; Seffer, Valérie; Desprès, Philippe; Consigny, Paul-Henri; Vray, Muriel

    2017-10-27

    For administration of multiple live attenuated vaccines, the Advisory Committee on Immunization Practices recommends either simultaneous immunization or period of at least 28days between vaccines, due to a possible reduction in the immune response to either vaccine. The main objective of this study was to compare the immune response to measles (alone or combined with mumps and rubella) and yellow fever vaccines among infants aged 6-24months living in a yellow fever non-endemic country who had receivedmeasles and yellow fever vaccines before travelling to a yellow fever endemic area. A retrospective, multicenter case-control study was carried out in 7 travel clinics in the Paris area from February 1st 2011 to march 31, 2015. Cases were defined as infants immunized with the yellow fever vaccine and with the measles vaccine, either alone or in combination with mumps and rubella vaccine, with a period of 1-27days between each immunization. For each case, two controls were matched based on sex and age: a first control group (control 1) was defined as infants having received the measles vaccine and the yellow fever vaccine simultaneously; a second control group (control 2) was defined as infants who had a period of more than 27days between receiving the measles vaccine and yellow fever vaccine. The primary endpoint of the study was the percentage of infants with protective immunity against yellow fever, measured by the titer of neutralizing antibodies in a venous blood sample. One hundred and thirty-one infants were included in the study (62 cases, 50 infants in control 1 and 19 infants in control 2). Of these, 127 (96%) were shown to have a protective titer of yellow fever antibodies. All 4 infants without a protective titer of yellow fever antibodies were part of control group 1. The measles vaccine, alone or combined with mumps and rubella vaccines, appears to have no influence on humoral immune response to the yellow fever vaccine when administered between 1 and 27

  17. Real-time object-oriented programming: studies and proposals

    International Nuclear Information System (INIS)

    Fouquier, Gilles

    1996-01-01

    This thesis contributes to the introduction of real-time features in object-oriented programming. Object-oriented programming favours modularity and reusability. Therefore, its application to real-time introduces many theoretical and conceptual problems. To deal with these problems, a new real-time object-oriented programming model is presented. This model is based on the active object model which allows concurrence and maintains the encapsulation property. The real-time aspect is treated by replacing the concept of task by the concept of method processing and by associating a real-time constraint to each message (priority or deadline). The set of all the running methods is scheduled. This model, called ATOME, contains several sub-models to deal with the usual concurrence control integrating their priority and deadline processing. The classical HPF and EDF scheduling avoid priority or deadline inversion. This model and its variants are new proposals to program real-time applications in the object-oriented way, therefore easing reusability and code writing. The feasibility of this approach is demonstrated by extending and existing active object-based language to real-time, in using the rules defined in the ATOME model. (author) [fr

  18. Blood donations from previously transfused or pregnant donors: a multicenter study to determine the frequency of alloexposure.

    Science.gov (United States)

    Rios, Jorge A; Schlumpf, Karen S; Kakaiya, Ram M; Triulzi, Darrell J; Roback, John D; Kleinman, Steve H; Murphy, Edward L; Gottschall, Jerome L; Carey, Patricia M

    2011-06-01

    Transfusion-related acute lung injury (TRALI) mitigation strategies include the deferral of female donors from apheresis platelet (PLT) donations and the distribution of plasma for transfusion from male donors only. We studied the implications of these policies in terms of component loss at six blood centers in the United States. We collected data from allogeneic blood donors making whole blood and blood component donations during calendar years 2006 through 2008. We analyzed the distribution of donations in terms of the sex, transfusion and pregnancy histories, and blood type. A TRALI mitigation policy that would not allow plasma from female whole blood donors to be prepared into transfusable plasma components would result in nearly a 50% reduction in the units of whole blood available for plasma manufacturing and would decrease the number of type AB plasma units that could be made from whole blood donations by the same amount. Deferral of all female apheresis PLT donors, all female apheresis PLT donors with histories of prior pregnancies, or all female apheresis PLT donors with histories of prior pregnancies and positive screening test results for antibodies to human leukocyte antigens (HLAs) will result in a loss of 37.1, 22.5, and 5.4% of all apheresis PLT donations, respectively. A TRALI mitigation policy that only defers female apheresis PLT donors with previous pregnancies and HLAs would result in an approximately 5% decrease in the inventory of apheresis PLTs, but would eliminate a large proportion of components that are associated with TRALI. © 2010 American Association of Blood Banks.

  19. PCNL - a comparative study in nonoperated and in previously operated (open nephrolithotomy/pyelolithotomy patients - a single-surgeon experience

    Directory of Open Access Journals (Sweden)

    Rahul Gupta

    2011-12-01

    Full Text Available PURPOSE: Re-procedure in patients with history of open stone surgery is usually challenging due to the alteration in the retroperitoneal anatomy. The aim of this study was to determine the possible impact of open renal surgery on the efficacy and morbidity of subsequent percutaneous nephrolithotomy (PCNL. MATERIALS AND METHODS: From March 2009 until September 2010, 120 patients underwent PCNL. Of these, 20 patients were excluded (tubeless or bilateral simultaneous PCNL. Of the remaining 100, 55 primary patients were categorized as Group 1 and the remaining (previous open nephrolithotomy as Group 2. Standard preoperative evaluation was carried out prior to intervention, Statistical analysis was performed using SPSS v. 11 with the chi-square test, independent samples t-test, and Mann-Whitney U test. A p-value < 0.05 was taken as statistically significant. RESULTS: Both groups were similar in demographic profile and stone burden. Attempts to access the PCS was less in Group 1 compared to Group 2 (1.2 + 1 2 vs 3 + 1.3 respectively and this was statistically significant (p < 0.04. However, the mean operative time between the two groups was not statistically significant (p = 0.44. Blood transfusion rate was comparable in the two groups (p = 0.24. One patient in Group 2 developed hemothorax following a supra-11th puncture. Remaining complications were comparable in both groups. CONCLUSION: Patients with past history of renal stone surgery may need more attempts to access the pelvicaliceal system and have difficulty in tract dilation secondary to retroperitoneal scarring. But overall morbidity and efficacy is same in both groups.

  20. X-ray studies of BL Lacertae objects

    International Nuclear Information System (INIS)

    Madejski, G.M.

    1986-01-01

    This thesis presents spectral x-ray data for BL Lac objects observed by the IPC and MPC aboard the Einstein Observatory and interprets that data in a context of their overall radiation spectra using synchrotron and synchrotron self-Compton models. The objects considered are: OJ 287, PKS 0735 + 178, I Zw 186, PKS 0548-322, Mkn 180, BL Lacertae, PKS 2155-304, H 0414-009 and H 0323 + 022. X-ray spectra of BL Lac objects are well described by a power law model with a low energy cutoff due to absorption within the own Galaxy. The best fit values of the energy spectral index α in the IPC (0.2-4.0 keV) band range from 0.73 to 2.35, with a mean of 1.2 and rms spread of 0.51. No single, universal index can fit the spectra of all objects. For all objects except PKS 0735 + 178, the x-ray spectrum is an extrapolation of the infrared/optical UV spectrum; in PKS 0735 + 178, the x-ray spectrum lies significantly below such an extrapolation. The overall electromagnetic distribution in those objects is interpreted as arising due to the synchrotron process in at least two spatial regions, with sizes respectively ∼10 18 cm for the radio component and ∼10 16 cm for the optical component. In objects where the x-ray spectrum lies on the extrapolation of the infrared-optical-ultraviolet spectrum, the x-ray emission is interpreted also to be due to the synchrotron process

  1. Visual Servoing for Object Manipulation: A Case Study in Slaughterhouse

    DEFF Research Database (Denmark)

    Wu, Haiyan; Andersen, Thomas Timm; Andersen, Nils Axel

    2016-01-01

    Automation for slaughterhouse challenges the design of the control system due to the variety of the objects. Realtime sensing provides instantaneous information about each piece of work and thus, is useful for robotic system developed for slaughterhouse. In this work, a pick and place task which....... An online and offline combined path planning algorithm is proposed to generate the desired path for the robot control. An industrial robot arm is applied to execute the path. The system is implemented for a lab-scale experiment, and the results show a high success rate of object manipulation in the pick...

  2. Laparoscopy After Previous Laparotomy

    Directory of Open Access Journals (Sweden)

    Zulfo Godinjak

    2006-11-01

    Full Text Available Following the abdominal surgery, extensive adhesions often occur and they can cause difficulties during laparoscopic operations. However, previous laparotomy is not considered to be a contraindication for laparoscopy. The aim of this study is to present that an insertion of Veres needle in the region of umbilicus is a safe method for creating a pneumoperitoneum for laparoscopic operations after previous laparotomy. In the last three years, we have performed 144 laparoscopic operations in patients that previously underwent one or two laparotomies. Pathology of digestive system, genital organs, Cesarean Section or abdominal war injuries were the most common causes of previouslaparotomy. During those operations or during entering into abdominal cavity we have not experienced any complications, while in 7 patients we performed conversion to laparotomy following the diagnostic laparoscopy. In all patients an insertion of Veres needle and trocar insertion in the umbilical region was performed, namely a technique of closed laparoscopy. Not even in one patient adhesions in the region of umbilicus were found, and no abdominal organs were injured.

  3. The functional neuroanatomy of object agnosia: a case study.

    Science.gov (United States)

    Konen, Christina S; Behrmann, Marlene; Nishimura, Mayu; Kastner, Sabine

    2011-07-14

    Cortical reorganization of visual and object representations following neural injury was examined using fMRI and behavioral investigations. We probed the visual responsivity of the ventral visual cortex of an agnosic patient who was impaired at object recognition following a lesion to the right lateral fusiform gyrus. In both hemispheres, retinotopic mapping revealed typical topographic organization and visual activation of early visual cortex. However, visual responses, object-related, and -selective responses were reduced in regions immediately surrounding the lesion in the right hemisphere, and also, surprisingly, in corresponding locations in the structurally intact left hemisphere. In contrast, hV4 of the right hemisphere showed expanded response properties. These findings indicate that the right lateral fusiform gyrus is critically involved in object recognition and that an impairment to this region has widespread consequences for remote parts of cortex. Finally, functional neural plasticity is possible even when a cortical lesion is sustained in adulthood. Copyright © 2011 Elsevier Inc. All rights reserved.

  4. Applying of component system development in object methodology, case study

    Directory of Open Access Journals (Sweden)

    Milan Mišovič

    2013-01-01

    Full Text Available To create computarization target software as a component system has been a very strong requirement for the last 20 years of software developing. Finally, the architectural components are self-contained units, presenting not only partial and overall system behavior, but also cooperating with each other on the basis of their interfaces. Among others, components have allowed flexible modification of processes the behavior of which is the foundation of components behavior without changing the life of the component system. On the other hand, the component system makes it possible, at design time, to create numerous new connections between components and thus creating modified system behaviors. This all enables the company management to perform, at design time, required behavioral changes of processes in accordance with the requirements of changing production and market.The development of software which is generally referred to as SDP (Software Development Process contains two directions. The first one, called CBD (Component–Based Development, is dedicated to the development of component–based systems CBS (Component–based System, the second target is the development of software under the influence of SOA (Service–Oriented Architecture. Both directions are equipped with their different development methodologies. The subject of this paper is only the first direction and application of development of component–based systems in its object–oriented methodologies. The requirement of today is to carry out the development of component-based systems in the framework of developed object–oriented methodologies precisely in the way of a dominant style. In some of the known methodologies, however, this development is not completely transparent and is not even recognized as dominant. In some cases, it is corrected by the special meta–integration models of component system development into an object methodology.This paper presents a case study

  5. Correction of bias in belt transect studies of immotile objects

    Science.gov (United States)

    Anderson, D.R.; Pospahala, R.S.

    1970-01-01

    Unless a correction is made, population estimates derived from a sample of belt transects will be biased if a fraction of, the individuals on the sample transects are not counted. An approach, useful for correcting this bias when sampling immotile populations using transects of a fixed width, is presented. The method assumes that a searcher's ability to find objects near the center of the transect is nearly perfect. The method utilizes a mathematical equation, estimated from the data, to represent the searcher's inability to find all objects at increasing distances from the center of the transect. An example of the analysis of data, formation of the equation, and application is presented using waterfowl nesting data collected in Colorado.

  6. Vitamin D deficiency in medical patients at a central hospital in Malawi: a comparison with TB patients from a previous study.

    Directory of Open Access Journals (Sweden)

    Yamikani Mastala

    Full Text Available OBJECTIVES: To determine the prevalence of vitamin D deficiency (VDD in adult medical, non-tuberculous (non-TB patients. To investigate associations with VDD. To compare the results with a similar study in TB patients at the same hospital. DESIGN: Cross-sectional sample. SETTING: Central hospital in Malawi. PARTICIPANTS: Adult non-TB patients (n = 157, inpatients and outpatients. OUTCOME MEASURES: The primary outcome was the prevalence of VDD. Potentially causal associations sought included nutritional status, in/outpatient status, HIV status, anti-retroviral therapy (ART and, by comparison with a previous study, a diagnosis of tuberculosis (TB. RESULTS: Hypovitaminosis D (≤75 nmol/L occurred in 47.8% (75/157 of patients, 16.6% (26/157 of whom had VDD (≤50 nmol/L. None had severe VDD (≤25 nmol/L. VDD was found in 22.8% (23/101 of in-patients and 5.4% (3/56 of out-patients. In univariable analysis in-patient status, ART use and low dietary vitamin D were significant predictors of VDD. VDD was less prevalent than in previously studied TB patients in the same hospital (68/161 = 42%. In multivariate analysis of the combined data set from both studies, having TB (OR 3.61, 95%CI 2.02-6.43 and being an in-patient (OR 2.70, 95%CI 1.46-5.01 were significant independent predictors of VDD. CONCLUSIONS: About half of adult medical patients without TB have suboptimal vitamin D status, which is more common in in-patients. VDD is much more common in TB patients than non-TB patients, even when other variables are controlled for, suggesting that vitamin D deficiency is associated with TB.

  7. Increasing incidence of statin prescribing for the elderly without previous cardiovascular conditions:  A nation wide register study

    DEFF Research Database (Denmark)

    Kildemoes, Helle Wallach; Andersen, Morten

    Supported by the growing evidence of the beneficial effects of statins in a range of conditions, statin utilization has increased considerably in most Western countries over the last decade. Objectives To estimate to what extent a widening of indication scope for statins accounts for the increasing...... Danish statin utilization during 1996-2005, applying treatment incidence as a measure of changing prescribing behaviour Methods From three nationwide registers, we retrieved individual records on demographics, dispensed prescription drugs and hospital discharges. Danish inhabitants were followed...... for seven cardiovascular conditions, corresponding to a hierarchy of statin indications. Poisson regression analyses were applied to quantify the incidence growth, according to age and indication.  Results Treatment incidence increased from 4/1000 person years in 2000 to 17/1000 in 2005, the increase being...

  8. Trial of labour and vaginal birth after previous caesarean section: A population based study of Eastern African immigrants in Victoria, Australia.

    Science.gov (United States)

    Belihu, Fetene B; Small, Rhonda; Davey, Mary-Ann

    2017-03-01

    Variations in caesarean section (CS) between some immigrant groups and receiving country populations have been widely reported. Often, African immigrant women are at higher risk of CS than the receiving population in developed countries. However, evidence about subsequent mode of birth following CS for African women post-migration is lacking. The objective of this study was to examine differences in attempted and successful vaginal birth after previous caesarean (VBAC) for Eastern African immigrants (Eritrea, Ethiopia, Somalia and Sudan) compared with Australian-born women. A population-based observational study was conducted using the Victorian Perinatal Data Collection. Pearson's chi-square test and logistic regression analysis were performed to generate adjusted odds ratios for attempted and successful VBAC. Victoria, Australia. 554 Eastern African immigrants and 24,587 Australian-born eligible women with previous CS having singleton births in public care. 41.5% of Eastern African immigrant women and 26.1% Australian-born women attempted a VBAC with 50.9% of Eastern African immigrants and 60.5% of Australian-born women being successful. After adjusting for maternal demographic characteristics and available clinical confounding factors, Eastern African immigrants were more likely to attempt (OR adj 1.94, 95% CI 1.57-2.47) but less likely to succeed (OR adj 0.54 95% CI 0.41-0.71) in having a VBAC. There are disparities in attempted and successful VBAC between Eastern African origin and Australian-born women. Unsuccessful VBAC attempt is more common among Eastern African immigrants, suggesting the need for improved strategies to select and support potential candidates for vaginal birth among these immigrants to enhance success and reduce potential complications associated with failed VBAC attempt. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  9. Subsequent pregnancy outcome after previous foetal death

    NARCIS (Netherlands)

    Nijkamp, J. W.; Korteweg, F. J.; Holm, J. P.; Timmer, A.; Erwich, J. J. H. M.; van Pampus, M. G.

    Objective: A history of foetal death is a risk factor for complications and foetal death in subsequent pregnancies as most previous risk factors remain present and an underlying cause of death may recur. The purpose of this study was to evaluate subsequent pregnancy outcome after foetal death and to

  10. A Study of Neutron Leakage in Finite Objects

    Science.gov (United States)

    Wilson, John W.; Slaba, Tony C.; Badavi, Francis F.; Reddell, Brandon D.; Bahadori, Amir A.

    2015-01-01

    A computationally efficient 3DHZETRN code capable of simulating High charge (Z) and Energy (HZE) and light ions (including neutrons) under space-like boundary conditions with enhanced neutron and light ion propagation was recently developed for simple shielded objects. Monte Carlo (MC) benchmarks were used to verify the 3DHZETRN methodology in slab and spherical geometry, and it was shown that 3DHZETRN agrees with MC codes to the degree that various MC codes agree among themselves. One limitation in the verification process is that all of the codes (3DHZETRN and three MC codes) utilize different nuclear models/databases. In the present report, the new algorithm, with well-defined convergence criteria, is used to quantify the neutron leakage from simple geometries to provide means of verifying 3D effects and to provide guidance for further code development.

  11. Optical polarization studies of Herbig-Haro objects: Pt. 4

    International Nuclear Information System (INIS)

    Scarrott, S.M.

    1988-01-01

    Optical polarization maps are presented for the various nebulosities of the HH34 complex in the L1641 dark cloud. The Herbig-Haro object HH34 and its associated optical jet are unpolarized but their source of excitation (HH34-IRS) is the illuminating star of a reflection nebula which envelops the jet and extends as far as HH34. The optical polarization of HH34-IRS suggests that it is surrounded by a circumstellar disc which collimates the outflows in some manner. There is other reflection nebulosity in the region illuminated by a faint star which we identify as the optical counterpart of HH34-IRS5. We have also discovered a small bipolar reflection nebula approximately 20 arcsec west of HH34-IRS. (author)

  12. A case study of IMRT planning (Plan B) subsequent to a previously treated IMRT plan (Plan A)

    International Nuclear Information System (INIS)

    2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" data-affiliation=" (Department of Medical Physics and 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" >Cao, F; 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" data-affiliation=" (Department of Medical Physics and 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" >Leong, C; 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" data-affiliation=" (Department of Medical Physics and 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" >Schroeder, J; 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" data-affiliation=" (Department of Medical Physics and 2Department of Radiation Oncology, Fraser Valley Centre, BC Cancer Agency, Surrey, British Columbia (Canada))" >Lee, B

    2014-01-01

    Background and purpose: Treatment of the contralateral neck after previous ipsilateral intensity modulated radiation therapy (IMRT) for head and neck cancer is a challenging problem. We have developed a technique that limits the cumulative dose to the spinal cord and brainstem while maximizing coverage of a planning target volume (PTV) in the contralateral neck. Our case involves a patient with right tonsil carcinoma who was given ipsilateral IMRT with 70Gy in 35 fractions (Plan A). A left neck recurrence was detected 14 months later. The patient underwent a neck dissection followed by postoperative left neck radiation to a dose of 66 Gy in 33 fractions (Plan B). Materials and Methods: The spinal cord-brainstem margin (SCBM) was defined as the spinal cord and brainstem with a 1.0 cm margin. Plan A was recalculated on the postoperative CT scan but the fluence outside of SCBM was deleted. A further modification of Plan A resulted in a base plan that was summed with Plan B to evaluate the cumulative dose received by the spinal cord and brainstem. Plan B alone was used to evaluate for coverage of the contralateral neck PTV. Results: The maximum cumulative doses to the spinal cord with 0.5cm margin and brainstem with 0.5cm margin were 51.96 Gy and 45.60 Gy respectively. For Plan B, 100% of the prescribed dose covered 95% of PTVb1. Conclusion: The use of a modified ipsilateral IMRT plan as a base plan is an effective way to limit the cumulative dose to the spinal cord and brainstem while enabling coverage of a PTV in the contralateral neck.

  13. Evaluation of a rapid dipstick (Crystal VC for the diagnosis of cholera in Zanzibar and a comparison with previous studies.

    Directory of Open Access Journals (Sweden)

    Benedikt Ley

    Full Text Available The gold standard for the diagnosis of cholera is stool culture, but this requires laboratory facilities and takes at least 24 hours. A rapid diagnostic test (RDT that can be used by minimally trained staff at treatment centers could potentially improve the reporting and management of cholera outbreaks.We evaluated the Crystal VC™ RDT under field conditions in Zanzibar in 2009. Patients presenting to treatment centers with watery diarrhea provided a stool sample for rapid diagnostic testing. Results were compared to stool culture performed in a reference laboratory. We assessed the overall performance of the RDT and evaluated whether previous intake of antibiotics, intravenous fluids, location of testing, and skill level of the technician affected the RDT results.We included stool samples from 624 patients. Compared to culture, the overall sensitivity of the RDT was 93.1% (95%CI: 88.7 to 96.2%, specificity was 49.2% (95%CI: 44.3 to 54.1%, the positive predictive value was 47.0% (95%CI: 42.1 to 52.0% and the negative predictive value was 93.6% (95%CI: 89.6 to 96.5%. The overall false positivity rate was 50.8% (213/419; fieldworkers frequently misread very faint test lines as positive.The observed sensitivity of the Crystal VC RDT evaluated was similar compared to earlier versions, while specificity was poorer. The current version of the RDT could potentially be used as a screening tool in the field. Because of the high proportion of false positive results when field workers test stool specimens, positive results will need to be confirmed with stool culture.

  14. A Pilot Study of Hypofractionated Stereotactic Radiation Therapy and Sunitinib in Previously Irradiated Patients With Recurrent High-Grade Glioma

    International Nuclear Information System (INIS)

    Wuthrick, Evan J.; Curran, Walter J.; Camphausen, Kevin; Lin, Alexander; Glass, Jon; Evans, James; Andrews, David W.; Axelrod, Rita; Shi, Wenyin; Werner-Wasik, Maria; Haacke, E. Mark; Hillman, Gilda G.; Dicker, Adam P.

    2014-01-01

    Purpose/Objective(s): Angiogenic blockade with irradiation may enhance the therapeutic ratio of radiation therapy (RT) through vascular normalization. We sought to determine the safety and toxicity profile of continuous daily-dosed sunitinib when combined with hypofractionated stereotactic RT (fSRT) for recurrent high-grade gliomas (rHGG). Methods and Materials: Eligible patients had malignant high-grade glioma that recurred or progressed after primary surgery and RT. All patients received a minimum of a 10-day course of fSRT, had World Health Organization performance status of 0 to 1, and a life expectancy of >3 months. During fSRT, sunitinib was administered at 37.5 mg daily. The primary endpoint was acute toxicity, and response was assessed via serial magnetic resonance imaging. Results: Eleven patients with rHGG were enrolled. The fSRT doses delivered ranged from 30 to 42 Gy in 2.5- to 3.75-Gy fractions. The median follow-up time was 40 months. Common acute toxicities included hematologic disorders, fatigue, hypertension, and elevated liver transaminases. Sunitinib and fSRT were well tolerated. One grade 4 mucositis toxicity occurred, and no grade 4 or 5 hypertensive events or intracerebral hemorrhages occurred. One patient had a nearly complete response, and 4 patients had stable disease for >9 months. Two patients (18%) remain alive and progression-free >3 years from enrollment. The 6-month progression-free survival was 45%. Conclusions: Sunitinib at a daily dose of 37.5 mg given concurrently with hypofractionated stereotactic reirradiation for rHGG yields acceptable toxicities and an encouraging 6-month progression-free survival

  15. SARC009: Phase 2 study of dasatinib in patients with previously treated, high-grade, advanced sarcoma.

    Science.gov (United States)

    Schuetze, Scott M; Wathen, J Kyle; Lucas, David R; Choy, Edwin; Samuels, Brian L; Staddon, Arthur P; Ganjoo, Kristen N; von Mehren, Margaret; Chow, Warren A; Loeb, David M; Tawbi, Hussein A; Rushing, Daniel A; Patel, Shreyaskumar R; Thomas, Dafydd G; Chugh, Rashmi; Reinke, Denise K; Baker, Laurence H

    2016-03-15

    Dasatinib exhibited activity in preclinical models of sarcoma. The Sarcoma Alliance for Research through Collaboration (SARC) conducted a multicenter, phase 2 trial of dasatinib in patients with advanced sarcoma. Patients received dasatinib twice daily. The primary objective was to estimate the clinical benefit rate (CBR) (complete response or partial response within 6 months or stable disease duration of ≥6 months) with a target of ≥25%. Patients were enrolled into 1 of 7 different cohorts and assessed by imaging every 8 weeks using Choi criteria tumor response and a Bayesian hierarchical design. For each subtype, enrollment was stopped after a minimum of 9 patients were treated if there was a sarcoma (UPS) cohorts fully accrued and 6 of 47 and 8 of 42 evaluable patients, respectively, exhibited clinical benefit. The probability that the CBR was ≥25% in the LMS and UPS cohorts was 0.008 and 0.10, respectively. The median progression-free survival ranged from 0.9 months in patients with rhabdomyosarcoma to 2.2 months in patients with LMS. The median overall survival was 8.6 months. The most frequent adverse events were constitutional, gastrointestinal, and respiratory, and 36% of patients required dose reduction for toxicity. Serious adverse events attributed to therapy occurred in 11% of patients. Dasatinib may have activity in patients with UPS but is inactive as a single agent in the other sarcoma subtypes included herein. The Bayesian design allowed for the early termination of accrual in 5 subtypes because of lack of drug activity. © 2015 American Cancer Society.

  16. A Pilot Study of Hypofractionated Stereotactic Radiation Therapy and Sunitinib in Previously Irradiated Patients With Recurrent High-Grade Glioma

    Energy Technology Data Exchange (ETDEWEB)

    Wuthrick, Evan J., E-mail: evan.wuthrick@osumc.edu [Department of Radiation Oncology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Curran, Walter J. [Department of Radiation Oncology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Camphausen, Kevin [Department of Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland (United States); Lin, Alexander [Department of Radiation Oncology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Glass, Jon; Evans, James; Andrews, David W. [Department of Neurological Surgery, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Axelrod, Rita [Department of Medical Oncology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Shi, Wenyin; Werner-Wasik, Maria [Department of Radiation Oncology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Haacke, E. Mark [Department of Radiology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan (United States); Department of Biomedical Engineering, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan (United States); Hillman, Gilda G. [Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan (United States); Dicker, Adam P. [Department of Radiation Oncology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States)

    2014-10-01

    Purpose/Objective(s): Angiogenic blockade with irradiation may enhance the therapeutic ratio of radiation therapy (RT) through vascular normalization. We sought to determine the safety and toxicity profile of continuous daily-dosed sunitinib when combined with hypofractionated stereotactic RT (fSRT) for recurrent high-grade gliomas (rHGG). Methods and Materials: Eligible patients had malignant high-grade glioma that recurred or progressed after primary surgery and RT. All patients received a minimum of a 10-day course of fSRT, had World Health Organization performance status of 0 to 1, and a life expectancy of >3 months. During fSRT, sunitinib was administered at 37.5 mg daily. The primary endpoint was acute toxicity, and response was assessed via serial magnetic resonance imaging. Results: Eleven patients with rHGG were enrolled. The fSRT doses delivered ranged from 30 to 42 Gy in 2.5- to 3.75-Gy fractions. The median follow-up time was 40 months. Common acute toxicities included hematologic disorders, fatigue, hypertension, and elevated liver transaminases. Sunitinib and fSRT were well tolerated. One grade 4 mucositis toxicity occurred, and no grade 4 or 5 hypertensive events or intracerebral hemorrhages occurred. One patient had a nearly complete response, and 4 patients had stable disease for >9 months. Two patients (18%) remain alive and progression-free >3 years from enrollment. The 6-month progression-free survival was 45%. Conclusions: Sunitinib at a daily dose of 37.5 mg given concurrently with hypofractionated stereotactic reirradiation for rHGG yields acceptable toxicities and an encouraging 6-month progression-free survival.

  17. The study of cultural objects by nuclear and conventional techniques

    International Nuclear Information System (INIS)

    Palacios, Tulio A.

    2000-01-01

    A survey is given of the techniques that are used at the National Atomic Energy Commission of Argentina for the characterization and study of cultural and archaeological specimens. A short history of these activities is also given. (author)

  18. Gefitinib plus cisplatin and radiotherapy in previously untreated head and neck squamous cell carcinoma: A phase II, randomized, double-blind, placebo-controlled study

    International Nuclear Information System (INIS)

    Gregoire, Vincent; Hamoir, Marc; Chen Changhu; Kane, Madeleine; Kawecki, Andrzej; Julka, Pramod K.; Wang, Hung-Ming; Prasad, Srihari; D'Cruz, Anil K.; Radosevic-Jelic, Ljiljana; Kumar, Rejnish R.; Korzeniowski, Stanislaw; Fijuth, Jacek; Machiels, Jean-Pascal; Sellers, Mark V.; Tchakov, Ilian; Raben, David

    2011-01-01

    Background and purpose: To assess the efficacy and safety of gefitinib given concomitantly and/or as maintenance therapy to standard cisplatin/radiotherapy for previously untreated, unresected, stage III/IV non-metastatic SCCHN. Materials and methods: In this phase II, double-blind, study, 226 patients were randomized to gefitinib 250 mg/day, 500 mg/day or placebo in two phases: a concomitant phase (gefitinib or placebo with chemoradiotherapy), followed by a maintenance phase (gefitinib or placebo alone). Primary endpoint was local disease control rate (LDCR) at 2 years; secondary endpoints were LDCR at 1 year, objective response rate, progression-free survival, overall survival, and safety and tolerability. Results: Gefitinib (250 and 500 mg/day) did not improve 2-year LDCR compared with placebo either when given concomitantly with chemoradiotherapy (32.7% vs. 33.6%, respectively; OR 0.921, 95% CI 0.508, 1.670 [1-sided p = 0.607]) or as maintenance therapy (28.8% vs. 37.4%, respectively; OR 0.684, 95% CI 0.377, 1.241 [1-sided p = 0.894]). Secondary efficacy outcomes were broadly consistent with the 2-year LDCR results. In both doses, gefitinib was well-tolerated and did not adversely affect the safety and tolerability of concomitant chemoradiotherapy. Conclusion: Gefitinib was well-tolerated, but did not improve efficacy compared with placebo when given concomitantly with chemoradiotherapy, or as maintenance therapy alone.

  19. Studies in iodine metabolism: 33 year summary, 1948-1979 (as previously submitted) with appendix, 1979-1982

    International Nuclear Information System (INIS)

    Middlesworth, L.V.

    1982-01-01

    The results of research into iodine metabolism from 1948 to 1982 are summarized. Study areas included the monitoring of iodine 131 from fallout in the thyroid glands of cattle and humans, the biological functions and metabolism of thyroid hormones, and methods to reduce the retention of radioiodine in the thyroid

  20. Objectives and Model Payload Definition for NEO Human Mission Studies

    Science.gov (United States)

    Carnelli, I.; Galvez, A.; Carpenter, J.

    2011-10-01

    ESA has supported studies on NEO threat assessment systems and deflection concepts in the context of the General Studies Programme and in close cooperation with the directorates of Technical and Quality Management and of the Scientific Programme. This work has made it possible to identify a project for Europe to make a significant - yet realistic - contribution to the international efforts in this field: the Don Quijote NEO technology demonstration mission. This paper describes what such a small mission can do to prepare future human exploration and what is the in-situ data that can be obtained through such a project.

  1. Objectives and present status of the German risk evaluation study

    International Nuclear Information System (INIS)

    Birkhofer, A.; Koeberlein, K.; Heuser, F.W.

    1977-01-01

    For the German risk evaluation study, analogous to the Rasmussen report (WASH--1400), embarked upon in June 1976, the Kernkraftwerk Biblis B serves as the plant of reference. The first interim results are available for various sub-headings of the study. The main finding seems to be the decisive importance of the containment in limiting the accident consequences even in those cases where, on account of postulated failure of safety systems, the melt down of the reactor core is to be expected. (orig./HP) [de

  2. Objective Measurements in Assessing a Black Music Course of Study.

    Science.gov (United States)

    Taylor, Frederick J.

    1990-01-01

    A study of 80 eighth grade students investigated whether incorporation of a African-American music program would have special benefits for African-American students, music-experienced students, or high-musical-ability students. African-American students, taught material consistent with their heritage, performed better than whites. It is concluded…

  3. Objectives and current status of the study Mobi-kids

    International Nuclear Information System (INIS)

    Cardis, E.; Eastman, C.

    2012-01-01

    The rapid increase in mobile phone use in young people has generated concern about possible health effects of exposure to radiofrequency (RF) fields. Mobi-Kids, an international study coordinated by CREAL Barcelona, is underway in 15 countries to assess potential effects of childhood and adolescent exposure to electromagnetic fields (EMF) from mobile communications technology (RF and extremely low frequency (ELF) fields) on brain tumour risk. The study aims to recruit over 2,000 cases of brain tumours aged 10 to 24 years and their respective controls (300 cases and 600 controls from Spain). The project builds upon the methodological experience of the INTERPHONE study. Hospital based controls are being selected to reduce potential selection bias related to low response rates of population-based controls, validation of questionnaire responses with recross from network operators will allow characterization of possible recall errors. Extensive work has gone into characterising and modelling ELF and RF exposure from different types of mobile and cordless phones, from different communication systems, and from other environmental sources of EMF. The study will address a public health problem of increasing importance in Spain and provide information on potential health risks from mobile telephone use as well as from EMF in general. (Author) 21 refs.

  4. Study on Collaborative Object Manipulation in Virtual Environment

    Science.gov (United States)

    Mayangsari, Maria Niken; Yong-Moo, Kwon

    This paper presents comparative study on network collaboration performance in different immersion. Especially, the relationship between user collaboration performance and degree of immersion provided by the system is addressed and compared based on several experiments. The user tests on our system include several cases: 1) Comparison between non-haptics and haptics collaborative interaction over LAN, 2) Comparison between non-haptics and haptics collaborative interaction over Internet, and 3) Analysis of collaborative interaction between non-immersive and immersive display environments.

  5. Arab Teens Lifestyle Study (ATLS): objectives, design, methodology and implications

    OpenAIRE

    Al-Hazzaa, Hazzaa M; Musaiger, Abdulrahman O

    2011-01-01

    Hazzaa M Al-Hazzaa1,2, Abdulrahman O Musaiger3, ATLS Research Group1Exercise Physiology Laboratory, Department of Physical Education and Movement Sciences, College of Education, King Saud University, 2Scientific Board, Obesity Research Chair, King Saud University, Riyadh, Saudi Arabia; 3Arab Center for Nutrition, Manama, Bahrain, and Nutrition and Health Studies Unit, Deanship of Scientific Research, University of Bahrain, BahrainBackground: There is a lack of comparable data on physical acti...

  6. Publishing studies: the search for an elusive academic object

    Directory of Open Access Journals (Sweden)

    Sophie Noël

    2015-07-01

    Full Text Available This paper questions the validity of the so-called “publishing studies” as an academic discipline, while trying to situate them within the field of social sciences and to contextualize their success. It argues that a more appropriate frame could be adopted to describe what people studying the transformations of book publishing do – or should do – both at a theoretical and methodological level. The paper begins by providing an overview of the scholarly and academic context in France as far as book publishing is concerned, highlighting its genesis and current development. It goes on to underline the main pitfalls that such a sub-field as publishing studies is faced with, before making suggestions as to the bases for a stimulating analysis of publishing, making a case for an interdisciplinary approach nurtured by social sciences. The paper is based on a long-term field study on independent presses in France, together with a survey of literature on the subject.

  7. Structural Study and Evaluation of Previous Restoration Work of Mohammad 'Ali Pasha Mosque at the Citadel in Cairo

    Directory of Open Access Journals (Sweden)

    dr.Yaser Yehya Amin Abdel-Aty

    2011-01-01

    Full Text Available Mohammad 'Ali Pasha Mosque at the Citadel in Cairo is considered one of the main landmarks in Egypt. It majestically stands at a northwestern bend of the Citadel and it is visible from numerous locations in Cairo. It has become the symbol of the Citadel, to the point that its name is given to the whole complex in the colloquial Egyptian parlance. This paper studies analytically the static and dynamic structural behavior of this great mosque using computer numerical modeling techniques, to reach the main reasons for past cracking and failures in its domed-roof and other structural elements, which occurred by the end of 19th Century. A number of 3D-models are analyzed to study the mosque, in both original and after restoration conditions, under static (i.e. dead and live loads and dynamic (i.e. Eigenvector modal analysis, response-spectrum and time-history cases of loading. Besides, structural evaluation of major restoration project, in 1930s, is conducted to determine the current structural safety status of the mosque

  8. Study of stellar objects with strange quark matter crust

    International Nuclear Information System (INIS)

    Hothi, N.; Bisht, S.

    2012-01-01

    The absolute stability of strange quark matter is a viable possibility and immensely effects physics at the astrophysical scale. Relativistic heavy-ion reactions offer a stage to produce this exotic state of matter and the enhanced production of strange particles during these reactions can be studied within the framework of quark-gluon plasma (QGP). We have tried to investigate the role of strangeness under the compact star phenomenology. Emphasis is laid upon the possibility of existence of a third family of strange quark stars and its study help in revealing a number of unexplored features of the cosmos. Bag model parameters have been used to determine some integral parameters for a sequence of strange stars with crust and strange dwarfs constructed out of strange quark matter crust. A comparative analysis is performed between the strange and neutron stars and the strange and white dwarfs based upon these intrinsic parameters and paramount differences are observed. The intimacy between astrophysics and strange quarks depends strongly upon the strange quark matter hypothesis. It states that for a collection of more than a few hundred u, d and s quarks, the energy per baryon E/A of strange quark matter (SQM) can be well below the energy per baryon of the most stable atomic nuclei

  9. Comparative study of a novel application of automated HR HPV assay and stability in a previously untested Preservative media.

    Science.gov (United States)

    Morel, Mike E; McBride, Simon E; Gomez, Maria P

    2017-12-01

    The suitability and stability of cervical cells in Novaprep media (NHQ) for certain HPV assays is unknown. We evaluated the accuracy of an automated HPV assay (Abbott RealTime HR HPV) for cervical cells prepared in NHQ and NHQ with a pre-treatment to mimic a worst case clinical use, compared to the assay manufacturers media; repeatability and reproducibility of HPV results and the stability of detectable HPV in NHQ over time compared to CE marked liquid based cytology preservatives. Cell lines were used to simulate patient samples. Cells stored in NHQ produced accurate, repeatable and reproducible results. Stability in NHQ was comparable to the best performing LBC, with at least 7 months' stability at 18-25°C, 2-8°C, -20°C and -80°C; and at least 3 months' stability at 40°C. Similar results were obtained for pre-treated NHQ except only 3.5 months' stability at 18-25°C. Cell line samples in all media and concentrations tested were detected appropriately by the assay. Based on this first stage validation analytical study, cervical cells stored in NHQ are suitable for the Realtime HPV assay. There should be no reservations for inclusion of NHQ in any further validation and clinical performance evaluation of this assay. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  10. Comparative study of a novel application of automated HR HPV assay and stability in a previously untested Preservative media

    Directory of Open Access Journals (Sweden)

    Mike E. Morel

    2017-12-01

    Full Text Available Background: The suitability and stability of cervical cells in Novaprep media (NHQ for certain HPV assays is unknown. Methods: We evaluated the accuracy of an automated HPV assay (Abbott RealTime HR HPV for cervical cells prepared in NHQ and NHQ with a pre-treatment to mimic a worst case clinical use, compared to the assay manufacturers media; repeatability and reproducibility of HPV results and the stability of detectable HPV in NHQ over time compared to CE marked liquid based cytology preservatives. Cell lines were used to simulate patient samples. Results: Cells stored in NHQ produced accurate, repeatable and reproducible results. Stability in NHQ was comparable to the best performing LBC, with at least 7 months’ stability at 18–25 °C, 2–8 °C, −20 °C and −80 °C; and at least 3 months’ stability at 40 °C. Similar results were obtained for pre-treated NHQ except only 3.5 months’ stability at 18–25 °C. Cell line samples in all media and concentrations tested were detected appropriately by the assay. Conclusions: Based on this first stage validation analytical study, cervical cells stored in NHQ are suitable for the Realtime HPV assay. There should be no reservations for inclusion of NHQ in any further validation and clinical performance evaluation of this assay. Keywords: HPV, Preservative, Sample stability, Automated HR HPV assay

  11. Object permanence in cats (Felis catus): an ecological approach to the study of invisible displacements.

    Science.gov (United States)

    Dumas, C

    1992-12-01

    A single invisible displacement object permanence task was administered to 19 cats (Felis catus). In this task, cats watched a target object from behind a transparent panel. However, cats had to walk around an opaque panel to reach the object. While cats were behind the opaque panel, the object was hidden behind one of two screens. As cats did not perceive the disappearance of the object behind the target screen, the object was invisibly hidden. Results showed that cats solved this task with great flexibility, which markedly contrasts with what has been observed in previous research. The discussion emphasizes the difference between the typical Piagetian task in which the information necessary to succeed must be dealt with in retrospective way, whereas in our task cats had to anticipate a new position of the object. The ecological relevance of this new task is also discussed.

  12. New media as an object of sociological study

    Directory of Open Access Journals (Sweden)

    K. V. Zhurbenko

    2016-06-01

    Full Text Available In the present article the author analyzes the New Media as the factor of the emergence of a fundamentally new culture of communication in modern society. To determine the New Media as a term the author analyzed the interpretations that exist in contemporary sociological literature. Moreover, the author suggests her own definition of «New Media». As a result the author gives methodological research of New and traditional («Old» Media and considers the main benefits of the global network in comparison with traditional media. The author found that there are a number of theoretical concepts to describe the type of society that is transformed under the influence of the mass use of modern communication technologies. The benefit of this study is the research of the social nature of the New Media. Moreover, the author has revealed that New Media technologies have affected even on traditional printed and electronic media, and it led to the formation of new types of social interaction. The author analyzes the key characteristics of the New Media, such as interactivity, individualization, multimedia and the lack of intermediaries. The author researched the key principles of modern communication technologies, which have the greatest impact on the nature of social interaction. Consequently, it was found that New Media can play a key role in political communication. The author found that the political structures, parties and leaders are becoming more active «newsmakers» – the creators of the news. At the same time they become their carriers, which contribute to the conversion of New Media in the factor of transformation of political actor role characteristics. So, the author came to the conclusion that today the relationship between New Media and politics arises because the media are dependent on political information and politicians are directly dependent on the media. The author also analyzed the impact of the Internet and New Media on the process

  13. Study on safety subsidiary objective of nuclear power plant in USA

    International Nuclear Information System (INIS)

    Chen Yan; Zhang Chunming; Fu Zhiwei; Song Wei; Li Chaojun; Wang Zhe; Zuo Jiaxu

    2013-01-01

    This paper reviewed the development of the quantitative safety objective and subsidiary objective in USA. The expressions of CDF and LERF were obtained according to NUREG-1150. The relationship between the subsidiary objective and the quantitative safety objective was derived. The method was compared with that used in NUREG-1860. The requirements of safety objective for the future nuclear power plant and the development of probabilistic safety analysis (PSA) technology in USA were studied and can be used as reference in China. (authors)

  14. Publicly Available Geosynchronous (GEO) Space Object Catalog for Future Space Situational Awareness (SSA) Studies

    Science.gov (United States)

    Koblick, D. C.; Shankar, P.; Xu, S.

    Previously, there have been many commercial proposals and extensive academic studies regarding ground and space based sensors to assist a space surveillance network in obtaining metric observations of satellites and debris near Geosynchronous Earth Orbit (GEO). Most use physics based models for geometric constraints, lighting, and tasker/scheduler operations of sensor architectures. Under similar physics modeling assumptions, the space object catalog is often different due to proprietary standards and datasets. Lack of catalog commonality between studies creates barriers and difficulty comparing performance benefits of sensor trades. To solve this problem, we have constructed a future GEO space catalog from publicly available datasets and literature. The annual number of new payloads and rocket bodies is drawn from a Poisson distribution while the growth of the current GEO catalog is bootstrapped from the historical payload, upper stage, and debris data. We adopt a spherically symmetric explosion model and couple it with the NASA standard breakup model to simulate explosions of payloads and rocket bodies as they are the primary drivers of the debris population growth. The cumulative number of fragments follow a power-law distribution. Result from 1,000 random catalog growth simulations indicates that the GEO space object population in the year 2050 will include over 3,600 objects, nearly half of which are debris greater than 10 cm spherical diameter. The number of rocket bodies and dead payloads is projected to nearly double over the next 33 years. For comparison, the current Air Force Space Command catalog snapshot contains fewer than 50 pieces of debris and coarse Radar Cross Section (RCS) estimates which include: small, medium, and large. The current catalog may be sufficient for conjunction studies, but not for analyzing future sensor system performance. The 2050 GEO projected catalog will be available online for commercial/academic research and development.

  15. Previous ISD Program Review.

    Science.gov (United States)

    1981-03-01

    report. The detail required for such a review would be unwieldy and would comsume inordinate amounts of time. The result of the document review will...attempts have been made at writing specific behavioral objectives (SBOs). These, however, have proven to be inadequate in that they are not stated in... behavioral terms (e.g., "will understand," "will have a knowledge of," etc.). C. Development of CRO/CRTs? In nearly all cases, ISD teams are just

  16. Study of flow over object problems by a nodal discontinuous Galerkin-lattice Boltzmann method

    Science.gov (United States)

    Wu, Jie; Shen, Meng; Liu, Chen

    2018-04-01

    The flow over object problems are studied by a nodal discontinuous Galerkin-lattice Boltzmann method (NDG-LBM) in this work. Different from the standard lattice Boltzmann method, the current method applies the nodal discontinuous Galerkin method into the streaming process in LBM to solve the resultant pure convection equation, in which the spatial discretization is completed on unstructured grids and the low-storage explicit Runge-Kutta scheme is used for time marching. The present method then overcomes the disadvantage of standard LBM for depending on the uniform meshes. Moreover, the collision process in the LBM is completed by using the multiple-relaxation-time scheme. After the validation of the NDG-LBM by simulating the lid-driven cavity flow, the simulations of flows over a fixed circular cylinder, a stationary airfoil and rotating-stationary cylinders are performed. Good agreement of present results with previous results is achieved, which indicates that the current NDG-LBM is accurate and effective for flow over object problems.

  17. Risk perception, experience, and objective risk: a cross-national study with European emergency survivors.

    Science.gov (United States)

    Knuth, Daniela; Kehl, Doris; Hulse, Lynn; Schmidt, Silke

    2014-07-01

    Understanding public risk perceptions and their underlying processes is important in order to learn more about the way people interpret and respond to hazardous emergency events. Direct experience with an involuntary hazard has been found to heighten the perceived risk of experiencing the same hazard and its consequences in the future, but it remains unclear if cross-over effects are possible (i.e., experience with one hazard influencing perceived risk for other hazards also). Furthermore, the impact of objective risk and country of residence on perceived risk is not well understood. As part of the BeSeCu (Behavior, Security, and Culture) Project, a sample of 1,045 survivors of emergencies from seven European countries (i.e., Germany, the Czech Republic, Poland, Sweden, Spain, Turkey, and Italy) was drawn. Results revealed heightened perceived risk for emergency events (i.e., domestic and public fires, earthquakes, floods, and terrorist attacks) when the event had been experienced previously plus some evidence of cross-over effects, although these effects were not so strong. The largest country differences in perceived risk were observed for earthquakes, but this effect was significantly reduced by taking into account the objective earthquake risk. For fires, floods, terrorist attacks, and traffic accidents, only small country differences in perceived risk were found. Further studies including a larger number of countries are welcomed. © 2013 Society for Risk Analysis.

  18. Thoughts on Improvable Objects, Contradiction and Object/Tool Reciprocity in a Study of Zoo Educator Professional Development

    Science.gov (United States)

    Ash, Doris B.; Kelly, Lisa-Anne DeGregoria

    2013-01-01

    In this forum we discuss three aspects designed to clarify and extend Kelly and Kassing's paper. These are the roles of improvable objects, contradiction and object/tool reciprocity. In each case we cite relevant literature and pose questions to the field. Our goal is to seed ideas for future discussions concerning the role of activity theory…

  19. A Case Study of Resources Management Planning with Multiple Objectives and Projects

    Science.gov (United States)

    David L. Peterson; David G. Silsbee; Daniel L. Schmoldt

    1995-01-01

    Each National Park Service unit in the United States produces a resources management plan (RMP) every four years or less. The plans commit budgets and personnel to specific projects for four years, but they are prepared with little quantitative and analytical rigor and without formal decisionmaking tools. We have previously described a multiple objective planning...

  20. Polychlorinated biphenyl exposure, diabetes and endogenous hormones: a cross-sectional study in men previously employed at a capacitor manufacturing plant.

    Science.gov (United States)

    Persky, Victoria; Piorkowski, Julie; Turyk, Mary; Freels, Sally; Chatterton, Robert; Dimos, John; Bradlow, H Leon; Chary, Lin Kaatz; Burse, Virlyn; Unterman, Terry; Sepkovic, Daniel W; McCann, Kenneth

    2012-08-29

    Studies have shown associations of diabetes and endogenous hormones with exposure to a wide variety of organochlorines. We have previously reported positive associations of polychlorinated biphenyls (PCBs) and inverse associations of selected steroid hormones with diabetes in postmenopausal women previously employed in a capacitor manufacturing plant. This paper examines associations of PCBs with diabetes and endogenous hormones in 63 men previously employed at the same plant who in 1996 underwent surveys of their exposure and medical history and collection of bloods and urine for measurements of PCBs, lipids, liver function, hematologic markers and endogenous hormones. PCB exposure was positively associated with diabetes and age and inversely associated with thyroid stimulating hormone and triiodothyronine-uptake. History of diabetes was significantly related to total PCBs and all PCB functional groupings, but not to quarters worked and job score, after control for potential confounders. None of the exposures were related to insulin resistance (HOMA-IR) in non-diabetic men. Associations of PCBs with specific endogenous hormones differ in some respects from previous findings in postmenopausal women employed at the capacitor plant. Results from this study, however, do confirm previous reports relating PCB exposure to diabetes and suggest that these associations are not mediated by measured endogenous hormones.

  1. Objective Cognitive Impairment and Progression to Dementia in Women: The Prospective Epidemiological Risk Factor Study

    DEFF Research Database (Denmark)

    Neergaard, Jesper; Dragsbæk, K.; Christiansen, C.

    2017-01-01

    Background: Identification of subjects with a progressive disease phenotype is an urgent need in the pharmaceutical industry where most of the recent clinical trials in Alzheimer’s disease have failed. Objectives: The objective of this study was to identify subgroups of individuals with objective...

  2. Quantifying the influence of previously burned areas on suppression effectiveness and avoided exposure: A case study of the Las Conchas Fire

    Science.gov (United States)

    Matthew P. Thompson; Patrick Freeborn; Jon D. Rieck; Dave Calkin; Julie W. Gilbertson-Day; Mark A. Cochrane; Michael S. Hand

    2016-01-01

    We present a case study of the Las Conchas Fire (2011) to explore the role of previously burned areas (wildfires and prescribed fires) on suppression effectiveness and avoided exposure. Methodological innovations include characterisation of the joint dynamics of fire growth and suppression activities, development of a fire line effectiveness framework, and...

  3. Study of some physical aspects previous to design of an exponential experiment; Estudio de algunos aspectos fisicos previos al diseno de una experiencia exponencial

    Energy Technology Data Exchange (ETDEWEB)

    Caro, R; Francisco, J L. de

    1961-07-01

    This report presents the theoretical study of some physical aspects previous to the design of an exponential facility. The are: Fast and slow flux distribution in the multiplicative medium and in the thermal column, slowing down in the thermal column, geometrical distribution and minimum needed intensity of sources access channels and perturbations produced by possible variations in its position and intensity. (Author) 4 refs.

  4. A Spectroscopic Study of Young Stellar Objects in the Serpens Cloud Core and NGC 1333

    Science.gov (United States)

    Winston, E.; Megeath, S. T.; Wolk, S. J.; Hernandez, J.; Gutermuth, R.; Muzerolle, J.; Hora, J. L.; Covey, K.; Allen, L. E.; Spitzbart, B.; Peterson, D.; Myers, P.; Fazio, G. G.

    2009-06-01

    We present spectral observations of 130 young stellar objects (YSOs) in the Serpens Cloud Core and NGC 1333 embedded clusters. The observations consist of near-IR spectra in the H and K bands from SpeX on the IRTF and far-red spectra (6000-9000 Å) from Hectospec on the Multi-Mirror Telescope. These YSOs were identified in previous Spitzer and Chandra observations, and the evolutionary classes of the YSOs were determined from the Spitzer mid-IR photometry. With these spectra we search for corroborating evidence for the pre-main-sequence nature of the objects, study the properties of the detected emission lines as a function of evolutionary class, and obtain spectral types for the observed YSOs. The temperatures implied by the spectral types are combined with luminosities determined from the near-IR photometry to construct Hertzsprung-Russell (H-R) diagrams for the clusters. By comparing the positions of the YSOs in the H-R diagrams with the pre-main-sequence tracks of Baraffe (1998), we determine the ages of the embedded sources and study the relative ages of the YSOs with and without optically thick circumstellar disks. The apparent isochronal ages of the YSOs in both clusters range from less than 1 Myr to 10 Myr, with most objects below 3 Myr. The observed distributions of ages for the Class II and Class III objects are statistically indistinguishable. We examine the spatial distribution and extinction of the YSOs as a function of their isochronal ages. We find the sources dispersed and are not deeply embedded. Nonetheless, the sources with isochronal ages >3 Myr show all the characteristics of YSOs in their spectra, their IR spectral energy distributions, and their X-ray emission; we find no evidence that they are contaminating background giants or foreground dwarfs. However, we find no corresponding decrease in the fraction of sources with infrared excess with isochronal age; this suggests that the older isochronal ages may not measure the true age of the >3

  5. A cross-sectional study of tuberculosis drug resistance among previously treated patients in a tertiary hospital in Accra, Ghana: public health implications of standardized regimens.

    Science.gov (United States)

    Forson, Audrey; Kwara, Awewura; Kudzawu, Samuel; Omari, Michael; Otu, Jacob; Gehre, Florian; de Jong, Bouke; Antonio, Martin

    2018-04-02

    Mycobacterium tuberculosis drug resistance is a major challenge to the use of standardized regimens for tuberculosis (TB) therapy, especially among previously treated patients. We aimed to investigate the frequency and pattern of drug resistance among previously treated patients with smear-positive pulmonary tuberculosis at the Korle-Bu Teaching Hospital Chest Clinic, Accra. This was a cross-sectional survey of mycobacterial isolates from previously treated patients referred to the Chest Clinic Laboratory between October 2010 and October 2013. The Bactec MGIT 960 system for mycobactrerial culture and drug sensitivity testing (DST) was used for sputum culture of AFB smear-positive patients with relapse, treatment failure, failure of smear conversion, or default. Descriptive statistics were used to summarize patient characteristics, and frequency and patterns of drug resistance. A total of 112 isolates were studied out of 155 from previously treated patients. Twenty contaminated (12.9%) and 23 non-viable isolates (14.8%) were excluded. Of the 112 studied isolates, 53 (47.3%) were pan-sensitive to all first-line drugs tested Any resistance (mono and poly resistance) to isoniazid was found in 44 isolates (39.3%) and any resistance to streptomycin in 43 (38.4%). Thirty-one (27.7%) were MDR-TB. Eleven (35.5%) out of 31 MDR-TB isolates were pre-XDR. MDR-TB isolates were more likely than non-MDR isolates to have streptomycin and ethambutol resistance. The main findings of this study were the high prevalence of MDR-TB and streptomycin resistance among previously treated TB patients, as well as a high prevalence of pre-XDR-TB among the MDR-TB patients, which suggest that first-line and second-line DST is essential to aid the design of effective regimens for these groups of patients in Ghana.

  6. Study on hybrid multi-objective optimization algorithm for inverse treatment planning of radiation therapy

    International Nuclear Information System (INIS)

    Li Guoli; Song Gang; Wu Yican

    2007-01-01

    Inverse treatment planning for radiation therapy is a multi-objective optimization process. The hybrid multi-objective optimization algorithm is studied by combining the simulated annealing(SA) and genetic algorithm(GA). Test functions are used to analyze the efficiency of algorithms. The hybrid multi-objective optimization SA algorithm, which displacement is based on the evolutionary strategy of GA: crossover and mutation, is implemented in inverse planning of external beam radiation therapy by using two kinds of objective functions, namely the average dose distribution based and the hybrid dose-volume constraints based objective functions. The test calculations demonstrate that excellent converge speed can be achieved. (authors)

  7. Development of novel tasks for studying view-invariant object recognition in rodents: Sensitivity to scopolamine.

    Science.gov (United States)

    Mitchnick, Krista A; Wideman, Cassidy E; Huff, Andrew E; Palmer, Daniel; McNaughton, Bruce L; Winters, Boyer D

    2018-05-15

    The capacity to recognize objects from different view-points or angles, referred to as view-invariance, is an essential process that humans engage in daily. Currently, the ability to investigate the neurobiological underpinnings of this phenomenon is limited, as few ethologically valid view-invariant object recognition tasks exist for rodents. Here, we report two complementary, novel view-invariant object recognition tasks in which rodents physically interact with three-dimensional objects. Prior to experimentation, rats and mice were given extensive experience with a set of 'pre-exposure' objects. In a variant of the spontaneous object recognition task, novelty preference for pre-exposed or new objects was assessed at various angles of rotation (45°, 90° or 180°); unlike control rodents, for whom the objects were novel, rats and mice tested with pre-exposed objects did not discriminate between rotated and un-rotated objects in the choice phase, indicating substantial view-invariant object recognition. Secondly, using automated operant touchscreen chambers, rats were tested on pre-exposed or novel objects in a pairwise discrimination task, where the rewarded stimulus (S+) was rotated (180°) once rats had reached acquisition criterion; rats tested with pre-exposed objects re-acquired the pairwise discrimination following S+ rotation more effectively than those tested with new objects. Systemic scopolamine impaired performance on both tasks, suggesting involvement of acetylcholine at muscarinic receptors in view-invariant object processing. These tasks present novel means of studying the behavioral and neural bases of view-invariant object recognition in rodents. Copyright © 2018 Elsevier B.V. All rights reserved.

  8. Is email a reliable means of contacting authors of previously published papers? A study of the Emergency Medicine Journal for 2001.

    Science.gov (United States)

    O'Leary, F

    2003-07-01

    To determine whether it is possible to contact authors of previously published papers via email. A cross sectional study of the Emergency Medicine Journal for 2001. 118 articles were included in the study. The response rate from those with valid email addresses was 73%. There was no statistical difference between the type of email address used and the address being invalid (p=0.392) or between the type of article and the likelihood of a reply (p=0.197). More responses were obtained from work addresses when compared with Hotmail addresses (86% v 57%, p=0.02). Email is a valid means of contacting authors of previously published articles, particularly within the emergency medicine specialty. A work based email address may be a more valid means of contact than a Hotmail address.

  9. The study of subjective and objective evaluation of sleep disturbances in Parkinson's disease

    Directory of Open Access Journals (Sweden)

    LIU Chun-feng

    2013-08-01

    Full Text Available Background Sleep disorder is one of the most common non-motor symptoms in Parkinson's disease (PD patients. At present, there are subjective and objective tools to evaluate sleepdisorders. Nevertheless, previous studies commonly used single subjective questionnaires or objective examinations. Therefore, we used the combinations of subjective and objective tools to analyze clinical characteristics of sleep disturbances in PD and investigated differences and consistence between subjective and objective tools. Methods One hundred and sixteen PD patients were eligible to participate into this study. All participants were evaluated by Pittsburgh Sleep Quality Index (PSQI, Unified Parkinson's Disease Rating Scale (UPDRS in "on" condition, Hoehn-Yahr (H-Y stage, Hamilton Depression Rating Scale (HAMD 24 items, Montreal Cognitive Assessment (MoCA, Epworth Sleepiness Scale (ESS, and underwent a video-polysomnography (Video-PSG. Results According to PSQI score of 116 PD patients, the proportion of PD patients with sleep disturbances (PSQI ≥ 7 was 50% (N = 58. Compared to PD patients without sleep disturbances, PD patients with sleep disturbances had lower score of MoCA (23.34 ± 3.50 vs 24.89 ± 3.52; t = 2.377, P = 0.019, higher score of UPDRSⅠ[4.00 (2.00, 5.00 vs 3.00 (2.00, 5.00; U = - 2.306, P = 0.021], UPDRSⅡ[12.00 (9.00, 16.00 vs 10.00 (6.00, 13.00; U = - 1.995, P = 0.046], higher levodopa equivalent daily dose [LED, (508.14 ± 335.85 vs (394.06 ± 236.40 mg/d; t = - 2.115, P = 0.037]. Although PD patients with sleep disturbances had more score of UPDSR Ⅲ and higher H-Y stage, the differences were not significant (P > 0.05. On the other hand, decreased total sleep time (TST, reduced sleep efficiency (SE, increased sleep latency (SL, decreased non-rapid eye movement (NREM sleep stage Ⅱ time were found for PD patients with sleep disturbances (P 0.05, for all. The score of PSQI was positively correlated with the score of ESS (r = 0.200, P = 0

  10. Earthquake Damage Assessment Using Objective Image Segmentation: A Case Study of 2010 Haiti Earthquake

    Science.gov (United States)

    Oommen, Thomas; Rebbapragada, Umaa; Cerminaro, Daniel

    2012-01-01

    In this study, we perform a case study on imagery from the Haiti earthquake that evaluates a novel object-based approach for characterizing earthquake induced surface effects of liquefaction against a traditional pixel based change technique. Our technique, which combines object-oriented change detection with discriminant/categorical functions, shows the power of distinguishing earthquake-induced surface effects from changes in buildings using the object properties concavity, convexity, orthogonality and rectangularity. Our results suggest that object-based analysis holds promise in automatically extracting earthquake-induced damages from high-resolution aerial/satellite imagery.

  11. Previous dropout from diabetic care as a predictor of patients' willingness to use mobile applications for self-management: A cross-sectional study.

    Science.gov (United States)

    Yamaguchi, Satoko; Waki, Kayo; Tomizawa, Nobuko; Waki, Hironori; Nannya, Yasuhito; Nangaku, Masaomi; Kadowaki, Takashi; Ohe, Kazuhiko

    2017-07-01

    Preventing dropout is crucial in managing diabetes. Accordingly, we investigated whether patients who had dropped out of diabetic care are suitable candidates for the use of mobile technologies - such as smartphone applications - to support self-management (mHealth), which might help prevent dropout. We carried out a cross-sectional study in Tokyo, Japan. Patients aged 20 years or older who were clinically diagnosed as diabetic and who regularly visited the outpatient unit at the University of Tokyo Hospital were recruited between August 2014 and March 2015. Data were collected through face-to-face structured interviews, physical measurements and medical records. Participants were asked whether they were willing to use mHealth after being shown DialBetics - an mHealth application for diabetics - as an example, and about their history of dropout and previous mHealth experience. Data were analyzed by multivariate logistic regression models. Of 307 patients with type 1 and type 2 diabetes, 34 (11.1%) had previously dropped out from diabetic care. Multivariate analysis identified previous mHealth experience as a negative predictor of dropout (odds ratio 0.211, P = 0.023). Of those 34 patients, 27 (79.4%) expressed willingness to use mHealth, a significantly higher percentage than for those who had never dropped out (51.5%, P = 0.002). After adjusting for confounders, history of dropout remained a strong predictor of willingness (odds ratio 3.870, P = 0.004). Patients who previously dropped out of diabetic care are suitable candidates for mHealth. Future studies must evaluate whether mHealth is effective for preventing repeated dropout and improving glycemic control among this population. © 2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

  12. Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: a nationwide study

    DEFF Research Database (Denmark)

    Schramm, Tina Ken; Gislason, Gunnar Hilmar; Vaag, Allan

    2011-01-01

    Aims The impact of insulin secretagogues (ISs) on long-term major clinical outcomes in type 2 diabetes remains unclear. We examined mortality and cardiovascular risk associated with all available ISs compared with metformin in a nationwide study. Methods and results All Danish residents >20 years......, initiating single-agent ISs or metformin between 1997 and 2006 were followed for up to 9 years (median 3.3 years) by individual-level linkage of nationwide registers. All-cause mortality, cardiovascular mortality, and the composite of myocardial infarction (MI), stroke, and cardiovascular mortality...... associated with individual ISs were investigated in patients with or without previous MI by multivariable Cox proportional-hazard analyses including propensity analyses. A total of 107 806 subjects were included, of whom 9607 had previous MI. Compared with metformin, glimepiride (hazard ratios and 95...

  13. Developing Canadian oncology education goals and objectives for medical students: a national modified Delphi study.

    Science.gov (United States)

    Tam, Vincent C; Ingledew, Paris-Ann; Berry, Scott; Verma, Sunil; Giuliani, Meredith E

    2016-01-01

    Studies have shown that there is a deficiency in focused oncology teaching during medical school in Canada. This study aimed to develop oncology education goals and objectives for medical students through consensus of oncology educators from across Canada. In 2014 we created a comprehensive list of oncology education objectives using existing resources. Experts in oncology education and undergraduate medical education from all 17 Canadian medical schools were invited to participate in a 3-round modified Delphi process. In round 1, the participants scored the objectives on a 9-point Likert scale according to the degree to which they agreed an objective should be taught to medical students. Objectives with a mean score of 7.0 or greater were retained, those with a mean score of 1.0-3.9 were excluded, and those with a mean score of 4.0-6.9 were discussed at a round 2 Web meeting. In round 3, the participants voted on inclusion and exclusion of the round 2 objectives. Thirty-four (92%) of the 37 invited oncology educators, representing 14 medical schools, participated in the study. They included oncologists, family physicians, members of undergraduate medical education curriculum committees and a psychologist. Of the 214 objectives reviewed in round 1, 146 received a mean score of 7.0 or greater, and 68 were scored 4.0-6.9; no objective received a mean score below 4.0. Nine new objectives were suggested. The main themes of participants' comments were to minimize the number of objectives and to aim objectives at the knowledge level required for family physicians. In round 2, the participants were able to combine 28 of the objectives with other existing objectives. In round 3, 7 of the 49 objectives received consensus of at least 75% for inclusion. The final Canadian Oncology Goals and Objectives for Medical Students contained 10 goals and 153 objectives. Through a systematic process, we created a comprehensive, consensus-based set of oncology goals and objectives to

  14. Portraits of PBL: Course Objectives and Students' Study Strategies in Computer Engineering, Psychology and Physiotherapy.

    Science.gov (United States)

    Dahlgren, Madeleine Abrandt

    2000-01-01

    Compares the role of course objectives in relation to students' study strategies in problem-based learning (PBL). Results comprise data from three PBL programs at Linkopings University (Sweden), in physiotherapy, psychology, and computer engineering. Faculty provided course objectives to function as supportive structures and guides for students'…

  15. Object-Location Memory: A Lesion-Behavior Mapping Study in Stroke Patients

    Science.gov (United States)

    van Asselen, Marieke; Kessels, Roy P. C.; Frijns, Catharina J. M.; Kappelle, L. Jaap; Neggers, Sebastiaan F. W.; Postma, Albert

    2009-01-01

    Object-location memory is an important form of spatial memory, comprising different subcomponents that each process specific types of information within memory, i.e. remembering objects, remembering positions and binding these features in memory. In the current study we investigated the neural correlates of binding categorical (relative) or…

  16. Acceleration and Orientation Jumping Performance Differences Among Elite Professional Male Handball Players With or Without Previous ACL Reconstruction: An Inertial Sensor Unit-Based Study.

    Science.gov (United States)

    Setuain, Igor; González-Izal, Miriam; Alfaro, Jesús; Gorostiaga, Esteban; Izquierdo, Mikel

    2015-12-01

    Handball is one of the most challenging sports for the knee joint. Persistent biomechanical and jumping capacity alterations can be observed in athletes with an anterior cruciate ligament (ACL) injury. Commonly identified jumping biomechanical alterations have been described by the use of laboratory technologies. However, portable and easy-to-handle technologies that enable an evaluation of jumping biomechanics at the training field are lacking. To analyze unilateral/bilateral acceleration and orientation jumping performance differences among elite male handball athletes with or without previous ACL reconstruction via a single inertial sensor unit device. Case control descriptive study. At the athletes' usual training court. Twenty-two elite male (6 ACL-reconstructed and 16 uninjured control players) handball players were evaluated. The participants performed a vertical jump test battery that included a 50-cm vertical bilateral drop jump, a 20-cm vertical unilateral drop jump, and vertical unilateral countermovement jump maneuvers. Peak 3-dimensional (X, Y, Z) acceleration (m·s(-2)), jump phase duration and 3-dimensional orientation values (°) were obtained from the inertial sensor unit device. Two-tailed t-tests and a one-way analysis of variance were performed to compare means. The P value cut-off for significance was set at P handball athletes with previous ACL reconstruction demonstrated a jumping biomechanical profile similar to control players, including similar jumping performance values in both bilateral and unilateral jumping maneuvers, several years after ACL reconstruction. These findings are in agreement with previous research showing full functional restoration of abilities in top-level male athletes after ACL reconstruction, rehabilitation and subsequent return to sports at the previous level. Copyright © 2015 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

  17. The Netherlands XTC Toxicity (NeXT) study: objectives and methods of a study investigating causality, course, and clinical relevance.

    Science.gov (United States)

    De Win, Maartje M L; Jager, Gerry; Vervaeke, Hylke K E; Schilt, Thelma; Reneman, Liesbeth; Booij, Jan; Verhulst, Frank C; Den Heeten, Gerard J; Ramsey, Nick F; Korf, Dirk J; Van den Brink, Wim

    2005-01-01

    This paper describes the objectives and methods of The Netherlands XTC Toxicity (NeXT) study focussing on the causality, course, and clinical relevance of ecstasy neurotoxicity. Previous studies suggest that ecstasy (3,4 methylene-dioxymethamphetamine, MDMA, XTC) is toxic toward brain serotonin axons, but most of these studies have serious methodological limitations. The current study is a combination of different approaches with three substudies: (1) a crosssectional substudy among heavy ecstasy users and controls with variation in drug use, which will provide information about potential neurotoxic consequences of ecstasy in relation to other drugs; (2) a prospective cohort substudy in ecstasy-naive subjects with high risk for future ecstasy use, which will provide information on the causality and short-term course of ecstasy use and potential neurotoxicity, and (3) a retrospective cohort substudy in lifetime ecstasy users and matched controls of an existing epidemiological sample that will provide information on long-term course and outcome of ecstasy use in the general population. Neurotoxicity is studied using (a) different imaging techniques (beta-CIT SPECT, 1H-MR spectroscopy, diffusion tensor imaging, perfusion weighted imaging and functional magnetic resonance imaging), and (b) neuropsychological and psychiatric assessments of memory, depression, and personality. The combined results will lead to conclusions that can be used in prevention messages, clinical decision making, and the development of an (inter)national ecstasy policy.

  18. De novo adamantinomatous craniopharyngioma presenting anew in an elderly patient with previous normal CT and MRI studies: A case report and implications on pathogenesis

    Directory of Open Access Journals (Sweden)

    Amy Walker, B.S.

    2015-09-01

    Full Text Available Adamantinomatous craniopharyngiomas are histologically benign epithelial tumors which arise from embryonic remnants of the craniopharyngeal duct and Rathke’s pouch. They are thought to have a congenital origin and are histologically unique from papillary craniopharyngioma. We describe the case of an elderly male who presented with symptoms related to a large craniopharyngioma with previously normal brain magnetic resonance and computed tomography imaging studies. These findings dispute the embryogenic theory that craniopharyngiomas observed in adults develop from the persistent slow growth of embryonic remnants.

  19. Impact of Availability and Use of ART/PMTCT Services on Fertility Desires of Previously Pregnant Women in Rakai, Uganda: A Retrospective Cohort Study.

    Science.gov (United States)

    Litwin, Lindsay E; Makumbi, Frederick E; Gray, Ronald; Wawer, Maria; Kigozi, Godfrey; Kagaayi, Joseph; Nakigozi, Gertrude; Lutalo, Tom; Serwada, David; Brahmbhatt, Heena

    2015-07-01

    To assess fertility desires by availability and use of antiretroviral therapy and prevention of mother-to-child transmission (ART/PMTCT) services in Rakai, Uganda. Retrospective analyses of longitudinal data from the Rakai Community Cohort Study. Study participants were retrospectively identified and categorized by HIV status. Availability of ART/PMTCT services in Rakai was defined in three periods: (1) pre-ART/PMTCT (ART/PMTCT rollout (2005-2006), and (3) universal ART/PMTCT (>2006); and use of ART/PMTCT was coded as yes if the woman received services. Trends in fertility desires were assessed by χ. "Modified" Poisson regression was performed using generalized linear models with a log link and Poisson family to estimate prevalence rate ratios (PRRs) and 95% confidence intervals (CIs) of desire for another child among previously and currently pregnant women; PRRs were adjusted for demographic and behavioral factors. A total of 4227 sexually active women in Rakai, including 436 HIV+ women, contributed 13,970 observations over 5 survey rounds. Fertility desires increased in the population in the ART/PMTCT rollout [adjusted (adj.) PRR: 1.08, 95% CI: 1.04 to 1.13] and the universal availability periods (adj. PRR: 1.11, 95% CI: 1.08 to 1.14) compared with pre-ART/PMTCT period. A total of 862 woman observations used ART/PMTCT services. Fertility desires were similar among ART/PMTCT service users and nonusers in cross-sectional analysis (adj. PRR: 0.84, 95% CI: 0.62 to 1.14) and 1 year after ART/PMTCT use (adj. PRR: 1.27, 95% CI: 0.83 to 1.94). Availability of ART/PMTCT may increase fertility desires of previously pregnant women in Rakai, Uganda. Use of ART/PMTCT services was not correlated with fertility desires of previously or current pregnant women.

  20. Geometrical accuracy of metallic objects produced with additive or subtractive manufacturing: A comparative in vitro study.

    Science.gov (United States)

    Braian, Michael; Jönsson, David; Kevci, Mir; Wennerberg, Ann

    2018-04-06

    To evaluate the accuracy and precision of objects produced by additive manufacturing systems (AM) for use in dentistry and to compare with subtractive manufacturing systems (SM). Ten specimens of two geometrical objects were produced by five different AM machines and one SM machine. Object A mimics an inlay-shaped object, while object B imitates a four-unit bridge model. All the objects were sorted into different measurement dimensions (x, y, z), linear distances, angles and corner radius. None of the additive manufacturing or subtractive manufacturing groups presented a perfect match to the CAD file with regard to all parameters included in the present study. Considering linear measurements, the precision for subtractive manufacturing group was consistent in all axes for object A, presenting results of additive manufacturing groups had consistent precision in the x-axis and y-axis but not in the z-axis. With regard to corner radius measurements, the SM group had the best overall accuracy and precision for both objects A and B when compared to the AM groups. Within the limitations of this in vitro study, the conclusion can be made that subtractive manufacturing presented overall precision on all measurements below 0.050mm. The AM machines also presented fairly good precision, additive techniques are now being implemented. Thus all these production techniques need to be tested, compared and validated. Copyright © 2018 The Academy of Dental Materials. Published by Elsevier Inc. All rights reserved.

  1. Outcome of secondary high-grade glioma in children previously treated for a malignant condition: A study of the Canadian Pediatric Brain Tumour Consortium

    International Nuclear Information System (INIS)

    Carret, Anne-Sophie; Tabori, Uri; Crooks, Bruce; Hukin, Juliette; Odame, Isaac; Johnston, Donna L.; Keene, Daniel L.; Freeman, Carolyn; Bouffet, Eric

    2006-01-01

    Background and purpose: Reports of secondary high-grade glioma (HGG) in survivors of childhood cancer are scarce. The aim of this study was to review the pattern of diagnosis, the treatment, and outcome of secondary pediatric HGG. Patients and methods: We performed a multi-center retrospective study among the 17 paediatric institutions participating in the Canadian Pediatric Brain Tumour Consortium (CPBTC). Results: We report on 18 patients (14 males, 4 females) treated in childhood for a primary cancer, who subsequently developed a HGG as a second malignancy. All patients had previously received radiation therapy +/- chemotherapy for either acute lymphoblastic leukaemia (n = 9) or solid tumour (n = 9). All HGG occurred within the previous radiation fields. At the last follow-up, 17 patients have died and the median survival time is 9.75 months. Conclusion: Although aggressive treatment seems to provide sustained remissions in some patients, the optimal management is still to be defined. Further documentation of such cases is necessary in order to better understand the pathogenesis, the natural history and the prevention of these tumours

  2. Values Education as Perceived by Social Studies Teachers in Objective and Practice Dimensions

    Science.gov (United States)

    Katilmis, Ahmet

    2017-01-01

    The purpose of this study was to reveal the objectives of values education in Turkey, values education-related activities performed in schools, and preferred approaches to values education according to the opinions of social studies teachers. This qualitative study used a phenomenological pattern. The participants of the study were selected from…

  3. Landscape heritage objects' effect on driving: a combined driving simulator and questionnaire study.

    Science.gov (United States)

    Antonson, Hans; Ahlström, Christer; Mårdh, Selina; Blomqvist, Göran; Wiklund, Mats

    2014-01-01

    According to the literature, landscape (panoramas, heritage objects e.g. landmarks) affects people in various ways. Data are primarily developed by asking people (interviews, photo sessions, focus groups) about their preferences, but to a lesser degree by measuring how the body reacts to such objects. Personal experience while driving a car through a landscape is even more rare. In this paper we study how different types of objects in the landscape affect drivers during their drive. A high-fidelity moving-base driving simulator was used to measure choice of speed and lateral position in combination with stress (heart rate measure) and eye tracking. The data were supplemented with questionnaires. Eighteen test drivers (8 men and 10 women) with a mean age of 37 were recruited. The test drivers were exposed to different new and old types of landscape objects such as 19th century church, wind turbine, 17th century milestone and bus stop, placed at different distances from the road driven. The findings are in some respect contradictory, but it was concluded that that 33% of the test drivers felt stressed during the drive. All test drivers said that they had felt calm at times during the drive but the reason for this was only to a minor degree connected with old and modern objects. The open landscape was experienced as conducive to acceleration. Most objects were, to a small degree, experienced (subjective data) as having a speed-reducing effect, much in line with the simulator data (objective data). Objects close to the road affected the drivers' choice of' lateral position. No significant differences could be observed concerning the test drivers' gaze between old or modern objects, but a significant difference was observed between the test drivers' gaze between road stretches with faraway objects and stretches without objects. No meaningful, significant differences were found for the drivers' stress levels as measured by heart rate. Copyright © 2013 Elsevier Ltd. All

  4. A long-term controlled follow-up study of objective treatment need on young adults treated with functional appliances.

    Science.gov (United States)

    Faxén Sepanian, Varoojan; Paulsson-Björnsson, Liselotte; Kjellberg, Heidrun

    2014-01-01

    The aims of this study were to 1) evaluate the objective success rate of Class II malocclusion treatment with functional appliances five years after completion of treatment and 2) to compare the remaining objective treatment need with an untreated control group. Records of all listed patients between 18-20 years (n=1054) treated in a general practice were reviewed for the purpose of finding treatments with removable functional appliances. Among all subjects (n=61) who previously had been treated, 58 accepted to participate in the study.The test group was matched with an orthodontically untreated group with no history of objective treatment need. Clinical examination was performed and study casts and photos were taken from both groups.The objective treatment need was evaluated through clinical examination and study cast analysis with weighted Peer Assessment Rating index (wPAR). Twenty patients, (34.5%) (mean wPAR 13.8), succeeded with the functional appliance treatment.The wPAR score (mean 15.0) of the entire test group was significantly higher than the one of the control group (mean 7.3).The group that was treated exclusively with functional appliances had a mean wPAR score of 17.4. Eighteen patients (31.0%) who received retreatment with fixed appliances had a slightly higher mean wPAR (8.6) than the control group. Treatments with functional appliances in a general practice showed a high failure rate and a remaining treatment need. It is the treating dentist's responsibility to motivate the patient to cooperate to the treatment, because as it previously has been shown the treatment with functional appliances is a well-functioning treatment alternative with the cooperation of the patient being sufficient. It is also of importance, already before starting treatment, to estimate the child's cooperation ability and to avoid treatment with removable appliances if the child or parents are reluctant about such a treatment.

  5. Implementation of minimally invasive and objective humane endpoints in the study of murine Plasmodium infections

    DEFF Research Database (Denmark)

    Dellavalle, B; Kirchhoff, J; Maretty, L

    2014-01-01

    SUMMARY Defining appropriate and objective endpoints for animal research can be difficult. Previously we evaluated and implemented a body temperature (BT) of ECM) and were interested in a similar endpoint for a model of severe malarial...... anaemia (SMA). Furthermore, we investigate the potential of a minimally invasive, non-contact infrared thermometer for repeated BT measurement. ECM was induced with Plasmodium berghei ANKA infection in C57Bl/6 mice. SMA was induced with Plasmodium chabaudi AS infection in A/J mice. Our previous published...... endpoint was applied in ECM and 30 °C was pre-determined as the lowest permitted limit for termination in SMA according to consultation with the Danish Animal Inspectorate. Infrared thermometer was compared with the rectal probe after cervical dislocation, ECM and SMA. Linear regression analysis of rectal...

  6. Studying visual attention using the multiple object tracking paradigm: A tutorial review.

    Science.gov (United States)

    Meyerhoff, Hauke S; Papenmeier, Frank; Huff, Markus

    2017-07-01

    Human observers are capable of tracking multiple objects among identical distractors based only on their spatiotemporal information. Since the first report of this ability in the seminal work of Pylyshyn and Storm (1988, Spatial Vision, 3, 179-197), multiple object tracking has attracted many researchers. A reason for this is that it is commonly argued that the attentional processes studied with the multiple object paradigm apparently match the attentional processing during real-world tasks such as driving or team sports. We argue that multiple object tracking provides a good mean to study the broader topic of continuous and dynamic visual attention. Indeed, several (partially contradicting) theories of attentive tracking have been proposed within the almost 30 years since its first report, and a large body of research has been conducted to test these theories. With regard to the richness and diversity of this literature, the aim of this tutorial review is to provide researchers who are new in the field of multiple object tracking with an overview over the multiple object tracking paradigm, its basic manipulations, as well as links to other paradigms investigating visual attention and working memory. Further, we aim at reviewing current theories of tracking as well as their empirical evidence. Finally, we review the state of the art in the most prominent research fields of multiple object tracking and how this research has helped to understand visual attention in dynamic settings.

  7. A case study of resources management planning with multiple objectives and projects

    Science.gov (United States)

    Peterson, David L.; Silsbee, David G.; Schmoldt, Daniel L.

    1994-09-01

    Each National Park Service unit in the United States produces a resources management plan (RMP) every four years or less. The plans commit budgets and personnel to specific projects for four years, but they are prepared with little quantitative and analytical rigor and without formal decision-making tools. We have previously described a multiple objective planning process for inventory and monitoring programs (Schmoldt and others 1994). To test the applicability of that process for the more general needs of resources management planning, we conducted an exercise on the Olympic National Park (NP) in Washington State, USA. Eight projects were selected as typical of those considered in RMPs and five members of the Olympic NP staff used the analytic hierarchy process (AHP) to prioritize the eight projects with respect to their implicit management objectives. By altering management priorities for the park, three scenarios were generated. All three contained some similarities in rankings for the eight projects, as well as some differences. Mathematical allocations of money and people differed among these scenarios and differed substantially from what the actual 1990 Olympic NP RMP contains. Combining subjective priority measures with budget dollars and personnel time into an objective function creates a subjective economic metric for comparing different RMP’s. By applying this planning procedure, actual expenditures of budget and personnel in Olympic NP can agree more closely with the staff’s management objectives for the park.

  8. A multi-objective set covering problem: A case study of warehouse allocation in truck industry

    Directory of Open Access Journals (Sweden)

    Atefeh Malekinezhad

    2011-01-01

    Full Text Available Designing distribution centers is normally formulated in a form of set covering where is primary objective is to minimize the number of connected facilities. However, there are other issues affecting our decision on selecting suitable distribution centers such as weather conditions, temperature, infrastructure facilities, etc. In this paper, we propose a multi-objective set covering techniques where different objectives are considered in an integrated model. The proposed model of this paper is implemented for a real-world case study of truck-industry and the results are analyzed.

  9. Plantar pressure in diabetic peripheral neuropathy patients with active foot ulceration, previous ulceration and no history of ulceration: a meta-analysis of observational studies.

    Science.gov (United States)

    Fernando, Malindu Eranga; Crowther, Robert George; Pappas, Elise; Lazzarini, Peter Anthony; Cunningham, Margaret; Sangla, Kunwarjit Singh; Buttner, Petra; Golledge, Jonathan

    2014-01-01

    Elevated dynamic plantar pressures are a consistent finding in diabetes patients with peripheral neuropathy with implications for plantar foot ulceration. This meta-analysis aimed to compare the plantar pressures of diabetes patients that had peripheral neuropathy and those with neuropathy with active or previous foot ulcers. Published articles were identified from Medline via OVID, CINAHL, SCOPUS, INFORMIT, Cochrane Central EMBASE via OVID and Web of Science via ISI Web of Knowledge bibliographic databases. Observational studies reporting barefoot dynamic plantar pressure in adults with diabetic peripheral neuropathy, where at least one group had a history of plantar foot ulcers were included. Interventional studies, shod plantar pressure studies and studies not published in English were excluded. Overall mean peak plantar pressure (MPP) and pressure time integral (PTI) were primary outcomes. The six secondary outcomes were MPP and PTI at the rear foot, mid foot and fore foot. The protocol of the meta-analysis was published with PROPSERO, (registration number CRD42013004310). Eight observational studies were included. Overall MPP and PTI were greater in diabetic peripheral neuropathy patients with foot ulceration compared to those without ulceration (standardised mean difference 0.551, 95% CI 0.290-0.811, pdiabetic peripheral neuropathy with a history of foot ulceration compared to those with diabetic neuropathy without a history of ulceration. More homogenous data is needed to confirm these findings.

  10. Studies of Ancient Russian Cultural Objects Using the Neutron Tomography Method

    Directory of Open Access Journals (Sweden)

    Sergey Kichanov

    2018-01-01

    Full Text Available Neutron radiography and tomography is a non-destructive method that provides detailed information about the internal structure of cultural heritage objects. The differences in the neutron attenuation coefficients of constituent elements of the studied objects, as well as the application of modern mathematical algorithms to carry out three-dimensional imaging data analysis, allow one to obtain unique information about the spatial distribution of different phases, the presence of internal defects, or the degree of structural degradation inside valuable cultural objects. The results of the neutron studies of several archaeological objects related to different epochs of the Russian history are reported in order to demonstrate the opportunities provided by the neutron tomography method. The obtained 3D structural volume data, as well as the results of the corresponding data analysis, are presented.

  11. Phase II study of a 3-day schedule with topotecan and cisplatin in patients with previously untreated small cell lung cancer and extensive disease

    DEFF Research Database (Denmark)

    Sorensen, M.; Lassen, Ulrik Niels; Jensen, Peter Buhl

    2008-01-01

    INTRODUCTION: Treatment with a topoisomerase I inhibitor in combination with a platinum results in superior or equal survival compared with etoposide-based treatment in extensive disease small cell lung cancer (SCLC). Five-day topotecan is inconvenient and therefore shorter schedules of topotecan...... and cisplatin are needed. The aim of this phase II study was to establish the response rate and response duration in chemo-naive patients with SCLC receiving a 3-day topotecan and cisplatin schedule. METHODS: Simons optimal two-stage design was used. Patients with previously untreated extensive disease SCLC...... age was 59 (range 44-74), 79% had performance status 0 or 1. Thirty-one patients completed all six cycles. Grade 3/4 anemia, neutrocytopenia, and thrombocytopenia were recorded in 9.5%, 66.7%, and 21.4% of patients, respectively. Fourteen percent of patients experienced neutropenic fever. No episodes...

  12. Selective attention affects conceptual object priming and recognition: A study with young and older adults

    OpenAIRE

    Soledad eBallesteros; Julia eMayas

    2015-01-01

    In the present study, we investigated the effects of selective attention at encoding on conceptual object priming (Experiment 1) and old–new recognition memory (Experiment 2) tasks in young and older adults. The procedures of both experiments included encoding and memory test phases separated by a short delay. At encoding, the picture outlines of two familiar objects, one in blue and the other in green, were presented to the left and to the right of fixation. In Experiment 1, participants wer...

  13. EXPERIMENTAL CHALLENGE STUDY OF FV3-LIKE RANAVIRUS INFECTION IN PREVIOUSLY FV3-LIKE RANAVIRUS INFECTED EASTERN BOX TURTLES (TERRAPENE CAROLINA CAROLINA) TO ASSESS INFECTION AND SURVIVAL.

    Science.gov (United States)

    Hausmann, Jennifer C; Wack, Allison N; Allender, Matthew C; Cranfield, Mike R; Murphy, Kevin J; Barrett, Kevin; Romero, Jennell L; Wellehan, James F X; Blum, Stella A; Zink, M Christine; Bronson, Ellen

    2015-12-01

    The Maryland Zoo in Baltimore experienced an outbreak of Frog virus-3 (FV3)-like ranavirus during the summer of 2011, during which 14 of 27 (52%) of its captive eastern box turtles (Terrapene carolina carolina) survived. To assess survival, immunity, and viral shedding, an experimental challenge study was performed in which the surviving, previously infected turtles were reinfected with the outbreak strain of FV3-like ranavirus. Seven turtles were inoculated with virus intramuscularly and four control turtles received saline intramuscularly. The turtles were monitored for 8 wk with blood and oral swabs collected for quantitative polymerase chain reaction (qPCR). During that time, one of seven (14%) inoculated turtles and none of the controls (0%) died; there was no significant difference in survival. Clinical signs of the inoculated turtles, except for the turtle that died, were mild compared to the original outbreak. Quantitative PCR for FV3-like ranavirus on blood and oral swabs was positive for all inoculated turtles and negative for all controls. The turtle that died had intracytoplasmic inclusion bodies in multiple organs. Three inoculated and two control turtles were euthanized at the end of the study. No inclusion bodies were present in any of the organs. Quantitative PCR detected FV3-like ranavirus in the spleen of a control turtle, which suggested persistence of the virus. The surviving five turtles were qPCR-negative for FV3-like ranavirus from blood and oral swabs after brumation. Quantitative PCR for Terrapene herpesvirus 1 found no association between ranavirus infection and herpesvirus loads. In conclusion, previously infected eastern box turtles can be reinfected with the same strain of FV3-like ranavirus and show mild to no clinical signs but can shed the virus from the oral cavity.

  14. Biomarker-driven trial in metastatic pancreas cancer: feasibility in a multicenter study of saracatinib, an oral Src inhibitor, in previously treated pancreatic cancer

    International Nuclear Information System (INIS)

    Arcaroli, John; Quackenbush, Kevin; Dasari, Arvind; Powell, Rebecca; McManus, Martine; Tan, Aik-Choon; Foster, Nathan R; Picus, Joel; Wright, John; Nallapareddy, Sujatha; Erlichman, Charles; Hidalgo, Manuel; Messersmith, Wells A

    2012-01-01

    Src tyrosine kinases are overexpressed in pancreatic cancers, and the oral Src inhibitor saracatinib has shown antitumor activity in preclinical models of pancreas cancer. We performed a CTEP-sponsored Phase II clinical trial of saracatinib in previously treated pancreas cancer patients, with a primary endpoint of 6-month survival. A Simon MinMax two-stage phase II design was used. Saracatinib (175 mg/day) was administered orally continuously in 28-day cycles. In the unselected portion of the study, 18 patients were evaluable. Only two (11%) patients survived for at least 6 months, and three 6-month survivors were required to move to second stage of study as originally designed. The study was amended as a biomarker-driven trial (leucine rich repeat containing protein 19 [LRRC19] > insulin-like growth factor-binding protein 2 [IGFBP2] “top scoring pairs” polymerase chain reaction [PCR] assay, and PIK3CA mutant) based on preclinical data in a human pancreas tumor explant model. In the biomarker study, archival tumor tissue or fresh tumor biopsies were tested. Biomarker-positive patients were eligible for the study. Only one patient was PIK3CA mutant in a 3′ untranslated region (UTR) portion of the gene. This patient was enrolled in the study and failed to meet the 6-month survival endpoint. As the frequency of biomarker-positive patients was very low (<3%), the study was closed. Although we were unable to conclude whether enriching for a subset of second/third line pancreatic cancer patients treated with a Src inhibitor based on a biomarker would improve 6-month survival, we demonstrate that testing pancreatic tumor samples for a biomarker-driven, multicenter study in metastatic pancreas cancer is feasible

  15. Determination of the object surface function by structured light: application to the study of spinal deformities

    International Nuclear Information System (INIS)

    Buendia, M.; Salvador, R.; Cibrian, R.; Sotoca, J.M.; Laguia, M.

    1999-01-01

    The projection of structured light is a technique frequently used to determine the surface shape of an object. In this paper, a new procedure is described that efficiently resolves the correspondence between the knots of the projected grid and those obtained on the object when the projection is made. The method is based on the use of three images of the projected grid. In two of them the grid is projected over a flat surface placed, respectively, before and behind the object; both images are used for calibration. In the third image the grid is projected over the object. It is not reliant on accurate determination of the camera and projector pair relative to the grid and object. Once the method is calibrated, we can obtain the surface function by just analysing the projected grid on the object. The procedure is especially suitable for the study of objects without discontinuities or large depth gradients. It can be employed for determining, in a non-invasive way, the patient's back surface function. Symmetry differences permit a quantitative diagnosis of spinal deformities such as scoliosis. (author)

  16. A study on software-based sensing technology for multiple object control in AR video.

    Science.gov (United States)

    Jung, Sungmo; Song, Jae-Gu; Hwang, Dae-Joon; Ahn, Jae Young; Kim, Seoksoo

    2010-01-01

    Researches on Augmented Reality (AR) have recently received attention. With these, the Machine-to-Machine (M2M) market has started to be active and there are numerous efforts to apply this to real life in all sectors of society. To date, the M2M market has applied the existing marker-based AR technology in entertainment, business and other industries. With the existing marker-based AR technology, a designated object can only be loaded on the screen from one marker and a marker has to be added to load on the screen the same object again. This situation creates a problem where the relevant marker'should be extracted and printed in screen so that loading of the multiple objects is enabled. However, since the distance between markers will not be measured in the process of detecting and copying markers, the markers can be overlapped and thus the objects would not be augmented. To solve this problem, a circle having the longest radius needs to be created from a focal point of a marker to be copied, so that no object is copied within the confines of the circle. In this paper, software-based sensing technology for multiple object detection and loading using PPHT has been developed and overlapping marker control according to multiple object control has been studied using the Bresenham and Mean Shift algorithms.

  17. A Study on Software-based Sensing Technology for Multiple Object Control in AR Video

    Directory of Open Access Journals (Sweden)

    Seoksoo Kim

    2010-11-01

    Full Text Available Researches on Augmented Reality (AR have recently received attention. With these, the Machine-to-Machine (M2M market has started to be active and there are numerous efforts to apply this to real life in all sectors of society. To date, the M2M market has applied the existing marker-based AR technology in entertainment, business and other industries. With the existing marker-based AR technology, a designated object can only be loaded on the screen from one marker and a marker has to be added to load on the screen the same object again. This situation creates a problem where the relevant marker should be extracted and printed in screen so that loading of the multiple objects is enabled. However, since the distance between markers will not be measured in the process of detecting and copying markers, the markers can be overlapped and thus the objects would not be augmented. To solve this problem, a circle having the longest radius needs to be created from a focal point of a marker to be copied, so that no object is copied within the confines of the circle. In this paper, software-based sensing technology for multiple object detection and loading using PPHT has been developed and overlapping marker control according to multiple object control has been studied using the Bresenham and Mean Shift algorithms.

  18. Women's decision-making processes and the influences on their mode of birth following a previous caesarean section in Taiwan: a qualitative study.

    Science.gov (United States)

    Chen, Shu-Wen; Hutchinson, Alison M; Nagle, Cate; Bucknall, Tracey K

    2018-01-17

    Vaginal birth after caesarean (VBAC) is an alternative option for women who have had a previous caesarean section (CS); however, uptake is limited because of concern about the risks of uterine rupture. The aim of this study was to explore women's decision-making processes and the influences on their mode of birth following a previous CS. A qualitative approach was used. The research comprised three stages. Stage I consisted of naturalistic observation at 33-34 weeks' gestation. Stage II involved interviews with pregnant women at 35-37 weeks' gestation. Stage III consisted of interviews with the same women who were interviewed postnatally, 1 month after birth. The research was conducted in a private medical centre in northern Taiwan. Using a purposive sampling, 21 women and 9 obstetricians were recruited. Data collection involved in-depth interviews, observation and field notes. Constant comparative analysis was employed for data analysis. Ensuring the safety of mother and baby was the focus of women's decisions. Women's decisions-making influences included previous birth experience, concern about the risks of vaginal birth, evaluation of mode of birth, current pregnancy situation, information resources and health insurance. In communicating with obstetricians, some women complied with obstetricians' recommendations for repeat caesarean section (RCS) without being informed of alternatives. Others used four step decision-making processes that included searching for information, listening to obstetricians' professional judgement, evaluating alternatives, and making a decision regarding mode of birth. After birth, women reflected on their decisions in three aspects: reflection on birth choices; reflection on factors influencing decisions; and reflection on outcomes of decisions. The health and wellbeing of mother and baby were the major concerns for women. In response to the decision-making influences, women's interactions with obstetricians regarding birth choices

  19. The Efficacy and Safety of Icotinib in Patients with Advanced Non-Small Cell Lung Cancer Previously Treated with Chemotherapy: A Single-Arm, Multi-Center, Prospective Study.

    Directory of Open Access Journals (Sweden)

    Xingsheng Hu

    Full Text Available Icotinib is a small molecule targeting epidermal growth factor receptor tyrosine kinase, which shows non-inferior efficacy and better safety comparing to gefitinib in previous phase III trial. The present study was designed to further evaluate the efficacy and safety of icotinib in patients with advanced non-small-cell lung cancer (NSCLC previously treated with platinum-based chemotherapy.Patients with NSCLC progressing after one or two lines of chemotherapy were enrolled to receive oral icotinib (125 mg tablet, three times per day. The primary endpoint was progression-free survival. The secondary endpoints included overall survival, objective response rate, time to progression, quality of life and safety.From March 16, 2010 to October 9, 2011, 128 patients from 15 centers nationwide were enrolled, in which 124 patients were available for efficacy evaluation and 127 patients were evaluable for safety. The median progression-free survival and time to progression were 5.0 months (95%CI 2.9-6.6 m and 5.4 months (95%CI 3.1-7.9 m, respectively. The objective response rate and disease control rate were 25.8% and 67.7% respectively. Median overall survival exceeded 17.6 months (95%CI 14.2 m-NA according to censored data. Further follow-up of overall survival is ongoing. The most frequent treatment-related adverse events were rash (26%, 33/127, diarrhea (12.6%, 16/127 and elevation of transaminase (15.7%, 20/127.In general, this study showed similar efficacy and numerically better safety when compared with that in ICOGEN trial, further confirming the efficacy and safety of icotinib in treating patients with advanced NSCLC previously treated with chemotherapy.ClinicalTrials.gov NCT02486354.

  20. The Efficacy and Safety of Icotinib in Patients with Advanced Non-Small Cell Lung Cancer Previously Treated with Chemotherapy: A Single-Arm, Multi-Center, Prospective Study.

    Science.gov (United States)

    Hu, Xingsheng; Zhang, Li; Shi, Yuankai; Zhou, Caicun; Liu, Xiaoqing; Wang, Dong; Song, Yong; Li, Qiang; Feng, Jifeng; Qin, Shukui; Xv, Nong; Zhou, Jianying; Zhang, Li; Hu, Chunhong; Zhang, Shucai; Luo, Rongcheng; Wang, Jie; Tan, Fenlai; Wang, Yinxiang; Ding, Lieming; Sun, Yan

    2015-01-01

    Icotinib is a small molecule targeting epidermal growth factor receptor tyrosine kinase, which shows non-inferior efficacy and better safety comparing to gefitinib in previous phase III trial. The present study was designed to further evaluate the efficacy and safety of icotinib in patients with advanced non-small-cell lung cancer (NSCLC) previously treated with platinum-based chemotherapy. Patients with NSCLC progressing after one or two lines of chemotherapy were enrolled to receive oral icotinib (125 mg tablet, three times per day). The primary endpoint was progression-free survival. The secondary endpoints included overall survival, objective response rate, time to progression, quality of life and safety. From March 16, 2010 to October 9, 2011, 128 patients from 15 centers nationwide were enrolled, in which 124 patients were available for efficacy evaluation and 127 patients were evaluable for safety. The median progression-free survival and time to progression were 5.0 months (95%CI 2.9-6.6 m) and 5.4 months (95%CI 3.1-7.9 m), respectively. The objective response rate and disease control rate were 25.8% and 67.7% respectively. Median overall survival exceeded 17.6 months (95%CI 14.2 m-NA) according to censored data. Further follow-up of overall survival is ongoing. The most frequent treatment-related adverse events were rash (26%, 33/127), diarrhea (12.6%, 16/127) and elevation of transaminase (15.7%, 20/127). In general, this study showed similar efficacy and numerically better safety when compared with that in ICOGEN trial, further confirming the efficacy and safety of icotinib in treating patients with advanced NSCLC previously treated with chemotherapy. ClinicalTrials.gov NCT02486354.

  1. Left posterior BA37 is involved in object recognition: a TMS study

    DEFF Research Database (Denmark)

    Stewart, Lauren; Meyer, Bernd-Ulrich; Frith, Uta

    2001-01-01

    Functional imaging studies have proposed a role for left BA37 in phonological retrieval, semantic processing, face processing and object recognition. The present study targeted the posterior aspect of BA37 to see whether a deficit, specific to one of the above types of processing could be induced...... to name pictures when TMS was given over lBA37 compared to vertex or rBA37. rTMS over lBA37 had no significant effect on word reading, nonword reading or colour naming. The picture naming deficit is suggested to result from a disruption to object recognition processes. This study corroborates the finding...... from a recent imaging study, that the most posterior part of left hemispheric BA37 has a necessary role in object recognition....

  2. Notes on English used as a lingua franca as an object of study

    DEFF Research Database (Denmark)

    Mortensen, Janus

    2013-01-01

    This article discusses how English used as a lingua franca (ELF) can be defined as an object of study. It offers a critical appraisal of a high-profile definition of ELF (the VOICE/Seidlhofer definition), and argues that definitions of this kind, whether purposely or not, in effect invite...... approach to the conceptualization of ELF where ELF is defined in straightforward functional terms as the use of English in a lingua franca language scenario. This definition underscores the complexity and breadth of ELF as an object of study, and highlights that researchers in the field of ELF studies need...

  3. Studies on combined model based on functional objectives of large scale complex engineering

    Science.gov (United States)

    Yuting, Wang; Jingchun, Feng; Jiabao, Sun

    2018-03-01

    As various functions were included in large scale complex engineering, and each function would be conducted with completion of one or more projects, combined projects affecting their functions should be located. Based on the types of project portfolio, the relationship of projects and their functional objectives were analyzed. On that premise, portfolio projects-technics based on their functional objectives were introduced, then we studied and raised the principles of portfolio projects-technics based on the functional objectives of projects. In addition, The processes of combined projects were also constructed. With the help of portfolio projects-technics based on the functional objectives of projects, our research findings laid a good foundation for management of large scale complex engineering portfolio management.

  4. The development of object function and manipulation knowledge: evidence from a semantic priming study

    Directory of Open Access Journals (Sweden)

    Cynthia Collette

    2016-08-01

    Full Text Available Object semantics include object function and manipulation knowledge. Function knowledge refers to the goal attainable by using an object (e.g. the function of a key is to open or close a door while manipulation knowledge refers to gestures one has to execute to use an object appropriately (e.g. a key is held between the thumb and the index, inserted into the door lock and then turned.To date, several studies have assessed function and manipulation knowledge in brain lesion patients as well as in healthy adult populations. In patients with left brain damage, a double dissociation between these two types of knowledge has been reported; on the other hand, behavioral studies in healthy adults show that function knowledge is processed faster than manipulation knowledge. Empirical evidence has shown that object interaction in children differs from that in adults, suggesting that the access to function and manipulation knowledge in children might also differ.To investigate the development of object function and manipulation knowledge, 51 typically developing 8-9-10 year-old children and 17 healthy young adults were tested on a naming task associated with a semantic priming paradigm (190-ms SOA; prime duration: 90 ms in which a series of line drawings of manipulable objects were used. Target objects could be preceded by three priming contexts: related (e.g. knife-scissors for function; key-screwdriver for manipulation, unrelated but visually similar (e.g. glasses-scissors; baseball bat-screwdriver, and purely unrelated (e.g. die-scissors; tissue-screwdriver.Results showed a different developmental pattern of function and manipulation priming effects. Function priming effects were not present in children and emerged only in adults, with faster naming responses for targets preceded by objects sharing the same function. In contrast, manipulation priming effects were already present in 8-year-olds with faster naming responses for targets preceded by objects

  5. Four Forensic Entomology Case Studies: Records and Behavioral Observations on Seldom Reported Cadaver Fauna With Notes on Relevant Previous Occurrences and Ecology.

    Science.gov (United States)

    Lindgren, Natalie K; Sisson, Melissa S; Archambeault, Alan D; Rahlwes, Brent C; Willett, James R; Bucheli, Sibyl R

    2015-03-01

    A yearlong survey of insect taxa associated with human decomposition was conducted at the Southeast Texas Applied Forensic Science (STAFS) facility located in the Center for Biological Field Studies of Sam Houston State University in Huntsville, TX. During this study, four insect-cadaver interactions were observed that represent previously poorly documented yet forensically significant interactions: Syrphidae maggots colonized a corpse in an aquatic situation; Psychodidae adults mated and oviposited on an algal film that was present on a corpse that had been recently removed from water; several Panorpidae were the first insects to feed upon a freshly placed corpse in the autumn; and a noctuid caterpillar was found chewing and ingesting dried human skin. Baseline knowledge of insect-cadaver interactions is the foundation of forensic entomology, and unique observations have the potential to expand our understanding of decomposition ecology. © The Author 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  6. Objectively determined habitual physical activity in South African adolescents: the PAHL study

    Science.gov (United States)

    2014-01-01

    Background There is limited data on objectively determined habitual physical activity (PA) in 16-year old South African adolescents. The purpose of this study was to objectively determine the habitual PA of adolescents from the North West Province of South Africa by race and gender. Methods Adolescents (137 girls, 89 boys) from the ongoing Physical Activity and Health Longitudinal Study (PAHL study), participated in the present study. Habitual PA was objectively recorded by means of the Actiheart® over a period of 7 days. Time spent in moderate-to-vigorous intensity physical activity (MVPA) was assessed. Results Average MVPA for the study sample was 50.9 ± 40.3 minutes/day. Girls were significantly more active than boys expending more time in MVPA (61.13 ± 52.2 minutes/day; p Physical activity varies by both gender and race in adolescents from the North West Province of South Africa. Objectively determined data from our study indicates that girls habitually spend more time in MVPA per day than boys, and that white adolescents habitually engage in more MVPA than black adolescents. Seeing as the average MVPA per day for the entire study sample falls below the recommended daily average of 60minutes/day, adolescents should be the foremost targets of interventions aimed at enhancing habitual PA. PMID:24885503

  7. Say it with flowers! An fMRI study of object mediated communication

    DEFF Research Database (Denmark)

    Tylén, Kristian; Wallentin, Mikkel; Roepstorff, Andreas

    2009-01-01

    Human communicational interaction can be mediated by a host of expressive means from words in a natural language to gestures and material symbols. Given the proper contextual setting even an everyday object can gain a mediating function in a communicational situation. In this study we used event......-related fMRI to study the brain activity caused by everyday material objects when they are perceived as signals. We found that comprehension of material signals activates bilaterally areas of the ventral stream and pars triangularis of the inferior frontal cortex, that is, areas traditionally associated...

  8. Late tamoxifen in patients previously operated for breast cancer without postoperative tamoxifen: 5-year results of a single institution randomised study

    International Nuclear Information System (INIS)

    Veronesi, Andrea; Miolo, GianMaria; Magri, Maria D; Crivellari, Diana; Scalone, Simona; Bidoli, Ettore; Lombardi, Davide

    2010-01-01

    A population of breast cancer patients exists who, for various reasons, never received adjuvant post-operative tamoxifen (TAM). This study was aimed to evaluate the role of late TAM in these patients. From 1997 to 2003, patients aged 35 to 75 years, operated more than 2 years previously for monolateral breast cancer without adjuvant TAM, with no signs of metastases and no contraindication to TAM were randomized to TAM 20 mg/day orally for 2 years or follow-up alone. Events were categorized as locoregional relapse, distant metastases, metachronous breast cancer, tumours other than breast cancer and death from any causes, whichever occurred first. The sample size (197 patients per arm, plus 10% allowance) was based on the assumption of a 30% decrease in the number of events occurring at a rate of 5% annually in the 10 years following randomization. Four hundred and thirty-three patients were randomized in the study (TAM 217, follow-up 216). Patients characteristics (TAM/follow-up) included: median age 55/55 years, median time from surgery 25/25 months (range, 25-288/25-294), in situ carcinoma 18/24, oestrogen receptor (ER) positive in 75/68, negative in 70/57, unknown in 72/91 patients. Previous adjuvant treatment included chemotherapy in 131/120 and an LHRH analogue in 11/13 patients. Thirty-six patients prematurely discontinued TAM after a median of 1 month, mostly because of subjective intolerance. Eighty-three events (TAM 39, follow-up 44) occurred: locoregional relapse in 10/8, distant metastases in 14/16, metachronous breast cancer in 4/10, other tumours in 11/10 patients. Less ER-positive secondary breast cancers occurred in the TAM treated patients than in follow-up patients (1 vs 10, p = 0.005). Event-free survival was similar in both groups of patients. This 5-year analysis revealed significantly less metachronous ER-positive breast cancers in the TAM treated patients. No other statistically significant differences have emerged thus far

  9. Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Prevented Weight Regain in Obese Women with Polycystic Ovary Syndrome Previously Treated with Liraglutide: A Pilot Randomized Study.

    Science.gov (United States)

    Ferjan, Simona; Janez, Andrej; Jensterle, Mojca

    2017-12-01

    Weight loss is often nonsustainable after liraglutide cessation. The present study is the first insight into the potential prevention of weight regain in obese subjects who have been withdrawn from liraglutide. We evaluated whether dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin in adjunct to metformin prevents body weight regain more effectively than metformin alone in obese polycystic ovary syndrome (PCOS) previously treated with liraglutide. A 12-week prospective randomized open-label study was conducted with 24 obese women with PCOS who had been pretreated with liraglutide 3.0 mg due to antiobesity management (aged 34.3 ± 6.8 years, body mass index [BMI] 36.3 ± 5.2 kg/m 2 , mean ± standard deviation). They were randomized to combined treatment (COMBO) with sitagliptin 100 mg per day (QD) and metformin (MET) 1000 mg twice daily (BID) (n = 12) or MET 1000 mg BID (n = 12). Lifestyle intervention was promoted in both groups. The primary outcome was change in anthropometric measures of obesity. Women treated with MET regain 4.7 ± 2.7 kg (P = 0.002) compared with a 0.9 ± 2.5 kg in COMBO (P = 0.147). BMI increased for 1.7 ± 0.9 kg/m 2 in MET (P = 0.002) compared with 0.3 ± 0.8 kg/m 2 increase in COMBO (P = 0.136). MET group regain 4.5% ± 2.5% of body weight as opposed to 0.8% ± 2.6% in COMBO. The between-treatment differences were significant for weight change (P weight change (P weight regain in obese women with PCOS previously treated with liraglutide.

  10. Study on Transient Properties of Levitated Object in Near-Field Acoustic Levitation

    Science.gov (United States)

    Jia, Bing; Chen, Chao; Zhao, Chun-Sheng

    2011-12-01

    A new approach to the study on the transient properties of the levitated object in near-field acoustic levitation (NFAL) is presented. In this article, the transient response characteristics, including the levitated height of an object with radius of 24 mm and thickness of 5 mm, the radial velocity and pressure difference of gas at the boundary of clearance between the levitated object and radiating surface (squeeze film), is calculated according to several velocity amplitudes of radiating surface. First, the basic equations in fluid areas on Arbitrary Lagrange—Euler (ALE) form are numerically solved by using streamline upwind petrov galerkin (SUPG) finite elements method. Second, the formed algebraic equations and solid control equations are solved by using synchronous alternating method to gain the transient messages of the levitated object and gas in the squeeze film. Through theoretical and numerical analyses, it is found that there is a oscillation time in the transient process and that the response time does not simply increase with the increasing of velocity amplitudes of radiating surface. More investigations in this paper are helpful for the understanding of the transient properties of levitated object in NFAL, which are in favor of enhancing stabilities and responsiveness of levitated object.

  11. Study on Transient Properties of Levitated Object in Near-Field Acoustic Levitation

    International Nuclear Information System (INIS)

    Jia Bing; Chen Chao; Zhao Chunsheng

    2011-01-01

    A new approach to the study on the transient properties of the levitated object in near-field acoustic levitation (NFAL) is presented. In this article, the transient response characteristics, including the levitated height of an object with radius of 24 mm and thickness of 5 mm, the radial velocity and pressure difference of gas at the boundary of clearance between the levitated object and radiating surface (squeeze film), is calculated according to several velocity amplitudes of radiating surface. First, the basic equations in fluid areas on Arbitrary Lagrange-Euler (ALE) form are numerically solved by using streamline upwind petrov galerkin (SUPG) finite elements method. Second, the formed algebraic equations and solid control equations are solved by using synchronous alternating method to gain the transient messages of the levitated object and gas in the squeeze film. Through theoretical and numerical analyses, it is found that there is a oscillation time in the transient process and that the response time does not simply increase with the increasing of velocity amplitudes of radiating surface. More investigations in this paper are helpful for the understanding of the transient properties of levitated object in NFAL, which are in favor of enhancing stabilities and responsiveness of levitated object. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  12. Spontaneous object recognition: a promising approach to the comparative study of memory

    Directory of Open Access Journals (Sweden)

    Rachel eBlaser

    2015-07-01

    Full Text Available Spontaneous recognition of a novel object is a popular measure of exploratory behavior, perception and recognition memory in rodent models. Because of its relative simplicity and speed of testing, the variety of stimuli that can be used, and its ecological validity across species, it is also an attractive task for comparative research. To date, variants of this test have been used with vertebrate and invertebrate species, but the methods have seldom been sufficiently standardized to allow cross-species comparison. Here, we review the methods necessary for the study of novel object recognition in mammalian and non-mammalian models, as well as the results of these experiments. Critical to the use of this test is an understanding of the organism’s initial response to a novel object, the modulation of exploration by context, and species differences in object perception and exploratory behaviors. We argue that with appropriate consideration of species differences in perception, object affordances, and natural exploratory behaviors, the spontaneous object recognition test can be a valid and versatile tool for translational research with non-mammalian models.

  13. A comparison of subjective and objective measures of physical activity from the Newcastle 85+ study.

    Science.gov (United States)

    Innerd, Paul; Catt, Michael; Collerton, Joanna; Davies, Karen; Trenell, Michael; Kirkwood, Thomas B L; Jagger, Carol

    2015-07-01

    Little is known about physical activity (PA) in the very old, the fastest growing age group in the population. We aimed to examine the convergent validity of subjective and objective measures of PA in adults aged over 85 years. A total of 484 participants aged 87-89 years recruited to the Newcastle 85+ study completed a purpose-designed physical activity questionnaire (PAQ), which categorised participants as mildly active, moderately active and very active. Out of them, 337 participants wore a triaxial, raw accelerometer on the right wrist over a 5-7-day period to obtain objective measures of rest/activity, PA intensity and PA type. Data from subjective and objective measurement methods were compared. Self-reported PA was significantly associated with objective measures of the daily sedentary time, low-intensity PA and activity type classified as sedentary, activities of daily living and walking. Objective measures of PA were significantly different when low, moderate and high self-reported PA categories were compared (all P PAQ demonstrated convergent validity with objective measures of PA. Our findings suggest that this PAQ can be used in the very old to rank individuals according to their level of total PA. © The Author 2015. Published by Oxford University Press on behalf of the British Geriatrics Society.

  14. Art, historical and cultural heritage objects studied with different non-destructive analysis

    International Nuclear Information System (INIS)

    Rizzutto, Marcia A.; Tabacniks, Manfredo H.; Added, Nemitala; Campos, Pedro H.O.V.; Curado, Jessica F.; Kajiya, Elizabeth A.M.

    2012-01-01

    Full text: Since 2003, the analysis of art, historical and cultural heritage objects has being performed at the Laboratorio de Analise de Materiais of the Instituto de Fisica of the Universidade de Sao Paulo (LAMFI-USP). Initially the studies were restricted to non-destructive methods using ion beams to characterize the chemical elements present in the objects. Recently, new analytical techniques and procedures have been incorporated to the better characterization of the objects and the examinations were expanded to other non-destructive analytical techniques such as portable X-Ray fluorescence (XRF), digitalized radiography, high resolution photography with visible, UV (ultraviolet) light and reflectography in the infrared region. These non-destructive analytical techniques systematically applied to the objects are helping the better understanding of these objects and allow studying them by examining their main components; their conservation status and also the creative process of the artist, particularly in easel paintings allow making new discoveries. The setup of the external beam in the LAMFI laboratory is configured to allow different simultaneous analysis by PIXE / PIGE (Particle Induced X-ray emission / Particle Induced gamma rays emission), RBS (Rutherford Backscattering) and IBL (Ion Beam Luminescence) and to expand the archaeometric results using ion beams. PIXE and XRF analysis are important to characterize the elements presents in the objects, pigments and others materials. The digitized radiography has provided important information about the internal structure of the objects, the manufacturing process, the internal particles existing and in case of easel paintings it can reveal features of the artist's creative process showing hidden images and the first paintings done by the artist in the background. Some Brazilian paintings studied by IR imaging revealed underlying drawings, which allowed us to discover the process of creation and also some

  15. Art, historical and cultural heritage objects studied with different non-destructive analysis

    Energy Technology Data Exchange (ETDEWEB)

    Rizzutto, Marcia A.; Tabacniks, Manfredo H.; Added, Nemitala; Campos, Pedro H.O.V.; Curado, Jessica F.; Kajiya, Elizabeth A.M. [Universidade de Sao Paulo (IF/USP), SP (Brazil). Inst. de Fisica

    2012-07-01

    Full text: Since 2003, the analysis of art, historical and cultural heritage objects has being performed at the Laboratorio de Analise de Materiais of the Instituto de Fisica of the Universidade de Sao Paulo (LAMFI-USP). Initially the studies were restricted to non-destructive methods using ion beams to characterize the chemical elements present in the objects. Recently, new analytical techniques and procedures have been incorporated to the better characterization of the objects and the examinations were expanded to other non-destructive analytical techniques such as portable X-Ray fluorescence (XRF), digitalized radiography, high resolution photography with visible, UV (ultraviolet) light and reflectography in the infrared region. These non-destructive analytical techniques systematically applied to the objects are helping the better understanding of these objects and allow studying them by examining their main components; their conservation status and also the creative process of the artist, particularly in easel paintings allow making new discoveries. The setup of the external beam in the LAMFI laboratory is configured to allow different simultaneous analysis by PIXE / PIGE (Particle Induced X-ray emission / Particle Induced gamma rays emission), RBS (Rutherford Backscattering) and IBL (Ion Beam Luminescence) and to expand the archaeometric results using ion beams. PIXE and XRF analysis are important to characterize the elements presents in the objects, pigments and others materials. The digitized radiography has provided important information about the internal structure of the objects, the manufacturing process, the internal particles existing and in case of easel paintings it can reveal features of the artist's creative process showing hidden images and the first paintings done by the artist in the background. Some Brazilian paintings studied by IR imaging revealed underlying drawings, which allowed us to discover the process of creation and also some

  16. [Object-oriented remote sensing image classification in epidemiological studies of visceral leishmaniasis in urban areas].

    Science.gov (United States)

    Almeida, Andréa Sobral de; Werneck, Guilherme Loureiro; Resendes, Ana Paula da Costa

    2014-08-01

    This study explored the use of object-oriented classification of remote sensing imagery in epidemiological studies of visceral leishmaniasis (VL) in urban areas. To obtain temperature and environmental information, an object-oriented classification approach was applied to Landsat 5 TM scenes from the city of Teresina, Piauí State, Brazil. For 1993-1996, VL incidence rates correlated positively with census tracts covered by dense vegetation, grass/pasture, and bare soil and negatively with areas covered by water and densely populated areas. In 2001-2006, positive correlations were found with dense vegetation, grass/pasture, bare soil, and densely populated areas and negative correlations with occupied urban areas with some vegetation. Land surface temperature correlated negatively with VL incidence in both periods. Object-oriented classification can be useful to characterize landscape features associated with VL in urban areas and to help identify risk areas in order to prioritize interventions.

  17. In vitro evaluation of oestrogenic/androgenic activity of the serum organochlorine pesticide mixtures previously described in a breast cancer case–control study

    International Nuclear Information System (INIS)

    Rivero, Javier; Luzardo, Octavio P.; Henríquez-Hernández, Luis A.; Machín, Rubén P.; Pestano, José; Zumbado, Manuel; Boada, Luis D.; Camacho, María; Valerón, Pilar F.

    2015-01-01

    Some organochlorine pesticides (OCs) have been individually linked to breast cancer (BC) because they exert oestrogenic effects on mammary cells. However, humans are environmentally exposed to more or less complex mixtures of these organochlorines, and the biological effects of these mixtures must be elucidated. In this work we evaluated the in vitro effects exerted on human BC cells by the OC mixtures that were most frequently detected in two groups of women who participated in a BC case–control study developed in Spain: healthy women and women diagnosed with BC. The cytotoxicity, oestrogenicity, and androgenicity of the most prevalent OC mixtures found in healthy women (H-mixture) and in BC patients (BC-mixture) were tested at concentrations that resembled those found in the serum of the evaluated women. Our results showed that both OC mixtures presented a similar oestrogenic activity and effect on cell viability, but BC-mixture showed an additional anti-androgenic effect. These results indicate that although the proliferative effect exerted by these mixtures on human breast cells seems to depend mainly on their oestrogenic action, the BC-mixture might additionally induce cell proliferation due to its anti-androgenic activity, therefore increasing the carcinogenic potential of this mixture. The findings of this study demonstrate that subtle variations in the composition of a mixture may induce relevant changes in its biological action. - Highlights: • E-screen and A-screen of two mixtures of organochlorine pesticides (OCP) • Assay concentrations based on a previous breast cancer case–control study • Only non-cytotoxic concentrations assayed • Both OCP mixtures induce proliferation mediated by oestrogen receptor. • OCP mixture of breast cancer patients exhibits additional androgenic activity.

  18. In vitro evaluation of oestrogenic/androgenic activity of the serum organochlorine pesticide mixtures previously described in a breast cancer case–control study

    Energy Technology Data Exchange (ETDEWEB)

    Rivero, Javier; Luzardo, Octavio P., E-mail: octavio.perez@ulpgc.es; Henríquez-Hernández, Luis A.; Machín, Rubén P.; Pestano, José; Zumbado, Manuel; Boada, Luis D.; Camacho, María; Valerón, Pilar F.

    2015-12-15

    Some organochlorine pesticides (OCs) have been individually linked to breast cancer (BC) because they exert oestrogenic effects on mammary cells. However, humans are environmentally exposed to more or less complex mixtures of these organochlorines, and the biological effects of these mixtures must be elucidated. In this work we evaluated the in vitro effects exerted on human BC cells by the OC mixtures that were most frequently detected in two groups of women who participated in a BC case–control study developed in Spain: healthy women and women diagnosed with BC. The cytotoxicity, oestrogenicity, and androgenicity of the most prevalent OC mixtures found in healthy women (H-mixture) and in BC patients (BC-mixture) were tested at concentrations that resembled those found in the serum of the evaluated women. Our results showed that both OC mixtures presented a similar oestrogenic activity and effect on cell viability, but BC-mixture showed an additional anti-androgenic effect. These results indicate that although the proliferative effect exerted by these mixtures on human breast cells seems to depend mainly on their oestrogenic action, the BC-mixture might additionally induce cell proliferation due to its anti-androgenic activity, therefore increasing the carcinogenic potential of this mixture. The findings of this study demonstrate that subtle variations in the composition of a mixture may induce relevant changes in its biological action. - Highlights: • E-screen and A-screen of two mixtures of organochlorine pesticides (OCP) • Assay concentrations based on a previous breast cancer case–control study • Only non-cytotoxic concentrations assayed • Both OCP mixtures induce proliferation mediated by oestrogen receptor. • OCP mixture of breast cancer patients exhibits additional androgenic activity.

  19. Evaluation of the Widal tube agglutination test for the diagnosis of typhoid fever among children admitted to a rural hdospital in Tanzania and a comparison with previous studies

    Directory of Open Access Journals (Sweden)

    Malahiyo Rajabu

    2010-06-01

    Full Text Available Abstract Background The diagnosis of typhoid fever is confirmed by culture of Salmonella enterica serotype Typhi (S. typhi. However, a more rapid, simpler, and cheaper diagnostic method would be very useful especially in developing countries. The Widal test is widely used in Africa but little information exists about its reliability. Methods We assessed the performance of the Widal tube agglutination test among febrile hospitalized Tanzanian children. We calculated the sensitivity, specificity, positive predictive value (PPV, and negative predictive value (NPV of various anti-TH and -TO titers using culture-confirmed typhoid fever cases as the "true positives" and all other febrile children with blood culture negative for S. typhi as the "true negatives." Results We found that 16 (1% of 1,680 children had culture-proven typhoid fever. A single anti-TH titer of 1:80 and higher was the optimal indicator of typhoid fever. This had a sensitivity of 75%, specificity of 98%, NPV of 100%, but PPV was only 26%. We compared our main findings with those from previous studies. Conclusion Among febrile hospitalized Tanzanian children with a low prevalence of typhoid fever, a Widal titer of ≥ 1:80 performed well in terms of sensitivity, specificity, and NPV. However a test with improved PPV that is similarly easy to apply and cost-efficient is desirable.

  20. Caring for women wanting a vaginal birth after previous caesarean section: A qualitative study of the experiences of midwives and obstetricians.

    Science.gov (United States)

    Foureur, Maralyn; Turkmani, Sabera; Clack, Danielle C; Davis, Deborah L; Mollart, Lyndall; Leiser, Bernadette; Homer, Caroline S E

    2017-02-01

    One of the greatest contributors to the overall caesarean section rate is elective repeat caesarean section. Decisions around mode of birth are often complex for women and influenced by the views of the doctors and midwives who care for and counsel women. Women may be more likely to choose a repeat elective caesarean section (CS) if their health care providers lack skills and confidence in supporting vaginal birth after caesarean section (VBAC). To explore the views and experiences of providers in caring for women considering VBAC, in particular the decision-making processes and the communication of risk and safety to women. A descriptive interpretive method was utilised. Four focus groups with doctors and midwives were conducted. The central themes were: 'developing trust', 'navigating the system' and 'optimising support'. The impact of past professional experiences; the critical importance of continuity of carer and positive relationships; the ability to weigh up risks versus benefits; and the language used were all important elements. The role of policy and guidelines on providing standardised care for women who had a previous CS was also highlighted. Midwives and doctors in this study were positively oriented towards assisting and supporting women to attempt a VBAC. Care providers considered that women who have experienced a prior CS need access to midwifery continuity of care with a focus on support, information-sharing and effective communication. Copyright © 2016 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

  1. The Study of Object-Oriented Motor Imagery Based on EEG Suppression.

    Directory of Open Access Journals (Sweden)

    Lili Li

    Full Text Available Motor imagery is a conventional method for brain computer interface and motor learning. To avoid the great individual difference of the motor imagery ability, object-oriented motor imagery was applied, and the effects were studied. Kinesthetic motor imagery and visual observation were administered to 15 healthy volunteers. The EEG during cue-based simple imagery (SI, object-oriented motor imagery (OI, non-object-oriented motor imagery (NI and visual observation (VO was recorded. Study results showed that OI and NI presented significant contralateral suppression in mu rhythm (p 0.05. Compared with NI, OI showed significant difference (p < 0.05 in mu rhythm and weak significant difference (p = 0.0612 in beta rhythm over the contralateral hemisphere. The ability of motor imagery can be reflected by the suppression degree of mu and beta frequencies which are the motor related rhythms. Thus, greater enhancement of activation in mirror neuron system is involved in response to object-oriented motor imagery. The object-oriented motor imagery is favorable for improvement of motor imagery ability.

  2. Parachuting from fixed objects: descriptive study of 106 fatal events in BASE jumping 1981-2006.

    Science.gov (United States)

    Westman, A; Rosén, M; Berggren, P; Björnstig, U

    2008-06-01

    To analyse the characteristics of fatal incidents in fixed object sport parachuting (building, antenna, span, earth (BASE) jumping) and create a basis for prevention. Descriptive epidemiological study. Data on reported fatal injury events (n = 106) worldwide in 1981-2006 retrieved from the BASE fatality list. Human, equipment and environmental factors. Identification of typical fatal incident and injury mechanisms for each of the four fixed object types of BASE jumping (building, antenna, span, earth). Human factors included parachutist free fall instability (loss of body control before parachute deployment), free fall acrobatics and deployment failure by the parachutist. Equipment factors included pilot chute malfunction and parachute malfunction. In cliff jumping (BASE object type E), parachute opening towards the object jumped was the most frequent equipment factor. Environmental factors included poor visibility, strong or turbulent winds, cold and water. The overall annual fatality risk for all object types during the year 2002 was estimated at about one fatality per 60 participants. Participants in BASE jumping should target risk factors with training and technical interventions. The mechanisms described in this study should be used by rescue units to improve the management of incidents.

  3. Prevalence of pain in the head, back and feet in refugees previously exposed to torture: a ten-year follow-up study

    DEFF Research Database (Denmark)

    Olsen, Dorthe Reff; Montgomery, Edith; Bøjholm, Søren

    2007-01-01

    AIM: To estimate change over 10 years concerning the prevalence of pain in the head, back and feet, among previously tortured refugees settled in Denmark, and to compare associations between methods of torture and prevalent pain at baseline and at 10-year follow-up. METHODS: 139 refugees previous...... associated with the type and bodily focus of the torture. This presents a considerable challenge to future evidence-based development of effective treatment programs....

  4. Immunogenicity and safety of tetravalent dengue vaccine in 2-11 year-olds previously vaccinated against yellow fever: randomized, controlled, phase II study in Piura, Peru.

    Science.gov (United States)

    Lanata, Claudio F; Andrade, Teresa; Gil, Ana I; Terrones, Cynthia; Valladolid, Omar; Zambrano, Betzana; Saville, Melanie; Crevat, Denis

    2012-09-07

    In a randomized, placebo-controlled, monocenter, observer blinded study conducted in an area where dengue is endemic, we assessed the safety and immunogenicity of a recombinant, live, attenuated, tetravalent dengue vaccine candidate (CYD-TDV) in 2-11 year-olds with varying levels of pre-existing yellow-fever immunity due to vaccination 1-7 years previously. 199 children received 3 injections of CYD-TDV (months 0, 6 and 12) and 99 received placebo (months 0 and 6) or pneumococcal polysaccharide vaccine (month 12). One month after the third dengue vaccination, serotype specific neutralizing antibody GMTs were in the range of 178-190 (1/dil) (versus 16.7-38.1 in the control group), a 10-20 fold-increase from baseline, and 94% of vaccines were seropositive to all four serotypes (versus 39% in the control group). There were no vaccine-related SAEs. The observed reactogenicity profile was consistent with phase I studies, with severity grade 1-2 injection site pain, headache, malaise and fever most frequently reported and no increase after subsequent vaccinations. Virologically confirmed dengue cases were seen after completion of the 3 doses: 1 in the CYD-TDV group (N=199), and 3 in the control group (N=99). A 3-dose regimen of CYD-TDV had a good safety profile in 2-11 year olds with a history of YF vaccination and elicited robust antibody responses that were balanced against the four serotypes. Copyright © 2012 Elsevier Ltd. All rights reserved.

  5. A phase II study of VP-16-ifosfamide-cisplatin combination chemotherapy plus early concurrent thoracic irradiation for previously untreated limited small cell lung cancer

    International Nuclear Information System (INIS)

    Woo, In Sook; Park, Young Suk; Kwon, Sung Hee

    2000-01-01

    At present the addition of thoracic irradiation to combination chemotherapy is a standard treatment for limited staged small cell ling cancer. However, there is still controversy about the optimum timing of chest irradiation. We conducted a phase II study of etoposide (VP-16)-ifosfamide-cisplatin (VIP) combination chemotherapy plus early concurrent thoracic irradiation for the patients with previously untreated limited small cell lung cancer in order to assess if the treatment modality could improve the response rate and the toxicity. Forty-four patients with limited small cell lung cancer were treated with etoposide-ifosfamide-cisplatin and concurrent thoracic irradiation. Combination chemotherapy consisted of etoposide 100 mg/m 2 (on day 1-3), ifosfamide 1000 mg/m 2 (on days 1 and 2) and cisplatin 100 mg/m 2 (on day 1). Concurrent thoracic irradiation consisted of a total of 4000 cGy over 4 weeks starting on the first day of the first chemotherapy. All patients who showed a complete response were given prophylactic cranial irradiation for 2.5 weeks. Forty-four of the 49 patients who entered the study from May 1994 to August 1998 were evaluable. The median age was 59 years and 40 patients had a performance status of 0 or 1. The median survival time was 22.5 months. Twenty-eight patients (62%) showed a complete response and 16 (38%) a partial response. Twenty-four patients (54%) developed grade 3 or 4 neutropenia; there was a 9% RTOG score 3 or 4 esophagitis. VIP combination chemotherapy and early concurrent thoracic irradiation for patients with limited stage small cell lung cancer revealed excellent antitumor response with tolerable toxicity. (author)

  6. Processing ser and estar to locate objects and events: An ERP study with L2 speakers of Spanish.

    Science.gov (United States)

    Dussias, Paola E; Contemori, Carla; Román, Patricia

    2014-01-01

    In Spanish locative constructions, a different form of the copula is selected in relation to the semantic properties of the grammatical subject: sentences that locate objects require estar while those that locate events require ser (both translated in English as 'to be'). In an ERP study, we examined whether second language (L2) speakers of Spanish are sensitive to the selectional restrictions that the different types of subjects impose on the choice of the two copulas. Twenty-four native speakers of Spanish and two groups of L2 Spanish speakers (24 beginners and 18 advanced speakers) were recruited to investigate the processing of 'object/event + estar/ser ' permutations. Participants provided grammaticality judgments on correct (object + estar ; event + ser ) and incorrect (object + ser ; event + estar ) sentences while their brain activity was recorded. In line with previous studies (Leone-Fernández, Molinaro, Carreiras, & Barber, 2012; Sera, Gathje, & Pintado, 1999), the results of the grammaticality judgment for the native speakers showed that participants correctly accepted object + estar and event + ser constructions. In addition, while 'object + ser ' constructions were considered grossly ungrammatical, 'event + estar ' combinations were perceived as unacceptable to a lesser degree. For these same participants, ERP recording time-locked to the onset of the critical word ' en ' showed a larger P600 for the ser predicates when the subject was an object than when it was an event (*La silla es en la cocina vs. La fiesta es en la cocina). This P600 effect is consistent with syntactic repair of the defining predicate when it does not fit with the adequate semantic properties of the subject. For estar predicates (La silla está en la cocina vs. *La fiesta está en la cocina), the findings showed a central-frontal negativity between 500-700 ms. Grammaticality judgment data for the L2 speakers of Spanish showed that beginners were significantly less accurate than

  7. A Qualitative Study of US Clinical Ethics Services: Objectives and Outcomes.

    Science.gov (United States)

    McClimans, Leah; Pressgrove, Geah; Rhea, James

    2016-01-01

    The quality of clinical ethics services in health care organizations is increasingly seen as an important aspect of the overall quality of care. But measuring this quality is difficult because there is a lack of clarity and consensus regarding the objectives of clinical ethics and the best outcome domains to measure. The aim of this qualitative study is to explore the views of experts about the objectives and outcomes of clinical ethics services in the US. We interviewed 19 experts in clinical ethics, focusing on the appropriate objectives and outcomes of a clinical ethics service (CES). Participants were selected using a purposive snowball sampling strategy. The development of the interview protocol was informed by the clinical ethics literature as well as by research and theories that inform clinical ethics practice. Interviews were conducted by phone, recorded, and transcribed for individual analysis. Analysis proceeded through the development of a codebook of categories using QDA Miner software. Our experts identified 12 objectives and nine outcomes. Some of these identifications were familiar (e.g., mediation and satisfaction) and some were novel (e.g., be of service and transformation). We found that experts are divided in their emphasis on the kinds of objectives that are most important. In terms of outcomes, our experts were concerned with the appropriateness of different proxy and direct measures. This study provides the perspectives of a select group of experts on the objectives and outcomes appropriate for a CES in the United States. The themes identified will be used in future research to inform a Delphi study to refine and obtain expert consensus.

  8. The use of metabolic balance studies in the objective discrimination between intestinal insufficiency and intestinal failure

    DEFF Research Database (Denmark)

    Prahm, August P; Brandt, Christopher F; Askov-Hansen, Carsten

    2017-01-01

    Background: In research settings that use metabolic balance studies (MBSs) of stable adult patients with short bowel syndrome, intestinal failure (IF) and dependence on parenteral support (PS) have been defined objectively as energy absorption metabolic rate (BMR), wet......, to objectivize the cause of nutritional dyshomeostasis (oral failure, malabsorption, or both), and to quantify the effects of treatment....

  9. Embodying the institution - Object manipulation in developing interaction in study counselling meetings

    DEFF Research Database (Denmark)

    Hazel, Spencer; Mortensen, Kristian

    2014-01-01

    on how objects in the material surround are used in conjunction with talk, gaze and postural orientation to construct local social order in study guidance counselling meetings at a university. We explore here how co-participants utilize aggregates of interactional components to construct...

  10. A Longitudinal Study of Objectively Measured Built Environment as Determinant of Physical Activity in Young Adults

    DEFF Research Database (Denmark)

    Schipperijn, Jasper; Ried-Larsen, Mathias; Nielsen, Merete S

    2015-01-01

    in the Danish part of the European Youth Hearth Study (EYHS) was used to examine the effect of the built environment on PA. A MI was developed using objectively measured built environment characteristics, and included residential density, recreational facilities, daily destinations and street connectivity...

  11. Coupling Uncertainties with Accuracy Assessment in Object-Based Slum Detections, Case Study: Jakarta, Indonesia

    NARCIS (Netherlands)

    Pratomo, J.; Kuffer, M.; Martinez, Javier; Kohli, D.

    2017-01-01

    Object-Based Image Analysis (OBIA) has been successfully used to map slums. In general, the occurrence of uncertainties in producing geographic data is inevitable. However, most studies concentrated solely on assessing the classification accuracy and neglecting the inherent uncertainties. Our

  12. Say it with flowers! An fMRI study of object mediated communication

    DEFF Research Database (Denmark)

    Tylén, Kristian; Wallentin, Mikkel; Roepstorff, Andreas

    2009-01-01

    Human communicational interaction can be mediated by a host of expressive means from words in a natural language to gestures and material symbols. Given the proper contextual setting even an everyday object can gain a mediating function in a communicational situation. In this study we used event...

  13. A Sociolinguistic Study of Differential Object Marking (DOM) in Two Varieties of Contemporary Spanish

    Science.gov (United States)

    Balasch Rodriguez, Sonia

    2011-01-01

    This sociolinguistic-variationist investigation sheds light on two little-studied issues concerning Spanish DOM, or variable use of a before animate "direct objects" (DOs), in vernacular language: the complex interaction of co-occurring linguistic (type of verb; definiteness, specificity, grammatical number, topicality, type and…

  14. How healthcare professionals respond to parents with religious objections to vaccination: a qualitative study

    Directory of Open Access Journals (Sweden)

    Ruijs Wilhelmina LM

    2012-08-01

    Full Text Available Abstract Background In recent years healthcare professionals have faced increasing concerns about the value of childhood vaccination and many find it difficult to deal with parents who object to vaccination. In general, healthcare professionals are advised to listen respectfully to the objections of parents, provide honest information, and attempt to correct any misperceptions regarding vaccination. Religious objections are one of the possible reasons for refusing vaccination. Although religious objections have a long history, little is known about the way healthcare professionals deal with these specific objections. The aim of this study is to gain insight into the responding of healthcare professionals to parents with religious objections to the vaccination of their children. Methods A qualitative interview study was conducted with health care professionals (HCPs in the Netherlands who had ample experience with religious objections to vaccination. Purposeful sampling was applied in order to include HCPs with different professional and religious backgrounds. Data saturation was reached after 22 interviews, with 7 child health clinic doctors, 5 child health clinic nurses and 10 general practitioners. The interviews were thematically analyzed. Two analysts coded, reviewed, discussed, and refined the coding of the transcripts until consensus was reached. Emerging concepts were assessed using the constant comparative method from grounded theory. Results Three manners of responding to religious objections to vaccination were identified: providing medical information, discussion of the decision-making process, and adoption of an authoritarian stance. All of the HCPs provided the parents with medical information. In addition, some HCPs discussed the decision-making process. They verified how the decision was made and if possible consequences were realized. Sometimes they also discussed religious considerations. Whether the decision-making process was

  15. How healthcare professionals respond to parents with religious objections to vaccination: a qualitative study.

    Science.gov (United States)

    Ruijs, Wilhelmina L M; Hautvast, Jeannine L A; van IJzendoorn, Giovanna; van Ansem, Wilke J C; Elwyn, Glyn; van der Velden, Koos; Hulscher, Marlies E J L

    2012-08-01

    In recent years healthcare professionals have faced increasing concerns about the value of childhood vaccination and many find it difficult to deal with parents who object to vaccination. In general, healthcare professionals are advised to listen respectfully to the objections of parents, provide honest information, and attempt to correct any misperceptions regarding vaccination. Religious objections are one of the possible reasons for refusing vaccination. Although religious objections have a long history, little is known about the way healthcare professionals deal with these specific objections. The aim of this study is to gain insight into the responding of healthcare professionals to parents with religious objections to the vaccination of their children. A qualitative interview study was conducted with health care professionals (HCPs) in the Netherlands who had ample experience with religious objections to vaccination. Purposeful sampling was applied in order to include HCPs with different professional and religious backgrounds. Data saturation was reached after 22 interviews, with 7 child health clinic doctors, 5 child health clinic nurses and 10 general practitioners. The interviews were thematically analyzed. Two analysts coded, reviewed, discussed, and refined the coding of the transcripts until consensus was reached. Emerging concepts were assessed using the constant comparative method from grounded theory. Three manners of responding to religious objections to vaccination were identified: providing medical information, discussion of the decision-making process, and adoption of an authoritarian stance. All of the HCPs provided the parents with medical information. In addition, some HCPs discussed the decision-making process. They verified how the decision was made and if possible consequences were realized. Sometimes they also discussed religious considerations. Whether the decision-making process was discussed depended on the willingness of the parents to

  16. A Practical Study of Control in Objected-Oriented–Functional–Logic Programming with Paisley

    Directory of Open Access Journals (Sweden)

    Baltasar Trancón y Widemann

    2017-01-01

    Full Text Available Paisley is an extensible lightweight embedded domain-specific language for nondeterministic pattern matching in Java. Using simple APIs and programming idioms, it brings the power of functional-logic processing of arbitrary data objects to the Java platform, without constraining the underlying object-oriented semantics. Here we present an extension to the Paisley framework that adds pattern-based control flow. It exploits recent additions to the Java language, namely functional interfaces and lambda expressions, for an explicit and transparent continuation-passing style approach to control. We evaluate the practical impact of the novel features on a real-world case study that reengineers a third-party open-source project to use Paisley in place of conventional object-oriented data query idioms. We find the approach viable for incremental refactoring of legacy code, with significant qualitative improvements regarding separation of concerns, clarity and intentionality, thus making for easier code understanding, testing and debugging.

  17. THE OBJECTIVE OF ISLAMIC BANK: A CASE STUDY IN SURAKARTA REGION

    Directory of Open Access Journals (Sweden)

    Ibrahim Fatwa Wijaya

    2017-03-01

    Full Text Available The purposes of this research were for exploring the perception of the Islamic Banking stakeholders relatedwith the objective of Islamic Banking that operated in the dual banking system, Indonesia and for measuringthe gap between the perception and expectation of the stakeholders toward the objective of Islamic bank. Theprimary data was collected by questionnaires. The Respondents were limited only in the Surakarta region.They were customers, lecturers, students, employees, bank managers, regulators, and ulama (Moslem religiousteachers. Factor analysis was conducted for grouping or classifying the variables into the same group whichhad the same characters while Kruskall Wallis test was used for examining the different perception among thestakeholders. At last, paired sample t-test was used to measure the gap between perception and expectationamong the stakeholders. The findings of this study were first, stakeholders concluded that social objective ofIslamic was more important than the commercial one; second, there was a significant different perception on theIslamic Banking objective among the stakeholders; and third, there was a gap between the perception andexpectation of the stakeholders about Islamic Banking objectives.

  18. Multi-wavelength studies of TeV γ-ray emitting BL Lac objects

    Energy Technology Data Exchange (ETDEWEB)

    Kaufmann, Sarah Sabine

    2012-12-21

    The discovery of TeV γ-ray emission of BL Lac objects gave new insights in the particle acceleration and the emission processes of the highly relativistic jets. To shed light on the conditions in the high energetic jets of the TeV γ-ray emitting BL Lac objects, I have studied in great detail the spectral energy distribution (SED) of sources with different characteristics. BL Lac objects with exceptional very high energy spectra (soft and hard spectra) and with large differences in the emission peak frequencies, to cover the different classes of BL Lac objects, have been chosen. The basic aim of this thesis was, to study with new, simultaneous multi- avelength (MWL) observations, if the emission processes of these extreme cases of TeV BL Lac objects can be explained by the synchrotron Self-Compton (SSC) model which is well established for the class of BL Lac objects at lower energies. We proposed MWL observations in the optical, UV and X-ray regime, to be conducted simultaneous to very high energy observations with the H.E.S.S. experiment, to study the emission processes. Simultaneous observations are crucial, since BL Lac objects are variable at all wavebands. I have analysed the MWL observations and conducted detailed variability and spectral studies in each wavelength range. The different kind of absorption at each wavelength as well as the influence of the host galaxy of the AGN has been considered to obtain the intrinsic jet spectrum. I have then applied the commonly used theoretical jet model, the SSC model, to the SED. I conducted a MWL campaign on a BL Lac object with the softest TeV spectrum, PKS 2005-489, during which it was observed in a very bright X-ray state. The good spectral coverage of the emission peaks allowed a detailed study of the SSC model. The extreme BL Lac object 1ES 0229+200 exhibits a hard intrinsic TeV spectrum. With my MWL campaign I found a clear cut-off in the optical range and therefore a high minimum Lorentz factor is needed to

  19. Multi-wavelength studies of TeV γ-ray emitting BL Lac objects

    International Nuclear Information System (INIS)

    Kaufmann, Sarah Sabine

    2012-01-01

    The discovery of TeV γ-ray emission of BL Lac objects gave new insights in the particle acceleration and the emission processes of the highly relativistic jets. To shed light on the conditions in the high energetic jets of the TeV γ-ray emitting BL Lac objects, I have studied in great detail the spectral energy distribution (SED) of sources with different characteristics. BL Lac objects with exceptional very high energy spectra (soft and hard spectra) and with large differences in the emission peak frequencies, to cover the different classes of BL Lac objects, have been chosen. The basic aim of this thesis was, to study with new, simultaneous multi- avelength (MWL) observations, if the emission processes of these extreme cases of TeV BL Lac objects can be explained by the synchrotron Self-Compton (SSC) model which is well established for the class of BL Lac objects at lower energies. We proposed MWL observations in the optical, UV and X-ray regime, to be conducted simultaneous to very high energy observations with the H.E.S.S. experiment, to study the emission processes. Simultaneous observations are crucial, since BL Lac objects are variable at all wavebands. I have analysed the MWL observations and conducted detailed variability and spectral studies in each wavelength range. The different kind of absorption at each wavelength as well as the influence of the host galaxy of the AGN has been considered to obtain the intrinsic jet spectrum. I have then applied the commonly used theoretical jet model, the SSC model, to the SED. I conducted a MWL campaign on a BL Lac object with the softest TeV spectrum, PKS 2005-489, during which it was observed in a very bright X-ray state. The good spectral coverage of the emission peaks allowed a detailed study of the SSC model. The extreme BL Lac object 1ES 0229+200 exhibits a hard intrinsic TeV spectrum. With my MWL campaign I found a clear cut-off in the optical range and therefore a high minimum Lorentz factor is needed to

  20. MULTIPLE OBJECTS

    Directory of Open Access Journals (Sweden)

    A. A. Bosov

    2015-04-01

    Full Text Available Purpose. The development of complicated techniques of production and management processes, information systems, computer science, applied objects of systems theory and others requires improvement of mathematical methods, new approaches for researches of application systems. And the variety and diversity of subject systems makes necessary the development of a model that generalizes the classical sets and their development – sets of sets. Multiple objects unlike sets are constructed by multiple structures and represented by the structure and content. The aim of the work is the analysis of multiple structures, generating multiple objects, the further development of operations on these objects in application systems. Methodology. To achieve the objectives of the researches, the structure of multiple objects represents as constructive trio, consisting of media, signatures and axiomatic. Multiple object is determined by the structure and content, as well as represented by hybrid superposition, composed of sets, multi-sets, ordered sets (lists and heterogeneous sets (sequences, corteges. Findings. In this paper we study the properties and characteristics of the components of hybrid multiple objects of complex systems, proposed assessments of their complexity, shown the rules of internal and external operations on objects of implementation. We introduce the relation of arbitrary order over multiple objects, we define the description of functions and display on objects of multiple structures. Originality.In this paper we consider the development of multiple structures, generating multiple objects.Practical value. The transition from the abstract to the subject of multiple structures requires the transformation of the system and multiple objects. Transformation involves three successive stages: specification (binding to the domain, interpretation (multiple sites and particularization (goals. The proposed describe systems approach based on hybrid sets

  1. A Study on Re-entry Predictions of Uncontrolled Space Objects for Space Situational Awareness

    Science.gov (United States)

    Choi, Eun-Jung; Cho, Sungki; Lee, Deok-Jin; Kim, Siwoo; Jo, Jung Hyun

    2017-12-01

    The key risk analysis technologies for the re-entry of space objects into Earth’s atmosphere are divided into four categories: cataloguing and databases of the re-entry of space objects, lifetime and re-entry trajectory predictions, break-up models after re-entry and multiple debris distribution predictions, and ground impact probability models. In this study, we focused on re- entry prediction, including orbital lifetime assessments, for space situational awareness systems. Re-entry predictions are very difficult and are affected by various sources of uncertainty. In particular, during uncontrolled re-entry, large spacecraft may break into several pieces of debris, and the surviving fragments can be a significant hazard for persons and properties on the ground. In recent years, specific methods and procedures have been developed to provide clear information for predicting and analyzing the re-entry of space objects and for ground-risk assessments. Representative tools include object reentry survival analysis tool (ORSAT) and debris assessment software (DAS) developed by National Aeronautics and Space Administration (NASA), spacecraft atmospheric re-entry and aerothermal break-up (SCARAB) and debris risk assessment and mitigation analysis (DRAMA) developed by European Space Agency (ESA), and semi-analytic tool for end of life analysis (STELA) developed by Centre National d’Etudes Spatiales (CNES). In this study, various surveys of existing re-entry space objects are reviewed, and an efficient re-entry prediction technique is suggested based on STELA, the life-cycle analysis tool for satellites, and DRAMA, a re-entry analysis tool. To verify the proposed method, the re-entry of the Tiangong-1 Space Lab, which is expected to re-enter Earth’s atmosphere shortly, was simulated. Eventually, these results will provide a basis for space situational awareness risk analyses of the re-entry of space objects.

  2. Food and Drug Administration criteria for the diagnosis of drug-induced valvular heart disease in patients previously exposed to benfluorex: a prospective multicentre study.

    Science.gov (United States)

    Maréchaux, Sylvestre; Rusinaru, Dan; Jobic, Yannick; Ederhy, Stéphane; Donal, Erwan; Réant, Patricia; Arnalsteen, Elise; Boulanger, Jacques; Garban, Thierry; Ennezat, Pierre-Vladimir; Jeu, Antoine; Szymanski, Catherine; Tribouilloy, Christophe

    2015-02-01

    The Food and Drug Administration (FDA) criteria for diagnosis of drug-induced valvular heart disease (DIVHD) are only based on the observation of aortic regurgitation ≥ mild and/or mitral regurgitation ≥ moderate. We sought to evaluate the diagnostic value of FDA criteria in a cohort of control patients and in a cohort of patients exposed to a drug (benfluorex) known to induce VHD. This prospective, multicentre study included 376 diabetic control patients not exposed to valvulopathic drugs and 1000 subjects previously exposed to benfluorex. Diagnosis of mitral or aortic DIVHD was based on a combined functional and morphological echocardiographic analysis of cardiac valves. Patients were classified according to the FDA criteria [mitral or aortic-FDA(+) and mitral or aortic-FDA(-)]. Among the 376 control patients, 2 were wrongly classified as mitral-FDA(+) and 17 as aortic-FDA(+) (0.53 and 4.5% of false positives, respectively). Of those exposed to benfluorex, 48 of 58 with a diagnosis of mitral DIVHD (83%) were classified as mitral-FDA(-), and 901 of the 910 patients (99%) without a diagnosis of the mitral DIVHD group were classified as mitral-FDA(-). All 40 patients with a diagnosis of aortic DIVHD were classified as aortic-FDA(+), and 105 of the 910 patients without a diagnosis of aortic DIVHD (12%) were classified aortic-FDA(+). Older age and lower BMI were independent predictors of disagreement between FDA criteria and the diagnosis of DIVHD in patients exposed to benfluorex (both P ≤ 0.001). FDA criteria solely based on the Doppler detection of cardiac valve regurgitation underestimate for the mitral valve and overestimate for the aortic valve the frequency of DIVHD. Therefore, the diagnosis of DIVHD must be based on a combined echocardiographic and Doppler morphological and functional analysis of cardiac valves. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.

  3. SAFETY AND ACTIVITY OF TEMSIROLIMUS AND BEVACIZUMAB IN PATIENTS WITH ADVANCED RENAL CELL CARCINOMA PREVIOUSLY TREATED WITH TYROSINE KINASE INHIBITORS: A PHASE 2 CONSORTIUM STUDY

    Science.gov (United States)

    Merchan, Jaime R.; Qin, Rui; Pitot, Henry; Picus, Joel; Liu, Glenn; Fitch, Tom; Maples, William J.; Flynn, Patrick J.; Fruth, Briant F.; Erlichman, Charles

    2015-01-01

    Purpose Bevacizumab or Temsirolimus regimens have clinical activity in the first line treatment of advanced renal cell carcinoma (RCC). This phase I/II trial was conducted to determine the safety of combining both agents and its efficacy in RCC patients who progressed on at least one prior anti-VEGF receptor tyrosine kinase inhibitor (RTKI) agent. Methods In the phase I portion, eligible patients were treated with Temsirolimus (25 mg IV weekly) and escalating doses of IV Bevacizumab (level 1=5mg/kg; level 2=10 mg/kg) every other week. The primary endpoint for the phase II portion (RTKI resistant patients) was the 6-month progression free rate. Secondary endpoints were response rate, toxicity evaluation, PFS and OS. Results MTD was not reached at the maximum dose administered in 12 phase I patients. Forty evaluable patients were treated with the phase II recommended dose (Temsirolimus 25 mg IV weekly and Bevacizumab 10 mg/kg IV every two weeks). The 6-month progression free rate was 40% (16/40 pts). Median PFS was 5.9 (4-7.8) months, and median OS was 20.6 (11.5-23.7) months. Partial response/stable/progressive disease were seen in 23%/63%/14% of patients. Most common grade 3-4 AEs included fatigue (17.8%), hypertriglyceridemia (11.1%), stomatitis (8.9%), proteinuria (8.9%), abdominal pain (6.7%), and anemia (6.7%). Baseline levels of serum sFLT-1 and VEGF-A were inversely correlated with PFS and OS, respectively. Conclusions Temsirolimus and Bevacizumab is a feasible combination in patients with advanced RCC previously exposed to oral anti-VEGF agents. The safety and efficacy results warrant further confirmatory studies in this patient population. PMID:25556030

  4. Low-calorie energy drink improves physiological response to exercise in previously sedentary men: a placebo-controlled efficacy and safety study.

    Science.gov (United States)

    Lockwood, Christopher M; Moon, Jordan R; Smith, Abbie E; Tobkin, Sarah E; Kendall, Kristina L; Graef, Jennifer L; Cramer, Joel T; Stout, Jeffrey R

    2010-08-01

    Energy drink use has grown despite limited research to support efficacy or safety and amid concerns when combined with exercise. The purpose of this study was to assess the effects of 10 weeks of once-daily energy drink consumption or energy drink consumption with exercise on measures of body composition, cardiorespiratory fitness, strength, mood, and safety in previously sedentary males. Thirty-eight males were randomly assigned to energy drink + exercise (EX-A), energy drink (NEX-A), placebo + exercise (EX-B), or placebo (NEX-B). All participants consumed 1 drink per day for 10 weeks; EX-A and EX-B participated in 10 weeks of resistance and endurance exercise. Testing was performed before (PRE) and after (POST) the 10-week intervention. No significant (p > 0.05) changes were observed for body composition, fitness, or strength in NEX-A; however, significantly greater decreases in fat mass and percentage body fat and increases in VO2peak were observed in EX-A versus EX-B. Ventilatory threshold (VT), minute ventilation, VO2 at VT, and power output at VT improved significantly PRE to POST in EX-A but not in EX-B or nonexercising groups. Clinical markers for hepatic, renal, cardiovascular, and immune function, as determined by PRE and POST blood work revealed no adverse effects in response to the energy drink. Mood was not affected by energy drink use. Absent energy restriction or other dietary controls, chronic ingestion of a once-daily low-calorie energy drink appears ineffective at improving body composition, cardiorespiratory fitness, or strength in sedentary males. However, when combined with exercise, preworkout energy drink consumption may significantly improve some physiological adaptations to combined aerobic and resistance training.

  5. Phase I/II study of gefitinib (Iressa(®)) and vorinostat (IVORI) in previously treated patients with advanced non-small cell lung cancer.

    Science.gov (United States)

    Han, Ji-Youn; Lee, Soo Hyun; Lee, Geon Kook; Yun, Tak; Lee, Young Joo; Hwang, Kum Hui; Kim, Jin Young; Kim, Heung Tae

    2015-03-01

    Vorinostat has been shown to overcome resistance to gefitinib. We performed a phase I/II study combining gefitinib with vorinostat in previously treated non-small cell lung cancer (NSCLC). A 3 + 3 dose-escalation design was used to determine maximum tolerated dose (MTD) and recommended phase II dose (RP2D). Three dose levels were tested: 250 mg/day gefitinib on days 1-28 and 200, 300 or 400 mg/day vorinostat on days 1-7, and 15-21 out of every 28 days. The primary endpoint was median progression-free survival (PFS). Fifty-two patients were enrolled and treated (43 in phase II). The median age was 59 years, 28 patients were male, 44 had adenocarcinoma, 29 had never smoked, and 36 had undergone one prior treatment. Twenty-two patients exhibited sensitive EGFR mutations. Planned dose escalation was completed without reaching the MTD. The RP2D was 250 mg gefitinib and 400 mg vorinostat. In 43 assessable patients in phase II, the median PFS was 3.2 months; the overall survival (OS) was 19.0 months. There were 16 partial responses and six cases of stable disease. In EGFR-mutant NSCLC, response rate was 77 %, median PFS was 9.1 months, and median OS was 24.1 months. The most common adverse events were anorexia and diarrhea. Treatment with 250 mg gefitinib daily with biweekly 400 mg/day vorinostat was feasible and well tolerated. In an unselected patient population, this combination dose did not improve PFS. However, this combination showed a potential for improving efficacy of gefitinib in EGFR-mutant NSCLC (NCT01027676).

  6. Effect of donepezil in patients with Alzheimer's disease previously untreated or treated with memantine or nootropic agents in Germany: an observational study.

    Science.gov (United States)

    Klinger, Tatjana; Ibach, Bernd; Schoenknecht, Peter; Kamleiter, Martin; Silver, Gabrielle; Schroeder, Johannes; Mielke, Ruediger

    2005-05-01

    This open-label, prospective, observational, Post-Marketing Surveillance (PMS) study assessed the efficacy and safety of donepezil in patients who had been switched from therapies currently used in Germany to treat Alzheimer's disease (AD), such as memantine and nootropics, due to insufficient efficacy or poor tolerability. A treatment-naive population was included as a comparator. Patients with AD were treated with donepezil and observed for a period of approximately 3 months. A cognitive assessment was made using the Mini-Mental State Examination (MMSE). Quality of life (QoL) was assessed by the investigators who answered the question 'How did therapy with donepezil influence the QoL of the patient and/or his family over the observation period?' and was graded using three ratings: improved/unchanged/worsened. Adverse events (AEs) were also monitored. A total of 913 patients entered the study (mean +/- SD MMSE score 18.03 +/- 5.34). Efficacy assessments were analyzed for three groups: an overall group of patients who had received any form of prior AD drug therapy (N+ group; n = 709); a subgroup of patients from the N+ group who had received prior memantine therapy only (M+ group; n = 111) and patients who were drug treatment naive (N- group; n = 204). In the evaluable population donepezil improved MMSE scores by 2.21 +/- 3.47 points on average, with similar improvements observed in all three groups. QoL was judged to be improved in at least 70% of patients, again with similar results obtained for all three groups. Donepezil was well tolerated, with 85 of 913 (9.3%) patients reporting AEs. The most common AEs were those typically seen with cholinergic therapies (i.e., diarrhoea, vomiting and nausea). In this observational PMS study, donepezil was shown to be efficacious and well tolerated in patients who were being insufficiently treated with memantine or nootropic therapy. The magnitude of response was similar to that observed in patients who were previously

  7. Object and Action Naming: A Study on Persian-Speaking Children

    Directory of Open Access Journals (Sweden)

    Reza Nilipour

    2013-04-01

    Full Text Available Objectives: Nouns and verbs are the central conceptual linguistic units of language acquisition in all human languages. While the noun-bias hypothesis claims that nouns have a privilege in children’s lexical development across languages, studies on Mandarin and Korean and other languages have challenged this view. More recent cross-linguistic naming studies on children in German, Turkish, English and Korean demonstrate that all languages, including Korean show a noun advantage however the degree of this discrepancy differs between languages. The aim of this study wasto look at object and action naming in normal Persian children as a measure of conceptual developmentin preschool children and its possible use for screening and therapeutic procedures. Methods: In this analytical study, noun bias and processing dissociation of object and action naming in 64 three to six year old healthy monolingual Persian-speaking children was investigated. A black and white picture naming task, consisting of 36 nouns (natural and man-made, and 36 verbs (transitive and intransitive was designed using DMDX software to measure response accuracy and reaction time of the subjects. Results: The results indicate a significant noun advantage with regard to accuracy and naming latencies. The results also reveal that transitive verbs are named more accurately than intransitive ones in Persianspeaking children. Also,the data indicate that accuracy of object and action namingimprove with age (P=0.000. Discussion: Based on the resultswe recommended that a standardized Persian object and action naming battery be used. Such a tool would have the potential of screening lexical development delay and possible noun-verb performance gap in preschool children.

  8. Sunburn and sun-protective behaviors among adults with and without previous nonmelanoma skin cancer (NMSC): A population-based study.

    Science.gov (United States)

    Fischer, Alexander H; Wang, Timothy S; Yenokyan, Gayane; Kang, Sewon; Chien, Anna L

    2016-08-01

    Individuals with previous nonmelanoma skin cancer (NMSC) are at increased risk for subsequent skin cancer, and should therefore limit ultraviolet exposure. We sought to determine whether individuals with previous NMSC engage in better sun protection than those with no skin cancer history. We pooled self-reported data (2005 and 2010 National Health Interview Surveys) from US non-Hispanic white adults (758 with and 34,161 without previous NMSC). We calculated adjusted prevalence odds ratios (aPOR) and 95% confidence intervals (CI), taking into account the complex survey design. Individuals with previous NMSC versus no history of NMSC had higher rates of frequent use of shade (44.3% vs 27.0%; aPOR 1.41; 95% CI 1.16-1.71), long sleeves (20.5% vs 7.7%; aPOR 1.55; 95% CI 1.21-1.98), a wide-brimmed hat (26.1% vs 10.5%; aPOR 1.52; 95% CI 1.24-1.87), and sunscreen (53.7% vs 33.1%; aPOR 2.11; 95% CI 1.73-2.59), but did not have significantly lower odds of recent sunburn (29.7% vs 40.7%; aPOR 0.95; 95% CI 0.77-1.17). Among those with previous NMSC, recent sunburn was inversely associated with age, sun avoidance, and shade but not sunscreen. Self-reported cross-sectional data and unavailable information quantifying regular sun exposure are limitations. Physicians should emphasize sunburn prevention when counseling patients with previous NMSC, especially younger adults, focusing on shade and sun avoidance over sunscreen. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  9. Ecological validity and infant research: An example from an experimental study on object individuation with familiar objects in 8-month-old infants

    DEFF Research Database (Denmark)

    Krøjgaard, Peter

    shall attempt to apply an analysis based on the concept of ecological validity on a specific experimental study within the field of infant cognition. I will attempt to show that such an analysis can be worthwhile.The presentation falls in three sections. The first section is a presentation...... might make a difference when infants reason about the physical world. For example, it might be argued that infants would probably pay more attention to ‘disappearing' familiar objects compared to novel ones. Using the so-called "violation-of-expectation" method, the study employed a design that recently...... on the infants' ability to individuate objects in the present design.In the third and final section the results obtained in the experiment are discussed, not only in relation to the existing litterature within the field of research of object individuation, but also by specificly applying the concept...

  10. Multi-Objective Optimization for Energy Performance Improvement of Residential Buildings: A Comparative Study

    Directory of Open Access Journals (Sweden)

    Kangji Li

    2017-02-01

    Full Text Available Numerous conflicting criteria exist in building design optimization, such as energy consumption, greenhouse gas emission and indoor thermal performance. Different simulation-based optimization strategies and various optimization algorithms have been developed. A few of them are analyzed and compared in solving building design problems. This paper presents an efficient optimization framework to facilitate optimization designs with the aid of commercial simulation software and MATLAB. The performances of three optimization strategies, including the proposed approach, GenOpt method and artificial neural network (ANN method, are investigated using a case study of a simple building energy model. Results show that the proposed optimization framework has competitive performances compared with the GenOpt method. Further, in another practical case, four popular multi-objective algorithms, e.g., the non-dominated sorting genetic algorithm (NSGA-II, multi-objective particle swarm optimization (MOPSO, the multi-objective genetic algorithm (MOGA and multi-objective differential evolution (MODE, are realized using the propose optimization framework and compared with three criteria. Results indicate that MODE achieves close-to-optimal solutions with the best diversity and execution time. An uncompetitive result is achieved by the MOPSO in this case study.

  11. A study of earthquake-induced building detection by object oriented classification approach

    Science.gov (United States)

    Sabuncu, Asli; Damla Uca Avci, Zehra; Sunar, Filiz

    2017-04-01

    Among the natural hazards, earthquakes are the most destructive disasters and cause huge loss of lives, heavily infrastructure damages and great financial losses every year all around the world. According to the statistics about the earthquakes, more than a million earthquakes occur which is equal to two earthquakes per minute in the world. Natural disasters have brought more than 780.000 deaths approximately % 60 of all mortality is due to the earthquakes after 2001. A great earthquake took place at 38.75 N 43.36 E in the eastern part of Turkey in Van Province on On October 23th, 2011. 604 people died and about 4000 buildings seriously damaged and collapsed after this earthquake. In recent years, the use of object oriented classification approach based on different object features, such as spectral, textural, shape and spatial information, has gained importance and became widespread for the classification of high-resolution satellite images and orthophotos. The motivation of this study is to detect the collapsed buildings and debris areas after the earthquake by using very high-resolution satellite images and orthophotos with the object oriented classification and also see how well remote sensing technology was carried out in determining the collapsed buildings. In this study, two different land surfaces were selected as homogenous and heterogeneous case study areas. In the first step of application, multi-resolution segmentation was applied and optimum parameters were selected to obtain the objects in each area after testing different color/shape and compactness/smoothness values. In the next step, two different classification approaches, namely "supervised" and "unsupervised" approaches were applied and their classification performances were compared. Object-based Image Analysis (OBIA) was performed using e-Cognition software.

  12. Does local endometrial injury in the nontransfer cycle improve the IVF-ET outcome in the subsequent cycle in patients with previous unsuccessful IVF? A randomized controlled pilot study

    Directory of Open Access Journals (Sweden)

    Sachin A Narvekar

    2010-01-01

    Full Text Available Background: Management of repeated implantation failure despite transfer of good-quality embryos still remains a dilemma for ART specialists. Scrapping of endometrium in the nontransfer cycle has been shown to improve the pregnancy rate in the subsequent IVF/ET cycle in recent studies. Aim: The objective of this randomized controlled trial (RCT was to determine whether endometrial injury caused by Pipelle sampling in the nontransfer cycle could improve the probability of pregnancy in the subsequent IVF cycle in patients who had previous failed IVF outcome. Setting: Tertiary assisted conception center. Design: Randomized controlled study. Materials and Methods: 100 eligible patients with previous failed IVF despite transfer of good-quality embryos were randomly allocated to the intervention group and control groups. In the intervention group, Pipelle endometrial sampling was done twice: One in the follicular phase and again in the luteal phase in the cycle preceding the embryo transfer cycle. Outcome Measure: The primary outcome measure was live birth rate. The secondary outcome measures were implantation and clinical pregnancy rates. Results: The live birth rate was significantly higher in the intervention group compared to control group (22.4% and 9.8% P = 0.04. The clinical pregnancy rate in the intervention group was 32.7%, while that in the control group was 13.7%, which was also statistically significant ( P = 0.01. The implantation rate was significantly higher in the intervention group as compared to controls (13.07% vs 7.1% P = 0.04. Conclusions: Endometrial injury in nontransfer cycle improves the live birth rate,clinical pregnancy and implantation rates in the subsequent IVF-ET cycle in patients with previous unsuccessful IVF cycles.

  13. [Explore objective clinical variables for detecting delirium in ICU patients: a prospective case-control study].

    Science.gov (United States)

    Liu, Xiaojiang; Lyu, Jie; An, Youzhong

    2017-04-01

    The aim of this case-control study is to explore clinical objective variables for diagnosing delirium of intensive care unit (ICU) patients. According to the method of prospective case-control study, critical adult postoperative patients who were transferred to ICU of Peking University People's Hospital from October 2015 to May 2016 and needed mechanical ventilation were included. After evaluating the Richmond agitation sedation scale score (RASS), the patients whose score were -2 or greater were sorted into two groups, delirium and non-delirium, according to the confusion assessment method for the ICU (CAM-ICU). Then these patients were observed by domestic multifunctional detector for electroencephalographic (EEG) variables such as brain lateralization, brain introvert, brain activity, brain energy consumption, focus inward, focus outward, cerebral inhibition, fatigue, sleep severity, sedation index, pain index, anxiety index, fidgety index, stress index and the cerebral blood flow (CBF) index which was named of perfusion index. Other variables including indexes of ICU blood gas analysis, which was consisted of variables of blood gas analysis, routine blood test and biochemistry, previous history and prognostic outcome was recorded. Binary logistic regression was used for multivariate analysis. Forty-three postoperative patients, who needed intensive care, were included. Eighteen were in delirium group and twenty-five in control group. Excluding the trauma, variables like gender, age, temperature, heart rate, respiratory rate, mean arterial pressure, acute physiology and chronic health evaluationII(APACHEII) score, organ failure, dementia and emergency surgery didn't show any statistical significance between two groups. The trauma in delirious patients increased obviously compared with the control group (33.3% vs. 4.0%, P = 0.031). Except for the brain activity [122.47 (88.62, 154.21) vs. 89.40 (86.27, 115.97), P = 0.034], there were no statistical differences in

  14. 21 CFR 330.12 - Status of over-the-counter (OTC) drugs previously reviewed under the Drug Efficacy Study (DESI).

    Science.gov (United States)

    2010-04-01

    ... may also pertain to prescription drugs): (i) Certain Surgical Sutures (DESI 4725), published in the... filing of objections. (vi) Thorexin Cough Medicine (DESI 11160) for which a notice of opportunity for... following (the referenced document may also pertain to prescription drugs): (i) Certain Sulfonamide...

  15. DEVELOPING VALUES FOR SECONDARY SCHOOL STUDENTS THROUGH THE STUDY OF ART OBJECTS

    Directory of Open Access Journals (Sweden)

    Maria Eliza Dulamă

    2011-11-01

    Full Text Available The paper begins with some issues related to aesthetics, aesthetic education, art and axiological education. The empirical research has the general assumption that secondary school students and youth have difficulties in selecting values. The objective of the research was three fold: to design, to organize and to carry learning activities from which students shall acquire educational values through the study of art objects. The exploratory research was conducted on a sample of 50 students (25 in experimental group and 25 in control group. The content sample included fairy-tales and short stories (Beauty and the Beast; The money earned by Alexandru Mitru and artistic topics on several well-known art objects (The Endless Column, Table of Silence, The Gate of Kiss, Peleş castle, Voroneţ monastery, and St. Michael’s Cathedral from Cluj-Napoca. The tested hypothesis stated that if secondary school students are involved in learning contexts where they perceive, analyze and explain artistic objects then they develop aesthetic and ethic values. The learning context students were exposed to represents the independent variable and the outputs – the educational values themselves – represent the dependent variable. In order to test for the hypothesis we planned a formative didactic experiment. In order to test the hypothesis the pre-test/post-test design was used.

  16. An Object Model for Integrating Diverse Remote Sensing Satellite Sensors: A Case Study of Union Operation

    Directory of Open Access Journals (Sweden)

    Chuli Hu

    2014-01-01

    Full Text Available In the Earth Observation sensor web environment, the rapid, accurate, and unified discovery of diverse remote sensing satellite sensors, and their association to yield an integrated solution for a comprehensive response to specific emergency tasks pose considerable challenges. In this study, we propose a remote sensing satellite sensor object model, based on the object-oriented paradigm and the Open Geospatial Consortium Sensor Model Language. The proposed model comprises a set of sensor resource objects. Each object consists of identification, state of resource attribute, and resource method. We implement the proposed attribute state description by applying it to different remote sensors. A real application, involving the observation of floods at the Yangtze River in China, is undertaken. Results indicate that the sensor inquirer can accurately discover qualified satellite sensors in an accurate and unified manner. By implementing the proposed union operation among the retrieved sensors, the inquirer can further determine how the selected sensors can collaboratively complete a specific observation requirement. Therefore, the proposed model provides a reliable foundation for sharing and integrating multiple remote sensing satellite sensors and their observations.

  17. Study on multi-objective flexible job-shop scheduling problem considering energy consumption

    Directory of Open Access Journals (Sweden)

    Zengqiang Jiang

    2014-06-01

    Full Text Available Purpose: Build a multi-objective Flexible Job-shop Scheduling Problem(FJSP optimization model, in which the makespan, processing cost, energy consumption and cost-weighted processing quality are considered, then Design a Modified Non-dominated Sorting Genetic Algorithm (NSGA-II based on blood variation for above scheduling model.Design/methodology/approach: A multi-objective optimization theory based on Pareto optimal method is used in carrying out the optimization model. NSGA-II is used to solve the model.Findings: By analyzing the research status and insufficiency of multi-objective FJSP, Find that the difference in scheduling will also have an effect on energy consumption in machining process and environmental emissions. Therefore, job-shop scheduling requires not only guaranteeing the processing quality, time and cost, but also optimizing operation plan of machines and minimizing energy consumption.Originality/value: A multi-objective FJSP optimization model is put forward, in which the makespan, processing cost, energy consumption and cost-weighted processing quality are considered. According to above model, Blood-Variation-based NSGA-II (BVNSGA-II is designed. In which, the chromosome mutation rate is determined after calculating the blood relationship between two cross chromosomes, crossover and mutation strategy of NSGA-II is optimized and the prematurity of population is overcome. Finally, the performance of the proposed model and algorithm is evaluated through a case study, and the results proved the efficiency and feasibility of the proposed model and algorithm.

  18. From Procedural to Object-Oriented Programming (OOP- Performance in OOP: An empirical study

    Directory of Open Access Journals (Sweden)

    Irene Govender

    2011-02-01

    Full Text Available This exploratory study of introductory pre- and in-service teachers’ performance in object-oriented programming (OOP assessments reveals important issues with regard to learning and teaching OOP, using java. The study is set against the backdrop of the country’s transition of its national IT curriculum from a procedural to an object-oriented programming language. The effect of prior programming experience and performances in different types of questions are examined. A combination of quantitative and qualitative methods is used to analyse the data. The effect of prior programming experience of a procedural kind and the type of assessments given is shown to have a marked influence on the performance in programming assessments and teaching of OOP. Many introductory OOP courses are in effect taught procedurally as courses in the small. Therefore educating teachers how to teach programming is a significant educational challenge. Some implications for teaching are therefore suggested

  19. Parent-child interactions and objectively measured child physical activity: a cross-sectional study

    OpenAIRE

    Hyatt Raymond R; Goldberg Jeanne P; Hughes Sheryl O; Hennessy Erin; Economos Christina D

    2010-01-01

    Abstract Background Parents influence their children's behaviors directly through specific parenting practices and indirectly through their parenting style. Some practices such as logistical and emotional support have been shown to be positively associated with child physical activity (PA) levels, while for others (e.g. monitoring) the relationship is not clear. The objectives of this study were to determine the relationship between parent's PA-related practices, general parenting style, and ...

  20. A cross-sectional study of 'yaws' in districts of Ghana which have previously undertaken azithromycin mass drug administration for trachoma control.

    Directory of Open Access Journals (Sweden)

    Rosanna Ghinai

    2015-01-01

    Full Text Available Yaws, caused by Treponema pallidum ssp. pertenue, is reportedly endemic in Ghana. Mass distribution of azithromycin is now the cornerstone of the WHO yaws eradication campaign. Mass distribution of azithromycin at a lower target dose was previously undertaken in two regions of Ghana for the control of trachoma. Ongoing reporting of yaws raises the possibility that resistance may have emerged in T. pallidum pertenue, or that alternative infections may be responsible for some of the reported cases. We conducted a cross-sectional survey in thirty communities in two districts of Ghana where MDA for trachoma had previously been conducted. Children aged 5-17 years with ulcerative lesions compatible with yaws were enrolled. Samples for treponemal serology and lesion PCR were collected from all children. 90 children with 98 lesions were enrolled. Syphilis serology was negative in all of them. PCR for T. pallidum ssp pertenue was negative in all children, but Haemophilus ducreyi DNA was detected in 9 lesions. In these communities, previously treated for trachoma, we found no evidence of ongoing transmission of yaws. H. ducreyi was associated with a proportion of skin lesions, but the majority of lesions remain unexplained. Integration of diagnostic testing into both pre and post-MDA surveillance systems is required to better inform yaws control programmes.

  1. Structuring research methods and data with the research object model: genomics workflows as a case study.

    Science.gov (United States)

    Hettne, Kristina M; Dharuri, Harish; Zhao, Jun; Wolstencroft, Katherine; Belhajjame, Khalid; Soiland-Reyes, Stian; Mina, Eleni; Thompson, Mark; Cruickshank, Don; Verdes-Montenegro, Lourdes; Garrido, Julian; de Roure, David; Corcho, Oscar; Klyne, Graham; van Schouwen, Reinout; 't Hoen, Peter A C; Bechhofer, Sean; Goble, Carole; Roos, Marco

    2014-01-01

    One of the main challenges for biomedical research lies in the computer-assisted integrative study of large and increasingly complex combinations of data in order to understand molecular mechanisms. The preservation of the materials and methods of such computational experiments with clear annotations is essential for understanding an experiment, and this is increasingly recognized in the bioinformatics community. Our assumption is that offering means of digital, structured aggregation and annotation of the objects of an experiment will provide necessary meta-data for a scientist to understand and recreate the results of an experiment. To support this we explored a model for the semantic description of a workflow-centric Research Object (RO), where an RO is defined as a resource that aggregates other resources, e.g., datasets, software, spreadsheets, text, etc. We applied this model to a case study where we analysed human metabolite variation by workflows. We present the application of the workflow-centric RO model for our bioinformatics case study. Three workflows were produced following recently defined Best Practices for workflow design. By modelling the experiment as an RO, we were able to automatically query the experiment and answer questions such as "which particular data was input to a particular workflow to test a particular hypothesis?", and "which particular conclusions were drawn from a particular workflow?". Applying a workflow-centric RO model to aggregate and annotate the resources used in a bioinformatics experiment, allowed us to retrieve the conclusions of the experiment in the context of the driving hypothesis, the executed workflows and their input data. The RO model is an extendable reference model that can be used by other systems as well. The Research Object is available at http://www.myexperiment.org/packs/428 The Wf4Ever Research Object Model is available at http://wf4ever.github.io/ro.

  2. Manipulating Objects and Telling Words: A Study on Concrete and Abstract Words Acquisition

    Science.gov (United States)

    Borghi, Anna M.; Flumini, Andrea; Cimatti, Felice; Marocco, Davide; Scorolli, Claudia

    2011-01-01

    Four experiments (E1–E2–E3–E4) investigated whether different acquisition modalities lead to the emergence of differences typically found between concrete and abstract words, as argued by the words as tools (WAT) proposal. To mimic the acquisition of concrete and abstract concepts, participants either manipulated novel objects or observed groups of objects interacting in novel ways (Training 1). In TEST 1 participants decided whether two elements belonged to the same category. Later they read the category labels (Training 2); labels could be accompanied by an explanation of their meaning. Then participants observed previously seen exemplars and other elements, and were asked which of them could be named with a given label (TEST 2). Across the experiments, it was more difficult to form abstract than concrete categories (TEST 1); even when adding labels, abstract words remained more difficult than concrete words (TEST 2). TEST 3 differed across the experiments. In E1 participants performed a feature production task. Crucially, the associations produced with the novel words reflected the pattern evoked by existing concrete and abstract words, as the first evoked more perceptual properties. In E2–E3–E4, TEST 3 consisted of a color verification task with manual/verbal (keyboard–microphone) responses. Results showed the microphone use to have an advantage over keyboard use for abstract words, especially in the explanation condition. This supports WAT: due to their acquisition modality, concrete words evoke more manual information; abstract words elicit more verbal information. This advantage was not present when linguistic information contrasted with perceptual one. Implications for theories and computational models of language grounding are discussed. PMID:21716582

  3. A Case Study in the Mars Landing Site Selection for Science Objects

    Directory of Open Access Journals (Sweden)

    Haingja Seo

    2012-12-01

    Full Text Available It is a crucial matter to select a landing site for landers or rovers in planning the Mars exploration. The landing site must have not only a scientific value as a landing site, but also geographical features to lead a safe landing for Mars probes. In this regard, this study analyzed landing site of Mars probes and rovers in previous studies and discussed the adequacy of the landing site to scientific missions. Moreover, this study also examined domestic studies on the Mars. The frameworks of these studies will guide the selection of exploration sites and a landing site when sending Mars probe to the Mars through our own efforts. Additionally, this paper will be used as the preliminary data for selection of exploration site and a landing site.

  4. The role of metacognitive skills in solving object-oriented programming problems: a case study

    Directory of Open Access Journals (Sweden)

    Marietjie Havenga

    2015-07-01

    Full Text Available This article reports on the role of metacognitive skills when solving object-oriented programming problems as part of a case study. The research was constructivist-based within an interpretivist approach to explore how four students constructed their own thinking when solving programming problems. A qualitative methodology was employed. Both concept-driven coding and data-driven coding were applied. Two main issues emerged from the findings. Participating students had fragmented knowledge of the object-oriented approach and shortcomings regarding the implementation thereof, and they experienced problems with metacognitive control during all the steps of program development. Based on the findings the use of metacognitive critical control points (MCCPs is proposed to be used as a mechanism to facilitate students in their programming efforts and to prevent loss of control during program development.

  5. Transmutation studies at CEA in frame of the SPIN program objectives, results and future trends

    Energy Technology Data Exchange (ETDEWEB)

    Salvatores, M.; Prunier, C.; Guerin, Y. [Commissariat a l`Energie Atomique, Cadarache (France)] [and others

    1995-10-01

    In order to respond to the public concern about wastes and in particular the long-lived high level ones, a French law issued on December 30, 1991 identified the major objectives of research for the next fifteen years, before a new debate and possibly a decision on final wastes disposal in Parliament. These objectives are: (1) improvement of the wastes conditioning; (2) extraction and transmutation of the long-lived wastes in order to minimize their long term toxicity; (3) research performed in underground laboratories in order to characterize the capacity of geological structures to confine radioactive wastes (two sites have to be selected for these underground laboratories, in concertation with the local population); (4) last, the study of conditioning and prolonged surface storage of wastes.

  6. Objective assessment of drowsiness and reaction time during intermittent Ramadan fasting in young men: a case-crossover study.

    Science.gov (United States)

    Bahammam, Ahmed S; Nashwan, Samar; Hammad, Omeima; Sharif, Munir M; Pandi-Perumal, Seithikurippu R

    2013-08-12

    Ramadan fasting and its attendant lifestyle changes induce changes in the circadian rhythm and in associated physiological and metabolic functions. Previous studies that have assessed psychomotor performance during Ramadan fasting have reported conflicting results. Therefore, we designed this study to objectively assess the effects of intermittent fasting during and outside Ramadan (to control for lifestyle changes) on drowsiness, blink total duration and mean reaction time (MRT) test while controlling for potential confounders. Eight healthy volunteers with a mean age of 25.3 ± 2.9 years and a mean body mass index (BMI) of 23.4 ± 3.2 kg/m2 reported to the sleep laboratory on four occasions for polysomnography (PSG) and drowsiness and psychomotor assessments as follows: 1) adaptation; 2) 4 weeks before Ramadan while performing the Islamic fasting for 1 week (baseline fasting) (BLF); 3) 1 week before Ramadan (non-fasting baseline) (BL); and 4) during the second week of Ramadan while fasting (Ramadan). OPTALERT™ was used to objectively assess daytime drowsiness using the Johns Drowsiness Scale (JDS), and blink total duration and a visual reaction time test were used to assess MRT. Rapid eye movement (REM) sleep percentage was significantly lower at BLF (17.7 ± 8.1%) and at Ramadan (18.6 ± 10.7%) compared with BL (25.6 ± 4.8%) (p intermittent fasting has no impact on drowsiness and vigilance as measured by the JDS, total blink duration and MRT.

  7. A new spectroscopic and interferometric study of the young stellar object V645 Cygni

    Science.gov (United States)

    Miroshnichenko, A. S.; Hofmann, K.-H.; Schertl, D.; Weigelt, G.; Kraus, S.; Manset, N.; Albert, L.; Balega, Y. Y.; Klochkova, V. G.; Rudy, R. J.; Lynch, D. K.; Mazuk, S.; Venturini, C. C.; Russell, R. W.; Grankin, K. N.; Puetter, R. C.; Perry, R. B.

    2009-04-01

    Aims: We present the results of high-resolution optical spectroscopy, low-resolution near-IR spectroscopy and near-infrared speckle interferometry of the massive young stellar object candidate V645 Cyg, acquired to refine its fundamental parameters and the properties of its circumstellar envelope. Methods: Speckle interferometry in the H- and K-bands and an optical spectrum in the range 5200-6680 Å with a spectral resolving power of R = 60 000 were obtained at the 6 m telescope of the Russian Academy of Sciences. Another optical spectrum in the range 4300-10 500 Å with R = 79 000 was obtained at the 3.6 m CFHT. Low-resolution spectra in the ranges 0.46-1.4 μm and 1.4-2.5 μm with R ~ 800 and ~700, respectively, were obtained at the 3 m Shane telescope of the Lick Observatory. Results: Using a novel kinematical method based on the non-linear modeling of the neutral hydrogen density profile in the direction toward the object, we propose a distance of D = 4.2 ± 0.2 kpc. We also suggest a revised estimate of the star's effective temperature, T_eff ~ 25 000 K. We resolved the object in both H- and K-bands. Using a two-component ring fit, we derived a compact component size of 14 mas and 12 mas in the H- and K-band, respectively, which correspond to 29 and 26 AU at the revised distance. Analysis of our own and previously published data indicates a ~2 mag decrease in the near-infrared brightness of V645 Cyg at the beginning of the 1980's. At the same time, the cometary nebular condensation N1 appears to fade in this wavelength range with respect to the N0 object, representing the star with a nearly pole-on optically-thick disk and an optically-thin envelope. Conclusions: We conclude that V645 Cyg is a young, massive, main-sequence star, which recently emerged from its cocoon and has already experienced its protostellar accretion stage. The presence of accretion is not necessary to account for the high observed luminosity of (2-6) × 104 M⊙ yr-1. The receding part of

  8. An investigation of clinical studies suggests those with multiple objectives should have at least 90% power for each endpoint.

    NARCIS (Netherlands)

    Borm, G.F.; Houben, R.; Welsing, P.M.J.; Zielhuis, G.A.

    2006-01-01

    BACKGROUND AND OBJECTIVES: Many clinical studies have more than one objective, either formally or informally, but this is not usually taken into account in the determination of the sample size. We investigated the overall power of a study, that is, the probability that all the objectives will be

  9. Object Persistence Enhances Spatial Navigation: A Case Study in Smartphone Vision Science.

    Science.gov (United States)

    Liverence, Brandon M; Scholl, Brian J

    2015-07-01

    Violations of spatiotemporal continuity disrupt performance in many tasks involving attention and working memory, but experiments on this topic have been limited to the study of moment-by-moment on-line perception, typically assessed by passive monitoring tasks. We tested whether persisting object representations also serve as underlying units of longer-term memory and active spatial navigation, using a novel paradigm inspired by the visual interfaces common to many smartphones. Participants used key presses to navigate through simple visual environments consisting of grids of icons (depicting real-world objects), only one of which was visible at a time through a static virtual window. Participants found target icons faster when navigation involved persistence cues (via sliding animations) than when persistence was disrupted (e.g., via temporally matched fading animations), with all transitions inspired by smartphone interfaces. Moreover, this difference occurred even after explicit memorization of the relevant information, which demonstrates that object persistence enhances spatial navigation in an automatic and irresistible fashion. © The Author(s) 2015.

  10. An object-oriented computational model to study cardiopulmonary hemodynamic interactions in humans.

    Science.gov (United States)

    Ngo, Chuong; Dahlmanns, Stephan; Vollmer, Thomas; Misgeld, Berno; Leonhardt, Steffen

    2018-06-01

    This work introduces an object-oriented computational model to study cardiopulmonary interactions in humans. Modeling was performed in object-oriented programing language Matlab Simscape, where model components are connected with each other through physical connections. Constitutive and phenomenological equations of model elements are implemented based on their non-linear pressure-volume or pressure-flow relationship. The model includes more than 30 physiological compartments, which belong either to the cardiovascular or respiratory system. The model considers non-linear behaviors of veins, pulmonary capillaries, collapsible airways, alveoli, and the chest wall. Model parameters were derisved based on literature values. Model validation was performed by comparing simulation results with clinical and animal data reported in literature. The model is able to provide quantitative values of alveolar, pleural, interstitial, aortic and ventricular pressures, as well as heart and lung volumes during spontaneous breathing and mechanical ventilation. Results of baseline simulation demonstrate the consistency of the assigned parameters. Simulation results during mechanical ventilation with PEEP trials can be directly compared with animal and clinical data given in literature. Object-oriented programming languages can be used to model interconnected systems including model non-linearities. The model provides a useful tool to investigate cardiopulmonary activity during spontaneous breathing and mechanical ventilation. Copyright © 2018 Elsevier B.V. All rights reserved.

  11. Identifying objective criterion to determine a complicated task – A comparative study

    International Nuclear Information System (INIS)

    Park, Jinkyun; Jung, Wondea

    2015-01-01

    Highlights: • Reliable estimation on the likelihood of human error is very critical. • Still there is no clear and objective criterion on a complicated task. • Subjective difficulty scores rated by 75 high speed train drivers are collected. • Collected difficulty scores are compared with the associated TACOM scores. • Criteria for task complexity level seem to be determined by the TACOM measure. - Abstract: A reliable estimation on the likelihood of human error is very critical for evaluating the safety of a large process control system such as NPPs (Nuclear Power Plants). In this regard, one of the determinants is to decide the level of an important PSF (Performance Shaping Factor) through a clear and objective manner along with the context of a given task. Unfortunately, it seems that there are no such decision criteria for certain PSFs including the complexity of a task. Therefore, the feasibility of the TACOM (Task Complexity) measure in providing objective criteria that are helpful for distinguishing the level of a task complexity is investigated in this study. To this end, subjective difficulty scores rated by 75 high-speed train drivers are collected for 38 tasks. After that, subjective difficulty scores are compared with the associated TACOM scores being quantified based on these tasks. As a result, it is observed that there is a significant correlation between subjective difficulty scores rated by high-speed train drivers and the associated TACOM scores. Accordingly, it is promising to expect that the TACOM measure can be used as an objective tool to identify the level of a task complexity in terms of an HRA (Human Reliability Analysis)

  12. An objective evaluation framework for segmentation techniques of functional positron emission tomography studies

    CERN Document Server

    Kim, J; Eberl, S; Feng, D

    2004-01-01

    Segmentation of multi-dimensional functional positron emission tomography (PET) studies into regions of interest (ROI) exhibiting similar temporal behavior is useful in diagnosis and evaluation of neurological images. Quantitative evaluation plays a crucial role in measuring the segmentation algorithm's performance. Due to the lack of "ground truth" available for evaluating segmentation of clinical images, automated segmentation results are usually compared with manual delineation of structures which is, however, subjective, and is difficult to perform. Alternatively, segmentation of co-registered anatomical images such as magnetic resonance imaging (MRI) can be used as the ground truth to the PET segmentation. However, this is limited to PET studies which have corresponding MRI. In this study, we introduce a framework for the objective and quantitative evaluation of functional PET study segmentation without the need for manual delineation or registration to anatomical images of the patient. The segmentation ...

  13. Treatment of advanced, recurrent, resistant to previous treatments basal and squamous cell skin carcinomas with a synergistic formulation of interferons. Open, prospective study

    Directory of Open Access Journals (Sweden)

    Lopez-Saura Pedro

    2009-07-01

    Full Text Available Abstract Background Aggressive non-melanoma skin cancer (deeply infiltrating, recurrent, and morphea form lesions are therapeutically challenging because they require considerable tissue loss and may demand radical disfiguring surgery. Interferons (IFN may provide a non-surgical approach to the management of these tumors. The aim of this work was to evaluate the effect of a formulation containing IFNs-α and -γ in synergistic proportions on patients with recurrent, advanced basal cell (BCC or squamous cell skin carcinomas (SCSC. Methods Patients with extensive, recurrent, resistant to other procedures BCC or SCSC received the IFN formulation peri- and intralesionally, three times per week for 3 weeks. They had been previously treated with surgery and/or radiotherapy or chemotherapy. Thirteen weeks after the end of treatment, the original lesion sites were examined for histological evidence of remaining tumor. Results Sixteen elder (median 70 years-old patients were included. They beared 12 BCC and 4 SCSC ranging from 1.5 to 12.5 cm in the longest dimension. At the end of treatment 47% CR (complete tumor elimination, 40% PR (>30% tumor reduction, and 13% stable disease were obtained. None of the patients relapsed during the treatment period. The median duration of the response was 38 months. Only one patient with complete response had relapsed until today. Principal adverse reactions were influenza-like symptoms well known to occur with interferon therapy, which were well tolerated. Conclusion The peri- and intralesional combination of IFNs-α and -γ was safe and showed effect for the treatment of advanced, recurrent and resistant to previous treatments of BCC and SCSC in elder patients. This is the first report of such treatment in patients with advance non-melanoma skin cancer. The encouraging result justifies further confirmatory trials. Trial registration Current Controlled Trials RPCEC00000052.

  14. Treatment of advanced, recurrent, resistant to previous treatments basal and squamous cell skin carcinomas with a synergistic formulation of interferons. Open, prospective study

    International Nuclear Information System (INIS)

    Anasagasti-Angulo, Lorenzo; Garcia-Vega, Yanelda; Barcelona-Perez, Silvia; Lopez-Saura, Pedro; Bello-Rivero, Iraldo

    2009-01-01

    Aggressive non-melanoma skin cancer (deeply infiltrating, recurrent, and morphea form lesions) are therapeutically challenging because they require considerable tissue loss and may demand radical disfiguring surgery. Interferons (IFN) may provide a non-surgical approach to the management of these tumors. The aim of this work was to evaluate the effect of a formulation containing IFNs-α and -γ in synergistic proportions on patients with recurrent, advanced basal cell (BCC) or squamous cell skin carcinomas (SCSC). Patients with extensive, recurrent, resistant to other procedures BCC or SCSC received the IFN formulation peri- and intralesionally, three times per week for 3 weeks. They had been previously treated with surgery and/or radiotherapy or chemotherapy. Thirteen weeks after the end of treatment, the original lesion sites were examined for histological evidence of remaining tumor. Sixteen elder (median 70 years-old) patients were included. They beared 12 BCC and 4 SCSC ranging from 1.5 to 12.5 cm in the longest dimension. At the end of treatment 47% CR (complete tumor elimination), 40% PR (>30% tumor reduction), and 13% stable disease were obtained. None of the patients relapsed during the treatment period. The median duration of the response was 38 months. Only one patient with complete response had relapsed until today. Principal adverse reactions were influenza-like symptoms well known to occur with interferon therapy, which were well tolerated. The peri- and intralesional combination of IFNs-α and -γ was safe and showed effect for the treatment of advanced, recurrent and resistant to previous treatments of BCC and SCSC in elder patients. This is the first report of such treatment in patients with advance non-melanoma skin cancer. The encouraging result justifies further confirmatory trials. Current Controlled Trials RPCEC00000052

  15. Objective Sleep Structure and Cardiovascular Risk Factors in the General Population: The HypnoLaus Study

    Science.gov (United States)

    Haba-Rubio, José; Marques-Vidal, Pedro; Andries, Daniela; Tobback, Nadia; Preisig, Martin; Vollenweider, Peter; Waeber, Gérard; Luca, Gianina; Tafti, Mehdi; Heinzer, Raphaël

    2015-01-01

    Study Objectives: To evaluate the association between objective sleep measures and metabolic syndrome (MS), hypertension, diabetes, and obesity. Design: Cross-sectional study. Setting: General population sample. Participants: There were 2,162 patients (51.2% women, mean age 58.4 ± 11.1). Interventions: Patients were evaluated for hypertension, diabetes, overweight/obesity, and MS, and underwent a full polysomnography (PSG). Measurements and Results: PSG measured variables included: total sleep time (TST), percentage and time spent in slow wave sleep (SWS) and in rapid eye movement (REM) sleep, sleep efficiency and arousal index (ArI). In univariate analyses, MS was associated with decreased TST, SWS, REM sleep, and sleep efficiency, and increased ArI. After adjustment for age, sex, smoking, alcohol, physical activity, drugs that affect sleep and depression, the ArI remained significantly higher, but the difference disappeared in patients without significant sleep disordered breathing (SDB). Differences in sleep structure were also found according to the presence or absence of hypertension, diabetes, and overweight/obesity in univariate analysis. However, these differences were attenuated after multivariate adjustment and after excluding subjects with significant SDB. Conclusions: In this population-based sample we found significant associations between sleep structure and metabolic syndrome (MS), hypertension, diabetes, and obesity. However, these associations were cancelled after multivariate adjustment. We conclude that normal variations in sleep contribute little if any to MS and associated disorders. Citation: Haba-Rubio J, Marques-Vidal P, Andries D, Tobback N, Preisig M, Vollenweider P, Waeber G, Luca G, Tafti M, Heinzer R. Objective sleep structure and cardiovascular risk factors in the general population: the HypnoLaus study. SLEEP 2015;38(3):391–400. PMID:25325467

  16. Object and Objective Lost?

    DEFF Research Database (Denmark)

    Lopdrup-Hjorth, Thomas

    2015-01-01

    This paper explores the erosion and problematization of ‘the organization’ as a demarcated entity. Utilizing Foucault's reflections on ‘state-phobia’ as a source of inspiration, I show how an organization-phobia has gained a hold within Organization Theory (OT). By attending to the history...... of this organization-phobia, the paper argues that OT has become increasingly incapable of speaking about its core object. I show how organizations went from being conceptualized as entities of major importance to becoming theoretically deconstructed and associated with all kinds of ills. Through this history......, organizations as distinct entities have been rendered so problematic that they have gradually come to be removed from the center of OT. The costs of this have been rather significant. Besides undermining the grounds that gave OT intellectual credibility and legitimacy to begin with, the organization-phobia...

  17. Objective and Subjective Responses to Low Relative Humidity in an Office Intervention Study

    DEFF Research Database (Denmark)

    Lagercrantz, Love Per; Wyon, David; Meyer, H. W.

    2003-01-01

    and objective (clinical) measurements were applied. The following effects of increased humidity were significant, though small: the air was evaluated as less dry (though still on the dry side of neutral), eyes smarted less (by 10% of full scale) eye irritation decreased (by 11%), symptoms of dry throat, mouth......The impact of dry indoor air on comfort and health in winter was investigated in a crossover intervention study in two floors of an office building in northern Sweden. The indoor air humidity (normally 10-20% RH) was raised to 23-24% RH, one floor at a time, using steam humidifiers. Questionnaires...

  18. Can methodological requirements be fulfilled when studying concealed or unethical research objects? The case of astroturfing

    Directory of Open Access Journals (Sweden)

    Sophie BOULAY

    2013-12-01

    Full Text Available Scientific soundness is key in the development of research designs. Methodological choices bear the responsibility to demonstrate its obtainment. However, it is challenging to abide by these standards while dealing with hidden, masked or unethical objects. In this article, we share the various strategies employed to aim at a sound scientific process in spite of astroturfing’s characteristics and of the methodological orientations it dictates. Facing the dilemma between the importance of scientific value and the richness of inductive and exploratory approaches, we question the influence of positivist research standards in communication studies. We fear these requirements may limit their development.

  19. Performance Study of Objective Speech Quality Measurement for Modern Wireless-VoIP Communications

    Directory of Open Access Journals (Sweden)

    Chan Wai-Yip

    2009-01-01

    Full Text Available Wireless-VoIP communications introduce perceptual degradations that are not present with traditional VoIP communications. This paper investigates the effects of such degradations on the performance of three state-of-the-art standard objective quality measurement algorithms—PESQ, P.563, and an "extended" E-model. The comparative study suggests that measurement performance is significantly affected by acoustic background noise type and level as well as speech codec and packet loss concealment strategy. On our data, PESQ attains superior overall performance and P.563 and E-model attain comparable performance figures.

  20. [The effect of acupuncture in the treatment of insomnia. Clinical study of subjective and objective evaluation].

    Science.gov (United States)

    Montakab, H; Langel, G

    1994-01-01

    The sleep-wake cycle is the most important circadian rhythm in man and thus constitutes an excellent indicator of internal equilibrium and of health. Sleep disorders, and particularly insomnia, affect a great percentage of the population. In daily practice, an inappropriate treatment may transform a bad sleeper into an insomniac dependent on pharmaceuticals for life. It is therefore necessary to give priority to non-chemical treatments in the management of insomnia. Acupuncture, which offers a personalized treatment, is particularly indicated for reharmonizing a disturbed sleep-wake cycle. Furthermore, there is an interesting similarity between the 5000-year-old theoretical basis of Chinese medicine and the recent scientific discoveries about man's internal rhythms. Clinical and statistical studies of the effects of acupuncture on insomnia are rare and evaluate only the subjective appreciation of sleep. Objective analysis of sleep by polysomnography permits evaluation of sleep architecture and visualizes the site and depth of action of the therapeutic method. Such studies have only been conducted in relation to pharmaceutical treatments. No such study has been carried out for acupuncture. A scientific and objective evaluation of the effects of acupuncture on insomnia by polysomnography could be not only of academic but mainly of great practical interest. If the efficiency of acupuncture is thus verified, this method could be integrated and proposed along with other classical therapeutic technics.

  1. Bats and Academics: How Do Scientists Perceive Their Object of Study?

    Science.gov (United States)

    Boëte, Christophe; Morand, Serge

    2016-01-01

    Bats are associated with conflicting perceptions among humans, ranging from affection to disgust. If these attitudes can be associated with various factors among the general public (e.g. social norms, lack of knowledge), it is also important to understand the attitude of scientists who study bats. Such reflexive information on the researchers community itself could indeed help designing adequate mixed communication tools aimed at protecting bats and their ecosystems, as well as humans living in their vicinity that could be exposed to their pathogens. Thus, we conducted an online survey targeting researchers who spend a part of their research activity studying bats. Our aim was to determine (1) how they perceive their object of study, (2) how they perceive the representation of bats in the media and by the general population, (3) how they protect themselves against pathogen infections during their research practices, and (4) their perceptions of the causes underlying the decline in bat populations worldwide. From the 587 completed responses (response rate of 28%) having a worldwide distribution, the heterogeneity of the scientists' perception of their own object of study was highlighted. In the majority of cases, this depended on the type of research they conducted (i.e. laboratory versus field studies) as well as their research speciality. Our study revealed a high level of personal protection equipment being utilised against pathogens during scientific practices, although the role bats play as reservoirs for a number of emerging pathogens remains poorly known. Our results also disclosed the unanimity among specialists in attributing a direct role for humans in the global decline of bat populations, mainly via environmental change, deforestation, and agriculture intensification. Overall, the present study suggests the need for better communication regarding bats and their biology, their role within the scientific community, as well as in the general public

  2. Bats and Academics: How Do Scientists Perceive Their Object of Study?

    Directory of Open Access Journals (Sweden)

    Christophe Boëte

    Full Text Available Bats are associated with conflicting perceptions among humans, ranging from affection to disgust. If these attitudes can be associated with various factors among the general public (e.g. social norms, lack of knowledge, it is also important to understand the attitude of scientists who study bats. Such reflexive information on the researchers community itself could indeed help designing adequate mixed communication tools aimed at protecting bats and their ecosystems, as well as humans living in their vicinity that could be exposed to their pathogens. Thus, we conducted an online survey targeting researchers who spend a part of their research activity studying bats. Our aim was to determine (1 how they perceive their object of study, (2 how they perceive the representation of bats in the media and by the general population, (3 how they protect themselves against pathogen infections during their research practices, and (4 their perceptions of the causes underlying the decline in bat populations worldwide. From the 587 completed responses (response rate of 28% having a worldwide distribution, the heterogeneity of the scientists' perception of their own object of study was highlighted. In the majority of cases, this depended on the type of research they conducted (i.e. laboratory versus field studies as well as their research speciality. Our study revealed a high level of personal protection equipment being utilised against pathogens during scientific practices, although the role bats play as reservoirs for a number of emerging pathogens remains poorly known. Our results also disclosed the unanimity among specialists in attributing a direct role for humans in the global decline of bat populations, mainly via environmental change, deforestation, and agriculture intensification. Overall, the present study suggests the need for better communication regarding bats and their biology, their role within the scientific community, as well as in the general

  3. Object-Based Greenhouse Horticultural Crop Identification from Multi-Temporal Satellite Imagery: A Case Study in Almeria, Spain

    Directory of Open Access Journals (Sweden)

    Manuel A. Aguilar

    2015-06-01

    Full Text Available Greenhouse detection and mapping via remote sensing is a complex task, which has already been addressed in numerous studies. In this research, the innovative goal relies on the identification of greenhouse horticultural crops that were growing under plastic coverings on 30 September 2013. To this end, object-based image analysis (OBIA and a decision tree classifier (DT were applied to a set consisting of eight Landsat 8 OLI images collected from May to November 2013. Moreover, a single WorldView-2 satellite image acquired on 30 September 2013, was also used as a data source. In this approach, basic spectral information, textural features and several vegetation indices (VIs derived from Landsat 8 and WorldView-2 multi-temporal satellite data were computed on previously segmented image objects in order to identify four of the most popular autumn crops cultivated under greenhouse in Almería, Spain (i.e., tomato, pepper, cucumber and aubergine. The best classification accuracy (81.3% overall accuracy was achieved by using the full set of Landsat 8 time series. These results were considered good in the case of tomato and pepper crops, being significantly worse for cucumber and aubergine. These results were hardly improved by adding the information of the WorldView-2 image. The most important information for correct classification of different crops under greenhouses was related to the greenhouse management practices and not the spectral properties of the crops themselves.

  4. [Culinary as an object of study and intervention in the field of Food and Nutrition].

    Science.gov (United States)

    Diez-Garcia, Rosa Wanda; de Castro, Inês Rugani Ribeiro

    2011-01-01

    Culinary is approached here as an object of food and nutritional studies and interventions aimed at dietary changes. In order to explore the culinary potential, two studies are presented: one qualitative, focusing on dietary intake, with subjects from two socioeconomic sectors submitted to salt restrictions; the other uses cooking as structural axis of an educational method for promoting healthy eating. In both studies one can observe the potential of culinary: in the first, as a medium which allows access to information about food procedures that can improve the quality of information about food intake and food practices and, in the second, as an effective space for interventions aimed at food habit changes by addressing their sensorial, cognitive, symbolic and procedural dimensions.

  5. Metallic objects belonging to the first emperor of Brazil studied with PIXE technique

    Energy Technology Data Exchange (ETDEWEB)

    Ambiel, V.C. [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). Museu de Arqueologia e Etnologia; Rizzutto, M.A.; Curado, J.F.; Campos, P.H.O.V.; Kajiya, E.A.M.; Silva, T.F., E-mail: rizzutto@if.usp.br [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). lnstituto de Fisica

    2013-07-01

    Full text: First Emperor of Brazil, D. Pedro I is one of the main personalities in the history of Brazil and was responsible for the formation of the 'Brazilian nation', in September 7. With the death of King D. Joao VI in 1826, was acclaimed King Pedro IV in Portugal, however, held the office for a week and abdicated in favor of her daughter, Maria da Gloria. Due to political problems he also abdicated the Brazilian throne, in 1831, in favor of his son Pedro II. D. Pedro died on September 24 of 1834 at the Palace of Queluz, in Cintra and was buried in the Pantheon of the Royal House of Braganca, in Lisbon, Portugal. However in 1972, during celebrations of the 150{sup th} anniversary of the Independence of Brazil, his remains were moved to the Imperial Chapel in Monument Ipiranga installed in the city of Sao Paulo, Brazil. In the year 2012, was initiated a study in the Emperor including the exhumation, the inventory associated with it and several physical-chemical studies. The analyses have been performed with non-destructive techniques such as X-Ray Fluorescence (XRF) in various classes of objects, including bones, tissues and metals and also Particle Induced X-Ray Emission (PIXE) in the metal objects. This article presents the PIXE results obtained for the set of metallic artifacts such as cufflinks and medals that show a wide variation in chemical composition with alloys formed mainly of copper and zinc and also made of alloys containing silver and gold. It was also verified the presence of lead and calcium, probably due to contamination suffered in the environment in which materials were found, particularly the remains were originally kept in a coffin of lead. The analyses also indicate some degree of deterioration of these objects. (author)

  6. Metallic objects belonging to the first emperor of Brazil studied with PIXE technique

    International Nuclear Information System (INIS)

    Ambiel, V.C.; Rizzutto, M.A.; Curado, J.F.; Campos, P.H.O.V.; Kajiya, E.A.M.; Silva, T.F.

    2013-01-01

    Full text: First Emperor of Brazil, D. Pedro I is one of the main personalities in the history of Brazil and was responsible for the formation of the 'Brazilian nation', in September 7. With the death of King D. Joao VI in 1826, was acclaimed King Pedro IV in Portugal, however, held the office for a week and abdicated in favor of her daughter, Maria da Gloria. Due to political problems he also abdicated the Brazilian throne, in 1831, in favor of his son Pedro II. D. Pedro died on September 24 of 1834 at the Palace of Queluz, in Cintra and was buried in the Pantheon of the Royal House of Braganca, in Lisbon, Portugal. However in 1972, during celebrations of the 150 th anniversary of the Independence of Brazil, his remains were moved to the Imperial Chapel in Monument Ipiranga installed in the city of Sao Paulo, Brazil. In the year 2012, was initiated a study in the Emperor including the exhumation, the inventory associated with it and several physical-chemical studies. The analyses have been performed with non-destructive techniques such as X-Ray Fluorescence (XRF) in various classes of objects, including bones, tissues and metals and also Particle Induced X-Ray Emission (PIXE) in the metal objects. This article presents the PIXE results obtained for the set of metallic artifacts such as cufflinks and medals that show a wide variation in chemical composition with alloys formed mainly of copper and zinc and also made of alloys containing silver and gold. It was also verified the presence of lead and calcium, probably due to contamination suffered in the environment in which materials were found, particularly the remains were originally kept in a coffin of lead. The analyses also indicate some degree of deterioration of these objects. (author)

  7. Diurnal rhythm and concordance between objective and subjective hot flashes: the Hilo Women's Health Study.

    Science.gov (United States)

    Sievert, Lynnette L; Reza, Angela; Mills, Phoebe; Morrison, Lynn; Rahberg, Nichole; Goodloe, Amber; Sutherland, Michael; Brown, Daniel E

    2010-01-01

    The aims of this study were to test for a diurnal pattern in hot flashes in a multiethnic population living in a hot, humid environment and to examine the rates of concordance between objective and subjective measures of hot flashes using ambulatory and laboratory measures. Study participants aged 45 to 55 years were recruited from the general population of Hilo, HI. Women wore a Biolog hot flash monitor (UFI, Morro Bay, CA), kept a diary for 24 hours, and also participated in 3-hour laboratory measures (n = 199). Diurnal patterns were assessed using polynomial regression. For each woman, objectively recorded hot flashes that matched subjective experience were treated as true-positive readings. Subjective hot flashes were considered the standard for computing false-positive and false-negative readings. True-positive, false-positive, and false-negative readings were compared across ethnic groups by chi analyses. Frequencies of sternal, nuchal, and subjective hot flashes peaked at 1500 +/- 1 hours with no difference by ethnicity. Laboratory results supported the pattern seen in ambulatory monitoring. Sternal and nuchal monitoring showed the same frequency of true-positive measures, but nonsternal electrodes picked up more false-positive readings. Laboratory monitoring showed very low frequencies of false negatives. There were no ethnic differences in the frequency of true-positive or false-positive measures. Women of European descent were more likely to report hot flashes that were not objectively demonstrated (false-negative measures). The diurnal pattern and peak in hot flash occurrence in the hot humid environment of Hilo were similar to results from more temperate environments. Lack of variation in sternal versus nonsternal measures and in true-positive measures across ethnicities suggests no appreciable effect of population variation in sweating patterns.

  8. The impact of differences between subjective and objective social class on life satisfaction among the Korean population in early old age: Analysis of Korean longitudinal study on aging.

    Science.gov (United States)

    Choi, Young; Kim, Jae-Hyun; Park, Eun-Cheol

    2016-01-01

    Several previous studies have established the relationship between the effects of socioeconomic status or subjective social strata on life satisfaction. However, no previous study has examined the relationship between social class and life satisfaction in terms of a disparity between subjective and objective social status. To investigate the relationship between differences in subjective and objective social class and life satisfaction. Data from the Korean Longitudinal Study of Aging with 8252 participants aged 45 or older was used. Life satisfaction was measured by the question, "How satisfied are you with your quality of life?" The main independent variable was differences in objective (income and education) and subjective social class, which was classified according to nine categories (ranging from high-high to low-low). This association was investigated by linear mixed model due to two waves data nested within individuals. Lower social class (income, education, subjective social class) was associated with dissatisfaction. The impact of objective and subjective social class on life satisfaction varied according to the level of differences in objective and subjective social class. Namely, an individual's life satisfaction declined as objective social classes decreased at the same level of subjective social class (i.e., HH, MH, LH). In both dimensions of objective social class (education and income), an individual's life satisfaction declined as subjective social class decreased by one level (i.e., HH, HM, HL). Our findings indicated that social supports is needed to improve the life satisfaction among the population aged 45 or more with low social class. The government should place increased focus on policies that encourage not only the life satisfaction of the Korean elderly with low objective social class, but also subjective social class. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  9. Subjective sleep complaints indicate objective sleep problems in psychosomatic patients: a prospective polysomnographic study

    Directory of Open Access Journals (Sweden)

    Linden M

    2016-08-01

    Full Text Available Michael Linden,1,2 Marie Dietz,1 Christian Veauthier,3 Ingo Fietze3 1Research Group Psychosomatic Rehabilitation, Charité University Medicine Berlin, 2Department of Psychosomatic Medicine, Rehabilitation Centre Seehof, Teltow, 3Interdisciplinary Center of Sleep Medicine, Charité University Medicine Berlin, Berlin, Germany Objective: To elucidate the relationship between subjective complaints and polysomnographical parameters in psychosomatic patients.Method: A convenience sample of patients from a psychosomatic inpatient unit were classified according to the Pittsburgh Sleep Quality Index (PSQI as very poor sleepers (PSQI >10, n=80 and good sleepers (PSQI <6, n=19. They then underwent a polysomnography and in the morning rated their previous night’s sleep using a published protocol (Deutschen Gesellschaft für Schlafforschung und Schlafmedizin morning protocol [MP].Results: In the polysomnography, significant differences were found between very poor and good sleepers according to the PSQI with respect to sleep efficiency and time awake after sleep onset. When comparing objective PSG and subjective MP, the polysomnographical sleep onset latency was significantly positively correlated with the corresponding parameters of the MP: the subjective sleep onset latency in minutes and the subjective evaluation of sleep onset latency (very short, short, normal, long, very long were positively correlated with the sleep latency measured by polysomnography. The polysomnographical time awake after sleep onset (in minutes was positively correlated with the subjective time awake after sleep onset (in minutes, evaluation of time awake after sleep onset (seldom, normal often, and subjective restfulness. The polysomnographical total sleep time (TST was positively correlated with the subjective TST. Conversely, the polysomnographical TST was negatively correlated with the evaluation of TST (high polysomnographical TST was correlated with the subjective

  10. Prognostic factors in multiple myeloma: definition of risk groups in 410 previously untreated patients: a Grupo Argentino de Tratamiento de la Leucemia Aguda study.

    Science.gov (United States)

    Corrado, C; Santarelli, M T; Pavlovsky, S; Pizzolato, M

    1989-12-01

    Four hundred ten previously untreated multiple myeloma patients entered onto two consecutive Grupo Argentino de Tratamiento de la Leucemia Aguda (GATLA) protocols were analyzed to identify significant prognostic factors influencing survival. The univariate analysis selected the following variables: performance status, renal function, percentage of bone marrow plasma cells at diagnosis, hemoglobin, and age. A multivariate analysis showed that performance status, renal function, percentage of bone marrow plasma cells, hemoglobin, and age were the best predictive variables for survival. A score was assigned to each patient according to these variables, which led to their classification in three groups: good, intermediate, and poor risk, with a probability of survival of 26% and 10% at 96 months, and 5% at 56 months, and median survival of 60, 37, and 14 months, respectively (P = .0000). In our patient population, this model proved to be superior to the Durie-Salmon staging system in defining prognostic risk groups, and separating patients with significantly different risks within each Durie-Salmon stage.

  11. Implementation of an electronic medical record system in previously computer-naïve primary care centres: a pilot study from Cyprus.

    Science.gov (United States)

    Samoutis, George; Soteriades, Elpidoforos S; Kounalakis, Dimitris K; Zachariadou, Theodora; Philalithis, Anastasios; Lionis, Christos

    2007-01-01

    The computer-based electronic medical record (EMR) is an essential new technology in health care, contributing to high-quality patient care and efficient patient management. The majority of southern European countries, however, have not yet implemented universal EMR systems and many efforts are still ongoing. We describe the development of an EMR system and its pilot implementation and evaluation in two previously computer-naïve public primary care centres in Cyprus. One urban and one rural primary care centre along with their personnel (physicians and nurses) were selected to participate. Both qualitative and quantitative evaluation tools were used during the implementation phase. Qualitative data analysis was based on the framework approach, whereas quantitative assessment was based on a nine-item questionnaire and EMR usage parameters. Two public primary care centres participated, and a total often health professionals served as EMR system evaluators. Physicians and nurses rated EMR relatively highly, while patients were the most enthusiastic supporters for the new information system. Major implementation impediments were the physicians' perceptions that EMR usage negatively affected their workflow, physicians' legal concerns, lack of incentives, system breakdowns, software design problems, transition difficulties and lack of familiarity with electronic equipment. The importance of combining qualitative and quantitative evaluation tools is highlighted. More efforts are needed for the universal adoption and routine use of EMR in the primary care system of Cyprus as several barriers to adoption exist; however, none is insurmountable. Computerised systems could improve efficiency and quality of care in Cyprus, benefiting the entire population.

  12. Prospective monitoring and self-report of previous falls among older women at high risk of falls and fractures: a study of comparison and agreement.

    Science.gov (United States)

    Garcia, Patrícia A; Dias, João M D; Silva, Silvia L A; Dias, Rosângela C

    2015-01-01

    The identification of the occurrence of falls is an important step for screening and for rehabilitation processes for the elderly. The methods of monitoring these events are susceptible to recording biases, and the choice of the most accurate method remains challenging. (i) To investigate the agreement between retrospective self-reporting and prospective monitoring of methods of recording falls, and (ii) to compare the retrospective self-reporting of falls and the prospective monitoring of falls and recurrent falls over a 12-month period among older women at high risk of falls and fractures. A total of 118 community-dwelling older women with low bone density were recruited. The incidence of falls was monitored prospectively in 116 older women (2 losses) via monthly phone calls over the course of a year. At the end of this monitoring period, the older women were asked about their recall of falls in the same 12-month period. The agreement between the two methods was analyzed, and the sensitivity and specificity of self-reported previous falls in relation to the prospective monitoring were calculated. There was moderate agreement between the prospective monitoring and the retrospective self-reporting of falls in classifying fallers (Kappa = 0.595) and recurrent fallers (Kappa = 0.589). The limits of agreement were 0.35 ± 1.66 falls. The self-reporting of prior falls had a 67.2% sensitivity and a 94.2% specificity in classifying fallers among older women and a 50% sensitivity and a 98.9% specificity in classifying recurrent fallers. Self-reporting of falls over a 12-month period underestimated 32.8% of falls and 50% of recurrent falls. The findings recommend caution if one is considering replacing monthly monitoring with annual retrospective questioning.

  13. The importance of continued exercise participation in quality of life and psychological well-being in previously inactive postmenopausal women: a pilot study.

    Science.gov (United States)

    Asbury, Elizabeth A; Chandrruangphen, Pornpat; Collins, Peter

    2006-01-01

    Exercise and physical activity provide a wide range of health benefits for postmenopausal women, although the impact of maintained exercise participation on psychological well-being is unclear. An exploration of continued exercise participation in psychological well-being after a moderate-intensity exercise program in previously inactive postmenopausal women was therefore undertaken. : Twenty-three healthy sedentary postmenopausal women (age 56 +/- 4 years) were randomly assigned to two groups. All participants completed the Short Form-36, Hospital Anxiety and Depression Scale (HADS), and Health Anxiety Questionnaire (HAQ) and then began a 6-week walking program at 50% heart rate reserve defined by (.-)V(O(2)) treadmill testing. Post-intervention, all participants underwent (.-)V(O(2)) treadmill testing and questionnaires. Group 1 was then instructed to continue exercising, whereas group 2 was instructed to desist for an additional 6-week period. On completion of the 6-week follow-up, participants completed a final set of questionnaires. Participants performed 97% of the prescribed 15-hour (900 minute) exercise program (875.1 +/- 177.4 minutes) in an average of 26 +/- 5 sessions. Total HAQ (P = 0.001), health worry (P = 0.001), fear of illness (P = 0.037), reassurance seeking behavior (P = 0.037), SF-36 well-being (P = 0.037), total HADS (P = 0.019), and HADS depression (P = 0.015) improved significantly following the exercise program. At follow-up, group 1 had lower HADS anxiety (P = 0.013), total HADS (P = 0.02), total HAQ (P = 0.03), and HAQ interference with life (P = 0.03) and significantly higher SF-36 energy (P = 0.01) than group 2. Healthy postmenopausal women gain significant psychological benefit from moderate-intensity exercise. However, exercise participation must continue to maintain improvements in psychological well-being and quality of life.

  14. Outsourcing and its impact on operational objectives and performance: a study of Iranian telecommunication industries

    Directory of Open Access Journals (Sweden)

    Amir Reza Khaki

    2012-01-01

    Full Text Available Through outsourcing, a company can expand and develop its sources and capacities by accessing to higher quality services and better functionality. This paper deals with the perception of the managers of the telecommunication industry sector on the effects of outsourcing on operational strategy and especially on the issues associated with cost reduction, developed quality, flexibility and better service. Because of the importance of the strategic feature of outsourcing, we examined its effects on the organizational function of the telecommunication industries. This study shows that managers believe that outsourcing has a great impact not only on the cost reduction but also on other goals of operational strategies, which makes outsourcing become inherently more strategic. In addition, it seems that outsourcing influences function noticeably. In the present research, the relationships between propensity to outsourcing and operational objectives and organizational performance in telecommunication industries are assessed. The aim of this research is to examine the propensity to outsourcing and its impacts on operational objectives including cost reduction, improved quality, flexibility and better service and organizational performance, which includes financial performance and non-financial performance. In the research, data are collected through field research and questionnaires. The questionnaires are distributed among the board of directors, quality managers, operational administrators, and lower managers and then the feedbacks are analyzed using SPSS and Minitab software based on deductive and descriptive statistics.

  15. Kids'Cam: An Objective Methodology to Study the World in Which Children Live.

    Science.gov (United States)

    Signal, Louise N; Smith, Moira B; Barr, Michelle; Stanley, James; Chambers, Tim J; Zhou, Jiang; Duane, Aaron; Jenkin, Gabrielle L S; Pearson, Amber L; Gurrin, Cathal; Smeaton, Alan F; Hoek, Janet; Ni Mhurchu, Cliona

    2017-09-01

    This paper reports on a new methodology to objectively study the world in which children live. The primary research study (Kids'Cam Food Marketing) illustrates the method; numerous ancillary studies include exploration of children's exposure to alcohol, smoking, "blue" space and gambling, and their use of "green" space, transport, and sun protection. One hundred sixty-eight randomly selected children (aged 11-13 years) recruited from 16 randomly selected schools in Wellington, New Zealand used wearable cameras and GPS units for 4 days, recording imagery every 7 seconds and longitude/latitude locations every 5 seconds. Data were collected from July 2014 to June 2015. Analysis commenced in 2015 and is ongoing. Bespoke software was used to manually code images for variables of interest including setting, marketing media, and product category to produce variables for statistical analysis. GPS data were extracted and cleaned in ArcGIS, version 10.3 for exposure spatial analysis. Approximately 1.4 million images and 2.2 million GPS coordinates were generated (most were usable) from many settings including the difficult to measure aspects of exposures in the home, at school, and during leisure time. The method is ethical, legal, and acceptable to children and the wider community. This methodology enabled objective analysis of the world in which children live. The main arm examined the frequency and nature of children's exposure to food and beverage marketing and provided data on difficult to measure settings. The methodology will likely generate robust evidence facilitating more effective policymaking to address numerous public health concerns. Copyright © 2017. Published by Elsevier Inc.

  16. Pilot study on objective measurement of abdominal wall strength in patients with ventral incisional hernia.

    Science.gov (United States)

    Parker, Michael; Goldberg, Ross F; Dinkins, Maryane M; Asbun, Horacio J; Daniel Smith, C; Preissler, Susanne; Bowers, Steven P

    2011-11-01

    Outcomes after ventral incisional hernia (VIH) repair are measured by recurrence rate and subjective measures. No objective metrics evaluate functional outcomes after abdominal wall reconstruction. This study aimed to develop testing of abdominal wall strength (AWS) that could be validated as a useful metric. Data were prospectively collected during 9 months from 35 patients. A total of 10 patients were evaluated before and after VIH repair, for a total of 45 encounters. The patients were tested simultaneously or in succession by two of three examiners. Data were collected for three tests: double leg lowering (DLL), trunk raising (TR), and supine reaching (SR). Raw data were compared and tested for validity, and continuous data were transformed to categorical data. Agreement was measured using the intraclass correlation coefficient (ICC) for DLL and using kappa for the ordinal measures. Simultaneous testing yielded the following interobserver reliability: DLL (0.96 and 0.87), TR (1.00 and 0.95), and SR (0.76). Reproducibility was assessed by consecutive tests, with correlation as follows: DLL (0.81), TR (0.81), and RCH (0.21). Due to poor interobserver reliability for the SR test compared with the DLL and TR tests, the SR test was excluded from calculation of an overall score. Based on raw data distribution from the DLL and TR tests, the DLL data were categorized into 10º increments, allowing construction of a 10-point score. The median AWS score was 5 (interquartile range [IQR], 4-7), and there was agreement within 1 point for 42 of the 45 encounters (93%). The findings from this study demonstrate that the 10-point AWS score may measure AWS in an accurate and reproducible fashion, with potential for objective description of abdominal wall function of VIH patients. This score may help to identify patients suited for abdominal wall reconstruction while measuring progress after VIH repair. Further longitudinal outcomes studies are needed.

  17. Parent-child interactions and objectively measured child physical activity: a cross-sectional study

    Science.gov (United States)

    2010-01-01

    Background Parents influence their children's behaviors directly through specific parenting practices and indirectly through their parenting style. Some practices such as logistical and emotional support have been shown to be positively associated with child physical activity (PA) levels, while for others (e.g. monitoring) the relationship is not clear. The objectives of this study were to determine the relationship between parent's PA-related practices, general parenting style, and children's PA level. Methods During the spring of 2007 a diverse group of 99 parent-child dyads (29% White, 49% Black, 22% Hispanic; 89% mothers) living in low-income rural areas of the US participated in a cross-sectional study. Using validated questionnaires, parents self-reported their parenting style (authoritative, authoritarian, permissive, and uninvolved) and activity-related parenting practices. Height and weight were measured for each dyad and parents reported demographic information. Child PA was measured objectively through accelerometers and expressed as absolute counts and minutes engaged in intensity-specific activity. Results Seventy-six children had valid accelerometer data. Children engaged in 113.4 ± 37.0 min. of moderate-vigorous physical activity (MVPA) per day. Children of permissive parents accumulated more minutes of MVPA than those of uninvolved parents (127.5 vs. 97.1, p parents who provided above average levels of support had children who participated in more minutes of MVPA (114.2 vs. 98.3, p = 0.03). While controlling for known covariates, an uninvolved parenting style was the only parenting behavior associated with child physical activity. Parenting style moderated the association between two parenting practices - reinforcement and monitoring - and child physical activity. Specifically, post-hoc analyses revealed that for the permissive parenting style group, higher levels of parental reinforcement or monitoring were associated with higher levels of child

  18. Parent-child interactions and objectively measured child physical activity: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Hyatt Raymond R

    2010-10-01

    Full Text Available Abstract Background Parents influence their children's behaviors directly through specific parenting practices and indirectly through their parenting style. Some practices such as logistical and emotional support have been shown to be positively associated with child physical activity (PA levels, while for others (e.g. monitoring the relationship is not clear. The objectives of this study were to determine the relationship between parent's PA-related practices, general parenting style, and children's PA level. Methods During the spring of 2007 a diverse group of 99 parent-child dyads (29% White, 49% Black, 22% Hispanic; 89% mothers living in low-income rural areas of the US participated in a cross-sectional study. Using validated questionnaires, parents self-reported their parenting style (authoritative, authoritarian, permissive, and uninvolved and activity-related parenting practices. Height and weight were measured for each dyad and parents reported demographic information. Child PA was measured objectively through accelerometers and expressed as absolute counts and minutes engaged in intensity-specific activity. Results Seventy-six children had valid accelerometer data. Children engaged in 113.4 ± 37.0 min. of moderate-vigorous physical activity (MVPA per day. Children of permissive parents accumulated more minutes of MVPA than those of uninvolved parents (127.5 vs. 97.1, p p = 0.03. While controlling for known covariates, an uninvolved parenting style was the only parenting behavior associated with child physical activity. Parenting style moderated the association between two parenting practices - reinforcement and monitoring - and child physical activity. Specifically, post-hoc analyses revealed that for the permissive parenting style group, higher levels of parental reinforcement or monitoring were associated with higher levels of child physical activity. Conclusions This work extends the current literature by demonstrating the potential

  19. Parent-child interactions and objectively measured child physical activity: a cross-sectional study.

    Science.gov (United States)

    Hennessy, Erin; Hughes, Sheryl O; Goldberg, Jeanne P; Hyatt, Raymond R; Economos, Christina D

    2010-10-07

    Parents influence their children's behaviors directly through specific parenting practices and indirectly through their parenting style. Some practices such as logistical and emotional support have been shown to be positively associated with child physical activity (PA) levels, while for others (e.g. monitoring) the relationship is not clear. The objectives of this study were to determine the relationship between parent's PA-related practices, general parenting style, and children's PA level. During the spring of 2007 a diverse group of 99 parent-child dyads (29% White, 49% Black, 22% Hispanic; 89% mothers) living in low-income rural areas of the US participated in a cross-sectional study. Using validated questionnaires, parents self-reported their parenting style (authoritative, authoritarian, permissive, and uninvolved) and activity-related parenting practices. Height and weight were measured for each dyad and parents reported demographic information. Child PA was measured objectively through accelerometers and expressed as absolute counts and minutes engaged in intensity-specific activity. Seventy-six children had valid accelerometer data. Children engaged in 113.4 ± 37.0 min. of moderate-vigorous physical activity (MVPA) per day. Children of permissive parents accumulated more minutes of MVPA than those of uninvolved parents (127.5 vs. 97.1, p parents who provided above average levels of support had children who participated in more minutes of MVPA (114.2 vs. 98.3, p = 0.03). While controlling for known covariates, an uninvolved parenting style was the only parenting behavior associated with child physical activity. Parenting style moderated the association between two parenting practices - reinforcement and monitoring - and child physical activity. Specifically, post-hoc analyses revealed that for the permissive parenting style group, higher levels of parental reinforcement or monitoring were associated with higher levels of child physical activity. This work

  20. Objectively measured work load, health status and sickness absence among Danish ambulance personnel. A longitudinal study

    DEFF Research Database (Denmark)

    Hansen, Claus D.

    2013-01-01

    Background: Reviews show that ambulance personnel (AP) have an increased risk of work-related health problems especially musculoskeletal disorders. Because of the unpredictable character of the AP’s work environment, standard measures of work environment exposures are imprecise. The aim...... of this presentation is to examine the associations between objectively measured work load taken from the company register, health and long-term sickness absence (LTSA) in 1-year follow up period. Methods: Data is taken from the first round of MARS – Men, accidents, risk and safety, a two wave panel study of AP...... workers in Denmark (n = 1606) collected in winter 2010/11. The response rate to the questionnaire was 62% in the baseline. The respondents were asked about health status, physical (DMQ) and psychosocial work environment factors (COPSOQ). Information from the company register about work load (e.g. mean...

  1. Study of medieval enamelling on gilded objects combining SEM-EDAX and PIXE

    International Nuclear Information System (INIS)

    Chamon, J.; Barrio, J.; Arroyo, M.; Gutierrez, P.C.; Climent-Font, A.

    2010-01-01

    A set of fragments of metallic artefacts from the medieval period excavated from Ciudad Real in Spain has been studied. The objects are gilded copper buckles with a champleve enamelling decoration. The composition of predominantly blue-coloured enamels has been analysed using three non-destructive techniques, SEM-EDAX (scanning electron microscopy coupled with energy-dispersive X-ray analysis), X-ray fluorescence (XRF) and PIXE (particle-induced X-ray emission). Analyses show that Co is responsible for the blue colour. The results of the two techniques are compared, as well as the main components which constitute the enamel. Analyses suggest that Cu is responsible for red colour. (orig.)

  2. Luminosity excesses in low-mass young stellar objects - a statistical study

    International Nuclear Information System (INIS)

    Strom, K.M.; Strom, S.E.; Kenyon, S.J.; Hartmann, L.

    1988-01-01

    This paper presents a statistical study in which the observed total luminosity is compared quantitatively with an estimate of the stellar luminosity for a sample of 59 low-mass young stellar objects (YSOs) in the Taurus-Auriga complex. In 13 of the analyzed YSOs, luminosity excesses greater than 0.20 are observed together with greater than 0.6 IR excesses, which typically contribute the bulk of the observed excess luminosity and are characterized by spectral energy distributions which are flat or rise toward long wavelengths. The analysis suggests that YSOs showing the largest luminosity excesses typically power optical jets and/or molecular outflows or have strong winds, as evidenced by the presence of O I emission, indicating a possible correlation between accretion and mass-outflow properties. 38 references

  3. Gold Provenance Studies for Romanian Archaeological Objects Using Micro-SR-XRF

    Science.gov (United States)

    Vasilescu, Angela; Constantinescu, Bogdan; Bugoi, Roxana; Radtke, Martin; Reinholz, Uwe; Simon, Rolf

    2010-04-01

    Studies by Synchrotron Radiation—X-Ray Fluorescence (SR-XRF) for the search of the presence of trace elements like Sb, Sn, Te and Pb in archaeological metallic objects found on the territory of Romania—old coins and Bronze Age jewelry, aimed to determine the provenance of the gold used in their manufacture. The results are compared with the detailed elemental composition of alluvial or primary gold samples, obtained by the same technique. This work attempted to establish the origin of the gold used for the mint of two different types of koson coins. We found that the kosons with monogram are made of refined gold, while the one used for the kosons without monogram is mainly alluvial. The gold used in the manufacture of the Calarasi Vulchitrun-type disk and the Tauteu hair ring is also of alluvial origin.

  4. [A study on the diagnostic value of tear film objective scatter index in dry eye].

    Science.gov (United States)

    Su, Y D; Liang, Q F; Wang, N L; Antoine, Labbè

    2017-09-11

    Objective: To study the sensitivity and specificity of tear film objective scatter index to the diagnosis dry eye disease (DED). Methods: A prospective case-controlled study. Fifty-three patients with DED and 32 healthy age- and sex-matched control subjects were included from July to October 2016. All subjects underwent the examinations sequentially as follows: evaluation of ocular surface disease symptoms using the Ocular Surface Disease Index, optical quality detection, lipid layer thickness, tear film breakup time and SchirmerⅠtest. With Optical Quality Analysis SystemⅡ, the values of modulation transfer function cut off, basic objective scatter index (OSI) and total OSI were measured. To eliminate the influence of other refractive media, the tear film OSI (TF-OSI) was calculated, and the difference in TF-OSI between two groups was analyzed with the independent-samples t test. Spearman's correlation analysis was used to detect the correlation of each parameter in the DED group. With the receiver operating characteristic curve and the area under the curve (AUC), the specificity and sensitivity of TF-OSI and other parameters were described to differentiate DED from normal eyes. Results: In the dry eye group, the value of modulation transfer function cut off (32.07±11.95) was significantly lower than the normal group (39.38±9.44, t=- 3.096, P= 0.003) , and the mean value and dispersion of TF-OSI (0.50±0.43, 0.52±0.81) were higher than the normal group (0.21±0.16, 0.12±0.01) ( t= 4.300, P= 0.000, t= 3.546, P= 0.001) . The mean value of TF-OSI had a positive correlation with lipid layer thickness ( r= 0.365, P= 0.007) and dispersion of TF-OSI ( r= 0.581, P= 0.000), and a negative correlation with MTF cut off ( r=- 0.368, P= 0.007). To the diagnostic value of DED, the mean value of TF-OSI had a sensitivity of 0.736, a specificity of 0.762, and the AUC was 0.764. The dispersion of TF-OSI had a sensitivity of 0.811 and a specificity of 0.810, and the AUC was 0

  5. Comparison of objective refraction in darkness to cycloplegic refraction: a pilot study.

    Science.gov (United States)

    Vasudevan, Balamurali; Ciuffreda, Kenneth J; Meehan, Kelly; Grk, Dejana; Cox, Misty

    2016-03-01

    The aim was to assess non-cycloplegic objective refraction in darkness using an open-field auto-refractor, and furthermore to compare it with distance cycloplegic subjective refraction and distance cycloplegic retinoscopy in the light, in children and young adults. Twenty-three, visually-normal, young-adults (46 eyes) ages 23 to 31 years, and five children (10 eyes) ages five to 12 years, participated in the study. The spherical component of their refraction ranged from -2.25 D to +3.75 D with a mean of +1.80 D, and a mean cylinder of -0.70 D. Three techniques were used to assess refractive error. An objective measure of the non-cycloplegic refractive state was obtained using an open-field autorefractor (WAM-5500) after five minutes in the dark to allow for dissipation of accommodative transients and relaxation of accommodation. In addition, both distance retinoscopy and subjective distance refraction were performed following cycloplegia (Cyclopentolate, 1%) using conventional clinical procedures. All measurements were obtained on the same day within a single session. The spherical component of the refraction was compared among the three techniques in both the children and adults. There was no significant difference in spherical refraction among the three techniques: non-cycloplegic objective refraction in the dark, distance cycloplegic retinoscopy and distance cycloplegic subjective refraction, in either the adults [F(2, 137) = 0.79, p = 0.45] or the children [F(2, 27) = 0.47, p = 0.62]. Mean difference in the spherical component between refraction in the dark and the cycloplegic distance retinoscopy was -0.34 D (r = 0.89) in the adults and +0.14 D (r = 0.96) in the children. The mean difference in spherical component between refraction in the dark and the cycloplegic distance subjective refraction was -0.25 D (r = 0.92) in the adults and -0.05 D (r = 0.95) in the children. Comparison of the spherical refractive component between the three techniques was not

  6. The possibility of previous epidemiological data to serve as baseline for future national oral health surveys--a study in Vietnam.

    NARCIS (Netherlands)

    Palenstein Helderman, W.H. van; Truin, G.J.; Can, N.; Khanh, N.D.

    2001-01-01

    AIM: The purpose of this paper is to review the most recent epidemiological data (1985-2000) on dental caries and periodontal diseases in Vietnam in an attempt to obtain a 'baseline' for future national oral health surveys. METHODS: Studies on periodontal diseases and caries were included when CPITN

  7. Study of archaeological iron objects by PGAA, Mössbauer spectroscopy and X-ray diffraction

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, F. E., E-mail: fwagner@tum.de [Technische Universität München, Physik- Department E15 (Germany); Gebhard, R. [Archäologische Staatssammlung München (Germany); Häusler, W.; Wagner, U. [Technische Universität München, Physik- Department E15 (Germany); Albert, P.; Hess, H. [Archäologische Staatssammlung München (Germany); Révay, Z.; Kudejová, P.; Kleszcz, K. [Technische Universität München, Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM II) (Germany)

    2016-12-15

    Archaeological iron objects often corrode rapidly after their excavation, even though they have survived long times of burial in the ground. Chlorine that accumulates during burial is thought to play a major role in this destructive post-excavation corrosion. It is therefore important for the conservation of such objects to determine the chlorine content in a non-destructive manner and, if necessary, to remove the chlorine from the artefacts by appropriate methods. Such methods are leaching in alkaline solutions or heating in a reducing atmosphere at temperatures up to 800 {sup ∘}C. We have studied the efficiency of the heating method using prompt gamma activation analysis (PGAA) for monitoring the Cl content and Mössbauer spectroscopy at room temperature (RT) and 4.2 K as well as X-ray diffraction to study the mineralogical transformations of the rust layers. The heat treatments were performed a N{sub 2}/H{sub 2} (90/10) mixture at temperatures up to 750 {sup ∘}C. As test specimens sections of iron rods from the Celtic oppidum of Manching (Bavaria) were used. The initial Cl contents of the pieces varied in the range of several hundred ppm, referring to the iron mass. Annealing for 24 h at 350, 550 and 750 {sup ∘}C was found to reduce the Cl contents of the specimens, to about 70, 30 and 15 % of the original values, respectively. The rust consists mainly of goethite with admixtures of magnetite, lepidocrocite and akaganeite, which is thought to be a major carrier of chlorine, probably together with iron chlorides. Much of the goethite is so fine-grained that it does not split magnetically at RT. Annealing converts the rust mainly to maghemite at 350 {sup ∘}C, to magnetite at 550 {sup ∘}C and to wüstite plus magnetite and metallic iron at 750 {sup ∘}C. Pure akaganeite behaves in nearly the same manner.

  8. Study of archaeological iron objects by PGAA, Mössbauer spectroscopy and X-ray diffraction

    International Nuclear Information System (INIS)

    Wagner, F. E.; Gebhard, R.; Häusler, W.; Wagner, U.; Albert, P.; Hess, H.; Révay, Z.; Kudejová, P.; Kleszcz, K.

    2016-01-01

    Archaeological iron objects often corrode rapidly after their excavation, even though they have survived long times of burial in the ground. Chlorine that accumulates during burial is thought to play a major role in this destructive post-excavation corrosion. It is therefore important for the conservation of such objects to determine the chlorine content in a non-destructive manner and, if necessary, to remove the chlorine from the artefacts by appropriate methods. Such methods are leaching in alkaline solutions or heating in a reducing atmosphere at temperatures up to 800 "∘C. We have studied the efficiency of the heating method using prompt gamma activation analysis (PGAA) for monitoring the Cl content and Mössbauer spectroscopy at room temperature (RT) and 4.2 K as well as X-ray diffraction to study the mineralogical transformations of the rust layers. The heat treatments were performed a N_2/H_2 (90/10) mixture at temperatures up to 750 "∘C. As test specimens sections of iron rods from the Celtic oppidum of Manching (Bavaria) were used. The initial Cl contents of the pieces varied in the range of several hundred ppm, referring to the iron mass. Annealing for 24 h at 350, 550 and 750 "∘C was found to reduce the Cl contents of the specimens, to about 70, 30 and 15 % of the original values, respectively. The rust consists mainly of goethite with admixtures of magnetite, lepidocrocite and akaganeite, which is thought to be a major carrier of chlorine, probably together with iron chlorides. Much of the goethite is so fine-grained that it does not split magnetically at RT. Annealing converts the rust mainly to maghemite at 350 "∘C, to magnetite at 550 "∘C and to wüstite plus magnetite and metallic iron at 750 "∘C. Pure akaganeite behaves in nearly the same manner.

  9. Encoding of faces and objects into visual working memory: an event-related brain potential study.

    Science.gov (United States)

    Meinhardt-Injac, Bozana; Persike, Malte; Berti, Stefan

    2013-09-11

    Visual working memory (VWM) is an important prerequisite for cognitive functions, but little is known on whether the general perceptual processing advantage for faces also applies to VWM processes. The aim of the present study was (a) to test whether there is a general advantage for face stimuli in VWM and (b) to unravel whether this advantage is related to early sensory processing stages. To address these questions, we compared encoding of faces and complex nonfacial objects into VWM within a combined behavioral and event-related brain potential (ERP) study. In detail, we tested whether the N170 ERP component - which is associated with face-specific holistic processing - is affected by memory load for faces or whether it might be involved in WM encoding of any complex object. Participants performed a same-different task with either face or watch stimuli and with two different levels of memory load. Behavioral measures show an advantage for faces on the level of VWM, mirrored in higher estimated VWM capacity (i.e. Cowan's K) for faces compared with watches. In the ERP, the N170 amplitude was enhanced for faces compared with watches. However, the N170 was not modulated by working memory load either for faces or for watches. In contrast, the P3b component was affected by memory load irrespective of the stimulus category. Taken together, the results suggest that the VWM advantage for faces is not reflected at the sensory stages of stimulus processing, but rather at later higher-level processes as reflected by the P3b component.

  10. Study of archaeological iron objects by PGAA, Mössbauer spectroscopy and X-ray diffraction

    Science.gov (United States)

    Wagner, F. E.; Gebhard, R.; Häusler, W.; Wagner, U.; Albert, P.; Hess, H.; Révay, Z.; Kudejová, P.; Kleszcz, K.

    2016-12-01

    Archaeological iron objects often corrode rapidly after their excavation, even though they have survived long times of burial in the ground. Chlorine that accumulates during burial is thought to play a major role in this destructive post-excavation corrosion. It is therefore important for the conservation of such objects to determine the chlorine content in a non-destructive manner and, if necessary, to remove the chlorine from the artefacts by appropriate methods. Such methods are leaching in alkaline solutions or heating in a reducing atmosphere at temperatures up to 800 ∘C. We have studied the efficiency of the heating method using prompt gamma activation analysis (PGAA) for monitoring the Cl content and Mössbauer spectroscopy at room temperature (RT) and 4.2 K as well as X-ray diffraction to study the mineralogical transformations of the rust layers. The heat treatments were performed a N2/H2 (90/10) mixture at temperatures up to 750 ∘C. As test specimens sections of iron rods from the Celtic oppidum of Manching (Bavaria) were used. The initial Cl contents of the pieces varied in the range of several hundred ppm, referring to the iron mass. Annealing for 24 h at 350, 550 and 750 ∘C was found to reduce the Cl contents of the specimens, to about 70, 30 and 15 % of the original values, respectively. The rust consists mainly of goethite with admixtures of magnetite, lepidocrocite and akaganeite, which is thought to be a major carrier of chlorine, probably together with iron chlorides. Much of the goethite is so fine-grained that it does not split magnetically at RT. Annealing converts the rust mainly to maghemite at 350 ∘C, to magnetite at 550 ∘C and to wüstite plus magnetite and metallic iron at 750 ∘C. Pure akaganeite behaves in nearly the same manner.

  11. Alfalfa (Medicago sativa L.) is tolerant to higher levels of salinity than previous guidelines indicated: Implications of field and greenhouse studies

    Science.gov (United States)

    Putnam, Daniel H.; Benes, Sharon; Galdi, Giuliano; Hutmacher, Bob; Grattan, Steve

    2017-04-01

    Alfalfa (Medicago sativa L.) is the most widely grown leguminous forage crop in North America and is valued for high productivity, quality, economic value, and for dairy productivity. Alfalfa has historically been classified as moderately sensitive to saline conditions, with yield declines predicted at >2 dS/m in the saturated soil paste extract. However, greenhouse, sand tank, and field studies over the past five years have confirmed that alfalfa can be grown with limited negative effects at much higher salinity levels. A broad collection of alfalfa varieties has exhibited a range of resistance at irrigation water salinities >5 dS/m ECw in greenhouse trials, with significant variation due to variety. USDA-ARS sand tank studies indicated similar or greater tolerances closer to 8 dS/m in the soil water, in addition to confirmation of significant varietal differences. A three-year field study on clay loam soil with applications of 5-7 dS/m ECw irrigation water indicated normal yields and excellent stand survivability. A second field study in the same soil type with levels from 8-10 dS/m ECw showed yield reductions of 10-15% but economic yields were still achieved at those levels. Field and greenhouse studies were conducted with mixed salt saline sodic waters typical of the San Joaquin Valley of California. Field evaluation of variety performance was subject to greater variation due to secondary salinity-soil interactions including water infiltration and crusting problems, not only salinity per-se. Thus, adequate irrigation water availability to the crop may be as important as salinity in impacting yields under field conditions. Once established, the deep-rooted characteristics of alfalfa enable utilization of deeper subsurface moisture, even at moderate to high salinity levels, as documented by USDA lysimeter studies. Significant advantages to salinity-tolerant varieties have been observed. It will be important to consider specific management factors which may enable

  12. Effect of benzalkonium chloride?free travoprost on intraocular pressure and ocular surface symptoms in patients with glaucoma previously on latanoprost: an open-label study

    OpenAIRE

    Lopes, Joao F.; Hubatsch, Douglas A.; Amaris, Patricia

    2015-01-01

    Background Prostaglandin analogs reduce intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension; however, these medications may affect the ocular surface and elicit ocular discomfort when preserved with benzalkonium chloride (BAK). Methods This was an open-label, single-arm study conducted in Latin America from February 2012 to May 2013. Patients with open-angle glaucoma or ocular hypertension who were intolerant of latanoprost 0.005?% were transitioned to recei...

  13. Unrewarded Object Combinations in Captive Parrots

    Directory of Open Access Journals (Sweden)

    Alice Marie Isabel Auersperg

    2014-11-01

    Full Text Available In primates, complex object combinations during play are often regarded as precursors of functional behavior. Here we investigate combinatory behaviors during unrewarded object manipulation in seven parrot species, including kea, African grey parrots and Goffin cockatoos, three species previously used as model species for technical problem solving. We further examine a habitually tool using species, the black palm cockatoo. Moreover, we incorporate three neotropical species, the yellow- and the black-billed Amazon and the burrowing parakeet. Paralleling previous studies on primates and corvids, free object-object combinations and complex object-substrate combinations such as inserting objects into tubes/holes or stacking rings onto poles prevailed in the species previously linked to advanced physical cognition and tool use. In addition, free object-object combinations were intrinsically structured in Goffin cockatoos and in kea.

  14. Effect of benzalkonium chloride-free travoprost on intraocular pressure and ocular surface symptoms in patients with glaucoma previously on latanoprost: an open-label study.

    Science.gov (United States)

    Lopes, Joao F; Hubatsch, Douglas A; Amaris, Patricia

    2015-11-12

    Prostaglandin analogs reduce intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension; however, these medications may affect the ocular surface and elicit ocular discomfort when preserved with benzalkonium chloride (BAK). This was an open-label, single-arm study conducted in Latin America from February 2012 to May 2013. Patients with open-angle glaucoma or ocular hypertension who were intolerant of latanoprost 0.005 % were transitioned to receive once-daily BAK-free travoprost 0.004 % containing polyquaternium-1 (Travatan® preserved with POLYQUAD® [PQ], Alcon Laboratories, Inc; Fort Worth, TX) for 12 weeks. Mean change in IOP from baseline (primary efficacy endpoint) and the percentage of patients who achieved a target IOP of ≤18 mmHg were evaluated at all on-therapy visits. Ocular hyperemia, patient preference, and self-projected adherence were assessed at week 12. Adverse events (AEs) were monitored throughout the study. All enrolled patients were included in the analysis (n = 191); the majority of patients (90.6 %, n = 173/191) completed the study. Mean (SD) patient age was 67.5 (11.3) years, and mean baseline IOP was 14.8 mmHg. Mean IOP was reduced by 0.94 mmHg at week 6 and by 1.09 mmHg at week 12 (P glaucoma or ocular hypertension who were intolerant of latanoprost. BAK-free travoprost 0.004 % is a viable alternative for patients who require switching their IOP-lowering medications because of tolerability issues. ClinicalTrials.gov identifier, NCT01510145.

  15. Does hyperbaric oxygen treatment have the potential to increase salivary flow rate and reduce xerostomia in previously irradiated head and neck cancer patients? A pilot study

    DEFF Research Database (Denmark)

    Forner, Lone; Hansen, Ole Hyldegaard; von Brockdorff, Annet Schack

    2011-01-01

    in irradiated head and neck cancer patients. Eighty patients eligible for HBO treatment on the indication of prevention/treatment of osteoradionecrosis or soft tissue radiation injury were consecutively sampled, of whom 45 had hyposalivation (i.e. unstimulated whole saliva (UWS) flow rate......Irradiated head and neck cancer survivors treated in the Hyperbaric Oxygen (HBO) Unit, Copenhagen University Hospital, spontaneously reported improvement of radiation-induced dry mouth feeling. The aim of this pilot study was to evaluate salivary flow rate and xerostomia before and after HBO...

  16. Previous study for the setting up and optimization of detection of ZnS(Ag) scintillation applied to the measure of alpha radioactivity index

    International Nuclear Information System (INIS)

    Pujol, L.; Suarez-Navarro, J.A.; Montero, M.

    1998-01-01

    The determination of radiological water quality is useful for a wide range of environmental studies. In these cases, the gross alpha activity is one of the parameters to determine. This parameter permits to decide if further radiological analyses are necessary in order to identify and quantify the presence of alpha emitters in water. The usual method for monitoring the gross alpha activity includes sample evaporation to dryness on a disk and counting using ZnS(Ag) scintillation detector. Detector electronics is provided with two components which are adjustable by the user the high-voltage applied to the photomultiplier tubes and the low level discriminator that is used to eliminate the electronic noise. The high-voltage and low level discriminator optimization are convenient in order to reach the best counting conditions. This paper is a preliminary study of the procedure followed for the setting up and optimization of the detector electronics in the laboratories of CEDEX for the measurement of gross alpha activity. (Author)

  17. [Mutations of resistance of HIV-1 in previously untreated patients at penitentiary centers of the Autonomous Community of Valencia, Spain. REPRICOVA study].

    Science.gov (United States)

    García-Guerrero, Julio; Herrero, Agustín; Vera, Enrique; Almenara, José M; Araújo, Rosa; Saurí, Vicente V; Castellano, Juan C; Fernández-Clemente, Luis; Bedia, Miguel; Llorente, María I; González-Morán, Francisco

    2002-03-02

    Our purpose was to determine the prevalence of mutations of resistance to nucleoside inhibitors of reverse transcriptase (NIRT) and protease inhibitors (PI) in the HIV-1 genotype of naïve infected subjects in the prisons of the Autonomous Community of Valencia, Spain. Multicentric, descriptive, cross-sectional study of prevalence including a systematic stratified and randomised sampling by centres. Demographic, clinical, virological and immunological data were collected. The HIV gene of protease and transcriptase was studied in peripheral blood plasma samples by means of double PCR amplification and subsequent automatic sequence. Reference: wild strain HXB2. Plasma was obtained from 133 individuals (119 men and 14 women). 117 samples were selected and the rest did not have enough copies for transcription. With regard to NIRT, 7 samples (5.2% of total) showed some mutation of resistance: M41L, D67N, L210W and K219Q, all them secondary to and associated with resistance to zidovudine, abacavir as well as group B multinucleoside-resistance. With regard to PI, only one sample showed a primary mutation, M46I, which was associated with resistance to indinavir. Moreover, a further 41 samples were found to express some secondary mutation. In our series, there was a low number of primary mutations of resistance. These results allow us to exclude the systematic use of resistance tests before an initiation antiretroviral therapy.

  18. Processing subject-object ambiguities in Dutch

    NARCIS (Netherlands)

    Kaan, Edith

    1997-01-01

    Various clause types in Dutch and German are at least temporarily ambiguous with respect to the order of subject and object. A number of previous studies regarding the processing of such subject-object ambiguities have reported a preference for a subject-object interpretation. This order preference

  19. Study design, objectives, hypotheses, main findings, health consequences for the population exposed, rationale of future research

    Energy Technology Data Exchange (ETDEWEB)

    Trnovec, T.; Kocan, A. [Slovak Medical Univ., Bratislava (Slovakia); Bencko, V. [Charles Univ., Prague (Czech Republic); Langer, P. [Institute of Experimental Endocrinology SAS, Bratislava (Slovakia); Berg, M. van den [Rijksuniversiteit Utrecht (Netherlands); Bergman, A. [Stockholm Univ. (Sweden); Hustak, M. [Air Force Military Hospital, Kosics (Slovakia)

    2004-09-15

    In Slovakia, the Chemko Chemical Company, based in Strazske, in the Michalovce district, produced PCBs between 1959 and 1984, in the amount of more than 21,000 tons of commercial mixtures (Delor 103, 104, 105, 106, Delotherm DK and DH, Hydelor 137). PCBs were used for similar industrial purposes as in the west. Improper disposal from the Chemko plant via release of effluent directly into the Laborec River resulted in long-term contamination of sediment. As a result eastern Slovakia, the Michalovce district in particular, is recognized as one of the areas all over the world most heavily polluted with PCBs. Historical studies show that blood and adipose PCB levels were higher in Czechoslovakia than elsewhere in the 1970's and 1980's. Current data indicate that persons who eat locally raised food - pork, beef, poultry, eggs - in this district have elevated serum concentrations of PCBs. Environmental exposure to organochlorines in the Michalovce district indicate association with higher rates of certain cancers, but an inverse association with risk of breast cancer. An increased prevalence of thyroid disorders in the polluted area was also reported. This ''experimental setting in nature'' has attracted international scientific teams and two projects in the area are ongoing: Evaluating Human Health Risk from Low-dose and Long-term PCB Exposure, 5{sup th} FP Project QLK4-2000-00488, 2001- 2004; PCBRISK (http://www.pcbrisk.sk/) and Early Childhood Development and PCB Exposures in Slovakia, NCI/NIH, R01-CA96525 University of California, Davis, USA. This paper is serving as an introduction to papers of a session reporting on various health outcomes associated with PCB exposure. The objectives of the PCBRISK project were targeted at an evaluation of the human health risks of low-dose and long-term exposure to a group of persistent organochlorine pollutants, including polychlorinated biphenyls (PCBs) and their metabolites, organochlorine

  20. Selection of Objective Function For Imbalanced Classification: An Industrial Case Study

    DEFF Research Database (Denmark)

    Khan, Abdul Rauf; Schiøler, Henrik; Kulahci, Murat

    2017-01-01

    In this article we discuss the issue of selecting suitable objective function for Genetic Algorithm to solve an imbalanced classification problem. More precisely, first we discuss the need of specialized objective function to solve a real classification problem from our industrial partner and the...... and then we compare the results of our proposed objective function with commonly used candidates to serve this purpose. Our comparison is based on the analysis of real data collected during the quality control stages of the manufacturing process....

  1. Dose profile study on computerized tomography scanning of skull with simulator object

    International Nuclear Information System (INIS)

    Mourao, A.P.

    2011-01-01

    This work presents a comparison among the dose profiles in scanning of computerized tomography of a simulator object of PMMA in its periphery region. To obtain the deposited dose at the PMMA thermoluminescent dosemeters were used positioned at the interior of PMMA simulated object longitudinal to periphery and at the center of cylinder (positions denominated North, South, East, West and Center). Eight scanning were performed of simulator object using the routine protocol for skull in eight different services of radiodiagnostic by TC

  2. In Vitro Fertilization Outcomes After Placement of Essure Microinserts in Patients With Hydrosalpinges Who Previously Failed In Vitro Fertilization Treatment: A Multicenter Study.

    Science.gov (United States)

    Cohen, Shlomo B; Bouaziz, Jerome; Schiff, Eyal; Simon, Alexander; Nadjary, Michel; Goldenberg, Mordechai; Orvieto, Raoul; Revel, Ariel

    2016-01-01

    To investigate whether hysteroscopic proximal tubal occlusion with Essure microinserts (Conceptus Inc.; Bayer, AG, North Rhine-Westphalia, Germany) can improve pregnancy rates in patients with hydrosalpinges who had failed in vitro fertilization (IVF) treatment. A prospective cohort study. University-affiliated tertiary centers. Twenty-four consecutive women with hydrosalpinges who had failed IVF treatment were included. Hysteroscopic placement of Essure microinserts for hydrosalpinx blockage followed by IVF treatment. Ongoing pregnancy and live birth rates were recorded. Of the 24 patients undergoing a total of 42 IVF cycles after Essure insertion, 18 (75% of patients and 42.8% of IVF cycle attempts) conceived and 16 delivered live births (66.6% of patients and 38.1% of IVF cycle attempts). Hysteroscopic proximal occlusion of hydrosalpinges with Essure microinserts is a valuable alternative to laparoscopic salpingectomy, resulting in reasonable pregnancy rates. Copyright © 2016 AAGL. Published by Elsevier Inc. All rights reserved.

  3. Testing the Formation Mechanism of Sub-Stellar Objects in Lupus (A SOLA Team Study)

    Science.gov (United States)

    De Gregorio-Monsalvo, Itziar; Lopez, C.; Takahashi, S.; Santamaria-Miranda

    2017-06-01

    The international SOLA team (Soul of Lupus with ALMA) has identified a set of pre- and proto-stellar candidates in Lupus 1 and 3 of substellar nature using 1.1mm ASTE/AzTEC maps and our optical to submillimeter database. We have observed with ALMA the most promising pre- and proto-brown dwarfs candidates. Our aims are to provide insights on how substellar objects form and evolve, from the equivalent to the pre-stellar cores to the Class II stage in the low mass regime of star formation. Our sample comprises 33 pre-stellar objects, 7 Class 0 and I objects, and 22 Class II objects.

  4. Kansas City Cardiomyopathy Questionnaire Score Is Associated With Incident Heart Failure Hospitalization in Patients With Chronic Kidney Disease Without Previously Diagnosed Heart Failure: Chronic Renal Insufficiency Cohort Study.

    Science.gov (United States)

    Mishra, Rakesh K; Yang, Wei; Roy, Jason; Anderson, Amanda H; Bansal, Nisha; Chen, Jing; DeFilippi, Christopher; Delafontaine, Patrice; Feldman, Harold I; Kallem, Radhakrishna; Kusek, John W; Lora, Claudia M; Rosas, Sylvia E; Go, Alan S; Shlipak, Michael G

    2015-07-01

    Chronic kidney disease is a risk factor for heart failure (HF). Patients with chronic kidney disease without diagnosed HF have an increased burden of symptoms characteristic of HF. It is not known whether these symptoms are associated with occurrence of new onset HF. We studied the association of a modified Kansas City Cardiomyopathy Questionnaire with newly identified cases of hospitalized HF among 3093 participants enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study who did not report HF at baseline. The annually updated Kansas City Cardiomyopathy Questionnaire score was categorized into quartiles (Q1-4) with the lower scores representing the worse symptoms. Multivariable-adjusted repeated measure logistic regression models were adjusted for demographic characteristics, clinical risk factors for HF, N-terminal probrain natriuretic peptide level and left ventricular hypertrophy, left ventricular systolic and diastolic dysfunction. Over a mean (±SD) follow-up period of 4.3±1.6 years, there were 211 new cases of HF hospitalizations. The risk of HF hospitalization increased with increasing symptom quartiles; 2.62, 1.85, 1.14, and 0.74 events per 100 person-years, respectively. The median number of annual Kansas City Cardiomyopathy Questionnaire assessments per participant was 5 (interquartile range, 3-6). The annually updated Kansas City Cardiomyopathy Questionnaire score was independently associated with higher risk of incident HF hospitalization in multivariable-adjusted models (odds ratio, 3.30 [1.66-6.52]; P=0.001 for Q1 compared with Q4). Symptoms characteristic of HF are common in patients with chronic kidney disease and are associated with higher short-term risk for new hospitalization for HF, independent of level of kidney function, and other known HF risk factors. © 2015 American Heart Association, Inc.

  5. Ultrasonography as a prognostic and objective parameter in Achilles tendinopathy: A prospective observational study

    International Nuclear Information System (INIS)

    Bakkegaard, Mads; Johannsen, Finn E.; Højgaard, Betina; Langberg, Henning

    2015-01-01

    Objectives: To study prospectively whether structural changes determined by ultrasound scanning (US) can be used as prognostic markers for outcome in patients with symptomatic Achilles tendinopathy (AT) and to investigate whether there exists an association between US findings and pain measured by visual analog scale (VAS) and a general assessment score (GA). Methods: 92 consecutive patients with AT symptoms were recruited from two outpatient clinics in rheumatology. The patients underwent a conservative treatment protocol consisting of reduced activities, controlled rehabilitation including eccentric exercises of the calf muscles and if needed supplemented with corticosteroid injections. The patients were examined clinically and by US (tendon thickness, hyper- and hypoechogenicity, calcification, bursitis, calcaneusspure, tenosynovitis, gray scale and color Doppler focusing on increased flow intra- or peritendinous). The clinical and US examination were performed at entry, 1, 2, 3 and at 6 month. Results: 42 women and 50 men were included (mean age of 47 years). They had symptoms for more than 13 months and a symptomatic Achilles tendon mean thickness of 7.4 ± 2.3 mm. Heterogeneity at the initial examination was found to be a prognostic marker for the clinical outcome. Tendon thickness, hypoechogenicity and increased flow at any time point were significantly correlated to pain at function, palpatory pain and morning pain at the same time points. A reduction in tendon thickness was statistically associated with a decrease in palpatory pain. Conclusion: Heterogeneity is a prognostic marker in AT. Tendon thickness, hypoechogenicity and increased Doppler activity can be used as objective outcome parameters for the treatment effect of AT

  6. Recent developments in atomic/nuclear methodologies used for the study of cultural heritage objects

    International Nuclear Information System (INIS)

    Appoloni, Carlos Roberto

    2013-01-01

    Archaeometry is an area established in the international community since the 60s, with extensive use of atomic-nuclear methods in the characterization of art, archaeological and cultural heritage objects in general. In Brazil, however, until the early '90s, employing methods of physics, only the area of archaeological dating was implemented. It was only after this period that Brazilian groups became involved in the characterization of archaeological and art objects with these methodologies. The Laboratory of Applied Nuclear Physics, State University of Londrina (LFNA/UEL) introduced, pioneered in 1994, Archaeometry and related issues among its priority lines of research, after a member of LFNA has been involved in 1992 with the possibilities of tomography in archaeometry, as well as the analysis of ancient bronzes by EDXRF. Since then, LFNA has been working with PXRF and Portable Raman in several museums in Brazil, in field studies of cave paintings and in the laboratory with material sent by archaeologists, as well as carrying out collaborative work with new groups that followed in this area. From 2003/2004 LAMFI/DFN/IFUSP and LIN/COPPE/UFRJ began to engage in the area, respectively with methodologies using ion beams and PXRF, then over time incorporating other techniques, followed later by other groups. Due to the growing number of laboratories and institutions/archaeologists/conservators interested in these applications, in may 2012 was created a network of available laboratories, based at http://www.dfn.if.usp.br/lapac. It will be presented a panel of recent developments and applications of these methodologies by national groups, as well as a sampling of what has been done by leading groups abroad.

  7. Objectively measured physical activity in Finnish employees: a cross-sectional study.

    Science.gov (United States)

    Mutikainen, Sara; Helander, Elina; Pietilä, Julia; Korhonen, Ilkka; Kujala, Urho M

    2014-12-10

    To objectively measure the amount of intensity-specific physical activity by gender and age with respect to body mass index (BMI) during workdays and days off among Finnish employees. A cross-sectional study. Primary care occupational healthcare units. A sample of 9554 Finnish employees (4221 men and 5333 women; age range 18-65 years; BMI range 18.5-40 kg/m(2)) who participated in health assessments related to occupational health promotion. The amount of moderate-to-vigorous (MVPA) and vigorous (VPA) physical activity (≥3 and ≥6 metabolic equivalents, respectively) was assessed by estimating the minute-to-minute oxygen consumption from the recorded beat-to-beat R-R interval data. The estimation method used heart rate, respiration rate and on/off response information from R-R interval data calibrated by age, gender, height, weight and self-reported physical activity class. The proportion of participants fulfilling the aerobic physical activity recommendation of ≥150 min/week was calculated on the basis of ≥10 min bouts, by multiplying the VPA minutes by 2. Both MVPA and VPA were higher among men and during days off, and decreased with increasing age and BMI (pphysical activity recommendation was highest for normal weight men (65%; 95% CI 62% to 67%) and lowest for obese women (10%; 95% CI 8% to 12%). Objectively measured physical activity is higher among men and during days off, and decreases with increasing age and BMI. The amount of VPA is very low among obese, overweight and older women. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  8. Objective Assessment of Activity Limitation in Glaucoma with Smartphone Virtual Reality Goggles: A Pilot Study.

    Science.gov (United States)

    Goh, Rachel L Z; Kong, Yu Xiang George; McAlinden, Colm; Liu, John; Crowston, Jonathan G; Skalicky, Simon E

    2018-01-01

    To evaluate the use of smartphone-based virtual reality to objectively assess activity limitation in glaucoma. Cross-sectional study of 93 patients (54 mild, 22 moderate, 17 severe glaucoma). Sociodemographics, visual parameters, Glaucoma Activity Limitation-9 and Visual Function Questionnaire - Utility Index (VFQ-UI) were collected. Mean age was 67.4 ± 13.2 years; 52.7% were male; 65.6% were driving. A smartphone placed inside virtual reality goggles was used to administer the Virtual Reality Glaucoma Visual Function Test (VR-GVFT) to participants, consisting of three parts: stationary, moving ball, driving. Rasch analysis and classical validity tests were conducted to assess performance of VR-GVFT. Twenty-four of 28 stationary test items showed acceptable fit to the Rasch model (person separation 3.02, targeting 0). Eleven of 12 moving ball test items showed acceptable fit (person separation 3.05, targeting 0). No driving test items showed acceptable fit. Stationary test person scores showed good criterion validity, differentiating between glaucoma severity groups ( P = 0.014); modest convergence validity, with mild to moderate correlation with VFQ-UI, better eye (BE) mean deviation, BE pattern deviation, BE central scotoma, worse eye (WE) visual acuity, and contrast sensitivity (CS) in both eyes ( R = 0.243-0.381); and suboptimal divergent validity. Multivariate analysis showed that lower WE CS ( P = 0.044) and greater age ( P = 0.009) were associated with worse stationary test person scores. Smartphone-based virtual reality may be a portable objective simulation test of activity limitation related to glaucomatous visual loss. The use of simulated virtual environments could help better understand the activity limitations that affect patients with glaucoma.

  9. Spatial processes decouple management from objectives in a heterogeneous landscape: predator control as a case study.

    Science.gov (United States)

    Mahoney, Peter J; Young, Julie K; Hersey, Kent R; Larsen, Randy T; McMillan, Brock R; Stoner, David C

    2018-04-01

    Predator control is often implemented with the intent of disrupting top-down regulation in sensitive prey populations. However, ambiguity surrounding the efficacy of predator management, as well as the strength of top-down effects of predators in general, is often exacerbated by the spatially implicit analytical approaches used in assessing data with explicit spatial structure. Here, we highlight the importance of considering spatial context in the case of a predator control study in south-central Utah. We assessed the spatial match between aerial removal risk in coyotes (Canis latrans) and mule deer (Odocoileus hemionus) resource selection during parturition using a spatially explicit, multi-level Bayesian model. With our model, we were able to evaluate spatial congruence between management action (i.e., coyote removal) and objective (i.e., parturient deer site selection) at two distinct scales: the level of the management unit and the individual coyote removal. In the case of the former, our results indicated substantial spatial heterogeneity in expected congruence between removal risk and parturient deer site selection across large areas, and is a reflection of logistical constraints acting on the management strategy and differences in space use between the two species. At the level of the individual removal, we demonstrated that the potential management benefits of a removed coyote were highly variable across all individuals removed and in many cases, spatially distinct from parturient deer resource selection. Our methods and results provide a means of evaluating where we might anticipate an impact of predator control, while emphasizing the need to weight individual removals based on spatial proximity to management objectives in any assessment of large-scale predator control. Although we highlight the importance of spatial context in assessments of predator control strategy, we believe our methods are readily generalizable in any management or large

  10. The "Profiles" document: a modern revision of the objectives of undergraduate medical studies in Switzerland.

    Science.gov (United States)

    Michaud, Pierre-André; Jucker-Kupper, Patrick; The Profiles Working Group

    2016-01-01

    The Joint Commission of the Swiss Medical Schools (SMIFK/CIMS) decided in 2000 to establish a Swiss Catalogue of Learning Objectives (SCLO) for undergraduate medical training, which was adapted from a similar Dutch blueprint. A second version of the SCLO was developed and launched in 2008. The catalogue is a prerequisite for the accreditation of the curricula of the six Swiss medical faculties and defines the contents of the Federal Licensing Examination (FLE). Given the evolution of the field of medicine and of medical education, the SMIFK/CIMS has decided to embark on a total revision of the SCLO. This article presents the proposed structure and content of Profiles, a new document which, in the future, will direct the format of undergraduate studies and of the FLE. Profiles stands for the Principal Relevant Objectives for Integrative Learning and Education in Switzerland. It is currently being developed by a group of experts from the six Swiss faculties as well as representatives of other institutions involved in these developments. The foundations of Profiles are grounded in the evolution of medical practice and of public health and are based on up-to-date teaching concepts, such as EPAs (entrustable professional activities). An introduction will cover the concepts and a tutorial will be displayed. Three main chapters will provide a description of the seven 2015 CanMEDS roles, a list of core EPAs and a series of ≈250 situations embracing the most frequent and current conditions affecting health. As Profiles is still a work in progress, it is hoped that this paper will attract the interest of all individuals involved in the training of medical students.

  11. Recent developments in atomic/nuclear methodologies used for the study of cultural heritage objects

    International Nuclear Information System (INIS)

    Appoloni, Carlos Roberto

    2012-01-01

    Full text: Archaeometry is an area established in the international community since the 60s, with extensive use of atomic- nuclear methods in the characterization of art, archaeological and cultural heritage objects in general. In Brazil, however, until the early '90s, employing methods of physics, only the area of archaeological dating was implemented. It was only after this period that Brazilian groups became involved in the characterization of archaeological and art objects with these methodologies. The Laboratory of Applied Nuclear Physics, State University of Londrina (LFNA/UEL) introduced, pioneered in 1994, Archaeometry and related issues among its priority lines of research, after a member of LFNA has been involved in 1992 with the possibilities of tomography in archaeometry, as well as the analysis of ancient bronzes by EDXRF. Since then, LFNA has been working with PXRF and Portable Raman in several museums in Brazil, in field studies of cave paintings and in the laboratory with material sent by archaeologists, as well as carrying out collaborative work with new groups that followed in this area. From 2003/2004 LAMFI/DFN/IFUSP and LIN/COPPE/UFRJ began to engage in the area, respectively with methodologies using ion beams and PXRF, then over time incorporating other techniques, followed later by other groups. Due to the growing number of laboratories and institutions / archaeologists / conservators interested in these applications, in may 2012 was created a network of available laboratories, based at http://www.dfn.if.usp.br/lapac. It will be presented a panel of recent developments and applications of these methodologies by national groups, as well as a sampling of what has been done by leading groups abroad. (author)

  12. Ultrasonography as a prognostic and objective parameter in Achilles tendinopathy: A prospective observational study

    Energy Technology Data Exchange (ETDEWEB)

    Bakkegaard, Mads, E-mail: mbakkegaard@hotmail.com [Department of Rheumatology, Holbæk Hospital, Smedelundsgade 60, 4300 Holbæk (Denmark); Johannsen, Finn E., E-mail: f.e.johannsen@dadlnet.dk [Private Department of Rheumatology, Furesø-reumatologerne, Farum and ISMC, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Bispebjerg Bakke 23, 2. Tværvej, Indgang 8, 1. sal, 2400 København NV (Denmark); Højgaard, Betina, E-mail: beho@kora.dk [Danish Institute for Local and Regional Government Research, Købmagergade 22, 1150 København K (Denmark); Langberg, Henning, E-mail: henninglangberg@gmail.com [Institute of Social Medicine, Department of Public Health and Centre for Healthy Ageing, Faculty of Heath Sciences, University of Copenhagen, Øster Farimagsgade 5, bygn. 24, postboks 2099, 1014 København (Denmark)

    2015-03-15

    Objectives: To study prospectively whether structural changes determined by ultrasound scanning (US) can be used as prognostic markers for outcome in patients with symptomatic Achilles tendinopathy (AT) and to investigate whether there exists an association between US findings and pain measured by visual analog scale (VAS) and a general assessment score (GA). Methods: 92 consecutive patients with AT symptoms were recruited from two outpatient clinics in rheumatology. The patients underwent a conservative treatment protocol consisting of reduced activities, controlled rehabilitation including eccentric exercises of the calf muscles and if needed supplemented with corticosteroid injections. The patients were examined clinically and by US (tendon thickness, hyper- and hypoechogenicity, calcification, bursitis, calcaneusspure, tenosynovitis, gray scale and color Doppler focusing on increased flow intra- or peritendinous). The clinical and US examination were performed at entry, 1, 2, 3 and at 6 month. Results: 42 women and 50 men were included (mean age of 47 years). They had symptoms for more than 13 months and a symptomatic Achilles tendon mean thickness of 7.4 ± 2.3 mm. Heterogeneity at the initial examination was found to be a prognostic marker for the clinical outcome. Tendon thickness, hypoechogenicity and increased flow at any time point were significantly correlated to pain at function, palpatory pain and morning pain at the same time points. A reduction in tendon thickness was statistically associated with a decrease in palpatory pain. Conclusion: Heterogeneity is a prognostic marker in AT. Tendon thickness, hypoechogenicity and increased Doppler activity can be used as objective outcome parameters for the treatment effect of AT.

  13. Study of the high energy emission of accreting compact objects with SPI/INTEGRAL

    International Nuclear Information System (INIS)

    Droulans, R.

    2011-01-01

    The study of the high energy emission is essential for understanding the radiative processes inherent to accretion flows onto compact objects (black holes and neutron stars). The X/γ-ray continuum of these systems is successfully interpreted in terms of two components. The first component corresponds to blackbody emission from a geometrically thin optically thick accretion disk while the second component is generally associated to Compton scattering of the thermal disk flux off hot electrons. Despite considerable advances throughout the years, the heating mechanisms as well as the structure of the hot Comptonizing plasma remain poorly understood. In order to shed light on the physical processes that govern the innermost regions of the accretion flow, we take advantage of the data archive accumulated by the SPI instrument, a high energy spectrometer (20 keV - 8 MeV) developed at the CESR (now IRAP, Toulouse, France) for the INTEGRAL mission. Above 150 keV, SPI combines a unique spectral resolution with unequalled sensitivity, being thus an ideal tool to study the high energy emission of accreting compact objects. The thesis manuscript reports on the results of timing and spectral studies of three particular systems. First, I address the high energy emission of the enigmatic micro-quasar GRS 1915+105, a source characterized by colossal luminosity and strong chaotic variability in X-rays. On a timescale of about one day, the photon index of the 20 - 200 keV spectrum varies between 2.7 and 3.5; at higher energies (≥150 keV), SPI unveils the systematic presence of an additional emission component, extending without folding energy up to ∼ 500 keV. Second, I study the high energy emission of GX 339-4, a source whose spectral properties are representative of black hole transients. The spectrum of the luminous hard state of this system shows a variable high energy tail (≥150 keV), with significant flux changes on a short timescale (several hours). I explain the

  14. Mechanical Objects and the Engineering Learner: An Experimental Study of How the Presence of Objects Affects Students' Performance on Engineering Related Tasks

    Science.gov (United States)

    Bairaktarova, Diana N.

    2013-01-01

    People display varying levels of interaction with the mechanical objects in their environment; engineers in particular as makers and users of these objects display a higher level of interaction with them. Investigating the educational potential of mechanical objects in stimulating and supporting learning in engineering is warranted by the fact…

  15. Objectively measured physical activity and longitudinal changes in adolescent body fatness: an observational cohort study.

    Science.gov (United States)

    Collings, P J; Wijndaele, K; Corder, K; Westgate, K; Ridgway, C L; Sharp, S J; Atkin, A J; Stephen, A M; Bamber, D; Goodyer, I; Brage, S; Ekelund, U

    2016-04-01

    The data regarding prospective associations between physical activity (PA) and adiposity in youth are inconsistent. The objective of this study was to investigate associations between baseline levels of objectively measured PA and changes in adiposity over 2.5 years from mid-to-late adolescence. This was an observational cohort study in 728 school students (43% boys) from Cambridgeshire, United Kingdom. Fat mass index (FMI, kg m(-2) ) was estimated at baseline (mean ± standard deviation age: 15 ± 0.3 years) and follow-up (17.5 ± 0.3 years) by anthropometry and bioelectrical impedance. Habitual PA was assessed at baseline by ≥3 d combined heart rate and movement sensing. Average daily PA energy expenditure (PAEE) and the time (min d(-1) ) spent in light, moderate and vigorous intensity PA (LPA, MPA and VPA, respectively) was estimated. Multilevel models were used to investigate associations between baseline PA and change in FMI (ΔFMI). Adjustment for baseline age, sex, follow-up duration, area-level socioeconomic status, season of PA assessment, sedentary time, energy intake and sleep duration was made; baseline FMI was also added in a second model. FMI increased significantly over follow-up (0.6 ± 1.2 kg m(-2) , P positively predicted ΔFMI in overfat participants (P ≤ 0.030), as did VPA in initially normal fat participants (P ≤ 0.044). There were further positive associations between PAEE and ΔFMI in normal fat participants, and between MPA and ΔFMI in both fat groups, when adjusted for baseline FMI (P ≤ 0.024). Baseline PAEE and its subcomponents were positively associated with small and unlikely clinically relevant increases in ΔFMI. These counter-intuitive findings may be explained by behavioural changes during the course of study follow-up. © 2015 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity.

  16. RapidArc, intensity modulated photon and proton techniques for recurrent prostate cancer in previously irradiated patients: a treatment planning comparison study

    International Nuclear Information System (INIS)

    Weber, Damien C; Miralbell, Raymond; Wang, Hui; Cozzi, Luca; Dipasquale, Giovanna; Khan, Haleem G; Ratib, Osman; Rouzaud, Michel; Vees, Hansjoerg; Zaidi, Habib

    2009-01-01

    A study was performed comparing volumetric modulated arcs (RA) and intensity modulation (with photons, IMRT, or protons, IMPT) radiation therapy (RT) for patients with recurrent prostate cancer after RT. Plans for RA, IMRT and IMPT were optimized for 7 patients. Prescribed dose was 56 Gy in 14 fractions. The recurrent gross tumor volume (GTV) was defined on 18 F-fluorocholine PET/CT scans. Plans aimed to cover at least 95% of the planning target volume with a dose > 50.4 Gy. A maximum dose (D Max ) of 61.6 Gy was allowed to 5% of the GTV. For the urethra, D Max was constrained to 37 Gy. Rectal D Median was < 17 Gy. Results were analyzed using Dose-Volume Histogram and conformity index (CI 90 ) parameters. Tumor coverage (GTV and PTV) was improved with RA (V 95% 92.6 ± 7.9 and 83.7 ± 3.3%), when compared to IMRT (V 95% 88.6 ± 10.8 and 77.2 ± 2.2%). The corresponding values for IMPT were intermediate for the GTV (V 95% 88.9 ± 10.5%) and better for the PTV (V 95% 85.6 ± 5.0%). The percentages of rectal and urethral volumes receiving intermediate doses (35 Gy) were significantly decreased with RA (5.1 ± 3.0 and 38.0 ± 25.3%) and IMPT (3.9 ± 2.7 and 25.1 ± 21.1%), when compared to IMRT (9.8 ± 5.3 and 60.7 ± 41.7%). CI 90 was 1.3 ± 0.1 for photons and 1.6 ± 0.2 for protons. Integral Dose was 1.1 ± 0.5 Gy*cm 3 *10 5 for IMPT and about a factor three higher for all photon's techniques. RA and IMPT showed improvements in conformal avoidance relative to fixed beam IMRT for 7 patients with recurrent prostate cancer. IMPT showed further sparing of organs at risk

  17. Phase 2 study of tabalumab, a human anti-B-cell activating factor antibody, with bortezomib and dexamethasone in patients with previously treated multiple myeloma.

    Science.gov (United States)

    Raje, Noopur S; Moreau, Philippe; Terpos, Evangelos; Benboubker, Lotfi; Grząśko, Norbert; Holstein, Sarah A; Oriol, Albert; Huang, Shang-Yi; Beksac, Meral; Kuliczkowski, Kazimierz; Tai, Datchen F; Wooldridge, James E; Conti, Ilaria; Kaiser, Christopher J; Nguyen, Tuan S; Cronier, Damien M; Palumbo, Antonio

    2017-03-01

    In this double-blind, Phase 2 study, 220 patients with relapsed/refractory multiple myeloma were randomly assigned 1:1:1 to receive placebo (N = 72), tabalumab 100 mg (N = 74), or tabalumab 300 mg (N = 74), each in combination with dexamethasone 20 mg and subcutaneous bortezomib 1·3 mg/m 2 on a 21-day cycle. No significant intergroup differences were observed among primary (median progression-free survival [mPFS]) or secondary efficacy outcomes. The mPFS was 6·6, 7·5 and 7·6 months for the tabalumab 100, 300 mg and placebo groups, respectively (tabalumab 100 mg vs. placebo Hazard ratio (HR) [95% confidence interval (CI)] = 1·13 [0·80-1·59], P = 0·480; tabalumab 300 mg vs. placebo HR [95% CI] = 1·03 [0·72-1·45], P = 0·884). The most commonly-reported treatment-emergent adverse events were thrombocytopenia (37%), fatigue (37%), diarrhoea (35%) and constipation (32%). Across treatments, patients with low baseline BAFF (also termed TNFSF13B) expression (n = 162) had significantly longer mPFS than those with high BAFF expression (n = 55), using the 75th percentile cut-off point (mPFS [95% CI] = 8·3 [7·0-9·3] months vs. 5·8 [3·7-6·6] months; HR [95% CI] = 1·59 [1·11-2·29], P = 0·015). Although generally well tolerated, PFS was not improved during treatment with tabalumab compared to placebo. A higher dose of 300 mg tabalumab did not improve efficacy compared to the 100 mg dose. Nonetheless, BAFF appears to have some prognostic value in patients with multiple myeloma. © 2016 John Wiley & Sons Ltd.

  18. Gender Differences in Memory for Objects and Their Locations: A Study on Automatic versus Controlled Encoding and Retrieval Contexts

    Science.gov (United States)

    De Goede, Maartje; Postma, Albert

    2008-01-01

    Object-location memory is the only spatial task where female subjects have been shown to outperform males. This result is not consistent across all studies, and may be due to the combination of the multi-component structure of object location memory with the conditions under which different studies were done. Possible gender differences in object…

  19. Conscientious objection, barriers, and abortion in the case of rape: a study among physicians in Brazil.

    Science.gov (United States)

    Diniz, Debora; Madeiro, Alberto; Rosas, Cristião

    2014-05-01

    In Brazil, to have a legal abortion in the case of rape, the woman's statement that rape has occurred is considered sufficient to guarantee the right to abortion. The aim of this study was to understand the practice and opinions about providing abortion in the case of rape among obstetricians-gynecologists (OBGYNs) in Brazil. A mixed-method study was conducted from April to July 2012 with 1,690 OBGYNs who responded to a structured, electronic, self-completed questionnaire. In the quantitative phase, 81.6% of the physicians required police reports or judicial authorization to guarantee the care requested. In-depth telephone interviews with 50 of these physicians showed that they frequently tested women's rape claim by making them repeat their story to several health professionals; 43.5% of these claimed conscientious objection when they were uncertain whether the woman was telling the truth. The moral environment of illegal abortion alters the purpose of listening to a patient - from providing care to passing judgement on her. The data suggest that women's access to legal abortion is being blocked by these barriers in spite of the law. We recommend that FEBRASGO and the Ministry of Health work together to clarify to physicians that a woman's statement that rape occurred should allow her to access a legal abortion. Copyright © 2014 Reproductive Health Matters. Published by Elsevier Ltd. All rights reserved.

  20. Study of capability of microorganisms to develop on construction materials used in space objects

    Science.gov (United States)

    Rakova, N.; Svistunova, Y.; Novikova, N.

    One of the most topical issues nowadays in the whole set of space research is the study of microbiological risks (medical, technical, technological). Experiments held onboard MIR station and International Space Station (ISS) clearly demonstrated capacity of microorganisms to contaminate the environment, equipment and belonging of habitual compartments of space objects. In this connection microorganisms-biodestructors play an important role. In their vital functioning they are capable of causing biological damage of different polymers, biocorrosion of metals which can lead to serious difficulties in performing long-term flights, namely the planned mission to Mars. Our purpose was to study capability of growth and reproduction of microorganisms on construction materials of various chemical composition as the first stage of biodestruction process. In our research we used "flight" strains of bacteria (Bacillus subtilus, Staphylococcus epidermidis, Staphylococcus saprophyticus, Pseudomonas pumilus etc.) recovered from the ISS environment in several missions. For control we used "earth" bacteria species with typical properties. To model the environment of the ISS we took construction materials which are widely used in the interior and equipment of the ISS. The results we've obtained show that some microorganisms are capable of living and reproducing themselves on construction materials and their capability is more pronounced than that of the "earth" species. The best capability for growth and reproduction was characteristic of Bacillus subtilus.

  1. An analytical study of prehistoric lead and silver objects from the Aegean

    International Nuclear Information System (INIS)

    Pernicka, E.; Wagner, G.A.; Assimenos, K.; Doumas, C.; Begemann, F.; Todt, W.

    1983-01-01

    In the course of an archaeometallurgical study on the metal sources of archaic silver coinage it was discovered that lead-silver mines on the Cycladic island of Siphnos, which were known to Herodotus (III, 57) and exploited in archaic times, were already worked in the Early Bronze Age (EBA). In addition, new excavations in Thorikos have shown that the well-known lead-silver deposit of Laurion on Attika was also exploited as early as the EBA. In order to assess the role which these two mining districts and other possible ore sources played in the Bronze Age for the supply of lead and silver, we analyzed prehistoric lead and silver objects from the Aegean region. The methods employed were the same as have been used to characterize the ore deposits. In addition we wanted to study to what extent cupellation was practised in these early periods. Bulk composition and trace element concentrations were determined by instrumental and radiochemical neutron activation and atomic absorption spectrometry. Isotope abundance analyses were performed on a VARIAN MAT 261 mass spectrometer. Experimental details are given. Results are presented and discussed. (U.K.)

  2. Objectively measured sedentary time and physical activity in women with fibromyalgia: a cross-sectional study.

    Science.gov (United States)

    Ruiz, Jonatan R; Segura-Jiménez, Víctor; Ortega, Francisco B; Alvarez-Gallardo, Inmaculada C; Camiletti-Moirón, Daniel; Aparicio, Virginia A; Carbonell-Baeza, Ana; Femia, Pedro; Munguía-Izquierdo, Diego; Delgado-Fernández, Manuel

    2013-06-20

    To characterise levels of objectively measured sedentary time and physical activity in women with fibromyalgia. Cross-sectional study. Local Association of Fibromyalgia (Granada, Spain). The study comprised 94 women with diagnosed fibromyalgia who did not have other severe somatic or psychiatric disorders, or other diseases that prevent physical loading, able to ambulate and to communicate and capable and willing to provide informed consent. Sedentary time and physical activity were measured by accelerometry and expressed as time spent in sedentary behaviours, average physical activity intensity (counts/minute) and amount of time (minutes/day) spent in moderate intensity and in moderate-to-vigorous-intensity physical activity (MVPA). The proportion of women meeting the physical activity recommendations of 30 min/day of MVPA on 5 or more days a week was 60.6%. Women spent, on average, 71% of their waking time (approximately 10 h/day) in sedentary behaviours. Both sedentary behaviour and physical activity levels were similar across age groups, waist circumference and percentage body fat categories, years since clinical diagnosis, marital status, educational level and occupational status, regardless of the severity of the disease (all p>0.1). Time spent on moderate-intensity physical activity and MVPA was, however, lower in those with greater body mass index (BMI) (-6.6 min and -7 min, respectively, per BMI category increase, 30 kg/m(2); p values for trend were 0.056 and 0.051, respectively). Women spent, on average, 10 min less on MVPA (pfibromyalgia.

  3. Technical Objects between Categorisation and Learning: An Exploratory Case Study in French Middle School

    Science.gov (United States)

    Impedovo, M. A.; Andreucci, C.; Delserieys-Pedregosa, A.; Coiffard, C.; Ginestié, J.

    2015-01-01

    In this article we present exploratory research carried out in order to understand how students (from 12 to 14 years old) relate to technical objects. It uses technical objects that are part of everyday life and mediated reality. A questionnaire was administered to 57 students in French classes. The questionnaire was composed of three parts: 1)…

  4. Administration by Objectives: A Systematic Approach to Educational Planning in Virginia. Report of a Study.

    Science.gov (United States)

    Holmes, George W., III; Seawell, William H.

    This report presents (1) details of a program for educational administration by objectives and (2) the results of such a program developed by the Virginia State Department of Education to upgrade the quality of education in the public schools of that State. Administration by objectives is a systematic approach to education planning using…

  5. Human listening studies reveal insights into object features extracted by echolocating dolphins

    Science.gov (United States)

    Delong, Caroline M.; Au, Whitlow W. L.; Roitblat, Herbert L.

    2004-05-01

    Echolocating dolphins extract object feature information from the acoustic parameters of object echoes. However, little is known about which object features are salient to dolphins or how they extract those features. To gain insight into how dolphins might be extracting feature information, human listeners were presented with echoes from objects used in a dolphin echoic-visual cross-modal matching task. Human participants performed a task similar to the one the dolphin had performed; however, echoic samples consisting of 23-echo trains were presented via headphones. The participants listened to the echoic sample and then visually selected the correct object from among three alternatives. The participants performed as well as or better than the dolphin (M=88.0% correct), and reported using a combination of acoustic cues to extract object features (e.g., loudness, pitch, timbre). Participants frequently reported using the pattern of aural changes in the echoes across the echo train to identify the shape and structure of the objects (e.g., peaks in loudness or pitch). It is likely that dolphins also attend to the pattern of changes across echoes as objects are echolocated from different angles.

  6. Previously unknown species of Aspergillus.

    Science.gov (United States)

    Gautier, M; Normand, A-C; Ranque, S

    2016-08-01

    The use of multi-locus DNA sequence analysis has led to the description of previously unknown 'cryptic' Aspergillus species, whereas classical morphology-based identification of Aspergillus remains limited to the section or species-complex level. The current literature highlights two main features concerning these 'cryptic' Aspergillus species. First, the prevalence of such species in clinical samples is relatively high compared with emergent filamentous fungal taxa such as Mucorales, Scedosporium or Fusarium. Second, it is clearly important to identify these species in the clinical laboratory because of the high frequency of antifungal drug-resistant isolates of such Aspergillus species. Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) has recently been shown to enable the identification of filamentous fungi with an accuracy similar to that of DNA sequence-based methods. As MALDI-TOF MS is well suited to the routine clinical laboratory workflow, it facilitates the identification of these 'cryptic' Aspergillus species at the routine mycology bench. The rapid establishment of enhanced filamentous fungi identification facilities will lead to a better understanding of the epidemiology and clinical importance of these emerging Aspergillus species. Based on routine MALDI-TOF MS-based identification results, we provide original insights into the key interpretation issues of a positive Aspergillus culture from a clinical sample. Which ubiquitous species that are frequently isolated from air samples are rarely involved in human invasive disease? Can both the species and the type of biological sample indicate Aspergillus carriage, colonization or infection in a patient? Highly accurate routine filamentous fungi identification is central to enhance the understanding of these previously unknown Aspergillus species, with a vital impact on further improved patient care. Copyright © 2016 European Society of Clinical Microbiology and

  7. A case Study of Applying Object-Relational Persistence in Astronomy Data Archiving

    Science.gov (United States)

    Yao, S. S.; Hiriart, R.; Barg, I.; Warner, P.; Gasson, D.

    2005-12-01

    The NOAO Science Archive (NSA) team is developing a comprehensive domain model to capture the science data in the archive. Java and an object model derived from the domain model weil address the application layer of the archive system. However, since RDBMS is the best proven technology for data management, the challenge is the paradigm mismatch between the object and the relational models. Transparent object-relational mapping (ORM) persistence is a successful solution to this challenge. In the data modeling and persistence implementation of NSA, we are using Hibernate, a well-accepted ORM tool, to bridge the object model in the business tier and the relational model in the database tier. Thus, the database is isolated from the Java application. The application queries directly on objects using a DBMS-independent object-oriented query API, which frees the application developers from the low level JDBC and SQL so that they can focus on the domain logic. We present the detailed design of the NSA R3 (Release 3) data model and object-relational persistence, including mapping, retrieving and caching. Persistence layer optimization and performance tuning will be analyzed. The system is being built on J2EE, so the integration of Hibernate into the EJB container and the transaction management are also explored.

  8. Neuronal encoding of object and distance information: A model simulation study on naturalistic optic flow processing

    Directory of Open Access Journals (Sweden)

    Patrick eHennig

    2012-03-01

    Full Text Available We developed a model of the input circuitry of the FD1 cell, an identified motion-sensitive interneuron in the blowfly’s visual system. The model circuit successfully reproduces the FD1 cell’s most conspicuous property: Its larger responses to objects than to spatially extended patterns. The model circuit also mimics the time-dependent responses of FD1 to dynamically complex naturalistic stimuli, shaped by the blowfly’s saccadic flight and gaze strategy: The FD1 responses are enhanced when, as a consequence of self-motion, a nearby object crosses the receptive field during intersaccadic intervals. Moreover, the model predicts that these object-induced responses are superimposed by pronounced pattern-dependent fluctuations during movements on virtual test flights in a three-dimensional environment with systematic modifications of the environmental patterns. Hence, the FD1 cell is predicted to detect not unambiguously objects defined by the spatial layout of the environment, but to be also sensitive to objects distinguished by textural features. These ambiguous detection abilities suggest an encoding of information about objects - irrespective of the features by which the objects are defined - by a population of cells, with the FD1 cell presumably playing a prominent role in such an ensemble.

  9. Review of previous geophysical and geological studies

    Digital Repository Service at National Institute of Oceanography (India)

    Levchenko, O.V.; Neprochnov, Y.P; Rao, D.G; Subrahmanyam, C.; Murthy, K.S

    stream_size 5 stream_content_type text/plain stream_name Mem_Geol_Soc_India_39_5.pdf.txt stream_source_info Mem_Geol_Soc_India_39_5.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  10. Virtual power plant feasibility study and funding proposal / the virtual power plant objectives, concept, components, context, business plan / objectives, activities and timelines for the VPP feasibility study

    International Nuclear Information System (INIS)

    MacDonald, A.

    2004-01-01

    This paper presents a proposal for funding a virtual power plant feasibility study. The goals of the virtual power plant are to increase the efficiency of electricity use by creating a market-driven, subsidy-free, financially sustainable mechanism to finance economic Demand Side Management (DSM) by providing a fully liquid market for saved electricity, provide a new revenue opportunity for the Local Distributing Company (LDC) and increase the use of renewable and low environmental impact, high efficiency technologies within the service area

  11. A Case Study on Coloured Petri Nets in Object-oriented Analysis and Design

    DEFF Research Database (Denmark)

    Barros, Joao Paulo; Jørgensen, Jens Bæk

    2005-01-01

    is structurally and conceptually closer to class diagrams and object-oriented programming languages. The CPN models reduce the gap between user-level requirements and the respective implementation, thus simplifying the implementation or code generation. Finally, we discuss the code generation from object-oriented......In this paper, we first demonstrate how a coloured Petri nets (CPN) model can be used to capture requirements for a considered example system, an elevator controller. Then, we show how this requirements-level CPN model is transformed into a design-level object-oriented CPN model, which...

  12. Object-based encoding in visual working memory: a life span study.

    Science.gov (United States)

    Zhang, Qiong; Shen, Mowei; Tang, Ning; Zhao, Guohua; Gao, Zaifeng

    2013-08-20

    Recent studies on development of visual working memory (VWM) predominantly focus on VWM capacity and spatial-based information filtering in VWM. Here we explored another new aspect of VWM development: object-based encoding (OBE), which refers to the fact that even if one feature dimension is required to be selected into VWM, the other irrelevant dimensions are also extracted. We explored the OBE in children, young adults, and old adults, by probing an "irrelevant-change distracting effect" in which a change of stored irrelevant feature dramatically affects the performance of task-relevant features in a change-detection task. Participants were required to remember two or four simple colored shapes, while color was used as the relevant dimension. We found that changes to irrelevant shapes led to a significant distracting effect across the three age groups in both load conditions; however, children showed a greater degree of OBE than did young and old adults. These results suggest that OBE exists in VWM over the life span (6-67 years), yet continues to develop along with VWM.

  13. A Study of Planetary Nebulae using the Faint Object Infrared Camera for the SOFIA Telescope

    Science.gov (United States)

    Davis, Jessica

    2012-01-01

    A planetary nebula is formed following an intermediate-mass (1-8 solar M) star's evolution off of the main sequence; it undergoes a phase of mass loss whereby the stellar envelope is ejected and the core is converted into a white dwarf. Planetary nebulae often display complex morphologies such as waists or torii, rings, collimated jet-like outflows, and bipolar symmetry, but exactly how these features form is unclear. To study how the distribution of dust in the interstellar medium affects their morphology, we utilize the Faint Object InfraRed CAmera for the SOFIA Telescope (FORCAST) to obtain well-resolved images of four planetary nebulae--NGC 7027, NGC 6543, M2-9, and the Frosty Leo Nebula--at wavelengths where they radiate most of their energy. We retrieve mid infrared images at wavelengths ranging from 6.3 to 37.1 micron for each of our targets. IDL (Interactive Data Language) is used to perform basic analysis. We select M2-9 to investigate further; analyzing cross sections of the southern lobe reveals a slight limb brightening effect. Modeling the dust distribution within the lobes reveals that the thickness of the lobe walls is higher than anticipated, or rather than surrounding a vacuum surrounds a low density region of tenuous dust. Further analysis of this and other planetary nebulae is needed before drawing more specific conclusions.

  14. Objectively recorded physical activity in early pregnancy: a multiethnic population-based study.

    Science.gov (United States)

    Berntsen, S; Richardsen, K R; Mørkrid, K; Sletner, L; Birkeland, K I; Jenum, A K

    2014-06-01

    This study aimed to compare objectively recorded physical activity (PA) levels and walking steps among pregnant women. Cross-sectional data from a multiethnic cohort (n = 823) of pregnant women consisting of 44% from Western countries, 24% from South Asia, 14% from Middle East, and 18% from other countries. PA and steps were recorded by the activity monitor SenseWear™ Pro3 Armband. A total of 678 women were included in the analysis. Western women walked significantly more steps and had higher moderate-to-vigorous-intensity physical activity (MVPA) levels compared with South Asian women per weekday and weekend day. Interaction terms (P = 0.008) between ethnicity (Western vs South Asian) and parity, and education, respectively, were identified: having ≥ 1 children was positively associated with steps during weekends in South Asians in contrast to Western women. Having pregnancy and South Asian women without children and with higher education may have an elevated risk for an inactive lifestyle during pregnancy. © 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. Impact of iterative reconstructions on objective and subjective emphysema assessment with computed tomography: a prospective study

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Steve P.; Gariani, Joanna; Hachulla, Anne-Lise; Botsikas, Diomidis; Becker, Christoph D.; Montet, Xavier [Geneva University Hospitals, Division of Radiology, Department of Imaging and Medical Information Sciences, Geneva (Switzerland); Adler, Dan [Geneva University Hospitals, Division of Pneumology, Department of Internal Medicine, Geneva (Switzerland); Karenovics, Wolfram [Geneva University Hospitals, Division of Thoracic Surgery, Department of Surgery, Geneva (Switzerland)

    2017-07-15

    To prospectively evaluate the impact of iterative reconstruction (IR) algorithms on pulmonary emphysema assessment as compared to filtered back projection (FBP). One hundred ten unenhanced chest CT examinations were obtained on two different scanners. Image reconstructions from a single acquisition were done with different levels of IR and compared with FBP on the basis of the emphysema index (EI), lung volume and voxel densities. Objective emphysema assessment was performed with 3D software provided by each manufacturer. Subjective assessment of emphysema was performed as a blinded evaluation. Quantitative and subjective values were compared using repeated ANOVA analysis, Bland-Altman analysis and Kendall's coefficient of concordance (W). Lung volumes are stable on both units, throughout all IR levels (P ≥ 0.057). EI significantly decreases on both units with the use of any level of IR (P < 0.001). The highest levels of IR are responsible for a decrease of 33-36 % of EI. Significant differences in minimal lung density are found between the different algorithms (P < 0.003). Intra- and inter-reader concordance for emphysema characterisation is generally good (W ≥ 0.77 and W ≥ 0.86, respectively). Both commercially available IR algorithms used in this study significantly changed EI but did not alter visual assessment compared to standard FBP reconstruction at identical radiation exposure. (orig.)

  16. Cognitive development in kittens (Felis catus): an observational study of object permanence and sensorimotor intelligence.

    Science.gov (United States)

    Dumas, C; Doré, F Y

    1991-12-01

    Spontaneous behavior of kittens (Felis catus) was filmed from birth until the end of Month 5 and coded according to Piagetian criteria of sensorimotor intelligence (SI) and object permanence (OP). Data revealed that Stages 2, 3, and 4 of SI were reached at Days 10, 26, and 45, respectively, whereas Stages 2, 3, and 4 of OP were reached at Days 31, 37, and 41, respectively. Spontaneous search behavior was exhibited both in searching for an object that disappeared and in hiding while moving toward a target object. From Day 45 on, search behavior was integrated into a playful social interaction in the form of hide-and-seek. Hence, kittens' spontaneous activity provided them with contexts in which OP was necessary for activity. Lastly, it is proposed that the mobility of both social and physical objects triggered circular activity in this species.

  17. Concepts and collections: A case study using objects from the Brooklyn Museum

    DEFF Research Database (Denmark)

    Wray, Tim; Eklund, Peter

    2011-01-01

    In this paper, we present a browsing framework for digitised cultural collections. Using a data analysis technique called Formal Concept Analysis (FCA), units of thought can be constructed from a series of objects and their tags. FCA can dynamically generate links in between objects and induce...... a serendipitous browsing experience using a relatively simple data structure. We evaluate the utility and scalability of our approach to a collection of 15,000 objects from the Brooklyn Museum's collections. We describe how we use natural language processing techniques and external lexical resources to synthesise...... key terms from museum documentation. We then combine this term extraction process with FCA to effectively demonstrate links between and within collections of objects. In doing so we present a versatile, generalizable term extraction and browsing framework suitable for digital libraries and archives...

  18. Objectively Measured Physical Activity and Sedentary Time during Childhood, Adolescence and Young Adulthood: A Cohort Study

    Science.gov (United States)

    Ortega, Francisco B.; Hurtig-Wennlöf, Anita; Mäestu, Jarek; Löf, Marie; Harro, Jaanus; Bellocco, Rino; Labayen, Idoia; Veidebaum, Toomas; Sjöström, Michael

    2013-01-01

    Background To know how moderate-to-vigorous physical activity (MVPA) and sedentary time change across lifespan periods is needed for designing successful lifestyle interventions. We aimed to study changes in objectively measured (accelerometry) MVPA and sedentary time from childhood to adolescence and from adolescence to young adulthood. Methods Estonian and Swedish participants from the European Youth Heart Study aged 9 and 15 years at baseline (N = 2312) were asked to participate in a second examination 6 (Sweden) to 9/10 (Estonia) years later. 1800 participants with valid accelerometer data were analyzed. Results MVPA decreased from childhood to adolescence (−1 to −2.5 min/d per year of follow-up, P = 0.01 and girls and boys respectively) and also from adolescence to young adulthood (−0.8 to −2.2 min/d per year, P = 0.02 and girls and boys, respectively). Sedentary time increased from childhood to adolescence (+15 and +20 min/d per year, for girls and boys respectively, Pboys than in girls. The magnitude of the change observed in sedentary time was 3–6 time larger than the change observed in MVPA. Conclusions The decline in MVPA (overall change = 30 min/d) and increase sedentary time (overall change = 2∶45 h/d) observed from childhood to adolescence are of concern and might increase the risk of developing obesity and other chronic diseases later in life. These findings substantially contribute to understand how key health-related behaviors (physical activity and sedentary) change across important periods of life. PMID:23637772

  19. Expression of the Objectives of Interactive Electoral Communication: The Study of 2011 Municipal Council Elections

    OpenAIRE

    Šuminas, Andrius

    2011-01-01

    The process of interactive electoral communication initiated by politicians in social media is the object of the dissertation. The aim of the paper is to develop a comprehensive research approach to politicians’ electoral communication in social media and to use the approach in describing the specificity of electoral communication taking place in social media, determining the features of expression of the candidates’ electoral objectives, and making an analysis of the communication that took ...

  20. Mental rotation versus invariant features in object perception from different viewpoints: An fMRI study

    OpenAIRE

    Vanrie, Jan; Béatse, Erik; Wagemans, Johan; Sunaert, Stefan; Van Hecke, Paul

    2002-01-01

    It has been proposed that object perception can proceed through different routes, which can be situated on a continuum ranging from complete viewpoint-dependency to complete viewpoint-independency, depending on the objects and the task at hand. Although these different routes have been extensively demonstrated on the behavioral level, the corresponding distinction in the underlying neural substrate has not received the same attention. Our goal was to disentangle, on the behavioral and the neu...

  1. Multi-Objective Sensitivity Analyses for Power Generation Mix: Malaysia Case Study

    OpenAIRE

    Siti Mariam Mohd Shokri; Nofri Yenita Dahlan; Hasmaini Mohamad

    2017-01-01

    This paper presents an optimization framework to determine long-term optimal generation mix for Malaysia Power Sector using Dynamic Programming (DP) technique. Several new candidate units with a pre-defined MW capacity were included in the model for generation expansion planning from coal, natural gas, hydro and renewable energy (RE). Four objective cases were considered, 1) economic cost, 2) environmental, 3) reliability and 4) multi-objectives that combining the three cases. Results show th...

  2. Does real-time objective feedback and competition improve performance and quality in manikin CPR training--a prospective observational study from several European EMS.

    Science.gov (United States)

    Smart, J R; Kranz, K; Carmona, F; Lindner, T W; Newton, A

    2015-10-15

    Previous studies have reported that the quality of cardiopulmonary resuscitation (CPR) is important for patient survival. Real time objective feedback during manikin training has been shown to improve CPR performance. Objective measurement could facilitate competition and help motivate participants to improve their CPR performance. The aims of this study were to investigate whether real time objective feedback on manikins helps improve CPR performance and whether competition between separate European Emergency Medical Services (EMS) and between participants at each EMS helps motivation to train. Ten European EMS took part in the study and was carried out in two stages. At Stage 1, each EMS provided 20 pre-hospital professionals. A questionnaire was completed and standardised assessment scenarios were performed for adult and infant out of hospital cardiac arrest (OHCA). CPR performance was objectively measured and recorded but no feedback given. Between Stage 1 and 2, each EMS was given access to manikins for 6 months and instructed on how to use with objective real-time CPR feedback available. Stage 2 was undertaken and was a repeat of Stage 1 with a questionnaire with additional questions relating to usefulness of feedback and the competition nature of the study (using a 10 point Likert score). The EMS that improved the most from Stage 1 to Stage 2 was declared the winner. An independent samples Student t-test was used to analyse the objective CPR metrics with the significance level taken as p Competition between EMS organisations recorded a mean score of 5.8 and competition between participants recorded a mean score of 6.0. The results suggest that the use of real time objective feedback can significantly help improve CPR performance. Competition, especially between participants, appeared to encourage staff to practice and this study suggests that competition might have a useful role to help motivate staff to perform CPR training.

  3. Objectives and Indexes for Implementation of Sponge Cities—A Case Study of Changzhou City, China

    Directory of Open Access Journals (Sweden)

    Zhengzhao Li

    2018-05-01

    Full Text Available This paper presents a framework of objectives and indexes for sponge cities implementation in China. The proposed objectives and indexes aims to reflect whether the city is in accord with the sponge city. Different cities have different objectives and indexes as each city has its own geologic and hydrogeological conditions. Therefore, the main problems (e.g., water security and flood risks in the central urban area of Changzhou city, China were evaluated scientifically. According to the local conditions, four objectives and eleven indexes have been made as a standard to estimate the sponge city and set a goal for the city development to reach the goal of sustainable urban development. The strategy of process control was implemented to improve the standard of urban drainage and flood control facilities, regulate total runoff and reduce storm peak flow, and the ecological monitoring of the function of the rivers and lakes. The objectives of sponge cities include water security, water quality improvement, healthy water ecosystems, and water utilization efficiency. Urban flood prevention capacity, river and lake water quality compliance, and annual runoff control are the key objectives to encourage the use of non-conventional water resources.

  4. The Role of Shape in Semantic Memory Organization of Objects: An Experimental Study Using PI-Release.

    Science.gov (United States)

    van Weelden, Lisanne; Schilperoord, Joost; Swerts, Marc; Pecher, Diane

    2015-01-01

    Visual information contributes fundamentally to the process of object categorization. The present study investigated whether the degree of activation of visual information in this process is dependent on the contextual relevance of this information. We used the Proactive Interference (PI-release) paradigm. In four experiments, we manipulated the information by which objects could be categorized and subsequently be retrieved from memory. The pattern of PI-release showed that if objects could be stored and retrieved both by (non-perceptual) semantic and (perceptual) shape information, then shape information was overruled by semantic information. If, however, semantic information could not be (satisfactorily) used to store and retrieve objects, then objects were stored in memory in terms of their shape. The latter effect was found to be strongest for objects from identical semantic categories.

  5. A previous hamstring injury affects kicking mechanics in soccer players.

    Science.gov (United States)

    Navandar, Archit; Veiga, Santiago; Torres, Gonzalo; Chorro, David; Navarro, Enrique

    2018-01-10

    Although the kicking skill is influenced by limb dominance and sex, how a previous hamstring injury affects kicking has not been studied in detail. Thus, the objective of this study was to evaluate the effect of sex and limb dominance on kicking in limbs with and without a previous hamstring injury. 45 professional players (males: n=19, previously injured players=4, age=21.16 ± 2.00 years; females: n=19, previously injured players=10, age=22.15 ± 4.50 years) performed 5 kicks each with their preferred and non-preferred limb at a target 7m away, which were recorded with a three-dimensional motion capture system. Kinematic and kinetic variables were extracted for the backswing, leg cocking, leg acceleration and follow through phases. A shorter backswing (20.20 ± 3.49% vs 25.64 ± 4.57%), and differences in knee flexion angle (58 ± 10o vs 72 ± 14o) and hip flexion velocity (8 ± 0rad/s vs 10 ± 2rad/s) were observed in previously injured, non-preferred limb kicks for females. A lower peak hip linear velocity (3.50 ± 0.84m/s vs 4.10 ± 0.45m/s) was observed in previously injured, preferred limb kicks of females. These differences occurred in the backswing and leg-cocking phases where the hamstring muscles were the most active. A variation in the functioning of the hamstring muscles and that of the gluteus maximus and iliopsoas in the case of a previous injury could account for the differences observed in the kicking pattern. Therefore, the effects of a previous hamstring injury must be considered while designing rehabilitation programs to re-educate kicking movement.

  6. The role of farmers’ objectives in current farm practices and adaptation preferences: a case study in Flevoland, the Netherlands

    NARCIS (Netherlands)

    Mandryk, M.; Reidsma, P.; Kanellopoulos, A.; Groot, J.C.J.; Ittersum, van M.K.

    2014-01-01

    The diversity in farmers’ objectives and responses to external drivers is usually not considered in integrated assessment studies that investigate impacts and adaptation to climate and socio-economic change. Here, we present an approach to assess how farmers’ stated objectives relate to their

  7. Long-term integrated radiophysical studies of the ionosphere, near space, and the propagation of radio waves from space objects

    Science.gov (United States)

    Misyura, V. A.

    1974-01-01

    The radiophysical studies reported consist of direct measurements of certain effects induced in the propagation of radio waves from space objects. From measured effects and from data on the motion and position of space objects, physical parameters of the medium and bodies are determined.

  8. Video Cases in Teacher Education: A review study on intended and achieved learning objectives by video cases

    NARCIS (Netherlands)

    Geerts, Walter; Van der Werff, Anne; Hummel, Hans; Van Geert, Paul

    2014-01-01

    This literature review focuses on the use of video cases in the education of preservice teachers as a means of achieving higher order learning objectives that are necessary for gaining situated knowledge. An overview of both intended and achieved learning objectives in relevant studies involving

  9. Predictive value of object relations for therapeutic alliance and outcome in psychotherapy for depression: an exploratory study

    NARCIS (Netherlands)

    Van, H.L.; Hendriksen, M.; Schoevers, R.A.; Peen, J.; Abraham, R.A.; Dekker, J.J.M.

    2008-01-01

    The concept of object relations has been shown to be relevant for the process and outcome of psychodynamic psychotherapies. However, little is known about its relevance for the psychotherapeutic treatment of depression. In this study, we explored the predictive value of object relational functioning

  10. Exploring Preschoolers' Engagement and Perceived Physical Competence in an Autonomy-Based Object Control Skill Intervention: A Preliminary Study

    Science.gov (United States)

    Logan, Samuel; Robinson, Leah; Webster, E. Kipling; Barber, Laura

    2013-01-01

    The purpose of this study was to describe children's engagement during two (high and low) autonomy-based climates. Twenty-five preschool children participated in a nine-week object control skill intervention. Children completed the object control subscale of the Test of Gross Motor Development 2nd Edition and the perceived physical competence…

  11. Preoperative screening: value of previous tests.

    Science.gov (United States)

    Macpherson, D S; Snow, R; Lofgren, R P

    1990-12-15

    To determine the frequency of tests done in the year before elective surgery that might substitute for preoperative screening tests and to determine the frequency of test results that change from a normal value to a value likely to alter perioperative management. Retrospective cohort analysis of computerized laboratory data (complete blood count, sodium, potassium, and creatinine levels, prothrombin time, and partial thromboplastin time). Urban tertiary care Veterans Affairs Hospital. Consecutive sample of 1109 patients who had elective surgery in 1988. At admission, 7549 preoperative tests were done, 47% of which duplicated tests performed in the previous year. Of 3096 previous results that were normal as defined by hospital reference range and done closest to the time of but before admission (median interval, 2 months), 13 (0.4%; 95% CI, 0.2% to 0.7%), repeat values were outside a range considered acceptable for surgery. Most of the abnormalities were predictable from the patient's history, and most were not noted in the medical record. Of 461 previous tests that were abnormal, 78 (17%; CI, 13% to 20%) repeat values at admission were outside a range considered acceptable for surgery (P less than 0.001, frequency of clinically important abnormalities of patients with normal previous results with those with abnormal previous results). Physicians evaluating patients preoperatively could safely substitute the previous test results analyzed in this study for preoperative screening tests if the previous tests are normal and no obvious indication for retesting is present.

  12. Introducing the HOPE (Hypospadias Objective Penile Evaluation)-score : A validation study of an objective scoring system for evaluating cosmetic appearance in hypospadias patients

    NARCIS (Netherlands)

    van der Toorn, Fred; de Jong, Tom P. V. M.; de Gier, Robert P. E.; Callewaert, Piet R. H.; van der Horst, Eric H. J. R.; Steffens, Martijn G.; Hoebeke, Piet; Nijman, Rien J. M.; Bush, Nicol C.; Wolffenbuttel, Katja P.; van den Heijkant, Marleen M. C.; van Capelle, Jan-Willem; Wildhagen, Mark; Timman, Reinier; van Busschbach, Jan J. V.

    2013-01-01

    Objective: To determine the reliability and internal validity of the Hypospadias Objective Penile Evaluation (HOPE)-score, a newly developed scoring system assessing the cosmetic outcome in hypospadias. Patients and methods: The HOPE scoring system incorporates all surgically-correctable items:

  13. The Role of Presented Objects in Deriving Color Preference Criteria from Psychophysical Studies

    Energy Technology Data Exchange (ETDEWEB)

    Royer, Michael P.; Wei, Minchen

    2016-12-08

    Of the many “components” of a color rendering measure, one is perhaps the most important: the set of color samples (spectral reflectance functions) that are employed as a standardized means of evaluating and rating a light source. At the same time, a standardized set of color samples can never apply perfectly to a real space or a real set of observed objects, meaning there will always be some level of mismatch between the predicted and observed color shifts. This mismatch is important for lighting specifiers to consider, but even more critical for experiments that seek to evaluate the relationship between color rendering measures and human perception. This article explores how the color distortions of three possible experimental object sets compare to the color distortions predicted using the color evaluation samples of IES TM-30-15 (TM-30). The experimental object sets include those from Royer and colleagues [2016], a set of produce (10 fruits and vegetables), and the X-rite Color Checker Classic. The differences are traced back to properties of the samples sets, such as the coverage of color space, average chroma level, and specific spectral features. The consequence of the differences, that the visual evaluation is based on color distortions that are substantially different from what is predicted, can lead to inaccurate criteria or models of a given perception, such as preference. To minimize the error in using criteria or models when specifying color rendering attributes for a given application, the criteria or models should be developed using a set of experimental objects that matches the typical objects of the application as closely as possible. Alternatively, if typical objects of an application cannot be reasonably determined, an object set that matches the distortions predicted by TM-30 as close as possible is likely to provide the most meaningful results.

  14. Real-time objects development: Study and proposal for a parallel scheduling architecture

    International Nuclear Information System (INIS)

    Rioux, Laurent

    1997-01-01

    This thesis contributes to the programming and the execution control of real-time object oriented applications. Using real-time objects is very interesting for programming real- time applications, because this model can introduce the concurrence with the encapsulation properties, with modularity and reusability by taking into account the real-time constraints of the application. One essential quality of this approach is that it can directly specify the parallelism and the real-time constraints at the model level of the application. An annotation system of C++ has been defined to describe the real-time specifications in the model (or in the source code) of the application. It will supply to the execution support the different information it needs for the control. In this approach of multitasking, the control is distributed and encapsulated inside each real time object. Three complementary levels of control have been defined: the state level (defining the capability of an object to treat an operation), the concurrence level (assuring the coherence between the object attributes) and a scheduling control (allocating the processors resources to the object by taking real-time constraints into account). The proposed control architecture, named OROS, manages the attribute access of each object in an individual way, then it can parallel treatments which do not access at the same data. This architecture makes a dynamic control of an application that can take benefit from the parallelism of the new machines both for the execution parallelism and the control itself. This architecture uses only the simplest primitives of the industrial real-time operating systems which ensures its feasibility and portability. (author) [fr

  15. Studies on Romanian archaeological objects using nuclear methods: cases of Pietroasa hoard and Cucuteni ceramics

    International Nuclear Information System (INIS)

    Constantinescu, B.; Cojocaru, V.; Bugoi, R.; Dumitriu, D.E.; Grambole, D.; Herrmann, F.; Secleman, D.; Popovici, M.

    2003-01-01

    The study of trace-elements in archaeological metallic objects can provide important clues about the metal provenance and the involved manufacturing procedures, leading to important conclusions regarding the commercial, cultural and religious exchanges between the antique populations. Ancient metallic materials are usually inhomogeneous on a scale of 20 microns or less: they contain remains of imperfect smelting, segregated phases in alloys, inclusions. Due to their exceptional chemical stability, gold artifacts remain essentially unchanged during weathering and aging processes. Several fragments of ancient gold objects coming from an Eneolithic treasury and from Pietroasa 'Closca cu Puii de Aur' ('The Golden Brood Hen with Its Chickens') hoard, unearthed on Romanian territory and two Romanian native gold nuggets samples were analyzed using micro-PIXE technique at the Rossendorf TANDETRON microbeam facility. The purpose of the study was to clarify the metal provenance, establishing if the hypothesis of local gold holds. To reach this goal, trace elements (Cu, Te, Sn, Pb, Hg, As, Zr, Sb) and PGE (Platinum Group Elements) concentrations were determined. The presence of inclusions (micrometric size areas of composition different from the surroundings) was also checked. We found some Si, Ca, Fe ones on two Eneolithic samples, and a Ta-Cr one on a sample from Pietroasa hoard. The measurements led to conclusions regarding the alluvial origin of the gold for the Eneolithic samples and gave some indications for the possible gold ore sources of Pietroasa treasury - Urals mountains and north-eastern Turkey, confirming the heterogeneity of this treasury (the two analyzed pieces belonged to different stylistic and compositional groups). Synchrotron Radiation X-Ray Powder Diffraction was used at MAXLAB synchrotron (Lund, Sweden) to distinguish different clays and mineral pigments of various neolithic pottery-producing centres on Romanian territory. As main results we can be

  16. Sudden unexpected death in children with a previously diagnosed cardiovascular disorder

    NARCIS (Netherlands)

    Polderman, Florens N.; Cohen, Joeri; Blom, Nico A.; Delhaas, Tammo; Helbing, Wim A.; Lam, Jan; Sobotka-Plojhar, Marta A.; Temmerman, Arno M.; Sreeram, Narayanswani

    2004-01-01

    BACKGROUND: It is known that children with previously diagnosed heart defects die suddenly. The causes of death are often unknown. OBJECTIVE: The aim of the study was to identify all infants and children within the Netherlands with previously diagnosed heart disease who had a sudden unexpected death

  17. Sudden unexpected death in children with a previously diagnosed cardiovascular disorder

    NARCIS (Netherlands)

    Polderman, F.N.; Cohen, Joeri; Blom, N.A.; Delhaas, T.; Helbing, W.A.; Lam, J.; Sobotka-Plojhar, M.A.; Temmerman, Arno M.; Sreeram, N.

    2004-01-01

    Background: It is known that children with previously diagnosed heart defects die suddenly. The causes of death are often unknown. Objective: The aim of the study was to identify all infants and children within the Netherlands with previously diagnosed heart disease who had a sudden unexpected death

  18. An Intelligent Systems Approach to Automated Object Recognition: A Preliminary Study

    Science.gov (United States)

    Maddox, Brian G.; Swadley, Casey L.

    2002-01-01

    Attempts at fully automated object recognition systems have met with varying levels of success over the years. However, none of the systems have achieved high enough accuracy rates to be run unattended. One of the reasons for this may be that they are designed from the computer's point of view and rely mainly on image-processing methods. A better solution to this problem may be to make use of modern advances in computational intelligence and distributed processing to try to mimic how the human brain is thought to recognize objects. As humans combine cognitive processes with detection techniques, such a system would combine traditional image-processing techniques with computer-based intelligence to determine the identity of various objects in a scene.

  19. Optical and infrared study of the region surrounding Herbig-Haro objects 1 and 2

    International Nuclear Information System (INIS)

    Strom, S.E.; Strom, K.M.; Grasdalen, G.L.; Sellgren, K.; Wolff, S.; Wyoming Univ., Laramie; Hawaii Univ., Honolulu)

    1985-01-01

    Optical and near-IR observations of the environs of H-H objects 1 and 2 provide the basis for identifying a recently discovered radio continuum as the star responsible for powering the highly collimated mass outflow traced by these objects. Polarimetric observations show that the source (designated as VLA 1), located at the midpoint between HH 1 and 2, illuminates a biconical reflection nebula. It is suggested that VLA 1 is probably surrounded by an optically thick disk viewed edge on; an optical jet emanates from the vicinity of HH 1 and is directed along the axis of the putative disk toward HH 1; its spectrum resembles that of HH 1 and other Herbig-Haro objects. 37 references

  20. Golimumab in patients with active rheumatoid arthritis who have previous experience with tumour necrosis factor inhibitors: results of a long-term extension of the randomised, double-blind, placebo-controlled GO-AFTER study through week 160

    NARCIS (Netherlands)

    Smolen, Josef S.; Kay, Jonathan; Landewé, Robert B. M.; Matteson, Eric L.; Gaylis, Norman; Wollenhaupt, Jurgen; Murphy, Frederick T.; Zhou, Yiying; Hsia, Elizabeth C.; Doyle, Mittie K.

    2012-01-01

    The aim of this study was to assess long-term golimumab therapy in patients with rheumatoid arthritis (RA) who discontinued previous tumour necrosis factor alpha (TNFα) inhibitor(s) for any reason. Results through week 24 of this multicentre, randomised, double-blind, placebo-controlled study of

  1. Comparative study of SVM methods combined with voxel selection for object category classification on fMRI data.

    Science.gov (United States)

    Song, Sutao; Zhan, Zhichao; Long, Zhiying; Zhang, Jiacai; Yao, Li

    2011-02-16

    Support vector machine (SVM) has been widely used as accurate and reliable method to decipher brain patterns from functional MRI (fMRI) data. Previous studies have not found a clear benefit for non-linear (polynomial kernel) SVM versus linear one. Here, a more effective non-linear SVM using radial basis function (RBF) kernel is compared with linear SVM. Different from traditional studies which focused either merely on the evaluation of different types of SVM or the voxel selection methods, we aimed to investigate the overall performance of linear and RBF SVM for fMRI classification together with voxel selection schemes on classification accuracy and time-consuming. Six different voxel selection methods were employed to decide which voxels of fMRI data would be included in SVM classifiers with linear and RBF kernels in classifying 4-category objects. Then the overall performances of voxel selection and classification methods were compared. Results showed that: (1) Voxel selection had an important impact on the classification accuracy of the classifiers: in a relative low dimensional feature space, RBF SVM outperformed linear SVM significantly; in a relative high dimensional space, linear SVM performed better than its counterpart; (2) Considering the classification accuracy and time-consuming holistically, linear SVM with relative more voxels as features and RBF SVM with small set of voxels (after PCA) could achieve the better accuracy and cost shorter time. The present work provides the first empirical result of linear and RBF SVM in classification of fMRI data, combined with voxel selection methods. Based on the findings, if only classification accuracy was concerned, RBF SVM with appropriate small voxels and linear SVM with relative more voxels were two suggested solutions; if users concerned more about the computational time, RBF SVM with relative small set of voxels when part of the principal components were kept as features was a better choice.

  2. Mechanisms and Neural Basis of Object and Pattern Recognition: A Study with Chess Experts

    Science.gov (United States)

    Bilalic, Merim; Langner, Robert; Erb, Michael; Grodd, Wolfgang

    2010-01-01

    Comparing experts with novices offers unique insights into the functioning of cognition, based on the maximization of individual differences. Here we used this expertise approach to disentangle the mechanisms and neural basis behind two processes that contribute to everyday expertise: object and pattern recognition. We compared chess experts and…

  3. A Case Study on Coloured Petri Nets in Object-oriented Analysis and Design

    DEFF Research Database (Denmark)

    Barros, Joao Paulo; Jørgensen, Jens Bæk

    2005-01-01

    In this paper, we first demonstrate how a coloured Petri nets (CPN) model can be used to capture requirements for a considered example system, an elevator controller. Then, we show how this requirements-level CPN model is transformed into a design-level object-oriented CPN model, which...

  4. Middle School Students' Reasoning about 3-Dimensional Objects: A Case Study

    Science.gov (United States)

    Okumus, Samet

    2016-01-01

    According to the National Council of Teacher of Mathematics (NCTM) (2000), K-12 students should be given an opportunity to develop their spatial reasoning abilities. One of the topics that may allow students to develop their spatial skills is forming 3-dimensional objects using spinning and extrusion methods. Also, extrusion and spinning methods…

  5. Terrestrial scanning or digital images in inventory of monumental objects? - case study

    Science.gov (United States)

    Markiewicz, J. S.; Zawieska, D.

    2014-06-01

    Cultural heritage is the evidence of the past; monumental objects create the important part of the cultural heritage. Selection of a method to be applied depends on many factors, which include: the objectives of inventory, the object's volume, sumptuousness of architectural design, accessibility to the object, required terms and accuracy of works. The paper presents research and experimental works, which have been performed in the course of development of architectural documentation of elements of the external facades and interiors of the Wilanów Palace Museum in Warszawa. Point clouds, acquired from terrestrial laser scanning (Z+F 5003h) and digital images taken with Nikon D3X and Hasselblad H4D cameras were used. Advantages and disadvantages of utilisation of these technologies of measurements have been analysed with consideration of the influence of the structure and reflectance of investigated monumental surfaces on the quality of generation of photogrammetric products. The geometric quality of surfaces obtained from terrestrial laser scanning data and from point clouds resulting from digital images, have been compared.

  6. Comparative study of popular objective functions for damping power system oscillations in multimachine system.

    Science.gov (United States)

    Islam, Naz Niamul; Hannan, M A; Shareef, Hussain; Mohamed, Azah; Salam, M A

    2014-01-01

    Power oscillation damping controller is designed in linearized model with heuristic optimization techniques. Selection of the objective function is very crucial for damping controller design by optimization algorithms. In this research, comparative analysis has been carried out to evaluate the effectiveness of popular objective functions used in power system oscillation damping. Two-stage lead-lag damping controller by means of power system stabilizers is optimized using differential search algorithm for different objective functions. Linearized model simulations are performed to compare the dominant mode's performance and then the nonlinear model is continued to evaluate the damping performance over power system oscillations. All the simulations are conducted in two-area four-machine power system to bring a detailed analysis. Investigated results proved that multiobjective D-shaped function is an effective objective function in terms of moving unstable and lightly damped electromechanical modes into stable region. Thus, D-shape function ultimately improves overall system damping and concurrently enhances power system reliability.

  7. QUALITY OF NURSING DOCUMENTATION AND NURSE’S OBJECTIVE WORKLOAD BASED ON TIME AND MOTION STUDY (TMS

    Directory of Open Access Journals (Sweden)

    Mira Amelynda Prakosa

    2017-02-01

    Full Text Available Introduction. The quality of documentation can decrease because of bad admission filling of documentation. Workload is one of the factor that can influence admission filling of documentation. This study was aimed to analyze the correlation between nurse’s objective workload and the quality of nursing documentation in RSU Haji. Method. The design of this study was descriptive correlation with cross-sectional approach. The population on this study was the nurse that works in Marwah 3 and 4 inpatient care in RSU Haji Surabaya. The number of the sample was 14 respondents were selected by simple random sampling. The independent variable was nurse’s objective workload and the dependent variable was quality of nursing documentation. The data were analyzed by using regression logistic. Result. Nurse’s objective workload in RSU Haji was 72%. There was no correlational between nurse’s objective workload with the completeness of nursing documentation (P= 0,999, also nurse’s objective workload with accurate of nursing documentation (P= 0,999. Discussion. This study concluded that nurse’s objective workload was low and quality of nursing documentation was accurate enough and complete enough. Next researcher should provide precise operational so the factors that affected the quality of documentation can be reached and the workload of the nurses in RSU Haji become ideal. Keyword:  nurses, quality of nursing documentation, objective workload

  8. Mapping objects through a data motor NoSQL case study: framework for web applications development

    Directory of Open Access Journals (Sweden)

    Roger Calderón-Moreno

    2016-01-01

    Full Text Available This article emerged as an academic initiative in which it is observed that the areas of knowledge in software develop- ment under the paradigm of Object-oriented programming (OOP is confronted by a model data storage relational raising two scenarios different developers try to mitigate through conversions between types or using intermediate tools such as mapping relational objects that bring certain advantages and disadvantages, and therefore, was raised within the project the possibility of using a storage engine type non-relational or NoSQL.With the design and development of the framework for generating Web applications, the user can define objects to consider including in the application, which will be stored in MongoDB engine, which arranges the data in the form of documents. The dynamic structure of these documents can be used in many projects, including many who traditionally would work on relational databases.Aiming to socialize and evaluate the work done, some instruments were designed to collect information from users with experience in the field of databases and software development. As a result highlights that software developers have clear concepts of object persistence through object-relational mapping (ORM, that learning these techniques software development through implementing own code or using APIs have a high degree of complexity and mostly (60% they are aware that these implementations generate low performance in applications. In addition, the opening of these highlights to choose alternative to organize and store information, different to the relational approach used for several years.

  9. Task and spatial frequency modulations of object processing: an EEG study.

    Directory of Open Access Journals (Sweden)

    Matt Craddock

    Full Text Available Visual object processing may follow a coarse-to-fine sequence imposed by fast processing of low spatial frequencies (LSF and slow processing of high spatial frequencies (HSF. Objects can be categorized at varying levels of specificity: the superordinate (e.g. animal, the basic (e.g. dog, or the subordinate (e.g. Border Collie. We tested whether superordinate and more specific categorization depend on different spatial frequency ranges, and whether any such dependencies might be revealed by or influence signals recorded using EEG. We used event-related potentials (ERPs and time-frequency (TF analysis to examine the time course of object processing while participants performed either a grammatical gender-classification task (which generally forces basic-level categorization or a living/non-living judgement (superordinate categorization on everyday, real-life objects. Objects were filtered to contain only HSF or LSF. We found a greater positivity and greater negativity for HSF than for LSF pictures in the P1 and N1 respectively, but no effects of task on either component. A later, fronto-central negativity (N350 was more negative in the gender-classification task than the superordinate categorization task, which may indicate that this component relates to semantic or syntactic processing. We found no significant effects of task or spatial frequency on evoked or total gamma band responses. Our results demonstrate early differences in processing of HSF and LSF content that were not modulated by categorization task, with later responses reflecting such higher-level cognitive factors.

  10. Task and spatial frequency modulations of object processing: an EEG study.

    Science.gov (United States)

    Craddock, Matt; Martinovic, Jasna; Müller, Matthias M

    2013-01-01

    Visual object processing may follow a coarse-to-fine sequence imposed by fast processing of low spatial frequencies (LSF) and slow processing of high spatial frequencies (HSF). Objects can be categorized at varying levels of specificity: the superordinate (e.g. animal), the basic (e.g. dog), or the subordinate (e.g. Border Collie). We tested whether superordinate and more specific categorization depend on different spatial frequency ranges, and whether any such dependencies might be revealed by or influence signals recorded using EEG. We used event-related potentials (ERPs) and time-frequency (TF) analysis to examine the time course of object processing while participants performed either a grammatical gender-classification task (which generally forces basic-level categorization) or a living/non-living judgement (superordinate categorization) on everyday, real-life objects. Objects were filtered to contain only HSF or LSF. We found a greater positivity and greater negativity for HSF than for LSF pictures in the P1 and N1 respectively, but no effects of task on either component. A later, fronto-central negativity (N350) was more negative in the gender-classification task than the superordinate categorization task, which may indicate that this component relates to semantic or syntactic processing. We found no significant effects of task or spatial frequency on evoked or total gamma band responses. Our results demonstrate early differences in processing of HSF and LSF content that were not modulated by categorization task, with later responses reflecting such higher-level cognitive factors.

  11. An objective assessment of toddlers' physical activity and sedentary levels: a cross-sectional study.

    Science.gov (United States)

    Vanderloo, Leigh M; Tucker, Patricia

    2015-09-26

    Little evidence exists on the physical activity and sedentary time of Canadian toddlers; this study objectively measured such behaviors and compared participants' activity levels to national guidelines. Levels of screen-viewing among toddlers were also explored. Forty toddlers (mean age = 25.7 months) wore Actical accelerometers for seven consecutive days (15 s epoch). Parents/guardians completed a wear-time log and a demographic and screen-viewing questionnaire. Descriptive analyses were used to determine participants' levels of physical activity and sedentary time, to identify whether toddlers were meeting physical activity/sedentary guidelines, and to explore demographic variables. T-tests were used to assess whether toddlers' activity levels differed based on cut-points applied and various demographic and screen-related variables. Regression analyses were conducted to examine associations between toddlers' sedentary time and screen-viewing levels. Toddlers engaged in 37.27 (SD = 3.79) to 49.40 (SD = 3.29) mins/hr of sedentary time, 9.79 (SD = 2.90) to 18.78 (SD = 3.22) mins/hr of light-intensity physical activity (LPA), 0.82 (SD = 0.72) to 3.95 (SD = 1.93) mins/hr of moderate- to vigorous-intensity physical activity (MVPA), and 10.60 (SD =3.29) to 22.73 (SD = 3.97) mins/hr of total physical activity (TPA), based on the Trost et al. and the Canadian Health Measures Survey (CHMS) cut-points respectively; these rates were significantly different (p physical activity guidelines. No statistically significant differences in sedentary time or physical activity (all intensities) based on sex were reported (p sedentary behavior guidelines on weekdays and weekend days, respectively. The implications of this work suggest that a greater understanding of toddlers' activity patterns is needed; additional mechanisms of promoting active behaviors among this group should be explored.

  12. Feasibility study for objective oriented design of system thermal hydraulic analysis program

    International Nuclear Information System (INIS)

    Chung, Bub Dong; Jeong, Jae Jun; Hwang, Moon Kyu

    2008-01-01

    The system safety analysis code, such as RELAP5, TRAC, CATHARE etc. have been developed based on Fortran language during the past few decades. Refactoring of conventional codes has been also performed to improve code readability and maintenance. However the programming paradigm in software technology has been changed to use objects oriented programming (OOP), which is based on several techniques, including encapsulation, modularity, polymorphism, and inheritance. In this work, objective oriented program for system safety analysis code has been tried utilizing modernized C language. The analysis, design, implementation and verification steps for OOP system code development are described with some implementation examples. The system code SYSTF based on three-fluid thermal hydraulic solver has been developed by OOP design. The verifications of feasibility are performed with simple fundamental problems and plant models. (author)

  13. GPR Imaging for Deeply Buried Objects: A Comparative Study Based on FDTD Models and Field Experiments

    Science.gov (United States)

    Tilley, roger; Dowla, Farid; Nekoogar, Faranak; Sadjadpour, Hamid

    2012-01-01

    Conventional use of Ground Penetrating Radar (GPR) is hampered by variations in background environmental conditions, such as water content in soil, resulting in poor repeatability of results over long periods of time when the radar pulse characteristics are kept the same. Target objects types might include voids, tunnels, unexploded ordinance, etc. The long-term objective of this work is to develop methods that would extend the use of GPR under various environmental and soil conditions provided an optimal set of radar parameters (such as frequency, bandwidth, and sensor configuration) are adaptively employed based on the ground conditions. Towards that objective, developing Finite Difference Time Domain (FDTD) GPR models, verified by experimental results, would allow us to develop analytical and experimental techniques to control radar parameters to obtain consistent GPR images with changing ground conditions. Reported here is an attempt at developing 20 and 3D FDTD models of buried targets verified by two different radar systems capable of operating over different soil conditions. Experimental radar data employed were from a custom designed high-frequency (200 MHz) multi-static sensor platform capable of producing 3-D images, and longer wavelength (25 MHz) COTS radar (Pulse EKKO 100) capable of producing 2-D images. Our results indicate different types of radar can produce consistent images.

  14. [Comparison study on subjective and objective measurements of the accommodative convergence to accommodation ratio].

    Science.gov (United States)

    Xu, Jing-jing; Xu, Dan; Huang, Tao; Jiang, Jian; Lü, Fan

    2012-05-01

    To detect the accommodative convergence to accommodation (AC/A) ratios measured respectively by objective and subjective methods. The differences and its relative factors were explored. Forty young volunteers were measured by eye tracker to get the amount of convergence when fixating at the target at 100 cm, 50 cm, 33 cm and 25 cm and were measured by infrared auto-refractor to get corresponding accommodative responses. AC/A ratio based on these two measurements were compared with the calculated and the gradient AC/A ratio from Von Graefe tests. Mean value of stimulated AC/A ratio measured by eye tracker was higher than the calculated and gradient AC/A ratio by Von Graefe method (P = 0.003, 0.001). There are statistic correlation (r = 0.871, P = 0.000) and difference (P = 0.000) between stimulated AC/A ratio and response AC/A ratios both measured by eye tracker, and the difference trends to be greater with the higher AC/A ratio. The objective AC/A ratio is usually higher than the clinical subjective measurement because of more proximal effect. The response AC/A ratio measured objectively may reveal realistically the mutual effect and relationship between accommodation and convergence and it seems to be more credible to be the monitor parameter on progression of myopia in clinics.

  15. A study of objective functions for organs with parallel and serial architecture

    International Nuclear Information System (INIS)

    Stavrev, P.V.; Stavreva, N.A.; Round, W.H.

    1997-01-01

    An objective function analysis when target volumes are deliberately enlarged to account for tumour mobility and consecutive uncertainty in the tumour position in external beam radiotherapy has been carried out. The dose distribution inside the tumour is assumed to have logarithmic dependence on the tumour cell density which assures an iso-local tumour control probability. The normal tissue immediately surrounding the tumour is irradiated homogeneously at a dose level equal to the dose D(R)) delivered at the edge of the tumour The normal tissue in the high dose field is modelled as being organized in identical functional subunits (FSUs) composed of a relatively large number of cells. Two types of organs - having serial and parallel architecture are considered. Implicit averaging over intrapatient normal tissue radiosensitivity variations is done. A function describing the normal tissue survival probability S 0 is constructed. The objective function is given as a product of the total tumour control probability (TCP) and the normal tissue survival probability S 0 . The values of the dose D(R)) which result in a maximum of the objective function are obtained for different combinations of tumour and normal tissue parameters, such as tumour and normal tissue radiosensitivities, number of cells constituting a normal tissue functional unit, total number of normal cells under high dose (D(R)) exposure and functional reserve for organs having parallel architecture. The corresponding TCP and S 0 values are computed and discussed. (authors)

  16. An electrophysiological study of the object-based correspondence effect: is the effect triggered by an intended grasping action?

    Science.gov (United States)

    Lien, Mei-Ching; Jardin, Elliott; Proctor, Robert W

    2013-11-01

    We examined Goslin, Dixon, Fischer, Cangelosi, and Ellis's (Psychological Science 23:152-157, 2012) claim that the object-based correspondence effect (i.e., faster keypress responses when the orientation of an object's graspable part corresponds with the response location than when it does not) is the result of object-based attention (vision-action binding). In Experiment 1, participants determined the category of a centrally located object (kitchen utensil vs. tool), as in Goslin et al.'s study. The handle orientation (left vs. right) did or did not correspond with the response location (left vs. right). We found no correspondence effect on the response times (RTs) for either category. The effect was also not evident in the P1 and N1 components of the event-related potentials, which are thought to reflect the allocation of early visual attention. This finding was replicated in Experiment 2 for centrally located objects, even when the object was presented 45 times (33 more times than in Exp. 1). Critically, the correspondence effects on RTs, P1s, and N1s emerged only when the object was presented peripherally, so that the object handle was clearly located to the left or right of fixation. Experiment 3 provided further evidence that the effect was observed only for the base-centered objects, in which the handle was clearly positioned to the left or right of center. These findings contradict those of Goslin et al. and provide no evidence that an intended grasping action modulates visual attention. Instead, the findings support the spatial-coding account of the object-based correspondence effect.

  17. Longitudinal study of the feasibility of using ecological momentary assessment to study teacher stress: Objective and self-reported measures.

    Science.gov (United States)

    McIntyre, Teresa M; McIntyre, Scott E; Barr, Christopher D; Woodward, Phillip S; Francis, David J; Durand, Angelia C; Mehta, Paras; Kamarck, Thomas W

    2016-10-01

    There is a lack of comprehensive research on Ecological Momentary Assessment (EMA) feasibility to study occupational stress, especially its long-term sustainability. EMA application in education contexts has also been sparse. This study investigated the feasibility of using EMA to study teacher stress over 2 years using both objective compliance data and a self-reported feasibility survey. It also examined the influence of individual and school factors on EMA feasibility. Participants were 202 sixth through eighth grade teachers from 22 urban middle schools in the southern United States. EMA was implemented via an iPod-based Teacher Stress Diary (TSD). Teachers recorded demands, stress responses, and resources during 12 days (6 waves) over 2 years. Feasibility was assessed via compliance data generated by the TSD (e.g., entry completion) and an EMA Feasibility Survey of self-reported user-friendliness and EMA interference. The results showed high compliance regarding entry and item completion, and completion time, which was sustained over time. User-friendliness was appraised as very high and EMA interference as low. Initial difficulties regarding timing and length of assessments were addressed via EMA method refinement, resulting in improved feasibility. Teachers' ethnicity, age, marital status, grade/course taught, class size, class load, and daily workload impacted feasibility. The results supported the feasibility of using EMA to study work stress longitudinally and the value of continued feasibility monitoring. They also support EMA use to study teacher stress and inform EMA implementation in schools. Some teacher and school factors need to be taken into consideration when deciding on EMA implementation in education contexts. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  18. Longitudinal development of object permanence in mentally retarded children: an exploratory study.

    Science.gov (United States)

    Wohlhueter, M J; Sindberg, R M

    1975-03-01

    Monthly testing on a series of Piaget object tasks was carried out on 1- to 6-year-old profoundly, severly, and moderately retarded children. Forty nine subjects were followed for 1 to 1.5 years or to criterion; 18 subjects were followed for shorter periods. Three general patterns occurred among the noncriterion subjects with approximately equeal frequency: (a) little or no change, (b) marked variability, and (c) relatively steady upward change from month to month. Criterion and upward subjects skipped certain substages about one-half of the time. Degree of retardation, CA, and diagnostic concomitants of these observations were discussed.

  19. Cross-sectional study of object permanence in domestic puppies (Canis familiaris).

    Science.gov (United States)

    Gagnon, S; Doré, F Y

    1994-09-01

    Visual accommodation and object permanence tests were administered to 70 puppies (Canis familiaris), aged 4 weeks to 9 months. The results showed that understanding of visible displacement problems emerged at the 5th weeks and developed rapidly until the 8th week. Although the search behaviors of older puppies were more flexible, no further significant development was observed between 8 weeks and 9 months. The results on invisible displacement tests suggest that understanding of invisible displacement problems appears around the 1st year in dogs' development.

  20. FLARE STARS—A FAVORABLE OBJECT FOR STUDYING MECHANISMS OF NONTHERMAL ASTROPHYSICAL PHENOMENA

    Energy Technology Data Exchange (ETDEWEB)

    Oks, E. [Physics Department, 206 Allison Lab., Auburn University, Auburn, AL 36849 (United States); Gershberg, R. E. [Crimean Astrophysical Observatory, Nauchny, Bakhchisaray region, Crimea, 298409 (Russian Federation)

    2016-03-01

    We present a spectroscopic method for diagnosing a low-frequency electrostatic plasma turbulence (LEPT) in plasmas of flare stars. This method had been previously developed by one of us and successfully applied to diagnosing the LEPT in solar flares. In distinction to our previous applications of the method, here we use the latest advances in the theory of the Stark broadening of hydrogen spectral lines. By analyzing observed emission Balmer lines, we show that it is very likely that the LEPT was developed in several flares of AD Leo, as well as in one flare of EV Lac. We found the LEPT (though of different field strengths) both in the explosive/impulsive phase and at the phase of the maximum, as well as at the gradual phase of the stellar flares. While for solar flares our method allows diagnosing the LEPT only in the most powerful flares, for the flare stars it seems that the method allows revealing the LEPT practically in every flare. It should be important to obtain new and better spectrograms of stellar flares, allowing their analysis by the method outlined in the present paper. This can be the most favorable way to the detailed understanding of the nature of nonthermal astrophysical phenomena.

  1. Object-related vs. narcissistic depression: a theoretical and clinical study.

    Science.gov (United States)

    Glazer, M W

    1979-01-01

    This paper has focused on the sense of helplessness as an essential component of a depressive reaction. By inference, a sense of mastery and ability to achieve goals seems essential for a sense of well-being. Both patients presented here revealed infantile fantasies that hampered their exercising this mastery, and the path to well-being was the analysis of these fantasies. The treatment plans differed, though, in the locus of the fantasies. In an object-related depression such as Mr. Janson's, the fantasy involved the inhbition of functioning--that is, the inability to express aggression--and the treatment aimed at removing the inhibition. In a narcissistic depression such as Miss Gaynor's, the helplessness was not due to inhibited functioning per se. Rather, her goals were unrealistic, unattainable, and based on unconscious fantasies. Here the aim of treatment was the development of more reality-adapted and attainable objectives and the concommitant internalization of a more realistic sense of her own worth. Thus the common denominator in both depressive reactions was a sense of helplessness, and the path toward increased self-esteem was by way of the development of a sense of mastery and competence.

  2. Technical study on semi-object emulation of structural statics problem

    International Nuclear Information System (INIS)

    Mo Jun; Shi Pingan; Liu Xingfu; Liu Zhiyong; Fu Chunyu

    2002-01-01

    Structural strength analysis depends mainly on finite element method and experiments. For complex structural system, a rather large error can be caused by some uncertain factors, such as load distributions, boundary conditions and constitutive relations in numerical analysis. At the same time, owing to the limitation of measuring and testing techniques, the strength and stiffness of key components can not be estimated by using the limited test data. To simulate stresses accurately under complex static environment, improve man-machine interactive system, and make the best use of fore- and post-processing function in graphic data processing, the authors combine numerical analysis with experimental technique and have developed the semi-object emulation technique to analyze the nonlinear problem of structure statics. The modern optical measuring techniques and image processing techniques are firstly used for the method to acquire displacement data of the vessel surface, and the data are used for the boundary condition to determine the geometrical size of disfigurement in the wall of vessel and the stress level. The experimental verification of a given test model show that these adverse problem can be solved by using semi-object emulation technology

  3. Implementation of object-oriented programming in study of electrical race car

    Science.gov (United States)

    Nowak, M.; Baier, M.

    2016-08-01

    The paper covers issue of conducting advanced research of electrical race car participating in international competition called Sileverline Corporate Challenge. Process of designing race cars in Silesian Greenpower team is aided by a professional engine test stand built particularly in purpose of this research. Phase of testing and simulation is an important part of the implementation of new technologies. Properly developed solutions and test procedures are able to significantly shorten development time and reduce design costs. Testing process must be controlled by a modular and flexible application, easy to modify and ensuring safety. This paper describes the concept of object-oriented programming in LabVIEW and exemplary architecture of object-oriented control application designed to control engine test stand of the electrical race car. Eventually, the task of application will be to steer the electromagnetic brake and the engine load torque to perform according to data from the actual race track. During the designing process of the car, minimizing energy losses and maximizing powertrain efficiency are the main aspects taken into consideration. One of the crucial issues to accomplish these goals is to maintain optimal performance of the motor by applying effective cooling. The paper covers the research verifying the effectiveness of the cooling system.

  4. INDEXES OF OBESITY AND COMPARISONS WITH PREVIOUS NATIONAL SURVEY DATA IN 9-YEAR-OLD AND 10-YEAR-OLD BLACK-AND-WHITE GIRLS - THE NATIONAL HEART, LUNG, AND BLOOD INSTITUTE GROWTH AND HEALTH STUDY

    NARCIS (Netherlands)

    CAMPAIGNE, BN; MORRISON, JA; SCHUMANN, BC; FALKNER, F; LAKATOS, E; SPRECHER, D; SCHREIBER, GB

    Objective: To (I) describe anthropometric and body-size measurements in the National Heart, Lung, and Blood Institute Growth and Health Study (NGHS) population at baseline and (2) examine potential secular trends in the prevalence of obesity in young black and white girls by comparing NGHS baseline

  5. Earlier and greater hand pre-shaping in the elderly: a study based on kinematic analysis of reaching movements to grasp objects.

    Science.gov (United States)

    Tamaru, Yoshiki; Naito, Yasuo; Nishikawa, Takashi

    2017-11-01

    Elderly people are less able to manipulate objects skilfully than young adults. Although previous studies have examined age-related deterioration of hand movements with a focus on the phase after grasping objects, the changes in the reaching phase have not been studied thus far. We aimed to examine whether changes in hand shape patterns during the reaching phase of grasping movements differ between young adults and the elderly. Ten healthy elderly adults and 10 healthy young adults were examined using the Simple Test for Evaluating Hand Functions and kinetic analysis of hand pre-shaping reach-to-grasp tasks. The results were then compared between the two groups. For kinetic analysis, we measured the time of peak tangential velocity of the wrist and the inter-fingertip distance (the distance between the tips of the thumb and index finger) at different time points. The results showed that the elderly group's performance on the Simple Test for Evaluating Hand Functions was significantly lower than that of the young adult group, irrespective of whether the dominant or non-dominant hand was used, indicating deterioration of hand movement in the elderly. The peak tangential velocity of the wrist in either hand appeared significantly earlier in the elderly group than in the young adult group. The elderly group also showed larger inter-fingertip distances with arch-like fingertip trajectories compared to the young adult group for all object sizes. To perform accurate prehension, elderly people have an earlier peak tangential velocity point than young adults. This allows for a longer adjustment time for reaching and grasping movements and for reducing errors in object prehension by opening the hand and fingers wider. Elderly individuals gradually modify their strategy based on previous successes and failures during daily living to compensate for their decline in dexterity and operational capabilities. © 2017 Japanese Psychogeriatric Society.

  6. X-ray microscopy study of track membranes and biological objects

    International Nuclear Information System (INIS)

    Artioukov, I.A.; Levashov, V.E.; Struk, I.I.; Vinogradov, A.V.; Asadchikov, V.E.; Mchedlishvili, B.V.; Postnov, A.A.; Vilensky, A.I.; Zagorsky, D.L.; Gulimova, V.I.; Saveliev, S.V.; Kurohtin, A.N.; Popov, A.V.

    2000-01-01

    The development of two types of X-ray microscopy applying to the organic objects investigation (biological samples and polymer matrix) is reported. Polymer track membranes were investigated using Schwarzchild X-ray microscope with 20 nm wavelength. Pore diameters down to 0.2 μm were clearly imaged. Contact X-ray microscopy at 0.229 nm wavelength was used to obtain clear images of inner structure of native biological samples. High contrast together with the high resolution (about 2-3 μm) allowed us to use this method for quantitative analysis of demineralization process taking place in the skeleton of amphibious after several weeks of weightlessness on biosputnik board

  7. Designing pilot projects as boundary objects a Brazilian case study in the promotion of sustainable design

    CERN Document Server

    Zurlo, Francesco

    2016-01-01

    This book describes a collaborative Design Pilot Project held in Brazil (called MODU.Lares) involving micro and small enterprises and other actors in the furniture sector. The experience was based on an action research method and evaluated by using a tool, in order to assess the value of pilot project as a boundary object capable of fostering innovation and sustainability. The impact of the Design Pilot Project in triggering change in a fragmented local system with a poor environmental and social record, as well as management and innovation issues, were assessed with the help of the same tool, taking into account environmental, technological, economic, sociocultural, and organizational indicators. The collaborative network established was chiefly based on four elements: prototypes, meetings, exhibitions and the Pilot Project (as an overall process). The results indeed demonstrate that a Design Pilot Project can be a valid instrument for establishing a collaborative environment that promotes sustainability an...

  8. Bi-objective Optimization of the Water Distribution Networks (Case Study: Sahand City

    Directory of Open Access Journals (Sweden)

    Ali Nikjoofar

    2012-12-01

    Full Text Available To design an urban water network in addition to minimizing the cost, improving the water pressure is very important. Then in this paper a bi-objective optimization model for the new city of Sahand in Northwestern Iran is developed.  Due to its non-linearity and the huge number of variables, the genetic algorithm has been utilized to solve it. Several Pareto solutions have been obtained and then based on the game theory approach (the area monotonic solution, the most efficient point was provided. The solution is simulated by the WaterGems software and the elements of the network are designed. This optimum solution shows a decrease of 13% in total cost in addition to the improved water pressure.

  9. Technical study on semi-object emulation of structural statics problem

    CERN Document Server

    MoJun; LiuXingFu; LiuZhiYong; Shi Pin Gan

    2002-01-01

    Structural strength analysis depends mainly on finite element method and experiments. For complex structural system, a rather large error can be caused by some uncertain factors, such as load distributions, boundary conditions and constitutive relations in numerical analysis. At the same time, owing to the limitation of measuring and testing techniques, the strength and stiffness of key components can not be estimated by using the limited test data. To simulate stresses accurately under complex static environment, improve man-machine interactive system, and make the best use of fore- and post-processing function in graphic data processing, the combine numerical analysis with experimental technique and have developed the semi-object emulation technique to analyze the nonlinear problem of structure statics. The modern optical measuring techniques and image processing techniques are firstly used for the method to acquire displacement data of the vessel surface, and the data are used for the boundary condition to...

  10. Mental rotation versus invariant features in object perception from different viewpoints: an fMRI study.

    Science.gov (United States)

    Vanrie, Jan; Béatse, Erik; Wagemans, Johan; Sunaert, Stefan; Van Hecke, Paul

    2002-01-01

    It has been proposed that object perception can proceed through different routes, which can be situated on a continuum ranging from complete viewpoint-dependency to complete viewpoint-independency, depending on the objects and the task at hand. Although these different routes have been extensively demonstrated on the behavioral level, the corresponding distinction in the underlying neural substrate has not received the same attention. Our goal was to disentangle, on the behavioral and the neurofunctional level, a process associated with extreme viewpoint-dependency, i.e. mental rotation, and a process associated with extreme viewpoint-independency, i.e. the use of viewpoint-invariant, diagnostic features. Two sets of 3-D block figures were created that either differed in handedness (original versus mirrored) or in the angles joining the block components (orthogonal versus skewed). Behavioral measures on a same-different judgment task were predicted to be dependent on viewpoint in the rotation condition (same versus mirrored), but not in the invariance condition (same angles versus different angles). Six subjects participated in an fMRI experiment while presented with both conditions in alternating blocks. Both reaction times and accuracy confirmed the predicted dissociation between the two conditions. Neurofunctional results indicate that all cortical areas activated in the invariance condition were also activated in the rotation condition. Parietal areas were more activated than occipito-temporal areas in the rotation condition, while this pattern was reversed in the invariance condition. Furthermore, some areas were activated uniquely by the rotation condition, probably reflecting the additional processes apparent in the behavioral response patterns.

  11. A Case Study: Optimal Stage Gauge NetworkUsing Multi Objective Genetic Algorithm

    Science.gov (United States)

    Joo, H. J.; Han, D.; Jung, J.; Kim, H. S.

    2017-12-01

    Recently, the possibility of occurrence of localized strong heavy rainfall due to climate change is increasing and flood damage is also increasing trend in Korea. Therefore we need more precise hydrologic analysis for preparing alternatives or measures for flood reduction by considering climate conditions which we have difficulty in the prediction. To do this, obtaining reliable hydrologic data, for an example, stage data, is very important. However, the existing stage gauge stations are scattered around the country, making it difficult to maintain them in a stable manner, and subsequently hard to acquire the hydrologic data that could be used for reflecting the localized hydrologic characteristics. In order to overcome such restrictions, this paper not only aims to establish a plan to acquire the water stage data in a constant and proper manner by using limited manpower and costs, but also establishes the fundamental technology for acquiring the water level observation data or the stage data. For that, this paper identifies the current status of the stage gauge stations installed in the Chung-Ju dam in Han river, Korea and extract the factors related to the division and characteristics of basins. Then, the obtained factors are used to develop the representative unit hydrograph that shows the characteristics of flow. After that, the data are converted into the probability density function and the stations at individual basins are selected by using the entropy theory. In last step, we establish the optimized stage gauge network by the location of the stage station and grade using the Multi Objective Genetic Algorithm(MOGA) technique that takes into account for the combinations of the number of the stations. It is expected that this paper can help establish an optimal observational network of stage guages as it can be applied usefully not only for protecting against floods in a stable manner, but also for acquiring the hydrologic data in an efficient manner. Keywords

  12. Elegant objects

    CERN Document Server

    Bugayenko, Yegor

    2017-01-01

    There are 23 practical recommendations for object-oriented programmers. Most of them are completely against everything you've read in other books. For example, static methods, NULL references, getters, setters, and mutable classes are called evil. Compound variable names, validators, private static literals, configurable objects, inheritance, annotations, MVC, dependency injection containers, reflection, ORM and even algorithms are our enemies.

  13. Objective lens

    Science.gov (United States)

    Olczak, Eugene G. (Inventor)

    2011-01-01

    An objective lens and a method for using same. The objective lens has a first end, a second end, and a plurality of optical elements. The optical elements are positioned between the first end and the second end and are at least substantially symmetric about a plane centered between the first end and the second end.

  14. Wealth, justice and freedom: Objective and subjective measures predicting poor mental health in a study across eight countries.

    Science.gov (United States)

    Scholten, Saskia; Velten, Julia; Neher, Torsten; Margraf, Jürgen

    2017-12-01

    Macro-level factors (MF) such as wealth, justice and freedom measured with objective country-level indicators (objective MF), for instance the Gross Domestic Product (GDP), have been investigated in relation to health and well-being, but rarely in connection with depression, anxiety and stress subsumed as poor mental health. Also, a combination of different objective MF and of how individuals perceive those MF (subjective MF) has not been taken into consideration. In the present study, we combined subjective and objective measures of wealth, justice and freedom and examined their relationship with poor mental health. Population-based interviews were conducted in France, Germany, Poland, Russia, Spain, Sweden, U.K. and U.S.A. (n ≈ 1000 per country). GDP, GINI coefficient, Justice Index and Freedom Index were used as objective MF, whereas subjective MF were perceived wealth, justice and freedom measured at the individual level. Poor mental health was assessed as a combination of symptoms of depression, anxiety and stress. In a random-intercept-model, GINI coefficient and Freedom Index were significant positive country-level, and perceived wealth, justice, and freedom significant negative individual-level predictors of symptoms of poor mental health. Multiple subjective and objective MF should be combined to assess the macrosystem's relationship with poor mental health more precisely. The relationship between MF and poor mental health indicates that the macrosystem should be taken into account as relevant context for mental health problems, too.

  15. Data Quality Objectives For Selecting Waste Samples For Bench-Scale Reformer Treatability Studies

    International Nuclear Information System (INIS)

    Banning, D.L.

    2011-01-01

    This document describes the data quality objectives to select archived samples located at the 222-S Laboratory for Bench-Scale Reforming testing. The type, quantity, and quality of the data required to select the samples for Fluid Bed Steam Reformer testing are discussed. In order to maximize the efficiency and minimize the time to treat Hanford tank waste in the Waste Treatment and Immobilization Plant, additional treatment processes may be required. One of the potential treatment processes is the fluidized bed steam reformer. A determination of the adequacy of the fluidized bed steam reformer process to treat Hanford tank waste is required. The initial step in determining the adequacy of the fluidized bed steam reformer process is to select archived waste samples from the 222-S Laboratory that will be used in a bench scale tests. Analyses of the selected samples will be required to confirm the samples meet the shipping requirements and for comparison to the bench scale reformer (BSR) test sample selection requirements.

  16. Objective Structured Assessment of Technical Skills (OSATS) evaluation of hysteroscopy training: a prospective study.

    Science.gov (United States)

    Alici, Ferizan; Buerkle, Bernd; Tempfer, Clemens B

    2014-07-01

    To describe the performance curve of hysteroscopy-naïve probands repeatedly working through a surgery algorithm on a hysteroscopy trainer. We prospectively recruited medical students to a 30min demonstration session teaching a standardized surgery algorithm. Subjects subsequently performed three training courses immediately after training (T1) and after 24h (T2) and 48h (T3). Skills were recorded with a 20-item Objective Structured Assessment of Technical Skills (OSATS) at T1, T2, and T3. The presence of a sustained OSATS score improvement from T1 to T3 was the primary outcome. Performance time (PT) and self assessment (SA) were secondary outcomes. Statistics were performed using paired T-test and multiple linear regression analysis. 92 subjects were included. OSATS scores significantly improved over time from T1 to T2 (15.21±1.95 vs. 16.02±2.06, respectively; ptraining courses on a hysteroscopy trainer. Serial hysteroscopy trainings may be helpful for teaching hysteroscopy skills. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  17. Conserving energy in smallholder agriculture. A multi-objective programming case-study of northwest India

    International Nuclear Information System (INIS)

    Thankappan, Samarthia; Midmore, Peter; Jenkins, Tim

    2006-01-01

    In semi-arid conditions in Northwest India, smallholder agriculture has made increasing use of subsidised mechanisation and energy inputs to reduce short-term risks. However, detrimental environmental consequences have occurred, not least a rapidly falling water table, and energy-intensive production is threatened by the prospect of increasing scarcity and expense of energy supplies, especially as urban demands are forecast to grow rapidly. This paper describes the energy flows through four subsystems of smallholder agricultural villages: the crop system; non-crop land uses; livestock systems; and households. It employs a multi-objective programming model to demonstrate choices available for maximands either of net solar energy capture or financial surpluses. Applied to three villages selected to represent major settlement types in the Saurashtra region of Gujarat, the results demonstrate that both energy conservation and financial performance can be improved. Although these results need qualifying because of the reductionist, linear character of the model used, they do provide important insights into the cultural role of mechanisation and the influence of traditional agricultural practices. They also underline the need for local energy conservation strategies as part of an overall approach to improved self-determination in progress towards rural sustainability. (author)

  18. Multi-objective optimisation with stochastic discrete-event simulation in retail banking: a case study

    Directory of Open Access Journals (Sweden)

    E Scholtz

    2012-12-01

    Full Text Available The cash management of an autoteller machine (ATM is a multi-objective optimisation problem which aims to maximise the service level provided to customers at minimum cost. This paper focus on improved cash management in a section of the South African retail banking industry, for which a decision support system (DSS was developed. This DSS integrates four Operations Research (OR methods: the vehicle routing problem (VRP, the continuous review policy for inventory management, the knapsack problem and stochastic, discrete-event simulation. The DSS was applied to an ATM network in the Eastern Cape, South Africa, to investigate 90 different scenarios. Results show that the application of a formal vehicle routing method consistently yields higher service levels at lower cost when compared to two other routing approaches, in conjunction with selected ATM reorder levels and a knapsack-based notes dispensing algorithm. It is concluded that the use of vehicle routing methods is especially beneficial when the bank has substantial control over transportation cost.

  19. Dust exposure and pneumoconiosis in a South African pottery. 1. Study objectives and dust exposure.

    Science.gov (United States)

    Rees, D; Cronje, R; du Toit, R S

    1992-07-01

    Dust exposure and pneumoconiosis were investigated in a South African pottery that manufactured wall tiles and bathroom fittings. This paper describes the objectives of the investigation and presents dust measurement data. x Ray diffraction showed that the clays used by the pottery had a high quartz content (range 58%-23%, mean 38%). Exposure to respirable dust was measured for 43 workers and was highest (6.6 mg/m3) in a bathroom fitting fettler. Quartz concentrations in excess of 0.1 mg/m3 were found in all sections of the manufacturing process from slip production to biscuit firing and sorting. The proportion of quartz in the respirable dust of these sections was 24% to 33%. This is higher than is usually reported in English potteries. Four hundred and six (80%) of the 509 workers employed at the pottery were potentially at risk of occupational lung disease. The finding of large numbers of pottery workers exposed to unacceptable dust concentrations is not surprising as poor dust control was found in all six wall tile and sanitary ware factories surveyed by the National Centre for Occupational Health between 1973 and 1989. Dust related occupational disease can be expected in potters for many years to come.

  20. Ethnic differences in objective and subjective skin irritation response: an international study.

    Science.gov (United States)

    Lee, E; Kim, S; Lee, J; Cho, S-A; Shin, K

    2014-08-01

    Due to global marketing in the cosmetics industry, it is important to assess ethnic population susceptibility when evaluating the safety of cosmetic products or chemicals. To investigate ethnic variations in skin irritation response to positive irritants. Clinical testing was performed in four countries on two ethnic groups - Asian and Caucasian. We performed patch tests on the subjects' back with 0.5% aqueous sodium lauryl sulfate (SLS) and 0.15% retinol prepared in 1,3-butylene glycol. Stinging tests were performed using 5% aqueous lactic acid and 0.001% (w/v) capsaicin prepared in 10% ethanol solution separately. The incidence of self-perceived skin sensitivity was similar in the two ethnic groups. However, the incidence of adverse skin reaction to cosmetics appeared significantly higher in Asian (33.0%) than in Caucasian subjects (11.3%). For standard positive irritants such as 0.5% aqueous SLS solution, Asian subjects showed significantly higher scores than Caucasian subjects. The incidence of positive reaction to the 0.15% retinol patch test tended to be higher in Asian than in Caucasian subjects. Our data also showed that neurosensitivity to 5% lactic acid and 0.001% capsaicin was higher in Asian than in Caucasian subjects. Although self-reported skin sensitivity does not appear to differ according to ethnicity, there are ethnic differences in objective and subjective skin irritation responses to several standard positive materials. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  1. Comparative Study of Evolutionary Multi-objective Optimization Algorithms for a Non-linear Greenhouse Climate Control Problem

    DEFF Research Database (Denmark)

    Ghoreishi, Newsha; Sørensen, Jan Corfixen; Jørgensen, Bo Nørregaard

    2015-01-01

    Non-trivial real world decision-making processes usually involve multiple parties having potentially conflicting interests over a set of issues. State-of-the-art multi-objective evolutionary algorithms (MOEA) are well known to solve this class of complex real-world problems. In this paper, we...... compare the performance of state-of-the-art multi-objective evolutionary algorithms to solve a non-linear multi-objective multi-issue optimisation problem found in Greenhouse climate control. The chosen algorithms in the study includes NSGAII, eNSGAII, eMOEA, PAES, PESAII and SPEAII. The performance...... of all aforementioned algorithms is assessed and compared using performance indicators to evaluate proximity, diversity and consistency. Our insights to this comparative study enhanced our understanding of MOEAs performance in order to solve a non-linear complex climate control problem. The empirical...

  2. The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods.

    NARCIS (Netherlands)

    Penninx, B.W.J.H.; Beekman, A.T.F.; Smit, J.H.; Zitman, F.G.; Nolen, W.A.; Spinhoven, P.; Cuijpers, P.; Jong, P.J. de; Marwijk, H.W.J. van; Assendelft, W.J.J.; Meer, K. van der; Verhaak, P.; Wensing, M.; Graaf, R. de; Hoogendijk, W.J.; Ormel, J.; Dyck, R. van

    2008-01-01

    The Netherlands Study of Depression and Anxiety (NESDA) is a multi-site naturalistic cohort study to: (1) describe the long-term course and consequences of depressive and anxiety disorders, and (2) to integrate biological and psychosocial research paradigms within an epidemiological approach in

  3. Numerical study of properties of many-dimensional soliton-type objects

    International Nuclear Information System (INIS)

    Makhankov, V.G.; Shvachka, A.B.

    1980-01-01

    A brief review of the dynamical properties of many-dimensional quasi-solitons studied by means of the computer simulation in the framework of the nonlinear classical field theory models is presented. It is shown that the types of soliton interactions are model independent for studied models

  4. Columnar modelling of nucleation burst evolution in the convective boundary layer – first results from a feasibility study Part IV: A compilation of previous observations for valuation of simulation results from a columnar modelling study

    Directory of Open Access Journals (Sweden)

    O. Hellmuth

    2006-01-01

    according to the parameterisation of the collision-controlled binary nucleation rate proposed by Weber et al. (1996, H2O vapour does not explicitly affect the particle formation. Since the H2SO4 concentration is overpredicted in the simulations presented in Paper III, the nucleation rates are too high compared to previous estimations. Therefore, the results are not directly comparable to measurements. Especially NPF events, where organics are suspected to play a key role, such as those observed at the boreal forest station in Hyytiälä (Southern Finland or at Hohenpeissenberg (mountain site in Southern Germany, can not be explained by employing simple sulphur/ammonia chemistry. However, some valuable hints regarding the role of CBL turbulence in NPF can be obtained. In the literature a number of observations on the link between turbulence and NPF can be found, whose burst patterns support a strong contribution of CBL turbulence to the NPF burst evolution simulated here. Observations, that do not correspond to the scenarios are discussed with respect to possible reasons for the differences between model and observation. The model simulations support some state-of-the-art hypotheses on the contribution of CBL turbulence to NPF. Considering the application of box models, the present study shows, that CBL turbulence, not explicitly considered in such models, can strongly affect the spatio-temporal NPF burst evolution. The columnar high-order model presented here is a helpful tool to elucidate gas-aerosol-turbulence interactions, especially the genesis of NPF bursts in the CBL. An advanced description of the cluster formation and condensation growth is required as well as a comprehensive verification/validation study using observed high-order moments. Further scenario simulations remain to be performed.

  5. Underwater Photogrammetry and Object Modeling: A Case Study of Xlendi Wreck in Malta

    Science.gov (United States)

    Drap, Pierre; Merad, Djamal; Hijazi, Bilal; Gaoua, Lamia; Nawaf, Mohamad Motasem; Saccone, Mauro; Chemisky, Bertrand; Seinturier, Julien; Sourisseau, Jean-Christophe; Gambin, Timmy; Castro, Filipe

    2015-01-01

    In this paper we present a photogrammetry-based approach for deep-sea underwater surveys conducted from a submarine and guided by knowledge-representation combined with a logical approach (ontology). Two major issues are discussed in this paper. The first concerns deep-sea surveys using photogrammetry from a submarine. Here the goal was to obtain a set of images that completely covered the selected site. Subsequently and based on these images, a low-resolution 3D model is obtained in real-time, followed by a very high-resolution model produced back in the laboratory. The second issue involves the extraction of known artefacts present on the site. This aspect of the research is based on an a priori representation of the knowledge involved using systematic reasoning. Two parallel processes were developed to represent the photogrammetric process used for surveying as well as for identifying archaeological artefacts visible on the sea floor. Mapping involved the use of the CIDOC-CRM system (International Committee for Documentation (CIDOC)—Conceptual Reference Model)—This is a system that has been previously utilised to in the heritage sector and is largely available to the established scientific community. The proposed theoretical representation is based on procedural attachment; moreover, a strong link is maintained between the ontological description of the modelled concepts and the Java programming language which permitted 3D structure estimation and modelling based on a set of oriented images. A very recently discovered shipwreck acted as a testing ground for this project; the Xelendi Phoenician shipwreck, found off the Maltese coast, is probably the oldest known shipwreck in the western Mediterranean. The approach presented in this paper was developed in the scope of the GROPLAN project (Généralisation du Relevé, avec Ontologies et Photogrammétrie, pour l'Archéologie Navale et Sous-marine). Financed by the French National Research Agency (ANR) for four

  6. Underwater Photogrammetry and Object Modeling: A Case Study of Xlendi Wreck in Malta.

    Science.gov (United States)

    Drap, Pierre; Merad, Djamal; Hijazi, Bilal; Gaoua, Lamia; Nawaf, Mohamad Motasem; Saccone, Mauro; Chemisky, Bertrand; Seinturier, Julien; Sourisseau, Jean-Christophe; Gambin, Timmy; Castro, Filipe

    2015-12-04

    In this paper we present a photogrammetry-based approach for deep-sea underwater surveys conducted from a submarine and guided by knowledge-representation combined with a logical approach (ontology). Two major issues are discussed in this paper. The first concerns deep-sea surveys using photogrammetry from a submarine. Here the goal was to obtain a set of images that completely covered the selected site. Subsequently and based on these images, a low-resolution 3D model is obtained in real-time, followed by a very high-resolution model produced back in the laboratory. The second issue involves the extraction of known artefacts present on the site. This aspect of the research is based on an a priori representation of the knowledge involved using systematic reasoning. Two parallel processes were developed to represent the photogrammetric process used for surveying as well as for identifying archaeological artefacts visible on the sea floor. Mapping involved the use of the CIDOC-CRM system (International Committee for Documentation (CIDOC)-Conceptual Reference Model)-This is a system that has been previously utilised to in the heritage sector and is largely available to the established scientific community. The proposed theoretical representation is based on procedural attachment; moreover, a strong link is maintained between the ontological description of the modelled concepts and the Java programming language which permitted 3D structure estimation and modelling based on a set of oriented images. A very recently discovered shipwreck acted as a testing ground for this project; the Xelendi Phoenician shipwreck, found off the Maltese coast, is probably the oldest known shipwreck in the western Mediterranean. The approach presented in this paper was developed in the scope of the GROPLAN project (Généralisation du Relevé, avec Ontologies et Photogrammétrie, pour l'Archéologie Navale et Sous-marine). Financed by the French National Research Agency (ANR) for four years

  7. International study of objectively measured physical activity and sedentary time with body mass index and obesity

    DEFF Research Database (Denmark)

    Dyck, D Van; Cerin, E; De Bourdeaudhuij, I

    2015-01-01

    Background:Physical activity (PA) has been consistently implicated in the etiology of obesity, whereas recent evidence on the importance of sedentary time remains inconsistent. Understanding of dose-response associations of PA and sedentary time with overweight and obesity in adults can be improved...... effects of study site and gender.Methods:Data from the International Physical activity and the Environment Network (IPEN) Adult study were used. IPEN Adult is an observational multi-country cross-sectional study, and 12 sites in 10 countries are included. Participants wore an accelerometer for seven...

  8. CANTAB object recognition and language tests to detect aging cognitive decline: an exploratory comparative study

    Directory of Open Access Journals (Sweden)

    Cabral Soares F

    2014-12-01

    Full Text Available Fernanda Cabral Soares,1 Thaís Cristina Galdino de Oliveira,1 Liliane Dias e Dias de Macedo,1 Alessandra Mendonça Tomás,1 Domingos Luiz Wanderley Picanço-Diniz,2 João Bento-Torres,1,3 Natáli Valim Oliver Bento-Torres,1,3 Cristovam Wanderley Picanço-Diniz1 1Universidade Federal do Pará, Instituto de Ciências Biológicas, Hospital Universitário João de Barros Barreto, Laboratório de Investigações em Neurodegeneração e Infecção Belém, Pará, Brazil; 2Universidade Federal do Oeste do Pará, Núcleo Universitário de Oriximiná, Oriximiná, Pará, Brazil; 3Faculdade de Fisioterapia e Terapia Ocupacional, Universidade Federal do Pará, Belém, Pará, BrazilObjective: The recognition of the limits between normal and pathological aging is essential to start preventive actions. The aim of this paper is to compare the Cambridge Neuropsychological Test Automated Battery (CANTAB and language tests to distinguish subtle differences in cognitive performances in two different age groups, namely young adults and elderly cognitively normal subjects.Method: We selected 29 young adults (29.9±1.06 years and 31 older adults (74.1±1.15 years matched by educational level (years of schooling. All subjects underwent a general assessment and a battery of neuropsychological tests, including the Mini Mental State Examination, visuospatial learning, and memory tasks from CANTAB and language tests. Cluster and discriminant analysis were applied to all neuropsychological test results to distinguish possible subgroups inside each age group.Results: Significant differences in the performance of aged and young adults were detected in both language and visuospatial memory tests. Intragroup cluster and discriminant analysis revealed that CANTAB, as compared to language tests, was able to detect subtle but significant differences between the subjects.Conclusion: Based on these findings, we concluded that, as compared to language tests, large-scale application

  9. The healthy building intervention study: Objectives, methods and results of selected environmental measurements

    Energy Technology Data Exchange (ETDEWEB)

    Fisk, W.J.; Faulkner, D.; Sullivan, D. [and others

    1998-02-17

    To test proposed methods for reducing SBS symptoms and to learn about the causes of these symptoms, a double-blind controlled intervention study was designed and implemented. This study utilized two different interventions designed to reduce occupants` exposures to airborne particles: (1) high efficiency filters in the building`s HVAC systems; and (2) thorough cleaning of carpeted floors and fabric-covered chairs with an unusually powerful vacuum cleaner. The study population was the workers on the second and fourth floors of a large office building with mechanical ventilation, air conditioning, and sealed windows. Interventions were implemented on one floor while the occupants on the other floor served as a control group. For the enhanced-filtration intervention, a multiple crossover design was used (a crossover is a repeat of the experiment with the former experimental group as the control group and vice versa). Demographic and health symptom data were collected via an initial questionnaire on the first study week and health symptom data were obtained each week, for eight additional weeks, via weekly questionnaires. A large number of indoor environmental parameters were measured during the study including air temperatures and humidities, carbon dioxide concentrations, particle concentrations, concentrations of several airborne bioaerosols, and concentrations of several microbiologic compounds within the dust sampled from floors and chairs. This report describes the study methods and summarizes the results of selected environmental measurements.

  10. Concurrent Chemoradiotherapy Followed by Consolidation Chemotherapy With Bi-Weekly Docetaxel and Carboplatin for Stage III Unresectable, Non-Small-Cell Lung Cancer: Clinical Application of a Protocol Used in a Previous Phase II Study

    Energy Technology Data Exchange (ETDEWEB)

    Saitoh, Jun-Ichi, E-mail: junsaito@sannet.ne.jp [Division of Radiation Oncology, Saitama Cancer Center, Saitama (Japan); Saito, Yoshihiro; Kazumoto, Tomoko; Kudo, Shigehiro; Yoshida, Daisaku; Ichikawa, Akihiro [Division of Radiation Oncology, Saitama Cancer Center, Saitama (Japan); Sakai, Hiroshi; Kurimoto, Futoshi [Division of Respiratory Disease, Saitama Cancer Center, Saitama (Japan); Kato, Shingo [Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan); Shibuya, Kei [Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma (Japan)

    2012-04-01

    Purpose: To assess the clinical applicability of a protocol evaluated in a previously reported phase II study of concurrent chemoradiotherapy followed by consolidation chemotherapy with bi-weekly docetaxel and carboplatin in patients with stage III, unresectable, non-small-cell lung cancer (NSCLC). Methods and Materials: Between January 2000 and March 2006, 116 previously untreated patients with histologically proven, stage III NSCLC were treated with concurrent chemoradiotherapy. Radiation therapy was administered in 2-Gy daily fractions to a total dose of 60 Gy in combination with docetaxel, 30 mg/m{sup 2}, and carboplatin at an area under the curve value of 3 every 2 weeks during and after radiation therapy. Results: The median survival time for the entire group was 25.5 months. The actuarial 2-year and 5-year overall survival rates were 53% and 31%, respectively. The 3-year cause-specific survival rate was 60% in patients with stage IIIA disease, whereas it was 35% in patients with stage IIIB disease (p = 0.007). The actuarial 2-year and 5-year local control rates were 62% and 55%, respectively. Acute hematologic toxicities of Grade {>=}3 severity were observed in 20.7% of patients, while radiation pneumonitis and esophagitis of Grade {>=}3 severity were observed in 2.6% and 1.7% of patients, respectively. Conclusions: The feasibility of the protocol used in the previous phase II study was reconfirmed in this series, and excellent treatment results were achieved.

  11. Concurrent Chemoradiotherapy Followed by Consolidation Chemotherapy With Bi-Weekly Docetaxel and Carboplatin for Stage III Unresectable, Non-Small-Cell Lung Cancer: Clinical Application of a Protocol Used in a Previous Phase II Study

    International Nuclear Information System (INIS)

    Saitoh, Jun-Ichi; Saito, Yoshihiro; Kazumoto, Tomoko; Kudo, Shigehiro; Yoshida, Daisaku; Ichikawa, Akihiro; Sakai, Hiroshi; Kurimoto, Futoshi; Kato, Shingo; Shibuya, Kei

    2012-01-01

    Purpose: To assess the clinical applicability of a protocol evaluated in a previously reported phase II study of concurrent chemoradiotherapy followed by consolidation chemotherapy with bi-weekly docetaxel and carboplatin in patients with stage III, unresectable, non-small-cell lung cancer (NSCLC). Methods and Materials: Between January 2000 and March 2006, 116 previously untreated patients with histologically proven, stage III NSCLC were treated with concurrent chemoradiotherapy. Radiation therapy was administered in 2-Gy daily fractions to a total dose of 60 Gy in combination with docetaxel, 30 mg/m 2 , and carboplatin at an area under the curve value of 3 every 2 weeks during and after radiation therapy. Results: The median survival time for the entire group was 25.5 months. The actuarial 2-year and 5-year overall survival rates were 53% and 31%, respectively. The 3-year cause-specific survival rate was 60% in patients with stage IIIA disease, whereas it was 35% in patients with stage IIIB disease (p = 0.007). The actuarial 2-year and 5-year local control rates were 62% and 55%, respectively. Acute hematologic toxicities of Grade ≥3 severity were observed in 20.7% of patients, while radiation pneumonitis and esophagitis of Grade ≥3 severity were observed in 2.6% and 1.7% of patients, respectively. Conclusions: The feasibility of the protocol used in the previous phase II study was reconfirmed in this series, and excellent treatment results were achieved.

  12. Extended objects

    International Nuclear Information System (INIS)

    Creutz, M.

    1976-01-01

    After some disconnected comments on the MIT bag and string models for extended hadrons, I review current understanding of extended objects in classical conventional relativistic field theories and their quantum mechanical interpretation

  13. Qualification study of LiF flight crystals for the objective crystal spectrometer on the SPECTRUM-X-GAMMA satellite

    DEFF Research Database (Denmark)

    Christensen, Finn Erland; Rasmussen, I.; Schnopper, Herbert W.

    1992-01-01

    The Objective Crystal Spectrometer (OXS) on the SPECTRUM-X-GAMMA satellite will carry these types of natural crystals LiF(220), Ge(111) and RAP(001). They will be used to study, among others, the H- and the He-like emission from the cosmically important elements Fe, S, Ar and O. More than 300 Li...

  14. The Role of Shape in Semantic Memory Organization of Objects : An Experimental Study Using PI-Release

    NARCIS (Netherlands)

    van Weelden, L.; Schilperoord, J.; Swerts, M.G.J.; Pecher, D.

    2015-01-01

    Visual information contributes fundamentally to the process of object categorization. The present study investigated whether the degree of activation of visual information in this process is dependent on the contextual relevance of this information. We used the Proactive Interference (PI-release)

  15. [Experience of the development special medical technical laboratory for studies of effects caused by potent electromagnetic radiation in biologic objects].

    Science.gov (United States)

    Gorodetsky, B N; Kalyada, T V; Petrov, S V

    2015-01-01

    This article covers topics of creating special medical technical laboratory for medial and biologic studies concerning influence of potent high-frequency elecromagnetic radiation on various biologic objects. The authors gave example of such laboratory, described its construction features, purpose and main characteristics of the included devices.

  16. A Study of the Development of Students' Visualizations of Program State during an Elementary Object-Oriented Programming Course

    Science.gov (United States)

    Sajaniemi, Jorma; Kuittinen, Marja; Tikansalo, Taina

    2008-01-01

    Students' understanding of object-oriented (OO) program execution was studied by asking students to draw a picture of a program state at a specific moment. Students were given minimal instructions on what to include in their drawings in order to see what they considered to be central concepts and relationships in program execution. Three drawing…

  17. Trusted Objects

    International Nuclear Information System (INIS)

    CAMPBELL, PHILIP L.; PIERSON, LYNDON G.; WITZKE, EDWARD L.

    1999-01-01

    In the world of computers a trusted object is a collection of possibly-sensitive data and programs that can be allowed to reside and execute on a computer, even on an adversary's machine. Beyond the scope of one computer we believe that network-based agents in high-consequence and highly reliable applications will depend on this approach, and that the basis for such objects is what we call ''faithful execution.''

  18. Subsequent childbirth after a previous traumatic birth.

    Science.gov (United States)

    Beck, Cheryl Tatano; Watson, Sue

    2010-01-01

    Nine percent of new mothers in the United States who participated in the Listening to Mothers II Postpartum Survey screened positive for meeting the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for posttraumatic stress disorder after childbirth. Women who have had a traumatic birth experience report fewer subsequent children and a longer length of time before their second baby. Childbirth-related posttraumatic stress disorder impacts couples' physical relationship, communication, conflict, emotions, and bonding with their children. The purpose of this study was to describe the meaning of women's experiences of a subsequent childbirth after a previous traumatic birth. Phenomenology was the research design used. An international sample of 35 women participated in this Internet study. Women were asked, "Please describe in as much detail as you can remember your subsequent pregnancy, labor, and delivery following your previous traumatic birth." Colaizzi's phenomenological data analysis approach was used to analyze the stories of the 35 women. Data analysis yielded four themes: (a) riding the turbulent wave of panic during pregnancy; (b) strategizing: attempts to reclaim their body and complete the journey to motherhood; (c) bringing reverence to the birthing process and empowering women; and (d) still elusive: the longed-for healing birth experience. Subsequent childbirth after a previous birth trauma has the potential to either heal or retraumatize women. During pregnancy, women need permission and encouragement to grieve their prior traumatic births to help remove the burden of their invisible pain.

  19. A Twin Study of Objective and Subjective Pubertal Timing and Peer Influence on Risk-Taking.

    Science.gov (United States)

    Kretsch, Natalie; Mendle, Jane; Harden, K Paige

    2016-03-01

    The current study used a behavioral genetic design to test whether three measures of pubertal timing moderated peer influence on risk-taking in a sample of 248 female adolescent twin pairs ( M age =16.0, SD =1.5) from the National Longitudinal Study of Adolescent Health. Peer influence was operationalized as the quasi-causal association between girls' self-reported risk-taking and the risk-taking reported by their friends. Girls with earlier ages at menarche and who perceived themselves as more developed than peers were more susceptible to peer influence on risk-taking. However, age-standardized ratings of body changes did not moderate peer influence. This study highlights distinctions between multiple measures of pubertal timing, using an innovative synthesis of genetically informative data and peer nomination data.

  20. Laugh and Smile upon the Holy Quran: The Study of Analytical Objectivities

    Science.gov (United States)

    al-Domi, Mohammad Mahmoud

    2015-01-01

    This study aims to examine the positive impact of The Holy Quran based on the laugh and smile. This kind of derivatives in which context of praise, expression the feeling of happiness and joyful in the positive senses. Everyone needs to relieve his heart so that happiness and joy on their faces can be seen. Laughter also are some of attribute…

  1. Study to validate the outcome goal, competencies and educational objectives for use in intensive care orientation programs.

    Science.gov (United States)

    Boyle, M; Butcher, R; Kenney, C

    1998-03-01

    Intensive care orientation programs have become an accepted component of intensive care education. To date, however, there have been no Australian-based standards defining the appropriate level of competence to be attained upon completion of orientation. The aim of this study was to validate a set of aims, competencies and educational objectives that could form the basis of intensive care orientation and which would ensure an outcome standard of safe and effective practice. An initial document containing a statement of the desired outcome goal, six competency statements and 182 educational objectives was developed through a review of the orientation programs developed by the investigators. The Delphi technique was used to gain consensus among 13 nurses recognised for their expertise in intensive care education. The expert group rated the acceptability of each of the study items and provided suggestions for objectives to be included. An approval rating of 80 per cent was required to retain each of the study items, with the document refined through three Delphi rounds. The final document contains a validated statement of outcome goal, competencies and educational objectives for intensive care orientation programs.

  2. Case Study: On Objective Functions for the Peak Flow Calibration and for the Representative Parameter Estimation of the Basin

    Directory of Open Access Journals (Sweden)

    Jungwook Kim

    2018-05-01

    Full Text Available The objective function is usually used for verification of the optimization process between observed and simulated flows for the parameter estimation of rainfall–runoff model. However, it does not focus on peak flow and on representative parameter for various rain storm events of the basin, but it can estimate the optimal parameters by minimizing the overall error of observed and simulated flows. Therefore, the aim of this study is to suggest the objective functions that can fit peak flow in hydrograph and estimate the representative parameter of the basin for the events. The Streamflow Synthesis And Reservoir Regulation (SSARR model was employed to perform flood runoff simulation for the Mihocheon stream basin in Geum River, Korea. Optimization was conducted using three calibration methods: genetic algorithm, pattern search, and the Shuffled Complex Evolution method developed at the University of Arizona (SCE-UA. Two objective functions of the Sum of Squared of Residual (SSR and the Weighted Sum of Squared of Residual (WSSR suggested in this study for peak flow optimization were applied. Since the parameters estimated using a single rain storm event do not represent the parameters for various rain storms in the basin, we used the representative objective function that can minimize the sum of objective functions of the events. Six rain storm events were used for the parameter estimation. Four events were used for the calibration and the other two for validation; then, the results by SSR and WSSR were compared. Flow runoff simulation was carried out based on the proposed objective functions, and the objective function of WSSR was found to be more useful than that of SSR in the simulation of peak flow runoff. Representative parameters that minimize the objective function for each of the four rain storm events were estimated. The calibrated observed and simulated flow runoff hydrographs obtained from applying the estimated representative

  3. Non-destructive analysis in a study of the religious art objects

    International Nuclear Information System (INIS)

    Vornicu, Nicoleta; Bibire, Cristina; Geba, Maria

    2009-01-01

    The icon Descending of the Saint Spirit from Bucium Church, dating in the year 1814 and was done in tempera on wood technology. The characterization of cultural heritage materials is essential for the comprehension of their degradation mechanisms. The present study aims at identifying the pigments in the various layers, establishing the possible existence of an organic binder and scientifically evaluating the state of preservation. To this end, were used non-destructive methods, as: microscopic (SEM), XRF and spectroscopic (FTIR).

  4. Rationale, design and objectives of ARegPKD, a European ARPKD registry study.

    Science.gov (United States)

    Ebner, Kathrin; Feldkoetter, Markus; Ariceta, Gema; Bergmann, Carsten; Buettner, Reinhard; Doyon, Anke; Duzova, Ali; Goebel, Heike; Haffner, Dieter; Hero, Barbara; Hoppe, Bernd; Illig, Thomas; Jankauskiene, Augustina; Klopp, Norman; König, Jens; Litwin, Mieczyslaw; Mekahli, Djalila; Ranchin, Bruno; Sander, Anja; Testa, Sara; Weber, Lutz Thorsten; Wicher, Dorota; Yuzbasioglu, Ayse; Zerres, Klaus; Dötsch, Jörg; Schaefer, Franz; Liebau, Max Christoph

    2015-02-18

    Autosomal recessive polycystic kidney disease (ARPKD) is a rare but frequently severe disorder that is typically characterized by cystic kidneys and congenital hepatic fibrosis but displays pronounced phenotypic heterogeneity. ARPKD is among the most important causes for pediatric end stage renal disease and a leading reason for liver-, kidney- or combined liver kidney transplantation in childhood. The underlying pathophysiology, the mechanisms resulting in the observed clinical heterogeneity and the long-term clinical evolution of patients remain poorly understood. Current treatment approaches continue to be largely symptomatic and opinion-based even in most-advanced medical centers. While large clinical trials for the frequent and mostly adult onset autosomal dominant polycystic kidney diseases have recently been conducted, therapeutic initiatives for ARPKD are facing the challenge of small and clinically variable cohorts for which reliable end points are hard to establish. ARegPKD is an international, mostly European, observational study to deeply phenotype ARPKD patients in a pro- and retrospective fashion. This registry study is conducted with the support of the German Society for Pediatric Nephrology (GPN) and the European Study Consortium for Chronic Kidney Disorders Affecting Pediatric Patients (ESCAPE Network). ARegPKD clinically characterizes long-term ARPKD courses by a web-based approach that uses detailed basic data questionnaires in combination with yearly follow-up visits. Clinical data collection is accompanied by associated biobanking and reference histology, thus setting roots for future translational research. The novel registry study ARegPKD aims to characterize miscellaneous subcohorts and to compare the applied treatment options in a large cohort of deeply characterized patients. ARegPKD will thus provide evidence base for clinical treatment decisions and contribute to the pathophysiological understanding of this severe inherited disorder.

  5. Predictive factors for the development of diabetes in women with previous gestational diabetes mellitus

    DEFF Research Database (Denmark)

    Damm, P.; Kühl, C.; Bertelsen, Aksel

    1992-01-01

    OBJECTIVES: The purpose of this study was to determine the incidence of diabetes in women with previous dietary-treated gestational diabetes mellitus and to identify predictive factors for development of diabetes. STUDY DESIGN: Two to 11 years post partum, glucose tolerance was investigated in 241...... women with previous dietary-treated gestational diabetes mellitus and 57 women without previous gestational diabetes mellitus (control group). RESULTS: Diabetes developed in 42 (17.4%) women with previous gestational diabetes mellitus (3.7% insulin-dependent diabetes mellitus and 13.7% non...... of previous patients with gestational diabetes mellitus in whom plasma insulin was measured during an oral glucose tolerance test in late pregnancy a low insulin response at diagnosis was found to be an independent predictive factor for diabetes development. CONCLUSIONS: Women with previous dietary...

  6. Drosophila as a model object in to study Chernobyl NPP after

    International Nuclear Information System (INIS)

    Marinenko, T.V.; Kozeretskaya, I.A.; Gorodetski, G.V.

    2007-01-01

    Complete text of publication follows. Water extractions of soil probes, which were selected on areas with different density of radioactive pollutions near Chernobyl exclusion zone ('Apple-tree garden' (Chernobyl); 'Island' (the bank of the pond-cooler of the Chernobyl nuclear power plant); 'Torch' (the area of revegetation near the Chernobyl nuclear power plant); 'Red forest' (side of a road) and 'Red forest' (edge of a forest)) were investigated. Dosimetric metering of all studied areas was conducted. γ- and β-activities of soil probes were determined by spectrometry and radiochemistry methods. The contents of trace elements in the soil probes of areas the 'Appletree garden' and 'Island' were determined. Water extractions from soil were prepared according to standard method (ratio - 1 : 2,5). The mutagenicity of water extractions of soil was estimated using the test of frequency of the sex-linked lethal mutations of Drosophila melanogaster. Water extractions were directly adds to a nourishing medium instead of standard component - distilled water. The strain of wild type of Drosophila Canton-S and natural populations of Drosophila from Pyriatin and Chernobyl were used in our study. The natural populations of Chernobyl and Pyriatin were included in study for more fully estimation of influence of factor on genetic processes of Drosophila, because of presence of unspecific adaptations of natural populations from radioactive polluted territories (as was shown before). According to dosimetric analysis data radiation activity of all water extractions of soils did not exceed a natural background. The probes of soil from areas the 'Red forest' and the 'Torch' were marked the higher activity; total activity of them was over 110 Mbk/kg. It is possibly that this fact was the reason of the absence of descendants in all variants of experiments conducted on medium with water extraction the 'Red forest' and in a variant of experiments concerned on study of activity of water

  7. Economic system as the basic object of study in the general educational institutions

    Directory of Open Access Journals (Sweden)

    Михаил Бурла

    2017-09-01

    Full Text Available This article analyzes the prevailing practice of studying the economies at different levels in schools of Moldova, Russia and Ukraine. The main attention is paid to the development of methods of studying modern conceptual device that describes the nature, composition, structure and parameters of economic systems in educational institutions. In modern textbooks that are currently used in general education institutions there are some basic concepts and indicators, which allow to fully understand the world economy, economy of states and regions. There are such categories as “economic system”, “model of the economy”, “structure of the economy”, “the branch of the economy”, “sphere of economy”, “sector of economy”. The analysis of school textbooks on geography and other subjects indicates the need for detailed assimilation of information concerning systems, their types, composition, structure and functions. The study of economic and social geography should be paid main attention to the economic system. This article presents the author’s version of the “economic system” concept’s interpretation with all its constituent elements, reveals the functions of economic systems, the types of economic products and services produced by them, examines the levels from global to local ones with specific examples. Various types of economic structures are shown: 1 sectoral, reflecting the relationship between industries; 2 interbranch, reflecting the relationship between interindustry complexes; 3 territorial, reflecting the share of individual regions in national indicators or the share of countries in global indicators, as well as the spatial location of production and non-production facilities; 4 tiered, reflecting the relationship between the primary, secondary and tertiary sectors of the economy; 5 two-sphere, reflecting the relationship between the production and non-production spheres; 6 organizational and legal, reflecting the

  8. The Neutron, a Tool and an Object for Fundamental and Nuclear Physics Studies

    CERN Multimedia

    CERN. Geneva

    2004-01-01

    The Institut Laue-Langevin (ILL) is an international research institute which operates the currently most powerful source of neutrons in the world, a 58 MW reactor. The neutron beams provided by the reactor feed a broad range of instruments which are dedicated to a wide variety of research activities. The majority of instruments are dedicated to the study of solid-state physics, materials science, chemistry, the biosciences, and earth sciences. However, nuclear and low energy particle physics studies are also vigorously pursued with the aid of neutrons. The talk will mainly concentrate on this latter aspect. We make use of hot, thermal, cold, and ultra-cold neutrons with velocities of between a few kilometers and a few meters per second, corresponding to kinetic energies in the electronvolt-to-nanoelectronvolt range. It will be briefly discussed how thermal neutrons can be used to investigate the structure and behavior of nuclei by generating excited nuclear states. The main part of the talk will be dedicated...

  9. Objectively measured sleep and β-amyloid burden in older adults: A pilot study

    Directory of Open Access Journals (Sweden)

    Adam P Spira

    2014-08-01

    Full Text Available Background/aims: Although disturbed sleep is associated with cognitive deficits, the association between sleep disturbance and Alzheimer’s disease pathology is unclear. In this pilot study, we examined the extent to which sleep duration, sleep quality, and sleep-disordered breathing are associated with β-amyloid (Aβ deposition in the brains of living humans. Methods: We studied 13 older adults (8 with normal cognition and 5 with mild cognitive impairment. Participants completed neuropsychological testing, polysomnography, and Aβ imaging with [11C]-Pittsburgh compound B. Results: Among participants with mild cognitive impairment, higher apnea–hypopnea index and oxygen desaturation index were associated with greater Aβ deposition, globally and regionally in the precuneus. There were no significant associations between sleep-disordered breathing and Aβ deposition among cognitively normal participants. There were no significant associations between sleep duration or sleep fragmentation and Aβ deposition. Conclusion: These preliminary results suggest that among older adults with mild cognitive impairment, greater sleep-disordered breathing severity is associated with greater Aβ deposition.

  10. Modeling methods for systems study of geomechanical and mining technological objects

    Energy Technology Data Exchange (ETDEWEB)

    Glazov, D D

    1983-01-01

    Of the basic classes of problems solved during the accepted systems examination of the results of full scale, laboratory and analytical studies, the following are noted: the problems of detecting patterns in the limited empirical base and isolating new physical content in the phenomena which have not received effective explanation within the exhaustive use of the arsenal of traditional methods and techniques; problems for describing the subject field of complex natural systems through isolating their system models in the chaos of contradictory information as the bases for building automated systems for decision making; terminological questions; problems in determining the systems parameters and building structural models of new technologies which provide for dividing the physical effect by levels of geomechanical systems. Thus, at the present time studies of multilevel accepted models of organization of geomechanical systems are interpreted in new methods of structuring by an explosion of roofs difficult to collapse based on its screen creating and multiscreen grinding effect, introduced jointly by the DonUGI at the mines of the Donbass, and new methods for building technological systems for passage by complexes of geological disruptions introduced jointly with the IGD im. Skochinskiy in the Kuzbass and in the Mosbass.

  11. Objective assessment of occlusal and coronal characteristics of untreated normals: a measurement study.

    Science.gov (United States)

    Currim, Simone; Wadkar, Prabodh V

    2004-05-01

    To determine whether tooth shape and position are constant within tooth types, dental casts of 68 Indians (age range, 10-32 years; mean, 18.72 years) were analyzed. The casts were selected from a larger sample and met the following criteria: Class I molar and canine relationships; overjet and overbite within normal limits; well-related vertical, transverse, and anteroposterior relationships with pleasing profiles and well-aligned arches; and no supernumerary teeth or large restorations. None of the subjects had received orthodontic treatment, and all were in good health and exhibited normal growth. Crown angulation, inclination, offset of maxillary molar, curve of Spee, crown facial prominence, horizontal crown contour, and vertical crown contour were assessed. Means, standard deviations, and standard errors were calculated. The measurements were compared with Andrews's data on 120 nonorthodontic normal occlusion casts. The Student t test was used to determine the significance of differences between the 2 sets of data. It was found that teeth of the same tooth type have similar values of horizontal and vertical crown contours. Values for inclination, angulation, and relative prominence were also similar. Hence, we concluded that tooth shape and position are constant for each tooth type. The data from this study were comparable with Andrews's findings. However, from this study, it would be safe to presume that all teeth except the maxillary second molars require alterations in the bracket base inclination value, and that the maxillary lateral incisor, canine, second premolar, and second molar, and the mandibular canine, require alterations in angulation values.

  12. Influence of personality on objective and subjective social support among patients with major depressive disorder: a prospective study.

    Science.gov (United States)

    Leskelä, Ulla; Melartin, Tarja; Rytsälä, Heikki; Jylhä, Pekka; Sokero, Petteri; Lestelä-Mielonen, Paula; Isometsä, Erkki

    2009-10-01

    Personality and social support (SS) influence risk for depression and modify its outcome through multiple pathways. The impact of personality dimensions neuroticism and extraversion on SS among patients with major depressive disorder (MDD) has been little studied. In the Vantaa Depression Study, we assessed neuroticism and extraversion with the Eysenck Personality Inventory, objective SS with the Interview Measure of Social Relationships, and subjective SS with the Perceived Social Support Scale-Revised at baseline, at 6 and 18 months among 193 major depressive disorder patients diagnosed according to the fourth edition of Diagnostic and Statistical Manual of Mental Disorders (DMS-IV). At all time-points, low neuroticism and high extraversion associated significantly with between-subject differences in levels of objective and subjective SS. Lower neuroticism (beta = 0.213, p = 0.003) and higher extraversion (beta = 0.159, p = 0.038) predicted greater within-subject change of subjective, but not objective SS. Thus, neuroticism and extraversion associated with the size of objective and subjective SS and predicted change of subjective SS. Modification of subjective SS, particularly, may indirectly influence future vulnerability to depression.

  13. Object relations and interpersonal problems in sexually abused female patients: an empirical study with the SCORS and the IIP.

    Science.gov (United States)

    Kernhof, Karin; Kaufhold, Johannes; Grabhorn, Ralph

    2008-01-01

    In this study, we examined how retrospective reports of experiencing traumatic sexual abuse in childhood relates to both the development of self-representations and object representations and the occurrence of interpersonal problems. A total of 30 psychosomatic female patients who reported sexual abuse in childhood were compared with a corresponding number of eating-disordered patients and a nonclinical control group. The object relations technique (ORT; Phillipson, 1955), evaluated using the Social Cognition and Object Relations Scale (SCORS; Westen, 1985, 1991b), and the Inventory of Interpersonal Problems (Horowitz, Rosenberg, Baer, & Ureno, 1988) were used to measure the groups. The patients reporting sexual abuse achieved significantly lower scores in the cognitive scales of the SCORS; in the affective scales, they differed from the control group but not from the patients with an eating disorder. Concerning interpersonal problems, the patients reporting childhood sexual abuse reported interpersonal conflicts more frequently. The results of the study support the influence of traumatic sexual abuse on the formation of self-representations and object representations and on the occurrence of interpersonal conflicts.

  14. An experimental and multi-objective optimization study of a forced draft cooling tower with different fills

    International Nuclear Information System (INIS)

    Singh, Kuljeet; Das, Ranjan

    2016-01-01

    Highlights: • Experimental and optimization study on forced draft cooling tower is done. • New correlations for splash, trickle and film type fills are proposed. • Multi-objective performance optimization study has been done using NSGA-II. • Weighted decision making criterion is proposed depending upon user priority. • Proposed generalized methodology can be implemented in industrial cooling towers. - Abstract: In the present study, a forced draft mechanical cooling tower has been experimentally investigated using trickle, film and splash fills. Various performance parameters such as range, tower characteristic ratio, effectiveness and water evaporation rate are first analyzed for each fill. Thereafter, based upon the experimental data, pertinent correlations have been developed for performance parameters by considering mass flow rates of water and air as design variables. Each of the performance parameters is considered to be an individual objective function and all objectives are then simultaneously optimized for maximizing the performance of the cooling tower using elitist Non-Dominated Sorting Genetic Algorithm (NSGA-II). The multi-objective optimization algorithm gives a set of possible combinations of design variables, which is referred as the optimal Pareto-front, out of which a unique combination is selected based upon a decision making criterion. The proposed decision making procedure evaluates a Decision Making Score (DMS) based on assigned performance priorities for each point of the Pareto-front. Depending on DMS a unique combination of design variables is then selected for each type of fill that maximizes the tower’s performance. These optimal points and the corresponding objective function are finally compared and based upon the highest DMS value, the wire-mesh (trickle) fill is found to be the most efficient fill under the present experimental conditions. The methodology presented in this work has been made more generalized, so that it

  15. Object-action dissociation: A voxel-based lesion-symptom mapping study on 102 patients after glioma removal

    Directory of Open Access Journals (Sweden)

    Alberto Pisoni

    Full Text Available Data concerning the neural basis of noun and verb processing are inconsistent. Some authors assume that action-verb processing is based on frontal areas while nouns processing relies on temporal regions; others argue that the circuits processing verbs and nouns are closely interconnected in a predominantly left-lateralized fronto-temporal-parietal network; yet, other researchers consider that the primary motor cortex plays a crucial role in processing action verbs. In the present study, one hundred and two patients with a tumour either in the right or left hemisphere were submitted to picture naming of objects and actions before and after surgery. To test the effect of specific brain regions in object and action naming, patients' lesions were mapped and voxel-lesion-symptom mapping (VLSM was computed. Behavioural results showed that left-brain damaged patients were significantly more impaired than right brain-damaged patients. The VLSM showed that these two grammatical classes are segregated in the left hemisphere. In particular, scores in naming of objects correlated with damage to the anterior temporal region, while scores in naming of actions correlated with lesions in the parietal areas and in the posterior temporal cortex. In addition, VLSM analyses carried out on non-linguistic tasks were not significant, confirming that the regions associated with deficits in object and action naming were not generally engaged in all cognitive tasks. Finally, the involvement of subcortical pathways was investigated and the inferior longitudinal fasciculus proved to play a role in object naming, while no specific bundle was identified for actions. Keywords: Object action dissociation, Temporal lesion, Frontal lesion, Voxel-based lesion symptom mapping

  16. Non-dystrophic myotonia: prospective study of objective and patient reported outcomes.

    Science.gov (United States)

    Trivedi, Jaya R; Bundy, Brian; Statland, Jeffrey; Salajegheh, Mohammad; Rayan, Dipa Raja; Venance, Shannon L; Wang, Yunxia; Fialho, Doreen; Matthews, Emma; Cleland, James; Gorham, Nina; Herbelin, Laura; Cannon, Stephen; Amato, Anthony; Griggs, Robert C; Hanna, Michael G; Barohn, Richard J

    2013-07-01

    Non-dystrophic myotonias are rare diseases caused by mutations in skeletal muscle chloride and sodium ion channels with considerable phenotypic overlap between diseases. Few prospective studies have evaluated the sensitivity of symptoms and signs of myotonia in a large cohort of patients. We performed a prospective observational study of 95 participants with definite or clinically suspected non-dystrophic myotonia recruited from six sites in the USA, UK and Canada between March 2006 and March 2009. We used the common infrastructure and data elements provided by the NIH-funded Rare Disease Clinical Research Network. Outcomes included a standardized symptom interview and physical exam; the Short Form-36 and the Individualized Neuromuscular Quality of Life instruments; electrophysiological short and prolonged exercise tests; manual muscle testing; and a modified get-up-and-go test. Thirty-two participants had chloride channel mutations, 34 had sodium channel mutations, nine had myotonic dystrophy type 2, one had myotonic dystrophy type 1, and 17 had no identified mutation. Phenotype comparisons were restricted to those with sodium channel mutations, chloride channel mutations, and myotonic dystrophy type 2. Muscle stiffness was the most prominent symptom overall, seen in 66.7% to 100% of participants. In comparison with chloride channel mutations, participants with sodium mutations had an earlier age of onset of stiffness (5 years versus 10 years), frequent eye closure myotonia (73.5% versus 25%), more impairment on the Individualized Neuromuscular Quality of Life summary score (20.0 versus 9.44), and paradoxical eye closure myotonia (50% versus 0%). Handgrip myotonia was seen in three-quarters of participants, with warm up of myotonia in 75% chloride channel mutations, but also 35.3% of sodium channel mutations. The short exercise test showed ≥10% decrement in the compound muscle action potential amplitude in 59.3% of chloride channel participants compared with 27

  17. Irresistible force meets immovable object : an Ontario case study on grid expansion

    Energy Technology Data Exchange (ETDEWEB)

    Vegh, G.; Annis, K. [McCarthy Tetrault, Toronto, ON (Canada)

    2010-07-01

    This PowerPoint presentation discussed a case study of an Ontario grid expansion. The Green Energy and Green Economy Act was introduced in Ontario in 2009. The federal feed-in tariff (FIT) program has been successful, and has resulted in increased renewable energy capacity throughout the province. The expansion in distribution has resulted in the socialization of distribution expansion costs. A cost sharing mechanism has been established to ensure that the amount of rate protection is equal to investment costs. Costs that are the distributor's responsibility are considered to be eligible investment costs, and Green Energy Act plans are required to account for distribution expansion that is built to connect renewable generation. Details of Hydro One Networks' distribution expansion plans were presented. The methods used by the Ontario Energy Board (OEB) to determine which types of generation should be connected were reviewed. The presentation concluded by recommending the development of a generic process for addressing generation and connection cost considerations in order to increase transparency and predictability. Transmission projects and policy changes were also discussed. tabs., figs.

  18. The VA Ostomy Health-Related Quality of Life Study: objectives, methods, and patient sample.

    Science.gov (United States)

    Krouse, Robert S; Mohler, M Jane; Wendel, Christopher S; Grant, Marcia; Baldwin, Carol M; Rawl, Susan M; McCorkle, Ruth; Rosenfeld, Kenneth E; Ko, Clifford Y; Schmidt, C Max; Coons, Stephen Joel

    2006-04-01

    To present the design and methods of a multisite study of health-related quality of life (HR-QOL) in veterans living with ostomies. Veterans from Tucson, Indianapolis, and Los Angeles VA Medical Centers were surveyed using the validated City of Hope ostomy-specific tool (mCOH-QOL-Ostomy) and the SF-36V. Cases (ostomates) had a major gastrointestinal procedure that required an intestinal stoma, while controls had similar procedures for which an ostomy was not required. Ostomy subjects were recruited for four focus groups in each of two sites divided by ostomy type (colostomy versus ileostomy) and overall mCOH-QOL-Ostomy HR-QOL score (highest versus lowest quartile). The focus groups further evaluated barriers, concerns, and adaptation methods and skills. This report presents recruitment results, reliability of survey instruments, and demographic characteristics of the sample. The overall response (i.e., recruitment) rate across all sites was 48% and by site was 53%, 57%, and 37%, respectively (p ostomies had significantly longer time since surgery than controls (p ostomies is an illustration of a successful mixed methods approach to HR-QOL research. We collected meaningful quantitative and qualitative data that will be used in the development of new approaches to care that will lead to improved functioning and well-being in persons living with ostomies. Subsequent reports will provide the results of this research project.

  19. Migrating Home Computer Audio Waveforms to Digital Objects: A Case Study on Digital Archaeology

    Directory of Open Access Journals (Sweden)

    Mark Guttenbrunner

    2011-03-01

    Full Text Available Rescuing data from inaccessible or damaged storage media for the purpose of preserving the digital data for the long term is one of the dimensions of digital archaeology. With the current pace of technological development, any system can become obsolete in a matter of years and hence the data stored in a specific storage media might not be accessible anymore due to the unavailability of the system to access the media. In order to preserve digital records residing in such storage media, it is necessary to extract the data stored in those media by some means.One early storage medium for home computers in the 1980s was audio tape. The first home computer systems allowed the use of standard cassette players to record and replay data. Audio cassettes are more durable than old home computers when properly stored. Devices playing this medium (i.e. tape recorders can be found in working condition or can be repaired, as they are usually made out of standard components. By re-engineering the format of the waveform and the file formats, the data on such media can then be extracted from a digitised audio stream and migrated to a non-obsolete format.In this paper we present a case study on extracting the data stored on an audio tape by an early home computer system, namely the Philips Videopac+ G7400. The original data formats were re-engineered and an application was written to support the migration of the data stored on tapes without using the original system. This eliminates the necessity of keeping an obsolete system alive for enabling access to the data on the storage media meant for this system. Two different methods to interpret the data and eliminate possible errors in the tape were implemented and evaluated on original tapes, which were recorded 20 years ago. Results show that with some error correction methods, parts of the tapes are still readable even without the original system. It also implies that it is easier to build solutions while original

  20. Influence of jet thrust on penetrator penetration when studying the structure of space object blanket

    Directory of Open Access Journals (Sweden)

    N. A. Fedorova

    2014-01-01

    Full Text Available The article presents the calculation-and-theory-based research results to examine the possibility for using the jet thrust impulse to increase a penetration depth of high-velocity penetrator modules. Such devices can be used for studies of Earth surface layer composition, and in the nearest future for other Solar system bodies too. Research equipment (sensors and different instruments is housed inside a metal body of the penetrator with a sharpened nose that decreases drag force in soil. It was assumed, that this penetrator is additionally equipped with the pulse jet engine, which is fired at a certain stage of penetrator motion into target.The penetrator is considered as a rigid body of variable mass, which is subjected to drag force and reactive force applied at the moment the engine fires. A drag force was represented with a binomial empirical law, and penetrator nose part was considered to be conical. The jet thrust force was supposed to be constant during its application time. It was in accordance with assumption that mass flow and flow rate of solid propellant combustion products were constant. The amount of propellant in the penetrator was characterized by Tsiolkovsky number Z, which specifies the ratio between the fuel mass and the penetrator structure mass with no fuel.The system of equations to describe the penetrator dynamics was given in dimensionless form using the values aligned with penetration of an equivalent inert penetrator as the time and penetration depth scales. Penetration dynamics of penetrator represented in this form allowed to eliminate the influence of penetrator initial mass and its cross-section diameter on the solution results. The lack of such dependency is convenient for comparing the calculation results since they hold for penetrators of various initial masses and cross-sections.To calculate the penetration a lunar regolith was taken as a soil material. Calculations were carried out for initial velocities of

  1. Prospective assessment of nocturnal awakenings in a case series of treatment-seeking chronic insomnia patients: a pilot study of subjective and objective causes.

    Science.gov (United States)

    Krakow, Barry; Romero, Edward; Ulibarri, Victor A; Kikta, Shara

    2012-12-01

    The cause of nocturnal awakenings in patients with chronic insomnia is rarely researched. This study prospectively assessed the etiology of nocturnal awakenings (subjectively and objectively) among patients with insomnia at a private, community-based sleep medical center. Twenty adult patients with chronic insomnia enrolled between April 2008 and February 2010 met diagnostic criteria for an insomnia disorder, never previously visited a sleep specialist or underwent sleep testing, and reported no classic sleep disordered breathing symptoms. Patients completed validated scales for insomnia, sleepiness, impairment, anxiety, depression, and quality of life, a qualitative interview to assess subjective reasons for awakenings, and a diagnostic sleep study to objectively assess awakenings and their precipitants. Subjective and objective data showed clinically meaningful insomnia, primarily sleep maintenance insomnia. The most common self-reported reasons for awakenings were: uncertain cause (50%), nightmares (45%), nocturia (35%), bedroom distractions (20%), or pain (15%). No patient identified breathing symptoms as a cause. Objectively, 531 awakenings were observed in the total sample, and 478 (90%) were preceded by sleep breathing events (apnea, hypopnea, or respiratory effort-related event). Fifty-three awakenings were caused by other factors (independent leg jerks [7], spontaneous [14], and sleep that was laboratory-induced [32]). Thirty awakenings ≥ 5 min-a duration sufficient to predispose toward an insomnia episode-were each preceded by a breathing event. Among patients with insomnia with no classic sleep breathing symptoms and therefore low probability of a sleep breathing disorder, most of their awakenings were precipitated by a medical condition (sleep disordered breathing), which contrasted sharply with their perceptions about their awakenings

  2. Study of tonotopic brain changes with functional MRI and FDG-PET in a patient with unilateral objective cochlear tinnitus.

    Science.gov (United States)

    Guinchard, A-C; Ghazaleh, Naghmeh; Saenz, M; Fornari, E; Prior, J O; Maeder, P; Adib, S; Maire, R

    2016-11-01

    We studied possible brain changes with functional MRI (fMRI) and fluorodeoxyglucose positron emission tomography (FDG-PET) in a patient with a rare, high-intensity "objective tinnitus" (high-level SOAEs) in the left ear of 10 years duration, with no associated hearing loss. This is the first case of objective cochlear tinnitus to be investigated with functional neuroimaging. The objective cochlear tinnitus was measured by Spontaneous Otoacoustic Emissions (SOAE) equipment (frequency 9689 Hz, intensity 57 dB SPL) and is clearly audible to anyone standing near the patient. Functional modifications in primary auditory areas and other brain regions were evaluated using 3T and 7T fMRI and FDG-PET. In the fMRI evaluations, a saturation of the auditory cortex at the tinnitus frequency was observed, but the global cortical tonotopic organization remained intact when compared to the results of fMRI of healthy subjects. The FDG-PET showed no evidence of an increase or decrease of activity in the auditory cortices or in the limbic system as compared to normal subjects. In this patient with high-intensity objective cochlear tinnitus, fMRI and FDG-PET showed no significant brain reorganization in auditory areas and/or in the limbic system, as reported in the literature in patients with chronic subjective tinnitus. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. The predictive effect of fear-avoidance beliefs on low back pain among newly qualified health care workers with and without previous low back pain: a prospective cohort study

    DEFF Research Database (Denmark)

    Jensen, Jette Nygaard; Albertsen, Karen; Borg, Vilhelm

    2009-01-01

    Health care workers have a high prevalence of low back pain (LBP). Although physical exposures in the working environment are linked to an increased risk of LBP, it has been suggested that individual coping strategies, for example fear-avoidance beliefs, could also be important in the development...... and maintenance of LBP. Accordingly, the main objective of this study was to examine (1) the association between physical work load and LBP, (2) the predictive effect of fear-avoidance beliefs on the development of LBP, and (3) the moderating effect of fear-avoidance beliefs on the association between physical...

  4. A multicenter study on objective and subjective benefits with a transcutaneous bone-anchored hearing aid device

    DEFF Research Database (Denmark)

    Hougaard, Dan Dupont; Boldsen, Soren Kjaergaard; Jensen, Anne Marie

    2017-01-01

    Examination of objective as well as subjective outcomes with a new transcutaneous bone-anchored hearing aid device. The study was designed as a prospective multicenter consecutive case-series study involving tertiary referral centers at two Danish University Hospitals. A total of 23 patients were...... implanted. Three were lost to follow-up. Patients had single-sided deafness, conductive or mixed hearing loss. Intervention: Rehabilitative. Aided and unaided sound field hearing was evaluated objectively using (1) pure warble tone thresholds, (2) pure-tone average (PTA4), (3) speech discrimination score...... (SDS) in quiet, and (4) speech reception threshold 50% at 70 dB SPL noise level (SRT50%). Subjective benefit was evaluated by three validated questionnaires: (1) the IOI-HA, (2) the SSQ-12, and (3) a questionnaire evaluating both the frequency and the duration of hearing aid usage. The mean aided PTA4...

  5. Are objective measures of tricuspid annular motion and velocity used as frequently as recommended by current guidelines? A pilot study

    Directory of Open Access Journals (Sweden)

    Angel López-Candales

    2018-03-01

    Full Text Available In this retrospective study 420 echocardiograms from a single center were reviewed showing that TAPSE was acquired in 66% while TA TDI s’ signals were recorded in 98% of all echocardiograms. Based on these results greater efforts are required to standardize acquisition and reporting of objective measurements of RV function. Keywords: Echocardiography, Right ventricular dysfunction, TAPSE, Tricuspid annulus, M-mode, Tissue doppler imaging

  6. Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study.

    Science.gov (United States)

    Unfer, Vittorio; Raffone, Emanuela; Rizzo, Piero; Buffo, Silvia

    2011-11-01

    Several factors can affect oocyte quality and therefore pregnancy outcome in assisted reproductive technology (ART) cycles. Recently, a number of studies have shown that the presence of several compounds in the follicular fluid positively correlates with oocyte quality and maturation (i.e., myo-inositol and melatonin). In the present study, we aim to evaluate the pregnancy outcomes after the administration of myo-inositol combined with melatonin in women who failed to conceive in previous in vitro fertilization (IVF) cycles due to poor oocyte quality. Forty-six women were treated with 4 g/day myo-inositol and 3 mg/day melatonin (inofolic® and inofolic® Plus, Lo.Lipharma, Rome) for 3 months and then underwent a new IVF cycle. After treatment, the number of mature oocytes, the fertilization rate, the number of both, total and top-quality embryos transferred were statistically higher compared to the previous IVF cycle, while there was no difference in the number of retrieved oocyte. After treatment, a total of 13 pregnancies occurred, 9 of them were confirmed echographically; four evolved in spontaneous abortion. The treatment with myo-inositol and melatonin improves ovarian stimulation protocols and pregnancy outcomes in infertile women with poor oocyte quality.

  7. Fashion Objects

    DEFF Research Database (Denmark)

    Andersen, Bjørn Schiermer

    2009-01-01

    -- an outline which at the same time indicates the need for transformations of the Durkheimian model on decisive points. Thus, thirdly, it returns to Durkheim and undertakes to develop his concepts in a direction suitable for a sociological theory of fashion. Finally, it discusses the theoretical implications......This article attempts to create a framework for understanding modern fashion phenomena on the basis of Durkheim's sociology of religion. It focuses on Durkheim's conception of the relation between the cult and the sacred object, on his notion of 'exteriorisation', and on his theory of the social...... symbol in an attempt to describe the peculiar attraction of the fashion object and its social constitution. However, Durkheim's notions of cult and ritual must undergo profound changes if they are to be used in an analysis of fashion. The article tries to expand the Durkheimian cult, radically enlarging...

  8. Utilities objectives

    International Nuclear Information System (INIS)

    Cousin, Y.; Fabian, H.U.

    1996-01-01

    The policy of French and german utilities is to make use of nuclear energy as a long term, competitive and environmentally friendly power supply. The world electricity generation is due to double within the next 30 years. In the next 20 to 30 years the necessity of nuclear energy will be broadly recognized. More than for most industries, to deal properly with nuclear energy requires the combination of a consistent political will, of a proper institutional framework, of strong and legitimate control authorities, of a sophisticated industry and of operators with skilled management and human resources. One of the major risk facing nuclear energy is the loss of competitiveness. This can be achieved only through the combination of an optimized design, a consistent standardization, a proper industrial partnership and a stable long term strategy. Although the existing plants in Western Europe are already very safe, the policy is clearly to enhance the safety of the next generation of nuclear plants which are designing today. The French and German utilities have chosen an evolutionary approach based on experience and proven technologies, with an enhanced defense in depth and an objective of easier operation and maintenance. The cost objective is to maintain and improve what has been achieved in the best existing power plants in both countries. This calls for rational choices and optimized design to meet the safety objectives, a strong standardization policy, short construction times, high availability and enough flexibility to enable optimization of the fuel cycle throughout the lifetime of the plants. The conceptual design phase has proven that the French and German teams from industry and from the utilities are able to pursue both the safety and the cost objectives, basing their decision on a rational approach which could be accepted by the safety authorities. (J.S.)

  9. Quasi-objects, Cult Objects and Fashion Objects

    DEFF Research Database (Denmark)

    Andersen, Bjørn Schiermer

    2011-01-01

    This article attempts to rehabilitate the concept of fetishism and to contribute to the debate on the social role of objects as well as to fashion theory. Extrapolating from Michel Serres’ theory of the quasi-objects, I distinguish two phenomenologies possessing almost opposite characteristics. T...... as a unique opportunity for studying the interchange between these two forms of fetishism and their respective phenomenologies. Finally, returning to Serres, I briefly consider the theoretical consequences of introducing the fashion object as a quasi-object.......This article attempts to rehabilitate the concept of fetishism and to contribute to the debate on the social role of objects as well as to fashion theory. Extrapolating from Michel Serres’ theory of the quasi-objects, I distinguish two phenomenologies possessing almost opposite characteristics....... These two phenomenologies are, so I argue, essential to quasi-object theory, yet largely ignored by Serres’ sociological interpreters. They correspond with the two different theories of fetishism found in Marx and Durkheim, respectively. In the second half of the article, I introduce the fashion object...

  10. Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study.

    Science.gov (United States)

    Chanan-Khan, Asher; Cramer, Paula; Demirkan, Fatih; Fraser, Graeme; Silva, Rodrigo Santucci; Grosicki, Sebastian; Pristupa, Aleksander; Janssens, Ann; Mayer, Jiri; Bartlett, Nancy L; Dilhuydy, Marie-Sarah; Pylypenko, Halyna; Loscertales, Javier; Avigdor, Abraham; Rule, Simon; Villa, Diego; Samoilova, Olga; Panagiotidis, Panagiots; Goy, Andre; Mato, Anthony; Pavlovsky, Miguel A; Karlsson, Claes; Mahler, Michelle; Salman, Mariya; Sun, Steven; Phelps, Charles; Balasubramanian, Sriram; Howes, Angela; Hallek, Michael

    2016-02-01

    Most patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma relapse after initial therapy. Bendamustine plus rituximab is often used in the relapsed or refractory setting. We assessed the efficacy and safety of adding ibrutinib, an oral covalent inhibitor of Bruton's tyrosine kinase (BTK), to bendamustine plus rituximab in patients with previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma. The HELIOS trial was an international, double-blind, placebo-controlled, phase 3 study in adult patients (≥18 years of age) who had active chronic lymphocytic leukaemia or small lymphocytic lymphoma with measurable lymph node disease (>1·5 cm) by CT scan, and had relapsed or refractory disease following one or more previous lines of systemic therapy consisting of at least two cycles of a chemotherapy-containing regimen, an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1, and adequate bone marrow, liver, and kidney function. Patients with del(17p) were excluded because of known poor response to bendamustine plus rituximab. Patients who had received previous treatment with ibrutinib or other BTK inhibitors, refractory disease or relapse within 24 months with a previous bendamustine-containing regimen, or haemopoietic stem-cell transplant were also excluded. Patients were randomly assigned (1:1) by a web-based system to receive bendamustine plus rituximab given in cycles of 4 weeks' duration (bendamustine: 70 mg/m(2) intravenously on days 2-3 in cycle 1, and days 1-2 in cycles 2-6; rituximab: 375 mg/m(2) on day 1 of cycle 1, and 500 mg/m(2) on day 1 of cycles 2-6 for a maximum of six cycles) with either ibrutinib (420 mg daily orally) or placebo until disease progression or unacceptable toxicity. Patients were stratified according to whether they were refractory to purine analogues and by number of previous lines of therapy. The primary endpoint was independent review committee (IRC)-assessed progression

  11. Sensitivity Analysis of Multi-objective Optimization for Solid Waste Management: A Case Study of Dar es Salaam, Tanzania

    Directory of Open Access Journals (Sweden)

    Halidi Lyeme

    2017-11-01

    Full Text Available In this study, a sensitivity analysis of a multi-objective optimization model for solid waste management (SWM for Dar es Salaam city in Tanzania is considered. Our objectives were to identify the most sensitive parameters and effect of other input data to the model output. Five scenarios were considered by varying their associated parameter values. The results showed that the decrease of total cost for the SWM system in all scenarios was observed compared to the baseline solution when the single landfill was considered. Furthermore, the analysis shows that the variable cost parameter for the processing facilities is very sensitivity in such a way that if you increase the variable cost then, there is a rapid increase of total cost for the SWM system and the vice versa is true. The relevant suggestions to the decision makers were also discussed.

  12. Is objectively measured sitting at work associated with low-back pain? A cross sectional study in the DPhacto cohort.

    Science.gov (United States)

    Korshøj, Mette; Hallman, David M; Mathiassen, Svend Erik; Aadahl, Mette; Holtermann, Andreas; Jørgensen, Marie Birk

    2018-01-01

    Objectives Low-back pain (LBP) is a substantial health challenge due to the risk for long-term sickness absence and early retirement. Several biomechanical exposures at work, including sitting, have been suggested to increase the risk for LBP. The objectives of this study were to determine (i) the extent to which temporal patterns and total amount of objectively measured sitting is associated with LBP intensity and (ii) whether selected modifiers influence these associations. Methods This cross sectional study uses baseline data from the Danish PHysical ACTivity cohort with Objective measurements (DPhacto) of physical activities in the cleaning, transport and manufacturing sectors. Peak intensity of LBP was collected by questionnaire on a 0-10 scale and sitting was expressed in terms of total duration and temporal pattern, ie, time spent in brief bursts (≤5 minutes), moderate periods (>5-≤20 minutes), and prolonged periods of sitting (>20 minutes); both during work and whole day (waking hours only). Associations were determined using linear regression in models accounting for moderation and confounding. Factors evaluated as moderators or confounders were assessed by questionnaire. Results The population consisted of 704 participants. No significant associations were found between total duration or temporal patterns of sitting and LBP intensity, neither during work nor for the whole day. Body mass index (BMI) significantly moderated the association between sitting and LBP; participants with a high and low BMI showing a negative and positive association, respectively. Conclusion Sitting was not independently associated with peak LBP intensity, suggesting other exposures are more powerful risk factors for LBP.

  13. Using the genome aggregation database, computational pathogenicity prediction tools, and patch clamp heterologous expression studies to demote previously published long QT syndrome type 1 mutations from pathogenic to benign.

    Science.gov (United States)

    Clemens, Daniel J; Lentino, Anne R; Kapplinger, Jamie D; Ye, Dan; Zhou, Wei; Tester, David J; Ackerman, Michael J

    2018-04-01

    Mutations in the KCNQ1-encoded Kv7.1 potassium channel cause long QT syndrome (LQTS) type 1 (LQT1). It has been suggested that ∼10%-20% of rare LQTS case-derived variants in the literature may have been published erroneously as LQT1-causative mutations and may be "false positives." The purpose of this study was to determine which previously published KCNQ1 case variants are likely false positives. A list of all published, case-derived KCNQ1 missense variants (MVs) was compiled. The occurrence of each MV within the Genome Aggregation Database (gnomAD) was assessed. Eight in silico tools were used to predict each variant's pathogenicity. Case-derived variants that were either (1) too frequently found in gnomAD or (2) absent in gnomAD but predicted to be pathogenic by ≤2 tools were considered potential false positives. Three of these variants were characterized functionally using whole-cell patch clamp technique. Overall, there were 244 KCNQ1 case-derived MVs. Of these, 29 (12%) were seen in ≥10 individuals in gnomAD and are demotable. However, 157 of 244 MVs (64%) were absent in gnomAD. Of these, 7 (4%) were predicted to be pathogenic by ≤2 tools, 3 of which we characterized functionally. There was no significant difference in current density between heterozygous KCNQ1-F127L, -P477L, or -L619M variant-containing channels compared to KCNQ1-WT. This study offers preliminary evidence for the demotion of 32 (13%) previously published LQT1 MVs. Of these, 29 were demoted because of their frequent sighting in gnomAD. Additionally, in silico analysis and in vitro functional studies have facilitated the demotion of 3 ultra-rare MVs (F127L, P477L, L619M). Copyright © 2017 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

  14. Synthesis of optical holograms of rotating objects

    International Nuclear Information System (INIS)

    Bogdanova, T.V.; Titar', V.P.; Tomchuk, E.Ya.

    1998-01-01

    A method of synthesis of rotating objects is analyzed and its advantages over the previously known methods and restrictions caused by the nonlinear character of motion of objects being studied are determined. Numerical simulation is used to study properties of synthesized holograms and the images reconstructed with their help. The resolving power of synthesized holograms is determined. The pulsed response of the system used for the synthesis of rotating objects is studied and its isoplanar sections are determined. It is shown that in the optical range, in contrast to the radio-frequency range, one can synthesize holograms and reconstruct visual images not only of rotating objects, but of vibrating objects as well. For small angles of object rotation (0.0025 rad), an image with a high resolution power (0.0004 m) can be obtained

  15. Object-based change detection in rapid urbanization regions with remotely sensed observations: a case study of Shenzhen, China

    Science.gov (United States)

    He, Lihuang; Dong, Guihua; Wang, Wei-Min; Yang, Lijun; Liang, Hong

    2013-10-01

    China, the most populous country on Earth, has experienced rapid urbanization which is one of the main causes of many environmental and ecological problems. Therefore, the monitoring of rapid urbanization regions and the environment is of critical importance for their sustainable development. In this study, the object-based classification is employed to detect the change of land cover in Shenzhen, which is located in South China and has been urbanized rapidly in recent three decades. First, four Landsat TM images, which were acquired on 1990, 2000 and 2010, respectively, are selected from the image database. Atmospheric corrections are conducted on these images with improved dark-object subtraction technique and surface meteorological observations. Geometric correction is processed with ground control points derived from topographic maps. Second, a region growing multi-resolution segmentation and a soft nearest neighbour classifier are used to finish object-based classification. After analyzing the fraction of difference classes over time series, we conclude that the comparison of derived land cover classes with socio-economic statistics demonstrates the strong positive correlation between built-up classes and urban population as well as gross GDP and GDPs in second and tertiary industries. Two different mechanisms of urbanization, namely new land development and redevelopment, are revealed. Consequently, we found that, the districts of Shenzhen were urbanized through different mechanisms.

  16. Neural processes underlying the"same"-"different" judgment of two simultaneously presented objects--an EEG study.

    Directory of Open Access Journals (Sweden)

    Ruiling Zhang

    Full Text Available The present study investigated the neural processes underlying "same" and -"different" judgments for two simultaneously presented objects, that varied on one or both, of two dimensions: color and shape. Participants judged whether or not the two objects were "same" or "different" on either the color dimension (color task or the shape dimension (shape task. The unattended irrelevant dimension of the objects was either congruent (same-same; different-different or incongruent (same-different. ERP data showed a main effect of color congruency in the time window 190-260 ms post-stimulus presentation and a main effect of shape congruency in the time window 220-280 ms post-stimulus presentation in both color and shape tasks. The interaction between color and shape congruency in the ERP data occurred in a later time window than the two main effects, indicating that mismatches in task-relevant and task-irrelevant dimensions were processed automatically and independently before a response was selected. The fact that the interference of the task-irrelevant dimension occurred after mismatch detection, supports a confluence model of processing.

  17. Brain dynamics of upstream perceptual processes leading to visual object recognition: a high density ERP topographic mapping study.

    Science.gov (United States)

    Schettino, Antonio; Loeys, Tom; Delplanque, Sylvain; Pourtois, Gilles

    2011-04-01

    Recent studies suggest that visual object recognition is a proactive process through which perceptual evidence accumulates over time before a decision can be made about the object. However, the exact electrophysiological correlates and time-course of this complex process remain unclear. In addition, the potential influence of emotion on this process has not been investigated yet. We recorded high density EEG in healthy adult participants performing a novel perceptual recognition task. For each trial, an initial blurred visual scene was first shown, before the actual content of the stimulus was gradually revealed by progressively adding diagnostic high spatial frequency information. Participants were asked to stop this stimulus sequence as soon as they could correctly perform an animacy judgment task. Behavioral results showed that participants reliably gathered perceptual evidence before recognition. Furthermore, prolonged exploration times were observed for pleasant, relative to either neutral or unpleasant scenes. ERP results showed distinct effects starting at 280 ms post-stimulus onset in distant brain regions during stimulus processing, mainly characterized by: (i) a monotonic accumulation of evidence, involving regions of the posterior cingulate cortex/parahippocampal gyrus, and (ii) true categorical recognition effects in medial frontal regions, including the dorsal anterior cingulate cortex. These findings provide evidence for the early involvement, following stimulus onset, of non-overlapping brain networks during proactive processes eventually leading to visual object recognition. Copyright © 2011 Elsevier Inc. All rights reserved.

  18. Incidence of Acneform Lesions in Previously Chemically Damaged Persons-2004

    Directory of Open Access Journals (Sweden)

    N Dabiri

    2008-04-01

    Full Text Available ABSTRACT: Introduction & Objective: Chemical gas weapons especially nitrogen mustard which was used in Iraq-Iran war against Iranian troops have several harmful effects on skin. Some other chemical agents also can cause acne form lesions on skin. The purpose of this study was to compare the incidence of acneform in previously chemically damaged soldiers and non chemically damaged persons. Materials & Methods: In this descriptive and analytical study, 180 chemically damaged soldiers, who have been referred to dermatology clinic between 2000 – 2004, and forty non-chemically damaged people, were chosen randomly and examined for acneform lesions. SPSS software was used for statistic analysis of the data. Results: The mean age of the experimental group was 37.5 ± 5.2 and that of the control group was 38.7 ± 5.9 years. The mean percentage of chemical damage in cases was 31 percent and the time after the chemical damage was 15.2 ± 1.1 years. Ninety seven cases (53.9 percent of the subjects and 19 people (47.5 percent of the control group had some degree of acne. No significant correlation was found in incidence, degree of lesions, site of lesions and age of subjects between two groups. No significant correlation was noted between percentage of chemical damage and incidence and degree of lesions in case group. Conclusion: Incidence of acneform lesions among previously chemically injured peoples was not higher than the normal cases.

  19. An external proton beam at VERA to study objects of art by proton induced x-ray emission (PIXE)

    International Nuclear Information System (INIS)

    Kroepfl, P.; Forstner, O.; Kutschera, W.; Priller, A.; Steier, P.; Wallner, A.; Wuenschek, B.; Golser, R.

    2006-01-01

    Full text: PIXE is a very sensitive analytical method to determine the chemical composition of art objects, e.g. drawings, handwritings etc. A particular advantage is the possibility to analyze objects non-destructively under atmospheric pressure. Such an external beam PIXE facility is currently implemented at the Vienna Environmental Research Accelerator (VERA). The set-up allows to extract a 3 MeV proton beam of approximately 100 μm in diameter and currents in the range of a few nA's through an ultra-thin (0.1 μm) Silicon Nitride window. The characteristic x-rays emitted from the specimen are recorded with a Si(Li) and a Silicon Drift detector simultaneously to cover the widest possible Z-range of the detected elements. We have just completed an extensive period of studying beam effects on ancient paper to exclude possible damage to art objects, in particular drawings of the Renaissance that are among the most precious and rarest treasuries of graphical collections. They were created with different materials such as inks, chalks and metal points. A large collection of these fine arts objects is situated at the Albertina in Vienna. Together with scientists from the Centre de Recherche et de Restauration des Musees de France (C2RMF) in Paris, I. Reiche, A. Duval, H. Guicharnaud, from the CEREGE UMR CNRS 6635 in Aix-en-Provence, S. Merchel, from the Albertina in Vienna, E. Thobois, H. Singer, and from the Akademie der bildenden Kuenste in Vienna, M. Schreiner, we want then to analyze a few selected silverpoint drawings by Albrecht Duerer (1471-1528). (author)

  20. The development of multi-objective optimization model for excess bagasse utilization: A case study for Thailand

    International Nuclear Information System (INIS)

    Buddadee, Bancha; Wirojanagud, Wanpen; Watts, Daniel J.; Pitakaso, Rapeepan

    2008-01-01

    In this paper, a multi-objective optimization model is proposed as a tool to assist in deciding for the proper utilization scheme of excess bagasse produced in sugarcane industry. Two major scenarios for excess bagasse utilization are considered in the optimization. The first scenario is the typical situation when excess bagasse is used for the onsite electricity production. In case of the second scenario, excess bagasse is processed for the offsite ethanol production. Then the ethanol is blended with an octane rating of 91 gasoline by a portion of 10% and 90% by volume respectively and the mixture is used as alternative fuel for gasoline vehicles in Thailand. The model proposed in this paper called 'Environmental System Optimization' comprises the life cycle impact assessment of global warming potential (GWP) and the associated cost followed by the multi-objective optimization which facilitates in finding out the optimal proportion of the excess bagasse processed in each scenario. Basic mathematical expressions for indicating the GWP and cost of the entire process of excess bagasse utilization are taken into account in the model formulation and optimization. The outcome of this study is the methodology developed for decision-making concerning the excess bagasse utilization available in Thailand in view of the GWP and economic effects. A demonstration example is presented to illustrate the advantage of the methodology which may be used by the policy maker. The methodology developed is successfully performed to satisfy both environmental and economic objectives over the whole life cycle of the system. It is shown in the demonstration example that the first scenario results in positive GWP while the second scenario results in negative GWP. The combination of these two scenario results in positive or negative GWP depending on the preference of the weighting given to each objective. The results on economics of all scenarios show the satisfied outcomes

  1. Diurnal rhythm and concordance between objective and subjective hot flashes: The Hilo Women’s Health Study

    Science.gov (United States)

    Sievert, Lynnette L.; Reza, Angela; Mills, Phoebe; Morrison, Lynn; Rahberg, Nichole; Goodloe, Amber; Sutherland, Michael; Brown, Daniel E.

    2010-01-01

    Objective To test for a diurnal pattern in hot flashes in a multi-ethnic population living in a hot, humid environment. To examine rates of concordance between objective and subjective measures of hot flashes using ambulatory and laboratory measures. Methods Study participants aged 45–55 were recruited from the general population of Hilo, Hawaii. Women wore a Biolog hot flash monitor, kept a diary for 24-hours, and also participated in 3-hour laboratory measures (n=199). Diurnal patterns were assessed using polynomial regression. For each woman, objectively recorded hot flashes that matched subjective experience were treated as true positive readings. Subjective hot flashes were considered the standard for computing false positive and false negative readings. True positive, false positive, and false negative readings were compared across ethnic groups by chi-square analyses. Results Frequencies of sternal, nuchal and subjective hot flashes peaked at 15:00 ± 1 hour with no difference by ethnicity. Laboratory results supported the pattern seen in ambulatory monitoring. Sternal and nuchal monitoring showed the same frequency of true positive measures, but non-sternal electrodes picked up more false positive readings. Laboratory monitoring showed very low frequencies of false negatives. There were no ethnic differences in the frequency of true positive or false positive measures. Women of European descent were more likely to report hot flashes that were not objectively demonstrated (false negative measures). Conclusions The diurnal pattern and peak in hot flash occurrence in the hot humid environment of Hilo was similar to results from more temperate environments. Lack of variation in sternal vs. non-sternal measures, and in true positive measures across ethnicities suggests no appreciable effect of population variation in sweating patterns. PMID:20220538

  2. Recent and future developments in the use of radiation for the study of objects of cultural heritage significance

    International Nuclear Information System (INIS)

    Creagh, Dudley; Lee, Alana; Otieno-Alego, Vincent; Kubik, Maria

    2009-01-01

    Until recently, items of cultural heritage significance have been studied only using laboratory-based techniques. Improvements in the design of synchrotron radiation sources have made it possible to undertake experiments on objects of cultural heritage experience which had hitherto been impossible. Experimental techniques used in conservation science studies range from infrared microscopy to X-ray diffraction and fluorescence (both micro- and macro-diffraction), to small and wide angle X-ray scattering (SAXS/WAXS) (both micro- and macro-scattering). Here, we describe studies of important artefacts held by Australian national collecting agencies using both laboratory- and synchrotron-based analytical techniques and particle beam X-ray emission (PIXE). As well, a new technique for studying easel paintings, hyperspectral imaging, will be introduced.

  3. Objects in Motion

    Science.gov (United States)

    Damonte, Kathleen

    2004-01-01

    One thing scientists study is how objects move. A famous scientist named Sir Isaac Newton (1642-1727) spent a lot of time observing objects in motion and came up with three laws that describe how things move. This explanation only deals with the first of his three laws of motion. Newton's First Law of Motion says that moving objects will continue…

  4. Comparisons of Objective Sleep Quality Between Elderly Individuals With and Without Cataract Surgery: A Cross-Sectional Study of the HEIJO-KYO Cohort

    Directory of Open Access Journals (Sweden)

    Kenji Obayashi

    2015-08-01

    Full Text Available Background: Cataract surgery (CS drastically increases the capacity for light reception to the retina. Several previous studies have suggested the beneficial effect of CS on subjectively measured sleep quality; however, the association between CS and objectively measured sleep quality remains uncertain. Methods: To evaluate the association between CS and objectively measured sleep quality in home settings, we conducted a cross-sectional study in 1037 elderly individuals (mean age, 71.9 years. We evaluated actigraphically measured sleep quality, urinary 6-sulfatoxymelatonin excretion, and ambulatory light levels, in addition to CS status. Results: The CS group (n = 174 showed significantly higher sleep efficiency and shorter wake after sleep onset than the no CS group (n = 863, even after adjustment for age, gender, body mass index, current smoking status, alcohol consumption, hypertension, diabetes, sleep medication, bedtime, rising time, daytime physical activity, daytime and nighttime light exposure, and urinary 6-sulfatoxymelatonin excretion (sleep efficiency: 85.8% in the CS group vs 84.4% in the no CS group, P = 0.042; wake after sleep onset: 45.7 min vs 50.6 min, respectively, P = 0.033. In contrast, urinary 6-sulfatoxymelatonin excretion, sleep onset latency, total sleep time, and sleep-mid time did not differ significantly between the CS and no CS groups. Conclusions: Among a community-dwelling elderly population, CS is significantly associated with objectively measured sleep quality, but urinary levels of melatonin metabolite do not differ between individuals with and without CS. These associations are independent of daily light exposure profiles.

  5. Measurement errors in polymerase chain reaction are a confounding factor for a correct interpretation of 5-HTTLPR polymorphism effects on lifelong premature ejaculation: a critical analysis of a previously published meta-analysis of six studies.

    Directory of Open Access Journals (Sweden)

    Paddy K C Janssen

    Full Text Available OBJECTIVE: To analyze a recently published meta-analysis of six studies on 5-HTTLPR polymorphism and lifelong premature ejaculation (PE. METHODS: Calculation of fraction observed and expected genotype frequencies and Hardy Weinberg equilibrium (HWE of cases and controls. LL,SL and SS genotype frequencies of patients were subtracted from genotype frequencies of an ideal population (LL25%, SL50%, SS25%, p = 1 for HWE. Analysis of PCRs of six studies and re-analysis of the analysis and Odds ratios (ORs reported in the recently published meta-analysis. RESULTS: Three studies deviated from HWE in patients and one study deviated from HWE in controls. In three studies in-HWE the mean deviation of genotype frequencies from a theoretical population not-deviating from HWE was small: LL(1.7%, SL(-2.3%, SS(0.6%. In three studies not-in-HWE the mean deviation of genotype frequencies was high: LL(-3.3%, SL(-18.5% and SS(21.8% with very low percentage SL genotype concurrent with very high percentage SS genotype. The most serious PCR deviations were reported in the three not-in-HWE studies. The three in-HWE studies had normal OR. In contrast, the three not-in-HWE studies had a low OR. CONCLUSIONS: In three studies not-in-HWE and with very low OR, inadequate PCR analysis and/or inadequate interpretation of its gel electrophoresis resulted in very low SL and a resulting shift to very high SS genotype frequency outcome. Consequently, PCRs of these three studies are not reliable. Failure to note the inadequacy of PCR tests makes such PCRs a confounding factor in clinical interpretation of genetic studies. Currently, a meta-analysis can only be performed on three studies-in-HWE. However, based on the three studies-in-HWE with OR of about 1 there is not any indication that in men with lifelong PE the frequency of LL,SL and SS genotype deviates from the general male population and/or that the SL or SS genotype is in any way associated with lifelong PE.

  6. Distributed and hierarchical object-based image analysis for damage assessment: a case study of 2008 Wenchuan earthquake, China

    Directory of Open Access Journals (Sweden)

    Jing Sun

    2016-11-01

    Full Text Available Object-based image analysis (OBIA is an emerging technique for analyzing remote sensing image based on object properties including spectral, geometry, contextual and texture information. To reduce the computational cost of this comprehensive OBIA and make it more feasible in disaster responses, we developed a unique approach – distributed and hierarchical OBIA approach for damage assessment. This study demonstrated a completed classification of YingXiu town, heavily devastated by the 2008 Wenchuan earthquake using Quickbrid imagery. Two distinctive areas, mountainous areas and urban, were analyzed separately. This approach does not require substantial processing power and large amounts of available memory because image of a large disaster-affected area was split in smaller pieces. Two or more computers could be used in parallel to process and analyze these sub-images based on different requirements. The approach can be applicable in other cases whereas the established set of rules can be adopted in similar study areas. More experiments will be carried out in future studies to prove its feasibility.

  7. Which surgery should be offered for carpal tunnel syndrome in a patient who was previously treated for recurrence on the contralateral side? Preliminary study of 13 patients with the Canaletto® implant.

    Science.gov (United States)

    Illuminati, I; Seigle-Murandi, F; Gouzou, S; Fabacher, T; Facca, S; Hidalgo Diaz, J J; Liverneaux, P

    2017-12-01

    There are no published studies on the management of carpal tunnel syndrome (CTS) patients who have already been operated for recurrent CTS on the contralateral side. The aim of this study was to evaluate 13 patients with CTS who underwent primary release using a Canaletto ® implant. The 13 patients had all been operated for recurrent CTS previously. On the contralateral side, they all had subjective signs, and two of them already had complications. All were operated with the Canaletto ® implant according to Duché's technique, in a mean of 20minutes. After a mean 19.3-month follow-up, paresthesia, pain, and QuickDASH scores were significantly improved, even in one patient who underwent revision at another facility. This preliminary study suggests that use of a Canaletto ® implant as first-line treatment for CTS in patients who already underwent revision surgery on the other side is a simple and safe technique, without worsening of symptoms. These findings should be assessed with a prospective randomized controlled trial. Copyright © 2017 SFCM. Published by Elsevier Masson SAS. All rights reserved.

  8. Planetcam: A Visible And Near Infrared Lucky-imaging Camera To Study Planetary Atmospheres And Solar System Objects

    Science.gov (United States)

    Sanchez-Lavega, Agustin; Rojas, J.; Hueso, R.; Perez-Hoyos, S.; de Bilbao, L.; Murga, G.; Ariño, J.; Mendikoa, I.

    2012-10-01

    PlanetCam is a two-channel fast-acquisition and low-noise camera designed for a multispectral study of the atmospheres of the planets (Venus, Mars, Jupiter, Saturn, Uranus and Neptune) and the satellite Titan at high temporal and spatial resolutions simultaneously invisible (0.4-1 μm) and NIR (1-2.5 μm) channels. This is accomplished by means of a dichroic beam splitter that separates both beams directing them into two different detectors. Each detector has filter wheels corresponding to the characteristic absorption bands of each planetary atmosphere. Images are acquired and processed using the “lucky imaging” technique in which several thousand images of the same object are obtained in a short time interval, coregistered and ordered in terms of image quality to reconstruct a high-resolution ideally diffraction limited image of the object. Those images will be also calibrated in terms of intensity and absolute reflectivity. The camera will be tested at the 50.2 cm telescope of the Aula EspaZio Gela (Bilbao) and then commissioned at the 1.05 m at Pic-duMidi Observatory (Franca) and at the 1.23 m telescope at Calar Alto Observatory in Spain. Among the initially planned research targets are: (1) The vertical structure of the clouds and hazes in the planets and their scales of variability; (2) The meteorology, dynamics and global winds and their scales of variability in the planets. PlanetCam is also expected to perform studies of other Solar System and astrophysical objects. Acknowledgments: This work was supported by the Spanish MICIIN project AYA2009-10701 with FEDER funds, by Grupos Gobierno Vasco IT-464-07 and by Universidad País Vasco UPV/EHU through program UFI11/55.

  9. Usefulness of indirect alcohol biomarkers for predicting recidivism of drunk-driving among previously convicted drunk-driving offenders: results from the recidivism of alcohol-impaired driving (ROAD) study.

    Science.gov (United States)

    Maenhout, Thomas M; Poll, Anneleen; Vermassen, Tijl; De Buyzere, Marc L; Delanghe, Joris R

    2014-01-01

    In several European countries, drivers under the influence (DUI), suspected of chronic alcohol abuse are referred for medical and psychological examination. This study (the ROAD study, or Recidivism Of Alcohol-impaired Driving) investigated the usefulness of indirect alcohol biomarkers for predicting drunk-driving recidivism in previously convicted drunk-driving offenders. The ROAD study is a prospective study (2009-13) that was performed on 517 randomly selected drivers in Belgium. They were convicted for drunk-driving for which their licence was confiscated. The initial post-arrest blood samples were collected and analysed for percentage carbohydrate-deficient transferrin (%CDT), transaminsase activities [alanine amino transferase (ALT), aspartate amino transferase (AST)], gamma-glutamyltransferase (γGT) and red cell mean corpuscular volume (MCV). The observation time for each driver was 3 years and dynamic. A logistic regression analysis revealed that ln(%CDT) (P drunk-driving. The ROAD index (which includes ln(%CDT), ln(γGT), -ln(ALT) and the sex of the driver) was calculated and had a significantly higher area under the receiver operator characteristic curve (0.71) than the individual biomarkers for drunk-driving recidivism. Drivers with a high risk of recidivating (ROAD index ≥ 25%; third tertile) could be distinguished from drivers with an intermediate risk (16% ≤ ROAD index drunk-driving. The association with gamma-glutamyltransferase, alanine amino transferase and the sex of the driver could have additional value for identifying drunk-drivers at intermediate risk of recidivism. Non-specific indirect alcohol markers, such as alanine amino transferase, gamma-glutamyltransferase, aspartate amino transferase and red cell mean corpuscular volume have minimal added value to % carbohydrate-deficient transferrin for distinguishing drunk drivers with a low or high risk of recidivism. © 2013 Society for the Study of Addiction.

  10. LibHalfSpace: A C++ object-oriented library to study deformation and stress in elastic half-spaces

    Science.gov (United States)

    Ferrari, Claudio; Bonafede, Maurizio; Belardinelli, Maria Elina

    2016-11-01

    The study of deformation processes in elastic half-spaces is widely employed for many purposes (e.g. didactic, scientific investigation of real processes, inversion of geodetic data, etc.). We present a coherent programming interface containing a set of tools designed to make easier and faster the study of processes in an elastic half-space. LibHalfSpace is presented in the form of an object-oriented library. A set of well known and frequently used source models (Mogi source, penny shaped horizontal crack, inflating spheroid, Okada rectangular dislocation, etc.) are implemented to describe the potential usage and the versatility of the library. The common interface given to library tools enables us to switch easily among the effects produced by different deformation sources that can be monitored at the free surface. Furthermore, the library also offers an interface which simplifies the creation of new source models exploiting the features of object-oriented programming (OOP). These source models can be built as distributions of rectangular boundary elements. In order to better explain how new models can be deployed some examples are included in the library.

  11. A study of the image quality of computed tomography adaptive statistical iterative reconstructed brain images using subjective and objective methods

    International Nuclear Information System (INIS)

    Mangat, J.; Morgan, J.; Benson, E.; Baath, M.; Lewis, M.; Reilly, A.

    2016-01-01

    The recent reintroduction of iterative reconstruction in computed tomography has facilitated the realisation of major dose saving. The aim of this article was to investigate the possibility of achieving further savings at a site with well-established Adaptive Statistical iterative Reconstruction (ASiR TM ) (GE Healthcare) brain protocols. An adult patient study was conducted with observers making visual grading assessments using image quality criteria, which were compared with the frequency domain metrics, noise power spectrum and modulation transfer function. Subjective image quality equivalency was found in the 40-70% ASiR TM range, leading to the proposal of ranges for the objective metrics defining acceptable image quality. Based on the findings of both the patient-based and objective studies of the ASiR TM /tube-current combinations tested, 60%/305 mA was found to fall within all, but one, of these ranges. Therefore, it is recommended that an ASiR TM level of 60%, with a noise index of 12.20, is a viable alternative to the currently used protocol featuring a 40% ASiR TM level and a noise index of 11.20, potentially representing a 16% dose saving. (authors)

  12. Predictive value of object relations for therapeutic alliance and outcome in psychotherapy for depression: an exploratory study.

    Science.gov (United States)

    Van, Henricus L; Hendriksen, Mariëlle; Schoevers, Robert A; Peen, Jaap; Abraham, Robert A; Dekker, Jack

    2008-09-01

    The concept of object relations has been shown to be relevant for the process and outcome of psychodynamic psychotherapies. However, little is known about its relevance for the psychotherapeutic treatment of depression. In this study, we explored the predictive value of object relational functioning (ORF) for the therapeutic alliance and outcome of short-term psychodynamic supportive psychotherapy in patients with mild to moderately severe depression. The ORF of 81 patients was rated by using the Developmental Profile. The overall maturity of ORF measured at baseline was higher in patients who showed a better treatment response. In multiple regression analysis, the adaptive level of individuation appeared to be specifically predictive of outcome. Patients with a recurrent depression showed less mature levels of ORF, lower adaptive levels and a higher score on the symbiotic level. No association was found between ORF and therapeutic alliance during treatment. In contrast to the single measure of alliance early in therapy, the growth of the alliance was related to outcome. The study indicated the relevance of ORF for depression and established that it is distinctive from the actual therapeutic alliance.

  13. Decoupling Object Detection and Categorization

    Science.gov (United States)

    Mack, Michael L.; Palmeri, Thomas J.

    2010-01-01

    We investigated whether there exists a behavioral dependency between object detection and categorization. Previous work (Grill-Spector & Kanwisher, 2005) suggests that object detection and basic-level categorization may be the very same perceptual mechanism: As objects are parsed from the background they are categorized at the basic level. In…

  14. Underestimation of Severity of Previous Whiplash Injuries

    Science.gov (United States)

    Naqui, SZH; Lovell, SJ; Lovell, ME

    2008-01-01

    INTRODUCTION We noted a report that more significant symptoms may be expressed after second whiplash injuries by a suggested cumulative effect, including degeneration. We wondered if patients were underestimating the severity of their earlier injury. PATIENTS AND METHODS We studied recent medicolegal reports, to assess subjects with a second whiplash injury. They had been asked whether their earlier injury was worse, the same or lesser in severity. RESULTS From the study cohort, 101 patients (87%) felt that they had fully recovered from their first injury and 15 (13%) had not. Seventy-six subjects considered their first injury of lesser severity, 24 worse and 16 the same. Of the 24 that felt the violence of their first accident was worse, only 8 had worse symptoms, and 16 felt their symptoms were mainly the same or less than their symptoms from their second injury. Statistical analysis of the data revealed that the proportion of those claiming a difference who said the previous injury was lesser was 76% (95% CI 66–84%). The observed proportion with a lesser injury was considerably higher than the 50% anticipated. CONCLUSIONS We feel that subjects may underestimate the severity of an earlier injury and associated symptoms. Reasons for this may include secondary gain rather than any proposed cumulative effect. PMID:18201501

  15. Previous exposure in a high-risk area for travellers' diarrhoea within the past year is associated with a significant protective effect for travellers' diarrhoea: a prospective observational cohort study in travellers to South Asia.

    Science.gov (United States)

    Kuenzli, Esther; Juergensen, David; Kling, Kerstin; Jaeger, Veronika K; DeCrom, Susan; Steffen, Robert; Widmer, Andreas F; Battegay, Manuel; Hatz, Christoph; Neumayr, Andreas

    2017-09-01

    Travellers' diarrhoea is the most common health problem in travellers. Depending on the region visited, up to 40% of travellers develop diarrhoea during a 2-week trip. The aim of this study was to assess risk factors for TD among travellers to the Indian subcontinent. An observational prospective multicentre cohort study investigated travellers to the Indian subcontinent. Participants completed questionnaires assessing the incidence of travellers' diarrhoea and identifying potential risk factors. Covariates were assessed univariately, followed by a multivariate regression. Two-hundred and twenty-six travellers were enrolled into the study, 178 filled in both pre- and post-travel questionnaires. Overall, the attack rate of travellers' diarrhoea was 38.2%. Travel destination is a key risk factor for the occurrence of TD. Travelling to India or Nepal vs Bhutan is associated with an increased risk for TD (OR 6.68 and 6.62, respectively). A length of stay of more than 3 weeks compared to less than 2 weeks is also associated with a significantly increased risk (OR 5.45). Having stayed in a high-risk area for travellers' diarrhoea within the past year before the current trip is associated with a significantly decreased risk (OR 0.19). No association was found between consumption of high risk food (i.e. tap water, ice cream, raw meat and hamburgers) and travellers' diarrhoea. Travellers' diarrhoea is a frequent problem in travellers to the Indian subcontinent. Previous exposure in a high-risk area for travellers' diarrhoea within the past year appears to have a significant protective effect. Furthermore, an association between the occurrence of travellers' diarrhoea and travel destination and length of stay, respectively, was observed. Consumption of risk food did not confer a TD risk in our study. © International Society of Travel Medicine, 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

  16. Myocardial adaption to HI(R)T in previously untrained men with a randomized, longitudinal cardiac MR imaging study (Physical adaptions in Untrained on Strength and Heart trial, PUSH-trial).

    Science.gov (United States)

    Scharf, Michael; Oezdemir, Derya; Schmid, Axel; Kemmler, Wolfgang; von Stengel, Simon; May, Matthias S; Uder, Michael; Lell, Michael M

    2017-01-01

    Although musculoskeletal effects in resistance training are well described, little is known about structural and functional cardiac adaption in formerly untrained subjects. We prospectively evaluated whether short term high intensity (resistance) training (HI(R)T) induces detectable morphologic cardiac changes in previously untrained men in a randomized controlled magnetic resonance imaging (MRI) study. 80 untrained middle-aged men were randomly assigned to a HI(R)T-group (n = 40; 43.5±5.9 years) or an inactive control group (n = 40; 42.0±6.3 years). HI(R)T comprised 22 weeks of training focusing on a single-set to failure protocol in 2-3 sessions/week, each with 10-13 exercises addressing main muscle groups. Repetitions were decreased from 8-10 to 3-5 during study period. Before and after HI(R)T all subjects underwent physiologic examination and cardiac MRI (cine imaging, tagging). Indexed left (LV) and right ventricular (RV) volume (LV: 76.8±15.6 to 78.7±14.8 ml/m2; RV: 77.0±15.5 to 78.7±15.1 ml/m2) and mass (LV: 55.5±9.7 to 57.0±8.8 g/m2; RV: 14.6±3.0 to 15.0±2.9 g/m2) significantly increased with HI(R)T (all pHI(R)T-group did not alter with training (0.73g/mL and 0.19g/mL, respectively [p = 0.96 and p = 0.87]), indicating balanced cardiac adaption. Indexed LV (48.4±11.1 to 50.8±11.0 ml/m2) and RV (48.5±11.0 to 50.6±10.7 ml/m2) stroke volume significantly increased with HI(R)T (pHI(R)T (36.2±7.9 to 37.0±8.4 ml/m2, p = 0.411), the ratio to end-diastolic LV volume at baseline and post-training was unchanged (0.47 vs. 0.47, p = 0.79). 22 weeks of HI(R)T lead to measurable, physiological changes in cardiac atrial and ventricular morphologic characteristics and function in previously untrained men. The PUSH-trial is registered at the US National Institutes of Health (ClinicalTrials.gov), NCT01766791.

  17. A multi-objective approach for optimal prioritization of energy efficiency measures in buildings: Model, software and case studies

    International Nuclear Information System (INIS)

    Karmellos, M.; Kiprakis, A.; Mavrotas, G.

    2015-01-01

    Highlights: • We provide a model for prioritization of energy efficiency measures in buildings. • We examine the case of a new building and one under renovation. • Objective functions are total primary energy consumption and total investment cost. • We provide a software tool that solves this multi-objective optimization problem. • Primary energy consumption and investment cost are inversely proportional. - Abstract: Buildings are responsible for some 40% of the total final energy consumption in the European Union and about 40% of the world’s primary energy consumption. Hence, the reduction of primary energy consumption is important for the overall energy chain. The scope of the current work is to assess the energy efficiency measures in the residential and small commercial sector and to develop a methodology and a software tool for their optimal prioritization. The criteria used for the prioritization of energy efficiency measures in this article are the primary energy consumption and the in