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Sample records for ob identifikatsii izomera

  1. Find an Ob-Gyn

    Science.gov (United States)

    ... Management Education & Events Advocacy For Patients About ACOG Find an Ob-Gyn Home About ACOG Find an Ob-Gyn Page Navigation ▼ About Us ACOG ... Districts ACOG Sections Careers at ACOG Contact Us Find an Ob-Gyn Search by State Search by ...

  2. Glucose metabolism and recycling by hepatocytes of OB/OB and ob/ob mice

    International Nuclear Information System (INIS)

    Lahtela, J.T.; Wals, P.A.; Katz, J.

    1990-01-01

    Hepatocytes were prepared from livers of ob/ob (obese diabetic) mice and their lean (OB/OB) siblings that had been fasted for 24 h. The hepatocytes were incubated with [U-14C, 2-3H]-, [U-14C, 3-3H]-, and [U-14C, 6-3H]glucose at concentrations from 20 to 120 mM. 14C was recovered mainly in CO2, glycogen, and lactate. Tritium was recovered in water and glycogen. The yield in labeled products from [2-3H]glucose ranged from two to three times that from [U-14C]glucose. The yields from [3-3H]- and [6-3H]glucose were similar, and 1.3-1.7 times that from [U-14C]glucose. At 40 mM, total utilization of glucose by obese mice was about twice that for lean mice, but there was little difference at 120 mM. The rate of recycling between glucose and glucose 6-phosphate was calculated. An equation to calculate the rate of recycling of glucose from the 2-3H/U-14C ratio in glycogen is derived in the APPENDIX. Our results show that (1) the utilization of glucose by hepatocytes from obese diabetic mice exceeds that of their lean controls, (2) the rate of glucose phosphorylation in both groups greatly exceeds glucose uptake and the rate of glycogen synthesis, (3) glucose phosphorylation represents a difference between a high glucokinase rate and hydrolysis of glucose 6-phosphate, and (4) recycling of glucose carbon between glucose 6-phosphate and pyruvate occurs within mouse hepatocytes

  3. Peripheral nervous system insulin resistance in ob/ob mice

    Science.gov (United States)

    2013-01-01

    Background A reduction in peripheral nervous system (PNS) insulin signaling is a proposed mechanism that may contribute to sensory neuron dysfunction and diabetic neuropathy. Neuronal insulin resistance is associated with several neurological disorders and recent evidence has indicated that dorsal root ganglion (DRG) neurons in primary culture display altered insulin signaling, yet in vivo results are lacking. Here, experiments were performed to test the hypothesis that the PNS of insulin-resistant mice displays altered insulin signal transduction in vivo. For these studies, nondiabetic control and type 2 diabetic ob/ob mice were challenged with an intrathecal injection of insulin or insulin-like growth factor 1 (IGF-1) and downstream signaling was evaluated in the DRG and sciatic nerve using Western blot analysis. Results The results indicate that insulin signaling abnormalities documented in other “insulin sensitive” tissues (i.e. muscle, fat, liver) of ob/ob mice are also present in the PNS. A robust increase in Akt activation was observed with insulin and IGF-1 stimulation in nondiabetic mice in both the sciatic nerve and DRG; however this response was blunted in both tissues from ob/ob mice. The results also suggest that upregulated JNK activation and reduced insulin receptor expression could be contributory mechanisms of PNS insulin resistance within sensory neurons. Conclusions These findings contribute to the growing body of evidence that alterations in insulin signaling occur in the PNS and may be a key factor in the pathogenesis of diabetic neuropathy. PMID:24252636

  4. Genetically obese (ob/ob) mice are resistant to the lethal effects of thioacetamide hepatotoxicity

    International Nuclear Information System (INIS)

    Won, Young-Suk; Song, Ji-Won; Lim, Jong-Hwan; Lee, Mee-Young; Moon, Og-Sung; Kim, Hyoung-Chin; Son, Hwa-Young; Kwon, Hyo-Jung

    2016-01-01

    Obesity increases the risk of chronic liver diseases, including viral hepatitis, alcohol-induced liver disease, and non-alcoholic steatohepatitis. In this study, we investigated the effects of obesity in acute hepatic failure using a murine model of thioacetamide (TA)-induced liver injury. Genetically obese ob/ob mice, together with non-obese ob/+ littermates, were subjected to a single intraperitoneal injection of TA, and examined for signs of hepatic injury. ob/ob mice showed a significantly higher survival rate, lower levels of serum alanine aminotransferase and aspartate aminotransferase, and less hepatic necrosis and apoptosis, compared with ob/+ mice. In addition, ob/ob mice exhibited significantly lower levels of malondialdehyde and significantly higher levels of glutathione and antioxidant enzyme activities compared with their ob/+ counterparts. Bioactivation analyses revealed reduced plasma clearance of TA and covalent binding of [ 14 C]TA to liver macromolecules in ob/ob mice. Together, these data demonstrate that genetically obese mice are resistant to TA-induced acute liver injury through diminished bioactivation of TA and antioxidant effects. - Highlights: • ob/ob mice are resistant to lethal doses of thioacetamide, compared to ob/+ mice. • ob/ob mice show reduced oxidative stress and enhanced antioxidant enzyme activity. • ob/ob mice exhibit diminished bioactivation of thioacetamide.

  5. Genetically obese (ob/ob) mice are resistant to the lethal effects of thioacetamide hepatotoxicity

    Energy Technology Data Exchange (ETDEWEB)

    Won, Young-Suk [Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk (Korea, Republic of); Song, Ji-Won [Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon (Korea, Republic of); Lim, Jong-Hwan [Huons Research Center, Gyonggido (Korea, Republic of); Lee, Mee-Young [Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine, Daejeon (Korea, Republic of); Moon, Og-Sung; Kim, Hyoung-Chin [Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk (Korea, Republic of); Son, Hwa-Young [Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon (Korea, Republic of); Kwon, Hyo-Jung, E-mail: hyojung@cnu.ac.kr [Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon (Korea, Republic of)

    2016-01-15

    Obesity increases the risk of chronic liver diseases, including viral hepatitis, alcohol-induced liver disease, and non-alcoholic steatohepatitis. In this study, we investigated the effects of obesity in acute hepatic failure using a murine model of thioacetamide (TA)-induced liver injury. Genetically obese ob/ob mice, together with non-obese ob/+ littermates, were subjected to a single intraperitoneal injection of TA, and examined for signs of hepatic injury. ob/ob mice showed a significantly higher survival rate, lower levels of serum alanine aminotransferase and aspartate aminotransferase, and less hepatic necrosis and apoptosis, compared with ob/+ mice. In addition, ob/ob mice exhibited significantly lower levels of malondialdehyde and significantly higher levels of glutathione and antioxidant enzyme activities compared with their ob/+ counterparts. Bioactivation analyses revealed reduced plasma clearance of TA and covalent binding of [{sup 14}C]TA to liver macromolecules in ob/ob mice. Together, these data demonstrate that genetically obese mice are resistant to TA-induced acute liver injury through diminished bioactivation of TA and antioxidant effects. - Highlights: • ob/ob mice are resistant to lethal doses of thioacetamide, compared to ob/+ mice. • ob/ob mice show reduced oxidative stress and enhanced antioxidant enzyme activity. • ob/ob mice exhibit diminished bioactivation of thioacetamide.

  6. Zinc metabolism in genetically obese (ob/ob) mice

    International Nuclear Information System (INIS)

    Kennedy, M.L.; Failla, M.L.

    1987-01-01

    Recent reports indicate that the concentrations and total amounts of several essential trace metals in various tissues of genetically obese rodents differ markedly from those in lean controls. In the present studies the absorption, retention and tissue distribution of zinc and constitutive levels of zinc-metallothionein (Zn-MT) in selected tissues were compared in obese (ob/ob) and lean (+/?) C57BL/6J mice. When 5-, 10- and 22-wk-old mice were administered 1.2 mumol 65 Zn by stomach tube the apparent absorption of 65 Zn by obese mice was 1.5, 2.2 and 3.9 times higher, respectively, than that in age-matched lean mice. Retention of orally administered 65 Zn after 96 h was also substantially higher in obese mice than in lean mice. To assess the possible influences of hyperphagia and intestinal hypertrophy on the enhanced apparent absorption of 65 Zn by obese mice food intake by an additional group of obese mice was restricted to that of age-matched lean controls. When actual absorption of zinc was determined according to the method of Heth and Hoekstra, groups of ad libitum--fed obese, pair-fed obese and lean mice absorbed 38, 32 and 18% of administered 65 Zn, respectively. In contrast, the rate of 65 Zn excretion 2-6 d after oral or subcutaneous administration of the metal was similar for obese and lean mice. Unrestricted and pair-fed obese mice had significantly lower percentages of carcass 65 Zn present in skin, muscle plus bone, spleen and testes and higher percentages present in liver, small intestine and adipose tissue than lean mice

  7. Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice

    Science.gov (United States)

    Sartori, Michelle; Conti, Filipe F.; Dias, Danielle da Silva; dos Santos, Fernando; Machi, Jacqueline F.; Palomino, Zaira; Casarini, Dulce E.; Rodrigues, Bruno; De Angelis, Kátia; Irigoyen, Maria-Claudia

    2017-01-01

    Objective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice. Methods: Metabolic parameters, cardiac function, arterial pressure (AP), autonomic, hormonal, inflammatory, and oxidative stress markers were evaluated in 12-weeks female wild-type (WT group) and ob/ob mice (OB group). Results: OB animals showed increased body weight, blood glucose, and triglyceride levels, along with glucose intolerance, when compared to WT animals. Ejection fraction (EF) and AP were similar between groups; however, the OB group presented diastolic dysfunction, as well as an impairment on myocardial performance index. Moreover, the OB group exhibited important autonomic dysfunction and baroreflex sensitivity impairment, when compared to WT group. OB group showed increased Angiotensin II levels in heart and renal tissues; decreased adiponectin and increased inflammatory markers in adipose tissue and spleen. Additionally, OB mice presented a higher damage to proteins and lipoperoxidation and lower activity of antioxidant enzymes in kidney and heart. Correlations were found between autonomic dysfunction with angiotensin II and inflammatory mediators, as well as between inflammation and oxidative stress. Conclusions: Our results showed that female adult ob/ob mice presented discrete diastolic dysfunction accompanied by autonomic disorder, which is associated with inflammation and oxidative stress in these animals. PMID:28878683

  8. Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice

    Directory of Open Access Journals (Sweden)

    Michelle Sartori

    2017-08-01

    Full Text Available Objective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice.Methods: Metabolic parameters, cardiac function, arterial pressure (AP, autonomic, hormonal, inflammatory, and oxidative stress markers were evaluated in 12-weeks female wild-type (WT group and ob/ob mice (OB group.Results: OB animals showed increased body weight, blood glucose, and triglyceride levels, along with glucose intolerance, when compared to WT animals. Ejection fraction (EF and AP were similar between groups; however, the OB group presented diastolic dysfunction, as well as an impairment on myocardial performance index. Moreover, the OB group exhibited important autonomic dysfunction and baroreflex sensitivity impairment, when compared to WT group. OB group showed increased Angiotensin II levels in heart and renal tissues; decreased adiponectin and increased inflammatory markers in adipose tissue and spleen. Additionally, OB mice presented a higher damage to proteins and lipoperoxidation and lower activity of antioxidant enzymes in kidney and heart. Correlations were found between autonomic dysfunction with angiotensin II and inflammatory mediators, as well as between inflammation and oxidative stress.Conclusions: Our results showed that female adult ob/ob mice presented discrete diastolic dysfunction accompanied by autonomic disorder, which is associated with inflammation and oxidative stress in these animals.

  9. 2MASS Identifications for Galactic OB Stars

    OpenAIRE

    Reed, B. Cameron

    2007-01-01

    Cross-identifications for 14,574 intrinsically luminous galactic stars (mostly OB stars) to objects in the 2MASS survey have been determined using a search box of +/-0.0015 degrees (+/- 5.4 arcsec) in both RA and Dec. Instructions on obtaining the relevant files can be obtained at othello.alma.edu/~reed/OB-2MASS.doc.

  10. Structural anatomy of telomere OB proteins.

    Science.gov (United States)

    Horvath, Martin P

    2011-10-01

    Telomere DNA-binding proteins protect the ends of chromosomes in eukaryotes. A subset of these proteins are constructed with one or more OB folds and bind with G+T-rich single-stranded DNA found at the extreme termini. The resulting DNA-OB protein complex interacts with other telomere components to coordinate critical telomere functions of DNA protection and DNA synthesis. While the first crystal and NMR structures readily explained protection of telomere ends, the picture of how single-stranded DNA becomes available to serve as primer and template for synthesis of new telomere DNA is only recently coming into focus. New structures of telomere OB fold proteins alongside insights from genetic and biochemical experiments have made significant contributions towards understanding how protein-binding OB proteins collaborate with DNA-binding OB proteins to recruit telomerase and DNA polymerase for telomere homeostasis. This review surveys telomere OB protein structures alongside highly comparable structures derived from replication protein A (RPA) components, with the goal of providing a molecular context for understanding telomere OB protein evolution and mechanism of action in protection and synthesis of telomere DNA.

  11. Hydrogen sulfide improves diabetic wound healing in ob/ob mice via attenuating inflammation.

    Science.gov (United States)

    Zhao, Huichen; Lu, Shengxia; Chai, Jiachao; Zhang, Yuchao; Ma, Xiaoli; Chen, Jicui; Guan, Qingbo; Wan, Meiyan; Liu, Yuantao

    2017-09-01

    The proposed mechanisms of impaired wound healing in diabetes involve sustained inflammation, excess oxidative stress and compromised agiogenesis. Hydrogen sulfide (H 2 S) has been reported to have multiple biological activities. We aim to investigate the role of H 2 S in impaired wound healing in ob/ob mice and explore the possible mechanisms involved. Full-thickness skin dorsal wounds were created on ob/ob mice and C57BL/6 mice. Cystathionine-γ-lyase (CSE) expression and H 2 S production were determined in granulation tissues of the wounds. Effects of NaHS on wound healing were evaluated. Inflammation and angiogenesis in granulation tissues of the wounds were examined. CSE expression, and H 2 S content were significantly reduced in granulation tissues of wounds in ob/ob mice compared with control mice. NaHS treatment significantly improved wound healing in ob/ob mice, which was associated with reduced neutrophil and macrophage infiltration, decreased production of tumor necrosis factor (TNF)-α, interleukin (IL)-6. NaHS treatment decreased metalloproteinase (MMP)-9, whereas increased collagen deposition and vascular-like structures in granulation tissues of wounds in ob/ob mice. CSE down-regulation may play a role in the pathogenesis of diabetic impaired wound healing. Exogenous H 2 S could be a potential agent to improve diabetic impaired wound healing by attenuating inflammation and increasing angiogenesis. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Impaired Muscle Regeneration in Ob/ob and Db/db Mice

    Directory of Open Access Journals (Sweden)

    Mai-Huong Nguyen

    2011-01-01

    Full Text Available In obesity and type 2 diabetes, efficient skeletal muscle repair following injury may be required, not only for restoring muscle structure and function, but also for maintaining exercise capacity and insulin sensitivity. The hypothesis of this study was that muscle regeneration would be impaired in ob/ob and db/db mice, which are common mouse models of obesity and type 2 diabetes. Muscle injury was produced by cardiotoxin injection, and regeneration was assessed by morphological and immunostaining techniques. Muscle regeneration was delayed in ob/ob and db/db mice, but not in a less severe model of insulin resistance – feeding a high-fat diet to wild-type mice. Angiogenesis, cell proliferation, and myoblast accumulation were also impaired in ob/ob and db/db mice, but not the high-fat diet mice. The impairments in muscle regeneration were associated with impaired macrophage accumulation; macrophages have been shown previously to be required for efficient muscle regeneration. Impaired regeneration in ob/ob and db/db mice could be due partly to the lack of leptin signaling, since leptin is expressed both in damaged muscle and in cultured muscle cells. In summary, impaired muscle regeneration in ob/ob and db/db mice was associated with reduced macrophage accumulation, angiogenesis, and myoblast activity, and could have implications for insulin sensitivity in the skeletal muscle of obese and type 2 diabetic patients.

  13. HSL Attenuates the Follicular Oxidative Stress and Enhances the Hair Growth in ob/ob Mice

    Directory of Open Access Journals (Sweden)

    Takeo Minematsu, PhD

    2013-10-01

    Full Text Available Summary: We demonstrated enhanced hair regeneration following topical administration of N-(3-oxododecanoyl-L-homoserine lactone (HSL in ob/ob mice. The ob/ob mice showed delayed hair regeneration (more than 6 wk after depilation, which rapidly induced transition to anagen in the hair cycle in wild-type mice. Vehicle and HSL solutions were applied to the depilated dorsal skin of ob/ob mice. The depilated skin of the HSL-treated mice was fully covered with hair, whereas no macroscopic alteration was observed in vehicle-treated group by the fourth week after depilation. Oxidative stress was drastically decreased and the expression of the antioxidative enzymes PON1 and PON3 was increased in the HSL-treated skin with highly proliferative anagen follicles. These results suggest that HSL is a candidate therapeutic agent for alopecia in metabolic syndrome.

  14. Serotonin transporter (SERT and translocator protein (TSPO expression in the obese ob/ob mouse

    Directory of Open Access Journals (Sweden)

    Santini Ferruccio

    2011-02-01

    Full Text Available Abstract Background An ever growing body of evidences is emerging concerning metabolism hormones, neurotransmitters or stress-related biomarkers as effective modulators of eating behavior and body weight in mammals. The present study sought at examining the density and affinity of two proteins related to neurotransmission and cell metabolism, the serotonin transporter SERT and the cholesterol import-benzodiazepine site TSPO (translocator protein, in a rodent leptin-lacking mutant, the obese ob/ob mouse. Binding studies were thus carried out in brain or peripheral tissues, blood platelets (SERT and kidneys (TSPO, of ob/ob and WT mice supplied with a standard diet, using the selective radiochemical ligands [3H]-paroxetine and [3H]-PK11195. Results We observed comparable SERT number or affinity in brain and platelets of ob/ob and WT mice, whilst a significantly higher [3H]-PK11195 density was reported in the brain of ob/ob animals. TSPO binding parameters were similar in the kidneys of all tested mice. By [3H]-PK11195 autoradiography of coronal hypothalamic-hippocampal sections, an increased TSPO signal was detected in the dentate gyrus (hippocampus and choroids plexus of ob/ob mice, without appreciable changes in the cortex or hypothalamic-thalamic regions. Conclusions These findings show that TSPO expression is up-regulated in cerebral regions of ob/ob leptin-deficient mice, suggesting a role of the translocator protein in leptin-dependent CNS trophism and metabolism. Unchanged SERT in mutant mice is discussed herein in the context of previous literature as the forerunner to a deeper biochemical investigation.

  15. Ob/ob mouse livers show decreased oxidative phosphorylation efficiencies and anaerobic capacities after cold ischemia.

    Directory of Open Access Journals (Sweden)

    Michael J J Chu

    Full Text Available BACKGROUND: Hepatic steatosis is a major risk factor for graft failure in liver transplantation. Hepatic steatosis shows a greater negative influence on graft function following prolonged cold ischaemia. As the impact of steatosis on hepatocyte metabolism during extended cold ischaemia is not well-described, we compared markers of metabolic capacity and mitochondrial function in steatotic and lean livers following clinically relevant durations of cold preservation. METHODS: Livers from 10-week old leptin-deficient obese (ob/ob, n = 9 and lean C57 mice (n = 9 were preserved in ice-cold University of Wisconsin solution. Liver mitochondrial function was then assessed using high resolution respirometry after 1.5, 3, 5, 8, 12, 16 and 24 hours of storage. Metabolic marker enzymes for anaerobiosis and mitochondrial mass were also measured in conjunction with non-bicarbonate tissue pH buffering capacity. RESULTS: Ob/ob and lean mice livers showed severe (>60% macrovesicular and mild (<30% microvesicular steatosis on Oil Red O staining, respectively. Ob/ob livers had lower baseline enzymatic complex I activity but similar adenosine triphosphate (ATP levels compared to lean livers. During cold storage, the respiratory control ratio and complex I-fueled phosphorylation deteriorated approximately twice as fast in ob/ob livers compared to lean livers. Ob/ob livers also demonstrated decreased ATP production capacities at all time-points analyzed compared to lean livers. Ob/ob liver baseline lactate dehydrogenase activities and intrinsic non-bicarbonate buffering capacities were depressed by 60% and 40%, respectively compared to lean livers. CONCLUSIONS: Steatotic livers have impaired baseline aerobic and anaerobic capacities compared to lean livers, and mitochondrial function indices decrease particularly from after 5 hours of cold preservation. These data provide a mechanistic basis for the clinical recommendation of shorter cold storage durations in

  16. Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice

    Science.gov (United States)

    The orexigenic hormone ghrelin is important in diabetes because it has an inhibitory effect on insulin secretion. Ghrelin ablation in leptin-deficient ob/ob (Ghrelin(-/-):ob/ob) mice increases insulin secretion and improves hyperglycemia. The physiologically relevant ghrelin receptor is the growth ...

  17. Leptin differentially regulates STAT3 activation in the ob/ob mice adipose mesenchymal stem cells

    Science.gov (United States)

    Leptin-deficient genetically obese ob/ob mice exhibit adipocyte hypertrophy and hyperplasia as well as elevated adipose tissue and systemic inflammation. Studies have shown that multipotent stem cells isolated from adult adipose tissue can differentiate into adipocytes ex vivo and thereby contribute...

  18. Leptin differentially regulate STAT3 activation in ob/ob mouse adipose mesenchymal stem cells

    Directory of Open Access Journals (Sweden)

    Zhou Zhou

    2012-12-01

    Full Text Available Abstract Background Leptin-deficient ob/ob mice exhibit adipocyte hypertrophy and hyperplasia as well as elevated adipose tissue and systemic inflammation. Multipotent stem cells isolated from adult adipose tissue can differentiate into adipocytes ex vivo and thereby contribute toward increased adipocyte cell numbers, obesity, and inflamm ation. Currently, information is lacking regarding regulation of adipose stem cell numbers as well as leptin-induced inflammation and its signaling pathway in ob/ob mice. Methods Using leptin deficient ob/ob mice, we investigated whether leptin injection into ob/ob mice increases adipose stem cell numbers and adipose tissue inflammatory marker MCP-1 mRNA and secretion levels. We also determined leptin mediated signaling pathways in the adipose stem cells. Results We report here that adipose stem cell number is significantly increased following leptin injection in ob/ob mice and with treatment of isolated stem cells with leptin in vitro. Leptin also up-regulated MCP-1 secretion in a dose- and time-dependent manner. We further showed that increased MCP-1 mRNA levels were due to increased phosphorylation of Signal Transducer and Activator of Transcription 3 (STAT3 Ser727 but not STAT3 Tyr705 phosphorylation, suggesting differential regulation of MCP-1 gene expression under basal and leptin-stimulated conditions in adipose stem cells. Conclusions Taken together, these studies demonstrate that leptin increases adipose stem cell number and differentially activates STAT3 protein resulting in up-regulation of MCP-1 gene expression. Further studies of mechanisms mediating adipose stem cell hyperplasia and leptin signaling in obesity are warranted and may help identify novel anti-obesity target strategies.

  19. iNOS inhibits hair regeneration in obese diabetic (ob/ob) mice.

    Science.gov (United States)

    Sasaki, Mari; Shinozaki, Shohei; Morinaga, Hironobu; Kaneki, Masao; Nishimura, Emi; Shimokado, Kentaro

    2018-07-02

    Previous studies have shown that androgenic alopecia is associated with metabolic syndrome and diabetes. However, the detailed mechanism whereby diabetes causes alopecia still remains unclear. We focused on the inflammatory response that is caused by diabetes or obesity, given that inflammation is a risk factor for hair loss. Inducible nitric oxide synthase (iNOS) is known to be upregulated under conditions of acute or chronic inflammation. To clarify the potential role of iNOS in diabetes-related alopecia, we generated obese diabetic iNOS-deficient (ob/ob; iNOS-KO mice). We observed that ob/ob; iNOS-KO mice were potentiated for the transition from telogen (rest phase) to anagen (growth phase) in the hair cycle compared with iNOS-proficient ob/ob mice. To determine the effect of nitric oxide (NO) on the hair cycle, we administered an iNOS inhibitor intraperitoneally (compound 1400 W, 10 mg/kg) or topically (10% aminoguanidine) in ob/ob mice. We observed that iNOS inhibitors promoted anagen transition in ob/ob mice. Next, we administered an NO donor (S-nitrosoglutathione, GSNO), to test whether NO has the telogen elongation effects. The NO donor was sufficient to induce telogen elongation in wild-type mice. Together, our data indicate that iNOS-derived NO plays a role in telogen elongation under the inflammatory conditions associated with diabetes in mice. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  20. Sequential formation of subgroups in OB associations

    International Nuclear Information System (INIS)

    Elmegreen, B.G.; Lada, C.J.

    1977-01-01

    We reconsider the structure and formation of OB association in view of recent radio and infrared observations of the adjacent molecular clouds. As a result of this reexamination, we propose that OB subgroups are formed in a step-by-step process which involves the propagation of ionization (I) and shock (S) fronts through a molecular cloud complex. OB stars formed at the edge of a molecular cloud drive these I-S fronts into the cloud. A layer of dense neutral material accumulates between the I and S fronts and eventually becomes gravitationally unstable. This process is analyzed in detail. Several arguments concerning the temperature and mass of this layer suggest that a new OB subgroup will form. After approximately one-half million years, these stars will emerge from and disrupt the star-forming layer. A new shock will be driven into the remaining molecular cloud and will initiate another cycle of star formation.Several observed properties of OB associations are shown to follow from a sequential star-forming mechanism. These include the spatial separation and systematic differences in age of OB subgroups in a given association, the regularity of subgroup masses, the alignment of subgroups along the galactic plane, and their physical expansion. Detailed observations of ionization fronts, masers, IR sources, and molecular clouds are also in agreement with this model. Finally, this mechanism provides a means of dissipating a molecular cloud and exposing less massive stars (e.g., T Tauri stars) which may have formed ahead of the shock as part of the original cloud collapsed and fragmented

  1. Manta A New BroadBand OBS

    Science.gov (United States)

    Hello, Y.; Yegikyan, M.; Charvis, P.; Philippe, O.

    2017-12-01

    Manta is a new BroadBand OBS developed at Geoazur and commercialized by Osean. The design is inspired by 3-years autonomy MUG-OBS a Multiparameter Ocean Bottom System which carry a lot of sort of sensor types. As Mug-OBS, Manta-OBS rated 6000m is designed to resist a trawling. All the components are non corrosive such polyethylene, titanium and buoyancy is ensured by syntactic foam. Equipped in standard version with a Trillium compact OBS Manta has an autonomy of 18 months, but can accept on its 4 input channels any kind of signal as low as from an hydrophone or larger from other type of a seismometer or accelerometer. Tri-axial geophones unit (2 Hz or 4.5 Hz ) can replace the seismometer and will expend the lifespan for the instrument. The seismometer is encapsulated in a central well established by four panels of the main structure to protect it from sea current convection and is decoupled from main chassis. An health bulletin is recoverable by acoustic any time to facilitate the installation and during a visit when instrument is deployed. Main parameters for acquisition can be changed by acoustics command from surface at any time. Once at the bottom, release for the main sensor installation is programmed on a timer but controlled by the tilt of the OBS. If the tilt is too important based on programmed limits, sensor will not released automatically, but this can be forced by acoustic command after returning the tilt informations to the boat operator. Manta is equipped with flash light and AIS system for easy location at recovery, and can also send it's position by Iridium satellite in case of an unexpected ascent such caused by a possible trawling if deployed in shallow water. Clock drift calculation is automatically made against GPS time signal once the OBS return at the surface. The recovery of the OBS is initiated by an acoustic command. These new features made Manta a very versatile instrument for monitoring earthquakes.

  2. uvby and JHKL photometry of OB stars in the association Cygnus OB2

    International Nuclear Information System (INIS)

    Torres-Dodgen, A.V.; Carroll, M.; Tapia, M.

    1991-01-01

    We have obtained uvby and JHK photometry of about 80 stars in the association Cygnus OB2 (VI Cygni), including some foreground stars and three infrared sources. We present colour-colour and colour-magnitude diagrams from which we derive the interstellar extinction and approximate spectral types. We confirm that the interstellar extinction law in the direction of Cyg OB2 is similar to the galactic mean. (author)

  3. Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice.

    Science.gov (United States)

    Choi, Ha-Neul; Jang, Yang-Hee; Kim, Min-Joo; Seo, Min Jeong; Kang, Byoung Won; Jeong, Yong Kee; Kim, Jung-In

    2014-04-01

    Non-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective effect of Cordyceps militaris (C. militaris) against NAFLD in an obese mouse model. Four-week-old male ob/ob mice were fed an AIN-93G diet or a diet containing 1% C. militaris water extract for 10 weeks after 1 week of adaptation. Serum glucose, insulin, free fatty acid (FFA), alanine transaminase (ALT), and proinflammatory cytokines were measured. Hepatic levels of lipids, glutathione (GSH), and lipid peroxide were determined. Consumption of C. militaris significantly decreased serum glucose, as well as homeostasis model assessment for insulin resistance (HOMA-IR), in ob/ob mice. In addition to lowering serum FFA levels, C. militaris also significantly decreased hepatic total lipids and triglyceride contents. Serum ALT activities and tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were reduced by C. militaris. Consumption of C. militaris increased hepatic GSH and reduced lipid peroxide levels. These results indicate that C. militaris can exert protective effects against development of NAFLD, partly by reducing inflammatory cytokines and improving hepatic antioxidant status in ob/ob mice.

  4. Switching performance of OBS network model under prefetched real traffic

    Science.gov (United States)

    Huang, Zhenhua; Xu, Du; Lei, Wen

    2005-11-01

    Optical Burst Switching (OBS) [1] is now widely considered as an efficient switching technique in building the next generation optical Internet .So it's very important to precisely evaluate the performance of the OBS network model. The performance of the OBS network model is variable in different condition, but the most important thing is that how it works under real traffic load. In the traditional simulation models, uniform traffics are usually generated by simulation software to imitate the data source of the edge node in the OBS network model, and through which the performance of the OBS network is evaluated. Unfortunately, without being simulated by real traffic, the traditional simulation models have several problems and their results are doubtable. To deal with this problem, we present a new simulation model for analysis and performance evaluation of the OBS network, which uses prefetched IP traffic to be data source of the OBS network model. The prefetched IP traffic can be considered as real IP source of the OBS edge node and the OBS network model has the same clock rate with a real OBS system. So it's easy to conclude that this model is closer to the real OBS system than the traditional ones. The simulation results also indicate that this model is more accurate to evaluate the performance of the OBS network system and the results of this model are closer to the actual situation.

  5. Deflection routing scheme for GMPLS-based OBS networks

    DEFF Research Database (Denmark)

    Eid, Arafat; Mahmood, Waqar; Alomar, Anwar

    2010-01-01

    Integrating the Generalized Multi-Protocol Label Switching (GMPLS) framework into an Optical Burst Switching (OBS) Control Plane is a promising solution to alleviating most of OBS performance and design issues. However, implementing the already proposed OBS deflection routing schemes is not appli...

  6. Alpha-1 adrenoceptors in brown adipose tissue of lean and ob/ob mice

    International Nuclear Information System (INIS)

    Behrens-Zaror, G.; Himms-Hagen, J.

    1986-01-01

    Obese (ob/ob) mice have a low capacity to increase thyroxine 5'-deiodinase (T4 5'-D) in brown adipose tissue (BAT) when exposed to cold. This effect is mediated by alpha-1 (A-1) adrenoceptors. The authors objective was to find out whether BAT of the ob/ob mouse has normal A-1 receptors. Saturation analysis of binding of [3H]-WB4101 at 0.05 nM to 10 μM to crude membrane preparations (100,000 g pellets from Polytron homogenates) using the LIGAND program of Munson and Rodbard, showed two populations of binding sites in BAT of lean (+/+, 11-15 wk old) mice. Acute exposure (12 h, 14 0 C) or acclimation to cold (3 wk, 14 0 C) did not alter affinity or concentration of sites. Displacement with yohimbine and prazosin indicated binding of WB4101 to A-1 receptors. Very young (5 wk) lean (+/.) and obese mice had similar affinity constants (lean 0.13 +/- 0.043 and 34.2 +/- 14.9; obese, 0.12 +/- 0.028 and 20.9 +/- 5.48 nM) and concentrations (lean 22.4 +/- 3.8 and 647 +/- 137; obese, 28.6 +/- 4.6 and 547 +/- 105 fmol/mg protein) of sites. Old (1 yr) mice had high affinity sites similar to those in younger animals (KD lean 0.19 +/- 0.028, obese, 0.25 +/- 0.075; Bmax lean, 60.2 +/- 12.1; obese, 63.1 +/- 13.5 fmol/mg protein). The authors conclude that the ob/ob mouse has normal high affinity A-1 receptors in BAT. Anomalous properties of low affinity binding in old ob/ob mice could not be characterized because of high nonspecific binding. BAT of the ob/ob mouse does not lack A-1 receptors but may have a post-receptor alteration in the A-1 adrenoceptor-mediated response

  7. Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice

    OpenAIRE

    Choi, Ha-Neul; Jang, Yang-Hee; Kim, Min-Joo; Seo, Min Jeong; Kang, Byoung Won; Jeong, Yong Kee; Kim, Jung-In

    2014-01-01

    BACKGROUND/OBJECTIVES Non-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective effect of Cordyceps militaris (C. militaris) against NAFLD in an obese mouse model. MATERIALS/METHODS Four-week-old male ob/ob mice were fed an AIN-93G diet or a diet containing 1% C. militaris water extract for 10 weeks after 1 week of adaptation. Serum glucose, insulin, free...

  8. Automated identification of OB associations in M31

    Science.gov (United States)

    Magnier, Eugene A.; Battinelli, Paolo; Lewin, Walter H. G.; Haiman, Zoltan; Paradijs, Jan Van; Hasinger, Guenther; Pietsch, Wolfgang; Supper, Rodrigo; Truemper, Joachim

    1993-01-01

    A new identification of OB associations in M31 has been performed using the Path Linkage Criterion (PLC) technique of Battinelli (1991). We found 174 associations with a very small contamination (less than 5%) by random clumps of stars. The expected total number and average size of OB associations in the region of M 31 covered by our data set (Magnier et al. 1992) are approximately 280 and approximately 90 pc, respectively. M31 associations therefore have sizes similar to those of OB associations observed in nearby galaxies, so that we can consider them to be classical OB associations. This list of OB associations will be used for the study of the spatial distribution of OB associations and their correlation with other objects. Taking into account the fact that we do not cover the entire disk of M31, we extrapolate a total number of association in M31 of approximately 420.

  9. COMP-angiopoietin-1 recovers molecular biomarkers of neuropathy and improves vascularisation in sciatic nerve of ob/ob mice.

    Directory of Open Access Journals (Sweden)

    Joanna Kosacka

    Full Text Available BACKGROUND: Leptin-deficient ob/ob mice are a model of type 2 diabetes induced peripheral neuropathy. Ob/ob mice exhibit obesity, insulin resistance, hyperglycaemia, and alterations of peripheral nerve fibres and endoneural microvessels. Here we test the hypothesis that cartilage oligomeric matrix protein (COMP-Ang-1, a soluble and stabile form of Ang-1 which promotes angiogenesis and nerve growth, improves regeneration of nerve fibres and endoneural microvessels in ob/ob mice. METHODS AND FINDINGS: COMP-Ang-1 (100 ng/ml or NaCl were intraperitoneally (i.p. injected into male (N = 184, 3-month old, ob/ob or ob/+ mice for 7 and 21 days. We measured expression of Nf68, GAP43, Cx32, Cx26, Cx43, and TNFα in sciatic nerves using Western blot analysis. To investigate the inflammation in sciatic nerves, numbers of macrophages and T-cells were counted after immunofluorescence staining. In ultrathin section, number of myelinated/non-mylinated nerve fibers, g-ratio, the thickness of Schwann cell basal lamina and microvessel endothelium were investigated. Endoneural microvessels were reconstructed with intracardial FITC injection. Treatment with COMP-Ang-1 over 21 days significantly reduced fasting blood glucose and plasma cholesterol concentrations compared to saline treated ob/ob mice. In addition, COMP-Ang-1 treatment: 1 up-regulated expression of Nf68 and GAP43; 2 improved expression of gap junction proteins including connexin 32 and 26; 3 suppressed the expression of TNFα and Cx43 and 4 led to decreased macrophage and T-cell infiltration in sciatic nerve of ob/ob mice. The significant changes of sciatic nerve ultrastructure were not observed after 21-day long COMP-Ang-1 treatment. COMP-Ang-1 treated ob/ob mice displayed regeneration of small-diameter endoneural microvessels. Effects of COMP-Ang-1 corresponded to increased phosphorylation of Akt and p38 MAPK upon Tie-2 receptor. CONCLUSIONS: COMP-Ang-1 recovers molecular biomarkers of neuropathy

  10. Enhanced glucose cycling and suppressed de novo synthesis of glucose-6-phosphate result in a net unchanged hepatic glucose output in ob/ob mice

    NARCIS (Netherlands)

    Bandsma, RHJ; Grefhorst, A; van Dijk, TH; van der Sluijs, FH; Hammer, A; Reijngoud, DJ; Kuipers, F

    2004-01-01

    Aims/hypothesis. Leptin-deficient ob/ob mice are hyperinsulinaemic and hyperglycaemic; however, the cause of hyperglycaemia remains largely unknown. Methods. Glucose metabolism in vivo in 9-h fasted ob/ob mice and lean littermates was studied by infusing [U-C-13]-glucose, [2-C-13]-glycerol,

  11. Leptin Increases Striatal Dopamine D2 Receptor Binding in Leptin-Deficient Obese (ob/ob) Mice

    Energy Technology Data Exchange (ETDEWEB)

    Pfaffly, J.; Michaelides, M.; Wang, G-J.; Pessin, J.E.; Volkow, N.D.; Thanos, P.K.

    2010-06-01

    Peripheral and central leptin administration have been shown to mediate central dopamine (DA) signaling. Leptin-receptor deficient rodents show decreased DA D2 receptor (D2R) binding in striatum and unique DA profiles compared to controls. Leptin-deficient mice show increased DA activity in reward-related brain regions. The objective of this study was to examine whether basal D2R-binding differences contribute to the phenotypic behaviors of leptin-deficient ob/ob mice, and whether D2R binding is altered in response to peripheral leptin treatment in these mice. Leptin decreased body weight, food intake, and plasma insulin concentration in ob/ob mice but not in wild-type mice. Basal striatal D2R binding (measured with autoradiography [{sup 3}H] spiperone) did not differ between ob/ob and wild-type mice but the response to leptin did. In wild-type mice, leptin decreased striatal D2R binding, whereas, in ob/ob mice, leptin increased D2R binding. Our findings provide further evidence that leptin modulates D2R expression in striatum and that these effects are genotype/phenotype dependent.

  12. Reverse time migration of multiples for OBS data

    KAUST Repository

    Zhang, Dongliang

    2014-01-01

    Reverse time migration of multiples (RTMM) is applied to OBS data with sparse receiver spacing. RTMM for OBS data unlike a marine streamer acquisition is implemented in the common receiver gathers (CRG) and provides a wider and denser illumination for each CRG than the conventional RTM of primaries. Hence, while the the conventional RTM image contains strong aliasing artifacts due to a sparser receiver interval, the RTMM image suffers from this artifacts less. This benefit of RTMM is demonstrated with numerical test on the Marmousi model for sparsely sampled OBS data.

  13. Searching for self-enrichment in Cygnus OB2

    Science.gov (United States)

    Berlanas, Sara R.; Herrero, Artemio; Comerón, Fernando; Pasquali, Anna; Simón-Díaz, Sergio

    2017-11-01

    Cygnus OB2 is a rich and relatively close (d~1.4 kpc) OB association in our Galaxy. It represents an ideal testbed for our theories about self-enrichment processes produced by pollution of the interstellar medium by successive generations of massive stars. Comerón & Pasquali (2012, A&A, 543, A101) found a correlation between the age of young stellar groups in Cygnus OB2 and their Galactic longitude. If is associated with a chemical composition gradient, it could support these self-enrichment processes.

  14. Reverse time migration of multiples for OBS data

    KAUST Repository

    Zhang, Dongliang

    2014-08-05

    Reverse time migration of multiples (RTMM) is applied to OBS data with sparse receiver spacing. RTMM for OBS data unlike a marine streamer acquisition is implemented in the common receiver gathers (CRG) and provides a wider and denser illumination for each CRG than the conventional RTM of primaries. Hence, while the the conventional RTM image contains strong aliasing artifacts due to a sparser receiver interval, the RTMM image suffers from this artifacts less. This benefit of RTMM is demonstrated with numerical test on the Marmousi model for sparsely sampled OBS data.

  15. New Results on the Nearest OB Association: Sco-Cen (Sco OB2)

    Science.gov (United States)

    Mamajek, Eric E.

    2013-01-01

    The Scorpius-Centaurus OB association (Sco OB2) is the nearest site of recent massive star formation to the Sun. The primary stellar groups in the Sco-Cen complex (including OB subgroups Upper Sco, Upper Cen Lup, and Lower Cen Cru, the neighboring molecular cloud complexes Lup, Cha, CrA, Oph, and dispersed young groups Eta Cha, Epsilon Cha, TW Hya, and Beta Pic) have been participants in a complex episode of stellar birth (and some stellar death) over the past ~20 Myr. Here I summarize some recent results on the Sco-Cen complex from the U. Rochester group: (1) isochronal analysis of the HR diagram positions for >1 Msun stars in the Upper Scorpius subgroup shows it to be twice as old as previously thought (11 Myr vs. 5 Myr), (2) analysis of high resolution optical echelle spectra show that the subgroups are approximately solar in composition, (3) surveys for lower mass members are showing that the complex shows more substructure than previously recognized, including at least one new subgroup ("Lower Sco"), and the velocity and age data for the nearest OB subgroup Lower Cen Cru argue for a bifurcation into a younger 10 Myr) southern part ("Crux") and an older 20 Myr) northern part ("Lower Centaurus"), (4) an eclipsing, multi-ring dust disk system was serendipitously discovered in the SuperWASP and ASAS light curve for the newly discovered K5-type Sco-Cen member 1SWASP J140747.93-394542.6. With regard to some recent results by other investigators, we find that (1) attempts by some authors to subsume the Sco-Cen subgroups into a single sample of a single age are unnecessarily mixing samples with a wide range in ages, and (2) I have been unable to replicate the expansion age determinations claimed by some investigators for the TW Hya and Beta Pic groups (both purported to have expansion ages of 8 and 12 Myr, respectively), which have been used by some investigators to independently age-date the Sco-Cen subgroups. We acknowledge support from NSF grant AST-1008908 and the

  16. A Novel Congestion Detection Scheme in TCP Over OBS Networks

    KAUST Repository

    Shihada, Basem; Ho, Pin-Han; Zhang, Qiong

    2009-01-01

    This paper introduces a novel congestion detection scheme for high-bandwidth TCP flows over optical burst switching (OBS) networks, called statistical additive increase multiplicative decrease (SAIMD). SAIMD maintains and analyzes a number

  17. Evidence for circumstellar obscuration of OB stars

    International Nuclear Information System (INIS)

    Bohannan, B.

    1975-01-01

    Reddish found a strong increase of color excess with increasing stellar luminosity: here referred to as the Reddish Effect: in ten young galactic clusters and associations. New photometric and spectroscopic observations drawn from the literature are combined with data used by Reddish to reconsider the color excess versus intrinsic magnitude diagrams of the same ten stellar groups. The reality of the Effect is questioned in all but one of the systems; this was accomplished by identifying possible foreground stars and by recognizing some of the brightest stars as supergiants, then applying correct intrinsic color indices. After careful reanalysis, the one stellar group to retain an indication of the Reddish Effect is Cygnus OB2. No correlation of reddening with luminosity was found for five additional very young stellar groups in the southern hemisphere; these groups should exhibit the Effect if it is a natural consequence of stellar evolution. Reddish ascribed the correlation to massive circumstellar remnants of material from which the stars formed. However, a peculiar dispersion in color excess could also be attributed to patchy dust within the stellar group. In several stellar systems previously identified as displaying the Reddish Effect, a correlation of observed color excess with dust and gas concentrations is noted on Palomar Sky Survey prints. If present, circumstellar dust clouds should []anifest their existence in modes other than a correlation of color excess with luminosity. The following possibilities are considered and all show negative results: correlation of color excess with spectral type; correlation of reddening slope E/subU//sub -//subB//E/subB//sub -//subV/ with spectral type; observable infrared excess. The preceding astrophysical arguments strongly imply that circumstellar dust remnants from stellar formation do not remain around stars during their main-sequence lifetimes. (auth)

  18. Impaired transport of thyroid hormones into livers of obese (ob/ob) mice

    International Nuclear Information System (INIS)

    Hillgartner, F.B.; Romsos, D.R.

    1988-01-01

    Obese (ob/ob) mice exhibit impaired hepatic thyroid hormone action that is mediated, at least in part, by a reduced nuclear 3,5,3'-triiodothyronine (T 3 ) receptor occupancy. The possibility that lowered occupancy in obese mice may be caused by decreased transport of T 3 across the hepatic plasma membrane was examined by measuring the unidirectional influx of [ 125 I]T 3 into livers of 8- to 10-wk-old obese and lean mice using a tissue-sampling portal vein-injection technique. Influx of [ 125 I]thyroxine (T 4 ), a substrate for T 4 5'-deiodinase, was also measured. Unidirectional clearance of T 3 and T 4 was 64 and 80% lower, respectively, in obese mice than in lean mice. Hepatic T 3 and T 4 uptake was nonsaturable in both lean and obese mice, suggesting that transport occurs by lipid-mediated free diffusion. Clearance of another lipid-soluble hormone, hydrocortisone, was also lower in obese mice than in lean mice. Decreased membrane permeability to the above hormones in obese mice may result from reported changes in membrane lipid composition. In conclusion, decreased hepatic thyroid hormone uptake may contribute to impaired thyroid hormone action and T 3 production in livers of obese mice

  19. Nuclear triiodothyronine receptor binding characteristics and occupancy in obese (ob/ob) mice

    International Nuclear Information System (INIS)

    Hillgartner, F.B.; Romsos, D.R.

    1987-01-01

    Obese (ob/ob) mice exhibit reduced adaptive thermogenesis associated with an impairment of thyroid hormone action. The mechanism underlying the latter defect was investigated by comparing the binding characteristics and occupancy of solubilized nuclear 3,5,3'-triiodothyronine (T 3 ) receptors from livers of lean and obese mice. T 3 concentration was measured by radioimmunoassay. Scatchard analysis showed minimal differences in B/sub max/ and K/sub d/ between phenotypes at both 4 and 8-10 wk of age, indicating that reduced hepatic thyroid hormone expression in obese mice is not caused by alterations in nuclear receptor concentration or affinity. In contrast, nuclear T 3 receptor occupancy (endogenous T 3 associated with the specific receptor divided by B/sub max/) was 14 and 23% lower in 4- and 8- to 10-wk old obese mice, respectively. Together with reported changes in hepatic thyroid hormone-sensitive enzymes, these data are consistent with a diminished nuclear T 3 signal initiating thyroid hormone action in obese mice. Decreased nuclear T 3 receptor occupancy may be secondary to a low transport of plasma T 3 to the nuclear pool. In conclusion, impaired hepatic thyroid hormone action in obese mice is mediated in part at least by a reduction in nuclear T 3 receptor occupancy

  20. Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice.

    Science.gov (United States)

    Chen, H-L; Tung, Y-T; Tsai, C-L; Lai, C-W; Lai, Z-L; Tsai, H-C; Lin, Y-L; Wang, C-H; Chen, C-M

    2014-09-01

    Fatty liver disease is commonly associated with obesity, insulin resistance and diabetes. Severe fatty liver is sometimes accompanied by steatohepatitis and may lead to the development of hepatocellular carcinoma. At present, there is no effective treatment for non-alcoholic fatty liver disease (NAFLD); thus, recent investigations have focused on developing effective therapeutics to treat this condition. This study aimed to evaluate the effects of kefir on the hepatic lipid metabolism of ob/ob mice, which are commonly used to model fatty liver disease. In this study, we used leptin receptor-deficient ob/ob mice as an animal disease model of NAFLD. Six-week-old ob/ob mice were orally administered the dairy product kefir (140 mg kg(-1) of body weight (BW) per day) for 4 weeks. The data demonstrated that kefir improved fatty liver syndrome on BW, energy expenditure and basal metabolic rate by inhibiting serum glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) activities (Pkefir administration also significantly reduced the macrovesicular fat quantity in liver tissue. In addition, kefir markedly decreased the expression of the genes sterol regulatory element-binding protein 1 (SREBP1), fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC) (Pkefir improves NAFLD on BW, energy expenditure and basal metabolic rate by inhibiting the lipogenesis pathway and that kefir may have the potential for clinical application to the prevention or treatment of NAFLD.

  1. Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lepob/ob mice

    International Nuclear Information System (INIS)

    Sekiya, Motohiro; Yahagi, Naoya; Tamura, Yoshiaki; Okazaki, Hiroaki; Igarashi, Masaki; Ohta, Keisuke; Takanashi, Mikio; Kumagai, Masayoshi; Takase, Satoru; Nishi, Makiko; Takeuchi, Yoshinori; Izumida, Yoshihiko; Kubota, Midori; Ohashi, Ken; Iizuka, Yoko; Yagyu, Hiroaki; Gotoda, Takanari; Nagai, Ryozo; Shimano, Hitoshi; Yamada, Nobuhiro

    2009-01-01

    It has long been a matter of debate whether the hormone-sensitive lipase (HSL)-mediated lipolysis in pancreatic β-cells can affect insulin secretion through the alteration of lipotoxicity. We generated mice lacking both leptin and HSL (Lep ob/ob /HSL -/- ) and explored the role of HSL in pancreatic β-cells in the setting of obesity. Lep ob/ob /HSL -/- developed elevated blood glucose levels and reduced plasma insulin levels compared with Lep ob/ob /HSL +/+ in a fed state, while the deficiency of HSL did not affect glucose homeostasis in Lep +/+ background. The deficiency of HSL exacerbated the accumulation of triglycerides in Lep ob/ob islets, leading to reduced glucose-stimulated insulin secretion. The deficiency of HSL also diminished the islet mass in Lep ob/ob mice due to decreased cell proliferation. In conclusion, HSL affects insulin secretary capacity especially in the setting of obesity.

  2. Hypothalamic Leptin Gene Therapy Reduces Bone Marrow Adiposity in ob/ob Mice Fed Regular and High Fat Diets

    Directory of Open Access Journals (Sweden)

    Laurence B Lindenmaier

    2016-08-01

    Full Text Available Low bone mass is often associated with increased bone marrow adiposity. Since osteoblasts and adipocytes are derived from the same mesenchymal stem cell progenitor, adipocyte formation may increase at the expense of osteoblast formation. Leptin is an adipocyte-derived hormone known to regulate energy and bone metabolism. Genetic (e.g., leptin deficiency and high fat diet-induced (e.g., leptin resistance obesity are associated with increased marrow adipose tissue (MAT and reduced bone formation. Short-duration studies suggest that leptin treatment reduces MAT and increases bone formation in leptin-deficient ob/ob mice fed a regular diet. Here, we determined the long-duration impact of increased hypothalamic leptin on marrow adipocytes and osteoblasts in ob/ob mice using recombinant adeno-associated virus (rAAV gene therapy. In a first study, eight- to ten-week-old male ob/ob mice were randomized into 4 groups: (1 untreated, (2 rAAV-Lep, (3 rAAV-green fluorescent protein (rAAV-GFP, or (4 pair-fed to rAAV-Lep. For vector administration, mice were placed in a Kopf stereotaxic apparatus, and injected intracerebroventricularly with either rAAV-Lep or rAAV-GFP (9 × 107 particles in 1.5 µl. The mice were maintained for 30 weeks following vector administration. In a second study, the impact of increased hypothalamic leptin levels on MAT was determined in mice fed high fat diets. Eight- to ten-week-old male ob/ob mice were randomized into 2 groups and treated with either rAAV-Lep or rAAV-GFP. At 7 weeks post-vector administration, half the mice in each group were switched to a high fat diet for 8 weeks. Wild type (WT controls included age-matched mice fed regular or high fat diet. Hypothalamic leptin gene therapy increased osteoblast perimeter and osteoclast perimeter with minor change in cancellous bone architecture. The gene therapy decreased MAT levels in ob/ob mice fed regular or high fat diet to values similar to WT mice fed regular diet. These

  3. Obs4MIPS: Satellite Observations for Model Evaluation

    Science.gov (United States)

    Ferraro, R.; Waliser, D. E.; Gleckler, P. J.

    2017-12-01

    This poster will review the current status of the obs4MIPs project, whose purpose is to provide a limited collection of well-established and documented datasets for comparison with Earth system models (https://www.earthsystemcog.org/projects/obs4mips/). These datasets have been reformatted to correspond with the CMIP5 model output requirements, and include technical documentation specifically targeted for their use in model output evaluation. The project holdings now exceed 120 datasets with observations that directly correspond to CMIP5 model output variables, with new additions in response to the CMIP6 experiments. With the growth in climate model output data volume, it is increasing more difficult to bring the model output and the observations together to do evaluations. The positioning of the obs4MIPs datasets within the Earth System Grid Federation (ESGF) allows for the use of currently available and planned online tools within the ESGF to perform analysis using model output and observational datasets without necessarily downloading everything to a local workstation. This past year, obs4MIPs has updated its submission guidelines to closely align with changes in the CMIP6 experiments, and is implementing additional indicators and ancillary data to allow users to more easily determine the efficacy of an obs4MIPs dataset for specific evaluation purposes. This poster will present the new guidelines and indicators, and update the list of current obs4MIPs holdings and their connection to the ESGF evaluation and analysis tools currently available, and being developed for the CMIP6 experiments.

  4. Mining the Obscured OB Star Population in Carina

    Science.gov (United States)

    Smith, Michael

    2016-04-01

    Massive OB stars are very influential objects in the ecology of galaxies like our own. Current catalogues of Galactic OB stars are heavily biased towards bright (g selected OB stars across the entire Southern Galactic plane, both within clusters and in the field, down to ∼20th magnitude in g. For the first time, a complete accounting of the OB star runaway phenomenon becomes possible. Along with making the primary selection using VPHAS+ colours, I have performed Markov-Chain Monte Carlo fitting of the spectral energy distributions of the selected stars by combining VPHAS+ u, g, r, i with published J, H, K photometry. This gives rough constraints on effective temperature and distance, whilst delivering much more precise reddening parameters A0 and RV - allowing us to build a much richer picture of how extinction and extinction laws vary across the Galactic Plane. My thesis begins with a description of the method of photometric selection of OB star candidates and its validation across a 2 square degree field including the well-known young massive star cluster Westerlund 2 (Mohr-Smith et al., 2015). Following on from this I present spectroscopy with AAOmega of 283 candidates identified by our method, which confirms that ∼94% of the sample are the expected O and early B stars. I then develop this method further and apply it to a Galactic Plane strip of 42 square-degrees that runs from the Carina Arm tangent region to the much studied massive cluster in NGC 3603. A new aspect I attend to in this expansion of method is tightening up the uniform photometric calibration of the data, paying particular attention to the always-challenging u band. This leads to a new and reliable catalogue of 5915 OB stars. As well as increasing the numbers of identified massive stars in this large region of the sky by nearly an order of magnitude, a more complete picture of massive star formation in the Carina Arm has emerged. I have found a broad over-density of O stars around the highly

  5. Recent Seismic Experiments of OBS in the South China Sea

    Science.gov (United States)

    Ruan, A.; Li, J.; Wu, Z.

    2012-12-01

    Since 2006 some research institutions of China have carried out some important seismic experiments by using ocean bottom seismometer(OBS) in the South China Sea (SCS) and obtained many concrete progresses in modeling the crustal structure of SCS and also in understanding of its formation and evolution as well. In 2006 three wide-angle profiles were completed in the northern margin, named OBS2006-1 across the northwestern sub-basin, OBS2006-2 parallel to the sea basin boundary and OBS2006-3 across the Dongsha Rise and Chaoshan Depression respectively. In 2010 two wide- angle profiles were completed, named OBS2010-1 and OBS 2010-2 both perpendicular to the northern off-shore faulting system. During 2009-2011 four wide-angle profiles were completed in the southern margin, named OBS973-1 from southern margin to the southwestern sub-basin, OBS973-2 from Liyue Bank to the southwestern sub-basin and OBS973-3 from Xisha to the southwestern sub-basin, OBS2011-2 from Xisha to Hainan Island respectively. In 2011 two 3D seismic array of OBS were completed in the Zhongnan-Changlong sea mount chain and Huangyan-Zhenbei sea mount chain respectively. Here we present some primary but important results as follows. (1) The velocity model of OBS2006-1 indicates that the crust under the continental slope decreases from 21km to 11km, and to 7.7km in the northwestern sub-basin with Moho depth ascends from 21km to 11km. The tectonic geometry and velocity structure of the northwestern sub-basin and its margins on both sides shows symmetrical and conjugate and indicates pure shear mode of continental margin rifting mechanism. (2) The velocity model of OBS2006-3 reveals remarkable thickness with maximum 8 km of the Mesozoic sediment in Chaoshan Depression in which velocity increases downward from 4.4 km/s at top to 5.3 km/s at the bottom. The buried depth of Moho decreases from 24-25 km under Dongsha Rise to 17 km in the lower slope and an obviously velocity abnormal is detected in the upper

  6. Expression of Leptin (Ob Gene Product) in Reproductive System ...

    African Journals Online (AJOL)

    Purpose: To determine serum leptin and its ob mRNA expression both in the PCOS and non-PCOS ovary, endometrium and adipose tissue in normal or polycystic ovary syndrome (PCOS) in South Indian population. PCOS (Polycystic Ovary Syndrome) and non-PCOS subject's endometrium, ovary and adipose tissue were ...

  7. iPLA2β deficiency attenuates obesity and hepatic steatosis in ob/ob mice through hepatic fatty-acyl phospholipid remodeling.

    Science.gov (United States)

    Deng, Xiuling; Wang, Jiliang; Jiao, Li; Utaipan, Tanyarath; Tuma-Kellner, Sabine; Schmitz, Gerd; Liebisch, Gerhard; Stremmel, Wolfgang; Chamulitrat, Walee

    2016-05-01

    PLA2G6 or GVIA calcium-independent PLA2 (iPLA2β) is identified as one of the NAFLD modifier genes in humans, and thought to be a target for NAFLD therapy. iPLA2β is known to play a house-keeping role in phospholipid metabolism and remodeling. However, its role in NAFLD pathogenesis has not been supported by results obtained from high-fat feeding of iPLA2β-null (PKO) mice. Unlike livers of human NAFLD and genetically obese rodents, fatty liver induced by high-fat diet is not associated with depletion of hepatic phospholipids. We therefore tested whether iPLA2β could regulate obesity and hepatic steatosis in leptin-deficient mice by cross-breeding PKO with ob/ob mice to generate ob/ob-PKO mice. Here we observed an improvement in ob/ob-PKO mice with significant reduction in serum enzymes, lipids, glucose, insulin as well as improved glucose tolerance, and reduction in islet hyperplasia. The improvement in hepatic steatosis measured by liver triglycerides, fatty acids and cholesterol esters was associated with decreased expression of PPARγ and de novo lipogenesis genes, and the reversal of β-oxidation gene expression. Notably, ob/ob livers contained depleted levels of lysophospholipids and phospholipids, and iPLA2β deficiency in ob/ob-PKO livers lowers the former, but replenished the latter particularly phosphatidylethanolamine (PE) and phosphatidylcholine (PC) that contained arachidonic (AA) and docosahexaenoic (DHA) acids. Compared with WT livers, PKO livers also contained increased PE and PC containing AA and DHA. Thus, iPLA2β deficiency protected against obesity and ob/ob fatty liver which was associated with hepatic fatty-acyl phospholipid remodeling. Our results support the deleterious role of iPLA2β in severe obesity associated NAFLD. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Leptin Reduces the Expression and Increases the Phosphorylation of the Negative Regulators of GLUT4 Traffic TBC1D1 and TBC1D4 in Muscle of ob/ob Mice

    Science.gov (United States)

    Sáinz, Neira; Rodríguez, Amaia; Catalán, Victoria; Becerril, Sara; Ramírez, Beatriz; Lancha, Andoni; Burgos-Ramos, Emma; Gómez-Ambrosi, Javier; Frühbeck, Gema

    2012-01-01

    Leptin improves insulin sensitivity in skeletal muscle. Our goal was to determine whether proteins controlling GLUT4 traffic are altered by leptin deficiency and in vivo leptin administration in skeletal muscle of wild type and ob/ob mice. Leptin-deficient ob/ob mice were divided in three groups: control, leptin-treated (1 mg/kg/d) and leptin pair-fed ob/ob mice. Microarray analysis revealed that 1,546 and 1,127 genes were regulated by leptin deficiency and leptin treatment, respectively. Among these, we identified 24 genes involved in intracellular vesicle-mediated transport in ob/ob mice. TBC1 domain family, member 1 (Tbc1d1), a negative regulator of GLUT4 translocation, was up-regulated (P = 0.001) in ob/ob mice as compared to wild types. Importantly, leptin treatment reduced the transcript levels of Tbc1d1 (P<0.001) and Tbc1d4 (P = 0.004) in the leptin-treated ob/ob as compared to pair-fed ob/ob animals. In addition, phosphorylation levels of TBC1D1 and TBC1D4 were enhanced in leptin-treated ob/ob as compared to control ob/ob (P = 0.015 and P = 0.023, respectively) and pair-fed ob/ob (P = 0.036 and P = 0.034, respectively) mice. Despite similar GLUT4 protein expression in wild type and ob/ob groups a different immunolocalization of this protein was evidenced in muscle sections. Leptin treatment increased GLUT4 immunoreactivity in gastrocnemius and extensor digitorum longus sections of leptin-treated ob/ob mice. Moreover, GLUT4 protein detected in immunoprecipitates from TBC1D4 was reduced by leptin replacement compared to control ob/ob (P = 0.013) and pair-fed ob/ob (P = 0.037) mice. Our findings suggest that leptin enhances the intracellular GLUT4 transport in skeletal muscle of ob/ob animals by reducing the expression and activity of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4. PMID:22253718

  9. Radio observations of the CMa OB1 H II regions

    International Nuclear Information System (INIS)

    Gaylard, M.J.; Kemball, A.J.

    1984-01-01

    A sensitive 10 0 x 15 0 13-cm map made of the CMa OB1 H II regions' radio emission shows a strong similarity to Hα emission photographs. Sharpless 296 is shown to consist of a prominent central and western arc completed by a weaker southern loop, and with a faint northern bar. The emission is thermal, superimposed over a predominantly non-thermal background. The H142α recombination line has been detected at eight positions in S296, and in S292 and S297. The average electron temperature in S296 is 6900 +- 1300 K. The UV fluxes from the CMa OB1 stars account for the observed emission measures of the H II regions. The H142α 1sr velocities indicate that the ionized material is in contact with the molecular clouds. (author)

  10. Neutral hydrogen in the stellar accociation Scorpius OB-2

    Energy Technology Data Exchange (ETDEWEB)

    Bystrova, N.V.

    1979-01-01

    The distribution of neutral hydrogen connected with the stellar association Scorpius OB-2 is more complex than the expanding semienvelope suggested earlier. The neutral gas is in connection with the nebulae S1, S7, S9 and with H/sub ..cap alpha../-filaments found in the association and giving it the appearence of a spiral galaxy. The HI-distribution is in disagreement with the model of a supernova remnant.

  11. Variability of X-ray emission from OB stars

    International Nuclear Information System (INIS)

    Collura, A.; Sciortino, S.; Serio, S.; Vaiana, G. S.; Harnden, F.R. JR.; Osservatorio Astronomico, Palermo, Italy; Harvard-Smithsonian Center for Astrophysics, Cambridge, MA)

    1989-01-01

    The variability in soft X-ray emission of 12 OB stars is studied. Two different methods of analysis, one more suitable for detecting short-term variations, the other aimed at detecting long time-scale variations, are applied to all stars in the sample. The long-term variability analysis shows that Cyg-OB2 8A Zeta Pup and Delta Ori exhibit significant count rate variations between different data sections. Similar variations are marginally detected in 15 Mon; the count rate variations for the other eight stars are consistent with statistical fluctuations. The light curve of Cyg-OB2 8A suggests the existence of two different emission levels. The short-term variability analysis detects marginal variability in Tau Sco with an effective amplitude of about 30 percent and a time scale of about 50 s. The upper limits to the effective short-term variability amplitude for all other sample stars are in the 10-30 percent range. 30 refs

  12. ObsPy: A Python Toolbox for Seismology

    Science.gov (United States)

    Krischer, Lion; Megies, Tobias; Sales de Andrade, Elliott; Barsch, Robert; MacCarthy, Jonathan

    2017-04-01

    In recent years the Python ecosystem evolved into one of the most powerful and productive scientific environments across disciplines. ObsPy (https://www.obspy.org) is a fully community-driven, open-source project dedicated to providing a bridge for seismology into that ecosystem. It does so by offering Read and write support for essentially every commonly used data format in seismology with a unified interface and automatic format detection. This includes waveform data (MiniSEED, SAC, SEG-Y, Reftek, …) as well as station (SEED, StationXML, …) and event meta information (QuakeML, ZMAP, …). Integrated access to the largest data centers, web services, and real-time data streams (FDSNWS, ArcLink, SeedLink, ...). A powerful signal processing toolbox tuned to the specific needs of seismologists. Utility functionality like travel time calculations with the TauP method, geodetic functions, and data visualizations. ObsPy has been in constant development for more than seven years and is developed and used by scientists around the world with successful applications in all branches of seismology. Additionally it nowadays serves as the foundation for a large number of more specialized packages. This presentation will give a short overview of the capabilities of ObsPy and point out several representative or new use cases. Additionally we will discuss the road ahead as well as the long-term sustainability of open-source scientific software.

  13. OBS Technologies and permanent seismic Stations at Sea

    Science.gov (United States)

    Makris, J.; Nikolova, S. B.

    2003-04-01

    An off-shore telemetric system was developed during last 2 years. It consists of a buoy unit, OBS with seismic sensor and digitizer at the sea floor and coaxial cable for transferring data from the sea. The buoy unit includes all components for recording and transmitting data to the base station. A solar panel and wind generator are the sources of energy that charge the batteries in the buoy. An Omni directional antenna and a radio modem are used for data transfer. The buoy can be connected also to mobile network or satellite. The Seismic recording unit is SEDIS IV developed in GeoPro GmbH which is a 6 channel data logger equipped with a hard disk of 30 GByte capacity and a flash memory of 0.5 Gbyte which can continuously record at different sampling rate (from 31.25 to 1000sps). The operating system for SEDIS IV is LINUX, with possible data compression, event location and extraction. The data transfer and supply of the power to seismometer and ADC unit in OBS sphere is done through coaxial cable, connecting the buoy unit and OBS. The whole system was tested for a period of one month (October 2002) within frame of Nestor program in Pilos (Greece) and worked successfully.

  14. ADDITIONAL MASSIVE BINARIES IN THE CYGNUS OB2 ASSOCIATION

    International Nuclear Information System (INIS)

    Kiminki, Daniel C.; Kobulnicky, Henry A.; Ewing, Ian; Lundquist, Michael; Alexander, Michael; Vargas-Alvarez, Carlos; Choi, Heather; Bagley Kiminki, Megan M.; Henderson, C. B.

    2012-01-01

    We report the discovery and orbital solutions for two new OB binaries in the Cygnus OB2 Association, MT311 (B2V + B3V) and MT605 (B0.5V + B2.5:V). We also identify the system MT429 as a probable triple system consisting of a tight eclipsing 2.97 day B3V+B6V pair and a B0V at a projected separation of 138 AU. We further provide the first spectroscopic orbital solutions to the eclipsing, double-lined, O-star binary MT696 (O9.5V + B1:V), the double-lined, early B binary MT720 (B0-1V + B1-2V), and the double-lined, O-star binary MT771 (O7V + O9V). These systems exhibit orbital periods between 1.5 days and 12.3 days, with the majority having P <6 days. The two new binary discoveries and six spectroscopic solutions bring the total number of known massive binaries in the central region of the Cygnus OB2 Association to 20, with all but two having full orbital solutions.

  15. ADDITIONAL MASSIVE BINARIES IN THE CYGNUS OB2 ASSOCIATION

    Energy Technology Data Exchange (ETDEWEB)

    Kiminki, Daniel C.; Kobulnicky, Henry A.; Ewing, Ian; Lundquist, Michael; Alexander, Michael; Vargas-Alvarez, Carlos; Choi, Heather [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82070 (United States); Bagley Kiminki, Megan M. [Department of Astronomy, University of Arizona, Tucson, AZ 85721 (United States); Henderson, C. B. [Department of Astronomy, Ohio State University, Columbus, OH 43210 (United States)

    2012-03-01

    We report the discovery and orbital solutions for two new OB binaries in the Cygnus OB2 Association, MT311 (B2V + B3V) and MT605 (B0.5V + B2.5:V). We also identify the system MT429 as a probable triple system consisting of a tight eclipsing 2.97 day B3V+B6V pair and a B0V at a projected separation of 138 AU. We further provide the first spectroscopic orbital solutions to the eclipsing, double-lined, O-star binary MT696 (O9.5V + B1:V), the double-lined, early B binary MT720 (B0-1V + B1-2V), and the double-lined, O-star binary MT771 (O7V + O9V). These systems exhibit orbital periods between 1.5 days and 12.3 days, with the majority having P <6 days. The two new binary discoveries and six spectroscopic solutions bring the total number of known massive binaries in the central region of the Cygnus OB2 Association to 20, with all but two having full orbital solutions.

  16. Star formation in the Monoceros OB1 dark cloud

    International Nuclear Information System (INIS)

    Margulis, M.S.

    1987-01-01

    A survey of the Monoceros OB1 dark cloud was made for molecular outflows and young stellar objects. In all, nine molecular outflows and thirty far-infrared sources were identified in a portion of the cloud composed of about 3 x 10 4 M of material. Statistical arguments suggest that 90% of the far-infrared sources actually are young stellar objects embedded in the cloud. If the star formation rate in the Mon OB1 cloud is roughly constant with time, then molecular outflows in the cloud should be able to support it against collapse due to gravity. This suggests that the birthrate of outflows in the solar neighborhood is very high. In fact, regardless of considerations of cloud support, the large number of outflows identified in the Mon OB1 cloud and the propensity of the youngest stellar objects in the cloud to be associated with outflows suggest that outflows have a high birthrate in the solar neighborhood and are part of a common stage in early stellar evolution. The young stellar objects identified in the cloud can be fit into a spectral classification system. Also, the outflow phase in early stellar evolution tends to occur at about the time that young stellar objects lose a large fraction of their circumstellar envelopes

  17. Determining OBS Instrument Orientations: A Comparison of Algorithms

    Science.gov (United States)

    Doran, A. K.; Laske, G.

    2015-12-01

    The alignment of the orientation of the horizontal seismometer components with the geographical coordinate system is critical for a wide variety of seismic analyses, but the traditional deployment method of ocean bottom seismometers (OBS) precludes knowledge of this parameter. Current techniques for determining the orientation predominantly rely on body and surface wave data recorded from teleseismic events with sufficiently large magnitudes. Both wave types experience lateral refraction between the source and receiver as a result of heterogeneity and anisotropy, and therefore the arrival angle of any one phase can significantly deviate from the great circle minor arc. We systematically compare the results and uncertainties obtained through current determination methods, as well as describe a new algorithm that uses body wave, surface wave, and differential pressure gauge data (where available) to invert for horizontal orientation. To start with, our method is based on the easily transportable computer code of Stachnik et al. (2012) that is publicly available through IRIS. A major addition is that we utilize updated global dispersion maps to account for lateral refraction, as was done by Laske (1995). We also make measurements in a wide range of frequencies, and analyze surface wave trains of repeat orbits. Our method has the advantage of requiring fewer total events to achieve high precision estimates, which is beneficial for OBS deployments that can be as short as weeks. Although the program is designed for the purpose of use with OBS instruments, it also works with standard land installations. We intend to provide the community with a program that is easy to use, requires minimal user input, and is optimized to work with data cataloged at the IRIS DMC.

  18. A Search for Pulsar Companions to OB Runaway Stars

    Science.gov (United States)

    Kaspi, V. M.

    1995-01-01

    We have searched for radio pulsar companions to 40 nearby OB runaway stars. Observations were made at 474 and 770 MHz with the NRAO 140 ft telescope. The survey was sensitive to long- period pulsars with flux densities of 1 mJy or more. One previously unknown pulsar was discovered, PSRJ2044+4614, while observing towards target O star BD+45,3260. Follow-up timing observations of the pulsar measured its position to high precision, revealing a 9' separation between the pulsar and the target star, unequivocally indicating they are not associated.

  19. ObsPy - A Python Toolbox for Seismology - and Applications

    Science.gov (United States)

    Krischer, L.; Megies, T.; Barsch, R.; MacCarthy, J.; Lecocq, T.; Koymans, M. R.; Carothers, L.; Eulenfeld, T.; Reyes, C. G.; Falco, N.; Sales de Andrade, E.

    2017-12-01

    Recent years witnessed the evolution of Python's ecosystem into one of the most powerful and productive scientific environments across disciplines. ObsPy (https://www.obspy.org) is a fully community driven, open-source project dedicated to provide a bridge for seismology into that ecosystem. It is a Python toolbox offering: Read and write support for essentially every commonly used data format in seismology with a unified interface and automatic format detection. This includes waveform data (MiniSEED, SAC, SEG-Y, Reftek, …) as well as station (SEED, StationXML, SC3ML, …) and event meta information (QuakeML, ZMAP, …). Integrated access to the largest data centers, web services, and real-time data streams (FDSNWS, ArcLink, SeedLink, ...). A powerful signal processing toolbox tuned to the specific needs of seismologists. Utility functionality like travel time calculations with the TauP method, geodetic functions, and data visualizations. ObsPy has been in constant development for more than eight years and is developed and used by scientists around the world with successful applications in all branches of seismology. Additionally it nowadays serves as the foundation for a large number of more specialized packages. Newest features include: Full interoperability of SEED and StationXML/Inventory objects Access to the Nominal Response Library (NRL) for easy and quick creation of station metadata from scratch Support for the IRIS Federated Catalog Service Improved performance of the EarthWorm client Several improvements to MiniSEED read/write module Improved plotting capabilities for PPSD (spectrograms, PSD of discrete frequencies over time, ..) Support for.. Reading ArcLink Inventory XML Reading Reftek data format Writing SeisComp3 ML (SC3ML) Writing StationTXT format This presentation will give a short overview of the capabilities of ObsPy and point out several representative or new use cases and show-case some projects that are based on ObsPy, e.g.: seismo

  20. Modelling of slag emulsification and slag reduction in CAS-OB process

    OpenAIRE

    Sulasalmi, P. (Petri)

    2016-01-01

    Abstract Composition Adjustment by Sealed argon bubbling – Oxygen Blowing (CAS-OB) process is a ladle treatment process that was developed for chemical heating and alloying of steel. The main stages of the process are heating, (possible) alloying and reduction of slag. The CAS-OB process aims for homogenization and control of the composition and temperature of steel. In this dissertation, a mathematical reaction model was developed for the slag reduction stage of the CAS-OB process. Sl...

  1. The Seismic Broad Band Western Mediterranean (wm) Network and the Obs Fomar Pool: Current state and Obs activities.

    Science.gov (United States)

    Pazos, Antonio; Davila, Jose Martin; Buforn, Elisa; Bezzeghoud, Mourad; Harnafi, Mimoun; Mattesini, Mauricio; Caldeira, Bento; Hanka, Winfried; El Moudnib, Lahcen; Strollo, Angelo; Roca, Antoni; Lopez de Mesa, Mireya; Dahm, Torsten; Cabieces, Roberto

    2016-04-01

    The Western Mediterranean (WM) seismic network started in 1996 as an initiative of the Royal Spanish Navy Observatory (ROA) and the Universidad Complutense de Madrid (UCM), with the collaboration of the GeoForschungsZentrum (GFZ) of Potsdam. A first broad band seismic station (SFUC) was installed close to Cádiz (South Spain). Since then, additional stations have been installed in the Ibero-Moghrebian region. In 2005, the "WM" code was assigned by the FDSN and new partners were jointed: Evora University (UEVO, Portugal), the Scientifique Institute of Rabat (ISRABAT, Morocco), and GFZ. Now days, the WM network is composed by 15 BB stations, all of them with Streckaisen STS-2 or STS-2.5 sensors, Quanterra or Earthdata digitizers and SeiscomP. Most them have co-installed a permanent geodetic GPS stations, and some them also have an accelerometer. There are 10 stations deployed in Spanish territory (5 in the Iberian peninsula, 1 in Balearic islands and 4 in North Africa Spanish places) with VSAT or Internet communications, 2 in Portugal (one of them without real time), and 3 in Morocco (2 VSAT and 1 ADSL). Additionally, 2 more stations (one in South Spain and one in Morocco) will be installed along this year. Additionally ROA has deployed a permanent real time VBB (CMG-3T: 360s) station at the Alboran Island. Due to the fact that part of the seismic activity is located at marine areas, and also because of the poor geographic azimuthal coverage at some zones provided by the land stations (specially in the SW of the San Vicente Cape area), ROA and UCM have acquired six broad band "LOBSTERN" OBS, manufactured by KUM (Kiel, Germany), conforming the OBS FOMAR pool. Three of them with CMG-40T sensor and the other with Trillium 120. These OBS were deployed along the Gibraltar strait since January to November 2014 to study the microseismicity in the Gibraltar strait area. In September 2015 FOMAR network has been deployed in SW of the San Vicente Cape for 8 months as a part of

  2. Dietary Capsaicin Improves Glucose Homeostasis and Alters the Gut Microbiota in Obese Diabetic ob/ob Mice

    Directory of Open Access Journals (Sweden)

    Jun-Xian Song

    2017-08-01

    Full Text Available Background: The effects of capsaicin on obesity and glucose homeostasis are still controversial and the mechanisms underlying these effects remain largely unknown. This study aimed to investigate the potential relationship between the regulation of obesity and glucose homeostasis by dietary capsaicin and the alterations of gut microbiota in obese diabetic ob/ob mice.Methods: The ob/ob mice were subjected to a normal, low-capsaicin (0.01%, or high-capsaicin (0.02% diet for 6 weeks, respectively. Obesity phenotypes, glucose homeostasis, the gut microbiota structure and composition, short-chain fatty acids, gastrointestinal hormones, and pro-inflammatory cytokines were measured.Results: Both the low- and high-capsaicin diets failed to prevent the increase in body weight, adiposity index, and Lee's obesity index. However, dietary capsaicin at both the low and high doses significantly inhibited the increase of fasting blood glucose and insulin levels. These inhibitory effects were comparable between the two groups. Similarly, dietary capsaicin resulted in remarkable improvement in glucose and insulin tolerance. In addition, neither the low- nor high-capsaicin diet could alter the α-diversity and β-diversity of the gut microbiota. Taxonomy-based analysis showed that both the low- and high-capsaicin diets, acting in similar ways, significantly increased the Firmicutes/Bacteroidetes ratio at the phylum level as well as increased the Roseburia abundance and decreased the Bacteroides and Parabacteroides abundances at the genus level. Spearman's correlation analysis revealed that the Roseburia abundance was negatively while the Bacteroides and Parabacteroides abundances were positively correlated to the fasting blood glucose level and area under the curve by the oral glucose tolerance test. Finally, the low- and high-capsaicin diets significantly increased the fecal butyrate and plasma total GLP-1 levels, but decreased plasma total ghrelin, TNF-α, IL-1

  3. Genetic ablation of phosphatidylcholine transfer protein/StarD2 in ob/ob mice improves glucose tolerance without increasing energy expenditure.

    Science.gov (United States)

    Krisko, Tibor I; LeClair, Katherine B; Cohen, David E

    2017-03-01

    Phosphatidylcholine transfer protein (PC-TP; synonym StarD2) is highly expressed in liver and oxidative tissues. PC-TP promotes hepatic glucose production during fasting and aggravates glucose intolerance in high fat fed mice. However, because PC-TP also suppresses thermogenesis in brown adipose tissue (BAT), its direct contribution to obesity-associated diabetes in mice remains unclear. Here we examined the effects of genetic PC-TP ablation on glucose homeostasis in leptin-deficient ob/ob mice, which exhibit both diabetes and altered thermoregulation. Mice lacking both PC-TP and leptin (Pctp -/- ;ob/ob) were prepared by crossing Pctp -/- with ob/+ mice. Glucose homeostasis was assessed by standard assays, and energy expenditure was determined by indirect calorimetry using a comprehensive laboratory animal monitoring system, which also recorded physical activity and food intake. Body composition was determined by NMR and hepatic lipids by enzymatic assays. Core body temperature was measured using a rectal thermocouple probe. Pctp -/- ;ob/ob mice demonstrated improved glucose homeostasis, as evidenced by markedly improved glucose and pyruvate tolerance tests, without changes in insulin tolerance. However, there were no differences in EE at any ambient temperature. There were also no effects of PC-TP expression on physical activity, food intake or core body temperature. Improved glucose tolerance in Pctp -/- ;ob/ob mice in the absence of increases in energy expenditure or core body temperature indicates a direct pathogenic role for PC-TP in diabetes in leptin deficient mice. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Decreased triiodothyronine receptor binding in skeletal muscle nuclei and erythrocyte membranes of obese (ob/ob) mice

    International Nuclear Information System (INIS)

    Gilvary, E.P.

    1988-01-01

    Hindlimb skeletal muscle weights and binding of L-tri-iodothyronine (T 3 ) to isolated nuclei of this tissue were investigated in obese (ob/ob) mice and their lean littermates. Maximal binding capacities (Bmax) and dissociation constants (Kd) were determined by incubating isolated muscle nuclei with increasing conc. of 125 I-T 3 (0.4 nM to 4nM). At 12 wks. of age, although weighing substantially more, obese mice had only 55% as much muscle mass as their lean littermates. There was no phenotype effect observed for Kd, however, Bmax was significantly less for the obese mice. In a second experiment, a 16-wk. feeding study was conducted with 4 groups of mice according to the following design: lean mice fed rodent chow; obese mice fed rodent chow; obese mice, n-6 fatty acid (FA)-rich diet; and obese mice, n-3FA-rich diet. Erythrocyte T 3 receptor binding capacities were measured by incubating red cell ghosts from mice of these 4 groups with 125 I-T 3 . As with skeletal muscle nuclei there were no phenotype effects observed for Kd between any two groups. In contrasts obese mice fed chow and n-6FA-rich diets both exhibited lower Bmax than their lean counterparts, while no significant difference was observed between the latter group and the obese mice fed an n-3FA-rich diet. Bmax values of the n-6 group were also decreased compared to the n-3 group

  5. Oral delivery of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, synthetic peptide leptin mimetics: Immunofluorescent localization in the mouse hypothalamus.

    Science.gov (United States)

    Anderson, Brian M; Jacobson, Lauren; Novakovic, Zachary M; Grasso, Patricia

    2017-06-01

    This study describes the localization of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, synthetic peptide leptin mimetics, in the hypothalamus of Swiss Webster and C57BL/6J wild-type mice, leptin-deficient ob/ob mice, and leptin-resistant diet-induced obese (DIO) mice. The mice were given [D-Leu-4]-OB3 or MA-[D-Leu-4]-OB3 in 0.3% dodecyl maltoside by oral gavage. Once peak serum concentrations were reached, the mice received a lethal dose of pentobarbital and were subjected to intracardiac perfusion fixation. The brains were excised, post-fixed in paraformaldehyde, and cryo-protected in sucrose. Free-floating frozen coronal sections were cut at 25-µm and processed for imaging by immunofluorescence microscopy. In all four strains of mice, dense staining was concentrated in the area of the median eminence, at the base and/or along the inner wall of the third ventricle, and in the brain parenchyma at the level of the arcuate nucleus. These results indicate that [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3 cross the blood-brain barrier and concentrate in an area of the hypothalamus known to regulate energy balance and glucose homeostasis. Most noteworthy is the localization of [D-Leu-4]-OB3 immunoreactivity within the hypothalamus of DIO mice via a conduit that is closed to leptin in this rodent model, and in most cases of human obesity. Together with our previous studies describing the effects of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3 on energy balance, glucose regulation, and signal transduction pathway activation, these findings are consistent with a central mechanism of action for these synthetic peptide leptin mimetics, and suggest their potential usefulness in the management of leptin-resistant obesity and type 2 diabetes in humans. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Mass loss rates of OB stars derived from infrared observations

    International Nuclear Information System (INIS)

    Tanzi, E.G.; Tarenghi, M.; Panagia, N.

    1981-01-01

    In this paper the authors report briefly on a study of the mass loss of early type stars in the infrared. Up to now near infrared (1.25 - 4.8 μ) broad band photometry of 70 southern OB stars of various luminosity class has been secured. Program stars have been selected, among those bright enough in the infrared to give a suitable photometric accuracy, in order to cover a wide range of spectral types. 37 stars are found to exhibit emission in excess over a blackbody photospheric continuum, which is interpreted in terms of gas ejected in the form of an accelerated wind. By means of model calculations the corresponding mass loss rates are derived. The obtained values compare well with those determined independently by various authors for stars in common. Their data show that mass loss rates increase with luminosity and are a decreasing function of surface gravity. (Auth.)

  7. Dropping Probability Reduction in OBS Networks: A Simple Approach

    KAUST Repository

    Elrasad, Amr

    2016-08-01

    In this paper, we propose and derive a slotted-time model for analyzing the burst blocking probability in Optical Burst Switched (OBS) networks. We evaluated the immediate and delayed signaling reservation schemes. The proposed model compares the performance of both just-in-time (JIT) and just-enough-time (JET) signaling protocols associated with of void/non-void filling link scheduling schemes. It also considers none and limited range wavelength conversions scenarios. Our model is distinguished by being adaptable to different offset-time and burst length distributions. We observed that applying a limited range of wavelength conversion, burst blocking probability is reduced by several orders of magnitudes and yields a better burst delivery ratio compared with full wavelength conversion.

  8. Performance analysis of signaling protocols on OBS switches

    Science.gov (United States)

    Kirci, Pinar; Zaim, A. Halim

    2005-10-01

    In this paper, Just-In-Time (JIT), Just-Enough-Time (JET) and Horizon signalling schemes for Optical Burst Switched Networks (OBS) are presented. These signaling schemes run over a core dWDM network and a network architecture based on Optical Burst Switches (OBS) is proposed to support IP, ATM and Burst traffic. In IP and ATM traffic several packets are assembled in a single packet called burst and the burst contention is handled by burst dropping. The burst length distribution in IP traffic is arbitrary between 0 and 1, and is fixed in ATM traffic at 0,5. Burst traffic on the other hand is arbitrary between 1 and 5. The Setup and Setup ack length distributions are arbitrary. We apply the Poisson model with rate λ and Self-Similar model with pareto distribution rate α to identify inter-arrival times in these protocols. We consider a communication between a source client node and a destination client node over an ingress and one or more multiple intermediate switches.We use buffering only in the ingress node. The communication is based on single burst connections in which, the connection is set up just before sending a burst and then closed as soon as the burst is sent. Our analysis accounts for several important parameters, including the burst setup, burst setup ack, keepalive messages and the optical switching protocol. We compare the performance of the three signalling schemes on the network under as burst dropping probability under a range of network scenarios.

  9. Observations of mass loss from OB and Wolf-Rayet stars

    International Nuclear Information System (INIS)

    Barlow, M.J.

    1982-01-01

    In this review, three observationally accessible parameters of the winds of OB and Wolf-Rayet stars are discussed: (1) Terminal velocities, (2) Velocity laws, (3) Mass loss rates. In addition, some discussion of the ionisation structure of the winds is included. In general, only the most recent results for OB stars are mentioned. (Auth.)

  10. COSMIC ORIGINS SPECTROGRAPH OBSERVATIONS OF TRANSLUCENT CLOUDS: Cyg OB2 8A

    International Nuclear Information System (INIS)

    Snow, Theodore P.; Destree, Joshua D.; Burgh, Eric B.; Ferguson, Ryan M.; Danforth, Charles W.; Cordiner, Martin

    2010-01-01

    Data from the Cosmic Origins Spectrograph (COS) are presented for the first highly reddened target (Cyg OB2 8A) under the COS Science Team's guaranteed time allocation. Column densities of ionic, atomic, and molecular species are reported and implications are discussed. Data from Cyg OB2 8A demonstrate the ability to analyze highly reddened interstellar sight lines with the COS that were unavailable to previous UV instruments. Measured column densities indicate that the Cyg OB2 8A line of sight contains multiple diffuse clouds rather than a dominant translucent cloud.

  11. New Parallaxes for the Upper Scorpius OB Association

    Science.gov (United States)

    Donaldson, J. K.; Weinberger, A. J.; Gagné, J.; Boss, A. P.; Keiser, S. A.

    2017-11-01

    Upper Scorpius is a subgroup of the nearest OB association, Scorpius-Centaurus. Its young age makes it an important association to study star and planet formation. We present parallaxes to 52 low-mass stars in Upper Scorpius, 28 of which have full kinematics. We measure ages of the individual stars by combining our measured parallaxes with pre-main-sequence evolutionary tracks. We find a significant difference in the ages of stars with and without circumstellar disks. The stars without disks have a mean age of 4.9 ± 0.8 Myr and those with disks have an older mean age of 8.2 ± 0.9 Myr. This somewhat counterintuitive result suggests that evolutionary effects in young stars can dominate their apparent ages. We also attempt to use the 28 stars with full kinematics (I.e., proper motion, radial velocity (RV), and parallax) to trace the stars back in time to their original birthplace to obtain a trackback age. As expected, given the large measurement uncertainties on available RV measurements, we find that measurement uncertainties alone cause the group to diverge after a few Myr.

  12. Study of clumping in the Cepheus OB 3 molecular cloud

    International Nuclear Information System (INIS)

    Carr, J.S.

    1987-01-01

    A portion of the Cep OB 3 molecular cloud has been mapped in the (C-13)O (1-0) line on a completely sampled grid with a 1.5-arcmin spacing. A total of 45 individual clouds, or clumps, have been identified in the map, with masses from 3 to 300 solar mass, sizes 3 pc or smaller, and mean densities of a few hundred/cu cm. Power-law correlations are found among the clump properties, namely, M proportional to R exp 2.5 and Delta(v) exp 0.24. These exponents differ somewhat from those found for similar correlations for molecular clouds in previous studies. Determination of the virial masses for the clumps shows that the clumps are not gravitationally bound and must be expanding on a time scale of about 1 Myr. Measurements of the (C-13)O (2-1) line give volume densities of 2000-5000. Comparisons of these densities with the mean volume densities from the (C-13)O (1-0) data suggest that the gas is clumped on a small scale with a volume filling factor of 0.04-0.10. 31 references

  13. A Novel Congestion Detection Scheme in TCP Over OBS Networks

    KAUST Repository

    Shihada, Basem

    2009-02-01

    This paper introduces a novel congestion detection scheme for high-bandwidth TCP flows over optical burst switching (OBS) networks, called statistical additive increase multiplicative decrease (SAIMD). SAIMD maintains and analyzes a number of previous round-trip time (RTTs) at the TCP senders in order to identify the confidence with which a packet loss event is due to network congestion. The confidence is derived by positioning short-term RTT in the spectrum of long-term historical RTTs. The derived confidence corresponding to the packet loss is then taken in the developed policy for TCP congestion window adjustment. We will show through extensive simulation that the proposed scheme can effectively solve the false congestion detection problem and significantly outperform the conventional TCP counterparts without losing fairness. The advantages gained in our scheme are at the expense of introducing more overhead in the SAIMD TCP senders. Based on the proposed congestion control algorithm, a throughput model is formulated, and is further verified by simulation results.

  14. Influences of obese (ob/ob and diabetes (db/db genotype mutations on lumber vertebral radiological and morphometric indices: Skeletal deformation associated with dysregulated systemic glucometabolism

    Directory of Open Access Journals (Sweden)

    Garris David R

    2006-02-01

    Full Text Available Abstract Background Both diabetes and obesity syndromes are recognized to promote lumbar vertebral instability, premature osteodegeneration, exacerbate progressive osteoporosis and increase the propensity towards vertebral degeneration, instability and deformation in humans. Methods The influences of single-gene missense mutations, expressing either diabetes (db/db or obese (ob/ob metabolic syndromes on vertebral maturation and development in C57BL/KsJ mice were evaluated by radiological and macro-morphometric analysis of the resulting variances in osteodevelopment indices relative to control parameters between 8 and 16 weeks of age (syndrome onset @ 4 weeks, and the influences of low-dose 17-B-estradiol therapy on vertebral growth expression evaluated. Results Associated with the indicative genotypic obesity and hyper-glycemic/-insulinemic states, both db/db and ob/ob mutants demonstrated a significant (P ≤ 0.05 elongation of total lumbar vertebrae column (VC regional length, and individual lumbar vertebrae (LV1-5 lengths, relative to control VC and LV parameters. In contrast, LV1-5 width indices were suppressed in db/db and ob/ob mutants relative to control LV growth rates. Between 8 and 16 weeks of age, the suppressed LV1-5 width indices were sustained in both genotype mutant groups relative to control osteomaturation rates. The severity of LV1-5 width osteosuppression correlated with the severe systemic hyperglycemic and hypertriglyceridemic conditions sustained in ob/ob and db/db mutants. Low-dose 17-B-estradiol therapy (E2-HRx: 1.0 ug/ 0.1 ml oil s.c/3.5 days, initiated at 4 weeks of age (i.e., initial onset phase of db/db and ob/ob expressions re-established control LV 1–5 width indices without influencing VC or LV lengths in db/db groups. Conclusion These data demonstrate that the abnormal systemic endometabolic states associated with the expression of db/db and ob/ob genomutation syndromes suppress LV 1–5 width osteomaturation

  15. Expression of the P2X2 receptor in different classes of ileum myenteric neurons in the female obese ob/ob mouse

    Science.gov (United States)

    Mizuno, Márcia Sanae; Crisma, Amanda Rabello; Borelli, Primavera; Castelucci, Patricia

    2012-01-01

    AIM: To examine whether the ob/ob mouse model of obesity is accompanied by enteric nervous system abnormalities such as altered motility. METHODS: The study examined the distribution of the P2X2 receptor (P2X2R) in myenteric neurons of female ob/ob mice. Specifically, we used immunohistochemistry to analyze the co-expression of the P2X2R with neuronal nitric oxide synthase (nNOS), choline acetyltransferase (ChAT), and calretinin (CalR) in neurons of the small intestine myenteric plexus in ob/ob and control female mice. In these sections, we used scanning confocal microscopy to analyze the co-localization of these markers as well as the neuronal density (cm2) and area profile (μm²) of P2X2R-positive neurons. In addition, enteric neurons were labeled using the nicotinamide adenine dinucleotide (NADH) diaphorase method and analyzed with light microscopy as an alternate means by which to analyze neuronal density and area. RESULTS: In the present study, we observed a 29.6% increase in the body weight of the ob/ob animals (OG) compared to the control group (CG). In addition, the average small intestine area was increased by approximately 29.6% in the OG compared to the CG. Immunoreactivity (IR) for the P2X2R, nNOS, ChAT and CalR was detectable in the myenteric plexus, as well as in the smooth muscle, in both groups. This IR appeared to be mainly cytoplasmic and was also associated with the cell membrane of the myenteric plexus neurons, where it outlined the neuronal cell bodies and their processes. P2X2R-IR was observed to co-localize 100% with that for nNOS, ChAT and CalR in neurons of both groups. In the ob/ob group, however, we observed that the neuronal density (neuron/cm2) of P2X2R-IR cells was increased by 62% compared to CG, while that of NOS-IR and ChAT-IR neurons was reduced by 49% and 57%, respectively, compared to control mice. The neuronal density of CalR-IR neurons was not different between the groups. Morphometric studies further demonstrated that the

  16. Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice.

    Science.gov (United States)

    Huang, S-L; Yu, R-T; Gong, J; Feng, Y; Dai, Y-L; Hu, F; Hu, Y-H; Tao, Y-D; Leng, Y

    2012-05-01

    Arctigenin is a natural compound that had never been previously demonstrated to have a glucose-lowering effect. Here it was found to activate AMP-activated protein kinase (AMPK), and the mechanism by which this occurred, as well as the effects on glucose and lipid metabolism were investigated. 2-Deoxyglucose uptake and AMPK phosphorylation were examined in L6 myotubes and isolated skeletal muscle. Gluconeogenesis and lipid synthesis were evaluated in rat primary hepatocytes. The acute and chronic effects of arctigenin on metabolic abnormalities were observed in C57BL/6J and ob/ob mice. Changes in mitochondrial membrane potential were measured using the J-aggregate-forming dye, JC-1. Analysis of respiration of L6 myotubes or isolated mitochondria was conducted in a channel oxygen system. Arctigenin increased AMPK phosphorylation and stimulated glucose uptake in L6 myotubes and isolated skeletal muscles. In primary hepatocytes, it decreased gluconeogenesis and lipid synthesis. The enhancement of glucose uptake and suppression of hepatic gluconeogenesis and lipid synthesis by arctigenin were prevented by blockade of AMPK activation. The respiration of L6 myotubes or isolated mitochondria was inhibited by arctigenin with a specific effect on respiratory complex I. A single oral dose of arctigenin reduced gluconeogenesis in C57BL/6J mice. Chronic oral administration of arctigenin lowered blood glucose and improved lipid metabolism in ob/ob mice. This study demonstrates a new role for arctigenin as a potent indirect activator of AMPK via inhibition of respiratory complex I, with beneficial effects on metabolic disorders in ob/ob mice. This highlights the potential value of arctigenin as a possible treatment of type 2 diabetes.

  17. [Detection of psychosocial dysfunction in ob-gyn patients].

    Science.gov (United States)

    González-Forteza, C F; Morales Carmona, F; Gutiérrez Calderon, E

    1993-01-01

    The human behavior and its social determinants are critical variables for understanding the etiology, treatment, and prevention of many disorders previously attributed to biological substrates. Among the many categories of human behavior to receive special attention from health researchers and practitioners are life events, coping responses and emotional state. The relation between these categories constituted a particular field of investigation. This relationship rather than forcing to focus on disease, distress, disability, and other failures in human functioning, permits to address health, abilities, resources, and other positive aspects of human functioning. On the other hand, the re-organization of health services considers interdisciplinary work as an objective, as it is necessary to care for the patient in an integral manner, with the consequent benefit of a more efficient service. In addition it is known that patients with psychosocial dysfunctions who use general practice care facilities overutilize these services in an unnecessary manner. With this in mind it is clear that is necessary to balance the service's cost-benefit for a more efficient clinical attention. In this paper we present the results of the categories mentioned above: life events, coping responses and its relationship with emotional state in a representative sample of 399 female patients who in 1986 received services at the National Institute of Perinatology-INPer-. Of these patients, 297 were obstetrical patients -OBS- and 102 gynaecological ones -GINE-. All patients answered these instruments: General Health Questionnaire -GHQ-7 of 30 items, a subscale of Health and Daily Living for Coping Responses and Life Events Scale.(ABSTRACT TRUNCATED AT 250 WORDS)

  18. A CATALOG OF NEW SPECTROSCOPICALLY CONFIRMED MASSIVE OB STARS IN CARINA

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, Michael J.; Hanes, Richard J.; McSwain, M. Virginia [Department of Physics, Lehigh University, 16 Memorial Drive East, Bethlehem, PA 18015 (United States); Povich, Matthew S., E-mail: alexamic@lafayette.edu, E-mail: rjh314@lehigh.edu, E-mail: mcswain@lehigh.edu, E-mail: mspovich@cpp.edu [Department of Physics and Astronomy, California State Polytechnic University, Pomona, CA 91768 (United States)

    2016-12-01

    The Carina star-forming region is one of the largest in the Galaxy, and its massive star population is still being unveiled. The large number of stars combined with high, and highly variable, interstellar extinction makes it inherently difficult to find OB stars in this type of young region. We present the results of a spectroscopic campaign to study the massive star population of the Carina Nebula, with the primary goal to confirm or reject previously identified Carina OB star candidates. A total of 141 known O- and B-type stars and 94 candidates were observed, of which 73 candidates had high enough signal-to-noise ratio to classify. We find 23 new OB stars within the Carina Nebula, a 32% confirmation rate. One of the new OB stars has blended spectra and is suspected to be a double-lined spectroscopic binary (SB2). We also reclassify the spectral types of the known OB stars and discover nine new SB2s among this population. Finally, we discuss the spatial distribution of these new OB stars relative to known structures in the Carina Nebula.

  19. Radionuclides in the Ob/Irtysh river system and their contribution to pollution of the Arctic

    International Nuclear Information System (INIS)

    Trapeznikov, A.; Pozolotina, V.; Trapeznikova, V.; Yushkov, P.; Polikarpov, G.; Aarkrog, A.; Nielsen, S.P.

    1995-01-01

    The aims of this study were: 1) to continue the investigation of distribution of radionuclides in the principal components of the Techa river, and 2) to get the first estimate of the contamination of sediments of the Iset, Tobol, Irtysh and Ob rivers. The samples from the Irtysh river were collected in 1993 nine km in front of confluence of the Irtysh with the Ob river. The mean Cs-137 concentration in the sediments did not show any clear trend. The sediments from the Ob river were collected in 1992 near Labitnangi, situated about 300 km from the outlet of the Ob into the Kara Sea. In 1994 samples were collected five km in front of and five km after confluence with the Irtysh river. All results are summarized in a table. It appears that the Cs-137 levels in the Ob sediments, before and after confluence with Irtysh, do not change significantly. It is difficult to see any systematic changes in Cs-137 concentrations with depth. In some cases the top five cm show higher concentrations than the deeper layers. 7 refs., 1 tab

  20. Search for OB stars running away from young star clusters. I. NGC 6611

    Science.gov (United States)

    Gvaramadze, V. V.; Bomans, D. J.

    2008-11-01

    N-body simulations have shown that the dynamical decay of the young (~1 Myr) Orion Nebula cluster could be responsible for the loss of at least half of its initial content of OB stars. This result suggests that other young stellar systems could also lose a significant fraction of their massive stars at the very beginning of their evolution. To confirm this expectation, we used the Mid-Infrared Galactic Plane Survey (completed by the Midcourse Space Experiment satellite) to search for bow shocks around a number of young (⪉several Myr) clusters and OB associations. We discovered dozens of bow shocks generated by OB stars running away from these stellar systems, supporting the idea of significant dynamical loss of OB stars. In this paper, we report the discovery of three bow shocks produced by O-type stars ejected from the open cluster NGC 6611 (M16). One of the bow shocks is associated with the O9.5Iab star HD165319, which was suggested to be one of “the best examples for isolated Galactic high-mass star formation” (de Wit et al. 2005, A&A, 437, 247). Possible implications of our results for the origin of field OB stars are discussed.

  1. Production of metal and metal-ceramic coatings on D-Gun Ob

    International Nuclear Information System (INIS)

    Gavrilenko, T.P.; Nikolaev, Y.A.; Ulianitsky, V.Y.

    1995-01-01

    Optimization of the detonation spraying process has been made for the production of metal and metal-ceramics coatings with the D-Gun Ob. Owing to the ability of Ob to work with several fuels and an inert diluent simultaneously, variation of detonation regimes in a wide range is possible, and because of localized powder injection in the D-Gun barrel, high uniformity of parameters of powder particles is achieved. The best conditions for particle heating and acceleration were calculated with the help of mathematical simulation, and the corresponding regimes were realized on D-Gun Ob. High-quality aluminum, copper, nickel, and nickel-chromium-silicon-carbon-boron alloy coatings were produced by using only propane fuel. Chromium carbide with nickel and tungsten carbide with cobalt coatings were produced with addition of acetylene. Optimal efficiency and high bonding strength were achieved for all powders. Data on microhardness, bonding strength, and efficiency are presented

  2. The performance study of oxide by-passed(OB) lateral double diffused MOSFET

    Science.gov (United States)

    Tang, Pan-pan

    2016-10-01

    An SOI LDMOS device structure with Oxide By-passed(OB) was investigated and its breakdown mechanism and characteristic of structure was analyzed. Its performance was verified by 3D numerical simulation with SILVACO TCAD software. The simulated results show that the electrical field element of the device is modulated by the concept of similar Superjunction(SJ) structure. Compared with the SJ LDMOS device, OB LDMOS obtains the same breakdown voltage, simultaneously the specific on-resistance of the OB LDMOS reduces from 3.81mΩ·cm2 to 1.96mΩ·cm2, except for achieving comparable performance and overcoming the high aspect ratio of fabrication structure and the difficulty of accurate concentration match of SJ LDMOS.

  3. ESTIMATION OF BURSTS LENGTH AND DESIGN OF A FIBER DELAY LINE BASED OBS ROUTER

    Directory of Open Access Journals (Sweden)

    RICHA AWASTHI

    2017-03-01

    Full Text Available The demand for higher bandwidth is increasing day by day and this ever growing demand cannot be catered to with current electronic technology. Thus new communication technology like optical communication needs to be used. In the similar context OBS (optical burst switching is considered as next generation data transfer technology. In OBS information is transmitted in forms of optical bursts of variable lengths. However, contention among the bursts is a major problem in OBS system, and for contention resolution defection routing is mostly preferred. However, deflection routing increases delay. In this paper, it is shown that the arrival of very large bursts is rare event, and for moderate burst length the buffering of contending burst can provide very effective solution. However, in case of arrival of large bursts deflection can be used.

  4. The OB run-away stars from Sco-Cen and Orion reviewed

    International Nuclear Information System (INIS)

    Blaauw, A.

    1989-01-01

    The author studies the past paths of the run-away star Zeta Oph from the OB association Sco-Cen, and of the run-away stars AE Aur, Mu Col and 53 Ari from the OB association Ori OB1, in connection with the question of the origin of these high velocities. Should the binary-hypothesis be adhered to (supernova explosion of one of the components) or, perhaps, dynamical evolution in young, dense clusters offer a clue to this phenomenon? It is shown that the latter hypothesis is very unlikely to apply to Zeta Oph. For the run-away stars from Orion conclusive evidence may well be obtained in the course of the next decade, from improved accuracy of the proper motions

  5. Transcriptional activation of the mouse obese (ob) gene by CCAAT/enhancer binding protein alpha

    DEFF Research Database (Denmark)

    Hwang, C S; Mandrup, S; MacDougald, O A

    1996-01-01

    Like other adipocyte genes that are transcriptionally activated by CCAAT/enhancer binding protein alpha (C/EBP alpha) during preadipocyte differentiation, expression of the mouse obese (ob) gene is immediately preceded by the expression of C/EBP alpha. While the 5' flanking region of the mouse ob...... gene contains several consensus C/EBP binding sites, only one of these sites appears to be functional. DNase I cleavage inhibition patterns (footprinting) of the ob gene promoter revealed that recombinant C/EBP alpha, as well as a nuclear factor present in fully differentiated 3T3-L1 adipocytes...... to a consensus C/EBP binding site at nucleotides -55 to -47 generated a specific protein-oligonucleotide complex that was supershifted by antibody against C/EBP alpha. Probes corresponding to two upstream consensus C/EBP binding sites failed to generate protein-oligonucleotide complexes. Cotransfection of a C...

  6. NEAR INFRARED DIFFUSE INTERSTELLAR BANDS TOWARD THE CYGNUS OB2 ASSOCIATION

    Energy Technology Data Exchange (ETDEWEB)

    Hamano, Satoshi; Kondo, Sohei; Sameshima, Hiroaki; Nakanishi, Kenshi; Kawakita, Hideyo [Laboratory of Infrared High-resolution Spectroscopy, Koyama Astronomical Observatory, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555 (Japan); Kobayashi, Naoto [Institute of Astronomy, School of Science, University of Tokyo, 2-21-1 Osawa, Mitaka, Tokyo 181-0015 (Japan); Ikeda, Yuji [Photocoding, 460-102 Iwakura-Nakamachi, Sakyo-ku, Kyoto, 606-0025 (Japan); Yasui, Chikako; Mizumoto, Misaki; Matsunaga, Noriyuki; Fukue, Kei; Yamamoto, Ryo; Izumi, Natsuko [Department of Astronomy, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan); Mito, Hiroyuki [Kiso Observatory, Institute of Astronomy, School of Science, The University of Tokyo, 10762-30 Mitake, Kiso-machi, Kiso-gun, Nagano, 397-0101 (Japan); Nakaoka, Tetsuya; Kawanishi, Takafumi; Kitano, Ayaka; Otsubo, Shogo [Department of Physics, Faculty of Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555 (Japan); Kinoshita, Masaomi, E-mail: hamano@cc.kyoto-su.ac.jp [Solar-Terrestrial Environment Laboratory, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-8601 (Japan)

    2016-04-10

    We obtained the near-infrared (NIR) high-resolution (R ≡ λ/Δλ ∼ 20,000) spectra of the seven brightest early-type stars in the Cygnus OB2 association for investigating the environmental dependence of diffuse interstellar bands (DIBs). The WINERED spectrograph mounted on the Araki 1.3 m telescope in Japan was used to collect data. All 20 of the known DIBs within the wavelength coverage of WINERED (0.91 < λ < 1.36 μm) were clearly detected along all lines of sight because of their high flux density in the NIR wavelength range and the large extinction. The equivalent widths (EWs) of DIBs were not correlated with the column densities of C{sub 2} molecules, which trace the patchy dense component, suggesting that the NIR DIB carriers are distributed mainly in the diffuse component. On the basis of the correlations among the NIR DIBs both for stars in Cyg OB2 and stars observed previously, λλ10780, 10792, 11797, 12623, and 13175 are found to constitute a “family,” in which the DIBs are correlated well over the wide EW range. In contrast, the EW of λ10504 is found to remain almost constant over the stars in Cyg OB2. The extinction estimated from the average EW of λ10504 (A{sub V} ∼ 3.6 mag) roughly corresponds to the lower limit of the extinction distribution of OB stars in Cyg OB2. This suggests that λ10504 is absorbed only by the foreground clouds, implying that the carrier of λ10504 is completely destroyed in Cyg OB2, probably by the strong UV radiation field. The different behaviors of the DIBs may be caused by different properties of the DIB carriers.

  7. Magnetic field of massive chemically peculiar stars in the Orion OB1 association

    Science.gov (United States)

    Romanyuk, I. I.; Semenko, E. A.; Kudryavtsev, D. O.; Yakunin, I. A.

    2018-01-01

    Spectropolarimetric observations of 55 chemically peculiar stars in the Orion OB1 association were obtained at the 6 m telescope of the Russian Academy of Sciences with the aim of searching for the presence of stellar magnetic fields. We found 8 new magnetic stars in addition to 20 previously known objects. The frequency of chemically peculiar A and B-type stars among normal A and B-type stars and the frequency of magnetic stars among all chemically peculiar stars decreases with age in the Orion OB1 association.

  8. Analyzing the Effects of Nitrogen Deficiency on the PHB Production of Methylosinus trichosporium OB3b

    Science.gov (United States)

    Kyauk, E.

    2011-12-01

    Polyhydroxybutyrate (PHB) is a biodegradable thermoplastic that is produced by various microorganisms. Because of its potential to replace conventional plastics, it has been closely researched in the past few years. Methanotrophic bacteria, bacteria that consume methane, produce this bioplastic when it lacks certain nutrients. The utilization of methane to produce PHB shows much promise as methane is a cheap, plentiful gas. In this study, we observed the methanotroph, Methylosinus trichosporium OB3b , and its yield of PHB in the absence of nitrogen. The optical density of Methylosinus trichosporium OB3b was measured in order to observe cell growth and PHB production patterns over a 48 hour period.

  9. A Method of Identification and Inspection for Inventory Control of Irradiated Fuel Elements; Methode d'Identification et d'Inspection Permettant de Proceder a l'Inventaire des Elements Combustibles Irradies; Metod identifikatsii i proverki pri inventarnom kontrole obluchennykh toplivnykh ehlementov; Metodos de Identificacion e Inspeccion para el Control de las Existencias de Elementos Combustibles Irradiados

    Energy Technology Data Exchange (ETDEWEB)

    Kinderman, E. M.; Mills, J. S. [Stanford Research Institute, Menlo Park, CA (United States)

    1966-02-15

    neobhodimo proverjat' pri ljuboj polnoj inventarnoj proverke special'nyh jadernyh materialov. Jeto, odnako, svjazano s osobymi trudnostjami s tochki zrenija fiziki, s kotorymi .stalkivaetsja kontroler'ili rukovoditel' operacii po provedeniju inventarnogo kontrolja. V jetih mestah rasstojanie mezhdu ob{sup e}ktom i nabljudatelem i plohoe osveshhenie i iskazhenie sveta, vyzyvaemoe sredoj zashhity (voda, svincovoe steklo), delajut provedenie inventarnoj proverki eshhe bolee trudnoj. Chtoby preodolet' jeti trudnosti i sozdat' sistemu, kotoraja oblegchit opoznavanie vygruzhaemogo topliva iz reaktora, razrabotana kompaktnaja i udobnaja sistema opticheskoj proverki s primeneniem nepodvizhnoj stancii proverki, periskopa, teleskopa i kamery. Jeta sistema proverena v bassejne dlja obluchenija kobal'ta putem izuchenija probnyh obrazcov s razlichnoj markirovkoj, kotorye obrabatyvali v petle s gorjachej cirkulirujushhej vodoj. V sisteme proverki primenjali napolnennyj vodoj periskop dlinoju 11 futov, katadioptricheskij teleskop, raspolozhennyj v 16 futah ot periskopa, i 35 mm kameru dlja registracii nabljudenij. Teleskop, kamera i sborki vsegda mozhno peredvinut', poskol'ku oni vse vmeste vesjat menee 22 funtov i imejut maksimal'nyj razmer 29 djujmov. Fotograficheskie nabljudenija za proverochnymi tablicami razreshenija v vozduhe na rasstojanii 20 futov ot linzy ob{sup e}ktiva teleskopa pokazali, chto sistema mozhet davat' razreshenie 22 mikrona v shirinu. Jeto sootvetstvuet razresheniju 0,8 sek dugi. Predvaritel'nye ispytanija, provedennye s vodnoj sistemoj, pokazali, chto razreshajushhaja sposobnost' jetoj sistemy na rasstojanii 20 futov luchshe 50 mikron. Jeto sootvetstvuet razresheniju priblizitel'no 1 sek dugi. Jasno, odnako, chto razreshajushhaja sposobnost' vodnoj sistemy nikogda ne mozhet byt' luchshe vozdushnoj. V ljubom sluchae nyneshnjaja sistema, primenjaemaja pri inventarnoj proverke topliva, dolzhna nadlezhashhim obrazom vosproizvodit' ljubye inventarnye otmetki. (author)

  10. Advective transport observations with MODPATH-OBS--documentation of the MODPATH observation process

    Science.gov (United States)

    Hanson, R.T.; Kauffman, L.K.; Hill, M.C.; Dickinson, J.E.; Mehl, S.W.

    2013-01-01

    The MODPATH-OBS computer program described in this report is designed to calculate simulated equivalents for observations related to advective groundwater transport that can be represented in a quantitative way by using simulated particle-tracking data. The simulated equivalents supported by MODPATH-OBS are (1) distance from a source location at a defined time, or proximity to an observed location; (2) time of travel from an initial location to defined locations, areas, or volumes of the simulated system; (3) concentrations used to simulate groundwater age; and (4) percentages of water derived from contributing source areas. Although particle tracking only simulates the advective component of conservative transport, effects of non-conservative processes such as retardation can be approximated through manipulation of the effective-porosity value used to calculate velocity based on the properties of selected conservative tracers. This program can also account for simple decay or production, but it cannot account for diffusion. Dispersion can be represented through direct simulation of subsurface heterogeneity and the use of many particles. MODPATH-OBS acts as a postprocessor to MODPATH, so that the sequence of model runs generally required is MODFLOW, MODPATH, and MODPATH-OBS. The version of MODFLOW and MODPATH that support the version of MODPATH-OBS presented in this report are MODFLOW-2005 or MODFLOW-LGR, and MODPATH-LGR. MODFLOW-LGR is derived from MODFLOW-2005, MODPATH 5, and MODPATH 6 and supports local grid refinement. MODPATH-LGR is derived from MODPATH 5. It supports the forward and backward tracking of particles through locally refined grids and provides the output needed for MODPATH_OBS. For a single grid and no observations, MODPATH-LGR results are equivalent to MODPATH 5. MODPATH-LGR and MODPATH-OBS simulations can use nearly all of the capabilities of MODFLOW-2005 and MODFLOW-LGR; for example, simulations may be steady-state, transient, or a combination

  11. [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, small molecule synthetic peptide leptin mimetics, improve glycemic control in diet-induced obese (DIO) mice.

    Science.gov (United States)

    Wang, Anke; Anderson, Brian M; Novakovic, Zachary M; Grasso, Patricia

    2018-03-01

    We have previously shown that following oral delivery in dodecyl maltoside (DDM), [D-Leu-4]-OB3 and its myristic acid conjugate, MA-[D-Leu-4]-OB3, improved energy balance and glucose homeostasis in genetically obese/diabetic mouse models. More recently, we have provided immunohistochemical evidence indicating that these synthetic peptide leptin mimetics cross the blood-brain barrier and concentrate in the area of the arcuate nucleus of the hypothalamus in normal C57BL/6J and Swiss Webster mice, in genetically obese ob/ob mice, and in diet-induced obese (DIO) mice. In the present study, we describe the effects of oral delivery of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3 on glycemic control in diet-induced (DIO) mice, a non-genetic rodent model of obesity and its associated insulin resistance, which more closely recapitulates common obesity and diabetes in humans. Male C57BL/6J and DIO mice, 17, 20, and 28 weeks of age, were maintained on a low-fat or high-fat diet and given vehicle (DDM) alone or [D-Leu-4]-OB3 or MA-[D-Leu-4]-OB3 in DDM by oral gavage for 12 or 14 days. Body weight gain, food and water intake, fasting blood glucose, oral glucose tolerance, and serum insulin levels were measured. Our data indicate that (1) [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3 restore glucose tolerance in male DIO mice maintained on a high-fat diet to levels comparable to those of non-obese C57BL/6J wild-type mice of the same age and sex maintained on a low-fat diet; and (2) the influence of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3 on glycemic control appears to be independent of their effects on energy balance. These results suggest that [D-Leu-4]-OB3 and/or MA-[D-Leu-4]-OB3 may have application to the management of the majority of cases of common obesity in humans, a state characterized at least in part, by leptin resistance resulting from a defect in leptin transport across the blood-brain barrier. They further suggest that these small molecule synthetic peptide leptin mimetics, through their

  12. Conversion of chlorinated propanes by Methylosinus trichosporium OB3b expressing soluble methane monooxygenase

    NARCIS (Netherlands)

    Bosma, T.; Janssen, D.B.

    Chlorinated propanes are important pollutants that may show persistent behaviour in the environment. The biotransformation of 1-chloropropane, 1,2-dichloropropane, 1,3-dichloropropane and 1,2,3-trichloropropane was studied using resting cell suspensions of Methylosinus trichosporium OB3b expressing

  13. Formation of massive stars in OB associations and giant molecular clouds

    International Nuclear Information System (INIS)

    Lada, C.J.

    1980-01-01

    Certain interesting patterns are being perceived in the morphology of the regions which have recently produced massive OB stars. In particular, current evidence seems to favour the notion that the formation of massive stars takes place at the edges and not the centres of large molecular cloud complexes. It is this aspect of the observations that is discussed in the present paper. The phenomena described here will pertain to massive stars only. Specifically, stars with spectral types earlier than B3 will be considered since it is usually only these stars that produce sufficient havoc (e.g., maser sources, CO bright spots, H II regions) to noticeably affect their early environments. The corresponding phenomena for lower mass stars could be entirely different. A review is first presented of what has been learned about the OB star formation process from studies of the visible OB stars themselves. Then, newly derived information pertaining to the most recent episodes of OB star birth in galactic molecular clouds is discussed. Finally, a short discussion of the significance of the results and their implications for possible star formation mechanisms will be made. (U.K.)

  14. Degradation of Chlorinated Aliphatic Hydrocarbons by Methylosinus trichosporium OB3b Expressing Soluble Methane Monooxygenase

    NARCIS (Netherlands)

    Oldenhuis, R.; Vink, Ruud L.J.M.; Janssen, D. B.; Witholt, B.

    1989-01-01

    Degradation of trichloroethylene (TCE) by the methanotrophic bacterium Methylosinus trichosporium OB3b was studied by using cells grown in continuous culture. TCE degradation was a strictly cometabolic process, requiring the presence of a cosubstrate, preferably formate, and oxygen. M. trichosporium

  15. Inter-Division IV/V WG on Active OB Stars

    NARCIS (Netherlands)

    Owocki, S.; Aerts, C.; Fabregat, J.; Gies, D.; Henrichs, H.F.; McDavid, D.; Porter, J.; Rivinius, T.; Peters, G.; Stefl, S.

    2007-01-01

    Our group studies active early-type (OB) stars, with historical focus on classical Be stars, but extending in recent years to include Slowly Pulsating B-stars (SPB), Beta-Cephei stars, the strongly magnetic Bp stars, Luminous Blue Vairiable (LBV) stars, and B[e] stars. An overall goal is to

  16. Kinetics of Chlorinated Hydrocarbon Degradation by Methylosinus trichosporium OB3b and Toxicity of Trichloroethylene

    NARCIS (Netherlands)

    Oldenhuis, Roelof; Oedzes, Johannes Y.; Waarde, Jacob J. van der; Janssen, Dick B.

    The kinetics of the degradation of trichloroethylene (TCE) and seven other chlorinated aliphatic hydrocarbons by Methylosinus trichosporium OB3b were studied. All experiments were performed with cells grown under copper stress and thus expressing soluble methane monooxygenase. Compounds that were

  17. VizieR Online Data Catalog: Velocity and proper motion of OB associations (Melnik+, 2009)

    Science.gov (United States)

    Melnik, A. M.; Dambis, A. K.

    2009-11-01

    For every OB-association from the list by Blaha and Humphreys (1989AJ.....98.1598B) we give the mean galactic coordinates l and b, the mean heliocentric distance r, median line-of-sight velocity Vr, the dispersion of line-of-sight velocities dvr, and number of stars with known line-of-sight velocity nvr. The line-of-sight velocities were taken from the catalog by Barbier-Brossat and Figon (1999, Cat. ). We used only the velocities measured with errors of less than 10km/s which corresponds to the quality estimations A, B, and C. We also present median proper motions of OB-associations along l- and b- coordinates, mul and mub. The data obtained for the old reduction (1997, Cat. ) are denoted by the subscript 1, whereas those based on the reduction by van Leewen (2008, Cat. ) are marked by the subscript 2. For each OB association we represent the dispersions of proper motions, dml and dmb, as well as a number of stars nmu with known proper motion. The last column shows the total number of stars with known photometric measurements, Nt, used for determination of the distances for OB-associations. The distances r correspond to the short distance scale for classical Cepheids. They are equal to the distances from the catalog by Blaha and Humphreys (1989AJ.....98.1598B), rBH, multiplied by a factor of 0.8, r=0.8*rBH. (1 data file).

  18. High rate of vaginal erosions associated with the mentor ObTape.

    Science.gov (United States)

    Yamada, Brian S; Govier, Fred E; Stefanovic, Ksenija B; Kobashi, Kathleen C

    2006-08-01

    The transobturator tape method is a newer surgical technique for the treatment of stress urinary incontinence. Limited data exist related to complications with this approach or the types of mesh products used. We report our experience with vaginal erosions associated with the Mentor ObTape and American Medical Systems Monarc transobturator slings. Beginning in December 2003 selected female patients with anatomic urinary incontinence were prospectively followed after placement of the Mentor ObTape. Beginning in January 2004 we also began using the American Medical Systems Monarc in similar patients. Patients were admitted overnight after surgery, discharged on oral antibiotics, and seen in the clinic at 6 weeks postoperatively. A total of 67 patients have undergone placement of the Mentor ObTape and 9 of those patients (13.4%) have had vaginal extrusions of the sling. Eight patients reported a history of persistent vaginal discharge. One patient presented initially to an outside facility with a left thigh abscess tracking to the left inguinal incision site. Each patient was taken back to the operating room for mesh removal. A total of 56 patients have undergone placement of the AMS Monarc and none have had any vaginal erosions. Our high rate of vaginal extrusion using the ObTape has led us to discontinue the use of this product in our institution. Continued followup of all of these patients will be of critical importance.

  19. ObsPack: a framework for the preparation, delivery, and attribution of atmospheric greenhouse gas data

    NARCIS (Netherlands)

    Masarie, K. A.; Peters, W.; Jacobson, A. R.; Tans, P. P.

    2014-01-01

    Observation Package (ObsPack) is a framework designed to bring together atmospheric greenhouse gas observations from a variety of sampling platforms, prepare them with specific applications in mind, and package and distribute them in a self-consistent and well-documented product. Data products

  20. ObsPack: a framework for the preparation, delivery, and attribution of atmospheric greenhouse gas measurements

    NARCIS (Netherlands)

    Masarie, K. A.; Peters, W.; Jacobson, A. R.; Tans, P. P.

    2014-01-01

    Observation Package (ObsPack) is a framework designed to bring together atmospheric greenhouse gas observations from a variety of sampling platforms, prepare them with specific applications in mind, and package and distribute them in a self-consistent and well-documented product. Data products

  1. Effect of chlorinated ethene conversion on viability and activity of Methylosinus trichosporium OB3b

    NARCIS (Netherlands)

    van Hylckama Vlieg, Johan E.T.; Koning, Wim de; Janssen, Dick B.

    1997-01-01

    The effect of transformation of chlorinated ethenes on the cell viability of Methylosinus trichosporium OB3b was investigated. A comparison of the loss of viability with the decrease in transformation rates shelved that for the monooxygenase-mediated transformation of all chlorinated ethenes except

  2. Analytical model of a burst assembly algorithm for the VBR in the OBS networks

    International Nuclear Information System (INIS)

    Shargabi, M.A.A.; Mellah, H.; Abid, A.

    2008-01-01

    This paper presents a proposed analytical model for the number of bursts aggregated in a period of time in OBS networks. The model considers the case of VBR traffic with two different sending rates, which are SCR and PCR. The model is validated using extensive simulations. Where results from simulations are in total agreement with the results obtained by the proposed model. (author)

  3. Mass loss from OB supergiants in x-ray binary systems

    International Nuclear Information System (INIS)

    Alme, M.L.; Wilson, J.R.

    1975-01-01

    A study of the atmospheres of OB supergiants in x-ray binary systems indicates that when the stellar surface is close enough to the saddle in the gravitational potential to provide a mass transfer rate adequate to power a compact x-ray source, large-amplitude variations in the rate of mass flow occur. 9 references

  4. BOREAS TF-3 NSA-OBS Tower Flux, Meteorological, and Soil Temperature Data

    Science.gov (United States)

    Wofsy, Steven; Sutton, Doug; Goulden, Mike; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux (BOREAS TF-3) team collected tower flux, surface meteorological, and soil temperature data at the BOREAS Northern Study Area-Old Black Spruce (NSA-OBS) site continuously from the March 1994 through October 1996. The data are available in tabular ASCII files.

  5. The Overt Behaviour Scale-Self-Report (OBS-SR) for acquired brain injury: exploratory analysis of reliability and validity.

    Science.gov (United States)

    Kelly, Glenn; Simpson, Grahame K; Brown, Suzanne; Kremer, Peter; Gillett, Lauren

    2017-05-23

    The objectives were to test the properties, via a psychometric study, of the Overt Behaviour Scale-Self-Report (OBS-SR), a version of the OBS-Adult Scale developed to provide a client perspective on challenging behaviours after acquired brain injury. Study sample 1 consisted of 37 patients with primary brain tumour (PBT) and a family-member informant. Sample 2 consisted of 34 clients with other acquired brain injury (mixed brain injury, MBI) and a service-provider informant. Participants completed the OBS-SR (at two time points), and the Awareness Questionnaire (AQ) and Mayo Portland Adaptability Inventory-III (MPAI-III) once; informants completed the OBS-Adult and AQ once only. PBT-informant dyads displayed "good" levels of agreement (ICC 2,k  = .74; OBS-SR global index). Although MBI-informant dyads displayed no agreement (ICC 2,k  = .22; OBS-SR global index), the sub-group (17/29) rated by clinicians as having moderate to good levels of awareness displayed "fair" agreement (ICC 2,k  = .58; OBS-SR global index). Convergent/divergent validity was demonstrated by significant correlations between OBS-SR subscales and MPAI-III subscales with behavioural content (coefficients in the range .36 -.61). Scores had good reliability across one week (ICC 2,k  = .69). The OBS-SR took approximately 15 minutes to complete. It was concluded that the OBS-SR demonstrated acceptable reliability and validity, providing a useful resource in understanding clients' perspectives about their behaviour.

  6. ObsPy: A Python toolbox for seismology - Sustainability, New Features, and Applications

    Science.gov (United States)

    Krischer, L.; Megies, T.; Sales de Andrade, E.; Barsch, R.; MacCarthy, J.

    2016-12-01

    ObsPy (https://www.obspy.org) is a community-driven, open-source project dedicated to offer a bridge for seismology into the scientific Python ecosystem. Amongst other things, it provides Read and write support for essentially every commonly used data format in seismology with a unified interface. This includes waveform data as well as station and event meta information. A signal processing toolbox tuned to the specific needs of seismologists. Integrated access to the largest data centers, web services, and databases. Wrappers around third party codes like libmseed and evalresp. Using ObsPy enables users to take advantage of the vast scientific ecosystem that has developed around Python. In contrast to many other programming languages and tools, Python is simple enough to enable an exploratory and interactive coding style desired by many scientists. At the same time it is a full-fledged programming language usable by software engineers to build complex and large programs. This combination makes it very suitable for use in seismology where research code often must be translated to stable and production ready environments, especially in the age of big data. ObsPy has seen constant development for more than six years and enjoys a large rate of adoption in the seismological community with thousands of users. Successful applications include time-dependent and rotational seismology, big data processing, event relocations, and synthetic studies about attenuation kernels and full-waveform inversions to name a few examples. Additionally it sparked the development of several more specialized packages slowly building a modern seismological ecosystem around it. We will present a short overview of the capabilities of ObsPy and point out several representative use cases and more specialized software built around ObsPy. Additionally we will discuss new and upcoming features, as well as the sustainability of open-source scientific software.

  7. Structure-function analysis of the OB and latch domains of chlorella virus DNA ligase.

    Science.gov (United States)

    Samai, Poulami; Shuman, Stewart

    2011-06-24

    Chlorella virus DNA ligase (ChVLig) is a minimized eukaryal ATP-dependent DNA sealing enzyme with an intrinsic nick-sensing function. ChVLig consists of three structural domains, nucleotidyltransferase (NTase), OB-fold, and latch, that envelop the nicked DNA as a C-shaped protein clamp. The OB domain engages the DNA minor groove on the face of the duplex behind the nick, and it makes contacts to amino acids in the NTase domain surrounding the ligase active site. The latch module occupies the DNA major groove flanking the nick. Residues at the tip of the latch contact the NTase domain to close the ligase clamp. Here we performed a structure-guided mutational analysis of the OB and latch domains. Alanine scanning defined seven individual amino acids as essential in vivo (Lys-274, Arg-285, Phe-286, and Val-288 in the OB domain; Asn-214, Phe-215, and Tyr-217 in the latch), after which structure-activity relations were clarified by conservative substitutions. Biochemical tests of the composite nick sealing reaction and of each of the three chemical steps of the ligation pathway highlighted the importance of Arg-285 and Phe-286 in the catalysis of the DNA adenylylation and phosphodiester synthesis reactions. Phe-286 interacts with the nick 5'-phosphate nucleotide and the 3'-OH base pair and distorts the DNA helical conformation at the nick. Arg-285 is a key component of the OB-NTase interface, where it forms a salt bridge to the essential Asp-29 side chain, which is imputed to coordinate divalent metal catalysts during the nick sealing steps.

  8. Structure-Function Analysis of the OB and Latch Domains of Chlorella Virus DNA Ligase*

    Science.gov (United States)

    Samai, Poulami; Shuman, Stewart

    2011-01-01

    Chlorella virus DNA ligase (ChVLig) is a minimized eukaryal ATP-dependent DNA sealing enzyme with an intrinsic nick-sensing function. ChVLig consists of three structural domains, nucleotidyltransferase (NTase), OB-fold, and latch, that envelop the nicked DNA as a C-shaped protein clamp. The OB domain engages the DNA minor groove on the face of the duplex behind the nick, and it makes contacts to amino acids in the NTase domain surrounding the ligase active site. The latch module occupies the DNA major groove flanking the nick. Residues at the tip of the latch contact the NTase domain to close the ligase clamp. Here we performed a structure-guided mutational analysis of the OB and latch domains. Alanine scanning defined seven individual amino acids as essential in vivo (Lys-274, Arg-285, Phe-286, and Val-288 in the OB domain; Asn-214, Phe-215, and Tyr-217 in the latch), after which structure-activity relations were clarified by conservative substitutions. Biochemical tests of the composite nick sealing reaction and of each of the three chemical steps of the ligation pathway highlighted the importance of Arg-285 and Phe-286 in the catalysis of the DNA adenylylation and phosphodiester synthesis reactions. Phe-286 interacts with the nick 5′-phosphate nucleotide and the 3′-OH base pair and distorts the DNA helical conformation at the nick. Arg-285 is a key component of the OB-NTase interface, where it forms a salt bridge to the essential Asp-29 side chain, which is imputed to coordinate divalent metal catalysts during the nick sealing steps. PMID:21527793

  9. Photoionization of the diffuse interstellar medium and galactic halo by OB associtations

    Science.gov (United States)

    Dove, James B.; Shull, J. Michael

    1994-01-01

    Assuming smoothly varying H I distributions in te Galactic disk, we have calculated the geometry of diffuse II regions due to OB associations in the Galactic plane. Near the solar circle, OB associations with a Lyman continuum (Lyc) photon luminosity Psi(sub Lyc) = 3.3 x 10(exp 7) cm(exp -2) s(exp -1), produce H II regions that are density bounded in the vertical direction (H II chimneys) allowing Lyc to escape the gaseous disk and penetrate into the Galactic halo. We provide analytic formulae for the Lyc escape fraction as functions of S(sub 0) O-star catalog of Garmany and a new Lyc stellar stellar Lyc stellar flux calibration, we find a production rate of Lyc photons by OB associations within 2.5 kpc of Psi(sub Lyc) = 3.3 x 10(exp 7) cm(exp -2) s(exp -1). Integrating the fraction of Lyc photons that escape the disk over our adopted luminosity function of OB associations, we estimate that approximately 7% of the ionizing photons, or Phi(sub Lyc) = 2.3 x 10(exp 6) cm(exp -2) s(exp -1), escape each side of the H I disk layer and penetrate the diffuse ionized medium ('Reynolds layer'). This flux is sufficient to explain the potoionization of this, although we have not constructed a model for the observed H-alpha emission and pulsar dispersion measures that is fully consistent with the absorption rate of Lyc in the H II layer. Since our quiescent model does not account for the effects of dynamic chimneys and superbubbles, which should enhance Lyc escape, we conclude the O stars are the probable source of ionizing radiation for the Reynolds layer. For a random distribution of OB associations throughout the disk, the Lyc flux is nearly uniform for heights Z is greater than approximately 0.8 kpc above the midplane.

  10. Association of plutonium with sediments from the Ob and Yenisey Rivers and Estuaries

    International Nuclear Information System (INIS)

    Skipperud, Lindis; Brown, Justin; Fifield, L. Keith; Oughton, Deborah H.; Salbu, Brit

    2009-01-01

    The present study applied sequential extraction techniques to investigate the binding and mobility of plutonium (Pu) in sediments from the rivers and estuaries of the Ob and Yenisey. As a study site, the Ob and Yenisey are particularly interesting as both rivers have weapons-grade Pu sources in their catchment areas, including the Russian Pu production and reprocessing plants at Mayak, Tomsk-7 and Krashnoyarsk, and the Semipalantinsk nuclear weapons testing site in Kazakhstan. Plutonium activity and 240 Pu/ 239 Pu ratios were determined using accelerator mass spectrometry (AMS). Sequential extractions showed that between 47 and 80% of the Pu in Yenisey River sediments and 35-53% of the Pu in soils around the Techa River are mobilized with weak oxidising agents, which can indicate that Pu is bound to organic material. In contrast, Pu in Ob and Yenisey Estuarine sediments was more strongly bound, with 60-100% being found in the HNO 3 -extractable fraction. This change in speciation could reflect either that Pu bound to organic material in the Techa and Yenisey River sediments becomes more fixed to the sediments with time, or that organic-bound Pu is mobilized and released to the water when the sediments encounter the more saline water of the Ob and Yenisey estuaries. In general, 240 Pu/ 239 Pu ratios were relatively consistent between different extraction fractions, although, in whole sediments, an increase in ratio was observed with distance from the source. This reflects the increased influence of weapon fallout from catchment runoff within the river systems, as compared to the weapons-grade sources close to the production and reprocessing plants. Knowledge of Pu speciation in the Ob and Yenisey Rivers, and the processes controlling its behaviour in estuarine systems, can improve predictions of its transfer and subsequent environmental impact to Arctic Seas

  11. ObsPy: A Python Toolbox for Seismology - Recent Developments and Applications

    Science.gov (United States)

    Megies, T.; Krischer, L.; Barsch, R.; Sales de Andrade, E.; Beyreuther, M.

    2014-12-01

    ObsPy (http://www.obspy.org) is a community-driven, open-source project dedicated to building a bridge for seismology into the scientific Python ecosystem. It offersa) read and write support for essentially all commonly used waveform, station, and event metadata file formats with a unified interface,b) a comprehensive signal processing toolbox tuned to the needs of seismologists,c) integrated access to all large data centers, web services and databases, andd) convenient wrappers to legacy codes like libtau and evalresp.Python, currently the most popular language for teaching introductory computer science courses at top-ranked U.S. departments, is a full-blown programming language with the flexibility of an interactive scripting language. Its extensive standard library and large variety of freely available high quality scientific modules cover most needs in developing scientific processing workflows. Together with packages like NumPy, SciPy, Matplotlib, IPython, Pandas, lxml, and PyQt, ObsPy enables the construction of complete workflows in Python. These vary from reading locally stored data or requesting data from one or more different data centers through to signal analysis and data processing and on to visualizations in GUI and web applications, output of modified/derived data and the creation of publication-quality figures.ObsPy enjoys a large world-wide rate of adoption in the community. Applications successfully using it include time-dependent and rotational seismology, big data processing, event relocations, and synthetic studies about attenuation kernels and full-waveform inversions to name a few examples. All functionality is extensively documented and the ObsPy tutorial and gallery give a good impression of the wide range of possible use cases.We will present the basic features of ObsPy, new developments and applications, and a roadmap for the near future and discuss the sustainability of our open-source development model.

  12. OBS Data Denoising Based on Compressed Sensing Using Fast Discrete Curvelet Transform

    Science.gov (United States)

    Nan, F.; Xu, Y.

    2017-12-01

    OBS (Ocean Bottom Seismometer) data denoising is an important step of OBS data processing and inversion. It is necessary to get clearer seismic phases for further velocity structure analysis. Traditional methods for OBS data denoising include band-pass filter, Wiener filter and deconvolution etc. (Liu, 2015). Most of these filtering methods are based on Fourier Transform (FT). Recently, the multi-scale transform methods such as wavelet transform (WT) and Curvelet transform (CvT) are widely used for data denoising in various applications. The FT, WT and CvT could represent signal sparsely and separate noise in transform domain. They could be used in different cases. Compared with Curvelet transform, the FT has Gibbs phenomenon and it cannot handle points discontinuities well. WT is well localized and multi scale, but it has poor orientation selectivity and could not handle curves discontinuities well. CvT is a multiscale directional transform that could represent curves with only a small number of coefficients. It provide an optimal sparse representation of objects with singularities along smooth curves, which is suitable for seismic data processing. As we know, different seismic phases in OBS data are showed as discontinuous curves in time domain. Hence, we promote to analysis the OBS data via CvT and separate the noise in CvT domain. In this paper, our sparsity-promoting inversion approach is restrained by L1 condition and we solve this L1 problem by using modified iteration thresholding. Results show that the proposed method could suppress the noise well and give sparse results in Curvelet domain. Figure 1 compares the Curvelet denoising method with Wavelet method on the same iterations and threshold through synthetic example. a)Original data. b) Add-noise data. c) Denoised data using CvT. d) Denoised data using WT. The CvT can well eliminate the noise and has better result than WT. Further we applied the CvT denoise method for the OBS data processing. Figure 2a

  13. Deposition of plutonium isotopes and Cs-137 in sediments of the Ob delta from the beginning of the nuclear age

    International Nuclear Information System (INIS)

    Panteleyev, G.P.; Livingston, H.D.; Sayles, F.L.; Medkova, O.N.

    1995-01-01

    As an approach to an assessment of the transport of artificial radionuclides through the Ob river system towards the arctic Ocean, results are presented from the analyses of a series of sediment cores collected in the Ob delta and estuary in 1994. These cores, collected in areas of sediment accumulation, contain the depositional history at the Ob mouth of substances associated with sediment particles from the whole river system watershed. Several approaches to dating these sediments permitted the development of a chronology for the deposition of plutonium isotopes and Cs-137, following their first introduction to the environment a half century ago. Some preliminary results for I-129 are also presented. 6 figs

  14. Multifunctional Bi2ZnOB2O6 single crystals for second and third order nonlinear optical applications

    International Nuclear Information System (INIS)

    Iliopoulos, K.; Kasprowicz, D.; Majchrowski, A.; Michalski, E.; Gindre, D.; Sahraoui, B.

    2013-01-01

    Bi 2 ZnOB 2 O 6 nonlinear optical single crystals were grown by means of the Kyropoulos method from stoichiometric melt. The second and third harmonic generation (SHG/THG) of Bi 2 ZnOB 2 O 6 crystals were investigated by the SHG/THG Maker fringes technique. Moreover, SHG microscopy studies were carried out providing two-dimensional SHG images as a function of the incident laser polarization. The high nonlinear optical efficiency combined with the possibility to grow high quality crystals make Bi 2 ZnOB 2 O 6 an excellent candidate for photonic applications

  15. Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice.

    Science.gov (United States)

    Kozuka, Chisayo; Shimizu-Okabe, Chigusa; Takayama, Chitoshi; Nakano, Kaku; Morinaga, Hidetaka; Kinjo, Ayano; Fukuda, Kotaro; Kamei, Asuka; Yasuoka, Akihito; Kondo, Takashi; Abe, Keiko; Egashira, Kensuke; Masuzaki, Hiroaki

    2017-11-01

    Our previous works demonstrated that brown rice-specific bioactive substance, γ-oryzanol acts as a chaperone, attenuates exaggerated endoplasmic reticulum (ER) stress in brain hypothalamus and pancreatic islets, thereby ameliorating metabolic derangement in high fat diet (HFD)-induced obese diabetic mice. However, extremely low absorption efficiency from intestine of γ-oryzanol is a tough obstacle for the clinical application. Therefore, in this study, to overcome extremely low bioavailability of γ-oryzanol with super-high lipophilicity, we encapsulated γ-oryzanol in polymer poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (Nano-Orz), and evaluated its metabolically beneficial impact in genetically obese-diabetic ob/ob mice, the best-known severest diabetic model in mice. To our surprise, Nano-Orz markedly ameliorated fuel metabolism with an unexpected magnitude (∼1000-fold lower dose) compared with regular γ-oryzanol. Furthermore, such a conspicuous impact was achievable by its administration once every 2 weeks. Besides the excellent impact on dysfunction of hypothalamus and pancreatic islets, Nano-Orz markedly decreased ER stress and inflammation in liver and adipose tissue. Collectively, nanotechnology-based developments of functional foods oriented toward γ-oryzanol shed light on the novel approach for the treatment of a variety of metabolic diseases in humans.

  16. Further RIOTS4 Characterization of Field OB Stars in the SMC

    Science.gov (United States)

    Oey, M. S.; Barnes, Jesse R.; Paggeot, Kevin J.; Dorigo Jones, John; Castro, Norberto; Simon-Diaz, Sergio; Kratter, Kaitlin M.; Moe, Maxwell; Szymanski, Michal

    2018-06-01

    We present recent results from the Runaways and O-Type Star Spectroscopic Survey of the SMC (RIOTS4), a survey quantifying properties of the field OB stars in the Small Magellanic Cloud (SMC). Based on PSF-fitting photometry and astrometry of OGLE-III I-band images, we quantify the degree of isolation for the target OB stars, classifying them as "tip-of-the-iceberg" stars accompanied by small, sparse, clusters; or as true, isolated field stars. Many of these field stars must be runaways, which we evaluate using GAIA DR2 proper motions. We measure v sin i using the IACOB code Fourier analysis, finding that the bimodal distribution of projected rotation velocities is less pronounced for O stars than early B stars. We examine rotation in relation to relative isolation and runaway status.

  17. BOREAS TF-3 Automated Chamber CO2 Flux Data from the NSA-OBS

    Science.gov (United States)

    Goulden, Michael L.; Crill, Patrick M.; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOReal Ecosystem Atmosphere Study Tower Flux (BOREAS TF-3) and Trace Gas Biogeochemistry (TGB-1) teams collected automated CO2 chamber flux data in their efforts to fully describe the CO2 flux at the Northern Study Area-Old Black Spruce (NSA-OBS) site. This data set contains fluxes of CO2 at the NSA-OBS site measured using automated chambers. In addition to reporting the CO2 flux, it reports chamber air temperature, moss temperature, and light levels during each measurement. The data set covers the period from 23-Sep-1995 through 26-Oct-1995 and from 28-May-1996 through 21-Oct-1996. The data are stored in tabular ASCII files.

  18. Conversion of chlorinated propanes by Methylosinus trichosporium OB3b expressing soluble methane monooxygenase

    OpenAIRE

    Bosma, T.; Janssen, D.B.

    1998-01-01

    Chlorinated propanes are important pollutants that may show persistent behaviour in the environment. The biotransformation of 1-chloropropane, 1,2-dichloropropane, 1,3-dichloropropane and 1,2,3-trichloropropane was studied using resting cell suspensions of Methylosinus trichosporium OB3b expressing soluble methane monooxygenase. The transformation followed first-order kinetics. The rate constants were in the order 1-chloropropane > 1,3-dichloropropane > 1,2-dichloropropane > 1,2,3-trichloropr...

  19. ObStruct: a method to objectively analyse factors driving population structure using Bayesian ancestry profiles.

    Directory of Open Access Journals (Sweden)

    Velimir Gayevskiy

    Full Text Available Bayesian inference methods are extensively used to detect the presence of population structure given genetic data. The primary output of software implementing these methods are ancestry profiles of sampled individuals. While these profiles robustly partition the data into subgroups, currently there is no objective method to determine whether the fixed factor of interest (e.g. geographic origin correlates with inferred subgroups or not, and if so, which populations are driving this correlation. We present ObStruct, a novel tool to objectively analyse the nature of structure revealed in Bayesian ancestry profiles using established statistical methods. ObStruct evaluates the extent of structural similarity between sampled and inferred populations, tests the significance of population differentiation, provides information on the contribution of sampled and inferred populations to the observed structure and crucially determines whether the predetermined factor of interest correlates with inferred population structure. Analyses of simulated and experimental data highlight ObStruct's ability to objectively assess the nature of structure in populations. We show the method is capable of capturing an increase in the level of structure with increasing time since divergence between simulated populations. Further, we applied the method to a highly structured dataset of 1,484 humans from seven continents and a less structured dataset of 179 Saccharomyces cerevisiae from three regions in New Zealand. Our results show that ObStruct provides an objective metric to classify the degree, drivers and significance of inferred structure, as well as providing novel insights into the relationships between sampled populations, and adds a final step to the pipeline for population structure analyses.

  20. Obésité abdominale et autres biomarqueurs de risque ...

    African Journals Online (AJOL)

    Obésité abdominale et autres biomarqueurs de risque cardiométabolique: influence du niveau socioéconomique et du mode de vie dans deux populations noires apparentées, Cotonou (Bénin) et Port-au-Prince (Haïti). Asma EL Mabchour, Hélène Delisle, Colette Vilgrain, Phillipe Larco, Roger Sodjinou ...

  1. Bioinformatics analysis identify novel OB fold protein coding genes in C. elegans.

    Directory of Open Access Journals (Sweden)

    Daryanaz Dargahi

    Full Text Available BACKGROUND: The C. elegans genome has been extensively annotated by the WormBase consortium that uses state of the art bioinformatics pipelines, functional genomics and manual curation approaches. As a result, the identification of novel genes in silico in this model organism is becoming more challenging requiring new approaches. The Oligonucleotide-oligosaccharide binding (OB fold is a highly divergent protein family, in which protein sequences, in spite of having the same fold, share very little sequence identity (5-25%. Therefore, evidence from sequence-based annotation may not be sufficient to identify all the members of this family. In C. elegans, the number of OB-fold proteins reported is remarkably low (n=46 compared to other evolutionary-related eukaryotes, such as yeast S. cerevisiae (n=344 or fruit fly D. melanogaster (n=84. Gene loss during evolution or differences in the level of annotation for this protein family, may explain these discrepancies. METHODOLOGY/PRINCIPAL FINDINGS: This study examines the possibility that novel OB-fold coding genes exist in the worm. We developed a bioinformatics approach that uses the most sensitive sequence-sequence, sequence-profile and profile-profile similarity search methods followed by 3D-structure prediction as a filtering step to eliminate false positive candidate sequences. We have predicted 18 coding genes containing the OB-fold that have remarkably partially been characterized in C. elegans. CONCLUSIONS/SIGNIFICANCE: This study raises the possibility that the annotation of highly divergent protein fold families can be improved in C. elegans. Similar strategies could be implemented for large scale analysis by the WormBase consortium when novel versions of the genome sequence of C. elegans, or other evolutionary related species are being released. This approach is of general interest to the scientific community since it can be used to annotate any genome.

  2. Diacylglycerol production induced by growth hormone in Ob1771 preadipocytes arises from phosphatidylcholine breakdown

    International Nuclear Information System (INIS)

    Catalioto, R.M.; Ailhaud, G.; Negrel, R.

    1990-01-01

    Growth Hormone has recently been shown to stimulate the formation of diacylglycerol in Ob1771 mouse preadipocyte cells without increasing inositol lipid turnover. Addition of growth hormone to Ob1771 cells prelabelled with [ 3 H]glycerol or [ 3 H]choline led to a rapid, transient and stoechiometric formation of labelled diacylglycerol and phosphocholine, respectively. In contrast, no change was observed in the level of choline and phosphatidic acid whereas the release of water-soluble metabolites in [ 3 H]ethanolamine prelabelled cells exposed to growth hormone was hardly detectable. Stimulation by growth hormone of cells prelabelled with (2-palmitoyl 9, 10 [ 3 H])phosphatidylcholine also induced the production of labelled diacyglycerol. Pertussis toxin abolished both diacylglycerol and phosphocholine formation induced by growth hormone. It is concluded that growth hormone mediates diacylglycerol production in Ob1771 cells by means of phosphatidylcholine breakdown involving a phospholipase C which is likely coupled to the growth hormone receptor via a pertussis toxin-sensitive G-protein

  3. Relative Stabilities of Conserved and Non-Conserved Structures in the OB-Fold Superfamily

    Directory of Open Access Journals (Sweden)

    Andrei T. Alexandrescu

    2009-05-01

    Full Text Available The OB-fold is a diverse structure superfamily based on a β-barrel motif that is often supplemented with additional non-conserved secondary structures. Previous deletion mutagenesis and NMR hydrogen exchange studies of three OB-fold proteins showed that the structural stabilities of sites within the conserved β-barrels were larger than sites in non-conserved segments. In this work we examined a database of 80 representative domain structures currently classified as OB-folds, to establish the basis of this effect. Residue-specific values were obtained for the number of Cα-Cα distance contacts, sequence hydrophobicities, crystallographic B-factors, and theoretical B-factors calculated from a Gaussian Network Model. All four parameters point to a larger average flexibility for the non-conserved structures compared to the conserved β-barrels. The theoretical B-factors and contact densities show the highest sensitivity.Our results suggest a model of protein structure evolution in which novel structural features develop at the periphery of conserved motifs. Core residues are more resistant to structural changes during evolution since their substitution would disrupt a larger number of interactions. Similar factors are likely to account for the differences in stability to unfolding between conserved and non-conserved structures.

  4. Improvements to the gridding of precipitation data across Europe under the E-OBS scheme

    Science.gov (United States)

    Cornes, Richard; van den Besselaar, Else; Jones, Phil; van der Schrier, Gerard; Verver, Ge

    2016-04-01

    Gridded precipitation data are a valuable resource for analyzing past variations and trends in the hydroclimate. Such data also provide a reference against which model simulations may be driven, compared and/or adjusted. The E-OBS precipitation dataset is widely used for such analyses across Europe, and is particularly valuable since it provides a spatially complete, daily field across the European domain. In this analysis, improvements to the E-OBS precipitation dataset will be presented that aim to provide a more reliable estimate of grid-box precipitation values, particularly in mountainous areas and in regions with a relative sparsity of input station data. The established three-stage E-OBS gridding scheme is retained, whereby monthly precipitation totals are gridded using a thin-plate spline; daily anomalies are gridded using indicator kriging; and the final dataset is produced by multiplying the two grids. The current analysis focuses on improving the monthly thin-plate spline, which has overall control on the final daily dataset. The results from different techniques are compared and the influence on the final daily data is assessed by comparing the data against gridded country-wide datasets produced by various National Meteorological Services

  5. An unidentified TeV source in the vicinity of Cygnus OB2

    Science.gov (United States)

    Aharonian, F.; Akhperjanian, A.; Beilicke, M.; Bernlöhr, K.; Börst, H.; Bojahr, H.; Bolz, O.; Coarasa, T.; Contreras, J.; Cortina, J.; Denninghoff, S.; Fonseca, V.; Girma, M.; Götting, N.; Heinzelmann, G.; Hermann, G.; Heusler, A.; Hofmann, W.; Horns, D.; Jung, I.; Kankanyan, R.; Kestel, M.; Kettler, J.; Kohnle, A.; Konopelko, A.; Kornmeyer, H.; Kranich, D.; Krawczynski, H.; Lampeitl, H.; Lopez, M.; Lorenz, E.; Lucarelli, F.; Magnussen, N.; Mang, O.; Meyer, H.; Milite, M.; Mirzoyan, R.; Moralejo, A.; Ona, E.; Panter, M.; Plyasheshnikov, A.; Prahl, J.; Pühlhofer, G.; Rauterberg, G.; Reyes, R.; Rhode, W.; Ripken, J.; Röhring, A.; Rowell, G. P.; Sahakian, V.; Samorski, M.; Schilling, M.; Schröder, F.; Siems, M.; Sobzynska, D.; Stamm, W.; Tluczykont, M.; Völk, H. J.; Wiedner, C. A.; Wittek, W.; Uchiyama, Y.; Takahashi, T.; HEGRA Collaboration

    2002-10-01

    Deep observation ( ~ 113 hrs) of the Cygnus region at TeV energies using the HEGRA stereoscopic system of air Čerenkov telescopes has serendipitously revealed a signal positionally inside the core of the OB association Cygnus OB2, at the edge of the 95% error circle of the EGRET source 3EG J2033+4118, and ~ 0.5o north of Cyg X-3. The source centre of gravity is RA alphaJ2000: 20h 32m 07s+/- 9.2sstat +/-2.2ssys, Dec deltaJ2000: +41o 30' 30''+/- 2.0'stat +/- 0.4'sys. The source is steady, has a post-trial significance of +4.6sigma , indication for extension with radius 5.6' at the ~ 3sigma level, and has a differential power-law flux with hard photon index of -1.9 +/-0.3stat +/-0.3sys. The integral flux above 1 TeV amounts ~ 3% that of the Crab. No counterpart for the TeV source at other wavelengths is presently identified, and its extension would disfavour an exclusive pulsar or AGN origin. If associated with Cygnus OB2, this dense concentration of young, massive stars provides an environment conducive to multi-TeV particle acceleration and likely subsequent interaction with a nearby gas cloud. Alternatively, one could envisage gamma -ray production via a jet-driven termination shock.

  6. A model for the infrared emission from an OB star cluster environment

    International Nuclear Information System (INIS)

    Leisawitz, D.

    1990-01-01

    Researchers developed an interactive radiative transfer code that predicts the infrared emission from an HII region containing diffuse ionized and atomic gas and dense molecular clouds. This model complements the investigation of the redistribution of OB star luminosity in the interstellar medium (Leisawitz and Hauser 1988, Ap. J., 332, 954). The model can be used as a diagnostic tool to probe the radiation field and matter density in an HII region, place constraints on the proximity and orientation of an illuminated molecular cloud with respect to the ionizing stars, test for the presence of small, transiently heated dust grains, and determine whether the dust-to-gas ratio is normal. Predictions of the model agree qualitatively and quantitatively with observations of blister-type HII regions ionized by well-studied OB clusters in which the distribution of dense neutral material is known. This is illustrated by a model for Infrared Astronomy Satellite (IRAS) observations of the region around NGC 7380 (S142). Researchers plan to use the model in a survey of regions of massive star formation in the outer Galaxy to study OB stars embedded to various degrees in their parental molecular clouds

  7. ObsPy – What can it do for data centers and observatories?

    Directory of Open Access Journals (Sweden)

    Joachim Wassermann

    2011-04-01

    Full Text Available Data acquisition by seismic centers relies on real-time systems, like SeisComP3, Antelope and Earthworm. However, these are complex systems that are designed for fast and precisely defined standard real-time analyses. Therefore, it is not a simple task to access or modify internal routines, and to integrate them into custom-processing workflows or to perform in-depth data analyses. Often a library is necessary that provides convenient access to data and allows easy control over all of the operations that are to be performed on the data. ObsPy is such a library, which is designed to access and process seismological waveform data and metadata. We use short and simple examples here to demonstrate how effective it is to use Python for seismological data analysis. Then, we illustrate the general capabilities of ObsPy, and highlight some of its specific aspects that are relevant for seismological data centers and observatories, through presentation of real-world examples. Finally, we demonstrate how the ObsPy library can be used to develop custom graphical user interface applications.

  8. Diacylglycerol production induced by growth hormone in Ob1771 preadipocytes arises from phosphatidylcholine breakdown

    Energy Technology Data Exchange (ETDEWEB)

    Catalioto, R.M.; Ailhaud, G.; Negrel, R. (Universite de Nice-Sophia Antipolis (France))

    1990-12-31

    Growth Hormone has recently been shown to stimulate the formation of diacylglycerol in Ob1771 mouse preadipocyte cells without increasing inositol lipid turnover. Addition of growth hormone to Ob1771 cells prelabelled with ({sup 3}H)glycerol or ({sup 3}H)choline led to a rapid, transient and stoechiometric formation of labelled diacylglycerol and phosphocholine, respectively. In contrast, no change was observed in the level of choline and phosphatidic acid whereas the release of water-soluble metabolites in ({sup 3}H)ethanolamine prelabelled cells exposed to growth hormone was hardly detectable. Stimulation by growth hormone of cells prelabelled with (2-palmitoyl 9, 10 ({sup 3}H))phosphatidylcholine also induced the production of labelled diacyglycerol. Pertussis toxin abolished both diacylglycerol and phosphocholine formation induced by growth hormone. It is concluded that growth hormone mediates diacylglycerol production in Ob1771 cells by means of phosphatidylcholine breakdown involving a phospholipase C which is likely coupled to the growth hormone receptor via a pertussis toxin-sensitive G-protein.

  9. A M2FS Spectroscopic Study of Low-mass Young Stars in Orion OB1

    Science.gov (United States)

    Kaleida, Catherine C.; Briceno, Cesar; Calvet, Nuria; Mateo, Mario L.; Hernandez, Jesus

    2015-01-01

    Surveys of pre-main sequence stars in the ~4-10 Myr range provide a window into the decline of the accretion phase of stars and the formation of planets. Nearby star clusters and stellar associations allow for the study of these young stellar populations all the way down to the lowest mass members. One of the best examples of nearby 4-10 Myr old stellar populations is the Orion OB1 association. The CIDA Variability Survey of Orion OB1 (CVSO - Briceño et al. 2001) has used the variability properties of low-mass pre-main-sequence (PMS) stars to identify hundreds of K and M-type stellar members of the Orion OB1 association, a number of them displaying IR-excess emission and thought to be representative of more evolved disk-bearing young stars. Characterizing these young, low-mass objects using spectroscopy is integral to understanding the accretion phase in young stars. We present preliminary results of a spectroscopic survey of candidate and confirmed Orion OB1 low-mass members taken during November 2014 and February 2014 using the Michigan/Magellan Fiber Spectrograph (M2FS), a PI instrument on the Magellan Clay Telescope (PI: M. Matteo). Target fields located in the off-cloud regions of Orion were identified in the CVSO, and observed using the low and high-resolution modes of M2FS. Both low and high-resolution spectra are needed in order to confirm membership and derive masses, ages, kinematics and accretion properties. Initial analysis of these spectra reveal many new K and M-type members of the Orion OB1 association in these low extinction, off-cloud areas. These are the more evolved siblings of the youngest stars still embedded in the molecular clouds, like those in the Orion Nebula Cluster. With membership and spectroscopic indicators of accretion we are building the most comprehensive stellar census of this association, enabling us to derive a robust estimate of the fraction of young stars still accreting at a various ages, a key constraint for the end of

  10. VizieR Online Data Catalog: Properties of OB associations in IC 1613 (Garcia+, 2010)

    Science.gov (United States)

    Garcia, M.; Herrero, A.; Castro, N.; Corral, L.; Rosenberg, A.

    2014-06-01

    To understand the structure and evolution of massive stars, systematic surveys of the Local Group galaxies have been undertaken, to find these objects in environments of different chemical abundances. We focus on the metal-poor irregular galaxy IC 1613 to analyze the stellar and wind structure of its low-metallicity massive stars. We ultimately aim to study the metallicity-dependent driving mechanism of the winds of blue massive stars and use metal-poor massive stars of the Local Volume as a proxy for the stars in the early Universe. In a previous paper we produced a list of OB associations in IC 1613. Their properties are not only a powerful aid towards finding the most interesting candidate massive stars, but also reveal the structure and recent star formation history of the galaxy. We characterize these OB associations and study their connection with the galactic global properties. The reddening-free Q parameter is a powerful tool in the photometric analysis of young populations of massive stars, since it exhibits a smaller degree of degeneracy with OB spectral types than the B-V color. The color-magnitude diagram (Q vs. V) of the OB associations in IC 1613 is studied to determine their age and mass, and confirm the population of young massive stars. We identified more than 10 stars with M>=50M⊙. Spectral classification available for some of them confirm their massive nature, yet we find the common discrepancy with the spectroscopically derived masses. There is a general increasing trend of the mass of the most massive member with the number of members of each association, but not with the stellar density. The average diameter of the associations of this catalog is 40pc, half the historically considered typical size of OB associations. Size increases with the association population. The distribution of the groups strongly correlates with that of neutral and ionized hydrogen. We find the largest dispersion of association ages in the bubble region of the galaxy

  11. IPV Screening and Readiness to Respond to IPV in Ob-Gyn Settings: A Patient-Physician Study

    Directory of Open Access Journals (Sweden)

    Katherine M. Jones

    2018-01-01

    Full Text Available Purpose. Intimate partner violence (IPV is a serious, preventable public health concern that largely affects women of reproductive age. Obstetrician-gynecologists (ob-gyns have a unique opportunity to identify and support women experiencing IPV to improve women’s health. Considering recent efforts to increase IPV awareness and intervention, the present study aimed to provide a current evaluation of nationally representative samples to assess ob-gyn readiness to respond to IPV as well as patient IPV-related experiences. Methods. 400 ob-gyns were randomly selected from American College of Obstetricians and Gynecologists’ (ACOG Collaborative Ambulatory Research Network. Each physician was mailed one physician survey and 25 patient surveys. Results. IPV training/education and IPV screening practices were associated with most measures of ob-gyn readiness to respond to IPV. Among respondents, 36.8% endorsed screening all patients at annual exams; however, 36.8% felt they did not have sufficient training to assist individuals in addressing IPV. Workplace encouragement of IPV response was associated with training, screening, detection, preparation/knowledge, response practices, and resources. Thirty-one percent of patients indicated their ob-gyn had asked about possible IPV experiences during their medical visit. Conclusion. Findings highlight specific gaps in ob-gyns’ IPV knowledge and response practices to be further addressed by IPV training.

  12. Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice (ob/ob)

    Science.gov (United States)

    Mizuno, Márcia Sanae; Crisma, Amanda Rabello; Borelli, Primavera; Schäfer, Bárbara Tavares; Silveira, Mariana Póvoa; Castelucci, Patricia

    2014-01-01

    AIM: To investigate the colocalization, density and profile of neuronal areas of enteric neurons in the ileum of male obese mice. METHODS: The small intestinal samples of male mice in an obese group (OG) (C57BL/6J ob/ob) and a control group (CG) (+/+) were used. The tissues were analyzed using a double immunostaining technique for immunoreactivity (ir) of the P2X2 receptor, nitric oxide synthase (NOS), choline acetyl transferase (ChAT) and calretinin (Calr). Also, we investigated the density and profile of neuronal areas of the NOS-, ChAT- and Calr-ir neurons in the myenteric plexus. Myenteric neurons were labeled using an NADH-diaphorase histochemical staining method. RESULTS: The analysis demonstrated that the P2X2 receptor was expressed in the cytoplasm and in the nuclear and cytoplasmic membranes only in the CG. Neuronal density values (neuron/cm2) decreased 31% (CG: 6579 ± 837; OG: 4556 ± 407) and 16.5% (CG: 7796 ± 528; OG: 6513 ± 610) in the NOS-ir and calretinin-ir neurons in the OG, respectively (P < 0.05). Density of ChAT-ir (CG: 6200 ± 310; OG: 8125 ± 749) neurons significantly increased 31% in the OG (P < 0.05). Neuron size studies demonstrated that NOS, ChAT, and Calr-ir neurons did not differ significantly between the CG and OG groups. The examination of NADH-diaphorase-positive myenteric neurons revealed an overall similarity between the OG and CG. CONCLUSION: Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir, ChAT-ir and CalR-ir myenteric neurons. PMID:25320527

  13. MUG-OBS - Multiparameter Geophysical Ocean Bottom System : a new instrumental approach to monitor earthquakes.

    Science.gov (United States)

    hello, yann; Charvis, Philippe; Yegikyan, Manuk; verfaillie, Romain; Rivet, Diane

    2016-04-01

    Real time monitoring of seismic activity is a major issue for early warning of earthquakes and tsunamis. It can be done using regional scale wired nodes, such as Neptune in Canada and in the U.S, or DONET in Japan. Another approach to monitor seismic activity at sea is to deploying repeatedly OBS array like during the amphibious Cascadia Initiative (four time 1-year deployments), the Japanese Pacific Array (broadband OBSs "ocean-bottom broadband dispersion survey" with 2-years autonomy), the Obsismer program in the French Lesser Antilles (eight time 6-months deployments) and the Osisec program in Ecuador (four time 6-months deployments). These autonomous OBSs are self-recovered or recovered using an ROV. These systems are costly including ship time, and require to recover the OBS before to start working on data. Among the most recent alternative we developed a 3/4 years autonomy ocean bottom system with 9 channels (?) allowing the acquisition of different seismic or environmental parameters. MUG-OBS is a free falling instrument rated down to 6000 m. The installation of the sensor is monitored by acoustic commands from the surface and a health bulletin with data checking is recovered by acoustic during the installation. The major innovation is that it is possible to recover the data any time on demand (regularly every 6-months or after a crisis) using one of the 6 data-shuttles released from the surface by acoustic command using a one day fast cruise boat of opportunity. Since sensors stayed at the same location for 3 years, it is a perfect tool to monitor large seismic events, background seismic activity and aftershock distribution. Clock, drift measurement and GPS localization is automatic when the shuttle reaches the surface. For remote areas, shuttles released automatically and a seismic events bulletin is transmitted. Selected data can be recovered by two-way Iridium satellite communication. After a period of 3 years the main station is self-recovered by

  14. Not all stars form in clusters - measuring the kinematics of OB associations with Gaia

    Science.gov (United States)

    Ward, Jacob L.; Kruijssen, J. M. Diederik

    2018-04-01

    It is often stated that star clusters are the fundamental units of star formation and that most (if not all) stars form in dense stellar clusters. In this monolithic formation scenario, low-density OB associations are formed from the expansion of gravitationally bound clusters following gas expulsion due to stellar feedback. N-body simulations of this process show that OB associations formed this way retain signs of expansion and elevated radial anisotropy over tens of Myr. However, recent theoretical and observational studies suggest that star formation is a hierarchical process, following the fractal nature of natal molecular clouds and allowing the formation of large-scale associations in situ. We distinguish between these two scenarios by characterizing the kinematics of OB associations using the Tycho-Gaia Astrometric Solution catalogue. To this end, we quantify four key kinematic diagnostics: the number ratio of stars with positive radial velocities to those with negative radial velocities, the median radial velocity, the median radial velocity normalized by the tangential velocity, and the radial anisotropy parameter. Each quantity presents a useful diagnostic of whether the association was more compact in the past. We compare these diagnostics to models representing random motion and the expanding products of monolithic cluster formation. None of these diagnostics show evidence of expansion, either from a single cluster or multiple clusters, and the observed kinematics are better represented by a random velocity distribution. This result favours the hierarchical star formation model in which a minority of stars forms in bound clusters and large-scale, hierarchically structured associations are formed in situ.

  15. WNIN/GR-Ob - an insulin-resistant obese rat model from inbred WNIN strain.

    Science.gov (United States)

    Harishankar, N; Vajreswari, A; Giridharan, N V

    2011-09-01

    WNIN/GR-Ob is a mutant obese rat strain with impaired glucose tolerance (IGT) developed at the National Institute of Nutrition (NIN), Hyderabad, India, from the existing 80 year old Wistar rat (WNIN) stock colony. The data presented here pertain to its obese nature along with IGT trait as evidenced by physical, physiological and biochemical parameters. The study also explains its existence, in three phenotypes: homozygous lean (+/+), heterozygous carrier (+/-) and homozygous obese (-/-). Thirty animals (15 males and 15 females) from each phenotype (+/+, +/-, -/-) and 24 lean and obese (6 males and 6 females) rats were taken for growth and food intake studies respectively. Twelve adult rats from each phenotype were taken for body composition measurement by total body electrical conductivity (TOBEC); 12 rats of both genders from each phenotype at different ages were taken for clinical chemistry parameters. Physiological indices of insulin resistance were calculated according to the homeostasis model assessment for insulin resistance (HOMA-IR) and also by studying U¹⁴C 2-deoxy glucose uptake (2DG). WNINGR-Ob mutants had high growth, hyperphagia, polydipsia, polyurea, glycosuria, and significantly lower lean body mass, higher fat mass as compared with carrier and lean rats. These mutants, at 50 days of age displayed abnormal response to glucose load (IGT), hyperinsulinaemia, hypertriglyceridaemia, hypercholesterolaemia and hyperleptinaemia. Basal and insulin-stimulated glucose uptakes by diaphragm were significantly decreased in obese rats as compared with lean rats. Obese rats of the designated WNIN/GR-Ob strain showed obesity with IGT, as adjudged by physical, physiological and biochemical indices. These indices varied among the three phenotypes, being lowest in lean, highest in obese and intermediate in carrier phenotypes thereby suggesting that obesity is inherited as autosomal incomplete dominant trait in this strain. This mutant obese rat model is easy to

  16. Development of the TeamOBS-PPH - targeting clinical performance in postpartum hemorrhage.

    Science.gov (United States)

    Brogaard, Lise; Hvidman, Lone; Hinshaw, Kim; Kierkegaard, Ole; Manser, Tanja; Musaeus, Peter; Arafeh, Julie; Daniels, Kay I; Judy, Amy E; Uldbjerg, Niels

    2018-06-01

    This study aimed to develop a valid and reliable TeamOBS-PPH tool for assessing clinical performance in the management of postpartum hemorrhage (PPH). The tool was evaluated using video-recordings of teams managing PPH in both real-life and simulated settings. A Delphi panel consisting of 12 obstetricians from the UK, Norway, Sweden, Iceland, and Denmark achieved consensus on (i) the elements to include in the assessment tool, (ii) the weighting of each element, and (iii) the final tool. The validity and reliability were evaluated according to Cook and Beckman. (Level 1) Four raters scored four video-recordings of in situ simulations of PPH. (Level 2) Two raters scored 85 video-recordings of real-life teams managing patients with PPH ≥1000 mL in two Danish hospitals. (Level 3) Two raters scored 15 video-recordings of in situ simulations of PPH from a US hospital. The tool was designed with scores from 0 to 100. (Level 1) Teams of novices had a median score of 54 (95% CI 48-60), whereas experienced teams had a median score of 75 (95% CI 71-79; p < 0.001). (Level 2) The intra-rater [intra-class correlation (ICC) = 0.96] and inter-rater (ICC = 0.83) agreements for real-life PPH were strong. The tool was applicable in all cases: atony, retained placenta, and lacerations. (Level 3) The tool was easily adapted to in situ simulation settings in the USA (ICC = 0.86). The TeamOBS-PPH tool appears to be valid and reliable for assessing clinical performance in real-life and simulated settings. The tool will be shared as the free TeamOBS App. © 2018 Nordic Federation of Societies of Obstetrics and Gynecology.

  17. OB ASSOCIATIONS AT THE UPPER END OF THE MILKY WAY LUMINOSITY FUNCTION

    Energy Technology Data Exchange (ETDEWEB)

    Rahman, Mubdi; Matzner, Christopher D.; Moon, Dae-Sik, E-mail: mubdi@pha.jhu.edu [Department of Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, ON M5S 3H8 (Canada)

    2013-04-01

    The Milky Way's most luminous, young, and massive (M {approx}> 10{sup 4} M{sub Sun }) star clusters and OB associations have largely evaded detection despite knowledge of their surrounding H II regions. We search for these clusters and associations within the 40 star-forming complexes from Rahman and Murray in the 13 most luminous Wilkinson Microwave Anisotropy Probe (WMAP) free-free emission sources of the Galaxy. Selecting for objects with the dust-reddened colors of OB stars, we identify new candidate associations using the Two Micron All Sky Survey point-source catalog. In 40 star-forming complexes searched, 22 contain cluster/association candidates with sizes and masses in the range of 3'-26' and 10{sup 2.3}-10{sup 5} M{sub Sun }. Of the 22 candidates, at least seven have estimated masses {approx}> 10{sup 4} M{sub Sun }, doubling the number of such massive clusters known in the Galaxy. Only one of the searched WMAP sources remains without a candidate. Applying our method to a statistically similar set of test locations, we estimate that 3.0 {+-} 0.6 of our 22 candidate associations are unrelated to the star-forming complexes. In addition, the apparent extinctions of our candidate associations correlate well with the predictions from a Galactic model. These facts, along with the clear detection of a known OB association and the previous spectral verification of one cluster found by this method, validate our method. In eight of the most luminous WMAP sources, the candidate associations can account for the observed free-free flux. With our new compilation, the Galactic census of young, massive stellar associations may now be about half complete.

  18. A Multi-Fiber Spectroscopic Search for Low-mass Young Stars in Orion OB1

    Science.gov (United States)

    Loerincs, Jacqueline; Briceno, Cesar; Calvet, Nuria; Mateo, Mario L.; Hernandez, Jesus

    2017-01-01

    We present here results of a low resolution spectroscopic followup of candidate low-mass pre-main sequence stars in the Orion OB1 association. Our targets were selected from the CIDA Variability Survey of Orion (CVSO), and we used the Michigan/Magellan Fiber Spectrograph (M2FS) on the Magellan Clay 6.5m telescope to obtain spectra of 500 candidate T Tauri stars distributed in seven 0.5 deg diameter fields, adding to a total area of ~5.5 deg2. We identify young stars by looking at the distinctive Hα 6563 Å emission and Lithium Li I 6707 Å absorption features characteristic of young low mass pre-main sequence stars. Furthermore, by measuring the strength of their Hα emission lines, confirmed T Tauri stars can be classified as either Classical T Tauris (CTTS) or Weak-line T Tauris (WTTS), which give indication of whether the star is actively accreting material from a gas and dust disk surrounding the star, which may be the precursor of a planetary system. We confirm a total of 90 T Tauri stars, of which 50% are newly identified young members of Orion; out of the 49 new detections,15 are accreting CTTS, and of these all but one are found in the OB1b sub-region. This result is in line with our previous findings that this region is much younger than the more extended Orion OB1a sub-association. The M2FS results add to our growing census of young stars in Orion, that is allowing us to characterize in a systematic and consistent way the distribution of stellar ages across the entire complex, in order to building a complete picture of star formation in this, one of nearest most active sites of star birth.

  19. Nature vs. Nurture: The influence of OB star environments on proto-planetary disk evolution

    Science.gov (United States)

    Bouwman, Jeroen

    2006-09-01

    We propose a combined IRAC/IRS study of a large, well-defined and unbiased X-ray selected sample of pre-main-sequence stars in three OB associations: Pismis 24 in NGC 6357, NGC 2244 in the Rosette Nebula, and IC 1795 in the W3 complex. The samples are based on recent Chandra X-ray Observatory studies which reliably identify hundreds of cluster members and were carefully chosen to avoid high infrared nebular background. A new Chandra exposure of IC 1795 is requested, and an optical followup to characterise the host stars is planned.

  20. Polimorfismos del gen ob en bovinos de raza holstein en la Comarca Lagunera, México

    OpenAIRE

    Sarai S. Mendoza-Retana; Miguel A. Gallegos-Robles; Uriel González-Salas; José L. García-Hernández; Manuel Fortis-Hernández; Cirilo Vázquez-Vázquez; Héctor I. Trejo-Escareño

    2017-01-01

    La Comarca Lagunera es la cuenca lechera más importante de México. En la actualidad se están utilizando diversas técnicas que permiten evaluar genéticamente el animal a una edad temprana, permitiendo seleccionar futuros reproductores con características deseables. Entre los genes relacionados con la producción de leche, se encuentran el gen Ob también llamado gen Leptina el cual actúa sobre el sistema nervioso central y tejidos periféricos jugando un papel muy importante ...

  1. Direct Imaging and Spectroscopy of a Young Extrasolar Kuiper Belt in the Nearest OB Association

    OpenAIRE

    Currie, Thayne; Lisse, Carey M.; Kuchner, Marc J.; Madhusudhan, Nikku; Kenyon, Scott J.; Thalmann, Christian; Carson, Joseph; Debes, John H.

    2015-01-01

    We describe the discovery of a bright, young Kuiper belt-like debris disk around HD 115600, a $\\sim$ 1.4--1.5 M$_\\mathrm{\\odot}$, $\\sim$ 15 Myr old member of the Sco-Cen OB Association. Our H-band coronagraphy/integral field spectroscopy from the \\textit{Gemini Planet Imager} shows the ring has a (luminosity scaled) semi major axis of ($\\sim$ 22 AU) $\\sim$ 48 AU, similar to the current Kuiper belt. The disk appears to have neutral scattering dust, is eccentric (e $\\sim$ 0.1--0.2), and could b...

  2. Eukaryotic RNA polymerase subunit RPB8 is a new relative of the OB family.

    Science.gov (United States)

    Krapp, S; Kelly, G; Reischl, J; Weinzierl, R O; Matthews, S

    1998-02-01

    RNA polymerase II subunit RPB8 is an essential subunit that is highly conserved throughout eukaryotic evolution and is present in all three types of nuclear RNA polymerases. We report the first high resolution structural insight into eukaryotic RNA polymerase architecture with the solution structure of RPB8 from Saccharomyces cerevisiae. It consists of an eight stranded, antiparallel beta-barrel, four short helical regions and a large, unstructured omega-loop. The strands are connected in classic Greek-key fashion. The overall topology is unusual and contains a striking C2 rotational symmetry. Furthermore, it is most likely a novel associate of the oligonucleotide/oligosaccharide (OB) binding protein class.

  3. BOREAS TF-8 NSA-OJP and SSA-OBS Ceilometer Data

    Science.gov (United States)

    Moore, Kathleen E.; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Fitzjarrald, David R.

    2000-01-01

    The BOREAS TF-8 team used ceilometers to collect data on the fraction of the sky covered with clouds and the cloud height. Included with these data is the surface-based lifting condensation level, derived from temperature and humidity values acquired at the flux tower at the NSA-OJP site. Ceilo-meter data were collected at the NSA-OJP site in 1994 and at the NSA-OJP and SSA-OBS sites in 1996. The data are available in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884).

  4. Adipose cell differentiation: evidence for a two-step process in the polyamine-dependent Ob1754 clonal line.

    Science.gov (United States)

    Amri, E Z; Dani, C; Doglio, A; Etienne, J; Grimaldi, P; Ailhaud, G

    1986-01-01

    A subclone of preadipocyte Ob17 cells has been isolated (Ob1754 clonal line). Confluent Ob1754 cells treated with an inhibitor of spermidine and spermine synthesis, methylglyoxal bis(guanylhydrazone), were totally dependent upon putrescine addition for the expression of glycerol-3-phosphate dehydrogenase which behaved as a late marker of adipose conversion. Under these conditions, the early expression of lipoprotein lipase during growth arrest remained unchanged. Studies at the mRNA level showed that the expression of unidentified pOb24 and pGH3 mRNAs, which was parallel to that of lipoprotein lipase, is independent of polyamine addition whereas the late emergence of glycerol-3-phosphate dehydrogenase mRNA was putrescine-dependent and co-ordinated with the expression of pAL422 mRNA encoding for a myelin-P2 homologue [Bernlohr, Angus, Lane, Bolanowski & Kelly (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 5468-5472]. The appearance of lipoprotein lipase preceded DNA synthesis and post-confluent mitoses which were both putrescine-dependent and which took place before the appearance of glycerol-3-phosphate dehydrogenase. Thus the adipose conversion of Ob1754 cells involves the expression of at least two separate sets of markers which are differently regulated. Images Fig. 3. Fig. 6. PMID:3800927

  5. EVIDENCE FOR DELAYED MASSIVE STAR FORMATION IN THE M17 PROTO-OB ASSOCIATION

    International Nuclear Information System (INIS)

    Povich, Matthew S.; Whitney, Barbara A.

    2010-01-01

    Through analysis of archival images and photometry from the Spitzer GLIMPSE and MIPSGAL surveys combined with Two Micron All Sky Survey and MSX data, we have identified 488 candidate young stellar objects (YSOs) in the giant molecular cloud M17 SWex, which extends ∼50 pc southwest from the prominent Galactic H II region M17. Our sample includes >200 YSOs with masses >3 M sun that will become B-type stars on the main sequence. Extrapolating over the stellar initial mass function (IMF), we find that M17 SWex contains >1.3 x 10 4 young stars, representing a proto-OB association. The YSO mass function is significantly steeper than the Salpeter IMF, and early O stars are conspicuously absent from M17 SWex. Assuming M17 SWex will form an OB association with a Salpeter IMF, these results reveal the combined effects of (1) more rapid circumstellar disk evolution in more massive YSOs and (2) delayed onset of massive star formation.

  6. La binaria LSS 3074 y su entorno: ?`una nueva asociación OB?

    Science.gov (United States)

    Niemela, V.; Morrell, N.; Corti, M.

    En este trabajo presentamos un nuevo análisis orbital de LSS~3074, junto con tipos espectrales y velocidades radiales de estrellas que podrían constituir con ella una nueva asociación OB. La estrella O4f LSS3074 fue descubierta como binaria espectroscópica de corto período y líneas dobles por Morrell & Niemela (1990, ASP Conf. Ser. 7, 57). Posteriormente, Haefner et~al.(1994, IBVS 3969) encontraron variaciones fotométricas, estimando una inclinación orbital entre 50o y 55o. Teniendo en cuenta la importancia de obtener valores empíricos para las masas de estrellas O tempranas, y considerando la gran dispersión existente entre los valores observados y su discrepancia con los predichos por los modelos teóricos, hemos obtenido nuevas observaciones espectroscópicas de este sistema, con el propósito de mejorar los elementos orbitales derivados en la solución preliminar. Además, como las estrellas O tempranas suelen formar parte de cúmulos y asociaciones OB, hemos llevado a cabo una investigación espectroscópica de varias estrellas tempranas que podrían estar físicamente relacionadas con LSS~3074.

  7. Hard X-ray Flux from Low-Mass Stars in the Cygnus OB2 Association

    Science.gov (United States)

    Caramazza, M.; Drake, J. J.; Micela, G.; Flaccomio, E.

    2009-05-01

    We investigate the X-ray emission in the 20-40 keV band expected from the flaring low-mass stellar population in Cygnus OB2 assuming that the observed soft X-ray emission is due to a superposition of flares and that the ratio of hard X-ray to soft X-ray emission is described by a scaling found for solar flares by Isola and co-workers. We estimate a low-mass stellar hard X-ray flux in the 20-40 keV band in the range ~7×1031-7×1033 erg/s and speculate the limit of this values. Hard X-ray emission could lie at a level not much below the current observed flux upper limits for Cygnus OB2. Simbol-X, with its broad energy band (10-100 keV) and its sensitivity should be able to detect this emission and would provide insights into the hard X-ray production of flares on pre-main sequence stars.

  8. Into the Darkness: Interstellar Extinction Near the Cepheus OB3 Molecular Cloud

    Science.gov (United States)

    Fitzpatrick, Edward L.; Jacklin, S.; Massa, D.

    2014-01-01

    We present the results of a followup investigation to a study performed by Massa and Savage (1984, ApJ, 279, 310) of the properties of UV interstellar extinction in the region of the Cepheus OB3 molecular cloud. That study was performed using UV photometry and spectro-photometry from the ANS and IUE satellites. We have extended this study into the IR, utilizing the uniform database of IR photometry available from the 2MASS project. This is a part of a larger program whose goal is to study the properties of extinction in localized regions, where we hope to find clues to dust grain growth and destruction processes through spatial correlations of extinction with distinct environmental properties. Similarly to Massa and Savage’s UV results, we find that the IR extinction properties on the Cepheus OB3 region vary systematically with the apparent proximity of the target stars to the molecular cloud. We also find that the UV extinction and the IR extinction are crudely correlated. The methodology leading to these results and their implications are discussed.

  9. OB Stars and Cepheids From the Gaia TGAS Catalogue: Test of their Distances and Proper Motions

    Directory of Open Access Journals (Sweden)

    Bobylev Vadim V.

    2017-12-01

    Full Text Available We consider young distant stars from the Gaia TGAS catalog. These are 250 classical Cepheids and 244 OB stars located at distances up to 4 kpc from the Sun. These stars are used to determine the Galactic rotation parameters using both trigonometric parallaxes and proper motions of the TGAS stars. In this case the considered stars have relative parallax errors less than 200%. Following the well-known statistical approach, we assume that the kinematic parameters found from the line-of-sight velocities Vr are less dependent on errors of distances than the found from the velocity components Vl. From values of the first derivative of the Galactic rotation angular velocity ′0, found from the analysis of velocities Vr and Vl separately, the scale factor of distances is determined.We found that from the sample of Cepheids the scale of distances of the TGAS should be reduced by 3%, and from the sample of OB stars, on the contrary, the scale should be increased by 9%.

  10. A CANDIDATE FOR THE MOST LUMINOUS OB ASSOCIATION IN THE GALAXY

    International Nuclear Information System (INIS)

    Rahman, Mubdi; Matzner, Christopher; Moon, Dae-Sik

    2011-01-01

    The Milky Way harbors giant H II regions, which may be powered by star complexes more luminous than any known Galactic OB association. Being across the disk of the Galaxy, however, these brightest associations are severely extinguished and confused. We present a search for one such association toward the most luminous H II region in the recent catalog by Murray and Rahman, which, at ∼9.7 kpc, has a recombination rate of ∼7 x 10 51 s -1 . Prior searches have identified only small-scale clustering around the rim of this shell-like region, but the primary association has not previously been identified. We apply a near-infrared color selection and find an overdensity of point sources toward its southern central part. The colors and magnitudes of these excess sources are consistent with O- and early B-type stars at extinctions 0.96 K < 1.2, and they are sufficiently numerous (406 ± 102 after subtraction of field sources) to ionize the surrounding H II region, making this a candidate for the most luminous OB association in the Galaxy. We reject an alternate theory, in which the apparent excess is caused by localized extinction, as inconsistent with source demographics.

  11. Analysis of interstellar extinction towards the hypergiant Cyg OB2 No. 12

    Science.gov (United States)

    Maryeva, O. V.; Chentsov, E. L.; Goranskij, V. P.; Karpov, S. V.

    The Cyg OB2 stellar association hosts an entire zoo of unique objects, and among them -- an enigmatic star Cyg OB2 No. 12 (Schulte 12, MT 304). MT 304 is enigmatic not only due to its highest luminosity (according to various estimates, it is one of the brightest stars in the Galaxy), but also because its reddening is anomalously large, greater than the mean reddening in the association. To explain the nature of anomalous reddening (AV≃ 10 mag) of MT 304, we carried out spectrophotometric observations of 25 stars located in its vicinity. We mapped interstellar extinction within the 2.5 arcmin radius and found it to increase towards MT 304. According to our results, the two most reddened stars in the association after MT 304 are J203240.35+411420.1 and J203239.90+411436.2, both located about 15 arcsec from it. Interstellar extinction AV towards these stars is about 9 mag. Our results favor the hypothesis of the circumstellar nature of reddening excess. In the second part of the paper we present the results of our modeling of MT 282 (B1 IV) and MT 343 (B1 V), which belong to the older population of the association and have ages greater than 10 Myr.

  12. The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold

    International Nuclear Information System (INIS)

    Das, Debanu; Kozbial, Piotr; Han, Gye Won; Carlton, Dennis; Jaroszewski, Lukasz; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L.; Bakolitsa, Constantina; Chen, Connie; Chiu, Hsiu-Ju; Chiu, Michelle; Clayton, Thomas; Deller, Marc C.; Duan, Lian; Ellrott, Kyle; Elsliger, Marc-André; Ernst, Dustin; Farr, Carol L.; Feuerhelm, Julie; Grzechnik, Anna; Grant, Joanna C.; Jin, Kevin K.; Johnson, Hope A.; Klock, Heath E.; Knuth, Mark W.; Krishna, S. Sri; Kumar, Abhinav; Marciano, David; McMullan, Daniel; Miller, Mitchell D.; Morse, Andrew T.; Nigoghossian, Edward; Nopakun, Amanda; Okach, Linda; Oommachen, Silvya; Paulsen, Jessica; Puckett, Christina; Reyes, Ron; Rife, Christopher L.; Sefcovic, Natasha; Tien, Henry J.; Trame, Christine B.; Bedem, Henry van den; Weekes, Dana; Wooten, Tiffany; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A.

    2009-01-01

    KPN03535 is a protein unique to K. pneumoniae. The crystal structure reveals that KPN03535 represents a novel variant of the OB-fold and is likely to be a DNA-binding lipoprotein. KPN03535 (gi|152972051) is a putative lipoprotein of unknown function that is secreted by Klebsiella pneumoniae MGH 78578. The crystal structure reveals that despite a lack of any detectable sequence similarity to known structures, it is a novel variant of the OB-fold and structurally similar to the bacterial Cpx-pathway protein NlpE, single-stranded DNA-binding (SSB) proteins and toxins. K. pneumoniae MGH 78578 forms part of the normal human skin, mouth and gut flora and is an opportunistic pathogen that is linked to about 8% of all hospital-acquired infections in the USA. This structure provides the foundation for further investigations into this divergent member of the OB-fold family

  13. Far-infrared and CO observations of Cep F: Implications for star formation in Cepheus OB3

    International Nuclear Information System (INIS)

    Sargent, A.I.; van Duinen, R.J.; Nordh, H.L.; Fridlund, C.V.M.; Aalders, J.W.G.; Beintema, D.

    1983-01-01

    Observations at 80-μm and 130-μm have revealed a source of far-infrared emission in the Cep F portion of the Cepheus OB3 molecular cloud. Molecular line measurements of this region, at the CO J = 1-0 line frequency, have led to the discovery of two CO maxima. One of these coincides with the new far-infrared source. The other is at least as intense as Cep B, until now considered to be the hottest part of the cloud. There is some evidence to suggest that a second far-infrared source is associated with this hotspot. If the far-infrared emission results from the presence of embedded protostars, their location, relative to the OB association stars and to the other active region, Cep A, requires a reexamination of how stars form in the Cepheus OB3 association

  14. Toward Complete Statistics of Massive Binary Stars: Penultimate Results from the Cygnus OB2 Radial Velocity Survey

    OpenAIRE

    Kobulnicky, Henry A.; Kiminki, Daniel C.; Lundquist, Michael J.; Burke, Jamison; Chapman, James; Keller, Erica; Lester, Kathryn; Rolen, Emily K.; Topel, Eric; Bhattacharjee, Anirban; Smullen, Rachel A.; Alvarez, Carlos A. Vargas; Runnoe, Jessie C.; Dale, Daniel A.; Brotherton, Michael M.

    2014-01-01

    We analyze orbital solutions for 48 massive multiple-star systems in the Cygnus OB2 Association, 23 of which are newly presented here, to find that the observed distribution of orbital periods is approximately uniform in log P for P 45 d, even after correction for completeness, indicating either a lower binary fraction or a shift toward low-mass companions. A high degree of similarity (91% likelihood) between the Cyg OB2 period distribution and that of other surveys suggests that the binary p...

  15. Asteroseismology of OB stars with hundreds of single snapshot spectra (and a few time-series of selected targets)

    Science.gov (United States)

    Simón-Díaz, S.

    2015-01-01

    Imagine we could do asteroseismology of large samples of OB-type stars by using just one spectrum per target. That would be great! But this is probably a crazy and stupid idea. Or maybe not. Maybe we have the possibility to open a new window to investigate stellar oscillations in massive stars that has been in front of us for many years, but has not attracted very much our attention: the characterization and understanding of the so-called macroturbulent broadening in OB-type stars.

  16. Optimal Inversion Parameters for Full Waveform Inversion using OBS Data Set

    Science.gov (United States)

    Kim, S.; Chung, W.; Shin, S.; Kim, D.; Lee, D.

    2017-12-01

    In recent years, full Waveform Inversion (FWI) has been the most researched technique in seismic data processing. It uses the residuals between observed and modeled data as an objective function; thereafter, the final subsurface velocity model is generated through a series of iterations meant to minimize the residuals.Research on FWI has expanded from acoustic media to elastic media. In acoustic media, the subsurface property is defined by P-velocity; however, in elastic media, properties are defined by multiple parameters, such as P-velocity, S-velocity, and density. Further, the elastic media can also be defined by Lamé constants, density or impedance PI, SI; consequently, research is being carried out to ascertain the optimal parameters.From results of advanced exploration equipment and Ocean Bottom Seismic (OBS) survey, it is now possible to obtain multi-component seismic data. However, to perform FWI on these data and generate an accurate subsurface model, it is important to determine optimal inversion parameters among (Vp, Vs, ρ), (λ, μ, ρ), and (PI, SI) in elastic media. In this study, staggered grid finite difference method was applied to simulate OBS survey. As in inversion, l2-norm was set as objective function. Further, the accurate computation of gradient direction was performed using the back-propagation technique and its scaling was done using the Pseudo-hessian matrix.In acoustic media, only Vp is used as the inversion parameter. In contrast, various sets of parameters, such as (Vp, Vs, ρ) and (λ, μ, ρ) can be used to define inversion in elastic media. Therefore, it is important to ascertain the parameter that gives the most accurate result for inversion with OBS data set.In this study, we generated Vp and Vs subsurface models by using (λ, μ, ρ) and (Vp, Vs, ρ) as inversion parameters in every iteration, and compared the final two FWI results.This research was supported by the Basic Research Project(17-3312) of the Korea Institute of

  17. Variable millimetre radiation from the colliding-wind binary Cygnus OB2 #8A

    Science.gov (United States)

    Blomme, R.; Fenech, D. M.; Prinja, R. K.; Pittard, J. M.; Morford, J. C.

    2017-12-01

    Context. Massive binaries have stellar winds that collide. In the colliding-wind region, various physically interesting processes occur, leading to enhanced X-ray emission, non-thermal radio emission, as well as non-thermal X-rays and gamma-rays. Non-thermal radio emission (due to synchrotron radiation) has so far been observed at centimetre wavelengths. At millimetre wavelengths, the stellar winds and the colliding-wind region emit more thermal free-free radiation, and it is expected that any non-thermal contribution will be difficult or impossible to detect. Aims: We aim to determine if the material in the colliding-wind region contributes substantially to the observed millimetre fluxes of a colliding-wind binary. We also try to distinguish the synchrotron emission from the free-free emission. Methods: We monitored the massive binary Cyg OB2 #8A at 3 mm with the NOrthern Extended Millimeter Array (NOEMA) interferometer of the Institut de Radioastronomie Millimétrique (IRAM). The data were collected in 14 separate observing runs (in 2014 and 2016), and provide good coverage of the orbital period. Results: The observed millimetre fluxes range between 1.1 and 2.3 mJy, and show phase-locked variability, clearly indicating that a large part of the emission is due to the colliding-wind region. A simple synchrotron model gives fluxes with the correct order of magnitude, but with a maximum that is phase-shifted with respect to the observations. Qualitatively this phase shift can be explained by our neglect of orbital motion on the shape of the colliding-wind region. A model using only free-free emission results in only a slightly worse explanation of the observations. Additionally, on the map of our observations we also detect the O6.5 III star Cyg OB2 #8B, for which we determine a 3 mm flux of 0.21 ± 0.033 mJy. Conclusions: The question of whether synchrotron radiation or free-free emission dominates the millimetre fluxes of Cyg OB2 #8A remains open. More detailed

  18. ObsPy: Establishing and maintaining an open-source community package

    Science.gov (United States)

    Krischer, L.; Megies, T.; Barsch, R.

    2017-12-01

    Python's ecosystem evolved into one of the most powerful and productive research environment across disciplines. ObsPy (https://obspy.org) is a fully community driven, open-source project dedicated to provide a bridge for seismology into that ecosystem. It does so by offering Read and write support for essentially every commonly used data format in seismology, Integrated access to the largest data centers, web services, and real-time data streams, A powerful signal processing toolbox tuned to the specific needs of seismologists, and Utility functionality like travel time calculations, geodetic functions, and data visualizations. ObsPy has been in constant unfunded development for more than eight years and is developed and used by scientists around the world with successful applications in all branches of seismology. By now around 70 people directly contributed code to ObsPy and we aim to make it a self-sustaining community project.This contributions focusses on several meta aspects of open-source software in science, in particular how we experienced them. During the panel we would like to discuss obvious questions like long-term sustainability with very limited to no funding, insufficient computer science training in many sciences, and gaining hard scientific credits for software development, but also the following questions: How to best deal with the fact that a lot of scientific software is very specialized thus usually solves a complex problem but at the same time can only ever reach a limited pool of developers and users by virtue of it being so specialized? Therefore the "many eyes on the code" approach to develop and improve open-source software only applies in a limited fashion. An initial publication for a significant new scientific software package is fairly straightforward. How to on-board and motivate potential new contributors when they can no longer be lured by a potential co-authorship? When is spending significant time and effort on reusable

  19. MODELING THE RADIO EMISSION FROM Cyg OB2 NO. 5: A QUADRUPLE SYSTEM?

    International Nuclear Information System (INIS)

    Kennedy, M.; Dougherty, S. M.; Fink, A.; Williams, P. M.

    2010-01-01

    Fifty observations at frequencies between 1.4 GHz and 43 GHz of the 6.6 day O6.5-7+O5.5-6 binary Cyg OB2 No. 5 using the Very Large Array over 20 years are re-examined. The aim is to determine the location and character of the previously detected variable radio emission. The radio emission from the system consists of a primary component that is associated with the binary, and a non-thermal source (NE), 0.''8 to the NE of the binary that has been ascribed to a wind-collision region (WCR) between the stellar winds of the binary and that of a B-type star (Star D) to the NE. Previous studies have not accounted for the potential contribution of NE to the total radio emission, most especially in observations where the primary and NE sources are not resolved as separate sources. NE shows no evidence of variation in 23 epochs where it is resolved separately from the primary radio component, demonstrating that the variable emission arises in the primary component. Since NE is non-variable, the radio flux from the primary can now be well determined for the first time, most especially in observations that do not resolve both the primary and NE components. The variable radio emission from the primary component has a period of 6.7 ± 0.3 years which is described by a simple model of a non-thermal source orbiting within the stellar wind envelope of the binary. Such a model implies the presence of a third, unresolved stellar companion (Star C) orbiting the 6.6 day binary with a period of 6.7 years and independent of Star D to the NE. The variable non-thermal emission arises from either a WCR between Star C and the binary system, or possibly from Star C directly. The model gives a mass-loss rate of 3.4 x 10 -5 M sun yr -1 for Cyg OB2 No. 5, unusually high for an Of supergiant and comparable to that of WR stars, and consistent with an unusually strong He I 1.083 μm emission line, also redolent of WR stars. An examination of radial velocity observations available from the

  20. A survey of formaldehyde in the Cepheus OB3 molecular cloud

    International Nuclear Information System (INIS)

    Few, R.W.; Cohen, R.J.

    1983-01-01

    The 1 11 - 1 10 absorption line of formaldehyde at 6-cm wavelength has been surveyed over the region of the Cepheus OB3 molecular cloud, using the Jodrell Bank Mk II radio telescope (beamwidth 9 x 10 arcmin 2 ). The measurements have a velocity resolution of 0.27 km s - 1 and an rms noise level of approx. 0.01 K. The formaldehyde has a very clumpy distribution which is broadly similar to the CO distribution found by Sargent. A total molecular mass of 1.9 x 10 4 solar masses is implied by the formaldehyde measurements. Cepheus A is not the dominant concentration in the formaldehyde map. The most massive formaldehyde concentration is Cepheus C, which has a mass of 3600 solar masses. It appears to be stabilized by rotation. (author)

  1. New Partner Recruitment to Rural Versus Urban Ob-Gyn Practices

    Directory of Open Access Journals (Sweden)

    Michael F. Fialkow

    2017-09-01

    Full Text Available Purpose: The purpose of this pilot study was to investigate the recruitment efforts of practicing obstetrics and gynecology (ob-gyns from rural and urban practices. Method: The authors surveyed practicing ob-gyns from 5 states in the Pacific Northwest in 2016 about their background, practice setting, practice profile, partner recruitment, and retention. Results: Seventy-three patients completed the study (53.2% response rate. Thirty-seven percent of respondents work in an urban practice and 43% have a rural practice, with the remainder in a suburban setting. A majority of the respondents attempted to recruit a new partner in the past 5 years. Respondents were most interested in experience and diversity in new recruits. Urban respondents, however, were more interested in hiring those with specialized skills (χ 2 = 7.842, P = .02 than rural providers who were more interested in partners familiar with their community (χ 2 = 7.153, P = .03. Reasons most often cited to leave their practice were reimbursement, limited social/marital options, and workload, other than rural providers who more often also cited lack of access to specialty care (χ 2 = 13.256, P = .001. Rural providers were more likely to cite marital and family status as an advantage to recruitment, whereas urban and suburban providers were more often neutral. Conclusions: Reduced access to care has led to significant health disparities for women living in rural communities. Understanding which providers are most likely to be successful in these settings might help preserve access as our health-care systems evolves.

  2. SCUBA and HIRES Results for Protostellar Cores in the MON OB1 Dark Cloud

    Science.gov (United States)

    Wolf-Chase, G.; Moriarty-Schieven, G.; Fich, M.; Barsony, M.

    1999-05-01

    We have used HIRES-processing of IRAS data and point-source modelling techniques (Hurt & Barsony 1996; O'Linger 1997; Barsony et al. 1998), together with submillimeter continuum imaging using the Submillimeter Common-User Bolometer Array (SCUBA) on the 15-meter James Clerk Maxwell Telescope (JCMT), to search CS cores in the Mon OB1 dark cloud (Wolf-Chase, Walker, & Lada 1995; Wolf-Chase & Walker 1995) for deeply embedded sources. These observations, as well as follow-up millimeter photometry at the National Radio Astronomy Observatory (NRAO) 12-meter telescope on Kitt Peak, have lead to the identification of two Class 0 protostellar candidates, which were previously unresolved from two brighter IRAS point sources (IRAS 06382+0939 & IRAS 06381+1039) in this cloud. Until now, only one Class 0 object had been confirmed in Mon OB1; the driving source of the highly-collimated outflow NGC 2264 G (Ward-Thompson, Eiroa, & Casali 1995; Margulis et al. 1990; Lada & Fich 1996), which lies well outside the extended CS cores. One of the new Class 0 candidates may be an intermediate-mass source associated with an H_2O maser, and the other object is a low-mass source which may be associated with a near-infrared jet, and possibly with a molecular outflow. We report accurate positions for the new Class 0 candidates, based on the SCUBA images, and present new SEDs for these sources, as well as for the brighter IRAS point sources. A portion of this work was performed while GWC held a President's Fellowship from the University of California. MB and GWC gratefully acknowledge financial support from MB's NSF CAREER Grant, AST97-9753229.

  3. Evaluating the probiotic and therapeutic potentials of Saccharomyces cerevisiae strain (OBS2) isolated from fermented nectar of toddy palm.

    Science.gov (United States)

    Srinivas, Banoth; Rani, Ganapathiwar Swarupa; Kumar, Bhukya Kiran; Chandrasekhar, Banoth; Krishna, Kommalapati Vamsi; Devi, Tangutur Anjana; Bhima, Bhukya

    2017-12-01

    The purpose of this study is to evaluate the probiotic characteristics of 15 yeast strains isolated from nectar of toddy palm. Initially, the collected samples were inoculated on yeast extract peptone dextrose agar plates and the colonies so obtained were culturally and morphologically characterized. Commercial probiotic yeast, Saccharomyces boulardii served as the control in these experiments. Of the 15 yeast strains, the isolates that were resistant to antibiotics and worked synergistically with other cultures were considered for further evaluation. Selected isolates were evaluated in vitro for tolerance to simulated gastrointestinal conditions such as temperature, pH, bile and gastric juice. Further the yeast isolates were evaluated for their pathogenicity and adherence to intestinal epithelial cells. The 2 yeast isolates with efficient probiotic properties were finally characterized by sequencing their 5.8 S rRNA and partial sequences of internal transcribed spacer 1 and 2. The sequences were BLAST searched in the National Center for Biotechnology Information, nucleic acid database for sequence similarity of organisms and phylogenetic evolutionary analysis was carried out. Based on maximum similarity of basic local alignment search tool results, organisms were characterized as Pichia kudriavzevii OBS1 (100%) and Saccharomyces cerevisiae OBS2 (96%) and sequences were finally deposited in the GenBank data library. Among these two isolates, S. cerevisiae OBS2 displayed slight/moderate antioxidant and anticancer property. Hence, strain OBS2 can be utilized and explored as a potential probiotic for therapeutic applications.

  4. Attenuation of S-waves in the lithosphere of the Sea of Crete according to OBS observations

    Science.gov (United States)

    Kovachev, S. A.; Kuzin, I. P.; Shoda, O. Yu.; Soloviev, S. L.

    1991-11-01

    Five OBS were installed in the Sea of Crete in 1987. During a period of nine days 430 local earthquakes were recorded. Hypocentres were determined for 85 microearthquakes. A correlation between magnitude ML and duration of seismic events on the records of the ocean bottom seismographs (OBS) was found from data of 14 shocks recorded simultaneously by OBS and some land-based Greek stations. A magnitude-frequency relationship for earthquakes recorded by OBS was obtained in the magnitude range ML = 2-4. Amplitude curves describing the attenuation of body waves in the lithosphere of the Sea of Crete were compiled. Assessment of quality factor Qs was made by comparison of empirical and theoretical amplitude curves. The values of Qs for the lithosphere of the Sea of Crete were calculated and found equal to 200-300. Low values of Qs and consequently strong attenuation of S-waves in the lithosphere of the Sea of Crete could be explained by extension of the lithosphere accompanied by its partial contamination with melted magma.

  5. Lutter contre l'obésité en Afrique du Sud à l'aide des politiques fiscales

    International Development Research Centre (IDRC) Digital Library (Canada)

    17 nov. 2016 ... En 2008, le fardeau total des maladies non transmissibles en Afrique du Sud était estimé à 40 %, et ne cessait de croître. L'obésité est un facteur de risque de plusieurs maladies non transmissibles, dont les cardiopathies, l'hypertension, le diabète et le cancer.

  6. B fields in OB stars (BOB): Low-resolution FORS2 spectropolarimetry of the first sample of 50 massive stars

    NARCIS (Netherlands)

    Fossati, L.; Castro, N.; Schöller, M.; Hubrig, S.; Langer, N.; Morel, T.; Briquet, M.; Herrero, A.; Przybilla, N.; Sana, H.; Schneider, F.R.N.; de Koter, A.

    2015-01-01

    Within the context of the collaboration "B fields in OB stars" (BOB), we used the FORS2 low-resolution spectropolarimeter to search for a magnetic field in 50 massive stars, including two reference magnetic massive stars. Because of the many controversies of magnetic field detections obtained with

  7. Case Study of Data Mining in Observational Astronomy: The Search for New OB Stars in the Small Magellanic Cloud

    Science.gov (United States)

    Larkin, Cormac; Vink, Jorick; Kalari, Venu; Groh, Jose

    2018-01-01

    OB stars are the most luminous and massive stars, living short lives and exerting a disproportionate influence on their environments. They are key to understanding progenitors of gravitational wave sources and reionization of the early Universe. To detect new OB stars, we combine photometric catalog data with TLUSTY and ATLAS9 stellar atmospheres. This method is also believed to be sensitive to elusive “stripped” stars, thought to lose their hydrogen envelope through binary interaction.OB stars are intrinsically luminous, so complete populations are assumed for local group galaxies such as the Small Magellanic Cloud. Our findings challenge this, as we find 26 new OB candidates. Spectroscopy of 7 candidates shows a 100% detection rate. Most interestingly, 5 of our candidates are consistent with “stripped” stars.To date only 5 “stripped” candidates have been found serendipitously (e.g. HD 45166) as current methods are not sensitive to them. Our work doubles the sample of detected candidates, highlighting that our approach is the first to identify them in a targeted, systematic way. The finding of “stripped” stars could rewrite our understanding of the early Universe, offering an alternative hypothesis to Wolf-Rayet driven cosmic reionization.

  8. Structure-guided mutational analysis of the OB, HhH, and BRCT domains of Escherichia coli DNA ligase.

    Science.gov (United States)

    Wang, Li Kai; Nair, Pravin A; Shuman, Stewart

    2008-08-22

    NAD(+)-dependent DNA ligases (LigAs) are ubiquitous in bacteria and essential for growth. LigA enzymes have a modular structure in which a central catalytic core composed of nucleotidyltransferase and oligonucleotide-binding (OB) domains is linked via a tetracysteine zinc finger to distal helix-hairpin-helix (HhH) and BRCT (BRCA1-like C-terminal) domains. The OB and HhH domains contribute prominently to the protein clamp formed by LigA around nicked duplex DNA. Here we conducted a structure-function analysis of the OB and HhH domains of Escherichia coli LigA by alanine scanning and conservative substitutions, entailing 43 mutations at 22 amino acids. We thereby identified essential functional groups in the OB domain that engage the DNA phosphodiester backbone flanking the nick (Arg(333)); penetrate the minor grove and distort the nick (Val(383) and Ile(384)); or stabilize the OB fold (Arg(379)). The essential constituents of the HhH domain include: four glycines (Gly(455), Gly(489), Gly(521), Gly(553)), which bind the phosphate backbone across the minor groove at the outer margins of the LigA-DNA interface; Arg(487), which penetrates the minor groove at the outer margin on the 3 (R)-OH side of the nick; and Arg(446), which promotes protein clamp formation via contacts to the nucleotidyltransferase domain. We find that the BRCT domain is required in its entirety for effective nick sealing and AMP-dependent supercoil relaxation.

  9. Methanobactin from Methylocystis sp. strain SB2 affects gene expression and methane monooxygenase activity in Methylosinus trichosporium OB3b.

    Science.gov (United States)

    Farhan Ul-Haque, Muhammad; Kalidass, Bhagyalakshmi; Vorobev, Alexey; Baral, Bipin S; DiSpirito, Alan A; Semrau, Jeremy D

    2015-04-01

    Methanotrophs can express a cytoplasmic (soluble) methane monooxygenase (sMMO) or membrane-bound (particulate) methane monooxygenase (pMMO). Expression of these MMOs is strongly regulated by the availability of copper. Many methanotrophs have been found to synthesize a novel compound, methanobactin (Mb), that is responsible for the uptake of copper, and methanobactin produced by Methylosinus trichosporium OB3b plays a key role in controlling expression of MMO genes in this strain. As all known forms of methanobactin are structurally similar, it was hypothesized that methanobactin from one methanotroph may alter gene expression in another. When Methylosinus trichosporium OB3b was grown in the presence of 1 μM CuCl2, expression of mmoX, encoding a subunit of the hydroxylase component of sMMO, was very low. mmoX expression increased, however, when methanobactin from Methylocystis sp. strain SB2 (SB2-Mb) was added, as did whole-cell sMMO activity, but there was no significant change in the amount of copper associated with M. trichosporium OB3b. If M. trichosporium OB3b was grown in the absence of CuCl2, the mmoX expression level was high but decreased by several orders of magnitude if copper prebound to SB2-Mb (Cu-SB2-Mb) was added, and biomass-associated copper was increased. Exposure of Methylosinus trichosporium OB3b to SB2-Mb had no effect on expression of mbnA, encoding the polypeptide precursor of methanobactin in either the presence or absence of CuCl2. mbnA expression, however, was reduced when Cu-SB2-Mb was added in both the absence and presence of CuCl2. These data suggest that methanobactin acts as a general signaling molecule in methanotrophs and that methanobactin "piracy" may be commonplace. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  10. Constraining formation of the Eggvin Bank (West of Jan Mayen, N. Atlantic) from OBS data

    Science.gov (United States)

    Tan, P.; Breivik, A. J.; Mjelde, R.; Azuma, R.

    2015-12-01

    The anomalously high magma flux in the Eggvin Bank area has triggered new research efforts to better understand the crustal development in this area. The Eggvin Bank is located between the Jan Mayen Island and the west coast of Greenland. Some proposed origins of the Eggvin Bank are: a distinct plume located beneath Jan Mayen; an extension of the Iceland plume; minor spreading or leakage along West Jan Mayen Fracture Zone (WJMFZ); intruded continental crust extending from Jan Mayen Microcontinent (JMMC); and rifted Greenland sub-continental lithospheric mantle. In this first modern refraction seismic study of the Eggvin Bank, we present a 2D velocity model based on OBS data. The OBSs were deployed approx. N-S over the Eggvin Bank with good data quality constrained by 4 OBSs. The air-gun array used during OBS shooting produced good quality reflection data. Three distinct seamounts are observed along the profile: the northern seamount (water depth 730m), has a flat top with a thin sedimentary veneer on top, which indicates it has been eroded at sea surface; while the southern two seamounts, one (water depth 550m) is less flat with around 100m thick sedimentary units on top, another one is rounded with tiny sedimentary veneer on top having the shallowest water depth (460m). This could suggest that the southern seamounts are younger, since they are shallower but without obvious signs that they were subaerially exposed. However, increased cooling of the lithosphere across the WJMFZ in the north may also contribute to depth differences. A normal fault offsetting sedimentary strata (~300 m) in the Greenland Basin indicates recent tectonic activity north of the Eggvin Bank. The velocity modeling shows crustal thickness with large variations, ranging from 8 km to 14 km, where crustal thickness changes of 4-5 km are associated with 20-30 km wide segments with thick crust under the seamounts. The crust consists of three oceanic crustal layers: upper crust (2.8km/s-4.8km

  11. Plutonium speciation and isotope ratios in Yenisey and Ob river and Yenisey estuary

    International Nuclear Information System (INIS)

    Skipperud, L.; Oughton, DH.; Fifield, K.; Lind, O.C.; Salbu, B.; Brown, J.

    2004-01-01

    Plutonium isotope ratios are known to vary with reactor type, nuclear fuel-burn up time, neutron flux, and energy, and for fallout from nuclear detonations, weapon type and yield. Weapons-grade plutonium is characterized by a low content of the 240 Pu isotope, with 240 Pu/ 239 Pu isotope ratio less than 0.05. In contrast, both global weapons fallout and spent nuclear fuel from civil reactors have higher 240 Pu/ 239 Pu isotope ratios (civil nuclear power reactors have 240 Pu/ 239 Pu atom ratios of between about 0.2-1). Thus, different sources often exhibit characteristic plutonium isotope ratios and these ratios can be used to identify the origin of contamination, calculate inventories, or follow the migration of contaminated sediments and waters. Together with activity measurements and isotope ratios, knowledge of plutonium speciation in the Ob and Yenisey rivers and processes controlling its behaviour in estuarine systems is a prerequisite for predicting the transfer and subsequent environmental impact to Arctic Seas. With this in mind, the study had two objectives: first to determine whether discharges from nuclear installations in the river catchment areas are having any influence on Pu levels in the estuaries; and, second, to investigate the transfer and mobility of plutonium in the Yenisey river and estuary. Plutonium 240/239 ratios were determined using accelerator mass spectrometry (AMS). The data indicated a clear influence from a low 240 Pu: 239 Pu source in surface sediments collected from the Yenisey Estuary, whereas plutonium in the Ob Estuary sediments are dominated by global fallout. The results also show an increase in plutonium concentration and a decrease in isotope ratio going upstream from the estuary. Sequential extractions of sediments indicate that up 70% of the Pu in the Yenisey river is easily mobilized with weak oxidizing agents, which indicates that the Pu is organically bound, while the Pu is more strongly irreversible bound further out

  12. Polimorfismos del gen ob en bovinos de raza holstein en la Comarca Lagunera, México

    Directory of Open Access Journals (Sweden)

    Sarai S. Mendoza-Retana

    2017-01-01

    Full Text Available La Comarca Lagunera es la cuenca lechera más importante de México. En la actualidad se están utilizando diversas técnicas que permiten evaluar genéticamente el animal a una edad temprana, permitiendo seleccionar futuros reproductores con características deseables. Entre los genes relacionados con la producción de leche, se encuentran el gen Ob también llamado gen Leptina el cual actúa sobre el sistema nervioso central y tejidos periféricos jugando un papel muy importante en la modulación regulación del apetito, ganancia de peso vivo, incremento del metabolismo energético y el anabolismo muscular. Este trabajo se realizó para determinar el polimorfismo de longitud del fragmento de restricción ACI I de gen leptina en el exón 2 y correlacionarlo con los parámetros de producción y calidad de leche. Se recolectaron 100 muestra de sangre de vacas en producción del establo “Lácteos Florida” de Francisco I. Madero municipio de Coahuila, México con tres esta tus de producción: altas, medias y bajas La extracción de ADN se realizó por el método modificado de Salting - Out. Se realizó PCR del gen leptina originando un fragmento de 272 bp de longitud y se realizó PCR - RFLP con la enzima de restricción ACI I y secue nciación, correlacionando los genotipos TT, CT Y CC con tres estatus de producción de leche: altas, medias, bajas. El análisis estadístico indicó que las vacas portadoras del genotipo homocigoto (TT tienen un efecto significativo (P<0.01 con respecto a l as características de producción y calidad de leche ya que tuvieron un mayor consumo de alimento, ganancia de peso, además de una elevada producción de leche en comparación a los genotipos heterocigoto (CT y homocigoto (CC. Los resultados obtenidos muest ran que l a identificación molecular de polimorfismos del gen Ob puede usarse como herramienta de selección genética en bovinos de raza Holstein.

  13. A Deuteration Survey of Starless Clumps in GemOB1 and the First Quadrant

    Science.gov (United States)

    Henrici, Andrew; Shirley, Yancy L.; Svoboda, Brian

    2018-01-01

    One very strong chemical process in star-forming regions is the fractionation of deuterium in molecules, which results in an increase in the deuterium ratio many orders of magnitude over the ISM [D]/[H] ratio and provides a chemical probe of cold, dense regions. Recent maps of dust continuum emission at (sub)millimeter wavelengths have identified tens of thousands of dense clumps of gas and dust. By comparing these regions to infrared and radio surveys, we have identified starless clump candidates which have no evidence for embedded star formation. These objects represent the earliest phase of star formation throughout the Milky Way. One benefit of the Milky Way surveys is that it is also possible to study the chemistry of entire core and clump populations within a single cloud. We used the 10m Heinrich Hertz Submillimeter Telescope to survey starless clump candidates in the First Quadrant identified from the Bolocam Galactic Plane Survey 1.1 mm continuum in the deuterated molecular transitions of DCO+ 3-2 and N2D+ 3-2. We also survey the entire clump population of the Gemini OB1 molecular cloud. In both surveys, we compared detection statistics and compare deuteration fraction to physical properties of the clumps and their evolutionary stage. High resolution ALMA observations of 9 starless clump candidates of the same lines are used to analyze how the cold deuterated gas is spatially distributed in these clumps.

  14. New Version of SeismicHandler (SHX) based on ObsPy

    Science.gov (United States)

    Stammler, Klaus; Walther, Marcus

    2016-04-01

    The command line version of SeismicHandler (SH), a scientific analysis tool for seismic waveform data developed around 1990, has been redesigned in the recent years, based on a project funded by the Deutsche Forschungsgemeinschaft (DFG). The aim was to address new data access techniques, simplified metadata handling and a modularized software design. As a result the program was rewritten in Python in its main parts, taking advantage of simplicity of this script language and its variety of well developed software libraries, including ObsPy. SHX provides an easy access to waveforms and metadata via arclink and FDSN webservice protocols, also access to event catalogs is implemented. With single commands whole networks or stations within a certain area may be read in, the metadata are retrieved from the servers and stored in a local database. For data processing the large set of SH commands is available, as well as the SH scripting language. Via this SH language scripts or additional Python modules the command set of SHX is easily extendable. The program is open source, tested on Linux operating systems, documentation and download is found at URL "https://www.seismic-handler.org/".

  15. Targeting the OB-Folds of Replication Protein A with Small Molecules

    Directory of Open Access Journals (Sweden)

    Victor J. Anciano Granadillo

    2010-01-01

    Full Text Available Replication protein A (RPA is the main eukaryotic single-strand (ss DNA-binding protein involved in DNA replication and repair. We have identified and developed two classes of small molecule inhibitors (SMIs that show in vitro inhibition of the RPA-DNA interaction. We present further characterization of these SMIs with respect to their target binding, mechanism of action, and specificity. Both reversible and irreversible modes of inhibition are observed for the different classes of SMIs with one class found to specifically interact with DNA-binding domains A and B (DBD-A/B of RPA. In comparison with other oligonucleotide/oligosaccharide binding-fold (OB-fold containing ssDNA-binding proteins, one class of SMIs displayed specificity for the RPA protein. Together these data demonstrate that the specific targeting of a protein-DNA interaction can be exploited towards interrogating the cellular activity of RPA as well as increasing the efficacy of DNA-damaging chemotherapeutics used in cancer treatment.

  16. Measurement of Circumstellar Disk Sizes in the Upper Scorpius OB Association with ALMA

    Science.gov (United States)

    Barenfeld, Scott A.; Carpenter, John M.; Sargent, Anneila I.; Isella, Andrea; Ricci, Luca

    2017-12-01

    We present detailed modeling of the spatial distributions of gas and dust in 57 circumstellar disks in the Upper Scorpius OB Association observed with ALMA at submillimeter wavelengths. We fit power-law models to the dust surface density and CO J = 3–2 surface brightness to measure the radial extent of dust and gas in these disks. We found that these disks are extremely compact: the 25 highest signal-to-noise disks have a median dust outer radius of 21 au, assuming an {R}-1 dust surface density profile. Our lack of CO detections in the majority of our sample is consistent with these small disk sizes assuming the dust and CO share the same spatial distribution. Of seven disks in our sample with well-constrained dust and CO radii, four appear to be more extended in CO, although this may simply be due to the higher optical depth of the CO. Comparison of the Upper Sco results with recent analyses of disks in Taurus, Ophiuchus, and Lupus suggests that the dust disks in Upper Sco may be approximately three times smaller in size than their younger counterparts, although we caution that a more uniform analysis of the data across all regions is needed. We discuss the implications of these results for disk evolution.

  17. SPITZER IRS SPECTRA OF DEBRIS DISKS IN THE SCORPIUS–CENTAURUS OB ASSOCIATION

    Energy Technology Data Exchange (ETDEWEB)

    Jang-Condell, Hannah [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82071 (United States); Chen, Christine H.; Mittal, Tushar; Lisse, Carey M. [Space Telescope Science Institute, 3700 San Martin Dr., Baltimore, MD 21218 (United States); Manoj, P. [Department of Astronomy and Astrophysics, Tata Institute of Fundamental Research, Homi Bhabha Rd., Mumbai 400005 (India); Watson, Dan [Department of Physics and Astronomy, University of Rochester, Rochester, NY 14627 (United States); Nesvold, Erika; Kuchner, Marc [NASA Goddard Space Flight Center, Greenbelt, MD (United States)

    2015-08-01

    We analyze spectra obtained with the Spitzer Infrared Spectrograph (IRS) of 110 B-, A-, F-, and G-type stars with optically thin infrared excess in the Scorpius–Centaurus OB association. The ages of these stars range from 11 to 17 Myr. We fit the infrared excesses observed in these sources by Spitzer IRS and the Multiband Imaging Photometer for Spitzer (MIPS) to simple dust models according to Mie theory. We find that nearly all of the objects in our study can be fit by one or two belts of dust. Dust around lower mass stars appears to be closer in than around higher mass stars, particularly for the warm dust component in the two-belt systems, suggesting a mass-dependent evolution of debris disks around young stars. For those objects with stellar companions, all dust distances are consistent with truncation of the debris disk by the binary companion. The gaps between several of the two-belt systems can place limits on the planets that might lie between the belts, potentially constraining the mass and locations of planets that may be forming around these stars.

  18. An ALMA continuum survey of circumstellar disks in the upper Scorpius OB association

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, John M.; Ricci, Luca; Isella, Andrea [Department of Astronomy, California Institute of Technology, MC 249-17, Pasadena, CA 91125 (United States)

    2014-05-20

    We present ALMA 880 μm continuum observations of 20 K- and M-type stars in the Upper Scorpius OB association (Upper Sco) that are surrounded by protoplanetary disks. These data are used to measure the dust content in disks around low-mass stars (0.1-1.6 M {sub ☉}) at a stellar age of 5-11 Myr. Thirteen sources were detected in the 880 μm dust continuum at ≥3σ with inferred dust masses between 0.3 and 52 M {sub ⊕}. The dust masses tend to be higher around the more massive stars, but the significance is marginal in that the probability of no correlation is p ≈ 0.03. The evolution in the dust content in disks was assessed by comparing the Upper Sco observations with published continuum measurements of disks around ∼1-2 Myr stars in the Class II stage in the Taurus molecular cloud. While the dust masses in the Upper Sco disks are on average lower than in Taurus, any difference in the dust mass distributions is significant at less than 3σ. For stellar masses between 0.49 M {sub ☉} and 1.6 M {sub ☉}, the mean dust mass in disks is lower in Upper Sco relative to Taurus by Δlog M {sub dust} = 0.44 ± 0.26.

  19. Central stars of planetary nebulae. II. New OB-type and emission-line stars

    Science.gov (United States)

    Weidmann, W. A.; Gamen, R.

    2011-07-01

    Context. There are more than 3000 confirmed and probably known Galactic planetary nebulae (PNe), but central star spectroscopic information is available for only 13% of them. Aims: We have undertaken a spectroscopic survey of the central stars in PNe to identify their spectral types. Methods: We performed spectroscopic observations at low resolution with the 2-m telescope at CASLEO, Argentina. Results: We present the spectra of 46 central stars of PNe, most of them are OB-type and emission-line stars. Based on data collected at the Complejo Astronómico El Leoncito (CASLEO), which is operated under agreement between the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina y Universidades Nacionales de La Plata, Córdoba y San Juan, Argentina.The reduced spectra (FITS files) are available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/531/A172

  20. DIRECT IMAGING AND SPECTROSCOPY OF A YOUNG EXTRASOLAR KUIPER BELT IN THE NEAREST OB ASSOCIATION

    International Nuclear Information System (INIS)

    Currie, Thayne; Lisse, Carey M.; Kuchner, Marc; Madhusudhan, Nikku; Kenyon, Scott J.; Thalmann, Christian; Carson, Joseph; Debes, John

    2015-01-01

    We describe the discovery of a bright, young Kuiper belt–like debris disk around HD 115600, a ∼1.4–1.5 M ⊙ , ∼15 Myr old member of the Sco–Cen OB Association. Our H-band coronagraphy/integral field spectroscopy from the Gemini Planet Imager shows the ring has a (luminosity-scaled) semimajor axis of (∼22 AU) ∼ 48 AU, similar to the current Kuiper belt. The disk appears to have neutral-scattering dust, is eccentric (e ∼ 0.1–0.2), and could be sculpted by analogs to the outer solar system planets. Spectroscopy of the disk ansae reveal a slightly blue to gray disk color, consistent with major Kuiper belt chemical constituents, where water ice is a very plausible dominant constituent. Besides being the first object discovered with the next generation of extreme adaptive optics systems (i.e., SCExAO, GPI, SPHERE), HD 115600's debris ring and planetary system provide a key reference point for the early evolution of the solar system, the structure, and composition of the Kuiper belt and the interaction between debris disks and planets

  1. DIRECT IMAGING AND SPECTROSCOPY OF A YOUNG EXTRASOLAR KUIPER BELT IN THE NEAREST OB ASSOCIATION

    Energy Technology Data Exchange (ETDEWEB)

    Currie, Thayne [National Astronomical Observatory of Japan, Subaru Telescope, Hilo, HI (United States); Lisse, Carey M. [Applied Physics Laboratory, The Johns Hopkins University, Laurel, MD (United States); Kuchner, Marc [NASA Goddard Space Flight Center, Greenbelt, MD (United States); Madhusudhan, Nikku [Institute for Astronomy, University of Cambridge, Cambridge (United Kingdom); Kenyon, Scott J. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA (United States); Thalmann, Christian [ETH-Zurich, Zurich (Switzerland); Carson, Joseph [Department of Physics and Astronomy, The College of Charleston, Charleston, SC (United States); Debes, John [Space Telescope Science Institute, Baltimore, MD (United States)

    2015-07-01

    We describe the discovery of a bright, young Kuiper belt–like debris disk around HD 115600, a ∼1.4–1.5 M{sub ⊙}, ∼15 Myr old member of the Sco–Cen OB Association. Our H-band coronagraphy/integral field spectroscopy from the Gemini Planet Imager shows the ring has a (luminosity-scaled) semimajor axis of (∼22 AU) ∼ 48 AU, similar to the current Kuiper belt. The disk appears to have neutral-scattering dust, is eccentric (e ∼ 0.1–0.2), and could be sculpted by analogs to the outer solar system planets. Spectroscopy of the disk ansae reveal a slightly blue to gray disk color, consistent with major Kuiper belt chemical constituents, where water ice is a very plausible dominant constituent. Besides being the first object discovered with the next generation of extreme adaptive optics systems (i.e., SCExAO, GPI, SPHERE), HD 115600's debris ring and planetary system provide a key reference point for the early evolution of the solar system, the structure, and composition of the Kuiper belt and the interaction between debris disks and planets.

  2. As assessment of the flux of radionuclide contamination through the Ob and Yenisei rivers and estuaries to the Kara Sea

    International Nuclear Information System (INIS)

    Pauluszkiewicz, T.; Hibler, L.F.; Richmond, M.C.; Bradley, D.J.

    1995-01-01

    Recent data indicate that there are potentially large sources of radionuclide contamination on the Ob River system. To quantify the existing radionuclide contamination from a possible catastrophic event data and models have been used to quantify scenarios. Using a compilation of Russian data on the radionuclide contamination, hydrologic data and studies on the sediment transport process a conceptual model has been developed of the Ob system, and a numerical model has been applied to estimate the radionuclide flux to the Kara Sea. The initial results of the river modeling in the Mayak region show how important watershed flow from the marshes are to the hydrologic budget of the area. The preliminary analysis of the sediment flux indicates the need to consider the depositional (storage) regions such as the Asanow Marsh. 31 refs., 5 figs

  3. Growth of yttrium iron garnet single crystals in Na2O-B2O3 flux system in air

    International Nuclear Information System (INIS)

    Bandyopadhyay, Tarun; Saha, Prasenjit

    1977-01-01

    Detailed studies of growth of yttrium iron garnet (YIG) in the flux system Na 2 O-B 2 O 3 were made to delineate the phase stability regions of YIG and the neighbouring crystalline phases, and a tentative working diagram of Na 2 O-B 2 O 3 -YIG in air was drawn from the results of small batch crystal growth runs and solubility studies. The occurrence of a rather narrow field of YIG crystallization in this system was explained on the basis of relative solubilities of different oxides constituting YIG. Several long-time growth runs with some typical compositions were carried out in this system to evaluate its suitability for bulk growth of YIG crystals. The system, although possessing some inherent advantages, was found to suffer from limitations because the maximum size of the self-nucleated crystals grown hardly exceeded 2.00 mm. (author)

  4. Réduire l'obésité chez les enfants au Mexique | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    27 avr. 2016 ... ... le Mexique connaît une « transition nutritionnelle » sous l'effet des changements qui se sont produits en ce qui concerne le régime alimentaire, la nutrition et l'activité physique. Le surpoids et l'obésité sont des facteurs de risque pour les maladies chroniques comme le diabète et le cancer, sans compter ...

  5. De la ferme à la fourchette – lutte contre l'obésité chez les enfants ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    26 avr. 2016 ... ... but de combattre l'obésité chez les enfants. La démarche repose sur trois piliers, à savoir augmenter la proportion de fruits et de légumes frais dans les repas servis à l'école, faciliter l'approvisionnement en produits auprès des agriculteurs locaux et favoriser l'augmentation de la production maraîchère.

  6. Adipokines : rôle dans l’obésité et l’insulino‐résistance

    Directory of Open Access Journals (Sweden)

    Aubert Roberte

    2003-03-01

    Full Text Available Le tissu adipeux longtemps considéré comme un organe de stockage est maintenant reconnu comme un organe endocrine. Cette revue étudie l’action de 3 adipokines sécrétées par le tissu adipeux et impliquées dans le contrôle de l’homéostasie énergétique et l’insulino‐résistance, la leptine, l’adiponectine et la résistine. La découverte de la leptine a permis la compréhension des mécanismes centraux de la prise alimentaire et de la dépense énergétique. L’espoir que la leptine puisse intervenir dans le traitement de l’obésité a été déçu, mais elle joue un rôle important dans l’insulino‐sensibilité. L’adiponectine circulante est diminuée dans l’obésité et la perte pondérale augmente son taux. Elle améliore la sensibilité à l’insuline en agissant sur le métabolisme glucidique et lipidique. Bien que pour le moment le rôle de la résistine soit encore mal défini, les études chez l’animal suggèrent qu’elle soit impliqués dans l’insulino‐résistance. Chez l’homme il n’y a pas de relation entre l’expression de la résistine et l’obésité. On peut donc se demander si la résistine, dans l’espèce humaine, est bien le lien entre obésité et diabète de type 2.

  7. Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7

    Energy Technology Data Exchange (ETDEWEB)

    Duggirala, R.; Stern, M.P.; Reinhart, L.J. [Univ. of Texas Health Science Center, San Antonio, TX (United States)] [and others

    1996-09-01

    Despite the evidence that human obesity has strong genetic determinants, efforts at identifying specific genes that influence human obesity have largely been unsuccessful. Using the sibship data obtained from 32 low-income Mexican American pedigrees ascertained on a type II diabetic proband and a multipoint variance-components method, we tested for linkage between various obesity-related traits plus associated metabolic traits and 15 markers on human chromosome 7. We found evidence for linkage between markers in the OB gene region and various traits, as follows: D7S514 and extremity skinfolds (LOD = 3.1), human carboxypeptidase A1 (HCPA1) and 32,33-split proinsulin level (LOD = 4.2), and HCPA1 and proinsulin level (LOD = 3.2). A putative susceptibility locus linked to the marker D7S514 explained 56% of the total phenotypic variation in extremity skinfolds. Variation at the HCPA1 locus explained 64% of phenotypic variation in proinsulin level and {approximately}73% of phenotypic variation in split proinsulin concentration, respectively. Weaker evidence for linkage to several other obesity-related traits (e.g., waist circumference, body-mass index, fat mass by bioimpedance, etc.) was observed for a genetic location, which is {approximately}15 cM telomeric to OB. In conclusion, our study reveals that the OB region plays a significant role in determining the phenotypic variation of both insulin precursors and obesity-related traits, at least in Mexican Americans. 66 refs., 3 figs., 4 tabs.

  8. An anomalous extinction law in the Cep OB3b young cluster: Evidence for dust processing during gas dispersal

    International Nuclear Information System (INIS)

    Allen, Thomas S.; Prchlik, Jakub J.; Megeath, S. Thomas; Gutermuth, Robert A.; Pipher, Judith L.; Naylor, Tim; Jeffries, R. D.

    2014-01-01

    We determine the extinction law through Cep OB3b, a young cluster of 3000 stars undergoing gas dispersal. The extinction is measured toward 76 background K giants identified with MMT/Hectospec spectra. Color excess ratios were determined toward each of the giants using V and R photometry from the literature, g, r, i, and z photometry from the Sloan Digital Sky Survey and J, H, and K s photometry from the Two Micron All Sky Survey. These color excess ratios were then used to construct the extinction law through the dusty material associated with Cep OB3b. The extinction law through Cep OB3b is intermediate between the R V = 3.1 and R V = 5 laws commonly used for the diffuse atomic interstellar medium and dense molecular clouds, respectively. The dependence of the extinction law on line-of-sight A V is investigated and we find the extinction law becomes shallower for regions with A V > 2.5 mag. We speculate that the intermediate dust law results from dust processing during the dispersal of the molecular cloud by the cluster.

  9. An anomalous extinction law in the Cep OB3b young cluster: Evidence for dust processing during gas dispersal

    Energy Technology Data Exchange (ETDEWEB)

    Allen, Thomas S.; Prchlik, Jakub J.; Megeath, S. Thomas [University of Toledo, Ritter Astrophysical Observatory, Department of Physics and Astronomy, Toledo, OH 43606 (United States); Gutermuth, Robert A. [Five College Astronomy Department, Smith College, Northampton, MA 01063 (United States); Pipher, Judith L. [Department of Physics and Astronomy, University of Rochester, Rochester, NY 14627 (United States); Naylor, Tim [School of Physics, University of Exeter, Exeter, UK EX4 4QL (United Kingdom); Jeffries, R. D. [Astrophysics Group, School of Physical and Geographical Sciences, Keele University, Keele, Staffordshire, UK ST5 5BG (United Kingdom)

    2014-05-10

    We determine the extinction law through Cep OB3b, a young cluster of 3000 stars undergoing gas dispersal. The extinction is measured toward 76 background K giants identified with MMT/Hectospec spectra. Color excess ratios were determined toward each of the giants using V and R photometry from the literature, g, r, i, and z photometry from the Sloan Digital Sky Survey and J, H, and K{sub s} photometry from the Two Micron All Sky Survey. These color excess ratios were then used to construct the extinction law through the dusty material associated with Cep OB3b. The extinction law through Cep OB3b is intermediate between the R{sub V} = 3.1 and R{sub V} = 5 laws commonly used for the diffuse atomic interstellar medium and dense molecular clouds, respectively. The dependence of the extinction law on line-of-sight A{sub V} is investigated and we find the extinction law becomes shallower for regions with A{sub V} > 2.5 mag. We speculate that the intermediate dust law results from dust processing during the dispersal of the molecular cloud by the cluster.

  10. Comparison of the biometric measurements calculated with Zeiss IOL-Master and WaveLight OB-820

    Directory of Open Access Journals (Sweden)

    Labiris G

    2017-04-01

    Full Text Available Georgios Labiris,1,2 Panagiota Ntonti,2 Konstantinos Ntitsos,2 Andreas Katsanos,2 Haris Sideroudi,2 Vasilios Kozobolis1,2 1Department of Ophthalmology, University Hospital of Alexandroupolis, 2Eye Institute of Thrace, Alexandroupolis, Greece Background: The primary objective of this study was to investigate the level of agreement between IOL-Master and OB-820 ocular biometers.Materials and methods: In this prospective randomized case series, we measured the anterior chamber depth (ACD, the axial length (AL, the corneal radii (R1, R2, the ratio of mean corneal radius and spherical equivalent and the corneal astigmatism (cylinder [Cyl] before and after cataract extraction surgery.Results: Significant differences between pre- and postoperative data were observed for ACD for both biometric devices (P<0.01 and Cyl parameter in IOL-Master. Range and 95% limits of agreement (LoA were clinically significantly different for AL parameter pre- and postoperatively and for R2 and radius and spherical equivalent postoperatively (P<0.001. The rest of the parameters presented sufficient 95% LoA, which imply good agreement.Conclusion: In clinical practice, the IOL-master and OB-820 should not be used interchangeably due to discrepancy in the important AL parameter. Both biometers may provide consistent results regarding Cyl, ACD and R1. Keywords: cataract, IOL-Master, OB-820, biometry, level of agreement

  11. Triggering risk factors of the burnout syndrome in OB/GYN physicians from a reference public university of Brazil.

    Science.gov (United States)

    Ferreira Bortoletti, Fátima; Teresa Benevides-Pereira, Ana Maria; Vasconcellos, Esdras Guerreiro; Siqueira, José Oliveira; Araujo Júnior, Edward; Nardozza, Luciano Marcondes Machado; Sebastiani, Ricardo Werner; Moron, Antonio Fernandes

    2012-01-01

    Objective. To identify the risk factors to the development of Burnout Syndrome in Ob/Gyn Brazilian physicians in four dimensions: emotional exhaustion (EE), professional repression (PR), dehumanization (De), and emotional distancing (EmD). Methods. A prospective cross-sectional study was realized with 48 Ob/Gyn physicians (12 lecturers, 12 attending physicians, 12 medical residents, and 12 graduate students) from Department of Obstetrics, São Paulo Federal University (UNIFESP). We used a sociodemographic questionnaire focusing on the activities (administrative, educational, healthcare, and research). We applied a Burnout Syndrome Inventory (BSI) composed of two parts: triggering factors (ISB1) and the Burnout Syndrome (ISB2). The ISB1 is composed of two scales: positive organizational conditions (POC) and negative organizational conditions (NOC). The ISB2 is composed of four scales: EE, PR, De, and EmD. Results. We observed a rate below and above average to POC and NOC, respectively. The dimensions recorded a level above average to EE, an index at the upper limit of the average to De, a median index to EmD, and a median index to PR. Conclusions. The Ob/Gyn physicians are in an area of vulnerability for the development of Burnout Syndrome due to the high level of EE and De, associated with a median index of PR. The high rate of NOC contributes to the triggering of this scenery.

  12. CARINA OB STARS: X-RAY SIGNATURES OF WIND SHOCKS AND MAGNETIC FIELDS

    International Nuclear Information System (INIS)

    Gagne, Marc; Fehon, Garrett; Savoy, Michael R.; Cohen, David H.; Townsley, Leisa K.; Broos, Patrick S.; Povich, Matthew S.; Corcoran, Michael F.; Walborn, Nolan R.; Remage Evans, Nancy; Moffat, Anthony F. J.; Naze, Yael; Oskinova, Lida M.

    2011-01-01

    The Chandra Carina Complex contains 200 known O- and B-type stars. The Chandra survey detected 68 of the 70 O stars and 61 of 127 known B0-B3 stars. We have assembled a publicly available optical/X-ray database to identify OB stars that depart from the canonical L X /L bol relation or whose average X-ray temperatures exceed 1 keV. Among the single O stars with high kT we identify two candidate magnetically confined wind shock sources: Tr16-22, O8.5 V, and LS 1865, O8.5 V((f)). The O4 III(fc) star HD 93250 exhibits strong, hard, variable X-rays, suggesting that it may be a massive binary with a period of >30 days. The visual O2 If* binary HD 93129A shows soft 0.6 keV and hard 1.9 keV emission components, suggesting embedded wind shocks close to the O2 If* Aa primary and colliding wind shocks between Aa and Ab. Of the 11 known O-type spectroscopic binaries, the long orbital-period systems HD 93343, HD 93403, and QZ Car have higher shock temperatures than short-period systems such as HD 93205 and FO 15. Although the X-rays from most B stars may be produced in the coronae of unseen, low-mass pre-main-sequence companions, a dozen B stars with high L X cannot be explained by a distribution of unseen companions. One of these, SS73 24 in the Treasure Chest cluster, is a new candidate Herbig Be star.

  13. Seismic velocity variation along the Izu-Bonin arc estaimated from traveltime tomography using OBS data

    Science.gov (United States)

    Obana, K.; Tamura, Y.; Takahashi, T.; Kodaira, S.

    2014-12-01

    The Izu-Bonin (Ogasawara) arc is an intra-oceanic island arc along the convergent plate boundary between the subducting Pacific and overriding Philippine Sea plates. Recent active seismic studies in the Izu-Bonin arc reveal significant along-arc variations in crustal structure [Kodaira et al., 2007]. The thickness of the arc crust shows a remarkable change between thicker Izu (~30 km) and thinner Bonin (~10 km) arcs. In addition to this, several geological and geophysical contrasts, such as seafloor topography and chemical composition of volcanic rocks, between Izu and Bonin arc have been reported [e.g., Yuasa 1992]. We have conducted earthquake observations using ocean bottom seismographs (OBSs) to reveal seismic velocity structure of the crust and mantle wedge in the Izu-Bonin arc and to investigate origin of the along-arc structure variations. We deployed 40 short-period OBSs in Izu and Bonin area in 2006 and 2009, respectively. The OBS data were processed with seismic data recorded at routine seismic stations on Hachijo-jima, Aoga-shima, and Chichi-jima operated by National Research Institute for Earth Science and Disaster Prevention (NIED). More than 5000 earthquakes were observed during about three-months observation period in each experiment. We conducted three-dimensional seismic tomography using manually picked P- and S-wave arrival time data. The obtained image shows a different seismic velocity structures in the mantle beneath the volcanic front between Izu and Bonin arcs. Low P-wave velocity anomalies in the mantle beneath the volcanic front in the Izu arc are limited at depths deeper than those in the Bonin arc. On the other hand, P-wave velocity in the low velocity anomalies beneath volcanic front in the Bonin arc is slower than that in the Izu arc. These large-scale along-arc structure variations in the mantle could relate to the geological and geophysical contrasts between Izu and Bonin arcs.

  14. NEAR-INFRARED VARIABILITY AMONG YOUNG STELLAR OBJECTS IN THE STAR FORMATION REGION CYGNUS OB7

    Energy Technology Data Exchange (ETDEWEB)

    Wolk, Scott J.; Rice, Thomas S. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Aspin, Colin [Institute for Astronomy, University of Hawaii at Manoa, 640 North Aohoku Place, Hilo, HI 96720 (United States)

    2013-08-20

    We present an analysis of near-infrared time-series photometry in J, H, and K bands for about 100 epochs of a 1 Degree-Sign Multiplication-Sign 1 Degree-Sign region of the Lynds 1003/1004 dark cloud in the Cygnus OB7 region. Augmented by data from the Wide-field Infrared Survey Explorer, we identify 96 candidate disk bearing young stellar objects (YSOs) in the region. Of these, 30 are clearly Class I or earlier. Using the Wide-Field Imaging Camera on the United Kingdom Infrared Telescope, we were able to obtain photometry over three observing seasons, with photometric uncertainty better than 0.05 mag down to J Almost-Equal-To 17. We study detailed light curves and color trajectories of {approx}50 of the YSOs in the monitored field. We investigate the variability and periodicity of the YSOs and find the data are consistent with all YSOs being variable in these wavelengths on timescales of a few years. We divide the variability into four observational classes: (1) stars with periodic variability stable over long timescales, (2) variables which exhibit short-lived cyclic behavior, (3) long-duration variables, and (4) stochastic variables. Some YSO variability defies simple classification. We can explain much of the observed variability as being due to dynamic and rotational changes in the disk, including an asymmetric or changing blocking fraction, changes to the inner disk hole size, as well as changes to the accretion rate. Overall, we find that the Class I:Class II ratio of the cluster is consistent with an age of <1 Myr, with at least one individual, wildly varying source {approx}100, 000 yr old. We have also discovered a Class II eclipsing binary system with a period of 17.87 days.

  15. FITspec: A New Algorithm for the Automated Fit of Synthetic Stellar Spectra for OB Stars

    Science.gov (United States)

    Fierro-Santillán, Celia R.; Zsargó, Janos; Klapp, Jaime; Díaz-Azuara, Santiago A.; Arrieta, Anabel; Arias, Lorena; Sigalotti, Leonardo Di G.

    2018-06-01

    In this paper we describe the FITspec code, a data mining tool for the automatic fitting of synthetic stellar spectra. The program uses a database of 27,000 CMFGEN models of stellar atmospheres arranged in a six-dimensional (6D) space, where each dimension corresponds to one model parameter. From these models a library of 2,835,000 synthetic spectra were generated covering the ultraviolet, optical, and infrared regions of the electromagnetic spectrum. Using FITspec we adjust the effective temperature and the surface gravity. From the 6D array we also get the luminosity, the metallicity, and three parameters for the stellar wind: the terminal velocity ({v}∞ ), the β exponent of the velocity law, and the clumping filling factor (F cl). Finally, the projected rotational velocity (v\\cdot \\sin i) can be obtained from the library of stellar spectra. Validation of the algorithm was performed by analyzing the spectra of a sample of eight O-type stars taken from the IACOB spectroscopic survey of Northern Galactic OB stars. The spectral lines used for the adjustment of the analyzed stars are reproduced with good accuracy. In particular, the effective temperatures calculated with the FITspec are in good agreement with those derived from spectral type and other calibrations for the same stars. The stellar luminosities and projected rotational velocities are also in good agreement with previous quantitative spectroscopic analyses in the literature. An important advantage of FITspec over traditional codes is that the time required for spectral analyses is reduced from months to a few hours.

  16. Preparedness of Ob/Gyn residents for fellowship training in gynecologic oncology

    Directory of Open Access Journals (Sweden)

    David W. Doo

    2015-04-01

    Full Text Available Residency training in obstetrics and gynecology is being challenged by increasingly stringent regulations and decreased operative experience. We sought to determine the perception of preparedness of incoming gynecologic oncology fellows for advanced surgical training in gynecologic oncology. An online survey was sent to gynecologic oncologists involved in fellowship training in the United States. They were asked to evaluate their most recent incoming clinical fellows in the domains of professionalism, level of independence/graduated responsibility, psychomotor ability, clinical evaluation and management, and academia and scholarship using a standard Likert-style scale. The response rate among attending physicians was 40% (n = 105/260 and 61% (n = 28/46 for program directors. Of those who participated, 49% reported that their incoming fellows could not independently perform a hysterectomy, 59% reported that they could not independently perform 30 min of a major procedure, 40% reported that they could not control bleeding, 40% reported that they could not recognize anatomy and tissue planes, and 58% reported that they could not dissect tissue planes. Fellows lacked an understanding of pathophysiology, treatment recommendations, and the ability to identify and treat critically ill patients. In the academic domain, respondents agreed that fellows were deficient in the areas of protocol design (54%, statistical analysis (54%, and manuscript writing (65%. These results suggest that general Ob/Gyn residency is ineffective in preparing fellows for advanced training in gynecologic oncology and should prompt a revision of the goals and objectives of resident education to correct these deficiencies.

  17. Identificarea izolatului bacterian P5 obţinut din plante de măr

    Directory of Open Access Journals (Sweden)

    MAGHER Maria

    2016-06-01

    Full Text Available The phytopathogen Erwinia amylovora (Burrill Winslow et al. is a bacterium having a major impact on pome fruit species causing identification problems at some development phenophases of trees. The aim of this paper was to identify the bacterial isolate P5 obtained from apple tree samples using classical and modern methods recommended for the bacterium E. amylovora (API 20E test, gas chromatography, PCR, DASELISA and indirect immunofluorescence. As a result of our investigations, the bacterium Erwinia amylovora was clearly identified. Taking into consideration the quarantine status of the phytopathogen E. amylovora, it is necessary to carry out the phytosanitary test sin order to monitor the presence of fire blight on pome fruit species as well as to implement timely the required preventive and curative control measures. Rezumat. Fitopatogenul Erwinia amylovora (Burrill Winslow et al. este o bacterie cu un impact deosebit asupra speciilor pomicole sămânţoase, care prezintă probleme de identificare la anumite fenofaze de dezvoltare a pomilor. Scopul acestei lucrări a fost de a identifica izolatul bacterian P5, obţinut din probe de măr, prin metode clasice şi contemporane recomandate pentru bacteria E. amylovora (testul API 20E, gaz-cromatografie, PCR, DAS-ELISA, imunofluorescenţă indirectă. În rezultatul cercetărilor a fost identificată bacteria Erwinia amylovora. Având în vedere statutul de carantină al fitopatogenului E. amylovora, se impune necesitatea efectuării obligatorii a sondajelor fitosanitare pentru monitorizarea prezenţei focului bacterian la culturile pomicole sămânţoase şi efectuarea la timp a măsurilor preventive şi curative de combatere.

  18. Expressão do gene da leptina e seu receptor Ob-Rb no parênquima mamário de novilhas leiteiras Leptin and leptin receptor Ob-Rb gene expression in mammary parenchyma of dairy heifers

    Directory of Open Access Journals (Sweden)

    Betina Joyce Lew

    2012-05-01

    Full Text Available Objetivou-se com este trabalho avaliar os efeitos de uma dieta de alto nível de energia e proteína combinada com a aplicação de bST no perfil de expressão dos genes da leptina e de seu receptor Ob-Rb no parênquima mamário de novilhas leiteiras. Foram utilizadas amostras de parênquima mamário de 32 novilhas holandesas distribuídas aleatoriamente em quatro tratamentos (n=8: dieta com alto ou baixo teor de energia e proteína combinada ou não com a aplicação de bST. O delineamento utilizado foi em blocos casualizados com arranjo de tratamentos em esquema fatorial 2 × 2. A extração do RNA total das amostras de tecido foi feita e o nível de expressão gênica foi analisado por qRT-PCR utilizando-se o gene da glicuronidase β como controle, pelo método 2-ΔΔCt. Animais que receberam a dieta com alto conteúdo de energia e proteína apresentaram maior expressão de mRNA de leptina, com aumento de 56%, e menor expressão de mRNA do receptor Ob-Rb, com redução de 18%. Por outro lado, a aplicação de bST resultou em diminuição da expressão do mRNA de leptina e do receptor Ob-Rb em 74% e 23%, respectivamente. Não houve interação entre dieta e aplicação de bST. O aumento na expressão de leptina pode explicar, ao menos em parte, os efeitos negativos da dieta de alta energia e proteína, oferecida no período pré-púbere, sobre a produção de leite de novilhas leiteiras.The objective of this study was to examine the effects of a diet with high level of energy and protein, combined with bST injections, on leptin and leptin-receptor (Ob-Rb gene expression profile in the mammary parenchyma of dairy heifers. Mammary parenchyma samples from 32 Holstein heifers, randomly assigned to one of four treatments (n=8, were utilized: high or low energy and protein diet, with or without bST injection. The experiment was designed in randomized blocks and arranged in a 2 × 2 factorial arrangement. Total RNA was extracted from tissue samples

  19. Increasing the number and signal-to-noise ratio of OBS traces with supervirtual refraction interferometry and free-surface multiples

    KAUST Repository

    Bharadwaj, P.; Wang, X.; Schuster, Gerard T.; McIntosh, K.

    2013-01-01

    The theory of supervirtual interferometry is modified so that free-surface related multiple refractions can be used to enhance the signal-to-noise ratio (SNR) of primary refraction events by a factor proportional to√Ns, where Ns is the number of post-critical sources for a specified refraction multiple. We also show that refraction multiples can be transformed into primary refraction events recorded at virtual hydrophones located between the actual hydrophones. Thus, data recorded by a coarse sampling of ocean bottom seismic (OBS) stations can be transformed, in principle, into a virtual survey with P times more OBS stations, where P is the order of the visible free-surface related multiple refractions. The key assumption is that the refraction arrivals are those of head waves, not pure diving waves. The effectiveness of this method is validated with both synthetic OBS data and an OBS data set recorded offshore from Taiwan. Results show the successful reconstruction of far-offset traces out to a source-receiver offset of 120 km. The primary supervirtual traces increase the number of pickable first arrivals from approximately 1600 to more than 3100 for a subset of the OBS data set where the source is only on one side of the recording stations. In addition, the head waves associated with the first-order free-surface refraction multiples allow for the creation of six new common receiver gathers recorded at virtual OBS station located about half way between the actual OBS stations. This doubles the number of OBS stations compared to the original survey and increases the total number of pickable traces from approximately 1600 to more than 6200. In summary, our results with the OBS data demonstrate that refraction interferometry can sometimes more than quadruple the number of usable traces, increase the source-receiver offsets, fill in the receiver line with a denser distribution of OBS stations, and provide more reliable picking of first arrivals. Apotential liability

  20. Increasing the number and signal-to-noise ratio of OBS traces with supervirtual refraction interferometry and free-surface multiples

    KAUST Repository

    Bharadwaj, P.

    2013-01-10

    The theory of supervirtual interferometry is modified so that free-surface related multiple refractions can be used to enhance the signal-to-noise ratio (SNR) of primary refraction events by a factor proportional to√Ns, where Ns is the number of post-critical sources for a specified refraction multiple. We also show that refraction multiples can be transformed into primary refraction events recorded at virtual hydrophones located between the actual hydrophones. Thus, data recorded by a coarse sampling of ocean bottom seismic (OBS) stations can be transformed, in principle, into a virtual survey with P times more OBS stations, where P is the order of the visible free-surface related multiple refractions. The key assumption is that the refraction arrivals are those of head waves, not pure diving waves. The effectiveness of this method is validated with both synthetic OBS data and an OBS data set recorded offshore from Taiwan. Results show the successful reconstruction of far-offset traces out to a source-receiver offset of 120 km. The primary supervirtual traces increase the number of pickable first arrivals from approximately 1600 to more than 3100 for a subset of the OBS data set where the source is only on one side of the recording stations. In addition, the head waves associated with the first-order free-surface refraction multiples allow for the creation of six new common receiver gathers recorded at virtual OBS station located about half way between the actual OBS stations. This doubles the number of OBS stations compared to the original survey and increases the total number of pickable traces from approximately 1600 to more than 6200. In summary, our results with the OBS data demonstrate that refraction interferometry can sometimes more than quadruple the number of usable traces, increase the source-receiver offsets, fill in the receiver line with a denser distribution of OBS stations, and provide more reliable picking of first arrivals. Apotential liability

  1. Breakup Style and Magmatic Underplating West of the Lofoten Islands, Norway, Based on OBS Data.

    Science.gov (United States)

    Breivik, A. J.; Faleide, J. I.; Mjelde, R.; Murai, Y.; Flueh, E. R.

    2014-12-01

    The breakup of the Northeast Atlantic in the Early Eocene was magma-rich, forming the major part of the North Atlantic Igneous Province (NAIP). This is seen as extrusive and intrusive magmatism in the continental domain, and as a thicker than normal oceanic crust produced the first few million years after continental breakup. The maximum magma productivity and the duration of excess magmatism varies along the margins of Northwest Europe and East Greenland, to some extent as a function of the distance from the Iceland hotspot. The Vøring Plateau off mid-Norway is the northernmost of the margin segments in northwestern Europe with extensive magmatism. North of the plateau, magmatism dies off towards the Lofoten Margin, marking the northern boundary of the NAIP here. In 2003, as part of the Euromargins Program we collected an Ocean Bottom Seismometer (OBS) profile from mainland Norway, across the Lofoten Islands, and out into the deep ocean. Forward velocity modeling using raytracing reveals a continental margin that shows transitional features between magma-rich and magma-poor rifting. On one hand, we detect an up to 2 km thick and 40-50 km wide magmatic underplate of the outer continent, on the other hand, continental thinning is greater and intrusive magmatism less than farther south. Continental breakup also appears to be somewhat delayed compared to breakup on the Vøring Plateau, consistent with increased extension. This indicates that magmatic diking, believed to quickly lead to continental breakup of volcanic margins and thus to reduce continental thinning, played a much lesser role here than at the plateau. Early post-breakup oceanic crust is up to 8 km thick, less than half of that observed farther south. The most likely interpretation of these observations, is that the source for the excess magmatism of the NAIP was not present at the Lofoten Margin during rifting, and that the excess magmatism actually observed was the result of lateral transport from the

  2. NEAR-INFRARED VARIABILITY IN YOUNG STARS IN CYGNUS OB7

    Energy Technology Data Exchange (ETDEWEB)

    Rice, Thomas S. [Department of Astronomy, Harvard University, 60 Garden Street, Cambridge, MA 02138 (United States); Wolk, Scott J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Aspin, Colin [Institute for Astronomy, University of Hawaii at Manoa, 640 N Aohoku Pl, Hilo, HI 96720 (United States)

    2012-08-10

    We present the first results from a 124 night J, H, K near-infrared monitoring campaign of the dark cloud L 1003 in Cygnus OB7, an active star-forming region. Using three seasons of UKIRT observations spanning 1.5 years, we obtained high-quality photometry on 9200 stars down to J = 17 mag, with photometric uncertainty better than 0.04 mag. On the basis of near-infrared excesses from disks, we identify 30 pre-main-sequence stars, including 24 which are newly discovered. We analyze those stars and find that the NIR excesses are significantly variable. All 9200 stars were monitored for photometric variability; among the field star population, {approx}160 exhibited near-infrared variability (1.7% of the sample). Of the 30 young stellar objects (YSOs), 28 of them (93%) are variable at a significant level. Of the 30 YSOs, twenty-five have near-infrared excess consistent with simple disk-plus-star classical T Tauri models. Nine of these (36%) drift in color space over the course of these observations and/or since Two Micron All Sky Survey observations such that they cross the boundary defining the NIR excess criteria; effectively, they have a transient near-infrared excess. Thus, time-series JHK observations can be used to obtain a more complete sample of disk-bearing stars than single-epoch JHK observations. About half of the YSOs have color-space variations parallel to either the classical T Tauri star locus or a hybrid track which includes the dust reddening trajectory. This indicates that the NIR variability in YSOs that possess accretion disks arises from a combination of variable extinction and changes in the inner accretion disk: either in accretion rate, central hole size, and/or the inclination of the inner disk. While some variability may be due to stellar rotation, the level of variability on the individual stars can exceed a magnitude. This is a strong empirical suggestion that protoplanetary disks are quite dynamic and exhibit more complex activity on short

  3. HD 144548: A young triply eclipsing system in the Upper Scorpius OB association

    Science.gov (United States)

    Alonso, R.; Deeg, H. J.; Hoyer, S.; Lodieu, N.; Palle, E.; Sanchis-Ojeda, R.

    2015-12-01

    The star HD 144548 (=HIP 78977; TYP 6212-1273-1) has been known as a detached eclipsing binary and a bona-fide member of the Upper Scorpius OB association. Continuous photometry from the K2 mission on Campaign Two has revealed the presence of additional eclipses due to the presence of a third star in the system. These are explained by a system composed of the two previously known members of the eclipsing system (Ba and Bb) with a period of 1.63 d, orbiting around an F7-F8V star with a period of 33.945 ± 0.002 d in an eccentric orbit (eA = 0.2652 ± 0.0003). The timing of the eclipses of Ba and Bb reveals the same 33.9 d periodicity, which we interpret as the combination of a light time effect combined with dynamical perturbations on the close system. Here we combine radial velocities and analytical approximations for the timing of the eclipses to derive masses and radii for the three components of the system. We obtain a mass of 1.44 ± 0.04 M⊙ and radius of 2.41 ± 0.03 R⊙ for the A component, and almost identical masses and radii of about 0.96 M⊙ and 1.33 R⊙ for each of the two components of the close binary. HD 144548 is the first triply eclipsing system for which radial velocities of all components could be measured. Partially based on observations made with the Italian Telescopio Nazionale Galileo (TNG) operated by the Fundación Galileo Galilei of the INAF, the Nordic Optical Telescope, operated by the Nordic Optical Telescope Scientific Association, and the William Herschel Telescope (programme DDT58 - PI Lodieu) operated by the Isaac Newton Group on the island of La Palma at the Spanish Observatorio Roque de los Muchachos of the IAC. This paper includes data collected by the Kepler mission. Funding for the Kepler mission is provided by the NASA Science Mission directorate.Appendices are available in electronic form at http://www.aanda.org

  4. SPITZER SPECTROSCOPY OF CIRCUMSTELLAR DISKS IN THE 5 Myr OLD UPPER SCORPIUS OB ASSOCIATION

    International Nuclear Information System (INIS)

    Dahm, S. E.; Carpenter, John M.

    2009-01-01

    We present mid-infrared spectra between 5.2 and 38 μm for 26 disk-bearing members of the ∼5 Myr old Upper Scorpius OB association obtained with the Infrared Spectrograph (IRS) onboard the Spitzer Space Telescope. We find clear evidence for changes in the spectral characteristics of dust emission between the early-type (B+A) and late-type (K+M) infrared excess stars. The early-type members exhibit featureless continuum excesses that become apparent redward of ∼8 μm. In contrast, 10 and 20 μm silicate features or polycyclic aromatic hydrocarbon emission are present in all but one of the late-type excess members of Upper Scorpius. The strength of silicate emission among late-type Upper Scorpius members is spectral-type dependent, with the most prominent features being associated with K5-M2-type stars. By fitting the spectral energy distributions (SED) of a representative sample of low-mass stars with accretion disk models, we find that the SEDs are consistent with models having inner disk radii ranging from ∼0.2 to 1.2 AU. Complementary high-resolution (R ∼ 33, 000) optical (λλ4800-9200) spectra for the Upper Scorpius excess stars were examined for signatures of gaseous accretion. Of the 35 infrared excess stars identified in Upper Scorpius, only seven (all late-type) exhibit definitive signatures of accretion. Mass-accretion rates for these stars were estimated to range from 10 -11 to 10 -8.9 M sun yr -1 . Compared to Class II sources in Taurus-Auriga, the disk population in Upper Scorpius exhibits reduced levels of near- and mid-infrared excess emission and an order of magnitude lower mass-accretion rates. These results suggest that the disk structure has changed significantly over the 2-4 Myr in age separating these two stellar populations. The ubiquity of depleted inner disks in the Upper Scorpius excess sample implies that such disks are a common evolutionary pathway that persists for some time.

  5. OB/GYN boot cAMP using high-fidelity human simulators: enhancing residents' perceived competency, confidence in taking a leadership role, and stress hardiness.

    Science.gov (United States)

    Pliego, Jose F; Wehbe-Janek, Hania; Rajab, M Hasan; Browning, Jeff L; Fothergill, Russell E

    2008-01-01

    To evaluate the effectiveness of an obstetrical and gynecologic (Ob/Gyn) Boot Camp simulation training on perceived technical competency, confidence in a leadership role, and stress hardiness of resident training. We conducted a prospective pilot study on the effectiveness of an Ob/Gyn Boot Camp on resident training. Residents participated in an intensive immersion in clinical simulation of common obstetrical emergencies including shoulder dystocia, neonatal resuscitation, postpartum hemorrhage, and ruptured ectopic pregnancy. After the training, residents completed a Web-based survey on their perceptions of how the Ob/Gyn Boot Camp affected their 1) technical competency in the assessment and management of their patients, 2) confidence in taking a leadership role, and 3) stress hardiness. Residents rated their perceptions on a Likert scale of 1 to 5, 1 = poor to 5 = excellent. Twenty-three (14 Ob/Gyn and 9 family medicine) residents participated in this pilot study. Eighteen (78%) residents completed the online survey; 4 Ob/Gyn and 1 family medicine resident did not complete the survey. The residents reported that the simulation training stimulated an interest in learning key skills for obstetrical and gynecologic emergencies. Ob/Gyn residents reported significant improvement in their perceived technical competence and stress hardiness after the Boot Camp. However both Ob/Gyn and family medicine residents reported no significant improvement of confidence in their leadership abilities during obstetrical emergencies after the Boot Camp. Boot Camp simulation training early in the curriculum has the potential for enhancing residents' self-assessments of confidence, competency, and stress hardiness in managing obstetrical emergencies.

  6. Molecular Gas toward the Gemini OB1 Molecular Cloud Complex. II. CO Outflow Candidates with Possible WISE Associations

    Science.gov (United States)

    Li, Yingjie; Li, Fa-Cheng; Xu, Ye; Wang, Chen; Du, Xin-Yu; Yang, Wenjin; Yang, Ji

    2018-03-01

    We present a large-scale survey of CO outflows in the Gem OB1 molecular cloud complex and its surroundings, using the Purple Mountain Observatory Delingha 13.7 m telescope. A total of 198 outflow candidates were identified over a large area (∼58.5 square degrees), of which 193 are newly detected. Approximately 68% (134/198) are associated with the Gem OB1 molecular cloud complex, including clouds GGMC 1, GGMC 2, BFS 52, GGMC 3, and GGMC 4. Other regions studied are: the Local arm (Local Lynds, West Front), Swallow, Horn, and Remote cloud. Outflow candidates in GGMC 1, BFS 52, and Swallow are mainly located at ring-like or filamentary structures. To avoid excessive uncertainty in distant regions (≳3.8 kpc), we only estimated the physical parameters for clouds in the Gem OB1 molecular cloud complex and in the Local arm. In those clouds, the total kinetic energy and the energy injection rate of the identified outflow candidates are ≲1% and ≲3% of the turbulent energy and the turbulent dissipation rate of each cloud, indicating that the identified outflow candidates cannot provide enough energy to balance turbulence of their host cloud at the scale of the entire cloud (several to dozens of parsecs). The gravitational binding energy of each cloud is ≳135 times the total kinetic energy of the identified outflow candidates within the corresponding cloud, indicating that the identified outflow candidates cannot cause major disruptions to the integrity of their host cloud at the scale of the entire cloud.

  7. THE MASSIVE STAR-FORMING REGION CYGNUS OB2. II. INTEGRATED STELLAR PROPERTIES AND THE STAR FORMATION HISTORY

    International Nuclear Information System (INIS)

    Wright, N. J.; Drake, J. J.; Drew, J. E.; Vink, J. S.

    2010-01-01

    Cygnus OB2 is the nearest example of a massive star-forming region (SFR), containing over 50 O-type stars and hundreds of B-type stars. We have analyzed the properties of young stars in two fields in Cyg OB2 using the recently published deep catalog of Chandra X-ray point sources with complementary optical and near-IR photometry. Our sample is complete to ∼1 M sun (excluding A- and B-type stars that do not emit X-rays), making this the deepest study of the stellar properties and star formation history in Cyg OB2 to date. From Siess et al. isochrone fits to the near-IR color-magnitude diagram, we derive ages of 3.5 +0.75 -1.0 and 5.25 +1.5 -1.0 Myr for sources in the two fields, both with considerable spreads around the pre-main-sequence isochrones. The presence of a stellar population somewhat older than the present-day O-type stars, also fits in with the low fraction of sources with inner circumstellar disks (as traced by the K-band excess) that we find to be very low, but appropriate for a population of age ∼5 Myr. We also find that the region lacks a population of highly embedded sources that is often observed in young SFRs, suggesting star formation in the vicinity has declined. We measure the stellar mass functions (MFs) in this limit and find a power-law slope of Γ = -1.09 ± 0.13, in good agreement with the global mean value estimated by Kroupa. A steepening of the slope at higher masses is observed and suggested as due to the presence of the previous generation of stars that have lost their most massive members. Finally, combining our MF and an estimate of the radial density profile of the association suggests a total mass of Cyg OB2 of ∼3 x 10 4 M sun , similar to that of many of our Galaxy's most massive SFRs.

  8. Search for OB stars running away from young star clusters. II. The NGC 6357 star-forming region

    Science.gov (United States)

    Gvaramadze, V. V.; Kniazev, A. Y.; Kroupa, P.; Oh, S.

    2011-11-01

    Dynamical few-body encounters in the dense cores of young massive star clusters are responsible for the loss of a significant fraction of their massive stellar content. Some of the escaping (runaway) stars move through the ambient medium supersonically and can be revealed via detection of their bow shocks (visible in the infrared, optical or radio). In this paper, which is the second of a series of papers devoted to the search for OB stars running away from young ( ≲ several Myr) Galactic clusters and OB associations, we present the results of the search for bow shocks around the star-forming region NGC 6357. Using the archival data of the Midcourse Space Experiment (MSX) satellite and the Spitzer Space Telescope, and the preliminary data release of the Wide-Field Infrared Survey Explorer (WISE), we discovered seven bow shocks, whose geometry is consistent with the possibility that they are generated by stars expelled from the young (~1-2 Myr) star clusters, Pismis 24 and AH03 J1725-34.4, associated with NGC 6357. Two of the seven bow shocks are driven by the already known OB stars, HD 319881 and [N78] 34. Follow-up spectroscopy of three other bow-shock-producing stars showed that they are massive (O-type) stars as well, while the 2MASS photometry of the remaining two stars suggests that they could be B0 V stars, provided that both are located at the same distance as NGC 6357. Detection of numerous massive stars ejected from the very young clusters is consistent with the theoretical expectation that star clusters can effectively lose massive stars at the very beginning of their dynamical evolution (long before the second mechanism for production of runaway stars, based on a supernova explosion in a massive tight binary system, begins to operate) and lends strong support to the idea that probably all field OB stars have been dynamically ejected from their birth clusters. A by-product of our search for bow shocks around NGC 6357 is the detection of three circular

  9. Spodbujanje ustvarjalnosti v poletnih počitniških varstvih, sofinanciranih s strani Mestne občine Ljubljana

    OpenAIRE

    Grm, Urša

    2017-01-01

    Spodbujanje ustvarjalnosti skozi umetnost ima ključni pomen pri snovanju novih in različnih idej, izražanju domišljije, kakovostnem preživljanju časa ter izboljšanju kakovosti življenja (Knoll, 2011). Aktivira otrokove intelektualne, čustvene in motivacijske procese (Kroflič in Gobec, 1995). H kakovostnemu preživljanju časa poletnih počitnic prispeva Mestna občina Ljubljana (MOL), ki sofinancira prostočasne in preventivne programe za otroke od 1.–5. razreda osnovne šole s stalnim prebivališče...

  10. More accurate definition of liquation dome in Na2O-B2O3-SiO2 system

    International Nuclear Information System (INIS)

    Alekseeva, Z.D.; Mazurin, O.V.; Aver'yanov, V.I.; Galakhov, F.Ya.

    1977-01-01

    The liquation region in the system Na 2 O-B 2 O 3 -SiO 2 was investigated. The liquation temperatures were determined by the boundary of disappearance of opalescence in specimens with pre-induced opalescence. Extrapolation of the concentration dependences of the liquation temperature along sections with a constant SiO 2 content to a point indicates that with a SiO 2 content of 20-40% the liquation boundary in the system B 2 O 3 -SiO 2 hardly lies above 450 deg C

  11. Globules and pillars in Cygnus X. I. Herschel far-infrared imaging of the Cygnus OB2 environment

    Science.gov (United States)

    Schneider, N.; Bontemps, S.; Motte, F.; Blazere, A.; André, Ph.; Anderson, L. D.; Arzoumanian, D.; Comerón, F.; Didelon, P.; Di Francesco, J.; Duarte-Cabral, A.; Guarcello, M. G.; Hennemann, M.; Hill, T.; Könyves, V.; Marston, A.; Minier, V.; Rygl, K. L. J.; Röllig, M.; Roy, A.; Spinoglio, L.; Tremblin, P.; White, G. J.; Wright, N. J.

    2016-06-01

    The radiative feedback of massive stars on molecular clouds creates pillars, globules and other features at the interface between the H II region and molecular cloud. Optical and near-infrared observations from the ground as well as with the Hubble or Spitzer satellites have revealed numerous examples of such cloud structures. We present here Herschel far-infrared observations between 70 μm and 500 μm of the immediate environment of the rich Cygnus OB2 association, performed within the Herschel imaging survey of OB Young Stellar objects (HOBYS) program. All of the observed irradiated structures were detected based on their appearance at 70 μm, and have been classified as pillars, globules, evaporating gasous globules (EGGs), proplyd-like objects, and condensations. From the 70 μm and 160 μm flux maps, we derive the local far-ultraviolet (FUV) field on the photon dominated surfaces. In parallel, we use a census of the O-stars to estimate the overall FUV-field, that is 103-104 G0 (Habing field) close to the central OB cluster (within 10 pc) and decreases down to a few tens G0, in a distance of 50 pc. From a spectral energy distribution (SED) fit to the four longest Herschel wavelengths, we determine column density and temperature maps and derive masses, volume densities and surface densities for these structures. We find that the morphological classification corresponds to distinct physical properties. Pillars and globules are massive (~500 M⊙) and large (equivalent radius r ~ 0.6 pc) structures, corresponding to what is defined as "clumps" for molecular clouds. EGGs and proplyd-likeobjects are smaller (r ~ 0.1 and 0.2 pc) and less massive (~10 and ~30 M⊙). Cloud condensations are small (~0.1 pc), have an average mass of 35 M⊙, are dense (~6 × 104 cm-3), and can thus be described as molecular cloud "cores". All pillars and globules are oriented toward the Cyg OB2 association center and have the longest estimated photoevaporation lifetimes, a few million

  12. Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice

    Directory of Open Access Journals (Sweden)

    Peter E. M. Gibbs

    2016-01-01

    Full Text Available Insulin’s stimulation of glucose uptake by binding to the IRK extracellular domain is compromised in diabetes. We have recently described an unprecedented approach to stimulating glucose uptake. KYCCSRK (P2 peptide, corresponding to the C-terminal segment of hBVR, was effective in binding to and inducing conformational change in the IRK intracellular kinase domain. Although myristoylated P2, made of L-amino acids, was effective in cell culture, its use for animal studies was unsuitable. We developed a peptidase-resistant formulation of the peptide that was efficient in both mice and cell culture systems. The peptide was constructed of D-amino acids, in reverse order, and blocked at both termini. Delivery of the encapsulated peptide to HepG2 and HSKM cells was confirmed by its prolonged effect on stimulation of glucose uptake (>6 h. The peptide improved glucose clearance in both wild-type and Ob/Ob mice; it lowered blood glucose levels and suppressed glucose-stimulated insulin secretion. IRK activity was stimulated in the liver of treated mice and in cultured cells. The peptide potentiated function of IRK’s downstream effector, Akt-GSK3-(α,β axis. Thus, P2-based approach can be used for improving glucose uptake by cells. Also, it allows for screening peptides in vitro and in animal models for treatment of diabetes.

  13. The CIDA-QUEST large-scale survey of Orion OB1: evidence for rapid disk dissipation in a dispersed stellar population.

    Science.gov (United States)

    Briceño, C; Vivas, A K; Calvet, N; Hartmann, L; Pacheco, R; Herrera, D; Romero, L; Berlind, P; Sánchez, G; Snyder, J A; Andrews, P

    2001-01-05

    We are conducting a large-scale, multiepoch, optical photometric survey [Centro de Investigaciones de Astronomia-Quasar Equatorial Survey Team (CIDA-QUEST)] covering about 120 square degrees to identify the young low-mass stars in the Orion OB1 association. We present results for an area of 34 square degrees. Using photometric variability as our main selection criterion, as well as follow-up spectroscopy, we confirmed 168 previously unidentified pre-main sequence stars that are about 0.6 to 0.9 times the mass of the sun (Mo), with ages of about 1 million to 3 million years (Ori OB1b) and about 3 million to 10 million years (Ori OB1a). The low-mass stars are spatially coincident with the high-mass (at least 3 Mo) members of the associations. Indicators of disk accretion such as Halpha emission and near-infrared emission from dusty disks fall sharply from Ori OB1b to Ori OB1a, indicating that the time scale for disk dissipation and possibly the onset of planet formation is a few million years.

  14. Sensitivity analysis of P-waves and S-waves to gas hydrate in the Shenhu area using OBS

    Science.gov (United States)

    Xing, Lei; Liu, Xueqin; Zhang, Jin; Liu, Huaishan; Zhang, Jing; Li, Zizheng; Wang, Jianhua

    2018-02-01

    Compared to towed streamers, ocean-bottom seismometers (OBS) obtain both S-wave data and richer wavefield information. In this paper, the induced polarization method is used to conduct wavefield separation on OBS data obtained from the Shenhu area in the South China Sea. A comparison of the changes in P- and S-waves, and a comprehensive analysis of geological factors within the area, enable analysis and description of the occurrence of natural gas hydrate in the study area. Results show an increase in P-wave velocity when natural gas hydrate exists in the formation, whereas the S-wave velocity remains almost constant, as S-waves can only propagate through the rock skeleton. Therefore, the bottom-simulating reflection (BSR) response of the P-wave is better than that of the S-wave in the frequency analysis profile. In a wide-angle section, the refractive wave of the hydrate layer is evident when using P-wave components but identification is difficult with S-wave components. This velocity model illustrates the sensitivity of P- and S-wave components to gas hydrate. The use of this polarization method and results of analysis provide technical and theoretical support for research on hydrate deposits and other geological features in the Shenhu area.

  15. THE NON-THERMAL, TIME-VARIABLE RADIO EMISSION FROM Cyg OB2 no. 5: A WIND-COLLISION REGION

    International Nuclear Information System (INIS)

    Ortiz-Leon, Gisela N.; Loinard, Laurent; RodrIguez, Luis F.; Dzib, Sergio A.; Mioduszewski, Amy J.

    2011-01-01

    The radio emission from the well-studied massive stellar system Cyg OB2 no. 5 is known to fluctuate with a period of 6.7 years between a low-flux state, when the emission is entirely of free-free origin, and a high-flux state, when an additional non-thermal component (of hitherto unknown nature) appears. In this paper, we demonstrate that the radio flux of that non-thermal component is steady on timescales of hours and that its morphology is arc-like. This shows that the non-thermal emission results from the collision between the strong wind driven by the known contact binary in the system and that of an unseen companion on a somewhat eccentric orbit with a 6.7 year period and a 5-10 mas semimajor axis. Together with the previously reported wind-collision region located about 0.''8 to the northeast of the contact binary, so far Cyg OB2 no. 5 appears to be the only multiple system known to harbor two radio-imaged wind-collision regions.

  16. Paraffin oil as a "methane vector" for rapid and high cell density cultivation of Methylosinus trichosporium OB3b.

    Science.gov (United States)

    Han, Bing; Su, Tao; Wu, Hao; Gou, Zhongxuan; Xing, Xin-Hui; Jiang, Hao; Chen, Yin; Li, Xin; Murrell, J Colin

    2009-06-01

    Slow growth and relatively low cell densities of methanotrophs have limited their uses in industrial applications. In this study, a novel method for rapid cultivation of Methylosinus trichosporium OB3b was studied by adding a water-immiscible organic solvent in the medium. Paraffin oil was the most effective at enhancing cell growth and final cell density. This is at least partially due to the increase of methane gas transfer between gas and medium phases since methane solubility is higher in paraffin than in water/nitrate minimal salt medium. During cultivation with paraffin oil at 5% (v/v) in the medium, M. trichosporium OB3b cells also showed higher concentrations of the intermediary metabolites, such as formic acid and pyruvic acid, and consumed more methane compared with the control. Paraffin as methane vector to improve methanotroph growth was further studied in a 5-L fermentor at three concentrations (i.e., 2.5%, 5%, and 10%). Cell density reached about 14 g dry weight per liter with 5% paraffin, around seven times higher than that of the control (without paraffin). Cells cultivated with paraffin tended to accumulate around the interface between oil droplets and the water phase and could exist in oil phase in the case of 10% (v/v) paraffin. These results indicated that paraffin could enhance methanotroph growth, which is potentially useful in cultivation of methanotrophs in large scale in industry.

  17. Effects of copper mineralogy and methanobactin on cell growth and sMMO activity in Methylosinus trichosporium OB3b

    Directory of Open Access Journals (Sweden)

    C. Dennison

    2011-10-01

    Full Text Available Controls on in situ methanotroph activity are not well understood. One potentially important parameter is copper (Cu because it is the metal-centre of particulate methane monooxygenase (pMMO, the most active enzyme for oxidizing methane to methanol. Further, Cu-to-cell ratios influence the relative expression of pMMO versus the alternate soluble MMO (sMMO in some species. However, most methanotroph studies only have assessed readily soluble forms of Cu (e.g. CuCl2 and there is a dearth of Cu-related activity data for Cu sources more common in the environment. Here we quantified sMMO activity (as a practical indicator of Cu availability and growth kinetics in Methylosinus trichosporium OB3b, an organism that expresses both pMMO and sMMO, when grown on Cu-minerals with differing dissolution equilibria to assess how mineral type and methanobactin (mb might influence in situ methanotroph activity. Mb is a molecule produced by M. trichosporium OB3b that has a high affinity for Cu, reduces Cu toxicity, and may influence Cu availability in terrestrial systems. CuCO3.Cu(OH2 and CuO were chosen for study based on modelling data, reflecting more and less soluble minerals, respectively, and were found to affect M. trichosporium OB3b activity differently. Cells grew without growth lag and with active pMMO on CuCO3.Cu(OH2, regardless of the amount of mineral supplied (−1. The organism also grew well on CuO; however, significant sMMO activity was retained up to 50 μmoles Cu-total l−1, although sMMO activity was suppressed by supplemental mb and-or direct cell-mineral contact. Mb addition increased growth rates (p < 0.05 with both minerals. Results show mb broadly stimulates growth, but Cu mineralogy and mb dictate whether sMMO or pMMO is active in the cells. This explains why sMMO activity has been seen in soils with high Cu and also has implications for predicting dominant MMO activity in terrestrial bioremediation applications.

  18. Primary successions of vegetation on technogenic sand patches in oil and gas producing districts of the middle Ob' river basin

    Energy Technology Data Exchange (ETDEWEB)

    Shilova, I I

    1977-11-01

    Intensive economic exploitation of the natural resources of the oil-and-gas producing districts of the central Ob' basin has led to increased exposure of sandy patches over the landscape. These sandy areas are becoming a common site. Technogenic factors involved include, for example, construction projects, oil-drilling and the like. Exposure is accelerated by wind and water erosion. Efforts are underway to reintroduce verdure in the region, and a study has been underway of the features of the ecotope and the stages of natural overgrowth of the area of reclamation. This overgrowth is proceeding well. Vegetation is of the syngenetic succession type, involving four successive stages and formation of associations of a zonal character. Seventy-four species of yeast, 2 species of fungi, 2 of lichens, 19 of Bryophyton and 106 of vascular spore- and covered-seed plants of the area have been recorded, and are tabulated. Recultivation will require due attention to existing conditions. 14 references.

  19. Oczekiwania klienta pokolenia Y w zakresie sposobu obsługi i oferty biur podróży

    OpenAIRE

    Przybylska, Anna

    2015-01-01

    W pracy scharakteryzowano profil klienta w działalności biura podróży oraz rolę, jaką w niej odgrywa. Wskazano na znaczenie odpowiednich relacji z klientem, które wpływają na jego obsługę i zadowolenie. Krótko opisano zarządzanie relacjami z klientem oraz wytyczne do prawidłowego wprowadzenia tych zasad w firmie w celu maksymalizacji zysków. Badania zostały przeprowadzone na grupie konsumentów z przedziału wiekowego charakteryzującego pokolenie Y oraz pokolenie X – w celach ...

  20. Migration of global radioactive fallout to the Arctic Ocean (on the example of the Ob's river drainage basin).

    Science.gov (United States)

    Miroshnikov, A; Semenkov, I

    2012-11-01

    This article provides an assessment of the impact of global fallout on (137)Cs contamination in the bottom sediments of Kara Sea. The erosiveness of 10th-level river basins was estimated by landscape-geochemical and geomorphological characteristics. All 10th-level basins (n=154) were separated into three groups: mountain, mountain-lowland and plain. Four different types of basins were identified depending on the geochemical conditions of the migration of radiocaesium in the plain and mountain-lowland. Classifications of types were carried out using the geographic information systems-based approach. The Ob River's macroarena covers 3.5 million km(2). Internal drainage basins cover 23 % of the macroarena and accumulate whole radiocaesium from the global fallout. The remaining territory is transitional for the (137)Cs. The field research works performed in the three plain first-level basins allow one to estimate the radiocaesium run-off. The calculations show that 7 % of (137)Cs was removed from the first-level basin in arable land. Accumulation of radiocaesium in the first-level basin under undisturbed forest is 99.8 %. The research shows that (137)Cs transfer from the humid basins is in the range of 6.9-25.5 TBq and for semi-humid basins 5.6-285.5 TBq. The areas of these basins cover 40 and 8 % of the Ob River's macroarena, respectively. Drainage lakes and reservoir drainage basins make up 22 % of the macroarena. Mountainous and semi-arid drainage basins cover 7 % of the macroarena.

  1. TOWARD COMPLETE STATISTICS OF MASSIVE BINARY STARS: PENULTIMATE RESULTS FROM THE CYGNUS OB2 RADIAL VELOCITY SURVEY

    Energy Technology Data Exchange (ETDEWEB)

    Kobulnicky, Henry A.; Lundquist, Michael J.; Burke, Jamison; Chapman, James; Keller, Erica; Lester, Kathryn; Rolen, Emily K.; Topel, Eric; Bhattacharjee, Anirban; Smullen, Rachel A.; Álvarez, Carlos A. Vargas; Runnoe, Jessie C.; Dale, Daniel A.; Brotherton, Michael M. [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82070 (United States); Kiminki, Daniel C., E-mail: chipk@uwyo.edu, E-mail: jburke2@swarthmore.edu, E-mail: jc6380@mcla.edu, E-mail: kelle22e@mtholyoke.edu, E-mail: kvl214@lehigh.edu, E-mail: emily.k.rolen@vanderbilt.edu, E-mail: topel@stolaf.edu [Department of Astronomy, University of Arizona, Tucson, AZ 85721 (United States)

    2014-08-01

    We analyze orbital solutions for 48 massive multiple-star systems in the Cygnus OB2 association, 23 of which are newly presented here, to find that the observed distribution of orbital periods is approximately uniform in log P for P < 45 days, but it is not scale-free. Inflections in the cumulative distribution near 6 days, 14 days, and 45 days suggest key physical scales of ≅0.2, ≅0.4, and ≅1 A.U. where yet-to-be-identified phenomena create distinct features. No single power law provides a statistically compelling prescription, but if features are ignored, a power law with exponent β ≅ –0.22 provides a crude approximation over P = 1.4-2000 days, as does a piece-wise linear function with a break near 45 days. The cumulative period distribution flattens at P > 45 days, even after correction for completeness, indicating either a lower binary fraction or a shift toward low-mass companions. A high degree of similarity (91% likelihood) between the Cyg OB2 period distribution and that of other surveys suggests that the binary properties at P ≲ 25 days are determined by local physics of disk/clump fragmentation and are relatively insensitive to environmental and evolutionary factors. Fully 30% of the unbiased parent sample is a binary with period P < 45 days. Completeness corrections imply a binary fraction near 55% for P < 5000 days. The observed distribution of mass ratios 0.2 < q < 1 is consistent with uniform, while the observed distribution of eccentricities 0.1 < e < 0.6 is consistent with uniform plus an excess of e ≅ 0 systems. We identify six stars, all supergiants, that exhibit aperiodic velocity variations of ∼30 km s{sup –1} attributed to atmospheric fluctuations.

  2. Release and transport of artificial radionuclides from nuclear weapons related activities in the Ob River, Siberia over the course of the nuclear age

    International Nuclear Information System (INIS)

    Sayles, F.L.; Kenna, T.C.; Livingston, H.D.

    1999-01-01

    Studies of sediment cores from lakes on the flood plain of the Ob River, Siberia have been used to develop a history of the release, transport, and deposition of artificial radionuclides related to the development and testing of nuclear weapons over the duration of the nuclear age (∼1950 to the present) in this major Arctic river system. The Ob is of particular importance in this regard as two of the former Soviet Union's major weapons production plants, Mayak and Tomsk-7, and the Semipalatinsk test site are located within the Ob drainage basin. Accidents and intentional releases of radionuclides at both plants have been substantial, raising the issue of transport throughout this extensive river system as well as delivery to the Arctic Ocean. Our studies have included determining sediment profiles of 239,240 Pu, 137 Cs, and the natural nuclide 210 Pb and its parent 226 Ra in a number of cores from the Ob delta, as well as analysis of 239 Pu, 240 Pu, and 237 Np. The latter provide sensitive measures of the presence of non-fallout materials derived from weapons production activities

  3. Leptin receptor 170 kDa (OB-R170) protein expression is reduced in obese human skeletal muscle: a potential mechanism of leptin resistance

    DEFF Research Database (Denmark)

    Fuentes, T; Ara, I; Guadalupe-Grau, A

    2010-01-01

    To examine whether obesity-associated leptin resistance could be due to down-regulation of leptin receptors (OB-Rs) and/or up-regulation of suppressor of cytokine signalling 3 (SOCS3) and protein tyrosine phosphatase 1B (PTP1B) in skeletal muscle, which blunt janus kinase 2-dependent leptin...

  4. Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Erkasap, N.; Ozkurt, M. [Department of Physiology, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Erkasap, S.; Yasar, F. [Department of General Surgery, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Uzuner, K. [Department of Physiology, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Ihtiyar, E. [Department of General Surgery, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Uslu, S.; Kara, M. [Department of Biochemistry, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Bolluk, O. [Department of Biostatistics, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey)

    2013-03-19

    The objective of the present study was to investigate the effect of leptin on the progression of colorectal carcinoma to metastatic disease by analyzing the serum leptin concentration and Ob-R gene expression in colon cancer tissues. Tissue samples were obtained from 31 patients who underwent surgical resection for colon (18 cases) and metastatic colon (13 cases) cancer. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA) and Ob-R mRNA expression by real-time polymerase chain reaction (RT-PCR) for both groups. ELISA data were analyzed by the Student t-test and RT-PCR data were analyzed by the Mann-Whitney U-test. RT-PCR results demonstrated that mRNA expression of Ob-R in human metastatic colorectal cancer was higher than in local colorectal cancer tissues. On the other hand, mean serum leptin concentration was significantly higher in local colorectal cancer patients compared to patients with metastatic colorectal cancer. The results of the present study suggest a role for leptin in the progression of colon cancer to metastatic disease without weight loss. In other words, significantly increased Ob-R mRNA expression and decreased serum leptin concentration in patients with metastatic colon cancer indicate that sensitization to leptin activity may be a major indicator of metastasis to the colon tissue and the determination of leptin concentration and leptin gene expression may be used to aid the diagnosis.

  5. Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer

    International Nuclear Information System (INIS)

    Erkasap, N.; Ozkurt, M.; Erkasap, S.; Yasar, F.; Uzuner, K.; Ihtiyar, E.; Uslu, S.; Kara, M.; Bolluk, O.

    2013-01-01

    The objective of the present study was to investigate the effect of leptin on the progression of colorectal carcinoma to metastatic disease by analyzing the serum leptin concentration and Ob-R gene expression in colon cancer tissues. Tissue samples were obtained from 31 patients who underwent surgical resection for colon (18 cases) and metastatic colon (13 cases) cancer. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA) and Ob-R mRNA expression by real-time polymerase chain reaction (RT-PCR) for both groups. ELISA data were analyzed by the Student t-test and RT-PCR data were analyzed by the Mann-Whitney U-test. RT-PCR results demonstrated that mRNA expression of Ob-R in human metastatic colorectal cancer was higher than in local colorectal cancer tissues. On the other hand, mean serum leptin concentration was significantly higher in local colorectal cancer patients compared to patients with metastatic colorectal cancer. The results of the present study suggest a role for leptin in the progression of colon cancer to metastatic disease without weight loss. In other words, significantly increased Ob-R mRNA expression and decreased serum leptin concentration in patients with metastatic colon cancer indicate that sensitization to leptin activity may be a major indicator of metastasis to the colon tissue and the determination of leptin concentration and leptin gene expression may be used to aid the diagnosis

  6. Leptin receptor (Ob-R mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer

    Directory of Open Access Journals (Sweden)

    N. Erkasap

    Full Text Available The objective of the present study was to investigate the effect of leptin on the progression of colorectal carcinoma to metastatic disease by analyzing the serum leptin concentration and Ob-R gene expression in colon cancer tissues. Tissue samples were obtained from 31 patients who underwent surgical resection for colon (18 cases and metastatic colon (13 cases cancer. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA and Ob-R mRNA expression by real-time polymerase chain reaction (RT-PCR for both groups. ELISA data were analyzed by the Student t-test and RT-PCR data were analyzed by the Mann-Whitney U-test. RT-PCR results demonstrated that mRNA expression of Ob-R in human metastatic colorectal cancer was higher than in local colorectal cancer tissues. On the other hand, mean serum leptin concentration was significantly higher in local colorectal cancer patients compared to patients with metastatic colorectal cancer. The results of the present study suggest a role for leptin in the progression of colon cancer to metastatic disease without weight loss. In other words, significantly increased Ob-R mRNA expression and decreased serum leptin concentration in patients with metastatic colon cancer indicate that sensitization to leptin activity may be a major indicator of metastasis to the colon tissue and the determination of leptin concentration and leptin gene expression may be used to aid the diagnosis.

  7. Examination of the site amplification factor of OBS and their application to magnitude estimation and ground-motion prediction for EEW

    Science.gov (United States)

    Hayashimoto, N.; Hoshiba, M.

    2013-12-01

    1. Introduction Ocean bottom seismograph (OBS) is useful for making Earthquake Early Warning (EEW) earlier. However, careful handling of these data is required because the installation environment of OBSs may be different from that of land stations. Site amplification factor is an important factor to estimate the magnitudes, and to predict ground motions (e.g. seismic intensity) in EEW. In this presentation, we discuss the site amplification factor of OBS in the Tonankai area of Japan from these two points of view. 2. Examination of magnitude correction of OBS In the EEW of JMA, the magnitude is estimated from the maximum amplitude of the displacement in real time. To provide the fast magnitude estimation, the magnitude-estimation algorithm switches from the P to S formula (Meew(P) to Meew(S)) depending on the expected S-phase arrival (Kamigaichi,2004). To estimate the magnitude correction for OBS, we determine Meew(P) and Meew(S) at OBSs and compare them with JMA magnitude (Mjma). We find Meew(S) at OBS is generally larger than Mjma by approximately 0.6. The slight differences of spatial distribution of Meew(S) amplification are also found among other OBSs. From the numerical simulations, Nakamura et al. (MGR,submitted) pointed out that the oceanic layer and the low-velocity sediment layers causes the large amplifications in low frequency range (0.1-0.2Hz) at OBSs. We conclude that the site effect of OBS characterized by such a low velocity sediment layers causes those amplification of Magnitude. 3. The frequency-dependent site factor of OBS estimated from Fourier spectrum ratio and their application for prediction of seismic intensity of land station We compare Fourier spectra of S-wave portion on OBSs with those on adjacent land stations. Station pair whose distance is smaller than 50 km is analyzed, and we obtain that spectral ratio of land station (MIEH05 of the KiK-net/NIED) to OBS (KMA01 of the DONET/JAMSTEC) is 5-20 for frequencies 10-20Hz for both

  8. On the Binary Nature of Massive Blue Hypergiants: High-resolution X-Ray Spectroscopy Suggests That Cyg OB2 12 is a Colliding Wind Binary

    Energy Technology Data Exchange (ETDEWEB)

    Oskinova, L. M.; Hamann, W.-R.; Shenar, T.; Sander, A. A. C.; Todt, H.; Hainich, R. [Institute for Physics and Astronomy, University Potsdam, D-14476 Potsdam (Germany); Huenemoerder, D. P. [Massachusetts Institute of Technology, Kavli Institute for Astrophysics and Space Research, 70 Vassar St., Cambridge, MA 02139 (United States); Ignace, R., E-mail: lida@astro.physik.uni-potsdam.de [Department of Physics and Astronomy, East Tennessee State University, Johnson City, TN 37663 (United States)

    2017-08-10

    The blue hypergiant Cyg OB2 12 (B3Ia{sup +}) is a representative member of the class of very massive stars in a poorly understood evolutionary stage. We obtained its high-resolution X-ray spectrum using the Chandra observatory. PoWR model atmospheres were calculated to provide realistic wind opacities and to establish the wind density structure. We find that collisional de-excitation is the dominant mechanism depopulating the metastable upper levels of the forbidden lines of the He-like ions Si xiv and Mg xii. Comparison between the model and observations reveals that X-ray emission is produced in a dense plasma, which could reside only at the photosphere or in a colliding wind zone between binary components. The observed X-ray spectra are well-fitted by thermal plasma models, with average temperatures in excess of 10 MK. The wind speed in Cyg OB2 12 is not high enough to power such high temperatures, but the collision of two winds in a binary system can be sufficient. We used archival data to investigate the X-ray properties of other blue hypergiants. In general, stars of this class are not detected as X-ray sources. We suggest that our new Chandra observations of Cyg OB2 12 can be best explained if Cyg OB2 12 is a colliding wind binary possessing a late O-type companion. This makes Cyg OB2 12 only the second binary system among the 16 known Galactic hypergiants. This low binary fraction indicates that the blue hypergiants are likely products of massive binary evolution during which they either accreted a significant amount of mass or already merged with their companions.

  9. Dum lucet - bibamus sodales. Ob und wie wir Archäologen die Alten verstehen

    Directory of Open Access Journals (Sweden)

    Iva Mikl Curk

    2004-12-01

    -Schälchens, welches uns nur durch eine Publikation bekannt ist (Mratschek 1987, könnte aber den Trinker - ob er schon ein Neusiedler aus Norditalien kommend oder ein Einheimischer, welcher das Schälchen zur Gästegabe bekommen hat, war - direkter ansprechen. Mit Bleiglasur glasierte Ware trägt zum Teil im Reliefdekor noch naturgetreu abgebildete Efeu- und Weinreben-Ranken, die aber bald größtenteils stilisiert werden. Manches Gefäß von dieser Sorte wurde schon in den provinziellen Werkstätten hergestellt, in der ersten Phase allerdings als Modellarbeit der italischen (oder in Italien ausgebildeten Meister. Das beweisen sehr klar die Unterschiede an der Ausarbeitung, wenn man die Gegenstände aus Poetovio z.B. mit denen aus Carnuntum vergleicht. Aus Norditalien stammt jedenfalls auch eine Zahl der Gesichtbecher, besonders derjenigen, die als Grabbeigabe in Emona ausgegraben worden sind (Brathwaite 2001; Schindler Kaudelka, Butti Ronchetti, Schneider 2000. Da aber auch in Emona ein spezifisch gearbeitetes Gefäß mit der Darstellung vom männlichen Gesicht als Graburne gedient hat, und die Scherben aus Siedlungsspuren und aus der Töpferwerkstätte in Poetovio wieder andere Eigenschaften aufweisen, würde die Autorin, was die Bestimmung solcher Gefäße betrifft, die Meinung vertreten, dass sie sowohl für den Gebrauch im Kultus als auch zum Erheitern der Tischrunde gedacht gewesen seien, wenn auch für verschiedene Umgebungen und nicht gleich in der Ausführung. Die Reihe des oben dargestellten Trinkgeschirrs stammte sozusagen ausschließlich aus dem mittelmeerländischen Kulturkreis oder aus direktem Import. Das einheimische Element schien seine Vorstellungen nicht durch naturgetreue Abbildungen an den Artefakten des täglichen Lebens kund gegeben zu haben. In den lokalen Werkstätten sind sogar direkte Nachbildungen, auch technisch so einfach, wie das bei Keramik möglich ist, kaum vorhanden. Das wird auch durch einen Topf von Poetovio (jetzt im Landesmuseum in Graz, der

  10. OB CITY–Definition of a Family-Based Intervention for Childhood Obesity Supported by Information and Communication Technologies

    Science.gov (United States)

    Hu, Ruofei; Cancela, Jorge; Cea, Gloria; Vlachopapadopoulou, Elpis-Athina; Fotiadis, Dimitrios I.; Fico, Giuseppe

    2016-01-01

    Childhood obesity is becoming one of the 21st century’s most important public health problems. Nowadays, the main treatment of childhood obesity is behavior intervention that aims at improve children’s lifestyle to arrest the disease. Information and communication technologies (ICTs) have not been widely employed in this intervention, and most of existing ICTs systems are not having a long-term effect. The purpose of this paper is to define a system to support family-based intervention through a state-of-the-art analysis of family-based interventions and related technological solutions first, and then using the analytic hierarchy process to derive a childhood obesity family-based behavior intervention model, and finally to provide a prototype of a system called OB CITY. The system makes use of applied behavior analysis, affective computing technologies, as well as serious game and gamification techniques, to offer long term services in all care dimensions of the family-based behavioral intervention aiming to provide positive effects to the treatment of childhood obesity. PMID:27602306

  11. CSO BOLOCAM 1.1 mm CONTINUUM MAPPING OF THE BRAID NEBULA STAR FORMATION REGION IN CYGNUS OB7

    International Nuclear Information System (INIS)

    Aspin, Colin; Beck, Tracy L.; Davis, Chris J.

    2011-01-01

    We present a 1.1 mm map of the Braid Nebula star formation region in Cygnus OB7 taken using Bolocam on the Caltech Submillimeter Observatory. Within the 1 deg 2 covered by the map, we have detected 55 cold dust clumps all of which are new detections. A number of these clumps are coincident with IRAS point sources although the majority are not. Some of the previously studied optical/near-IR sources are detected at 1.1 mm. We estimate total dust/gas masses for the 55 clumps together with peak visual extinctions. We conclude that over the whole region, approximately 20% of the clumps are associated with IRAS sources suggesting that these are protostellar objects. The remaining 80% are classed as starless clumps. In addition, both FU Orionis (FUor) like objects in the field, the Braid Star and HH 381 IRS, are associated with strong millimeter emission. This implies that FUor eruptions can occur at very early stages of pre-main-sequence life. Finally, we determine that the cumulative clump mass function for the region is very similar to that found in both the Perseus and ρ Ophiuchus star-forming regions.

  12. A WIDE-FIELD NARROWBAND OPTICAL SURVEY OF THE BRAID NEBULA STAR FORMATION REGION IN CYGNUS OB7

    International Nuclear Information System (INIS)

    Magakian, Tigran Yu.; Nikogossian, Elena H.; Movsessian, Tigran; Aspin, Colin; Pyo, Tae-Soo; Khanzadyan, Tigran; Smith, Michael D.; Mitchison, Sharon; Davis, Chris J.; Beck, Tracy L.; Moriarty-Schieven, Gerald H.

    2010-01-01

    We study the population of Herbig-Haro (HH) flows and jets in an area of Cygnus OB7 designated the Braid Nebula star formation region. This complex forms part of the L 1003 dark cloud, and hosts two FU Orionis (FUor)-like objects as well as several other active young stars. To trace outflow activity and to relate both known and newly discovered flows to young star hosts we intercompare new, deep, narrowband Hα and [S II] optical images taken on the Subaru 8 m Telescope on Mauna Kea, Hawaii. Our images show that there is considerable outflow and jet activity in this region suggesting the presence of an extensive young star population. We confirm that both of the FUor-like objects drive extensive HH flows and document further members of the flows in both objects. The L 1003 star formation complex is a highly kinematically active region with young stars in several different stages of evolution. We trace collimated outflows from numerous young stars although the origin of some HH objects remains elusive.

  13. OB CITY-Definition of a Family-Based Intervention for Childhood Obesity Supported by Information and Communication Technologies.

    Science.gov (United States)

    Hu, Ruofei; Cancela, Jorge; Arredondo Waldmeyer, Maria Teresa; Cea, Gloria; Vlachopapadopoulou, Elpis-Athina; Fotiadis, Dimitrios I; Fico, Giuseppe

    2016-01-01

    Childhood obesity is becoming one of the 21st century's most important public health problems. Nowadays, the main treatment of childhood obesity is behavior intervention that aims at improve children's lifestyle to arrest the disease. Information and communication technologies (ICTs) have not been widely employed in this intervention, and most of existing ICTs systems are not having a long-term effect. The purpose of this paper is to define a system to support family-based intervention through a state-of-the-art analysis of family-based interventions and related technological solutions first, and then using the analytic hierarchy process to derive a childhood obesity family-based behavior intervention model, and finally to provide a prototype of a system called OB CITY. The system makes use of applied behavior analysis, affective computing technologies, as well as serious game and gamification techniques, to offer long term services in all care dimensions of the family-based behavioral intervention aiming to provide positive effects to the treatment of childhood obesity.

  14. VizieR Online Data Catalog: Extinction law in the Cep OB3b young cluster (Allen+, 2014)

    Science.gov (United States)

    Allen, T. S.; Prchlik, J. J.; Megeath, S. T.; Gutermuth, R. A.; Pipher, J. L.; Naylor, T.; Jeffries, R. D.

    2017-06-01

    We use Johnson V and Cousins Rc (hereafter called VR) band phot from the Isaac Newton Telescope (INT), compiled in the catalog of Littlefair et al. (2010, J/MNRAS/403/545). The R-band photometry was obtained using the Sloan r filter. It was calibrated against photometric standard stars measured in the Cousins Rc filter with an arbitrary zero point. Moderate resolution ((λ/Δλ)~1000-2000, FWHM resolution of about 6 Å) optical spectra (covering 4000-9000 Å) were obtained for ~1700 sources toward Cep OB3b using the multi-fiber spectrograph Hectospec on the MMT telescope. About 600 sources were selected for observation because they were determined to be possible cluster members (Allen et al. 2012, J/ApJ/750/125), based on indicators of youth, such as IR emission due to circumstellar dusty material and heightened X-ray activity. We use an extinction map from Allen et al. (2012, J/ApJ/750/125) to initially estimate the extinction toward each source. This map is derived using the 2MASS Point Source Catalog (Skrutskie et al. 2006AJ....131.1163S, Cat. VII/233) H and Ks band photometry of background stars. (1 data file).

  15. Analysis of seismic reflectivity and AVO pattern of BSR using OBS data in the southwestern offshore region of Taiwan

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, W.B.; Yang, H.R. [Jinwen Univ. of Science and Technology, Hsintien City, Taipei County, Taiwan (China). Dept. of Environment and Property Management; Schnurle, P.; Liu, C.S. [National Taiwan Univ., Taipei, Taiwan (China). Inst. of Oceanography; Lee, C.S. [National Taiwan Ocean Univ., Keelung, Taiwan (China). Inst. of Applied Earth Science; Wang, Y.; Chung, S.H.; Chen, S.C. [Ministry of Economic Affairs, Taiwan (China). Central Geological Survey

    2008-07-01

    Regional multi-channel seismic reflection profiles that were conducted in Taiwan from 2003 to 2006 resulted in the identification of a gas hydrate-related bottom simulating reflector (BSR) in the broad southwestern offshore region of Taiwan. In order to understand the regional distribution of methane hydrate bearing layers and explore concentrated hydrate bearing layers, this paper presented a comprehensive analysis of reflection coefficient and amplitude-versus-offset (AVO) pattern of BSR using ocean bottom seismographs (OBSs) seismic data acquired in the southwestern offshore region of Taiwan. The study focused on the analysis and interpretation of airgun array signals recorded by OBSs during 2004 and 2006. Ten profiles of seismic reflection/refraction with a total length of about 140 km and recorded by 50 recovered OBSs were acquired on the active and passive margins in offshore southwestern Taiwan. Amplitudes of the direct water arrival, the multiple, and the BSR were picked interactively for all the OBS lines. A quantitative representation of reflector strength was provided by calculation of reflection coefficients. In general, the seafloor reflection coefficients for the active and passive margins were estimated as 0.1-0.25. The paper presented the data and analysis as well as the results of the study. It was concluded that the results of calculated reflection coefficient of the BSR in offshore southwest Taiwan suggested that inferred hydrate concentration for the passive margin profiles was relatively higher than that for the active margin profiles. 4 refs.

  16. Spatial clustering of summer temperature maxima from the CNRM-CM5 climate model ensembles & E-OBS over Europe

    Directory of Open Access Journals (Sweden)

    Margot Bador

    2015-09-01

    Full Text Available Reducing the dimensionality of the complex spatio-temporal variables associated with climate modeling, especially ensembles of climate models, is a challenging and important objective. For studies of detection and attribution, it is especially important to maintain information related to the extreme values of the atmospheric processes. Typical methods for data reduction involve summarizing climate model output information through means and variances, which does not preserve any information about the extremes. In order to help solve this challenge, a dependence summary measure appropriate for extreme values must be inferred. Here, we adapt one such measure from a recent study to a larger domain with a different variable and gridded data from observations and climate model ensembles, i.e. E-OBS observations and the CNRM-CM5 model. The handling of such ensembles of data is proposed, as well as a comparison of the spatial clusterings between two different ensembles, here a present-day and a future ensemble of climate simulations. This method yields valid information concerning extremes, while greatly reducing the data set.

  17. Gas expulsions and biological activity recorded offshore Molene Island, Brittany (France): video supervised recording of OBS data and analogue modelling

    Science.gov (United States)

    Klingelhoefer, F.; Géli, L.; Dellong, D.; Evangelia, B.; Tary, J. B.; Bayrakci, G.; Lantéri, N.; Lin, J. Y.; Chen, Y. F.; Chang, E. T. Y.

    2016-12-01

    Ocean bottom seismometers (OBS) commonly record signals from Short Duration Events (SDEs), having characteristics that are very different from those produced by tectonic earthquakes, e.g.: durations Brittany within the field of view of the EMSO-Molene underwater observatory, at a water depth of 12 m. The camera images and the recordings reveal the presence of crabs, octopus and several species of fish. Other acoustic signals can be related to the presence of moving algae or the influence from bad weather. Tides produce characteristic curves in the noise recorded on the geophones. SDEs have been recorded on both instruments, that may well have been caused by gas expulsions from the seabed into the water. In order to verify this hypothesis, an aquarium was filled with water overlying an even grain-sized quartz sand layer. A constant air supply through a narrow tube produced gas bubbles in a regular manner and an immersed ocean bottom geophone recorded the resulting acoustic signals. The bubbles tend to have a uniform size and to produce a waveform very close to those found on the OBSs. By comparing the number of SDEs and the volume of escaped air, estimates can be made regarding the volume of gas escaping the seafloor in different environments.

  18. Génétique épidémiologique et moléculaire de l’obésité humaine

    Directory of Open Access Journals (Sweden)

    Iron Albert

    2000-01-01

    Full Text Available L’obésité est une pathologie majeure pour plusieurs raisons qu’il est difficile de hiérarchiser. D’abord parce qu’elle est commune, concernant aujourd’hui près d’un individu sur trois dans les pays industrialisés. Ensuite, parce qu’elle est grave en raison des complications nombreuses et sévères, parmi lesquelles on peut citer des cardiopathies, le diabète, l’HTA, des cancers, etc. Enfin, parce que répondant à la définition de maladie multifactorielle résultant de l’interaction entre des facteurs héréditaires et des facteurs environnementaux, sa connaissance a beaucoup progressé ces dernières années, notamment grâce à l’apport de la génétique moléculaire. À l’échelon individuel et d’une manière simple, on peut définir l’obésité comme résultant d’un excès de tissu adipeux qui va se traduire par un poids élevé par rapport à ce qu’on peut considérer comme étant un poids idéal donné par la formule de Lorentz : Poids idéal (kg = Taille (cm – 100 – [Taille (cm – 150]/4 (homme ou 2,5 (femme Sous l’angle épidémiologique, c’est-à-dire à l’échelle des populations, l’obésité sera définie à partir de critères de nature anthropologique utilisés aussi en clinique pour typer le patient obèse. On peut prendre en compte le rapport du tour de hanche sur le tour de taille (qui permet de définir une obésité de type androïde ou gynoïde selon que ce rapport est supérieur ou inférieur à 0,85 ou la mesure de l’adiposité évaluée par l’appréciation des plis cutanés (en particulier le pli tricipital ou surtout l’indice de corpulence qui est le critère majeur des épidémiologistes pour l’étude de l’obésité chez l’adulte. Cet indice est la référence pour la définition de l’obésité chez l’adulte ; il est aussi appelé indice de masse corporelle (IMC ou indice de Quetelet ; il exprime le rapport du poids (en kg au carré de la taille (en m

  19. Trening za razvijanje občutka za števila in količine pri predšolskih otrocih s posebnimi potrebami

    OpenAIRE

    Kuplenk, Petra

    2017-01-01

    Tako otroci kot tudi odrasli se z matematiko srečujemo na vsakem koraku, pa naj bo to na poti v vrtec, službo ali pa pri delu doma. Matematika vsakodnevno vpliva na naše življenje in delo. Na delovnem mestu, v vrtcu, opažam vse večje težave otrok s posebnimi potrebami na področju razvoja občutka za števila in količine. V predšolskem obdobju je namreč nujno, da otroci razvijejo občutek za števila in količine, saj vsa nadaljnja matematična znanja temeljijo na usvojenih spretnostih. V empirič...

  20. Extinctions and Distances to Dark Clouds from 2MASS, MegaCam and IPHAS Surveys: LDN 1525 in the Direction of the Aur OB1 Association

    Directory of Open Access Journals (Sweden)

    Straižys V.

    2010-12-01

    Full Text Available The possibility of applying photometry from the 2MASS J, H, Ks, MegaCam u, g and IPHAS r, i, Hα surveys for determining the distance to the dark cloud LDN1525 (TGU 1192 in the direction of the Aur OB1 association is investigated using the red clump giants. The main dust cloud, probably related to the emission nebulae Sh 2-232, Sh 2-233, Sh 2-235, the molecular cloud and the association Aur OB2, is found to be located at a distance of 1.3 kpc from the Sun. The nebula Sh 2-231 can be an object of the Perseus arm. The maximum extinction AV found in the cloud is close to 6 mag.

  1. Carbenoxolone treatment ameliorated metabolic syndrome in WNIN/Ob obese rats, but induced severe fat loss and glucose intolerance in lean rats.

    Directory of Open Access Journals (Sweden)

    Siva Sankara Vara Prasad Sakamuri

    Full Text Available BACKGROUND: 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1 regulates local glucocorticoid action in tissues by catalysing conversion of inactive glucocorticoids to active glucocorticoids. 11β-HSD1 inhibition ameliorates obesity and associated co-morbidities. Here, we tested the effect of 11β-HSD inhibitor, carbenoxolone (CBX on obesity and associated comorbidities in obese rats of WNIN/Ob strain, a new animal model for genetic obesity. METHODOLOGY/PRINCIPAL FINDINGS: Subcutaneous injection of CBX (50 mg/kg body weight or volume-matched vehicle was given once daily for four weeks to three month-old WNIN/Ob lean and obese rats (n = 6 for each phenotype and for each treatment. Body composition, plasma lipids and hormones were assayed. Hepatic steatosis, adipose tissue morphology, inflammation and fibrosis were also studied. Insulin resistance and glucose intolerance were determined along with tissue glycogen content. Gene expressions were determined in liver and adipose tissue. CBX significantly inhibited 11β-HSD1 activity in liver and adipose tissue of WNIN/Ob lean and obese rats. CBX significantly decreased body fat percentage, hypertriglyceridemia, hypercholesterolemia, insulin resistance in obese rats. CBX ameliorated hepatic steatosis, adipocyte hypertrophy, adipose tissue inflammation and fibrosis in obese rats. Tissue glycogen content was significantly decreased by CBX in liver and adipose tissue of obese rats. Severe fat loss and glucose- intolerance were observed in lean rats after CBX treatment. CONCLUSIONS/SIGNIFICANCE: We conclude that 11β-HSD1 inhibition by CBX decreases obesity and associated co-morbidities in WNIN/Ob obese rats. Our study supports the hypothesis that inhibition of 11β-HSD1 is a key strategy to treat metabolic syndrome. Severe fat loss and glucose -intolerance by CBX treatment in lean rats suggest that chronic 11β-HSD1 inhibition may lead to insulin resistance in normal conditions.

  2. New Low-mass Stars in the 25 Orionis Stellar Group and Orion OB1a Sub-association from SDSS-III/BOSS Spectroscopy

    Science.gov (United States)

    Suárez, Genaro; Downes, Juan José; Román-Zúñiga, Carlos; Covey, Kevin R.; Tapia, Mauricio; Hernández, Jesús; Petr-Gotzens, Monika G.; Stassun, Keivan G.; Briceño, César

    2017-07-01

    The Orion OB1a sub-association is a rich low-mass star (LMS) region. Previous spectroscopic studies have confirmed 160 LMSs in the 25 Orionis stellar group (25 Ori), which is the most prominent overdensity of Orion OB1a. Nonetheless, the current census of the 25 Ori members is estimated to be lower than 50% complete, leaving a large number of members to be still confirmed. We retrieved 172 low-resolution stellar spectra in Orion OB1a observed as ancillary science in the SDSS-III/BOSS survey, for which we classified their spectral types and determined physical parameters. To determine memberships, we analyzed the {{{H}}}α emission, Li I λ6708 absorption, and Na I λλ8183, 8195 absorption as youth indicators in stars classified as M type. We report 50 new LMSs spread across the 25 Orionis, ASCC 18, and ASCC 20 stellar groups with spectral types from M0 to M6, corresponding to a mass range of 0.10≤slant m/{M}⊙ ≤slant 0.58. This represents an increase of 50% in the number of known LMSs in the area and a net increase of 20% in the number of 25 Ori members in this mass range. Using parallax values from the Gaia DR1 catalog, we estimated the distances to these three stellar groups and found that they are all co-distant, at 338 ± 66 pc. We analyzed the spectral energy distributions of these LMSs and classified their disks into evolutionary classes. Using H-R diagrams, we found a suggestion that 25 Ori could be slightly older than the other two observed groups in Orion OB1a.

  3. Enhancing the Quality of Service for Real Time Traffic over Optical Burst Switching (OBS Networks with Ensuring the Fairness for Other Traffics.

    Directory of Open Access Journals (Sweden)

    Mohammed A Al-Shargabi

    Full Text Available Optical burst switching (OBS networks have been attracting much consideration as a promising approach to build the next generation optical Internet. A solution for enhancing the Quality of Service (QoS for high priority real time traffic over OBS with the fairness among the traffic types is absent in current OBS' QoS schemes. In this paper we present a novel Real Time Quality of Service with Fairness Ratio (RT-QoSFR scheme that can adapt the burst assembly parameters according to the traffic QoS needs in order to enhance the real time traffic QoS requirements and to ensure the fairness for other traffic. The results show that RT-QoSFR scheme is able to fulfill the real time traffic requirements (end to end delay, and loss rate ensuring the fairness for other traffics under various conditions such as the type of real time traffic and traffic load. RT-QoSFR can guarantee that the delay of the real time traffic packets does not exceed the maximum packets transfer delay value. Furthermore, it can reduce the real time traffic packets loss, at the same time guarantee the fairness for non real time traffic packets by determining the ratio of real time traffic inside the burst to be 50-60%, 30-40%, and 10-20% for high, normal, and low traffic loads respectively.

  4. [Modeling of Processes of Migration and Accumulation of Radionuclides in Freshwater Ecosystems by the Example of the Samson, Lev, Vandras Rivers Related to the Ob-Irtysh River Basin].

    Science.gov (United States)

    Trapeznikov, A V; Korzhavin, A V; Trapeznikova, V N; Nikolkin, V N

    2016-01-01

    Mathematical models of horizontal distribution and migration of radionuclides are presented in water and floodplain soils of the Samson-Lev-Vandras river system related to the Ob-Irtysh river basin. Integral inventory of radionuclides in the main components of the river ecosystems is calculated. The estimated annual discharge of radionuclides from the Vandras river to the Great Salym river is given. The effect of the removal of man-made radionuclides in the Samson, Lev, Vandras rivers on radioactive contamination of the Ob-Irtysh river system is shown in comparison with the Techa river, that also belongs to the Ob-Irtysh river basin. Despite the presence of an additional radioactive contamination of the Samson floodplain, the transfer of radioactive substances in the Samson, Lev, Vandras rivers has a much smaller impact on the contamination of the Ob-Irtysh river system, compared to the Techa river, prone to a large-scale radioactive contamination.

  5. Borate mineral assemblages in the system Na2OCaOMgOB2O3H2O

    Science.gov (United States)

    Christ, C.L.; Truesdell, A.H.; Erd, Richard C.

    1967-01-01

    he significant known hydrated borate mineral assemblages (principally of the western United States) in the system Na2OCaOz.sbnd;MgOB2O3H2O are expressible in three ternary composition diagrams. Phase rule interpretation of the diagrams is consistent with observation, if the activity of H2O is generally considered to be determined by the geologic environment. The absence of conflicting tie-lines on a diagram indicates that the several mineral assemblages of the diagram were formed under relatively narrow ranges of temperature and pressure. The known structural as well as empirical formulas for the minerals are listed, and the more recent (since 1960) crystal structure findings are discussed briefly. Schematic Gibbs free energy-composition diagrams based on known solubility-temperature relations in the systems Na2B4O7-H2O and Na2B4O7-NaCl-H2O, are highly useful in the interpretation and prediction of the stability relations in these systems; in particular these diagrams indicate clearly that tincalconite, although geologically important, is everywhere a metastable phase. Crystal-chemical considerations indicate that the same thermodynamic and kinetic behavior observed in the Na2B4O7-H2O system will hold in the Ca2B6O11-H2O system. This conclusion is confirmed by the petrologic evidence. The chemical relations among the mineral assemblages of a ternary diagram are expressed by a schematic "activity-activity" diagram. These activity-activity diagrams permit the tracing-out of the paragenetic sequences as a function of changing cation and H2O activities. ?? 1967.

  6. X-RAY EMISSION FROM THE DOUBLE-BINARY OB-STAR SYSTEM QZ CAR (HD 93206)

    International Nuclear Information System (INIS)

    Parkin, E. R.; Naze, Y.; Rauw, G.; Broos, P. S.; Townsley, L. K.; Pittard, J. M.; Moffat, A. F. J.; Oskinova, L. M.; Waldron, W. L.

    2011-01-01

    X-ray observations of the double-binary OB-star system QZ Car (HD 93206) obtained with the Chandra X-ray Observatory over a period of roughly 2 years are presented. The respective orbits of systems A (O9.7 I+b2 v, P A = 21 days) and B (O8 III+o9 v, P B = 6 days) are reasonably well sampled by the observations, allowing the origin of the X-ray emission to be examined in detail. The X-ray spectra can be well fitted by an attenuated three-temperature thermal plasma model, characterized by cool, moderate, and hot plasma components at kT ≅ 0.2, 0.7, and 2 keV, respectively, and a circumstellar absorption of ≅0.2 x 10 22 cm -2 . Although the hot plasma component could be indicating the presence of wind-wind collision shocks in the system, the model fluxes calculated from spectral fits, with an average value of ≅7 x 10 -13 erg s -1 cm -2 , do not show a clear correlation with the orbits of the two constituent binaries. A semi-analytical model of QZ Car reveals that a stable momentum balance may not be established in either system A or B. Yet, despite this, system B is expected to produce an observed X-ray flux well in excess of the observations. If one considers the wind of the O8 III star to be disrupted by mass transfer, the model and observations are in far better agreement, which lends support to the previous suggestion of mass transfer in the O8 III + o9 v binary. We conclude that the X-ray emission from QZ Car can be reasonably well accounted for by a combination of contributions mainly from the single stars and the mutual wind-wind collision between systems A and B.

  7. Development and implementation of an automated system to exchange attenuators of the OB85/1 gamma irradiator

    International Nuclear Information System (INIS)

    Silva Junior, Iremar A.; Ramos, Marcio A.G.; Carvalho, Valdir S.; Diniz, Raphael E.; Cescon, Claudinei T.; Vivolo, Vitor; Potiens, Maria da Penha A.

    2011-01-01

    In order to improve the calibration process of portable detectors of the Instrument Calibration Laboratory of IPEN, an automated system to exchange the attenuators of the OB85/1 irradiator system was developed. This automation was developed following this sequence: (i) development of the device with the cooperation of the IPEN Sector of Projects, using the Solid Edge software to design the mechanical part of the exchanging device of the attenuators, in 3D; (ii) simulation with the Festo's FluidSim software to define the pneumatic components and their respective actuators; (iii) machining and assembly of mechanical parts; (iv) assembly of pneumatic components and their actuators, like magnetic pneumatic cylinders, which allow the use of magnetic sensors, used to confirm the attenuators opened or closed positions: actuators 5/2 each, with double solenoid; (v) assembly of the control panel for operating the device remotely from the operating room. With this automation, the technicians in charge of the detectors calibration and research testing will have no hand contact with lead attenuators, improving the calibration process due to the decrease in time spent with manual shift from the attenuators and avoiding accidents, like the fall of the lead attenuators. It has been a concern of the LCI-IPEN group the decrease in the time spent by the technicians in the calibration room controlled areas should follow the recommendations of the radiological protection rules, which recommend the shortest time possible of workers in these areas. Automated systems have, usually, a better rate of reproducibility, due to the small participation by the system operator, so the LCI-IPEN is following the trend of several laboratories and automating its processes. (author)

  8. Association entre le travail par quarts et l’obésité chez les hommes dans le nord-est de l’Ontario

    Directory of Open Access Journals (Sweden)

    Anne Grundy

    2017-01-01

    Full Text Available Introduction : Même si certaines études suggèrent une association entre le travail par quarts et l’obésité, peu sont fondées sur la population ou tiennent compte de divers horaires de travail par quarts. L’obésité étant associée à plusieurs problèmes de santé chroniques, il est important de comprendre quelles formes de travail par quarts ont une incidence sur elle et d’effectuer des travaux permettant d’évaluer de façon plus détaillée l’exposition au travail par quarts. Méthodologie : Au moyen d’une régression logistique polytomique multivariée, nous avons étudié l’association entre le travail par quarts (de soir ou nuit, par quarts ou autre type de rotation et le surpoids et l’obésité, en fonction d’une mesure transversale de l’indice de masse corporelle chez 1 561 hommes. Ces hommes avaient déjà servi de témoins dans une étude cas-témoins sur le cancer de la prostate menée dans le nord-est de l’Ontario de 1995 à 1999. Nous avons obtenu l’information sur leurs antécédents de travail (notamment sur le travail par quarts, leur taille et leur poids à partir de données autodéclarées recueillies par questionnaire. Résultats : Nous avons observé une association entre le fait d’avoir déjà travaillé par quarts (par opposition au fait de n’avoir jamais travaillé par quarts et le surpoids (RC [rapport de cotes] = 1,34; IC [intervalle de confiance] à 95 % : 1,05 à 1,73 ainsi que l’obésité (RC = 1,57; IC à 95 % : 1,12 à 2,21. Nous avons également observé des associations statistiquement non significatives avec le fait d’avoir déjà travaillé (par opposition au fait de n’avoir jamais travaillé de façon permanente selon un quart de soir ou de nuit. Nous avons par ailleurs observé une tendance à la hausse statistiquement significative en ce qui concerne le risque de surpoids et d’obésité en fonction de la durée du travail par quarts. Conclusion : Tant l

  9. Cesium-137 global fallout into the Ob river basin and its influence on the Kara sea contamination - Weapons fallout cesium-137 in the Ob' catchment landscapes and its influence on radioactive contamination of the Kara sea: Western Siberia, Russia

    Energy Technology Data Exchange (ETDEWEB)

    Semenkov, Ivan N.; Miroshnikov, Alexey Yu. [The Organization of Russian Academy of Sciences Institute of geology of ore deposits, petrography, mineralogy and geochemistry Russian Academy of Sciences (Russian Federation)

    2014-07-01

    There are several high level {sup 137}Cs anomaly zones detected in the deposits of the SW part of the Kara Sea. These anomaly zones were formed in the Ob' and the Enisey river estuaries due to the geochemical 'river-sea' boarder barrier. Level of radiocaesium specific activity reaches 120 Bq*kg{sup -1} in the deposits from these zones. Radiochemical enterprises occur in the both river basins. Their activity results in caesium-137 transfer into the river net. Vast area is contaminated by {sup 137}Cs after nuclear weapons in Semipalatinsk test-site and Kyshtym disaster in the Ob' river basin. Moreover, caesium comes to the Ob' and the Enisey river basins with global atmospheric fallout. The inflow of global fallout caesium-137 to the catchments is 660 kCi (320 kCi including radioactive decay) that is 4 times higher than {sup 137}Cs emission due to Fukushima disaster. Therefore, these river basins as any other huge catchment are an important sources of radioactive contamination of the Arctic Ocean. The aim of our research is to study behavior of global fallout caesium-137 in the landscapes of the Ob and the Enisey river basins. We studied caesium-137 behavior on the example of first order catchments in taiga, wetland, forest-steppe, steppe, and semi-arid landscapes. Geographic information system (GIS) was made. The tenth-order catchments (n=154, Horton coding system) shape 20-groups due to topsoil properties controlling cesium mobility. Eleven first-order basins, characterized 7 groups of tenth order catchments, were studied. And 700 bulk-core soil samples were collected in 2011-2013. Cesium runoff is calculated for 3 first-order river basins in taiga and forest-steppe landscapes. Storage of global fallout caesium-137 declines from undisturbing taiga first-order river basin (90% of cumulative fallout including radioactive decay)> arable steppe and fores-steppe (70 - 75%)> undisturbing wetland (60%). Caesium-137 transfer is high in arable lands

  10. Cooperative Hurricane Network Obs

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Observations from the Cooperative Hurricane Reporting Network (CHURN), a special network of stations that provided observations when tropical cyclones approached the...

  11. The OBS control plane

    DEFF Research Database (Denmark)

    Manolova, Anna Vasileva; Ruepp, Sarah Renée

    2010-01-01

    . The applicability analysis carried out here focuses on the actual feasibility of the integration and the potential trade-offs which appear when two contradicting principles are combined. Taking advantage of the flexibility of the GMPLS control plane does not seem to be as easy and as straightforward as expected...

  12. ANCEIOct-ob-er

    Indian Academy of Sciences (India)

    work of Neumark [2], a British aeronautical engineer, which was published as early as 1965, but not ... You have raised a question that I have always been asking me whenever I get the current ... me want to show off their scholarship and assume the readers know the subject. I used to get ... keep myself away. Resonance is ...

  13. Ob padcu utopije

    Directory of Open Access Journals (Sweden)

    Pascal De Decker

    2009-01-01

    Full Text Available Po koncu 2. svetovne vojne so se začele graditi velike stanovanjske soseske. Pogosto so jih sestavljale stolpnice. Številne le 50 let pozneje podirajo oziroma jih temeljito prenavljajo. Modernistične ideje, ki so jih navdihnili predstavniki kongresa CIAM (Congrès International d’Architecture Moderne in Le Corbusier, so izgubile nekdanjo mikavnost. V tem prispevku si bomo ogledali razvoj dogodkov, predvsem pa se bomo posvetili napačni razlagi (simbolnega pomena bivališča, kakor so ga razumeli predstavniki modernističnega gibanja. Prav to napačno razumevanje je nazadnje pripeljalo do hitrega podiranja teh sosesk.

  14. Star formation history of Canis Major OB1. II. A bimodal X-ray population revealed by XMM-Newton

    Science.gov (United States)

    Santos-Silva, T.; Gregorio-Hetem, J.; Montmerle, T.; Fernandes, B.; Stelzer, B.

    2018-02-01

    Aims: The Canis Major OB1 Association has an intriguing scenario of star formation, especially in the region called Canis Major R1 (CMa R1) traditionally assigned to a reflection nebula, but in reality an ionized region. This work is focussed on the young stellar population associated with CMa R1, for which our previous results from ROSAT, optical, and near-infrared data had revealed two stellar groups with different ages, suggesting a possible mixing of populations originated from distinct star formation episodes. Methods: The X-ray data allow the detected sources to be characterized according to hardness ratios, light curves, and spectra. Estimates of mass and age were obtained from the 2MASS catalogue and used to define a complete subsample of stellar counterparts for statistical purposes. Results: A catalogue of 387 XMM-Newton sources is provided, of which 78% are confirmed as members or probable members of the CMa R1 association. Flares (or similar events) were observed for 13 sources and the spectra of 21 bright sources could be fitted by a thermal plasma model. Mean values of fits parameters were used to estimate X-ray luminosities. We found a minimum value of log(LX [erg/s] ) = 29.43, indicating that our sample of low-mass stars (M⋆ ≤ 0.5 M⊙), which are faint X-ray emitters, is incomplete. Among the 250 objects selected as our complete subsample (defining our "best sample"), 171 are found to the east of the cloud, near Z CMa and dense molecular gas, of which 50% of them are young (10 Myr). The opposite happens to the west, near GU CMa, in areas lacking molecular gas: among 79 objects, 30% are young and 50% are older. These findings confirm that a first episode of distributed star formation occurred in the whole studied region 10 Myr ago and dispersed the molecular gas, while a second, localized episode (<5 Myr) took place in the regions where molecular gas is still present.

  15. The distribution and history of nuclear weapons related contamination in sediments from the Ob River, Siberia as determined by isotopic ratios of plutonium and neptunium

    International Nuclear Information System (INIS)

    Kenna, T.C.; Sayles, F.L.

    2002-01-01

    Isotopic ratios of Pu and Np measured in sediment cores from 5 locations in the Ob River drainage basin show clear evidence of input from sources other than global fallout (non-fallout sources). Historical contaminant records obtained by combining isotopic ratio information with chronological information indicate that non-fallout inputs are from several sources that have varied significantly over the past 50 years. Unique isotopic signatures observed in sediments from tributaries that drain areas containing known or suspected sources of non-fallout contamination are used to identify the source of materials in sediments collected at downstream locations. These data can lead to a better understanding of the transport behavior, fate, and relative importance of particle reactive, weapons related contaminants originating from the nuclear facilities Mayak, Tomsk-7, and Semipalitinsk, which lie within the drainage basin. From our work to date, we draw the following conclusions: (1) Persistent non-fallout contamination is observed in the Ob River above its confluence with the Irtysh River, indicating contamination from the Tomsk-7 facility. (2) Non-fallout contamination in the Tobol River above its confluence with the Irtysh River indicates contamination from the Mayak facility. (3) Non-fallout contamination in the Irtysh River above its confluence with the Tobol River indicates contamination from the Semipalitinsk weapons test site. (4) The occurrence of isotopic ratios in Ob Delta sediments that are similar to those observed in source tributaries suggests that contamination from at least two sources has been transported along the length of the river system. (5) Global fallout, a result of high-yield atmospheric weapons tests conducted by the FSU and USA primarily, is the dominant source of Pu and Np to the region; however, there have been brief periods when inputs from non-fallout sources exceeded those from global fallout

  16. The history and source of particulate 137Cs and 239,240Pu deposition in sediments of the Ob River Delta, Siberia

    International Nuclear Information System (INIS)

    Sayles, F.L.; Livingston, H.D.; Panteleyev, G.P.

    1997-01-01

    This paper presents the first results of a project designed to examine the transfer of particle-associated artificial radionuclides down the Ob River in Siberia to its delta over the past 5 decades. The main sources include fallout from atmospheric nuclear weapons tests and weapons complexes and test sites of the Former Soviet Union in or near the Ob watershed. The approach is to measure the accumulation of the radionuclides in undisturbed delta sediments - obtaining a record of their deposition over time. These records were found in sediments of shallow lakes apart from, and connected to, the main channel. Sediment cores were collected in the summer of 1994 using a shallow draft catamaran to reach these lakes from a support ship in the main channel. Measurements are presented on the depth distributions of 137 Cs and Pu isotopes and their inventories in a series of dated sediment cores - including one from a location in the Taz Estuary (which does not receive Ob River sediments). Sediment dating was carried out using the excess 210 Pb technique. The results obtained are compared with known information on the temporal history of releases from the various sources and characteristics of the isotopic composition of the sources. The results show that good records of radionuclide deposition indicate that the major fraction of 137 Cs and Pu isotopes deposited in these delta sediments comes from atmospheric nuclear weapons test fallout - both delivered directly from the atmosphere and from downstream transport of watershed sediments. No more than 25% of the observed inventories could be derived from other sources

  17. ECA&D and E-OBS: High-resolution datasets for monitoring climate change and effects on viticulture in Europe

    Directory of Open Access Journals (Sweden)

    Photiadou Christiana

    2017-01-01

    Full Text Available Climate change and climate variability profoundly affect the production of wine. When facing a changing climate, the characteristics of wine produced in each region will change while the natural year-to-year variations in climate will increase variability of income for wine businesses and therefore affect profitability and economic resilience. The challenge posed to the viticulture community is thus to closely monitor these changes to be able to adapt business practices. The European Climate Assessment and Dataset (ECA&D and its gridded version E-OBS are tools to monitor the changing climatic conditions over Europe, with an emphasis on changes in extreme climatic conditions. In this paper, the potential of ECA&D and E-OBS for viticulture is demonstrated by a few examples. The examples include the changing areal suitable for Chardonnay cultivation, showing an expansion to areas which have been too cold only a few decades ago and retraction of optimal conditions from areas which have been suitable in the recent past. Other examples show the change in the diurnal temperature range in the latter stages of the ripening process of grapes and the variability in heavy precipitation events. Finally, first results of a new dataset for South America are presented.

  18. Acoustic and Shear-Wave Velocities in Hydrate-Bearing Sediments Offshore Southwestern Taiwan: Tomography, Converted Waves Analysis and Reverse-Time Migration of OBS Records

    Directory of Open Access Journals (Sweden)

    Philippe Schnurle

    2006-01-01

    Full Text Available A 2.5-D combined seismic reflection and refraction survey has been conducted in the accretionary complex offshore of southwestern Taiwan where BSRs (Bottom Simulating Reflectors are highly concentrated and geochemical signals for the presence of gas hydrate are strong. In this study, we perform velocity analysis of the 6 4-component OBS (Ocean-Bottom Seismometer records along the southernmost transect of this seismic experiment. We utilize 3 independent methods in order to accurately determine the acoustic and shear-wave velocities of the sediments: 1-D Root Mean Square (RMS analysis of the P-P and P-S reflected events on individual datumed components, 2-D inversion of the P-P and P-S reflected and refracted events along the in-line transect, and 3-D acoustic inversion of the first arrivals. The principal sources of bias in the determination of the velocities are the 3-dimentional nature of the topography and the complexity of the underlying structures. The three methods result in consistent velocity profiles. Rapid lateral and vertical variations of the velocities are observed. We then investigate the large scale gas hydrate content through rock physic modeling: at the vertical of each OBS, shear-waves velocities are utilized to estimate the water-filled porosities, and the acoustic velocities predicted for a set of gas hydrate, quartz and clay contents are compared to the observed profiles.

  19. MULTI-EPOCH VERY LONG BASELINE ARRAY OBSERVATIONS OF THE COMPACT WIND-COLLISION REGION IN THE QUADRUPLE SYSTEM Cyg OB2 no. 5

    Energy Technology Data Exchange (ETDEWEB)

    Dzib, Sergio A.; Rodriguez, Luis F.; Loinard, Laurent; Ortiz-Leon, Gisela N.; Araudo, Anabella T. [Centro de Radiostronomia y Astrofisica, Universidad Nacional Autonoma de Mexico, Morelia 58089 (Mexico); Mioduszewski, Amy J., E-mail: s.dzib@crya.unam.mx [National Radio Astronomy Observatory, 1003 Lopezville Road, Socorro, NM 87801 (United States)

    2013-02-15

    We present multi-epoch Very Long Base Array observations of the compact wind-collision region in the Cyg OB2 no. 5 system. These observations confirm the arc-shaped morphology of the emission reported earlier. The total flux as a function of time is roughly constant when the source is 'on', but falls below the detection limit as the wind-collision region approaches periastron in its orbit around the contact binary at the center of the system. In addition, at one of the 'on' epochs, the flux drops to about a fifth of its average value. We suggest that this apparent variation could result from the inhomogeneity of the wind that hides part of the flux rather than from an intrinsic variation. We measured a trigonometrical parallax, for the most compact radio emission of 0.61 {+-} 0.22 mas, corresponding to a distance of 1.65 {sup +0.96} {sub -0.44} kpc, in agreement with recent trigonometrical parallaxes measured for objects in the Cygnus X complex. Using constraints on the total mass of the system and orbital parameters previously reported in the literature, we obtain two independent indirect measurements of the distance to the Cyg OB2 no. 5 system, both consistent with 1.3-1.4 kpc. Finally, we suggest that the companion star responsible for the wind interaction, yet undetected, is of spectral type between B0.5 and O8.

  20. MULTI-EPOCH VERY LONG BASELINE ARRAY OBSERVATIONS OF THE COMPACT WIND-COLLISION REGION IN THE QUADRUPLE SYSTEM Cyg OB2 no. 5

    International Nuclear Information System (INIS)

    Dzib, Sergio A.; Rodríguez, Luis F.; Loinard, Laurent; Ortiz-León, Gisela N.; Araudo, Anabella T.; Mioduszewski, Amy J.

    2013-01-01

    We present multi-epoch Very Long Base Array observations of the compact wind-collision region in the Cyg OB2 no. 5 system. These observations confirm the arc-shaped morphology of the emission reported earlier. The total flux as a function of time is roughly constant when the source is 'on', but falls below the detection limit as the wind-collision region approaches periastron in its orbit around the contact binary at the center of the system. In addition, at one of the 'on' epochs, the flux drops to about a fifth of its average value. We suggest that this apparent variation could result from the inhomogeneity of the wind that hides part of the flux rather than from an intrinsic variation. We measured a trigonometrical parallax, for the most compact radio emission of 0.61 ± 0.22 mas, corresponding to a distance of 1.65 +0.96 –0.44 kpc, in agreement with recent trigonometrical parallaxes measured for objects in the Cygnus X complex. Using constraints on the total mass of the system and orbital parameters previously reported in the literature, we obtain two independent indirect measurements of the distance to the Cyg OB2 no. 5 system, both consistent with 1.3-1.4 kpc. Finally, we suggest that the companion star responsible for the wind interaction, yet undetected, is of spectral type between B0.5 and O8.

  1. Chronic vitamin A-enriched diet feeding regulates hypercholesterolaemia through transcriptional regulation of reverse cholesterol transport pathway genes in obese rat model of WNIN/GR-Ob strain

    Directory of Open Access Journals (Sweden)

    Shanmugam M Jeyakumar

    2016-01-01

    Full Text Available Background & objectives: Hepatic scavenger receptor class B1 (SR-B1, a high-density lipoprotein (HDL receptor, is involved in the selective uptake of HDL-associated esterified cholesterol (EC, thereby regulates cholesterol homoeostasis and improves reverse cholesterol transport. Previously, we reported in euglycaemic obese rats (WNIN/Ob strain that feeding of vitamin A-enriched diet normalized hypercholesterolaemia, possibly through hepatic SR-B1-mediated pathway. This study was aimed to test whether it would be possible to normalize hypercholesterolaemia in glucose-intolerant obese rat model (WNIN/GR/Ob through similar mechanism by feeding identical vitamin A-enriched diet. Methods: In this study, 30 wk old male lean and obese rats of WNIN/GR-Ob strain were divided into two groups and received either stock diet or vitamin A-enriched diet (2.6 mg or 129 mg vitamin A/kg diet for 14 wk. Blood and other tissues were collected for various biochemical analyses. Results: Chronic vitamin A-enriched diet feeding decreased hypercholesterolaemia and normalized abnormally elevated plasma HDL-cholesterol (HDL-C levels in obese rats as compared to stock diet-fed obese groups. Further, decreased free cholesterol (FC and increased esterified cholesterol (EC contents of plasma cholesterol were observed, which were reflected in higher EC to FC ratio of vitamin A-enriched diet-fed obese rats. However, neither lecithin-cholesterol acyltransferase (LCAT activity of plasma nor its expression (both gene and protein in the liver were altered. On the contrary, hepatic cholesterol levels significantly increased in vitamin A-enriched diet fed obese rats. Hepatic SR-B1 expression (both mRNA and protein remained unaltered among groups. Vitamin A-enriched diet fed obese rats showed a significant increase in hepatic low-density lipoprotein receptor mRNA levels, while the expression of genes involved in HDL synthesis, namely, ATP-binding cassette protein 1 (ABCA1 and

  2. THE BOLOCAM GALACTIC PLANE SURVEY. III. CHARACTERIZING PHYSICAL PROPERTIES OF MASSIVE STAR-FORMING REGIONS IN THE GEMINI OB1 MOLECULAR CLOUD

    International Nuclear Information System (INIS)

    Dunham, Miranda K.; Evans, Neal J.; Harvey, Paul; Merello, Manuel; Rosolowsky, Erik; Cyganowski, Claudia J.; Aguirre, James; Bally, John; Battersby, Cara; Ginsburg, Adam; Glenn, Jason; Stringfellow, Guy S.; Bradley, Eric Todd; Dowell, Darren; Drosback, Meredith; Schlingman, Wayne; Shirley, Yancy L.; Walawender, Josh; Williams, Jonathan P.

    2010-01-01

    We present the 1.1 mm Bolocam Galactic Plane Survey (BGPS) observations of the Gemini OB1 molecular cloud complex, and targeted NH 3 observations of the BGPS sources. When paired with molecular spectroscopy of a dense gas tracer, millimeter observations yield physical properties such as masses, radii, mean densities, kinetic temperatures, and line widths. We detect 34 distinct BGPS sources above 5σ = 0.37 Jy beam -1 with corresponding 5σ detections in the NH 3 (1,1) transition. Eight of the objects show water maser emission (20%). We find a mean millimeter source FWHM of 1.12 pc and a mean gas kinetic temperature of 20 K for the sample of 34 BGPS sources with detections in the NH 3 (1,1) line. The observed NH 3 line widths are dominated by non-thermal motions, typically found to be a few times the thermal sound speed expected for the derived kinetic temperature. We calculate the mass for each source from the millimeter flux assuming the sources are isothermal and find a mean isothermal mass within a 120'' aperture of 230 ± 180 M sun . We find a total mass of 8400 M sun for all BGPS sources in the Gemini OB1 molecular cloud, representing 6.5% of the cloud mass. By comparing the millimeter isothermal mass to the virial mass calculated from the NH 3 line widths within a radius equal to the millimeter source size, we find a mean virial parameter (M vir /M iso ) of 1.0 ± 0.9 for the sample. We find mean values for the distributions of column densities of 1.0 x 10 22 cm -2 for H 2 , and 3.0 x 10 14 cm -2 for NH 3 , giving a mean NH 3 abundance of 3.0 x 10 -8 relative to H 2 . We find volume-averaged densities on the order of 10 3 -10 4 cm -3 . The sizes and densities suggest that in the Gem OB1 region the BGPS is detecting the clumps from which stellar clusters form, rather than smaller, higher density cores where single stars or small multiple systems form.

  3. Gels and gel-derived glasses in the Na2O-B2O3-SiO2 system. [containerless melting in space

    Science.gov (United States)

    Mukherjee, S. P.

    1982-01-01

    The containerless melting of high-purity multicomponent homogeneous gels and gel-monoliths offers a unique approach to making ultrapure multicomponent optical glasses in the reduced gravity environment of space. Procedures for preparing and characterizing gels and gel-derived glasses in the Na2O-B2O3-SiO2 system are described. Preparation is based on the polymerization reactions of alkoxysilane with trimethyl borate or boric acid and a suitable sodium compound. The chemistry of the gelling process is discussed in terms of process parameters and the gel compositions. The physicochemical nature of gels prepared by three different procedures were found to be significantly different. IR absorption spectra indicate finite differences in the molecular structures of the different gels. The melting of the gel powders and the transformation of porous gel-monoliths to transparent 'glass' without melting are described.

  4. Gels and gel-derived glasses in the system Na2O-B2O3-SiO2

    Science.gov (United States)

    Mukherjee, S. P.

    1983-01-01

    The containerless melting of high-purity multicomponent homogeneous gels and gel monoliths offers a unique approach to making ultrapure multicomponent optical glasses in the reduced gravity environment of space. Procedures for preparing and characterizing gels and gel-derived glasses in the system Na2O-B2O3-SiO2 are described. Preparation is based on the polymerization reactions of alkoxysilane with trimethyl borate or boric acid and a suitable sodium compound. The chemistry of the gelling process is discussed in terms of process parameters and the gel compositions. The physicochemical nature of gels prepared by three different procedures was found to be significantly different. Infrared absorption spectra indicate finite differences in the molecular structures of the different gels. The melting of the gel powders and the transformation of porous gel monoliths to transparent 'glass' without melting are described.

  5. DUST PROPERTIES AND DISK STRUCTURE OF EVOLVED PROTOPLANETARY DISKS IN Cep OB2: GRAIN GROWTH, SETTLING, GAS AND DUST MASS, AND INSIDE-OUT EVOLUTION

    International Nuclear Information System (INIS)

    Sicilia-Aguilar, Aurora; Henning, Thomas; Dullemond, Cornelis P.; Bouwman, Jeroen; Sturm, Bernhard; Patel, Nimesh; Juhász, Attila

    2011-01-01

    We present Spitzer/Infrared Spectrograph spectra of 31 T Tauri stars (TTS) and IRAM/1.3 mm observations for 34 low- and intermediate-mass stars in the Cep OB2 region. Including our previously published data, we analyze 56 TTS and 3 intermediate-mass stars with silicate features in Tr 37 (∼4 Myr) and NGC 7160 (∼12 Myr). The silicate emission features are well reproduced with a mixture of amorphous (with olivine, forsterite, and silica stoichiometry) and crystalline grains (forsterite, enstatite). We explore grain size and disk structure using radiative transfer disk models, finding that most objects have suffered substantial evolution (grain growth, settling). About half of the disks show inside-out evolution, with either dust-cleared inner holes or a radially dependent dust distribution, typically with larger grains and more settling in the innermost disk. The typical strong silicate features nevertheless require the presence of small dust grains, and could be explained by differential settling according to grain size, anomalous dust distributions, and/or optically thin dust populations within disk gaps. M-type stars tend to have weaker silicate emission and steeper spectral energy distributions than K-type objects. The inferred low dust masses are in a strong contrast with the relatively high gas accretion rates, suggesting global grain growth and/or an anomalous gas-to-dust ratio. Transition disks in the Cep OB2 region display strongly processed grains, suggesting that they are dominated by dust evolution and settling. Finally, the presence of rare but remarkable disks with strong accretion at old ages reveals that some very massive disks may still survive to grain growth, gravitational instabilities, and planet formation.

  6. Extended Gamma-Ray Emission from the G25.0+0.0 Region: A Star-forming Region Powered by the Newly Found OB Association?

    Energy Technology Data Exchange (ETDEWEB)

    Katsuta, J. [Department of Physical Sciences, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526 (Japan); Uchiyama, Y. [Rikkyo University, Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501 (Japan); Funk, S., E-mail: katsuta@hep01.hepl.hiroshima-u.ac.jp [Erlangen Centre for Astroparticle Physics, D-91058 Erlangen (Germany)

    2017-04-20

    We report a study of extended γ -ray emission with the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope , which is likely to be the second case of a γ -ray detection from a star-forming region (SFR) in our Galaxy. The LAT source is located in the G25 region, 1.°7 × 2.°1 around ( l , b ) = (25.°0, 0.°0). The γ -ray emission is found to be composed of two extended sources and one pointlike source. The extended sources have similar sizes of about 1.°4 × 0.°6. An ∼0.°4 diameter subregion of one has a photon index of Γ = 1.53 ± 0.15, and is spatially coincident with HESS J1837−069, likely a pulsar wind nebula. The other parts of the extended sources have a photon index of Γ = 2.1 ± 0.2 without significant spectral curvature. Given their spatial and spectral properties, they have no clear associations with sources at other wavelengths. Their γ -ray properties are similar to those of the Cygnus cocoon SFR, the only firmly established γ -ray detection of an SFR in the Galaxy. Indeed, we find bubble-like structures of atomic and molecular gas in G25, which may be created by a putative OB association/cluster. The γ -ray emitting regions appear confined in the bubble-like structure; similar properties are also found in the Cygnus cocoon. In addition, using observations with the XMM-Newton , we find a candidate young massive OB association/cluster G25.18+0.26 in the G25 region. We propose that the extended γ -ray emission in G25 is associated with an SFR driven by G25.18+0.26. Based on this scenario, we discuss possible acceleration processes in the SFR and compare them with the Cygnus cocoon.

  7. A 80 OBS and 30 Land 3-component seismometers array encompassing the 280 km segment of the Lesser Antilles subduction megathrust seismogenic zone: view of current seismicity

    Science.gov (United States)

    Laigle, Mireille; Sapin, Martine; Ruiz, Mario; Diaz, Jordi; Kissling, Edi; Charvis, Philippe; Flueh, Ernst; Hirn, Alfred

    2010-05-01

    An extensive onshore and offshore seismic station array in the Lesser Antilles subduction zone allows to monitor microearthquake activity for a period of 4 months in a region previously outside of reach for detailed observation. Such a network has been possible thanks to a cluster of 3 seismic surveys (TRAIL - F/S Merian, SISMANTILLESII - N/O Atalante, and OBSANTILLES - N/O Antea) for deploying and recovering the instruments from several pools (Geoazur, INSU-IPGP, IFM-GEOMAR, AWI ). It has been followed by an additional deployment of the 28 GeoAzur OBSs (OBSANTILLES - N/O Antea) during 5 months in the south-western half. These operations have been carried out for the seismic investigation of the Antilles megathrust seismogenic zone in the framework of the THALES WAS RIGHT european project, and with also the financial support of the french ANR Catastrophes Telluriques et Tsunamis (SUBSISMANTI) and by the EU SALVADOR Programme of IFM-GEOMAR. Onshore, 30 3-components land stations (CSIC Barcelone, IPG Paris, INSU-RLBM and -LITHOSCOPE) have been temporarily deployed. The deep seismic structure of the whole area has been investigated during these seismic surveys by wide-angle reflection and refraction seismics recorded by these instruments as well as multi-channel reflection seismic imaging (MCS) along a dense grid of crossing profiles at the OBS positions providing excellent velocity information for the upper plate. Both the location and the interpretation of the recorded earthquake activity require constraints on the deep seismic structure, which will be discussed with respect to the 3D geometry of the interplate boundary and oceanic Moho, as well as those of the forearc basement and Moho. Preliminary locations have been obtained within a simple 1D velocity model by taking into account corrections for the variable thickness of the mud- and sediments layers beneath each OBS. The latter are estimated for both P- and S-waves to compensate for the huge structural

  8. Multiphase formation of the Obří důl polymetallic skarn deposit, West Sudetes, Bohemian Massif: geochemistry and Re-Os dating of sulfide mineralization

    Science.gov (United States)

    Veselovský, František; Ackerman, Lukáš; Pašava, Jan; Žák, Karel; Haluzová, Eva; Creaser, Robert A.; Dobeš, Petr; Erban, Vojtěch; Tásler, Radko

    2018-06-01

    The Obří důl Fe-Cu-As polymetallic sulfide skarn deposit is developed in a metamorphic series in the West Sudetes, Bohemian Massif. It consists of lenses of marble, calc-silicate rocks, and skarns. We studied the Gustav orebody, which is located few hundred meters away from the contact with a large, late-orogenic Variscan Krkonoše-Jizera Plutonic Complex (KJPC) emplaced into shallow crust. Mineralogical and fluid inclusion study evidence indicates that the main sulfide stage, dominated by pyrrhotite, arsenopyrite, and chalcopyrite originated from aqueous hydrothermal fluids with salinity up to 8 wt% NaCl eq. with minimum homogenization temperatures ranging from 324 to 358 °C. These fluids mainly replaced carbonate-rich lithologies. Carbon, oxygen, and strontium isotope data in Ca-rich rocks imply total overprinting by channelized metasomatic fluid flow, which is most probably related to the intrusion of the KJPC, whereas δ34S values of sulfides argue for a magmatic source of sulfur. The Re-Os age of arsenopyrite overlaps published age data for the KJPC and suggests synchronous formation of the main sulfide mineralization and pluton emplacement.

  9. NEAR-INFRARED PERIODIC AND OTHER VARIABLE FIELD STARS IN THE FIELD OF THE CYGNUS OB7 STAR-FORMING REGION

    Energy Technology Data Exchange (ETDEWEB)

    Wolk, Scott J.; Rice, Thomas S. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Aspin, Colin A. [Institute for Astronomy, University of Hawaii at Manoa, 640 North Aohoku Place, Hilo, HI 96720 (United States)

    2013-04-15

    We present a subset of the results of a three-season, 124 night, near-infrared monitoring campaign of the dark clouds Lynds 1003 and Lynds 1004 in the Cygnus OB7 star-forming region. In this paper, we focus on the field star population. Using three seasons of UKIRT J, H, and K-band observations spanning 1.5 years, we obtained high-quality photometry on 9200 stars down to J = 17 mag, with photometric uncertainty better than 0.04 mag. After excluding known disk-bearing stars we identify 149 variables-1.6% of the sample. Of these, about 60 are strictly periodic, with periods predominantly <2 days. We conclude this group is dominated by eclipsing binaries. A few stars have long period signals of between 20 and 60 days. About 25 stars have weak modulated signals, but it was not clear if these were periodic. Some of the stars in this group may be diskless young stellar objects with relatively large variability due to cool starspots. The remaining {approx}60 stars showed variations which appear to be purely stochastic.

  10. Structural study of Na2O-B2O3-SiO2 glasses from molecular simulations using a polarizable force field.

    Science.gov (United States)

    Pacaud, Fabien; Delaye, Jean-Marc; Charpentier, Thibault; Cormier, Laurent; Salanne, Mathieu

    2017-10-28

    Sodium borosilicate glasses Na 2 O-B 2 O 3 -SiO 2 (NBS) are complex systems from a structural point of view. Three main building units are present: tetrahedral SiO 4 and BO 4 (B IV ) and triangular BO 3 (B III ). One of the salient features of these compounds is the change of the B III /B IV ratio with the alkali concentration, which is very difficult to capture in force fields-based molecular dynamics simulations. In this work, we develop a polarizable force field that is able to reproduce the boron coordination and more generally the structure of several NBS systems in the glass and in the melt. The parameters of the potential are fitted from density functional theory calculations only, in contrast with the existing empirical potentials for NBS systems. This ensures a strong improvement on the transferability of the parameters from one composition to another. Using this new force field, the structure of NBS systems is validated against neutron diffraction and nuclear magnetic resonance experiments. A special focus is given to the distribution of B III /B IV with respect to the composition and the temperature.

  11. The current content of artificial radionuclides in the water of the Tobol-Irtysh river system (from the mouth of the Iset River to the confluence with the Ob River)

    Energy Technology Data Exchange (ETDEWEB)

    Nikitin, Alexander I. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation)]. E-mail: nikitin@typhoon.obninsk.ru; Chumichev, Vladimir B. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Valetova, Nailia K. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Katrich, Ivan Yu. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Kabanov, Alexander I. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Dunaev, Gennady E. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Shkuro, Valentina N. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Rodin, Victor M. [Tobolsk Biological Station of RAS, 15, Voikov street, Tobolsk, Tyumen region 626150 (Russian Federation); Mironenko, Alexander N. [Tobolsk Biological Station of RAS, 15, Voikov street, Tobolsk, Tyumen region 626150 (Russian Federation); Kireeva, Elena V. [Tobolsk Biological Station of RAS, 15, Voikov street, Tobolsk, Tyumen region 626150 (Russian Federation)

    2007-07-15

    Data on content of {sup 90}Sr, {sup 137}Cs, {sup 239,240}Pu and {sup 3}H in water of the Tobol-Irtysh part of the Techa-Iset-Tobol-Irtysh-Ob river system (through which the 'Mayak' PA radioactive wastes are transported) are presented and discussed. The data were received in 2004-2005 under the ISTC project on radioecological monitoring of the Tobol and Irtysh rivers. Monthly observations of {sup 137}Cs, {sup 90}Sr and {sup 3}H content in water in the area of the Tobol and Irtysh confluence have been conducted starting from May 2004. To obtain information on the investigated river system as a whole, the radioecological survey of the Tobol and Irtysh rivers at the section from the mouth of the Iset River to the confluence with the Ob River was carried out in 2004. It is shown that the impact of 'Mayak' PA waste transport by {sup 90}Sr is distinctly traced as far as the area of the Irtysh and Ob confluence.

  12. The current content of artificial radionuclides in the water of the Tobol-Irtysh river system (from the mouth of the Iset River to the confluence with the Ob River)

    International Nuclear Information System (INIS)

    Nikitin, Alexander I.; Chumichev, Vladimir B.; Valetova, Nailia K.; Katrich, Ivan Yu.; Kabanov, Alexander I.; Dunaev, Gennady E.; Shkuro, Valentina N.; Rodin, Victor M.; Mironenko, Alexander N.; Kireeva, Elena V.

    2007-01-01

    Data on content of 90 Sr, 137 Cs, 239,240 Pu and 3 H in water of the Tobol-Irtysh part of the Techa-Iset-Tobol-Irtysh-Ob river system (through which the 'Mayak' PA radioactive wastes are transported) are presented and discussed. The data were received in 2004-2005 under the ISTC project on radioecological monitoring of the Tobol and Irtysh rivers. Monthly observations of 137 Cs, 90 Sr and 3 H content in water in the area of the Tobol and Irtysh confluence have been conducted starting from May 2004. To obtain information on the investigated river system as a whole, the radioecological survey of the Tobol and Irtysh rivers at the section from the mouth of the Iset River to the confluence with the Ob River was carried out in 2004. It is shown that the impact of 'Mayak' PA waste transport by 90 Sr is distinctly traced as far as the area of the Irtysh and Ob confluence

  13. A DYNAMICAL STUDY OF SUSPECTED RUNAWAY STARS AS TRACES OF PAST SUPERNOVA EXPLOSIONS IN THE REGION OF THE SCORPIUS-CENTAURUS OB ASSOCIATION

    International Nuclear Information System (INIS)

    Jilinski, E.; Ortega, V. G.; Drake, N. A.; De la Reza, R.

    2010-01-01

    We address the question of identifying possible past supernovae events taking place in the region of the Scorpius-Centaurus (Sco-Cen) OB association based on stars proposed by Hoogerwerf et al. With this purpose, we obtained a time series of high-resolution spectra of six stars (HIP 42038, HIP 46950, HIP 48943, HIP 69491, HIP 76013, and HIP 82868) which, according to Hoogerwerf et al., may have been runaway stars with origins in the region of the Sco-Cen association. This also includes the nearby young open clusters IC 2391 and IC 2602. If confirmed, such supernovae events could, in principle, have played a role in triggering the formation of some small stellar groups thought to be associated with the Sco-Cen association. Our analysis shows that, except for HIP 48943, the remaining stars are spectroscopic binary systems. For HIP 46950 and HIP 69491, this was already noted by other authors. Our high-resolution spectra allowed us to obtain the radial velocities for all the stars which, combined with their proper motions and parallaxes from Hipparcos, provide a means to investigate, by retracing their orbits, if the Sco-Cen region was, in fact, the origin of these stars. We find that none of these systems originated in the Sco-Cen region. Exploring the possibility that the birthplace of the studied stars occurred in the clusters IC 2391 and IC 2602, we noticed that at the epoch of 2-3 Myr ago these clusters were at a distance comparable with their tidal radii.

  14. Up-to-date concentrations of long-lived artificial radionuclides in the Tom and Ob rivers in the area influenced by discharges from Siberian chemical combine

    International Nuclear Information System (INIS)

    Nikitin, A.I.; Kryshev, I.I.; Bashkirov, N.I.; Valetova, N.K.; Dunaev, G.E.; Kabanov, A.I.; Katrich, I.Yu; Krutovsky, A.O.; Nikitin, V.A.; Petrenko, G.I.; Polukhina, A.M.; Selivanova, G.V.; Shkuro, V.N.

    2012-01-01

    The Siberian Chemical Combine (SCC) is located in Seversk (formerly known as Tomsk-7) in the Tomsk Region of the Russian Federation. The main contribution of radionuclides in the SCC process water discharged into the Tom River was from the single-pass reactors, now removed from service (the last SCC reactor was shutdown on June 5, 2008). The data on the concentrations of 90 Sr, 137 Cs, 239,240 Pu and other artificial radionuclides in water, bottom sediments and flood-plain soils of the Tom and Ob rivers from Tomsk to the confluence of the rivers, are presented and discussed. The results of measurements carried out after shutdown of the last SCC single-pass reactor indicated no radiologically significant consequences of SCC activities for the studied water environment compartments. Contemporary activity concentrations of long-lived artificial radionuclides 3 H, 90 Sr, 137 Cs and 239,240 Pu in river water were below the intervention levels established by current regulations of the Russian Federation for these radionuclides. The results of 3 H analysis in water from the Tom and Samuska rivers demonstrated no inflow of contaminated formation water to surface water from the sites where liquid radioactive wastes of the SCC were injected below the surface. However, the density of flood-plain soil contamination by long-lived 137 Cs in the area influenced by SCC liquid discharges was higher than regional technogenic background. There were local flood-plain areas contaminated not only by 137 Cs, but also other gamma-emitters, such as 60 Co and 152 Eu.

  15. Characterization of a thermostable recombinant l-rhamnose isomerase from Caldicellulosiruptor obsidiansis OB47 and its application for the production of l-fructose and l-rhamnulose.

    Science.gov (United States)

    Chen, Ziwei; Xu, Wei; Zhang, Wenli; Zhang, Tao; Jiang, Bo; Mu, Wanmeng

    2018-04-01

    l-Hexoses are rare sugars that are important components and precursors in the synthesis of biological compounds and pharmaceutical drugs. l-Rhamnose isomerase (L-RI, EC 5.3.1.14) is an aldose-ketose isomerase that plays a significant role in the production of l-sugars. In this study, a thermostable, l-sugar-producing L-RI from the hyperthermophile Caldicellulosiruptor obsidiansis OB47 was characterized. The recombinant L-RI displayed maximal activity at pH 8.0 and 85 °C and was significantly activated by Co 2+ . It exhibited a relatively high thermostability, with measured half-lives of 24.75, 11.55, 4.15 and 3.30 h in the presence of Co 2+ at 70, 75, 80 and 85 °C, respectively. Specific activities of 277.6, 57.9, 13.7 and 9.6 U mg -1 were measured when l-rhamnose, l-mannose, d-allose and l-fructose were used as substrates, respectively. l-Rhamnulose was produced with conversion ratios of 44.0% and 38.6% from 25 and 50 g L -1 l-rhamnose, respectively. l-Fructose was also efficiently produced by the L-RI, with conversion ratios of 67.0% and 58.4% from 25 and 50 g L -1 l-mannose, respectively. The recombinant L-RI could effectively catalyze the formation of l-rhamnulose and l-fructose, suggesting that it was a promising candidate for industrial production of l-rhamnulose and l-fructose. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  16. Effects of coronal regions on the x-ray flux and ionization conditions in the winds of ob supergiants and of stars

    International Nuclear Information System (INIS)

    Cassinelli, J.P.; Olson, G.L.

    1979-01-01

    The anomalously strong O VI and N V lines in O stars and the C IV lines in B supergiants may be due to Auger ionization by X-rays from a thin coronal zone at the base of the cool stellar winds. We determine the size of a corona that is necessary to produce the overall ionization conditions in zeta Pup as has been deduced by Olson from line profile analysis. In the ionization balance calculations we account for diffuse radiation field in the wind and for the large optical depths in the He II continuum due to radiative and Auger ionization edges of abundant elements. The X-ray flux transmitted through the wind is calculated and compared with upper limits derived for upper limits derived for zeta Pup observations from ANS and Uhuru satellites. It is found that a coronal zone with a temperature of 5x10 6 K and a volume emission measure of 10 58 cm -3 can produce the required ionization in a wind having a temperature of 30,000--35,000 K. The emergent X-ray flux bears little resemblance to the coronal emissivity because of the opacity of the wind. The X-ray flux nearly reaches the upper limits derived from the ANS observations and, at several energy bands, should be detectable by the HEAO B satellite. A simplified analysis of the Auger ionization process is developed and applied to other Of and OB supergiants. We find that the model can explain the presence of C IV and Si IV in supergaints with effective temperatures as low as 12,000 K and can explain the appearance of O VI and N V lines in early type supergiants as late as BO.5 and B2, respectively

  17. Kharlamova, N. F. Climate Changes over the 20th and 21st Centuries in the Upper Basin of the Ob and Irtysh Rivers (Altai Region)

    Science.gov (United States)

    Fedorovna, K. N., II

    2015-12-01

    The Russian climate is more sensitive to global warming than the climate in many other parts of the world. According to the Second Climate Change National Assessment, since the mid-1970s, the average temperature has been rising with rate of 0.43 ° C / 10 years, which is more than two times higher than the rate of global warming. In the Altai region, the rate of temperature change is higher than the average for Russia with an annual surface air temperature increase equal to 1.8°C the 20th century. The maximum value of this increase the past 50 years (1963-2013) was found in the intermountain basins of Altai (+ 2.6°C) mainly due to the winter and spring warming with changes in the summer season being considerably smaller. This warming is accompanied with negative tendencies in annual precipitation over the entire Altai Krai. The mountain ranges of Altai are called the "water tower" of Northern Eurasia. The northward flow of numerous rivers streaming down from these ranges in the Basin of the Ob and the Irtysh Rivers is formed by melting of Altai glaciers and snowfields. Since the middle of the 19th century the largest glaciers in the Altai have retreated by 1.5-2 km and the thickness of their tails decreased by 50-70 m. The reduction of mountain glaciers poses a threat of depletion of water flow to major agricultural regions downstream affecting human activity and even the drinking water availability. Permafrost in the Altai Mountains is actively degraded (thawing), which represents a danger for infrastructure (first of all for roads and pipelines) and increases risk of catastrophic events (landslides, mudflows). Continued warming could contribute to a significant reduction of water resources, biodiversity and other negative processes in the region.The reported study was partially supported by the Russian Foundation for Baseline Research (project No. 15-45-04450).

  18. Promise(s of mesenchymal stem cells as an in vitro model system to depict pre-diabetic/diabetic milieu in WNIN/GR-Ob mutant rats.

    Directory of Open Access Journals (Sweden)

    Soundarya L Madhira

    Full Text Available BACKGROUND: Development of model systems have helped to a large extent, in bridging gap to understand the mechanism(s of disease including diabetes. Interestingly, WNIN/GR-Ob rats (Mutants, established at National Centre for Laboratory Animals (NCLAS of National Institute of Nutrition (NIN, form a suitable model system to study obesity with Type 2 diabetes (T2D demonstrating several secondary complications (cataract, cardiovascular complications, infertility, nephropathy etc. The present study has been carried out to explore the potent application(s of multipotent stem cells such as bone marrow mesenchymal stem cells (BM-MSCs, to portray features of pre-diabetic/T2D vis-à-vis featuring obesity, with impaired glucose tolerance (IGT, hyperinsulinemia (HI and insulin resistance (IR seen with Mutant rats akin to human situation. METHODOLOGY/PRINCIPAL FINDINGS: Primary cultures of BM-MSCs (third passage from Mutants, its lean littermate (Lean and parental control (Control were characterized for: proliferation markers, disease memory to mark obesity/T2D/HI/IR which included phased gene expression studies for adipogenic/pancreatic lineages, inflammatory markers and differentiation ability to form mature adipocytes/Insulin-like cellular aggregates (ILCAs. The data showed that BM-MSCs from Mutant demonstrated a state of disease memory, depicted by an upregulated expression of inflammatory markers (IL-6, TNFα; increased stem cell recruitment (Oct-4, Sox-2 and proliferation rates (CD90+/CD29+, PDA, 'S' phase of cell cycle by FACS and BrdU incorporation; accelerated preadipocyte induction (Dact-1, PPARγ2 with a quantitative increase in mature adipocyte formation (Leptin; ILCAs, which were non-responsive to high glucose did confer the Obese/T2D memory in Mutants. Further, these observations were in compliance with the anthropometric data. CONCLUSIONS: Given the ease of accessibility and availability of MSCs, the present study form the basis to report for

  19. Doppiaggio in italiano del film 'Astérix et Obélix - Au service de Sa Majesté'. Trasposizione degli elementi culturali e umoristici

    Directory of Open Access Journals (Sweden)

    Alessandra Rollo

    2016-01-01

    Full Text Available Abstract – At present, audiovisual translation is one of the most interesting and stimulating domains within the field of Translation Studies. Resting on a rich semiotic apparatus, marked by the interplay of a double channel of communication – audio/visual – with different types of signs – verbal/non-verbal codes, the audiovisual text is a complex one, whose transfer from one language into another represents a challenging task for every professional in this field. Especially in dubbing, the translator/adapter has to work on the interlinguistic level as well as on the intersemiotic level (iconic, paralinguistic elements, etc.: as many codes having great semantic potential and transmitting useful cultural information, as we shall see in the film which we have taken as the object of our analyses: Astérix et Obélix: Au Service de Sa Majesté (2012. This fourth film adaptation (except cartoons of Astérix’s adventures offers a series of gags playing on the parody of typical traditions, symbols, linguistic clichés and cultural stereotypes associated with British culture. Italian dubbing resorts to different translation strategies, some of which come under a foreignizing approach, aiming at preserving the original’s colour and mood, whereas others are in line with a domesticating approach, in order to bring the product closer to the final audience. Indeed, instead of stressing the idea of a polarization or a dichotomy between two contrasting perspectives, we find it advisable to envisage a gradation between two instances which occur at the same time and coexist in a complementary way during the translation process.   Keywords: audiovisual translation; dubbing; cultural elements; humorous elements; foreignization/domestication.     Résumé – La traduction audiovisuelle se configure à l’heure actuelle comme l’un des domaines les plus intéressants et les plus stimulants dans le panorama des etudes traductologiques. Reposant sur

  20. Biogeochemical migration of heavy metals, Ti, V, Mo, Ta, W, and U, in the profile of a low-laid peatbog in the country between the Ob and Tom rivers

    International Nuclear Information System (INIS)

    Efremova, T.T.; Efremov, S.P.; Koutsenogii, K.P.; Peresedov, V.F.

    2003-01-01

    Biogeochemical migration of heavy metals in the course of marsh formation is mainly determined by physical-chemical processes, such as the oxidation-reduction zonality of the peatbog thickness and the state of humous substances (the quality of humus adsorptive barriers). In the process of peatbog formation V, U, Ta are the weakly captured elements while Mo is captured to a relatively higher extent. Elements as Ti and W are found in separate layers. No technogenic degradation of the marsh ecosystem in the Ob and Tom has been observed. (author)

  1. Ocena prostorske razsežnosti žledoloma februarja 2014 v bukovih in smrekovih sestojih v občinah Tolmin in Dobrova - Polhov Gradec s pomočjo tehnologije daljinskega zaznavanja

    OpenAIRE

    Šafran, Aljoša

    2018-01-01

    V magistrskem delu obravnavamo žledolom, ki je ob koncu januarja in začetku februarja 2014 povzročil gmotno škodo ne le na vegetaciji, temveč tudi na energetski in železniški infrastrukturi. Po dosedanjih ocenah gre za enega izmed najobsežnejših žledolomov na območju Slovenije v zadnjih desetletjih. V raziskavi nas je zanimala prostorska razporeditev sprememb v biomasi bukovih in smrekovih sestojev na z žledom prizadetih območjih, zaznanih s pomočjo satelita Landsat. V raziskavo sta bili zaje...

  2. Vitamin A decreases pre-receptor amplification of glucocorticoids in obesity: study on the effect of vitamin A on 11beta-hydroxysteroid dehydrogenase type 1 activity in liver and visceral fat of WNIN/Ob obese rats

    Directory of Open Access Journals (Sweden)

    Ayyalasomayajula Vajreswari

    2011-06-01

    Full Text Available Abstract Background 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1 catalyzes the conversion of inactive glucocorticoids to active glucocorticoids and its inhibition ameliorates obesity and metabolic syndrome. So far, no studies have reported the effect of dietary vitamin A on 11β-HSD1 activity in visceral fat and liver under normal and obese conditions. Here, we studied the effect of chronic feeding of vitamin A-enriched diet (129 mg/kg diet on 11β-HSD1 activity in liver and visceral fat of WNIN/Ob lean and obese rats. Methods Male, 5-month-old, lean and obese rats of WNIN/Ob strain (n = 16 for each phenotype were divided into two subgroups consisting of 8 rats of each phenotype. Control groups received stock diet containing 2.6 mg vitamin A/kg diet, where as experimental groups received diet containing 129 mg vitamin A/Kg diet for 20 weeks. Food and water were provided ad libitum. At the end of the experiment, tissues were collected and 11β-HSD1 activity was assayed in liver and visceral fat. Results Vitamin A supplementation significantly decreased body weight, visceral fat mass and 11β-HSD1 activity in visceral fat of WNIN/Ob obese rats. Hepatic 11β-HSD1 activity and gene expression were significantly reduced by vitamin A supplementation in both the phenotypes. CCAAT/enhancer binding protein α (C/EBPα, the main transcription factor essential for the expression of 11β-HSD1, decreased in liver of vitamin A fed-obese rats, but not in lean rats. Liver × receptor α (LXRα, a nuclear transcription factor which is known to downregulate 11β-HSD1 gene expression was significantly increased by vitamin A supplementation in both the phenotypes. Conclusions This study suggests that chronic consumption of vitamin A-enriched diet decreases 11β-HSD1 activity in liver and visceral fat of WNIN/Ob obese rats. Decreased 11β-HSD1 activity by vitamin A may result in decreased levels of active glucocorticoids in adipose tissue and possibly

  3. A REVISED AGE FOR UPPER SCORPIUS AND THE STAR FORMATION HISTORY AMONG THE F-TYPE MEMBERS OF THE SCORPIUS-CENTAURUS OB ASSOCIATION

    Energy Technology Data Exchange (ETDEWEB)

    Pecaut, Mark J.; Mamajek, Eric E.; Bubar, Eric J. [Department of Physics and Astronomy, University of Rochester, Rochester, NY 14627-0171 (United States)

    2012-02-20

    We present an analysis of the ages and star formation history of the F-type stars in the Upper Scorpius (US), Upper Centaurus-Lupus (UCL), and Lower Centaurus-Crux (LCC) subgroups of Scorpius-Centaurus (Sco-Cen), the nearest OB association. Our parent sample is the kinematically selected Hipparcos sample of de Zeeuw et al., restricted to the 138 F-type members. We have obtained classification-resolution optical spectra and have also determined the spectroscopic accretion disk fraction. With Hipparcos and 2MASS photometry, we estimate the reddening and extinction for each star and place the candidate members on a theoretical H-R diagram. For each subgroup we construct empirical isochrones and compare to published evolutionary tracks. We find that (1) our empirical isochrones are consistent with the previously published age-rank of the Sco-Cen subgroups; (2) subgroups LCC and UCL appear to reach the main-sequence turn-on at spectral types {approx}F4 and {approx}F2, respectively. An analysis of the A-type stars shows US reaching the main sequence at about spectral type {approx}A3. (3) The median ages for the pre-main-sequence members of UCL and LCC are 16 Myr and 17 Myr, respectively, in agreement with previous studies, however we find that (4) Upper Sco is much older than previously thought. The luminosities of the F-type stars in US are typically a factor of {approx}2.5 less luminous than predicted for a 5 Myr old population for four sets of evolutionary tracks. We re-examine the evolutionary state and isochronal ages for the B-, A-, and G-type Upper Sco members, as well as the evolved M supergiant Antares, and estimate a revised mean age for Upper Sco of 11 {+-} 1 {+-} 2 Myr (statistical, systematic). Using radial velocities and Hipparcos parallaxes we calculate a lower limit on the kinematic expansion age for Upper Sco of >10.5 Myr (99% confidence). However, the data are statistically consistent with no expansion. We reevaluate the inferred masses for the known

  4. The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role

    International Nuclear Information System (INIS)

    Krishna, S. Sri; Aravind, L.; Bakolitsa, Constantina; Caruthers, Jonathan; Carlton, Dennis; Miller, Mitchell D.; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L; Chiu, Hsiu-Ju; Clayton, Thomas; Deller, Marc C.; Duan, Lian; Feuerhelm, Julie; Grant, Joanna C.; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Kumar, Abhinav; Marciano, David; McMullan, Daniel; Morse, Andrew T.; Nigoghossian, Edward; Okach, Linda; Reyes, Ron; Rife, Christopher L.; Bedem, Henry van den; Weekes, Dana; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Elsliger, Marc-André; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A.

    2010-01-01

    The crystal structure of SSO2064, the first structural representative of Pfam family PF01796 (DUF35), reveals a two-domain architecture comprising an N-terminal zinc-ribbon domain and a C-terminal OB-fold domain. Analysis of the domain architecture, operon organization and bacterial orthologs combined with the structural features of SSO2064 suggests a role involving acyl-CoA binding for this family of proteins. SSO2064 is the first structural representative of PF01796 (DUF35), a large prokaryotic family with a wide phylogenetic distribution. The structure reveals a novel two-domain architecture comprising an N-terminal, rubredoxin-like, zinc ribbon and a C-terminal, oligonucleotide/oligosaccharide-binding (OB) fold domain. Additional N-terminal helical segments may be involved in protein–protein interactions. Domain architectures, genomic context analysis and functional evidence from certain bacterial representatives of this family suggest that these proteins form a novel fatty-acid-binding component that is involved in the biosynthesis of lipids and polyketide antibiotics and that they possibly function as acyl-CoA-binding proteins. This structure has led to a re-evaluation of the DUF35 family, which has now been split into two entries in the latest Pfam release (v.24.0)

  5. RPA-1 from Leishmania amazonensis (LaRPA-1) structurally differs from other eukaryote RPA-1 and interacts with telomeric DNA via its N-terminal OB-fold domain.

    Science.gov (United States)

    Pavani, R S; Fernandes, C; Perez, A M; Vasconcelos, E J R; Siqueira-Neto, J L; Fontes, M R; Cano, M I N

    2014-12-20

    Replication protein A-1 (RPA-1) is a single-stranded DNA-binding protein involved in DNA metabolism. We previously demonstrated the interaction between LaRPA-1 and telomeric DNA. Here, we expressed and purified truncated mutants of LaRPA-1 and used circular dichroism measurements and molecular dynamics simulations to demonstrate that the tertiary structure of LaRPA-1 differs from human and yeast RPA-1. LaRPA-1 interacts with telomeric ssDNA via its N-terminal OB-fold domain, whereas RPA from higher eukaryotes show different binding modes to ssDNA. Our results show that LaRPA-1 is evolutionary distinct from other RPA-1 proteins and can potentially be used for targeting trypanosomatid telomeres. Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

  6. Concentration urinaire de bisphénol A et obésité chez les adultes : résultats de l’Enquête canadienne sur les mesures de la santé

    Directory of Open Access Journals (Sweden)

    Minh T. Do

    2017-01-01

    Full Text Available Introduction : Des études chez l’animal ont révélé que l’exposition au bisphénol A (BPA affecte le métabolisme des lipides et favorise la prise de poids. Des études épidémiologiques récentes appuient aussi l’existence d’un lien entre le BPA et l’obésité chez l’humain, mais la plupart d’entre elles se limitent à une seule mesure de l’adiposité ou ne tiennent pas compte des facteurs de confusion alimentaires possibles. Cette étude vise à examiner les associations entre les concentrations urinaires de BPA et les mesures de l’adiposité dans un échantillon national représentatif des adultes canadiens. Méthodologie : Nous avons réalisé des analyses à l’aide de données de biosurveillance et de données anthropométriques mesurées directement auprès de 4 733 adultes de 18 à 79 ans dans le cadre de l’Enquête canadienne sur les mesures de la santé (2007-2011. Nous avons utilisé des modèles de régression logistique multinomiale et binaire pour estimer les associations entre, d’une part, les concentrations urinaires de BPA et, d’autre part, les diverses catégories d’indice de masse corporelle (IMC (embonpoint par opposition à poids insuffisant ou normal; obésité par opposition à poids insuffisant ou normal et un tour de taille élevé (102 cm ou plus pour les hommes; 88 cm ou plus pour les femmes en tenant compte des facteurs de confusion possibles. Des analyses de régression linéaire ont aussi été effectuées pour évaluer les associations entre les concentrations urinaires de BPA et des mesures de l’IMC et du tour de taille. Résultats : On a pu associer positivement la concentration urinaire de BPA et l’obésité (définie par l’IMC. Le rapport de cotes s’est situé à 1,54 (intervalle de confiance [IC] à 95 % : 1,002 à 2,37 dans le quartile de BPA le plus élevé par rapport au plus bas (test de tendance, p = 0,041. La concentration urinaire de BPA n’a pas été associ

  7. Late Paleozoic closure of the Ob-Zaisan Ocean along the Irtysh/Chara shear zone and implications for arc amalgamation and oroclinal bending in the western Central Asian Orogenic Belt

    Science.gov (United States)

    Li, Pengfei; Sun, Min; Rosenbaum, Gideon

    2016-04-01

    The Irtysh/Chara Shear Zone is one of the largest strike-slip systems in the Central Asian Orogenic Belt (CAOB). It records collisional processes of the peri-Siberian orogenic system with the West Junggar-Kazakhstan-Tianshan orogenic system following the closure of the Ob-Zaisan Ocean, but the exact timing of these events remains enigmatic. We conducted detailed structural analysis along the Irtysh Shear Zone (NW China), which together with new geochronological data allows us to reconstruct the tectonic evolution during the final closure of the Ob-Zaisan Ocean. Our results showed that subduction-accretion processes lasted at least until the Late Carboniferous in the Chinese Altai and the East/West Junggar. The subsequent arc amalgamation is characterized by a cycle of crustal thickening, orogenic collapse and transpressional thickening. On a larger scale, the West Junggar- Kazakhstan -Tianshan orogenic system defines a U-shape oroclinal structure (e.g. Xiao et al., 2010). A major phase of oroclinal bending that involved ~110° rotation may have occurred during the Late Devonian to Early Carboniferous (Levashova et al., 2012). Previous authors have linked oroclinal bending with the late Paleozoic amalgamation of the western CAOB, and proposed that a quasi-linear West Junggar- Kazakhstan -Tianshan orogenic system was buckled during the convergence of the Siberian and Tarim cratons following the closure of the Ob-Zaisan Ocean (in the north) and the South Tianshan Ocean (in the south) (e.g. Abrajevitch et al., 2008). This model, however, is not supported by our new data that constrain the closure of the Ob-Zaisan Ocean to the Late Carboniferous. Alternatively, we propose that oroclinal bending may have involved two phases of bending, with the ~110° rotation in the Late Devonian to Early Carboniferous possibly associated with trench retreat. Further tightening may have occurred in response to the convergence of the Siberian and Tarim cratons during the Late

  8. The phenomenon of phase separated in Na2O-B2O3-SiO2, Na2O-SiO2-P2O5 glasses

    International Nuclear Information System (INIS)

    Procyk, B.; Bieniarz, P.; Plichta, E.; Pudelek, B.; Kucinski, G.; Staniewicz-Brudnik, B.

    1997-01-01

    During the thermal treatment, the phenomenon of phase separation has been observed in the some glasses. The glass has became opaque, due to the opalescence of phase separated. Investigations of the phenomenon of phase separation were conducted using the basic systems: Na 2 O-B 2 O 3 -SiO 2 , Na 2 O-SiO 2 -P 2 O 5 and theirs modifications. The occurrence of binodal and spinodal phase decomposition was observed by TEM. The phase separation inhomogeneities have drop-like character and with higher concentration shows a tendency for coalescence. The influence of the chemical composition, temperature and time on the phenomenon of phase separation in the investigated glasses has been defined. (author)

  9. Nové poznatky ze studia mineralogie, fluidních inkluzí a izotopů síry v rudách skarnového ložiska v Obřím dole

    Czech Academy of Sciences Publication Activity Database

    Pašava, J.; Veselovský, F.; Dobeš, P.; Haluzová, Eva; Ackerman, Lukáš; Tásler, R.

    2016-01-01

    Roč. 49, č. 1 (2016), s. 47-52 ISSN 0514-8057 R&D Projects: GA ČR GA13-15390S Institutional support: RVO:67985831 Keywords : Obří důl skarn-type deposit * mineralogy * fluid inclusions * sulfur isotopes Subject RIV: DB - Geology ; Mineralogy

  10. Effect of Mixed Glass Former on Ionic Conductivity of Silver Boro Tungstate glass system x[0.75AgI:0.25AgCl]: (1-x) [Ag2O-{B2O3:WO3}

    Science.gov (United States)

    Dehariya, Harsha; Kumar, R.; Polu, A. R.

    2012-05-01

    The idea to explore new 'Superionic Electrolytes', "Fast ionic conductors" is due to their tremendous potential applications in solid state electrochemical devices viz. solid state batteries, fuel cells, sensors, super capacitors. Superionic glasses have attracted great deal of attention due to their several advantageous over their crystalline counterparts such as high ionic conductivity, easy preparation, wide selection of compositions, isotropic properties and high stability etc [4-7]. Large numbers of silver ion based glasses have been reported in the literature for the glassy system of AgI:Ag2O: MxOy (MxOy = B2O3, SiO2, P2O5, GeO2, V2O5, As2O5, CrO3, SeO2, MoO3 & TeO3 etc many of them shows high silver ion conductivity [8]. Ion transport behavior of Silver Boro Tungstate glass system x[0.75AgI:0.25AgCl]: (1-x) [Ag2O{B2O3:WO3}], where 0 <= x <= 1 in molar wt% prepared by melt quench technique were reported. The new host [0.75AgI:0.25AgCl] was used as a better alternate in place of conventional host salt AgI. Conductivity measurement were carried out on this glass system as a function of frequency from 50 Hz to 5 MHz, over a temperature range of 27°C to 200°C, for different compositions by Impedance spectroscopy. The composition 0.7[0.75AgI:0.25AgCl]: 0.3[Ag2O{B2O3:WO3}] shows the highest conductivity of the order of σrt ~ 2.76 × 10-2 S/cm, referred to as the Optimum Conducting Composition (OCC). The enhancement in the conductivity has been obtained by mixed former effect. XRD result shows that the system is completely amorphous. Temperature dependence of conductivity of all compositions were studied & reported. Activation energies (Ea) were also evaluated from the slope of .Log(σ) vs 1000/T, Arrhenius plots.

  11. Effect of Mixed Glass Former on Ionic Conductivity of Silver Boron Tungstate glass system x[0.75AgI:0.25AgCl]: (1-x) [Ag2O-(B2O3:WO3)

    International Nuclear Information System (INIS)

    Dehariya, Harsha; Kumar, R; Polu, A R

    2012-01-01

    The idea to explore new 'Superionic Electrolytes', 'Fast ionic conductors' is due to their tremendous potential applications in solid state electrochemical devices viz. solid state batteries, fuel cells, sensors, super capacitors. Superionic glasses have attracted great deal of attention due to their several advantageous over their crystalline counterparts such as high ionic conductivity, easy preparation, wide selection of compositions, isotropic properties and high stability etc [4-7]. Large numbers of silver ion based glasses have been reported in the literature for the glassy system of AgI:Ag2O: MxOy (MxOy = B2O3, SiO2, P2O5, GeO2, V2O5, As2O5, CrO3, SeO2, MoO3 and TeO3 etc many of them shows high silver ion conductivity [8]. Ion transport behavior of Silver Boro Tungstate glass system x[0.75AgI:0.25AgCl]: (1-x) [Ag2O(B2O3:WO3)], where 0 ≤ x ≤ 1 in molar wt% prepared by melt quench technique were reported. The new host [0.75AgI:0.25AgCl] was used as a better alternate in place of conventional host salt AgI. Conductivity measurement were carried out on this glass system as a function of frequency from 50 Hz to 5 MHz, over a temperature range of 27 C to 200 C, for different compositions by Impedance spectroscopy. The composition 0.7[0.75AgI:0.25AgCl]: 0.3[Ag2O(B2O3:WO3)] shows the highest conductivity of the order of σrt ∼ 2.76x10-2 S/cm, referred to as the Optimum Conducting Composition (OCC). The enhancement in the conductivity has been obtained by mixed former effect. XRD result shows that the system is completely amorphous. Temperature dependence of conductivity of all compositions were studied and reported. Activation energies (Ea) were also evaluated from the slope of .Log(σ) vs 1000/T, Arrhenius plots.

  12. Hardness properties and microscopic investigation of crack- crystal interaction in SiO(2)-MgO-Al(2)O(3)-K(2)O-B(2)O(3)-F glass ceramic system.

    Science.gov (United States)

    Roy, Shibayan; Basu, Bikramjit

    2010-01-01

    In view of the potential engineering applications requiring machinability and wear resistance, the present work focuses to evaluate hardness property and to understand the damage behavior of some selected glass-ceramics having different crystal morphologies with SiO(2)-MgO-Al(2)O(3)-K(2)O-B(2)O(3)-F composition, using static micro-indentation tests as well as dynamic scratch tests, respectively. Vickers hardness of up to 5.5 GPa has been measured in glass-ceramics containing plate like mica crystals. Scratch tests at a high load of 50 Nin artificial saliva were carried out in order to simulate the crack-microstructure interaction during real-time abrasion wear and machining operation. The experimental observations indicate that the novel "spherulitic-dendritic shaped "crystals, similar to the plate like crystals, have the potential to hinder the scratching induced crack propagation. In particular, such potential of the 'spherulitic-dendritic' crystals become more effective due to the larger interfacial area with the glass matrix as well as the dendritic structure of each mica plate, which helps in crack deflection and crack blunting, to a larger extent.While modest damage tolerant behavior is observed in case of 'spherulitic-dendritic' crystal containing material, severe brittle fracture of plate like crystals were noted, when both were scratched at 50 N load.

  13. Rozwój morfologiczny i sprawności specjalnej 13 – letnich chłopców trenujących piłkę nożną w Klubie Sportowym „Pogoń” Łobżenica = Morphological and a special efficiency development 13-years old boys soccer summer training in a sports club "Chase" Łobżenica

    Directory of Open Access Journals (Sweden)

    Mariusz Klimczyk

    2016-07-01

      Słowa kluczowe: test, sprawność fizyczna, sprawność specjalna, piłka nożna, rozwój morfologiczny.   Abstract The aim of the work was to identify the morphological development and efficiency of a special 13-years old boys soccer summer training in "Chasing" Łobżenica. The test group consisted of 17 players who attended training classes three times a week (training unit was 60 minutes. In addition, participated four times a week in physical education classes in school. The study took place in two periods: the first in August 2015, and the second in April 2016. Measured weight and height of the body and was carried out "technical performance for boys aged 10-14 years old," George Talaga. There was progress and large diversity of subjects. Correlation between morphological features, and obtained points in the test performance special was released to moderate the relationship between these characteristics. The work shows that when the young player does not attend regularly for training, no progression of their skills. It is therefore necessary to systematic monitoring by the skill level of students, and applying adjustments in the training plan to in the future make it easier to eliminate this phenomenon. Keywords: test, physical fitness, the efficiency of the special, football, morphological development.

  14. Legislation and Identification of Irradiated Foodstuffs; Reglementation et Identification des Denrees Irradiees; Zakonodatel'stvo po obluchennym pishchevym produktam i metody ikh identifikatsii; Legislacion y'Identificacion de los Alimentos Irradiados

    Energy Technology Data Exchange (ETDEWEB)

    Lafontaine, A. [Institut d' Hygiene et d' Epidemiologie, Ministere de la Sante Publique, Bruxelles (Belgium)

    1966-11-15

    Originally of purely military importance, the irradiation of food commodities is nowadays of increasing interest in the civilian sector, and commodities so treated will shortly be marketed. Protection of the health of the consumer should be the main element in arguments for and against this practice. In view of the uncertainties which make it difficult to take up a definite attitude to the problem as a whole, Belgium has preferred to adopt the principle of prohibition, with the possibility of progressively departing from this principle as further knowledge becomes available. Article 64.1 (b) and (c) of the Royal Decree of 28 February 1963 prohibits the addition of radioactive substances to foodstuffs and the treatment of foodstuffs by ionizing radiations. Article 65 (a) and (b) actually already provides for rescindment of prohibition on condition that the addition or treatment is performed for research purposes and that a specific licence has been granted by the Ministry of Public Health. The import, possession or transport of foodstuffs to which radioactive substances have been added or which have been treated by ionizing radiations are also prohibited under Article 64.2. Similar prohibitions are applied in regard to two products of a somewhat similar nature to foodstuffs, i.e. medicaments and medical supplies which have been treated by ionizing radiations; with a view to progressive liberalization, however, considerable easing of the regulations is proposed as far as medical supplies are concerned. In spite of the lack of conviction in certain scientific circles regarding the wholesomeness of irradiated foods, it is likely that a number of processes will shortly be accepted. A number of countries have already authorized consumption of various irradiated foods and it is to be assumed that national barriers will be overcome by commercial ties. At the same time, some control is essential to ensure that the authorized processes are not applied to foods for which they have not been specified and to check that the permissible doses are not exceeded. Identification of irradiated foods and, as appropriate, determination of the doses employed therefor, constitute a national and an International problem. The problem can be approached in numerous ways, as shown by the following list of possible methods: measurement of the paramagnetic state of the atom, electrophoresis, measurement of redox potential, polarography, spectrophotometry, chromatography, colorimetry, microscopic examination of tissues, immunological changes, microbiology, changes in the packing material, and changes in organoleptic characteristics. The most promising methods so far appear to be spectrophotometry, chromatography, electrophoresis, changes in redox potential and determination of various oxidation products. Considerable research remains to be done and this must take account of the following requirements: - the method must be as specific as possible; it must be qualitative and if possible quantitative; - results must be obtained from parallel tests on irradiated products, untreated products, and products preserved by other processes; - the tests must be protracted, covering a period at least as long as that for which the foods are kept before before consumption, in order to ascertain whether the changes observed persist, become more pronounced, or disappear. - finally, the method must be capable of as near universal application as possible, account to be taken of the range of foods which can be irradiated, the types of irradiation and the doses employed. (author) [French] D'un interet purement militaire au debut, les recherches sur l'irradiation des denrees alimentaires ont progressivement interesse le domaine civil et nous sommes au seuil de la commercialisation de tels produits: la protection de la sante du consommateur doit etre l'element principal du faisceau d'arguments pour ou contre une telle pratique. En raison des incertitudes qui empechent de formuler un jugement definitif sur l'ensemble du probleme, la Belgique a prefere recourir au principe de l'interdiction, quitte a envisager des derogations progressives en fonction du progres des connaissances. L'arrete royal du 28 fevrier 1963, en son article 64,1 alineas b et c, interdit d'ajouter des substances radioactives aux denrees alimentaires ou de traiter celles-ci par les radiations ionisantes. Deja actuellement l'article 65, alineas a et b, prevoit une derogation a condition que l'incorporation ou le traitement soient effectue a des fins de recherches et qu'une autorisation specifique ait ete accordee par le Ministere de la Sante publique. L'Importation, la detention et le transport de denrees auxquelles des substances radioactives sont ajoutees ou traitees par des radiations ionisantes sont egalement interdits en vertu de l'article 64.2. Des dispositions analogues d'interdiction sont prises a l'egard de deux produits proches des denrees, les medicaments et le materiel medical traites par les radiations ionisantes; toutefois, dans le sens d'une liberalisation progressive, un serieux assouplissement est propose en ce qui concerne le materiel medical. Malgre les incertitudes qui continuent a regner dans certains milieux scientifiques quant a la salubrite des aliments irradies, il est vraisemblable que certains procedes ont des chances d'etre admis a plus ou moins breve echeance. Quelques pays ont d'ailleurs deja autorise la consommation de plusieurs aliments irradies et il est a prevoir que le circuit commercial tendra a franchir les frontieres nationales. Par ailleurs, il est indispensable de pduvoir s'assurer que les procedes autorises n'ont pas ete indument appliques a des denrees pour lesquelles ils n'etaient pas prevus et que les doses tolerees ont ete respectees. Le probleme de 1'identification des produits irradies et de la connaissance eventuelle de la dose utilisee pour l'irradiation se pose par consequent sur le plan national et sur le plan international.Un inventaire des methodes qu'on peut envisager montre la multiplicite des modes d'approche de la question: mesure de l'etat paramagnetique de l'atome, electrophorese, mesure du potentiel d'oxydoreduction, polarographie, spectrophotometrie, chromatographie, colorimetrie, examen microscopique des tissus, modifications immunologiques, microbiologie, modification du materiel d'emballage et modification des caracteres organoleptiques. Jusqu'a present, la spectrophotometrie, la chromatographie, l'electrophorese, les modifications du potentiel d'oxydo-reduction et le dosage de certains produits d'oxydation paraissent les plus prometteurs. Des recherches importantes restent necessaires; elles doivent tenir compte de divers imperatifs: - la methode doit etre aussi specifique que possible, qualitative et, si possible, quantitative; - les resultats doivent provenir d'essais menes parallelement sur des produits irradies, sur des produits non traites et sur des produits conserves par d'autres procedes; - les essais doivent etre etendus dans le temps au moins aussi longtemps que dure la conservation habituelle des denrees avant leur consommation pour se rendre compte si les modifications eventuellement observees se maintiennent, s'accentuent ou disparaissent; - enfin, la methode doit etre aussi universelle que possible, compte tenu de la gamme de denrees pouvant etre irradiees, des modes d'irradiation et des doses utilisees. (author) [Spanish] Las investigaciones sobre irradiacion de alimentos, que al principio tenian un interes puramente militar, han llegado a interesar al sector civil; pronto se procedera a la comercializacion de esos productos irradiados: el principal elemento del conjunto de argumentos aducidos en pro o en contra de tal procedimiento debe ser la proteccion de la salud del consumidor. En vista de las incognitas que impiden formular un juicio definitivo sobre el problema considerado en su totalidad. Belgica ha preferido adoptar el principio de la prohibicion, sin perjuicio de derogaciones progresivas a medida que vayan progresando los conocimientos. En los apartados b y c del articulo 64.1 del real decreto de 28 de febrero de 1963 se prohibe anadir sustancias radiactivas a los productos alimenticios o tratarlos con radiaciones ionizantes. Ya en la actualidad, el articulo 65 (apartados a y b) preve una excepcion siempre que la incorporacion o el tratamiento se efectuen con fines de investigacion y con una autorizacion explicita del Ministerio de Sanidad Publica. El articulo 64.2 prohibe tambien la importacion, retencion y transporte de productos alimenticios a los que se hayan anadido sustancias radiactivas o que hayan sido tratados con radiaciones ionizantes. Se han adoptado disposiciones prohibitivas analogas con respecto a dos productos afines a los articulos alimenticios: los medicamentos y los suministros medicos tratados con radiaciones ionizantes. No obstante, con miras a una liberalizacion progresiva, se propone una gran flexibilidad en lo que respecta a los suministros medicos. Pese a la incertidumbre que continua existiendo en ciertos medios cientificos en cuanto a la salubridad de los alimentos irradiados, es probable que ciertos procedimientos sean admitidos en plazo mas o menos breve. Algunos paises han autorizado ya el consumo de diferentes alimentos irradiados y cabe prever que el circuito comercial tendera a rebasar las fronteras nacionales. Por otra parte, es indispensable tener la posibilidad de verificar que los procedimienros autorizados no se aplican indebidamente a articulos para los que no han sido previstos y que se respetan las dosis establecidas. Es decir, se plantea, en el plano nacional y en el internacional, el problema de la identificacion de los productos irradiados y, eventualmente, el de la comprobacion de la dosis de radiacion administrada. El inventario de los metodos que se podrian aplicar muestra la variedad de las maneras de abordar la cuestion: medicion del estado paramagnetico del atomo, electroforesis, medicion del potencial de oxidorreduccion, polarografia, espectrofotometrin, cromatografia, colorimetria, examen microscopico de los tejidos, modificaciones inmunologicas, microbiologia, modificacion del material de embalaje y modificacion de los caracteres organolepticos. Hasta ahora, la espectrometria, la cromatografia, la electroforesis, las modificaciones del potencial de oxidorreduccion y la valoracion de ciertos productos de oxidacion parecen los metodos mas prometedores. Continua siendo necesario efectuar algunas investigaciones importantes en las que se han de tener presentes diferentes imperativos: - el metodo debe ser lo mas especifico posible-cualitativo, y, si es posible, cuantitativo; - los resultados deben provenir de ensayos realizados paralelamente con productos irradiados, con productos 110 irradiados y con productos conservados por otros procedimientos; - los ensayos deben extenderse a todo el tiempo que dure la conservacion habitual de los productos antes de su consumo para poder comprobar si las modificaciones que eventualmente se observen se mantienen, se acentuan o desaparecen; - por ultimo, el metodo debe ser lo mas universal posible, teniendo en cuenta la variedad de productos que pueden irradiarse, las modalidades de la irradiacion y las dosis administradas. (author) [Russian] Nauchnye issledovanija v oblasti obluchenija pishhevyh produktov, predstavljavshie snachala interes s chisto voennoj tochki zrenija, postepenno ohvatyvajut i grazhdanskuju oblast', j my nahodimsja nakanune takogo polozhenija, kogda jeti produkty priobretajut kommercheskoe znachenie. Ohrana zdorov'ja potrebitelja dolzhna byt' glavnym argumentom takoj praktiki. Vvidu imejushhihsja nejasnostej, meshajushhih sostavit' okonchatel'noe mnenie po probleme v celom, Bel'gija predpochitaet pribegnut' k principu zapreshhenija, izbegat' postepennyh otstuplenij v zavisimosti ot progressa poznanij. Korolevskim postanovleniem ot 28 fevralja 1963 goda, stat'ja 64,1 podpunkty b i s, zapreshhaetsja primenjat' radioaktivnye veshhestva k pishhevym produktam ili obrabatyvat' ih pri pomoshhi ionizirujushhih izluchenij. Uzhe v nastojashhee vremja stat'ja 65, podpunkty ai', predusmatrivaet otstuplenie ot vysheukazannogo pravila pri uslovii, chto primenenie takih veshhestv ili obrabotka imi budut osushhestvljat'sja v issledovatel'skih celjah i pri nalichii special'nogo razreshenija Ministerstva zdravoohranenija. Vvoz, hranenie i perevozka pishhevyh produktov, kotorye podvergalis' obrabotke radioaktivnymi veshhestvami, takzhe zapreshheny v silu stat'i 64,2. Analogichnye polozhenija prinjaty v otnoshenii medikamentov i medicinskogo oborudovanija, obrabatyvaemyh pri pomoshhi ionizirujushhih izluchenij. Tem ne menee v porjadke postepennogo predostavlenija bol'shoj svobody dopuskaetsja opredelennaja gibkost' v otnoshenii medicinskogo oborudovanija. Nesmotrja na to, chto nekotorye nauchnye krugi prodolzhajut somnevat'sja otnositel'no bezvrednosti obluchennyh pishhevyh produktov, predstavljaetsja verojatnym v nedalekom budushhem ispol'zovat' nekotorye metody. Nekotorye strany k tomu zhe uzhe dali razre- . shenie na potreblenie nekotoryh vidov obluchennyh pishhevyh produktov i mozhno predvidet', chto ih prodazha vyjdet za ramki nacional'nyh granic. Krome togo, neobhodimo obespechit' .takoe polozhenie, chtoby metody, kotorye byli odobreny, ne primenjalis' k produktam, dlja kotoryh oni ne predusmotreny, i chtoby sobljudalis' dopustimye dozy obluchenija. Takim obrazom, v nacional'nom i mezhdunarodnom plane voznikaet problema identifikacii obluchennyh produktov i vozmozhnogo opredelenija dozy obluchenija. Rassmotrenie perechnja vozmozhnyh metodov ukazyvaet na mnozhestvo sposobov podhoda k resheniju jetogo voprosa: izmerenie paramagnitnogo sostojanija atoma, jelektroforez, izmerenie potenciala okislitel'no-vosstanovitel'nogo processa, polarografija, spektro- fotometrija, hromatografija, kalorimetrija, mikroskopicheskoe izuchenie tkanej, immunologicheskie izmenenija, mikrobiologija, izmenenie upakovochnogo materiala i izmenenie organolepticheskih svojstv. Do nastojashhego vremeni spektrofotometrija, hromatografija, jelektroforez, izmenenija potenciala okislitel'no-vosstanovitel'nogo processa i dozirovka nekotoryh okislov, po-vidimomu, javljajutsja naibolee obeshhajushhimi. Neobhodimo provedenie vazhnyh issledovanij s uchetom razlichnyh trebovanij: - metod dolzhen byt' po vozmozhnosti specificheskim, kachestvennym i, esli vozmozhno, kolichestvennym; - rezul'taty dolzhny vytekat' iz issledovanij, parallel'no vedushhihsja s obluchennymi produktami, s neobrabotannymi produktami i s produktami, sohranjaemymi drugimi sposobami; - issledovanija dolzhny provodit'sja v techenie takogo vremeni, kotoroe vozmozhno dlja obychnogo hranenija pishhevyh produktov do ih potreblenija, s tem, chtoby vyjasnit', sohranjajutsja, usilivajutsja ili ischezajut nabljudaemye v izvestnyh sluchajah modifikacii; - nakonec, metod dolzhen byt' po vozmozhnosti universal'nym, uchityvaja bol'shoe kolichestvo produktov, kotorye mogut byt' oblucheny, sposoby obluchenija i ispol'zuemye dozy. (author)

  15. Rozum občanství

    Czech Academy of Sciences Publication Activity Database

    Kuneš, Jan

    2004-01-01

    Roč. 15, č. 26 (2004), 1a-3 ISSN 1210-0021 Institutional research plan: CEZ:AV0Z9009908 Keywords : Jean Jacques Rousseau * Immanuel Kant * Georg Wilhelm Friedrich Subject RIV: AA - Philosophy ; Religion

  16. Refleksija ob pojmu romantika v glasbi

    Directory of Open Access Journals (Sweden)

    Katarina Bogunović Hočevar

    2007-12-01

    Full Text Available Zdi se, da je raba pojma romantična glasba ali glasbena romantika v vsakodnevni govorici že tako močno zakoreninjena in samoumevna, da se ponovno preverjanje pomena na videz kaže kot nepotrebno. Pretres nekaterih razprav sodobnega muzikološkega diskurza pa kaže povsem drugačno podobo: opredelitve pojma in pristopi pri tem so si tako zelo različni, da se zdi kakršna koli dokončna definicija pojma nemogoča. Toda iskanja bistva in legitimnih vzrokov za nastanek romantike v glasbi ne smemo omejiti zgolj na muzikološka dognanja, temveč zahteva poznavanje duhovnozgodovinske antropologije novoveškega človeka.

  17. R-ES-ONANCE--IOct-ob-er

    Indian Academy of Sciences (India)

    are to a major extent descriptive. Biochemis- ... This is ironic, since research in biophysics in laboratories and .... inside a live celL Analysis of function of a biomolecule and its ... biophysics research scene too, where the gap is even more.

  18. RESONANCE--IO--ct-ob-er

    Indian Academy of Sciences (India)

    (masonry or RC) of partial height built to fit a window over the remaining height. The adjacent columns behave as short columns due to presence of these walls. In many cases, other columns in the same storey are of regular height, as there are no walls adjoining them. When the floor slab moves horizontally during an.

  19. The state ob the college students health

    Directory of Open Access Journals (Sweden)

    Vovchenko I.I.

    2010-01-01

    Full Text Available The paper focuses on the problem of health worsening among people suffering from many different diseases. Young people make up risk group. The article highlights the health conditions of pedagogical and medical college students. Medical groups have been determined as well as the increasing tendency within special medical group.

  20. [Comparing the Application of Hema-Obs RSS to 250 Pregnancies from Obstetrics/Hematology Consultation in Centro Hospitalar São João, Portugal with the Application of Galit Sarig RSS to 90 Pregnancies from Rambam Health Care Campus, Israel].

    Science.gov (United States)

    Salselas, Ana; Pestana, Inês; Bischoff, Francisco; Guimarães, Mariana; Andrade, Joaquim Aguiar

    2015-01-01

    Pregnant women with thromboembolic diseases, previous thrombotic episodes or thrombophilia family history were supervised in a multidisciplinary Obstetrics/ Hematology consultation in Centro Hospitalar São João EPE, Porto, Portugal. For the evaluation and medication of these women, a risk stratification scale was used. The aim of this study was to validate a Risk Stratification Scale and thromboprophylaxis protocol by means of comparing it with a similar scale, developed and published by Sarig. We have compared: The distribution, by risk groups, obtained through the application of the two scales on pregnant women followed at Centro Hospitalar São João, Porto, Portugal, consultation; the sensibility and specificity for each one of the scales (DeLong scale, applied to Receiver Operating Characteristic) curves; the outcomes in pregnancies followed in Hospital São João, Porto, PortugalResults: According to our Hema-Obs risk stratification scale, 29% were allocated to low-risk, 47% to high-risk and 24% to very-high-risk groups. According to Galit Sarig risk stratification scale, 24% were considered low-risk, 53% moderate, 16% high-risk and 7% as very high-risk group. In our study we observed 9% of spontaneous abortions, in comparison with 18% in the Galit Sarig cohort. From the application of Receiver Operating Characteristic curve to both risk stratification scales, the results of the calculated areas were 58,8% to our Hema-Obs risk stratification scale and 38,7% to Galit Sarig risk stratification scale, with a Delong test significancie of p = 0.0006. We concluded that Hema-Obs risk stratification scale is an effective support for clinical monitoring of therapeutic strategies.

  1. 医用OB胶联合几丁聚糖-胶原导管修复兔面神经损伤的实验研究%Facial nerve repair with OB glue and chitosan-collagen conduit:An experimental study in rabbits

    Institute of Scientific and Technical Information of China (English)

    屈振宇; 曲卫国; 马卫东; 曲晓娟; 张璐; 裘罡

    2011-01-01

    PORFUSE: To explore the effect of using OB glue combined with chitosan-collagen conduit to repair rabbit facial nerve injury. METHODS: Thirty Chinese rabbits were divided into 3 groups randomly. The injury in right facial nerve of rabbits was repaired using: nerve autografts (group I ), OB glue (group Ⅱ), and OB glue with chitosan-collagen conduit (group Ⅲ) in 3 groups,respectively. Gross observation, electrophysiological study, histological study and image analysis were performed 16 weeks postoperatively .The data was subjected to one-way ANOVA with SPSS 17.0 software package to evaluate nerve regeneration. RESULTS: Nerve regeneration was obvious observed 16 weeks postoperatively and could resist certain tension . Chitosan-collagen conduit was degraded 16 weeks postoperatively and restrained the formation of neuroma. The tissue adhesions in group I and group Ⅱ was more severe than in group Ⅲ. The recovery of neuro-muscular function was good in 3 groups,and motor nerve action potential was not significantly different among 3 groups (P>0.05),but the compound muscle action potential (CMAP) of regenerated nerve was significantly higher in group Ⅲ than in group Ⅱ (P0.05).Different degree of hyperplasia of fibrous connective tissue and new formed capillaries was noted ,nrnl inflammatory cell infiltration was also found in 3 groups. The effect of chitosan - collagen ennduil in group Ⅲ was observed both under low magnification of microscope and high nullification with Gomori's silver staining.The recovery rale of myelinated fibrr cross section diameler in 3 groups was different (p0.05 ). CONCLUSION: Chitnsan-collagRn conduit has excellent biocompatibilty. It can be OB glue to repair nerves injuries with good results. Supported by Dalian Outstanding Science and Technology Talents Fund (2006J23JH016).%目的:探讨医用OB胶联合几丁聚糖--胶原导管修复兔面神经损伤的效果.方法:30只健康中国大耳白兔随机分为3组,

  2. Le surpoids, l’obésité et le contrôle glycémique chez les diabétiques du centre de référence provincial de diabète (CRD), Kénitra, Maroc

    Science.gov (United States)

    Lotfi, Zeghari; Aboussaleh, Youssef; Sbaibi, Rachid; Achouri, Imane; Benguedour, Rachid

    2017-01-01

    Introduction Le diabète est définit comme un trouble de l'assimilation, de l'utilisation et du stockage des sucres apportés par l'alimentation, sa prise en charge est assurée par le suivi du surpoids et l'obésité et le contrôle glycémique régulier. L'objectif de ce travail était l'étude du surpoids, l'obésité et le contrôle glycémique chez 2227 diabétiques de différent type (type 1, 2 et gestationnel), consultants le centre de référence provincial de diabète (CRD), Kénitra-Maroc. Méthodes L'étude s'est déroulée sur une période d'une année du mois janvier au mois décembre 2015, L'évaluation du surpoids et l'obésité a été effectuée par le calcul de l'Indice de Masse Corporelle (IMC=Poids/Taille2 (Kg/m2)), elles sont définit respectivement par IMC > 25 Kg/m2, et IMC > 30 Kg/m2, le poids et la taille ont été mesurés selon les recommandations de l'organisation mondiale de santé (OMS), Le contrôle glycémique a été effectué par l'analyse sanguine de l'Hémoglobine glycosylée et de la Glycémie à jeun. Les normes sont 7% pour l'Hémoglobine glycosylée et 0,70g/l à 1,10g/l pour la Glycémie à jeun. Résultats L'intervalle d'âges des patients est compris entre 8 mois et 80 ans, avec une dominance des diabétiques provenant du milieu urbain (74%) par rapport à ceux provenant du milieu rural (26%). Le surpoids touche l'ensemble de cette population. L'IMC moyen des femmes tends vers l'obésité (IMC≈30): (29,21 Kg/m2 ± 3,1) pour le diabète gestationnel et (29,15 Kg/m2 ± 3,2) pour le diabète de type 2. Les valeurs du contrôle glycémique sont supérieures aux normes: avec 8,5% ± 2,6 > 7% pour l'hémoglobine glycosylée et 1,5 g/l ± 1,3 > 1,10g/l pour la Glycémie à jeun. La différence entre les valeurs de l'hémoglobine glycosylée entre les hommes (8,5 7% ± 2,6) et les femmes (8,1% ± 2,3) n'est pas significative (P > 0,05), même chose pour la Glycémie capillaire à jeun: pour les hommes (1,44 g/l ± 1,1) et les

  3. R-ES-ONANCE--IO--ct-ob-er

    Indian Academy of Sciences (India)

    have a course based on this book as an integral part. I hope that they are out ... The first chapter in troduces the idea of infinite square ... finite groups of numbers via the operations of addition and ... elements which also gives a matching of the corresponding ... The scientific method is only as effective as the humans using it.

  4. Star formation within OB subgroups: Implosion by multiple sources

    International Nuclear Information System (INIS)

    Klein, R.I.; Sanford, M.T. III; Whitaker, R.W.

    1983-01-01

    We present the results of new detailed two-dimensional radiation-hydrodynamical calculations of the effects of radiation-driven shock waves from two O stars on inhomogeneities embedded in molecular clouds. The calculations indicate the neutral primordial clumps of gas with 84 M/sub sun/ can be highly compressed in 3 x 10 4 yr with density enhancements greater than 170 over ambient densities and 40 M/sub sun/ remaining. Inhomogeneities that are compressed in this manner by stars in the range O7--B0 survive ionization evaporation and may rapidly form new stars. Low-mass objects would not survive, and there would be a natural cutoff of low-mass and high-mass stars. We present a scenario for hierarchical radiation-driven implosion as a potential, new highly efficient mechanismfor star formation that may explain aspects of recent observations of new star formation in ultracompact H II regions

  5. Luminous carbon star in Canis Major OB1

    International Nuclear Information System (INIS)

    Herbst, W.; Racine, R.; Richer, H.B.

    1977-01-01

    The fact that W CMa illuminates a reflection nebula is used to argue that it is spatially associated with the CMa OBl/CMa Rl complex. An apparent cluster around the carbon star is found to consist primarly of field stars, although a few probable late B-type members of CMa OBl are identified. On the basis of its likely association with CMa OBl, a luminosity for W CMa is derived. The values M/sub v/ = -4.7 and M/sub bol/ = - 7.2 are found. It seems likely that the progenitor of W CMa was an O-type member of CMa OBl with a mass greater than 20 M/sub solar/ and a main-sequence lifetime less than 3 x 10 6 years

  6. EPOXI EARTH OBS - HRII CALIBRATED SPECTRA V2.0

    Data.gov (United States)

    National Aeronautics and Space Administration — This dataset contains calibrated, 1.05- to 4.8-micron spectra of Earth acquired by the High Resolution Infrared Spectrometer (HRII) during the EPOCh and Cruise 2...

  7. New preemptive scheduling for OBS networks considering cascaded wavelength conversion

    Science.gov (United States)

    Gao, Xingbo; Bassiouni, Mostafa A.; Li, Guifang

    2009-05-01

    In this paper we introduce a new preemptive scheduling technique for next generation optical burst-switched networks considering the impact of cascaded wavelength conversions. It has been shown that when optical bursts are transmitted all optically from source to destination, each wavelength conversion performed along the lightpath may cause certain signal-to-noise deterioration. If the distortion of the signal quality becomes significant enough, the receiver would not be able to recover the original data. Accordingly, subject to this practical impediment, we improve a recently proposed fair channel scheduling algorithm to deal with the fairness problem and aim at burst loss reduction simultaneously in optical burst switching. In our scheme, the dynamic priority associated with each burst is based on a constraint threshold and the number of already conducted wavelength conversions among other factors for this burst. When contention occurs, a new arriving superior burst may preempt another scheduled one according to their priorities. Extensive simulation results have shown that the proposed scheme further improves fairness and achieves burst loss reduction as well.

  8. Electronic Commerce -RE-SONANCE---IOct-ob-er

    Indian Academy of Sciences (India)

    and the emergence of a number of Internet Service Providers. (lSPs) who ..... may be a distributed client/server type system with each office being a client and the .... called denial of service in which a large number of frivolous enquiries are ...

  9. EPOXI EARTH OBS - MRI CALIBRATED IMAGES V2.0

    Data.gov (United States)

    National Aeronautics and Space Administration — This dataset contains calibrated, 750-nm filter images of Earth acquired by the Deep Impact Medium Resolution Visible CCD (MRI) during the EPOCh and Cruise 2 phases...

  10. Integrated geophysical interpretation of the Valhall 4C OBS survey

    Energy Technology Data Exchange (ETDEWEB)

    Thomsen, Leon A.; Barkved, Olav I; Mueller, Michael C.; Haggard, Bill W.; Kommedal, Jan H.; Rosland, Boerge O.

    1998-12-31

    This presentation gives a brief classic example of a North Sea reservoir which cannot be imaged by conventional P-wave techniques. In two-dimensional P-wave sections, extending across the crest of the structure, the top of the chalk reservoir is depressed in time, and has low amplitude and coherency so that even its identification is uncertain. The classical interpretation of these effects is that, over geologic time, gas has leaked from the reservoir into the overburden, in the zone above the reservoir. This gas, while present in uneconomic concentrations, has the effect of lowering seismic velocities and increasing seismic attenuation. Efficient methods of seismic surveying were used for oil prediction in the reservoir. 6 refs.

  11. Dropping Probability Reduction in OBS Networks: A Simple Approach

    KAUST Repository

    Elrasad, Amr; Rabia, Sherif; Mahmoud, Mohamed; Aly, Moustafa H.; Shihada, Basem

    2016-01-01

    by being adaptable to different offset-time and burst length distributions. We observed that applying a limited range of wavelength conversion, burst blocking probability is reduced by several orders of magnitudes and yields a better burst delivery ratio

  12. Electrophoresis in the analysis of natural and industrial ob ects

    International Nuclear Information System (INIS)

    Stepanov, A.V.; Korchemnaya, E.K.

    1979-01-01

    Given is a brief review on practical application of electrophoresis in the analysis of natural and industrial objects. Suggested are expressiVe methods of thorium, uranium and rare earth elements separation in minerals by electrophoresis. The possibility of quantitative determination of rare earth elements in meteorites by the method of electromigration is shown. By means of electrophoresis identified are forms of radioruthenium in a sea water. Shown is the electrophoresis application for reactor loop water analysis, for environment contamination study, for determination of some rare earth yield in reactions of uranium fission by heavy ions

  13. The distribution in luminosity of OB stars and evolutionary timescales

    International Nuclear Information System (INIS)

    Bisiacchi, F.; Carrasco, L.; Costero, R.; Firmani, C.; Rayo, J.F.

    1979-01-01

    The authors have obtained the observed fraction of supergiant (luminosity classes I and II), giant (III) and dwarf (IV-V) stars of spectral types B2 and earlier. The stellar sample used was formed with all the stars with bidimensional spectral classification listed in the Catalogue of Galactic O stars by Cruz-Gonzalez et al. (1974) , and unpublished compilation of BO and BO.5 stars by J. F. Rayo, and the B1-B2 stars listed by Morgan et at. (1955). The results are listed together with the total number of stars considered in each spectral interval. A prominent conclusion is drawn from the table: The fractions remain approximately constant all over the spectral range considered. (Auth.)

  14. Carnosine Attenuates the Development of both Type 2 Diabetes and Diabetic Nephropathy in BTBR ob/ob Mice

    NARCIS (Netherlands)

    Albrecht, Thomas; Schilperoort, Maaike; Zhang, Shiqi; Braun, Jana D.; Qiu, Jiedong; Rodriguez, Angelica; Pastene, Diego O.; Kraemer, Bernhard K.; Koeppel, Hannes; Baelde, Hans; de Heer, Emile; Altomare, Alessandra Anna; Regazzoni, Luca; Denisi, Alessandra; Aldini, Giancarlo; van den Born, Jacob; Yard, Benito A.; Hauske, Sibylle J.

    2017-01-01

    We previously demonstrated that polymorphisms in the carnosinase-1 gene (CNDP1) determine the risk of nephropathy in type 2 diabetic patients. Carnosine, the substrate of the enzyme encoded by this gene, is considered renoprotective and could possibly be used to treat diabetic nephropathy (DN). In

  15. Self-diffusion in volume and at the grain-boundaries of gamma-iron of high purity (99.99%); Autodiffusion en volume et aux joints de grains du fer gamma de haute purete (99,99 %); Ob'emnaya samodiffuziya i samodiffuziya na poverkhnosti granul zheleza u vysokoj chistoty (99,99%); Autodifusion en volumen y en los limites intergranulares del hierro gamma de elevada pureza (99,99 por ciento)

    Energy Technology Data Exchange (ETDEWEB)

    Lacombe, P; Guiraldenq, P; Leymonie, C [Centre de Recherches Metallurgiques, Ecole Nationale Superieure des Mines, Paris (France)

    1962-01-15

    1260 Degree-Sign y 918 Degree-Sign C, y de las constantes de autodifusion en las uniones intergranulares entre 1020 Degree-Sign y 918 Degree-Sign C. (author) [Russian] Vvidu trudnostej, s kotorymi vstretilis' pri tochnom izmerenii koehffitsientov samodiffuzii kak vnutri, tak i mezhdu samimi granulami v nekotorykh intervalakh temperatury, kogda sosushchestvuyut oba yavleniya, my byli vynuzhdeny pribegnut' k obychnomu metodu deleniya na chasti. V samom dele my uzhe ustanovili, chto dlya vyazkogo polutverdogo tela posle diffuzii kontsentratsiya radioaktivnykh atomov c (x{sub n}) na rasstoyanii x{sub n} ot pervonachal'nogo radioaktivnogo osadka yavlyaetsya prostoj funktsiej obshchej aktivnosti, kotoraya ostaetsya v obraztse posle abrazii na glubinu x{sub n}. EHtot vyvod yavlyaetsya rezul'tatom obobshcheniya formuly Gruzina, kotoraya do nastoyashchego vremeni primenyalas' tol'ko v ob{sup e}mnoj diffuzii. Takim obrazom my pokazali, chto mozhno putem izmereniya obshchej aktivnosti, ostayushchejsya v zavisimosti ot glubiny proniknoveniya razlichat' dolyu aktivnosti, kotoraya proiskhodit iz-za ob{sup e}mnoj samodiffuzii ot aktivnosti, proiskhodyashchej iz-za mezhgranulovoj samodiffuzii. Odnako tsennost' metoda zaklyuchaetsya v tom, chtoby prosledit' dal'she na tom zhe samom obraztse perekhod ob{sup e}mnoj samodiffuzii v mezhgranulovuyu samodiffuziyu. My primenili ehtot novyj metod dlya izmereniya konstant ob{sup e}mnoj samodiffuzii v zheleze u pri temperature 1260 Degree-Sign i 980 Degree-Sign C, a takzhe samodiffuzii na poverkhnosti granul pri temperature 1020 Degree-Sign i 918 Degree-Sign C. (author)

  16. Gridded Monthly Time-Mean Observation (obs) Values 0.5 x 0.667 degree V001 (MA_SSMI_DMSP13_OBS) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — The differences between the observations and the forecast background used for the analysis (the innovations or O-F for short) and those between the observations and...

  17. Apo-10'-lycopenoic acid, a lycopene 1 metabolite, increases sirtuin 1 mRNA and protein levels and decreases hepatic fat accumulation in ob/ob mice

    Science.gov (United States)

    Lycopene has been shown to be beneficial in protecting against high-fat diet-induced fatty liver. The recent demonstration that lycopene can be converted by carotene 99,10’-oxygenase into a biologically active metabolite, ALA, led us to propose that the function of lycopene can be mediated by ALA. I...

  18. Development of UO{sub 2}-Stainless Steel Fuel Plates Containing 30-50 Vol. % Oxide; Fabrication de plaques de combustible en acier inoxydable-UO{sub 2} contenant 30 a 40% d'oxyde (en volume); Razrabotka toplivnykh ehlementov iz nerzhaveyushchej stali i UO{sub 2}, soderzhashchikh 30 - 50 OB.% okisi; Elaboracion de placas de combustible de acero inoxidable UO{sub 2} conteniendo 30 a 40% de oxido (en volumen)

    Energy Technology Data Exchange (ETDEWEB)

    Lloyd, H. [Atomic Energy Research Establishment, Harwell (United Kingdom)

    1963-11-15

    de nucleos de cermets constituidos por placas con las particulas uniformemente distribuidas en la matriz de acero inoxidable, asi como procedimientos para unir las placas de combustible por laminacion en caliente. Se ha estudiado la laminacion a temperaturas de hasta 1300{sup o}C, utilizando deformaciones totales del orden del 40 al 90%, para determinar las condiciones optimas de produccion de nucleos de elevada densidad y obtener una union satisfactocia entre los componentes de las placas, con fragmentacion y estiraje minimos de las particulas de UO{sub 2} . Tambien se describe la fabricacion de grandes placas de combustible utilizando materiales polinucleares que se unen por laminacion en caliente. Se facilitan datos sobre las propiedades mecanicas de cermets de UO{sub 2} y acero inoxidable de 30, 40 y 50% en volumen, elaborados como se ha indicado y ensayados tal como quedan despues de laminarlos, y despues de someterlos a recocido a diversas temperaturas que alcanzaron hasta 700{sup o}C, utilizando probetas tomadas transversal y longitudinalmente con respecto a la direccion de laminado. Se examina la influencia del tamaflo y uniformidad de la distribucion de las esferas de UO{sub 2} en la estabilidad de las propiedades mecanicas. Tambien se evalua la solidez de la union entre el nucleo y el revestimiento de cermets del mismo tipo, en identico intervalo de temperaturas. Asimismo, se incluyen los resultados de los ensayos de ciclado termico efectuados entre 50 y 800{sup o}C con objeto de estudiar los efectos en la estructura del cermet y en la estabilidad de la union, despues de 100, 500 y 1000 ciclos. (author) [Russian] Daetsya opisanie protsessov izgotovleniya toplivnykh ehlementov plastinchatogo tipa iz UO{sub 2} i nerzhaveyushchej stali, soderzhashchikh do 50 ob% UO{sub 2}. Opisyvaetsya izgotovlenie ochen' plotnykh spekshikhsya sharoobraznykh chastits iz UO{sub 2} v intervale razmerov ot 100 do 500, a takzhe pressovanie i spekanie kermetnykh plastinchatykh

  19. Generation maintenance scheduling based on multiple ob jectives and their relationship analysis

    Institute of Scientific and Technical Information of China (English)

    Jun-peng ZHAN; Chuang-xin GUO; Qing-hua WU; Lu-liang ZHANG; Hong-jun FU

    2014-01-01

    In a market environment of power systems, each producer pursues its maximal profit while the independent system operator is in charge of the system reliability and the minimization of the total generation cost when generating the generation maintenance scheduling (GMS). Thus, the GMS is inherently a multi-objective optimization problem as its objectives usually conflict with each other. This paper proposes a multi-objective GMS model in a market environment which includes three types of objectives, i.e., each producer’s profit, the system reliability, and the total generation cost. The GMS model has been solved by the group search optimizer with multiple producers (GSOMP) on two test systems. The simulation results show that the model is well solved by the GSOMP with a set of evenly distributed Pareto-optimal solutions obtained. The simulation results also illustrate that one producer’s profit conflicts with another one’s, that the total generation cost does not conflict with the profit of the producer possessing the cheapest units while the total generation cost conflicts with the other producers’ profits, and that the reliability objective conflicts with the other objectives.

  20. Impact of educational messages on patient acceptance of male medical students in OB-GYN encounters.

    Science.gov (United States)

    Buck, Katherine; Littleton, Heather

    2016-09-01

    Although training in obstetrics and gynecology is a key part of medical education, male students receive less extensive experience, due in part to patient refusals. However, there is limited work seeking to reduce patient refusal rates of male students. The current study examined the efficacy of two messages at increasing male medical student acceptance into a well-woman visit. A total of 656 college women participated in a simulation study where they viewed a video of a nurse asking for permission to have a male medical student participate in their well-woman visit. The 30.5% of women who refused student participation (n = 181) were randomly assigned to view a video of the nurse either describing students' medical knowledge and technical skills training (e.g. training in performing pelvic exams) or empathic skills training (e.g. training in communication about sensitive issues). They were again asked if they would be willing to have the student participate. Both messages similarly increased student acceptance with 44.8% of those receiving the empathic skills training message and 48.9% of those who received the medical/technical skills training message accepting student participation, χ(2) (1, N = 181) = 0.3, p = 0.58. Educational messages about medical student training delivered in an engaging fashion by a credible source are a potentially effective tool to increase male student acceptance into sensitive patient encounters. Future work should test these messages in real-world settings as part of a focus on patient education to increase comfort with student participation.

  1. Opredelenije obščego zemnogo ellipsoida pri uslovii V.V.Brovara

    Czech Academy of Sciences Publication Activity Database

    Burša, Milan; Vatrt, V.; Kouba, J.; Šíma, Zdislav; Jurkina, M. I.

    č. 11 (2002), s. 6-9 ISSN 0016-7126 Institutional research plan: CEZ:AV0Z1003909 Keywords : Earth's ellipsoid * determination * semimajor axis Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

  2. Testing S3 API for OBS, and Federated AAI for HNSciCloud

    CERN Document Server

    Pintjuk, Daniil

    2016-01-01

    During my time at CERN join the HNSciCloud PCP project. A Pre-commercial Procurmet tender to develop a cloud platform to support high performance computing and big data capabilities for scientific research.

  3. Quantitative spectroscopic J-band study of red supergiants in Perseus OB-1

    International Nuclear Information System (INIS)

    Gazak, J. Zachary; Kudritzki, Rolf; Davies, Ben; Bergemann, Maria; Plez, Bertrand

    2014-01-01

    We demonstrate how the metallicities of red supergiant (RSG) stars can be measured from quantitative spectroscopy down to resolutions of ≈3000 in the J-band. We have obtained high resolution spectra on a sample of the RSG population of h and χ Persei, a double cluster in the solar neighborhood. We show that careful application of the MARCS model atmospheres returns measurements of Z consistent with solar metallicity. Using two grids of synthetic spectra–one in pure LTE and one with non-LTE (NLTE) calculations for the most important diagnostic lines–we measure Z = +0.04 ± 0.10 (LTE) and Z = –0.04 ± 0.08 (NLTE) for the sample of eleven RSGs in the cluster. We degrade the spectral resolution of our observations and find that those values remain consistent down to resolutions of less than λ/δλ of 3000. Using measurements of effective temperatures we compare our results with stellar evolution theory and find good agreement. We construct a synthetic cluster spectrum and find that analyzing this composite spectrum with single-star RSG models returns an accurate metallicity. We conclude that the RSGs make ideal targets in the near infrared for measuring the metallicities of star forming galaxies out to 7-10 Mpc and up to 10 times farther by observing the integrated light of unresolved super star clusters.

  4. Owner-Based Role-Based Access Control OB-RBAC

    NARCIS (Netherlands)

    Saffarian, M.; Sadighi, Babak

    Administration of an access control model deals with the question of who is authorized to update policies defined on the basis of that model. One of the models whose administration has absorbed relatively large research is the Role-Based Access Control (RBAC) model. All the existing role-based

  5. Ob istoricheskom kontekste innovacionnogo razvitija Rossii [On the historical context of innovative development in Russia

    Directory of Open Access Journals (Sweden)

    Krivosheev Vladimir

    2012-01-01

    Full Text Available The present analysis is based on the institutional model of research on social processes. Thus, the idea of possible modernisation of Russian society rests on the consideration of the current situation in the field of economics, management, and science. On the basis of a secondary analysis of statistical data and the works of Russian and international sociologists, this article describes the fundamental conceptual framework of the modernisation of Russian society. In particular, it focuses on the criticism of the modernisation project initiated by the forces that present themselves as conservative. The author also mentions significant problems arising during the modernisation of Russian society; these problems are rooted in both objective conditions of the on-going process and subjective factors. The article addresses the emergence and development of the modernisation idea in Russia. The relevance of this work lies in theidentification of the features of the transition of Russian society into a new phase, which reflects the trends of global innovative processes.

  6. Ob the Froissart-Martin bound in spaces with compact dimensions

    CERN Document Server

    Petrov, V A

    2002-01-01

    It is shown by the example of the 5-dimensional space-time, that by availability of the additional compact (space-time-like) measurements to the general Minkowski space all the conditions for proving the Froissart-Martin bound retain their force. Thus, by the circumference R -> 0 the theory smoothly transfers to the theory of the neutral scalar field in the 4-dimensional Minkowski space-time. It was assumed in this work, that the masses are bound from below by the non-zero value. The bounds for elastic scattering by absence of the mass gap are trivial, however in this case it is obviously possible to obtain also nontrivial bounds for complete inelastic cross sections. It takes place in the Regge-eikonal approach though there exist no strong proof for it

  7. Poetry They are people too (an Ob-Gyn intern's perspective)

    African Journals Online (AJOL)

    Correspondence: chikondichapuma@gmail.com. If I could get a kwacha every time. I met aNatchathu, aNabanda, aNasibeko or oNana and compassion flooded my heart. If I could get just a kwacha every time aNatchatu refused doctor's orders of, “no coitus” after her previous evacuation, afraid her septic miscarriage would ...

  8. Let your name be known. OB-GYN practice's marketing strategies keep it prominent in community.

    Science.gov (United States)

    Schneck, Lisa H

    2003-08-01

    Take a large dose of innovation, add a dollop of shrewd business sense and a heaping measure of community awareness, mix well, and you get the marketing success enjoyed by San Dimas Medical Group Inc. of Bakersfield, Calif. The practice has established wide name recognition, become a community benefactor and positioned itself as the practice that local women want to visit for a wide range of health concerns.

  9. Physical properties of seven binary and higher-order multiple OB systems

    Czech Academy of Sciences Publication Activity Database

    Mayer, P.; Harmanec, P.; Chini, R.; Nasseri, A.; Nemravová, J.; Drechsel, H.; Catalan-Hurtado, R.; Barlow, B.N.; Kotková, Lenka

    2017-01-01

    Roč. 600, April (2017), A33/1-A33/15 E-ISSN 1432-0746 R&D Projects: GA MŠk LG14013 Grant - others:GA ČR(CZ) GA15-02112S Institutional support: RVO:67985815 Keywords : spectroscopic * massive stars * fundamental parameters Subject RIV: BN - Astronomy , Celestial Mechanics, Astrophysics OBOR OECD: Astronomy (including astrophysics,space science) Impact factor: 5.014, year: 2016

  10. NGC 6334 and NGC 6357 Insights from spectroscopy of their OB star populations

    Czech Academy of Sciences Publication Activity Database

    Russeil, D.; Adami, C.; Bouret, J.-C.; Hervé, Anthony; Parker, Q.A.; Zavagno, A.; Motte, F.

    2017-01-01

    Roč. 607, November (2017), A86/1-A86/32 E-ISSN 1432-0746 Institutional support: RVO:67985815 Keywords : stars distances * HII regions * ISM Subject RIV: BN - Astronomy , Celestial Mechanics, Astrophysics OBOR OECD: Astronomy (including astrophysics,space science) Impact factor: 5.014, year: 2016

  11. Determination of OB/OD/SF Emission Factors Using Unmanned Aerial Systems

    Science.gov (United States)

    A presentation to the Demilitarization Symposium. This proposal will present the methods of tethered aerostat and unmanned aerial system for collection of plume samples and determination of emission factors form open burning, open detonation, and static firing for weapon demilita...

  12. DEBRIS DISKS IN THE SCORPIUS–CENTAURUS OB ASSOCIATION RESOLVED BY ALMA

    Energy Technology Data Exchange (ETDEWEB)

    Lieman-Sifry, Jesse; Hughes, A. Meredith; Flaherty, Kevin M. [Department of Astronomy, Van Vleck Observatory, Wesleyan University, 96 Foss Hill Drive, Middletown, CT 06459 (United States); Carpenter, John M. [Department of Astronomy, California Institute of Technology, MC 249-17, Pasadena, CA 91125 (United States); Gorti, Uma [SETI Institute, Mountain View, CA (United States); Hales, Antonio [Atacama Large Millimeter/Submillimeter Array, Joint ALMA Observatory, Alonso de Córdova 3107, Vitacura 763-0355, Santiago (Chile)

    2016-09-01

    We present a CO(2-1) and 1240 μ m continuum survey of 23 debris disks with spectral types B9-G1, observed at an angular resolution of 0.″5–1″ with the Atacama Large Millimeter/Submillimeter Array (ALMA). The sample was selected for large infrared excess and age ∼10 Myr, to characterize the prevalence of molecular gas emission in young debris disks. We identify three CO-rich debris disks, plus two additional tentative (3 σ) CO detections. Twenty disks were detected in the continuum at the >3 σ level. For the 12 disks in the sample that are spatially resolved by our observations, we perform an independent analysis of the interferometric continuum visibilities to constrain the basic dust disk geometry, as well as a simultaneous analysis of the visibilities and broadband spectral energy distribution to constrain the characteristic grain size and disk mass. The gas-rich debris disks exhibit preferentially larger outer radii in their dust disks, and a higher prevalence of characteristic grain sizes smaller than the blowout size. The gas-rich disks do not exhibit preferentially larger dust masses, contrary to expectations for a scenario in which a higher cometary destruction rate would be expected to result in a larger mass of both CO and dust. The three debris disks in our sample with strong CO detections are all around A stars: the conditions in disks around intermediate-mass stars appear to be the most conducive to the survival or formation of CO.

  13. VizieR Online Data Catalog: Radio obs. of NGC 6251 jet (Tseng+, 2016)

    Science.gov (United States)

    Tseng, C.-Y.; Asada, K.; Nakamura, M.; Pu, H.-Y.; Algaba, J.-C.; Lo, W.-P.

    2017-05-01

    We conducted European VLBI Network (EVN) observations of NGC 6251 on 2013 March 10 at 1.6GHz with the stations at Badary, Svetloe, Zelenchukskaya (Russia), Effelsberg (Germany), Jodrell Bank (UK), Medicina, Noto (Italy), Onsala (Sweden), Shanghai, Urumqi (China), Torun (Poland), and Westerbork (Netherlands). Archival Very Long Baseline Array (VLBA) data at 5GHz are used and calibrated in the same manner as the EVN data. Also, 12 epochs of the VLBA data at 15GHz are obtained from the MOJAVE database (Lister+ 2009, J/AJ/137/3718). Observations were conducted during 1998-2013. We also use a published VLA image of NGC 6251 at 1.4GHz to compare with the VLBI measurements in Section 4.1. The image, as well as the calibration processes, is shown in Sambruna+ (2004A&A...414..885S). Observations were conducted on 1995 August 15 using the full VLA in its A-configuration. The beam is restored to be circular with an FWHM of 2". (1 data file).

  14. OB fellowship outcomes 1992-2010: where do they go, who stops delivering, and why?

    Science.gov (United States)

    Rodney, W MacMillan; Martinez, Conchita; Collins, Millard; Laurence, Greg; Pean, Carl; Stallings, Joe

    2010-01-01

    This study describes characteristics and the evolution of the careers of graduates from a 1-year post-residency fellowship program whose primary objectives included clinical skills in Cesarean section. Besides obstetrical practice, rural service and attainment of faculty appointment were used as surrogate measures of fulfilling an underserved need for family medicine obstetrics. For 18 years, the authors maintained contact with all 80 physicians completing 1-year fellowships in family medicine obstetrics in Memphis and Nashville. The founding chair of these programs surveyed each physician and maintained a network of contacts to study outcomes such as graduation, service location, hospital privileges, retention, and career changes. The study tracked 100% of the sample and documented high rates of fellowship completion (74/80 [93%]), Cesarean privileges (71/74 [96%]), and service in a rural community for at least 2 years (47/74 [64%]). The fellowship was also associated with participation as faculty (36/74 [46%]). This paper produces the first and longest-term data describing attrition over time and examines the reasons why fellowship-trained family physicians stop doing maternity care. It is the only series with a 100% response rate and provides longitudinal data on the outcomes of these fellowship programs. Attrition was highest at rural sites. Workforce planners and fellowship designers might benefit from these considerations.

  15. Radiolysis ob benzene, toluene and phenol aqueous solutions utilizing high energy electron beam

    International Nuclear Information System (INIS)

    Gonzalez Vanderhaghen, D.E.

    1998-01-01

    In a search for solutions to environmental pollution problems, radiolysis has proved to be an innovative technique for the removal of organic chemical pollutants in aqueous solution. Radiolysis has shown many advantages over many other techniques, as highly reactive species formed in water by ionizing radiation oxidize organic pollutants breaking down organic molecules to final simple products by oxidation to carbon dioxide and water in a complete oxidation. Our work consisted in doing some experiments in radiolysis with simulated polluted water to help us understand this technique and also develop, in a near future, a project for large scale water treatment. Our project includes the application of a Pelletron type Mexican made Electron Accelerator, which will affirm its capability and usefulness in performing investigation in this field of study. Experiments consisted in treating benzene, toluene and phenol aqueous solutions with an Electron Beam (0.48-0.55 MeV; 24 μA). Two concentrations were used for each compound: 5 and 20 ppm (mg/l) for benzene and toluene; 10 and 50 ppm for phenol. Solutions were prepared with pure, mineral free water and two different p H (5.9), in order to study the effect of concentration and p H on removal efficiency, but avoiding the interference of radical scavengers. Results obtained coincide with the ones reported by Cooper, Nickelsen and Kurucz; highly efficient removal was achieved for benzene (>99.8%), toluene (>98.0%) and phenol (>88%). There was no visible important effect of p H on radiolysis efficiency for benzene nor toluene, phenol however, showed lower removal efficiency in acidic conditions. Concentration of aqueous solutions, nevertheless, did show an important effect at low doses for phenol. Results obtained reveal the importance of this technique in water pollution control and water remedial as expressed by Cooper, Nickelsen and Kurucz, who have studied radiolysis of organic compounds and apply this technique in water site remedial with a mobile Electron Beam facility. (Author)

  16. Recherche sur l'environnement alimentaire urbain obésogène, ses ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'étude, menée par une équipe pluridisciplinaire, est conçue selon une approche à différentes méthodes, y compris des enquêtes, des entrevues et l'analyse de politiques. L'University of the Western Cape (UWC) dirigera le projet en Afrique du Sud, et la Kwame Nkrumah University of Science and Technology (KNUST) ...

  17. Joint path and resource selection for OBS grids with adaptive offset based QOS mechanism

    OpenAIRE

    Köseoğlu, Mehmet

    2007-01-01

    Ankara : The Department of Electrical and Electronics Engineering and the Institute of Engineering and Sciences of Bilkent University, 2007. Thesis (Master's) -- Bilkent University, 2007. Includes bibliographical references leaves 71-76 It is predicted that grid computing will be available for consumers performing their daily computational needs with the deployment of high bandwidth optical networks. Optical burst switching is a suitable switching technology for this kind of...

  18. European Pond Turtles from Obříství (Bohemia, Czech Republic)

    Czech Academy of Sciences Publication Activity Database

    Kyselý, René; Čuláková, Katarína; Pecinovská, Monika; Široký, P.

    2016-01-01

    Roč. 26, č. 4 (2016), s. 732-739 ISSN 1047-482X Institutional support: RVO:67985912 Keywords : archaeozoology * Bohemia * Elbe (Labe) * Emys orbicularis * Hallstatt * Late Bronze Age * radiocarbon dating * reptiles Subject RIV: AC - Archeology, Anthropology, Ethnology Impact factor: 1.038, year: 2016

  19. Progetto NERIES: analisi preliminare dei dati della prima campagna OBS nello Ionio meridionale

    OpenAIRE

    D'Anna, G.; D'Alessandro, A.; Mangano, G.; Amato, A.; Piana Agostinetti, N.; Selvaggi, G.

    2008-01-01

    La definizione di un modello crostale per l’area dello Ionio è di fondamentale importanza per la comprensione dell’evoluzione geodinamica del Mediterraneo. Anche se quasi tutti gli autori concordano nel ritenere la crosta del Mar Ionio assimilabile a una crosta oceanica matura (De Voogd et al., 1992, Catalano et al., 2001; Finetti e Del Ben, 2005; Argnani, 2005), esistono tuttavia ipotesi alternative (Farrugia and Panza, 1981; Ismail-Zadeh et al., 1998..) e rimangono da chiarir...

  20. Účtování oběžného majetku

    OpenAIRE

    TRILLSAMOVÁ, Andrea

    2007-01-01

    The target of the bachelor´s work is the analysis of accounting and appreciation of current assets in specific accounting units. Next target is the comparison of current assets records in the trader shop and in the limited company. We distinguish the inventories, short-term receivables and short-term financial assets in current assets. The theoretical part of the work is given to the current assets dividing, accounting and appriciation. The practical part is given to the pragmatic solution of...

  1. Řízení oběžného majetku

    OpenAIRE

    CHMELAŘOVÁ, Adéla

    2016-01-01

    The main goal of the bachelor thesis named "Short - term asset management" is complex view and understanding of short term asset management and it is divided into 2 parts: first one is focused on the theory about short term asset and its structure and the management, second part - the practice - analyses short-term asset management in the PLEAS Company.

  2. Soils of slopes in the taiga zone of the Middle Ob reaches

    Science.gov (United States)

    Karavaeva, N. A.; Sokolova, T. A.

    2015-06-01

    The morphology, chemical properties, composition of phyllosilicates, as well as their transformation in loamy soils developing on slopes of ridges of the Vakh Upland in Western Siberia, are discussed. Data on two soil profiles-gleyic svetlozem of the middle slope and podzolized gleyzem of the footslope—are presented. Both soils have an acid reaction. The textural differentiation is weakly pronounced in the gleyic svetlozem and more pronounced in the podzolized gleyzem. The soils differ in their cryological conditions. The thawing depth in the svetlozem is about 60-70 cm, and the lower part of the profile to a depth of 3.2 m largely remains in the frozen state. Its complete thawing is only possible during the warm climatic cycles. This is a seasonally frozen soil with the long-lasting frozen state. It is characterized by the thick cryometamorphic (CRM) horizon. The gleyzem is a "normal" seasonally frozen soil with complete thawing of seasonal frost in summer. The CRM horizon is absent in its profile. The alteration of clay minerals in the soil profiles includes their partial dissolution, the formation of soil chlorites, and the transformation of illite into more labile structures. In the upper horizons of both soils, this transformation proceeds through the stage of mixed-layered illite-smectites. In the gleyzem, it reaches a more advanced stage of the formation of beidellite. The cryometamorphic horizons are specified by some amorphization of phyllosilicates and, probably, by the partial dissolution of their crystal lattices under the impact of frequent zero-temperature transitions and cryogenesis in the frozen state.

  3. Uprchlík, člověk a občan

    Czech Academy of Sciences Publication Activity Database

    Bierhanzl, Jan

    -, č. 1 (2016), s. 1-3 ISSN 1210-4361 Institutional support: RVO:67985955 Keywords : refugee * bare life * human rights * citizenship Subject RIV: AA - Philosophy ; Religion http://protestant.evangnet.cz/uprchlik-clovek-obcan

  4. 92-----------------------------~------------RE-SO-NANCEI--O-ct-ob-er-1-99-7

    Indian Academy of Sciences (India)

    Nuclear Science Centre (NSC) is the country's first inter-university research .... Radio-biology and Radiation Chemistry: Cell survival on irradiation, primary ... The NSC user family has grown to 47 universities, 26 colleges, 9 other teaching insti-.

  5. Experimental Demonstration of a Self-organized Architecture for Emerging Grid Computing Applications on OBS Testbed

    Science.gov (United States)

    Liu, Lei; Hong, Xiaobin; Wu, Jian; Lin, Jintong

    As Grid computing continues to gain popularity in the industry and research community, it also attracts more attention from the customer level. The large number of users and high frequency of job requests in the consumer market make it challenging. Clearly, all the current Client/Server(C/S)-based architecture will become unfeasible for supporting large-scale Grid applications due to its poor scalability and poor fault-tolerance. In this paper, based on our previous works [1, 2], a novel self-organized architecture to realize a highly scalable and flexible platform for Grids is proposed. Experimental results show that this architecture is suitable and efficient for consumer-oriented Grids.

  6. Using technology for global recruitment: why HR/OB scholars need US knowledge?

    NARCIS (Netherlands)

    Furtmueller-Ettinger, Elfriede

    2012-01-01

    This dissertation contributes to the Electronic Human Resource Management (e-HRM) literature and specifically aims to enhance our understanding on how to design and innovate e-Recruiting technologies. Despite many organizations that proudly advertise their success with e-Recruiting services, it

  7. Possible mechanism for mass transfer in X-ray binary systems with OB supergiant companions

    International Nuclear Information System (INIS)

    Alme, M.L.; Wilson, J.R.

    1976-01-01

    We have studied the ''beginning Roche lobe overflow'' phase of mass transfer. We find that before the primary fills its Roche lobe, radiation-driven density waves generated in the atmosphere produce a sufficient mass outflow rate to power a compact X-ray source. In particular, for a model of Cygnus X-1, if the radius of the photosphere is between 82 and 86 percent of the radius of the Roche equipotential, large-amplitude density waves with irregular periods of a few days are observed. These density waves, which are generated by radiation pressure effects, pass through the inner Lagrangian point with velocities approx.100 km s -1 , and can easily provide sufficient material to power the compact X-ray source

  8. Porous Na2O-B2O3-Nd2O3 material

    Energy Technology Data Exchange (ETDEWEB)

    De Villiers, D R; Res, M A; Richter, P W

    1986-12-01

    Substitution of SiO2 by Nd2O3 in the sodium borosilicate system produced glasses containing up to 50 mass% Nd2O3. Sodium borate was leached out of some of the materials to produce either a porous Nd2O3-rich glass or a porous glass-ceramic containing NdBO3, depending on the starting material. Surface areas of up to 190 mS g- were measured. Powder X-ray diffraction (XRD) revealed the NdBO3 to be the high-temperature form with low symmetry.

  9. Using technology for global recruitment: why HR/OB scholars need US knowledge?

    OpenAIRE

    Furtmueller-Ettinger, Elfriede

    2012-01-01

    This dissertation contributes to the Electronic Human Resource Management (e-HRM) literature and specifically aims to enhance our understanding on how to design and innovate e-Recruiting technologies. Despite many organizations that proudly advertise their success with e-Recruiting services, it cannot be denied that many of these organizations – after years of experimenting with it – have already abandoned e-Recruiting, retreating to timeworn routine recruiting techniques such as newspaper ad...

  10. Občanský politik Karel Kramář

    Czech Academy of Sciences Publication Activity Database

    Pavlíček, Tomáš W.

    2016-01-01

    Roč. 29, 21. 12. (2016), s. 18 ISSN 0862-5921 Grant - others:AV ČR(CZ) StrategieAV21/12 Program:StrategieAV Institutional support: RVO:67985921 Keywords : World War I * Kramář, Karel Subject RIV: AB - History

  11. Dopady šikanování na osobnost oběti

    OpenAIRE

    Šnoblová, Vladěna

    2014-01-01

    This bachelor's thesis pursues the subject of bullying and its possible impacts on people who became victims of this behaviour. The first part of thesis contains definitions of the terms bullying, cyberbullying, mobbing and bossing. It also follows the roles of individual participants of bullying and other kinds of aggression connected to it. Following part of thesis deals with possible views on bullying and social-psychological theories which can relate to bullying as a social phenomenon. Es...

  12. OBS ervations on the vegetative propagation of the marine alga, Gelidiella acerosa (Forssk) Feldmann and Hamel

    Digital Repository Service at National Institute of Oceanography (India)

    Rao, P.P.S.; Tarwadi, S.J.; Chauhan, V.D.

    of this the present work on the vegetative propagation of the alga was planned. The cultures of the vegetative cut pieces of a frond of the species were grown in different culture media. The culture media were of sea water enriched with inorganic nutrient...

  13. Vakuumski baloni: at bicentenary of Vega's death: ob dvestoletnici Vegove smrti: Vacuum balloons:

    OpenAIRE

    Južnič, Stanislav

    2002-01-01

    We described the vacuum balloons that were developed in the 17th and 18th centuries parallel with the hot air and hydrogen balloons. We find the technological problems that postponed their effective use in the first place. At the bicentenary of Vega's death we discussed his opinion about the vacuum ballonns. We discussed some difficulties of their modern development. Opisujemo vakuumske balone, ki so jih razvijali vzporedno s toplozračnimi in vodikovimi v 17. in 18. stoletju. Izpostavljamo...

  14. VizieR Online Data Catalog: WSRT survey of Cygnus OB2 (Setia Gunawan+, 2003)

    Science.gov (United States)

    Setia Gunawan, D. Y. A.; de Bruyn, A. G.; van der Hucht, K. A.; Williams, P. M.

    2003-11-01

    The Cygnus region is too large to be imaged with a single pointing of the 25m dishes of the WSRT. The half-power beamwidths (HPBW) of the WSRT at 350 and 1400MHz are about 2.4{deg} and 0.6{deg}, respectively. Therefore, we used a mosaicking technique at both frequencies. The 350MHz observations were taken in 1994 as part of a larger survey of the Galactic plane in the Cygnus area (Vashist & de Bruyn, unpublished); only a small part of it is used in this study. (2 data files).

  15. Observations of suspended sediment from ADCP and OBS measurements in a mud-dominated environment

    NARCIS (Netherlands)

    Hoitink, A.J.F.; Hoekstra, P.

    2005-01-01

    The ability of a 1.2-MHz Acoustic Doppler Current Profiler (ADCP) to measure suspended sediment concentration (SSC) and particle size variation in a mud-dominated environment has been investigated. Experiments were conducted in the Bay of Banten, Indonesia, where clays and silts in the range of 3-55

  16. EPOXI EXOPLANET TRANSIT OBS - HRIV CALIBRATED IMAGES V1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set set contains calibrated images of eight known transiting extrasolar planetary systems (hot Jupiters) acquired by the Deep Impact High Resolution...

  17. A Rigidly Rotating Magnetosphere Model for the Circumstellar Environments of Magnetic OB Stars

    Science.gov (United States)

    Townsend, R.; Owocki, S.; Groote, D.

    2005-11-01

    We report on a new model for the circumstellar environments of rotating, magnetic hot stars. This model predicts the channeling of wind plasma into a corotating magnetosphere, where -- supported against gravity by centrifugal forces -- it can steadily accumulate over time. We apply the model to the B2p star σ Ori E, demonstrating that it can simultaneously reproduce the spectroscopic, photometric and magnetic variations exhibited by the star.

  18. Coupling hydrodynamics with comoving frame radiative transfer. I. A unified approach for OB and WR stars

    Science.gov (United States)

    Sander, A. A. C.; Hamann, W.-R.; Todt, H.; Hainich, R.; Shenar, T.

    2017-07-01

    Context. For more than two decades, stellar atmosphere codes have been used to derive the stellar and wind parameters of massive stars. Although they have become a powerful tool and sufficiently reproduce the observed spectral appearance, they can hardly be used for more than measuring parameters. One major obstacle is their inconsistency between the calculated radiation field and the wind stratification due to the usage of prescribed mass-loss rates and wind-velocity fields. Aims: We present the concepts for a new generation of hydrodynamically consistent non-local thermodynamical equilibrium (non-LTE) stellar atmosphere models that allow for detailed studies of radiation-driven stellar winds. As a first demonstration, this new kind of model is applied to a massive O star. Methods: Based on earlier works, the PoWR code has been extended with the option to consistently solve the hydrodynamic equation together with the statistical equations and the radiative transfer in order to obtain a hydrodynamically consistent atmosphere stratification. In these models, the whole velocity field is iteratively updated together with an adjustment of the mass-loss rate. Results: The concepts for obtaining hydrodynamically consistent models using a comoving-frame radiative transfer are outlined. To provide a useful benchmark, we present a demonstration model, which was motivated to describe the well-studied O4 supergiant ζPup. The obtained stellar and wind parameters are within the current range of literature values. Conclusions: For the first time, the PoWR code has been used to obtain a hydrodynamically consistent model for a massive O star. This has been achieved by a profound revision of earlier concepts used for Wolf-Rayet stars. The velocity field is shaped by various elements contributing to the radiative acceleration, especially in the outer wind. The results further indicate that for more dense winds deviations from a standard β-law occur.

  19. Can enriching emotional intelligence improve medical students’ proactivity and adaptability during OB/GYN clerkships?

    Science.gov (United States)

    Guseh, Stephanie H.; Chen, Xiaodong P.

    2015-01-01

    Objectives The purpose of this pilot study was to examine our hypothesis that enriching workplace emotional intelligence through resident coaches could improve third-year medical students’ adaptability and proactivity on the Obstetrics and Gynecology clerkship. Methods An observational pilot study was conducted in a teaching hospital. Fourteen 3rd year medical students from two cohorts of clerkships were randomly divided into two groups, and equally assigned to trained resident coaches and untrained resident coaches. Data was collected through onsite naturalistic observation of students’ adaptability and proactivity in clinical settings using a checklist with a 4-point Likert scale (1=poor to 4=excellent). Wilcoxon rank-sum test was used to compare the differences between these two groups. Results A total of 280 data points were collected through onsite observations conducted by investigators. All (n=14) students’ adaptability and proactivity performance significantly improved from an average of 3.04 to 3.45 (p=0.014) over 6-week clerkship. Overall, students with trained resident coaches adapted significantly faster and were more proactive in the obstetrics and gynecology clinical setting than the students with untrained coaches (3.31 vs. 3.24, p=0.019). Conclusions Findings from our pilot study supported our hypothesis that enriching workplace emotional intelligence knowledge through resident coaches was able to help medical students adapt into obstetrics and gynecology clinical settings faster and become more proactive in learning. Clerkship programs can incorporate the concept of a resident coach in their curriculum to help bridge medical students into clinical settings and to help them engage in self-directed learning throughout the rotation. PMID:26708233

  20. Can enriching emotional intelligence improve medical students' proactivity and adaptability during OB/GYN clerkships?

    Science.gov (United States)

    Guseh, Stephanie H; Chen, Xiaodong P; Johnson, Natasha R

    2015-12-26

    The purpose of this pilot study was to examine our hypothesis that enriching workplace emotional intelligence through resident coaches could improve third-year medical students' adaptability and proactivity on the Obstetrics and Gynecology clerkship. An observational pilot study was conducted in a teaching hospital. Fourteen 3rd year medical students from two cohorts of clerkships were randomly divided into two groups, and equally assigned to trained resident coaches and untrained resident coaches. Data was collected through onsite naturalistic observation of students' adaptability and proactivity in clinical settings using a checklist with a 4-point Likert scale (1=poor to 4=excellent). Wilcoxon rank-sum test was used to compare the differences between these two groups. A total of 280 data points were collected through onsite observations conducted by investigators. All (n=14) students' adaptability and proactivity performance significantly improved from an average of 3.04 to 3.45 (p=0.014) over 6-week clerkship. Overall, students with trained resident coaches adapted significantly faster and were more proactive in the obstetrics and gynecology clinical setting than the students with untrained coaches (3.31 vs. 3.24, p=0.019). Findings from our pilot study supported our hypothesis that enriching workplace emotional intelligence knowledge through resident coaches was able to help medical students adapt into obstetrics and gynecology clinical settings faster and become more proactive in learning. Clerkship programs can incorporate the concept of a resident coach in their curriculum to help bridge medical students into clinical settings and to help them engage in self-directed learning throughout the rotation.

  1. Study of the impact of environmental bacteria ob uranium speciation in order to engage bioremediation process

    International Nuclear Information System (INIS)

    Untereiner, G.

    2008-11-01

    Uranium is both a radiological and a chemical toxic. Its concentration in the environment is low except when human activities have caused pollution. Uranium is a heavy reactive element, and thus it is easily complexed with soil component like minerals or organic molecules. These different complexes can be more or less bioavailable for microorganisms and plants, and then get in the human food chain. The knowledge and the understanding of transfer mechanisms and also the fate of toxic elements in the biosphere are a key issue to estimate health and ecological hazards. The knowledge of the speciation is very important for bioremediation processes. Here, we focused on the microorganisms effects onto uranium speciation in environment. Bacteria can accumulate and/or transform uranium depending on the initial form of the element. Thus, its bioavailability could be changed. The species used in this work are Cupriavidus metallidurans CH34, which is an environmental bacteria with a high resistance to heavy metal, Deinococcus radiodurans R1, which is known for his radiological resistance, and Rhodopseudomonas palustris, which is a purple photo-trophic bacteria capable of degrading aromatic compounds. Two forms of uranium were used with these bacteria, a mineral one, uranyl carbonate, and an organic one, uranyl citrate. In a first step, the growth media were modified in order to stabilize uranium complexes thanks to a simulation program. Then, the capacity of the bacteria to accumulate or transform uranium was studied. We saw a difference between minimal inhibition concentrations of these two speciation which is due to a difference between phosphate bioavailability. No accumulation was observed with environmental pH but uranium precipitation was observed with acidic pH (pH 1). Uranium speciation seemed to be well controlled in the growth media and the precipitates were uranyl phosphate. (author)

  2. Gender a občanství v multikulturní Evropě

    Czech Academy of Sciences Publication Activity Database

    Hašková, Hana

    2007-01-01

    Roč. 8, č. 1 (2007), s. 56-60 ISSN 1213-0028 Grant - others:6 RP(XE) 028746-2 Institutional research plan: CEZ:AV0Z70280505 Keywords : gender * citizenship * multiculture Subject RIV: AO - Sociology, Demography http://www.genderonline.cz

  3. Can enriching emotional intelligence improve medical students? proactivity and adaptability during OB/GYN clerkships?

    OpenAIRE

    Guseh, Stephanie H.; Chen, Xiaodong P.; Johnson, Natasha R.

    2015-01-01

    Objectives: The purpose of this pilot study was to examine our hypothesis that enriching workplace emotional intelligence through resident coaches could improve third-year medical students’ adaptability and proactivity on the Obstetrics and Gynecology clerkship. Methods: An observational pilot study was conducted in a teaching hospital. Fourteen 3rd year medical students from two cohorts of clerkships were randomly divided into two groups, and equally assigned to trained resident coaches and ...

  4. Evalvacija nivojskega pouka pri pouku slovenščine v 8. in 9. razredih na osnovnih šolah v občinah Ormož, Središče ob Dravi in Sveti Tomaž

    OpenAIRE

    Lalić, Marko

    2012-01-01

    Mnenja o učni diferenciaciji in individualizaciji pouka ter z njima povezanim nivojskim poukom so že od samega začetka predmet nasprotujočih si mnenj tako pri strokovnjakih kot pri laikih. Nivojski pouk, ki je v veljavi vse od leta 1996, je poskrbel, da proces poučevanja poteka na drugačnem učiteljevem pristopu, na večji učenčevi aktivnosti, povezovanju učnih vsebin in prilagajanju učenčevih individualnih posebnosti. Leta 2006 je bil nivojski pouk kot sistemski ukrep opuščen. Šolam pa je bilo...

  5. "Obětuj tyto náušnice...". Lidská gesta a problém "oběti" osobních šperků

    Czech Academy of Sciences Publication Activity Database

    Profantová, Naďa

    2011-01-01

    Roč. 33, č. 9 (2011), s. 22-23 ISSN 0418-5129 R&D Projects: GA ČR GA404/09/1135 Institutional research plan: CEZ:AV0Z80020508 Keywords : early medieval * Bohemia * religious offering in grave Subject RIV: AC - Archeology, Anthropology, Ethnology

  6. Turkish Jewelry Technology Pre-Service Teachers' TPCK Integration through Ob-Video Materials: A Pedagogical Action Research

    Science.gov (United States)

    Akay, Cenk

    2017-01-01

    The utilization of educational technologies in class applications and their reflections on the education have not reached to desired levels today; in other words, there are problems in the integration of technology into teaching and using technology in conjunction with the knowledge of subject field and pedagogy. The aim of this research is to…

  7. An Investigation of the Vibration Characteristics of the Eurocopter AS35OB Main Rotor Gearbox Under Different Operating Conditions

    National Research Council Canada - National Science Library

    Wang, Wenyi

    2001-01-01

    Different flight conditions can introduce complex changes to the vibration of helicopter transmissions, which may cause a vibration-based in-flight transmission diagnostic system to produce false alarms...

  8. Microprobing of nuclear-dangerous materials in object << Shelter >>.; Mikrozondirovanie yadernoopasnykh delyashchikhsya materialov v ob`ekte << Ukrytie >>.

    Energy Technology Data Exchange (ETDEWEB)

    Ivanov, S I; Shostak, V B; Shcherbina, V G [Kievskij Gosudarstvennyj Univ., Kiev (Ukraine); [Myizhgaluzevij Naukovo-Tekhnyichnij Tsentr ` ` Ukrittya ` ` , Natsyional` na Akademyiya Nauk Ukrayini, Chornobil` (Ukraine)

    1994-12-31

    Peculiarities of neutron echo from the nuclear fuel induced by fission have been devised for solving problems of nuclear and radiation safety of object << Shelter >>. Practical scheme of this method for definition of the structure and situation of nuclear fuel is suggested.

  9. Aktivní občanství a spokojenost s demokracií v Evropě

    Czech Academy of Sciences Publication Activity Database

    Vlachová, Klára; Lebeda, Tomáš

    2006-01-01

    Roč. 42, č. 1 (2006), s. 11-34 ISSN 0038-0288 R&D Projects: GA ČR GA403/04/1219 Institutional research plan: CEZ:AV0Z70280505 Keywords : political participation * active citizenship * democracy satisfaction Subject RIV: AO - Sociology, Demography Impact factor: 0.128, year: 2006

  10. VizieR Online Data Catalog: High quality Spitzer/MIPS obs. of F4-K2 stars (Sierchio+, 2014)

    Science.gov (United States)

    Sierchio, J. M.; Rieke, G. H.; Su, K. Y. L.; Gaspar, A.

    2016-11-01

    We used specific criteria to draw samples of stars from the entire Spitzer Debris Disk Database (see section 2.1.1). V magnitudes were taken from Hipparcos and transformed to Johnson V. All stars were also required to have observations on the Two Micron All Sky Survey (2MASS) Ks system. Additional measurements were obtained at SAAO on the 0.75m telescope using the MarkII Infrared Photometer (transformed as described by Koen et al. 2007MNRAS.380.1433K), and at the Steward Observatory 61 in telescope using a NICMOS2-based camera with a 2MASS filter set and a neutral density filter to avoid saturation. These measurements will be described in a forthcoming paper (K. Y. L. Su et al., in preparation). The original programs in which our sample stars were measured are identified in Table 1. A large majority (93%) come from seven Spitzer programs: (1) the MIPS Guaranteed Time Observer (GTO) Sun-like star observations (Trilling+ 2008ApJ...674.1086T); (2) Formation and Evolution of Planetary Systems (FEPS; Meyer+ 2006, J/PASP/118/1690); (3) Completing the Census of Debris Disks (Koerner+ 2010ApJ...710L..26K); (4) potential Space Interferometry Mission/Terrestrial Planet Finder (SIM/TPF) targets (Beichman+ 2006ApJ...652.1674B); (5) an unbiased sample of F-stars (Trilling+ 2008ApJ...674.1086T); and (6) two coordinated programs selecting stars on the basis of indicators of youth (Low+ 2005ApJ...631.1170L; Plavchan+ 2009ApJ...698.1068P). See section 2.1.2. (1 data file).

  11. Marketingová strategie vybraného občanského sdružení.

    OpenAIRE

    Burešová, Kamila

    2011-01-01

    The diploma thesis "Marketing strategy of selected civic association" aims to the problem of marketing strategy and its application to non-profit organizations. Theoretical part defines non-profit organizations, where Civic association "Šestikráska" belongs, describes marketing strategy with all its parts and marketing mix. The practical part presents the history and activity of Civic association "Šestikráska", implements the marketing analysis and marketing mix. The aim of this thesis is to ...

  12. Determination of Mantle Discontinuity Depths beneath the South Pacific Superswell As Inferred Using Data From Broadband OBS Array

    Science.gov (United States)

    Suetsugu, D.; Shiobara, H.; Sugioka, H.; Kanazawa, T.; Fukao, Y.

    2005-12-01

    We determined depths of the mantle discontinuities (the 410-km and 660-km discontinuities) beneath the South Pacific Superswell using waveform data from broadband ocean bottom seismograph (BBOBS) array to image presumed mantle plumes and their temperature anomalies. Seismic structure beneath this region had not previously been well explored in spite of its significance for mantle dynamics. The region is characterized by a topographic high of more than 680 m (Adam and Bonneville, 2005), a concentration of hotspot chains (e.g., Society, Cook-Austral, Marquesas, and Pitcairn) whose volcanic rocks have isotopic characteristics suggesting deep mantle origin, and a broad low velocity anomaly in the lower mantle revealed by seismic tomography. These observations suggest the presence of a whole-mantle scale upwelling beneath the region, which is called a 'superplume' (McNutt, 1998). However, the seismic structure has been only poorly resolved so far and the maximum depth of anomalous material beneath the hotspots has not yet been determined, mainly due to the sparseness of seismic stations in the region. To improve the seismic coverage, we deployed an array of 10 BBOBS over the French Polynesia area from 2003 to 2005. The BBOBS has been developed by Earthquake Research Institute of University of Tokyo and are equipped with the broadband CMG-3T/EBB sensor. The observation was conducted as a Japan-France cooperative project (Suetsugu et al., 2005, submitted to EOS). We computed receiver functions from the BBOBS data to detect Ps waves from the mantle discontinuities. The Velocity Spectrum Stacking method (Gurrola et al., 1994) were employed to enhance the Ps waves for determination of the discontinuity depths, in which receiver functions were stacked in a depth-velocity space. The Ps-waves from the mantle discontinuities were successfully detected at the most of the BBOBS stations, from which the discontinuity depths were determined with the Iasp91 velocity model. The 410-km discontinuity depths were estimated to be 403-431 km over the Superswell region, which are not substantially different from the global average considering the estimation error of 10 km. The 660-km discontinuity depths were also determined to be 654-674 km, close to the global average, at most of the stations. Data from a station near the Society hot spot, however, provide an anomalously shallow depth of 623 km, indicating a presence of a local hot anomaly at the bottom of the mantle transition zone beneath near the Society hot spot. Taking into consideration a possible effect of velocity anomalies on the depth estimation, the shallow anomaly is significant. The present result suggests that the thermal anomalies are not obvious in the Superswell-scale, but present locally beneath the Society hot spot.

  13. Wpływ wysokości długu publicznego na koszty jego obsługi

    Directory of Open Access Journals (Sweden)

    Michał Brzozowski

    2013-06-01

    Full Text Available Purpose: The article aims at analyzing the functional form of the relation between the level of public debt and the government bond yields in both developed and developing countries. A surge in public indebtedness following the financial crisis in 2008-2010 undermined the credibility of sovereigns in the credit markets. As a result, the government bond yields have risen, thus amplifying the problem of rapidly expanding public debts. The purpose of the article is to estimate the threshold value of government debt above which its service costs rapidly increase.Methodology: The relation between the 10-year government bond real interest rate and the level of debt is investigated with the use of spline regression with cubic splines. The regression model is estimated using annual data for 66 countries that spans between the years 1980-2010. An additional analysis is conducted for the last decade and after splitting the sample into high-income and catching-up countries.Findings: In the sample that covers all countries and the whole 1980-2010 period no relation between the level of debt and interest rate has been detected. In the years 2001-2010 the threshold value of debt above which the real interest rate starts to grow rapidly is estimated to be around 150% of GDP in catching-up countries and about 110% of GDP in high-income countries.Research implications: An analysis of the impact of fiscal policy on the level of interest should take into account the likely non-linearity of the relationship.Originality: Spline regression has not yet been used in the analysis of the relation between debt and interest rate.

  14. Proces adaptace českých občanů na cizí kulturu

    OpenAIRE

    Bakiş, Zuzana

    2016-01-01

    This bachelor thesis deal with the process of adaptation of Czech people to foreign culture, concretely Turkish culture. The thesis focuses on how Czech people perceive Turkish culture and how are they able to adjust to it. The theoretical part explains terms from cross-cultural psychology such as culture, nation, acculturation, adaptation, cultural shock etc. In this part of the thesis are also introduced dimensions of national culture by Geert Hofstede and a comparison of Czech and Turkish ...

  15. VizieR Online Data Catalog: RVs and R-band obs. of the EB* V541 Cyg (Torres+, 2017)

    Science.gov (United States)

    Torres, G.; McGruder, C. D.; Siverd, R. J.; Rodriguez, J. E.; Pepper, J.; Stevens, D. J.; Stassun, K. G.; Lund, M. B.; James, D.

    2017-10-01

    V541 Cyg was observed spectroscopically at the Harvard-Smithsonian Center for Astrophysics (CfA) with the Digital Speedometer (DS) on the 1.5m Tillinghast reflector at the Fred L. Whipple Observatory on Mount Hopkins (AZ). We gathered 72 exposures between 2000 July and 2004 October (R~35000). Observations of V541 Cyg were obtained between 2007 May and 2014 November in the course of the Kilodegree Extremely Little Telescope transiting planet program (KELT). The passband of these observations resembles that of a very broad R-band filter. The magnitudes given in tables 2 and 3 are instrumental (not referring to a standard photometric system). (3 data files).

  16. VizieR Online Data Catalog: Cool-core clusters with Chandra obs. (Andrade-Santos+, 2017)

    Science.gov (United States)

    Andrade-Santos, F.; Jones, C.; Forman, W. R.; Lovisari, L.; Vikhlinin, A.; van Weeren, R. J.; Murray, S. S.; Arnaud, M.; Pratt, G. W.; Democles, J.; Kraft, R.; Mazzotta, P.; Bohringer, H.; Chon, G.; Giacintucci, S.; Clarke, T. E.; Borgani, S.; David, L.; Douspis, M.; Pointecouteau, E.; Dahle, H.; Brown, S.; Aghanim, N.; Rasia, E.

    2018-02-01

    The main goal of this work is to compare the fraction of cool-core (CC) clusters in X-ray-selected and SZ-selected samples. The first catalog of 189 SZ clusters detected by the Planck mission was released in early 2011 (Planck Collaboration 2011, VIII/88/esz). A Chandra XVP (X-ray Visionary Program--PI: Jones) and HRC Guaranteed Time Observations (PI: Murray) combined to form the Chandra-Planck Legacy Program for Massive Clusters of Galaxies. For each of the 164 ESZ Planck clusters at z<=0.35, we obtained Chandra exposures sufficient to collect at least 10000 source counts. The X-ray sample used here is an extension of the Voevodkin & Vikhlinin (2004ApJ...601..610V) sample. This sample contains 100 clusters and has an effective redshift depth of z<0.3. All have Chandra observations. Of the 100 X-ray-selected clusters, 49 are also in the ESZ sample, and 47 are in the HIFLUGCS (Reiprich & Boehringer 2002ApJ...567..716R) catalog. (2 data files).

  17. Právo oběti na kompenzaci za újmu způsobenou pachatelem

    OpenAIRE

    RUSÍNOVÁ, Dana

    2012-01-01

    The bachelor thesis has been focused on an examination of the crime victim's rights listed in the legal order of the Czech Republic. In connection with the victim's rights it deals with an impact of an amendment of the Criminal Act on the status of the crime victims, when it comes to a significant strengthening of crime victims' procedural right. The victim will have a much greater opportunity to express to the crime during the criminal proceedings itself, to describe his/her own mental condi...

  18. Versions of tubes combining for ionization `spaghetti`-calorimeter; Varianty ob``edineniya trubok ionizatsionnogo `spagetti`-kalorimetra

    Energy Technology Data Exchange (ETDEWEB)

    Misyura, S P; Smol` , A V

    1994-12-31

    The theoretical analysis of some electrical schemes of tubes combining intended for ionization `spaghetti`-calorimeter is presented. The expediency of the parallel tubes connection is shown for all schemes being considered. The restrictions for the parameters of scheme elements (blocking capacitors, matching transformer etc.) have been deduced. 10 refs., 23 figs.

  19. Determination of OB Emission Factors Using an Unmanned Aerial System (“drone”) at ?Radford Army Ammunition Plant

    Science.gov (United States)

    A description of the emission sampling via UAV at the Radford Army Ammunition Plant including number of samples, waste composition, UAV flight data. No emissions data presented; only qualitative description.

  20. VizieR Online Data Catalog: GMOS spectroscopic obs. of SNR candidates in M83 (Winkler+, 2017)

    Science.gov (United States)

    Winkler, P. F.; Blair, W. P.; Long, K. S.

    2017-11-01

    We used the GMOS on the 8.2m Gemini-South telescope to obtain all the spectra reported here. Most were obtained in a classically scheduled observing run on 2011 April 7-9 (UT); masks 1-7. We later obtained spectra for two additional masks (which we refer to as masks 8 and 9 for simplicity) in a queue-scheduled program (GS-2015A-Q-90) during the 2015A semester. (6 data files).

  1. Třetí sektor a občanská participace v České republice

    Czech Academy of Sciences Publication Activity Database

    Rakušanová, Petra

    2003-01-01

    Roč. 1, 3-4 (2003), s. 31-34 ISSN 1214-438X R&D Projects: GA AV ČR IBS7028003 Institutional research plan: CEZ:AV0Z7028912 Keywords : third sector * NGO * participation Subject RIV: AD - Politology ; Political Sciences

  2. Measuring the rotation periods of 4-10 Myr T-Tauri stars in the Orion OB1 association

    Science.gov (United States)

    Karim, Md Tanveer; Stassun, Keivan; Briceno, Cesar; Vivas, Kathy; Raetz, Stefanie; Calvet, Nuria; Mateu, Cecilia; Downes, Juan Jose; Hernandez, Jesus; Neuhäuser, Ralph; Mugrauer, Markus; Takahashi, Hidenori; Tachihara, Kengo; Chini, Rolf; YETI

    2016-01-01

    Most existing studies of young stellar populations have focused on the youngest (Investigaciones de Astronomía-Quest Equatorial Survey Team (CIDA-QUEST), the Young Exoplanet Transit Initiative (YETI) and from a Kitt Peak National Observatory (KPNO) campaign. We investigated stellar rotation periods according to the type of stars (Classical or Weak-lined T-Tauri stars) and their locations, to look for population-wide trends. We detected 563 periodic variables and 1411 non-periodic variables by investigating the light curves of these stars. We find that ~ 30% of Weak-line T-Tauri stars (WTTS) and ~ 20% of Classical T-Tauri stars (CTTS) are periodic. Though we did not find any noticeable difference in rotation period between CTTS and WTTS, our study does show a change in the overall rotation periods of stars 4-10 Myr old, consistent with predictions of angular momentum evolution models, an important constraint for theoretical models for an age range for which no similar data existed.

  3. Organizace občanské společnosti v kinematografii v ČR po roce 1989

    OpenAIRE

    Marečková, Lenka

    2011-01-01

    This thesis deals with civil society organizations in the field of cinema in the Czech Republic. Cinematography is part of art and industry, with further influences of technology, culture, social or political situation. As in other areas there creates also civil society in the field of cinematography. The aim of this work is to determine the reasons are civil society organization formed and how they function. Due to the broad approach of the target group the research proje...

  4. Spatial clustering of summer temperature maxima from the CNRM-CM5 climate model ensembles & E-OBS over Europe

    OpenAIRE

    Margot Bador; Philippe Naveau; Eric Gilleland; Mercè Castellà; Tatiana Arivelo

    2015-01-01

    Reducing the dimensionality of the complex spatio-temporal variables associated with climate modeling, especially ensembles of climate models, is a challenging and important objective. For studies of detection and attribution, it is especially important to maintain information related to the extreme values of the atmospheric processes. Typical methods for data reduction involve summarizing climate model output information through means and variances, which does not preserve any information ab...

  5. Potenciál rozvoje "temné turistiky" pro občany České republiky

    OpenAIRE

    Boháčová, Petra

    2014-01-01

    The topic of the bachelor thesis is dark tourism as one of the specific (new) forms of tourism. The work is divided into two parts. The theoretical part includes a definition of dark tourism, states some of its well known attractions and outlines the history and present state of this phenomenon. Some different categorizations of dark tourism are described in the work, especially the categorization by supply. It is based on a theoretical concept of the dark tourism spectrum, which explains why...

  6. OB in a Video Box: Using "Remember the Titans" as a Microcosm for the Organizational Behavior Course

    Science.gov (United States)

    Holbrook, Robert L., Jr.

    2009-01-01

    The use of movies and television in teaching is growing in popularity. Although a number of publications describe movies for use in the classroom, no single suggestion has been offered as an example that covers all the basic concepts of an organizational behavior course. Disney's "Remember the Titans" is that movie and, as such, is a valuable tool…

  7. On the energy spectrum of the Bethe-Salpeter equation; Ob ehnergeticheskom spektre uravneniya Bete-Solpitera

    Energy Technology Data Exchange (ETDEWEB)

    Dorkin, S M [Dal` nevostochnyj Gosudarstvennyj Univ., Vladivostok (Russian Federation); Kaptar` , L P; Semikh, S S [Joint Inst. for Nuclear Research, Dubna (Russian Federation). Lab. of Theoretical Physics

    1997-12-31

    The problem of calculating the energy spectrum of a two-fermion bound state within the Bethe-Salpeter formalism is discussed. An expansion of the kernel of the spinor-spinor Bethe-Salpeter equation in the ladder approximation is found in terms of a bi-orthogonal basis of the generalized Gilbert-Schmidt series for symmetric equations of the Fredholm type. According to this expansion, a new method of solving the Bethe-Salpeter equation and finding the mass spectrum is proposed. Methodological result of numerical solutions of equations with scalar interaction is presented. (author). 20 refs., 3 figs.

  8. Příčiny občanských válek v subsaharské Africe

    OpenAIRE

    Sniehotta, Michal

    2011-01-01

    Annotation: The Bachelor thesis deals with the civil war causes, especially in sub-Saharan Africa. The aim of this Bachelor thesis is to identify, summarize and systematize theories of the civil war causes and find out the main factors contributing to the war eruption in the area of the sub-Saharan Africa. The thesis is divided into two parts. In the first theoretic part the term "civil war" is defined and characterized in relation to other types of wars and forms of organized violence. This ...

  9. Reinterpretando la información de los vasos dinásticos de los Kaan ajawo’ob.

    Directory of Open Access Journals (Sweden)

    Pablo Alberto Mumary Farto

    2015-12-01

    Full Text Available Los conocidos como vasos dinásticos forman parte de una colección de alrededor de 17 vasos cerámicos caracterizados por la narrativa epigráfica que contienen en la cual se disponen listados de supuestos gobernantes de la dinastía Kaan desde su hipotético fundador. Tomando los trabajos de finales del siglo XX realizados por los investigadores Robicsek, Hales y Martin, reanalizaremos la información epigráfica contenida en dos vasos seleccionados proponiendo nuevas lecturas y, consecuentemente, presentando información que no había sido tenida en cuenta.

  10. Synthesis of organometallic hydroxides of titanium, vanadium, cobalt and chromium as precursors of thin films type MaOb

    International Nuclear Information System (INIS)

    Montero Villalobos, Mavis

    2001-01-01

    This study shows the results obtained from a general objective that was the synthesis and characterization of precursors of thin films of metallic oxides, two different routes of synthesis have been practiced: route molecular precursors and route Sol-Gel technic. In the first route one of the objectives of the investigation is to obtain a molecular precursor of material type M a O b a route of synthesis have been tried proved that involves anhydrous chlorides of the transition metals and linked R that are alcoxides of metal such as silicon, titanium and zirconium. In the second route the general objective to create thin films of metallic oxide has been maintained but the way to resolve the problem has changed, not giving so much emphasis to the molecular precursors as it was originally presented (this due mainly to its instability and difficulty of synthesis), but being supported in the sun-gel chemistry. It was started a new synthesis line through the sun-gel chemistry that is more versatile and simplifies the process in the film formation [es

  11. Gamma ray shielding properties of PbO-Li2O-B2O3 glasses

    International Nuclear Information System (INIS)

    Kumar, Ashok

    2017-01-01

    The mass attenuation coefficients have been measured in (0.6-x) PbO-x Li 2 O-0.40 B 2 O 3 (where 0≤ x≤0.25 mol%) glasses for photon energies of 356, 662, 1173 and 1332 keV in a narrow beam geometry with an overall scatter acceptance angle of 2.31°. The experimental results are found to be within 3% of their theoretical values. These coefficients were then used to obtain the values of mean free path, effective atomic number and electron density. The shielding properties of these glasses have also been compared among themselves in terms of their mean free path and radiation protection efficiency. The shielding properties prepared glasses have also been compared with standard concretes as well as with the standard shielding glasses. It is found that the prepared glasses are the better shielding substitute to the conventional concretes as well as other standard shielding glasses. The Pb 3 B 4 O 9 has been found to be the most effective shield. - Highlights: • Shielding efficiencies of PbO-B 2 O 3 -Li 2 O glasses have been compared. • Measurements have been done for 356, 662, 1173 and 1332 keV photon energies. • Experimental values have been found to be within 3% of their theoretical ones. • Pb 3 B 4 O 9 has been found to be the most effective shield.

  12. Gamma ray shielding properties of PbO-Li2O-B2O3 glasses

    Science.gov (United States)

    Kumar, Ashok

    2017-07-01

    The mass attenuation coefficients have been measured in (0.6-x) PbO-x Li2O-0.40 B2O3 (where 0≤ x≤0.25 mol%) glasses for photon energies of 356, 662, 1173 and 1332 keV in a narrow beam geometry with an overall scatter acceptance angle of 2.31°. The experimental results are found to be within 3% of their theoretical values. These coefficients were then used to obtain the values of mean free path, effective atomic number and electron density. The shielding properties of these glasses have also been compared among themselves in terms of their mean free path and radiation protection efficiency. The shielding properties prepared glasses have also been compared with standard concretes as well as with the standard shielding glasses. It is found that the prepared glasses are the better shielding substitute to the conventional concretes as well as other standard shielding glasses. The Pb3B4O9 has been found to be the most effective shield.

  13. Thermal and fragility studies on microwave synthesized K_2O-B_2O_3-V_2O_5 glasses

    International Nuclear Information System (INIS)

    Harikamalasree; Reddy, M. Sudhakara; Viswanatha, R.; Reddy, C. Narayana

    2016-01-01

    Glasses with composition xK_2O–60B_2O_3–(40-x) V_2O_5 (15 ≤ x ≤ 39 mol %) was prepared by an energy efficient microwave method. The heat capacity change (ΔC_p) at glass transition (T_g), width of glass transition (ΔT_g), heat capacities in the glassy (C_p_g) and liquid (C_p_l) state for the investigated glasses were extracted from Modulated Differential Scanning Calorimetry (MDSC) thermograms. The width of glass transition is less than 30°C, indicating that these glasses belongs to fragile category. Fragility functions [NBO]/(V_m"3T_g) and (ΔC_p/C_p_l)increases with increasing modifier oxide concentration. Increase in fragility is attributed to the increasing coordination of boron. Further, addition of K_2O creates NBOs and the flow mechanism involves bond switching between BOs and NBOs. Physical properties exhibit compositional dependence and these properties increase with increasing K_2O concentration. The observed variations are qualitatively analyzed.

  14. VizieR Online Data Catalog: Swift-UVOT obs. analysis of 29 SNe Ia (Brown+, 2017)

    Science.gov (United States)

    Brown, P. J.; Landez, N. J.; Milne, P. A.; Stritzinger, M. D.

    2017-10-01

    Swift/UVOT has observed over 500 SNe of all types in its 12 years of operation (see Brown+ 2015JHEAp...7..111B for a review of the first 10yrs). Most of the observations use six UV and optical filters. All photometry comes from the Swift Optical/Ultraviolet Supernova Archive (SOUSA; Brown+ 2014Ap&SS.354...89B) and is available at the Swift SN website and the Open Supernova Archive (Guillochon+ 2017ApJ...835...64G). (1 data file).

  15. Občanství, občanská společnost a národní stát. Potomci vietnamských imigrantů v ČR mezi aktivním a pasivním občanstvím

    OpenAIRE

    Dvořáková, Martina

    2011-01-01

    This paper analyzes the relationship between citizenship, civil society and nation state. It argues that citizenship is often viewed only in relation to the state and its active potential - arising from public activities mediated through communication media and civil society institutions - is neglected. As a result increasing number of permanent resident immigrants is in a long run denied full political rights which in turn endangers representative potential of liberal democracies. In the Cze...

  16. Sravněnije russkogo i češskogo etiketa dělovogo obščenija

    OpenAIRE

    ZAHRÁDKOVÁ, Zuzana

    2011-01-01

    The thesis focuses on the comparison of Russian and Czech business etiquette. It analyses various situations of the business meeting etiquette, when businessmen are encountered with their international partners. To every situation there are universal rules of business protocol assigned. These rules are completed with the national features of Russian and Czech etiquette. In the thesis, following situations are closely described: the process of greeting and introducing ? etiquette of speech, ha...

  17. Architects are also responsible if a building causes sickness; 'Architekten entscheiden mit, ob ein Gebaeude krank macht'

    Energy Technology Data Exchange (ETDEWEB)

    Schmid, W.

    2007-07-01

    In this interview with Professor Bjarne W. Olsen, president of the Indoor Air Congress held in 2008 in Copenhagen, the main topics dealt with at the conference are discussed. These included allergies, asthma and general health. In particular, architectural work of and the so-called Sick Building Syndrome are discussed. The effects of filters on air quality are looked at, as are energy-consumption aspects resulting from the use of filters. Architectural aspects of building and their effects on ventilation and air-conditioning requirements are examined. The influence of air quality on productivity is discussed, as are new developments and trends in air-conditioning. A further topic discussed is the release of harmful substances from building materials and furniture and how ventilation systems are to deal with this.

  18. Origins of Discrepancies Between Kinetic Rate Law Theory and Experiments in the Na2O-B2O3-SiO2 System

    International Nuclear Information System (INIS)

    McGrail, B. PETER; Icenhower, Jonathan P.; Rodriguez, Elsa A.; McGrail, B.P.; Cragnolino, G.A.

    2002-01-01

    Discrepancies between classical kinetic rate law theory and experiment were quantitatively assessed and found to correlate with macromolecular amorphous separation in the sodium borosilicate glass system. A quantitative reinterpretation of static corrosion data and new SPFT data shows that a recently advanced protective surface layer theory fails to describe the observed dissolution behavior of simple and complex silicate glasses under carefully controlled experimental conditions. The hypothesis is shown to be self-inconsistent in contrast with a phase separation model that is in quantitative agreement with experiments

  19. Stochastic forecasting of the geomagnetic field from the COV-OBS.x1 geomagnetic field model, and candidate models for IGRF-12

    DEFF Research Database (Denmark)

    Gillet, Nicolas; Barrois, Olivier; Finlay, Chris

    2015-01-01

    the ‘observations’ uncertainties in data assimilation schemes for the study of the outer core dynamics.We also present and illustrate a stochastic algorithm designed to forecast the geomagnetic field. The radial field at the outer core surface is advected by core motions governed by an auto-regressive process...... filter algorithm. We show that the envelope of forecasts includes the observed secular variation of the geomagnetic field over 5-year intervals, even in the case of rapid changes. In a purpose of testing hypotheses about the core dynamics, this prototype method could be implemented to build the ‘state...

  20. Klimatska pogojenost debelinskega prirastka dreves ob slovenskih visokogorskih alpskih jezerih = Climatic conditioning or radial increments of trees near Slovenian high-mountainous Alpine lakes

    Directory of Open Access Journals (Sweden)

    Darko Ogrin

    1998-01-01

    Full Text Available Analysed by means of standard dendrochronological and dendroclimatological processes were about 100 spruce and larch samples from the lake areas of Jezera on Planina pri Jezeru, Jezera v Ledvicah and Krnsko Jezero, all in the Julian Alps. Local chronologies mainly include the period from 1920 onwards. Correlation between radial increments and climatic data confirmed certain general anticipations about the relation between climate and increments in the upper forest-line zone, and concurrently exposed the specific influence of local, including non-climatic factors on the growth which can not be satisfactory comprised in dendroclimatological analysis.

  1. La santé dans les Caraïbes Contrer l'obésité par la diversité des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    à Saint-Kitts-et-Nevis en raison de la détérioration qui se produit sur les exploitations agricoles, de l'exposition à la lumière solaire, des températures élevées et de la manipulation inappropriée dans les commerces de détail ? • des techniques simples comme l'utilisation de pellicule de plastique peuvent tripler la durée de.

  2. LINEAR RELATION FOR WIND-BLOWN BUBBLE SIZES OF MAIN-SEQUENCE OB STARS IN A MOLECULAR ENVIRONMENT AND IMPLICATION FOR SUPERNOVA PROGENITORS

    Energy Technology Data Exchange (ETDEWEB)

    Chen Yang; Zhou Ping [Department of Astronomy, Nanjing University, Nanjing 210093 (China); Chu Youhua [Department of Astronomy, University of Illinois at Urbana-Champaign, 1002 West Green Street, Urbana, IL 61801 (United States)

    2013-05-20

    We find a linear relationship between the size of a massive star's main-sequence bubble in a molecular environment and the star's initial mass: R{sub b} Almost-Equal-To 1.22 M/M{sub Sun} - 9.16 pc, assuming a constant interclump pressure. Since stars in the mass range of 8 to 25-30 M{sub Sun} will end their evolution in the red supergiant phase without launching a Wolf-Rayet wind, the main-sequence wind-blown bubbles are mainly responsible for the extent of molecular gas cavities, while the effect of the photoionization is comparatively small. This linear relation can thus be used to infer the masses of the massive star progenitors of supernova remnants (SNRs) that are discovered to evolve in molecular cavities, while few other means are available for inferring the properties of SNR progenitors. We have used this method to estimate the initial masses of the progenitors of eight SNRs: Kes 69, Kes 75, Kes 78, 3C 396, 3C 397, HC 40, Vela, and RX J1713-3946.

  3. Ergonomic and macro ergonomic factors of the 'Ukrytie' shelter personnel safe activity; Ehrgonomicheskie i makroehrgonomicheskie faktory bezopasnoj deyatel'nosti personala ob'ekta 'Ukrytie'

    Energy Technology Data Exchange (ETDEWEB)

    Zhuravlev, G E; Kupnyj, V I; Danilov, V M; Vtornikov, V E [Rossijskaya akademiya nauk, Moskva (Russian Federation); Ob' ekt ' Ukrytie' , Chernobyl' [Ukraine

    1999-07-01

    Four actions are planned based upon this preliminary analysis of Human Factors technology applied to the Chernobyl Shelter activities, namely: 1. Provide expertise to and participate in all projects regarding the Shelter's future. 2. Conduct a detailed on-site survey of the current Shelter's situation. 3. Organize a business game (brain-storming) to shape the system of the Shelter's HF problems.

  4. EPR Structural Investigations on Ag2O-B2O3-CaO-P2O5 Vitreous System

    Directory of Open Access Journals (Sweden)

    Razvan Stefan

    2011-10-01

    Full Text Available Glass samples from vitreous system 1.5Ag2O98.5%[0.47B2O3(0.53-xCaOxP2O5] with 0  x  0.08 have been obtained by undercooled method. The magnetic species existing in glass powders have been highlighting by mean of electronic paramagnetic resonance (EPR. The resonance linewidth analysis reveal the interactions between magnetic ions.

  5. Odškodňování imateriálních újem sekundárních obětí.

    Czech Academy of Sciences Publication Activity Database

    Doležal, Tomáš

    2017-01-01

    Roč. 7, č. 2 (2017), s. 44-59 ISSN 1804-8137 Institutional support: RVO:68378122 Keywords : secondary victims * non- economic damage * emotional harm Subject RIV: AG - Legal Sciences OBOR OECD: Law http://www.ilaw.cas.cz/medlawjournal/index.php/medlawjournal/article/view/144

  6. On the problem of radiation hazard of fuel-containing materials in conversion of object <>; O probleme yadernoj opasnosti toplivosoderzhashchikh materialov pri preobrazovanii ob`ekta << Ukrytie >>.

    Energy Technology Data Exchange (ETDEWEB)

    Badovskij, V P; Dubar, L V; Shevchenko, S V [Myizhgaluzevij Naukovo-Tekhnyichnij Tsentr ` ` Ukrittya ` ` , Natsyional` na Akademyiya Nauk Ukrayini, Chornobil` (Ukraine)

    1994-12-31

    A problem of radiation hazard of fuel-containing materials (FCM) in object << Shelter >> is discussed. A conservative approach is applied. The approach was developed with allowance for a conservative estimation of fuel distribution in FCM and errors of the FCM hazard measurements. A version of 4PB accident development is proposed. According to this version there is considerable part of fuel in 305/2 room which forms FCM with average fuel concentration in this room over 25%.

  7. A technical alpha-active aerosol express measurement system for volumetric activity monitoring.; Metodika ehkspressnogo opredeleniya ob`emnoj aktivnosti tekhnogennykh al`fa-aktivnykh aehrozolej.

    Energy Technology Data Exchange (ETDEWEB)

    Badovskij, V P; Dubar, L V; Tokarevskij, V V; Shevchenko, S V; Shcherbina, V G [Myizhgaluzevij Naukovo-Tekhnyichnij Tsentr ` ` Ukrittya ` ` , Natsyional` na Akademyiya Nauk Ukrayini, Chornobil` (Ukraine)

    1994-12-31

    A possibility of a volumetric aerosol activity determination at the level of MPCa for {sup 239} Pu with a measurement time less than 60 minutes is discussed. For achieving maximum reduction of the natural background the virtual impactor and alpha-spectroscopy are proposed to be employed. Results of investigation of the virtual impactor parameters at the << Shelter >> and at the laboratory are described.

  8. VizieR Online Data Catalog: Low-mass stars in 25 Ori group and Orion OB1a (Suarez+, 2017)

    Science.gov (United States)

    Suarez, G.; Downes, J. J.; Roman-Zuniga, C.; Covey, K. R.; Tapia, M.; Hernandez, J.; Petr-Gotzens, M. G.; Stassun, K. G.; Briceno, C.

    2017-09-01

    The V, R, and I photometry used in this work was obtained from the Centro de Investigaciones de Astronomia (CIDA) Deep Survey of Orion (CDSO) catalog (Downes et al. 2014, Cat. J/MNRAS/444/1793), which was constructed by coadding the multi-epoch optical observations from the CIDA Variability Survey of Orion (CVSO; Briceno et al. 2005, Cat. J/AJ/129/907). The sensitivity limits of the CDSO covers the Low-Mass Star (LMS) and Brown Dwarf (BD) population of 25 Ori and its surroundings within the region 79.7°Eisenstein et al. 2011AJ....142...72E). The BOSS spectrograph has plates with 1000 fibers of 2'' diameter spanning a field of view of 3.0° in diameter and covering a wavelength range from 3560Å to 10400Å with a resolution of R=1560 at 3700Å and R=2650 at 9000Å (Gunn et al. 2006AJ....131.2332G; Smee et al. 2013AJ....146...32S). (4 data files).

  9. Role občanského sektoru při realizaci inovativních projektů a jejich přínos

    OpenAIRE

    Pešatová, Veronika

    2015-01-01

    The thesis addresses subject of innovative projects of NGOs in the field of parental support to return to the labour market after maternity leave. The main purpose of the thesis is to deliver a report about the role of the NGO in the process of implementation of innovative projects by using case studies. The objective of the thesis is to identify outcomes and level of innovation of these projects on the basis of testimonies of active participants. The theoretical part of the thesis describes ...

  10. Americký trávník jako cvičiště občanské ctnosti

    Directory of Open Access Journals (Sweden)

    Jan Hlávka

    2016-06-01

    Full Text Available This article seeks to refute the thesis of contemporary environmental criticism of the aesthetic origins of American lawn culture. In contrast to the prevailing view about the aesthetic autonomy of the perfect front lawn, the author traces the history of the concept back to the eighteenth-century philosophy of internal senses as reflected in the thought of Thomas Jefferson. The author seeks to demonstrate that in Jefferson’s processual conception of civic virtue (a foundation stone of democratic society, moral sense and the sense of beauty are entangled with the workings of cognitive capacities. Thus, the architectural and landscape designs of Jefferson (as well as of those of his successors, A. J. Downing, F. L. Olmsted, and F. S. Scott perform an aesthetic, moral, educative, and, above all, political function. The ideas discovered in Jefferson’s work are followed throughout the nineteenth-century industrialization and the spread of suburban housing to the emerging of post-war residential colonies, imposing ‘lawn politics’ by means of legal and social pressures.

  11. Viníci, či oběti? Rozpolcená paměť zemi nacistické osy v komparaci

    Czech Academy of Sciences Publication Activity Database

    Novotný, Lukáš

    2005-01-01

    Roč. 3, č. 1 (2005), s. 9 ISSN 1210-7050 R&D Projects: GA AV ČR IBS7028301 Institutional research plan: CEZ:AV0Z70280505 Keywords : collective memory * cultural memory * communicative memory Subject RIV: AO - Sociology, Demography

  12. Analýza působení Aliance nového občana ve slovenské politice

    Directory of Open Access Journals (Sweden)

    Lubomír Kopeček

    2006-12-01

    Full Text Available The article deals with political trajectories of New Civic Alliance (ANO in Slovakia. This liberal formation was founded by a media tycoon Pavol Rusko. Besides Rusko, the leadership of ANO includes several well-known personalities from sport, media, cultural and economic fields. In the September 2002 elections the Alliance received prominent support from Rusko’s media and secured 8 % of the votes. After the elections ANO became a member of the right-centre government coalition headed by Mikuláš Dzurinda. The relationships between ANO and other coalition partners were full of conflicts. In Autumn 2005 a big financial scandal affected the chairman Pavol Rusko, the party broke up and went to opposition. In the elections in 2006, the party gained only 1.4 % of the votes. The article tries to explain what the organisation model ANO was like and why its „life” was so short.

  13. "Občasné" a "dočasné" rezidence Jana Lucemburského v Lucembursku, Francii a Itálii

    Czech Academy of Sciences Publication Activity Database

    Benešovská, Klára

    2008-01-01

    Roč. 11, - (2008), s. 147-167 ISSN 0862-979X. [Dvory a rezidence ve středověku II. Praha, 18.10.2007-19.10.2007] Institutional research plan: CEZ:AV0Z80330511 Keywords : Gothic architecture * 14th century * John of Luxembourg * residences Subject RIV: AL - Art, Architecture, Cultural Heritage

  14. ReOBS: a new approach to synthesize long-term multi-variable dataset and application to the SIRTA supersite

    Science.gov (United States)

    Chiriaco, Marjolaine; Dupont, Jean-Charles; Bastin, Sophie; Badosa, Jordi; Lopez, Julio; Haeffelin, Martial; Chepfer, Helene; Guzman, Rodrigo

    2018-05-01

    A scientific approach is presented to aggregate and harmonize a set of 60 geophysical variables at hourly timescale over a decade, and to allow multiannual and multi-variable studies combining atmospheric dynamics and thermodynamics, radiation, clouds and aerosols from ground-based observations. Many datasets from ground-based observations are currently in use worldwide. They are very valuable because they contain complete and precise information due to their spatio-temporal co-localization over more than a decade. These datasets, in particular the synergy between different type of observations, are under-used because of their complexity and diversity due to calibration, quality control, treatment, format, temporal averaging, metadata, etc. Two main results are presented in this article: (1) a set of methods available for the community to robustly and reliably process ground-based data at an hourly timescale over a decade is described and (2) a single netCDF file is provided based on the SIRTA supersite observations. This file contains approximately 60 geophysical variables (atmospheric and in ground) hourly averaged over a decade for the longest variables. The netCDF file is available and easy to use for the community. In this article, observations are re-analyzed. The prefix re refers to six main steps: calibration, quality control, treatment, hourly averaging, homogenization of the formats and associated metadata, as well as expertise on more than a decade of observations. In contrast, previous studies (i) took only some of these six steps into account for each variable, (ii) did not aggregate all variables together in a single file and (iii) did not offer an hourly resolution for about 60 variables over a decade (for the longest variables). The approach described in this article can be applied to different supersites and to additional variables. The main implication of this work is that complex atmospheric observations are made readily available for scientists who are non-experts in measurements. The dataset from SIRTA observations can be downloaded at http://sirta.ipsl.fr/reobs.html (last access: April 2017) (Downloads tab, no password required) under https://doi.org/10.14768/4F63BAD4-E6AF-4101-AD5A-61D4A34620DE" target="_blank">https://doi.org/10.14768/4F63BAD4-E6AF-4101-AD5A-61D4A34620DE.

  15. Portable scintillation gamma-spectrometer for field measurement of radioactivity in extensive objects; Portativnyj stsintillyatsionnyj gamma-spektrometr dlya izmereniya radioaktivnosti ob''emnykh sred v polevykh usloviyakh

    Energy Technology Data Exchange (ETDEWEB)

    Besshejko, O. A. [Taras Shevchenko National University of Kyiv, Kyiv (Ukraine); Vishnevskij, I. N.; Denisenko, R. V.; Malyuk, I. A.; Petrosyan, Eh. E. [Institute for Nuclear Research, Kyiv (Ukraine); Karpenko, S. A.; Prijmak, V. N. [Ukrainian Association for Valves Industry, Dnepropetrovsk (Ukraine)

    2011-07-01

    The portable scintillated gamma-spectrometer for field measurement of radioactivity in the volume objects was designed. The crystal CdWO{sub 4} that has weak dependence of light yield from temperature in combination with PMT was applied as the gamma-rays detector. The design of the device provides the possibility for measuring radioactivity of the extensive objects in 4{pi}-geometry without background measurements. In this case the value of the efficiency needed for specific activity calculation in close approximation depends only from crystal geometry and density of measuring object and may be set as the device parameter without efficiency calibration procedure during the operation. The spectrometer does not have an auxiliary radio-active source and connecting cables in the composition. The smartphone operated under Windows Mobile is used as the control module. Bluetooth connection provides data exchange between smartphone and measurement head.

  16. ECA&D and E-OBS: High-resolution datasets for monitoring climate change and effects on viticulture in Europe

    OpenAIRE

    Photiadou Christiana; Fontes Natacha; Rocha Graça Antonio; Schrier Gerard van der

    2017-01-01

    Climate change and climate variability profoundly affect the production of wine. When facing a changing climate, the characteristics of wine produced in each region will change while the natural year-to-year variations in climate will increase variability of income for wine businesses and therefore affect profitability and economic resilience. The challenge posed to the viticulture community is thus to closely monitor these changes to be able to adapt business practices. The European Climate ...

  17. Radiolysis ob benzene, toluene and phenol aqueous solutions utilizing high energy electron beam; Radiolisis de benceno, tolueno y fenol en solucion acuosa utilizando haces de electrones

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Vanderhaghen, D E

    1999-12-31

    In a search for solutions to environmental pollution problems, radiolysis has proved to be an innovative technique for the removal of organic chemical pollutants in aqueous solution. Radiolysis has shown many advantages over many other techniques, as highly reactive species formed in water by ionizing radiation oxidize organic pollutants breaking down organic molecules to final simple products by oxidation to carbon dioxide and water in a complete oxidation. Our work consisted in doing some experiments in radiolysis with simulated polluted water to help us understand this technique and also develop, in a near future, a project for large scale water treatment. Our project includes the application of a Pelletron type Mexican made Electron Accelerator, which will affirm its capability and usefulness in performing investigation in this field of study. Experiments consisted in treating benzene, toluene and phenol aqueous solutions with an Electron Beam (0.48-0.55 MeV; 24 {mu}A). Two concentrations were used for each compound: 5 and 20 ppm (mg/l) for benzene and toluene; 10 and 50 ppm for phenol. Solutions were prepared with pure, mineral free water and two different p H (5.9), in order to study the effect of concentration and p H on removal efficiency, but avoiding the interference of radical scavengers. Results obtained coincide with the ones reported by Cooper, Nickelsen and Kurucz; highly efficient removal was achieved for benzene (>99.8%), toluene (>98.0%) and phenol (>88%). There was no visible important effect of p H on radiolysis efficiency for benzene nor toluene, phenol however, showed lower removal efficiency in acidic conditions. Concentration of aqueous solutions, nevertheless, did show an important effect at low doses for phenol. Results obtained reveal the importance of this technique in water pollution control and water remedial as expressed by Cooper, Nickelsen and Kurucz, who have studied radiolysis of organic compounds and apply this technique in water site remedial with a mobile Electron Beam facility. (Author)

  18. OPTIMIZACIJA STROŠKOV PROIZVODNJE S STALIŠČA PORABE ENERGENTOV V OBRATU MEKOM ROGATEC IN MEKOM BISTRICA OB SOTLI

    OpenAIRE

    Berk, Avgust

    2010-01-01

    Diplomska naloga zajema analizo porabe stisnjenega zraka,elektrike,plina in vode.Operativno delo je potekalo na zbiranju,urejanju in razvrščanju podatkov po posameznih energentih v obratu Mekom Rogatec.Podane so šipke točke(izgube)porabe posameznih energentov.Prikazani so konkretni ukrepi, s katerimi so bili ti prihranki energentov dejansko doseženi v praksi.Vzporedno s to nalogo je potekal tudi projekt zmanjšanja in urejanja, to je ločenega zbiranja vseh komunalnih odpadkov v takšnem obratu....

  19. Transformation kinetics of chlorinated ethenes by Methylosinus trichosporium OB3b and detection of unstable epoxides by on-line gas chromatography

    NARCIS (Netherlands)

    van Hylckama Vlieg, Johan. E.T.; Koning, Wim de; Janssen, Dick B.

    A rapid and accurate method for the determination of transformation kinetics of volatile organic substrates was developed. Concentrations were monitored by on-line gas chromatographic analysis of the headspace of well-mixed incubation mixtures. With this method, the kinetics of transformation of a

  20. En toutes franchises : de la capacité d'obéissance à la capacité d'initiative

    OpenAIRE

    Allam, Délila

    2011-01-01

    Coordination and franchise: from an obedience to an capacity of initiative Summary Franchise networks are a form of collective entrepreneurship that bring together entrepreneurs spread over an economic territory who choose to act in a concerted and consistent manner with regard to the expectations of consumers. This hybrid form of coordination is different from both the market and the firm and responds to a new economic environment. In this paper, I seek to analyze this phenomenon byexamining...

  1. Effect ob Bacillus Thuringiensis Aegypti and Gamma Irradiation on the Ultrastructure of the Mid Gut of Arenipses Sabella Larvae Hampson (pyralidae:Lepidoptera)

    International Nuclear Information System (INIS)

    Mikhaiel, A.A.; Abul Fadl, H.A.A.

    2011-01-01

    Laboratory experiments were carried out to investigate the effect of Egyptian Bacillus thuringiensis aegypti on the third larval instar of Arenipses sabella at five concentrations (0.125, 0.25, 0.50, 1 and 2 g/100 ml water). The results showed that the percentages of larval mortality were increased by increasing the applied concentration. A combination of irradiation and B. thuringiensis led to higher mortality in F1 progeny of A. sabella while F1 progeny of irradiated parents with 175 Gy was more susceptible to B. thuringiensis than that of non-irradiated parents. The LC 50 was 0.721 g/100 ml for F1 progeny of non-irradiated parents but 0.237 g/100 ml for those of irradiated parents. There was an inverse relation between the concentration and emergence percentage in non-irradiated larvae and there was a great reduction in the emergence of F1 progeny of irradiated parents as compared to non-irradiated parents. Such reduction was increased by applying a higher concentration of B. thuringiensis. The histopathological studies using ultrastructure microscopy were carried out on the mid gut of the 3rd larval instar after the treatment with LC 50 of the agerin, F1 larvae resulted from irradiated parents with 125 Gy and combined effect of both treatments. Electron microscope observations revealed that the most characteristic effects were mid gut columnar cell vacuolisation, microvilli damages, epithelium cell contents passing into the mid gut lumen and finally the cell death. It could be concluded that the integrated of inherited sterility technique and B. thuringiensis application gave a good control result against A. sabella.

  2. O proměnách interpretace občanství EU v judikatuře Evropského soudního dvora

    Czech Academy of Sciences Publication Activity Database

    Hamerník, Pavel

    2007-01-01

    Roč. 16, č. 1 (2007), s. 3-9 ISSN 1802-3843 R&D Projects: GA ČR GA407/06/1467 Institutional research plan: CEZ:AV0Z70680506 Keywords : European Court of Justice * European Union Subject RIV: AG - Legal Sciences

  3. Rozvoj občanské společnosti a demokracie pohledem mladých Čechů

    Czech Academy of Sciences Publication Activity Database

    Basl, Josef; Straková, Jana; Veselý, A.

    2009-01-01

    Roč. 59, č. 4 (2009), s. 365-379 ISSN 0031-3815 R&D Projects: GA ČR GA403/08/0109 Institutional research plan: CEZ:AV0Z70280505 Keywords : civic attitudes * civic activities * secondary school students Subject RIV: AO - Sociology, Demography

  4. Multiphase formation of the Obří důl polymetallic skarn deposit, West Sudetes, Bohemian Massif: geochemistry and Re–Os dating of sulfide mineralization

    Czech Academy of Sciences Publication Activity Database

    Veselovský, F.; Ackerman, Lukáš; Pašava, J.; Žák, Karel; Haluzová, Eva; Creaser, R. A.; Dobeš, P.; Erban, V.; Tásler, R.

    2018-01-01

    Roč. 53, č. 5 (2018), s. 665-682 ISSN 0026-4598 R&D Projects: GA ČR GA13-15390S Institutional support: RVO:67985831 Keywords : Bohemian Massif * polymetallic skarn deposit * West Sudetes * arsenopyrite * Re–Os geochronology Subject RIV: DB - Geology ; Mineralogy OBOR OECD: Geology Impact factor: 3.396, year: 2016

  5. Parsec-scale Variations in the "7Li i/"6Li i Isotope Ratio Toward IC 348 and the Perseus OB 2 Association

    International Nuclear Information System (INIS)

    Knauth, D. C.; Taylor, C. J.; Federman, S. R.; Ritchey, A. M.; Lambert, D. L.

    2017-01-01

    Measurements of the lithium isotopic ratio in the diffuse interstellar medium from high-resolution spectra of the Li i λ 6708 resonance doublet have now been reported for a number of lines of sight. The majority of the results for the "7Li/"6Li ratio are similar to the solar system ratio of 12.2, but the line of sight toward o Per, a star near the star-forming region IC 348, gave a ratio of about two, the expected value for gas exposed to spallation and fusion reactions driven by cosmic rays. To examine the association of IC 348 with cosmic rays more closely, we measured the lithium isotopic ratio for lines of sight to three stars within a few parsecs of o Per. One star, HD 281159, has "7Li/"6Li ≃ 2 confirming production by cosmic rays. The lithium isotopic ratio toward o Per and HD 281159 together with published analyses of the chemistry of interstellar diatomic molecules suggest that the superbubble surrounding IC 348 is the source of the cosmic rays.

  6. Le surpoids, l'obésité et le contrôle glycémique chez les diabétiques ...

    African Journals Online (AJOL)

    utilisation et du stockage des sucres apportés par l'alimentation, sa prise en charge est ... l'organisation mondiale de santé (OMS), Le contrôle glycémique a été effectué par l'analyse sanguine de l'Hémoglobine glycosylée et de la Glycémie à jeun.

  7. Parsec-scale Variations in the {sup 7}Li i/{sup 6}Li i Isotope Ratio Toward IC 348 and the Perseus OB 2 Association

    Energy Technology Data Exchange (ETDEWEB)

    Knauth, D. C. [Woodlawn High School, 1801 Woodlawn Drive, Baltimore, MD 21207 (United States); Taylor, C. J.; Federman, S. R. [Department of Physics and Astronomy, University of Toledo, Toledo, OH 43606 (United States); Ritchey, A. M. [Department of Astronomy, University of Washington, Seattle, WA, 98195 (United States); Lambert, D. L., E-mail: knauth_dc2@hotmail.com, E-mail: steven.federman@utoledo.edu, E-mail: cjtaylor@astro.umd.edu, E-mail: aritchey@astro.washington.edu, E-mail: dll@astro.as.utexas.edu [Department of Astronomy, University of Texas, Austin, TX 78712 (United States)

    2017-01-20

    Measurements of the lithium isotopic ratio in the diffuse interstellar medium from high-resolution spectra of the Li i λ 6708 resonance doublet have now been reported for a number of lines of sight. The majority of the results for the {sup 7}Li/{sup 6}Li ratio are similar to the solar system ratio of 12.2, but the line of sight toward o Per, a star near the star-forming region IC 348, gave a ratio of about two, the expected value for gas exposed to spallation and fusion reactions driven by cosmic rays. To examine the association of IC 348 with cosmic rays more closely, we measured the lithium isotopic ratio for lines of sight to three stars within a few parsecs of o Per. One star, HD 281159, has {sup 7}Li/{sup 6}Li ≃ 2 confirming production by cosmic rays. The lithium isotopic ratio toward o Per and HD 281159 together with published analyses of the chemistry of interstellar diatomic molecules suggest that the superbubble surrounding IC 348 is the source of the cosmic rays.

  8. Mixed-Alkali Effect in Li2O-Na2O-K2O-B2O3 Glasses: Infrared and Optical Absorption Studies

    Science.gov (United States)

    Samee, M. A.; Edukondalu, A.; Ahmmad, Shaik Kareem; Taqiullah, Sair Md.; Rahman, Syed

    2013-08-01

    The mixed-alkali effect (MAE) has been investigated in the glass system (40 - x)Li2O- xNa2O-10K2O-50B2O3 (0 mol% ≤ x ≤ 40 mol%) through density, modulated differential scanning calorimetry (DSC), and optical absorption studies. From the absorption studies, the values of the optical band gap ( E opt) for direct transition and Urbach energy (Δ E) have been evaluated. The values of E opt and Δ E show nonlinear behavior with the compositional parameter. The density and glass-transition temperature of the present glasses also show nonlinear variation, supporting the existence of MAE. The infrared (IR) spectra of the glasses reveal the presence of three- and four-coordinated boron atoms. The specific vibrations of Li-O, Na-O, and K-O bonds were observed in the present IR study.

  9. Nekateri razmisleki ob preučevanju domačinskih razumevanj nacije v dolini zgornje Kolpe po vzpostavitvi slovenskohrvaške državne meje

    OpenAIRE

    Knežević Hočevar, Duška

    2000-01-01

    Danes so v družboslovju vse bolj v ospredju teme, ki se nanašajo na specifično evropsko situacijo po »padcu Berlinskega zidu«, na nastanek novih mednarodnih meja. Tudi avtorica pričujočega prispevka poseže v tak prostor: v obmejni pas, ki ga obeležuje nova mednarodna meja med Slovenijo in Hrvaško (1991). Besedilo nas na kratko seznani z nekaterimi pomembnejšimi izsledki njenega terenskega raziskovanja, v katerem je v ospredju dolinsko (samo)razumevanje nacionalnih identitet in upravljanje s t...

  10. Vliv masmédií na politické myšlení a jednání občanů

    OpenAIRE

    Petrová, Dita

    2008-01-01

    This thesis analyses the emergence and history of modern Czech media and characterizes public opinion and political culture in the context of both positive and negative influences of media on voters. It points out the important role of journalists in the world of media and the function of "Ethic Codex of Journalists". An important part of the thesis deals with research on media influence on political thought and citizens' behaviour with a reference to Czech parliamentary elections of2006.

  11. Electrical mobility of silver ion in Ag2O-B2O3-P2O5-TeO2 glasses.

    Science.gov (United States)

    Sklepić, Kristina; Vorokhta, Maryna; Mošner, Petr; Koudelka, Ladislav; Moguš-Milanković, Andrea

    2014-10-16

    The effect of adding TeO(2) into (100 - x)[0.5Ag(2)O - 0.1B(2)O(3) - 0.4P(2)O(5)] - xTeO(2), with 0-80 mol % TeO(2) glass, on the structural changes and electrical properties has been investigated. DSC and thermodilatomery were used to study their thermal behavior, structure was studied by Raman spectroscopy, and electrical properties have been studied by impedance spectroscopy over a wide temperature and frequency range. The introduction of TeO(2) as a third glass former to the glass network causes the structural transformation from TeO(3) (tp) to TeO(4) (tbp) which contributes to the changes in conductivity. The glasses with low TeO(2) content show only a slow decrease in dc conductivity with addition of TeO(2) due to the increase of the number of nonbridging oxygens, which increases the mobility of Ag(+) ions. The steep decrease in conductivity for glasses containing more than 40 mol % TeO(2) is a result of decrease of the Ag(2)O content and stronger cross-linkage in glass network through the formation of more Te-(eq)O(ax)-Te bonds in TeO(4) tbp units. The glasses obey ac conductivity scaling with respect to temperature, implying that the dynamic process is not temperature dependent. On the other hand, the scaling of the spectra for different glass compositions showed the deviations from the Summerfield scaling because of the local structural disorder which occurs as a result of the structural modifications in the tellurite glass network.

  12. A High Angular Resolution Survey of Massive Stars in Cygnus OB2: Results from the Hubble Space Telescope Fine Guidance Sensors

    Science.gov (United States)

    2014-02-01

    Horch et al. 2006; Nelan et al. 2012). At these separations we are sampling systems where the components would evolve independently of each other but are...online journal.) the shape of an S-curve is slightly broadened for redder targets ( Horch et al. 2006). We chose calibrators whose colors are within ±0.2...Kudritzki, R. P., & Villamariz, M. R. 2001, A&A, 366, 623 Horch , E. P., Franz, O. G., Wasserman, L. H., & Heasley, J. N. 2006, AJ, 132, 836 Kennedy, M

  13. Generační rozdíly ve výživě obézních

    OpenAIRE

    Lochmanová, Aneta

    2014-01-01

    The theme of this bachelor's thesis is the problematic of obesity. In the theoretical part there are summarized following topics: classification of obesity, diagnostic procedures, ethiopathogenesis, the complications connected with obesity and the treatment methods. The final part of this thesis is focused on the prevention and the nutrition in particular periods of human life. The main emphasis is put on the practical part, where eating habits of obese patients of various generations are com...

  14. Abrasiveness and hardness of rocks of Cretaceous deposits of Chechen-Ingushetiya. Ob abrazivnosti i tverdosti gornykh porod melovykh otlozhenii Checheno-Ingushetii

    Energy Technology Data Exchange (ETDEWEB)

    Trofimenko, Yu.P.

    1981-01-01

    Presented are results of studies of the abrasiveness and hardness of core material taken from Upper Cretaceous deposits in the process of drilling deep boreholes in the areas of Chechen-Ingushetiya. Based on the studies it is established that the abrasiveness of rock is mainly influenced by the coarseness of the mineral grains in the rock, their mineralogical composition, and the composition of the cement. Given is a system of clasification of the investigated core material with respect to abrasiveness and hardness.

  15. České a československé oběživo v hospodářsko-právních souvislostech

    OpenAIRE

    Maránek, Pavel

    2010-01-01

    Czech and Czechoslovak Currency within Economic and Legal Context This diploma thesis is dedicated to currency throughout the whole history of Czechoslovakia. Currency and its legal definition is a very important question not only for country's economy but also for each individual in the society. Above all, the phenomenon of monetary reforms, which have been mentioned very frequently by my grand-parents within the context of monetary reform put into life in 1953, encouraged me in seeking to d...

  16. On the Time of the Intellect: The Interpretation of De Anima 3.6 (43ob 7-20) in Renaissance and Early Modern Italian Philosophy.

    Science.gov (United States)

    Dubouclez, Olivier

    2015-01-01

    This article argues that an original debate over the relationship between time and the intellect took place in Northern Italy in the second half of the sixteenth century, which was part of a broader reflection on the temporality of human mental acts. While human intellectual activity was said to be 'above time' during the Middle Ages, Renaissance scholars such as Marcantonio Genua (1491-1563), Giulio Castellani (1528-1586), Antonio Montecatini (1537-1599) and Francesco Piccolomini (1520-1604), greatly influenced by the Simplician and Alexandrist interpretations of Aristotle's works, proposed alterna- tive conceptions based on the interpretation of De anima 3.6 (430b 7-20) according to which intellectual acts happen in a both 'undivided' and 'divisible time'. In order to explain Aristotle's puzzling claim, they were led to conceive of intellectual activity as a process similar to sensation, corresponding to a certain lapse of time (Castellani), an instant (Montecatini), or a mix of instantaneousness and concrete duration (Piccolomini), depending on their theoretical options.

  17. COMMENTARY TO THE ARTICLE BY R.F. TEPAEV, O.B. GORDEEVA, V.V. BOTVINYEVA, O.K. BOTVINYEV “HEMORRHAGIC SYNDROME IN BABIES”

    Directory of Open Access Journals (Sweden)

    R. F. Tepaev

    2015-01-01

    Full Text Available Гемостаз представляет собой сбалансированную систему про- и антикоагуляционных механизмов, направленную на предупреждение кровотечений при повреждении кровеносных сосудов, с одной стороны, и неконтролируемого тромбообразования — с другой.

  18. Stimulation cérébrale profonde hypothalamique pour l'obésité chez le primate non humain : Une approche préclinique.

    OpenAIRE

    Torres , Napoleon

    2008-01-01

    Abstract Object: Deep brain stimulation (DBS) has become an effective therapy in a variety of brain disorders. Recently, Hypothalamic DBS in cases of chronic intractable cluster headache has revived the interest in this region, which is also well-known to be involved in food intake and energy balance regulation. In the other hand, risks and problems related with implantation in this area has raised several questions regarding the safety of this approach. In this study, the authors proposed an...

  19. Radiolysis ob benzene, toluene and phenol aqueous solutions utilizing high energy electron beam; Radiolisis de benceno, tolueno y fenol en solucion acuosa utilizando haces de electrones

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Vanderhaghen, D.E

    1998-12-31

    In a search for solutions to environmental pollution problems, radiolysis has proved to be an innovative technique for the removal of organic chemical pollutants in aqueous solution. Radiolysis has shown many advantages over many other techniques, as highly reactive species formed in water by ionizing radiation oxidize organic pollutants breaking down organic molecules to final simple products by oxidation to carbon dioxide and water in a complete oxidation. Our work consisted in doing some experiments in radiolysis with simulated polluted water to help us understand this technique and also develop, in a near future, a project for large scale water treatment. Our project includes the application of a Pelletron type Mexican made Electron Accelerator, which will affirm its capability and usefulness in performing investigation in this field of study. Experiments consisted in treating benzene, toluene and phenol aqueous solutions with an Electron Beam (0.48-0.55 MeV; 24 {mu}A). Two concentrations were used for each compound: 5 and 20 ppm (mg/l) for benzene and toluene; 10 and 50 ppm for phenol. Solutions were prepared with pure, mineral free water and two different p H (5.9), in order to study the effect of concentration and p H on removal efficiency, but avoiding the interference of radical scavengers. Results obtained coincide with the ones reported by Cooper, Nickelsen and Kurucz; highly efficient removal was achieved for benzene (>99.8%), toluene (>98.0%) and phenol (>88%). There was no visible important effect of p H on radiolysis efficiency for benzene nor toluene, phenol however, showed lower removal efficiency in acidic conditions. Concentration of aqueous solutions, nevertheless, did show an important effect at low doses for phenol. Results obtained reveal the importance of this technique in water pollution control and water remedial as expressed by Cooper, Nickelsen and Kurucz, who have studied radiolysis of organic compounds and apply this technique in water site remedial with a mobile Electron Beam facility. (Author)

  20. Meze a možnosti občanské participace v komunitním plánování

    OpenAIRE

    Čech, Petr

    2011-01-01

    Name of Dissertation: Civil Participation in Social Planning: Limits and Possibilities Name: Petr Čech Field of Study: Sociology Leader of Dissertation: PhDr. Richard Růžička, CSc. Keywords: citizen, community, participation, social service, social/community planning The dissertation focused on participative element of democracy. The author aimed at the way of participation in the selected districts and attempted to analyze the way of communication of the events relating to the social plannin...

  1. Inflammation et immunité : implications dans l’obésité et le diabète de type 2

    Directory of Open Access Journals (Sweden)

    Akhtar Khan Naim

    2006-09-01

    Full Text Available The evidences have been increasingly accumulated on the implication of inflammatory mediators like tumor necrosis factor-α (TNF-α and interleukin-6 (IL-6 in the pathological states related to insulin resistance like obesity, type 2 diabetes and atherosclerosis. There seems a link between insulin resistance and these pro-inflammatory agents, secreted by macrophages and adipocytes. Th (helper cells are differentiated into either Th1 or Th2 phenotypes. It is generally considered that Th1 phenotype is pro-inflammatory whereas Th2 phenotype exerts anti-inflammatory (protective effects. The upregulation of Th1 phenotype may aggravate these pathologies. One of the adipokines, i.e., adiponectin, and insulin act as anti-inflammatory agents. Insulin also favours the differentiation of Th cells into Th2 phenotype. TNF-α and IL-6 might counter balance the action of insulin by interfering with insulin receptor signalling in these pathological situations. The agonists of PPARα and PPARγ, and n-3 polyunsaturated fatty acids may exert an anti-inflammatory effect by shifting Th1/Th2 balance to Th2 phenotype. The factors, implicated in the secretion of inflammatory mediators are not well known, though the role of glucose-induced oxidative stress has been underlined. In this article, we shed light on the cross-talk between pro- and anti-inflammatory agents in these patho-physiological states related to insulin resistance.

  2. Study of a scintillation neutron detector of 1OB+ZnS(Ag) as alternative to the 3He detectors: model MCNPX and validation

    International Nuclear Information System (INIS)

    Guzman G, K. A.; Gallego D, E.; Lorente F, A.; Ibanez F, S.; Vega C, H. R.; Mendez V, R.; Gonzalez, J. A.

    2015-10-01

    Using Monte Carlo methods with the code MCNPX, was estimated the response of a scintillation neutron detector of Zn S(Ag) with a mixture of 10 B high enrichment. The detector consists of four plates of Poly (methyl methacrylate) (PMMA) and five layers of ∼0, 017 cm 10 B+ZnS(Ag) in contact with PMMA. The naked detector response was calculated and with different thicknesses of high density polyethylene moderator, for 29 monoenergetic sources and for sources of 241 AmBe and 252 Cf of neutrons. In these calculations the reactions 10 B(n,α) 7 Li and neutron fluence in the sensitive area of detector 10 B+ZnS(Ag) were estimated. Measurements were performed in the Laboratory of Neutron Measurement to quantify detections in counts per second to a neutron source of 252 Cf to 200 cm on the bench, modeling with MCNPX, these measures were compared to validate the model and the Zn S(Ag) efficiency of α detection was estimated. Calculations in the LPN-CIEMAT were realized. Starting from the validation new models were carried out with geometries that improve the detector response, trying reaching the detection of 2, 5 cps-ng of 252 Cf comparable requirement for responding to the installed equipment of 3 He in the radiation portal monitor. This type of detector can be considered an alternative to detectors of 3 He for detecting special nuclear material. (Author)

  3. Coupled effects of methane monooxygenase and nitrogen source on growth and poly-β-hydroxybutyrate (PHB) production of Methylosinus trichosporium OB3b.

    Science.gov (United States)

    Zhang, Tingting; Zhou, Jiti; Wang, Xiaowei; Zhang, Yu

    2017-02-01

    The coupled effects of nitrogen source and methane monooxygenase (MMO) on the growth and poly-β-hydroxybutyrate (PHB) accumulation capacity of methanotrophs were explored. The ammonia-supplied methanotrophs expressing soluble MMO (sMMO) grew at the highest rate, while N 2 -fixing bacteria expressing particulate MMO (pMMO) grew at the lowest rate. Further study showed that more hydroxylamine and nitrite was formed by ammonia-supplied bacteria containing pMMO, which might cause their slightly lower growth rate. The highest PHB content (51.0%) was obtained under nitrogen-limiting conditions with the inoculation of nitrate-supplied bacteria containing pMMO. Ammonia-supplied bacteria also accumulated a higher content of PHB (45.2%) with the expression of pMMO, while N 2 -fixing bacteria containing pMMO only showed low PHB production capacity (32.1%). The maximal PHB contents of bacteria expressing sMMO were low, with no significant change under different nitrogen source conditions. The low MMO activity, low cell growth rate and low PHB production capacity of methanotrophs continuously cultivated with N 2 with the expression of pMMO were greatly improved in the cyclic NO 3 - N 2 cultivation regime, indicating that long-term deficiency of nitrogen sources was detrimental to the activity of methanotrophs expressing pMMO. Copyright © 2016. Published by Elsevier B.V.

  4. Randomized controlled trial of a 12-month computerized mindfulness-based intervention for obese patients with binge eating disorder: The MindOb study protocol.

    Science.gov (United States)

    Ruffault, Alexis; Carette, Claire; Lurbe I Puerto, Kàtia; Juge, Nicolas; Beauchet, Alain; Benoliel, Jean-Jacques; Lacorte, Jean-Marc; Fournier, Jean F; Czernichow, Sébastien; Flahault, Cécile

    2016-07-01

    Mindfulness-based interventions for healthy behaviors such as exercise and dietary modifications have aroused growing interest. This study aims to test the effectiveness of a mindfulness-based intervention for the reduction of impulsive eating and the improvement of motivation to exercise among obese individuals. One-hundred and twenty obese outpatients, aged 18 to 65years, diagnosed with a binge eating disorder, will be randomly assigned to one of the three following groups: mindfulness practice, sham meditation, or treatment as usual control. The tested intervention consists of a 1-year computerized mindfulness-based program. Mindfulness sessions are audio recordings that the patients are asked to listen to, 10min every day. Self-reported questionnaires measuring impulsive eating, motivation to exercise, physical activity level, mood, and mindfulness skills are filled in at baseline, 1, 6, and 12months. Physical activity, calories consumption, and biomarkers are measured with more objective measurement tools at baseline, 6months and 12months. Mindfulness, as both a de-automation element and as a moderator of motivation to exercise, can lead to the reduction of impulsive eating and also to an increase in levels of physical activity. These effects could cause weight loss in obese patients suffering from binge eating disorder. clinicaltrials.gov: NCT02571387. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Práce jako řešení? Strategie obživy osamělých matek v ČR

    Czech Academy of Sciences Publication Activity Database

    Dudová, Radka

    2009-01-01

    Roč. 45, č. 4 (2009), s. 753-784 ISSN 0038-0288 R&D Projects: GA MPS 1J034/05-DP2; GA AV ČR KJB700280503; GA AV ČR IAA700280804; GA AV ČR 1QS700280503 Institutional research plan: CEZ:AV0Z70280505 Keywords : Lone mothers * poverty * work Subject RIV: AO - Sociology, Demography Impact factor: 0.562, year: 2009

  6. The effect on phase separation of the oxidation state of molybdenum in a Na2O-B2O3-SiO2 glass

    International Nuclear Information System (INIS)

    Kawamoto, Y.; Clemens, K.; Tomozawa, M.; Warden, J.T.

    1981-01-01

    The effect of oxidation state on phase separation was studied for 13Na 2 O, 49B 2 O 3 , 38SiO 2 (mol%) glasses containing 1 mol% Mo oxide. The glasses were melted under various conditions to vary the oxidation states of Mo ions. The oxidation states of Mo ions were determined by chemical analysis and ESR. The crystallisation tendency, the immiscibility temperature, and the phase separation morphology of the glasses were examined by DTA, x-ray diffraction, opalescence method, and replica electron microscopy. Glasses containing Mo 4+ ions have a great tendency to precipitate MoO 2 crystals. The immiscibility temperature of glass goes through a minimum when the oxidation states of Mo ions are changed. It was suggested that there is an optimum oxidation state to prevent crystallisation and to suppress the phase separation tendency of this system. (author)

  7. Kontroverzní témata v hodinách občanské výchovy

    OpenAIRE

    Marková, Markéta

    2007-01-01

    The topic of this thesis is "Controversial issues in classes of Civics." In the theoretical part I first deal with goals and contents of Civics subject from point of view of different curricular documents. I further address the definition and meaning of the words controversy and controversial. I determine basic conditions the issue has to meet to become controversial. In the third section I answer the following question: why it is important to discuss controversial issues at school. I present...

  8. Microbiote intestinal et obésité : impact des lipides bioactifs issus du système endocannabinoïde

    Directory of Open Access Journals (Sweden)

    Cani Patrice D.

    2016-05-01

    Full Text Available De nombreux travaux ont associé le microbiote intestinal au développement de désordres métaboliques. Parmi les mécanismes potentiellement impliqués dans le dialogue bactéries-hôtes, le système endocannabinoïde (eCB et ses lipides bioactifs jouent un rôle important. Nos travaux suggèrent l’existence d’un dialogue à double-sens entre l’organisme et les bactéries : le tissu adipeux contrôlerait la fonction barrière de l’intestin; et les bactéries de l’intestin seraient capables de contrôler le métabolisme du tissu adipeux.

  9. Un algorithme efficace d'intégration plastique pour un matériau obéissant au critère anisotrope de Hill

    Science.gov (United States)

    Titeux, Isabelle; Li, Yuming M.; Debray, Karl; Guo, Ying-Qiao

    2004-11-01

    This Note deals with an efficient algorithm to carry out the plastic integration and compute the stresses due to large strains for materials satisfying the Hill's anisotropic yield criterion. The classical algorithm of plastic integration such as 'Return Mapping Method' is largely used for nonlinear analyses of structures and numerical simulations of forming processes, but it requires an iterative schema and may have convergence problems. A new direct algorithm based on a scalar method is developed which allows us to directly obtain the plastic multiplier without an iteration procedure; thus the computation time is largely reduced and the numerical problems are avoided. To cite this article: I. Titeux et al., C. R. Mecanique 332 (2004).

  10. Účetní a daňový režim občanského sdružení

    OpenAIRE

    VOMELOVÁ, Petra

    2010-01-01

    The aim of this theses is analysis of accounting`s conditions and links to tax law, the needs and requirements of accounting in civil associations. For the implementation of the chosen problem into practice was selected civic association OS Stavba ČR. The work focuses on legislative conditions in areas of tax, i.e.. income tax, value added tax, road-traffic tax, real estate tax and gift, inheritance and real estate-tranfer tax. Each tax was analyzed in three views to make them well-arranged: ...

  11. Parsec-scale Variations in the 7Li I/6Li I Isotope Ratio Toward IC 348 and the Perseus OB 2 Association

    Science.gov (United States)

    Knauth, D. C.; Taylor, C. J.; Ritchey, A. M.; Federman, S. R.; Lambert, D. L.

    2017-01-01

    Measurements of the lithium isotopic ratio in the diffuse interstellar medium from high-resolution spectra of the Li I λ6708 resonance doublet have now been reported for a number of lines of sight. The majority of the results for the 7Li/6Li ratio are similar to the solar system ratio of 12.2, but the line of sight toward o Per, a star near the star-forming region IC 348, gave a ratio of about two, the expected value for gas exposed to spallation and fusion reactions driven by cosmic rays. To examine the association of IC 348 with cosmic rays more closely, we measured the lithium isotopic ratio for lines of sight to three stars within a few parsecs of o Per. One star, HD 281159, has 7Li/6Li ≃ 2 confirming production by cosmic rays. The lithium isotopic ratio toward o Per and HD 281159 together with published analyses of the chemistry of interstellar diatomic molecules suggest that the superbubble surrounding IC 348 is the source of the cosmic rays. Based on observations obtained with the Hobby-Eberly Telescope, which is a joint project of the University of Texas at Austin, the Pennsylvania State University, Ludwig-Maximilians-Universität München, and Georg-August-Universität Göttingen.

  12. Svatební obřad v Minangkabau: reprezentace mechanismů matrilineární organizace trans-lokální komunity

    Czech Academy of Sciences Publication Activity Database

    Pflegerová, Mariana

    2009-01-01

    Roč. 96, č. 1 (2009), s. 49-70 ISSN 0009-0794 R&D Projects: GA ČR GA404/07/1304 Institutional research plan: CEZ:AV0Z90580513 Keywords : Indonesia * women * kinship * matrilineal systems * ritual * marriage rituals Subject RIV: AC - Archeology, Anthropology, Ethnology

  13. El abrigo de Martinarri (Obécuri, Treviño: una ocupación del Tardiglaciar en la Cuenca Alta del Ebro

    Directory of Open Access Journals (Sweden)

    Alday, Alfonso

    2012-12-01

    Full Text Available We present recently discovered Martinarri’s site, in Treviño. The initial excavations have shown that it was occupied during the transition from Pleistocene to Holocene, providing information of a largely unknown episode in the Upper Ebro and in the interior of the Iberian peninsula. The text provides an initial assessment of the stratigraphic sequence and the materials recovered. Along with carbon-14 data (unpublished, we propose an initial interpretation of the dynamics of occupation of the site. Also, the nature of the period to which it refers, requires a review of currently available knowledge and reflection on its characterization.

    Presentamos el yacimiento de Martinarri, recientemente descubierto en Treviño. Los iniciales trabajos de excavación han evidenciado ocupaciones en el tránsito del Pleistoceno al Holoceno que llenan de contenido un episodio cultural muy desconocido en el Alto Ebro, en particular, y en el interior de la Península Ibérica, en general. En el texto se ofrece una primera evaluación tanto de la secuencia estratigráfica como de los materiales recuperados, esbozando junto con los datos radiocronológicos (inéditos, una primera interpretación de la dinámica ocupacional del lugar. Dada la propia naturaleza del período se revisa el conocimiento disponible en la actualidad sobre el mismo y se reflexiona sobre su caracterización.

  14. Cardiac lipid accumulation associated with diastolic dysfunction in obese mice

    DEFF Research Database (Denmark)

    Christoffersen, Christina; Bollano, Entela; Lindegaard, Marie L S

    2003-01-01

    Obesity may confer cardiac dysfunction due to lipid accumulation in cardiomyocytes. To test this idea, we examined whether obese ob/ob mice display heart lipid accumulation and cardiac dysfunction. Ob/ob mouse hearts had increased expression of genes mediating extracellular generation, transport....../ob mice and 2.5 +/- 0.1 in ob/+ mice (P = 0.0001). In contrast, the indexes of systolic function and heart brain natriuretic peptide mRNA expression were only marginally affected and unaffected, respectively, in ob/ob compared with ob/+ mice. The results suggest that ob/ob mouse hearts have increased...... across the myocyte cell membrane, intracellular transport, mitochondrial uptake, and beta-oxidation of fatty acids compared with ob/+ mice. Accordingly, ob/ob mouse hearts contained more triglyceride (6.8 +/- 0.4 vs. 2.3 +/- 0.4 microg/mg; P hearts. Histological examinations...

  15. Dopady změn nového občanského zákoníku na občanské sdružení v účetní a daňové oblasti

    OpenAIRE

    NOVÁKOVÁ, Lucie

    2017-01-01

    This Bachelor thesis investigates the changes in the New Civil Code and its influence in the area of accounting and taxes within the Civil Association, as that is one of the most common legal forms of non-governmental non-profit organization. The thesis particularly addresses to analyse of accounting and tax changes that have occurred after the law amendment in one specific Civil Association operating in the area of South Bohemia. The New Civil Code cancels the term Civil Association and the ...

  16. Obésité et grossesse : étude de l'influence d'un marqueur de l'obésité sur les mécanismes cellulaires et tissulaires de l'accouchement dans un modèle d'explants myométriaux humains

    OpenAIRE

    Wendremaire, Maeva

    2012-01-01

    Maternal obesity is associated with a wide spectrum of delivery disorders, such as delayed or post-term delivery, that might be explained partly by the increase in plasma leptin levels in obese women, as leptin inhibits in vitro myometrial contractility. Delivery involves uterine apoptosis and remodelling of the extracellular matrix, via the activation of matrix metalloproteinases (MMP). This study was aimed to assess the role of leptin on human myometrium, by studying the interaction of lept...

  17. Nonlinear Geometric and Differential Geometric Guidance of UAVs with Vision Sensing for Reactive Obstacle Avoidance

    Science.gov (United States)

    2010-09-29

    1 1 1 2 2 2ˆ ˆ ˆ ˆ ˆ ˆˆ ˆ ˆ ˆ0 0 0 0 0 0 0 0 0 0 T r ob ob ob ob ob ob tr tr trX r r rθ φ θ φ θ φ= (3.28) 29...ˆ ˆ ˆ ˆˆ ˆ ˆ0 0 0 0 0 0 0 T r ob ob ob tr tr trX r rθ φ θ φ⎡ ⎤= ⎣ ⎦ (3.29) Since obstacles are assumed to be point obstacles, it

  18. Operation UPSHOT-KNOTHOLE, Radiological Safety Operations

    Science.gov (United States)

    1953-06-01

    fi CD tß ED OH (OCfiCfiCfiQQ bb ob ob bb ob ob ob ob ob ob flj <D SÜ (Ü dJ <D(p(U<p(i> >>>>> >>>>> CD CD QQ...PI o in N ~. ^. Ü tD <D T* + + + 93 33 93 c o in o esi r. i- CO CM + + V 33 <u « x...c c C 01 9 O m (U a >> a >• s >> s >• a hä ^>ä b «jgal a^alala^a^ CO CO CO CO CO flj *■" a> 0) QJ

  19. Leptin Production by Encapsulated Adipocytes Increases Brown Fat, Decreases Resistin, and Improves Glucose Intolerance in Obese Mice.

    Directory of Open Access Journals (Sweden)

    David J DiSilvestro

    Full Text Available The neuroendocrine effects of leptin on metabolism hold promise to be translated into a complementary therapy to traditional insulin therapy for diabetes and obesity. However, injections of leptin can provoke inflammation. We tested the effects of leptin, produced in the physiological adipocyte location, on metabolism in mouse models of genetic and dietary obesity. We generated 3T3-L1 adipocytes constitutively secreting leptin and encapsulated them in a poly-L-lysine membrane, which protects the cells from immune rejection. Ob/ob mice (OB were injected with capsules containing no cells (empty, OB[Emp], adipocytes (OB[3T3], or adipocytes overexpressing leptin (OB[Lep] into both visceral fat depots. Leptin was found in the plasma of OB[Lep], but not OB[Emp] and OB[3T3] mice at the end of treatment (72 days. The OB[Lep] and OB[3T3] mice have transiently suppressed appetite and weight loss compared to OB[Emp]. Only OB[Lep] mice have greater brown fat mass, metabolic rate, and reduced resistin plasma levels compared to OB[Emp]. Glucose tolerance was markedly better in OB[Lep] vs. OB[Emp] and OB[3T3] mice as well as in wild type mice with high-fat diet-induced obesity and insulin resistance treated with encapsulated leptin-producing adipocytes. Our proof-of-principle study provides evidence of long-term improvement of glucose tolerance with encapsulated adipocytes producing leptin.

  20. A Characterization of Movement Skills in Obese Children with and without Prader-Willi Syndrome

    Science.gov (United States)

    Lam, Melanie Y.; Rubin, Daniela A.; Duran, Andrea T.; Chavoya, Frank A.; White, Elizabeth; Rose, Debra J.

    2016-01-01

    Purpose: The aim of this study was twofold: (a) to measure and compare motor proficiency in obese children with Prader-Willi syndrome (OB-PWS) to that in obese children without PWS (OB), and (b) to compare motor proficiency in OB-PWS and OB to normative data. Method: Motor proficiency was measured using the Bruininks-Oseretsky Test of Motor…

  1. [Use of the EvalObs® adherence scale in an unselected French population of treated subjects with antihypertensive, hypolipemiants or oral antidiabetics medications: The FLAHS 2017 adherence survey].

    Science.gov (United States)

    Girerd, X; Hanon, O; Vaïsse, B

    2018-05-18

    A Visual Analog Scale (VAS) is useful for diagnosing medication nonadherence and its validity has been evaluated using electronic pillbox as the gold standard. We have developed the EvaLobs ® scale for use on paper or on smartphone and the aim of the study was to administrate the scale among FLAHS 2017 participants treated for an hypertension, a dyslipidemia or diabetes. In subjects treated with antihypertensive medications, participants completed the 6-item Girerd Scale and EvaLobs ® . The French League Against Hypertension Survey (FLAHS) are carried out by self-questionnaire sent by mail to individuals from the French Kantar Health sampling frame (representative panel of the population living in metropolitan France). In 2017, FLAHS was conducted in 4783 subjects aged 35 and over. The EvaLobs ® has a scale from 0 to 15 and the use instruction is "how many days have you taken the drug in the past 15 days". A score>12 indicates a "good compliance". The 6-item Girerd scale was also completed. "Good adherence" was determined for a score of 0 to 2 and "nonadherence" for a score of 3 or more. The agreement between EvaLobs ® and the 6-item Girerd scale was evaluated in treated hypertensives. The survey included 4783 subjects with 1308 treated hypertensives, 942 subjects treated with lipid-lowering drugs and 405 subjects treated with anti-diabetics. EVALOBS ® indicates "Good adherence" in 96% of subjects and the 6 questions questionnaire indicates "good adherence" in 95% of subjects. An excellent agreement is noted in 93.8%. An EvaLobs ® score indicating nonadherence or an absence of response to EvaLobs ® is observed in 3.6% [CI 95, 2.5-4.7] of hypertensives, in 6.0% [CI 95, 3.9-8.1] of diabetics and in 8.2% [CI 95, 6.5-9.9] of dyslipidemic patients. In the population living in France and in unselected patients treated for metabolic disease or hypertension, non-adherence is lowest for antihypertensive medications and highest for statins. EvaLobs ® , which shows good agreement with an adherence questionnaire, is a quick and simple tool for assessing adherence. The smartphone app EvaLobs ® is available for free on Google play and the Apple store. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  2. Zpěv a slovo posvátné - ke studiu obřadní komunikace na počátku 21. století

    Czech Academy of Sciences Publication Activity Database

    Frolcová, Věra

    2009-01-01

    Roč. 57, č. 2 (2009), s. 195-206 ISSN 1335-1303 R&D Projects: GA ČR GA404/05/0182 Institutional research plan: CEZ:AV0Z90580513 Keywords : advent - folk catholic piety * lical spiritual culture * Virgin Mary * Ratíškovice Subject RIV: AC - Archeology, Anthropology, Ethnology

  3. Obrazy občanství v očích studentů, případová studiev rámci střední školy.

    OpenAIRE

    Holcmanová, Kateřina

    2007-01-01

    This master's thesis is concerned with young people attitude towards global citizenship and their identity. It is based on a qualitative research carried out among high schools students (16 - 19 years old).

  4. Odborné poradenství pro sociálně znevýhodněné občany se zaměřením na pracoviště Kontakt

    OpenAIRE

    Štabrňáková, Lucie

    2010-01-01

    The diploma thesis deals with the professional counselling for persons in unfavourable social situation. The seven chapters are concerned with the theoretical study of counselling problems, the eighth chapter addresses particular consultancy centre. The practical part of the thesis provides some information on empirical study carried out at the centre. The origins and the current concepts of professional counselling are briefly described in the first chapter, including a short reference to th...

  5. Rituál, válka, oběť a sňatek na českém jevišti : případ Ífigenie v Aulidě

    Czech Academy of Sciences Publication Activity Database

    Sarkissian, Alena

    2013-01-01

    Roč. 136, 3-4 (2013), s. 443-472 ISSN 0024-4457 Institutional support: RVO:67985955 Keywords : ritual * staging of classical drama * reception of Antiquity * Euripides * Iphigenia at Aulis Subject RIV: AJ - Letters, Mass-media, Audiovision

  6. Česká akademie věd a umění, její kancelář a oběh písemností (1890-1952)

    Czech Academy of Sciences Publication Activity Database

    Šumová, Martina

    2013-01-01

    Roč. 5, č. 1 (2013), s. 1-24 ISSN 1803-9448 Institutional support: RVO:67985921 Keywords : Czech Academy of Sciences and Arts (1890-1952) * Office * Circulation, method of processing and storage of documents Subject RIV: AB - History

  7. Sledování výživové frekvence u dětí obézních a dětí s fyziologickou hmotností

    OpenAIRE

    SMÉKALOVÁ, Dita

    2017-01-01

    Nourishment plays a very important role in a proper children's development. A diet that is rich in a nutrition is necessary for an optimal physical and mental children's development. A number of children with obesity is constantly increasing, where the age of the child is decreasing. Children's obesity is mainly associated with unhealthy eating habits and lack of exercise. The purpose of the "Monitoring nourishment frequency in obese children and children with physiological weight" study is t...

  8. Inhibition of Irvingia gabonensis seed extract (OB131 on adipogenesis as mediated via down regulation of the PPARgamma and Leptin genes and up-regulation of the adiponectin gene

    Directory of Open Access Journals (Sweden)

    Blum Kenneth

    2008-11-01

    Full Text Available Abstract Background Endeavors to manage obesity have been heavily reliant on controlling energy intake and expenditure equilibrium, but have failed to curtail the overweight and obesity epidemic. This dynamic equilibrium is more complex than originally postulated and is influenced by lifestyle, calorie and nutrient intake, reward cravings and satiation, energy metabolism, stress response capabilities, immune metabolism and genetics. Fat metabolism is an important indicator of how efficiently and to what extent these factors are competently integrating. We investigated whether an Irvingia gabonensis seed extract (IGOB131 would provide a more beneficial comprehensive approach influencing multiple mechanisms and specifically PPAR gamma, leptin and adiponectin gene expressions, important in anti-obesity strategies. Methods Using murine 3T3-L1 adipocytes as a model for adipose cell biology research, the effects of IGOB131 were investigated on PPAR gamma, adiponectin, and leptin. These adipocytes were harvested 8 days after the initiation of differentiation and treated with 0 to 250 microM of IGOB131 for 12 and 24 h at 37 degree C in a humidified 5 percent CO2 incubator. The relative expression of PPAR gamma, adiponectin, and leptin in 3T3-L1 adipocytes was quantified densitometrically using the software LabWorks 4.5, and calculated according to the reference bands of beta-actin. Results The IGOB131 significantly inhibited adipogenesis in adipocytes. The effect appears to be mediated through the down-regulated expression of adipogenic transcription factors (PPAR gamma [P less than 0.05] and adipocyte-specific proteins (leptin [P less than 0.05], and by up-regulated expression of adiponectin [P less than 0.05]. Conclusion IGOB131 may play an important multifaceted role in the control of adipogenesis and have further implications in in-vivo anti obesity effects by targeting the PPAR gamma gene, a known contributory factor to obesity in humans.

  9. Vliv oceánských slapů na nízké oběžné dráhy družic Země

    Czech Academy of Sciences Publication Activity Database

    Štěpánek, P.; Bezděk, Aleš

    2013-01-01

    Roč. 59, č. 5 (2013), s. 89-99 ISSN 0016-7096 Grant - others:GA(CZ) GCP209/11/J082 Institutional support: RVO:67985815 Keywords : SPOT-5 * Jason-2 * perturbation forces Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

  10. Parirás con dolor, lo embarazoso de la práctica obs-tétrica: discursos y prácticas que naturalizan la violencia obstétrica en Bogotá

    OpenAIRE

    Vallana Sala, Viviana Valeria

    2016-01-01

    Este texto es un aporte para el análisis de la violencia obstétrica, parte de un ejercicio auto etnográfico de la autora de sus dos embarazos/partos, e involucra el análisis de las historias de embarazo/parto de diez mujeres atendidas en el sistema de salud y las instituciones hospitalarias en Bogotá. Hace un recorrido histórico de las pugnas en la emergencia y hegemonización de la atención biomédica e institucional del embarazo, parto y nacimiento, un análisis sobre los discursos culturales ...

  11. Časopis jako dokument doby. Proměna grafického zpracování obálky časopisu Host do domu (1954-1970)

    Czech Academy of Sciences Publication Activity Database

    Svobodová, Barbora

    2014-01-01

    Roč. 63, 1-2 (2014), s. 66-85 ISSN 1211-7390 Institutional support: RVO:68378068 Keywords : Host do domu (A Guest in the House) * visual culture 50s and 60s * literary magazines * graphic design * magazine cover * 20th century Subject RIV: AJ - Letters, Mass-media, Audiovision

  12. Effect of alkaline earth oxides on the physical and spectroscopic properties of Dy3+- doped Li2O-B2O3 glasses for white emitting material application

    Science.gov (United States)

    Shamshad, L.; Rooh, G.; Kirdsiri, K.; Srisittipokakun, N.; Damdee, B.; Kim, H. J.; Kaewkhao, J.

    2017-02-01

    Li2O-MO-B2O3:0.5Dy2O3 glasses mixed with four different alkaline earth modifier oxides MgO, CaO, SrO and BaO were synthesized by melt quench technique. Their physical properties like density, molar volume and refractive index were measured at room temperature and the effect of alkaline earth modifier oxides were studied. Also, optical absorption and photoluminescence spectra of these glasses have been acquired at room temperature. The Judd-Ofelt theory was effectively used to characterize these spectra and spectral intensities (ƒcal), Judd-Ofelt intensity parameters (Ω2, Ω4 and Ω6) and certain radiative properties have been determined. Radiative life-times (τR), branching ratios (βcal), and emission cross-sections (σp) and optical gain parameters (σp × τR) were calculated from the Judd-Ofelt intensity parameters and the variation in these parameters with the variation of glass matrix are discussed. Yellow/Blue (Y/B) ratio and chromacity color coordinates (x,y) are calculated from the emission spectra which indicates the white light generation from all the investigated samples. The correlated color temperature (CCT) for the studied glasses is found to be 4418 K. The fluorescence decay time (τexp) of the 4F9/2 level of Dy3+ has been measured from the decay profiles and compared with calculated lifetimes (τcal). Among all the studied glass matrices, the glass containing BaO exhibits high value of branching ratio, large emission cross-section and high optical gain parameter for 6F9/2 → 6H13 at 575 nm. The results indicates the suitability of all the studied glasses for laser action and white light generation.

  13. Etika odvrženého a morálka oběti. K pojetí lidství a nelidství u Adorna, Butler a Améryho

    Czech Academy of Sciences Publication Activity Database

    Koubová, Alice

    2014-01-01

    Roč. 69, č. 7 (2014), s. 549-557 ISSN 0046-385X R&D Projects: GA ČR GAP401/10/1164; GA ČR(CZ) GA14-22586S Grant - others:AV ČR(CZ) M300091203 Institutional support: RVO:67985955 Keywords : human * non-human * non-anthropocentric view * Butler * Adorno * Améry * Victim * Offence Subject RIV: AA - Philosophy ; Religion

  14. Kdo se obává kriminality a jak tyto obavy ovlivňují důvěru ve vybrané společenské instituce v České republice?

    Czech Academy of Sciences Publication Activity Database

    Krulichová, Eva

    2016-01-01

    Roč. 52, č. 2 (2016), s. 131-155 ISSN 0038-0288 R&D Projects: GA MŠk LM2015066 Institutional support: RVO:68378025 Keywords : fear of crime * perceived risk of victimisation * police effectiveness Subject RIV: AO - Sociology, Demography Impact factor: 0.143, year: 2016 http://sreview.soc.cas.cz/uploads/ae6d5353c014afaed1937d1b3ef639e26b24c3fb_16-2-02Krulichova18.indd.pdf

  15. Důvěra českých občanů v orgány činné v trestním řízení

    Czech Academy of Sciences Publication Activity Database

    Moravcová, Eva

    2014-01-01

    Roč. 13, č. 6 (2014), s. 143-148 ISSN 1213-5313 R&D Projects: GA MŠk LM2010012 Institutional support: RVO:68378025 Keywords : trust in police and courts * dimensions of trust * ESS R 5 Subject RIV: AG - Legal Sciences

  16. La lingüística hoy: su (reconfiguración a través de los diferentes objetos de estudio Modern linguistics: its (reconfiguration through the different obJects of study

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Mahecha Bermúdez

    2008-12-01

    Full Text Available Este trabajo se sitúa en el ámbito de la historiografía lingüística. El propósito es mostrar las condiciones extra e interdisciplinares que permiten la configuración de objetos de estudio particulares a medida que las comunidades científicas evolucionan. Se verá que la lingüística actual (cognitiva es el resultado de un largo proceso de pulimento del objeto de estudio de la lingüística general, considerada aquella no solo como campo disciplinar, sino también como una actividad "cerebral" humana.This work is located within the field of Linguistic Historiography. The goal is to show the extra and interdisciplinary conditions that allow for the configuration of a particular object of study along with the evolution of the scientific communities. It will be demonstrated that current linguistics (cognitive linguistics is the result of a long process of improvement of the object of study of general linguistics and that cognitive linguistics is not only a discipline but also an activity of the human brain.

  17. Islamismus v současném světě a vliv občanské války v Sýrii na jeho šíření

    OpenAIRE

    Havlíčková, Blanka

    2012-01-01

    This diploma thesis analyzes the ideological basis of islamism and deals with the reasons, why this political ideology is becomimg more and more popular in the Middle East and the West. The thesis also analyzes the phenomenon of globalization, in other words the interconnection between islamists in today's world. The last chapter summarizes the facts about the civil war in Syria, where both - islamists from the Middle East, as well as islamists from the West, are involved. The main objective ...

  18. Investigation of thermal stability and spectroscopic properties in Er3+/Yb3+-codoped TeO2-Li2O-B2O3-GeO2 glasses.

    Science.gov (United States)

    Nie, Qiu-Hua; Gao, Yuan; Xu, Tie-Feng; Shen, Xiang

    2005-06-01

    The new Er3+/Yb3+ co-doped 70TeO2-5Li2O-(25-x)B2O3-xGeO2 (x = 0, 5, 10, 15 fand 20 mol.%) glasses were prepared. The thermal stability, absorption spectra, emission spectra and lifetime of the 4I(13/2) level of Er3+ ions were measured and studied. The FT-IR spectra were carried out in order to investigate the structure of local arrangements in glasses. It is found that the thermal stability, absorption cross-section of Yb3+, emission intensity and lifetime of the 4I(13/2) level of Er3+ increase with increasing GeO2 content in the glass composition, while the fluorescence width at half maximum (FWHM) at 1.5 um of Er3+ is about 70 nm. The obtained data suggest that this system glass can be used as a candidate host material for potential broadband optical amplifiers.

  19. Současný stav nádrží v České republice z hlediska složení rybích obsádek

    Czech Academy of Sciences Publication Activity Database

    Blabolil, Petr; Říha, Milan; Peterka, Jiří; Prchalová, Marie; Vašek, Mojmír; Jůza, Tomáš; Čech, Martin; Draštík, Vladislav; Kratochvíl, Michal; Muška, Milan; Tušer, Michal; Frouzová, Jaroslava; Ricard, Daniel; Šmejkal, Marek; Vejřík, Lukáš; Duras, J.; Matěna, Josef; Borovec, Jakub; Kubečka, Jan

    2014-01-01

    Roč. 64, č. 9 (2014), s. 5-11 ISSN 1211-0760 R&D Projects: GA MŠk(CZ) EE2.3.20.0204 Institutional support: RVO:60077344 Keywords : heavily modified water bodies * species composition * Water Framework Directive Subject RIV: EH - Ecology, Behaviour

  20. Finanční analýza podniku se zaměřením na analýzu oběžného majetku

    OpenAIRE

    Kabelková, Markéta

    2008-01-01

    The thesis is divided into two parts: theoretical and practical. The theoretical part includes financial analysis, analysis of the extramural indicators, ratio indicators and characteristics of floating capital. The practical part includes financial analysis of a firm between the year 2003 and 2007 with the aid of elementary methods of the financial analysis, horizontal and vertical analysis of the financial statements, analysis of the financial ratio indicators and analysis of floating capital.

  1. Ob man an die kleinen Kinder gedacht hat ...?“ Die Verhandlungen über medizinische Hilfe für deutsche Flüchtlinge in Dänemark am Ende des Zweiten Weltkriegs.

    Directory of Open Access Journals (Sweden)

    Michael Schultheiss

    2009-12-01

    Full Text Available At the beginning of May 1945 almost 250.000 refugees from the eastern parts of Germany were in Denmark, having been evacuated into the occupied kingdom. From the arrival of the first refugee in February until the German capitulation in Denmark on May 5, 1945, 6.580 refugees lost their lives. Among them were more than 4.000 children who mostly died of malnutrition and pneumonia.This article examines the reasons behind this death toll and sheds light on the negotiations pertaining to medical help for the refugees between the Danish administration and the German authorities. However, due to egoistical and political considerations both on the German and Danish sides, an agreement was never settled upon.

  2. Transatlantické obchodní a investiční partnerství - nadstandardní ekonomické vztahy mezi oběma břehy Atlantiku ve 21. století?

    OpenAIRE

    Hlavnička, Jindřich

    2016-01-01

    The aim of this thesis it to offer a complex overview of the Transatlantic Trade and Investment Partnership (TTIP). This international agreement is being negotiated between the United States and the European Union. The main goal of this agreement is to create the largest free trade area to date. I wish to claim that the TTIP does not merely concern trade, but there is a clear geopolitical underlining for it too. When the communist world collapsed, the United States became the sole remaining s...

  3. Chief medical clinic manager of a university OB/GYN clinic--an innovative job description as management response for increase of profitability, quality of care, and physicians' freedom of action.

    Science.gov (United States)

    Jacobs, Volker R; Mallmann, Peter

    2010-01-01

    Leadership structures in German clinics are adjusting parallel to DRG (diagnose-related groups)-induced economic reorientation of the health care system. A Chief Medical Clinic Manager (CMCM) is a new job description and an innovative approach to combine medical competence and business economics at the operational level of care. The ideal qualification is a medical specialist in the clinical field with practical experience in patient care and leadership as well as in hospital economics and quality control. A CMCM is placed at a superior level in the clinic, with authorizing competence for the entire physician team. Main tasks are cost transparency within the clinic, organizational development by structured processes, and financial and strategic controlling of all business aspects. A CMCM induces change management and financial adjustment of care to reimbursement with maintaining the standard of care. In cooperation with the director of the clinic, a CMCM develops a vision for clinic development, an investment strategy, and a business plan. The success parameters are positive operative results of the clinic, cost-covering care, increased investment rate, employee satisfaction, and implementation of innovations in research and therapy. A CMCM thereby increases financial and organizational freedom of action at the clinic level in a non-profit public health care system.

  4. Čezmejno sodelovanje na primeru občine Tržič = The crossborder cooperation: a case study of the Tržič municipality

    Directory of Open Access Journals (Sweden)

    Irena Mrak

    1998-01-01

    Full Text Available The Municipality of Tržič borders with the Republic of Austria at the main ridge of the Karavanke mountain. Cooperation with the neighbouring communities Borovlje/Ferlach and Sele/Zell Pfare started in the eighties and it has become more intense after the year 1991. The border that was once separating the inhabitants on both sides of the mountain ridge has become more opened after the slovenian independence but the border control is after Schengen agreement more severe. Remote mountain border areas where access used to be limited were suddenly recognised as a great touristic potential. In the recent years the Municipality of Tržič together with Austrian partners managed to form some joined agriculture and tourism development projects within the PHARE programme (CBC - Crossborder Cooperation and ECOS - Ouverture. The projects deal with the regrowing of buckwheat, preservation of a special sheep breed - jezersko solčavska sheep, activation of the natural monument Dovžan gorge which will be logistically connected to Tscheppa gorge on the austrian side. Within the ECOS Ouverture programme the project of Thematic trails around the Košuta mountain has been initiated in order to reactivate and connect hidden natural and cultural potentials into integrated touristic offer of this part of the Karavanke mountain.

  5. Explicit and Implicit Approach vs. Avoidance Tendencies towards High vs. Low Calorie Food Cues in Patients with Obesity and Active Binge Eating Disorder

    Directory of Open Access Journals (Sweden)

    Georgios Paslakis

    2017-09-01

    Full Text Available Patients with binge eating disorder (BED suffer from regular food binges with loss of control. This may be due to dysfunctional approach vs. avoidance tendencies towards food in BED. We applied an approach-avoidance task (AAT, in which n = 24 patients with obesity and active BED (OB-BED, n = 32 patients with obesity without current BED (OB, and n = 25 healthy controls (CO either approached (“pulled” or avoided (“pushed” high (HC vs. low calorie (LC food pictures. We tested the hypothesis that OB-BED patients would show an approach bias (measured as different response times RT towards HC food compared to the other groups. While there was no main effect for group or direction of movement, a significant main effect for calorie (p < 0.001; RT for HC significantly slower than for LC was found. Repeated measures ANOVA (rm-ANOVA for comparison of OB-BED vs. OB vs. CO revealed a significant three-fold interaction group × direction × calorie (p = 0.02. Against our hypothesis, the OB-BED group showed an avoidance bias for LC. In explicit ratings, OB-BED reported a significantly reduced urge to consume LC food compared to the OB group. Similar to OB-BED, CO also showed an avoidance bias for LC. The implications of our results are discussed and future directions in this field of research are presented.

  6. Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction.

    Science.gov (United States)

    Si, Lislivia Yiang-Nee; Ali, Siti Aishah Mohd; Latip, Jalifah; Fauzi, Norsyahida Mohd; Budin, Siti Balkis; Zainalabidin, Satirah

    2017-12-15

    Obesity increase the risks of hypertension and myocardial infarction (MI) mediated by oxidative stress. This study was undertaken to investigate the actions of roselle aqueous extract (R) on cardiotoxicity in obese (OB) rats and thereon OB rats subjected to MI. Male Sprague-Dawley rats were fed with either normal diet or high-fat diet for 8weeks. Firstly, OB rats were divided into (1) OB and (2) OB+R (100mg/kg, p.o, 28days). Then, OB rats were subjected to MI (ISO, 85mg/kg, s.c, 2days) and divided into three groups: (1) OB+MI, (2) OB+MI+R and (3) OB+MI+enalapril for another 4weeks. Roselle ameliorated OB and OB+MI's cardiac systolic dysfunction and reduced cardiac hypertrophy and fibrosis. The increased oxidative markers and decreased antioxidant enzymes in OB and OB+MI groups were all attenuated by roselle. These observations indicate the protective effect of roselle on cardiac dysfunction in OB and OB+MI rats, which suggest its potential to be developed as a nutraceutical product for obese and obese patients with MI in the future. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice.

    Science.gov (United States)

    Dobrzyn, Pawel; Dobrzyn, Agnieszka; Miyazaki, Makoto; Ntambi, James M

    2010-08-01

    The heart of leptin-deficient ob/ob mice is characterized by pathologic left ventricular hypertrophy along with elevated triglyceride (TG) content, increased stearoyl-CoA desaturase (SCD) activity, and increased myocyte apoptosis. In the present study, using an ob/ob;SCD1(-/-) mouse model, we tested the hypothesis that lack of SCD1 could improve steatosis and left ventricle (LV) function in leptin deficiency. We show that disruption of the SCD1 gene improves cardiac function in ob/ob mice by correcting systolic and diastolic dysfunction without affecting levels of plasma TG and FFA. The improvement is associated with reduced expression of genes involved in FA transport and lipid synthesis in the heart, as well as reduction in cardiac FFA, diacylglycerol, TG, and ceramide levels. The rate of FA beta-oxidation is also significantly lower in the heart of ob/ob;SCD1(-/-) mice compared with ob/ob controls. Moreover, SCD1 deficiency reduces cardiac apoptosis in ob/ob mice due to increased expression of antiapoptotic factor Bcl-2 and inhibition of inducible nitric oxide synthase and caspase-3 activities. Reduction in myocardial lipid accumulation and inhibition of apoptosis appear to be one of the main mechanisms responsible for improved LV function in ob/ob mice caused by SCD1 deficiency.

  8. Accurate ocean bottom seismometer positioning method inspired by multilateration technique

    Science.gov (United States)

    Benazzouz, Omar; Pinheiro, Luis M.; Matias, Luis M. A.; Afilhado, Alexandra; Herold, Daniel; Haines, Seth S.

    2018-01-01

    The positioning of ocean bottom seismometers (OBS) is a key step in the processing flow of OBS data, especially in the case of self popup types of OBS instruments. The use of first arrivals from airgun shots, rather than relying on the acoustic transponders mounted in the OBS, is becoming a trend and generally leads to more accurate positioning due to the statistics from a large number of shots. In this paper, a linearization of the OBS positioning problem via the multilateration technique is discussed. The discussed linear solution solves jointly for the average water layer velocity and the OBS position using only shot locations and first arrival times as input data.

  9. Effects of ovarian steroids and prolactin on the sequential development of nesting behaviour in female budgerigars.

    Science.gov (United States)

    Hutchison, R E

    1975-10-01

    As intact, breeding female budgerigars approach egg-laying, they spend an increasing amount of time in the nestbox and nest hollow. The brood patch area begins to defeather and becomes vascular and the oviduct increases in weight. Precursory albumen forms in the tubular glands of the oviduct. Oestradiol (OB) treatment in combination with prolactin (OB+PL) induced ovariectomized budgerigars to display nesting behaviour which did not differ from that shown by intact females in the 3 days immediately preceding egg-laying. In contrast, OB induced only the initial phase of the nesting sequence and the effects of OB in combination with progesterone (OB+PR) were intermediate between treatments with OB alone and OB+PL. Incubation of artificial eggs occurred only in the OB+PL group and the latency to display of the incubation posture was shorter in the OB+PL group than in the OB+PR group. No incubation posture was displayed by the OB-treated group. Oviduct development was not influenced by prolactin, but progesterone induced precocious development of tubular glands in the magnum region of the oviduct. Treatment with OB+PR induced uniform development of precursor albumen in the tubular glands. Development of the brood patch occurred with both OB+PL and OB+PR treatment. However, OB+PR resulted in defeathering which was advanced in relation to vascularity when compared with intact breeding females, whereas defeathering and vascularity of the OB+PL group did not differ from that of intact females at egg-laying. These results indicate that prolactin in combination with oestradiol was more effective than progesterone not only in inducing the later phases of nesting behaviour but also in initiating incubation behaviour and defeathering of the brood patch area.

  10. Occupation and risk of primary fallopian tube carcinoma in Nordic countries

    DEFF Research Database (Denmark)

    Riska, A; Martinsen, J I; Kjaerheim, K

    2012-01-01

    .11-2.29, Obs = 32), nurses (1.49, 1.14-1.92, Obs = 60), shop workers (1.25, 1.07-1.46, Obs = 159) and clerical workers (1.20, 1.07-1.35, Obs = 271) and these sustained over times and different Nordic countries. There was a nonsignificant increased risk for PFTC among welders, printers, painters and chemical...

  11. Chronic rejection of a lung transplant is characterized by a profile of specific autoantibodies

    DEFF Research Database (Denmark)

    Hagedorn, Peter; Burton, Christopher M.; Carlsen, Jørn

    2010-01-01

    Obliterative bronchiolitis (OB) continues to be the major limitation to long-term survival after lung transplantation. The specific aetiology and pathogenesis of OB are not well understood. To explore the role of autoreactivity in OB, we spotted 751 different self molecules onto glass slides, and...

  12. Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression

    International Nuclear Information System (INIS)

    Inami, Yoshihiro; Yamashina, Shunhei; Izumi, Kousuke; Ueno, Takashi; Tanida, Isei; Ikejima, Kenichi; Watanabe, Sumio

    2011-01-01

    Highlights: → Acidification of autophagosome was blunted in steatotic hepatocytes. → Hepatic steatosis did not disturb fusion of isolated autophagosome and lysosome. → Proteinase activity of cathepsin B and L in autolysosomes was inhibited by steatosis. → Hepatic expression of cathepsin B and L was suppressed by steatosis. -- Abstract: Autophagy, one of protein degradation system, contributes to maintain cellular homeostasis and cell defense. Recently, some evidences indicated that autophagy and lipid metabolism are interrelated. Here, we demonstrate that hepatic steatosis impairs autophagic proteolysis. Though accumulation of autophagosome is observed in hepatocytes from ob/ob mice, expression of p62 was augmented in liver from ob/ob mice more than control mice. Moreover, degradation of the long-lived protein leucine was significantly suppressed in hepatocytes isolated from ob/ob mice. More than 80% of autophagosomes were stained by LysoTracker Red (LTR) in hepatocytes from control mice; however, rate of LTR-stained autophagosomes in hepatocytes were suppressed in ob/ob mice. On the other hand, clearance of autolysosomes loaded with LTR was blunted in hepatocytes from ob/ob mice. Although fusion of isolated autophagosome and lysosome was not disturbed, proteinase activity of cathepsin B and L in autolysosomes and cathepsin B and L expression of liver were suppressed in ob/ob mice. These results indicate that lipid accumulation blunts autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression.

  13. Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression

    Energy Technology Data Exchange (ETDEWEB)

    Inami, Yoshihiro [Department of Gastroenterology, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421 (Japan); Yamashina, Shunhei, E-mail: syamashi@juntendo.ac.jp [Department of Gastroenterology, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421 (Japan); Izumi, Kousuke [Department of Gastroenterology, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421 (Japan); Ueno, Takashi [Department of Biochemistry, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421 (Japan); Tanida, Isei [Department of Biochemistry and Cell Biology, Laboratory of Biomembranes, National Institute of Infectious Disease, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640 (Japan); Ikejima, Kenichi; Watanabe, Sumio [Department of Gastroenterology, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421 (Japan)

    2011-09-09

    Highlights: {yields} Acidification of autophagosome was blunted in steatotic hepatocytes. {yields} Hepatic steatosis did not disturb fusion of isolated autophagosome and lysosome. {yields} Proteinase activity of cathepsin B and L in autolysosomes was inhibited by steatosis. {yields} Hepatic expression of cathepsin B and L was suppressed by steatosis. -- Abstract: Autophagy, one of protein degradation system, contributes to maintain cellular homeostasis and cell defense. Recently, some evidences indicated that autophagy and lipid metabolism are interrelated. Here, we demonstrate that hepatic steatosis impairs autophagic proteolysis. Though accumulation of autophagosome is observed in hepatocytes from ob/ob mice, expression of p62 was augmented in liver from ob/ob mice more than control mice. Moreover, degradation of the long-lived protein leucine was significantly suppressed in hepatocytes isolated from ob/ob mice. More than 80% of autophagosomes were stained by LysoTracker Red (LTR) in hepatocytes from control mice; however, rate of LTR-stained autophagosomes in hepatocytes were suppressed in ob/ob mice. On the other hand, clearance of autolysosomes loaded with LTR was blunted in hepatocytes from ob/ob mice. Although fusion of isolated autophagosome and lysosome was not disturbed, proteinase activity of cathepsin B and L in autolysosomes and cathepsin B and L expression of liver were suppressed in ob/ob mice. These results indicate that lipid accumulation blunts autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression.

  14. TORO: ninety-six-week virologic and immunologic response and safety evaluation of enfuvirtide with an optimized background of antiretrovirals

    NARCIS (Netherlands)

    Reynes, Jacques; Arastéh, Keikawus; Clotet, Bonaventura; Cohen, Calvin; Cooper, David A.; Delfraissy, Jean-François; Eron, Joseph J.; Henry, Keith; Katlama, Christine; Kuritzkes, Daniel R.; Lalezari, Jacob P.; Lange, Joep; Lazzarin, Adriano; Montaner, Julio S. G.; Nelson, Mark; O' Hearn, Mary; Stellbrink, Hans-Jürgen; Trottier, Benoit; Walmsley, Sharon L.; Buss, Neil E.; DeMasi, Ralph; Chung, Jain; Donatacci, Lucille; Guimaraes, Denise; Rowell, Lucy; Valentine, Adeline; Wilkinson, Martin; Salgo, Miklos P.

    2007-01-01

    The additional 48-week optional treatment extension of the T-20 versus Optimized Regimen Only (TORO) studies evaluated long-term safety and efficacy of enfuvirtide (ENF) through week 96 in patients receiving ENF plus optimized background (OB) and patients switching to ENF plus OB from OB alone.

  15. Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice.

    Science.gov (United States)

    Jürgens, Hella S; Schürmann, Annette; Kluge, Reinhart; Ortmann, Sylvia; Klaus, Susanne; Joost, Hans-Georg; Tschöp, Matthias H

    2006-04-13

    Among polygenic mouse models of obesity, the New Zealand obese (NZO) mouse exhibits the most severe phenotype, with fat depots exceeding 40% of total body weight at the age of 6 mo. Here we dissected the components of energy balance including feeding behavior, locomotor activity, energy expenditure, and thermogenesis compared with the related lean New Zealand black (NZB) and obese B6.V-Lep(ob)/J (ob/ob) strains (11% and 65% fat at 23 wk, respectively). NZO mice exhibited a significant hyperphagia that, when food intake was expressed per metabolic body mass, was less pronounced than that of the ob/ob strain. Compared with NZB, NZO mice exhibited increased meal frequency, meal duration, and meal size. Body temperature as determined by telemetry with implanted sensors was reduced in NZO mice, but again to a lesser extent than in the ob/ob strain. In striking contrast to ob/ob mice, NZO mice were able to maintain a constant body temperature during a 20-h cold exposure, thus exhibiting a functioning cold-induced thermogenesis. No significant differences in spontaneous home cage activity were observed among NZO, NZB, and ob/ob strains. When mice had access to voluntary running wheels, however, running activity was significantly lower in NZO than NZB mice and even lower in ob/ob mice. These data indicate that obesity in NZO mice, just as in humans, is due to a combination of hyperphagia, reduced energy expenditure, and insufficient physical activity. Because NZO mice differ strikingly from the ob/ob strain in their resistance to cold stress, we suggest that the molecular defects causing hyperphagia in NZO mice are located distal from leptin and its receptor.

  16. Optimization of the Static Human Osteoblast/Osteoclast Co-culture System

    Directory of Open Access Journals (Sweden)

    James Jam Jolly

    2018-03-01

    Full Text Available Osteoblasts (OBs and osteoclasts (OCs are 2 major groups of bone cells. Their cell-to-cell interactions are important to ensure the continuity of the bone-remodeling process. Therefore, the present study was carried out to optimize an OB/OC co-culture system utilizing the human OB cell line hFOB 1.19 and OCs extracted from peripheral blood mononuclear cells (PBMNCs. It was a 2-step procedure, involving the optimization of the OB culture and the co-culture of the OBs with PBMNCs at an optimum ratio. Firstly, pre-OBs were cultured to 90% confluency and the time required for differentiation was determined. OB differentiation was determined using the van Gieson staining to detect the presence of collagen and Alizarin Red for calcium. Secondly, OBs and OCs were co-cultured at the ratios of 1 OC: 1 OB, 1 OC: 4 OBs, 2 OCs: 1 OB, and 1 OC: 2 OBs. Tartrate-resistant acid phosphatase (TRAP staining was used to detect the differentiation of the OCs. The results showed that collagen was present on day 1, whereas calcium was detected as early as day 3. Based on the result of TRAP staining, 1 OC: 2 OBs was taken as the most appropriate ratio. No macrophage colony-stimulating factor and receptor activator of the nuclear factor-κB ligand were added because they were provided by the OBs. In conclusion, these optimization processes are vital as they ensure the exact time point and ratio of the OB/OC co-culture in order to produce a reliable and reproducible co-culture system.

  17. [Development of the Human Olfactory Bulbs in the Prenatal Ontogenesis: an Immunochistochemical Study with Markers of Presynaptic Terminals (anti-SNAP-25, -Synapsin-I, -Synaptophysin)].

    Science.gov (United States)

    Kharlamova, A S; Barabanov, V M; Saveliev, S V

    2015-01-01

    We provide the data of the olfactory bulbs (OB) development in the human fetuses on the stages from 8 week to birth. Immunochistochemical markers of presynaptic terminals (anti-SNAP-25, -synapsin-I, -synaptophysin) were used to evaluate the maturation of the OB. Differentiation of the OB layers begins from periphery, which implicitly evidences that growth of the olfactory nerves fibers induses not only anatomical differentiation of the OB, but also differentiation of its functional layers. The sites of the developing glomerulus are revealed using the immunochistochemical prosedure on the stage before distinct glomerulus can be identified with common histological procedure. OB conductive system demonstrates immunoreactivity with the antibodies to the presynaptic proteins on the all stages from 10-11 weeks of fetus development. Four stages of the OB development are described. All functional layers of the OB are mature at the 22-weeks stage. Further differentiation of the OB neuroblasts, including lamina formation of the internal granular leyer, glomerular layer development, OB growth continue after 20-22 weeks stage until 38-40 weeks of the fetus develoment. Patterns of the immunoreactivity with antibodies to SNAP-25, synapsin-I and synaptophysin are completely appropriate to those of adult's OB on the 38-40 weeks of the prenatal development. Complete maturity of the human OB is achived at 38-40 weeks of the prenatal development.

  18. Surface Observation Climatic Summaries (SOCS) For Mather AFB, California

    Science.gov (United States)

    1992-02-01

    1100 SPEND (RTS) CE14 GEIS GE25 OBS GE14 GEl8 GE25 OBS GE14 GEl8 GE25 OBS GE14 GEl8 GE25 OBS CATEGORY A 1.7 .5 .1 930 1.6 .6 .1 930 1.6 .4 930 3.4 1.0...ITS) GE14 0E18 GE25 ORS GE14 GEIS GE25 OS GE14 GEl8 GE25 OBS GE14 GE18 GE25 OBS CATEGORY A 5.7 2.4 930 5.2 1.3 .2 930 1.7 .5 .2 930 1.5 .5 .1 930...TIME (LST) 0600 - 2000 ALL HOURS SPEED K75 GE14 GEl8 GE25 OBS GE14 GEl8 UE25 OS CAT Y A 3.5 1.1 .1 4650 2.8 .9

  19. Impaired Coronary and Renal Vascular Function in Spontaneously Type 2 Diabetic Leptin-Deficient Mice.

    Directory of Open Access Journals (Sweden)

    Helena U Westergren

    Full Text Available Type 2 diabetes is associated with macro- and microvascular complications in man. Microvascular dysfunction affects both cardiac and renal function and is now recognized as a main driver of cardiovascular mortality and morbidity. However, progression of microvascular dysfunction in experimental models is often obscured by macrovascular pathology and consequently demanding to study. The obese type 2 diabetic leptin-deficient (ob/ob mouse lacks macrovascular complications, i.e. occlusive atherosclerotic disease, and may therefore be a potential model for microvascular dysfunction. The present study aimed to test the hypothesis that these mice with an insulin resistant phenotype might display microvascular dysfunction in both coronary and renal vascular beds.In this study we used non-invasive Doppler ultrasound imaging to characterize microvascular dysfunction during the progression of diabetes in ob/ob mice. Impaired coronary flow velocity reserve was observed in the ob/ob mice at 16 and 21 weeks of age compared to lean controls. In addition, renal resistivity index as well as pulsatility index was higher in the ob/ob mice at 21 weeks compared to lean controls. Moreover, plasma L-arginine was lower in ob/ob mice, while asymmetric dimethylarginine was unaltered. Furthermore, a decrease in renal vascular density was observed in the ob/ob mice.In parallel to previously described metabolic disturbances, the leptin-deficient ob/ob mice also display cardiac and renal microvascular dysfunction. This model may therefore be suitable for translational, mechanistic and interventional studies to improve the understanding of microvascular complications in type 2 diabetes.

  20. Comparison of onboard low-field magnetic resonance imaging versus onboard computed tomography for anatomy visualization in radiotherapy.

    Science.gov (United States)

    Noel, Camille E; Parikh, Parag J; Spencer, Christopher R; Green, Olga L; Hu, Yanle; Mutic, Sasa; Olsen, Jeffrey R

    2015-01-01

    Onboard magnetic resonance imaging (OB-MRI) for daily localization and adaptive radiotherapy has been under development by several groups. However, no clinical studies have evaluated whether OB-MRI improves visualization of the target and organs at risk (OARs) compared to standard onboard computed tomography (OB-CT). This study compared visualization of patient anatomy on images acquired on the MRI-(60)Co ViewRay system to those acquired with OB-CT. Fourteen patients enrolled on a protocol approved by the Institutional Review Board (IRB) and undergoing image-guided radiotherapy for cancer in the thorax (n = 2), pelvis (n = 6), abdomen (n = 3) or head and neck (n = 3) were imaged with OB-MRI and OB-CT. For each of the 14 patients, the OB-MRI and OB-CT datasets were displayed side-by-side and independently reviewed by three radiation oncologists. Each physician was asked to evaluate which dataset offered better visualization of the target and OARs. A quantitative contouring study was performed on two abdominal patients to assess if OB-MRI could offer improved inter-observer segmentation agreement for adaptive planning. In total 221 OARs and 10 targets were compared for visualization on OB-MRI and OB-CT by each of the three physicians. The majority of physicians (two or more) evaluated visualization on MRI as better for 71% of structures, worse for 10% of structures, and equivalent for 14% of structures. 5% of structures were not visible on either. Physicians agreed unanimously for 74% and in majority for > 99% of structures. Targets were better visualized on MRI in 4/10 cases, and never on OB-CT. Low-field MR provides better anatomic visualization of many radiotherapy targets and most OARs as compared to OB-CT. Further studies with OB-MRI should be pursued.