WorldWideScience

Sample records for nuclear interaction lengths

  1. Proline primed helix length as a modulator of the nuclear receptor-coactivator interaction

    NARCIS (Netherlands)

    Fuchs, S.; Nguyen, H.D.; Phan, T.T.T.; Burton, M.F.; Nieto, L.; Vries-van Leeuwen, I.J. de; Schmidt, A.; Goodarzifard, M.; Agten, S.M.; Rose, R.; Ottmann, C.; Milroy, L.G.; Brunsveld, L.

    2013-01-01

    Nuclear receptor binding to coactivator proteins is an obligate first step in the regulation of gene transcription. Nuclear receptors preferentially bind to an LXXLL peptide motif which is highly conserved throughout the 300 or so natural coactivator proteins. This knowledge has shaped current

  2. Measurement of Pion and Proton Response and Longitudinal Shower Profiles up to 20 Nuclear Interaction Lengths with the ATLAS Tile Calorimeter

    CERN Document Server

    Adragna, P; Anderson, K; Antonaki, A; Arabidze, A; Batkova, L; Batusov, V; Beck, H P; Bergeaas Kuutmann, E; Biscarat, C; Blanchot, G; Bogush, A; Bohm, C; Boldea, V; Bosman, M; Bromberg, C; Budagov, J; Burckhart-Chromek, D; Caprini, M; Caloba, L; Calvet, D; Carli, T; Carvalho, J; Cascella, M; Castelo, J; Castillo, M V; Cavalli-Sforza, M; Cavasinni, V; Cerqueira, A S; Clement, C; Cobal, M; Cogswell, F; Constantinescu, S; Costanzo, D; Corso-Radu, A; Cuenca, C; Damazio, D O; Davidek, T; De, K; Del Prete, T; Di Girolamo, B; Dita, S; Djobava, T; Dobson, M; Dotti, A; Downing, R; Efthymiopoulos, I; Eriksson, D; Errede, D; Errede, S; Farbin, A; Fassouliotis, D; Febbraro, R; Fenyuk, A; Ferdi, C; Ferrer, A; Flaminio, V; Francis, D; Fullana, E; Gadomski, S; Gameiro, S; Garde, V; Gellerstedt, K; Giakoumopoulou, V; Gildemeister, O; Gilewsky, V; Giokaris, N; Gollub, N; Gomes, A; Gonzalez, V; Gorini, B; Grenier, P; Gris, P; Gruwe, M; Guarino, V; Guicheney, C; Gupta, A; Haeberli, C; Hakobyan, H; Haney, M; Hellman, S; Henriques, A; Higon, E; Holmgren, S; Hurwitz, M; Huston, J; Iglesias, C; Isaev, A; Jen-La Plante, I; Jon-And, K; Joos, M; Junk, T; Karyukhin, A; Kazarov, A; Khandanyan, H; Khramov, J; Khubua, J; Kolos, S; Korolkov, I; Krivkova, P; Kulchitsky, Y; Kurochkin, Yu; Kuzhir, P; LeCompte, T; Lefevre, R; Lehmann, G; Leitner, R; Lembesi, M; Lesser, J; Li, J; Liablin, M; Lokajicek, M; Lomakin, Y; Lupi, A; Maidanchik, C; Maio, A; Makouski, M; Maliukov, S; Manousakis, A; Mapelli, L; Marques, C; Marroquim, F; Martin, F; Mazzoni, E; Merritt, F; Miagkov, A; Miller, R; Minashvili, I; Miralles, L; Montarou, G; Mosidze, M; Myagkov, A; Nemecek, S; Nessi, M; Nodulman, L; Nordkvist, B; Norniella, O; Novakova, J; Onofre, A; Oreglia, M; Pallin, D; Pantea, D; Petersen, J; Pilcher, J; Pina, J; Pinhao, J; Podlyski, F; Portell Bueso, X; Poveda, J; Pribyl, L; Price, L E; Proudfoot, J; Ramstedt, M; Richards, R; Roda, C; Romanov, V; Rosnet, P; Roy, P; Ruiz, A; Rumiantsev, V; Russakovich, N; Salto, O; Salvachua, B; Sanchis, E; Sanders, H; Santoni, C; Saraiva, J G; Sarri, F; Satsunkevitch, I; Says, L P; Schlager, G; Schlereth, J; Seixas, J M; Sellden, B; Shalanda, N; Shevtsov, P; Shochet, M; Silva, J; Da Silva, P; Simaitis, V; Simonyan, M; Sissakian, A; Sjolin, J; Solans, C; Solodkov, A; Soloviev, I; Solovyanov, O; Sosebee, M; Spano, F; Stanek, R; Starchenko, E; Starovoitov, P; Stavina, P; Suk, M; Sykora, I; Tang, F; Tas, P; Teuscher, R; Tokar, S; Topilin, N; Torres, J; Tremblet, L; Tsiareshka, P; Tylmad, M; Underwood, D; Unel, G; Usai, G; Valero, A; Valkar, S; Valls, J A; Vartapetian, A; Vazeille, F; Vichou, I; Vinogradov, V; Vivarelli, I; Volpi, M; White, A; Zaitsev, A; Zenine, A; Zenis, T

    2010-01-01

    The response of pions and protons in the energy range of 20 to 180 GeV produced at CERN's SPS H8 test beam line in the ATLAS iron-scintillator Tile hadron calorimeter has been measured. The test-beam configuration allowed to measure the longitudinal shower development for pions and protons up to 20 nuclear interaction lengths. It is found that pions penetrate deeper in the calorimeter than protons. However, protons induce showers that are wider laterally to the direction of the impinging particle. Including the measured total energy response, the pion to proton energy ratio and the resolution, all observations are consistent with a higher electromagnetic energy fraction in pion induced showers. The data are compared with GEANT4 simulations using several hadronic physics lists. The measured longitudinal shower profiles are described by an analytical shower parameterization within an accuracy of 5-10%. The amount of energy leaking out behind the calorimeter is determined and parameterised as a function of the b...

  3. Measurement of pion and proton response and longitudinal shower profiles up to 20 nuclear interaction lengths with the ATLAS Tile calorimeter

    Energy Technology Data Exchange (ETDEWEB)

    Adragna, P [Pisa University and INFN, Pisa (Italy); Alexa, C [National Institute for Physics and Nuclear Engineering, Bucharest (Romania); Anderson, K [University of Chicago, Chicago, IL (United States); Antonaki, A; Arabidze, A [University of Athens, Athens (Greece); Batkova, L [Comenius University, Bratislava (Slovakia); Batusov, V [JINR, Dubna (Russian Federation); Beck, H P [Laboratory for High Energy Physics, University of Bern (Switzerland); Bergeaas Kuutmann, E [Stockholm University, Stockholm (Sweden); Biscarat, C [LPC Clermont-Ferrand, Universite Blaise Pascal, Clermont-Ferrand (France); Blanchot, G [CERN, Geneva (Switzerland); Bogush, A [Institute of Physics, National Academy of Sciences, Minsk (Belarus); Bohm, C [Stockholm University, Stockholm (Sweden); Boldea, V [National Institute for Physics and Nuclear Engineering, Bucharest (Romania); Bosman, M [Institut de Fisica d' Altes Energies, Universitat Autonoma de Barcelona, Barcelona (Spain); Bromberg, C [Michigan State University, East Lansing, MI (United States); Budagov, J [JINR, Dubna (Russian Federation); Burckhart-Chromek, D [CERN, Geneva (Switzerland); Caprini, M [National Institute for Physics and Nuclear Engineering, Bucharest (Romania); Caloba, L [COPPE/EE/UFRJ, Rio de Janeiro (Brazil)

    2010-04-01

    The response of pions and protons in the energy range of 20-180 GeV, produced at CERN's SPS H8 test-beam line in the ATLAS iron-scintillator Tile hadron calorimeter, has been measured. The test-beam configuration allowed the measurement of the longitudinal shower development for pions and protons up to 20 nuclear interaction lengths. It was found that pions penetrate deeper in the calorimeter than protons. However, protons induce showers that are wider laterally to the direction of the impinging particle. Including the measured total energy response, the pion-to-proton energy ratio and the resolution, all observations are consistent with a higher electromagnetic energy fraction in pion-induced showers. The data are compared with GEANT4 simulations using several hadronic physics lists. The measured longitudinal shower profiles are described by an analytical shower parametrization within an accuracy of 5-10%. The amount of energy leaking out behind the calorimeter is determined and parametrized as a function of the beam energy and the calorimeter depth. This allows for a leakage correction of test-beam results in the standard projective geometry.

  4. Measurement of pion and proton response and longitudinal shower profiles up to 20 nuclear interaction lengths with the ATLAS Tile calorimeter

    International Nuclear Information System (INIS)

    Adragna, P.; Alexa, C.; Anderson, K.; Antonaki, A.; Arabidze, A.; Batkova, L.; Batusov, V.; Beck, H.P.; Bergeaas Kuutmann, E.; Biscarat, C.; Blanchot, G.; Bogush, A.; Bohm, C.; Boldea, V.; Bosman, M.; Bromberg, C.; Budagov, J.; Burckhart-Chromek, D.; Caprini, M.; Caloba, L.

    2010-01-01

    The response of pions and protons in the energy range of 20-180 GeV, produced at CERN's SPS H8 test-beam line in the ATLAS iron-scintillator Tile hadron calorimeter, has been measured. The test-beam configuration allowed the measurement of the longitudinal shower development for pions and protons up to 20 nuclear interaction lengths. It was found that pions penetrate deeper in the calorimeter than protons. However, protons induce showers that are wider laterally to the direction of the impinging particle. Including the measured total energy response, the pion-to-proton energy ratio and the resolution, all observations are consistent with a higher electromagnetic energy fraction in pion-induced showers. The data are compared with GEANT4 simulations using several hadronic physics lists. The measured longitudinal shower profiles are described by an analytical shower parametrization within an accuracy of 5-10%. The amount of energy leaking out behind the calorimeter is determined and parametrized as a function of the beam energy and the calorimeter depth. This allows for a leakage correction of test-beam results in the standard projective geometry.

  5. Nuclear reactor with scrammable part length rod

    International Nuclear Information System (INIS)

    Bevilacqua, F.

    1979-01-01

    A new part length rod is provided. It may be used to control xenon induced power oscillations but to contribute to shutdown reactivity when a rapid shutdown of the reactor is required. The part length rod consists of a control rod with three regions. The lower control region is a longer weaker active portion separated from an upper stronger shorter poison section by an intermediate section which is a relative non-absorber of neutrons. The combination of the longer weaker control section with the upper high worth poison section permits the part length rod of this to be scrammed into the core when a reactor shutdown is required but also permits the control rod to be used as a tool to control power distribution in both the axial and radial directions during normal operation

  6. Keeping nuclear hazards at arm's length

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    As national and international regulations are tightened, the permitted radiation dose limits for nuclear workers are being lowered. But sharing the same dose among more people is raising nuclear industry costs. At the same time tasks such as refurbishment and decommissioning are multiplying as the nuclear industry matures. As a result of these trends, work in the nuclear power sector is increasingly having to be done under remote control. European and American progress in the technology was reported recently at a two-day international conference held in London and is reported here. In France 'Frastar' carries out tours of inspection inside reactor buildings under remote control and 'Suzy' is a finger walker robot carrying an arm which is a 3-actuator manipulator. Anglo-American advances are reported; robots with manipulator, cameras, audio signalling and the ability to climb stairs and ramps. A European Community research programme called Teleman was started in 1989 to develop advanced teleoperators for the nuclear industry. The projects underway in this programme are listed. (UK)

  7. Experimental Aspects of Nuclear Interaction

    Energy Technology Data Exchange (ETDEWEB)

    Slaus, I. [Institute ' ' Rudjer Boskovic' ' , Zagreb, Yugoslavia (Croatia)

    1970-07-15

    1. Introduction; 2. Basic features of nuclear interaction; 3. How accurate is our present knowledge of phase parameters? 4. Experimental problems in N-N scattering studies; 5. N-N potential models; 6. Some open problems in nuclear interaction studies. (author)

  8. Progress in Long Scale Length Laser-Plasma Interactions

    International Nuclear Information System (INIS)

    Glenzer, S H; Arnold, P; Bardsley, G; Berger, R L; Bonanno, G; Borger, T; Bower, D E; Bowers, M; Bryant, R; Buckman, S.; Burkhart, S C; Campbell, K; Chrisp, M P; Cohen, B I; Constantin, G; Cooper, F; Cox, J; Dewald, E; Divol, L; Dixit, S; Duncan, J; Eder, D; Edwards, J; Erbert, G; Felker, B; Fornes, J; Frieders, G; Froula, D H; Gardner, S D; Gates, C; Gonzalez, M; Grace, S; Gregori, G; Greenwood, A; Griffith, R; Hall, T; Hammel, B A; Haynam, C; Heestand, G; Henesian, M; Hermes, G; Hinkel, D; Holder, J; Holdner, F; Holtmeier, G; Hsing, W; Huber, S; James, T; Johnson, S; Jones, O S; Kalantar, D; Kamperschroer, J H; Kauffman, R; Kelleher, T; Knight, J; Kirkwood, R K; Kruer, W L; Labiak, W; Landen, O L; Langdon, A B; Langer, S; Latray, D; Lee, A; Lee, F D; Lund, D; MacGowan, B; Marshall, S; McBride, J; McCarville, T; McGrew, L; Mackinnon, A J; Mahavandi, S; Manes, K; Marshall, C; Mertens, E; Meezan, N; Miller, G; Montelongo, S; Moody, J D; Moses, E; Munro, D; Murray, J; Neumann, J; Newton, M; Ng, E; Niemann, C; Nikitin, A; Opsahl, P; Padilla, E; Parham, T; Parrish, G; Petty, C; Polk, M; Powell, C; Reinbachs, I; Rekow, V; Rinnert, R; Riordan, B; Rhodes, M.

    2003-01-01

    The first experiments on the National Ignition Facility (NIF) have employed the first four beams to measure propagation and laser backscattering losses in large ignition-size plasmas. Gas-filled targets between 2 mm and 7 mm length have been heated from one side by overlapping the focal spots of the four beams from one quad operated at 351 nm (3ω) with a total intensity of 2 x 10 15 W cm -2 . The targets were filled with 1 atm of CO 2 producing of up to 7 mm long homogeneously heated plasmas with densities of n e = 6 x 10 20 cm -3 and temperatures of T e = 2 keV. The high energy in a NIF quad of beams of 16kJ, illuminating the target from one direction, creates unique conditions for the study of laser plasma interactions at scale lengths not previously accessible. The propagation through the large-scale plasma was measured with a gated x-ray imager that was filtered for 3.5 keV x rays. These data indicate that the beams interact with the full length of this ignition-scale plasma during the last ∼1 ns of the experiment. During that time, the full aperture measurements of the stimulated Brillouin scattering and stimulated Raman scattering show scattering into the four focusing lenses of 6% for the smallest length (∼2 mm). increasing to 12% for ∼7 mm. These results demonstrate the NIF experimental capabilities and further provide a benchmark for three-dimensional modeling of the laser-plasma interactions at ignition-size scale lengths

  9. Quasiparticle interaction in nuclear matter

    International Nuclear Information System (INIS)

    Poggioli, R.S.; Jackson, A.D.

    1975-07-01

    A microscopic calculation of the quasiparticle interaction in nuclear matter is detailed. In order to take especial care of the contributions from the low momentum states, a model space is introduced. Excluded from the model space, the high momentum states are absorbed into the model interaction. Brueckner theory suggests the choice of a truncated G-matrix as a good approximation for this model interaction. A simple perturbative approach is attempted within the model space. The calculated quasiparticle interaction is consistent with experimental results. (11 tables, 14 figures)

  10. Search for a particle with a long interaction length

    International Nuclear Information System (INIS)

    Barrowes, S.C.; Huggett, R.W.; Jones, W.V.; Levit, L.B.; Porter, L.G.

    1975-01-01

    A search has been carried out for a long-lived particle having an interaction length lambdasub(m) = 300 to 2,000 cm -2 in air. Such a particle, called the mandela, has been proposed by the Leeds group to explain an anomalous energy spectrum of particles observed near sea level with a shallow spectrometer. Data taken at mountain altitude with a deep spectrometer has been examined for compatibility with the existence of the mandela. Although the data tend to favor the mandela hypothesis the results are not conclusive and appear to be explainable by conventional means. (orig.) [de

  11. Driving force for hydrophobic interaction at different length scales.

    Science.gov (United States)

    Zangi, Ronen

    2011-03-17

    We study by molecular dynamics simulations the driving force for the hydrophobic interaction between graphene sheets of different sizes down to the atomic scale. Similar to the prediction by Lum, Chandler, and Weeks for hard-sphere solvation [J. Phys. Chem. B 1999, 103, 4570-4577], we find the driving force to be length-scale dependent, despite the fact that our model systems do not exhibit dewetting. For small hydrophobic solutes, the association is purely entropic, while enthalpy favors dissociation. The latter is demonstrated to arise from the enhancement of hydrogen bonding between the water molecules around small hydrophobes. On the other hand, the attraction between large graphene sheets is dominated by enthalpy which mainly originates from direct solute-solute interactions. The crossover length is found to be inside the range of 0.3-1.5 nm(2) of the surface area of the hydrophobe that is eliminated in the association process. In the large-scale regime, different thermodynamic properties are scalable with this change of surface area. In particular, upon dimerization, a total and a water-induced stabilization of approximately 65 and 12 kJ/mol/nm(2) are obtained, respectively, and on average around one hydrogen bond is gained per 1 nm(2) of graphene sheet association. Furthermore, the potential of mean force between the sheets is also scalable except for interplate distances smaller than 0.64 nm which corresponds to the region around the barrier for removing the last layer of water. It turns out that, as the surface area increases, the relative height of the barrier for association decreases and the range of attraction increases. It is also shown that, around small hydrophobic solutes, the lifetime of the hydrogen bonds is longer than in the bulk, while around large hydrophobes it is the same. Nevertheless, the rearrangement of the hydrogen-bond network for both length-scale regimes is slower than in bulk water. © 2011 American Chemical Society

  12. Experimental evidence of independence of nuclear de-channeling length on the particle charge sign

    Energy Technology Data Exchange (ETDEWEB)

    Bagli, E.; Guidi, V.; Mazzolari, A.; Bandiera, L.; Germogli, G.; Sytov, A.I. [Universita di Ferrara, Dipartimento di Fisica e Scienze della Terra (Italy); INFN Sezione di Ferrara (Italy); De Salvador, D. [Universita di Padova, Dipartimento di Fisica e Astronomia, Padua (Italy); INFN Laboratori Nazionali di Legnaro (Italy); Berra, A.; Prest, M. [Universita dell' Insubria, Como (Italy); INFN Sezione di Milano Bicocca, Milan (Italy); Vallazza, E. [INFN Sezione di Trieste (Italy)

    2017-02-15

    Under coherent interactions, particles undergo correlated collisions with the crystal lattice and their motion result in confinement in the fields of atomic planes, i.e. particle channeling. Other than coherently interacting with the lattice, particles also suffer incoherent interactions with individual nuclei and may leave their bounded motion, i.e., they de-channel. The latter is the main limiting factor for applications of coherent interactions in crystal-assisted particle steering. We experimentally investigated the nature of de-channeling of 120 GeV/c e{sup -} and e{sup +} in a bent silicon crystal at H4-SPS external line at CERN. We found that while channeling efficiency differs significantly for e{sup -} (2 ± 2%) and e{sup +} (54 ± 2%), their nuclear de-channeling length is comparable, (0.6 ± 0.1) mm for e{sup -} and (0.7 ± 0.3) mm for e{sup +}. The experimental proof of the equality of the nuclear de-channeling length for positrons and electrons is interpreted in terms of similar dynamics undergone by the channeled particles in the field of nuclei irrespective of their charge. (orig.)

  13. Emotions and family interactions in childhood: Associations with leukocyte telomere length emotions, family interactions, and telomere length.

    Science.gov (United States)

    Robles, Theodore F; Carroll, Judith E; Bai, Sunhye; Reynolds, Bridget M; Esquivel, Stephanie; Repetti, Rena L

    2016-01-01

    Conceptualizations of links between stress and cellular aging in childhood suggest that accumulating stress predicts shorter leukocyte telomere length (LTL). At the same time, several models suggest that emotional reactivity to stressors may play a key role in predicting cellular aging. Using intensive repeated measures, we tested whether exposure or emotional "reactivity" to conflict and warmth in the family were related to LTL. Children (N=39; 30 target children and 9 siblings) between 8 and 13 years of age completed daily diary questionnaires for 56 consecutive days assessing daily warmth and conflict in the marital and the parent-child dyad, and daily positive and negative mood. To assess exposure to conflict and warmth, diary scale scores were averaged over the 56 days. Mood "reactivity" was operationalized by using multilevel modeling to generate estimates of the slope of warmth or conflict scores (marital and parent-child, separately) predicting same-day mood for each individual child. After diary collection, a blood sample was collected to determine LTL. Among children aged 8-13 years, a stronger association between negative mood and marital conflict, suggesting greater negative mood reactivity to marital conflict, was related to shorter LTL (B=-1.51, pfamily and marital conflict and warmth, and positive and negative mood over a two-month period. To our knowledge, these findings, although cross-sectional, represent the first evidence showing that link between children's affective responses and daily family interactions may have implications for telomere length. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Coulomb corrections to nuclear scattering lengths and effective ranges for weakly bound systems

    International Nuclear Information System (INIS)

    Mur, V.D.; Popov, V.S.; Sergeev, A.V.

    1996-01-01

    A procedure is considered for extracting the purely nuclear scattering length as and effective range rs (which correspond to a strong-interaction potential Vs with disregarded Coulomb interaction) from the experimentally determined nuclear quantities acs and rcs, which are modified by Coulomb interaction. The Coulomb renormalization of as and rs is especially strong if the system under study involves a level with energy close to zero (on the nuclear scale). This applies to formulas that determine the Coulomb renormalization of the low-energy parameters of s scattering (l=0). Detailed numerical calculations are performed for coefficients appearing in the equations that determine Coulomb corrections for various models of the potential Vs(r). This makes it possible to draw qualitative conclusions that the dependence of Coulomb corrections on the form of the strong-interaction potential and, in particular, on its small-distance behavior. A considerable enhancement of Coulomb corrections to the effective range rs is found for potentials with a barrier

  15. Nuclear beta decay and the weak interaction

    International Nuclear Information System (INIS)

    Kean, D.C.

    1975-11-01

    Short notes are presented on various aspects of nuclear beta decay and weak interactions including: super-allowed transitions, parity violation, interaction strengths, coupling constants, and the current-current formalism of weak interaction. (R.L.)

  16. Nuclear interactions and hadronic matter

    International Nuclear Information System (INIS)

    Petrovici, Mihai; Pop, Amalia; Stoicea, Gabriel; Berceanu, Ionela; Moisa, Dorin; Petris, Mariana; Simion, Victor; Aiftimiei, Cristina; Cruceru, Ilie; Ciobanu, Mircea; Catanescu, Vasile; Caragheorgheopol; Gheorghe

    2002-01-01

    The new generation of heavy ion accelerators and complex experimental devices, developed in the last two decades, give access to new information concerning the dynamics of nuclear collisions and allow to obtain and study in the laboratory the nuclear matter under extreme conditions of density and temperature. Of special interest is the intermediate energy region where the reactions are dominated by the competition between the mean field and nucleon-nucleon interaction. Fundamental aspects of nuclear reaction studies are probed at different instants of a nuclear collision. One can learn about the transport properties of nuclear matter in pure nucleonic regime and understand the modification of the nucleon-nucleon cross section due to various in-medium effects: density effects, effective mass, quantum effects, three-body interactions. With increasing energy, fast particle emission associated with direct nucleon-nucleon collisions in the first steps of the reaction come into play too. At higher energy, flow measurements are crucial tests of the influence of medium effects by probing the elastic part of the nucleon-nucleon collisions. On the other side, at higher incident energies, the characteristics of the nuclear equation of state (EoS) can be studied if local thermal and chemical equilibrium turns out to be established. Understanding of the properties of the nuclear matter in extreme conditions is a fundamental goal. The EoS is also an essential ingredient in the description of the massive stars leading to supernova explosion and neutron star formation. Experimental studies of such aspects needs experimental devices of high complexity which can detect and identify event by event all products coming out from heavy ion interactions at intermediate, relativistic and ultra-relativistic energies, having as complete as possible information on their mass, charge, velocity vector. CHIMERA and FOPI are such devices for intermediate and relativistic energy, respectively. Our

  17. Hyperon interactions in nuclear matter

    Energy Technology Data Exchange (ETDEWEB)

    Dhar, Madhumita; Lenske, Horst [Institut fuer Theoretische Physik, Universitaet Giessen (Germany)

    2014-07-01

    Baryon-baryon interactions within the SU(3)-octet are investigated in free space and nuclear matter. A meson exchange model is used for determining the interaction. The Bethe-Salpeter equations are solved in a 3-D reduction scheme. In-medium effects have been incorporated by including a two particle Pauli projection operator in the scattering equation. The coupling of the various channels of total strangeness S=-1,-2 and conserved total charge is studied in detail. Calculations and the corresponding results are compared for using the isospin and the particle basis. Matrix elements are compared in detail, in particular discussing mixing effects of different hyperon channels. Special attention is paid to the physical thresholds. The density dependence of interaction is clearly seen in the variation of the in-medium low-energy parameters. The approach is compared to descriptions derived from chiral-EFT and other meson-exchange models e.g. the Nijmegen and the Juelich model.

  18. Nuclear reaction inputs based on effective interactions

    Energy Technology Data Exchange (ETDEWEB)

    Hilaire, S.; Peru, S.; Dubray, N.; Dupuis, M.; Bauge, E. [CEA, DAM, DIF, Arpajon (France); Goriely, S. [Universite Libre de Bruxelles, Institut d' Astronomie et d' Astrophysique, CP-226, Brussels (Belgium)

    2016-11-15

    Extensive nuclear structure studies have been performed for decades using effective interactions as sole input. They have shown a remarkable ability to describe rather accurately many types of nuclear properties. In the early 2000 s, a major effort has been engaged to produce nuclear reaction input data out of the Gogny interaction, in order to challenge its quality also with respect to nuclear reaction observables. The status of this project, well advanced today thanks to the use of modern computers as well as modern nuclear reaction codes, is reviewed and future developments are discussed. (orig.)

  19. Nuclear physics and fundamental interactions

    International Nuclear Information System (INIS)

    Krmpotic, K.

    1980-01-01

    In this work, it is discussed strong, weak and electromagnetic interactions. By means of experiments and theoretical interpretation of these interactions it was possible to interpret important properties, which will be discussed here. (A.C.A.S.) [pt

  20. Symmetric nuclear matter with Skyrme interaction

    International Nuclear Information System (INIS)

    Manisa, K.; Bicer, A.; Atav, U.

    2010-01-01

    The equation of state (EOS) and some properties of symmetric nuclear matter, such as the saturation density, saturation energy and incompressibility, are obtained by using Skyrme's density-dependent effective nucleon-nucleon interaction.

  1. Realistic effective interactions for nuclear systems

    International Nuclear Information System (INIS)

    Hjort-Jensen, M.; Osnes, E.; Kuo, T.T.S.

    1994-09-01

    A review of perturbative many-body descriptions of several nuclear systems is presented. Symmetric and asymmetric nuclear matter and finite nuclei with few valence particles are examples of systems considered. The many-body description starts with the most recent meson-exchange potential models for the nucleon-nucleon interaction, an interaction which in turn is used in perturbative schemes to evaluate the effective interaction for finite nuclei and infinite nuclear matter. A unified perturbative approach based on time-dependent perturbation theory is elaborated. For finite nuclei new results are presented for the effective interaction and the energy spectra in the mass areas of oxygen, calcium and tin. 166 refs., 83 refs., 21 tabs

  2. DNA Length Modulates the Affinity of Fragments of Genomic DNA for the Nuclear Matrix In Vitro.

    Science.gov (United States)

    García-Vilchis, David; Aranda-Anzaldo, Armando

    2017-12-01

    Classical observations have shown that during the interphase the chromosomal DNA of metazoans is organized in supercoiled loops attached to a compartment known as the nuclear matrix (NM). Fragments of chromosomal DNA able to bind the isolated NM in vitro are known as matrix associated/attachment/addressed regions or MARs. No specific consensus sequence or motif has been found that may constitute a universal, defining feature of MARs. On the other hand, high-salt resistant DNA-NM interactions in situ define true DNA loop anchorage regions or LARs, that might correspond to a subset of the potential MARs but are not necessarily identical to MARs characterized in vitro, since there are several examples of MARs able to bind the NM in vitro but which are not actually bound to the NM in situ. In the present work we assayed the capacity of two LARs, as well as of shorter fragments within such LARs, for binding to the NM in vitro. Paradoxically the isolated (≈2 kb) LARs cannot bind to the NM in vitro while their shorter (≈300 pb) sub-fragments and other non-related but equally short DNA fragments, bind to the NM in a high-salt resistant fashion. Our results suggest that the ability of a given DNA fragment for binding to the NM in vitro primarily depends on the length of the fragment, suggesting that binding to the NM is modulated by the local topology of the DNA fragment in suspension that it is known to depend on the DNA length. J. Cell. Biochem. 118: 4487-4497, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  3. Hadronic and nuclear interactions in QCD

    International Nuclear Information System (INIS)

    1982-01-01

    Despite the evidence that QCD - or something close to it - gives a correct description of the structure of hadrons and their interactions, it seems paradoxical that the theory has thus far had very little impact in nuclear physics. One reason for this is that the application of QCD to distances larger than 1 fm involves coherent, non-perturbative dynamics which is beyond present calculational techniques. For example, in QCD the nuclear force can evidently be ascribed to quark interchange and gluon exchange processes. These, however, are as complicated to analyze from a fundamental point of view as is the analogous covalent bond in molecular physics. Since a detailed description of quark-quark interactions and the structure of hadronic wavefunctions is not yet well-understood in QCD, it is evident that a quantitative first-principle description of the nuclear force will require a great deal of theoretical effort. Another reason for the limited impact of QCD in nuclear physics has been the conventional assumption that nuclear interactions can for the most part be analyzed in terms of an effective meson-nucleon field theory or potential model in isolation from the details of short distance quark and gluon structure of hadrons. These lectures, argue that this view is untenable: in fact, there is no correspondence principle which yields traditional nuclear physics as a rigorous large-distance or non-relativistic limit of QCD dynamics. On the other hand, the distinctions between standard nuclear physics dynamics and QCD at nuclear dimensions are extremely interesting and illuminating for both particle and nuclear physics

  4. Hyperfine interactions measured by nuclear orientation technique

    International Nuclear Information System (INIS)

    Brenier, R.

    1982-01-01

    This report concerns the use of hyperfine interaction to magnetism measurements and to the determination of the nuclear structure of Terbium isotopes by the low temperature nuclear orientation technique. In the first part we show that the rhodium atom does not support any localized moment in the chromium matrix. The hyperfine magnetic field at the rhodium nuclear site follows the Overhauser distribution, and the external applied magnetic field supports a negative Knight shift of 16%. In the second part we consider the structure of neutron deficient Terbium isotopes. We introduce a coherent way of evaluation and elaborate a new nuclear thermometer. The magnetic moments allows to strike on the studied states configuration. The analysis of our results shows a decrease of the nuclear deformation for the lighter isotopes [fr

  5. QCD Structure of Nuclear Interactions

    Energy Technology Data Exchange (ETDEWEB)

    Granados, Carlos [Florida Intl Univ., Miami, FL (United States)

    2011-05-25

    This dissertation investigated selected processes involving baryons and nuclei in hard scattering reactions. Through these processes, this work explored the constituent structure of baryons and the mechanisms through which the interactions between these constituents ultimately control the selected reactions. First, hard nucleon-nucleon elastic scattering was studied considering the quark exchange (QE) between the nucleons to be the dominant mechanism of interaction in the constituent picture. It was found that an angular asymmetry exhibited by proton-neutron (pn) elastic scattering data is explained within this framework if a quark-diquark picture dominates the nucleon's structure instead of a more traditional SU(6) model. The latter yields an asymmetry around 90 deg center of mass scattering with a sign opposite to what is experimentally observed. The second process is the hard breakup by a photon of a nucleon-nucleon system in light nuclei. Proton-proton (pp) and pn breakup in 3He, and double Δ-isobars production in deuteron breakup were analyzed in the hard rescattering model (HRM), which in conjunction with the QE mechanism provides a QCD description of the reaction. Cross sections for both channels in 3He photodisintegration were computed without the need of a fitting parameter. The results presented here for pp breakup show excellent agreement with recent experimental data. In double Δ-isobars production in deuteron breakup, HRM angular distributions for the two double Δ channels were compared to the pn channel and to each other. An important prediction from this study is that the Δ++ Δ- channel consistently dominates Δ+Δ0, which is in contrast with models that unlike the HRM consider a double Δ system in the initial state of the interaction. For such models both channels should have the same strength.

  6. Direct interaction in nuclear reactions: a theory

    International Nuclear Information System (INIS)

    Dominicis, C.T. de

    1959-01-01

    General treatment of the foundations of direct interaction in nuclear reactions; representation of the instantaneous elastic scattering amplitude by the scattering amplitude due to a complex potential; expansion of the instantaneous inelastic scattering amplitude and discussion of the 1. Bohr approximation (distorted waves) contribution to individual and collective states of excitation. (author) [fr

  7. Nuclear interactive evaluations on distributed processors

    International Nuclear Information System (INIS)

    Dix, G.E.; Congdon, S.P.

    1988-01-01

    BWR [boiling water reactor] nuclear design is a complicated process, involving trade-offs among a variety of conflicting objectives. Complex computer calculations and usually required for each design iteration. GE Nuclear Energy has implemented a system where the evaluations are performed interactively on a large number of small microcomputers. This approach minimizes the time it takes to carry out design iterations even through the processor speeds are low compared with modern super computers. All of the desktop microcomputers are linked to a common data base via an ethernet communications system so that design data can be shared and data quality can be maintained

  8. Nuclear cycle length economics strategy using stochastic and deterministic Monte Carlo computation models

    International Nuclear Information System (INIS)

    Wook Ahn, T.

    2014-01-01

    Nuclear power plants (NPP) have historically been a low cost base-load electricity source because of their high fuel density and operational reliability. In the United States, NPPs typically run 18- to 24-month cycles to limit outage times and maximize capacity factor. recently, however, increased volatility in energy and fuel prices, lower natural gas prices, higher material costs, and new sources are challenging the nuclear industry. This warrants a study in developing a more robust cycle length and fuel burnup strategy to make NPPs more competitive. (Author)

  9. Nuclear cycle length economics strategy using stochastic and deterministic Monte Carlo computation models

    Energy Technology Data Exchange (ETDEWEB)

    Wook Ahn, T.

    2014-07-01

    Nuclear power plants (NPP) have historically been a low cost base-load electricity source because of their high fuel density and operational reliability. In the United States, NPPs typically run 18- to 24-month cycles to limit outage times and maximize capacity factor. recently, however, increased volatility in energy and fuel prices, lower natural gas prices, higher material costs, and new sources are challenging the nuclear industry. This warrants a study in developing a more robust cycle length and fuel burnup strategy to make NPPs more competitive. (Author)

  10. Constant scattering length fits to low energy K-p interactions

    International Nuclear Information System (INIS)

    Conboy, J.E.

    1985-10-01

    The paper concerns the data on low energy K - p interactions analysed using the constant scattering length (C.S.L.) approximation. The scattering lengths are found to differ significantly from those required to fit data from previous K -1 p experiments, and these differences are discussed. The data indicate an Tspin=1 P- wave interaction, from the production angle distributions of the K-bar 0 n, Σ +- π -+ and Λπ 0 channels. However the authors have been unable to fit both the P-wave and K 0 sub(L)p data with the simple C.S.L. model. (U.K.)

  11. Length of Maternity Leave and Quality of Mother-Infant Interactions.

    Science.gov (United States)

    Clark, Roseanne; And Others

    1997-01-01

    Assessed association between length of maternity leave and quality of mother-infant interaction. Found a direct association between shorter leave and more negative affect and behavior; mothers with more depressive symptoms or who perceived their infant as having a difficult temperament, and with shorter leaves expressed less positive affect,…

  12. Nuclear structure and neutrino-nucleus interaction

    International Nuclear Information System (INIS)

    Krmpotic, Francisco

    2011-01-01

    Recent years have witnessed an intense experimental and theoretical activity oriented towards a better comprehension of neutrino nucleus interaction. While the main motivation for this task is the demand coming from oscillation experiments in their search for a precise determination of neutrino properties, the relevance of neutrino interaction with matter is more wide-ranging. It is imperative for astrophysics, hadronic and nuclear physics, and physics beyond the standard model. The experimental information on neutrino induced reactions is rapidly growing, and the corresponding theoretical description is a challenging proposition, since the energy scales of interest span a vast region, going from few MeV for solar neutrinos, to tens of MeV for the interpretation of experiments with the muon and pion decay at rest and the detection of neutrinos coming from the core collapse of supernova, and to hundreds of MeV or few GeV for the detection of atmospheric neutrinos, and for the neutrino oscillation program of the MiniBooNE experiment. The presence of neutrinos, being chargeless particles, can only be inferred by detecting the secondary particles created in colliding and interacting with the matter. Nuclei are often used as neutrino detectors, and in particular 12 C which is a component of many scintillator detectors. Thus, the interpretation of neutrino data heavily relies on detailed and quantitative knowledge of the features of the neutrino-nucleus interaction. The nuclear structure methods used in the evaluation of the neutrino-nucleus cross section are reviewed. Detailed comparison between the experimental and theoretical results establishes benchmarks needed for verification and/or parameter adjustment of the nuclear models. Having a reliable tool for such calculation is of great importance in a variety of applications, such as the description of the r-process nucleosynthesis. (author)

  13. Proton-neutron interaction and nuclear structure

    International Nuclear Information System (INIS)

    Casten, R.F.

    1986-01-01

    The pervasive role of the proton-neutron interaction in nuclear structure is discussed. Particular emphasis is given to its influence on the onset of collectivity and deformation, on intruder states, and on the evolution of subshell structure. The N/sub p/N/sub n/ scheme is outlined and some applications of it to collective model calculations and to nuclei far off stability are described. The concept of N/sub p/N/sub n/ multiplets is introduced. 32 refs., 20 figs

  14. Characterization of relaxation processes in interacting vortex matter through a time-dependent correlation length

    International Nuclear Information System (INIS)

    Pleimling, Michel; Täuber, Uwe C

    2015-01-01

    Vortex lines in type-II superconductors display complicated relaxation processes due to the intricate competition between their mutual repulsive interactions and pinning to attractive point or extended defects. We perform extensive Monte Carlo simulations for an interacting elastic line model with either point-like or columnar pinning centers. From measurements of the space- and time-dependent height-height correlation function for lateral flux line fluctuations, we extract a characteristic correlation length that we use to investigate different non-equilibrium relaxation regimes. The specific time dependence of this correlation length for different disorder configurations displays characteristic features that provide a novel diagnostic tool to distinguish between point-like pinning centers and extended columnar defects. (paper)

  15. Neutrino neutral current interactions in nuclear matter

    International Nuclear Information System (INIS)

    Horowitz, C.J.; Wehrberger, K.

    1991-01-01

    Detailed knowledge of neutrino transport properties in matter is crucial for an understanding of the evolution of supernovae and of neutron star cooling. We investigate screening of neutrino scattering from a dense degenerate gas of electrons, protons and neutrons. We take into account correlations induced by the Coulomb interactions of the electrons and protons, and the strong interactions of the protons and neutrons. Nuclear matter is described by the σω model of quantum hadrodynamics. Results are presented for typical astrophysical scenarios. The differential cross section is strongly reduced at large energy transfer, where electrons dominate, and slightly reduced for small energy transfer, where nucleons dominate. At large densities, the nucleon effective mass is considerably lower than the free mass, and the region dominated by nucleons extends to larger energy transfer than for free nucleons. (orig.)

  16. Determination of nn scattering length from data on nn final state interaction in nd-breakup reaction

    International Nuclear Information System (INIS)

    Konobeevski, E.S.; Mordovskoy, M.V.; Sergeev, V.A.; Potashev, S.I.; Zuev, S.V.

    2006-01-01

    Full text: An experiment is proposed for the high-precision determination of the neutron-neutron scattering length investigating the nn final state interaction in the nd breakup reaction. The singlet pp and nn scattering lengths are very sensitive probes of the NN-interaction, and their difference is a direct measure of charge-symmetry breaking (CSB) of the nuclear force. However CSB is a small effect, and accurate values of the scattering lengths are needed for a theoretical analysis. The proton-proton scattering length is well known from pp-scattering data (a pp = -17.3± 0.4 fm), and its uncertainty is mainly due to a model-dependent procedure of removing Coulomb effects. The neutron-neutron scattering length is determined from the following processes n+d→p+n+n, π - + d → γ +n+n, d+d→ 2 He+n+n by investigating the kinematic region of the nn final-state interaction (FSI) where two neutrons fly with low relative energy. The results obtained by now are characterized by a significant uncertainty in values of a nn ; they are grouped near -16 and -19 fm [1,2], so even the sign of the difference a nn - a pp is uncertain. In this experiment neutron-neutron scattering length is determined by measuring the yield of the nd breakup reaction as a function of the relative energy ε nn =(E 1 +E 2 -2(E 1 E 2 ) 1/2 cosθ)/2 of two neutrons in the FSI region (two neutrons fly in a narrow angular cone) where nn-interaction is strongly revealed. The theory of reactions in 3N system predicts the ε nn dependence of the FSI cross section being sensitive to the value of a nn . The measurements will be made using the neutron channel RADEX at Moscow meson factory of the Institute for Nuclear Research. The momenta and angles of the two emitted neutrons and the energy of the proton will be measured for each breakup event. The measured dependence of the reaction yield on the relative energy of the two neutrons will be compared to results of the Monte Carlo simulation that includes

  17. Optical design for increased interaction length in a high gradient dielectric laser accelerator

    OpenAIRE

    Cesar, D.; Maxson, J.; Musumeci, P.; Shen, X.; England, R. J.; Wootton, K. P.

    2018-01-01

    We present a methodology for designing and measuring pulse front tilt in an ultrafast laser for use in dielectric laser acceleration. Previous research into dielectric laser accelerating modules has focused on measuring high accelerating gradients in novel structures, but has done so only for short electron-laser coupling lengths. Here we demonstrate an optical design to extend the laser-electron interaction to 1mm.

  18. The Nuclear Age: Context for Family Interaction.

    Science.gov (United States)

    Ptacek, Carmen

    1988-01-01

    Suggests that concerns regarding the nuclear threat are prevalent among family members; parents and children feel powerless in response to the nuclear threat; response to the nuclear threat is a family issue; responding to the nuclear threat requires empowering families and changing the social context; and nuclear concerns need to be addressed in…

  19. Aggregation behavior and intermicellar interactions of cationic Gemini surfactants: Effects of alkyl chain, spacer lengths and temperature

    International Nuclear Information System (INIS)

    Hajy Alimohammadi, Marjan; Javadian, Soheila; Gharibi, Hussein; Tehrani-Bagha, Ali reza; Alavijeh, Mohammad Rashidi; Kakaei, Karim

    2012-01-01

    Graphical abstract: Highlights: → Enthalpy-entropy compensation relation was found between and for gemini surfactants. → The intermicellar interaction parameters are influenced with increasing the lengths of the tail and the spacer of gemini surfactants. → Increasing temperature decreases the intermicellar interaction parameters. → The changes in micellar surface charge density, and phase transition between spherical and rod geometries explain the data. - Abstract: The aggregation behavior of the cationic Gemini surfactants C m H 2m+1 N(CH 3 ) 2 (CH 2 ) S (CH 3 ) 2 N C m H 2m+1 ,2Br - with m = 12, 14 and s = 2, 4 were studied by performing surface tension, electrical conductivity, pulsed field gradient nuclear magnetic resonance (PFG-NMR), and cyclic voltammetry (CV) measurements over the temperature range 298 K to 323 K. The critical micelle concentration (CMC), surface excess (Γ max ), mean molecular surface area (A min ), degree of counter ion dissociation (α), and the thermodynamic parameters of micellization were determined from the surface tension and conductance data. An enthalpy-entropy compensation effect was observed and all the plots of enthalpy-entropy compensation exhibit excellent linearity. The micellar self-diffusion coefficients (D m ) and intermicellar interaction parameters (k d ) were obtained from the PFG-NMR and CV measurements. These results are discussed in terms of the intermicellar interactions, the effects of the chain and spacer lengths on the micellar surface charge density, and the phase transition between spherical and rod geometries. The intermicellar interaction parameters were found to decrease slightly with increasing temperature for 14-4-14, which suggests that the micellar surface charge density decreases with increasing temperature. The mean values of the hydrodynamic radius, R h , and the aggregation number, N agg , of the Gemini surfactants'm-4-m micelles were calculated from the micellar self-diffusion coefficient

  20. Nuclear spectroscopy with density dependent effective interactions

    International Nuclear Information System (INIS)

    Krewald, S.

    1976-07-01

    The paper investigates excited nuclear states with density-dependent effective interactions. In the first part of the paper, the structure and the width of the multipole giant resonances discovered in 1972 are derived microscopically. Because of their high excitation energy, these giant resonances are unstable to particle emission and thus often have a considerable decay width. Due to their collective structure, the giant resonances can be described by RPA in good approximation. In this paper, the continuum RPA is applied to the spherical nuclei 16 O, 40 Ca, 90 Zr and 208 Pb. The experimental centroid energy are in very good agreement with the calculations performed in the paper. (orig./WL) [de

  1. Three nucleon interaction and nuclear composition

    International Nuclear Information System (INIS)

    Pandharipande, V.R.

    1983-01-01

    The author discusses results of some of the calculations carried out by J. Carlson, I. Lagaris, J. Lomnitz-Adler, R.A. Smith, R.B. Wiringa and himself to study the three nucleon interaction. The group has attempted to calculate the wavefunctions and binding energies of 3 H, 3 He, 4 He and nuclear matter, with the variational method, from a nonrelativistic Hamiltonian. Only nucleon degrees of freedom are retained in this Hamiltonian; the effects of other degrees of freedom are implicit in the two and three nucleon potentials. The author discusses further the calculations carried out, in collaboration with B. Friman, and R.B. Wiringa, to study the composition of nuclei. Nucleons interact by many processes including exchange of pions with or without excitation to isobar (Δ) states. Thus the nucleus contains pions being exchanged, and some nucleons in the Δ state. The group attempts to calculate the number and momentum distribution of these exchanged pions, and the fraction of time a nucleon in the nucleus is in the Δ state. 21 references, 4 figures

  2. Millimeter length micromachining using a heavy ion nuclear microprobe with standard magnetic scanning

    International Nuclear Information System (INIS)

    Nesprías, F.; Debray, M.E.; Davidson, J.; Kreiner, A.J.

    2013-01-01

    In order to increase the scanning length of our microprobe, we have developed an irradiation procedure suitable for use in any nuclear microprobe, extending at least up to 400% the length of our heavy ion direct writing facility using standard magnetic exploration. Although this method is limited to patterns of a few millimeters in only one direction, it is useful for the manufacture of curved waveguides, optical devices such Mach–Zehnder modulators, directional couplers as well as channels for micro-fluidic applications. As an example, this technique was applied to the fabrication of 3 mm 3D-Mach–Zehnder modulators in lithium niobate with short Y input/output branches and long shaped parallel-capacitor control electrodes. To extend and improve the quality of the machined structures we developed new scanning control software in LabView™ platform. The new code supports an external dose normalization, electrostatic beam blanking and is capable of scanning figures at 16 bit resolution using a National Instruments™ PCI-6731 High-Speed I/O card. A deep and vertical micromachining process using swift 35 Cl ions 70 MeV bombarding energy and direct write patterning was performed on LiNbO 3 , a material which exhibits a strong natural anisotropy to conventional etching. The micromachined structures show the feasibility of this method for manufacturing micro-fluidic channels as well

  3. Millimeter length micromachining using a heavy ion nuclear microprobe with standard magnetic scanning

    Energy Technology Data Exchange (ETDEWEB)

    Nesprías, F. [Gerencia de Investigación y Aplicaciones, Comisión Nacional de Energía Atómica, Av. Gral Paz 1499 (1650), San Martín, Buenos Aires (Argentina); Debray, M.E., E-mail: debray@tandar.cnea.gov.ar [Gerencia de Investigación y Aplicaciones, Comisión Nacional de Energía Atómica, Av. Gral Paz 1499 (1650), San Martín, Buenos Aires (Argentina); Escuela de Ciencia y Tecnología. Universidad Nacional de Gral. San Martín, M. De Irigoyen 3100 (1650), San Martín, Buenos Aires (Argentina); Davidson, J. [Gerencia de Investigación y Aplicaciones, Comisión Nacional de Energía Atómica, Av. Gral Paz 1499 (1650), San Martín, Buenos Aires (Argentina); CONICET, Avda. Rivadavia 1917 (C1033AAJ), Ciudad Autónoma de Buenos Aires (Argentina); Kreiner, A.J. [Gerencia de Investigación y Aplicaciones, Comisión Nacional de Energía Atómica, Av. Gral Paz 1499 (1650), San Martín, Buenos Aires (Argentina); Escuela de Ciencia y Tecnología. Universidad Nacional de Gral. San Martín, M. De Irigoyen 3100 (1650), San Martín, Buenos Aires (Argentina); CONICET, Avda. Rivadavia 1917 (C1033AAJ), Ciudad Autónoma de Buenos Aires (Argentina); and others

    2013-04-01

    In order to increase the scanning length of our microprobe, we have developed an irradiation procedure suitable for use in any nuclear microprobe, extending at least up to 400% the length of our heavy ion direct writing facility using standard magnetic exploration. Although this method is limited to patterns of a few millimeters in only one direction, it is useful for the manufacture of curved waveguides, optical devices such Mach–Zehnder modulators, directional couplers as well as channels for micro-fluidic applications. As an example, this technique was applied to the fabrication of 3 mm 3D-Mach–Zehnder modulators in lithium niobate with short Y input/output branches and long shaped parallel-capacitor control electrodes. To extend and improve the quality of the machined structures we developed new scanning control software in LabView™ platform. The new code supports an external dose normalization, electrostatic beam blanking and is capable of scanning figures at 16 bit resolution using a National Instruments™ PCI-6731 High-Speed I/O card. A deep and vertical micromachining process using swift {sup 35}Cl ions 70 MeV bombarding energy and direct write patterning was performed on LiNbO{sub 3}, a material which exhibits a strong natural anisotropy to conventional etching. The micromachined structures show the feasibility of this method for manufacturing micro-fluidic channels as well.

  4. Spatial interaction models from Irish commuting data: variations in trip length by occupation and gender

    Science.gov (United States)

    O'Kelly, Morton E.; Niedzielski, Michael A.; Gleeson, Justin

    2012-10-01

    Core and peripheral contrasts in journey-to-work trip length can be interpreted as imputing the relative value of origin and destination accessibility (yielding theoretical proxies for rent and wages). Because the main variables are shown to be critically dependent on spatial structure, they may be interpreted as showing the shadow prices due to comparative location. There is also a unifying connection between these results and the existing literature on many dimensions: rent gradients, accessibility, and emissivity. In an empirical example, the advantages of a panoramic view of national commuting statistics are shown, using an Irish data set. Variations in the rates of participation in trip making by location, occupation, and gender are examined. Places that emit more trips than would be expected from their relative location are identified. Further, examining ways in which such emissivity is sensitive to a change in trip length highlights the regions where trips could possibly be adjusted to produce a shorter average trip length or which might be especially sensitive to reduction in employment. A careful reinterpretation of one of the key outputs from a calibrated spatial interaction model is shown to be consistent with the declining rent gradient expected from Alonso's theory of land use.

  5. Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles.

    Science.gov (United States)

    Chen, Hsin-Yi; Wu, Chien-Ting; Tang, Chieh-Ju C; Lin, Yi-Nan; Wang, Won-Jing; Tang, Tang K

    2017-08-15

    Mutations in many centriolar protein-encoding genes cause primary microcephaly. Using super-resolution and electron microscopy, we find that the human microcephaly protein, RTTN, is recruited to the proximal end of the procentriole at early S phase, and is located at the inner luminal walls of centrioles. Further studies demonstrate that RTTN directly interacts with STIL and acts downstream of STIL-mediated centriole assembly. CRISPR/Cas9-mediated RTTN gene knockout in p53-deficient cells induce amplification of primitive procentriole bodies that lack the distal-half centriolar proteins, POC5 and POC1B. Additional analyses show that RTTN serves as an upstream effector of CEP295, which mediates the loading of POC1B and POC5 to the distal-half centrioles. Interestingly, the naturally occurring microcephaly-associated mutant, RTTN (A578P), shows a low affinity for STIL binding and blocks centriole assembly. These findings reveal that RTTN contributes to building full-length centrioles and illuminate the molecular mechanism through which the RTTN (A578P) mutation causes primary microcephaly.Mutations in many centriolar protein-encoding genes cause primary microcephaly. Here the authors show that human microcephaly protein RTTN directly interacts with STIL and acts downstream of STIL-mediated centriole assembly, contributing to building full-length centrioles.

  6. The interacting effects of temperature and food chain length on trophic abundance and ecosystem function.

    Science.gov (United States)

    Beveridge, Oliver S; Humphries, Stuart; Petchey, Owen L

    2010-05-01

    1. While much is known about the independent effects of trophic structure and temperature on density and ecosystem processes, less is known about the interaction(s) between the two. 2. We manipulated the temperature of laboratory-based bacteria-protist communities that contained communities with one, two, or three trophic levels, and recorded species' densities and bacterial decomposition. 3. Temperature, food chain length and their interaction produced significant responses in microbial density and bacterial decomposition. Prey and resource density expressed different patterns of temperature dependency during different phases of population dynamics. The addition of a predator altered the temperature-density relationship of prey, from a unimodal trend to a negative one. Bacterial decomposition was greatest in the presence of consumers at higher temperatures. 4. These results are qualitatively consistent with a recent model of direct and indirect temperature effects on resource-consumer population dynamics. Results highlight and reinforce the importance of indirect effects of temperature mediated through trophic interactions. Understanding and predicting the consequences of environmental change will require that indirect effects, trophic structure, and individual species' tolerances be incorporated into theory and models.

  7. Nuclear science and metallurgy. Advances and interactions

    International Nuclear Information System (INIS)

    Grison, Emmanuel

    1977-01-01

    The history of the production of atomic power by fission since 1953 is reviewed: metallurgy of uranium; the new metals zirconium and beryllium; steels and nuclear structure; nuclear reactor vessels; water corrosion; effects of radiations [fr

  8. Nuclear science and metallurgy. Advances and interactions

    Energy Technology Data Exchange (ETDEWEB)

    Grison, E [CEA Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France)

    1977-01-01

    The history of the production of atomic power by fission since 1953 is reviewed: metallurgy of uranium; the new metals zirconium and beryllium; steels and nuclear structure; nuclear reactor vessels; water corrosion; effects of radiations.

  9. Stabilization of the Electron-Nuclear Spin Orientation in Quantum Dots by the Nuclear Quadrupole Interaction

    Science.gov (United States)

    Dzhioev, R. I.; Korenev, V. L.

    2007-07-01

    The nuclear quadrupole interaction eliminates the restrictions imposed by hyperfine interaction on the spin coherence of an electron and nuclei in a quantum dot. The strain-induced nuclear quadrupole interaction suppresses the nuclear spin flip and makes possible the zero-field dynamic nuclear polarization in self-organized InP/InGaP quantum dots. The direction of the effective nuclear magnetic field is fixed in space, thus quenching the magnetic depolarization of the electron spin in the quantum dot. The quadrupole interaction suppresses the zero-field electron spin decoherence also for the case of nonpolarized nuclei. These results provide a new vision of the role of the nuclear quadrupole interaction in nanostructures: it elongates the spin memory of the electron-nuclear system.

  10. Collisional scattering for binary Coulomb interactions that are cut off at a distance different than the Debye length

    International Nuclear Information System (INIS)

    Correa, J.R.; Chang Yongbin; Ordonez, C.A.

    2005-01-01

    Collisional scattering is considered within a system of charged particles experiencing binary Coulomb interactions when the scale length for the range of each interaction is not isotropic and is not necessarily equal to the Debye length. For example, one or more dimensions of the system could be smaller than the Debye length. The effect is assessed by evaluating integrals over the impact cross section. Cutoffs on both the impact parameter and the Coulomb interaction potential are employed, and no assumption is made regarding the value of the Coulomb logarithm. Two expressions are found that have a dependence on the cutoff lengths, with one of the expressions being associated with the Coulomb logarithm. Collisional scattering within an electrostatic ion trap is considered by way of example

  11. Neutrino interactions, proton production and a nuclear effect

    International Nuclear Information System (INIS)

    Guy, J.; Allport, P.P.; Cooper-Sarkar, A.; Sansum, R.A.; Venus, W.; Berggren, M.; Morrison, D.R.O.; Parker, M.A.; Wachsmuth, H.; Clayton, E.F.; Mobayyen, M.M.; Hulth, P.O.; Katz, U.; Wittek, W.; Marage, P.; Sacton, J.; Matsinos, E.; Simopoulou, E.; Myatt, G.; Neveu, M.; Apeldoorn, G.W. van

    1989-01-01

    Neutrino interactions are classified by the presence or absence of protons with momentum below 600 MeV/c at the interaction vertex. Interactions producing protons have softer x distributions for hydrogen and deuterium targets as well as for neon. In contrast to a recent claim, the effect is therefore not directly related to any nuclear effect in neon. (orig.)

  12. Neutrino interactions, proton production and a nuclear effect

    Science.gov (United States)

    Guy, J.; Allport, P. P.; Berggren, M.; Clayton, E. F.; Cooper-Sarkar, A.; Hulth, P. O.; Jones, G. T.; Katz, U.; Marage, P.; Matsinos, E.; Mobayyen, M. M.; Morrison, D. R. O.; Myatt, G.; Neveu, M.; O'Neale, S.; Parker, M. A.; Sacton, J.; Sansum, R. A.; Simopoulou, E.; van Apeldoorn, G. W.; Varvell, K.; Venus, W.; Wachsmuth, H.; Wittek, W.

    1989-10-01

    Neutrino interactions are classified by the presence or absence of protons with momentum below 600 MeV/c at the interaction vertex. Interactions producing protons have softer x distributions for hydrogen and deuterium targets as well as for neon. In contrast to a recent claim, the effect is therefore not directly related to any nuclear effect in neon.

  13. Consideration on the interaction between society and nuclear technology

    International Nuclear Information System (INIS)

    Shinoda, Yoshihiko

    2007-01-01

    A social conflict over nuclear technology arises from the different interactions between society and nuclear technology. The purpose of this review is to grasp the essential points of this social conflict from a social viewpoint. These essential points can be discerned by interpreting results of polls about nuclear technology and the future of society in general. As a result, attitudes towards nuclear technology can be explained in terms of differences of general views on society such as social order or social progress. The attitudes of people toward nuclear technology were divided into strong agreement, weak agreement, weak objection and strong objection in order to obtain useful information for clarification of social conflict on this issue. Results of polls of people who have weak agreement for nuclear technology reveal their ambivalence about nuclear technology. This raises concern that further implementation of nuclear technology might cause these people to shift their views to objection. (author)

  14. Studies of neutron emission from relativistic nuclear interactions

    CERN Document Server

    Guo, S L; Wang, Y L; Guo, H Y; Sá Ben-Hao; Zheng, Y M; Brandt, R; Vater, P; Wan, J S; Ochs, M; Kulakov, B A; Sosnin, A N; Krivopustov, M I; Butsev, V S; Bradnova, V

    1999-01-01

    Studies were carried out on the yields and spatial distributions of secondary neutrons produced in the relativistic nuclear interactions of 1.5 GeV to 14.4 GeV projectiles p, d and alpha-particles with targets Pb and U/Pb. CR-39 track detectors were used to measure the neutrons. It shows that: (1) Secondary neutrons are produced in the whole length of Pb or U targets having a thickness of 20 cm. The neutron intensities produced by proton bombardments are reduced along the proton beam direction in the targets. The higher the energy of protons, the lower the reduction rate of the neutrons. The reduction rate of neutrons in U target is higher than in Pb target for the same energy of protons. (2) The radial intensities of neutrons decrease as the distance increases from the target central line. (3) The neutron yield in U target by proton bombardments is approx 55% higher than in Pb target. (4) The ratio of neutron yield by 14.4 GeV alpha to 7.3 GeV d bombardment in Pb target is 1.74+-0.20.

  15. Effective interaction: From nuclear reactions to neutron stars

    Indian Academy of Sciences (India)

    pact stars. The nuclear EoS for β-equilibrated neutron star (NS) matter obtained using density-dependent effective nucleon–nucleon interaction satisfies the constraints from the observed flow data from heavy-ion collisions. The energy density of quark matter is lower than that of the nuclear EoS at higher densities implying ...

  16. Weak interaction studies from nuclear beta decay

    International Nuclear Information System (INIS)

    Morita, M.

    1981-01-01

    The studies performed at the theoretical nuclear physics division of the Laboratory of Nuclear Studies, Osaka University, are reported. Electron spin density and internal conversion process, nuclear excitation by electron transition, beta decay, weak charged current, and beta-ray angular distributions in oriented nuclei have been studied. The relative intensity of internal conversion electrons for the case in which the radial wave functions of orbital electrons are different for electron spin up and down was calculated. The calculated value was in good agreement with the experimental one. The nuclear excitation following the transition of orbital electrons was studied. The calculated probability of the nuclear excitation of Os 189 was 1.4 x 10 - 7 in conformity with the experimental value 1.7 x 10 - 7 . The second class current and other problems on beta-decay have been extensively studied, and described elsewhere. Concerning weak charged current, the effects of all induced terms, the time component of main axial vector, all partial waves of leptons, Coulomb correction for the electrons in finite size nuclei, and radiative correction were studied. The beta-ray angular distribution for the 1 + -- 0 + transition in oriented B 12 and N 12 was investigated. In this connection, investigation on the weak magnetism to include all higher order corrections for the evaluation of the spectral shape factors was performed. Other works carried out by the author and his collaborators are also explained. (Kato, T.)

  17. On deep inelastic lepton-nuclear interactions

    International Nuclear Information System (INIS)

    Garsevanishvili, V.R.; Darbaidze, Ya.Z.; Menteshashvili, Z.R.; Ehsakiya, Sh.M.

    1981-01-01

    The problem of building relativistic theory of nuclear reactions by way of involving relativistic methods, developed in the elementary particle theory, becomes rather actual at the time being. The paper presents some results of investigations into deep inelastic lepton-nuclear processes lA → l'(A-1)x, with the spectator nucleus-fragment in the finite state. To describe the reactions lA → l'(A-1)x (where l=an electron, muan, neutrino, antineutrino), the use is made of the self-similarity principle and multiparticle quasipotential formalism in the ''light front'' variables. The expressions are obtained for the differential cross-sections of lepton-nuclear processes and for the structure functions of deep inelastic scattering of neutrinos (antineutrinos) and charged leptons by nuclei

  18. Length dependence of staircase potentiation: interactions with caffeine and dantrolene sodium.

    Science.gov (United States)

    Rassier, D E; MacIntosh, B R

    2000-04-01

    In skeletal muscle, there is a length dependence of staircase potentiation for which the mechanism is unclear. In this study we tested the hypothesis that abolition of this length dependence by caffeine is effected by a mechanism independent of enhanced Ca2+ release. To test this hypothesis we have used caffeine, which abolishes length dependence of potentiation, and dantrolene sodium, which inhibits Ca2+ release. In situ isometric twitch contractions of rat gastrocnemius muscle before and after 20 s of repetitive stimulation at 5 Hz were analyzed at optimal length (Lo), Lo - 10%, and Lo + 10%. Potentiation was observed to be length dependent, with an increase in developed tension (DT) of 78 +/- 12, 51 +/- 5, and 34 +/- 9% (mean +/- SEM), at Lo - 10%, Lo, and Lo + 10%, respectively. Caffeine diminished the length dependence of activation and suppressed the length dependence of staircase potentiation, giving increases in DT of 65+/-13, 53 +/- 11, and 45 +/- 12% for Lo - 10%, Lo, and Lo + 10%, respectively. Dantrolene administered after caffeine did not reverse this effect. Dantrolene alone depressed the potentiation response, but did not affect the length dependence of staircase potentiation, with increases in DT of 58 +/- 17, 26 +/- 8, and 18 +/- 7%, respectively. This study confirms that there is a length dependence of staircase potentiation in mammalian skeletal muscle which is suppressed by caffeine. Since dantrolene did not alter this suppression of the length dependence of potentiation by caffeine, it is apparently not directly modulated by Ca2+ availability in the myoplasm.

  19. The ability to form full-length intron RNA circles is a general property of nuclear group I introns

    DEFF Research Database (Denmark)

    Nielsen, Henrik; Fiskaa, Tonje; Birgisdottir, Asa Birna

    2003-01-01

    at the expense of the host. The circularization pathway has distinct structural requirements that differ from those of splicing and appears to be specifically suppressed in vivo. The ability to form full-length circles is found in all types of nuclear group I introns, including those from the Tetrahymena...... ribosomal DNA. The biological function of the full-length circles is not known, but the fact that the circles contain the entire genetic information of the intron suggests a role in intron mobility....

  20. Neutron-triton scattering lengths for interactions reproducing low-energy trinucleon data

    International Nuclear Information System (INIS)

    Levashev, V.P.

    1981-01-01

    By solving the integral equations for four nucleons the neutron-triton scattering lengths and total cross section are calculated using different S-wave rank-one separable potentials. A number of linear correlations between the neutron-triton scattering lengths and triton binding energy are found. The scattering lengths consistent with low-energy trinucleon data. The results obtained are compared with available experimental data [ru

  1. Information Interaction with IAEA on Nuclear Import and Export

    International Nuclear Information System (INIS)

    Osokina, A.; Snytnikov, A.

    2015-01-01

    This paper considers organizational aspects of nuclear import and export interaction between the Russian Federation and the Agency. Requirements of nuclear import and export in Russia, information submission procedure and forms are determined in RF Government Regulation No 973 from December 15th 2000. Particularly, according to these requirements Russian licenced organizations implementing nuclear import and export submit reports about appointed transfers to State Corporation 'Rosatom'. Regulations of State Corporation 'Rosatom' entrusted gathering and processing of reporting information and interaction with IAEA to FSUE 'SCC of Rosatom'. Regulations of reporting information interaction were developed by SCC and approved by State Corporation 'Rosatom'. Russian organizations send notifications to SCC using regulation electron or paper forms. Regulations determine information security measures in reporting process. Automated nuclear import and export accounting system developed by SCC provides data entering, keeping and processing, enables to choose and submit requested information in different formats. This system is integrated with State Nuclear Material Control and Accounting System. Also submitted information is regularly compared with customs declarations data to improve reliability and consistency of information. Generalized nuclear import and export data is using by Departments of State Corporation 'Rosatom' and transmitting to Federal Environmental, Industrial and Nuclear Supervision Service of Russia in agreed forms. Summary information about international nuclear transfers is sending to IAEA according to INFCIRC/207. Reporting information is coordinating. Messaging with IAEA is realized by email using enciphering program. (author)

  2. A study of topological quantum phase transition and Majorana localization length for the interacting helical liquid system

    International Nuclear Information System (INIS)

    Dey, Dayasindhu; Saha, Sudip Kumar; Deo, P. Singha; Kumar, Manoranjan; Sarkar, Sujit

    2017-01-01

    We study the topological quantum phase transition and also the nature of this transition using the density matrix renormalization group method. We observe the existence of topological quantum phase transition for repulsive interaction, however this phase is more stable for the attractive interaction. The length scale dependent study shows many new and important results and we show explicitly that the major contribution to the excitation comes from the edge of the system when the system is in the topological state. We also show the dependence of Majorana localization length for various values of chemical potential. (author)

  3. The weak interaction in nuclear, particle and astrophysics

    International Nuclear Information System (INIS)

    Grotz, K.; Klapdor, H.V.

    1989-01-01

    This book is an introduction to the concepts of weak interactions and their importance and consequences for nuclear physics, particle physics, neutrino physics, astrophysics and cosmology. After a general introduction to elementary particles and interactions the Fermi theory of weak interactions is described together with its connection with nuclear structure and beta decay including the double beta decay. Then, after a general description of gauge theories the Weinberg-Salam theory of the electroweak interactions is introduced. Thereafter the weak interactions are considered in the framework of grand unification. Then the physics of neutrinos is discussed. Thereafter connections of weak interactions with astrophysics are considered with special regards to the gravitational collapse and the synthesis of heavy elements in the r-process. Finally, the connections of grand unified theories and cosmology are considered. (HSI) With 141 figs., 39 tabs

  4. Landau parameters for finite range density dependent nuclear interactions

    International Nuclear Information System (INIS)

    Farine, M.

    1997-01-01

    The Landau parameters represent the effective particle-hole interaction at Fermi level. Since between the physical observables and the Landau parameters there is a direct relation their derivation from an effective interaction is of great interest. The parameter F 0 determines the incompressibility K of the system. The parameter F 1 determines the effective mass (which controls the level density at the Fermi level). In addition, F 0 ' determines the symmetry energy, G 0 the magnetic susceptibility, and G 0 ' the pion condensation threshold in nuclear matter. This paper is devoted to a general derivation of Landau parameters for an interaction with density dependent finite range terms. Particular carefulness is devoted to the inclusion of rearrangement terms. This report is part of a larger project which aims at defining a new nuclear interaction improving the well-known D1 force of Gogny et al. for describing the average nuclear properties and exotic nuclei and satisfying, in addition, the sum rules

  5. Future prospects in n-nuclear interactions

    International Nuclear Information System (INIS)

    Moss, J.M.

    1982-01-01

    I examine in detail two research areas, polarization observables and antiproton-nucleus reactions, which should have near-term future impact on our understanding of the interaction of medium-energy nucleons in nuclei. More speculative future experiments employing cooled beams, double spectrometer systems, and large Q-valure low momentum-transfer reactions are also discussed

  6. Aqueous solutions/nuclear glasses interactions

    International Nuclear Information System (INIS)

    Delage, F.; Advocat, T.; Vernaz, E.; Crovisier, J.L.

    1991-01-01

    Interactions results of the borosilicate glass used in radioactive wastes confinement and aqueous solutions at various temperature and PH show that for the glass components: - the release rate evolution follows an Arrhenius law, - in acid PH, there is a selective dissolution, - in basic PH, there is a stoechiometric dissolution [fr

  7. The temperature pulse propagation in interacting nuclear slabs

    International Nuclear Information System (INIS)

    Kozlowski, M.; Zurich Univ.

    1989-01-01

    Following the method developed by R.J. Swenson a non-Fourier equation for heat transfer in nuclear matter is obtained. The velocity of heat propagation is calculated and the value υ s = υ F /√3 is obtained. For two interacting nuclear slabs the temperature as a function of time is calculated. For a nucleon mean free path λ ≅ 3 fm the temperature saturation time is calculated and the value ≅ 160 fm/c is obtained. (orig.)

  8. Interactive visual analysis of nuclear data with ZVView

    International Nuclear Information System (INIS)

    Zerkin, Viktor

    2002-01-01

    This paper describes the cross section graphics software package ZVVIEW that was developed for the evaluators to perform efficient interactive visual analysis of experimental and theoretical nuclear data. ZVVIEW is a very powerful and complete package that simplifies the presentation of nuclear cross section data. A CD-ROM version of this computer package is available from the IAEA-NDS on request. (a.n.)

  9. Nuclear medicine and the environment: radiation interactions

    International Nuclear Information System (INIS)

    Schmelter, R.F.

    1986-01-01

    The effect of radiation interactions on the environment may be considered from the perspective of the purely physical phenomena occurring or from the effects the interactions produce in organized biological systems. The physical processes by which radiation interacts with the environment are quite well defined. Although these processes differ depending upon the nature (either electromagnetic or particulate) of the primary radiation, the ultimate result is the production in the medium of high-speed, secondary charged particles. Some of the energy of these particles is absorbed by the medium, while a portion may be lost as bremsstrahlung. The energy that is absorbed produces excitation and ionization, which can be disruptive to biological systems. The effects produced by ionizing radiations at the biochemical, cellular, and organ level are less well defined. Nevertheless, available data indicate that certain generalizations are possible. For example, given the ubiquitous nature of water in tissues, macromolecules, regardless of their structural types, tend to serve as acceptors of the energy and products of water radiolysis. However, a deeper insight into the consequences of irradiation requires an understanding of the interplay of such parameters as the type and energy of the radiation, and the dose and rate of its application. Furthermore, at the cellular level, the type and age of the irradiated cells, the concentration of oxygen in their environment, and their cell-cycle phase are all important factors in determining the consequences of irradiation. 72 references

  10. Lambda-nuclear interactions and hyperon puzzle in neutron stars

    Energy Technology Data Exchange (ETDEWEB)

    Haidenbauer, J. [Forschungszentrum Juelich, Institute for Advanced Simulation, Institut fuer Kernphysik and Juelich Center for Hadron Physics, Juelich (Germany); Universitaet Bonn, Helmholtz Institut fuer Strahlen- und Kernphysik and Bethe Center for Theoretical Physics, Bonn (Germany); Meissner, U.G. [Universitaet Bonn, Helmholtz Institut fuer Strahlen- und Kernphysik and Bethe Center for Theoretical Physics, Bonn (Germany); Forschungszentrum Juelich, Institute for Advanced Simulation, Institut fuer Kernphysik and Juelich Center for Hadron Physics, Juelich (Germany); Kaiser, N.; Weise, W. [Technische Universitaet Muenchen, Physik Department, Garching (Germany)

    2017-06-15

    Brueckner theory is used to investigate the in-medium properties of a Λ-hyperon in nuclear and neutron matter, based on hyperon-nucleon interactions derived within SU(3) chiral effective field theory (EFT). It is shown that the resulting Λ single-particle potential U{sub Λ}(p{sub Λ} = 0, ρ) becomes strongly repulsive for densities ρ of two-to-three times that of normal nuclear matter. Adding a density-dependent effective ΛN-interaction constructed from chiral ΛNN three-body forces increases the repulsion further. Consequences of these findings for neutron stars are discussed. It is argued that for hyperon-nuclear interactions with properties such as those deduced from the SU(3) EFT potentials, the onset for hyperon formation in the core of neutron stars could be shifted to much higher density which, in turn, could pave the way for resolving the so-called hyperon puzzle. (orig.)

  11. Method for operating a nuclear reactor with scrammable part length rod

    International Nuclear Information System (INIS)

    Bevilacqua, F.

    1979-01-01

    A new part length rod is provided which may be used to control xenon induced power oscillations but also to contribute to shutdown reactivity when a rapid shutdown of the reactor is required. The part length rod consists of a control rod with three regions. The lower control region is a longer weaker active portion separated from an upper stronger shorter poison section by an intermediate section which is a relative non-absorber of neutrons. The combination of the longer weaker control section with the upper high worth poison section permits the part length rod to be scrammed into the core. When a reactor shutdown is required but also permits the control rod to be used as a tool to control power distribution in both the axial and radial directions during normal operation

  12. Considerations about soil-structures interaction in nuclear power plants

    International Nuclear Information System (INIS)

    Muzzi, F.

    1977-01-01

    The main features of the soil-structure interaction for nuclear power plant are presented as they resulted from conservations that the author carried out at the Berkeley (California) University, at the California Institute of Technology and at the U.S. Nuclear Regulatory Commission in Washington (Dec 1975). The complete and inertial interaction approaches of analysis are discussed. The complete approach by the use of finite element technique as suggested by the U.S.N.R.C. Standard Review Plan 3.7.1. (June 1975) is finally described. (author)

  13. Nuclear electric quadrupole interactions in liquids entrapped in cavities

    Energy Technology Data Exchange (ETDEWEB)

    Furman, Gregory B., E-mail: gregoryf@bgu.ac.il; Meerovich, Victor M.; Sokolovsky, Vladimir L. [Ben Gurion University of the Negev, Physics Department (Israel)

    2016-12-15

    Liquids entrapped in cavities and containing quadrupole nuclei are considered. The interaction of the quadrupole moment of a nucleus with the electric field gradient is studied. In such a system, molecules are in both rotational and translational Brownian motions which are described by the diffusion equation. Solving this equation, we show that the intra- and intermolecular nuclear quadrupole interactions are averaged to zero in cavities with the size larger than several angstroms.

  14. ORNL capability to conduct post irradiation examination of full-length commercial nuclear fuel rods

    International Nuclear Information System (INIS)

    Spellman, Donald J.

    2007-01-01

    Hot cells at Oak Ridge National Laboratory (ORNL) are nearing completion of a multi-year upgrade program to implement 21. century capabilities to meet the examination demands for higher burnup fuels and the future demands that will come from fuel recycling programs. Fuel reliability and zero tolerance for fuel failure is more than an industry goal. Fuel reliability is becoming a requirement that supports the renaissance of nuclear power generation. Thus, fuel development and management of new forms of waste that will come from programs such as the Global Nuclear Energy Partnership (GNEP) will require extensive use of the flexible, high-quality, technically advanced hot cells at ORNL. ORNL has the capability to perform post irradiation examination (PIE) of irradiated commercial nuclear fuel rods and the management structure to ensure a timely, cost-effective result. ORNL can: 1) Handle the transportation issues, 2) Perform macroscopic fuel rod examinations, 3) Perform microscopic fuel and clad examinations, and 4) Manage legacy material and waste disposal issues from PIE activities. All four of these items will be managed in a way that allows the customer day-to-day access to the results and data. Hot cell examination equipment that is necessary to determine the characteristics and performance of irradiated materials must operate in a hostile environment and is subject to long-term degradation that may result in reliability and quality assurance (QA) issues. ORNL has modernized its hot cell nuclear fuel examination equipment, installing state-of-the-art automated examination equipment and data gathering capabilities. ORNL is planning a major commitment to nuclear fuel examination and development, and future improvements will continue to be made over the next few years. (author)

  15. Searches for exotic interactions in nuclear beta decay

    Energy Technology Data Exchange (ETDEWEB)

    Naviliat-Cuncic, O. [National Superconducting Cyclotron Laboratory and Department of Physics and Astronomy, Michigan State University, 640 S Shaw Lane, East Lansing MI 48824 (United States)

    2016-07-07

    This contribution presents current efforts in the search for exotic interactions in nuclear β decay using a calorimetric technique for the measurement of the β energy spectrum shape. We describe the criteria for the choice of sensitive candidates in Gamow-Teller transitions and present the status of measurements performed in {sup 6}He and {sup 20}F decay.

  16. Pure nuclear reflexes and combined hyperfine interactions in YIG

    Energy Technology Data Exchange (ETDEWEB)

    Winkler, H; Eisberg, R; Alp, E; Rueffer, R; Gerdau, E; Lauer, S; Trautwein, A X; Grodzicki, M; Vera, A

    1983-01-01

    Moessbauer spectra of oriented YIG single crystals were taken and the numerical analysis using the transmission integral yielded a consistent set of hyperfine interaction parameters. They are in good agreement with theoretical values obtained by MO-calculations which included clusters up to 62 ions. Finally pure nuclear reflexes are predicted for single crystals and two theoretical spectra are given.

  17. Static and Covariant Meson-Exchange Interactions in Nuclear Matter

    International Nuclear Information System (INIS)

    Carlson, B.V.; Hirata, D.

    2011-01-01

    The Dirac version of static meson exchange interactions provides a good description of low-energy NN scattering as well as very reasonable saturation properties in Dirac-Brueckner calculations of nuclear matter. We include retardation terms to make these interactions covariant and readjust the coupling constants so as to maintain a reasonable description of NN scattering. In this case, we find the Dirac-Brueckner approximation to nuclear matter to be extremely overbound. The Bonn meson-exchange interactions provide a good fit to low-energy nucleon-nucleon scattering and the deuteron binding energy using a static interaction and the Thompson form of the reduced two-nucleon interaction. We have readjusted the coupling constants of the these interactions to obtain almost equivalent fits to the scattering data and deuteron binding energy with a static interaction and the Blankenbecler-Sugar form of the reduced two-nucleon propagator and using both forms of the propagator with a covariant interaction. Dirac-Brueckner calculations using the static interactions furnish saturation properties similar to those found for the Bonn interactions. The covariant interactions, on the contrary, yield extreme overbinding and do not show signs of saturation before our calculations diverge. One of the advantages claimed for Dirac mean field calculations over nonrelativistic ones has been the fact that they yield reasonable saturation properties without the necessity of a three-body interaction. This is usually credited to the three-body effects introduced by virtual scattering through the Dirac sea states. These are included, in part, through the Dirac form of the self-energy in our calculations. However, we have explicitly excluded their contribution to the Brueckner scattering kernel. Dirac-Brueckner calculations in which both the positive and negative energy states are included in the scattering kernel result in less binding than those that include only the positive-energy ones

  18. Accelerating Full Configuration Interaction Calculations for Nuclear Structure

    International Nuclear Information System (INIS)

    Yang, Chao; Sternberg, Philip; Maris, Pieter; Ng, Esmond; Sosonkina, Masha; Le, Hung Viet; Vary, James; Yang, Chao

    2008-01-01

    One of the emerging computational approaches in nuclear physics is the full configuration interaction (FCI) method for solving the many-body nuclear Hamiltonian in a sufficiently large single-particle basis space to obtain exact answers - either directly or by extrapolation. The lowest eigenvalues and corresponding eigenvectors for very large, sparse and unstructured nuclear Hamiltonian matrices are obtained and used to evaluate additional experimental quantities. These matrices pose a significant challenge to the design and implementation of efficient and scalable algorithms for obtaining solutions on massively parallel computer systems. In this paper, we describe the computational strategies employed in a state-of-the-art FCI code MFDn (Many Fermion Dynamics - nuclear) as well as techniques we recently developed to enhance the computational efficiency of MFDn. We will demonstrate the current capability of MFDn and report the latest performance improvement we have achieved. We will also outline our future research directions

  19. Motivation, amount of interaction, length of residence and ESL learners’ pragmatic competence

    Directory of Open Access Journals (Sweden)

    Zohre R Eslami

    2014-01-01

    Full Text Available This study examined how motivation for learning English, the amount of contact with English, and length of residence in the target language area affects Korean graduate students’ English pragmatic skills. The study attempted to account for differential pragmatic development among 50 graduate-level Korean students in relation to individual factors mentioned above. The data were collected using three types of elicitation instruments: a written background questionnaire, a discourse completion test, and the mini-Attitude/Motivation Test Battery. Descriptive and inferential statistics (correlation coefficients, and multiple regressions were used to analyze the data. The findings of the study revealed that (a the level of motivation had a positive and moderate relationship with the ESL learners’ L2 pragmatic competence and (b the amount of L2 contact and length of residence had only a weak and insignificant impact on the participants’ pragmatic competence.

  20. Effective calculation algorithm for nuclear chains of arbitrary length and branching

    International Nuclear Information System (INIS)

    Chirkov, V.A.; Mishanin, B.V.

    1994-01-01

    An effective algorithm for calculation of the isotope concentration in the spent nuclear fuel when it is kept in storage, is presented. Using the superposition principle and representing the transfer function in a rather compact form it becomes possible achieve high calculation speed and a moderate computer code size. The algorithm is applied for the calculation of activity, energy release and toxicity of heavy nuclides and products of their decay when the fuel is kept in storage. (authors). 1 ref., 4 tabs

  1. Nuclear Effects in Neutrino Interactions at Low Momentum Transfer

    Energy Technology Data Exchange (ETDEWEB)

    Miltenberger, Ethan Ryan [Univ. of Minnesota, Minneapolis, MN (United States)

    2015-05-01

    This is a study to identify predicted effects of the carbon nucleus environment on neutrino - nucleus interactions with low momentum transfer. A large sample of neutrino interaction data collected by the MINERvA experiment is analyzed to show the distribution of charged hadron energy in a region with low momentum transfer. These distributions reveal a major discrepancy between the data and a popular interaction model with only the simplest Fermi gas nuclear effects. Detailed analysis of systematic uncertainties due to energy scale and resolution can account for only a little of the discrepancy. Two additional nuclear model effects, a suppression/screening effect (RPA), and the addition of a meson exchange current process (MEC), are shown to improve the description of the data.

  2. Nuclear matter from effective quark-quark interaction.

    Science.gov (United States)

    Baldo, M; Fukukawa, K

    2014-12-12

    We study neutron matter and symmetric nuclear matter with the quark-meson model for the two-nucleon interaction. The Bethe-Bruckner-Goldstone many-body theory is used to describe the correlations up to the three hole-line approximation with no extra parameters. At variance with other nonrelativistic realistic interactions, the three hole-line contribution turns out to be non-negligible and to have a substantial saturation effect. The saturation point of nuclear matter, the compressibility, the symmetry energy, and its slope are within the phenomenological constraints. Since the interaction also reproduces fairly well the properties of the three-nucleon system, these results indicate that the explicit introduction of the quark degrees of freedom within the considered constituent quark model is expected to reduce the role of three-body forces.

  3. Construction of phosphorylation interaction networks by text mining of full-length articles using the eFIP system.

    Science.gov (United States)

    Tudor, Catalina O; Ross, Karen E; Li, Gang; Vijay-Shanker, K; Wu, Cathy H; Arighi, Cecilia N

    2015-01-01

    Protein phosphorylation is a reversible post-translational modification where a protein kinase adds a phosphate group to a protein, potentially regulating its function, localization and/or activity. Phosphorylation can affect protein-protein interactions (PPIs), abolishing interaction with previous binding partners or enabling new interactions. Extracting phosphorylation information coupled with PPI information from the scientific literature will facilitate the creation of phosphorylation interaction networks of kinases, substrates and interacting partners, toward knowledge discovery of functional outcomes of protein phosphorylation. Increasingly, PPI databases are interested in capturing the phosphorylation state of interacting partners. We have previously developed the eFIP (Extracting Functional Impact of Phosphorylation) text mining system, which identifies phosphorylated proteins and phosphorylation-dependent PPIs. In this work, we present several enhancements for the eFIP system: (i) text mining for full-length articles from the PubMed Central open-access collection; (ii) the integration of the RLIMS-P 2.0 system for the extraction of phosphorylation events with kinase, substrate and site information; (iii) the extension of the PPI module with new trigger words/phrases describing interactions and (iv) the addition of the iSimp tool for sentence simplification to aid in the matching of syntactic patterns. We enhance the website functionality to: (i) support searches based on protein roles (kinases, substrates, interacting partners) or using keywords; (ii) link protein entities to their corresponding UniProt identifiers if mapped and (iii) support visual exploration of phosphorylation interaction networks using Cytoscape. The evaluation of eFIP on full-length articles achieved 92.4% precision, 76.5% recall and 83.7% F-measure on 100 article sections. To demonstrate eFIP for knowledge extraction and discovery, we constructed phosphorylation-dependent interaction

  4. RNA substrate length as an indicator of exosome interactions in vivo [version 2; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Clémentine Delan-Forino

    2017-07-01

    Full Text Available Background: The exosome complex plays key roles in RNA processing and degradation in Eukaryotes and Archaea. Outstanding structural studies identified multiple pathways for RNA substrates into the exosome in vitro, but identifying the pathway followed by individual RNA species in vivo remains challenging. Methods: We attempted to address this question using RNase protection. In vivo RNA-protein crosslinking (CRAC was applied to the exosome component Rrp44/Dis3, which has both endonuclease and exonuclease activity. During CRAC, the exosome was purified under native conditions and subjected to RNase digestion, prior to protein denaturation and cDNA cloning. The resulting high-throughput sequence reads were stratified by length of the cDNA sequence. This should reflect RNA fragment lengths, and therefore the RNA region that was protected by exosome binding. We anticipated major read lengths of ~30nt and ~10nt, reflecting the “central channel” and “direct access” routes to the Rrp44 exonuclease active site observed in vitro. Results: Unexpectedly, no clear peak was observed at 30nt, whereas a broad peak was seen around 20nt. The expected ~10nt peak was seen, and showed strong elevation in strains lacking exonuclease activity. Unexpectedly, this peak was suppressed by point mutations in the Rrp44 endonuclease active site. This indicates that the short fragments are degraded by the exonuclease activity of Rrp44, but also suggests that at least some may be generated by endonuclease activity. Conclusions: The absence of 30nt protected fragments may reflect obligatory binding of cofactors at the entrance to the exosome central channel in vivo. The presence of ~20nt fragments apparently indicates an access route not yet reported from in vitro studies. Confident mapping of 10nt reads is challenging, but they are clearly derived from a subset of exosome targets. In particular, pre-rRNA species, which are major exosome targets, are strongly

  5. The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk

    OpenAIRE

    Kindinger, Lindsay M.; Bennett, Phillip R.; Lee, Yun S; Marchesi, Julian R.; Smith, Ann; Cacciatore, Stefano; Holmes, Elaine; Nicholson, Jeremy K.; Teoh, T. G.; MacIntyre, David A.

    2017-01-01

    Background Preterm birth is the primary cause of infant death worldwide. A short cervix in the second trimester of pregnancy is a risk factor for preterm birth. In specific patient cohorts, vaginal progesterone reduces this risk. Using 16S rRNA gene sequencing, we undertook a prospective study in women at risk of preterm birth (n?=?161) to assess (1) the relationship between vaginal microbiota and cervical length in the second trimester and preterm birth risk and (2) the impact of vaginal pro...

  6. Nuclear waste inventory characterization for mixer pumps and long length equipment removed from Hanford waste tanks

    International Nuclear Information System (INIS)

    Troyer, G.L.

    1998-01-01

    The removal and disposition of contaminated equipment from Hanford high-level nuclear waste tanks presents many challenges. One of which is the characterization of radioactive contaminants on components after removal. A defensible assessment of the radionuclide inventory of the components is required for disposal packaging and classification. As examples of this process, this paper discusses two projects: the withdrawal of thermocouple instrument tubes from Tank 101-AZ, and preparation for eventual replacement of the hydrogen mitigation mixer pump in Tank 101-SY. Emphasis is on the shielding analysis that supported the design of radiation detection systems and the interpolation of data recorded during the equipment retrieval operations

  7. Nuclear diagnostics of high intensity laser plasma interactions

    International Nuclear Information System (INIS)

    Krushelnick, K.; Santala, M.I.K.; Beg, F.N.; Clark, E.L.; Dangor, A.E.; Tatarakis, M.; Watts, I.; Wei, M.S.; Zepf, M.; Ledingham, K.W.D.; McCanny, T.; Spencer, I.; Clarke, R.J.; Norreys, P.A.

    2002-01-01

    Nuclear activation has been observed in materials exposed to energetic protons and heavy ions generated from high intensity laser-solid interactions (at focused intensities up to 5x10 19 W/cm 2 ). The energy spectrum of the protons is determined through the use of these nuclear activation techniques and is found to be consistent with other ion diagnostics. Heavy ion fusion reactions and large neutron fluxes from the (p, n) reactions were also observed. The reduction of proton emission and increase in heavy ion energy using heated targets was also observed

  8. Stress, depressive status and telomere length: Does social interaction and coping strategy play a mediating role?

    Science.gov (United States)

    Liu, Jia Jia; Wei, Ya Bin; Forsell, Yvonne; Lavebratt, Catharina

    2017-11-01

    Telomeres have been reported to be shorter in individuals exposed to psychosocial stress and in those with depression. Since negative environmental stress is a risk factor for depression, the present study tested whether stressors in childhood (CA) and recent adulthood (NLE) predicted telomere attrition directly and/or indirectly through individuals' depressive status 3-6 years before TL measurement; and then if social interaction and coping strategies in adulthood influenced the relationship between depressive status and TL. Participants were 337 individuals with a recent depression diagnosis and 574 screened controls that derived from a longitudinal population-based cohort study conducted in Stockholm, Sweden. Relative TL was determined using qPCR. Relationships between the key variables stressors, depressive status, social interaction, coping strategies and TL were explored by path analysis in males and females, adjusting for age. The key variables were correlated in expected directions. In females, depressive status and age had direct negative effects on TL (p social interaction (p = 0.005) and the coping strategy worry (p = 0.005). In females, no mediation effect of social interaction and coping strategy was detected. Only little of the TL variation was explained by the models. The environmental stress information was limited. Our findings propose gender-specific paths from environmental stressors through depressive status, social interaction and coping strategy to TL. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Chain length effects on the vibrational structure and molecular interactions in the liquid normal alkyl alcohols

    Science.gov (United States)

    Kiefer, Johannes; Wagenfeld, Sabine; Kerlé, Daniela

    2018-01-01

    Alkyl alcohols are widely used in academia, industry, and our everyday lives, e.g. as cleaning agents and solvents. Vibrational spectroscopy is commonly used to identify and quantify these compounds, but also to study their structure and behavior. However, a comprehensive investigation and comparison of all normal alkanols that are liquid at room temperature has not been performed, surprisingly. This study aims at bridging this gap with a combined experimental and computational effort. For this purpose, the alkyl alcohols from methanol to undecan-1-ol have been analyzed using infrared and Raman spectroscopy. A detailed assignment of the individual peaks is presented and the influence of the alkyl chain length on the hydrogen bonding network is discussed. A 2D vibrational mapping allows a straightforward visualization of the effects. The conclusions drawn from the experimental data are backed up with results from Monte Carlo simulations using the simulation package Cassandra.

  10. Analysis of genetic effects of nuclear-cytoplasmic interaction on quantitative traits: genetic model for diploid plants.

    Science.gov (United States)

    Han, Lide; Yang, Jian; Zhu, Jun

    2007-06-01

    A genetic model was proposed for simultaneously analyzing genetic effects of nuclear, cytoplasm, and nuclear-cytoplasmic interaction (NCI) as well as their genotype by environment (GE) interaction for quantitative traits of diploid plants. In the model, the NCI effects were further partitioned into additive and dominance nuclear-cytoplasmic interaction components. Mixed linear model approaches were used for statistical analysis. On the basis of diallel cross designs, Monte Carlo simulations showed that the genetic model was robust for estimating variance components under several situations without specific effects. Random genetic effects were predicted by an adjusted unbiased prediction (AUP) method. Data on four quantitative traits (boll number, lint percentage, fiber length, and micronaire) in Upland cotton (Gossypium hirsutum L.) were analyzed as a worked example to show the effectiveness of the model.

  11. The residual proton-neutron interaction and nuclear collectivity

    International Nuclear Information System (INIS)

    Casten, R.F.

    1990-01-01

    The essential role of the valence, residual p-n interaction in the development of collectivity, though long known in general terms, has recently become increasingly apparent. A brief review of the p-n interaction is given, including some very basic nuclear data that illustrate its effects and the phenomenological N p N n scheme and the P-factor. This is followed by a discussion of recent experimental extractions of p-n matrix elements throughout the periodic table and theoretical efforts to understand them, in terms of both Shell and Nilsson models. 20 refs., 13 figs

  12. Interactive nuclear plant analyzer for VVER-440 reactor

    International Nuclear Information System (INIS)

    Shier, W.; Horak, W.; Kennett, R.

    1992-05-01

    This document discusses an interactive nuclear plant analyzer (NPA) which has been developed for a VVER-440, Model 213 reactor for use in the training of plant personnel, the development and verification of plant operating procedures, and in the analysis of various anticipated operational occurrences and accident scenarios. This NPA is operational on an IBM RISC-6000 workstation and utilizes the RELAP5/MOD2 computer code for the calculation of the VVER-440 reactor response to the interactive commands initiated by the NPA operator

  13. Guidance for nuclear medicine staff on radiopharmaceuticals drug interaction

    International Nuclear Information System (INIS)

    Santos-Oliveira, Ralph

    2009-01-01

    Numerous drug interactions related to radiopharmaceuticals take place every day in hospitals many of which are not reported or detected. Information concerning this kind of reaction is not abundant, and nuclear medicine staff are usually overwhelmed by this information. To better understand this type of reaction, and to help nuclear medicine staff deal with it, a review of the literature was conducted. The results show that almost all of radiopharmaceuticals marketed around the world present drug interactions with a large variety of compounds. This suggests that a logical framework to make decisions based on reviews incorporating adverse reactions must be created. The review also showed that researchers undertaking a review of literature, or even a systematic review that incorporates drug interactions, must understand the rationale for the suggested methods and be able to implement them in their review. Additionally, a global effort should be made to report as many cases of drug interaction with radiopharmaceuticals as possible. With this, a complete picture of drug interactions with radiopharmaceuticals can be drawn. (author)

  14. Nuclear quadrupole interactions in ferroelectric compounds of HF181

    International Nuclear Information System (INIS)

    Kunzler, J.V.

    1971-01-01

    Measurements of nuclear quadrupole interaction constants in perovkite-type compounds of PbHfO 3 , SnhfO 3 , CaHfO 3 e SrHfO 3 have been performed using the perturbed angular correlation technique. A range of fundamental frequencies from 150 to 550 Megaradians persecond was determined. The variation of quadrupole constants has been discussed through the molecular orbital theory

  15. Heat transfer and mechanical interactions in fusion nuclear systems

    International Nuclear Information System (INIS)

    Nygren, R.E.

    1984-01-01

    This general review of design issues in heat transfer and mechanical interactions of the first wall, blanket and shield systems of tokamak and mirror fusion reactors begins with a brief introduction to fusion nuclear systems. The design issues are summarized in tables and the following examples are described to illustrate these concerns: the surface heating of limiters, heat transfer from solid breeders, MHD effects in liquid metal blankets, mechanical loads from electromagnetic transients and remote maintenance

  16. The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk.

    Science.gov (United States)

    Kindinger, Lindsay M; Bennett, Phillip R; Lee, Yun S; Marchesi, Julian R; Smith, Ann; Cacciatore, Stefano; Holmes, Elaine; Nicholson, Jeremy K; Teoh, T G; MacIntyre, David A

    2017-01-19

    Preterm birth is the primary cause of infant death worldwide. A short cervix in the second trimester of pregnancy is a risk factor for preterm birth. In specific patient cohorts, vaginal progesterone reduces this risk. Using 16S rRNA gene sequencing, we undertook a prospective study in women at risk of preterm birth (n = 161) to assess (1) the relationship between vaginal microbiota and cervical length in the second trimester and preterm birth risk and (2) the impact of vaginal progesterone on vaginal bacterial communities in women with a short cervix. Lactobacillus iners dominance at 16 weeks of gestation was significantly associated with both a short cervix vaginal dysbiosis. A longitudinal characterization of vaginal microbiota (vaginal progesterone (400 mg/OD, n = 25) versus controls (n = 42). Progesterone did not alter vaginal bacterial community structure nor reduce L. iners-associated preterm birth (vaginal microbiota at 16 weeks of gestation is a risk factor for preterm birth, whereas L. crispatus dominance is protective against preterm birth. Vaginal progesterone does not appear to impact the pregnancy vaginal microbiota. Patients and clinicians who may be concerned about "infection risk" associated with the use of a vaginal pessary during high-risk pregnancy can be reassured.

  17. Floral pipe: length in Petunia x hybrida heredability, number of genes and the interaction of the date with the character

    OpenAIRE

    Fatta, N.; Vazquez, M.; García, N.; Mascarini, A.; Grigioni, G.

    2007-01-01

    Petunia x hybrida, a floral summer of a economical importance in Buenos Aires, is nowadays produced with imported seed. The research presented is focused on the study of the feasibility to obtain locally competitive seed. The length of the floral pipe is a relevant character so the assay was designed in order to estimate the heredability, the number of genes intervener and the interactions with the date. The assay began with a F1 purchased from United States. In 2003, the F1 and F2 were sowed...

  18. Search for a particle with a long interaction length. [particle mandela to explain anomalous energy spectra at mountain altitude

    Science.gov (United States)

    Barrowes, S. C.; Huggett, R. W.; Jones, W. V.; Levit, L. B.; Porter, L. G.

    1975-01-01

    A search has been carried out for a long-lived particle having an interaction length lambda sub m equals 300 to 2000 gm/sq cm in air. Such a particle, called the mandela, has been proposed to explain an anomalous energy spectrum of particles observed near sea level with a shallow spectrometer. Data taken at mountain altitude with a deep spectrometer has been examined for compatibility with the existence of the mandela. Although data tend to favor the mandela hypothesis the results are not conclusive and appear to be explainable by conventional means.

  19. Calculation of media temperatures for nuclear sources in geologic depositories by a finite-length line source superposition model (FLLSSM)

    Energy Technology Data Exchange (ETDEWEB)

    Kays, W M; Hossaini-Hashemi, F [Stanford Univ., Palo Alto, CA (USA). Dept. of Mechanical Engineering; Busch, J S [Kaiser Engineers, Oakland, CA (USA)

    1982-02-01

    A linearized transient thermal conduction model was developed to economically determine media temperatures in geologic repositories for nuclear wastes. Individual canisters containing either high-level waste or spent fuel assemblies are represented as finite-length line sources in a continuous medium. The combined effects of multiple canisters in a representative storage pattern can be established in the medium at selected point of interest by superposition of the temperature rises calculated for each canister. A mathematical solution of the calculation for each separate source is given in this article, permitting a slow hand calculation. The full report, ONWI-94, contains the details of the computer code FLLSSM and its use, yielding the total solution in one computer output.

  20. Role amplification of the coulomb interaction in nuclear reactions

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Ashok; Soni, S K; Pancholi, S K; Gupta, S L [AN SSSR, Moscow. Radiotekhnicheskij Inst.

    1976-10-01

    The genarally adopted estimate of coulomb interaction in nuclear reactions based on the comparison of relative energies of real particles participating in the reaction with the coulomb barrier has been shown to provide wrong presentation of the role of coulomb interaction in the reaction mechanism. The relative energy of particles participating in virtual processes forming the reaction mechanism and its relation to the coulomb barrier turn out to be tens of per cent less than for the particles in an inlet channel. This is the main reason of increasing the role of coulomb interaction in the reaction mechanism. This increase is particularly significant for nuclei with large charges, in particular, in heavy ion reaction.

  1. Hyperon interaction in free space and nuclear matter

    Energy Technology Data Exchange (ETDEWEB)

    Dhar, Madhumita; Lenske, Horst [Institute for Theoretical Physics, Justus- Liebig-University Giessen (Germany)

    2015-07-01

    Baryon-baryon interactions within the SU(3)-octet are investigated in free space and nuclear matter.A meson exchange model based on SU(3) symmetry is used for determining the interaction. The Bethe-Salpeter equations are solved in a 3-D reduction scheme. In-medium effect has been incorporated by including a two particle Pauli projector operator in the scattering equation. The coupling of the various channels of total strangeness S and conserved total charge is studied in detail. Special attention is paid to the physical thresholds. The density dependence of interaction is clearly seen in the variation of the in-medium low-energy parameters. The approach is compared to descriptions derived from chiral-EFT and other meson-exchange models e.g. the Nijmegen and the Juelich model.

  2. Hyperon interaction in free space and nuclear matter

    Energy Technology Data Exchange (ETDEWEB)

    Dhar, Madhumita [Justus-Liebig University Giessen (Germany); Lenske, Horst [Justus-Liebig University Giessen (Germany); GSI, Darmstadt (Germany)

    2016-07-01

    A new approach to the SU(3) flavour symmetric meson-exchange model is introduced to describe free space baryon-baryon interaction. The Bethe-Salpeter equations are solved in a 3-D reduction scheme. The coupling of the various channels of total strangeness S and conserved total charge Q is studied in detail. Special attention is paid to the physical thresholds. The derived vacuum interaction has then been used to derive nuclear medium effect by employing the Pauli projector operator in 3-D reduced Bethe-Salpeter equation. The in-medium properties of the interaction are clearly seen in the variation of the in-medium low-energy parameters as a function of density.

  3. Interactive nuclear plant analyzer for the VVER-440 reactor

    International Nuclear Information System (INIS)

    Shier, W.; Kennett, R.

    1993-01-01

    An interactive nuclear plant analyzer (NPA) has been developed for a VVER-440 model 213 reactor for use in the training of plant personnel, the development and verification of plant operating procedures, and in the analysis of various anticipated operational occurrences and accident scenarios. This NPA is operational on an IBM RISC-6000 workstation and utilizes the RELAP5/MOD2 computer code for the calculation of the VVER-440 reactor response to the interactive commands initiated by the NPA operator. Results of the interactive calculation can be through the user-defined, digital display of various plant parameters and through color changes that reflect changes in primary system fluid temperatures, fuel and clad temperatures, and the temperatures of other metal structures. In addition, changes in the status of various components and system can be initiated and/or displayed both numerically and graphically on the mask

  4. Skyrme interaction to second order in nuclear matter

    Science.gov (United States)

    Kaiser, N.

    2015-09-01

    Based on the phenomenological Skyrme interaction various density-dependent nuclear matter quantities are calculated up to second order in many-body perturbation theory. The spin-orbit term as well as two tensor terms contribute at second order to the energy per particle. The simultaneous calculation of the isotropic Fermi-liquid parameters provides a rigorous check through the validity of the Landau relations. It is found that published results for these second order contributions are incorrect in most cases. In particular, interference terms between s-wave and p-wave components of the interaction can contribute only to (isospin or spin) asymmetry energies. Even with nine adjustable parameters, one does not obtain a good description of the empirical nuclear matter saturation curve in the low density region 0\\lt ρ \\lt 2{ρ }0. The reason for this feature is the too strong density-dependence {ρ }8/3 of several second-order contributions. The inclusion of the density-dependent term \\frac{1}{6}{t}3{ρ }1/6 is therefore indispensable for a realistic description of nuclear matter in the Skyrme framework.

  5. DNA interactions with a Methylene Blue redox indicator depend on the DNA length and are sequence specific.

    Science.gov (United States)

    Farjami, Elaheh; Clima, Lilia; Gothelf, Kurt V; Ferapontova, Elena E

    2010-06-01

    A DNA molecular beacon approach was used for the analysis of interactions between DNA and Methylene Blue (MB) as a redox indicator of a hybridization event. DNA hairpin structures of different length and guanine (G) content were immobilized onto gold electrodes in their folded states through the alkanethiol linker at the 5'-end. Binding of MB to the folded hairpin DNA was electrochemically studied and compared with binding to the duplex structure formed by hybridization of the hairpin DNA to a complementary DNA strand. Variation of the electrochemical signal from the DNA-MB complex was shown to depend primarily on the DNA length and sequence used: the G-C base pairs were the preferential sites of MB binding in the duplex. For short 20 nts long DNA sequences, the increased electrochemical response from MB bound to the duplex structure was consistent with the increased amount of bound and electrochemically readable MB molecules (i.e. MB molecules that are available for the electron transfer (ET) reaction with the electrode). With longer DNA sequences, the balance between the amounts of the electrochemically readable MB molecules bound to the hairpin DNA and to the hybrid was opposite: a part of the MB molecules bound to the long-sequence DNA duplex seem to be electrochemically mute due to long ET distance. The increasing electrochemical response from MB bound to the short-length DNA hybrid contrasts with the decreasing signal from MB bound to the long-length DNA hybrid and allows an "off"-"on" genosensor development.

  6. Guidance for nuclear medicine staff on radiopharmaceuticals drug interaction

    Directory of Open Access Journals (Sweden)

    Ralph Santos-Oliveira

    2009-12-01

    Full Text Available Numerous drug interactions related to radiopharmaceuticals take place every day in hospitals many of which are not reported or detected. Information concerning this kind of reaction is not abundant, and nuclear medicine staff are usually overwhelmed by this information. To better understand this type of reaction, and to help nuclear medicine staff deal with it, a review of the literature was conducted. The results show that almost all of radiopharmaceuticals marketed around the world present drug interactions with a large variety of compounds. This suggests that a logical framework to make decisions based on reviews incorporating adverse reactions must be created. The review also showed that researchers undertaking a review of literature, or even a systematic review that incorporates drug interactions, must understand the rationale for the suggested methods and be able to implement them in their review. Additionally, a global effort should be made to report as many cases of drug interaction with radiopharmaceuticals as possible. With this, a complete picture of drug interactions with radiopharmaceuticals can be drawn.Diversos casos de interações medicamentosas com radiofármacos ocorrem diariamente na rotina hospitalar, contudo muitos deles não são notificados ou mesmo percebidos. Informações a respeito desse tipo de reação não é abundante e os profissionais da medicina nuclear muitas vezes estão assoberbados por essas informações. De modo a entender esse tipo de reação e auxiliar a medicina nuclear a lidar com essa situação uma revisão da literatura foi realizada. Os resultados mostraram que a totalidade dos radiofármacos comercializados no mundo apresentam interação medicamentosa com uma enorme variedade de outros medicamentos. Dessa forma sugere-se que revisões sobre radiofármacos inclua um capítulo sobre efeitos adversos. Além disso, um esforço mundial para notificar efeitos adversos deve ser realizado, pois somente

  7. Effects of Gogny type interactions on the nuclear flow

    International Nuclear Information System (INIS)

    Sebille, F.; De La Mota, V.; Jouault, B.; Schuck, P.

    1995-01-01

    A flow analysis on symmetric and asymmetric reactions from 100 to 400 MeV/n is performed in the framework of the semi-classical Landau-Vlasov approach. In this energy range our results present two different trends. At lower energies it is governed by the momentum dependence of the nuclear optical potential, whereas at higher energies its density dependence plays a crucial role leading to a rather pronounced sensitivity of the incompressibility modulus. The non-locality of the nuclear interaction is relevant for asymmetric colliding systems. With an incompressibility modulus in the vicinity of 200 MeV, an excellent quantitative description of the flow behavior with incident energy and impact parameter or the system mass is provided. (authors)., 26 refs., 6 figs., 3 tabs

  8. Interaction of HTLV-1 Tax protein with calreticulin: implications for Tax nuclear export and secretion.

    Science.gov (United States)

    Alefantis, Timothy; Flaig, Katherine E; Wigdahl, Brian; Jain, Pooja

    2007-05-01

    Human T cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 transcriptional transactivator protein Tax plays an integral role in virus replication and disease progression. Traditionally, Tax is described as a nuclear protein where it performs its primary role as a transcriptional transactivator. However, recent studies have clearly shown that Tax can also be localized to the cytoplasm where it has been shown to interact with a number of host transcription factors most notably NF-kappaB, constitutive expression of which is directly related to the T cell transforming properties of Tax in ATL patients. The presence of a functional nuclear export signal (NES) within Tax and the secretion of full-length Tax have also been demonstrated previously. Additionally, release of Tax from HTLV-1-infected cells and the presence of cell-free Tax was demonstrated in the CSF of HAM/TSP patients suggesting that the progression to HAM/TSP might be mediated by the ability of Tax to function as an extracellular cytokine. Therefore, in both ATL and HAM/TSP Tax nuclear export and nucleocytoplasmic shuttling may play a critical role, the mechanism of which remains unknown. In this study, we have demonstrated that the calcium binding protein calreticulin interacts with Tax by co-immunoprecipitation. This interaction was found to localize to a region at or near the nuclear membrane. In addition, differential expression of calreticulin was demonstrated in various cell types that correlated with their ability to retain cytoplasmic Tax, particularly in astrocytes. Finally, a comparison of a number of HTLV-1-infected T cell lines to non-infected T cells revealed higher expression of calreticulin in infected cells implicating a direct role for this protein in HTLV-1 infection.

  9. Role of pn-pairs interaction in nuclear structure

    International Nuclear Information System (INIS)

    Nie, G.K.

    2004-01-01

    Full text: The nuclear structure approach is based on theory of interaction of pn-pairs with suggestion that proton and neutron of one pair have the same nuclear potential. In frame of this model nuclei with N=Z were analyzed in [1,2]. In [1] radii of position of last proton were estimated on difference of proton and neutron separation energies. In [2] a phenomenological formula for calculation of binding energy of alpha- cluster nuclei was found. Present work is devoted to developing the nuclear structure model. Coulomb energy of nuclei with N=Z has been found from sum of differences of separation energies of protons and neutrons belonging to one pairs. From analysis of nuclei 12 C and 16 O the value of energy of Coulomb repulsion between 2 α -clusters has been estimated equal to ε C α =1.925 MeV [3], which means that value of nuclear (meson) interaction between 2 α -clusters is expected to be ε m αα = ε cov αα + ε C α =4.350 MeV. From suggestion that energy of long range Coulomb repulsion is compensated by surface tension energy an equation has been found to calculate radius of position of last proton on value of Z. Charge radii of nuclei from 58 Ni to 208 Bi and further have been calculated with difference from experimental ones in several hundredths of fm. In the approach binding energy of excess neutrons stays beyond the consideration. Therefore, in calculation of binding energies of nuclei the experimental values of separation energies of excess neutrons are used. There is a good agreement between calculated values of binding energies of some isotopes of all known elements as well as separation energies of alpha particle and deuteron and experimental data. The difference from experimental binding energy in most of the cases is about 0.5% and less

  10. Effective Electrostatic Interactions Between Two Overall Neutral Surfaces with Quenched Charge Heterogeneity Over Atomic Length Scale

    Science.gov (United States)

    Zhou, S.

    2017-12-01

    the salt ion; whereas if the 1:1 type electrolyte and the symmetrical patterns are considered, then the opposite may be the case. All of these findings can be explained self-consistently from several perspectives: an excess adsorption of the salt ions (induced by the surface charge separation) serving to raise the osmotic pressure between the plates, configuration fine-tuning in the thinner ion adsorption layer driven by the energy decrease principle, direct Coulombic interactions operating between charged objects on the two face-to-face plates involved, and net charge strength in the ion adsorption layer responsible for the net electrostatic repulsion.

  11. Structure-soil-structure interaction of nuclear structures

    International Nuclear Information System (INIS)

    Snyder, M.D.; Shaw, D.E.; Hall, J.R. Jr.

    1975-01-01

    Structure-to-structure interaction resulting from coupling of the foundations through the soil has traditionally been neglected in the seismic analysis of nuclear power plants. This paper examines the phenomenon and available methods of analytical treatment, including finite element and lumped parameter methods. Finite element techniques have lead to the treatment of through soil coupling of structural foundations using two dimensional plane strain models owing to the difficulty of considering three dimensional finite element models. The coupling problem is treated by means of a lumped parameter model derived from elastic half-space considerations. Consequently, the method is applicable to the interaction of any number of foundations and allows the simultaneous application of tri-directional excitation. The method entails the idealization of interacting structures as lumped mass/shear beams with lumped soil springs and dampers beneath each foundation plus a coupling matrix between the interacting foundations. Utilizing classical elastic half-space methods, the individual foundation soil springs and dampers may be derived, accounting for the effects of embedment and soil layering, analogous to the methods used for single soil-structure, interaction problems. The coupling matrix is derived by generating influence coefficients based on the geometric relationship of the structures using classical half-space solutions. The influence coefficients form the coupling flexibility matrix which is inverted to yield the coupling matrix for the lumped parameter model

  12. Time-reversal-noninvariant, parity-conserving nuclear interactions

    International Nuclear Information System (INIS)

    Haxton, W.C.; Hoering, A.; Washington Univ., Seattle, WA; Melbourne Univ., Parkville, VIC

    1993-01-01

    In this paper the authors quantify the relationship between compound nucleus (CN) and electric dipole moment (edm) constraints on long-ranged time-reversal-noninvariant (TRNI), parity-conserving (PC) interactions. It begins by reviewing the work that has been done in compound nuclei. In the second section, it considers the general form of the TRNI PC interaction in meson exchange models. In the third section discusses one mechanism for generating an atomic edm, a TRNI PC nuclear interaction mediate by ρ exchange coupled with Z exchange between atomic electrons and the nucleus. While a variety of other mechanisms can similarly generate edms from TRNI PC interactions this example has some interesting experimental consequences. The limits extracted are then translated into a constraint on α, the ratio of typical TRNI and TRI N N matrix elements. It is concluded that such atomic edm limits on TRNI PC interactions are at least comparable to those obtained in the best CN studies. These limits from long-distance contributions to edms are then compared to the stringent bounds obtained recently by Conti and Khriplovich from studies of short-ranged mechanisms. 37 refs., 2 figs

  13. Nuclear hyperfine interactions and chemical bonding in high TC superconductors

    International Nuclear Information System (INIS)

    Danon, J.

    1987-01-01

    Nuclear quadrupole resonances of Cu 63 and Fe 57 Moessbauer spectroscopy of the high temperature superconductor YBa 2 Cu 3 O 7-γ e described together with synchrotron radiation studies of the copper oxidation states in this material. The Moessbauer spectra of 57 Fe in the two distinct crystallographic sites of the Cu atoms in YBa 2 Cu 3 O 7-γ are very similar from the quadrupole coupling point of view although exhibiting markedly different values for the isomer shift. The role of oxygen vacancies in the hyperfine interactions is discussed. (author) [pt

  14. Nuclear Fusion Research Understanding Plasma-Surface Interactions

    CERN Document Server

    Clark, Robert E.H

    2005-01-01

    It became clear in the early days of fusion research that the effects of the containment vessel (erosion of "impurities") degrade the overall fusion plasma performance. Progress in controlled nuclear fusion research over the last decade has led to magnetically confined plasmas that, in turn, are sufficiently powerful to damage the vessel structures over its lifetime. This book reviews current understanding and concepts to deal with this remaining critical design issue for fusion reactors. It reviews both progress and open questions, largely in terms of available and sought-after plasma-surface interaction data and atomic/molecular data related to these "plasma edge" issues.

  15. Study of the Λ(1116 interaction in cold nuclear matter

    Directory of Open Access Journals (Sweden)

    Arnold Oliver

    2014-03-01

    Full Text Available The interaction of Λ hyperons with baryonic nuclear matter at saturation density is expected to be attractive. The interaction strength was extracted from hypernuclei data. A different approach to obtain the potential depth of the Λ mean-field potential is to compare experimental data with transport simulations. We analyze experimental data of Λ hyperons measured with the HADES detector in p+93Nb reactions with a kinetic beam energy of 3.5 GeV carried by the proton. The high statistic of measured Λ hyperons allows us to perform a double differential analysis in Lorentz-invariant observables of transverse momentum and rapidity. We present the analysis method and a comparison with simulations.

  16. Theory of nuclear quadrupole interactions in solid hydrogen fluoride

    International Nuclear Information System (INIS)

    Mohamed, N.S.; Sahoo, N.; Das, T.P.; Kelires, P.C.

    1990-01-01

    The nuclear quadrupole interaction of 19 F * (I=5/2) nucleus in solid hydrogen fluoride has been studied using the Hartree Fock cluster technique to understand the influence of both intrachain hydrogen bonding effects and the weak interchain interaction. On the basis of our investigations, the 34.04 MHz coupling constant observed by TDPAD measurements has been ascribed to the bulk solid while the observed 40.13 MHz coupling constant is suggested as arising from a small two- or three-molecule cluster produced during the proton irradiation process. Two alternate explanations are offered for the origin of coupling constants close to 40 MHz in a number of solid hydrocarbons containing hydrogen and fluorine ligands. (orig.)

  17. Alternate nuclear waste forms and interactions in geologic media

    International Nuclear Information System (INIS)

    Boatner, L.A.; Battle, G.C. Jr.

    1981-04-01

    The primary purposes of the conference on Alternate Nuclear Waste Forms and Interactions in Geologic Media were: First, to provide an opportunity for a review of the status of the research on some of the candidate alternative waste forms; second, to provide an opportunity for comparing the characteristics of alternate waste forms to those of glasses; and third, to stimulate increased interactions between those research groups that were engaged in a more basic approach to characterizing waste forms and those who were concerned with more applied aspects such as the processing of these materials. The motivating philosophy behind this third purpose of the conference was based on the idea that by operating from the soundest possible fundamental base for any of the candidate waste forms, hopefully any future unpleasant surprise - such as that alluded to earlier in the case of glass waste forms - could be avoided. Separate abstracts have been prepared for individual papers for inclusion in the Energy Data Base

  18. Effective pion--nucleon interaction in nuclear matter

    International Nuclear Information System (INIS)

    Celenza, L.S.; Liu, L.C.; Nutt, W.; Shakin, C.M.

    1976-01-01

    We discuss the modification of the interaction between a pion and a nucleon in the presence of an infinite medium of nucleons (nuclear matter). The theory presented here is covariant and is relevant to the calculation of the pion--nucleus optical potential. The specific effects considered are the modifications of the nucleon propagator due to the Pauli principle and the modification of the pion and nucleon propagators due to collisions with nucleons of the medium. We also discuss in detail the pion self-energy in the medium, paying close attention to off-shell effects. These latter effects are particularly important because of the rapid variation with energy of the fundamental pion--nucleon interaction. Numerical results are presented, the main feature being the appearance of a significant damping width for the (3, 3) resonance

  19. Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors

    International Nuclear Information System (INIS)

    Kiss, A.; Li, L.; Gettemeier, T.; Venkatesh, L.K.

    2003-01-01

    Human immunodeficiency virus type 1 (HIV-1) Rev-mediated nuclear export of viral RNAs involves the interaction of its leucine-rich nuclear export sequence (NES) with nuclear cofactors. In yeast two-hybrid screens of a human lymph node derived cDNA expression library, we identified the human nucleoporin Nup98 as a highly specific and potent interactor of the Rev NES. Using an extensive panel of nuclear export positive and negative mutants of the functionally homologous NESs of the HIV-1 Rev, human T cell leukemia virus type 1 (HTLV-1) Rex, and equine infectious anemia virus (EIAV) Rev proteins, physiologically significant interaction of hNup98 with the various NESs was demonstrated. Missense mutations in the yeast nuclear export factor Crm1p that abrogated Rev NES interaction with the XXFG repeat-containing nucleoporin, Rab/hRIP, had minimal effects on the interaction of GLFG repeat-containing hNup98. Functional analysis of Nup98 domains required for nuclear localization demonstrated that the entire ORF was required for efficient incorporation into the nuclear envelope. A putative nuclear localization signal was identified downstream of the GLFG repeat region. Whereas overexpression of both full-length Nup98 and the amino-terminal GLFG repeat region, but not the unique carboxy-terminal region, induced significant suppression of HIV unspliced RNA export, lower levels of exogenous Nup98 expression resulted in a relatively modest increase in unspliced RNA export. These results suggest a physiological role for hNup98 in modulating Rev-dependent RNA export during HIV infection

  20. THIEF: An interactive simulation of nuclear materials safeguards

    Energy Technology Data Exchange (ETDEWEB)

    Stanbro, W. D.

    1990-01-01

    The safeguards community is facing an era in which it will be called upon to tighten protection of nuclear material. At the same time, it is probable that safeguards will face more competition for available resources from other activities such as environmental cleanup. To exist in this era, it will be necessary to understand and coordinate all aspects of the safeguards system. Because of the complexity of the interactions involved, this process puts a severe burden on designers and operators of safeguards systems. This paper presents a simulation tool developed at the Los Alamos National Laboratory to allow users to examine the interactions among safeguards elements as they apply to combating the insider threat. The tool consists of a microcomputer-based simulation in which the user takes the role of the insider trying to remove nuclear material from a facility. The safeguards system is run by the computer and consists of both physical protection and MC A computer elements. All data elements describing a scenario can be altered by the user. The program can aid in training, as well as in developing threat scenarios. 4 refs.

  1. Equation of state of dense nuclear matter and neutron star structure from nuclear chiral interactions

    Science.gov (United States)

    Bombaci, Ignazio; Logoteta, Domenico

    2018-02-01

    Aims: We report a new microscopic equation of state (EOS) of dense symmetric nuclear matter, pure neutron matter, and asymmetric and β-stable nuclear matter at zero temperature using recent realistic two-body and three-body nuclear interactions derived in the framework of chiral perturbation theory (ChPT) and including the Δ(1232) isobar intermediate state. This EOS is provided in tabular form and in parametrized form ready for use in numerical general relativity simulations of binary neutron star merging. Here we use our new EOS for β-stable nuclear matter to compute various structural properties of non-rotating neutron stars. Methods: The EOS is derived using the Brueckner-Bethe-Goldstone quantum many-body theory in the Brueckner-Hartree-Fock approximation. Neutron star properties are next computed solving numerically the Tolman-Oppenheimer-Volkov structure equations. Results: Our EOS models are able to reproduce the empirical saturation point of symmetric nuclear matter, the symmetry energy Esym, and its slope parameter L at the empirical saturation density n0. In addition, our EOS models are compatible with experimental data from collisions between heavy nuclei at energies ranging from a few tens of MeV up to several hundreds of MeV per nucleon. These experiments provide a selective test for constraining the nuclear EOS up to 4n0. Our EOS models are consistent with present measured neutron star masses and particularly with the mass M = 2.01 ± 0.04 M⊙ of the neutron stars in PSR J0348+0432.

  2. Inhibition of nuclear T3 binding by fatty acids: dependence on chain length, unsaturated bonds, cis-trans configuration and esterification

    NARCIS (Netherlands)

    Wiersinga, W. M.; Platvoet-ter Schiphorst, M.

    1990-01-01

    1. Fatty acids have the capacity for inhibition of nuclear T3 binding (INB). The present studies were undertaken to describe the INB-activity of fatty acids as a function of chain length, unsaturated bonds, cis-trans configuration, and esterification. 2. Isolated rat liver nuclei were incubated with

  3. Nuclear medicine installations supervisors interactive course (CD-ROM)

    International Nuclear Information System (INIS)

    Williart, A.; Shaw, M.; Tellez, M.

    2000-01-01

    The professionals who work as Nuclear Medicine Installations Supervisors need a suitable training. This training must be based on the guidelines of the C.S.N. (the Spanish Agency for Nuclear Safety). The traditional training courses must comply with a set of requirements, that not always is possible to get: They are given in a settled place. They are developed during a time, more or less lengthy. This time is pre-established. However, the persons willing to follow these courses have some difficulties with the place and the time. Many of them do not live near the places where the courses are given, in general in big cities, while there are Nuclear Medicine Installations scattered through all Spain. Moreover in some occasions they have not available time to attend the courses. Many times, faced with so many obstacles, the option is not to do the suitable training course. In order to solve this kind of problems we offer an Interactive Training Course (supported by CD-ROM). The course contents are based on Spanish Regulations and on the Safety Guide, established by C.S.N., for approval Radioactive Installations Supervisors Training Courses. This guide includes General Topics for Radioactive Installations and Specific Subjects for Nuclear Medicine. (General topics) Basic knowledge on the fundamental concepts on the action and nature of Ionizing Radiations, their risks and preventions. The ionizing radiations. Biological effects of ionizing radiations. Radiological protection. Legislation on radioactive installations. (Specific Subjects) Knowledge on the radiological risks associated to the proper techniques in the specific field of application. In our case the specific field is Nuclear Medicine Installations, where the radioactive sources are used for diagnostic or for therapy. Specific legal and administrative aspects. Non-encapsulated radioactive sources. Associated radiological risks to the use of non-encapsulated sources. Installations design. Operative procedures

  4. Interaction and dynamics of (alkylamide + electrolyte) deep eutectics: Dependence on alkyl chain-length, temperature, and anion identity

    International Nuclear Information System (INIS)

    Guchhait, Biswajit; Das, Suman; Daschakraborty, Snehasis; Biswas, Ranjit

    2014-01-01

    Here we investigate the solute-medium interaction and solute-centered dynamics in (RCONH 2 + LiX) deep eutectics (DEs) via carrying out time-resolved fluorescence measurements and all-atom molecular dynamics simulations at various temperatures. Alkylamides (RCONH 2 ) considered are acetamide (CH 3 CONH 2 ), propionamide (CH 3 CH 2 CONH 2 ), and butyramide (CH 3 CH 2 CH 2 CONH 2 ); the electrolytes (LiX) are lithium perchlorate (LiClO 4 ), lithium bromide (LiBr), and lithium nitrate (LiNO 3 ). Differential scanning calorimetric measurements reveal glass transition temperatures (T g ) of these DEs are ∼195 K and show a very weak dependence on alkyl chain-length and electrolyte identity. Time-resolved and steady state fluorescence measurements with these DEs have been carried out at six-to-nine different temperatures that are ∼100–150 K above their individual T g s. Four different solute probes providing a good spread of fluorescence lifetimes have been employed in steady state measurements, revealing strong excitation wavelength dependence of probe fluorescence emission peak frequencies. Extent of this dependence, which shows sensitivity to anion identity, has been found to increase with increase of amide chain-length and decrease of probe lifetime. Time-resolved measurements reveal strong fractional power dependence of average rates for solute solvation and rotation with fraction power being relatively smaller (stronger viscosity decoupling) for DEs containing longer amide and larger (weaker decoupling) for DEs containing perchlorate anion. Representative all-atom molecular dynamics simulations of (CH 3 CONH 2 + LiX) DEs at different temperatures reveal strongly stretched exponential relaxation of wavevector dependent acetamide self dynamic structure factor with time constants dependent both on ion identity and temperature, providing justification for explaining the fluorescence results in terms of temporal heterogeneity and amide clustering in these multi

  5. Interactive virtual laboratory for distance education in nuclear engineering

    International Nuclear Information System (INIS)

    Jain, P.; Stubbins, J.; Uddin, R.

    2006-01-01

    A real time, distance lab module is being developed and implemented in the Dept. of Nuclear, Plasma and Radiological Engineering at the Univ. of Illinois at Urbana-Champaign. This internet based system allows remote personnel to watch the experiments, acquire data, and interact with on-site personnel. The e-lab broadcasts not only the live scenes of laboratory and experiments, but also the real time data and plots being measured and displayed in graphical and other formats. Moreover, use of LabVIEW's remote front panel feature allows communications between the local lab and remote client so that, if permitted, remote client can control part or all of the experiment in real-time. (authors)

  6. Interactive graphics analysis system for nuclear engineering applications

    International Nuclear Information System (INIS)

    Danchak, M.; Moyer, W.R.; Becker, M.

    1973-01-01

    From working with continuous slowing down theory, the need was recognized for a system which allowed rapid calculation of the theoretical flux, instant comparison with experiment and a simple means of iterating on the slowing down parameters to force flux agreement and reflect cross section modification. Similar requirements exist in other areas of nuclear work for streamlining and simplifying the data analysis process. As a solution, a unique interactive graphics analysis system (RIGAS) was devised to allow a user to calculate, display, compare, manipulate and modify his data without requiring any programming on his part. This was accomplished by establishing human primacy, through extensive human factor considerations, and designing a man-machine dialogue which responds to the mere push of a button. This system results in an instrument which maximizes man's decision making capability and the computer's speed to improve graphic communication and data analysis. (14 figs) (U.S.)

  7. Description of superdeformed nuclear states in the interacting boson model

    International Nuclear Information System (INIS)

    Liu, Y.; Zhao, E.; Liu, Y.; Song, J.; Liu, Y.; Sun, H.; Zhao, E.; Liu, Y.; Sun, H.

    1997-01-01

    We show in this paper that the superdeformed nuclear states can be described with a four parameter formula in the spirit of the perturbated SU(3) limit of the sdg IBM. The E2 transition γ-ray energies, the dynamical moments of inertia of the lowest superdeformed (SD) bands in even-even Hg, Pb, Gd, and Dy isotopes, and the energy differences ΔE γ -ΔE γ ref of the SD band 1 of 194 Hg are calculated. The calculated results agree with experimental data well. This indicates that the SD states are governed by a rotational interaction plus a perturbation with SO sdg (5) symmetry. The perturbation causing the ΔI=4 bifurcation to emerge in the ΔI=2 superdeformed rotational band may then possess SO sdg (5) symmetry. copyright 1997 The American Physical Society

  8. Nuclear envelope and genome interactions in cell fate

    Science.gov (United States)

    Talamas, Jessica A.; Capelson, Maya

    2015-01-01

    The eukaryotic cell nucleus houses an organism’s genome and is the location within the cell where all signaling induced and development-driven gene expression programs are ultimately specified. The genome is enclosed and separated from the cytoplasm by the nuclear envelope (NE), a double-lipid membrane bilayer, which contains a large variety of trans-membrane and associated protein complexes. In recent years, research regarding multiple aspects of the cell nucleus points to a highly dynamic and coordinated concert of efforts between chromatin and the NE in regulation of gene expression. Details of how this concert is orchestrated and how it directs cell differentiation and disease are coming to light at a rapid pace. Here we review existing and emerging concepts of how interactions between the genome and the NE may contribute to tissue specific gene expression programs to determine cell fate. PMID:25852741

  9. Modelling operator cognitive interactions in nuclear power plant safety evaluation

    International Nuclear Information System (INIS)

    Senders, J.W.; Moray, N.; Smiley, A.; Sellen, A.

    1985-08-01

    The overall objectives of the study were to review methods which are applicable to the analysis of control room operator cognitive interactions in nuclear plant safety evaluations and to indicate where future research effort in this area should be directed. This report is based on an exhaustive search and review of the literature on NPP (Nuclear Power Plant) operator error, human error, human cognitive function, and on human performance. A number of methods which have been proposed for the estimation of data for probabilistic risk analysis have been examined and have been found wanting. None addresses the problem of diagnosis error per se. Virtually all are concerned with the more easily detected and identified errors of action. None addresses underlying cause and mechanism. It is these mechanisms which must be understood if diagnosis errors and other cognitive errors are to be controlled and predicted. We have attempted to overcome the deficiencies of earlier work and have constructed a model/taxonomy, EXHUME, which we consider to be exhaustive. This construct has proved to be fruitful in organizing our thinking about the kinds of error that can occur and the nature of self-correcting mechanisms, and has guided our thinking in suggesting a research program which can provide the data needed for quantification of cognitive error rates and of the effects of mitigating efforts. In addition a preliminary outline of EMBED, a causal model of error, is given based on general behavioural research into perception, attention, memory, and decision making. 184 refs

  10. Resonant Electromagnetic Interaction in Low Energy Nuclear Reactions

    Science.gov (United States)

    Chubb, Scott

    2008-03-01

    Basic ideas about how resonant electromagnetic interaction (EMI) can take place in finite solids are reviewed. These ideas not only provide a basis for conventional, electron energy band theory (which explains charge and heat transport in solids), but they also explain how through finite size effects, it is possible to create many of the kinds of effects envisioned by Giuliano Preparata. The underlying formalism predicts that the orientation of the external fields in the SPAWAR protocolootnotetextKrivit, Steven B., New Energy Times, 2007, issue 21, item 10. http://newenergytimes.com/news/2007/NET21.htm^,ootnotetextSzpak, S.; Mosier-Boss, P.A.; Gordon, F.E. Further evidence of nuclear reactions in the Pd lattice: emission of charged particles. Naturwissenschaften 94,511(2007)..has direct bearing on the emission of high-energy particles. Resonant EMI also implies that nano-scale solids, of a particular size, provide an optimal environment for initiating Low Energy Nuclear Reactions (LENR) in the PdD system.

  11. Investigation of nuclear interactions around 20 TeV

    Energy Technology Data Exchange (ETDEWEB)

    Sato, Y [Waseda Univ., Tokyo (Japan). Science and Engineering Research Lab.; Sugimoto, H; Saito, T

    1976-12-01

    Nuclear interactions at a mean energy of about 20 TeV are studied by means of a nuclear emulsion chamber with jet producer. In the present analysis, particular emphasis is placed on the experimental condition. The transverse momentum spectrum of secondary ..gamma.. rays is approximated by a single exponential in a range of 0.3

  12. Electron and nuclear spin interactions in the optical spectra of single GaAs quantum dots.

    Science.gov (United States)

    Gammon, D; Efros, A L; Kennedy, T A; Rosen, M; Katzer, D S; Park, D; Brown, S W; Korenev, V L; Merkulov, I A

    2001-05-28

    Fine and hyperfine splittings arising from electron, hole, and nuclear spin interactions in the magneto-optical spectra of individual localized excitons are studied. We explain the magnetic field dependence of the energy splitting through competition between Zeeman, exchange, and hyperfine interactions. An unexpectedly small hyperfine contribution to the splitting close to zero applied field is described well by the interplay between fluctuations of the hyperfine field experienced by the nuclear spin and nuclear dipole/dipole interactions.

  13. Role of chromosome stability and telomere length in the production of viable cell lines for somatic cell nuclear transfer

    Directory of Open Access Journals (Sweden)

    Betts Dean H

    2006-08-01

    Full Text Available Abstract Background Somatic cell nuclear transfer (SCNT provides an appealing alternative for the preservation of genetic material in non-domestic and endangered species. An important prerequisite for successful SCNT is the availability of good quality donor cells, as normal embryo development is dependent upon proper reprogramming of the donor genome so that embryonic genes can be appropriately expressed. The characteristics of donor cell lines and their ability to produce embryos by SCNT were evaluated by testing the effects of tissue sample collection (DART biopsy, PUNCH biopsy, post-mortem EAR sample and culture initiation (explant, collagenase digestion techniques. Results Differences in initial sample size based on sample collection technique had an effect on the amount of time necessary for achieving primary confluence and the number of population doublings (PDL produced. Thus, DART and PUNCH biopsies resulted in cultures with decreased lifespans (50 PDL and chromosomally stable (>70% normal cells at 20 PDL cultures produced by post-mortem EAR samples. Chromosome stability was influenced by sample collection technique and was dependent upon the culture's initial telomere length and its rate of shortening over cell passages. Following SCNT, short-lived cultures resulted in significantly lower blastocyst development (≤ 0.9% compared to highly proliferative cultures (11.8%. Chromosome stability and sample collection technique were significant factors in determining blastocyst development outcome. Conclusion These data demonstrate the influence of culture establishment techniques on cell culture characteristics, including the viability, longevity and normality of cells. The identification of a quantifiable marker associated with SCNT embryo developmental potential, chromosome stability, provides a means by which cell culture conditions can be monitored and improved.

  14. Human-machine interaction in nuclear power plants

    International Nuclear Information System (INIS)

    Yoshikawa, Hidekazu

    2005-01-01

    Advanced nuclear power plants are generally large complex systems automated by computers. Whenever a rate plant emergency occurs the plant operators must cope with the emergency under severe mental stress without committing any fatal errors. Furthermore, the operators must train to improve and maintain their ability to cope with every conceivable situation, though it is almost impossible to be fully prepared for an infinite variety of situations. In view of the limited capability of operators in emergency situations, there has been a new approach to preventing the human error caused by improper human-machine interaction. The new approach has been triggered by the introduction of advanced information systems that help operators recognize and counteract plant emergencies. In this paper, the adverse effect of automation in human-machine systems is explained. The discussion then focuses on how to configure a joint human-machine system for ideal human-machine interaction. Finally, there is a new proposal on how to organize technologies that recognize the different states of such a joint human-machine system

  15. Hyperon interaction in free space and nuclear matter within a SU(3) based meson exchange model

    Energy Technology Data Exchange (ETDEWEB)

    Dhar, Madhumita

    2016-06-15

    To establish the connection between free space and in-medium hyperon-nucleon interactions is the central issue of this thesis. The guiding principle is flavor SU(3) symmetry which is exploited at various levels. In first step hyperon-nucleon and hyperon- hyperon interaction boson exchange potential in free space are introduced. A new parameter set applicable for the complete baryon octet has been derived leading to an updated one-boson- exchange model, utilizing SU(3) flavor symmetry, optimizing the number of free parameters involved, and revising the set of mesons included. The scalar, pseudoscalar, and vector SU(3) meson octets are taken into account. T-matrices are calculated by solving numerically coupled linear systems of Lippmann-Schwinger equations obtained from a 3-D reduced Bethe-Salpeter equation. Coupling constants were determined by χ{sup 2} fits to the world set of scattering data. A good description of the few available data is achieved within the imposed SU(3) constraints. Having at hand a consistently derived vacuum interaction we extend the approach next to investigations of the in-medium properties of hyperon interaction, avoiding any further adjustments. Medium effect in infinite nuclear matter are treated microscopically by recalculating T-matrices by an medium-modified system of Lippmann-Schwinger equations. A particular important role is played by the Pauli projector accounting for the exclusion principle. The presence of a background medium induces a weakening of the vacuum interaction amplitudes. Especially coupled channel mixing is found to be affected sensitively by medium. Investigation on scattering lengths and effective range parameters are revealing the density dependence of the interaction on a quantitative level.

  16. Direct interaction in nuclear reactions: a theory; L'interaction directe dans les reactions nucleaires: theorie

    Energy Technology Data Exchange (ETDEWEB)

    Dominicis, C.T. de [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1959-07-01

    General treatment of the foundations of direct interaction in nuclear reactions; representation of the instantaneous elastic scattering amplitude by the scattering amplitude due to a complex potential; expansion of the instantaneous inelastic scattering amplitude and discussion of the 1. Bohr approximation (distorted waves) contribution to individual and collective states of excitation. (author) [French] Expose general sur les fondements de l'interaction directe dans les reactions nucleaires; representation de l'amplitude de diffusion instantanee elastique par celle due a un potentiel complexe; developpement de l'amplitude de diffusion instantanee inelastique et discussion de la contribution de la premiere approximation de Bohr (sur des distendues) a l'excitation d'etats individuels et collectifs. (auteur)

  17. Longitudinal patterns and response lengths of algae in riverine ecosystems: A model analysis emphasising benthic-pelagic interactions.

    Science.gov (United States)

    Jäger, Christoph G; Borchardt, Dietrich

    2018-04-07

    In riverine ecosystems primary production is principally possible in two habitats: in the benthic layer by sessile algae and in the surface water by planktonic algae being transported downstream. The relevance of these two habitats generally changes along the rivers' continuum. However, analyses of the interaction of algae in these two habitats and their controlling factors in riverine ecosystems are, so far, very rare. We use a simplified advection-diffusion model system combined with ecological process kinetics to analyse the interaction of benthic and planktonic algae and nutrients along idealised streams and rivers at regional to large scales. Because many of the underlying processes affecting algal dynamics are influenced by depth, we focus particularly on the impact of river depth on this interaction. At constant environmental conditions all state variables approach stable spatial equilibria along the river, independent of the boundary conditions at the upstream end. Because our model is very robust against changes of turbulent diffusion and stream velocity, these spatial equilibria can be analysed by a simplified ordinary differential equation (ode) version of our model. This model variant reveals that at shallower river depths, phytoplankton can exist only when it is subsidised by detaching benthic algae, and in turn, at deeper river depths, benthic algae can exist only in low biomasses which are subsidised by sinking planktonic algae. We generalise the spatial dynamics of the model system using different conditions at the upstream end of the model, which mimic various natural or anthropogenic factors (pristine source, dam, inflow of a waste water treatment plant, and dilution from e.g. a tributary) and analyse how these scenarios influence different aspects of the longitudinal spatial dynamics of the full spatial model: the relation of spatial equilibrium to spatial maximum, the distance to the spatial maximum, and the response length. Generally, our

  18. Impact of water dilution and cation tail length on ionic liquid characteristics: Interplay between polar and non-polar interactions

    International Nuclear Information System (INIS)

    Hegde, Govind A.; Bharadwaj, Vivek S.; Kinsinger, Corey L.; Schutt, Timothy C.; Pisierra, Nichole R.; Maupin, C. Mark

    2016-01-01

    The recalcitrance of lignocellulosic biomass poses a major challenge that hinders the economical utilization of biomass for the production of biofuel, plastics, and chemicals. Ionic liquids have become a promising solvent that addresses many issues in both the pretreatment process and the hydrolysis of the glycosidic bond for the deconstruction of cellulosic materials. However, to make the use of ionic liquids economically viable, either the cost of ionic liquids must be reduced, or a less expensive solvent (e.g., water) may be added to reduce the overall amount of ionic liquid used in addition to reducing the viscosity of the binary liquid mixture. In this work, we employ atomistic molecular dynamics simulations to investigate the impact of water dilution on the overall liquid structure and properties of three imidazolium based ionic liquids. It is found that ionic liquid-water mixtures exhibit characteristics that can be grouped into two distinct regions, which are a function of the ionic liquid concentration. The trends observed in each region are found to correlate with the ordering in the local structure of the ionic liquid that arises from the dynamic interactions between the ion pairs. Simulation results suggest that there is a high level of local ordering in the molecular structure at high concentrations of ionic liquids that is driven by the aggregation of the cationic tails and the anion-water interactions. It is found that as the concentration of ionic liquids in the binary mixture is decreased, there is a point at which the competing self and cross interaction energies between the ionic liquid and water shifts away from a cation-anion dominated regime, which results in a significant change in the mixture properties. This break point, which occurs around 75% w/w ionic liquids, corresponds to the point at which water molecules percolate into the ionic liquid network disrupting the ionic liquids’ nanostructure. It is observed that as the cationic alkyl

  19. Resonant Interaction, Approximate Symmetry, and Electromagnetic Interaction (EMI) in Low Energy Nuclear Reactions (LENR)

    Science.gov (United States)

    Chubb, Scott

    2007-03-01

    Only recently (talk by P.A. Mosier-Boss et al, in this session) has it become possible to trigger high energy particle emission and Excess Heat, on demand, in LENR involving PdD. Also, most nuclear physicists are bothered by the fact that the dominant reaction appears to be related to the least common deuteron(d) fusion reaction,d+d ->α+γ. A clear consensus about the underlying effect has also been illusive. One reason for this involves confusion about the approximate (SU2) symmetry: The fact that all d-d fusion reactions conserve isospin has been widely assumed to mean the dynamics is driven by the strong force interaction (SFI), NOT EMI. Thus, most nuclear physicists assume: 1. EMI is static; 2. Dominant reactions have smallest changes in incident kinetic energy (T); and (because of 2), d+d ->α+γ is suppressed. But this assumes a stronger form of SU2 symmetry than is present; d+d ->α+γ reactions are suppressed not because of large changes in T but because the interaction potential involves EMI, is dynamic (not static), the SFI is static, and because the two incident deuterons must have approximate Bose Exchange symmetry and vanishing spin. A generalization of this idea involves a resonant form of reaction, similar to the de-excitation of an atom. These and related (broken gauge) symmetry EMI effects on LENR are discussed.

  20. Interaction and dynamics of (alkylamide + electrolyte) deep eutectics: Dependence on alkyl chain-length, temperature, and anion identity

    Energy Technology Data Exchange (ETDEWEB)

    Guchhait, Biswajit; Das, Suman; Daschakraborty, Snehasis; Biswas, Ranjit, E-mail: ranjit@bose.res.in [Department of Chemical, Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block-JD, Sector-III, Salt Lake, Kolkata 700098 (India)

    2014-03-14

    Here we investigate the solute-medium interaction and solute-centered dynamics in (RCONH{sub 2} + LiX) deep eutectics (DEs) via carrying out time-resolved fluorescence measurements and all-atom molecular dynamics simulations at various temperatures. Alkylamides (RCONH{sub 2}) considered are acetamide (CH{sub 3}CONH{sub 2}), propionamide (CH{sub 3}CH{sub 2}CONH{sub 2}), and butyramide (CH{sub 3}CH{sub 2}CH{sub 2}CONH{sub 2}); the electrolytes (LiX) are lithium perchlorate (LiClO{sub 4}), lithium bromide (LiBr), and lithium nitrate (LiNO{sub 3}). Differential scanning calorimetric measurements reveal glass transition temperatures (T{sub g}) of these DEs are ∼195 K and show a very weak dependence on alkyl chain-length and electrolyte identity. Time-resolved and steady state fluorescence measurements with these DEs have been carried out at six-to-nine different temperatures that are ∼100–150 K above their individual T{sub g}s. Four different solute probes providing a good spread of fluorescence lifetimes have been employed in steady state measurements, revealing strong excitation wavelength dependence of probe fluorescence emission peak frequencies. Extent of this dependence, which shows sensitivity to anion identity, has been found to increase with increase of amide chain-length and decrease of probe lifetime. Time-resolved measurements reveal strong fractional power dependence of average rates for solute solvation and rotation with fraction power being relatively smaller (stronger viscosity decoupling) for DEs containing longer amide and larger (weaker decoupling) for DEs containing perchlorate anion. Representative all-atom molecular dynamics simulations of (CH{sub 3}CONH{sub 2} + LiX) DEs at different temperatures reveal strongly stretched exponential relaxation of wavevector dependent acetamide self dynamic structure factor with time constants dependent both on ion identity and temperature, providing justification for explaining the fluorescence results in

  1. Influence of the Debye length on the interaction of a small molecule-modified Au nanoparticle with a surface-bound bioreceptor.

    Science.gov (United States)

    Bukar, Natalia; Zhao, Sandy Shuo; Charbonneau, David M; Pelletier, Joelle N; Masson, Jean-Francois

    2014-05-18

    We report that a shorter Debye length and, as a consequence, decreased colloidal stability are required for the molecular interaction of folic acid-modified Au nanoparticles (Au NPs) to occur on a surface-bound receptor, human dihydrofolate reductase (hDHFR). The interaction measured using surface plasmon resonance (SPR) sensing was optimal in a phosphate buffer at pH 6 and ionic strength exceeding 300 mM. Under these conditions, the aggregation constant of the Au NPs was approximately 10(4) M(-1) s(-1) and the Debye length was below 1 nm, on the same length scale as the size of the folate anion (approximately 0.8 nm). Longer Debye lengths led to poorer SPR responses, revealing a reduced affinity of the folic acid-modified Au NPs for hDHFR. While high colloidal stability of Au NPs is desired in most applications, these conditions may hinder molecular interactions due to Debye lengths exceeding the size of the ligand and thus preventing close interactions with the surface-bound molecular receptor.

  2. Nonlocal electrostatics in ionic liquids: The key to an understanding of the screening decay length and screened interactions

    Science.gov (United States)

    Kjellander, Roland

    2016-09-01

    Screened electrostatic interactions in ionic liquids are investigated by means of exact statistical mechanical analysis combined with physical arguments that enhance the transparency and conceptual accessibility of the analysis and results. The constituent ions and immersed particles in the liquid can have arbitrary shapes and any internal charge distributions. The decay of the screened electrostatic potential and the free energy of interaction in ionic liquids can be exponentially damped oscillatory (like in molten simple salts) as well as plain exponential and long-ranged (like in dilute electrolyte solutions). Both behaviors are in agreement with the exact statistical mechanical analysis and reasons for their appearances are investigated. Exact but surprisingly simple expressions for the decay parameter κ of the screened electrostatics are obtained, which replace the classical expression for the Debye-Hückel parameter κDH (the reciprocal Debye length). The expressions are applicable both for cases with plain exponential and oscillatory behaviors. The key importance of nonlocal electrostatics is thereby demonstrated explicitly. Dielectric properties of ionic liquids and other electrolytes are investigated, in particular the static dielectric function ɛ ˜ ( k ) and some effective relative permittivities ( Er eff and Er ∗ ), which take roles that the dielectric constant ɛr has for polar liquids consisting of electroneutral molecules. The dielectric constant in the latter case, which is the limit of ɛ ˜ ( k ) when the wave number k → 0, can be expressed solely in terms of dipolar features of the molecules. In contrast to this, the effective dielectric permittivities of ionic liquids have contributions also from quadrupolar, octupolar, and higher multipolar features of the constituent ions. The "dielectric constant" of electrolytes does not exist since ɛ ˜ ( k ) → ∞ when k → 0, a well-known effect of perfect screening. The effective relative

  3. Heat energy from hydrogen-metal nuclear interactions

    Energy Technology Data Exchange (ETDEWEB)

    Hadjichristos, John [Defkalion GT SA, 1140 Homer Street, Suite 250, Vancouver BC V682X6 (Canada); Gluck, Peter [Retired from INCDTIM Cluj-Napoca in 1999 (Romania)

    2013-11-13

    The discovery of the Fleischmann-Pons Effect in 1989, a promise of an abundant, cheap and clean energy source was premature in the sense that theoretical knowledge, relative technologies and the experimental tools necessary for understanding and for scale-up still were not available. Therefore the field, despite efforts and diversification remained quasi-stagnant, the effect (a scientific certainty) being of low intensity leading to mainstream science to reject the phenomenon and not supporting its study. Recently however, the situation has changed, a new paradigm is in statunascendi and the obstacles are systematically removed by innovative approaches. Defkalion, a Greek company (that recently moved in Canada for faster progress) has elaborated an original technology for the Ni-H system [1-3]. It is about the activation of hydrogen and creation of nuclear active nano-cavities in the metal through a multi-stage interaction, materializing some recent breakthrough announcements in nanotechnology, superconductivity, plasma physics, astrophysics and material science. A pre-industrial generator and a novel mass-spectrometry instrumentations were created. Simultaneously, a meta-theory of phenomena was sketched in collaboration with Prof. Y. Kim (Purdue U)

  4. Nuclear many-body problem with repulsive hard core interactions

    Energy Technology Data Exchange (ETDEWEB)

    Haddad, L M

    1965-07-01

    The nuclear many-body problem is considered using the perturbation-theoretic approach of Brueckner and collaborators. This approach is outlined with particular attention paid to the graphical representation of the terms in the perturbation expansion. The problem is transformed to centre-of-mass coordinates in configuration space and difficulties involved in ordinary methods of solution of the resulting equation are discussed. A new technique, the 'reference spectrum method', devised by Bethe, Brandow and Petschek in an attempt to simplify the numerical work in presented. The basic equations are derived in this approximation and considering the repulsive hard core part of the interaction only, the effective mass is calculated at high momentum (using the same energy spectrum for both 'particle' and 'hole' states). The result of 0.87m is in agreement with that of Bethe et al. A more complete treatment using the reference spectrum method in introduced and a self-consistent set of equations is established for the reference spectrum parameters again for the case of hard core repulsions. (author)

  5. Polarization phenomena of nuclear force and weak interaction

    International Nuclear Information System (INIS)

    Konuma, Michitsugu

    1982-01-01

    As one of the projects at the National Laboratory of High Energy Physics (KEK), the measurement of parity non-conservation component in nuclear force was proposed. The theoretical survey of this proposal is reported. The non-relativistic parity non-conserving potential between nucleons can be obtained from the interaction between a quark and a gauge boson. The wave function of a nucleus, which includes the inverse components of the parity, can be written. A practical experiment was designed. The mixing of the inverse components and the interference of an inverse component in the 1042 keV and 1081 keV levels of F 18 may produce the parity non-conservation. The processes which suggest the existence of parity non-conservation were studied. The processes are the circular polarization of gamma-ray emitted from a nucleus, the angular distribution of gamma-ray emitted from polarized nuclei, the collision of the proton beam with helicity of plus and minus on other nuclei, the spin rotation of neutrons, and the alpha decay of the parity non-conservation. The preliminary results of the experiment on the effects of parity non-conservation in the collision process of polarized proton beam have been reported, and the theoretical analyses were performed. The violation of parity conservation in large momentum collision is discussed. The comparison of the theoretical results with the experimental ones is presented. (Kato, T.)

  6. Heat energy from hydrogen-metal nuclear interactions

    International Nuclear Information System (INIS)

    Hadjichristos, John; Gluck, Peter

    2013-01-01

    The discovery of the Fleischmann-Pons Effect in 1989, a promise of an abundant, cheap and clean energy source was premature in the sense that theoretical knowledge, relative technologies and the experimental tools necessary for understanding and for scale-up still were not available. Therefore the field, despite efforts and diversification remained quasi-stagnant, the effect (a scientific certainty) being of low intensity leading to mainstream science to reject the phenomenon and not supporting its study. Recently however, the situation has changed, a new paradigm is in statunascendi and the obstacles are systematically removed by innovative approaches. Defkalion, a Greek company (that recently moved in Canada for faster progress) has elaborated an original technology for the Ni-H system [1-3]. It is about the activation of hydrogen and creation of nuclear active nano-cavities in the metal through a multi-stage interaction, materializing some recent breakthrough announcements in nanotechnology, superconductivity, plasma physics, astrophysics and material science. A pre-industrial generator and a novel mass-spectrometry instrumentations were created. Simultaneously, a meta-theory of phenomena was sketched in collaboration with Prof. Y. Kim (Purdue U)

  7. Quantitative theory of channeling particle diffusion in transverse energy in the presence of nuclear scattering and direct evaluation of dechanneling length

    Energy Technology Data Exchange (ETDEWEB)

    Tikhomirov, Victor V. [Belarusian State University, Institute for Nuclear Problems, Minsk (Belarus)

    2017-07-15

    A refined equation for channeling particle diffusion in transverse energy taking into consideration large-angle scattering by nuclei is suggested. This equation is reduced to the Sturm-Liouville problem, allowing one to reveal both the origin and the limitations of the dechanneling length notion. The values of the latter are evaluated for both positively and negatively charged particles of various energies. New features of the dechanneling dynamics of positively charged particles are also revealed. First, it is demonstrated that the dechanneling length notion is completely inapplicable for their nuclear dechanneling process. Second, the effective electron dechanneling length of positively charged particle varies more than twice converging to a constant asymptotic value only at the depth exceeding the latter. (orig.)

  8. Interaction of electromagnetic pulse with commercial nuclear-power-plant systems

    Energy Technology Data Exchange (ETDEWEB)

    Ericson, D.M. Jr.; Strawe, D.F.; Sandberg, S.J.; Jones, V.K.; Rensner, G.D.; Shoup, R.W.; Hanson, R.J.; Williams, C.B.

    1983-02-01

    This study examines the interaction of the electromagnetic pulse from a high altitude nuclear burst with commercial nuclear power plant systems. The potential vulnerability of systems required for safe shutdown of a specific nuclear power plant are explored. EMP signal coupling, induced plant response and component damage thresholds are established using techniques developed over several decades under Defense Nuclear Agency sponsorship. A limited test program was conducted to verify the coupling analysis technique as applied to a nuclear power plant. The results are extended, insofar as possible, to other nuclear plants.

  9. Interaction of electromagnetic pulse with commercial nuclear-power-plant systems

    International Nuclear Information System (INIS)

    Ericson, D.M. Jr.; Strawe, D.F.; Sandberg, S.J.; Jones, V.K.; Rensner, G.D.; Shoup, R.W.; Hanson, R.J.; Williams, C.B.

    1983-02-01

    This study examines the interaction of the electromagnetic pulse from a high altitude nuclear burst with commercial nuclear power plant systems. The potential vulnerability of systems required for safe shutdown of a specific nuclear power plant are explored. EMP signal coupling, induced plant response and component damage thresholds are established using techniques developed over several decades under Defense Nuclear Agency sponsorship. A limited test program was conducted to verify the coupling analysis technique as applied to a nuclear power plant. The results are extended, insofar as possible, to other nuclear plants

  10. Antiproton-nucleus interaction and nuclear E2 resonance effect in molybdenum and neodymium isotopes

    International Nuclear Information System (INIS)

    Kanert, W.

    1986-01-01

    Antiprotonix X-radiation from 92 Mo, 94 Mo, 95 Mo, 98 Mo, 100 Mo and 146 Nd, 148 Nd was measured with Ge detectors at the LEAR (CERN). The nuclear E2 resonance effect (configuration mixing by dynamic electric quadrupole interaction) was for the first time observed in antiprotonic atoms. It effects in 94 Mo, 95 Mo, and 98 Mo a mixing of the atomic levels (7,6) and (5,4). From the resulting weakening of the antiprotonic X-ray line (7→6) in comparison with the nonresonant isotope 92 Mo information on the effects of the strong interaction in the (5,4) level was obtained which is in Mo not directly observable. The absorption widths by strong interactions in the level (6,5) resulted for 92 Mo, 94 Mo, 95 Mo, and 98 Mo to 1.4±0.3 keV, 2.3±0.9 keV, 1.9±0.4 keV, and 2.3±0.7 keV, the energy shifts by strong interactions to 0.46±0.08 keV, 0.64±0.22 keV, 0.74±0.12 keV, and 0.55±0.16 keV. In the nonresonant isotope 92 Mo the absorption width of the level (7,6) to 19.5±1.2 eV. A fit of the effective scattering length to the data for 92 Mo resulted anti a = (0.25+3.05i) fm. In 100 Mo the predicted case of strong coupling could be experimentally established by the nearly complete extinction of the line (8→7) and the broadening of the line (9→8). In 148 Nd the nuclear E2 resonance effect effects a mixing of the levels (9,8) and (8,6) and by this a reduction of the line (9→8) in comparison to 146 Nd. For this isotope information on the effects of the strong interaction could be extracted separately for the fine structure components. (orig.) [de

  11. Interaction of a finite-length ion beam with a background plasma: Reflected ions at the quasi-parallel bow shock

    International Nuclear Information System (INIS)

    Onsager, T.G.; Winske, D.; Thomsen, M.F.

    1991-01-01

    The coupling of a finite-length, field-aligned, ion beam with a uniform background plasma is investigated using one-dimensional hybrid computer simulations. The finite-length beam is used to study the interaction between the incident solar wind and ions reflected from the Earth's quasi-parallel bow shock, where the reflection process may vary with time. The coupling between the reflected ions and the solar wind is relevant to ion heating at the bow shock and possibly to the formation of hot, flow anomalies and re-formation of the shock itself. The authors find that although there are many similarities between the instabilities driven by the finite-length beam and those predicted by linear theory for an infinite, homogeneous beam, there are also some important differences. Consistent with linear theory, the waves which dominate the interaction are the electromagnetic right-hand polarized resonant and nonresonant modes. However, in addition to the instability growth rates, the length of time that the waves are in contact with the beam is also an important factor in determining which wave mode will dominate the interaction. Whereas linear theory predicts the nonresonant mode to have the larger growth rate for the parameters they investigate, with finite-length beam they find that both the nonresonant and resonant modes contribute to the interaction. They find that the interaction will result in strong coupling, where a significant fraction of the available free energy is converted into thermal energy in a short time, provided the beam is sufficiently dense or sufficiently long

  12. A High Performance Block Eigensolver for Nuclear Configuration Interaction Calculations

    International Nuclear Information System (INIS)

    Aktulga, Hasan Metin; Afibuzzaman, Md.; Williams, Samuel; Buluc, Aydin; Shao, Meiyue

    2017-01-01

    As on-node parallelism increases and the performance gap between the processor and the memory system widens, achieving high performance in large-scale scientific applications requires an architecture-aware design of algorithms and solvers. We focus on the eigenvalue problem arising in nuclear Configuration Interaction (CI) calculations, where a few extreme eigenpairs of a sparse symmetric matrix are needed. Here, we consider a block iterative eigensolver whose main computational kernels are the multiplication of a sparse matrix with multiple vectors (SpMM), and tall-skinny matrix operations. We then present techniques to significantly improve the SpMM and the transpose operation SpMM T by using the compressed sparse blocks (CSB) format. We achieve 3-4× speedup on the requisite operations over good implementations with the commonly used compressed sparse row (CSR) format. We develop a performance model that allows us to correctly estimate the performance of our SpMM kernel implementations, and we identify cache bandwidth as a potential performance bottleneck beyond DRAM. We also analyze and optimize the performance of LOBPCG kernels (inner product and linear combinations on multiple vectors) and show up to 15× speedup over using high performance BLAS libraries for these operations. The resulting high performance LOBPCG solver achieves 1.4× to 1.8× speedup over the existing Lanczos solver on a series of CI computations on high-end multicore architectures (Intel Xeons). We also analyze the performance of our techniques on an Intel Xeon Phi Knights Corner (KNC) processor.

  13. On sensitivity of gamma families to the model of nuclear interaction

    International Nuclear Information System (INIS)

    Krys, A.; Tomaszewski, A.; Wrotniak, J.A.

    1980-01-01

    A variety of 5 different models of nuclear interaction has been used in a Monte Carlo simulation of nuclear and electromagnetic showers in the atmosphere. The gamma families obtained from this simulation were processed in a way, analogous to one employed in analysis of Pamir experimental results. The sensitivity of observed pattern to the nuclear interaction model assumptions was investigated. Such sensitivity, though not a strong one, was found. In case of longitudinal (or energetical) family characteristics, the changes in nuclear interaction should be really large, if they were to be reflected in the experimental data -with all methodical error possibilities. The transverse characteristics of gamma families are more sensitive to the assumed transverse momentum distribution, but they feel the longitudinal features of nuclear interaction as well. Additionally, there was tested the dependence of observed family pattern on some methodical effects (resolving power of X-ray film, radial cut-off and energy underestimation.) (author)

  14. Interaction study of rice stripe virus proteins reveals a region of the nucleocapsid protein (NP) required for NP self-interaction and nuclear localization.

    Science.gov (United States)

    Lian, Sen; Cho, Won Kyong; Jo, Yeonhwa; Kim, Sang-Min; Kim, Kook-Hyung

    2014-04-01

    Rice stripe virus (RSV), which belongs to the genus Tenuivirus, is an emergent virus problem. The RSV genome is composed of four single-strand RNAs (RNA1-RNA4) and encodes seven proteins. We investigated interactions between six of the RSV proteins by yeast-two hybrid (Y2H) assay in vitro and by bimolecular fluorescence complementation (BiFC) in planta. Y2H identified self-interaction of the nucleocapsid protein (NP) and NS3, while BiFC revealed self-interaction of NP, NS3, and NCP. To identify regions(s) and/or crucial amino acid (aa) residues required for NP self-interaction, we generated various truncated and aa substitution mutants. Y2H assay showed that the N-terminal region of NP (aa 1-56) is necessary for NP self-interaction. Further analysis with substitution mutants demonstrated that additional aa residues located at 42-47 affected their interaction with full-length NP. These results indicate that the N-terminal region (aa 1-36 and 42-47) is required for NP self-interaction. BiFC and co-localization studies showed that the region required for NP self-interaction is also required for NP localization at the nucleus. Overall, our results indicate that the N-terminal region (aa 1-47) of the NP is important for NP self-interaction and that six aa residues (42-47) are essential for both NP self-interaction and nuclear localization. Copyright © 2014 Elsevier B.V. All rights reserved.

  15. Diagnosis of Weibel instability evolution in the rear surface density scale lengths of laser solid interactions via proton acceleration

    International Nuclear Information System (INIS)

    Scott, G G; Brenner, C M; Clarke, R J; Green, J S; Heathcote, R I; Rusby, D R; McKenna, P; Neely, D; Bagnoud, V; Zielbauer, B; Gonzalez-Izquierdo, B; Powell, H W

    2017-01-01

    It is shown for the first time that the spatial and temporal distribution of laser accelerated protons can be used as a diagnostic of Weibel instability presence and evolution in the rear surface scale lengths of a solid density target. Numerical modelling shows that when a fast electron beam is injected into a decreasing density gradient on the target rear side, a magnetic instability is seeded with an evolution which is strongly dependent on the density scale length. This is manifested in the acceleration of a filamented proton beam, where the degree of filamentation is also found to be dependent on the target rear scale length. Furthermore, the energy dependent spatial distribution of the accelerated proton beam is shown to provide information on the instability evolution on the picosecond timescale over which the protons are accelerated. Experimentally, this is investigated by using a controlled prepulse to introduce a target rear scale length, which is varied by altering the time delay with respect to the main pulse, and similar trends are measured. This work is particularly pertinent to applications using laser pulse durations of tens of picoseconds, or where a micron level density scale length is present on the rear of a solid target, such as proton-driven fast ignition, as the resultant instability may affect the uniformity of fuel energy coupling. (paper)

  16. Does working memory change with age? The interactions of concurrent articulation with the effects of word length and acoustic confusion.

    Science.gov (United States)

    Bireta, Tamra J; Fine, Hope C; Vanwormer, Lisa A

    2013-01-01

    The effects of acoustic confusion (phonological similarity), word length, and concurrent articulation (articulatory suppression) are cited as support for Working Memory's phonological loop component (e.g., Baddeley, 2000 , Psychonomic Bulletin and Review, 7, 544). Research has focused on younger adults, with no studies examining whether concurrent articulation reduces the word length and acoustic confusion effects among older adults. In the current study, younger and older adults were given lists of similar and dissimilar letters (Experiment 1) or long and short words (Experiment 2) for immediate serial reconstruction of order. Items were presented visually or auditorily, with or without concurrent articulation. As expected, younger and older adults demonstrated effects of acoustic confusion, word length, and concurrent articulation. Further, concurrent articulation reduced the effects of acoustic confusion and word length equally for younger and older adults. This suggests that age-related differences occur in overall performance, but do not reflect an age-related deficiency in the functioning of the phonological loop component of working memory.

  17. Low-frequency fatigue, post-tetanic potentiation and their interaction at different muscle lengths following eccentric exercise.

    NARCIS (Netherlands)

    Rijkelijkhuizen, J.M.; de Ruiter, C.J.; Huijing, P.A.J.B.M.; de Haan, A.

    2005-01-01

    Low-frequency fatigue (LFF) and post-tetanic potentiation (PTP) were quantified at different muscle lengths in rat medial gastrocnemius (GM) muscle. In situ experiments were performed on GM muscle-tendon complexes of anaesthetised (urethane, 1.5 g kg

  18. Grasp and index finger reach zone during one-handed smartphone rear interaction: effects of task type, phone width and hand length.

    Science.gov (United States)

    Lee, Songil; Kyung, Gyouhyung; Lee, Jungyong; Moon, Seung Ki; Park, Kyoung Jong

    2016-11-01

    Recently, some smartphones have introduced index finger interaction functions on the rear surface. The current study investigated the effects of task type, phone width, and hand length on grasp, index finger reach zone, discomfort, and muscle activation during such interaction. We considered five interaction tasks (neutral, comfortable, maximum, vertical, and horizontal strokes), two device widths (60 and 90 mm) and three hand lengths. Horizontal (vertical) strokes deviated from the horizontal axis in the range from -10.8° to -13.5° (81.6-88.4°). Maximum strokes appeared to be excessive as these caused 43.8% greater discomfort than did neutral strokes. The 90-mm width also appeared to be excessive as it resulted in 12.3% increased discomfort relative to the 60-mm width. The small-hand group reported 11.9-18.2% higher discomfort ratings, and the percent maximum voluntary exertion of their flexor digitorum superficialis muscle, pertaining to index finger flexion, was also 6.4% higher. These findings should be considered to make smartphone rear interaction more comfortable. Practitioner Summary: Among neutral, comfortable, maximum, horizontal, and vertical index finger strokes on smartphone rear surfaces, maximum vs. neutral strokes caused 43.8% greater discomfort. Horizontal (vertical) strokes deviated from the horizontal (vertical) axis. Discomfort increased by 12.3% with 90-mm- vs. 60-mm-wide devices. Rear interaction regions of five commercialised smartphones should be lowered 20 to 30 mm for more comfortable rear interaction.

  19. Caspase 3 inactivates biologically active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocation

    International Nuclear Information System (INIS)

    Ali, Shafaqat; Nguyen, Dang Quan; Falk, Werner; Martin, Michael Uwe

    2010-01-01

    IL-33 is a member of the IL-1 family of cytokines with dual function which either activates cells via the IL-33 receptor in a paracrine fashion or translocates to the nucleus to regulate gene transcription in an intracrine manner. We show that full length murine IL-33 is active as a cytokine and that it is not processed by caspase 1 to mature IL-33 but instead cleaved by caspase 3 at aa175 to yield two products which are both unable to bind to the IL-33 receptor. Full length IL-33 and its N-terminal caspase 3 breakdown product, however, translocate to the nucleus. Finally, bioactive IL-33 is not released by cells constitutively or after activation. This suggests that IL-33 is not a classical cytokine but exerts its function in the nucleus of intact cells and only activates others cells via its receptor as an alarm mediator after destruction of the producing cell.

  20. Interaction of the IAEA and the United States in controlling nuclear weapons proliferation

    International Nuclear Information System (INIS)

    Tape, G.F.

    1977-01-01

    The emphasis of this paper is on those aspects of the U. S.-IAEA interactions that pertain to the control and assurance of non-diversion of special nuclear materials. Some background information on the IAEA is given

  1. Interaction of Proliferating Cell Nuclear Antigen With DNA at the Single Molecule Level

    KAUST Repository

    Raducanu, Vlad-Stefan

    2016-01-01

    Proliferating cell nuclear antigen (PCNA) is a key factor involved in Eukaryotic DNA replication and repair, as well as other cellular pathways. Its importance comes mainly from two aspects: the large numbers of interacting partners

  2. Novel nuclear-cytoplasmic interaction in wheat (Triticum aestivum) induces vigorous plants

    Science.gov (United States)

    Interspecific hybridization can be considered an accelerator of evolution, otherwise a slow process, solely dependent on mutation and recombination. Upon interspecific hybridization, several novel interactions between nuclear and cytoplasmic genomes emerge which provide additional sources of diversi...

  3. Antiferromagnetism of nuclear matter in the model with effective Gogny interaction

    International Nuclear Information System (INIS)

    Isayev, A.A.; Yang, J.

    2006-01-01

    The possibility of ferromagnetic (FM) antiferromagnetic (AFM) phase transitions in symmetric nuclear matter is analyzed within the framework of a Fermi-liquid theory with the effective Gogny interaction. It is shown that at some critical density nuclear matter undergoes a phase transition to the AFM spin state. The self-consistent equations of spin-polarized nuclear matter have no solutions corresponding to FM spin ordering and, hence, the FM transition does not appear. The AFM spin state properties are investigated [ru

  4. A dual-route perspective on brain activation in response to visual words: evidence for a length by lexicality interaction in the visual word form area (VWFA).

    Science.gov (United States)

    Schurz, Matthias; Sturm, Denise; Richlan, Fabio; Kronbichler, Martin; Ladurner, Gunther; Wimmer, Heinz

    2010-02-01

    Based on our previous work, we expected the Visual Word Form Area (VWFA) in the left ventral visual pathway to be engaged by both whole-word recognition and by serial sublexical coding of letter strings. To examine this double function, a phonological lexical decision task (i.e., "Does xxx sound like an existing word?") presented short and long letter strings of words, pseudohomophones, and pseudowords (e.g., Taxi, Taksi and Tazi). Main findings were that the length effect for words was limited to occipital regions and absent in the VWFA. In contrast, a marked length effect for pseudowords was found throughout the ventral visual pathway including the VWFA, as well as in regions presumably engaged by visual attention and silent-articulatory processes. The length by lexicality interaction on brain activation corresponds to well-established behavioral findings of a length by lexicality interaction on naming latencies and speaks for the engagement of the VWFA by both lexical and sublexical processes. Copyright (c) 2009 Elsevier Inc. All rights reserved.

  5. Nuclear matter properties using different sets of parameters in the Gogny interaction

    International Nuclear Information System (INIS)

    Ramadan, Kh.A.; Mansour, H.M.M.

    2002-01-01

    In the present work we use the finite range density dependent effective Gogny interaction to study the equation of state of polarized nuclear matter. Six sets of the interaction parameters are used and a comparison is made with the calculations of Friedman and Pandharipande using a realistic interaction. One of the parameter sets (D1) gives similar results for the properties of polarized nuclear matter while the other parameter sets (D1S, D250, D260, D280 and D300) yield results which are reasonably comparable with the realistic interaction calculation of Friedman and Pandharipande. (author)

  6. Bound states and scattering lengths of three two-component particles with zero-range interactions under one-dimensional confinement

    International Nuclear Information System (INIS)

    Kartavtsev, O.I.; Malykh, A.V.; Sofianos, S.A.

    2008-01-01

    The universal three-body dynamics in ultracold binary gases confined to one-dimensional motion is studied. The three-body binding energies and the (2+1)-scattering lengths are calculated for two identical particles of mass m and a different one of mass m 1 , between which interactions are described in the low-energy limit by zero-range potentials. The critical values of the mass ratio m/m 1 , at which the three-body states arise and the (2+1)-scattering length equals zero, are determined both for zero and infinite interaction strength λ 1 of the identical particles. A number of exact results are enlisted and asymptotic dependences both for m/m 1 → infinity and λ 1 → -infinity are derived. Combining the numerical and analytical results, a schematic diagram showing the number of the three-body bound states and the sign of the (2+1)-scattering length in the plane of the mass ratio and interaction-strength ratio is deduced. The results provide a description of the homogeneous and mixed phases of atoms and molecules in dilute binary quantum gases

  7. The role of non-specific interactions in nuclear organization

    NARCIS (Netherlands)

    Nooijer, de S.

    2010-01-01

    The most important organelle in eukaryotic cells is the nucleus. Many processes occurring within the nucleus depend on spatial organization of the nucleus. The spatial organization of the eukaryotic nucleus derives from interactions between its constituents. Both specific interactions, for instance

  8. Heterogeneous nuclear ribonucleoprotein D/AUF1 interacts with ...

    Indian Academy of Sciences (India)

    SEARCHU

    Ribonucleic acids (RNAs) in cells are bound to proteins. Heterogeneous nuclear ribonucleoprotein (hnRNP) is one of the representative proteins bound to RNAs in eukaryotic cells. More than 30 hnRNPs have been determined to exist in human nuclei, and are referred to as hnRNPs A1 through U (Choi and Dreyfuss 1984; ...

  9. [Electroweak and other interactions in medium-energy nuclear physics

    International Nuclear Information System (INIS)

    Mukhopadhyay, N.C.

    1993-01-01

    This report discusses the following topics: spectrum generating algebra; vibrational spectra in the heavy quarkonia; chiral soliton model; pion neutral photoproduction from proton with polarized photons in the delta-1232 region; compton scattering in the delta- 1232 region; nucleon magnetic polarizability and the role of the delta resonance; eta photo- and electroproduction; perturbative QCD; and nuclear muon capture

  10. Nuclear fuel rod with burnable plate and pellet-clad interaction fix

    International Nuclear Information System (INIS)

    Boyle, R.F.

    1987-01-01

    This patent describes a nuclear fuel rod comprising a metallic tubular cladding containing nuclear fuel pellets, the pellets containing enriched uranium-235. The improvement described here comprises: ceramic wafers, each wafter comprising a sintered mixture of gadolinium oxide and uranium dioxide, the uranium oxide having no more uranium-235 than is present in natural uranium dioxide. Each of the wafers is axially disposed between a major portion of adjacent the nuclear fuel pellets, whereby the wafers freeze out volatile fission products produced by the nuclear fuel and prevent interaction of the fission products with the metallic tubing cladding

  11. Jaw1/LRMP has a role in maintaining nuclear shape via interaction with SUN proteins.

    Science.gov (United States)

    Kozono, Takuma; Tadahira, Kazuko; Okumura, Wataru; Itai, Nao; Tamura-Nakano, Miwa; Dohi, Taeko; Tonozuka, Takashi; Nishikawa, Atsushi

    2018-06-06

    Jaw1/LRMP is characterized as a type II integral membrane protein that is localized to endoplasmic reticulum (ER), however, its physiological functions have been poorly understood. An alignment of amino acid sequence of Jaw1 with KASH proteins, outer nuclear membrane proteins, revealed that Jaw1 has a partial homology to the KASH domain. Here, we show that the function of Jaw1 is to maintain nuclear shape in mouse melanoma cell line. The siRNA-mediated knockdown of Jaw1 caused a severe defect in nuclear shape, and the defect was rescued by ectopic expression of siRNA-resistant Jaw1. Since co-immunoprecipitation assay indicates that Jaw1 interacts with SUN proteins that are inner nuclear proteins and microtubules, this study suggests that Jaw1 has a role in maintaining nuclear shape via interactions with SUN proteins and microtubules.

  12. On the systematic behaviour of the intermittency-induces in nuclear interactions

    International Nuclear Information System (INIS)

    Adamovich, M.I.; Aggarwal, M.M.; Alexandrov, Y.A.; Andreeva, N.P.; Anson, Z.V.; Arora, R.; Avetyan, F.A.; Badyal, S.K.; Basova, E.; Bhalla, K.B.; Bhasin, A.; Bhatia, V.S.; Bogdanov, V.G.; Bubnov, V.I.; Burnett, T.H.; Cai, X.; Chasnikov, I.Y.; Chernova, L.P.; Chernyavski, M.M.; Dressel, B.; Eligbaeva, G.Z.; Eremenko, L.E.; Friedlander, E.M.; Gaitinov, A.S.; Ganssauge, E.R.; Garpman, S.; Gerassimov, S.G.; Grote, J.; Gulamov, K.G.; Gupta, S.K.; Gupta, V.; Heckman, H.H.; Huang, H.; Jakobsson, B.; Judek, B.; Kachroo, S.; Kadyrov, F.G.; Kalyachkina, G.S.; Kanygina, E.K.; Karabova, M.; Kaul, G.L.; Kaur, M.; Kharlamov, S.P.; Koss, T.; Krasnov, S.A.; Kumar, V.; Lal, P.; Larionova, V.G.; Lepetan, V.N.; Lindstrom, P.J.; Liu, L.S.; Lokanathan, S.; Lord, J.; Lukicheva, N.S.; Luo, S.B.; Mangotra, L.K.; Marutyan, N.A.; Maslennikova, N.V.; Mittra, I.S.; Mookerjee, S.; Mueller, C.; Nasrulaeva, H.; Nasyrov, S.H.; Navotny, V.S.; Orlova, G.I.; Otterlund, I.; Palsania, H.S.; Peresadko, N.G.; Petrov, N.V.; Plyushchev, V.A.; Qian, W.Y.; Raniwala, R.; Raniwala, S.; Rao, N.K.; Rappoport, V.M.; Rhee, J.T.; Saidkhanov, N.; Salmanova, N.A.; Sarkisova, L.G.; Sarkisyan, V.R.; Schulz, W.; Shabratova, G.S.; Shakhova, T.I.; Singh, B.; Skelding, D.; Soederstroem, K.; Solovjeva, Z.I.; Stenlund, E.; Strausz, S.C.; Sun, J.F.; Svechnikova, L.N.; Tolstov, K.D.; Tretyakova, M.I.; Trofimova, T.P.; Tuleeva, U.; Vokal, S.; Wang, H.Q.; Weng, Z.Q.; Wilkes, R.J.; Xu, G.F.; Zhang, D.H.; Zheng, P.Y.; Zhochova, S.I.; Zhou, D.C.; Zhou, J.C.

    1991-01-01

    The non-statistical fluctuations observed in nuclear interactions, as described by the intermittency-indices from scaled factorial moment analyses, are found to follow a systematic behaviour. The heaviest systems studied, i.e. interactions with sulfur projectiles, are found to have fluctuations which are larger than expected from simple scaling rules. (orig.)

  13. Effects of isospin and momentum dependent interactions on thermal properties of asymmetric nuclear matter

    International Nuclear Information System (INIS)

    Xu Jun; Ma Hongru; Chen Liewen; Li Baoan

    2008-01-01

    Thermal properties of asymmetric nuclear matter are studied within a self-consistent thermal model using an isospin and momentum-dependent interaction (MDI) constrained by the isospin diffusion data in heavy-ion collisions, a momentum-independent interaction (MID), and an isoscalar momentum-dependent interaction (eMDYI). In particular, we study the temperature dependence of the isospin-dependent bulk and single-particle properties, the mechanical and chemical instabilities, and liquid-gas phase transition in hot asymmetric nuclear matter. Our results indicate that the temperature dependence of the equation of state and the symmetry energy are not so sensitive to the momentum dependence of the interaction. The symmetry energy at fixed density is found to generally decrease with temperature and for the MDI interaction the decrement is essentially due to the potential part. It is further shown that only the low momentum part of the single-particle potential and the nucleon effective mass increases significantly with temperature for the momentum-dependent interactions. For the MDI interaction, the low momentum part of the symmetry potential is significantly reduced with increasing temperature. For the mechanical and chemical instabilities as well as the liquid-gas phase transition in hot asymmetric nuclear matter, our results indicate that the boundaries of these instabilities and the phase-coexistence region generally shrink with increasing temperature and are sensitive to the density dependence of the symmetry energy and the isospin and momentum dependence of the nuclear interaction, especially at higher temperatures

  14. On the systematic behaviour of the intermittency-induces in nuclear interactions

    Energy Technology Data Exchange (ETDEWEB)

    Adamovich, M I; Aggarwal, M M; Alexandrov, Y A; Andreeva, N P; Anson, Z V; Arora, R; Avetyan, F A; Badyal, S K; Basova, E; Bhalla, K B; Bhasin, A; Bhatia, V S; Bogdanov, V G; Bubnov, V I; Burnett, T H; Cai, X; Chasnikov, I Y; Chernova, L P; Chernyavski, M M; Dressel, B; Eligbaeva, G Z; Eremenko, L E; Friedlander, E M; Gaitinov, A S; Ganssauge, E R; Garpman, S; Gerassimov, S G; Grote, J; Gulamov, K G; Gupta, S K; Gupta, V; Heckman, H H; Huang, H; Jakobsson, B; Judek, B; Kachroo, S; Kadyrov, F G; Kalyachkina, G S; Kanygina, E K; Karabova, M; Kaul, G L; Kaur, M; Kharlamov, S P; Koss, T; Krasnov, S A; Kumar, V; Lal, P; Larionova, V G; Lepetan, V N; Lindstrom, P J; Liu, L S; Lokanathan, S; Lord, J; Lukicheva, N S; Luo, S B; Mangotra, L K; Marutyan, N A; Maslennikova, N V; Mittra, I S; Mookerjee, S; Mueller, C; Nasrulaeva, H; Nasyrov, S H; Navotny, V S; Orlova, G I; Otterlund, I; Palsania, H S; Peresadko, N G; Petrov, N V; EMU01 Collaboration

    1991-07-18

    The non-statistical fluctuations observed in nuclear interactions, as described by the intermittency-indices from scaled factorial moment analyses, are found to follow a systematic behaviour. The heaviest systems studied, i.e. interactions with sulfur projectiles, are found to have fluctuations which are larger than expected from simple scaling rules. (orig.).

  15. Nuclear interaction potential in a folded-Yukawa model with diffuse densities

    International Nuclear Information System (INIS)

    Randrup, J.

    1975-09-01

    The folded-Yukawa model for the nuclear interaction potential is generalized to diffuse density distributions which are generated by folding a Yukawa function into sharp generating distributions. The effect of a finite density diffuseness or of a finite interaction range is studied. The Proximity Formula corresponding to the generalized model is derived and numerical comparison is made with the exact results. (8 figures)

  16. Calculation of nuclear moment of inertia with proper treatment of pairing interaction

    International Nuclear Information System (INIS)

    Tazaki, S.; Ando, Y.; Hasegawa, M.

    1997-01-01

    An attempt to calculate nuclear moments of inertia treating the pairing interaction exactly is reported. As usual, hamiltonian is composed of the Nilsson's singleparticle energies and the pairing interaction, but the eigenstates and the eigenvalues are calculated exactly in a realistic, sufficiently large model space. The method of calculating the moment of inertia is presented. (author)

  17. Interaction between adrenaline and dibenzo-18-crown-6: Electrochemical, nuclear magnetic resonance, and theoretical study

    Science.gov (United States)

    Yu, Zhang-Yu; Liu, Tao; Wang, Xue-Liang

    2014-12-01

    The interaction between adrenaline (Ad) and dibenzo-18-crown-6 (DB18C6) was studied by cyclic voltammetry, nuclear magnetic resonance spectroscopy, and the theoretical calculations, respectively. The results show that DB18C6 will affect the electron transfer properties of Ad. DB18C6 can form stable supramolecular complexes with Ad through ion-dipole and hydrogen bond interactions.

  18. Search for Screened Interactions Associated with Dark Energy below the 100 μm Length Scale.

    Science.gov (United States)

    Rider, Alexander D; Moore, David C; Blakemore, Charles P; Louis, Maxime; Lu, Marie; Gratta, Giorgio

    2016-09-02

    We present the results of a search for unknown interactions that couple to mass between an optically levitated microsphere and a gold-coated silicon cantilever. The scale and geometry of the apparatus enable a search for new forces that appear at distances below 100  μm and which would have evaded previous searches due to screening mechanisms. The data are consistent with electrostatic backgrounds and place upper limits on the strength of new interactions at 5.6×10^{4} in the region of parameter space where the self-coupling Λ≳5  meV and the microspheres are not fully screened.

  19. Tensor quasiparticle interaction and spin-isospin sound in nuclear matter

    International Nuclear Information System (INIS)

    Haensel, P.

    1979-01-01

    The effect of the tensor components of the quasiparticle interaction in nuclear matter on the spin-isospin sound type excitations is studied. Numerical results are obtained using a simplified model of the quasiparticle interaction in nuclear matter. The quasiparticle distribution matrix corresponding to the spin-isospin sound is found to be qualitatively different from that obtained for purely central quasiparticle interaction. The macroscopic effects, however, are restricted to a small change in the phase velocity of the spin-isospin sound. (Auth.)

  20. Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex

    DEFF Research Database (Denmark)

    Lubas, Michal Szymon; Christensen, Marianne Skovgaard; Kristiansen, Maiken Søndergaard

    2011-01-01

    from nucleoli, and consistently NEXT is specifically required for the exosomal degradation of promoter upstream transcripts (PROMPTs). We also detect putative homolog TRAMP subunits hTRF4-2 (Trf4p) and ZCCHC7 (Air2p) in hRRP6 and hMTR4 precipitates. However, at least ZCCHC7 function is restricted...... to nucleoli. Our results suggest that human nuclear exosome degradation pathways comprise modules of spatially organized cofactors that diverge from the yeast model....

  1. Mito-Nuclear Interactions Affecting Lifespan and Neurodegeneration in a Drosophila Model of Leigh Syndrome.

    Science.gov (United States)

    Loewen, Carin A; Ganetzky, Barry

    2018-04-01

    Proper mitochondrial activity depends upon proteins encoded by genes in the nuclear and mitochondrial genomes that must interact functionally and physically in a precisely coordinated manner. Consequently, mito-nuclear allelic interactions are thought to be of crucial importance on an evolutionary scale, as well as for manifestation of essential biological phenotypes, including those directly relevant to human disease. Nonetheless, detailed molecular understanding of mito-nuclear interactions is still lacking, and definitive examples of such interactions in vivo are sparse. Here we describe the characterization of a mutation in Drosophila ND23 , a nuclear gene encoding a highly conserved subunit of mitochondrial complex 1. This characterization led to the discovery of a mito-nuclear interaction that affects the ND23 mutant phenotype. ND23 mutants exhibit reduced lifespan, neurodegeneration, abnormal mitochondrial morphology, and decreased ATP levels. These phenotypes are similar to those observed in patients with Leigh syndrome, which is caused by mutations in a number of nuclear genes that encode mitochondrial proteins, including the human ortholog of ND23 A key feature of Leigh syndrome, and other mitochondrial disorders, is unexpected and unexplained phenotypic variability. We discovered that the phenotypic severity of ND23 mutations varies depending on the maternally inherited mitochondrial background. Sequence analysis of the relevant mitochondrial genomes identified several variants that are likely candidates for the phenotypic interaction with mutant ND23 , including a variant affecting a mitochondrially encoded component of complex I. Thus, our work provides an in vivo demonstration of the phenotypic importance of mito-nuclear interactions in the context of mitochondrial disease. Copyright © 2018 by the Genetics Society of America.

  2. FTZ-Factor1 and Fushi tarazu interact via conserved nuclear receptor and coactivator motifs

    Science.gov (United States)

    Schwartz, Carol J.E.; Sampson, Heidi M.; Hlousek, Daniela; Percival-Smith, Anthony; Copeland, John W.R.; Simmonds, Andrew J.; Krause, Henry M.

    2001-01-01

    To activate transcription, most nuclear receptor proteins require coactivators that bind to their ligand-binding domains (LBDs). The Drosophila FTZ-Factor1 (FTZ-F1) protein is a conserved member of the nuclear receptor superfamily, but was previously thought to lack an AF2 motif, a motif that is required for ligand and coactivator binding. Here we show that FTZ-F1 does have an AF2 motif and that it is required to bind a coactivator, the homeodomain-containing protein Fushi tarazu (FTZ). We also show that FTZ contains an AF2-interacting nuclear receptor box, the first to be found in a homeodomain protein. Both interaction motifs are shown to be necessary for physical interactions in vitro and for functional interactions in developing embryos. These unexpected findings have important implications for the conserved homologs of the two proteins. PMID:11157757

  3. Lunar and Martian environmental interactions with nuclear power system radiators

    International Nuclear Information System (INIS)

    Perez-Davis, M.E.; Gaier, J.R.; Katzan, C.M.

    1994-01-01

    In the foreseeable future, NASA space milestones include a permanent manned presence on the Moon and an expedition to the planet Mars. Such steps will require careful consideration of environmental interactions in the selection and design of required power systems. Several environmental constituents may be hazardous to performance integrity. Potential threats common to both the Moon and Mars are low ambient temperatures, wide daily temperature swings, solar flux, and large quantities of dust. The surface of Mars provides the additional challenges of dust storms, winds, and a carbon dioxide atmosphere. In this review, the anticipated environmental interactions with surface power system radiators are described, as well as the impacts of these interactions on radiator durability, which have been identified at NASA Lewis Research Center

  4. The proton-neutron interaction and nuclear collectivity

    International Nuclear Information System (INIS)

    Casten, R.F.

    1987-01-01

    A review is given of several aspects, and empirical consequences, of the p-n interaction as it relates to the structure, phase transitions and collectivity of medium and heavy nuclei. The N/sub p/N/sub n/ scheme is reviewed as background material while the emphasis centers on a discussion of a related quantity, the P factor, and on the relationship of the integrated strength of the p-n interaction to the empirically observed ''saturation'' of B(E2) values in the mid-shell regions of deformed nuclei. 19 refs., 13 figs

  5. Azimuthal asymmetry of slow particles in high energy nuclear interaction

    International Nuclear Information System (INIS)

    Sarkar, Subir; Goswami, T.D.

    2002-01-01

    An asymmetry in the angular distribution of slow particles in the azimuthal plane has been observed during high energy nuclear disintegration of photo emulsion nuclei exposed to 1.8 GeV/c k - and 20 GeV/c protons. The mechanism of disintegration is not in accordance with the cascade-evaporation model, which is based on isotropic emission of slow particles. Deviation from isotropy indicates that some of the slow particles might be emitted well before the thermal equilibrium is reached in the disintegrating system. (author)

  6. DNA-nuclear matrix interactions and ionizing radiation sensitivity

    International Nuclear Information System (INIS)

    Schwartz, J.L.; Vaughan, A.T.M.

    1993-01-01

    The association between inherent ionizing radiation sensitivity and DNA supercoil unwinding in mammalian cells suggests that the organization of the DNA in chromosomes plays an important role in radiation responses. In this paper, a model is proposed which suggests that these DNA unwinding alterations reflect differences in the attachment of DNA to the nuclear matrix. In radioresistant cells, the MAR structure might exist in a more stable, open configuration, limiting DNA unwinding following strand break induction and influencing the rate and nature of DNA double-strand break rejoining

  7. DNA-nuclear matrix interactions and ionizing radiation sensitivity

    International Nuclear Information System (INIS)

    Schwartz, J.L.; Chicago Univ., IL; Vaughan, A.T.M.

    1993-01-01

    The association between inherent ionizing radiation sensitivity and DNA supercoil unwinding in mammalian cells suggests that the DNA-nuclear matrix attachment region (MAR) plays an important role in radiation response. In radioresistant cells, the MAR structure may exist in a more stable, open configuration, limiting DNA unwinding following strand break induction and maintaining DNA ends in close proximity for more rapid and accurate rejoining. In addition, the open configuration at these matrix attachment sites may serve to facilitate rapid DNA processing of breaks by providing (1) sites for repair proteins to collect and (2) energy to drive enzymatic reactions

  8. Mean multiplicity of secondary particles in hadron-nuclear interactions

    International Nuclear Information System (INIS)

    Alaverdyan, G.B.; Pak, A.S.

    1980-01-01

    The mean multiplicity of secondary particles in hA interactions is examined in the framework of the multiplex scattering theory. The dependence of the secondary particle multiplicity coefficient Rsub(6)=anti nsub(hA)/anti nsub(hN) (where anti nsub(hA) and anti nsub(hN) are mean multiplicities of secondary relativistic particles in hA and hN interactions, respectively) on the energy and type of incident particles and atomic number of a target nucleus is analysed. It is shown that predictions of the leading particle cascade model are in satisfactory agreement with the experimental data if the uncertainties of the inelasticity in hN interactions are taken into account. The value Rsub(A) weakly depends both on the incident particle energy and the form of parametrization anti nsub(hN)(E). Allowance of energy losses fluctuation of leading particle results in the Rsub(A) value decrease. From the model of leading particles it does not follow that Rsub(a) strictly depends on the type of incident particles at the fixed value of mean number of collisions. But quantitative values of Rsub(A) for different types of particles and at one value of anti ν, (i.e. at properly chosen value) coincide. The value of Rsub(A) is profoundly dependent on the values of inelasticity factor in hN interactions

  9. Heat shock-induced interactions among nuclear HSFs detected by fluorescence cross-correlation spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Pack, Chan-Gi, E-mail: changipack@amc.seoul.kr [Asan Institute for Life Sciences, University of Ulsan, College of Medicine, Asan Medical Center, Seoul 138-736 (Korea, Republic of); Ahn, Sang-Gun [Dept. of Pathology, College of Dentistry, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759 (Korea, Republic of)

    2015-07-31

    The cellular response to stress is primarily controlled in cells via transcriptional activation by heat shock factor 1 (HSF1). HSF1 is well-known to form homotrimers for activation upon heat shock and subsequently bind to target DNAs, such as heat-shock elements, by forming stress granules. A previous study demonstrated that nuclear HSF1 and HSF2 molecules in live cells interacted with target DNAs on the stress granules. However, the process underlying the binding interactions of HSF family in cells upon heat shock remains unclear. This study demonstrate for the first time that the interaction kinetics among nuclear HSF1, HSF2, and HSF4 upon heat shock can be detected directly in live cells using dual color fluorescence cross-correlation spectroscopy (FCCS). FCCS analyses indicated that the binding between HSFs was dramatically changed by heat shock. Interestingly, the recovery kinetics of interaction between HSF1 molecules after heat shock could be represented by changes in the relative interaction amplitude and mobility. - Highlights: • The binding interactions among nuclear HSFs were successfully detected. • The binding kinetics between HSF1s during recovery was quantified. • HSF2 and HSF4 strongly formed hetero-complex, even before heat shock. • Nuclear HSF2 and HSF4 bound to HSF1 only after heat shock.

  10. Investigation of interaction between alkoxy substituted phthalocyanines with different lengths of alkyl residue and bovine serum albumin

    Energy Technology Data Exchange (ETDEWEB)

    Lebedeva, Natalya Sh., E-mail: nsl@isc-ras.ru [G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, Akademicheskaya, 1, 153045 Ivanovo (Russian Federation); Gubarev, Yury A.; Vyugin, Anatoly I. [G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, Akademicheskaya, 1, 153045 Ivanovo (Russian Federation); Koifman, Oscar I. [Research Institute of Macroheterocycles of Ivanovo State University of Chemistry and Technology, 153000 Ivanovo (Russian Federation)

    2015-10-15

    Interaction between bovine serum albumin and alkoxy substituted phthalocyanines was studied by means of electron absorption spectroscopy, fluorescence spectroscopy and viscosimetry. The binding constants and binding distance were calculated. It was found that ZnPc(4-NH-CO-C{sub 6}H{sub 4}-OC{sub 10}H{sub 21}){sub 4} prevents twisting of BSA molecule and localizes between subdomains IB and IIA in protein globule. ZnPc(4-NH-CO-C{sub 6}H{sub 4}-OC{sub 6}H{sub 13}){sub 4} and ZnPc(4-NH-CO-C{sub 6}H{sub 4}-OC{sub 8}H{sub 17}){sub 4} are located on the outer surface of the protein globule. In the case of ZnPc(4-NH-CO-C{sub 6}H{sub 4}-OC{sub 3}H{sub 7}){sub 4} it can be assumed that the phthalocyanine molecule is in the immediate vicinity of the subdomains IB and IIA. - Highlights: • Interaction between bovine serum albumin and alkoxy substituted phthalocyanines was studied by means of electron absorption spectroscopy, fluorescence spectroscopy and viscosimetry. • The binding constants and binding distance were calculated by using the Scatchard method. • Photochemical characteristics of phthalocyanines of studied phthalocyanines are defined. • Localization of phthalocyanines on the protein globule is defined.

  11. Fanconi Anemia Proteins FANCA, FANCC, and FANCG/XRCC9 Interact in a Functional Nuclear Complex

    OpenAIRE

    Garcia-Higuera, Irene; Kuang, Yanan; Näf, Dieter; Wasik, Jennifer; D’Andrea, Alan D.

    1999-01-01

    Fanconi anemia (FA) is an autosomal recessive cancer susceptibility syndrome with at least eight complementation groups (A to H). Three FA genes, corresponding to complementation groups A, C, and G, have been cloned, but their cellular function remains unknown. We have previously demonstrated that the FANCA and FANCC proteins interact and form a nuclear complex in normal cells, suggesting that the proteins cooperate in a nuclear function. In this report, we demonstrate that the recently clone...

  12. Shocks from high-energy nuclear-interacting particles in the mountain Chakaltajya

    Energy Technology Data Exchange (ETDEWEB)

    Kamata, K [Tokyo Univ. (Japan)

    1975-06-01

    Experimental investigations of extensive air showers at the height of 5200 m above the sea level have been performed. The behaviour of high energy nuclear active particles in the cores of the showers has been studied using the nuclear knock-on method. The cross section of the proton inelastic interaction with the air is shown to increase with energy in the energy range of 3-9 TeV.

  13. Modeling nuclear weak-interaction processes with relativistic energy density functionals

    International Nuclear Information System (INIS)

    Paar, N.; Marketin, T.; Vale, D.; Vretenar, D.

    2015-01-01

    Relativistic energy density functionals have become a standard framework for nuclear structure studies of ground state properties and collective excitations over the entire nuclide chart. In this paper, we review recent developments in modeling nuclear weak-interaction processes: Charge-exchange excitations and the role of isoscalar proton–neutron pairing, charged-current neutrino–nucleus reactions relevant for supernova evolution and neutrino detectors and calculation of β-decay rates for r-process nucleosynthesis. (author)

  14. Man-machine interaction in Canadian nuclear power plants

    International Nuclear Information System (INIS)

    Olmstead, R.A.

    1994-01-01

    The design of man-machine interaction in the CANDU plants has evolved considerably over several generations of plants, from the first Douglas Point plant through to the next generation of plants represented by new designs like CANDU 3. In the early plants, the control room configuration was based on designers' projections of control interface requirements. With succeeding generations of designs, there has been an evolution towards a more systematic consideration of human strengths and weaknesses, increasing attention to formal requirements definition, and incorporation of a larger base of operational experience. This paper describes the design of the man-machine interaction for third generation CANDU-3 control rooms for improved operator reliability and reduced costs. (author). 13 refs., 3 figs

  15. Reduction of nuclear moment of inertia due to pairing interaction

    International Nuclear Information System (INIS)

    Zeng, J.Y.; Jin, T.H.; Zhao, Z.J.

    1994-01-01

    The BCS theoretical values of the moments of inertia of even-even nuclei are systematically smaller than the experimental ones by a factor of 10--40%. This long-standing discrepancy disappears in the particle-number-conserving treatment for the cranked shell model, in which the blocking effects are taken into account exactly. The calculated moments of inertia satisfactorily reproduce the experimental data covering a large number of rare-earth even-even nuclei, whose deformations and single-particle states are well characterized (Lund systematics). The pairing interaction strength G is unambiguously determined by the even-odd mass difference. The reduction of the moment of inertia due to the antialignment effect of pairing interaction is discussed and no systematic excessive reduction is found

  16. Binding energies of hypernuclei and Λ-nuclear interactions

    International Nuclear Information System (INIS)

    Bodmer, A.R.; Usmani, Q.N.

    1984-01-01

    Variational calculations indicate that a reasonable description of Λp scattering and of Λ separation energies can be obtained in terms of ΛN plus dispersive and TPE ΛNN forces. Results for the ΛΛ interaction and for 6 /sub Λ/He obtained from an analysis of 10 /sub ΛΛ/Be are discussed. Coulomb and ΛN charge symmetry breaking effects in the A = 4 hypernuclei are discussed

  17. Nuclear structure calculations in the dynamic-interaction propagator approach

    International Nuclear Information System (INIS)

    Engelbrecht, C.A.; Hahne, F.J.W.; Heiss, W.D.

    1978-01-01

    The dynamic-interaction propagator approach provides a natural method for the handling of energy-dependent effective two-body interactions induced by collective excitations of a many-body system. In this work this technique is applied to the calculation of energy spectra and two-particle strengths in mass-18 nuclei. The energy dependence is induced by the dynamic exchange of the lowest 3 - octupole phonon in O 16 , which is described within a normal static particle-hole RPA. This leads to poles in the two-body self-energy, which can be calculated if other fermion lines are restricted to particle states. The two-body interaction parameters are chosen to provide the correct phonon energy and reasonable negative-parity mass-17 and positive-parity mass-18 spectra. The fermion lines must be dressed consistently with the same exchange phonon to avoid redundant solutions or ghosts. The negative-parity states are then calculated in a parameter-free way which gives good agreement with the observed spectra [af

  18. Fundamental length and relativistic length

    International Nuclear Information System (INIS)

    Strel'tsov, V.N.

    1988-01-01

    It si noted that the introduction of fundamental length contradicts the conventional representations concerning the contraction of the longitudinal size of fast-moving objects. The use of the concept of relativistic length and the following ''elongation formula'' permits one to solve this problem

  19. Interactions of rat repetitive sequence MspI8 with nuclear matrix proteins during spermatogenesis

    International Nuclear Information System (INIS)

    Rogolinski, J.; Widlak, P.; Rzeszowska-Wolny, J.

    1996-01-01

    Using the Southwestern blot analysis we have studied the interactions between rat repetitive sequence MspI8 and the nuclear matrix proteins of rats testis cells. Starting from 2 weeks the young to adult animal showed differences in type of testis nuclear matrix proteins recognizing the MspI8 sequence. The same sets of nuclear matrix proteins were detected in some enriched in spermatocytes and spermatids and obtained after fractionation of cells of adult animal by the velocity sedimentation technique. (author). 21 refs, 5 figs

  20. The electron-spin--nuclear-spin interaction studied by polarized neutron scattering.

    Science.gov (United States)

    Stuhrmann, Heinrich B

    2007-11-01

    Dynamic nuclear spin polarization (DNP) is mediated by the dipolar interaction of paramagnetic centres with nuclear spins. This process is most likely to occur near paramagnetic centres at an angle close to 45 degrees with respect to the direction of the external magnetic field. The resulting distribution of polarized nuclear spins leads to an anisotropy of the polarized neutron scattering pattern, even with randomly oriented radical molecules. The corresponding cross section of polarized coherent neutron scattering in terms of a multipole expansion is derived for radical molecules in solution. An application using data of time-resolved polarized neutron scattering from an organic chromium(V) molecule is tested.

  1. Flame Length

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Flame length was modeled using FlamMap, an interagency fire behavior mapping and analysis program that computes potential fire behavior characteristics. The tool...

  2. Nuclear effect study on nucleon structure functions, in comparison with antineutrino interactions on neon and deuterium

    International Nuclear Information System (INIS)

    Vallee, C.

    1984-03-01

    We have studied the nuclear effects on high energy antineutrino charged current interactions by comparing the data which were taken in the Bubble Chamber BEBC filled with Neon and Deuterium. On the one hand, the study of nuclear reinteractions gave us the possibility to estimate the formation time of hadrons. On the other hand, the comparison of structure functions does not show any significant difference between Neon and Deuterium. Though this result does not contradict the effects observed with charged leptons by the EMC and SLAC experiments, it is strongly incompatible with certain theoretical interpretations which implied a stronger effect in antineutrino interactions [fr

  3. Rapid, portable detection of endocrine disrupting chemicals through ligand-nuclear hormone receptor interactions.

    Science.gov (United States)

    Hunt, J Porter; Schinn, Song-Min; Jones, Matthew D; Bundy, Bradley C

    2017-12-04

    Endocrine disrupting chemicals (EDC) are structurally diverse compounds that can interact with nuclear hormone receptors, posing significant risk to human and ecological health. Unfortunately, many conventional biosensors have been too structure-specific, labor-intensive or laboratory-oriented to detect broad ranges of EDC effectively. Recently, several technological advances are providing more rapid, portable, and affordable detection of endocrine-disrupting activity through ligand-nuclear hormone receptor interactions. Here, we overview these recent advances applied to EDC biosensors - including cell lyophilization, cell immobilization, cell-free systems, smartphone-based signal detection, and improved competitive binding assays.

  4. RanBP3 influences interactions between CRM1 and its nuclear protein export substrates

    OpenAIRE

    Englmeier, Ludwig; Fornerod, Maarten; Bischoff, F. Ralf; Petosa, Carlo; Mattaj, Iain W.; Kutay, Ulrike

    2001-01-01

    We investigated the role of RanBP3, a nuclear member of the Ran-binding protein 1 family, in CRM1-mediated protein export in higher eukaryotes. RanBP3 interacts directly with CRM1 and also forms a trimeric complex with CRM1 and RanGTP. However, RanBP3 does not bind to CRM1 like an export substrate. Instead, it can stabilize CRM1–export substrate interaction. Nuclear RanBP3 stimulates CRM1-dependent protein export in permeabilized cells. These data indicate that RanBP3 functions by a novel mec...

  5. Two pion mediated scalar isoscalar NN interaction in the nuclear medium

    International Nuclear Information System (INIS)

    Kaskulov, Murat M.; Oset, E.; Vacas, M.J. Vicente

    2006-01-01

    We study the modification of the nucleon-nucleon interaction in a nuclear medium in the scalar isoscalar channel, mediated by the exchange of two correlated (σ channel) or uncorrelated pions. For this purpose we use a standard approach for the renormalization of pions in nuclei. The corrections obtained for the NN interaction in the medium in this channel are of the order of 20% of the free one in average, and the consideration of short-range correlations plays an important role in providing these moderate changes. Yet, the corrections are sizable enough to suggest further studies of the stability and properties of nuclear matter

  6. Nuclear deformation in the configuration-interaction shell model

    Science.gov (United States)

    Alhassid, Y.; Bertsch, G. F.; Gilbreth, C. N.; Mustonen, M. T.

    2018-02-01

    We review a method that we recently introduced to calculate the finite-temperature distribution of the axial quadrupole operator in the laboratory frame using the auxiliary-field Monte Carlo technique in the framework of the configuration-interaction shell model. We also discuss recent work to determine the probability distribution of the quadrupole shape tensor as a function of intrinsic deformation β,γ by expanding its logarithm in quadrupole invariants. We demonstrate our method for an isotope chain of samarium nuclei whose ground states describe a crossover from spherical to deformed shapes.

  7. Searches for T-odd interactions in nuclear processes: Review of the theory

    International Nuclear Information System (INIS)

    Herczeg, P.

    1995-01-01

    CP-violation has been seen so far only in the neutral kaon system. Its origin is still unknown. If the CPT theorem holds, as is the case in gauge theories, CP-violating interactions violate also time reversal (T) invariance. Regarding the CPT theorem there is some experimental evidence that the interaction responsible for the observed CP-violation violates T-invariance. The observed CP-violation may just be a manifestation of the weak interaction of the Standard Model (SM), or it is due to an interaction beyond the SM. In both cases some of the new interactions may give rise to observable CP-violation where the SM contribution is invisible. This underlines the importance of searching for CP-violating and T-violating effects in many processes. In this talk we shall review what has been learned about T-violating interactions that can be probed in nuclear processes from experiments outside of and within nuclear physics, and consider the role of nuclear physics experiments in obtaining further information on such interactions

  8. Estimation of nuclear destruction in high energy nucleus-nucleus interactions

    International Nuclear Information System (INIS)

    Uzhinskij, V.V.

    1995-01-01

    It is assumed that: 1) a projectile particle invokes into target nucleus a cascade of quark-gluon exchanges; 2) the nucleons involved in the cascade are ejected from the nucleus which leads to the nuclear destruction. On these bases a simple model to estimate the nuclear destruction at the fast stage of the interaction is proposed. The allowed region of the model parameters is determined at the proton-emulsion high-energy interaction data analysis: an analysis of gold interactions with nuclei at an energy of 600 MeV/nucleon fixes the parameter values. The distributions on the energy in zero degree calorimeter (T ZDC ) in the interactions of Si+Al, Cu, Pb (14 GeV/nucleon) and Au+Au (10 GeV/nucleon) calculated in the framework of the model and in the cascade-evaporation model (CEM) are presented. The proposed model describes the nuclear destruction at intermediate and high energies better than CEM does. The estimation of the average values of impact parameter and the number of intra-nuclear collisions for Au+Au interactions in the events with different T ZDC is given. 34 refs., 11 figs

  9. Nuclear thermal rocket plume interactions with spacecraft. Final report

    International Nuclear Information System (INIS)

    Mauk, B.H.; Gatsonis, N.A.; Buzby, J.; Yin, X.

    1997-01-01

    This is the first study that has treated the Nuclear Thermal Rocket (NTR) effluent problem in its entirety, beginning with the reactor core, through the nozzle flow, to the plume backflow. The summary of major accomplishments is given below: (1) Determined the NTR effluents that include neutral, ionized and radioactive species, under typical NTR chamber conditions. Applied an NTR chamber chemistry model that includes conditions and used nozzle geometries and chamber conditions typical of NTR configurations. (2) Performed NTR nozzle flow simulations using a Navier-Stokes solver. We assumed frozen chemistry at the chamber conditions and used nozzle geometries and chamber conditions typical of NTR configurations. (3) Performed plume simulations using a Direct Simulation Monte Carlo (DSMC) code with chemistry. In order to account for radioactive trace species that may be important for contamination purposes we developed a multi-weighted DSMC methodology. The domain in our simulations included large regions downstream and upstream of the exit. Inputs were taken from the Navier-Stokes solutions

  10. Semihard interactions in nuclear collisions based on a unified approach to high energy scattering

    International Nuclear Information System (INIS)

    Drescher, H.J.; Hladik, M.; Werner, K.; Ostapchenko, S.; Centre National de la Recherche Scientifique, 44 - Nantes

    1998-01-01

    Our ultimate goal is the construction of a model for interactions of two nuclei in the energy range between several tens of GeV up to several TeV per nucleon in the centre-of-mass system. Such nuclear collisions are very complex, being composed of many components, and therefore some strategy is needed to construct a reliable model. The central point of our approach is the hypothesis, that the behavior of high energy interactions is universal (universality hypothesis). A model for nuclear interactions in a modular fashion is proposed. The individual modules, based on the universality hypothesis, are identified as building blocks for more elementary interactions (like e + e - , lepton-proton), and can therefore be studied in a much simpler context. With these building blocks under control, a quite reliable model is developed for nucleus-nucleus scattering, providing in particular very useful tests for the complicated numerical procedures using Monte Carlo techniques. (author)

  11. Binding energies of hypernuclei and Λ-nuclear interactions

    International Nuclear Information System (INIS)

    Bodmer, A.R.; Usmani, Q.N.

    1985-01-01

    Variational Monte Carlo calculations have been made for the s-shell hypernuclei and also of 9 Be hypernuclei with a 2α + Λ model. The well depth is calculated variationally with the Fermi hypernetted chain method. A satisfactory description of all the relevant experimental Λ separation energies and also of the Λp scattering can be obtained with reasonable TPE ΛN and ΛNN forces and strongly repulsive dispersive ΛNN forces which are preferred to be spin dependent. We discuss variational calculations for 6 He and 10 Be hypernuclei with α + 2Λ and 2α + 2Λ models, and the results obtained for the ΛΛ interaction and for 6 He hypernuclei from analysis of 10 Be hypernuclei Coulomb effects and charge symmetry breaking in the A = 4 hypernuclei are discussed. 24 refs., 5 figs

  12. Binding energies of hypernuclei and. lambda. -nuclear interactions

    Energy Technology Data Exchange (ETDEWEB)

    Bodmer, A.R.; Usmani, Q.N.

    1985-01-01

    Variational Monte Carlo calculations have been made for the s-shell hypernuclei and also of /sup 9/Be hypernuclei with a 2..cap alpha.. + ..lambda.. model. The well depth is calculated variationally with the Fermi hypernetted chain method. A satisfactory description of all the relevant experimental ..lambda.. separation energies and also of the ..lambda..p scattering can be obtained with reasonable TPE ..lambda..N and ..lambda..NN forces and strongly repulsive dispersive ..lambda..NN forces which are preferred to be spin dependent. We discuss variational calculations for /sup 6/He and /sup 10/Be hypernuclei with ..cap alpha.. + 2..lambda.. and 2..cap alpha.. + 2..lambda.. models, and the results obtained for the ..lambda lambda.. interaction and for /sup 6/He hypernuclei from analysis of /sup 10/Be hypernuclei Coulomb effects and charge symmetry breaking in the A = 4 hypernuclei are discussed. 24 refs., 5 figs.

  13. Nuclear weak interactions, supernova nucleosynthesis and neutrino oscillation

    Science.gov (United States)

    Kajino, Toshitaka

    2013-07-01

    We study the nuclear weak response in light-to-heavy mass nuclei and calculate neutrino-nucleus cross sections. We apply these cross sections to the explosive nucleosynthesis in core-collapse supernovae and find that several isotopes of rare elements 7Li, 11B, 138La, 180Ta and several others are predominantly produced by the neutrino-process nucleosynthesis. We discuss how to determine the suitable neutrino spectra of three different flavors and their anti-particles in order to explain the observed solar system abundances of these isotopes, combined with Galactic chemical evolution of the light nuclei and the heavy r-process elements. Light-mass nuclei like 7Li and 11B, which are produced in outer He-layer, are strongly affected by the neutrino flavor oscillation due to the MSW (Mikheyev-Smirnov-Wolfenstein) effect, while heavy-mass nuclei like 138La, 180Ta and r-process elements, which are produced in the inner O-Ne-Mg layer or the atmosphere of proto-neutron star, are likely to be free from the MSW effect. Using such a different nature of the neutrino-process nucleosynthesis, we study the neutrino oscillation effects on their abundances, and propose a new novel method to determine the unknown neutrino oscillation parameters, θ13 and mass hierarchy, simultaneously. There is recent evidence that some SiC X grains from the Murchison meteorite may contain supernova-produced neutrino-process 11B and 7Li encapsulated in the grains. Combining the recent experimental constraints on θ13, we show that although the uncertainties are still large, our method hints at a marginal preference for an inverted neutrino mass hierarchy for the first time.

  14. Automated system for processing nuclear emulsion data on nuclear-nuclear interactions for EMU-15 CERN experiment

    International Nuclear Information System (INIS)

    Aleksandrov, A.B.; Azarenkova, I.Yu.; Feinberg, E.L.; Goneharova, L.A.; Martynov, A.G.; Polukhina, N.G.; Starkov, N.I.

    2004-01-01

    The EMU-15 experiment has been performed at CERN by the LPI group with the aim of studying characteristics of high-density and high-temperature nuclear matter, in particular, for searching for manifestation of quark-gluon plasma. The main problem inherent in these investigations is a large amount of track measurements in nuclear emulsions. A very efficient Completely Automated Measuring Complex (Russian abbreviation sounds as P AVICOM ) for track-detector data processing in nuclear and high-energy particle physics is operating at the Lebedev Physical Institute. The PAVICOM provides essential improving the efficiency of experimental studies performed not only by the LPI group, but also by many Russian Institutes

  15. Nuclear structure with unitarily transformed two-body plus phenomenological three-body interactions

    Energy Technology Data Exchange (ETDEWEB)

    Guenther, Anneke

    2011-02-02

    The importance of three-nucleon forces for a variety of nuclear structure phenomena is apparent in various investigations. This thesis provides a first step towards the inclusion of realistic three-nucleon forces by studying simple phenomenological threebody interactions. The Unitary Correlation Operator Method (UCOM) and the Similarity Renormalization Group (SRG) provide two different approaches to derive soft phase-shift equivalent nucleon-nucleon (NN) interactions via unitary transformations. Although their motivations are quite different the NN interactions obtained with the two methods exhibit some similarities. The application of the UCOM- or SRG-transformed Argonne V18 potential in the Hartree-Fock (HF) approximation and including the second-order energy corrections emerging from many-body perturbation theory (MBPT) reveals that the systematics of experimental ground-state energies can be reproduced by some of the interactions considering a series of closed-shell nuclei across the whole nuclear chart. However, charge radii are systematically underestimated, especially for intermediate and heavy nuclei. This discrepancy to experimental data is expected to result from neglected three-nucleon interactions. As first ansatz for a three-nucleon force, we consider a finite-range three-body interaction of Gaussian shape. Its influence on ground-state energies and charge radii is discussed in detail on the basis of HF plus MBPT calculations and shows a significant improvement in the description of experimental data. As the handling of the Gaussian three-body interaction is time-extensive, we show that it can be replaced by a regularized three-body contact interaction exhibiting a very similar behavior. An extensive study characterizes its properties in detail and confirms the improvements with respect to nuclear properties. To take into account information of an exact numerical solution of the nuclear eigenvalue problem, the No-Core Shell Model is applied to

  16. A sensitivity study of seismic structure-soil-structure interaction problems for nuclear power plants

    International Nuclear Information System (INIS)

    Matthees, W.; Magiera, G.

    1982-01-01

    A sensitivity study for the interaction effects of adjacent structures of nuclear power plants caused by horizontal seismic excitation has been performed. The key structural and soil parameters for linear and for nonlinear behaviour were varied within their applicable bandwidth. It has been shown that the interaction phenomena can contribute to the response of structures to such a large extent that it cannot be disregarded. (orig.)

  17. Interactive and automated systems for nuclear track measurements with applications to fast neutron dosimetry

    International Nuclear Information System (INIS)

    Roberts, J.H.; Gold, R.; McNeece, J.P.; Preston, C.C.; Ruddy, F.H.

    1983-12-01

    Interactive and automatic track measuring systems have been developed primarily for fast neutron dosimetry in and around reactors. The interactive system is used for proton recoil measurements in nuclear research emulsions and the automatic systems for counting fission fragment tracks in Muscovite mica. The status of these systems, along with illustrative applications, are presented, particularly with regard to their relationship to neutron personnel dosimetry. 16 references, 12 figures

  18. Nuclear quadrupole-quadrupole interaction in the inelastic scattering of aligned deuterons from deformed nuclei

    International Nuclear Information System (INIS)

    Clement, H.; Frick, R.; Graw, G.; Schiemenz, P.; Seichert, N.

    1983-01-01

    The 2 1 + -excitation of deformed nuclei by tensor polarized deuterons provides an alignment of both nuclei and thus a means to study specifically the quadrupole-quadrupole interaction between both nuclei. The tensor analyzing power Asub(xz)(theta) has been measured for the elastic and inelastic scattering on 24 Mg and 28 Si. The coupled channel analysis including a deformed tensor potential reveals a clear signature of the quadrupole-quadrupole part of the nuclear projectile-target interaction. (orig.)

  19. Experiments on the nuclear interactions of pions and electrons

    International Nuclear Information System (INIS)

    Minehart, R.C.; Ziock, K.O.H.

    1989-07-01

    We have completed the analysis of the 3 He(π + ,pp)n reaction, and are working on the analysis of data for the 3 He(π - ,pn)p reaction. An experiment to study the π + d → 2p reaction at LAMPF was successful in studying incident pion energies as low as 6 MeV. Preliminary results have been reported, and work is continuing to improve the accuracy in the calculation of the fraction of pions in the incident beam. A proposal has been accepted by LAMPF for a new experiment, scheduled to run in the summer of 1990, to study pion absorption in 3 He and 4 He using an extensive scintillator time-of-flight system capable of detecting neutrons as well as charged particles. We are continuing to analyze data obtained in PSI in the search for the admixture of massive neutrinos in pion decay and have continued the search for fractionally charged particles. We are also fully involved in some major collaborations: the search for the decay μ + → e + + γ, and the study of anti-proton absorption in heavy nuclei. We are taking part in a U.Va.-PSI collaboration to measure pion beta decay to an accuracy of about 1%, using a large acceptance CsI detector to measure the π 0 following decay of stopped π + mesons. We have also been working on experiments to study electron scattering, using the SLAC-NPAS facility for nuclear physics and the electron accelerator at SACLAY in France. Data from experiment NE-9 at SLAC are being analyzed. This experiment, which was run near the end of 1987, is intended to separate the transverse and longitudinal cross sections for inclusive electron scattering in the QFS region. Experiment NE-8 measured the cross section for photo-disintegration of the deuteron in the GeV range. Some design work was carried out this year on Experiment NE-16 at SLAC, a study of the (e,e'p) reaction in 4 He, expected to run late in 1990

  20. Interactions between nuclear polyhedrosis virus and Nosema sp. infecting gypsy moth

    Science.gov (United States)

    L. S. Bauer; M. McManus; J. Maddox

    1991-01-01

    Nuclear polyhedrosis virus (NPV) is the only entomopathogen that plays an important role in the natural regulation of North American gypsy moth populations. Recent European studies suggest that populations of gypsy moth in Eurasia are regulated primarily by the interactions between NPV and several species of microsporidia. Researchers have proposed that the...

  1. Nuclear interaction contribution to SEUs in heavy ion energy deposition in the ESA monitor

    CERN Document Server

    Bahamonde, Cristina

    2013-01-01

    The effects of nuclear interactions inducing Single Event Upsets in ESA SEU monitor are explored for heavy ion beams of different energies. The experimental and simulated results are compared, the possible causes of disagreement are suggested as well as the future steps to take.

  2. The Insulator Protein SU(HW) Fine-Tunes Nuclear Lamina Interactions of the Drosophila Genome

    NARCIS (Netherlands)

    Van Bemmel, J.G.; Pagie, L.; Braunschweig, U.; Brugman, W.; Meuleman, W.; Kerkhoven, R.M.; Van Steensel, B.

    2010-01-01

    Specific interactions of the genome with the nuclear lamina (NL) are thought to assist chromosome folding inside the nucleus and to contribute to the regulation of gene expression. High-resolution mapping has recently identified hundreds of large, sharply defined lamina-associated domains (LADs) in

  3. Secondary phases formed during nuclear waste glass-water interactions: Thermodynamic and derived properties

    International Nuclear Information System (INIS)

    McKenzie, W.F.

    1992-08-01

    The thermodynamic properties of secondary phases observed to form during nuclear waste glass-water interactions are of particular interest as it is with the application of these properties together with the thermodynamic properties of other solid phases, fluid phases, and aqueous species that one may predict the environmental consequences of introducing radionuclides contained in the glass into groundwater at a high-level nuclear waste repository. The validation of these predicted consequences can be obtained from laboratory experiments and field observations at natural analogue sites. The purpose of this report is to update and expand the previous compilation (McKenzie, 1991) of thermodynamic data retrieved from the literature and/or estimated for secondary phases observed to form (and candidate phases from observed chemical compositions) during nuclear waste glass-water interactions. In addition, this report includes provisionally recommended thermodynamic data of secondary phases

  4. Experiments on the nuclear interactions of pions and electrons

    International Nuclear Information System (INIS)

    Minehart, R.C.; Ziock, K.O.H.

    1992-08-01

    The analysis of the deuterium content in the CD target used in an experiment to study the π + d → 2p reaction at incident pion energies from 4 to 20 MeV was completed. The final paper describing this experiment will be submitted for publication this summer. Analysis of LAMPF Exp. on pion absorption in 4 He is continuing. In 1991, we collaborated with D. Pocanic from the Univ. of Virginia on a measurement at LAMPF of the π 0 production in π + p interactions. This run proved the validity of the method and additional data were obtained in a second run during the summer of 1992, using a new target. Current collaborations at LAMPF include the search for the decay μ + → e + + γ(MEGA) and a measurement of the Michel ρ parameter in the decay μ → e + v + v. A U.Va.--PSI collaboration is measuring pion beta decay to an accuracy of less than 1%, using a large acceptance CsI detector to measure the π 0 following decay of stopped π + mesons. Most of the U.Va. effort is devoted to the CEBAF Large Acceptance Spectrometer (CLAS) program to the construction of the CLAS forward calorimeter. An apparatus to measure the properties of the scintillators with light from a N 2 laser was built in the spring of 1992. The electronic circuitry for the energy signal from the EGN detector and the circuitry needed to route the signals from the all the photomultipliers to the TDC and ADC circuits are being developed. Experimental proposals for the study of electroproduction of nucleon resonances at CEBAF, including measurements with polarized beam and targets, are being developed

  5. Practical training in the operation of nuclear power plants with Interactive Graphic Simulator of Zorita

    International Nuclear Information System (INIS)

    Cuervo, D.; Garcia-Herranz, N.; Garcia, S.; Davila, R.; Ahnert, C.; Aragones, J. M.; Cabellos, O.; Gallego, E.; Lorente, A.; Minguez, E.; Rebollo, L.; Blanco, J.

    2010-01-01

    In April 2008 a collaboration agreement was signed between Gas Natural Union Fenosa and the Universad Politecnica de Madrid for the creation of the Aula Jose Cabrera dedicated to train professionals in the field of nuclear technology. The Classroom located in the Department of Nuclear Engineering, has been equipped with the Interactive Graphic Simulator of Zorita (SGIZ). The use of the simulator intended to improve the quality of teaching in the area of Nuclear Engineering. It integrates in the teachings of Industrial Engineering degree and the Master of Nuclear Science and Technology. Different manuals are under preparation to make it a suitable tool for teaching purpose. These manuals will guide the student so that learning takes place both through the guidance of the teacher as independently. (Author) 3 refs.

  6. Fundamental length

    International Nuclear Information System (INIS)

    Pradhan, T.

    1975-01-01

    The concept of fundamental length was first put forward by Heisenberg from purely dimensional reasons. From a study of the observed masses of the elementary particles known at that time, it is sumrised that this length should be of the order of magnitude 1 approximately 10 -13 cm. It was Heisenberg's belief that introduction of such a fundamental length would eliminate the divergence difficulties from relativistic quantum field theory by cutting off the high energy regions of the 'proper fields'. Since the divergence difficulties arise primarily due to infinite number of degrees of freedom, one simple remedy would be the introduction of a principle that limits these degrees of freedom by removing the effectiveness of the waves with a frequency exceeding a certain limit without destroying the relativistic invariance of the theory. The principle can be stated as follows: It is in principle impossible to invent an experiment of any kind that will permit a distintion between the positions of two particles at rest, the distance between which is below a certain limit. A more elegant way of introducing fundamental length into quantum theory is through commutation relations between two position operators. In quantum field theory such as quantum electrodynamics, it can be introduced through the commutation relation between two interpolating photon fields (vector potentials). (K.B.)

  7. Effect of nonlinearity of spin interaction with electromagnetic resonance field on characteristics of polarized nuclear target

    International Nuclear Information System (INIS)

    Vertij, A.A.; Gavrilov, S.P.; Shestopalov, V.P.

    1990-01-01

    Interaction of incident nuclear particle beam with J = 1/2 (neutrons) spin and (J = 1/2) protons with the target substance is considered. It is shown that neutron polarization at the target exit and neutron transparency (G) of the target depend significantly on incident wave amplitude level and physical parameter values which characterize the target, such as target temperature, resonator mirror reflection factor, number of spins interacting with the field, etc. Under interaction of neutrons with a target resonator which features a high mirror reflection factor and low losses for absorption which is not related to magnetic dipole absorption, a bistable response of neutron polarization and G manifests itself. 1 ref

  8. Tissue-specific interactions between nuclear proteins and the aminopeptidase N promoter

    DEFF Research Database (Denmark)

    Kärnström, U; Sjöström, H; Norén, O

    1991-01-01

    Aminopeptidase N/CD13 is a metallopeptidase found in many tissues. Aminopeptidase N activity is high in the small intestinal mucosa, moderate in the liver, and low in the spleen. Using DNase I footprinting and electrophoretic mobility shift assays with nuclear extracts from these tissues, three cis...... elements (DF, LF-B1, UF) were identified in the aminopeptidase N promoter. The DF region (-53 to -30) interacts with the ubiquitously expressed transcription factor Sp1. The LF-B1 region (-85 to -58) interacts with the liver transcription factor LF-B1 (HNF-1) which was detected as well in nuclei from small...... intestinal mucosa. The UF region (-112 to -90) interacts with nuclear factors which seem to be expressed differentially in the liver and the small intestine. Transfection of promoter deletions into HepG2 cells showed that the LF-B1 region is necessary for high expression of the aminopeptidase N gene in liver...

  9. Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting.

    Science.gov (United States)

    Smith, Kate M; Di Antonio, Veronica; Bellucci, Luca; Thomas, David R; Caporuscio, Fabiana; Ciccarese, Francesco; Ghassabian, Hanieh; Wagstaff, Kylie M; Forwood, Jade K; Jans, David A; Palù, Giorgio; Alvisi, Gualtiero

    2018-08-01

    Nuclear import involves the recognition by importin (IMP) superfamily members of nuclear localization signals (NLSs) within protein cargoes destined for the nucleus, the best understood being recognition of classical NLSs (cNLSs) by the IMPα/β1 heterodimer. Although the cNLS consensus [K-(K/R)-X-(K/R) for positions P2-P5] is generally accepted, recent studies indicated that the contribution made by different residues at the P4 position can vary. Here, we apply a combination of microscopy, molecular dynamics, crystallography, in vitro binding, and bioinformatics approaches to show that the nature of residues at P4 indeed modulates cNLS function in the context of a prototypical Simian Virus 40 large tumor antigen-derived cNLS (KKRK, P2-5). Indeed, all hydrophobic substitutions in place of R impaired binding to IMPα and nuclear targeting, with the largest effect exerted by a G residue at P4. Substitution of R with neutral hydrophobic residues caused the loss of electrostatic and van der Waals interactions between the P4 residue side chains and IMPα. Detailed bioinformatics analysis confirmed the importance of the P4 residue for cNLS function across the human proteome, with specific residues such as G being associated with low activity. Furthermore, we validate our findings for two additional cNLSs from human cytomegalovirus (HCMV) DNA polymerase catalytic subunit UL54 and processivity factor UL44, where a G residue at P4 results in a 2-3-fold decrease in NLS activity. Our results thus showed that the P4 residue makes a hitherto poorly appreciated contribution to nuclear import efficiency, which is essential to determining the precise nuclear levels of cargoes. Copyright © 2018 Elsevier B.V. All rights reserved.

  10. SU-E-T-270: Quality Control of Source Strength and Indexer Length in HDR Brachytherapy Using Sun Nuclear Mapcheck2

    International Nuclear Information System (INIS)

    Morales, J

    2014-01-01

    Purpose: The goal of this work was to evaluate Sun Nuclear MapCheck2 capability for quantitative determination of both HDR source strength and position. Predictive power of Mapcheck2 dose matrix, originated by a microSelectron-v2 source from 22mm distance, was investigated. Methods: A Mick MultiDoc phantom with the 1400mm indexer length mark aligned over MapCheck2 central detector plus two additional 5cm plastic slabs were used as a composite phantom. Dose readings were transformed by applying published source anisotropy corrections and experimentally established radial dose and relative sensitivity factors. Angular dependence was not considered. Only readings from diodes located 2cm around the central detector were evaluated. The reproducibility of a fit between transformed dose readings and the ratio of virtual source strength and the square of source-detector distance was investigated. Four parameters were considered in the model: virtual source strength, lateral, longitudinal and vertical source positions. Final source strength calibration factor was calculated from the ratio of reference measurements and results from the fit. Results: Original lateral and longitudinal source position estimations had systematic errors of 0.39mm and 0.75mm. After subtracting these errors, both source positions were predicted with a standard deviation of 0.15mm. Results for vertical positions were reproducible with a standard deviation of 0.05mm. The difference between calculated and reference source strengths from 34 independent measurement setups had a standard deviation of 0.3%. The coefficient of determination for the linear regression between known indexer lengths and results from the fit in the range 1400mm ± 5mm was 0.985. Conclusions: ource strength can be estimated with MapCheck2 at appropriate accuracy levels for quality control. Verification of indexer length with present implementation is more accurate than visual alternatives. Results can be improved by designing a

  11. A rare variant P507L in TPP1 interrupts TPP1-TIN2 interaction, influences telomere length, and confers colorectal cancer risk in Chinese population.

    Science.gov (United States)

    Li, Jiaoyuan; Chang, Jiang; Tian, Jianbo; Ke, Juntao; Zhu, Ying; Yang, Yang; Gong, Yajie; Zou, Danyi; Peng, Xiating; Yang, Nan; Mei, Shufang; Wang, Xiaoyang; Cheng, Liming; Hu, Weiguo; Gong, Jing; Zhong, Rong; Miao, Xiaoping

    2018-06-11

    Telomere dysfunction triggers cellular senescence and constitutes a driving force for cancer initiation. Genetic variants in genes involved in telomere maintenance may contribute to colorectal cancer (CRC) susceptibility. In this study, we firstly captured germline mutations in 192 CRC patients by sequencing the coding regions of 13 core components implicated in telomere biology. Five potential functional variants were then genotyped and assessed in a case-control set with 3,761 CRC cases and 3,839 healthy controls. The promising association was replicated in additional 6,765 cases and 6,906 controls. Functional experiments were used to further clarify the potential function of the significant variant and uncover the underlying mechanism in CRC development. The two-stage association studies showed that a rare missense variant rs149418249 (c.C1520T, p.P507L) in the 11th exon of TPP1 (also known as ACD, gene ID 65057) was significantly associated with CRC risk with the ORs being 2.90 (95% CI:1.04-8.07, P=0.041), 2.50 (95% CI:1.04-6.04, P=0.042), and 2.66 (95%CI:1.36-5.18, P=0.004) in discovery, replication, and the combined samples, respectively. Further functional annotation indicated that the TPP1 P507L substitution interrupted TPP1-TIN2 interaction, impaired telomerase processivity, and shortened telomere length, which subsequently facilitated cell proliferation and promoted CRC development. A rare variant P507L in TPP1 confers increased risk of CRC through interrupting TPP1-TIN2 interaction, impairing telomerase processivity, and shrinking telomere length. These findings emphasize the important role of telomere dysfunction in CRC development, and provide new insights about the prevention of this type of cancer. Copyright ©2018, American Association for Cancer Research.

  12. Interactive real-time nuclear plant simulations on a UNIX based supercomputer

    International Nuclear Information System (INIS)

    Behling, S.R.

    1990-01-01

    Interactive real-time nuclear plant simulations are critically important to train nuclear power plant engineers and operators. In addition, real-time simulations can be used to test the validity and timing of plant technical specifications and operational procedures. To accurately and confidently simulate a nuclear power plant transient in real-time, sufficient computer resources must be available. Since some important transients cannot be simulated using preprogrammed responses or non-physical models, commonly used simulation techniques may not be adequate. However, the power of a supercomputer allows one to accurately calculate the behavior of nuclear power plants even during very complex transients. Many of these transients can be calculated in real-time or quicker on the fastest supercomputers. The concept of running interactive real-time nuclear power plant transients on a supercomputer has been tested. This paper describes the architecture of the simulation program, the techniques used to establish real-time synchronization, and other issues related to the use of supercomputers in a new and potentially very important area. (author)

  13. The CCR4-NOT complex physically and functionally interacts with TRAMP and the nuclear exosome.

    Directory of Open Access Journals (Sweden)

    Nowel Azzouz

    Full Text Available BACKGROUND: Ccr4-Not is a highly conserved multi-protein complex consisting in yeast of 9 subunits, including Not5 and the major yeast deadenylase Ccr4. It has been connected functionally in the nucleus to transcription by RNA polymerase II and in the cytoplasm to mRNA degradation. However, there has been no evidence so far that this complex is important for RNA degradation in the nucleus. METHODOLOGY/PRINCIPAL FINDINGS: In this work we point to a new role for the Ccr4-Not complex in nuclear RNA metabolism. We determine the importance of the Ccr4-Not complex for the levels of non-coding nuclear RNAs, such as mis-processed and polyadenylated snoRNAs, whose turnover depends upon the nuclear exosome and TRAMP. Consistently, mutation of both the Ccr4-Not complex and the nuclear exosome results in synthetic slow growth phenotypes. We demonstrate physical interactions between the Ccr4-Not complex and the exosome. First, Not5 co-purifies with the exosome. Second, several exosome subunits co-purify with the Ccr4-Not complex. Third, the Ccr4-Not complex is important for the integrity of large exosome-containing complexes. Finally, we reveal a connection between the Ccr4-Not complex and TRAMP through the association of the Mtr4 helicase with the Ccr4-Not complex and the importance of specific subunits of Ccr4-Not for the association of Mtr4 with the nuclear exosome subunit Rrp6. CONCLUSIONS/SIGNIFICANCE: We propose a model in which the Ccr4-Not complex may provide a platform contributing to dynamic interactions between the nuclear exosome and its co-factor TRAMP. Our findings connect for the first time the different players involved in nuclear and cytoplasmic RNA degradation.

  14. A redefinition of the energy ansata, leading to a fundamentally new class of nuclear interactions

    International Nuclear Information System (INIS)

    Bearden, T.E.

    1992-01-01

    Utilizing fundamental new definitions for energy, potential, and scalar potential, the mass of the atomic nucleus may be considered a powerful electrostatic scalar potential, referred to as the mass potential. The Whittaker EM biwave structure of the scalar potential then becomes a new and universal internal EM structure for mass, including the atomic nucleus. This structure can be directly manipulated electromagnetically, which allows direct EM alteration of the mass potential , and the nucleus itself. This totally new class of nuclear interactions is briefly explored in this paper, and several hypothesized mechanisms advanced for neutralizing or processing nuclear wastes. Additional applications are hypothesized for experimental falsification or verification

  15. Validation of seismic soil structure interaction (SSI) methodology for a UK PWR nuclear power station

    International Nuclear Information System (INIS)

    Llambias, J.M.

    1993-01-01

    The seismic loading information for use in the seismic design of equipment and minor structures within a nuclear power plant is determined from a dynamic response analysis of the building in which they are located. This dynamic response analysis needs to capture the global response of both the building structure and adjacent soil and is commonly referred to as a soil structure interaction (SSI) analysis. NNC have developed a simple and cost effective methodology for the seismic SSI analysis of buildings in a PWR nuclear power station at a UK soft site. This paper outlines the NNC methodology and describes the approach adopted for its validation

  16. Investigation of the proton-neutron interaction by high-precision nuclear mass measurements

    CERN Multimedia

    Savreux, R P; Akkus, B

    2007-01-01

    We propose to measure the atomic masses of a series of short-lived nuclides, including $^{70}$Ni, $^{122-130}$Cd, $^{134}$Sn, $^{138,140}$Xe, $^{207-210}$Hg, and $^{223-225}$Rn, that contribute to the investigation of the proton-neutron interaction and its role in nuclear structure. The high-precision mass measurements are planned for the Penning trap mass spectrometer ISOLTRAP that reaches the required precision of 10 keV in the nuclear mass determination.

  17. Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction.

    Science.gov (United States)

    Poleshko, Andrey; Shah, Parisha P; Gupta, Mudit; Babu, Apoorva; Morley, Michael P; Manderfield, Lauren J; Ifkovits, Jamie L; Calderon, Damelys; Aghajanian, Haig; Sierra-Pagán, Javier E; Sun, Zheng; Wang, Qiaohong; Li, Li; Dubois, Nicole C; Morrisey, Edward E; Lazar, Mitchell A; Smith, Cheryl L; Epstein, Jonathan A; Jain, Rajan

    2017-10-19

    Progenitor cells differentiate into specialized cell types through coordinated expression of lineage-specific genes and modification of complex chromatin configurations. We demonstrate that a histone deacetylase (Hdac3) organizes heterochromatin at the nuclear lamina during cardiac progenitor lineage restriction. Specification of cardiomyocytes is associated with reorganization of peripheral heterochromatin, and independent of deacetylase activity, Hdac3 tethers peripheral heterochromatin containing lineage-relevant genes to the nuclear lamina. Deletion of Hdac3 in cardiac progenitor cells releases genomic regions from the nuclear periphery, leading to precocious cardiac gene expression and differentiation into cardiomyocytes; in contrast, restricting Hdac3 to the nuclear periphery rescues myogenesis in progenitors otherwise lacking Hdac3. Our results suggest that availability of genomic regions for activation by lineage-specific factors is regulated in part through dynamic chromatin-nuclear lamina interactions and that competence of a progenitor cell to respond to differentiation signals may depend upon coordinated movement of responding gene loci away from the nuclear periphery. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Spin-spin interactions of electrons and also of nucleons create atomic molecular and nuclear structures

    International Nuclear Information System (INIS)

    Kaliambos, L.A.

    2008-01-01

    Fundamental interactions of spinning electrons at an interelectron separation less than 578.8 fm yield attractive electromagnetic forces with S = 0 creating vibrations under a motional emf. They explain the indistinguishability of electrons and give a vibration energy able for calculating the ground-state energies of many-electron atoms without using any perturbative approximation. Such forces create two-electron orbitals able to account for the exclusion principal and the mechanism of covalent bonds. In the outer subshells of atoms the penetrating orbitals interact also as pair-pair systems and deform drastically the probability densities of the quantum mechanical electron clouds. Such a dynamics of deformation removes the degeneracy and leads to the deviation from the shell scheme. However in the interior of atoms the large nuclear charge leads to a spherically symmetric potential with non-interacting pairs for creating shells of degenerate states giving an accurate explanation of the X-ray lines. On the other hand, considerable charge distributions in nucleons as multiples of 2e/3 and - e/3 determined by the magnetic moments, interact for creating the nuclear structure with p-n bonds. Such spin-spin interactions show that the dominant concept of the untisymmetric wave function for fermions is inapplicable not only in the simple p-n, p-p, and n-n systems but also in the LS coupling of atoms in which the electrons interact from different quantum states giving either S = 0 or S = l. (author)

  19. Additional mitochondrial DNA influences the interactions between the nuclear and mitochondrial genomes in a bovine embryo model of nuclear transfer.

    Science.gov (United States)

    Srirattana, Kanokwan; St John, Justin C

    2018-05-08

    We generated cattle embryos using mitochondrial supplementation and somatic cell nuclear transfer (SCNT), named miNT, to determine how additional mitochondrial DNA (mtDNA) modulates the nuclear genome. To eliminate any confounding effects from somatic cell mtDNA in intraspecies SCNT, donor cell mtDNA was depleted prior to embryo production. Additional oocyte mtDNA did not affect embryo development rates but increased mtDNA copy number in blastocyst stage embryos. Moreover, miNT-derived blastocysts had different gene expression profiles when compared with SCNT-derived blastocysts. Additional mtDNA increased expression levels of genes involved in oxidative phosphorylation, cell cycle and DNA repair. Supplementing the embryo culture media with a histone deacetylase inhibitor, Trichostatin A (TSA), had no beneficial effects on the development of miNT-derived embryos, unlike SCNT-derived embryos. When compared with SCNT-derived blastocysts cultured in the presence of TSA, additional mtDNA alone had beneficial effects as the activity of glycolysis may increase and embryonic cell death may decrease. However, these beneficial effects were not found with additional mtDNA and TSA together, suggesting that additional mtDNA alone enhances reprogramming. In conclusion, additional mtDNA increased mtDNA copy number and expression levels of genes involved in energy production and embryo development in blastocyst stage embryos emphasising the importance of nuclear-mitochondrial interactions.

  20. New parameterizations of the Gogny effective nuclear interaction; Nouvelles parametrisations de l'interaction nucleaire effective de Gogny

    Energy Technology Data Exchange (ETDEWEB)

    Chappert, F

    2007-06-15

    The effective interaction between nucleons is the basic input to microscopic calculations in nuclear structure. One of the forms used since the 1970's is the phenomenological effective force proposed by D. Gogny. This force gives excellent results in nuclei at the mean-field approximation. The presence of contact terms does not allow, however, to use it for the description of beyond mean-field correlations present in nuclei. In this work, we investigate some extensions of the Gogny force, and especially a generalization in which the zero range density dependent term has been replaced by a finite range term. The parameters occurring in the analytical form of the force have been adjusted on symmetric infinite nuclear matter and neutron matter properties, and on some selected observables for stable nuclei, especially those related to pairing correlations. We present the method to include this kind of force in Hartree-Fock-Bogoliubov calculations and we analyze the results obtained for various nuclei. The new versions of the Gogny force allow us to reproduce nuclear structure properties with improved accuracy as compared to the former version. (author)

  1. Plastid-Nuclear Interaction and Accelerated Coevolution in Plastid Ribosomal Genes in Geraniaceae.

    Science.gov (United States)

    Weng, Mao-Lun; Ruhlman, Tracey A; Jansen, Robert K

    2016-06-27

    Plastids and mitochondria have many protein complexes that include subunits encoded by organelle and nuclear genomes. In animal cells, compensatory evolution between mitochondrial and nuclear-encoded subunits was identified and the high mitochondrial mutation rates were hypothesized to drive compensatory evolution in nuclear genomes. In plant cells, compensatory evolution between plastid and nucleus has rarely been investigated in a phylogenetic framework. To investigate plastid-nuclear coevolution, we focused on plastid ribosomal protein genes that are encoded by plastid and nuclear genomes from 27 Geraniales species. Substitution rates were compared for five sets of genes representing plastid- and nuclear-encoded ribosomal subunit proteins targeted to the cytosol or the plastid as well as nonribosomal protein controls. We found that nonsynonymous substitution rates (dN) and the ratios of nonsynonymous to synonymous substitution rates (ω) were accelerated in both plastid- (CpRP) and nuclear-encoded subunits (NuCpRP) of the plastid ribosome relative to control sequences. Our analyses revealed strong signals of cytonuclear coevolution between plastid- and nuclear-encoded subunits, in which nonsynonymous substitutions in CpRP and NuCpRP tend to occur along the same branches in the Geraniaceae phylogeny. This coevolution pattern cannot be explained by physical interaction between amino acid residues. The forces driving accelerated coevolution varied with cellular compartment of the sequence. Increased ω in CpRP was mainly due to intensified positive selection whereas increased ω in NuCpRP was caused by relaxed purifying selection. In addition, the many indels identified in plastid rRNA genes in Geraniaceae may have contributed to changes in plastid subunits. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  2. Plastid–Nuclear Interaction and Accelerated Coevolution in Plastid Ribosomal Genes in Geraniaceae

    Science.gov (United States)

    Weng, Mao-Lun; Ruhlman, Tracey A.; Jansen, Robert K.

    2016-01-01

    Plastids and mitochondria have many protein complexes that include subunits encoded by organelle and nuclear genomes. In animal cells, compensatory evolution between mitochondrial and nuclear-encoded subunits was identified and the high mitochondrial mutation rates were hypothesized to drive compensatory evolution in nuclear genomes. In plant cells, compensatory evolution between plastid and nucleus has rarely been investigated in a phylogenetic framework. To investigate plastid–nuclear coevolution, we focused on plastid ribosomal protein genes that are encoded by plastid and nuclear genomes from 27 Geraniales species. Substitution rates were compared for five sets of genes representing plastid- and nuclear-encoded ribosomal subunit proteins targeted to the cytosol or the plastid as well as nonribosomal protein controls. We found that nonsynonymous substitution rates (dN) and the ratios of nonsynonymous to synonymous substitution rates (ω) were accelerated in both plastid- (CpRP) and nuclear-encoded subunits (NuCpRP) of the plastid ribosome relative to control sequences. Our analyses revealed strong signals of cytonuclear coevolution between plastid- and nuclear-encoded subunits, in which nonsynonymous substitutions in CpRP and NuCpRP tend to occur along the same branches in the Geraniaceae phylogeny. This coevolution pattern cannot be explained by physical interaction between amino acid residues. The forces driving accelerated coevolution varied with cellular compartment of the sequence. Increased ω in CpRP was mainly due to intensified positive selection whereas increased ω in NuCpRP was caused by relaxed purifying selection. In addition, the many indels identified in plastid rRNA genes in Geraniaceae may have contributed to changes in plastid subunits. PMID:27190001

  3. Mitochondrial-nuclear genome interactions in non-alcoholic fatty liver disease in mice.

    Science.gov (United States)

    Betancourt, Angela M; King, Adrienne L; Fetterman, Jessica L; Millender-Swain, Telisha; Finley, Rachel D; Oliva, Claudia R; Crowe, David R; Ballinger, Scott W; Bailey, Shannon M

    2014-07-15

    NAFLD (non-alcoholic fatty liver disease) involves significant changes in liver metabolism characterized by oxidative stress, lipid accumulation and fibrogenesis. Mitochondrial dysfunction and bioenergetic defects also contribute to NAFLD. In the present study, we examined whether differences in mtDNA influence NAFLD. To determine the role of mitochondrial and nuclear genomes in NAFLD, MNX (mitochondrial-nuclear exchange) mice were fed an atherogenic diet. MNX mice have mtDNA from C57BL/6J mice on a C3H/HeN nuclear background and vice versa. Results from MNX mice were compared with wild-type C57BL/6J and C3H/HeN mice fed a control or atherogenic diet. Mice with the C57BL/6J nuclear genome developed more macrosteatosis, inflammation and fibrosis compared with mice containing the C3H/HeN nuclear genome when fed the atherogenic diet. These changes were associated with parallel alterations in inflammation and fibrosis gene expression in wild-type mice, with intermediate responses in MNX mice. Mice with the C57BL/6J nuclear genome had increased State 4 respiration, whereas MNX mice had decreased State 3 respiration and RCR (respiratory control ratio) when fed the atherogenic diet. Complex IV activity and most mitochondrial biogenesis genes were increased in mice with the C57BL/6J nuclear or mitochondrial genome, or both fed the atherogenic diet. These results reveal new interactions between mitochondrial and nuclear genomes and support the concept that mtDNA influences mitochondrial function and metabolic pathways implicated in NAFLD.

  4. Mitochondrial-nuclear genome interactions in nonalcoholic fatty liver disease in mice

    Science.gov (United States)

    Betancourt, Angela M.; King, Adrienne L.; Fetterman, Jessica L.; Millender-Swain, Telisha; Finley, Rachel D.; Oliva, Claudia R.; Crowe, David Ralph; Ballinger, Scott W.; Bailey, Shannon M.

    2014-01-01

    Nonalcoholic fatty liver disease (NAFLD) involves significant changes in liver metabolism characterized by oxidative stress, lipid accumulation, and fibrogenesis. Mitochondrial dysfunction and bioenergetic defects also contribute to NAFLD. Herein, we examined whether differences in mtDNA influence NAFLD. To determine the role of mitochondrial and nuclear genomes in NAFLD, Mitochondrial-Nuclear eXchange (MNX) mice were fed an atherogenic diet. MNX mice have mtDNA from C57BL/6J mice on a C3H/HeN nuclear background and vice versa. Results from MNX mice were compared to wild-type C57BL/6J and C3H/HeN mice fed a control or atherogenic diet. Mice with the C57BL/6J nuclear genome developed more macrosteatosis, inflammation, and fibrosis compared with mice containing the C3H/HeN nuclear genome when fed the atherogenic diet. These changes were associated with parallel alterations in inflammation and fibrosis gene expression in wild-type mice, with intermediate responses in MNX mice. Mice with the C57BL/6J nuclear genome had increased State 4 respiration, whereas MNX mice had decreased State 3 respiration and RCR when fed the atherogenic diet. Complex IV activity and most mitochondrial biogenesis genes were increased in mice with the C57BL/6J nuclear or mitochondrial genome, or both fed the atherogenic diet. These results reveal new interactions between mitochondrial and nuclear genomes and support the concept that mtDNA influences mitochondrial function and metabolic pathways implicated in NAFLD. PMID:24758559

  5. FENDL/E. Evaluated nuclear data library of neutron nuclear interaction cross-sections and photon production cross-sections and photon-atom interaction cross sections for fusion applications. Version 1.1 of November 1994

    International Nuclear Information System (INIS)

    Pashchenko, A.B.; Wienke, H.; Ganesan, S.; McLaughlin, P.K.

    1996-01-01

    This document presents the description of a physical tape containing the basic evaluated nuclear data library of neutron nuclear interaction cross-sections and photon production cross-sections and photon-atom interaction cross-sections for fusion applications. It is part of FENDL, the evaluated nuclear data library for fusion applications. The nuclear data are available cost-free for distribution to interested scientists upon request. The data can also be retrieved by the user via online access through international computer networks. (author). 11 refs, 1 tab

  6. Complete genome sequence and integrated protein localization and interaction map for alfalfa dwarf virus, which combines properties of both cytoplasmic and nuclear plant rhabdoviruses

    Energy Technology Data Exchange (ETDEWEB)

    Bejerman, Nicolás, E-mail: n.bejerman@uq.edu.au [Instituto de Patología Vegetal (IPAVE), Centro de Investigaciones Agropecuarias (CIAP), Instituto Nacional de Tecnología Agropecuaria INTA, Camino a 60 Cuadras k 5,5, Córdoba X5020ICA (Argentina); Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, QLD 4072 (Australia); Giolitti, Fabián; Breuil, Soledad de; Trucco, Verónica; Nome, Claudia; Lenardon, Sergio [Instituto de Patología Vegetal (IPAVE), Centro de Investigaciones Agropecuarias (CIAP), Instituto Nacional de Tecnología Agropecuaria INTA, Camino a 60 Cuadras k 5,5, Córdoba X5020ICA (Argentina); Dietzgen, Ralf G. [Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, QLD 4072 (Australia)

    2015-09-15

    Summary: We have determined the full-length 14,491-nucleotide genome sequence of a new plant rhabdovirus, alfalfa dwarf virus (ADV). Seven open reading frames (ORFs) were identified in the antigenomic orientation of the negative-sense, single-stranded viral RNA, in the order 3′-N-P-P3-M-G-P6-L-5′. The ORFs are separated by conserved intergenic regions and the genome coding region is flanked by complementary 3′ leader and 5′ trailer sequences. Phylogenetic analysis of the nucleoprotein amino acid sequence indicated that this alfalfa-infecting rhabdovirus is related to viruses in the genus Cytorhabdovirus. When transiently expressed as GFP fusions in Nicotiana benthamiana leaves, most ADV proteins accumulated in the cell periphery, but unexpectedly P protein was localized exclusively in the nucleus. ADV P protein was shown to have a homotypic, and heterotypic nuclear interactions with N, P3 and M proteins by bimolecular fluorescence complementation. ADV appears unique in that it combines properties of both cytoplasmic and nuclear plant rhabdoviruses. - Highlights: • The complete genome of alfalfa dwarf virus is obtained. • An integrated localization and interaction map for ADV is determined. • ADV has a genome sequence similarity and evolutionary links with cytorhabdoviruses. • ADV protein localization and interaction data show an association with the nucleus. • ADV combines properties of both cytoplasmic and nuclear plant rhabdoviruses.

  7. Complete genome sequence and integrated protein localization and interaction map for alfalfa dwarf virus, which combines properties of both cytoplasmic and nuclear plant rhabdoviruses

    International Nuclear Information System (INIS)

    Bejerman, Nicolás; Giolitti, Fabián; Breuil, Soledad de; Trucco, Verónica; Nome, Claudia; Lenardon, Sergio; Dietzgen, Ralf G.

    2015-01-01

    Summary: We have determined the full-length 14,491-nucleotide genome sequence of a new plant rhabdovirus, alfalfa dwarf virus (ADV). Seven open reading frames (ORFs) were identified in the antigenomic orientation of the negative-sense, single-stranded viral RNA, in the order 3′-N-P-P3-M-G-P6-L-5′. The ORFs are separated by conserved intergenic regions and the genome coding region is flanked by complementary 3′ leader and 5′ trailer sequences. Phylogenetic analysis of the nucleoprotein amino acid sequence indicated that this alfalfa-infecting rhabdovirus is related to viruses in the genus Cytorhabdovirus. When transiently expressed as GFP fusions in Nicotiana benthamiana leaves, most ADV proteins accumulated in the cell periphery, but unexpectedly P protein was localized exclusively in the nucleus. ADV P protein was shown to have a homotypic, and heterotypic nuclear interactions with N, P3 and M proteins by bimolecular fluorescence complementation. ADV appears unique in that it combines properties of both cytoplasmic and nuclear plant rhabdoviruses. - Highlights: • The complete genome of alfalfa dwarf virus is obtained. • An integrated localization and interaction map for ADV is determined. • ADV has a genome sequence similarity and evolutionary links with cytorhabdoviruses. • ADV protein localization and interaction data show an association with the nucleus. • ADV combines properties of both cytoplasmic and nuclear plant rhabdoviruses

  8. The nuclear equation of state: A tool to constrain in-medium hadronic interactions

    International Nuclear Information System (INIS)

    Sammarruca, F.; Krastev, P. G.

    2006-01-01

    Recently we have been concerned with the properties of the nuclear equation of state (EOS), a relation between thermodynamic variables characterizing a medium. At zero temperature, such relation can be expressed in terms of energy (or pressure) as a function of density. Mechanisms such as isospin and/or spin asymmetry can have a dramatic impact on the equation of state. After briefly reviewing our previous work concerning the isospin asymmetries of the EOS, we will concentrate on our most recent results and their relevance towards a better understanding of the nuclear force in exotic matter. The approach we take is microscopic and relativistic. The calculated EOS properties are derived self-consistently from realistic nucleon-nucleon interactions. This makes it possible to understand the predictions in terms of specific features of the nuclear force model.

  9. Antiferromagnetic spin phase transition in nuclear matter with effective Gogny interaction

    International Nuclear Information System (INIS)

    Isayev, A.A.; Yang, J.

    2004-01-01

    The possibility of ferromagnetic and antiferromagnetic phase transitions in symmetric nuclear matter is analyzed within the framework of a Fermi liquid theory with the effective Gogny interaction. It is shown that at some critical density nuclear matter with the D1S effective force undergoes a phase transition to the antiferromagnetic spin state (opposite directions of neutron and proton spins). The self-consistent equations of spin polarized nuclear matter with the D1S force have no solutions corresponding to ferromagnetic spin ordering (the same direction of neutron and proton spins) and, hence, the ferromagnetic transition does not appear. The dependence of the antiferromagnetic spin polarization parameter as a function of density is found at zero temperature

  10. Time-domain soil-structure interaction analysis of nuclear facilities

    International Nuclear Information System (INIS)

    Coleman, Justin L.; Bolisetti, Chandrakanth; Whittaker, Andrew S.

    2016-01-01

    The Nuclear Regulatory Commission (NRC) regulation 10 CFR Part 50 Appendix S requires consideration of soil-structure interaction (SSI) in nuclear power plant (NPP) analysis and design. Soil-structure interaction analysis for NPPs is routinely carried out using guidance provided in the ASCE Standard 4-98 titled “Seismic Analysis of Safety-Related Nuclear Structures and Commentary”. This Standard, which is currently under revision, provides guidance on linear seismic soil-structure-interaction (SSI) analysis of nuclear facilities using deterministic and probabilistic methods. A new appendix has been added to the forthcoming edition of ASCE Standard 4 to provide guidance for time-domain, nonlinear SSI (NLSSI) analysis. Nonlinear SSI analysis will be needed to simulate material nonlinearity in soil and/or structure, static and dynamic soil pressure effects on deeply embedded structures, local soil failure at the foundation-soil interface, nonlinear coupling of soil and pore fluid, uplift or sliding of the foundation, nonlinear effects of gaps between the surrounding soil and the embedded structure and seismic isolation systems, none of which can be addressed explicitly at present. Appendix B of ASCE Standard 4 provides general guidance for NLSSI analysis but will not provide a methodology for performing the analysis. This paper provides a description of an NLSSI methodology developed for application to nuclear facilities, including NPPs. This methodology is described as series of sequential steps to produce reasonable results using any time-domain numerical code. These steps require some numerical capabilities, such as nonlinear soil constitutive models, which are also described in the paper.

  11. Institutional interactions in developing a transportation system under the Nuclear Waste Policy Act

    International Nuclear Information System (INIS)

    Denny, S.H.

    1986-01-01

    The Department of Energy (DOE) recognizes that the success of its efforts to develop and operate a system for transporting nuclear waste under the provisions of the Nuclear Waste Policy Act of 1982 (NWPA) depends in large measure on the effectiveness of Departmental interactions with the affected parties. To ensure the necessary network of communication, the DOE is establishing lines of contact with those who are potential participants in the task of developing the policies and procedures for the NWPA transportation system. In addition, a number of measures have been initiated to reinforce broad-based involvement in program development. The Transportation Institutional Plan provides a preliminary road map of DOE's projected interactions over the next decade and is discussed in this paper

  12. Azimuthal angle dependence of Coulomb and nuclear interactions between two deformed nuclei

    International Nuclear Information System (INIS)

    Ismail, M.; Ellithi, A. Y.; Botros, M. M.; Mellik, A. E.

    2007-01-01

    The azimuthal angle (φ) variation of the Coulomb and nuclear heavy ion (HI) potentials is studied in the framework of the double folding model, which is derived from realistic nuclear density distributions and a nucleon-nucleon (NN) interaction. The present calculation shows that the variation of HI potentials with the azimuthal angle depends strongly on the range of the NN forces. For the long-range Coulomb force, the maximum variation with φ is about 0.9%, and for HI potential derived from zero-range NN interaction the φ-variation can reach up to 90.0%. Our calculations are compared with the recent φ-dependence of the HI potential derived from proximity method. The present realistic φ-dependence calculations of the HI potential is completely different from the results of the proximity calculations

  13. A full-configuration-interaction nuclear orbital approach and application for small doped He clusters

    Energy Technology Data Exchange (ETDEWEB)

    Lara-Castells, M. P. de, E-mail: delara@iff.csic.es; Aguirre, N. F., E-mail: delara@iff.csic.es; Delgado-Barrio, G., E-mail: delara@iff.csic.es; Villarreal, P., E-mail: delara@iff.csic.es [Instituto de Física Fundamental (CSIC), Serrano 123, 28006 Madrid (Spain); Mitrushchenkov, A. O. [Université Paris-Est, Laboratoire Modélisation et Simulation Multi Echelle, MSME UMR 8208 CNRS, 5 bd Descartes, 77454 Marne-la-Vallée (France)

    2015-01-22

    An efficient full-configuration-interaction 'nuclear orbital' treatment was developed as a benchmark quantum-chemistry-like method to calculate, ground and excited, fermionic 'solvent' wave-functions and applied to {sup 3}He{sub N} clusters with atomic or molecular impurities [J. Chem. Phys. (Communication) 125, 221101 (2006)]. The main difficulty in handling doped {sup 3}He{sub N} clusters lies in the Fermi-Dirac nuclear statistics, the wide amplitudes of the He-dopant and He-He motions, and the hard-core He-He interaction at short distances. This paper overviews the theoretical approach and its recent applications to energetic, structural and spectroscopic aspects of different dopant-{sup 3}He{sub N} clusters. Preliminary results by using the latest version of the FCI-NO computational implementation, to bosonic Cl{sub 2}(X)-({sup 4}He){sub N} clusters, are also shown.

  14. Materials interactions relating to long-term geologic disposal of nuclear waste glass

    International Nuclear Information System (INIS)

    Bibler, N.E.; Jantzen, C.M.

    1987-01-01

    In the geologic disposal of nuclear waste glass, the glass will eventually interact with groundwater in the repository system. Interactions can also occur between the glass and other waste package materials that are present. These include the steel canister that holds the glass, the metal overpack over the canister, backfill materials that may be used, and the repository host rock. This review paper systematizes the additional interactions that materials in the waste package will impose on the borosilicate glass waste form-groundwater interactions. The repository geologies reviewed are tuff, salt, basalt, and granite. The interactions emphasized are those appropriate to conditions expected after repository closure, e.g. oxic vs anoxic conditions. Whenever possible, the effect of radiation from the waste form on the interactions is examined. The interactions are evaluated based on their effect on the release and speciation of various elements including radionuclides from the glass. It is noted when further tests of repository interactions are needed before long-term predictions can be made. 63 references, 1 table

  15. Extended fuel cycle length

    International Nuclear Information System (INIS)

    Bruyere, M.; Vallee, A.; Collette, C.

    1986-09-01

    Extended fuel cycle length and burnup are currently offered by Framatome and Fragema in order to satisfy the needs of the utilities in terms of fuel cycle cost and of overall systems cost optimization. We intend to point out the consequences of an increased fuel cycle length and burnup on reactor safety, in order to determine whether the bounding safety analyses presented in the Safety Analysis Report are applicable and to evaluate the effect on plant licensing. This paper presents the results of this examination. The first part indicates the consequences of increased fuel cycle length and burnup on the nuclear data used in the bounding accident analyses. In the second part of this paper, the required safety reanalyses are presented and the impact on the safety margins of different fuel management strategies is examined. In addition, systems modifications which can be required are indicated

  16. Non-statistical fluctuations in fragmentation of target nuclei in high energy nuclear interactions

    Energy Technology Data Exchange (ETDEWEB)

    Ghosh, Dipak; Ghosh, Premomoy; Ghosh, Alokananda; Roy, Jaya [Jadavpur Univ., Calcutta (India)

    1994-07-01

    Analysis of target fragmented ''black'' particles in nuclear emulsion from high energy relativistic interactions initiated by [sup 16]O at 2.1 GeV/nucleon and [sup 12]C and [sup 24]Mg at 4.5 GeV/nucleon reveal the existence of non-statistical fluctuations in the azimuthal plane of interaction. The asymmetry or the non-statistical fluctuations, while found to be independent of projectile mass or incident energy, are dependent on the excitation energy of the target nucleus. (Author).

  17. Non-statistical fluctuations in fragmentation of target nuclei in high energy nuclear interactions

    International Nuclear Information System (INIS)

    Ghosh, Dipak; Ghosh, Premomoy; Ghosh, Alokananda; Roy, Jaya

    1994-01-01

    Analysis of target fragmented ''black'' particles in nuclear emulsion from high energy relativistic interactions initiated by 16 O at 2.1 GeV/nucleon and 12 C and 24 Mg at 4.5 GeV/nucleon reveal the existence of non-statistical fluctuations in the azimuthal plane of interaction. The asymmetry or the non-statistical fluctuations, while found to be independent of projectile mass or incident energy, are dependent on the excitation energy of the target nucleus. (Author)

  18. Measurement of Nuclear Interaction Rates in Crystal Using the CERN-SPS North Area Test Beams

    CERN Document Server

    Losito, R; Taratin, A

    2010-01-01

    A number of tests were performed in the North area of the SPS in view of investigating crystal-particles interactions for future application in hadron colliders. The rate of nuclear interactions was measured with 400 GeV proton beams directed into a silicon bent crystal. In this way the background induced by the crystal either in amorphous or in channeling orientation was revealed. The results provide fundamental information to put in perspective the use of silicon crystals to assist halo collimation in hadron colliders, whilst minimizing the induced loss.

  19. Percolation Model of Nuclear Multifragmentation in High Energy Nucleus-Nucleus Interactions

    International Nuclear Information System (INIS)

    Abdel-Waged, Kh.

    1994-01-01

    A hybrid model based on Reggeon theory inspired model of nuclear distribution, which was successful in explaining the cascading of particles in high energy nucleus-nucleus interactions, and percolation model is proposed. In the framework of this model the yield of the fragment in p + Ag, Au at 350 GeV and C + Ag, Au at 3.6 GeV/nucleon as well as the charge distribution of fragments in Kr, Xe and U interactions with emulsion at ∼ 1 GeV/nucleon is correctly described. 32 refs., 3 figs

  20. Interaction between core analysis methodology and nuclear design: some PWR examples

    International Nuclear Information System (INIS)

    Rothleder, B.M.; Eich, W.J.

    1982-01-01

    The interaction between core analysis methodology and nuclear design is exemplified by PSEUDAX, a major improvement related to the Advanced Recycle methodology program (ARMP) computer code system, still undergoing development by the Electric Power Research Institute. The mechanism of this interaction is explored by relating several specific nulcear design changes to the demands placed by these changes on the ARMP system, and by examining the meeting of these demands, first within the standard ARMP methodology and then through augmentation of the standard methodology by development of PSEUDAX

  1. On evaluation of the nuclear interaction effect on muon sticking in μ-catalyzed dt synthesis

    International Nuclear Information System (INIS)

    Khiger, L.Ya.

    1994-01-01

    The effect of nucler interaction on the muon -alpha-particle sticking coefficient is considered on the basis of the previously developed formalism of description of the deuterium and tritium nuclei muon catalysed fusion. The account of Coulomb interaction between the muon and nuclear subsystem in the intermediate state is shown to change substantially this coefficient. The results of numerical calculations of the sticking coefficient are presented, the value of the coefficient turns out to be 3 - 4% higher than that found in the sudden approximation

  2. Double-Lambda hypernuclei and the nuclear medium effective Lambda Lambda interaction

    OpenAIRE

    Caro, José; García Recio, Carmen; Nieves Pamplona, Juan Miguel

    1999-01-01

    We fit the $^1 S_0 \\Lambda\\Lambda$ interaction in the nuclear medium to the masses of the experimentally known double-$\\Lambda$ hypernuclei: $^{\\phantom{6}6}_{\\Lambda\\Lambda}$He, $^{10}_{\\Lambda\\Lambda}$Be and $^{13}_{\\Lambda\\Lambda}$B. We derive this effective interaction from OBE J\\"ulich $\\Lambda\\Lambda$-type potentials and using both Hartree-Fock and variational approaches. We find that the inclusion of $\\Lambda\\Lambda$ correlations in the variational scheme leads to significant differenc...

  3. In-medium eta N interactions and eta nuclear bound states

    Czech Academy of Sciences Publication Activity Database

    Cieplý, Aleš; Friedman, E.; Gal, A.; Mareš, Jiří

    2014-01-01

    Roč. 925, MAY (2014), s. 126-140 ISSN 0375-9474 R&D Projects: GA ČR(CZ) GAP203/12/2126; GA MŠk LG14038 Institutional support: RVO:61389005 Keywords : N(star) (1535 resonance * meson-baryon interactions * mesons in nuclear matter * mesic nuclei Subject RIV: BE - Theoretical Physics Impact factor: 2.202, year: 2014

  4. Nuclear quadrupole interactions in ferroelectric compounds of HF/sup 181/

    Energy Technology Data Exchange (ETDEWEB)

    Kunzler, J V

    1971-01-01

    Measurements of nuclear quadrupole interaction constants in perovkite-type compounds of PbHfO/sub 3/, SnhfO/sub 3/, CaHfO/sub 3/ e SrHfO/sub 3/ have been performed using the perturbed angular correlation technique. A range of fundamental frequencies from 150 to 550 Megaradians per second was determined. The variation of quadrupole constants has been discussed through the molecular orbital theory.

  5. The proteins of intra-nuclear bodies: a data-driven analysis of sequence, interaction and expression

    Directory of Open Access Journals (Sweden)

    Bodén Mikael

    2010-04-01

    Full Text Available Abstract Background Cajal bodies, nucleoli, PML nuclear bodies, and nuclear speckles are morpohologically distinct intra-nuclear structures that dynamically respond to cellular cues. Such nuclear bodies are hypothesized to play important regulatory roles, e.g. by sequestering and releasing transcription factors in a timely manner. While the nucleolus and nuclear speckles have received more attention experimentally, the PML nuclear body and the Cajal body are still incompletely characterized in terms of their roles and protein complement. Results By collating recent experimentally verified data, we find that almost 1000 proteins in the mouse nuclear proteome are known to associate with one or more of the nuclear bodies. Their gene ontology terms highlight their regulatory roles: splicing is confirmed to be a core activity of speckles and PML nuclear bodies house a range of proteins involved in DNA repair. We train support-vector machines to show that nuclear proteins contain discriminative sequence features that can be used to identify their intra-nuclear body associations. Prediction accuracy is highest for nucleoli and nuclear speckles. The trained models are also used to estimate the full protein complement of each nuclear body. Protein interactions are found primarily to link proteins in the nuclear speckles with proteins from other compartments. Cell cycle expression data provide support for increased activity in nucleoli, nuclear speckles and PML nuclear bodies especially during S and G2 phases. Conclusions The large-scale analysis of the mouse nuclear proteome sheds light on the functional organization of physically embodied intra-nuclear compartments. We observe partial support for the hypothesis that the physical organization of the nucleus mirrors functional modularity. However, we are unable to unambiguously identify proteins' intra-nuclear destination, suggesting that critical drivers behind of intra-nuclear translocation are yet to

  6. Effects of nuclear structure in the spin-dependent scattering of weakly interacting massive particles

    Science.gov (United States)

    Nikolaev, M. A.; Klapdor-Kleingrothaus, H. V.

    1993-06-01

    We present calculations of the nuclear from factors for spin-dependent elastic scattering of dark matter WIMPs from123Te and131Xe isotopes, proposed to be used for dark matter detection. A method based on the theory of finite Fermi systems was used to describe the reduction of the single-particle spin-dependent matrix elements in the nuclear medium. Nucleon single-particle states were calculated in a realistic shell model potential; pairing effects were treated within the BCS model. The coupling of the lowest single-particle levels in123Te to collective 2+ excitations of the core was taken into account phenomenologically. The calculated nuclear form factors are considerably less then the single-particle ones for low momentum transfer. At high momentum transfer some dynamical amplification takes place due to the pion exchange term in the effective nuclear interaction. But as the momentum transfer increases, the difference disappears, the momentum transfer increases and the quenching effect disappears. The shape of the nuclear form factor for the131Xe isotope differs from the one obtained using an oscillator basis.

  7. Effects of nuclear structure in the spin-dependent scattering of weakly interacting massive particles

    International Nuclear Information System (INIS)

    Nikolaev, M.A.; Klapdor-Kleingrothaus, H.V.

    1993-01-01

    We present calculations of the nuclear from factors for spin-dependent elastic scattering of dark matter WIMPs from 123 Te and 131 Xe isotopes, proposed to be used for dark matter detection. A method based on the theory of finite Fermi systems was used to describe the reduction of the single-particle spin-dependent matrix elements in the nuclear medium. Nucelon single-particle states were calculated in a realistic shell model potential; pairing effects were treated within the BCS model. The coupling of the lowest single-particle levels in 123 Te to collective 2 + excitations of the core was taken into account phenomenologically. The calculated nuclear form factors are considerably less then the single-particle ones for low momentum transfer. At high momentum transfer some dynamical amplification takes place due to the pion exchange term in the effective nuclear interaction. But as the momentum transfer increases, the difference disappears, the momentum transfer increases and quenching effect disappears. The shape of the nuclear form factor for the 131 Xe isotope differs from the one obtained using an oscillator basis. (orig.)

  8. Education and training of future nuclear engineers through the use of an interactive plant simulator

    International Nuclear Information System (INIS)

    Ahnert, C.; Cuervo, D.; Garcia-Herranz, N.; Aragones, J.M.; Cabellos, O.; Gallego, E.; Minguez, E.; Lorente, A.; Piedra, D.; Rebollo, L.; Blanco, J.

    2010-01-01

    The International Atomic Energy Agency (IAEA) sponsors the development of nuclear reactor simulators for education, or arranges the supply of such simulation programs. Aware of this, the Department of Nuclear Engineering of the Universidad Politecnica de Madrid was provided in 2008 with the Interactive Graphical Simulator of the Spanish nuclear power plant Jose Cabrera, whose operation ceased definitively in 2006. According with the IAEA-TECDOC- 1411, the simulator is a Graphical Simulator, used for training of main control room personnel, technical support engineers, and operations management. This paper presents all the work performed at the Department to turn the simulator into a teaching/learning tool, to be use in the nuclear engineering studies following guidance found in: Shtub, A. Parush, T.T. Hewett 'The use of simulation in learning and teaching' (Int. J. Eng. Educ., 25(2), 2009, pp. 206-208). The experience obtained so far with the use of the simulator has been very successful. The graduate students involved in the development of the projects, practices and documents related with the simulator show a great interest for the work that they are doing making that the laboratory where the simulator is installed to be busy place. Regarding the undergraduate students, the practices in the simulator encourage them to follow the Nuclear Energy studies in the Engineering Schools, what is very rewarding for the Department professors. The simulator has proved to be an optimal tool to transfer the knowledge of the physical phenomena that are involved in the nuclear power plants, from the nuclear reactor to the whole set of systems and equipments on a nuclear power plant. It is also a relevant tool for motivation of the students, and to complete the theoretical lessons. This use of the simulator in the learning-teaching process meats also the criteria recommended for the Bologna adapted studies, as it helps to increase the private hands-on work of the student, and

  9. Study by nuclear techniques of the impurity-defect interaction in implanted metals

    International Nuclear Information System (INIS)

    Thome, Lionel.

    1978-01-01

    The properties of out equilibrium alloys formed by impurity implantation are strongly influenced by radiation damage created during implantation. This work presents a study, via hyperfine interaction and lattice location experiments, of the impurity-defect interaction in ion implanted metals. When the impurity and defect concentrations in the implanted layer are small, i.e. when impurities are uniformly recoil implanted in the whole crystal volume following a nuclear reaction (Aq In experiments), the impurity interacts with its own damage cascade. In this case, a vacancy is found to be trapped by a fraction of impurities during an athermal process. The value of this fraction does not seem to depend critically on impurity and host. When the impurity and defect concentrations are such that defect cascades interact, i.e. when impurities are implanted with an isotope separator (Fe Yb experiments), the observed impurity-vacancy (or vacancy cluster) interactions depend then strongly on the nature of impurity and host. An empirical relation, which indicates the importance of elastic effects, has been found between the proportion of impurities interacting with defects and the difference between impurity and host atom radii. At implantation temperature such that vacancies are mobile, the impurity-defect interaction depends essentially on vacancy migration. A model based on chemical kinetics has been developed to account for the variation with temperature of measured quantities [fr

  10. Influence of nuclear interactions in body tissues on tumor dose in carbon-ion radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Inaniwa, T., E-mail: taku@nirs.go.jp; Kanematsu, N. [Medical Physics Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Anagawa 4-9-1, Inage-ku, Chiba 263-8555 (Japan); Tsuji, H.; Kamada, T. [Hospital, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan)

    2015-12-15

    Purpose: In carbon-ion radiotherapy treatment planning, the planar integrated dose (PID) measured in water is applied to the patient dose calculation with density scaling using the stopping power ratio. Since body tissues are chemically different from water, this dose calculation can be subject to errors, particularly due to differences in inelastic nuclear interactions. In recent studies, the authors proposed and validated a PID correction method for these errors. In the present study, the authors used this correction method to assess the influence of these nuclear interactions in body tissues on tumor dose in various clinical cases. Methods: Using 10–20 cases each of prostate, head and neck (HN), bone and soft tissue (BS), lung, liver, pancreas, and uterine neoplasms, the authors first used treatment plans for carbon-ion radiotherapy without nuclear interaction correction to derive uncorrected dose distributions. The authors then compared these distributions with recalculated distributions using the nuclear interaction correction (corrected dose distributions). Results: Median (25%/75% quartiles) differences between the target mean uncorrected doses and corrected doses were 0.2% (0.1%/0.2%), 0.0% (0.0%/0.0%), −0.3% (−0.4%/−0.2%), −0.1% (−0.2%/−0.1%), −0.1% (−0.2%/0.0%), −0.4% (−0.5%/−0.1%), and −0.3% (−0.4%/0.0%) for the prostate, HN, BS, lung, liver, pancreas, and uterine cases, respectively. The largest difference of −1.6% in target mean and −2.5% at maximum were observed in a uterine case. Conclusions: For most clinical cases, dose calculation errors due to the water nonequivalence of the tissues in nuclear interactions would be marginal compared to intrinsic uncertainties in treatment planning, patient setup, beam delivery, and clinical response. In some extreme cases, however, these errors can be substantial. Accordingly, this correction method should be routinely applied to treatment planning in clinical practice.

  11. Nuclear quadrupole interaction measurements of 19F* and 22Na* on Graphite

    International Nuclear Information System (INIS)

    Djoko-Surono, Th; Martin, Peter W

    1996-01-01

    Time differential perturbed angular distribution (TDPAD) technique has been used to investigate nuclear quadrupole interactions of 19 F * and 22 Na * in graphite. We concentrated the measurements on pseudo single crystal graphite called Highly Oriented Pyrolytic Graphite for it has an ordered structure in which the c-axes of the microcrystals aligned in a certain direction with the mosaic spread less than 1 o , while the a- and b-axes randomly oriented on a plane perpendicular to the c-axes. Interactions between quadrupole moment of 19 F * and 22 Na * with its surroundings electric field gradient were studied by detecting the γ-rays distribution, W(Θ,t). For 1 9F * we found one static interaction. The corresponding electric field gradient was V zz =3.24(19)x10 22 V/m 2 . In the case of 22 Na * we found no evidence of nuclear quadrupole interaction, however, we were able to conclude that |QV 22 | 19 bV/m 2 . Using theoretical calculation Q=0.06 barn, we find that |V zz | 20 V/m 2 . These results indicate that the value efg depend on two factors, the host crystal and the core electrons. The core electrons contribution to the total efg is considerably large

  12. Soil-structure interaction in nuclear power plants: a comparison of methods

    International Nuclear Information System (INIS)

    Wight, L.H.

    1976-06-01

    We performed an extensive parametric survey to analyze the differences between two methods of calculating soil-structure interaction. One method involves discretizing the soil-structure system and solving for the complete response with the LUSH computer code. The other method solves for the lumped mass structural response with Whitman soil springs. Twelve soil-structure interaction problems are solved by each of these methods. Representative results are presented and discussed. The debate within the nuclear industry in the United States over the relative merits of various methods of calculating soil-structure interaction has intensified over the last three years. The debate is largely the result of the U.S. Nuclear Regulatory Commission's position generally favoring the finite element approach. Certain sectors of the industry claim that this ruling is without technical basis, that it requires unnecessary expense, and that it inhibits the judgment of the analyst. We have addressed each of these points through lumped mass and finite element calculations on a set of twelve soil-structure interaction problems. The results of these calculations indicate some of the consequences of the choice of method

  13. Radiation interaction with substance and simulation of the nuclear geophysical problems

    International Nuclear Information System (INIS)

    Pshenichnyj, G.A.

    1982-01-01

    Main processes of interaction of various types of nuclear radiation (NR) with substance, NR transport theory and physical- mathematical simulation of basic problems of nuclear geophysics (NG) are considered. General classification of NG methods according to the type of the detected radiation with a more detailed division according to the physical essence of the interaction process employed is given. Direct NG problems are related to the study of space- energy radiation distribution in substance under certain cross sections of elementary interaction processes, substance properties and specified geometric conditions. The theoretical solution of the direct problems is based on using mathematical models of radiation transport in specified media. The NG inverse problems consist in determining element composition and other medium properties by data of integral or spectral characteristics of NR fields measurements. The NR in the course of its transport in substance can experience dozens of elementary interaction processes, the predominance of this or that process depending on NR energy, medium properties and geometric measurement conditions. This explains a wide NG method diversity. The Monte Carlo method application in the NR transport theory and various methods of decreasing calculations labour input are considered [ru

  14. Gross features of nuclear interactions around 1015 eV through observation of gamma ray families

    International Nuclear Information System (INIS)

    Semba, Hiroshi

    1983-01-01

    A systematic analysis is made on the 106 γ-ray families with visible energy in the range of 100--300 TeV observed in the Chacaltaya emulsion chamber experiment. A new method called 'decascading' is introduced to pick up a cluster of γ-rays and electrons in a family, so that the cluster is an air cascade from one parent γ-ray. The application of 'decascading' method to the family data gives information on original γ-rays produced at the atmospheric nuclear interactions. The results are compared with expected ones from the simulation calculation on the base of H-quantum model, and with data from the target interactions at lower energy range (ΣE sub(γ)=20 --100 TeV). The conclusion is that the characteristics of nuclear interactions at the concerned family energy range (E 0 asymptotically equals 1,000 TeV) are in accordance with those at the target interaction range (E 0 asymptotically equals 100 TeV), with increased ratio of frequencies of a heavy fire-ball (SH-quantum) to a small and usual fire-ball (H-quantum). (author)

  15. Microorganisms in potential host rocks for geological disposal of nuclear waste and their interactions with radionuclides

    Energy Technology Data Exchange (ETDEWEB)

    Cherkouk, A.; Liebe, M.; Luetke, L.; Moll, H.; Stumpf, T. [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Inst. of Resource Ecology

    2015-07-01

    The long-term safety of nuclear waste in a deep geological repository is an important issue in our society. Microorganisms indigenous to potential host rocks are able to influence the oxidation state, speciation and therefore the mobility of radionuclides as well as gas generation or canister corrosion. Therefore, for the safety assessment of such a repository it is necessary to know which microorganisms are present in the potential host rocks (e.g. clay, salt) and if these microorganisms can influence the performance of a repository. Microbial diversity in potential host rocks for geological disposal of nuclear waste was analyzed by culture-independent molecular biological methods (e.g. 16S rRNA gene retrieval) as well as enrichment and isolation of indigenous microbes. Among other isolates, a Paenibacillus strain, as a representative of Firmicutes, was recovered in R2A media under anaerobic conditions from Opalinus clay from the Mont Terri in Switzerland. Accumulation experiments and potentiometric titrations showed a strong interaction of Paenibacillus sp. cells with U(VI) within a broad pH range (3-7). Additionally, the interactions of the halophilic archaeal strain Halobacterium noricense DSM 15987, a salt rock representative reference strain, with U(VI) at high ionic strength was investigated. After 48 h the cells were still alive at uranium concentrations up to 60 μM, which demonstrates that Halobacterium noricense can tolerate uranium concentrations up to this level. The formed uranium sorption species were examined with time-resolved laser-induced fluorescence spectroscopy (TRLFS). The results about the microbial communities present in potential host rocks for nuclear waste repositories and their interactions with radionuclides contribute to the safety assessment of a prospective nuclear waste repository.

  16. Microorganisms in potential host rocks for geological disposal of nuclear waste and their interactions with radionuclides

    International Nuclear Information System (INIS)

    Cherkouk, A.; Liebe, M.; Luetke, L.; Moll, H.; Stumpf, T.

    2015-01-01

    The long-term safety of nuclear waste in a deep geological repository is an important issue in our society. Microorganisms indigenous to potential host rocks are able to influence the oxidation state, speciation and therefore the mobility of radionuclides as well as gas generation or canister corrosion. Therefore, for the safety assessment of such a repository it is necessary to know which microorganisms are present in the potential host rocks (e.g. clay, salt) and if these microorganisms can influence the performance of a repository. Microbial diversity in potential host rocks for geological disposal of nuclear waste was analyzed by culture-independent molecular biological methods (e.g. 16S rRNA gene retrieval) as well as enrichment and isolation of indigenous microbes. Among other isolates, a Paenibacillus strain, as a representative of Firmicutes, was recovered in R2A media under anaerobic conditions from Opalinus clay from the Mont Terri in Switzerland. Accumulation experiments and potentiometric titrations showed a strong interaction of Paenibacillus sp. cells with U(VI) within a broad pH range (3-7). Additionally, the interactions of the halophilic archaeal strain Halobacterium noricense DSM 15987, a salt rock representative reference strain, with U(VI) at high ionic strength was investigated. After 48 h the cells were still alive at uranium concentrations up to 60 μM, which demonstrates that Halobacterium noricense can tolerate uranium concentrations up to this level. The formed uranium sorption species were examined with time-resolved laser-induced fluorescence spectroscopy (TRLFS). The results about the microbial communities present in potential host rocks for nuclear waste repositories and their interactions with radionuclides contribute to the safety assessment of a prospective nuclear waste repository.

  17. Bending-Twisting Motions and Main Interactions in Nucleoplasmin Nuclear Import.

    Directory of Open Access Journals (Sweden)

    Marcos Tadeu Geraldo

    Full Text Available Alpha solenoid proteins play a key role in regulating the classical nuclear import pathway, recognizing a target protein and transporting it into the nucleus. Importin-α (Impα is the solenoid responsible for cargo protein recognition, and it has been extensively studied by X-ray crystallography to understand the binding specificity. To comprehend the main motions of Impα and to extend the information about the critical interactions during carrier-cargo recognition, we surveyed different conformational states based on molecular dynamics (MD and normal mode (NM analyses. Our model of study was a crystallographic structure of Impα complexed with the classical nuclear localization sequence (cNLS from nucleoplasmin (Npl, which was submitted to multiple 100 ns of MD simulations. Representative conformations were selected for calculating the 87 lowest frequencies NMs of vibration, and a displacement approach was applied along each NM. Based on geometric criteria, using the radius of curvature and inter-repeat angles as the reference metrics, the main motions of Impα were described. Moreover, we determined the salt bridges, hydrogen bonds and hydrophobic interactions in the Impα-NplNLS interface. Our results show the bending and twisting motions participating in the recognition of nuclear proteins, allowing the accommodation and adjustment of a classical bipartite NLS sequence. The essential contacts for the nuclear import were also described and were mostly in agreement with previous studies, suggesting that the residues in the cNLS linker region establish important contacts with Impα adjusting the cNLS backbone. The MD simulations combined with NM analysis can be applied to the Impα-NLS system to help understand interactions between Impα and cNLSs and the analysis of non-classic NLSs.

  18. Nuclear import of transcription factor BR-C is mediated by its interaction with RACK1.

    Science.gov (United States)

    Cheng, Daojun; Qian, Wenliang; Wang, Yonghu; Meng, Meng; Wei, Ling; Li, Zhiqing; Kang, Lixia; Peng, Jian; Xia, Qingyou

    2014-01-01

    The transcription factor Broad Complex (BR-C) is an early ecdysone response gene in insects and contains two types of domains: two zinc finger domains for the activation of gene transcription and a Bric-a-brac/Tramtrack/Broad complex (BTB) domain for protein-protein interaction. Although the mechanism of zinc finger-mediated gene transcription is well studied, the partners interacting with the BTB domain of BR-C has not been elucidated until now. Here, we performed a yeast two-hybrid screen using the BTB domain of silkworm BR-C as bait and identified the receptor for activated C-kinase 1 (RACK1), a scaffolding/anchoring protein, as the novel partner capable of interacting with BR-C. The interaction between BR-C and RACK1 was further confirmed by far-western blotting and pull-down assays. Importantly, the disruption of this interaction, via RNAi against the endogenous RACK1 gene or deletion of the BTB domain, abolished the nuclear import of BR-C in BmN4 cells. In addition, RNAi against the endogenous PKC gene as well as phosphorylation-deficient mutation of the predicted PKC phosphorylation sites at either Ser373 or Thr406 in BR-C phenocopied RACK1 RNAi and altered the nuclear localization of BR-C. However, when BTB domain was deleted, phosphorylation mimics of either Ser373 or Thr406 had no effect on the nuclear import of BR-C. Moreover, mutating the PKC phosphorylation sites at Ser373 and Thr406 or deleting the BTB domain significantly decreased the transcriptional activation of a BR-C target gene. Given that RACK1 is necessary for recruiting PKC to close and phosphorylate target proteins, we suggest that the PKC-mediated phosphorylation and nuclear import of BR-C is determined by its interaction with RACK1. This novel finding will be helpful for further deciphering the mechanism underlying the role of BR-C proteins during insect development.

  19. Nuclear import of transcription factor BR-C is mediated by its interaction with RACK1.

    Directory of Open Access Journals (Sweden)

    Daojun Cheng

    Full Text Available The transcription factor Broad Complex (BR-C is an early ecdysone response gene in insects and contains two types of domains: two zinc finger domains for the activation of gene transcription and a Bric-a-brac/Tramtrack/Broad complex (BTB domain for protein-protein interaction. Although the mechanism of zinc finger-mediated gene transcription is well studied, the partners interacting with the BTB domain of BR-C has not been elucidated until now. Here, we performed a yeast two-hybrid screen using the BTB domain of silkworm BR-C as bait and identified the receptor for activated C-kinase 1 (RACK1, a scaffolding/anchoring protein, as the novel partner capable of interacting with BR-C. The interaction between BR-C and RACK1 was further confirmed by far-western blotting and pull-down assays. Importantly, the disruption of this interaction, via RNAi against the endogenous RACK1 gene or deletion of the BTB domain, abolished the nuclear import of BR-C in BmN4 cells. In addition, RNAi against the endogenous PKC gene as well as phosphorylation-deficient mutation of the predicted PKC phosphorylation sites at either Ser373 or Thr406 in BR-C phenocopied RACK1 RNAi and altered the nuclear localization of BR-C. However, when BTB domain was deleted, phosphorylation mimics of either Ser373 or Thr406 had no effect on the nuclear import of BR-C. Moreover, mutating the PKC phosphorylation sites at Ser373 and Thr406 or deleting the BTB domain significantly decreased the transcriptional activation of a BR-C target gene. Given that RACK1 is necessary for recruiting PKC to close and phosphorylate target proteins, we suggest that the PKC-mediated phosphorylation and nuclear import of BR-C is determined by its interaction with RACK1. This novel finding will be helpful for further deciphering the mechanism underlying the role of BR-C proteins during insect development.

  20. Direct Measurement of Nuclear Dependence of Charged Current Quasielasticlike Neutrino Interactions Using MINERvA

    Science.gov (United States)

    Betancourt, M.; Ghosh, A.; Walton, T.; Altinok, O.; Bellantoni, L.; Bercellie, A.; Bodek, A.; Bravar, A.; Cai, T.; Martinez Caicedo, D. A.; Carneiro, M. F.; Dytman, S. A.; Díaz, G. A.; Felix, J.; Fields, L.; Fine, R.; Galindo, R.; Gallagher, H.; Ghosh, A.; Golan, T.; Gran, R.; Harris, D. A.; Higuera, A.; Hurtado, K.; Kiveni, M.; Kleykamp, J.; Le, T.; Maher, E.; Manly, S.; Mann, W. A.; Marshall, C. M.; McFarland, K. S.; McGivern, C. L.; McGowan, A. M.; Messerly, B.; Miller, J.; Mislivec, A.; Morfín, J. G.; Mousseau, J.; Naples, D.; Nelson, J. K.; Norrick, A.; Nuruzzaman, Patrick, C. E.; Perdue, G. N.; Ramírez, M. A.; Ren, L.; Rimal, D.; Rodrigues, P. A.; Ruterbories, D.; Schellman, H.; Sobczyk, J. T.; Solano Salinas, C. J.; Sánchez Falero, S.; Valencia, E.; Wolcott, J.; Wospakrik, M.; Yaeggy, B.; Minerva Collaboration

    2017-08-01

    Charged-current νμ interactions on carbon, iron, and lead with a final state hadronic system of one or more protons with zero mesons are used to investigate the influence of the nuclear environment on quasielasticlike interactions. The transferred four-momentum squared to the target nucleus, Q2, is reconstructed based on the kinematics of the leading proton, and differential cross sections versus Q2 and the cross-section ratios of iron, lead, and carbon to scintillator are measured for the first time in a single experiment. The measurements show a dependence on the atomic number. While the quasielasticlike scattering on carbon is compatible with predictions, the trends exhibited by scattering on iron and lead favor a prediction with intranuclear rescattering of hadrons accounted for by a conventional particle cascade treatment. These measurements help discriminate between different models of both initial state nucleons and final state interactions used in the neutrino oscillation experiments.

  1. Assessment of soil/structure interaction analysis procedures for nuclear power plant structures

    International Nuclear Information System (INIS)

    Young, G.A.; Wei, B.C.

    1977-01-01

    The paper presents an assessment of two state-of-the-art soil/structure interaction analysis procedures that are frequently used to provide seismic analyses of nuclear power plant structures. The advantages of large three-dimensional, elastic, discrete mass models and two-dimensional finite element models are compared. The discrete mass models can provide three-dimensional response capability with economical computer costs but only fair soil/structure interaction representation. The two-dimensional finite element models provide good soil/structure interaction representation, but cannot provide out-of-plane response. Three-dimensional finite element models would provide the most informative and complete analyses. For this model, computer costs would be much greater, but modeling costs would be approximately the same as those required for three-dimensional discrete mass models

  2. Detecting Structural Damage of Nuclear Power Plant by Interactive Data Mining Approach

    International Nuclear Information System (INIS)

    Yufei Shu

    2006-01-01

    This paper presents a nonlinear structural damage identification technique, based on an interactive data mining approach, which integrates a human cognitive model in a data mining loop. A mining control agent emulating human analysts is developed, which directly interacts with the data miner, analyzing and verifying the output of the data miner and controlling the data mining process. Additionally, an artificial neural network method, which is adopted as a core component of the proposed interactive data mining method, is evolved by adding a novelty detecting and retraining function for handling complicated nuclear power plant quake-proof data. Plant quake-proof testing data has been applied to the system to show the validation of the proposed method. (author)

  3. Equations of the quasiparticle-phonon nuclear model with effective finite-rank separable interactions

    International Nuclear Information System (INIS)

    Solov'ev, V.G.

    1989-01-01

    Basic equations are derived for the quasiparticle-phonon nuclear model for the finite-rank separable isoscalar and isovector multipole and spin-multipole and isovector tensor particle-hole and particle-particle interactions between quasiparticles. For even-even spherical nuclei it is shown that in the calculation of single-phonon states in the random phase approximation a significant complication arises due to the finite rank n max >1 of separable interactions. Taking into account separable interactions with n max >1 does not lead to significant difficulties in the calculation of fragmentation of quasiparticle and collective states. It is asserted that the model can be used as a basis for calculations of many characteristics of complex nuclei

  4. Effects of isospin and momentum-dependent interactions on thermal properties of nuclear matter

    International Nuclear Information System (INIS)

    Xu Jun; Ma Hongru; Chen Liewen; Li Baoan

    2009-01-01

    In this article, three models with different isospin and momentum dependence are used to study the thermodynamical properties of asymmetric nuclear matter. They are isospin and momentum-dependent MDI interaction constrained by the isospin diffusion data of heavy ion collision, the momentum-independent MID interaction and the isoscalar momentum-dependent eMDYI interaction. Temperature effects of symmetry energy, mechanical and chemical instability and liquid-gas phase transition are analyzed. It is found that for MDI model the temperature effects of the symmetry energy attribute from both the kinetic and potential energy, while only potential part contributes to the decreasing of the symmetry energy for MID and eMDYI models. We also find that the mechanical instability, chemical instability and liquid-gas phase transition are all sensitive to the isospin and momentum dependence and the density dependence of the symmetry energy. (authors)

  5. Coordinated rates of evolution between interacting plastid and nuclear genes in Geraniaceae.

    Science.gov (United States)

    Zhang, Jin; Ruhlman, Tracey A; Sabir, Jamal; Blazier, J Chris; Jansen, Robert K

    2015-03-01

    Although gene coevolution has been widely observed within individuals and between different organisms, rarely has this phenomenon been investigated within a phylogenetic framework. The Geraniaceae is an attractive system in which to study plastid-nuclear genome coevolution due to the highly elevated evolutionary rates in plastid genomes. In plants, the plastid-encoded RNA polymerase (PEP) is a protein complex composed of subunits encoded by both plastid (rpoA, rpoB, rpoC1, and rpoC2) and nuclear genes (sig1-6). We used transcriptome and genomic data for 27 species of Geraniales in a systematic evaluation of coevolution between genes encoding subunits of the PEP holoenzyme. We detected strong correlations of dN (nonsynonymous substitutions) but not dS (synonymous substitutions) within rpoB/sig1 and rpoC2/sig2, but not for other plastid/nuclear gene pairs, and identified the correlation of dN/dS ratio between rpoB/C1/C2 and sig1/5/6, rpoC1/C2 and sig2, and rpoB/C2 and sig3 genes. Correlated rates between interacting plastid and nuclear sequences across the Geraniales could result from plastid-nuclear genome coevolution. Analyses of coevolved amino acid positions suggest that structurally mediated coevolution is not the major driver of plastid-nuclear coevolution. The detection of strong correlation of evolutionary rates between SIG and RNAP genes suggests a plausible explanation for plastome-genome incompatibility in Geraniaceae. © 2015 American Society of Plant Biologists. All rights reserved.

  6. Coulomb interaction in atomic and nuclear physics: Inner-Shell excitation, Coulomb dissociation of nuclei, and nuclear polarizability in electronic atoms

    International Nuclear Information System (INIS)

    Hoffmann, B.

    1984-07-01

    In three chapters different physical situations are described which have commonly the Coulomb interaction as driving force. The first two chapters study the Coulomb interactions in connection with the excitation of inner electron shells and the Coulomb excitation of nuclei in first order. In the third part on effect ofthe Coulomb interaction between electronic shell and nucleus is treated in second order (nuclear polarization), and its effect on the isotopic and isomeric shift is studied. (orig./HSI) [de

  7. An operator training simulator based on interactive virtual teleoperation: nuclear facilities maintenance applications

    International Nuclear Information System (INIS)

    Kim, Ki Ho; Kim, Seung Ho

    1997-01-01

    Remote manipulation in nuclear hazardous environment is very often complex and difficult to operate and requires excessively careful preparation. Remote slave manipulators for unstructured work are manually controlled by a human operator. Small errors made by the operator via the master manipulator during operation can cause the slave to be surffered from excessive forces and result in considerable damages to the slave iteself and its environment. In this paper, we present a prototype of an operator training simulator for use in nuclear facilities maintenance applications, as part of the ongoing Nuclear Robotics Development Program at Korea Atomic Energy Research Institute (KAERI). The operator training simulator provides a means by which, in virtual task simulation, the operator can try out and train for expected remote tasks that the real slave manipulator will perform in advance. The operator interacts with both the virtual slave and task environment through the real master. Virtual interaction force feedback is provided to the operator. We also describe a man-in-the loop control scheme to realize bilateral force reflection in virtual teleoperation

  8. Studies of nuclear matter under extreme conditions: Heavy-ion interactions at ultra-relativistic energies

    Energy Technology Data Exchange (ETDEWEB)

    Nystrand, J

    1996-10-01

    The charged particle production in ultra-relativistic nucleus-nucleus collisions in the energy range 4-200 A GeV has been studied. Two different experimental techniques have been utilized: nuclear emulsions and multi-step avalanche chambers. The performance of the chambers in the experiment as well as the analysis of the chamber data are described in the thesis. The reconstructed particle momenta have been used to study transverse momentum distribution of negatively charged particles, and to perform intensity interferometry analyses in order to determine the source size and study the time-evolution of the interactions. Multiplicity and pseudorapidity distributions of singly charged particles obtained from interactions in nuclear emulsion have been studied. Simulations have been performed with various Monte-Carlo models, and particularly the effects of the hadronic rescattering have been studied. The results of the analysis have illustrated the great importance of the nuclear geometry in ultra-relativistic nucleus-nucleus collisions. Based on gaussian parametrizations a method of predicting the pseudorapidity distributions in systems of different sizes and at different energies has been developed. Furthermore, the multiplicity and angular distributions of slow, target associated particles have been analyzed. 99 refs, 19 figs.

  9. Studies of nuclear matter under extreme conditions: Heavy-ion interactions at ultra-relativistic energies

    International Nuclear Information System (INIS)

    Nystrand, J.

    1996-10-01

    The charged particle production in ultra-relativistic nucleus-nucleus collisions in the energy range 4-200 A GeV has been studied. Two different experimental techniques have been utilized: nuclear emulsions and multi-step avalanche chambers. The performance of the chambers in the experiment as well as the analysis of the chamber data are described in the thesis. The reconstructed particle momenta have been used to study transverse momentum distribution of negatively charged particles, and to perform intensity interferometry analyses in order to determine the source size and study the time-evolution of the interactions. Multiplicity and pseudorapidity distributions of singly charged particles obtained from interactions in nuclear emulsion have been studied. Simulations have been performed with various Monte-Carlo models, and particularly the effects of the hadronic rescattering have been studied. The results of the analysis have illustrated the great importance of the nuclear geometry in ultra-relativistic nucleus-nucleus collisions. Based on gaussian parametrizations a method of predicting the pseudorapidity distributions in systems of different sizes and at different energies has been developed. Furthermore, the multiplicity and angular distributions of slow, target associated particles have been analyzed. 99 refs, 19 figs

  10. Theoretical aspects of electroweak and other interactions in medium energy nuclear physics. Interim project report, January 17, 1984

    International Nuclear Information System (INIS)

    Mukhopadhyay, N.C.

    1984-01-01

    Progress is reported on the search for new particles in the nuclear and atomic processes and the theory of electroweak interactions in nuclei and exotic atoms. New particles under consideration are axions and scalons

  11. Interaction of DNA/nuclear protein/polycation and the terplexes for gene delivery

    Energy Technology Data Exchange (ETDEWEB)

    Shen Yuan; Pan Shirong; Feng Min; Wen Yuting; Deng Jingjing; Luo Xin; Wu Chuanbin [School of Pharmaceutical Sciences, Sun Yat-sen University, Zhongshan II Road 74, Guangzhou 510080 (China); Peng Hui, E-mail: fengmin@mail.sysu.edu.cn [School of Zhongshan Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080 (China)

    2010-01-29

    Nuclear transport of exogenous DNA is a major barrier to nonviral gene delivery that needs to be addressed in the design of new vectors. In this study, we prepared pDNA/HMGB1/PEG-PEI terplexes to promote nuclear import. HMGB1 in the terplexes was used to assist the transportation of pDNA into the nucleus of cells, since it contained nuclear localization signal (NLS); PEG chains were introduced to stabilize pDNA/vector terplexes and reduce the cytotoxicity. HMGB1/PEG-PEI combined vectors have been investigated specifically for their structure interaction by atomic force microscopy and circular dichroic spectroscopy. The results demonstrated that the HMGB1 molecule could bind with the pDNA chains, but not condense pDNA well. The PEG-PEI further compacted pDNA/HMGB1 complexes into nanosized spherical terplexes. The pDNA delivered by HMGB1/PEG-PEI combined vectors was significantly accumulated in the nucleus of cells, as observed by confocal laser scanning microscopy. The percentage of GFP-transfected cells and VEGF protein expression level induced by HMGB1/PEG-PEI were 2.6-4.9-fold and 1.4-2.8-fold higher, respectively, than that of a common cationic polymer PEI 25 kDa. Therefore, the HMGB1/PEG-PEI combined vector could be used as a versatile vector for promoting exogenous DNA nuclear localization, thereby enhancing its expression.

  12. Interactions between the nuclear matrix and an enhancer of the tryptophan oxygenase gene

    Energy Technology Data Exchange (ETDEWEB)

    Kaneoka, Hidenori [Department of Biotechnology, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603 (Japan); Miyake, Katsuhide, E-mail: miyake@nubio.nagoya-u.ac.jp [Department of Biotechnology, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603 (Japan); Iijima, Shinji [Department of Biotechnology, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603 (Japan)

    2009-10-02

    The gene for tryptophan oxygenase (TO) is expressed in adult hepatocytes in a tissue- and differentiation-specific manner. The TO promoter has two glucocorticoid-responsive elements (GREs), and its expression is regulated by glucocorticoid hormone in the liver. We found a novel GRE in close proximity to a scaffold/matrix attachment region (S/MAR) that was located around -8.5 kb from the transcriptional start site of the TO gene by electrophoretic mobility shift and chromatin immunoprecipitation (ChIP) assays. A combination of nuclear fractionation and quantitative PCR analysis showed that the S/MAR was tethered to the nuclear matrix in both fetal and adult hepatocytes. ChIP assay showed that, in adult hepatocytes, the S/MAR-GRE and the promoter proximal regions interacted with lamin and heterogeneous nuclear ribonucleoprotein U in a dexamethasone dependent manner, but this was not the case in fetal cells, suggesting that developmental stage-specific expression of the TO gene might rely on the binding of the enhancer (the -8.5 kb S/MAR-GRE) and the promoter to the inner nuclear matrix.

  13. 3D virtual facilities with interactive instructions for nuclear education and training

    International Nuclear Information System (INIS)

    Satoh, Yoshinori; Li, Ye; Zhu, Yuefeng; Rizwan-uddin

    2015-01-01

    Efficient and effective education and training of nuclear engineering students and future operators are critical for the safe operation and maintenance of nuclear power plants. Students and future operators used to receive some of the education and training at university laboratories and research reactors. With many university research reactors now shutdown, both students and future operators are deprived of this valuable training source. With an eye toward this need and to take advantage of recent developments in human machine interface technologies, we have focused on the development of 3D virtual laboratories for nuclear engineering education and training as well as to conduct virtual experiments. These virtual laboratories are expected to supplement currently available resources and education and training experiences. Resent focus is on adding interactivity and physics model to allow trainees to conduct virtual experiments. This paper reports some recent extensions to our virtual nuclear education laboratory and research reactor laboratory. These include head mounted display as well as hand tracking devices for virtual operations. (author)

  14. Interactions between the nuclear matrix and an enhancer of the tryptophan oxygenase gene

    International Nuclear Information System (INIS)

    Kaneoka, Hidenori; Miyake, Katsuhide; Iijima, Shinji

    2009-01-01

    The gene for tryptophan oxygenase (TO) is expressed in adult hepatocytes in a tissue- and differentiation-specific manner. The TO promoter has two glucocorticoid-responsive elements (GREs), and its expression is regulated by glucocorticoid hormone in the liver. We found a novel GRE in close proximity to a scaffold/matrix attachment region (S/MAR) that was located around -8.5 kb from the transcriptional start site of the TO gene by electrophoretic mobility shift and chromatin immunoprecipitation (ChIP) assays. A combination of nuclear fractionation and quantitative PCR analysis showed that the S/MAR was tethered to the nuclear matrix in both fetal and adult hepatocytes. ChIP assay showed that, in adult hepatocytes, the S/MAR-GRE and the promoter proximal regions interacted with lamin and heterogeneous nuclear ribonucleoprotein U in a dexamethasone dependent manner, but this was not the case in fetal cells, suggesting that developmental stage-specific expression of the TO gene might rely on the binding of the enhancer (the -8.5 kb S/MAR-GRE) and the promoter to the inner nuclear matrix.

  15. Nucleosome–nucleosome interactions via histone tails and linker DNA regulate nuclear rigidity

    Science.gov (United States)

    Shimamoto, Yuta; Tamura, Sachiko; Masumoto, Hiroshi; Maeshima, Kazuhiro

    2017-01-01

    Cells, as well as the nuclei inside them, experience significant mechanical stress in diverse biological processes, including contraction, migration, and adhesion. The structural stability of nuclei must therefore be maintained in order to protect genome integrity. Despite extensive knowledge on nuclear architecture and components, however, the underlying physical and molecular mechanisms remain largely unknown. We address this by subjecting isolated human cell nuclei to microneedle-based quantitative micromanipulation with a series of biochemical perturbations of the chromatin. We find that the mechanical rigidity of nuclei depends on the continuity of the nucleosomal fiber and interactions between nucleosomes. Disrupting these chromatin features by varying cation concentration, acetylating histone tails, or digesting linker DNA results in loss of nuclear rigidity. In contrast, the levels of key chromatin assembly factors, including cohesin, condensin II, and CTCF, and a major nuclear envelope protein, lamin, are unaffected. Together with in situ evidence using living cells and a simple mechanical model, our findings reveal a chromatin-based regulation of the nuclear mechanical response and provide insight into the significance of local and global chromatin structures, such as those associated with interdigitated or melted nucleosomal fibers. PMID:28428255

  16. Constraints on T-odd and P-even hadronic interactions from nucleon, nuclear, and atomic electric dipole moments

    International Nuclear Information System (INIS)

    Haxton, W.C.; Hoering, A.; Musolf, M.J.; Old Dominion Univ., Norfolk, VA

    1994-01-01

    We deduce constraints on time-reversal-noninvariant (TRNI), parity-conserving (PC) hadronic interactions from nucleon, nuclear, and atomic electric dipole moment (edm) limits. Such interactions generate edm's through weak radiative corrections. We consider long-ranged mechanisms, i.e., those mediated by meson exchanges in contrast to short-range two-loop mechanisms. We find that the ratio of typical TRNI. PC nuclear matrix elements to those of the strong interaction are approx-lt 10 -5 , a limit about two orders of magnitude more stringent than those from direct detailed balance studies of such interactions

  17. Problems of interaction between water and fuel containing masses inside the object 'Shelter' of Chernobyl nuclear power plant

    International Nuclear Information System (INIS)

    Yukhnovs'kij, Yi.R.; Kobrin, O.Je.; Tokarchuk, M.V.; Tokarevs'kij, V.V.

    1997-01-01

    The main forms of the existence of nuclear fuel and major concomitant factors of nuclear and ecological danger of the object 'Shelter' are presented. The processes of interaction between water and fuel containing materials have been analysed on the basis of experimental data

  18. Nuclear interaction study around beam pipe region in the Tracker system at CMS with 13 TeV data

    CERN Document Server

    CMS Collaboration

    2015-01-01

    Analysis is presented to study the material in the Tracker system with nuclear interactions from proton-proton collisions recorded by the CMS experiment at the CERN LHC. The data correspond to an integrated luminosity of 7.3 pb$^{-1}$ at a centre-of-mass energy of 13 TeV collected at 3.8 Tesla magnetic field. With reconstructed nuclear interactions we observe the structure of the material, including beam pipe, in the Tracker system.

  19. Fuel-cladding interaction. Framatome CEA experiment on pencils preirradiated in nuclear power plants

    International Nuclear Information System (INIS)

    Atabek, Rosemarie; Vignesoult, Nicole

    1979-01-01

    The study of the fuel-cladding interaction is the subject of an important joint research programme between Framatome and the CEA. Tests are performed either on whole fuel rods, not exceeding two metres in length, from BR3 or the CAP (PRISCA experiment) or on fuel rods refabricated in hot cells from fuel rods of power reactors (FABRICE experiment). The first results reveal the two mechanical and chemical aspects of the interaction phenomenon: the permissible power surge of the fuel elements passes through a minimum for an integrated fast dose (E>1MeV) of around 1.5x10 21 n/cm 2 ; a study made with the electronic microprobe and the scanning microscope shows that the Te, I and Cs fission products are the corrosive agents of the cladding [fr

  20. A physical model describing the interaction of nuclear transport receptors with FG nucleoporin domain assemblies.

    Science.gov (United States)

    Zahn, Raphael; Osmanović, Dino; Ehret, Severin; Araya Callis, Carolina; Frey, Steffen; Stewart, Murray; You, Changjiang; Görlich, Dirk; Hoogenboom, Bart W; Richter, Ralf P

    2016-04-08

    The permeability barrier of nuclear pore complexes (NPCs) controls bulk nucleocytoplasmic exchange. It consists of nucleoporin domains rich in phenylalanine-glycine motifs (FG domains). As a bottom-up nanoscale model for the permeability barrier, we have used planar films produced with three different end-grafted FG domains, and quantitatively analyzed the binding of two different nuclear transport receptors (NTRs), NTF2 and Importin β, together with the concomitant film thickness changes. NTR binding caused only moderate changes in film thickness; the binding isotherms showed negative cooperativity and could all be mapped onto a single master curve. This universal NTR binding behavior - a key element for the transport selectivity of the NPC - was quantitatively reproduced by a physical model that treats FG domains as regular, flexible polymers, and NTRs as spherical colloids with a homogeneous surface, ignoring the detailed arrangement of interaction sites along FG domains and on the NTR surface.

  1. Charmonium production and nuclear absorption in p-A interactions at 450 GeV

    CERN Document Server

    Alessandro, B; Arnaldi, R; Atayan, M; Baglin, C; Baldit, A; Beolè, S; Boldea, V; Bordalo, P; Borenstein, S R; Borges, G; Bussière, A; Capelli, L; Castanier, C; Castor, J I; Chaurand, B; Cheynis, B; Chiavassa, E; Cicalò, C; Claudino, T; Comets, M P; Constans, N; Constantinescu, S; Cortese, P; Cruz, J; De Falco, A; De Marco, N; Dellacasa, G; Devaux, A; Dita, S; Drapier, O; Espagnon, B; Fargeix, J; Force, P; Gallio, M; Gerschel, C; Giubellino, P; Golubeva, M B; Gonin, M; Grigorian, A A; Grigorian, S; Grossiord, J Y; Guber, F F; Guichard, A; Gulkanian, H R; Idzik, M; Jouan, D; Karavitcheva, T L; Kluberg, L; Kurepin, A B; Le, Y; Le Bornec, Y; Lourenço, C; Macciotta, P; MacCormick, M; Marzari-Chiesa, A; Masera, M; Masoni, A; Monteno, M; Musso, A; Petiau, P; Piccotti, A; Pizzi, J R; Prino, F; Puddu, G; Quintans, C; Ramello, L; Ramos, S; Rato-Mendes, P; Riccati, L; Romana, A; Santos, H; Saturnini, P; Scomparin, E; Serci, S; Shahoyan, R; Sigaudo, F; Sitta, M; Sonderegger, P; Tarrago, X; Topilskaya, N S; Usai, G L; Vercellin, Ermanno; Villatte, L; Willis, N

    2004-01-01

    The production of J/psi and psi' charmonium states in proton-nucleus interactions has been investigated by the NA50 experiment, at the CERN SPS. High statistics data sets were collected with collisions induced by 450GeV protons incident on Be, Al, Cu, Ag and W targets. The J/psi and psi' production cross-sections have been determined for each p-A system and their dependences on the nucleus size have been studied, leading to the so-called normal nuclear absorption. Comparing the two patterns we see that the nuclear absorption is stronger for the psi' than for the J/psi. Given the high statistics of the data samples, the x_F (or rapidity) differential cross-sections of the J/psi and psi' states have also been studied, for each of the target nuclei.

  2. Dynamic interaction of components, structure, and foundation of nuclear power facilities

    International Nuclear Information System (INIS)

    Pajuhesh, J.; Hadjian, A.H.

    1977-01-01

    A solution is formulated for the dynamic analysis of structures and components with different stiffness and damping characteristics, including the consideration of soil-structure interaction effects. Composite structures are often analysed approximately, in particular with regards to damping. For example, the reactor and other equipment in nuclear power plant structures are often analysed by assuming them uncoupled from the supporting structures. To achieve a better accuracy, the coupled system is hereby analysed as a composite component-structure-soil system. To demonstrate the assembly technique, two examples are considered: (a) a steel structure sitting on a concrete stem and linked by a steel bridge to another concrete structure, and (b) an actual model of a nuclear power plant containment structure. (Auth.)

  3. Seismic response of nuclear reactors in layered liquefiable soil deposits including nonlinear soil-structure interaction

    International Nuclear Information System (INIS)

    Zaman, M.; Mamoon, S.M.

    1989-01-01

    Analysis of seismic response of structures located at a site with potential for soil liquefaction has drawn attention of many researchers. The topic is particularly important in the design of critical facilities like nuclear reactors and defense installations. This paper presents the results of a study involving evaluation of coupled seismic response of structures (model nuclear reactors) and characteristics of soil liquefaction at a site. The analysis procedure employed is based on the nonlinear finite element (FE) technique and accounts for the interaction effects due to a neighboring structure. Emphasis is given to the following features: prediction of spatial and temporal variation of pore water pressure; identification of the on-set of liquefaction based on the effective stress approach, and tracing the propagation of the liquefied zones with time and resulting response of the structures

  4. Relativistic effects in the intermolecular interaction-induced nuclear magnetic resonance parameters of xenon dimer

    DEFF Research Database (Denmark)

    Hanni, Matti; Lantto, Perttu; Ilias, Miroslav

    2007-01-01

    Relativistic effects on the 129Xe nuclear magnetic resonance shielding and 131Xe nuclear quadrupole coupling (NQC) tensors are examined in the weakly bound Xe2 system at different levels of theory including the relativistic four-component Dirac-Hartree-Fock (DHF) method. The intermolecular...... interaction-induced binary chemical shift d, the anisotropy of the shielding tensor ?s, and the NQC constant along the internuclear axis ?ll are calculated as a function of the internuclear distance. DHF shielding calculations are carried out using gauge-including atomic orbitals. For comparison, the full...... is obtained for d and ?s in Xe2. For these properties, the currently most complete theoretical description is obtained by a piecewise approximation where the uncorrelated relativistic DHF results obtained close to the basis-set limit are corrected, on the one hand, for NR correlation effects and, on the other...

  5. Interaction of nucleosome assembly proteins abolishes nuclear localization of DGKζ by attenuating its association with importins

    International Nuclear Information System (INIS)

    Okada, Masashi; Hozumi, Yasukazu; Ichimura, Tohru; Tanaka, Toshiaki; Hasegawa, Hiroshi; Yamamoto, Masakazu; Takahashi, Nobuya; Iseki, Ken; Yagisawa, Hitoshi; Shinkawa, Takashi; Isobe, Toshiaki; Goto, Kaoru

    2011-01-01

    Diacylglycerol kinase (DGK) is involved in the regulation of lipid-mediated signal transduction through the metabolism of a second messenger diacylglycerol. Of the DGK family, DGKζ, which contains a nuclear localization signal, localizes mainly to the nucleus but translocates to the cytoplasm under pathological conditions. However, the detailed mechanism of translocation and its functional significance remain unclear. To elucidate these issues, we used a proteomic approach to search for protein targets that interact with DGKζ. Results show that nucleosome assembly protein (NAP) 1-like 1 (NAP1L1) and NAP1-like 4 (NAP1L4) are identified as novel DGKζ binding partners. NAP1Ls constitutively shuttle between the nucleus and the cytoplasm in transfected HEK293 cells. The molecular interaction of DGKζ and NAP1Ls prohibits nuclear import of DGKζ because binding of NAP1Ls to DGKζ blocks import carrier proteins, Qip1 and NPI1, to interact with DGKζ, leading to cytoplasmic tethering of DGKζ. In addition, overexpression of NAP1Ls exerts a protective effect against doxorubicin-induced cytotoxicity. These findings suggest that NAP1Ls are involved in a novel molecular basis for the regulation of nucleocytoplasmic shuttling of DGKζ and provide a clue to examine functional significance of its translocation under pathological conditions.

  6. Sinup, a novel Siaz-interacting nuclear protein, modulates neural plate formation in the zebrafish embryos

    International Nuclear Information System (INIS)

    Ro, Hyunju; Won, Minho; Lee, Su-Ui; Kim, Kyoon E.; Huh, Tae-Lin; Kim, Cheol-Hee; Rhee, Myungchull

    2005-01-01

    Siah, the vertebrate homologue of the Drosophila seven in absentia (sina) gene, is well conserved from Drosophila to mammal and involved in ubiquitination and proteasome-dependent degradation of various target proteins. To identify cellular proteins interacting with Siah, we screened a zebrafish cDNA library with zebrafish Siah (Siaz) as bait in a yeast two-hybrid assay. We identified a cDNA encoding a novel protein composed of 145 amino acids and termed it as Sinup (Siaz-interacting-nuclear-protein). Sinup is a novel nuclear protein that binds to the highly conserved C-terminal protein-interacting domain of Siaz both in vivo and in vitro. During development, sinup transcripts are abundant from the one-cell stage to the early blastula and then markedly diminished, suggesting sinup largely exists as maternal transcripts. sinup overexpression induced lateral expansion of the neural plate and in consequence caused ectopic expression of otx-2 and hoxb1b during the late gastrula stage. In addition, the lateral/paraxial expression of wnt8 at the onset of gastrulation is suppressed by the forced expression of sinup while the expression levels of various dorso-ventral markers are unaffected. In contrast, interfering with sinup functions using sinup morpholino oligonucleotides gradually diminished the anterior neuroectoderm from the posterior region, and resulted in compete loss of hindbrain at the 3-somites stage. Our report suggests that sinup expression should be tightly regulated during early embryonic development for the proper neural plate formation

  7. Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization.

    Science.gov (United States)

    Liebsch, Filip; Aurousseau, Mark R P; Bethge, Tobias; McGuire, Hugo; Scolari, Silvia; Herrmann, Andreas; Blunck, Rikard; Bowie, Derek; Multhaup, Gerd

    2017-08-11

    The β-secretase (BACE1) initiates processing of the amyloid precursor protein (APP) into Aβ peptides, which have been implicated as central players in the pathology of Alzheimer disease. BACE1 has been described as a copper-binding protein and its oligomeric state as being monomeric, dimeric, and/or multimeric, but the native cellular stoichiometry has remained elusive. Here, by using single-molecule fluorescence and in vitro cross-linking experiments with photo-activatable unnatural amino acids, we show that full-length BACE1, independently of its subcellular localization, exists as trimers in human cells. We found that trimerization requires the BACE1 transmembrane sequences (TMSs) and cytoplasmic domains, with residues Ala 463 and Cys 466 buried within the trimer interface of the sulfur-rich core of the TMSs. Our 3D model predicts that the sulfur-rich core of the trimeric BACE1 TMS is accessible to metal ions, but copper ions did not trigger trimerization. The results of functional assays of endogenous BACE1 suggest that it has a role in intracellular copper compartmentalization by transferring cytosolic copper to intracellular compartments, while leaving the overall cellular copper concentration unaltered. Adding to existing physiological models, our results provide novel insight into the atypical interactions between copper and BACE1 and into its non-enzymatic activities. In conclusion, therapeutic Alzheimer disease prevention strategies aimed at decreasing BACE1 protein levels should be regarded with caution, because adverse effects in copper homeostasis may occur. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  8. Arabidopsis TCP Transcription Factors Interact with the SUMO Conjugating Machinery in Nuclear Foci

    Directory of Open Access Journals (Sweden)

    Magdalena J. Mazur

    2017-11-01

    Full Text Available In Arabidopsis more than 400 proteins have been identified as SUMO targets, both in vivo and in vitro. Among others, transcription factors (TFs are common targets for SUMO conjugation. Here we aimed to exhaustively screen for TFs that interact with the SUMO machinery using an arrayed yeast two-hybrid library containing more than 1,100 TFs. We identified 76 interactors that foremost interact with the SUMO conjugation enzyme SCE1 and/or the SUMO E3 ligase SIZ1. These interactors belong to various TF families, which control a wide range of processes in plant development and stress signaling. Amongst these interactors, the TCP family was overrepresented with several TCPs interacting with different proteins of the SUMO conjugation cycle. For a subset of these TCPs we confirmed that the catalytic site of SCE1 is essential for this interaction. In agreement, TCP1, TCP3, TCP8, TCP14, and TCP15 were readily SUMO modified in an E. coli sumoylation assay. Strikingly, these TCP-SCE1 interactions were found to redistribute these TCPs into nuclear foci/speckles, suggesting that these TCP foci represent sites for SUMO (conjugation activity.

  9. Study of various models of nuclear interaction potentials: nucleon-nucleus and nucleus-nucleus systems

    International Nuclear Information System (INIS)

    Ngo, H.

    1984-01-01

    Several models, performed within a mean field theory, are developed for the calculation of nucleon-nucleus interaction potentials. The first part of the thesis deals with the nucleon-nucleus average interaction. It is mainly devoted to the calculation of dynamical corrections to the Hartree-Fock approximation. Two approaches are used: a microscopic model performed in the framework of the nuclear structure approach and a semi-phenomenological one, based on the application of the dispersion relations to the empirical imaginary potential. Both models take into account finite size effects like collectivity or threshold effects which are important at low energy. The Green's function properties are used for both models. The second part of this work is devoted to the interaction potential between two heavy ions. This calculation, which is performed in the framework of the sudden approximation, uses the energy density formalism (Thomas-Fermi approximation). It has been extended to finite temperature. At T=0 the experimental fusion barriers of heavy systems are reproduced within 4%. Their temperature dependence is studied. The proximity scaling is checked and a universal function is obtained at T=0 and at finite temperature. It is found that the proximity theorem is well satisfied on the average. The dispersion around the mean behaviour increases with increasing temperature. At last, P+A* and α+A* interaction potentials are calculated within a double folding model using a schematic effective interaction [fr

  10. Interactive computer codes for education and training on nuclear safety and radioprotection

    International Nuclear Information System (INIS)

    Leszczynski, Francisco

    2008-01-01

    Two interactive computer codes for education and training on nuclear safety and radioprotection developed at RA6 Reactor Division-Bariloche Atomic Center-CNEA are presented on this paper. The first code named SIMREACT has been developed in order to simulate the control of a research nuclear reactor in real time with a simple but accurate approach. The code solves the equations of neutron punctual kinetics with time variable reactivity. Utilizing the timer of the computer and the controls of a PC keyboard, with an adequate graphic interface, a simulation in real time of the temporal behavior of a research reactor is obtained. The reactivity can be changed by means of the extraction or insertion of control rods. It was implemented also the simulation of automatic pilot and scram. The use of this code is focalized on practices of nuclear reactor control like start-up from the subcritical state with external source up to power to a desired level, change of power level, calibration of a control rod with different methods, and approach to critical condition by interpolation of the answer in function of reactivity. The second code named LICEN has been developed in order to help the studies of all the topics included in examination programs for obtaining licenses for research reactor operators and radioprotection officials. Using the PC mouse, with an adequate graphic interface, the student can gradually learn the topics related with general and special licenses. The general option includes nuclear reactor engineering, radioprotection, nuclear safety, documentation and normative. The specific option includes mandatory documentation, description of the installation and task on normal and emergency situations. For each of these topics there are sub-items with all the relevant information. The objective of this code is to joint in one electronic place a large amount of information which usually it is disseminated on difficult to find separated papers. (author)

  11. Nuclear γ-tubulin associates with nucleoli and interacts with tumor suppressor protein C53.

    Science.gov (United States)

    Hořejší, Barbora; Vinopal, Stanislav; Sládková, Vladimíra; Dráberová, Eduarda; Sulimenko, Vadym; Sulimenko, Tetyana; Vosecká, Věra; Philimonenko, Anatoly; Hozák, Pavel; Katsetos, Christos D; Dráber, Pavel

    2012-01-01

    γ-Tubulin is assumed to be a typical cytosolic protein necessary for nucleation of microtubules from microtubule organizing centers. Using immunolocalization and cell fractionation techniques in combination with siRNAi and expression of FLAG-tagged constructs, we have obtained evidence that γ-tubulin is also present in nucleoli of mammalian interphase cells of diverse cellular origins. Immunoelectron microscopy has revealed γ-tubulin localization outside fibrillar centers where transcription of ribosomal DNA takes place. γ-Tubulin was associated with nucleolar remnants after nuclear envelope breakdown and could be translocated to nucleoli during mitosis. Pretreatment of cells with leptomycin B did not affect the distribution of nuclear γ-tubulin, making it unlikely that rapid active transport via nuclear pores participates in the transport of γ-tubulin into the nucleus. This finding was confirmed by heterokaryon assay and time-lapse imaging of photoconvertible protein Dendra2 tagged to γ-tubulin. Immunoprecipitation from nuclear extracts combined with mass spectrometry revealed an association of γ-tubulin with tumor suppressor protein C53 located at multiple subcellular compartments including nucleoli. The notion of an interaction between γ-tubulin and C53 was corroborated by pull-down and co-immunoprecipitation experiments. Overexpression of γ-tubulin antagonized the inhibitory effect of C53 on DNA damage G(2) /M checkpoint activation. The combined results indicate that aside from its known role in microtubule nucleation, γ-tubulin may also have nuclear-specific function(s). Copyright © 2011 Wiley Periodicals, Inc.

  12. E-film - an interactive clinical teaching tool for nuclear medicine

    International Nuclear Information System (INIS)

    Zohar, T.; VanEvery, B.

    2002-01-01

    Full text: With the advent of technology the old fashioned film library used by our Nuclear Medicine staff has been updated and remodelled from 'hard copy learning' with film and light boxes to 'soft-copy learning' using standard PC hardware and software. The new model 'e-film' is a web browser based image viewer written in HTML. It incorporates interesting case studies with interactive questions and answers based on pathology. The easy-to-use design involves selecting a Nuclear Medicine scan e g bone scan, and then the pathology of interest e g osteomyelitis. Each pathology selected has a normal and a number of abnormal cases, which can be viewed as static planar and dynamic images or as movies. The text displayed with each case study is a question with an answer that can be revealed when ready. A general learning tip pertaining to the scan type or particular pathology can also be revealed on request. Many of the case studies incorporate images from other modalities such as CT or MRI for comparison with the Nuclear Medicine images. Pre- and post- treatment scans can also be viewed to assess outcome 'e film' allows staff to search in a specific area of Nuclear Medicine and then test themselves on their understanding of the scan and relevant pathologies. Standard web browsers on PC's allow department-wide user accessibility of e-film via an intranet configuration. In summary, e-film is a convenient, time efficient way of learning with the potential of unlimited data expansion. Copyright (2002) The Australian and New Zealand Society of Nuclear Medicine Inc

  13. Coupling of impedance functions to nuclear reactor building for soil-structure interaction analysis

    International Nuclear Information System (INIS)

    Danisch, R.; Delinic, K.; Trbojevic, V.M.

    1991-01-01

    Finite element model of a nuclear reactor building is coupled to complex soil impedance functions and soil-structure-interaction analysis is carried out in frequency domain. In the second type of analysis applied in this paper, soil impedance functions are used to evaluate equivalent soil springs and dashpots of soil. These are coupled to the structure model in order to carry out the time marching analysis. Three types of soil profiles are considered: hard, medium and soft. Results of two analyzes are compared on the same structural model. Equivalent soil springs and dashpots are determined using new method based on the least square approximation. (author)

  14. Novel nuclear-encoded proteins interacting with a plastid sigma factor, Sig1, in Arabidopsis thaliana.

    Science.gov (United States)

    Morikawa, Kazuya; Shiina, Takashi; Murakami, Shinya; Toyoshima, Yoshinori

    2002-03-13

    Sigma factor binding proteins are involved in modifying the promoter preferences of the RNA polymerase in bacteria. We found the nuclear encoded protein (SibI) that is transported into chloroplasts and interacts specifically with the region 4 of Sig1 in Arabidopsis. SibI and its homologue, T3K9.5 are novel proteins, which are not homologous to any protein of known function. The expression of sibI was tissue specific, light dependent, and developmentally timed. We suggest the transcriptional regulation by sigma factor binding proteins to function in the plastids of higher plant.

  15. Radiation factors and smoking interaction at lung cancer incidence for workers at a nuclear enterprise

    International Nuclear Information System (INIS)

    Tokarskaya, Z.B.; Khokhryakov, V.F.; Okladnikova, N.D.; Belyaeva, Z.D.; Zhuntova, G.V.

    1997-01-01

    It was shown on the basis of retrospective investigation of 500 workers at a nuclear enterprise (162 cases of lung cancer, 338 persons as matching control) that the interaction of external gamma-irradiation (> 2.0 Gy) and the body - burden of 239 Pu (> 9.3 kBq) at lung cancer is characterized as the multiplicative effect. Combined influence of smoking and radiation factors dependent on smoking index (SI): it changed from additive up to multiplicative and than to antagonistic with the increase of the smoking effect. The received results could be explained on the basis of a two - mutation model of radiation carcinogenesis

  16. Cosmic ray nuclear interactions and EAS-triggered families observed by the Chacaltaya hybrid experiment

    International Nuclear Information System (INIS)

    Aoki, H.; Honda, K.; Inoue, N.; Ishii, T.; Kawasumi, N.; Martinic, N.; Ochi, N.; Ohmori, N.; Ohsawa, A.; Tamada, M.; Ticona, R.

    2008-01-01

    Longitudinal and lateral characteristics of the families detected by emulsion chambers in the hybrid experiment with AS-array at Mt. Chacaltaya are studied in detail. Although many groups discuss about an increase of the heavy component in primary cosmic-rays beyond the knee region, it is shown that the observed characteristics of the families accompanied by large shower size, Ne>10 6 , can not be explained by an increase of heavy primaries alone. It is necessary to assume some changes of nuclear interaction in order to explain the observed characteristics of the air-showers accompanied by families

  17. Two-body tensor interactions in the nuclear matter response function

    International Nuclear Information System (INIS)

    Besprosvany, J.

    1997-01-01

    The inclusive scattering response of nuclear matter is studied in the regime of large momentum transfer q, and around the quasielastic peak. We review interaction corrections to free propagation as embodied in the impulse approximation. Calculations of the two-body and many-body corrections within an eikonal approach are presented. These use an approximated two-body density matrix which takes account of spin and isospin degrees of freedom. Both calculations give similar and sizable corrections at q = 550 MeV and reproduce data extrapolated from finite nuclei; this indicates the relevance of two-body tensor contributions in this regime. (Author)

  18. A revision of photon interaction data in the UKAEA nuclear data library

    International Nuclear Information System (INIS)

    Knipe, A.D.

    1975-10-01

    Photon interaction data in the UKAEA Nuclear Data Library have been updated and extended to cover all elements up to Atomic Number 94. Cross-sections for the photoelectric effect, Compton scattering, pair-production, and the total cross-section, are stored at 40 energy points in the range 0.01 MeV to 20 MeV. The angular distribution for Compton scattering is also included in the library. This report describes the derivation and accuracy of the data, and tabulates the cross-sections and angular distribution in the appendices. The preparation of multigroup cross-sections from the library's data is also discussed. (author)

  19. Measurements of interaction cross sections and nuclear radii of Li isotopes

    International Nuclear Information System (INIS)

    Tanihata, I.; Hamagaki, H.; Hashimoto, O.; Shida, Y.; Yoshikawa, N.; Sugimoto, K.; Yamakawa, O.; Kobayashi, T.; Takahashi, N.

    1985-08-01

    Interaction cross sections(σ sub(I)) for all known Li isotopes ( 6 Li - 11 Li) and 9 Be on targets Be, C, and Al have been measured at 790 MeV/nucleon. Nuclear radii(R sub(I)) of these isotopes have been deduced from the σ sub(I). The differences of radii among isobars( 6 He - 6 Li, 8 He - 8 Li, and 9 Li - 9 Be) have been found for the first time. A comparison of R sub(I) with the rms radii obtained from electron-scattering is presented. (author)

  20. Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles

    International Nuclear Information System (INIS)

    Lin, C.-L.; Leu, Steve; Lu, M.-C.; Ouyang Pin

    2004-01-01

    Pre-mRNA splicing takes place within a dynamic ribonucleoprotein particle called the spliceosome and occurs in an ordered pathway. Although it is known that spliceosome consists of five small nuclear RNAs and at least 50 proteins, little is known about how the interaction among the proteins changes during splicing. Here we identify that SR-cyp, a Moca family of nuclear cyclophilin, interacts and colocalizes with nuclear pinin (pnn), a SR-related protein involving in pre-mRNA splicing. Nuclear pnn interacts with SR-cyp via its C-terminal RS domain. Upon SR-cyp over-expression, however, the subnuclear distribution of nuclear pnn is altered, resulting in its redistribution from nuclear speckles to a diffuse nucleoplasmic form. The diffuse subnuclear distribution of nuclear pnn is not due to epitope masking, accelerated protein turnover or post-translational modification. Furthermore, we find that SR-cyp regulates the subnuclear distribution of other SR family proteins, including SC35 and SRm300, in a similar manner as it does on nuclear pnn. This result is significant because it suggests that SR-cyp plays a general role in modulating the distribution pattern of SR-like and SR proteins, similar to that of Clk (cdc2-like kinase)/STY on SR family splicing factors. SR-cyp might direct its effect via either alteration of protein folding/conformation or of protein-protein interaction and thus may add another control level of regulation of SR family proteins and modification of their functions

  1. Relativistic scalar-vector models of the N-N and N-nuclear interactions

    International Nuclear Information System (INIS)

    Green, A.E.S.

    1985-01-01

    This paper for the Proceedings of Conference an Anti-Nucleon and Nucleon-Nucleus Interactions summarizes work by the principal investigator and his collaborators on the nucleon-nucleon (N-N) and nucleon-nuclear (N-eta) interactions. It draws heavily on a paper presented at the Many Body Conference in Rome in 1972 but also includes a brief review of our phenomenological N-eta interaction studies. We first summarize our 48-49 generalized scalar-vector meson field theory model of the N-N interactions. This is followed by a brief description of our phenomenological work in the 50's on the N-eta interaction sponsored by the Atomic Energy Commission (the present DOE). This work finally led to strong velocity dependent potentials with spin orbit and isospin terms for shell and optical model applications. This is followed by a section on the Emergence of One-Boson Exchange Models describing developments in the 60's of quantitative generalized one boson exchange potentials (GOBEP) including our purely relativistic N-N analyses. Then follows a section on the application of this meson field model to the N-eta interaction, in particular to spherical closed shell nuclei. This work was sponsored by AFOSR but funding was halted with the Mansfield amendment. We conclude with a discussion of subsequent collateral work by former colleagues and by others who have converged upon scalar-vector relativistic models of N-N, antiN-N, N-eta and antiN-eta interactions and some lessons learned from this extended endeavor. 61 refs

  2. Norm of nuclear weapons non-use and deterrence: interaction of the conceptions in case of usa

    OpenAIRE

    Bladaitė, Neringa

    2016-01-01

    Norm of Nuclear Weapons Non-use and Deterrence: Interaction of the Conceptions in Case of USA The problem that is analyzed in this master thesis is formed according the paradox. Although, US is thought to be the county that maintains norm of non-use, in the practice US forms the strategy according nuclear deterrence. The object of this master thesis is nuclear weapons posture of US during the period of 2009-2015. The main aim of this thesis is to explore posture of US nuclear weapons use base...

  3. Los Alamos Nuclear Plant Analyzer: an interactive power-plant simulation program

    International Nuclear Information System (INIS)

    Steinke, R.; Booker, C.; Giguere, P.; Liles, D.R.; Mahaffy, J.H.; Turner, M.R.

    1984-01-01

    The Nuclear Plant Analyzer (NPA) is a computer-software interface for executing the TRAC or RELAP5 power-plant systems codes. The NPA is designed to use advanced supercomputers, long-distance data communications, and a remote workstation terminal with interactive computer graphics to analyze power-plant thermal-hydraulic behavior. The NPA interface simplifies the running of these codes through automated procedures and dialog interaction. User understanding of simulated-plant behavior is enhanced through graphics displays of calculational results. These results are displayed concurrently with the calculation. The user has the capability to override the plant's modeled control system with hardware-adjustment commands. This gives the NPA the utility of a simulator, and at the same time, the accuracy of an advanced, best-estimate, power-plant systems code for plant operation and safety analysis

  4. Team interaction skills evaluation criteria for nuclear power plant control room operators

    International Nuclear Information System (INIS)

    Montgomery, J.; Gaddy, C.; Toquam, J.

    1991-01-01

    This paper reports on previous research which has shown the value of good team interaction skills to group performance, yet little progress has been made in measuring such skills. Dimensions of team interaction skills developed in an earlier study were extensively revised and cast into a Behaviorally anchored Rating scales (BARS) and a Behavioral Frequency scale format. Rating data were collected using training instructors at a nuclear plant, who rated videotape scenarios of control room performance and later rated control room crews during requalification training. High levels of interrater agreement on both rating scales was, although the hypothesized factor structure did not emerge. Analysis of ratings of the videotapes using Cronbach's components of accuracy indicted that BARS ratings generally exhibited less error than did the Behavioral Frequency ratings. This paper discusses results in terms of both field and research implications

  5. Nuclear Plant Analyzer: an interactive TRAC/RELAP Power-Plant Simulation Program

    International Nuclear Information System (INIS)

    Steinke, R.; Booker, C.; Giguere, P.; Liles, D.; Mahaffy, J.; Turner, M.; Wiley, R.

    1984-01-01

    The Nuclear Plant Analyzer (NPA) is a computer-software interface for executing the TRAC or RELAP5 power-plant systems codes. The NPA is designed to use advanced supercomputers, long-distance data communications, and a remote workstation terminal with interactive computer graphics to analyze power-plant thermal-hydraulic behavior. The NPA interface simplifies the running of these codes through automated procedures and dialog interaction. User understanding of simulated-plant behavior is enhanced through graphics displays of calculational results. These results are displayed concurrently with the calculation. The user has the capability to override the plant's modeled control system with hardware adjustment commands. This gives the NPA the utility of a simulator, and at the same time, the accuracy of an advanced, best-estimate, power-plant systems code for plant operation and safety analysis

  6. Effective mass of a #betta#-particle in nuclear matter and OBE #betta#-n interactions

    International Nuclear Information System (INIS)

    Bando, Hiroharu; Nagata, Sinobu.

    1982-01-01

    The effective mass of a lambda particle (M sub( lambda )*) in nuclear matter is investigated within the framework of the lowest-order Brueckner theory by employing the Nijmegen OBE lambda -N interaction model D and F. The non-locality mass (M tilde sub( lamda )) and the energy mass (anti M sub( lambda )) are evaluated and discussed in the light of the characteristics of the two models. In comparison with the model D, the model F yields smaller anti M sub( lambda ) and larger anti M sub( lamb da ) reflecting the stronger Majorana exchange force and the stronger lambda N- sigma N coupling tensor force. Final results of M sub( lambda )*/M sub( lambda ) are 0.85 for D and 0.79 for F. In view of the effective lambda mass inferred from observed properties of the single particle potential for lambda , the model D interaction seems to be more adequate. (author)

  7. Generation of a command language for nuclear signal and image processing on the basis of a general interactive system

    International Nuclear Information System (INIS)

    Pretschner, D.P.; Pfeiffer, G.; Deutsches Elektronen-Sychnchrotron

    1981-01-01

    In the field of nuclear medicine, BASIC and FORTRAN are currently being favoured as higher-level programming languages for computer-aided signal processing, and most operating systems of so-called ''freely programmable analyzers'' in nuclear wards have compilers for this purpose. However, FORTRAN is not an interactive language and thus not suited for conversational computing as a man-machine interface. BASIC, on the other hand, although a useful starting language for beginners, is not sufficiently sophisticated for complex nuclear medicine problems involving detailed calculations. Integration of new methods of signal acquisition, processing and presentation into an existing system or generation of new systems is difficult in FORTRAN, BASIC or ASSEMBLER and can only be done by system specialists, not by nuclear physicians. This problem may be solved by suitable interactive systems that are easy to learn, flexible, transparent and user-friendly. An interactive system of this type, XDS, was developed in the course of a project on evaluation of radiological image sequences. An XDS-generated command processing system for signal and image processing in nuclear medicine is described. The system is characterized by interactive program development and execution, problem-relevant data types, a flexible procedure concept and an integrated system implementation language for modern image processing algorithms. The advantages of the interactive system are illustrated by an example of diagnosis by nuclear methods. (orig.) [de

  8. Molten Core - Concrete interactions in nuclear accidents. Theory and design of an experimental facility

    International Nuclear Information System (INIS)

    Sevon, T.

    2005-11-01

    In a hypothetical severe accident in a nuclear power plant, the molten core of the reactor may flow onto the concrete floor of containment building. This would cause a molten core . concrete interaction (MCCI), in which the heat transfer from the hot melt to the concrete would cause melting of the concrete. In assessing the safety of nuclear reactors, it is important to know the consequences of such an interaction. As background to the subject, this publication includes a description of the core melt stabilization concept of the European Pressurized water Reactor (EPR), which is being built in Olkiluoto in Finland. The publication includes a description of the basic theory of the interaction and the process of spalling or cracking of concrete when it is heated rapidly. A literature survey and some calculations of the physical properties of concrete and corium. concrete mixtures at high temperatures have been conducted. In addition, an equation is derived for conservative calculation of the maximum possible concrete ablation depth. The publication also includes a literature survey of experimental research on the subject of the MCCI and discussion of the results and deficiencies of the experiments. The main result of this work is the general design of an experimental facility to examine the interaction of molten metals and concrete. The main objective of the experiments is to assess the probability of spalling, or cracking, of concrete under pouring of molten material. A program of five experiments has been designed, and pre-test calculations of the experiments have been conducted with MELCOR 1.8.5 accident analysis program and conservative analytic calculations. (orig.)

  9. Theoretical studies of multistep processes. Isospin effects in nuclear scattering, and meson and baryon interactions in nuclear physics. Progress report

    International Nuclear Information System (INIS)

    Madsen, V.A.; Landau, R.H.

    1985-12-01

    Research on microscopic optical potentials, multistep processes, neutron-proton differences in nuclear vibrations, and exact calculations of Coulomb plus nuclear bound states of exotic systems is reported. 21 refs

  10. The importance of input interactions in the uncertainty and sensitivity analysis of nuclear fuel behavior

    Energy Technology Data Exchange (ETDEWEB)

    Ikonen, T., E-mail: timo.ikonen@vtt.fi; Tulkki, V.

    2014-08-15

    Highlights: • Uncertainty and sensitivity analysis of modeled nuclear fuel behavior is performed. • Burnup dependency of the uncertainties and sensitivities is characterized. • Input interactions significantly increase output uncertainties for irradiated fuel. • Identification of uncertainty sources is greatly improved with higher order methods. • Results stress the importance of using methods that take interactions into account. - Abstract: The propagation of uncertainties in a PWR fuel rod under steady-state irradiation is analyzed by computational means. A hypothetical steady-state scenario of the Three Mile Island 1 reactor fuel rod is modeled with the fuel performance FRAPCON, using realistic input uncertainties for the fabrication and model parameters, boundary conditions and material properties. The uncertainty and sensitivity analysis is performed by extensive Monte Carlo sampling of the inputs’ probability distribution and by applying correlation coefficient and Sobol’ variance decomposition analyses. The latter includes evaluation of the second order and total effect sensitivity indices, allowing the study of interactions between input variables. The results show that the interactions play a large role in the propagation of uncertainties, and first order methods such as the correlation coefficient analyses are in general insufficient for sensitivity analysis of the fuel rod. Significant improvement over the first order methods can be achieved by using higher order methods. The results also show that both the magnitude of the uncertainties and their propagation depends not only on the output in question, but also on burnup. The latter is due to onset of new phenomena (such as the fission gas release) and the gradual closure of the pellet-cladding gap with increasing burnup. Increasing burnup also affects the importance of input interactions. Interaction effects are typically highest in the moderate burnup (of the order of 10–40 MWd

  11. A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response

    DEFF Research Database (Denmark)

    Blasius, Melanie; Wagner, Sebastian A; Choudhary, Chuna Ram

    2014-01-01

    RNA metabolism is altered following DNA damage, but the underlying mechanisms are not well understood. Through a 14-3-3 interaction screen for DNA damage-induced protein interactions in human cells, we identified protein complexes connected to RNA biology. These include the nuclear exosome...

  12. Characteristics of Soil Structure Interaction for Reactor Building of Kashiwazaki-Kariwa Nuclear Power Plant

    International Nuclear Information System (INIS)

    Gil, Moon Joo; Jung, Rae Young; Hyun, Chang Hun; Kim, Moon Soo; Lim, Nam Hyoung

    2010-01-01

    On 16 July 2007, the Nigataken-chuetsu-oki earthquake registering a moment magnitude of 6.8 occurred at a depth of about 15 km. As a result of this earthquake, noticeable shaking exceeding the design ground motion was measured at the Tokyo Electric Power Company (TEPCO) Kashiwazaki-Kariwa Nuclear Power Station (KKN), the biggest nuclear power plant in the world, located at about 16 km away from the epicenter. This earthquake triggered a fire at an electrical transformer and insignificant damage on some parts of facilities. This event gave an impulse to study on the damage and safety margin of nuclear power plant due to the strong earthquake exceeding design basis. As a part of those efforts, KARISMA (KAshiwazaki-Kariwa Research Initiative for Seismic Margin Assessment) benchmark study was launched by the IAEA in terms of an international collaborative research. The main objectives of this research are to estimate the structural behavior and to evaluate the seismic margin of reactor building considering the effects of Soil-Structure Interaction (SSI). This paper presents verification of structural model developed here and validation of soil foundation characteristics through soil-column analysis. It has also been demonstrated that the spring constants and damping coefficient obtained from impedance analysis represent well the soil foundation characteristics

  13. Effective interactions and mean field theory: from nuclear matter to nuclei

    International Nuclear Information System (INIS)

    Cochet, B.

    2005-07-01

    The Skyrme force is a zero-range force that allows the construction of the mean field inside the nucleus in a simple way. Skyrme forces are reasonably predictive but some features of the infinite nuclear matter or the mass of heavy nuclei are not well computed. The aim of this work is to propose an expanded parametrization of the Skyrme force in order to improve its predictive power. The first part is dedicated to the construction of the expansion of the parametrization. We recall how the effective forces are linked to the nucleon-nucleon interaction then we show the limits of the standard Skyrme forces and we propose a relatively natural improvements based on the integration of spin and isospin instabilities. The second part deals with the validation of the model, first by describing infinite nuclear matter then by studying β-balanced nuclear matter which has enabled us to reproduce some features of neutron stars like mass and radius. The computation of properties of nuclei like binding energy, mass, radii depends strongly on the adjustment procedure. (A.C.)

  14. Nuclear Energy and Renewables interaction: System Effects in Low-carbon Electricity Systems

    International Nuclear Information System (INIS)

    Keppler, Jan Horst; Cometto, Marco

    2013-01-01

    This report presents a synthesis of the OECD/NEA study 'Nuclear Energy and Renewables: System Effects in Low-carbon Electricity Systems'. It addresses the increasingly important interactions of variable renewables and dispatchable energy technologies, such as nuclear power, in terms of their effects on electricity systems. These effects add costs to the production of electricity, which are not usually transparent. The report recommends that decision-makers should take into account such system costs and internalise them according to a 'generator pays' principle, which is currently not the case. Analysing data from six OECD/NEA countries, the study finds that including the system costs of variable renewables at the level of the electricity grid increases the total costs of electricity supply by up to one-third, depending on technology, country and penetration levels. In addition, it concludes that, unless the current market subsidies for renewables are altered, dispatchable technologies will increasingly not be replaced as they reach their end of life and consequently security of supply will suffer. This implies that significant changes in management and cost allocation will be needed to generate the flexibility required for an economically viable coexistence of nuclear energy and renewables in increasingly de-carbonised electricity systems

  15. General aspects of the nucleon-nucleon interaction and nuclear matter properties

    Energy Technology Data Exchange (ETDEWEB)

    Plohl, Oliver

    2008-07-25

    The subject of the present thesis is at first the investigation of model independent properties of the nucleon-nucleon (NN) interaction in the vacuum concerning the relativistic structure and the implications for nuclear matter properties. Relativistic and non-relativistic meson-exchange potentials, phenomenological potentials s well as potentials based on effective field theory (EFT) are therefore mapped on a relativistic operator basis given by the Clifford Algebra. This allows to compare the various approaches at the level of covariant amplitudes where a remarkable agreement is found. Furthermore, the relativistic self-energy is determined in the Hartree-Fock (HF) approximation. The appearance of a scalar and vector field of several hundred MeV magnitude is a general feature of relativistic descriptions of nuclear matter. Within QCD sum rules these fields arise due to the density dependence of chiral condensates. We find that independent of the applied NN interaction large scalar and vector fields are generated when the symmetries of the Lorentz group are restored. In the framework of chiral EFT (chEFT) it is shown, that these fields are generated by short-range next-to-leading order (NLO) contact terms, which are connected to the spin-orbit interaction. To estimate the effect arising from NN correlations the equation of state of nuclear and neutron matter is calculated in the Brueckner-HF (BHF) approximation applying chEFT. Although, as expected, a clear over-binding is found (at NLO a saturating behavior is observed), the symmetry energy shows realistic properties when compared to phenomenological potentials (within the same approximation) and other approaches. The investigation of the pion mass dependence within chEFT at NLO shows that the magnitude of the scalar and vector fields persists in the chiral limit - nuclear matter is still bound. In contrast to the case of a pion mass larger than the physical one the binding energy and saturation density are

  16. General aspects of the nucleon-nucleon interaction and nuclear matter properties

    International Nuclear Information System (INIS)

    Plohl, Oliver

    2008-01-01

    The subject of the present thesis is at first the investigation of model independent properties of the nucleon-nucleon (NN) interaction in the vacuum concerning the relativistic structure and the implications for nuclear matter properties. Relativistic and non-relativistic meson-exchange potentials, phenomenological potentials s well as potentials based on effective field theory (EFT) are therefore mapped on a relativistic operator basis given by the Clifford Algebra. This allows to compare the various approaches at the level of covariant amplitudes where a remarkable agreement is found. Furthermore, the relativistic self-energy is determined in the Hartree-Fock (HF) approximation. The appearance of a scalar and vector field of several hundred MeV magnitude is a general feature of relativistic descriptions of nuclear matter. Within QCD sum rules these fields arise due to the density dependence of chiral condensates. We find that independent of the applied NN interaction large scalar and vector fields are generated when the symmetries of the Lorentz group are restored. In the framework of chiral EFT (chEFT) it is shown, that these fields are generated by short-range next-to-leading order (NLO) contact terms, which are connected to the spin-orbit interaction. To estimate the effect arising from NN correlations the equation of state of nuclear and neutron matter is calculated in the Brueckner-HF (BHF) approximation applying chEFT. Although, as expected, a clear over-binding is found (at NLO a saturating behavior is observed), the symmetry energy shows realistic properties when compared to phenomenological potentials (within the same approximation) and other approaches. The investigation of the pion mass dependence within chEFT at NLO shows that the magnitude of the scalar and vector fields persists in the chiral limit - nuclear matter is still bound. In contrast to the case of a pion mass larger than the physical one the binding energy and saturation density are

  17. Nuclear interactions of high energy heavy ions and applications in astrophysics

    International Nuclear Information System (INIS)

    Wefel, J.P.

    1992-01-01

    This program was established for the purpose of studying projectile fragmentation; (1) as a function of energy, focusing first on the intermediate energy region, < 1 GeV/nucleon, where there have been few previous measurements and no systematic studies, and (2) as a function of projectile mass, starting with light beams and proceeding to species as heavy as nickel (and possibly beyond). The intermediate energy region is important as the transition between the lower energy data, where the interaction appears to be dominated by collective effects and the decay of excited nuclei, and the highest energy results, where nucleon-nucleon interactions are fundamental, ''limiting fragmentation'' applies, and the nucleus may well break-up before any de-excitation. The mass dependence of projectile fragmentation is largely unknown since most detailed work has involved light ion beams. Nuclear structure effects, for example, may well be quite prominent for heavier beams. Furthermore, the nuclear excitation functions for the production of different fragment isotopes have immediate application to the astrophysical interpretation of existing isotopic datasets obtained from balloon and satellite measurements of galactic cosmic rays

  18. A virtual control room with an embedded, interactive nuclear reactor simulator

    International Nuclear Information System (INIS)

    Markidis, S.; Rizwan, U.

    2006-01-01

    The use of virtual nuclear control room can be an effective and powerful tool for training personnel working in the nuclear power plants. Operators could experience and simulate the functioning of the plant, even in critical situations, without being in a real power plant or running any risk. 3D models can be exported to Virtual Reality formats and then displayed in the Virtual Reality environment providing an immersive 3D experience. However, two major limitations of this approach are that 3D models exhibit static textures, and they are not fully interactive and therefore cannot be used effectively in training personnel. In this paper we first describe a possible solution for embedding the output of a computer application in a 3D virtual scene, coupling real-world applications and VR systems. The VR system reported here grabs the output of an application running on an X server; creates a texture with the output and then displays it on a screen or a wall in the virtual reality environment. We then propose a simple model for providing interaction between the user in the VR system and the running simulator. This approach is based on the use of internet-based application that can be commanded by a laptop or tablet-pc added to the virtual environment. (authors)

  19. Di-nucleon structures in homogeneous nuclear matter based on two- and three-nucleon interactions

    Energy Technology Data Exchange (ETDEWEB)

    Arellano, Hugo F. [University of Chile, Department of Physics - FCFM, Santiago (Chile); CEA, DAM, DIF, Arpajon (France); Isaule, Felipe [University of Chile, Department of Physics - FCFM, Santiago (Chile); Rios, Arnau [University of Surrey, Department of Physics, Faculty of Engineering and Physical Sciences, Guildford (United Kingdom)

    2016-09-15

    We investigate homogeneous nuclear matter within the Brueckner-Hartree-Fock (BHF) approach in the limits of isospin-symmetric nuclear matter (SNM) as well as pure neutron matter at zero temperature. The study is based on realistic representations of the internucleon interaction as given by Argonne v{sub 18}, Paris, Nijmegen I and II potentials, in addition to chiral N{sup 3}LO interactions, including three-nucleon forces up to N{sup 2}LO. Particular attention is paid to the presence of di-nucleon bound states structures in {sup 1}S{sub 0} and {sup 3}SD{sub 1} channels, whose explicit account becomes crucial for the stability of self-consistent solutions at low densities. A characterization of these solutions and associated bound states is discussed. We confirm that coexisting BHF single-particle solutions in SNM, at Fermi momenta in the range 0.13-0.3 fm{sup -1}, is a robust feature under the choice of realistic internucleon potentials. (orig.)

  20. Web-based, Interactive, Nuclear Reactor Transient Analyzer using LabVIEW and RELAP5 (ATHENA)

    International Nuclear Information System (INIS)

    Kim, K. D.; Chung, B. D.; Rizwan-uddin

    2006-01-01

    In nuclear engineering, large system analysis codes such as RELAP5, TRAC-M, etc. play an important role in evaluating a reactor system behavior during a wide range of transient conditions. One limitation that restricts their use on a wider scale is that these codes often have a complicated I/O structure. This has motivated the development of GUI tools for best estimate codes, such as SNAP and ViSA, etc. In addition to a user interface, a greater degree of freedom in simulation and analyses of nuclear transient phenomena can be achieved if computer codes and their outputs are accessible from anywhere through the web. Such a web-based interactive interface can be very useful for geographically distributed groups when there is a need to share real-time data. Using mostly off-the-shelf technology, such a capability - a web-based transient analyzer based on a best-estimate code - has been developed. Specifically, the widely used best-estimate code RELAP5 is linked with a graphical interface. Moreover, a capability to web-cast is also available. This has been achieved by using the LabVIEW virtual instruments (VIs). In addition to the graphical display of the results, interactive control functions have also been added that allow operator's actions as well as, if permitted, by a distant user through the web

  1. Accelerating nuclear configuration interaction calculations through a preconditioned block iterative eigensolver

    Science.gov (United States)

    Shao, Meiyue; Aktulga, H. Metin; Yang, Chao; Ng, Esmond G.; Maris, Pieter; Vary, James P.

    2018-01-01

    We describe a number of recently developed techniques for improving the performance of large-scale nuclear configuration interaction calculations on high performance parallel computers. We show the benefit of using a preconditioned block iterative method to replace the Lanczos algorithm that has traditionally been used to perform this type of computation. The rapid convergence of the block iterative method is achieved by a proper choice of starting guesses of the eigenvectors and the construction of an effective preconditioner. These acceleration techniques take advantage of special structure of the nuclear configuration interaction problem which we discuss in detail. The use of a block method also allows us to improve the concurrency of the computation, and take advantage of the memory hierarchy of modern microprocessors to increase the arithmetic intensity of the computation relative to data movement. We also discuss the implementation details that are critical to achieving high performance on massively parallel multi-core supercomputers, and demonstrate that the new block iterative solver is two to three times faster than the Lanczos based algorithm for problems of moderate sizes on a Cray XC30 system.

  2. The screening length of interatomic potential in atomic collisions

    International Nuclear Information System (INIS)

    Yamamura, Y.; Takeuchi, W.; Kawamura, T.

    1998-03-01

    In computer studies on the interaction of charged particle with solids, many authors treat the nuclear collision by the Thomas-Fermi screened Coulomb potential. For better agreement with experiment, the screening length is modified sometimes. We investigate the theoretical background for the correction factor of the screening length in the interatomic potential which can be deduced from two steps. The first step is to select the correction factor of an isolated atom so as to match the average radius of the Thomas-Fermi electron distribution with that of the Hartree-Fock electron distribution, where we use the Clementi and Roetti's table. The second step is to determine the correction factor of the screening length of the interatomic potential by using a combination rule. The correction factors obtained for the screening length are in good agreement with those determined by the computer analysis of the Impact Collision Ion Scattering Spectroscopy (ICISS) data. (author)

  3. Characterization of a 65 kDa NIF in the nuclear matrix of the monocot Allium cepa that interacts with nuclear spectrin-like proteins.

    Science.gov (United States)

    Pérez-Munive, Clara; Blumenthal, Sonal S D; de la Espina, Susana Moreno Díaz

    2012-01-01

    Plant cells have a well organized nucleus and nuclear matrix, but lack orthologues of the main structural components of the metazoan nuclear matrix. Although data is limited, most plant nuclear structural proteins are coiled-coil proteins, such as the NIFs (nuclear intermediate filaments) in Pisum sativum that cross-react with anti-intermediate filament and anti-lamin antibodies, form filaments 6-12 nm in diameter in vitro, and may play the role of lamins. We have investigated the conservation and features of NIFs in a monocot species, Allium cepa, and compared them with onion lamin-like proteins. Polyclonal antisera against the pea 65 kDa NIF were used in 1D and 2D Western blots, ICM (imunofluorescence confocal microscopy) and IEM (immunoelectron microscopy). Their presence in the nuclear matrix was analysed by differential extraction of nuclei, and their association with structural spectrin-like proteins by co-immunoprecipitation and co-localization in ICM. NIF is a conserved structural component of the nucleus and its matrix in monocots with Mr and pI values similar to those of pea 65 kDa NIF, which localized to the nuclear envelope, perichromatin domains and foci, and to the nuclear matrix, interacting directly with structural nuclear spectrin-like proteins. Its similarities with some of the proteins described as onion lamin-like proteins suggest that they are highly related or perhaps the same proteins.

  4. Interactions of RuO4(g) with different surfaces in nuclear reactor containments

    International Nuclear Information System (INIS)

    Holm, J.; Glaenneskog, H.; Ekberg, C.

    2008-07-01

    During a severe nuclear reactor accident with air ingress, ruthenium in the form of RuO4 can be released from the nuclear fuel. Hence, it is important to investigate how the reactor containment is able to reduce the source term of ruthenium. This work has investigated the distribution of RuO4 between an aqueous and gaseous phase in the temperature interval of 20-50 deg. C by on-line measurements with an experimental set-up made of glass. The experiments showed that RuO4 is almost immediately distributed in the aqueous phase after its introduction in the set-up in the entire temperature interval. However, the deposition of ruthenium on the glass surfaces in the system was significant. The speciation of the ruthenium on the glass surfaces was studied by SEM-EDX and ESCA and was determined to be the expected RuO2. Experiments of interactions between gaseous ruthenium tetroxide and the metals aluminium, copper and zinc have been investigated. The metals were treated by RuO4 (g) at room temperature and analyzed with ESCA, SEM and XRD. The analyses show that the black ruthenium deposits on the metal surfaces were RuO2, i.e. the RuO4 (g) has been transformed on the metal surfaces to RuO2(s). The analyses showed also that there was a significant deposition of ruthenium tetroxide especially on the copper and zinc samples. Aluminium has a lower ability to deposit gaseous ruthenium tetroxide than the other metals. The conclusion that can be made from the results is that surfaces in nuclear reactor containments will likely reduce the source term in the case of a severe accident in a nuclear power plant. (au)

  5. SIRT1 interacts with and protects glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from nuclear translocation: Implications for cell survival after irradiation

    International Nuclear Information System (INIS)

    Joo, Hyun-Yoo; Woo, Seon Rang; Shen, Yan-Nan; Yun, Mi Yong; Shin, Hyun-Jin; Park, Eun-Ran; Kim, Su-Hyeon; Park, Jeong-Eun; Ju, Yeun-Jin; Hong, Sung Hee; Hwang, Sang-Gu; Cho, Myung-Haing; Kim, Joon; Lee, Kee-Ho

    2012-01-01

    Highlights: ► SIRT1 serves to retain GAPDH in the cytosol, preventing GAPDH nuclear translocation. ► When SIRT1 is depleted, GAPDH translocation occurs even in the absence of stress. ► Upon irradiation, SIRT1 interacts with GAPDH. ► SIRT1 prevents irradiation-induced nuclear translocation of GAPDH. ► SIRT1 presence rather than activity is essential for inhibiting GAPDH translocation. -- Abstract: Upon apoptotic stimulation, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a cytosolic enzyme normally active in glycolysis, translocates into the nucleus and activates an apoptotic cascade therein. In the present work, we show that SIRT1 prevents nuclear translocation of GAPDH via interaction with GAPDH. SIRT1 depletion triggered nuclear translocation of cytosolic GAPDH even in the absence of apoptotic stress. Such translocation was not, however, observed when SIRT1 enzymatic activity was inhibited, indicating that SIRT1 protein per se, rather than the deacetylase activity of the protein, is required to inhibit GAPDH translocation. Upon irradiation, SIRT1 prevented irradiation-induced nuclear translocation of GAPDH, accompanied by interaction of SIRT1 and GAPDH. Thus, SIRT1 functions to retain GAPDH in the cytosol, protecting the enzyme from nuclear translocation via interaction with these two proteins. This serves as a mechanism whereby SIRT1 regulates cell survival upon induction of apoptotic stress by means that include irradiation.

  6. p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1.

    Directory of Open Access Journals (Sweden)

    Xiao-Su Zhao

    Full Text Available Cyclin-dependent kinase 5 (Cdk5 is a proline-directed serine/threonine kinase, which plays critical roles in a wide spectrum of neuronal functions including neuronal survival, neurite outgrowth, and synapse development and plasticity. Cdk5 activity is controlled by its specific activators: p35 or p39. While knockout studies reveal that Cdk5/p35 is critical for neuronal migration during early brain development, functions of Cdk5/p35 have been unraveled through the identification of the interacting proteins of p35, most of which are Cdk5/p35 substrates. However, it remains unclear whether p35 can regulate neuronal functions independent of Cdk5 activity. Here, we report that a nuclear protein, nuclear hormone receptor coregulator (NRC-interacting factor 1 (NIF-1, is a new interacting partner of p35. Interestingly, p35 regulates the functions of NIF-1 independent of Cdk5 activity. NIF-1 was initially discovered as a transcriptional regulator that enhances the transcriptional activity of nuclear hormone receptors. Our results show that p35 interacts with NIF-1 and regulates its nucleocytoplasmic trafficking via the nuclear export pathway. Furthermore, we identified a nuclear export signal on p35; mutation of this site or blockade of the CRM1/exportin-dependent nuclear export pathway resulted in the nuclear accumulation of p35. Intriguingly, blocking the nuclear export of p35 attenuated the nuclear accumulation of NIF-1. These findings reveal a new p35-dependent mechanism in transcriptional regulation that involves the nucleocytoplasmic shuttling of transcription regulators.

  7. p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1).

    Science.gov (United States)

    Zhao, Xiao-Su; Fu, Wing-Yu; Chien, Winnie W Y; Li, Zhen; Fu, Amy K Y; Ip, Nancy Y

    2014-01-01

    Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, which plays critical roles in a wide spectrum of neuronal functions including neuronal survival, neurite outgrowth, and synapse development and plasticity. Cdk5 activity is controlled by its specific activators: p35 or p39. While knockout studies reveal that Cdk5/p35 is critical for neuronal migration during early brain development, functions of Cdk5/p35 have been unraveled through the identification of the interacting proteins of p35, most of which are Cdk5/p35 substrates. However, it remains unclear whether p35 can regulate neuronal functions independent of Cdk5 activity. Here, we report that a nuclear protein, nuclear hormone receptor coregulator (NRC)-interacting factor 1 (NIF-1), is a new interacting partner of p35. Interestingly, p35 regulates the functions of NIF-1 independent of Cdk5 activity. NIF-1 was initially discovered as a transcriptional regulator that enhances the transcriptional activity of nuclear hormone receptors. Our results show that p35 interacts with NIF-1 and regulates its nucleocytoplasmic trafficking via the nuclear export pathway. Furthermore, we identified a nuclear export signal on p35; mutation of this site or blockade of the CRM1/exportin-dependent nuclear export pathway resulted in the nuclear accumulation of p35. Intriguingly, blocking the nuclear export of p35 attenuated the nuclear accumulation of NIF-1. These findings reveal a new p35-dependent mechanism in transcriptional regulation that involves the nucleocytoplasmic shuttling of transcription regulators.

  8. Models test on dynamic structure-structure interaction of nuclear power plant buildings

    International Nuclear Information System (INIS)

    Kitada, Y.; Hirotani, T.

    1999-01-01

    A reactor building of an NPP (nuclear power plant) is generally constructed closely adjacent to a turbine building and other buildings such as the auxiliary building, and in increasing numbers of NPPs, multiple plants are being planned and constructed closely on a single site. In these situations, adjacent buildings are considered to influence each other through the soil during earthquakes and to exhibit dynamic behaviour different from that of separate buildings, because those buildings in NPP are generally heavy and massive. The dynamic interaction between buildings during earthquake through the soil is termed here as 'dynamic cross interaction (DCI)'. In order to comprehend DCI appropriately, forced vibration tests and earthquake observation are needed using closely constructed building models. Standing on this background, Nuclear Power Engineering Corporation (NUPEC) had planned the project to investigate the DCI effect in 1993 after the preceding SSI (soil-structure interaction) investigation project, 'model tests on embedment effect of reactor building'. The project consists of field and laboratory tests. The field test is being carried out using three different building construction conditions, e.g. a single reactor building to be used for the comparison purposes as for a reference, two same reactor buildings used to evaluate pure DCI effects, and two different buildings, reactor and turbine building models to evaluate DCI effects under the actual plant conditions. Forced vibration tests and earthquake observations are planned in the field test. The laboratory test is planned to evaluate basic characteristics of the DCI effects using simple soil model made of silicon rubber and structure models made of aluminum. In this test, forced vibration tests and shaking table tests are planned. The project was started in April 1994 and will be completed in March 2002. This paper describes an outline and the summary of the current status of this project. (orig.)

  9. Experimental studies of thermal and chemical interactions between molten aluminum and nuclear dispersion fuels with water

    International Nuclear Information System (INIS)

    Farahani, A.A.

    1997-01-01

    Because of the possibility of rapid physical and chemical molten fuel-water interactions during a core melt accident in noncommercial or experimental reactors, it is important to understand the interactions that might occur if these materials were to contact water. An existing vertical 1-D shock tube facility was improved and a gas sampling device to measure the gaseous hydrogen in the upper chamber of the shock tube was designed and built to study the impact of a water column driven downward by a pressurized gas onto both molten aluminum (6061 alloy) and oxide and silicide depleted nuclear dispersion fuels in aluminum matrices. The experiments were carried out with melt temperatures initially at 750 to 1,000 C and water at room temperature and driving pressures of 0.5 and 1 MPa. Very high transient pressures, in many cases even larger than the thermodynamic critical pressure of the water (∼ 20 MPa), were generated due to the interactions between the water and the crucible and its contents. The molten aluminum always reacted chemically with the water but the reaction did not increase consistently with increasing melt temperature. An aluminum ignition occurred when water at room temperature impacted 28.48 grams of molten aluminum at 980.3 C causing transient pressures greater than 69 MPa. No signs of aluminum ignition were observed in any of the experiments with the depleted nuclear dispersion fuels, U 3 O 8 -Al and U 3 Si 2 -Al. The greater was the molten aluminum-water chemical reaction, the finer was the debris recovered for a given set of initial conditions. Larger coolant velocities (larger driving pressures) resulted in more melt fragmentation but did not result in more molten aluminum-water chemical reaction. Decreasing the water temperature also resulted in more melt fragmentation and did not suppress the molten aluminum-water chemical reaction

  10. Isoscalar spin-spin interaction within the quasiparticle-phonon nuclear model

    International Nuclear Information System (INIS)

    Dao Tien Khoa; Ponomarev, V.Yu.; Vdovin, A.I.

    1986-01-01

    The isoscalar spin-spin interaction constant in the quasiparticle-phonon nuclear model (QPM) has been determined from the available experimental data on the isoscalar 1 + state (E x =5.846 MeV) in 208 Pb. The isoscalar spin-spin interaction turns out to be weaker than the isovector one by an order of magnitude. The cross sections of (e, e') and (p, p') reactions with the excitation of this 1 + -state have been calculated. The QPM gives a good description of the behaviour of (e, e')-cross section at q eff -1 and reproduces absolute value of this cross section with the effective g s -factors weaker than the g s -factors for free nucleon by 20%. The description of the (p, p')-angular distribution of 201 MeV photon inelastic scattering is poorer. The absolute value of the calculated (p, p') cross section overestimates the experimental data by a factor of about 1.4. This is consistent with the quenching factor for (e, e') cross section. The interaction with two-phonon configurations influences very weakly the isoscalar 1 + -level

  11. The insulator protein SU(HW fine-tunes nuclear lamina interactions of the Drosophila genome.

    Directory of Open Access Journals (Sweden)

    Joke G van Bemmel

    Full Text Available Specific interactions of the genome with the nuclear lamina (NL are thought to assist chromosome folding inside the nucleus and to contribute to the regulation of gene expression. High-resolution mapping has recently identified hundreds of large, sharply defined lamina-associated domains (LADs in the human genome, and suggested that the insulator protein CTCF may help to demarcate these domains. Here, we report the detailed structure of LADs in Drosophila cells, and investigate the putative roles of five insulator proteins in LAD organization. We found that the Drosophila genome is also organized in discrete LADs, which are about five times smaller than human LADs but contain on average a similar number of genes. Systematic comparison to new and published insulator binding maps shows that only SU(HW binds preferentially at LAD borders and at specific positions inside LADs, while GAF, CTCF, BEAF-32 and DWG are mostly absent from these regions. By knockdown and overexpression studies we demonstrate that SU(HW weakens genome - NL interactions through a local antagonistic effect, but we did not obtain evidence that it is essential for border formation. Our results provide insights into the evolution of LAD organization and identify SU(HW as a fine-tuner of genome - NL interactions.

  12. Effective interaction for relativistic mean-field theories of nuclear structure

    International Nuclear Information System (INIS)

    Ai, H.B.; Celenza, L.S.; Harindranath, A.; Shakin, C.M.

    1987-01-01

    We construct an effective interaction, which when treated in a relativistic Hartree-Fock approximation, reproduces rather accurately the nucleon self-energy in nuclear matter and the Migdal parameters obtained via relativistic Brueckner-Hartree-Fock calculations. This effective interaction is constructed by adding Born terms, describing the exchange of pseudoparticles, to the Born terms of the Dirac-Hartree-Fock analysis. The pseudoparticles have relatively large masses and either real or imaginary coupling constants. (For example, exchange of a pseudo-sigma with an imaginary coupling constant has the effect of reducing the scalar attraction arising from sigma exchange while exchange of a pseudo-omega with an imaginary coupling constant has the effect of reducing the repulsion arising from omega exchange. The terms beyond the Born term in the case of pion exchange are well simulated by pseudo-sigma exchange with a real coupling constant.) The effective interaction constructed here may be used for calculations of the properties of finite nuclei in a relativistic Hartree-Fock approximation

  13. Investigation of the influence of nuclear matter on hard neutrino nucleus interaction using the HARDPING Monte Carlo Event Generator

    International Nuclear Information System (INIS)

    Berdnikov, Ya.A.; Berdnikov, A.Ya.; Kim, V.T.; Ivanov, A.E.; Suetin, D.P.; Tiangov, K.D.

    2016-01-01

    Hadron production in neutrino-nucleus interactions is implemented in Monte Carlo event generator HARDPING (HARD Probe INteraction Generator). Such effects as formation length, energy loss and multiple rescattering for produced hadrons and their constituents are taken into account in HARDPING. Available data from WA/59 and SCAT collaborations on hadron production in neutrino-nucleus collisions is described by HARDPING with a reasonable agreement

  14. Debye sheath mechanism at laser plasma interaction and generalization to nuclear forces and quark-gluon plasma

    Science.gov (United States)

    Osman, Frederick; Ghahramani, Nader; Hora, Heinrich

    2005-10-01

    The studies of laser ablation have lead to a new theory of nuclei, endothermic nuclei generation, and quark-gluon plasmas. The surface of ablated plasma expanding into vacuum after high power laser irradiation of targets contains an electric double layer having the thickness of the Debye length. This led to the discovery of surface tension in plasmas, and led to the internal dynamic electric fields in all inhomogeneous plasmas. The surface tension causes stabilization by short length surface wave smoothing the expanding plasma plume and to stabilization against the Rayleigh Taylor instability. Generalizing this to the degenerate electrons in a metal with the Fermi energy instead of the temperature resulted in the first quantum theory of surface tension of metals in agreement with measurements. Taking the Fermi energy in the Debye length for nucleons results in a theory of nuclei with stable confinement of protons and neutrons just at the well-known nuclear density, and the Debye lengths equal to the Hofstadter decay of the nuclear surface. Increasing the nuclear density by a factor of 10 leads to a change of the Fermi energy into its relativistic branch where no surface energy is possible and the particle mass is not defined, permitting the quark gluon plasma. Expansion of this higher density at the big bang or in super-nova results in nucleation and element generation. The Boltzmann equilibrium permits the synthesis of nuclei even in the endothermic range, however with the limit to about uranium. A relation for the magic numbers leads to a quark structure of nuclear shells that can be understood as a duality property of nuclei with respect to nucleons and quarks

  15. Floor Response Spectra of Nuclear Containment Building with Soil-Structure Interaction

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Choon Gyo; Ryu, Jeong Soo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2008-10-15

    This paper presents a seismic analysis technique for a 3D soil-structure interaction(SSI) system in frequency domain, based on the finite element formulation incorporating frequency-dependent dynamic infinite elements for the far field soil region. Earthquake input motions are regarded as traveling SV-wave which is vertically incident from a far-field soil region. In which, the equivalent earthquake forces in the frequency domain are calculated using the exterior rigid boundary method and the free field response analysis. For the application, floor response spectra analyses for nuclear containment building on a soil medium is carried out, the obtained results are compared with the free field response by other solution.

  16. Midi-maxi computer interaction in the interpretation of nuclear medicine procedures

    International Nuclear Information System (INIS)

    Schlapper, G.A.

    1977-01-01

    A study of renal function with an Anger Gamma Camera coupled with a Digital Equipment Corporation Gamma-11 System and an IBM System 370 demonstrates the potential of quantitative determinations of physiological function through the application of midi-maxi computer interaction in the interpretation of nuclear medicine procedures. It is shown that radiotracers can provide an opportunity to assess physiological processes of renal function by noninvasively following the path of a tracer as a function of time. Time-activity relationships obtained over seven anatomically defined regions are related to parameters of a seven compartment model employed to describe the renal clearance process. The values obtained for clinically significant parameters agree with known renal pathophysiology. Differentiation of failure of acute, chronic, and obstructive forms is indicated

  17. Team interaction skills evaluation criteria for nuclear power plant control room operators

    International Nuclear Information System (INIS)

    Montgomery, J.C.; Toquam, J.; Gaddy, C.

    1991-09-01

    Previous research has shown the value of good team interaction skills to group performance, yet little progress has been made on in terms of how such skills can be measured. In this study rating scales developed previously (Montgomery, et al., 1990) were extensively revised and cast into a Behaviorally Anchored Rating Scale (BARS) and a Behavioral Frequency format. Rating data were collected using 13 training instructors at the Diablo Canyon Nuclear Plant, who rated three videotapes of simulator scenario performance during a day-long training session and later evaluated control room crews during requalification training. High levels of interrater agreement on both rating scales were found. However, the factor structure of the ratings was generally inconsistent with that hypothesized. Analysis of training ratings using Cronbach's components of accuracy (Cronbach, 1955) indicated that BARS ratings generally exhibited less error than did the Behavioral Frequency ratings. The results are discussed in terms of both field and research implications

  18. Soil structure interaction model and variability of parameters in seismic analysis of nuclear island connected building

    International Nuclear Information System (INIS)

    Subramanian, K.V.; Palekar, S.M.; Bavare, M.S.; Mapari, H.A.; Patel, S.C.; Pillai, C.S.

    2005-01-01

    This paper provides salient features of the Soil Structure Interaction analysis of Nuclear Island Connected Building (NICB). The dynamic analysis of NICB is performed on a full 3D model accounting for the probable variation in the stiffness of the founding medium. A range analyses was performed to establish the effect of variability of subgrade parameters on the results of seismic analyses of NICB. This paper presents details of various analyses with respect to the subgrade model, uncertainties in subgrade properties, results of seismic analyses and a study of effect of the variability of parameters on the results of these analyses. The results of this study indicate that the variability of soil parameters beyond a certain value of shear wave velocity does not influence the response and in fact the response marginally diminishes. (authors)

  19. Radiation factors and smoking interaction at lung cancer incidence for workers at a nuclear enterprise

    International Nuclear Information System (INIS)

    Tokarskaya, Z.B.; Khokhryakov, V.T.; Okladnikova, N.D.; Belyaeva, Z.D.; Zhuntova, G.V.; Fleck, C.M.; Schollnberger, H.; Drozhko, E.G.

    1998-01-01

    A study is reported which is a continuation of a previous investigation of lung cancer incidence in workers at a nuclear enterprise and its relation to three basic etiological factors: the body burden due to 239 Pu, chronic external gamma irradiation, and smoking. Whereas previously each of the factors was assessed separately, in the present study the attempt was made to assess the interaction of the factors. A statistical analysis of the data revealed that for the following pairs of factors a superposition effect could be seen: external gamma irradiation and 239 Pu body burden; external gamma irradiation and a medium level of smoking; and 239 Pu body burden and a medium level of smoking. (A.K.)

  20. 14N nuclear quadrupole interaction in Cu(II) doped L-alanine

    International Nuclear Information System (INIS)

    Murgich, J.; Calvo, R.; Oseroff, S.B.; Instituto Venezolano de Investigaciones Cientificas, Caracas. Dept. de Quimica)

    1980-01-01

    The 14 N nuclear quadrupole interaction tensor Psub(N) measured by ENDOR in Cu(II) doped L-alanine is analyzed in terms of the Townes and Daily theory assuming a tetra-hedrally bonded N atom. The results of this analysis are compared with those for the 14 N in pure L-alanine and it is found that the principal directions of the Psub(N) tensor are drastically changed upon metal complexation as a consequence of the higher electron affinity of Cu(II) with respect to C and H. Comparison of the corresponding bond populations in pure and Cu(II) doped L-alanine indicates that the Cu draws 0.11 more electron from the N than the substituted H atom. (orig.)

  1. Interactions of hydrazine, ferrous sulfamate, sodium nitrite, and nitric acid in nuclear fuel processing solutions

    International Nuclear Information System (INIS)

    Gray, L.W.

    1977-03-01

    Hydrazine and ferrous sulfamate are used as reductants in a variety of nuclear fuel processing solutions. An oxidant, normally sodium nitrite, must frequently be added to these nitric acid solutions before additional processing can proceed. The interactions of these four chemicals have been studied under a wide variety of conditions using a 2/sup p/ factorial experimental design to determine relative reaction rates for desired reactions and side reactions. Evidence for a hydrazine-stabilized, sulfamic acid--nitrous acid intermediate was obtained; this intermediate can hydrolyze to ammonia or decompose to nitrogen. The oxidation of Fe 2+ by NO 2 - was shown to proceed at about the same rate as the scavenging of NO 2 - by sulfamic acid. Various side reactions are discussed

  2. Compound-nuclear tests of time reversal invariance in the nucleon-nucleon interaction

    International Nuclear Information System (INIS)

    French, J.B.; Pandey, A.; Smith, J.

    1987-01-01

    The theory for the effects of time-reversal noninvariance (TRNI) in complex systems is reviewed. Applied to the compound-nuclear data for energy-level, width and cross-section fluctuations (the latter for detailed-balance pairs of reactions proceeding through the compound nucleus) this gives bounds on multiparticle TRNI Hamiltonian matrix elements. Using a fluctuation-free form of statistical spectroscopy the results are reduced to bounds on α, the relative magnitude of the TRNI nucleon-nucleon interaction. The level and width analyses for heavy nuclei gave α ≤ 2 x 10 -3 at high (∼99%) statistical confidence; preliminary calculations for detailed balance with 24 Mg(α,p) 27 Al and its inverse gives α ≤ 4 x 10 -3 at the same high confidence, but ≤0.2 x 10 -3 at 80% confidence. Suggestions are made about experiments which should yield sharper bounds. 28 refs., 1 tab

  3. Nuclear interactions of super high energy cosmic-rays observed by mountain emulsion chambers

    International Nuclear Information System (INIS)

    1981-01-01

    Here is presented a summary of joint discussions on the results of three mountain experiments with large-scale emulsion chambers, at Pamir, Mt. Fuji and Chacaltaya. The observation covers gamma-quanta, hadrons and their clusters (called ''families''). Following topics are covered concerning on characteristics of nuclear interactions in energy region of 10 14 - 10 16 eV: 1) rapid dissipation seen in atmospheric diffusion of high energy cosmic-rays, 2) multiplicity and p sub(t) increase in produced pimesons in the fragmentation region, 3) existence of large p sub(t) jets, 4) extremely-hadron-rich family of Centauro type, 5) exotic phenomena at extremely high energy region beyond 10 16 eV. (author)

  4. Theoretical investigation of nuclear quadrupole interactions in DNA at first-principles level

    Energy Technology Data Exchange (ETDEWEB)

    Mahato, Dip N. [State University of New York at Albany, Department of Physics (United States); Dubey, Archana [University of Central Florida, Department of Physics (United States); Pink, R. H. [State University of New York at Albany, Department of Physics (United States); Scheicher, R. H. [Uppsala University, Condensed Matter Theory Group, Department of Physics and Materials Science (Sweden); Badu, S. R. [State University of New York at Albany, Department of Physics (United States); Nagamine, K. [University of California at Riverside, Department of Physics (United States); Torikai, E. [Yamanashi University, Department of Electrical Engineering (Japan); Saha, H. P.; Chow, Lee [University of Central Florida, Department of Physics (United States); Huang, M. B. [State University of New York at Albany, College of Nanoscale Science and Engineering (United States); Das, T. P., E-mail: tpd56@albany.edu [State University of New York at Albany, Department of Physics (United States)

    2008-01-15

    We have studied the nuclear quadrupole interactions (NQI) of the {sup 14}N, {sup 17}O and {sup 2}H nuclei in the nucleobases cytosine, adenine, guanine and thymine in the free state as well as when they are bonded to the sugar ring in DNA, simulated through a CH{sub 3} group attached to the nucleobases. The nucleobase uracil, which replaces thymine in RNA, has also been studied. Our results show that there are substantial indirect effects of the bonding with the sugar group in the nucleic acids on the NQI parameters e{sup 2}qQ/h and {eta}. It is hoped that measurements of these NQI parameters in DNA will be available in the future to compare with our predictions. Our results provide the conclusion that for any property dependent on the electronic structures of the nucleic acids, the effects of the bonding between the nucleobases and the nucleic acid backbones have to be included.

  5. Nuclear interactions between cosmic radiation and interstellar gas, and nucleosynthesis of lithium, beryllium, and boron

    International Nuclear Information System (INIS)

    Meneguzzi, Maurice.

    1975-01-01

    The effects of nuclear interactions between the nuclei of cosmic radiation and those of interstellar gas were studied. The variation in the chemical composition of cosmic radiation with energy shows that the quantity of matter it passes through decreases between 1 and 100GeV/nucleon from 6 to 1g/cm 2 approximately. The chemical and isotopic composition for C, N and O suggests that the relative abundances of these nuclei at the source are much the same as the universal abundances except for the ratio C/O, higher by about a factor 1.5 in cosmic radiation sources. The enrichment of interstellar gas in light elements Li, Be and B was calculated. The value obtained accounts well for the universal abundances of the four isotopes 6 Li, 9 Be, 10 B, 11 B independently of the model used. It may be assumed that large fluxes of low-energy cosmic rays exist in the remains of supernovae and that 7 Li is produced in these objects and then spread out in the galaxy. These objects could be extended sources of nuclear γ's, which are observable, but the same process proves unable to produce sufficient quantities of the very heavy proton-rich elements of dubious origin. Inelastic collisions or spallation reactions between cosmic and interstellar gas nuclei induce a quantity of nuclear γ ray emission not necessarily undetectable. The position flux of a few MeV from the β + disintegration of unstable spallation products is too low on the other hand to give an estimate of the low-energy cosmic radiation flux in the interstellar medium [fr

  6. Study on the analytical methods to evaluate the interaction effects of embedded nuclear power plants

    International Nuclear Information System (INIS)

    Fukuzawa, R.; Chiba, O.; Tohdo, M.; Hatori, T.

    1987-01-01

    For the seismic response analyses of nuclear power plants which are more or less embedded into soil medium, it is very important to evaluate the interactive effects on the interface between soil and foundation wall, such as wave propagation to infinity radiated from the side wall. The methods generally used in these analyses can be classified into the two basic procedures. One is the direct procedure in which a structure and soil are medeled together into finite elements or beam elements having the quiet boundary; transmitting boundary, non-reflecting boundary. The other is the substructure procedure in which the computational procedure is divided into two steps. In the first step the behavior of massless foundation due to an external force and seismic motion under the assumption as rigid foundation is analyzed, and the results are represented by impedance functions and foundation input motions. Using the results, the structural response analyses are performed. Taking the substructure procedure for seismic response analyses of embedded nuclear power plants, it is the purpose of this paper to present the features of solutions on impedance functions and foundation input motions obtained by various methods such as 3- or 2-dimensional approach, and their influences on structural responses

  7. The nuclear interaction analysis methods for diagnostics of high power ion beam technologies

    Energy Technology Data Exchange (ETDEWEB)

    Ryzhkov, V A; Grushin, I I; Remnev, G E [Nuclear Physics Inst., Tomsk (Russian Federation)

    1997-12-31

    The complex of Nuclear Interaction Analysis Methods including charged particle activation analysis (CPAA and HIAA), spectrometry of ion induced gamma-emission (PIGE and HIIGE) , characteristic X-ray emission (PIXE), and Rutherford Backscattering Spectrometry (RBS), have been used for diagnostics of the High Power Ion Beam (HPIB) assisted technologies. Accelerated ion beams from the EG-2.5 electrostatic generator and U-120 cyclotron were used for implementation of the techniques. The complex allows a lot of problems of elemental and isotopic analysis to be addressed. First, it is the determination of micro- and macrocomponents of modified materials; second, determination of surface density of thin films, multilayers and coatings, total surface gaseous contamination and amounts of the elements implanted in specimens; third, measurement of concentration depth profiles of the elements. Experiments have shown that the preferable application of nuclear analysis methods allows us to avoid the considerable errors arising when the concentration depth profiles of elements are measured by SIMS or AES in studies of mass transfer processes induced by HPIBs. (author). 1 tab., 2 figs., 3 refs.

  8. Chemical and mineralogical aspects of water-bentonite interaction in nuclear fuel disposal conditions

    International Nuclear Information System (INIS)

    Melamed, A.; Pitkaenen, P.

    1996-01-01

    In the field of nuclear fuel disposal, bentonite has been selected as the principal sealing and buffer material for placement around waste canisters, forming both a mechanical and chemical barrier between the radioactive waste and the surrounding ground water. Ion exchange and mineral alteration processes were investigated in a laboratory study of the long-term interaction between compacted Na-bentonite (Volclay MX-80) and ground water solutions, conducted under simulated nuclear fuel disposal conditions. The possible alteration of montmorillonite into illite has been a major object of the mineralogical study. However, no analytical evidence was found, that would indicate the formation of this non-expandable clay type. Apparently, the change of montmorillonite from Na- to Ca-rich was found to be the major alteration process in bentonite. In the water, a concentration decrease in Ca, Mg, and K, and an increase in Na, HCO 3 and SO 4 were recorded. The amount of calcium ions available in the water was considered insufficient to account for the recorded formation of Ca-montmorillonite. It is therefore assumed that the accessory Ca-bearing minerals in bentonite provide the fundamental source of these cations, which exchange with sodium during the alteration process. (38 refs.)

  9. Myofascial force transmission causes interaction between adjacent muscles and connective tissue: Effects of blunt dissection and compartmental fasciotomy on length force characteristics of rat extensor digitorum longus muscle

    NARCIS (Netherlands)

    Huijing, P.A.J.B.M.; Baan, G.C.

    2001-01-01

    Muscles within the anterior tibial compartment (extensor digitorum longus: EDL. tibialis anterior: TA, and extensor hallucis longus muscles: EHL) and within the peroneal compartment were excited simultaneously and maximally. The ankle joint was fixed kept at 90°. For EDL length force characteristics

  10. Skyrme's interaction beyond the mean-field. The DGCM+GOA Hamiltonian of nuclear quadrupole motion

    International Nuclear Information System (INIS)

    Kluepfel, Peter

    2008-01-01

    This work focuses on the microscopic description of nuclear collective quadrupole motion within the framework of the dynamic Generator-Coordinate-Method(DGCM)+Gaussian-Overlap-Approximation(GOA). Skyrme-type effective interactions are used as the fundamental many-particle interaction. Starting from a rotational invariant, polynomial and topologic consistent formulation of the GCM+GOA Hamiltonian an interpolation scheme for the collective masses and potential is developed. It allows to define the collective Hamiltonian of fully triaxial collective quadrupole dynamics from a purely axial symmetric configuration space. The substantial gain in performance allows the self-consistent evaluation of the dynamic quadrupole mass within the ATDHF-cranking model. This work presents the first large-scale analysis of quadrupole correlation energies and lowlying collective states within the DGCM+GOA model. Different Skyrme- and pairing interactions are compared from old standards up to more recent parameterizations. After checking the validity of several approximations to the DGCM+GOA model - both on the mean-field and the collective level - we proceed with a detailed investigation of correlation effects along the chains of semi-magic isotopes and isotones. This finally allows to define a set of observables which are hardly affected by collective correlations. Those observables were used for a refit of a Skyrme-type effective interaction which is expected to cure most of the problems of the recent parameterizations. Preparing further work, estimates for the correlated ground state energy are proposed which can be evaluated directly from the mean-field model. (orig.)

  11. Skyrme's interaction beyond the mean-field. The DGCM+GOA Hamiltonian of nuclear quadrupole motion

    Energy Technology Data Exchange (ETDEWEB)

    Kluepfel, Peter

    2008-07-29

    This work focuses on the microscopic description of nuclear collective quadrupole motion within the framework of the dynamic Generator-Coordinate-Method(DGCM)+Gaussian-Overlap-Approximation(GOA). Skyrme-type effective interactions are used as the fundamental many-particle interaction. Starting from a rotational invariant, polynomial and topologic consistent formulation of the GCM+GOA Hamiltonian an interpolation scheme for the collective masses and potential is developed. It allows to define the collective Hamiltonian of fully triaxial collective quadrupole dynamics from a purely axial symmetric configuration space. The substantial gain in performance allows the self-consistent evaluation of the dynamic quadrupole mass within the ATDHF-cranking model. This work presents the first large-scale analysis of quadrupole correlation energies and lowlying collective states within the DGCM+GOA model. Different Skyrme- and pairing interactions are compared from old standards up to more recent parameterizations. After checking the validity of several approximations to the DGCM+GOA model - both on the mean-field and the collective level - we proceed with a detailed investigation of correlation effects along the chains of semi-magic isotopes and isotones. This finally allows to define a set of observables which are hardly affected by collective correlations. Those observables were used for a refit of a Skyrme-type effective interaction which is expected to cure most of the problems of the recent parameterizations. Preparing further work, estimates for the correlated ground state energy are proposed which can be evaluated directly from the mean-field model. (orig.)

  12. Pairwise additivity in the nuclear magnetic resonance interactions of atomic xenon.

    Science.gov (United States)

    Hanni, Matti; Lantto, Perttu; Vaara, Juha

    2009-04-14

    Nuclear magnetic resonance (NMR) of atomic (129/131)Xe is used as a versatile probe of the structure and dynamics of various host materials, due to the sensitivity of the Xe NMR parameters to intermolecular interactions. The principles governing this sensitivity can be investigated using the prototypic system of interacting Xe atoms. In the pairwise additive approximation (PAA), the binary NMR chemical shift, nuclear quadrupole coupling (NQC), and spin-rotation (SR) curves for the xenon dimer are utilized for fast and efficient evaluation of the corresponding NMR tensors in small xenon clusters Xe(n) (n = 2-12). If accurate, the preparametrized PAA enables the analysis of the NMR properties of xenon clusters, condensed xenon phases, and xenon gas without having to resort to electronic structure calculations of instantaneous configurations for n > 2. The binary parameters for Xe(2) at different internuclear distances were obtained at the nonrelativistic Hartree-Fock level of theory. Quantum-chemical (QC) calculations at the corresponding level were used to obtain the NMR parameters of the Xe(n) (n = 2-12) clusters at the equilibrium geometries. Comparison of PAA and QC data indicates that the direct use of the binary property curves of Xe(2) can be expected to be well-suited for the analysis of Xe NMR in the gaseous phase dominated by binary collisions. For use in condensed phases where many-body effects should be considered, effective binary property functions were fitted using the principal components of QC tensors from Xe(n) clusters. Particularly, the chemical shift in Xe(n) is strikingly well-described by the effective PAA. The coordination number Z of the Xe site is found to be the most important factor determining the chemical shift, with the largest shifts being found for high-symmetry sites with the largest Z. This is rationalized in terms of the density of virtual electronic states available for response to magnetic perturbations.

  13. Influence of a doping by Al stainless steel on kinetics and character of interaction with the metallic nuclear fuel

    Science.gov (United States)

    Nikitin, S. N.; Shornikov, D. P.; Tarasov, B. A.; Baranov, V. G.

    2016-04-01

    Metallic nuclear fuel is a perspective kind of fuel for fast reactors. In this paper we conducted a study of the interaction between uranium-molybdenum alloy and ferritic- martensitic steels with additions of aluminum at a temperature of 700 ° C for 25 hours. The rate constants of the interaction layer growth at 700 °C is about 2.8.10-14 m2/s. It is established that doping Al stainless steel leads to decrease in interaction with uranium-molybdenum alloys. The phase composition of the interaction layer is determined.

  14. Interaction between a plasma membrane-localized ankyrin-repeat protein ITN1 and a nuclear protein RTV1

    Energy Technology Data Exchange (ETDEWEB)

    Sakamoto, Hikaru [Department of Bioproduction, Faculty of Bioindustry, Tokyo University of Agriculture, 196 Yasaka, Abashiri-shi, Hokkaido 093-2422 (Japan); Sakata, Keiko; Kusumi, Kensuke [Department of Biology, Faculty of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581 (Japan); Kojima, Mikiko; Sakakibara, Hitoshi [RIKEN Plant Science Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045 (Japan); Iba, Koh, E-mail: koibascb@kyushu-u.org [Department of Biology, Faculty of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581 (Japan)

    2012-06-29

    Highlights: Black-Right-Pointing-Pointer ITN1, a plasma membrane ankyrin protein, interacts with a nuclear DNA-binding protein RTV1. Black-Right-Pointing-Pointer The nuclear transport of RTV1 is partially inhibited by interaction with ITN1. Black-Right-Pointing-Pointer RTV1 can promote the nuclear localization of ITN1. Black-Right-Pointing-Pointer Both overexpression of RTV1 and the lack of ITN1 increase salicylic acids sensitivity in plants. -- Abstract: The increased tolerance to NaCl 1 (ITN1) protein is a plasma membrane (PM)-localized protein involved in responses to NaCl stress in Arabidopsis. The predicted structure of ITN1 is composed of multiple transmembrane regions and an ankyrin-repeat domain that is known to mediate protein-protein interactions. To elucidate the molecular functions of ITN1, we searched for interacting partners using a yeast two-hybrid assay, and a nuclear-localized DNA-binding protein, RTV1, was identified as a candidate. Bimolecular fluorescence complementation analysis revealed that RTV1 interacted with ITN1 at the PM and nuclei in vivo. RTV1 tagged with red fluorescent protein localized to nuclei and ITN1 tagged with green fluorescent protein localized to PM; however, both proteins localized to both nuclei and the PM when co-expressed. These findings suggest that RTV1 and ITN1 regulate the subcellular localization of each other.

  15. Seismic sensitivity study of a generic CANDU nuclear power plant: Soil-structure interaction

    International Nuclear Information System (INIS)

    Lee, L.S.S.; Duff, C.G.

    1983-01-01

    The seismic sensitivity and capability study for a generic CANDU Plant is part of an overall development program of design standardization. The purpose of this paper is to investigate the sensitivities of structural responses and floor response spectra (FRS) to variations of structural and soil parameters. In the seismic design standardization, a wide range of soil conditions is considered and the envelopes of the resulting site spectra (soil-structure interaction effect) are then used for the design of the generic plant. The nuclear island structures considered herein have different relative stiffness and one of them has two layout/structure schemes: one is relatively flexible and the other is moderately stiff. In the preliminary phase of the seismic sensitivity study presented hereby, the soil-structure interaction seismic analysis is based on the half-space modelling (soil-spring lumped-mass) method and the response spectrum method for the seismic responses. Distinct patterns and sensitivity of the site spectrum analysis for structure schemes of different relative stiffness and for different structural elevations are observed and discussed. (orig.)

  16. Nonlinear seismic soil-structure interaction analysis of nuclear power plant structures

    International Nuclear Information System (INIS)

    Khanna, J.K.; Setlur, A.V.; Pathak, D.V.

    1977-01-01

    The heterogeneous and nonlinear soil medium and the detailed three-dimensional structure are synthesized to determine the seismic response to soil-structure systems. The approach is particularly attractive in a design office environment since it: a) leads to interactive motion at the soil-structure interface; b) uses existing public domain programs such as SAPIV, LUSH and FLUSH with marginal modifications; and c) meets current regulatory requirements for soil-structure interaction analysis. Past methods differ from each other depending on the approach adopted for soil and structure representations and procedures for solving the governing differential equations. Advantages and limitations of these methods are reviewed. In the current approach, the three-dimensional structure is represented by the dynamic characteristics of its fixed base condition. This representation is ideal when structures are designed to be within elastic range. An important criterion is the design of the nuclear power plant structures. Model damping coefficients are varied to reflect the damping properties of different structural component materials. The detailed structural model is systematically reduced to reflect important dynamic behavior with simultaneous storing of intermediate information for retrieval of detailed structural response. Validity of the approach has been established with simple numerical experiments. (Auth.)

  17. Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen

    International Nuclear Information System (INIS)

    Oyama, Masaki; Wakasugi, Mitsuo; Hama, Takashi; Hashidume, Hatsuho; Iwakami, Yasutaka; Imai, Rika; Hoshino, Sanae; Morioka, Hiroshi; Ishigaki, Yasuhito; Nikaido, Osamu; Matsunaga, Tsukasa

    2004-01-01

    Thymine glycol (Tg) is one of predominant oxidative DNA lesions caused by ionizing radiation and other oxidative stresses. Human NTH1 is a bifunctional enzyme with DNA glycosylase and AP lyase activities and removes Tg as the first step of base excision repair (BER). We have searched for the factors interacting with NTH1 by using a pull-down assay and found that GST-NTH1 fusion protein precipitates proliferating cell nuclear antigen (PCNA) and p53 as well as XPG from human cell-free extracts. GST-NTH1 also bound to recombinant FLAG-tagged XPG, PCNA, and (His) 6 -tagged p53 proteins, indicating direct protein-protein interaction between those proteins. Furthermore, His-p53 and FLAG-XPG, but not PCNA, stimulated the Tg DNA glycosylase/AP lyase activity of GST-NTH1 or NTH1. These results provide an insight into the positive regulation of BER reaction and also suggest a possible linkage between BER of Tg and other cellular mechanisms

  18. Mathematical modelling of thermal-plume interaction at Waterford Nuclear Power Station

    International Nuclear Information System (INIS)

    Tsai, S.Y.H.

    1981-01-01

    The Waldrop plume model was used to analyze the mixing and interaction of thermal effluents in the Mississippi River resulting from heated-water discharges from the Waterford Nuclear Power Station Unit 3 and from two nearby fossil-fueled power stations. The computer program of the model was modified and expanded to accommodate the multiple intake and discharge boundary conditions at the Waterford site. Numerical results of thermal-plume temperatures for individual and combined operation of the three power stations were obtained for typical low river flow (200,000 cfs) and maximum station operating conditions. The predicted temperature distributions indicated that the surface jet discharge from Waterford Unit 3 would interact with the thermal plumes produced by the two fossil-fueled stations. The results also showed that heat recirculation between the discharge of an upstream fossil-fueled plant and the intake of Waterford Unit 3 is to be expected. However, the resulting combined temperature distributions were found to be well within the thermal standards established by the state of Louisiana

  19. iNR-Drug: predicting the interaction of drugs with nuclear receptors in cellular networking.

    Science.gov (United States)

    Fan, Yue-Nong; Xiao, Xuan; Min, Jian-Liang; Chou, Kuo-Chen

    2014-03-19

    Nuclear receptors (NRs) are closely associated with various major diseases such as cancer, diabetes, inflammatory disease, and osteoporosis. Therefore, NRs have become a frequent target for drug development. During the process of developing drugs against these diseases by targeting NRs, we are often facing a problem: Given a NR and chemical compound, can we identify whether they are really in interaction with each other in a cell? To address this problem, a predictor called "iNR-Drug" was developed. In the predictor, the drug compound concerned was formulated by a 256-D (dimensional) vector derived from its molecular fingerprint, and the NR by a 500-D vector formed by incorporating its sequential evolution information and physicochemical features into the general form of pseudo amino acid composition, and the prediction engine was operated by the SVM (support vector machine) algorithm. Compared with the existing prediction methods in this area, iNR-Drug not only can yield a higher success rate, but is also featured by a user-friendly web-server established at http://www.jci-bioinfo.cn/iNR-Drug/, which is particularly useful for most experimental scientists to obtain their desired data in a timely manner. It is anticipated that the iNR-Drug server may become a useful high throughput tool for both basic research and drug development, and that the current approach may be easily extended to study the interactions of drug with other targets as well.

  20. Experimental studies of thermal and chemical interactions between oxide and silicide nuclear fuels with water

    Energy Technology Data Exchange (ETDEWEB)

    farahani, A.A.; Corradini, M.L. [Univ. of Wisconsi, Madison, WI (United States)

    1995-09-01

    Given some transient power/cooling mismatch is a nuclear reactor and its inability to establish the necessary core cooling, energetic fuel-coolant interactions (FCI`s commonly called `vapor explosions`) could occur as a result of the core melting and coolant contact. Although a large number of studies have been done on energetic FCI`s, very few experiments have been performed with the actual fuel materials postulated to be produced in severe accidents. Because of the scarcity of well-characterized FCI data for uranium allows in noncommercial reactors (cermet and silicide fuels), we have conducted a series of experiments to provide a data base for the foregoing materials. An existing 1-D shock-tube facility was modified to handle depleted radioactive materials (U{sub 3}O{sub 8}-Al, and U{sub 3}Si{sub 2}-Al). Our objectives have been to determine the effects of the initial fuel composition and temperature and the driving pressure (triggering) on the explosion work output, dynamic pressures, transient temperatures, and the hydrogen production. Experimental results indicate limited energetics, mainly thermal interactions, for these fuel materials as compared to aluminum where more chemical reactions occur between the molten aluminum and water.

  1. Team interaction skills evaluation criteria for nuclear power plant control room operators

    International Nuclear Information System (INIS)

    Montgomery, J.C.; Hauth, J.T.

    1991-01-01

    Team interaction skills are an essential aspect of safe nuclear power plant control room operations. Previous research has shown that, when a group works together, rather than as individuals, more effective operations are possible. However, little research has addressed how such team interaction skills can be measured. In this study rating scales were developed specifically for such a measurement purpose. Dimensions of team skill performance were identified from previous research and experience in the area, incorporating the input of Pacific Northwest Laboratory (PNL) contract operator licensing examiners. Rating scales were developed on the basis of these dimensions, incorporating a modified Behaviorally Anchored Rating Scale (BARS) as well as Behavioral Frequency formats. After a pilot-testing/revision process, rating data were collected using 11 control room crews responding to simulator scenarios at a boiling water and a pressurized water reactor. Statistical analyses of the resulting data revealed moderate inter-rater reliability using the Behavioral Frequency scales, relatively low inter-rater reliability using the BARS, and moderate support for convergent and discriminant validity of the scales. It was concluded that the scales show promise psychometrically and in terms of user acceptability, but that additional scale revision is needed before field implementation. Recommendations for scale revision and directions for future research were presented

  2. Analytic nuclear forces and molecular properties from full configuration interaction quantum Monte Carlo

    International Nuclear Information System (INIS)

    Thomas, Robert E.; Overy, Catherine; Opalka, Daniel; Alavi, Ali; Knowles, Peter J.; Booth, George H.

    2015-01-01

    Unbiased stochastic sampling of the one- and two-body reduced density matrices is achieved in full configuration interaction quantum Monte Carlo with the introduction of a second, “replica” ensemble of walkers, whose population evolves in imaginary time independently from the first and which entails only modest additional computational overheads. The matrices obtained from this approach are shown to be representative of full configuration-interaction quality and hence provide a realistic opportunity to achieve high-quality results for a range of properties whose operators do not necessarily commute with the Hamiltonian. A density-matrix formulated quasi-variational energy estimator having been already proposed and investigated, the present work extends the scope of the theory to take in studies of analytic nuclear forces, molecular dipole moments, and polarisabilities, with extensive comparison to exact results where possible. These new results confirm the suitability of the sampling technique and, where sufficiently large basis sets are available, achieve close agreement with experimental values, expanding the scope of the method to new areas of investigation

  3. Interaction of selected actinides (U, Cm) with bacteria relevant to nuclear waste disposal

    Energy Technology Data Exchange (ETDEWEB)

    Luetke, Laura

    2013-07-01

    To assess the safety of a site destined for storage of nuclear waste enhanced research effort is demanded to investigate the complex interactions of released radionuclides with parts of the environment that includes indigenous microorganisms. This work aimed at assessing the interactions of two bacterial strains with the actinides uranium and curium with a focus on thermodynamics to provide stability constants of the actinide bacteria species formed usable for modelling the distribution of these actinides in the environment. The influences of Pseudomonas fluorescens (CCUG 32456A) isolated from the granitic aquifers at Aespoe(Sweden) and a novel isolate from Mont Terri Opalinus clay (Switzerland), Paenibacillus sp. MT-2.2, were investigated. A combined approach using microbiological and spectroscopic techniques as well as potentiometry was employed to characterize the U(VI) and Cm(III) binding onto the cell surface functional groups structurally and thermodynamically. Further, due to its similar ionic radius to Cm(III) also Eu(III) was studied as non-radioactive analog.

  4. iNR-Drug: Predicting the Interaction of Drugs with Nuclear Receptors in Cellular Networking

    Directory of Open Access Journals (Sweden)

    Yue-Nong Fan

    2014-03-01

    Full Text Available Nuclear receptors (NRs are closely associated with various major diseases such as cancer, diabetes, inflammatory disease, and osteoporosis. Therefore, NRs have become a frequent target for drug development. During the process of developing drugs against these diseases by targeting NRs, we are often facing a problem: Given a NR and chemical compound, can we identify whether they are really in interaction with each other in a cell? To address this problem, a predictor called “iNR-Drug” was developed. In the predictor, the drug compound concerned was formulated by a 256-D (dimensional vector derived from its molecular fingerprint, and the NR by a 500-D vector formed by incorporating its sequential evolution information and physicochemical features into the general form of pseudo amino acid composition, and the prediction engine was operated by the SVM (support vector machine algorithm. Compared with the existing prediction methods in this area, iNR-Drug not only can yield a higher success rate, but is also featured by a user-friendly web-server established at http://www.jci-bioinfo.cn/iNR-Drug/, which is particularly useful for most experimental scientists to obtain their desired data in a timely manner. It is anticipated that the iNR-Drug server may become a useful high throughput tool for both basic research and drug development, and that the current approach may be easily extended to study the interactions of drug with other targets as well.

  5. Experimental and analytical studies on soil-structure interaction behavior of nuclear reactor building

    International Nuclear Information System (INIS)

    Tsushima, Y.

    1978-01-01

    The purpose of this study is to estimate damping effects due to soil-structure interaction by the dissipation of vibrational energy to the ground through the foundation in a building with a short fundamental period such as a nuclear reactor building. The author performed experimental and analytical studies on the vibrational characteristics of model steel structures ranging from one to four stories high erected on the rigid base and located on soil, which are simulated from the vibrational characteristics of a prototype reactor building: the former study is to obtain damping effects due to inner friction of steel frames and the latter to obtain radiation damping effects due to soil-structure interaction. The author also touches upon the results of experiments performed on a BWR-type reactor building in 1974, which showed damping ratios higher than 20% of those in fundamental modes. Then the author attempts to estimate the damping effects of the reactor building by his own method proposed in the report. Through these studies the author finally concludes that the experimental damping effects are remarkable in the lower modes by the energy dissipation and the analytical results show a fairly good fit to the experimental ones

  6. Hyperfine electron-nuclear interactions in the frame of the Density Functional and of the Density Matrix Methods

    International Nuclear Information System (INIS)

    Pavlov, R.L.; Pavlov, L.I.; Raychev, P.P.; Garistov, V.P.; Dimitrova-Ivanovich, M.

    2002-01-01

    The matrix elements and expectation values of the hyperfine interaction operators are presented in a form suitable for numerical implementation in density matrix methods. The electron-nuclear spin-spin (dipolar and contact) interactions are considered, as well as the interaction between nuclear spin and electron-orbital motions. These interactions from the effective Breit-Pauli Hamiltonian determine the hyperfine structure in ESR spectra and contribute to chemical shifts in NMR. Applying the Wigner-Eckart theorem in the irreducible tensor-operator technique and the spin-space separation scheme, the matrix elements and expectation values of these relativistic corrections are expressed in analytical form. The final results are presented as products, or sums of products, of factors determined by the spin and (or) angular momentum symmetry and a spatial part determined by the action of the symmetrized tensor-operators on the normalized matrix or function of the spin or charge distribution.

  7. RanGTP-mediated nuclear export of karyopherin α involves its interaction with the nucleoporin Nup153

    OpenAIRE

    Moroianu, Junona; Blobel, Günter; Radu, Aurelian

    1997-01-01

    Using binding assays, we discovered an interaction between karyopherin α2 and the nucleoporin Nup153 and mapped their interacting domains. We also isolated a 15-kDa tryptic fragment of karyopherin β1, termed β1*, that contains a determinant for binding to the peptide repeat containing nucleoporin Nup98. In an in vitro assay in which export of endogenous nuclear karyopherin α from nuclei of digitonin-permeabilized cells was quantitatively monitored by indirect immunofluorescence with anti-kary...

  8. Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site.

    Science.gov (United States)

    Ryan, Gemma M; McLeod, Victoria M; Mehta, Dharmini; Kelly, Brian D; Stanislawski, Pauline C; Owen, David J; Kaminskas, Lisa M; Porter, Christopher J H

    2017-11-01

    Drug conjugation to dendrimer-based delivery systems has been shown to enhance delivery to the lymphatic system after subcutaneous administration. Dendrimer interaction with components of the interstitium at the injection site, however, may prevent drainage from the injection site. The current study sought to vary the length of a linker employed to conjugate methotrexate (MTX) to a PEGylated dendrimer, in an attempt to reduce MTX interaction with interstitial binding sites and enhance lymphatic drainage. Dendrimers with shorter linkers resulted in higher lymphatic drainage, presumably via shielding of interaction sites by the PEG mantle, but were not retained in lymph nodes. Improved drainage of dendrimers with longer linkers was achieved through coadministration with dextran to mask interactions at the injection site while maintaining retention within the node. Enhanced drug exposure to the lymph node has the potential to enhance the treatment of lymph-node resident cancer metastases. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Nuclear physics research front line by K computer. Elucidation of inter-hadron interactions by lattice QCD simulation

    International Nuclear Information System (INIS)

    Doi, Takumi

    2013-01-01

    Research of nuclear forces by lattice QCD including inter-hadron interactions is presented. Determination of nuclear forces based on the first principle of QCD means to give underpinning of nuclear physics from the elementary particle standard model. Determining the unknown interactions such as hyperon forces or three-body ones gives large impacts not only to the nuclear physics but also to the universe or astrophysics. In this paper, the most up-to-date achievements as well as the scientific visions of future by using K computer is introduced. The nuclear potential is shown to be determined by the first principle simulation based on the purely fundamental theory without using any input from experiments. When this research is completed, nuclear physics is consolidated in the frame of standard model of elementary particles. The formulation of nuclear potentials was though very problematic but solved by using HAL method. The way to use Nambu-Bethe-Salpeter wave functions to go to the QCD is explained. The results of the lattice QCD simulation are shown about the nuclear force potential of 1 S 0 channel and the scattering phase differences. About the hyperon forces, computer results from the limit of flavor SU(3) where the masses of u, d and s quarks are equal are introduced here. Further studies using different quark masses are necessary and calculation taking the SU(3) breaking into consideration is in progress. The calculation result of triple proton channel is shown as an example of three-body forth, which is another important nuclear force. To let the lattice QCD exert the predicting ability further steps are left. Calculations on real quark masses are considered especially important as the future problem. Confronting the large problem of hadron many-body systems, K computer is the biggest challenging force as well as the new formalism of HAL QCD and Unified Contraction Algorithm (UCA). (S. Funahashi)

  10. ATM Protein Physically and Functionally Interacts with Proliferating Cell Nuclear Antigen to Regulate DNA Synthesis*

    Science.gov (United States)

    Gamper, Armin M.; Choi, Serah; Matsumoto, Yoshihiro; Banerjee, Dibyendu; Tomkinson, Alan E.; Bakkenist, Christopher J.

    2012-01-01

    Ataxia telangiectasia (A-T) is a pleiotropic disease, with a characteristic hypersensitivity to ionizing radiation that is caused by biallelic mutations in A-T mutated (ATM), a gene encoding a protein kinase critical for the induction of cellular responses to DNA damage, particularly to DNA double strand breaks. A long known characteristic of A-T cells is their ability to synthesize DNA even in the presence of ionizing radiation-induced DNA damage, a phenomenon termed radioresistant DNA synthesis. We previously reported that ATM kinase inhibition, but not ATM protein disruption, blocks sister chromatid exchange following DNA damage. We now show that ATM kinase inhibition, but not ATM protein disruption, also inhibits DNA synthesis. Investigating a potential physical interaction of ATM with the DNA replication machinery, we found that ATM co-precipitates with proliferating cell nuclear antigen (PCNA) from cellular extracts. Using bacterially purified ATM truncation mutants and in vitro translated PCNA, we showed that the interaction is direct and mediated by the C terminus of ATM. Indeed, a 20-amino acid region close to the kinase domain is sufficient for strong binding to PCNA. This binding is specific to ATM, because the homologous regions of other PIKK members, including the closely related kinase A-T and Rad3-related (ATR), did not bind PCNA. ATM was found to bind two regions in PCNA. To examine the functional significance of the interaction between ATM and PCNA, we tested the ability of ATM to stimulate DNA synthesis by DNA polymerase δ, which is implicated in both DNA replication and DNA repair processes. ATM was observed to stimulate DNA polymerase activity in a PCNA-dependent manner. PMID:22362778

  11. Interaction between lidocaine hydrochloride (with and without adrenaline) and various irrigants: A nuclear magnetic resonance analysis.

    Science.gov (United States)

    Vidhya, Nirmal; Karthikeyan, Balasubramanian Saravana; Velmurugan, Natanasabapathy; Abarajithan, Mohan; Nithyanandan, Sivasankaran

    2014-05-01

    Interaction between local anesthetic solution, lidocaine hydrochloride (with and without adrenaline), and root canal irrigants such as sodium hypochlorite (NaOCl), ethylene diamine tetra-acetic acid (EDTA), and chlorhexidine (CHX) has not been studied earlier. Hence, the purpose of this in vitro study was to evaluate the chemical interaction between 2% lidocaine hydrochloride (with and without adrenaline) and commonly used root canal irrigants, NaOCl, EDTA, and CHX. SAMPLES WERE DIVIDED INTO EIGHT EXPERIMENTAL GROUPS: Group I-Lidocaine hydrochloride (with adrenaline)/3% NaOCl, Group II-Lidocaine hydrochloride (with adrenaline)/17% EDTA, Group III- Lidocaine hydrochloride (with adrenaline)/2% CHX, Group IV-Lidocaine hydrochloride (without adrenaline)/3% NaOCl, Group V-Lidocaine hydrochloride (without adrenaline)/17% EDTA, Group VI-Lidocaine hydrochloride (without adrenaline)/2% CHX, and two control groups: Group VII-Lidocaine hydrochloride (with adrenaline)/deionized water and Group VIII-Lidocaine hydrochloride (without adrenaline)/deionized water. The respective solutions of various groups were mixed in equal proportions (1 ml each) and observed for precipitate formation. Chemical composition of the formed precipitate was then analysed by nuclear magnetic resonance spectroscopy (NMR) and confirmed with diazotation test. In groups I and IV, a white precipitate was observed in all the samples on mixing the respective solutions, which showed a color change to reddish brown after 15 minutes. This precipitate was then analysed by NMR spectroscopy and was observed to be 2,6-xylidine, a reported toxic compound. The experimental groups II, III, V, and VI and control groups VII and VIII showed no precipitate formation in any of the respective samples, until 2 hours. Interaction between lidocaine hydrochloride (with and without adrenaline) and NaOCl showed precipitate formation containing 2,6-xylidine, a toxic compound.

  12. Coulomb corrections to scattering length and effective radius

    International Nuclear Information System (INIS)

    Mur, V.D.; Kudryavtsev, A.E.; Popov, V.S.

    1983-01-01

    The problem considered is extraction of the ''purely nuclear'' scattering length asub(s) (corresponding to the strong potential Vsub(s) at the Coulomb interaction switched off) from the Coulomb-nuclear scattering length asub(cs), which is an object of experimental measurement. The difference between asub(s) and asub(cs) is especially large if the potential Vsub(s) has a level (real or virtual) with an energy close to zero. For this case formulae are obtained relating the scattering lengths asub(s) and asub(cs), as well as the effective radii rsub(s) and rsub(cs). The results are extended to states with arbitrary angular momenta l. It is shown that the Coulomb correction is especially large for the coefficient with ksup(2l) in the expansion of the effective radius; in this case the correction contains a large logarithm ln(asub(B)/rsub(0)). The Coulomb renormalization of other terms in the effective radius espansion is of order (rsub(0)/asub(B)), where r 0 is the nuclear force radius, asub(B) is the Bohr radius. The obtained formulae are tried on a number of model potentials Vsub(s), used in nuclear physics

  13. Nuclear attenuation of fast hadrons produced in charged-current ν and anti ν interactions in neon

    International Nuclear Information System (INIS)

    Burkot, W.; Coghen, T.; Czyzewski, J.

    1996-01-01

    The production of hadrons in charged-current (anti)neutrino interactions is studied with the bubble chamber BEBC exposed to the CERN (anti)neutrino wide-band beam. Fast-hadron production in a neon target is found to be attenuated as compared to that in a hydrogen target. This feature is discussed within theoretical models based on the idea of a hadron formation length. The experimental results favour the 'constituent' over the 'yo-yo' length concept, and suggest a quark cross section in the order of 3 mb. (orig.)

  14. Nucleocytoplasmic trafficking of Nipah virus W protein involves multiple discrete interactions with the nuclear import and export machinery

    International Nuclear Information System (INIS)

    Audsley, Michelle D.; Jans, David A.; Moseley, Gregory W.

    2016-01-01

    Paramyxoviruses replicate in the cytoplasm with no obvious requirement to interact with the nucleus. Nevertheless, the W protein of the highly lethal bat-borne paramyxovirus Nipah virus (NiV) is known to undergo specific targeting to the nucleus, mediated by a single nuclear localisation signal (NLS) within the C-terminal domain. Here, we report for the first time that additional sites modulate nucleocytoplasmic localisation of W. We show that the N-terminal domain interacts with importin α1 and contributes to nuclear accumulation of W, indicative of a novel N-terminal NLS. We also find that W undergoes exportin-1 mediated nuclear export, dependent on a leucine at position 174. Together, these data enable significant revision of the generally accepted model of W trafficking, with implications for understanding of the mechanisms of NiV immune evasion. - Highlights: • A new model for Nipah virus W protein nucleocytoplasmic trafficking is proposed. • Nipah W protein is shown to undergo active nuclear export via exportin-1. • Nipah W nuclear import is mediated by multiple nuclear localisation signals.

  15. Measurement of the dechanneling length for high-energy negative pions

    International Nuclear Information System (INIS)

    Scandale, W.; Losito, R.; Bagli, E.; Bandiera, L.; Dalpiaz, P.; Fiorini, M.; Guidi, V.; Mazzolari, A.; Vincenzi, D.; Della Mea, G.; Vallazza, E.; Afonin, A.G.; Chesnokov, Yu.A.; Maisheev, V.A.; Yazynin, I.A.; Kovalenko, A.D.; Taratin, A.M.; Denisov, A.S.; Gavrikov, Yu.A.; Ivanov, Yu.M.

    2013-01-01

    We studied the dechanneling length of 150 GeV/cπ − interacting with a short bent silicon crystal. Dechanneling length measures the rate and the strength of incoherent interactions of channeled particles in a crystal. The mechanism of dechanneling of negatively charged particles has been elucidated through simulation and experiment. It was found that the dechanneling length for negative particles is comparable to the nuclear dechanneling length for positive charges. Indeed, dechanneling of negative particles occurs as a result of incoherent interactions with the nuclei because the trajectories of such particles always intersect atomic planes, explaining the lower channeling efficiency for such particles. Obtained results can be useful for the design of crystals for manipulating high-energy negative particle beams through channeling

  16. Evaluation of systems interactions in nuclear power plants: Technical findings related to Unresolved Safety Issue A-17

    International Nuclear Information System (INIS)

    Thatcher, D.

    1989-05-01

    This report presents a summary of the activities related to Unresolved Safety Issue (USI)A-17, ''Systems Interactions in Nuclear Power Plants,'' and also includes the NRC staff's conclusions based on those activities. The staff's technical findings provide the framework for the final resolution of this unresolved safety issue. The final resolution will be published later as NUREG-1229. 52 refs., 4 tabs

  17. The nuclear weapons inheritance project: student-to-student dialogues and interactive peer education in disarmament activism.

    Science.gov (United States)

    Buhmann, Caecilie Böck

    2007-01-01

    The Nuclear Weapons Inheritance Project is a student run and student initiated project founded in 2001 with the purpose of increasing awareness of health effects of nuclear policies and empowering university students to take action in a local and international context. The project uses dialogues to discuss nuclear disarmament with university students and a method of interactive peer education to train new trainers. The project has met more than 1500 students in nuclear weapon states in dialogue and trained about 400 students from all over the world. This article describes the methods and results of the project and discuss how the experience of the project can be used in other projects seeking to increase awareness of a topic and to initiate action on social injustice.

  18. Liquid-phase characterization of molecular interactions in polyunsaturated and n-fatty acid methyl esters by (1)H low-field nuclear magnetic resonance.

    Science.gov (United States)

    Meiri, Nitzan; Berman, Paula; Colnago, Luiz Alberto; Moraes, Tiago Bueno; Linder, Charles; Wiesman, Zeev

    2015-01-01

    To identify and develop the best renewable and low carbon footprint biodiesel substitutes for petroleum diesel, the properties of different biodiesel candidates should be studied and characterized with respect to molecular structures versus biodiesel liquid property relationships. In our previous paper, (1)H low-field nuclear magnetic resonance (LF-NMR) relaxometry was investigated as a tool for studying the liquid-phase molecular packing interactions and morphology of fatty acid methyl esters (FAMEs). The technological potential was demonstrated with oleic acid and methyl oleate standards having similar alkyl chains but different head groups. In the present work, molecular organization versus segmental and translational movements of FAMEs in their pure liquid phase, with different alkyl chain lengths (10-20 carbons) and degrees of unsaturation (0-3 double bonds), were studied with (1)H LF-NMR relaxometry and X-ray, (1)H LF-NMR diffusiometry, and (13)C high-field NMR. Based on density values and X-ray measurements, it was proposed that FAMEs possess a liquid crystal-like order above their melting point, consisting of random liquid crystal aggregates with void spaces between them, whose morphological properties depend on chain length and degree of unsaturation. FAMEs were also found to exhibit different degrees of rotational and translational motions, which were rationalized by chain organization within the clusters, and the degree and type of molecular interactions and temperature effects. At equivalent fixed temperature differences from melting point, saturated FAME molecules were found to have similar translational motion regardless of chain length, expressed by viscosity, self-diffusion coefficients, and spin-spin (T 2) (1)H LF-NMR. T 2 distributions suggest increased alkyl chain rigidity, and reduced temperature response of the peaks' relative contribution with increasing unsaturation is a direct result of the alkyl chain's morphological packing and molecular

  19. Relativistic effects in the intermolecular interaction-induced nuclear magnetic resonance parameters of xenon dimer.

    Science.gov (United States)

    Hanni, Matti; Lantto, Perttu; Ilias, Miroslav; Jensen, Hans Jorgen Aagaard; Vaara, Juha

    2007-10-28

    Relativistic effects on the (129)Xe nuclear magnetic resonance shielding and (131)Xe nuclear quadrupole coupling (NQC) tensors are examined in the weakly bound Xe(2) system at different levels of theory including the relativistic four-component Dirac-Hartree-Fock (DHF) method. The intermolecular interaction-induced binary chemical shift delta, the anisotropy of the shielding tensor Deltasigma, and the NQC constant along the internuclear axis chi( parallel) are calculated as a function of the internuclear distance. DHF shielding calculations are carried out using gauge-including atomic orbitals. For comparison, the full leading-order one-electron Breit-Pauli perturbation theory (BPPT) is applied using a common gauge origin. Electron correlation effects are studied at the nonrelativistic (NR) coupled-cluster singles and doubles with perturbational triples [CCSD(T)] level of theory. The fully relativistic second-order Moller-Plesset many-body perturbation (DMP2) theory is used to examine the cross coupling between correlation and relativity on NQC. The same is investigated for delta and Deltasigma by BPPT with a density functional theory model. A semiquantitative agreement between the BPPT and DHF binary property curves is obtained for delta and Deltasigma in Xe(2). For these properties, the currently most complete theoretical description is obtained by a piecewise approximation where the uncorrelated relativistic DHF results obtained close to the basis-set limit are corrected, on the one hand, for NR correlation effects and, on the other hand, for the BPPT-based cross coupling of relativity and correlation. For chi( parallel), the fully relativistic DMP2 results obtain a correction for NR correlation effects beyond MP2. The computed temperature dependence of the second virial coefficient of the (129)Xe nuclear shielding is compared to experiment in Xe gas. Our best results, obtained with the piecewise approximation for the binary chemical shift combined with the

  20. Single-particle potential of the Λ hyperon in nuclear matter with chiral effective field theory NLO interactions including effects of Y N N three-baryon interactions

    Science.gov (United States)

    Kohno, M.

    2018-03-01

    Adopting hyperon-nucleon and hyperon-nucleon-nucleon interactions parametrized in chiral effective field theory, single-particle potentials of the Λ and Σ hyperons are evaluated in symmetric nuclear matter and in pure neutron matter within the framework of lowest-order Bruckner theory. The chiral NLO interaction bears strong Λ N -Σ N coupling. Although the Λ potential is repulsive if the coupling is switched off, the Λ N -Σ N correlation brings about the attraction consistent with empirical data. The Σ potential is repulsive, which is also consistent with empirical information. The interesting result is that the Λ potential becomes shallower beyond normal density. This provides the possibility of solving the hyperon puzzle without introducing ad hoc assumptions. The effects of the Λ N N -Λ N N and Λ N N -Σ N N three-baryon forces are considered. These three-baryon forces are first reduced to normal-ordered effective two-baryon interactions in nuclear matter and then incorporated in the G -matrix equation. The repulsion from the Λ N N -Λ N N interaction is of the order of 5 MeV at normal density and becomes larger with increasing density. The effects of the Λ N N -Σ N N coupling compensate the repulsion at normal density. The net effect of the three-baryon interactions on the Λ single-particle potential is repulsive at higher densities.

  1. Relationship of the vibrational frequency of the nuclear pair Mo-Cl with it electronegativity, force constant and bond length in the structural conformation of molybden dichloride

    International Nuclear Information System (INIS)

    Rodriguez S, A.; Martinez Q, E.

    1990-08-01

    The structural elucidation of the cluster hexamerico (MO 6 C1 8 ) 4+ , it has been characterized for but of twenty-five years like a conformation octahedrica of simple metallic connections. However, the determination has not been attempted of some physical characteristics of this conformation by means of measures espectroscopicas. We present the electronegatividad measures now, constant of force and it distances of connection of the nuclear couple Mo-Cl, using only their frequency vibracional taken directly of the infrared spectra. (Author)

  2. Production of a full-length infectious GFP-tagged cDNA clone of Beet mild yellowing virus for the study of plant-polerovirus interactions.

    Science.gov (United States)

    Stevens, Mark; Viganó, Felicita

    2007-04-01

    The full-length cDNA of Beet mild yellowing virus (Broom's Barn isolate) was sequenced and cloned into the vector pLitmus 29 (pBMYV-BBfl). The sequence of BMYV-BBfl (5721 bases) shared 96% and 98% nucleotide identity with the other complete sequences of BMYV (BMYV-2ITB, France and BMYV-IPP, Germany respectively). Full-length capped RNA transcripts of pBMYV-BBfl were synthesised and found to be biologically active in Arabidopsis thaliana protoplasts following electroporation or PEG inoculation when the protoplasts were subsequently analysed using serological and molecular methods. The BMYV sequence was modified by inserting DNA that encoded the jellyfish green fluorescent protein (GFP) into the P5 gene close to its 3' end. A. thaliana protoplasts electroporated with these RNA transcripts were biologically active and up to 2% of transfected protoplasts showed GFP-specific fluorescence. The exploitation of these cDNA clones for the study of the biology of beet poleroviruses is discussed.

  3. Telomere Length and Mortality

    DEFF Research Database (Denmark)

    Kimura, Masayuki; Hjelmborg, Jacob V B; Gardner, Jeffrey P

    2008-01-01

    Leukocyte telomere length, representing the mean length of all telomeres in leukocytes, is ostensibly a bioindicator of human aging. The authors hypothesized that shorter telomeres might forecast imminent mortality in elderly people better than leukocyte telomere length. They performed mortality...

  4. Dynamic interactions of components, structure, and foundation of nuclear power facilities

    International Nuclear Information System (INIS)

    Pajuhesh, J.; Hadjian, A.H.

    1977-01-01

    A solution is formulated for the dynamic analysis of structures and components with different stiffness and damping characteristics, including the consideration of soil-structure interaction effects. Composite structures are often analysed approximately, in particular with regards to damping. For example, the reactor and other equipment in nuclear power plant structures are often analysed by assuming them uncoupled from the supporting structures. To achieve a better accuracy, the coupled system is hereby analysed as a composite component-structure-soil system. Although derivation of mass and stiffness matrices for the component-structure-soil system is a simple problem, the determination of the damping characteristics of such a system is more complex. This emphasis on the proper evaluation of system damping is warranted on the grounds that, when resonance conditions occur, the response amplitude is governed to a significant degree by the system damping. The damping information is usually available for each sub-structure separately with its based fixed or devoid of rigid-body modes of motion. The rigid-body motions are often free of damping resistance but sometimes, such as in the case of soil-structure interaction, or in the case of aerodynamic resistance, are uniquely defined. The composite damping matrix for the complete structure is hereby derived from the above-mentioned information. Thus, the damping matrix is first obtained for the free-free model of each sub-structure (the model containing the structural degrees of freedom together with rigid-body modes of motion), and then the submatrices for the free-free models are assembled to form the composite damping matrix in acccordance with an assembly technique relating the sub-structure coordinates to the global coordinates of the composite structure

  5. Ex-vessel molten core debris interactions at CANDU nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, M J; Oyinloye, J O; Chambers, I [Electrowatt Consulting Engineers and Scientists, Warrington, Cheshire (United Kingdom); Scott, C K [Atlantic Nuclear Services, Fredericton, NB (Canada); Omar, A M [Atomic Energy Control Board, Ottawa, ON (Canada)

    1991-12-31

    Currently, the Atomic Energy Control Board (AECB) of Canada is sponsoring a project with a long term objective of obtaining an evaluation, independent of the industry, of the consequences to the public and the environment of postulated severe accidents at a Canadian nuclear power plant. Phase 1 of this project is a scoping study conducted to establish the relative consequences of a number of postulated event sequences. The studies in this paper model a multi-unit CANDU reactor at which pre-defined initiating events and their consequences could lead to severe core damage and relocation of the core debris onto the floor of the concrete reactor vault. Depending on the accident sequence assumptions made, an overlying pool of water may or may not be present. The US-NRC computer code CORCON Mod 2.0 was used to calculate the behaviour of the core material interacting with the concrete. The code calculates the decomposition of concrete by the molten core, and also the gases produced, which are released into the containment. The challenges to containment integrity are described, from the viewpoint of foundation decomposition and failure due to overpressure. The containment thermal-hydraulic behaviour is examined using an in-house computer code (CREM) written for this purpose. It is found that the containment envelope, in the absence of mitigating operator actions or design safety features, even for a case involving early core disassembly with the vacuum building unavailable, is unlikely to be failed within the 48 hours time frame examined. The paper identifies several areas for improvement in the models for future studies of core-concrete interactions for CANDU reactor plants. (author). 8 refs., 1 tab., 5 figs.

  6. Ex-vessel molten core debris interactions at CANDU nuclear power plants

    International Nuclear Information System (INIS)

    Lewis, M.J.; Oyinloye, J.O.; Chambers, I.; Scott, C.K.; Omar, A.M.

    1990-01-01

    Currently, the Atomic Energy Control Board (AECB) of Canada is sponsoring a project with a long term objective of obtaining an evaluation, independent of the industry, of the consequences to the public and the environment of postulated severe accidents at a Canadian nuclear power plant. Phase 1 of this project is a scoping study conducted to establish the relative consequences of a number of postulated event sequences. The studies in this paper model a multi-unit CANDU reactor at which pre-defined initiating events and their consequences could lead to severe core damage and relocation of the core debris onto the floor of the concrete reactor vault. Depending on the accident sequence assumptions made, an overlying pool of water may or may not be present. The US-NRC computer code CORCON Mod 2.0 was used to calculate the behaviour of the core material interacting with the concrete. The code calculates the decomposition of concrete by the molten core, and also the gases produced, which are released into the containment. The challenges to containment integrity are described, from the viewpoint of foundation decomposition and failure due to overpressure. The containment thermal-hydraulic behaviour is examined using an in-house computer code (CREM) written for this purpose. It is found that the containment envelope, in the absence of mitigating operator actions or design safety features, even for a case involving early core disassembly with the vacuum building unavailable, is unlikely to be failed within the 48 hours time frame examined. The paper identifies several areas for improvement in the models for future studies of core-concrete interactions for CANDU reactor plants. (author). 8 refs., 1 tab., 5 figs

  7. Interaction of Proliferating Cell Nuclear Antigen With DNA at the Single Molecule Level

    KAUST Repository

    Raducanu, Vlad-Stefan

    2016-05-01

    Proliferating cell nuclear antigen (PCNA) is a key factor involved in Eukaryotic DNA replication and repair, as well as other cellular pathways. Its importance comes mainly from two aspects: the large numbers of interacting partners and the mechanism of facilitated diffusion along the DNA. The large numbers of interacting partners makes PCNA a necessary factor to consider when studying DNA replication, either in vitro or in vivo. The mechanism of facilitated diffusion along the DNA, i.e. sliding along the duplex, reduces the six degrees of freedom of the molecule, three degrees of freedom of translation and three degrees of freedom of rotation, to only two, translation along the duplex and rotational tracking of the helix. Through this mechanism PCNA can recruit its partner proteins and localize them to the right spot on the DNA, maybe in the right spatial orientation, more effectively and in coordination with other proteins. Passive loading of the closed PCNA ring on the DNA without free ends is a topologically forbidden process. Replication factor C (RFC) uses energy of ATP hydrolysis to mechanically open the PCNA ring and load it on the dsDNA. The first half of the introduction gives overview of PCNA and RFC and the loading mechanism of PCNA on dsDNA. The second half is dedicated to a diffusion model and to an algorithm for analyzing PCNA sliding. PCNA and RFC were successfully purified, simulations and a mean squared displacement analysis algorithm were run and showed good stability and experimental PCNA sliding data was analyzed and led to parameters similar to the ones in literature.

  8. Bovine Lhx8, a Germ Cell-Specific Nuclear Factor, Interacts with Figla.

    Directory of Open Access Journals (Sweden)

    Liyuan Fu

    Full Text Available LIM homeobox 8 (Lhx8 is a germ cell-specific transcription factor essential for the development of oocytes during early oogenesis. In mice, Lhx8 deficiency causes postnatal oocyte loss and affects the expression of many oocyte-specific genes. The aims of this study were to characterize the bovine Lhx8 gene, determine its mRNA expression during oocyte development and early embryogenesis, and evaluate its interactions with other oocyte-specific transcription factors. The bovine Lhx8 gene encodes a protein of 377 amino acids. A splice variant of Lhx8 (Lhx8_v1 was also identified. The predicted bovine Lhx8 protein contains two LIM domains and one homeobox domain. However, one of the LIM domains in Lhx8_v1 is incomplete due to deletion of 83 amino acids near the N terminus. Both Lhx8 and Lhx8_v1 transcripts were only detected in the gonads but none of the somatic tissues examined. The expression of Lhx8 and Lhx8_v1 appears to be restricted to oocytes as none of the transcripts was detectable in granulosa or theca cells. The maternal Lhx8 transcript is abundant in GV and MII stage oocytes as well as in early embryos but disappear by morula stage. A nuclear localization signal that is required for the import of Lhx8 into nucleus was identified, and Lhx8 is predominantly localized in the nucleus when ectopically expressed in mammalian cells. Finally, a novel interaction between Lhx8 and Figla, another transcription factor essential for oogenesis, was detected. The results provide new information for studying the mechanisms of action for Lhx8 in oocyte development and early embryogenesis.

  9. Summary of neutron scattering lengths

    International Nuclear Information System (INIS)

    Koester, L.

    1981-12-01

    All available neutron-nuclei scattering lengths are collected together with their error bars in a uniform way. Bound scattering lengths are given for the elements, the isotopes, and the various spin-states. They are discussed in the sense of their use as basic parameters for many investigations in the field of nuclear and solid state physics. The data bank is available on magnetic tape, too. Recommended values and a map of these data serve for an uncomplicated use of these quantities. (orig.)

  10. FENDL/E-2.0. Evaluated nuclear data library of neutron-nucleus interaction cross sections and photon production cross sections and photon-atom interaction cross sections for fusion applications. Version 1, March 1997. Summary documentation

    International Nuclear Information System (INIS)

    Pashchenko, A.B.; Wienke, H.

    1998-01-01

    This document presents the description of a physical tape containing the basic evaluated nuclear data library of neutron-nucleus interaction cross sections, photon production cross sections and photon-atom interaction cross sections for fusion applications. It is part of the evaluated nuclear data library for fusion applications FENDL-2. The data are available cost-free from the Nuclear Data Section upon request. The data can also be retrieved by the user via online access through international computer networks. (author)

  11. Seismic induced nonlinear rotor-bearing-casing interaction of rotating nuclear components

    International Nuclear Information System (INIS)

    Choy, F.K.; Padovan, J.; Li, W.H.

    1989-01-01

    The study of the dynamics of turbomachinery during seismic events has been of continuous interest to both researchers and designers of large rotating equipment. Failure in such equipment, especially those associated with nuclear power generation, can lead to catastrophic consequences. Hence, there is a general trend for corporations to overdesign the equipment without any indepth understanding of the dynamical performance of the machine under extreme operating conditions. The overall objective of this paper are fourfold, namely: (1) To study the nonlinear dynamics of rotor-bearing casing system during rub interactions; (2) To examine the effects of suddenly induced imbalance and base motion in the global dynamical behavior of the system; (3) To develop engineering insights through the modal parameters in both time and frequency domain; (4) To generate signature analysis on rub forces for pattern recognition. These goals are achieved through the development of a modal impact model. Accuracy and efficiency of this transient model are maintained using a self-adaptive integration scheme

  12. Contribution to numerical and mechanical modelling of pellet-cladding interaction in nuclear reactor fuel rod

    International Nuclear Information System (INIS)

    Retel, V.

    2002-12-01

    Pressurised water reactor fuel rods (PWR) are the place of nuclear fission, resulting in unstable and radioactive elements. Today, the mechanical loading on the cladding is harder and harder and is partly due to the fuel pellet movement. Then, the mechanical behaviour of the cladding needs to be simulated with models allowing to assess realistic stress and strain fields for all the running conditions. Besides, the mechanical treatment of the fuel pellet needs to be improved. The study is part of a global way of improving the treatment of pellet-cladding interaction (PCI) in the 1D finite elements EDF code named CYRANO3. Non-axisymmetrical multidirectional effects have to be accounted for in a context of unidirectional axisymmetrical finite elements. The aim of this work is double. Firstly a model simulating the effect of stress concentration on the cladding, due to the opening of the radial cracks of fuel, had been added in the code. Then, the fragmented state of fuel material has been taken into account in the thermomechanical calculation, through a model which led the strain and stress relaxation in the pellet due to the fragmentation, be simulated. This model has been implemented in the code for two types of fuel behaviour: elastic and viscoplastic. (author)

  13. Analysis of Seismic Soil-Structure Interaction for a Nuclear Power Plant (HTR-10

    Directory of Open Access Journals (Sweden)

    Xiaoxin Wang

    2017-01-01

    Full Text Available The response of nuclear power plants (NPPs to seismic events is affected by soil-structure interactions (SSI. In the present paper, a finite element (FE model with transmitting boundaries is used to analyse the SSI effect on the response of NPP buildings subjected to vertically incident seismic excitation. Analysis parameters that affect the accuracy of the calculations, including the dimension of the domain and artificial boundary types, are investigated through a set of models. A numerical SSI analysis for the 10 MW High Temperature Gas Cooled Test Reactor (HTR-10 under seismic excitation was carried out using the developed model. The floor response spectra (FRS produced by the SSI analysis are compared with a fixed-base model to investigate the SSI effect on the dynamic response of the reactor building. The results show that the FRS at foundation level are reduced and those at higher floor levels are altered significantly when taking SSI into account. The peak frequencies of the FRS are reduced due to the SSI, whereas the acceleration at high floor levels is increased at a certain frequency range. The seismic response of the primary system components, however, is reduced by the analysed SSI for the HTR-10 on the current soil site.

  14. Optimizing Sparse Matrix-Multiple Vectors Multiplication for Nuclear Configuration Interaction Calculations

    Energy Technology Data Exchange (ETDEWEB)

    Aktulga, Hasan Metin [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Buluc, Aydin [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Williams, Samuel [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Yang, Chao [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2014-08-14

    Obtaining highly accurate predictions on the properties of light atomic nuclei using the configuration interaction (CI) approach requires computing a few extremal Eigen pairs of the many-body nuclear Hamiltonian matrix. In the Many-body Fermion Dynamics for nuclei (MFDn) code, a block Eigen solver is used for this purpose. Due to the large size of the sparse matrices involved, a significant fraction of the time spent on the Eigen value computations is associated with the multiplication of a sparse matrix (and the transpose of that matrix) with multiple vectors (SpMM and SpMM-T). Existing implementations of SpMM and SpMM-T significantly underperform expectations. Thus, in this paper, we present and analyze optimized implementations of SpMM and SpMM-T. We base our implementation on the compressed sparse blocks (CSB) matrix format and target systems with multi-core architectures. We develop a performance model that allows us to understand and estimate the performance characteristics of our SpMM kernel implementations, and demonstrate the efficiency of our implementation on a series of real-world matrices extracted from MFDn. In particular, we obtain 3-4 speedup on the requisite operations over good implementations based on the commonly used compressed sparse row (CSR) matrix format. The improvements in the SpMM kernel suggest we may attain roughly a 40% speed up in the overall execution time of the block Eigen solver used in MFDn.

  15. Characterization of elastic interactions in GaAs/Si composites by optically pumped nuclear magnetic resonance

    Energy Technology Data Exchange (ETDEWEB)

    Wood, Ryan M.; Tokarski, John T.; McCarthy, Lauren A.; Bowers, Clifford R., E-mail: bowers@chem.ufl.edu [Department of Chemistry, University of Florida, Gainesville, Florida 32611 (United States); Stanton, Christopher J. [Department of Physics, University of Florida, Gainesville, Florida 32611 (United States)

    2016-08-28

    Elastic interactions in GaAs/Si bilayer composite structures were studied by optically pumped nuclear magnetic resonance (OPNMR). The composites were fabricated by epoxy bonding of a single crystal of GaAs to a single crystal of Si at 373 K followed by selective chemical etching of the GaAs at room temperature to obtain a series of samples with GaAs thickness varying from 37 μm to 635 μm, while the Si support thickness remained fixed at 650 μm. Upon cooling to below 10 K, a biaxial tensile stress developed in the GaAs film due to differential thermal contraction. The strain perpendicular to the plane of the bilayer and localized near the surface of the GaAs was deduced from the quadrupolar splitting of the Gallium-71 OPNMR resonance. Strain relaxation by bowing of the composite was observed to an extent that depended on the relative thickness of the GaAs and Si layers. The variation of the strain with GaAs layer thickness was found to be in good agreement with a general analytical model for the elastic relationships in composite media.

  16. Interaction forces model on a bubble growing for nuclear best estimate computer codes

    International Nuclear Information System (INIS)

    Espinosa-Paredes, Gilberto; Nunez-Carrera, Alejandro; Martinez-Mendez, Elizabeth J.

    2005-01-01

    This paper presents a mathematical model that takes into account the bubble radius variation that take place in a boiling water nuclear reactor during transients with changes in the pressure vessel, changes in the inlet core mass flow rate, density-wave phenomena or flow regime instability. The model with expansion effects was developed considering the interaction force between a dilute dispersion of gas bubbles and a continuous liquid phase. The closure relationships were formulated as an associated problem with the spatial deviation around averaging variables as a function of known variables. In order to solve the closure problem, a geometric model given by an eccentric unit cell was applied as an approach of heterogeneous structure of the two-phase flow. The closure relationship includes additional terms that represent combined effects between translation and pulsation due to displacement and size variation of the bubbles, respectively. This result can be implanted straightforward in best estimate thermo-hydraulics models. An example, the implementation of the closure relationships into TRAC best estimate computer code is presented

  17. Natural interfaces for interacting with a virtual control desk of a nuclear power plant simulator

    International Nuclear Information System (INIS)

    Aghina, Mauricio Alves da Cunha e

    2012-01-01

    Due to very strict standards of safe operation of a nuclear power plant operators must be well trained so they can operate it within the necessary safety procedures. This is done through training simulators, which enable the user operation, as close as possible to the real control desk, and can be inserted accident situations, so they train, how to return the plant to a normal operating condition. Normally is used two types of simulator. Preferred is the full scope simulator, what is a computational dynamics program of the plant used in conjunction with a physical replica of the control desk, but this type of simulator involves a high construction cost. The second type is what uses synoptic windows of various regions of the original control desk, its construction cost is smaller, but it have a little fidelity to the original appearance of the table. Currently, with the use of virtual reality, control desks can be modeled in 3D, making the simulator interface is very similar to the appearance of the real control desk with a low cost construction. This work shows the use of natural interfaces for operator interaction with the virtual control desk, in order that it does not use any mechanical device for displaying and acting with it. For procedures that were used, such as: computer vision to recognize the position of the operator's and observation of their hands to the work of the desk controls and voice recognition. (author)

  18. Interactive simulation of nuclear power systems using a dedicated minicomputer - computer graphics facility

    International Nuclear Information System (INIS)

    Tye, C.; Sezgen, A.O.

    1980-01-01

    The design of control systems and operational procedures for large scale nuclear power plant poses a difficult optimization problem requiring a lot of computational effort. Plant dynamic simulation using digital minicomputers offers the prospect of relatively low cost computing and when combined with graphical input/output provides a powerful tool for studying such problems. The paper discusses the results obtained from a simulation study carried out at the Computer Graphics Unit of the University of Manchester using a typical station control model for an Advanced Gas Cooled reactor. Particular reference is placed on the use of computer graphics for information display, parameter and control system optimization and techniques for using graphical input for defining and/or modifying the control system topology. Experience gained from this study has shown that a relatively modest minicomputer system can be used for simulating large scale dynamic systems and that highly interactive computer graphics can be used to advantage to relieve the designer of many of the tedious aspects of simulation leaving him free to concentrate on the more creative aspects of his work. (author)

  19. An analysis of the role of nuclear power in Korea under the environmental constraints through energy-economy interaction model

    International Nuclear Information System (INIS)

    Lim, Chae Young

    1998-02-01

    An analysis on the role of nuclear energy system for meeting the future global environmental constraint of CO 2 emission regulation was made using an energy-economy interaction model - EFOM-MACRO-KOREA. In case of carbon taxation which is likely to be adopted as policy measure for CO 2 abatement, the role of nuclear energy for sustainable energy system as well as the economic impacts has been assessed. For the analysis, the energy system optimizations under the various scenarios of tax rate and nuclear installation expansion have been achieved using non-linear programing whose objective function is the summation of discounted utilities of whole periods. As a result, the role of nuclear energy system up to the year 2040 is forecasted. In order to stabilize the carbon emission during the whole period to the emission level of 2005 at business-as-usual scenario, the carbon tax of 400 US dollars per ton of carbon is required. For two scenarios with the same tax scheme and different nuclear installation growth, the smaller the nuclear growth, the more GDP loss and CO 2 emission. Required nuclear energy capacity for stabilization would be over 80 additional nuclear power units. However, the maximum proposed sites in Korea is about 40 units. The realistic limitation to nuclear power expansion would be siting due to the public acceptance. The results shows that the adopted modeling approach is suitable for the impacts analysis of the environmental policy such as carbon tax imposition which affects economy as well as the energy sector

  20. Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis

    Directory of Open Access Journals (Sweden)

    Robinson Melvin L

    2005-07-01

    Full Text Available Abstract Background The Cajal body (CB is a nuclear suborganelle involved in the biogenesis of small nuclear ribonucleoproteins (snRNPs, which are vital for pre-mRNA splicing. Newly imported Sm-class snRNPs traffic through CBs, where the snRNA component of the snRNP is modified, and then target to other nuclear domains such as speckles and perichromatin fibrils. It is not known how nascent snRNPs localize to the CB and are released from this structure after modification. The marker protein for CBs, coilin, may play a role in snRNP biogenesis given that it can interact with snRNPs and SMN, the protein mutated in Spinal Muscular Atrophy. Loss of coilin function in mice leads to significant viability and fertility problems and altered CB formation. Results In this report, we identify a minor isoform of the mitochondrial Tim50, Tim50a, as a coilin interacting protein. The Tim50a transcript can be detected in some cancer cell lines and normal brain tissue. The Tim50a protein differs only from Tim50 in that it contains an additional 103 aa N-terminal to the translation start of Tim50. Importantly, a putative nuclear localization signal is found within these 103 residues. In contrast to Tim50, which localizes to the cytoplasm and mitochondria, Tim50a is strictly nuclear and is enriched in speckles with snRNPs. In addition to coilin, Tim50a interacts with snRNPs and SMN. Competition binding experiments demonstrate that coilin competes with Sm proteins of snRNPs and SMN for binding sites on Tim50a. Conclusion Tim50a may play a role in snRNP biogenesis given its cellular localization and protein interaction characteristics. We hypothesize that Tim50a takes part in the release of snRNPs and SMN from the CB.

  1. Congressional-executive interaction and the nuclear waste repository site selection process

    International Nuclear Information System (INIS)

    Thurber, J.A.; Evanson, T.C.

    1993-01-01

    The Nuclear Waste Policy Act of 1982 (NWPA) (P.L. 97-425) and the Nuclear Waste Policy Amendments Act of 1987 (NWPAA) (Title V of P.L. 100-203) provide the framework for the DOE Office of Civilian Radioactive Waste Management (OCRWM) to find a permanent means for disposing of high-level nuclear waste in the US. The focus of this study is the congressional decision-making process associated with passage of the Nuclear Waste Policy Amendments Act of 1987. The passage of NWPAA was a direct result of the failure of the policy adopted in the Nuclear Waste Policy Act of 1982. This study analyzes the nature of congressional nuclear waste policy-making through the lens of subsystems theory. The data analysis is primarily based on confidential interviews with over fifty key actors in the nuclear waste policy subsystem as well as an analysis of primary source documents

  2. Summary report of consultants' meeting on nuclear data of charged-particle interactions for medical therapy applications

    International Nuclear Information System (INIS)

    Capote Noy, R.; Vatnitskiy, S.

    2007-01-01

    A summary is given of a Consultants' Meeting assembled to assess the viability of a new IAEA Co-ordinated Research Project (CRP) on Charged-Particle Interaction Data for Radiotherapy. The need for a programme to compile and evaluate charged-particle nuclear data for therapeutic applications was strongly agreed. Both the technical discussions and the expected outcomes of such a project are described, along with detailed recommendations for implementation. The meeting was jointly organized by NAPC/Nuclear Data Section and NAHU/Dosimetry and Medical Radiation Physics Section. (author)

  3. Nuclear

    International Nuclear Information System (INIS)

    2014-01-01

    This document proposes a presentation and discussion of the main notions, issues, principles, or characteristics related to nuclear energy: radioactivity (presence in the environment, explanation, measurement, periods and activities, low doses, applications), fuel cycle (front end, mining and ore concentration, refining and conversion, fuel fabrication, in the reactor, back end with reprocessing and recycling, transport), the future of the thorium-based fuel cycle (motivations, benefits and drawbacks), nuclear reactors (principles of fission reactors, reactor types, PWR reactors, BWR, heavy-water reactor, high temperature reactor of HTR, future reactors), nuclear wastes (classification, packaging and storage, legal aspects, vitrification, choice of a deep storage option, quantities and costs, foreign practices), radioactive releases of nuclear installations (main released radio-elements, radioactive releases by nuclear reactors and by La Hague plant, gaseous and liquid effluents, impact of releases, regulation), the OSPAR Convention, management and safety of nuclear activities (from control to quality insurance, to quality management and to sustainable development), national safety bodies (mission, means, organisation and activities of ASN, IRSN, HCTISN), international bodies, nuclear and medicine (applications of radioactivity, medical imagery, radiotherapy, doses in nuclear medicine, implementation, the accident in Epinal), nuclear and R and D (past R and D programmes and expenses, main actors in France and present funding, main R and D axis, international cooperation)

  4. Low-temperature nuclear magnetic resonance investigation of systems frustrated by competing exchange interactions

    Science.gov (United States)

    Roy, Beas

    This doctoral thesis emphasizes on the study of frustrated systems which form a very interesting class of compounds in physics. The technique used for the investigation of the magnetic properties of the frustrated materials is Nuclear Magnetic Resonance (NMR). NMR is a very novel tool for the microscopic study of the spin systems. NMR enables us to investigate the local magnetic properties of any system exclusively. The NMR experiments on the different systems yield us knowledge of the static as well as the dynamic behavior of the electronic spins. Frustrated systems bear great possibilities of revelation of new physics through the new ground states they exhibit. The vandates AA'VO(PO4)2 [AA' ≡ Zn2 and BaCd] are great prototypes of the J1-J2 model which consists of magnetic ions sitting on the corners of a square lattice. Frustration is caused by the competing nearest-neighbor (NN) and next-nearest neighbor (NNN) exchange interactions. The NMR investigation concludes a columnar antiferromagnetic (AFM) state for both the compounds from the sharp peak of the nuclear spin-lattice relaxation rate (1/T1) and a sudden broadening of the 31P-NMR spectrum. The important conclusion from our study is the establishment of the first H-P-T phase diagram of BaCdVO(PO4)2. Application of high pressure reduces the saturation field (HS) in BaCdVO(PO4)2 and decreases the ratio J2/J1, pushing the system more towards a questionable boundary (a disordered ground state) between the columnar AFM and a ferromagnetic ground state. A pressure up to 2.4 GPa will completely suppress HS. The Fe ions in the `122' iron-arsenide superconductors also sit on a square lattice thus closely resembling the J1-J2 model. The 75As-NMR and Nuclear Quadrupole Resonance (NQR) experiments are conducted in the compound CaFe2As2 prepared by two different heat treatment methods (`as-grown' and `annealed'). Interestingly the two samples show two different ground states. While the ground state of the `as

  5. Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B antigen

    International Nuclear Information System (INIS)

    Habets, W.J.; Sillekens, P.T.G.; Hoet, M.H.; Schalken, J.A.; Roebroek, A.J.M.; Leunissen, J.A.M.; Van de Ven, W.J.M.; Van Venrooij, W.J.

    1987-01-01

    A U2 small nuclear RNA-associated protein, designated B'', was recently identified as the target antigen for autoimmune sera from certain patients with systemic lupus erythematosus and other rheumatic diseases. Such antibodies enabled them to isolate cDNA clone λHB''-1 from a phage λgt11 expression library. This clone appeared to code for the B'' protein as established by in vitro translation of hybrid-selected mRNA. The identity of clone λHB''-1 was further confirmed by partial peptide mapping and analysis of the reactivity of the recombinant antigen with monospecific and monoclonal antibodies. Analysis of the nucleotide sequence of the 1015-base-pair cDNA insert of clone λHB''-1 revealed a large open reading frame of 800 nucleotides containing the coding sequence for a polypeptide of 25,457 daltons. In vitro transcription of the λHB''-1 cDNA insert and subsequent translation resulted in a protein product with the molecular size of the B'' protein. These data demonstrate that clone λHB''-1 contains the complete coding sequence of this antigen. The deduced polypeptide sequence contains three very hydrophilic regions that might constitute RNA binding sites and/or antigenic determinants. These findings might have implications both for the understanding of the pathogenesis of rheumatic diseases as well as for the elucidation of the biological function of autoimmune antigens

  6. The normal chain length distribution of the O antigen is required for the interaction of Shigella flexneri 2a with polarized Caco-2 cells

    Directory of Open Access Journals (Sweden)

    Anilei Hoare

    2012-01-01

    Full Text Available Shigella flexneri causes bacillary dysentery in humans. Essential to the establishment of the disease is the invasion of the colonic epithelial cells. Here we investigated the role of the lipopolysaccharide (LPS O antigen in the ability of S. flexneri to adhere to and invade polarized Caco-2 cells. The S. flexneri 2a O antigen has two preferred chain lengths: a short O antigen (S-OAg regulated by the WzzB protein and a very long O antigen (VL-OAg regulated by Wzz pHS2. Mutants with defined deletions of the genes required for O-antigen assembly and polymerization were constructed and assayed for their abilities to adhere to and enter cultured epithelial cells. The results show that both VL- and S-OAg are required for invasion through the basolateral cell membrane. In contrast, the absence of O antigen does not impair adhesion. Purified LPS does not act as a competitor for the invasion of Caco-2 cells by the wild-type strain, suggesting that LPS is not directly involved in the internalization process by epithelial cells.

  7. Nuclear fuel element

    International Nuclear Information System (INIS)

    1974-01-01

    A nuclear fuel element for use in the core of a nuclear reactor is disclosed. A heat conducting fission product retaining metal liner of a refractory metal is incorporated in the fuel element between the cladding and the nuclear fuel to inhibit mechanical interaction between the nuclear fuel and the cladding, to isolate fission products and nuclear fuel impurities from contacting the cladding, and to improve the axial thermal peaking gradient along the length of the fuel rod. The metal liner can be in the form of a tube or hollow cylindrical column, a foil of single or multiple layers in the shape of a hollow cylindrical column, or a coating on the internal surface of the cladding. Preferred refractory metal materials are molybdenum, tungsten, rhenium, niobium and alloys of the foregoing metals

  8. Nuclear fuel element

    International Nuclear Information System (INIS)

    Thompson, J.R.; Rowland, T.C.

    1976-01-01

    A nuclear fuel element for use in the core of a nuclear reactor is disclosed. A heat conducting, fission product retaining metal liner of a refractory metal is incorporated in the fuel element between the cladding and the nuclear fuel to inhibit mechanical interaction between the nuclear fuel and the cladding, to isolate fission products and nuclear fuel impurities from contacting the cladding and to improve the axial thermal peaking gradient along the length of the fuel rod. The metal liner can be in the form of a tube or hollow cylindrical column, a foil of single or multiple layers in the shape of a hollow cylindrical column, or a coating on the internal surface of the cladding. Preferred refractory metal materials are molybdenum, tungsten, rhenium, niobium and alloys of the foregoing metals

  9. Interactive information system on the nuclear physics properties of nuclides and radioactive decay chains

    International Nuclear Information System (INIS)

    Plyaskin, V.I.; Kosilov, R.A.; Manturov, G.N.

    2001-01-01

    A brief review is given of a computerized information system on the nuclear physics properties of nuclides and radioactive decay chains. The main difference between the system presented here and those already in existence is that these evaluated databases of nuclear physics constants are linked to a set of programs, thus enabling analysis of a wide range of problems regarding various nuclear physics applications. (author)

  10. Formal specification and verification of interactive systems with plasticity: Applications to nuclear-plant supervision

    International Nuclear Information System (INIS)

    Oliveira, Raquel Araujo de

    2015-01-01

    specification. Usability properties verify whether the system follows ergonomic properties to ensure a good usability. Validity properties verify whether the system follows the requirements that specify its expected behavior.-The comparison of different versions of UIs. Using equivalence checking, our approach verifies to which extent UIs present the same interaction capabilities and appearance. We can show whether two UI models are equivalent or not. When they are not equivalent, the UI divergences are listed, thus providing the possibility of leaving them out of the analysis. Furthermore, the approach shows that one UI can contain at least all interaction capabilities of another. We also present in this thesis three industrial case studies in the nuclear power plant domain which the approach was applied to, providing additional examples of successful use of formal methods in industrial systems. (author)

  11. Seismic fragility analysis of a nuclear building based on probabilistic seismic hazard assessment and soil-structure interaction analysis

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, R.; Ni, S.; Chen, R.; Han, X.M. [CANDU Energy Inc, Mississauga, Ontario (Canada); Mullin, D. [New Brunswick Power, Point Lepreau, New Brunswick (Canada)

    2016-09-15

    Seismic fragility analyses are conducted as part of seismic probabilistic safety assessment (SPSA) for nuclear facilities. Probabilistic seismic hazard assessment (PSHA) has been undertaken for a nuclear power plant in eastern Canada. Uniform Hazard Spectra (UHS), obtained from the PSHA, is characterized by high frequency content which differs from the original plant design basis earthquake spectral shape. Seismic fragility calculations for the service building of a CANDU 6 nuclear power plant suggests that the high frequency effects of the UHS can be mitigated through site response analysis with site specific geological conditions and state-of-the-art soil-structure interaction analysis. In this paper, it is shown that by performing a detailed seismic analysis using the latest technology, the conservatism embedded in the original seismic design can be quantified and the seismic capacity of the building in terms of High Confidence of Low Probability of Failure (HCLPF) can be improved. (author)

  12. The structure of 112In nuclear isomers and their interaction with extranuclear fields

    International Nuclear Information System (INIS)

    Ionescu-Bujor, M.

    1979-01-01

    Research on the structure of short life-time isomeric states of 112 In and their interaction with extranuclear fields is presented. Isomeric states have been populated in reactions 112 Cd(p,n), 109 Ag(α,n) and 112 Cd(d,2n) using the pulsated beam method. The results of the studies performed can be summarized as it follows: I. Nuclear structure. In the case of 112 In, there are two isomeric states having Jsup(π)=8 - (Tsub(1/2)=2.81.μs) and Jsup(π)=6 + (Tsub(1/2)=0.69.μs) and excitation energies of 606,0 KeV. The desintegration procedure schematically represented of the new isomeric states is: 8 - (262.7 KeV - M2) 6 + (187.8 KeV - E2)4 + . The magnetic momenta of the isomeric states are: π(8 - )-3.03+-0.03 m.n. μ(6 + )-4.05+-0.04 m.n. The quadripolar electric momentum of the 8 - isomeric state is: [Q(8 - )] = 0.093 +- 0.006 b. The 8 - isomeric state stands for the minimum energy level of the multiplet generated by the [π(lgsub(9/2))ν(1hsub(11/2))] configuration. The 6 + isomeric state was described by a mixture of configurations resulting from coupling the lgsub(9/2) proton state with the 2dsub(5/2), 2dsub(3/2) and lgsub(7/2) neutron states. II. Population sections. In studying the relations of isomeric sections into double even isotopes sup(110-116)In, excited in (p,n) reactions, a very high population of the 8 - isomeric states is pointed out, on condition that the positive parity isomeric states were satisfactorily described in the statistical model. The anomaly observed in the population of states 8 - can be explained by the influence of the selection rule after γ upon transitions γ, which confirm the existence of the multiplet of levels generated by the [π(lgsub(9/2))ν(1hsub(11/2))] pure configuration in these nuclei. III. Examination of effects induced by irradiation defects in the InAg system. The short life-time isomeric states of 112 In, excited in reaction 109 (α,n), were used in the study of hyperfine interactions by means of the method of

  13. Reporter cell lines for the characterization of the interactions between nuclear receptors and endocrine disruptors

    Directory of Open Access Journals (Sweden)

    marina egrimaldi

    2015-05-01

    Full Text Available Endocrine-disrupting chemicals (EDCs are exogenous substances interfering with hormone biosynthesis, metabolism, or action, and consequently causing disturbances in the endocrine system. Various pathways are activated by EDCs, including interactions with nuclear receptors (NRs which are primary targets of numerous environmental contaminants.The main NRs targeted by environmental contaminants are the estrogen (ER α, β and the androgen (AR receptors. ERs and AR have pleiotropic regulatory roles in a diverse range of tissues, notably in the mammary gland, the uterus and the prostate. Thus, dysfunctional ERs and AR signaling due to inappropriate exposure to environmental pollutants may lead to hormonal cancers and infertility. The pregnane X receptor (PXR is also recognized by many environmental molecules. PXR has a protective role of the body through its ability to regulate proteins involved in the metabolism, the conjugation and the transport of many exogenous and endogenous compounds. However, the permanent activation of this receptor by xenobiotics may lead to premature drug metabolism, the formation and accumulation of toxic metabolites and defects in hormones homeostasis. The activity of other NRs can also be affected by environmental molecules. Compounds capable of inhibiting or activating the estrogen related (ERRγ, the thyroid hormone (TRα, β, the retinoid X receptors (RXRα, β, γ and peroxisome proliferator-activated (PPAR α, γ receptors have been identified and are highly suspected to promote developmental, reproductive, neurological, or metabolic diseases in humans and wildlife.In this review we provide an overview of reporter cell lines established to characterize the human NR activities of a large panel of EDCs including natural as well as industrial compounds such as pesticides, plasticizers, surfactants, flame retardants and cosmetics.

  14. Dynamic Nuclear Polarization enhanced NMR at 187 GHz/284 MHz using an Extended Interaction Klystron amplifier.

    Science.gov (United States)

    Kemp, Thomas F; Dannatt, Hugh R W; Barrow, Nathan S; Watts, Anthony; Brown, Steven P; Newton, Mark E; Dupree, Ray

    2016-04-01

    A Dynamic Nuclear Polarisation (DNP) enhanced solid-state Magic Angle Spinning (MAS) NMR spectrometer which uses a 187 GHz (corresponding to (1)H NMR frequency of 284 MHz) Extended Interaction Klystron (EIK) amplifier as the microwave source is briefly described. Its performance is demonstrated for a biomolecule (bacteriorhodopsin), a pharmaceutical, and surface functionalised silica. The EIK is very compact and easily incorporated into an existing spectrometer. The bandwidth of the amplifier is sufficient that it obviates the need for a sweepable magnetic field, once set, for all commonly used radicals. The variable power (CW or pulsed) output from the EIK is transmitted to the DNP-NMR probe using a quasi-optic system with a high power isolator and a corrugated waveguide which feeds the microwaves into the DNP-NMR probe. Curved mirrors inside the probe project the microwaves down the axis of the MAS rotor, giving a very efficient system such that maximum DNP enhancement is achieved with less than 3 W output from the microwave source. The DNP-NMR probe operates with a sample temperature down to 90K whilst spinning at 8 kHz. Significant enhancements, in excess of 100 for bacteriorhodopsin in purple membrane (bR in PM), are shown along with spectra which are enhanced by ≈25 with respect to room temperature, for both the pharmaceutical furosemide and surface functionalised silica. These enhancements allow hitherto prohibitively time consuming experiments to be undertaken. The power at which the DNP enhancement in bR in PM saturates does not change significantly between 90K and 170 K even though the enhancement drops by a factor of ≈11. As the DNP build up time decreases by a factor 3 over this temperature range, the reduction in T1n is presumably a significant contribution to the drop in enhancement. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  15. Investigation of energy spectrum and nuclear interactions of primary cosmic radiation; Badanie widma energetycznego i oddzialywan jadrowych pierwotnego promieniowania kosmicznego

    Energy Technology Data Exchange (ETDEWEB)

    Wilczynski, H. [Dept. of High Energy Physics, The H. Niewodniczanski Inst. of Nuclear Physics, Cracow (Poland)

    1996-12-31

    In the paper the JACEE experiment data analysis: energy spectra in the energy range 10{sup 12} - 10{sup 15} eV of different nuclides in cosmic radiation and some aspects of nuclear interactions at energy above 10{sup 12} eV/nucleon is presented. The data were compared with results of theory of cosmic radiation acceleration by striking waves arises from supernova stars explosions. In the interactions of cosmic radiation nuclei the short-lived particles production has been observed what agrees with long-distance component of cascades initiated by cosmic radiation interactions. In one case an interaction with asymmetric photons emission were observed 72 refs, 33 figs, 4 tabs

  16. Further evidences for enhanced nuclear cross-sections observed in 44 GeV carbon ion interactions with copper

    International Nuclear Information System (INIS)

    Brandt, R.; Abdullaev, I.G.; Adloff, J.C.

    1995-01-01

    The work of enhanced nuclear cross-sections of secondary fragments produced in the interaction of 44 GeV 12 C with copper has been deepened and extended. The earlier experiment on the emission of secondary fragments into large angles producing enhanced amounts of 24 Na in copper (Phys. Rev. C, 45, 1194(1992)) was confirmed and refined both experimentally and theoretically. In this context, one looked for another signature of such enhanced production, namely for enhanced neutron production. In order to search for this, a 20 cm thick massive copper target was irradiated with 18 and 44 GeV 12 C-ions. Secondary fragments already described could interact again with copper. Outside the metallic target, secondary neutrons got moderated and low energy nuclear reactions were studied in La and U radiochemically via (n,γ)-reactions and also with various solid state nuclear track detectors. One observed an indication, however not yet significant, of enhanced production rates for low energy nuclear reactions only with 44 GeV 12 C, when compared to 18 GeV 12 C-ions. Besides some proton irradiations at SATURNE, Saclay (France) at 2.6 GeV and at PSI, Villigen (Switzerland) at 0.6 GeV all other irradiations were carried out at the Synchrophasotron, LHE, JINR, Dubna (Russia). 46 refs., 14 figs., 8 tabs

  17. Study of nuclear medium effects on the effective interaction based on the one-boson exchange model

    International Nuclear Information System (INIS)

    Nakayama, K.

    1985-02-01

    In this work, starting from a realistic nucleon-nucleon interaction based on the one-boson exchange model for the nuclear force, we attempted a microscopic derivation of the effective interaction which may be appropriate for nuclear structure as well as for nucleon-nucleus scattering problems. Short-range correlations and medium polarization as well as relativistic effects on both particle-hole and Δ-hole interactions have been investigated. For the nucleon-nucleon case short-range correlations are basically restricted to S-states and affect mainly the central components of the effective interaction. In contrast, the Δ-nucleon interaction is essentially unaffected by short-range correlations due to the Pauli principle restrictions and the momentum mismatch between the central components of the correlation operator and the tensor component of the bare transition potential. Based on these analyses it is shown that short-range correlation effects can be summarized in a very simple correlation operator. (orig./HSI)

  18. A protein interaction atlas for the nuclear receptors: properties and quality of a hub-based dimerisation network

    Directory of Open Access Journals (Sweden)

    De Graaf David

    2007-07-01

    Full Text Available Abstract Background The nuclear receptors are a large family of eukaryotic transcription factors that constitute major pharmacological targets. They exert their combinatorial control through homotypic heterodimerisation. Elucidation of this dimerisation network is vital in order to understand the complex dynamics and potential cross-talk involved. Results Phylogeny, protein-protein interactions, protein-DNA interactions and gene expression data have been integrated to provide a comprehensive and up-to-date description of the topology and properties of the nuclear receptor interaction network in humans. We discriminate between DNA-binding and non-DNA-binding dimers, and provide a comprehensive interaction map, that identifies potential cross-talk between the various pathways of nuclear receptors. Conclusion We infer that the topology of this network is hub-based, and much more connected than previously thought. The hub-based topology of the network and the wide tissue expression pattern of NRs create a highly competitive environment for the common heterodimerising partners. Furthermore, a significant number of negative feedback loops is present, with the hub protein SHP [NR0B2] playing a major role. We also compare the evolution, topology and properties of the nuclear receptor network with the hub-based dimerisation network of the bHLH transcription factors in order to identify both unique themes and ubiquitous properties in gene regulation. In terms of methodology, we conclude that such a comprehensive picture can only be assembled by semi-automated text-mining, manual curation and integration of data from various sources.

  19. Nuclear theory group. Progress report and renewal proposal

    International Nuclear Information System (INIS)

    1979-01-01

    The work discussed covers a broad range of topics in theoretical nuclear and intermediate-energy physics and nuclear astrophysics. Primary emphasis is placed on understanding the underlying nucleon-nucleon and meson-nucleon interactions. The research is categorized as follows: fundamental interactions; intermediate-energy physics; effective interactions, nuclear models and many-body theory; structure of finite nuclei; nuclear astrophysics; heavy-ion physics; and numerical analysis. Page-length summaries of the work are given; completed work has been or will be published. Staff vitas, recent publications, and a proposed budget complete the report

  20. Repulsive four-body interactions of α particles and quasistable nuclear α -particle condensates in heavy self-conjugate nuclei

    Science.gov (United States)

    Bai, Dong; Ren, Zhongzhou

    2018-05-01

    We study the effects of repulsive four-body interactions of α particles on nuclear α -particle condensates in heavy self-conjugate nuclei using a semianalytic approach, and find that the repulsive four-body interactions could decrease the critical number of α particles, beyond which quasistable α -particle condensate states can no longer exist, even if these four-body interactions make only tiny contributions to the total energy of the Hoyle-like state of 16O. Explicitly, we study eight benchmark parameter sets, and find that the critical number Ncr decreases by |Δ Ncr|˜1 -4 from Ncr˜11 with vanishing four-body interactions. We also discuss the effects of four-body interactions on energies and radii of α -particle condensates. Our study can be useful for future experiments to study α -particle condensates in heavy self-conjugate nuclei. Also, the experimental determination of Ncr will eventually help establish a better understanding on the α -particle interactions, especially the four-body interactions.

  1. Use of Second Life for interactive instruction and distance learning in nuclear physics and technology

    Science.gov (United States)

    Amme, Robert C.

    2009-05-01

    The developing nuclear power renaissance, coupled with related environmental consequences, is forcing a re-examination of the manner in which nuclear science and technology is (or is not) being taught in the United States. The 20-year hiatus of the nuclear power industry has been a decided factor in the relatively stagnant growth of nuclear physics and nuclear technology instruction, from middle school to graduate education. Furthermore, the general public remains fairly ignorant of the various features of nuclear power, at best having been briefly exposed to the subject only in a middle-school course in Physical Science. Essential to this renaissance is the capacity to deal with the regulatory environment and safety standards that must be addressed prior to new plant certification. Regrettably, too few individuals who are trained in environmental science are adequately prepared in the basic concepts of nuclear physics to deal with such issues as radioactive waste storage and transportation, biological effects of ionizing radiation, geological repositories, nuclear fuel reprocessing, etc. which are of great concern to the Nuclear Regulatory Commission. We are developing a master's degree, to be taught online, in the area of environmental impact assessment as it relates to these and other issues. To accommodate the need for laboratory exercises, we have adopted the virtual world developed by Linden Laboratory entitled Second Life; it is here that the student, as an avatar, will gain knowledge of the nature of ionizing radiation, radioactive half-lives, gamma and beta ray spectroscopy, neutron activation, and radiation shielding, using virtual apparatus and virtual radiation sources. Additionally, a virtual Generation III+ power reactor has been constructed on an adjoining Second Life island (entitled Science School II) which provides the visitor with a realistic impression of its inner workings. This presentation will provide the details of this construct and how it

  2. Nuclear import of cutaneous beta genus HPV8 E7 oncoprotein is mediated by hydrophobic interactions between its zinc-binding domain and FG nucleoporins

    Energy Technology Data Exchange (ETDEWEB)

    Onder, Zeynep; Moroianu, Junona, E-mail: moroianu@bc.edu

    2014-01-20

    We have previously discovered and characterized the nuclear import pathways for the E7 oncoproteins of mucosal alpha genus HPVs, type 16 and 11. Here we investigated the nuclear import of cutaneous beta genus HPV8 E7 protein using confocal microscopy after transfections of HeLa cells with EGFP-8E7 and mutant plasmids and nuclear import assays in digitonin-permeabilized HeLa cells. We determined that HPV8 E7 contains a nuclear localization signal (NLS) within its zinc-binding domain that mediates its nuclear import. Furthermore, we discovered that a mostly hydrophobic patch {sub 65}LRLFV{sub 69} within the zinc-binding domain is essential for the nuclear import and localization of HPV8 E7 via hydrophobic interactions with the FG nucleoporins Nup62 and Nup153. Substitution of the hydrophobic residues within the {sub 65}LRLFV{sub 69} patch to alanines, and not R66A mutation, disrupt the interactions between the 8E7 zinc-binding domain and Nup62 and Nup153 and consequently inhibit nuclear import of HPV8 E7. - Highlights: • HPV8 E7 has a cNLS within its zinc-binding domain that mediates its nuclear import. • Discovery of a hydrophobic patch that is critical for the nuclear import of HPV8 E7. • HPV8 E7 nuclear import is mediated by hydrophobic interactions with FG-Nups, Nup62 and Nup153.

  3. Interactive Virtual Reactor and Control Room for Education and Training at Universities and Nuclear Power Plants

    International Nuclear Information System (INIS)

    Satoh, Yoshinori; Li, Ye; Zhu, Xuefeng; Rizwan, Uddin

    2014-01-01

    Efficient and effective education and training of nuclear engineering students and nuclear workers are critical for the safe operation and maintenance of nuclear power plants. With an eye toward this need, we have focused on the development of 3D models of virtual labs for education, training as well as to conduct virtual experiments. These virtual labs, that are expected to supplement currently available resources, and have the potential to reduce the cost of education and training, are most easily developed on game-engine platforms. We report some recent extensions to the virtual model of the University of Illinois TRIGA reactor

  4. Interactive Virtual Reactor and Control Room for Education and Training at Universities and Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Satoh, Yoshinori; Li, Ye; Zhu, Xuefeng; Rizwan, Uddin [University of Illinois, Urbana (United States)

    2014-08-15

    Efficient and effective education and training of nuclear engineering students and nuclear workers are critical for the safe operation and maintenance of nuclear power plants. With an eye toward this need, we have focused on the development of 3D models of virtual labs for education, training as well as to conduct virtual experiments. These virtual labs, that are expected to supplement currently available resources, and have the potential to reduce the cost of education and training, are most easily developed on game-engine platforms. We report some recent extensions to the virtual model of the University of Illinois TRIGA reactor.

  5. The study on the non-linear soil structure interaction for nuclear power plants

    International Nuclear Information System (INIS)

    Tetsuya Hagiwara; Yoshio Kitada

    2005-01-01

    1. Introduction: JNES is planning a new project to study non-linear soil-structure interaction (SSI) effect under large earthquake ground motions equivalent to and/or over a design earthquake ground motion of S2(The extreme design earthquake). Concerning the SSI test, it is pointed out that handling of the scale effect of the specimen together with the surrounding soil on the earthquake response evaluation of the actual structure is essential issue for the scaled model test. Thus, for the test, the largest specimen possible and the biggest input motion possible are necessary. Taking into account the above issues, new test methodology, which utilizes artificial earthquake ground motion, is considered desirable if it can be performed at a realistic cost. Under this motivation, we have studied the test methodology which applying blasting power as for a big earthquake ground motion. The information from a coal mine company in the U.S.A. indicates that the works performed in the surface coal mine to blast a rock covering a coal layer generates a big artificial ground motion, which is similar to earthquake ground motion. Application of this artificial earthquake ground motion for the SSI test is considered very promising because the blasting work is carried out periodically for mining coal so that we can apply artificial motions generated by the work if we construct a building model at a closed point to the blasting work area. The major purposes of the test will be to understand (a) basic earthquake response characteristics of a Nuclear Power Plant (NPP) reactor building when a large earthquake strikes the NPP site and (b) nonlinear characteristics of SSI phenomenon during a big earthquake. In the paper, we introduce the test method and basic characteristics of measured artificial ground motions generated by the blasting works on an actual site. 2. Conclusion: It was confirmed that the artificial ground motions generated by blasting works have enough acceleration level

  6. Interactions of Histone Acetyltransferase p300 with the Nuclear Proteins Histone and HMGB1, As Revealed by Single Molecule Atomic Force Spectroscopy.

    Science.gov (United States)

    Banerjee, S; Rakshit, T; Sett, S; Mukhopadhyay, R

    2015-10-22

    One of the important properties of the transcriptional coactivator p300 is histone acetyltransferase (HAT) activity that enables p300 to influence chromatin action via histone modulation. p300 can exert its HAT action upon the other nuclear proteins too--one notable example being the transcription-factor-like protein HMGB1, which functions also as a cytokine, and whose accumulation in the cytoplasm, as a response to tissue damage, is triggered by its acetylation. Hitherto, no information on the structure and stability of the complexes between full-length p300 (p300FL) (300 kDa) and the histone/HMGB1 proteins are available, probably due to the presence of unstructured regions within p300FL that makes it difficult to be crystallized. Herein, we have adopted the high-resolution atomic force microscopy (AFM) approach, which allows molecularly resolved three-dimensional contour mapping of a protein molecule of any size and structure. From the off-rate and activation barrier values, obtained using single molecule dynamic force spectroscopy, the biochemical proposition of preferential binding of p300FL to histone H3, compared to the octameric histone, can be validated. Importantly, from the energy landscape of the dissociation events, a model for the p300-histone and the p300-HMGB1 dynamic complexes that HAT forms, can be proposed. The lower unbinding forces of the complexes observed in acetylating conditions, compared to those observed in non-acetylating conditions, indicate that upon acetylation, p300 tends to weakly associate, probably as an outcome of charge alterations on the histone/HMGB1 surface and/or acetylation-induced conformational changes. To our knowledge, for the first time, a single molecule level treatment of the interactions of HAT, where the full-length protein is considered, is being reported.

  7. Chiral effective field theory for nuclear matter including long- and short-range multi-nucleon interactions

    Directory of Open Access Journals (Sweden)

    Oller J.A.

    2010-04-01

    Full Text Available We review on a novel chiral power counting scheme for in-medium chiral perturbation theory with nucleons and pions as degrees of freedom. It allows for a systematic expansion taking into account local as well as pion-mediated inter-nucleon interactions. Based on this power counting, one can identify classes of nonperturbative diagrams that require a resummation. As a method for performing those resummations we review on the techniques of Unitary Chiral Pertubation Theory for nucleon-nucleon interactions. We then apply both power counting and non-perturbative methods to the example of calculating the pion self-energy in asymmetric nuclear matter up-to-and-including next-to-leading order. It is shown that the leading corrections involving in-medium nucleon-nucleon interactions cancel between each other at given chiral orders.

  8. Mitochondrial-nuclear genome interactions in nonalcoholic fatty liver disease in mice

    OpenAIRE

    Betancourt, Angela M.; King, Adrienne L.; Fetterman, Jessica L.; Millender-Swain, Telisha; Finley, Rachel D.; Oliva, Claudia R.; Crowe, David Ralph; Ballinger, Scott W.; Bailey, Shannon M.

    2014-01-01

    Nonalcoholic fatty liver disease (NAFLD) involves significant changes in liver metabolism characterized by oxidative stress, lipid accumulation, and fibrogenesis. Mitochondrial dysfunction and bioenergetic defects also contribute to NAFLD. Herein, we examined whether differences in mtDNA influence NAFLD. To determine the role of mitochondrial and nuclear genomes in NAFLD, Mitochondrial-Nuclear eXchange (MNX) mice were fed an atherogenic diet. MNX mice have mtDNA from C57BL/6...

  9. Soil–structure interaction analyses to locate nuclear power plant free-field seismic instrumentation

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, James J., E-mail: jasjjoh@aol.com [James J. Johnson and Associates, Alamo, CA (United States); Ake, Jon P. [US Nuclear Regulatory Commission, Washington, DC (United States); Maslenikov, Oleg R. [James J. Johnson and Associates, Alamo, CA (United States); Kenneally, Roger M. [Consultant, Seminole, FL (United States)

    2015-12-15

    Highlights: • Determine the location of seismic instrumentation so that recorded motion will be free-field motion. • Certified Designs of nuclear island for AP1000 and EPR; ABWR Reactor Building were analyzed. • Three site conditions and multiple recorded time histories were considered. • Instrumentation located 1-diameter from the edge of structure/foundation is adequate. • Acceptance criteria were probability of non-exceedance of response spectra values. - Abstract: The recorded earthquake ground motion at the nuclear power plant site is needed for several purposes. US Nuclear Regulatory Commission (NRC) Regulatory Guide 1.12, Nuclear Power Plant Instrumentation for Earthquakes, NRC (1997a), describes acceptable instrumentation to meet the requirements in NRC's regulations pertaining to earthquake engineering criteria for nuclear power plants. The ground motion data recorded by the free-field seismic instrumentation are used to compare the actual earthquake motion at the site with the design input motion. The result of the comparison determines if the Operating Basis Earthquake ground motion (OBE) has been exceeded and plant shutdown is required per the guidance in NRC Regulatory Guide 1.166, Pre-Earthquake Planning and Immediate Nuclear Power Plant Operator Postearthquake Actions, NRC (1979b). The free-field is defined as a location on the ground surface or in the site soil column that is sufficiently distant from the site structures to be essentially unaffected by the vibration of the site structures.

  10. Interaction of science and diplomacy: Latin American, the United States and nuclear energy, 1945-1955

    International Nuclear Information System (INIS)

    Cabral, R.

    1986-01-01

    Nuclear programs in Argentina and Brazil can be traced to August 1945 when their scientific communities articulated responses to the atomic bombings of Japan. They culminated in attempts to develop independent nuclear programs, sharply opposed by the United States, during the nationalist governments of Juan Peron and Getulio Vargas. This dissertation, based on primary sources from the three nations, analyzes these programs and the American responses. Latin America entered the nuclear age attempting to control natural resources, to improve scientific establishments, and to appraise Latin American-United States relations. Despite some clear warnings about nuclear dangers, the new form of energy was seen as the solution to industrial problems, poverty, and outside political interference. International opposition, which may have included nuclear threats from the United States, blocked Argentina's first attempt in 1947. After 1948, Peron wanted a nuclear program for cheap energy and prestige. The qualifications of the Brazilian scientists gave more substance to their program. The program originated in August, 1945, but assumed national proportion with the government of Vargas in 1951. Lack of American cooperation forced Vargas to establish a secret program with Germany. American troops intervened taking over the German equipment already completed. The final collapse came about with Vargas' suicide in August, 1954

  11. Nuclear Lipid Microdomain as Place of Interaction between Sphingomyelin and DNA during Liver Regeneration

    Directory of Open Access Journals (Sweden)

    Samuela Cataldi

    2013-03-01

    Full Text Available Nuclear sphingomyelin is a key molecule for cell proliferation. This molecule is organized with cholesterol and proteins to form specific lipid microdomains bound to the inner nuclear membrane where RNA is synthesized. Here, we have reported the ability of the sphingomyelin present in the nuclear microdomain to bind DNA and regulate its synthesis, and to highlight its role in cell proliferation induced by partial hepatectomy. During G1/S transition of the cell cycle, sphingomyelin and DNA content is very high and it is strongly reduced after exogenous sphingomyelinase treatment. During the S-phase of the cell cycle, the stimulation of sphingomyelinase and inhibition of sphingomyelin–synthase are accompanied by the DNA synthesis start. To assess the specificity of the results, experiments were repeated with trifluoperazine, a drug known to affect the synthesis of lipids and DNA and to stimulate sphingomyelinase activity. The activity of sphingomyelinase is stimulated in the first hour after hepatectomy and sphingomyelin–DNA synthesis is strongly attenuated. It may be hypothesized that the nuclear microdomain represents a specific area of the inner nuclear membrane that acts as an active site of chromatin anchorage thanks to the stabilizing action of sphingomyelin. Thus, sphingomyelin metabolism in nuclear lipid microdomains is suggested to regulate cell proliferation.

  12. rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development.

    Science.gov (United States)

    Gates, Julie; Lam, Geanette; Ortiz, José A; Losson, Régine; Thummel, Carl S

    2004-01-01

    Pulses of the steroid hormone ecdysone trigger the major developmental transitions in Drosophila, including molting and puparium formation. The ecdysone signal is transduced by the EcR/USP nuclear receptor heterodimer that binds to specific response elements in the genome and directly regulates target gene transcription. We describe a novel nuclear receptor interacting protein encoded by rigor mortis (rig) that is required for ecdysone responses during larval development. rig mutants display defects in molting, delayed larval development, larval lethality, duplicated mouth parts, and defects in puparium formation--phenotypes that resemble those seen in EcR, usp, E75A and betaFTZ-F1 mutants. Although the expression of these nuclear receptor genes is essentially normal in rig mutant larvae, the ecdysone-triggered switch in E74 isoform expression is defective. rig encodes a protein with multiple WD-40 repeats and an LXXLL motif, sequences that act as specific protein-protein interaction domains. Consistent with the presence of these elements and the lethal phenotypes of rig mutants, Rig protein interacts with several Drosophila nuclear receptors in GST pull-down experiments, including EcR, USP, DHR3, SVP and betaFTZ-F1. The ligand binding domain of betaFTZ-F1 is sufficient for this interaction, which can occur in an AF-2-independent manner. Antibody stains reveal that Rig protein is present in the brain and imaginal discs of second and third instar larvae, where it is restricted to the cytoplasm. In larval salivary gland and midgut cells, however, Rig shuttles between the cytoplasm and nucleus in a spatially and temporally regulated manner, at times that correlate with the major lethal phase of rig mutants and major switches in ecdysone-regulated gene expression. Taken together, these data indicate that rig exerts essential functions during larval development through gene-specific effects on ecdysone-regulated transcription, most likely as a cofactor for one or more

  13. Beyond retrograde and anterograde signalling: mitochondrial-nuclear interactions as a means for evolutionary adaptation and contemporary disease susceptibility.

    Science.gov (United States)

    Ballinger, Scott W

    2013-02-01

    Although there is general agreement that most forms of common disease develop as a consequence of a combination of factors, including genetic, environmental and behavioural contributors, the actual mechanistic basis of how these factors initiate or promote diabetes, cancer, neurodegenerative and cardiovascular diseases in some individuals but not in others with seemingly identical risk factor profiles, is not clearly understood. In this respect, consideration of the potential role for mitochondrial genetics, damage and function in influencing common disease susceptibility seems merited, given that the prehistoric challenges were the original factors that moulded cellular function, and these were based upon the mitochondrial-nuclear relationships that were established during evolutionary history. These interactions were probably refined during prehistoric environmental selection events that, at present, are largely absent. Contemporary risk factors such as diet, sedentary lifestyle and increased longevity, which influence our susceptibility to a variety of chronic diseases were not part of the dynamics that defined the processes of mitochondrial-nuclear interaction, and thus cell function. Consequently, the prehistoric challenges that contributed to cell functionality and evolution should be considered when interpreting and designing experimental data and strategies. Although several molecular epidemiological studies have generally supported this notion, studies that probe beyond these associations are required. Such investigation will mark the initial steps for mechanistically addressing the provocative concept that contemporary human disease susceptibility is the result of prehistoric selection events for mitochondrial-nuclear function, which increased the probability for survival and reproductive success during evolution.

  14. Nuclear proteins interacting with the promoter region of the human granulocyte/macrophage colony-stimulating factor gene

    International Nuclear Information System (INIS)

    Shannon, M.F.; Gamble, J.R.; Vadas, M.A.

    1988-01-01

    The gene for human granulocyte/macrophage colony-stimulating factor (GM-CSF) is expressed in a tissue-specific as well as an activation-dependent manner. The interaction of nuclear proteins with the promoter region of the GM-CSF gene that is likely to be responsible for this pattern of GM-CSF expression was investigated. The authors show that nuclear proteins interact with DNA fragments from the GM-CSF promoter in a cell-specific manner. A region spanning two cytokine-specific sequences, cytokine 1 (CK-1, 5', GAGATTCCAC 3') and cytokine 2 (CK-2, 5' TCAGGTA 3') bound two nuclear proteins from GM-CSF-expressing cells in gel retardation assays. NF-GMb was inducible with phorbol 12-myristate 13-acetate and accompanied induction of GM-CSF message. NF-GMb was absent in cell lines not producing GM-CSF, some of which had other distinct binding proteins. NF-GMa and NF-GMb eluted from a heparin-Sepharose column at 0.3 and 0.6 M KCl, respectively. They hypothesize that the sequences CK-1 and CK-2 bind specific proteins and regulate GM-CSF transcription

  15. Enhancer of rudimentary homologue interacts with scaffold attachment factor B at the nuclear matrix to regulate SR protein phosphorylation.

    Science.gov (United States)

    Drakouli, Sotiria; Lyberopoulou, Aggeliki; Papathanassiou, Maria; Mylonis, Ilias; Georgatsou, Eleni

    2017-08-01

    Scaffold attachment factor B1 (SAFB1) is an integral component of the nuclear matrix of vertebrate cells. It binds to DNA on scaffold/matrix attachment region elements, as well as to RNA and a multitude of different proteins, affecting basic cellular activities such as transcription, splicing and DNA damage repair. In the present study, we show that enhancer of rudimentary homologue (ERH) is a new molecular partner of SAFB1 and its 70% homologous paralogue, scaffold attachment factor B2 (SAFB2). ERH interacts directly in the nucleus with the C-terminal Arg-Gly-rich region of SAFB1/2 and co-localizes with it in the insoluble nuclear fraction. ERH, a small ubiquitous protein with striking homology among species and a unique structure, has also been implicated in fundamental cellular mechanisms. Our functional analyses suggest that the SAFB/ERH interaction does not affect SAFB1/2 function in transcription (e.g. as oestrogen receptor α co-repressors), although it reverses the inhibition exerted by SAFB1/2 on the splicing kinase SR protein kinase 1 (SRPK1), which also binds on the C-terminus of SAFB1/2. Accordingly, ERH silencing decreases lamin B receptor and SR protein phosphorylation, which are major SRPK1 substrates, further substantiating the role of SAFB1 and SAFB2 in the co-ordination of nuclear function. © 2017 Federation of European Biochemical Societies.

  16. Material interactions relating to long-term geologic disposal of nuclear waste glass

    International Nuclear Information System (INIS)

    Bibler, N.E.; Jantzen, C.M.

    1986-01-01

    This review paper systematizes the additional interactions that materials in a geologic repository will impose on the borosilicate glass waste form-groundwater interactions. These materials are the steel canister that holds the glass, the steel overpack over the canister, backfill materials that may be used, and last, the repository host rock. The repository geologies reviewed are tuff, salt, basalt, and granite. The interactions emphasized are those appropriate to conditions expected after repository closure, e.g., oxic vs anoxic conditions. Whenever possible, the effect of radiation from the waste form on the interaction(s) is examined. The interactions are evaluated based on their effect on the release and speciation of various elements including radionuclides from the glass. Repository relevant interactions testing that requires further study before long-term predictions can be made are noted. 62 refs

  17. A Human Nuclear Shuttling Protein That Interacts with Human Immunodeficiency Virus Type 1 Matrix Is Packaged into Virions

    Science.gov (United States)

    Gupta, Kalpana; Ott, David; Hope, Thomas J.; Siliciano, Robert F.; Boeke, Jef D.

    2000-01-01

    Active nuclear import of the human immunodeficiency virus type 1 (HIV-1) preintegration complex (PIC) is essential for the productive infection of nondividing cells. Nuclear import of the PIC is mediated by the HIV-1 matrix protein, which also plays several critical roles during viral entry and possibly during virion production facilitating the export of Pr55Gag and genomic RNA. Using a yeast two-hybrid screen, we identified a novel human virion-associated matrix-interacting protein (VAN) that is highly conserved in vertebrates and expressed in most human tissues. Its expression is upregulated upon activation of CD4+ T cells. VAN is efficiently incorporated into HIV-1 virions and, like matrix, shuttles between the nucleus and cytoplasm. Furthermore, overexpression of VAN significantly inhibits HIV-1 replication in tissue culture. We propose that VAN regulates matrix nuclear localization and, by extension, both nuclear import of the PIC and export of Pr55Gag and viral genomic RNA during virion production. Our data suggest that this regulatory mechanism reflects a more global process for regulation of nucleocytoplasmic transport. PMID:11090181

  18. Measurement of pion and proton response and longitudinal shower profiles up to 20 nuclear interaction lengths with the ATLAS Tile calorimeter

    Czech Academy of Sciences Publication Activity Database

    Adragna, P.; Alexa, C.; Anderson, K.; Lokajíček, Miloš; Němeček, Stanislav; Přibyl, Lukáš

    2010-01-01

    Roč. 615, č. 2 (2010), s. 158-181 ISSN 0168-9002 R&D Projects: GA MŠk LA08032 Institutional research plan: CEZ:AV0Z10100502 Keywords : ATLAS * calorimetry * test-beam * Monte Carlo simulation * GEANT4 * hadronic shower development * pion–proton response Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 1.142, year: 2010 http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TJM-4Y95RDG-1&_user=625012&_coverDate=04%2F01%2F2010&_alid=1542842401&_rdoc=19&_fmt=high&_o

  19. Short Rayleigh Length Free Electron Lasers

    CERN Document Server

    Crooker, P P; Armstead, R L; Blau, J

    2004-01-01

    Conventional free electron laser (FEL) oscillators minimize the optical mode volume around the electron beam in the undulator by making the resonator Rayleigh length about one third of the undulator length. This maximizes gain and beam-mode coupling. In compact configurations of high-power infrared FELs or moderate power UV FELs, the resulting optical intensity can damage the resonator mirrors. To increase the spot size and thereby reduce the optical intensity at the mirrors below the damage threshold, a shorter Rayleigh length can be used, but the FEL interaction is significantly altered. A new FEL interaction is described and analyzed with a Rayleigh length that is only one tenth the undulator length, or less. The effect of mirror vibration and positioning are more critical in the short Rayleigh length design, but we find that they are still within normal design tolerances.

  20. Interaction of nucleosome assembly proteins abolishes nuclear localization of DGK{zeta} by attenuating its association with importins

    Energy Technology Data Exchange (ETDEWEB)

    Okada, Masashi; Hozumi, Yasukazu [Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata 990-9585 (Japan); Ichimura, Tohru [Department of Chemistry, Graduate School of Sciences and Engineering, Tokyo Metropolitan University, Hachioji 192-0397 (Japan); Tanaka, Toshiaki; Hasegawa, Hiroshi; Yamamoto, Masakazu; Takahashi, Nobuya [Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata 990-9585 (Japan); Iseki, Ken [Department of Emergency and Critical Care Medicine, Yamagata University School of Medicine, Yamagata 990-9585 (Japan); Yagisawa, Hitoshi [Laboratory of Biological Signaling, Graduate School of Life Science, University of Hyogo, Hyogo 678-1297 (Japan); Shinkawa, Takashi; Isobe, Toshiaki [Department of Chemistry, Graduate School of Sciences and Engineering, Tokyo Metropolitan University, Hachioji 192-0397 (Japan); Goto, Kaoru, E-mail: kgoto@med.id.yamagata-u.ac.jp [Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata 990-9585 (Japan)

    2011-12-10

    Diacylglycerol kinase (DGK) is involved in the regulation of lipid-mediated signal transduction through the metabolism of a second messenger diacylglycerol. Of the DGK family, DGK{zeta}, which contains a nuclear localization signal, localizes mainly to the nucleus but translocates to the cytoplasm under pathological conditions. However, the detailed mechanism of translocation and its functional significance remain unclear. To elucidate these issues, we used a proteomic approach to search for protein targets that interact with DGK{zeta}. Results show that nucleosome assembly protein (NAP) 1-like 1 (NAP1L1) and NAP1-like 4 (NAP1L4) are identified as novel DGK{zeta} binding partners. NAP1Ls constitutively shuttle between the nucleus and the cytoplasm in transfected HEK293 cells. The molecular interaction of DGK{zeta} and NAP1Ls prohibits nuclear import of DGK{zeta} because binding of NAP1Ls to DGK{zeta} blocks import carrier proteins, Qip1 and NPI1, to interact with DGK{zeta}, leading to cytoplasmic tethering of DGK{zeta}. In addition, overexpression of NAP1Ls exerts a protective effect against doxorubicin-induced cytotoxicity. These findings suggest that NAP1Ls are involved in a novel molecular basis for the regulation of nucleocytoplasmic shuttling of DGK{zeta} and provide a clue to examine functional significance of its translocation under pathological conditions.

  1. Identification of interacting proteins of retinoid-related orphan nuclear receptor gamma in HepG2 cells

    Directory of Open Access Journals (Sweden)

    Ze-Min Huang1,#, Jun Wu2,#, Zheng-Cai Jia1, Yi Tian1, Jun Tang3, Yan Tang1, Ying Wang2, Yu-Zhang Wu1,* & Bing Ni1,*

    2012-06-01

    Full Text Available The retinoid-related orphan nuclear receptor gamma (RORγplays critical roles in regulation of development, immunity andmetabolism. As transcription factor usually forms a proteincomplex to function, thus capturing and dissecting of theRORγ protein complex will be helpful for exploring themechanisms underlying those functions. After construction ofthe recombinant tandem affinity purification (TAP plasmid,pMSCVpuro RORγ-CTAP(SG, the nuclear localization ofRORγ-CTAP(SG fusion protein was verified. Followingisolation of RORγ protein complex by TAP strategy, sevencandidate interacting proteins were identified. Finally, the heatshock protein 90 (HSP90 and receptor-interacting protein 140(RIP140 were confirmed to interplay with RORγ byco-immunoprecipitation. Interference of HSP90 or/and RIP140genes resulted in dramatically decreased expression ofCYP2C8 gene, the RORγ target gene. Data from this studydemonstrate that HSP90 and RIP140 proteins interact withRORγ protein in a complex format and function asco-activators in the RORγ-mediated regulatory processes ofHepG2 cells.

  2. Electron-nuclear interaction in 13C nanotube double quantum dots

    DEFF Research Database (Denmark)

    Churchill, H O H; Bestwick, A J; Harlow, J W

    2009-01-01

    For coherent electron spins, hyperfine coupling to nuclei in the host material can either be a dominant source of unwanted spin decoherence or, if controlled effectively, a resource enabling storage and retrieval of quantum information. To investigate the effect of a controllable nuclear...... environment on the evolution of confined electron spins, we have fabricated and measured gate-defined double quantum dots with integrated charge sensors made from single-walled carbon nanotubes with a variable concentration of 13C (nuclear spin I=1/2) among the majority zero-nuclear-spin 12C atoms. We observe...... strong isotope effects in spin-blockaded transport, and from the magnetic field dependence estimate the hyperfine coupling in 13C nanotubes to be of the order of 100 ¿µeV, two orders of magnitude larger than anticipated. 13C-enhanced nanotubes are an interesting system for spin-based quantum information...

  3. Identification of a novel receptor-like protein kinase that interacts with a geminivirus nuclear shuttle protein

    International Nuclear Information System (INIS)

    Mariano, Andrea C.; Andrade, Maxuel O.; Santos, Anesia A.; Carolino, Sonia M.B.; Oliveira, Marli L.; Baracat-Pereira, Maria Cristina; Brommonshenkel, Sergio H.; Fontes, Elizabeth P.B.

    2004-01-01

    Despite extensive studies in plant virus-host interactions, the molecular mechanisms of geminivirus movement and interactions with host components remain largely unknown. A tomato kinase protein and its soybean homolog were found to interact specifically with the nuclear shuttle protein (NSP) of Tomato golden mosaic virus (TGMV) and Tomato crinkle leaf yellows virus (TCrLYV) through yeast two-hybrid screening and in vitro protein binding assays. These proteins, designated LeNIK (Lycopersicon esculentum NSP-Interacting Kinase) and GmNIK (Glycine max NIK), belong to the LRR-RLK (leucine rich-repeat receptor-like kinase) family that is involved in plant developmental processes and/or resistance response. As such, NIK is structurally organized into characteristic domains, including a serine/threonine kinase domain with a nucleotide binding site at the C-terminal region, an internal transmembrane segment and leucine-rich repeats (LRR) at the N-terminal portion. The potential significance of the NSP-NIK interaction is discussed

  4. Nitrosative/oxidative stress conditions regulate thioredoxin-interacting protein (TXNIP) expression and thioredoxin-1 (TRX-1) nuclear localization.

    Science.gov (United States)

    Ogata, Fernando Toshio; Batista, Wagner Luiz; Sartori, Adriano; Gesteira, Tarsis Ferreira; Masutani, Hiroshi; Arai, Roberto Jun; Yodoi, Junji; Stern, Arnold; Monteiro, Hugo Pequeno

    2013-01-01

    Thioredoxin (TRX-1) is a multifunctional protein that controls the redox status of other proteins. TRX-1 can be found in the extracellular milieu, cytoplasm and nucleus, and it has distinct functions in each environment. Previously, we studied the intracellular localization of TRX-1 and its relationship with the activation of the p21Ras-ERK1/2 MAP Kinases signaling pathway. In situations where this pathway was activated by stress conditions evoked by a nitrosothiol, S-nitroso-N-acetylpenicillamine (SNAP), TRX-1 accumulated in the nuclear compartment due to nitrosylation of p21Ras and activation of downstream ERK1/2 MAP kinases. Presently, we demonstrate that ERK1/2 MAP Kinases activation and spatial distribution within cells trigger TRX-1 nuclear translocation through down-regulation of the physiological inhibitor of TRX-1, Thioredoxin Interacting Protein (TXNIP). Once activated by the oxidants, SNAP and H₂O₂, the ERK1/2 MAP kinases migrate to the nucleus. This is correlated with down-regulation of TXNIP. In the presence of the MEK inhibitors (PD98059 or UO126), or in cells transfected with the Protein Enriched in Astrocytes (PEA-15), a cytoplasmic anchor of ERK1/2 MAP kinases, TRX-1 nuclear migration and TXNIP down-regulation are no longer observed in cells exposed to oxidants. On the other hand, over-expression of TXNIP abolishes nuclear migration of TRX-1 under nitrosative/oxidative stress conditions, whereas gene silencing of TXNIP facilitates nuclear migration even in the absence of stress conditions. Studies based on the TXNIP promoter support this regulation. In conclusion, changes in TRX-1 compartmentalization under nitrosative/oxidative stress conditions are dependent on the expression levels of TXNIP, which are regulated by cellular compartmentalization and activation of the ERK1/2 MAP kinases.

  5. Nitrosative/oxidative stress conditions regulate thioredoxin-interacting protein (TXNIP expression and thioredoxin-1 (TRX-1 nuclear localization.

    Directory of Open Access Journals (Sweden)

    Fernando Toshio Ogata

    Full Text Available Thioredoxin (TRX-1 is a multifunctional protein that controls the redox status of other proteins. TRX-1 can be found in the extracellular milieu, cytoplasm and nucleus, and it has distinct functions in each environment. Previously, we studied the intracellular localization of TRX-1 and its relationship with the activation of the p21Ras-ERK1/2 MAP Kinases signaling pathway. In situations where this pathway was activated by stress conditions evoked by a nitrosothiol, S-nitroso-N-acetylpenicillamine (SNAP, TRX-1 accumulated in the nuclear compartment due to nitrosylation of p21Ras and activation of downstream ERK1/2 MAP kinases. Presently, we demonstrate that ERK1/2 MAP Kinases activation and spatial distribution within cells trigger TRX-1 nuclear translocation through down-regulation of the physiological inhibitor of TRX-1, Thioredoxin Interacting Protein (TXNIP. Once activated by the oxidants, SNAP and H₂O₂, the ERK1/2 MAP kinases migrate to the nucleus. This is correlated with down-regulation of TXNIP. In the presence of the MEK inhibitors (PD98059 or UO126, or in cells transfected with the Protein Enriched in Astrocytes (PEA-15, a cytoplasmic anchor of ERK1/2 MAP kinases, TRX-1 nuclear migration and TXNIP down-regulation are no longer observed in cells exposed to oxidants. On the other hand, over-expression of TXNIP abolishes nuclear migration of TRX-1 under nitrosative/oxidative stress conditions, whereas gene silencing of TXNIP facilitates nuclear migration even in the absence of stress conditions. Studies based on the TXNIP promoter support this regulation. In conclusion, changes in TRX-1 compartmentalization under nitrosative/oxidative stress conditions are dependent on the expression levels of TXNIP, which are regulated by cellular compartmentalization and activation of the ERK1/2 MAP kinases.

  6. Anisotropy of the nuclear magnetic relaxation times induced in solid 3He by modulation of the dipolar interactions

    International Nuclear Information System (INIS)

    Deville, G.

    1976-01-01

    Anisotropic nuclear relaxation times have been measured in solid 3 He samples grown at constant pressure, in the Larmor frequency range 1.5MHz-5MHz where the main relaxation mechanism is the modulation of the dipolar interaction by exchange or by motion of the vacancies. The second order calculation made by Harris for the exchange induced relaxation regime is extended to the regime where vacancy motion dominates. The theory is further refined by considering the fourth moment anisotropy effect on the spectral densities. This latter calculation yields a frequency dependent anisotropic contribution to T 1 which agrees qualitatively with the data, unlike the simpler results by Harris [fr

  7. Hyperfine interaction with polarized atomic environment - the nuclear tilted-foil experiment

    International Nuclear Information System (INIS)

    Niv, Y.

    1985-01-01

    The nuclear tilted-foil experimental field has matured from the early time-integral measurements to the current multifoil time-differential precession and polarization configurations, leading to a wide range of measurements - magnetic moments, quadrupole moments and parity-non-conservation. The physical basis of these experiments is discussed and experimental results are reviewed. (Auth.)

  8. A method to remove virtual interactions with applications to nuclear spectroscopy

    International Nuclear Information System (INIS)

    Bengtsson, T.

    1988-12-01

    A general method to ensure that the wave-functions develop smoothly when a parameter in the Hamiltonian is gradually chaning is described. The method is exemplified by calculations of nuclear shape coexistence in 186 Pb and highspin band structure in 165 Yb. (30 refs.)

  9. Theoretical aspects of electroweak and other interactions in medium-energy nuclear physics: Final progress report

    International Nuclear Information System (INIS)

    Mukhopadhyay, N.C.

    1987-01-01

    The contracted project deals with the theory of photo- and electroproduction of mesons from nucleons and nuclei, electromagnetic structure of baryons and search for axions in nuclear and particle physics. The principal investigator has been a member of the CEBAF steering committee on the research on excited baryons

  10. Human-machine interactions: The human element of expert systems for the nuclear industry

    International Nuclear Information System (INIS)

    Nelson, W.R.

    1989-01-01

    This paper will begin with a brief history of the development of expert systems in the nuclear industry. This discussion will serve to provide the reader with an understanding of how the field of artificial intelligence (AI) applications in the nuclear industry has developed. Next, this paper will discuss the general human factors issues relative to the development and implementation of expert systems for the nuclear industry. It will summarize the relevant research that addresses these issues and identify those areas that need the most effort for success. Since much of the prominent work for the application of expert systems has focused on computerized aids for decisionmaking in emergencies, this paper will draw from this area for its examples. This area tends to highlight the issues because of the safety-critical nature of the application. The same issues, however, are relevant to other applications of expert systems in the nuclear industry as well, even though the consequences of failure may not be as dramatic. (orig./GL)

  11. The molecular mechanism of bisphenol A (BPA as an endocrine disruptor by interacting with nuclear receptors: insights from molecular dynamics (MD simulations.

    Directory of Open Access Journals (Sweden)

    Lanlan Li

    Full Text Available Bisphenol A (BPA can interact with nuclear receptors and affect the normal function of nuclear receptors in very low doses, which causes BPA to be one of the most controversial endocrine disruptors. However, the detailed molecular mechanism about how BPA interferes the normal function of nuclear receptors is still undiscovered. Herein, molecular dynamics simulations were performed to explore the detailed interaction mechanism between BPA with three typical nuclear receptors, including hERα, hERRγ and hPPARγ. The simulation results and calculated binding free energies indicate that BPA can bind to these three nuclear receptors. The binding affinities of BPA were slightly lower than that of E2 to these three receptors. The simulation results proved that the binding process was mainly driven by direct hydrogen bond and hydrophobic interactions. In addition, structural analysis suggested that BPA could interact with these nuclear receptors by mimicking the action of natural hormone and keeping the nuclear receptors in active conformations. The present work provided the structural evidence to recognize BPA as an endocrine disruptor and would be important guidance for seeking safer substitutions of BPA.

  12. About possibility of creation of ecologically pure, safe nuclear power plants on the basis of high-effective resonant neutron interaction with splitting substances

    International Nuclear Information System (INIS)

    Irdyncheyev, L.A.; Malofeyev, A.M.; Frid, E.S.; Abramov, E.P.

    1993-01-01

    Currently the most important problem in nuclear engineering is creation of ecologically pure, safe nuclear power plants in the context of real danger of global ecological pollution of the environment with long-lived fission products and the resultant transuranium nuclides. The problem can be solved by creating nuclear power plants on the basis of high-effective resonant interaction (HERI). Such power plants would provide the total cycle, including nuclear fuel production (Plutonium-239 from Uranium-238), combustion and waste products salvaging by way of transformation of radioactive nuclides into stable isotopes

  13. Nuclear

    International Nuclear Information System (INIS)

    Anon.

    2000-01-01

    The first text deals with a new circular concerning the collect of the medicine radioactive wastes, containing radium. This campaign wants to incite people to let go their radioactive wastes (needles, tubes) in order to suppress any danger. The second text presents a decree of the 31 december 1999, relative to the limitations of noise and external risks resulting from the nuclear facilities exploitation: noise, atmospheric pollution, water pollution, wastes management and fire prevention. (A.L.B.)

  14. Microscopy based studies on the interaction of bio-based silver nanoparticles with Bombyx mori Nuclear Polyhedrosis virus.

    Science.gov (United States)

    Tamilselvan, Selvaraj; Ashokkumar, Thirunavukkarasu; Govindaraju, Kasivelu

    2017-04-01

    In the present investigation, silver nanoparticles (AgNPs) interactions with Bombyx mori Nuclear Polyhedrosis virus (BmNPV) were characterized using High-Resolution Scanning Electron Microscopy (HR-SEM), Energy Dispersive X-ray Analysis (EDAX), Transmission Electron Microscopy (TEM), Atomic Force Microcopy (AFM) and Confocal Microscope (CM). HR-SEM study reveals that the biosynthesized AgNPs have interacted with BmNPV and were found on the surface. TEM micrographs of normal and viral polyhedra treated with AgNPs showed that the nanoparticles were accumulated in the membrane and it was noted that some of the AgNPs successfully penetrated the membrane by reaching the capsid of BmNPV. AFM and confocal microscopy studies reveal that the disruption in the shell membrane tends to lose its stability due to exposure of AgNPs to BmNPV. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. Interactions of hadrons in nuclear emulsion in the energy range 60 GeV - 400 GeV

    International Nuclear Information System (INIS)

    Holynski, R.

    1986-01-01

    Interactions of pions and protons in the energy range 60 GeV in nuclear emulsion have been analysed. The fragmentation process of the struck nucleus as well as the multiple production of relativistic particles have been investigated as a function of the primary energy and the effective thickness of the target. It is shown that both, the fragmentation of the target nucleus and particle production, can be described by models in which the projectile (or its constituents) undergoes multiple collisions inside the target nucleus. In particular the particle production in the projectile fragmentation region in pion-nucleus interactions is well described by the additive quark model. 47 refs., 35 figs., 2 tabs. (author)

  16. Single nuclear transfer strengths and sum rules in the interacting boson-fermion model and in the spectral averaging theory

    International Nuclear Information System (INIS)

    Kota, V.K.B.

    1991-01-01

    In the interacting boson-fermion model of collective nuclei, in the symmetry limits of the model appropriate for vibrational, rotational and γ-unstable nuclei, for one-particle transfer, the selection rules, model predictions for the allowed strengths and comparison of theory with experiment are briefly reviewed. In the spectral-averaging theory, with the specific example of orbit occupancies, the smoothed forms (linear or better ratio of Gaussians) as determined by central limit theorems, how they provide a good criterion for selecting effective interactions and the convolution structure of occupancy densities in huge spaces are described. Complementary information provided by nuclear models and statistical laws is broughtout. (author). 63 refs., 5 figs

  17. Methodological developments of low field MRI: Elasto-graphy, MRI-ultrasound interaction and dynamic nuclear polarization

    International Nuclear Information System (INIS)

    Madelin, Guillaume

    2005-01-01

    This thesis deals with two aspects of low field (0.2 T) Magnetic Resonance Imaging (MRI): the research of new contrasts due to the interaction between Nuclear Magnetic Resonance (NMR) and acoustics (elasto-graphy, spin-phonon interaction) and enhancement of the signal-to-noise ratio by Dynamic Nuclear Polarization (DNP). Magnetic Resonance Elasto-graphy (MRE) allows to assess some viscoelastic properties of tissues by visualization of the propagation of low frequency acoustic strain waves. A review on MRE is given, as well as a study on local measurement of the acoustic absorption coefficient. The next part is dedicated to MRI-ultrasound interaction. First, the ultrasonic transducer was calibrated for power and acoustic field using the comparison of two methods: the radiation force method (balance method) and laser interferometry. Then, we tried to modify the T1 contrast of tissues by spin-phonon interaction due to the application of ultrasound at the resonance frequency at 0.2 T, which is about 8.25 MHz. No modification of T1 contrast has been obtained, but the acoustic streaming phenomenon has been observed in liquids. MRI visualization of this streaming could make possible to calibrate transducers as well as to assess some mechanical properties of viscous fluids. The goal of the last part was to set up DNP experiments at 0.2 T in order to enhance the NMR signal. This double resonance method is based on the polarization transfer of unpaired electrons of free radicals to the surrounding protons of water. This transfer occurs by cross relaxation during the saturation of an electronic transition using Electronic Paramagnetic Resonance (EPR). Two EPR cavities operating at 5.43 GHz have been tested on oxo-TEMPO free radicals (nitroxide). An enhancement of the NMR signal by a factor 30 was obtained during these preliminary experiments. (author)

  18. Telomere length analysis.

    Science.gov (United States)

    Canela, Andrés; Klatt, Peter; Blasco, María A

    2007-01-01

    Most somatic cells of long-lived species undergo telomere shortening throughout life. Critically short telomeres trigger loss of cell viability in tissues, which has been related to alteration of tissue function and loss of regenerative capabilities in aging and aging-related diseases. Hence, telomere length is an important biomarker for aging and can be used in the prognosis of aging diseases. These facts highlight the importance of developing methods for telomere length determination that can be employed to evaluate telomere length during the human aging process. Telomere length quantification methods have improved greatly in accuracy and sensitivity since the development of the conventional telomeric Southern blot. Here, we describe the different methodologies recently developed for telomere length quantification, as well as their potential applications for human aging studies.

  19. Study of nuclear interactions of 400 GeV protons in emulsion

    International Nuclear Information System (INIS)

    Otterlund, I.; Kullberg, R.; Stenlund, E.; Andersson, B.; Nilsson, G.; Kim, C.O.; Lorry, J.; Meton, C.; Schune, D.; Chu, T.; Villot, B.; Kaiser, R.; Vincent, M.A.; Baumann, G.; Devienne, R.; Schmitt, R.; Adamovic, O.; Juric, M.; Bolta, J.M.; Sanchis, M.A.; Bravo, L.; Niembro, R.; Ruiz, A.; Villar, E.

    1977-05-01

    400 GeV inelastic proton-emulsion nucleus interactions from an International Emulsion Group experiment at Fermilab are reported. The results are compared with the corresponding data at 67-300 GeV. (Auth.)

  20. Evaluation of soil damping techniques used in soil structure interaction analysis of a nuclear power plant

    International Nuclear Information System (INIS)

    Nelson, T.A.

    1982-01-01

    A prediction of dynamic soil properties at the site of a nuclear power plant plays a very important role in the seismic analysis of the facility. Conventional modal analysis procedures can accommodate virtually any range of equivalent elastic soil stiffness which is used to characterize the site. However, high radiation damping associated with energy dissipation in the soil half-space is difficult to accommodate in an elastic modal solution to the dynamic problem. Several methods are available to combine the soil damping with the structural damping in a composite modal damping coefficient. However, even with this convenient representation, the resulting large fractions of critical damping can make modal solutions to the problems suspect. This paper is based on experience gained in this area during studies performed for the Nuclear Regulatory Commission involving seismic analyses of power plants

  1. Interactions of cullin3/KCTD5 complexes with both cytoplasmic and nuclear proteins: Evidence for a role in protein stabilization

    Energy Technology Data Exchange (ETDEWEB)

    Rutz, Natalja; Heilbronn, Regine; Weger, Stefan, E-mail: stefan.weger@charite.de

    2015-08-28

    Based on its specific interaction with cullin3 mediated by an N-terminal BTB/POZ homologous domain, KCTD5 has been proposed to function as substrate adapter for cullin3 based ubiquitin E3 ligases. In the present study we tried to validate this hypothesis through identification and characterization of additional KCTD5 interaction partners. For the replication protein MCM7, the zinc finger protein ZNF711 and FAM193B, a yet poorly characterized cytoplasmic protein, we could demonstrate specific interaction with KCTD5 both in yeast two-hybrid and co-precipitation studies in mammalian cells. Whereas trimeric complexes of cullin3 and KCTD5 with the respective KCTD5 binding partner were formed, KCTD5/cullin3 induced polyubiquitylation and/or proteasome-dependent degradation of these binding partners could not be demonstrated. On the contrary, KCTD5 or Cullin3 overexpression increased ZNF711 protein stability. - Highlights: • KCTD5 nuclear translocation depends upon M phase and protein oligomerization. • Identification of MCM7, ZNF711 and FAM193 as KCTD5 interaction partners. • Formation of trimeric complexes of KCTD5/cullin3 with MCM7, ZNF711 and FAM193B. • KCTD5 is not involved in polyubiquitylation of MCM7 replication factor. • The KCTD5/cullin3 complex stabilizes ZNF711 transcription factor.

  2. Interactions of 10.6 GeV/n gold nuclei with light and heavy target nuclei in nuclear emulsion

    International Nuclear Information System (INIS)

    Cherry, M.L.; Denes-Jones, P.

    1994-03-01

    We have investigated the particle production and fragmentation of nuclei participating in the interactions of 10.6 GeV/n gold nuclei in nuclear emulsions. A new criteria has been developed to distinguish between the interactions of these gold nuclei with the light (H, C, N, O) and heavy (Ag, Br) target nuclei in the emulsion. This has allowed separate analyzes of the multiplicity and pseudo-rapidity distributions of the singly charged particles emitted in Au-(H, C, N, O) and Au-(Ag, Br) interactions, as well as of the models of breakup of the projectile and target nuclei. The pseudo-rapidity distributions show strong forward asymmetries, particularly for the interactions with the light nuclei. Heavy target nuclei produce a more severe breakup of the projectile gold nucleus than do the lighter targets. A negative correlation between the number of fragments emitted from the target nuclei and the degree of centrality of the collisions has been observed, which can be attributed to the total destruction of the relatively light target nuclei by these very heavy projectile nuclei. (author). 14 refs, 11 figs, 1 tab

  3. Experimental and analytical studies for a BWR nuclear reactor building. Evaluation of soil-structure interaction behaviour

    International Nuclear Information System (INIS)

    Mizuno, N.; Tsushima, Y.

    1975-01-01

    This paper evaluates the spatial characteristics of dynamic properties, especially soil-structure interaction behaviour, of the BWR nuclear building by experimental and analytical studies. It is well known that the damping effects in soil-structure interaction are remarkable on the building with short periods by the dissipation of vibrational energy to the soil. The authors have previously reported an analytical method for estimating the damping effects the properties of which are characterized as follows: 1) The complex damping is used, because the so-called structural damping may be more suitable for estimating the damping effects of an elastic structure. 2) H. Tajimi's theory is used for estimating the dynamical soil-foundation stiffness with the dissipation of vibrational energy on the elastic half-space soil. In this paper, an approximate explanation is presented in regard to the more developmental mathematical method for estimating the damping effects than the above-mentioned previous method, which is 'Modes Superposition Method for Multi-Degrees of Freedom System' with the constant complex stiffness showing the structural damping effects and the dynamical soil-foundation stiffness approximated by the linear or quadratic functions of the eigenvalues. An approximate explanation is presented in regard to the experimental results of the No. 1 reactor building (BWR) of Hamaoka Nuclear Power Station, The Chubu Electric Power Co., Ltd. (Auth.)

  4. ISINN-5. 5. International seminar on interaction of neutrons with nuclei. Neutron spectroscopy, nuclear structure, related topics

    International Nuclear Information System (INIS)

    1997-01-01

    The materials submitted at the fifth in a series of annual international seminar on interaction of neutrons with nuclei Neutron Spectroscopy, Nuclear Structure, Related Topics (ISINN-5) are given. The Seminar is organized by the Frank Laboratory of Neutron Physics of the Joint Institute for Nuclear Research and took place in Dubna on May 14-17, 1997. About 130 specialists from Belgium, China, Germany, France, Japan, Korea, Latvia, Netherlands, Ukraine, 7 Russian research institutes and a number of JINR laboratories took part in the Seminar. The scope of the problems discussed is traditionally wide. It includes the problems of violation of fundamental symmetries in the interaction of neutrons with nuclei, the properties of the neutron as the fundamental particle, nonstatistical aspects of the radiation capture of neutrons by nuclei, topical problems of the theory of nucleus, and the fission mechanism of heavy nuclei. The latest results obtained with ultracold neutrons (UCN), in particular, different approaches to understanding of the cause of UCN anomalous leakage through the walls of the trap are considered as well. The wide spectrum of methodological aspects of neutron-aided experiments is also discussed in details

  5. Interaction of Sp1 zinc finger with transport factor in the nuclear localization of transcription factor Sp1

    International Nuclear Information System (INIS)

    Ito, Tatsuo; Kitamura, Haruka; Uwatoko, Chisana; Azumano, Makiko; Itoh, Kohji; Kuwahara, Jun

    2010-01-01

    Research highlights: → Sp1 zinc fingers themselves interact with importin α. → Sp1 zinc finger domains play an essential role as a nuclear localization signal. → Sp1 can be transported into the nucleus in an importin-dependent manner. -- Abstract: Transcription factor Sp1 is localized in the nucleus and regulates the expression of many cellular genes, but the nuclear transport mechanism of Sp1 is not well understood. In this study, we revealed that GST-fused Sp1 protein bound to endogenous importin α in HeLa cells via the Sp1 zinc finger domains, which comprise the DNA binding domain of Sp1. It was found that the Sp1 zinc finger domains directly interacted with a wide range of importin α including the armadillo (arm) repeat domain and the C-terminal acidic domain. Furthermore, it turned out that all three zinc fingers of Sp1 are essential for binding to importin α. Taken together, these results suggest that the Sp1 zinc finger domains play an essential role as a NLS and Sp1 can be transported into the nucleus in an importin-dependent manner even though it possesses no classical NLSs.

  6. Stabilities of nuclear waste forms and their geochemical interactions in repositories

    International Nuclear Information System (INIS)

    White, W.B.

    1980-01-01

    The stabilities of high-level nuclear waste forms in a repository environment are briefly discussed. The advantages and disadvantages of such waste forms as borosilicate glass, supercalcine ceramics, and synthetic minerals are presented in context with the different rock types which have been proposed as possible host rocks for repositories. It is concluded that the growing geochemical evidence favors the use of a silicate rock repository because of the effectiveness of aluminosilicate rocks as chemical barriers for most radionuclides

  7. Interaction of HTLV-1 Tax protein with the calreticulin: Implications for Tax nuclear export and secretion

    OpenAIRE

    Alefantis, Timothy; Flaig, Katherine E.; Wigdahl, Brian; Jain, Pooja

    2007-01-01

    Human T cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 transcriptional transactivator protein Tax plays an integral role in virus replication and disease progression. Traditionally, Tax is described as a nuclear protein where it performs its primary role as a transcriptional transactivator. However, recent studies have clearly shown that Tax can also be localized to t...

  8. Interaction between control and acceptance of nuclear energy in Switzerland. Aims and implementation

    International Nuclear Information System (INIS)

    Zangger, C.

    1977-01-01

    In Switzerland four Federal laws are involved in controlling nuclear energy, two of which are on the cantonal level. These four laws have entailed three different licensing procedures, of which two are cantonal. Even though these laws together cover all aspects of the protection of man, the environment and the countryside, which must be examined for each individual project, nevertheless: (a) the legal situation and the overall licensing system are complex - they are not easily understood by the man in the street and offer a lawyer numerous possibilities for bringing in appeals; (b) decisions affecting the three licensing procedures are taken at different levels; and (c) the nuclear law contains a clause obliging the Federal authorities to treat information on the nuclear aspects of projects confidentially, thus limiting access by the citizen to such information. Although this state of affairs has not appreciably influenced acceptance by the population living near the two operating power plants and the two that are under construction, it has led, in the case of two of the five new projects, to consistently mounting opposition on the part of the local population, opposition which in some cases has reached a very high pitch. In 1975, there was one case where the site was occupied for several months, a violation of the law. Similarly, the opposition which was latent in the rest of Switzerland until two years ago has reached the stage of initiatives, and a ''Federal popular initiative to safeguard the people's rights and safety during the construction and operation of atomic facilities'' has been launched. This initiative, which demands in particular that powers of decision by means of a vote should be accorded to the local population, is prompting the Federal authorities to take legislative action. A Federal commission of legal experts is at present working on a revision of the nuclear law; the proposed modifications are set out and discussed in the paper. (author)

  9. Safety and Nonsafety Communications and Interactions in International Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Kisner, Roger A [ORNL; Mullens, James Allen [ORNL; Wilson, Thomas L [ORNL; Wood, Richard Thomas [ORNL; Korsah, Kofi [ORNL; Qualls, A L [ORNL; Muhlheim, Michael David [ORNL; Holcomb, David Eugene [ORNL; Loebl, Andy [ORNL

    2007-08-01

    Current industry and NRC guidance documents such as IEEE 7-4.3.2, Reg. Guide 1.152, and IEEE 603 do not sufficiently define a level of detail for evaluating interdivisional communications independence. The NRC seeks to establish criteria for safety systems communications that can be uniformly applied in evaluation of a variety of safety system designs. This report focuses strictly on communication issues related to data sent between safety systems and between safety and nonsafety systems. Further, the report does not provide design guidance for communication systems nor present detailed failure modes and effects analysis (FMEA) results for existing designs. This letter report describes communications between safety and nonsafety systems in nuclear power plants outside the United States. A limited study of international nuclear power plants was conducted to ascertain important communication implementations that might have bearing on systems proposed for licensing in the United States. This report provides that following information: 1.communications types and structures used in a representative set of international nuclear power reactors, and 2.communications issues derived from standards and other source documents relevant to safety and nonsafety communications. Topics that are discussed include the following: communication among redundant safety divisions, communications between safety divisions and nonsafety systems, control of safety equipment from a nonsafety workstation, and connection of nonsafety programming, maintenance, and test equipment to redundant safety divisions during operation. Information for this report was obtained through publicly available sources such as published papers and presentations. No proprietary information is represented.

  10. Intelligent and interactive computer image of a nuclear power plant: The ImagIn project

    International Nuclear Information System (INIS)

    Haubensack, D.; Malvache, P.; Valleix, P.

    1998-01-01

    The ImagIn project consists in a method and a set of computer tools apt to bring perceptible and assessable improvements in the operational safety of a nuclear plant. Its aim is to design an information system that would maintain a highly detailed computerized representation of a nuclear plant in its initial state and throughout its in-service life. It is not a tool to drive or help driving the nuclear plant, but a tool that manages concurrent operations that modify the plant configuration in a very general was (maintenance for example). The configuration of the plant, as well as rules and constraints about it, are described in a object-oriented knowledge database, which is built using a generic ImagIn meta-model based on the semantical network theory. An inference engine works on this database and is connected to reality through interfaces to operators and captors on the installation; it verifies constantly in real-time the consistency of the database according to its inner rules, and reports eventual problems to concerned operators. A special effort is made on interfaces to provide natural and intuitive tools (using virtual reality, natural language, voice recognition and synthesis). A laboratory application on a fictive but realistic installation already exists and is used to simulate various tests and scenarii. A real application is being constructed on Siloe, an experimental reactor of the CEA. (author)

  11. Plasticity of an ultrafast interaction between nucleoporins and nuclear transport receptors.

    Science.gov (United States)

    Milles, Sigrid; Mercadante, Davide; Aramburu, Iker Valle; Jensen, Malene Ringkjøbing; Banterle, Niccolò; Koehler, Christine; Tyagi, Swati; Clarke, Jane; Shammas, Sarah L; Blackledge, Martin; Gräter, Frauke; Lemke, Edward A

    2015-10-22

    The mechanisms by which intrinsically disordered proteins engage in rapid and highly selective binding is a subject of considerable interest and represents a central paradigm to nuclear pore complex (NPC) function, where nuclear transport receptors (NTRs) move through the NPC by binding disordered phenylalanine-glycine-rich nucleoporins (FG-Nups). Combining single-molecule fluorescence, molecular simulations, and nuclear magnetic resonance, we show that a rapidly fluctuating FG-Nup populates an ensemble of conformations that are prone to bind NTRs with near diffusion-limited on rates, as shown by stopped-flow kinetic measurements. This is achieved using multiple, minimalistic, low-affinity binding motifs that are in rapid exchange when engaging with the NTR, allowing the FG-Nup to maintain an unexpectedly high plasticity in its bound state. We propose that these exceptional physical characteristics enable a rapid and specific transport mechanism in the physiological context, a notion supported by single molecule in-cell assays on intact NPCs. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  12. Safety and Nonsafety Communications and Interactions in International Nuclear Power Plants

    International Nuclear Information System (INIS)

    Kisner, Roger A.; Mullens, James Allen; Wilson, Thomas L.; Wood, Richard Thomas; Korsah, Kofi; Qualls, A.L.; Muhlheim, Michael David; Holcomb, David Eugene; Loebl, Andy

    2007-01-01

    Current industry and NRC guidance documents such as IEEE 7-4.3.2, Reg. Guide 1.152, and IEEE 603 do not sufficiently define a level of detail for evaluating interdivisional communications independence. The NRC seeks to establish criteria for safety systems communications that can be uniformly applied in evaluation of a variety of safety system designs. This report focuses strictly on communication issues related to data sent between safety systems and between safety and nonsafety systems. Further, the report does not provide design guidance for communication systems nor present detailed failure modes and effects analysis (FMEA) results for existing designs. This letter report describes communications between safety and nonsafety systems in nuclear power plants outside the United States. A limited study of international nuclear power plants was conducted to ascertain important communication implementations that might have bearing on systems proposed for licensing in the United States. This report provides that following information: 1.communications types and structures used in a representative set of international nuclear power reactors, and 2.communications issues derived from standards and other source documents relevant to safety and nonsafety communications. Topics that are discussed include the following: communication among redundant safety divisions, communications between safety divisions and nonsafety systems, control of safety equipment from a nonsafety workstation, and connection of nonsafety programming, maintenance, and test equipment to redundant safety divisions during operation. Information for this report was obtained through publicly available sources such as published papers and presentations. No proprietary information is represented

  13. Secular variation of the amount of nuclear information and its interpretation by a media-public interaction model

    International Nuclear Information System (INIS)

    Ohnishi, Teruaki

    1998-01-01

    Time dependent characteristics of the amount of nuclear information fed by the Japanese press are explained by a nonlinear model with mutual interaction between the media and the public. In the secular variation of that amount since the early 1950s, there appears semicyclicly oscillating fine structure of that amount with a period of several months superposed on a background having a feature of slowly varying wave of information with a period of around ten years. A model is proposed such that an individual media determines its reportorial stance using the response of the public to the preceding information and the general tendency of the other media as measures of judgement. Since the structure of this model resembles to that of an evolving ecosystem, the paradigm shift in nuclear information can be interpreted by analogy with the succession of facies in an ecological system. Moreover, the slowly time-varying waves of information associated with the paradigm shift is found to be grasped as a resultant of prevalence phenomenon if the nuclear paradigm is regarded as a sort of prevalence. The oscillation of the amount of information in a short time scale, on the other hand, is found to appear as a result of the competition between the extent of reflection of the present amount of information to the next information and the extent of reflection of the reportorial state of the other media also to the next information under the existence of public response. Those characteristics regarding the amount of nuclear information are found to come out as necessary consequences of the society with mutual stimulation between the media and the public. (author)

  14. Screening length in dusty plasma crystals

    International Nuclear Information System (INIS)

    Nikolaev, V S; Timofeev, A V

    2016-01-01

    Particles interaction and value of the screening length in dusty plasma systems are of great interest in dusty plasma area. Three inter-particle potentials (Debye potential, Gurevich potential and interaction potential in the weakly collisional regime) are used to solve equilibrium equations for two dusty particles suspended in a parabolic trap. The inter-particle distance dependence on screening length, trap parameter and particle charge is obtained. The functional form of inter-particle distance dependence on ion temperature is investigated and compared with experimental data at 200-300 K in order to test used potentials applicability to dusty plasma systems at room temperatures. The preference is given to the Yukawa-type potential including effective values of particle charge and screening length. The estimated effective value of the screening length is 5-15 times larger than the Debye length. (paper)

  15. Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1.

    Science.gov (United States)

    Garapaty, Shivani; Mahajan, Muktar A; Samuels, Herbert H

    2008-03-14

    CCR4-NOT is an evolutionarily conserved, multicomponent complex known to be involved in transcription as well as mRNA degradation. Various subunits (e.g. CNOT1 and CNOT7/CAF1) have been reported to be involved in influencing nuclear hormone receptor activities. Here, we show that CCR4/CNOT6 and RCD1/CNOT9, members of the CCR4-NOT complex, potentiate nuclear receptor activity. RCD1 interacts in vivo and in vitro with NIF-1 (NRC-interacting factor), a previously characterized nuclear receptor cotransducer that activates nuclear receptors via its interaction with NRC. As with NIF-1, RCD1 and CCR4 do not directly associate with nuclear receptors; however, they enhance ligand-dependent transcriptional activation by nuclear hormone receptors. CCR4 mediates its effect through the ligand binding domain of nuclear receptors and small interference RNA-mediated silencing of endogenous CCR4 results in a marked decrease in nuclear receptor activation. Furthermore, knockdown of CCR4 results in an attenuated stimulation of RARalpha target genes (e.g. Sox9 and HoxA1) as shown by quantitative PCR assays. The silencing of endogenous NIF-1 also resulted in a comparable decrease in the RAR-mediated induction of both Sox9 and HoxA1. Furthermore, CCR4 associates in vivo with NIF-1. In addition, the CCR4-enhanced transcriptional activation by nuclear receptors is dependent on NIF-1. The small interference RNA-mediated knockdown of NIF-1 blocks the ligand-dependent potentiating effect of CCR4. Our results suggest that CCR4 plays a role in the regulation of certain endogenous RARalpha target genes and that RCD1 and CCR4 might mediate their function through their interaction with NIF-1.

  16. Development of an interactive model of the Laguna Verde nuclear power plant based on the RELAP/SCDAP code

    International Nuclear Information System (INIS)

    Salazar C, J.H.; Ramos P, J.C.; Salazar S, E.; Chavez M, C.

    2003-01-01

    The present work describes the development of an interactive model of the Nuclear power plant of Laguna Verde (CNLV) based on the RELAP/SCDAP nuclear code, and it incorporation to a classroom simulator. The functional prototype it allows to make evaluations for operational transients and postulates accidents, with capacitation purposes, training, analysis and design. It emphasizes on the methodology used to establish the inter activity. Such methodology, is based on a modular structure in the one that multiple processes can be executed in an independent way and where the generated information is stored in segments of shared memory (characteristic that allows the UNIX operating system) and sent to the different processes by means of communication routines developed in C programming language. The utility of the system is demonstrated by means of the use of interactive display graphics (mimic diagrams, pictorials and tendency graphics) for the simultaneous dynamic visualization of the variables more significant that involve to the pattern of a transitory event type (for example failure of the controller of feeding water in a BWR reactor). Near with the interactive module, it was developed a model of the reactor of the CNLV for the code of better estimation RELAP/SCDAP. Finally the evaluation of the model is described, where it is interpreted in general form the behavior of those main variables that describe the stationary state, corroborating that follow the same tendency that those reported in the FSAR (Final Safety Analysis Report) of the Laguna Verde plant. The obtained results allow to conclude that the made development was satisfactory and that it presents enormous advantages regarding the capacity and time of analysis when using tools of visualization in real time of execution. (Author)

  17. Baryon interactions from lattice QCD with physical quark masses - Nuclear forces and ΞΞ forces -

    Science.gov (United States)

    Doi, Takumi; Iritani, Takumi; Aoki, Sinya; Gongyo, Shinya; Hatsuda, Tetsuo; Ikeda, Yoichi; Inoue, Takashi; Ishii, Noriyoshi; Miyamoto, Takaya; Nemura, Hidekatsu; Sasaki, Kenji

    2018-03-01

    We present the latest lattice QCD results for baryon interactions obtained at nearly physical quark masses. Nf = 2 + 1 nonperturbatively O(a)-improved Wilson quark action with stout smearing and Iwasaki gauge action are employed on the lattice of (96a)4 ≃(8.1fm)4 with a-1 ≃2.3 GeV, where mπ ≃146 MeV and mK ≃525 MeV. In this report, we study the two-nucleon systems and two-Ξ systems in 1S0 channel and 3S1-3D1 coupled channel, and extract central and tensor interactions by the HAL QCD method. We also present the results for the NΩ interaction in 5S2 channel which is relevant to the NΩ pair-momentum correlation in heavy-ion collision experiments.

  18. General considerations on fire and explosions in a nuclear facility. Interaction with ventilation

    International Nuclear Information System (INIS)

    Savornin, J.

    1983-05-01

    After a brief survey of French regulations and documents used in defining fire and explosion precautions, a number of fires which have broken out in French nuclear power plants and their effects on ventilation are mentioned. Past or current tests and experiments in France are described, and the provisions made to create computer codes for refining fire safety analysis are presented. The regulations which have been established to reduce the risk of fire or explosion and to contain it without failure of the containment barrier provided by the ventilation system are then given [fr

  19. Implementation and verification of nuclear interactions in a Monte-Carlo code for the Procom-ProGam proton therapy planning system

    International Nuclear Information System (INIS)

    Kostyuchenko, V.I.; Makarova, A.S.; Ryazantsev, O.B.; Samarin, S.I.; Uglov, A.S.

    2013-01-01

    Proton interaction with an exposed object material needs to be modeled with account for three basic processes: electromagnetic stopping of protons in matter, multiple coulomb scattering and nuclear interactions. Just the last type of processes is the topic of this paper. Monte Carlo codes are often used to simulate high-energy particle interaction with matter. However, nuclear interaction models implemented in these codes are rather extensive and their use in treatment planning systems requires huge computational resources. We have selected the IThMC code for its ability to reproduce experiments which measure the distribution of the projected ranges of nuclear secondary particles generated by proton beams in a multi-layer Faraday cup. The multi-layer Faraday cup detectors measure charge rather than dose and allow distinguishing between electromagnetic and nuclear interactions. The event generator used in the IThMC code is faster, but less accurate than any other used in testing. Our model of nuclear reactions demonstrates quite good agreement with experiment in the context of their effect on the Bragg peak in therapeutic applications

  20. Telomere length and depression

    DEFF Research Database (Denmark)

    Wium-Andersen, Marie Kim; Ørsted, David Dynnes; Rode, Line

    2017-01-01

    BACKGROUND: Depression has been cross-sectionally associated with short telomeres as a measure of biological age. However, the direction and nature of the association is currently unclear. AIMS: We examined whether short telomere length is associated with depression cross-sectionally as well...... as prospectively and genetically. METHOD: Telomere length and three polymorphisms, TERT, TERC and OBFC1, were measured in 67 306 individuals aged 20-100 years from the Danish general population and associated with register-based attendance at hospital for depression and purchase of antidepressant medication....... RESULTS: Attendance at hospital for depression was associated with short telomere length cross-sectionally, but not prospectively. Further, purchase of antidepressant medication was not associated with short telomere length cross-sectionally or prospectively. Mean follow-up was 7.6 years (range 0...