Analysis of World Nuclear Market and Strategy of Korean NPP's Competitiveness Improvement for Exportation

International Nuclear Information System (INIS)

Choi, Jae Young; Jeong, Yong Hoon; Roh, Seungkook; Chang, Soon Heung

2016-01-01

China, India and USA (nuclear adopted countries) are planning tremendous number of NPPs to meet their increasing electricity demand and Saudi Arabia, Vietnam (nuclear adopting countries) are also planning to include nuclear power in their energy mix as a long-term plan. Korea has exported 4 units of APR1400 to the UAE in December, 2009. Korea became sixth NPP supplier country and our economic feasibility and safety features were started to evaluate worldwide. Nuclear industries became a new driver of Korea’s export and nuclear industries in Korea are now expecting another NPP export to Middle-eastern countries, including UAE and Saudi Arabia, based on the first-mover’s advantage at the UAE. In 2000s, five countries (Japan, USA, France, Russia and Korea), which are able to build NPP, focused on NPP export more than domestic construction. Global trend of world nuclear market changed rapidly, especially after NPP export to the UAE. By the global trend, hegemony of nuclear market migrated from supplier country to buyer country. Nuclear companies started cooperating rather than competing. Financing to developing countries become more important. In general, one of the considerable combinations is Korea-Japan-USA alliance. Korea is in charge of EPC, Japan supports financing and deficient technology (with USA partner), and Japan-USA handles fuel supply and back-end fuel cycle based on new agreed terms of ROK-US Nuclear Cooperation Agreement. This combination was judged to best way to collaborate with global companies. Paying attention to many delayed (or potentially delayed) constructions from Russia, intercepting the construction work will be available in case of contracted countries. Korea can emphasize the short construction time, high responsiveness and mild/equal diplomatic position to the target countries

Notice to exporters on products prohibited from export (nuclear material, equipment and large nuclear units)

International Nuclear Information System (INIS)

1988-01-01

In order to ensure that the policy to avoid the proliferation of nuclear weapons is complied with, the French Administration applies stricter controls over the export of certain sensitive products, materials and equipment. To this effect, lists of such products, materials and equipment are published in the form of Notices to exporters and periodically revised. This Notice repeals and replaces the previous Notice published in the Official Gazette of 21 January 1986. Annex I contains the list of materials whose export is subject to nuclear non-proliferation controls. Annex II lists the equipment whose export is subject to the same controls. Annex III includes the list of large nuclear units for which an application for prior approval of export must be submitted to the Administrations concerned. (NEA) [fr

Export markets for nuclear technology

International Nuclear Information System (INIS)

Huettl, A.J.

1985-01-01

By late 1984, nuclear power plants were in operation or under construction in 32 countries of the globe. An additional six countries had concrete plans for building nuclear power plants. Of these 38 countries, ten have shown that they posses the necessary know-how and the technical facilities to plan and build nuclear power plants practically on their own. Seven of these ten countries have already acted as exporters of nuclear power plants, albeit with very different degrees of market penetration. In addition, there have been a number of countries for quite some time whose industries have managed to manufacture many important nuclear power plant components. Their high level of technical development and the problems frequently encountered in export financing have made them very attractive partners of the true exporters of nuclear power plants. For the future, it must be expected that some of the countries which have so far limited their efforts to the construction of nuclear power plants at home will also develop into exporters of nuclear technology. The report contains a survey of the range of nuclear products available, a list of reactor vendors, reactor lines, and data on the economics of electricity generation in nuclear plants. It then goes on to offer detailed descriptions of the market and the demand situation. Interesting chapters are devoted to the selection criteria applied by importing countries, to financing problems, and to the influences exerted by the political environment. A realistic forecast is attempted in order to make a quantitative analysis of possible export contracts up until the year 2000. (orig.) [de

Nuclear export controls and nuclear safeguards

International Nuclear Information System (INIS)

Sevini, F.

2013-01-01

The export control of dual use goods has developed since the early seventies to counter nuclear proliferation. The paper provides an overview of dual-use export control issues also in relation with the Additional Protocol to the Comprehensive Safeguards Agreement, which requires States to provide declarations of the export of the controlled items listed in its Annex II, derived from the Nuclear Suppliers Group Trigger list. Recommendations for improvement are proposed. On the EU level, the paper summarises the framework set by the European Council Regulation 428/2009, requiring Member States to impose control on exports, brokering and transit of dual use goods. The Regulation includes the so-called 'EU dual-use control list' integrating the lists of dual-use items defined by the international regimes and requires also the control on intangible technology transfers as foreseen by U.N. Security Council Resolution 1540. ESARDA has recently launched a new sub-Working Group on export control, which raised large interest and may evolve to a full-fledged working group. Export control may provide an opportunity of technical collaboration between ESARDA and INMM. The paper is followed by the slides of the presentation. (author)

Nuclear Export of Messenger RNA

Directory of Open Access Journals (Sweden)

Jun Katahira

2015-03-01

Full Text Available Transport of messenger RNA (mRNA from the nucleus to the cytoplasm is an essential step of eukaryotic gene expression. In the cell nucleus, a precursor mRNA undergoes a series of processing steps, including capping at the 5' ends, splicing and cleavage/polyadenylation at the 3' ends. During this process, the mRNA associates with a wide variety of proteins, forming a messenger ribonucleoprotein (mRNP particle. Association with factors involved in nuclear export also occurs during transcription and processing, and thus nuclear export is fully integrated into mRNA maturation. The coupling between mRNA maturation and nuclear export is an important mechanism for providing only fully functional and competent mRNA to the cytoplasmic translational machinery, thereby ensuring accuracy and swiftness of gene expression. This review describes the molecular mechanism of nuclear mRNA export mediated by the principal transport factors, including Tap-p15 and the TREX complex.

Nuclear Export of Messenger RNA

Science.gov (United States)

Katahira, Jun

2015-01-01

Transport of messenger RNA (mRNA) from the nucleus to the cytoplasm is an essential step of eukaryotic gene expression. In the cell nucleus, a precursor mRNA undergoes a series of processing steps, including capping at the 5' ends, splicing and cleavage/polyadenylation at the 3' ends. During this process, the mRNA associates with a wide variety of proteins, forming a messenger ribonucleoprotein (mRNP) particle. Association with factors involved in nuclear export also occurs during transcription and processing, and thus nuclear export is fully integrated into mRNA maturation. The coupling between mRNA maturation and nuclear export is an important mechanism for providing only fully functional and competent mRNA to the cytoplasmic translational machinery, thereby ensuring accuracy and swiftness of gene expression. This review describes the molecular mechanism of nuclear mRNA export mediated by the principal transport factors, including Tap-p15 and the TREX complex. PMID:25836925

Nuclear exports. Parliamentary control and confidentiality

International Nuclear Information System (INIS)

Feldmann, Ulrike

2015-01-01

With its decision taken on 21. October 2014 (Az.: 2 BvE 5/11) the Federal Constitutional Court (BVerfG) decided during court proceedings between administrative bodies on the scope and limits of the parliamentary right of information. Even though the proceeding did not deal with nuclear exports but arm exports, foreign trade law, however, does not only designate an export licence obligation for military weapons but also for so called dual-use goods meaning goods, which can be used both for friendly as well as for military purposes. The export of these goods requires according to the so-called Dual-Use Regulation (EG) 428/2009 a licence. Annex I category 0 of the regulation (EG) 428/2009 lists a variety of nuclear materials, plants and equipment items for which this licence applies. In the same manner as arm exports, also exports of nuclear dual-use goods are being discussed in a special cabinet committee, the Federal Security Council (BSR), which shall coordinate cross-departmentally the German security and defence policy under consideration of economic interests and which categorises its results, according to the rules of procedure, as confidential. Also legally not regulated but common ''preliminary enquiries'' at the responsible Federal Ministry or rather Federal Office of Economics and Export Control by companies which plan an export and want to affirm the general approval for their export business prior to conclusion of contract take not only place for arm exports but also for nuclear dual-use goods. The decision by the Federal Constitutional Court can be applied to consultations about the authorisation of nuclear dual-use goods.

Prospects for Australian involvement in the nuclear fuel cycle

International Nuclear Information System (INIS)

Chandra, S.; Hallenstein, C.

1988-05-01

A review of recent overseas developments in the nuclear industry by The Northern Territory Department of Mines and Energy suggests that there are market prospects in all stages of the fuel cycle. Australia could secure those markets through aggressive marketing and competitive prices. This report gives a profile of the nuclear fuel cycle and nuclear fuel cycle technologies, and describes the prospects of Australian involvement in the nuclear fuel cycle. It concludes that the nuclear fuel cycle industry has the potential to earn around $10 billion per year in export income. It recommend that the Federal Government: (1) re-examines its position on the Slayter recommendation (1984) that Australia should develop new uranium mines and further stages of the nuclear fuel cycle, and (2) gives it's in-principle agreement to the Northern Territory to seek expressions of interest from the nuclear industry for the establishment of an integrated nuclear fuel cycle industry in the Northern Territory

The export of China nuclear power

International Nuclear Information System (INIS)

Zhang Jian

2012-01-01

The article first introduces the meaning of nuclear power export, and then analyses the advantages of China nuclear industry based on the status and development of this industry. At the same time. the collection of nuclear development for the next 30 years of several nations in south-east Asia, south Asia, Middle East, Africa and South America is compiled, which could be a valuable reference for foreseeing nuclear power export market. Finally, as the situation throughout the world is considered, some suggestions are made that what else could be done for future development and export. (author)

Analysis of World Nuclear Market and Strategy of Korean NPP's Competitiveness Improvement for Exportation

Energy Technology Data Exchange (ETDEWEB)

Choi, Jae Young; Jeong, Yong Hoon [KAIST, Daejeon (Korea, Republic of); Roh, Seungkook [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Chang, Soon Heung [Handong Global University, Pohang (Korea, Republic of)

2016-10-15

China, India and USA (nuclear adopted countries) are planning tremendous number of NPPs to meet their increasing electricity demand and Saudi Arabia, Vietnam (nuclear adopting countries) are also planning to include nuclear power in their energy mix as a long-term plan. Korea has exported 4 units of APR1400 to the UAE in December, 2009. Korea became sixth NPP supplier country and our economic feasibility and safety features were started to evaluate worldwide. Nuclear industries became a new driver of Korea’s export and nuclear industries in Korea are now expecting another NPP export to Middle-eastern countries, including UAE and Saudi Arabia, based on the first-mover’s advantage at the UAE. In 2000s, five countries (Japan, USA, France, Russia and Korea), which are able to build NPP, focused on NPP export more than domestic construction. Global trend of world nuclear market changed rapidly, especially after NPP export to the UAE. By the global trend, hegemony of nuclear market migrated from supplier country to buyer country. Nuclear companies started cooperating rather than competing. Financing to developing countries become more important. In general, one of the considerable combinations is Korea-Japan-USA alliance. Korea is in charge of EPC, Japan supports financing and deficient technology (with USA partner), and Japan-USA handles fuel supply and back-end fuel cycle based on new agreed terms of ROK-US Nuclear Cooperation Agreement. This combination was judged to best way to collaborate with global companies. Paying attention to many delayed (or potentially delayed) constructions from Russia, intercepting the construction work will be available in case of contracted countries. Korea can emphasize the short construction time, high responsiveness and mild/equal diplomatic position to the target countries.

Exporting nuclear engineering and the industry's viewpoint

International Nuclear Information System (INIS)

Barthelt, K.

1986-01-01

Nuclear energy offers all possibilities to reduce the energy problems in the world which arise with the world-wide increasing population and the energy demand connected with it. The Federal Republic of Germany lives on the exports of refined technical methods which also include nuclear engineering. The exports of nuclear engineering should lead to a technology transfer with guidance and training on an equal basis between the industrial and developing countries. The preconditions of exporting nuclear-technical systems are a well-functioning domestic market and a certain support by the government, especially with regard to giving guarantees for the special exports risks of these big projects. On the other hand, exports are also needed in order to be able to continue providing high-level technology for the domestic market. (UA) [de

Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export.

Science.gov (United States)

Behrens, Ryan T; Aligeti, Mounavya; Pocock, Ginger M; Higgins, Christina A; Sherer, Nathan M

2017-02-01

HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study the effects of modulating Rev NES identity, number, position, or strength on Rev subcellular trafficking, viral RNA nuclear export, and infectious virion production. We found that Rev activity was remarkably tolerant of diverse NES sequences, including supraphysiological NES (SNES) peptides that otherwise arrest CRM1 transport complexes at nuclear pores. Rev's ability to tolerate a SNES was both position and multimerization dependent, an observation consistent with a model wherein Rev self-association acts to transiently mask the NES peptide(s), thereby biasing Rev's trafficking into the nucleus. Combined imaging and functional assays also indicated that NES masking underpins Rev's well-known tendency to accumulate at the nucleolus, as well as Rev's capacity to activate optimal levels of late viral gene expression. We propose that Rev multimerization and NES masking regulates Rev's trafficking to and retention within the nucleus even prior to RNA binding. HIV-1 infects more than 34 million people worldwide causing >1 million deaths per year. Infectious virion production is activated by the essential viral Rev protein that mediates nuclear export of intron-bearing late-stage viral mRNAs. Rev's shuttling into and out of the nucleus is regulated by the antagonistic activities of both a peptide-encoded N-terminal nuclear localization signal and C-terminal nuclear export signal (NES). How Rev and related viral proteins balance strong import and export activities in order to achieve optimal levels of viral gene expression is incompletely understood. We provide evidence that multimerization provides a mechanism by which Rev transiently masks its NES peptide

Political implications of US nuclear-export-policy development

International Nuclear Information System (INIS)

Johnson-Freese, J.S.

1981-01-01

There has been a great deal of international debate regarding how effective strict export controls on nuclear-energy supplies are toward a non-proliferation goal. With the Carter Administration, the debate was heightened by a new, more-vigorous US nuclear-export policy, much of which was codified by the Nuclear Non-Proliferation Act of 1978 (NNPA). Because of the US position in both the international non-proliferation regime and nuclear export market, the NNPA has had far-reaching consequences. The thesis of this paper is that a nuclear-export policy that fails to consider its short-term ramifications, as the NNPA has been accused of, will be self-defeating. If the US wants a viable worldwide nuclear non-proliferation policy, it must first direct its efforts toward building a domestic non-proliferation consensus, and then worldwide, rather than first setting a highly controversial policy and expecting other nations to fall into line. This work provides a comprehensive case study of US nuclear-export policy between the years 1976 to 1980 in support of the thesis. Further, the behavior and impact of the interest groups which seem to shape US nuclear-export policies is examined, and recommendations made regarding the role of groups in nuclear policy-making and implementation. Finally, recommendations are made regarding non-proliferation policy for the future, as it relates to nuclear exports

A Study on Improvement of Export Control law's understanding for nuclear control items' exporters in Rep. of Korea

International Nuclear Information System (INIS)

Lim, Dong Hyuk; Choi, Sun Do; Yang, Seung Hyo

2011-01-01

According to export of UAE commercial reactor and JRTR(Jordan Research and Training Reactor) in 2009, Korea's international prestige has enhanced and it has been more important for researcher in charge of export control to understand and carry out duties on export control by obeying Nuclear Suppliers Group(NSG) Guidelines. Currently, the NSG tries to prevent the proliferation of nuclear weapons by harmonising export control systems of participating countries in relation to trade with nuclear commodities and nuclear-related dual-use materials, equipment, software and technology. In addition, through the implementation of two sets of Guidelines for nuclear exports and nuclear-related exports, the NSG aims to ensure that nuclear trade for peaceful purposes does not contribute to the proliferation of nuclear weapons or other nuclear explosive devices, and that international trade and cooperation in the nuclear field is not hindered unjustly in the process. However, there is still not a little confusion of export businesses owing to lack of understanding of nuclear items in Korea. Therefore, by correctly understanding export control systems, permits and licenses, ITT and persistingly communicating with export businesses, Researchers in charge of export control are able to eliminate confusion of production businesses regarding export and establish a export control culture

Export regulation

International Nuclear Information System (INIS)

Gates, D.J.

1978-01-01

Australia is a major uranium supplier. Uranium is exported under conditions laid down to avoid any nuclear proliferation. On 24 May 1977 the Prime Minister had stated the main elements of Australian policy: the strengthening of the system of international safeguards and the selection of importing countries. (Non-nuclear weapon states must be Contracting Parties to the NPT. Nuclear weapon states must undertake not to use Australian uranium for this purpose). Australia retains property of the uranium up to the UF 6 stage (uranium hexafluoride) in the fuel cycle; it reserves the right to stop any export if the importing country no longer complies with AIEA Safeguards. Any transfer to a third country, any irradiated fuel reprocessing, requires Australia's prior agreement. Finally, importing countries must satisfy physical protection conditions. (NEA) [fr

Storage of spent nuclear fuel: the problem of spent nuclear fuel in Bulgaria

Energy Technology Data Exchange (ETDEWEB)

Boyadzhiev, Z; Vapirev, E [Kombinat Atomna Energetika, Kozloduj (Bulgaria)

1996-12-31

A review of existing technologies for wet and dry storage of spent nuclear fuel (SNF) and the reprocessing policies is presented. The problem of SNF in Bulgaria is arising from nonobservance of the obligation to return SNF back to the former Soviet Union as agreed in the construction contract. In November 1994 approximately 1800 fuel assemblies have been stored in away-from-reactor (AFR) facility and another 1060 in at-reactor (AR) pools. The national policy is to export SNF out of the country. The AFR facility has a limited capacity and it is designed only for WWER-440 fuel although work is going on to extend it in order to store WWER-1000 SNF. 14 refs.

Storage of spent nuclear fuel: the problem of spent nuclear fuel in Bulgaria

International Nuclear Information System (INIS)

Boyadzhiev, Z.; Vapirev, E.

1995-01-01

A review of existing technologies for wet and dry storage of spent nuclear fuel (SNF) and the reprocessing policies is presented. The problem of SNF in Bulgaria is arising from nonobservance of the obligation to return SNF back to the former Soviet Union as agreed in the construction contract. In November 1994 approximately 1800 fuel assemblies have been stored in away-from-reactor (AFR) facility and another 1060 in at-reactor (AR) pools. The national policy is to export SNF out of the country. The AFR facility has a limited capacity and it is designed only for WWER-440 fuel although work is going on to extend it in order to store WWER-1000 SNF. 14 refs

Canada's nuclear export policy

Energy Technology Data Exchange (ETDEWEB)

Morrison, R W; Wonder, E F [Carleton Univ., Ottawa, Ontario (Canada)

1978-01-01

The factors influencing the evolution of Canada's nuclear export policy are examined. Initially, nuclear technology was exported to establish an industry in Canada and to share the technology with other countries. After 1974 an increasingly broad range of political and social factors were taken into account and safeguards became the dominant factor. The indirect impacts of the new policy fall into two groups. One consists of the effects of Canada's leadership in taking a tough stand on safeguards. The second group of effects involve the concern of other countries about access to secure energy supplies and advanced technology.

Canada's nuclear export policy

International Nuclear Information System (INIS)

Morrison, R.W.; Wonder, E.F.

1978-01-01

The factors influencing the evolution of Canada's nuclear export policy are examined. Initially, nuclear technology was exported to establish an industry in Canada and to share the technology with other countries. After 1974 an increasingly broad range of political and social factors were taken into account and safeguards became the dominant factor. The indirect impacts of the new policy fall into two groups. One consists of the effects of Canada's leadership in taking a tough stand on safeguards. The second group of effects involve the concern of other countries about access to secure energy supplies and advanced technology. (O.T.)

Nuclear export criteria and controls in the United States

International Nuclear Information System (INIS)

Shapar, H.K.

1979-01-01

The paper describes the export licensing procedure and the modifications made to it under the 1978 Nuclear Non-Proliferation Act (NNPA) to achieve greater control over exports of nuclear material and facilities. Export licences from the Nuclear Regulatory Commission are now required for certain items connected with nuclear plant construction and the procedure for obtaining the views of the Executive Branch have been formalised. The President is enabled to override the denial of an export licence by the NRC. Amongst the new criteria on the export licensing procedure added to the 1954 Atomic Energy Act, the NNPA provides that the IAEA Safeguards under the Non-Proliferation Treaty are applicable to exported nuclear material or facilities, together with adequate physical protection measures. (NEA) [fr

Nuclear exporters cartel

International Nuclear Information System (INIS)

Mandelbaum, M.

1977-01-01

Events that have transpired in the past few years that have caused renewed concern about the spread of nuclear weapons are reviewed. Many proposals have been made recently for keeping the bomb from spreading. The author feels that the most novel and intriguing of them is the one advanced by Senator Abraham Ribicoff and Steven J. Baker; in their proposal, the world market for nuclear reactors would be divided into precisely defined shares among the industrial nations that now manufacture them for export; each exporter would be guaranteed a certain number of sales annually; and each would pledge not to sell uranium enrichment or plutonium reprocessing technology, as Germany did to Brazil. This might not halt proliferation, but it would give the world a few more years to find a solution

Nuclear export of cutaneous HPV8 E7 oncoprotein is mediated by a leucine-rich nuclear export signal via a CRM1 pathway

Energy Technology Data Exchange (ETDEWEB)

Onder, Zeynep; Chang, Vivian; Moroianu, Junona, E-mail: moroianu@bc.edu

2015-01-01

We recently determined that the nuclear import of cutaneous beta genus HPV8 E7 oncoprotein it is mediated by its zinc-binding domain via direct hydrophobic interactions with the FG nucleoporins Nup62 and Nup153 (Onder and Moroianu, 2014). Here we investigated the nuclear export of HPV8 E7 oncoprotein using confocal microscopy after transfections of HeLa cells with EGFP–8cE7 and mutant plasmids and treatment with Ratjadone A nuclear export inhibitor. We determined that HPV8 E7 contains a leucine-rich nuclear export signal (NES), {sub 76}IRTFQELLF{sub 84}, within its zinc-binding domain that mediates its nuclear export via a CRM1 pathway. We found that HPV8 E7 interacts with CRM1 and that the hydrophobic amino acid residues I76, F79 and L82 of the NES are essential for this interaction and for nuclear export of HPV8 E7 oncoprotein. - Highlights: • HPV8 E7 has a leucine-rich NES within its zinc-binding domain that mediates its nuclear export. • CRM1 nuclear export receptor interacts with HPV8 E7 and mediates its export. • Identification of the critical hydrophobic amino acids of the NES of HPV8 E7.

Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export

Directory of Open Access Journals (Sweden)

Beatriz M. A. Fontoura

2013-07-01

Full Text Available Viruses possess many strategies to impair host cellular responses to infection. Nuclear export of host messenger RNAs (mRNA that encode antiviral factors is critical for antiviral protein production and control of viral infections. Several viruses have evolved sophisticated strategies to inhibit nuclear export of host mRNAs, including targeting mRNA export factors and nucleoporins to compromise their roles in nucleo-cytoplasmic trafficking of cellular mRNA. Here, we present a review of research focused on suppression of host mRNA nuclear export by viruses, including influenza A virus and vesicular stomatitis virus, and the impact of this viral suppression on host antiviral responses.

Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export

Science.gov (United States)

Kuss, Sharon K.; Mata, Miguel A.; Zhang, Liang; Fontoura, Beatriz M. A.

2013-01-01

Viruses possess many strategies to impair host cellular responses to infection. Nuclear export of host messenger RNAs (mRNA) that encode antiviral factors is critical for antiviral protein production and control of viral infections. Several viruses have evolved sophisticated strategies to inhibit nuclear export of host mRNAs, including targeting mRNA export factors and nucleoporins to compromise their roles in nucleo-cytoplasmic trafficking of cellular mRNA. Here, we present a review of research focused on suppression of host mRNA nuclear export by viruses, including influenza A virus and vesicular stomatitis virus, and the impact of this viral suppression on host antiviral responses. PMID:23872491

Nuclear power, nuclear exports and the non-proliferation of nuclear weapons

International Nuclear Information System (INIS)

Hildenbrand, G.

1977-01-01

Developed and developing countries alike unfortunately have no other options in replacing oil in electricity generation than to use coal or nuclear energy. As far as the supplier countries are concerned, there is no doubt that nobody is interested in adding to the proliferation of nuclear weapons. On the other hand, the future electricity requirement in the developing countries, especially the need for nuclear power plants, represents a considerable market in the medium and long term which the supplier countries cannot simply ignore because they must seek to secure their export shares in order to protect jobs at home. For the receiver countries it is a matter of principle to achieve the highest possible degree of independence in energy generation so as to be able to guarantee continuity of supply. The interest in building up national fuel cycle activities is also closely linked with the creation of jobs in the receiver countries and with the efforts of these countries to straighten out their balance of payments situation. (orig.) [de

Nuclear exports and international cooperation

International Nuclear Information System (INIS)

McCardle, J.J.

1981-06-01

Canada's nuclear export policy together with its non-proliferation and safeguards policy embrace both the country's desire to promote international cooperation in the peaceful uses of nuclear energy and its effort to minimize the risk of further proliferation of nuclear weapons. This policy reflects the belief that only if Canadian parliamentary and public opinion can be convinced that Canada's nuclear exports will not contribute to nuclear proliferation will the long-term health of the country's nuclear industry be assured. Canada requires a political commitment to non-proliferation from its nuclear partners, and looks to the IAEA to administer safeguards on nuclear material of Canadian origin to guarantee that commitment. Agreements reached with its nuclear partners are in accordance with provisions of the non-proliferation treaty and include a contingency provision for fall-back safeguards if the other state should withdraw from the NPT. Provision is made for mutual agreement on reprocessing and enrichment of nuclear material. Agreements have been reached with some twenty nuclear partners, and efforts are continuing to come to new international understanding on reprocessing, enrichment, and plutonium storage

Nuclear exportation and importation - the Brazilian situation

International Nuclear Information System (INIS)

Lavos Coimbra, G.

1986-01-01

The author proposes to set up a working group which should be responsible for the compilation of laws, procedures, and national policies for the nuclear importation and exportation in the supplying and receiving countries. Shared international views would simplify the flow of imports and exports between the countries. The author describes the different phases of exportation and importation of nuclear material are processed in her country, Brazil. (CW) [de

The politics of fading dreams: Britain and the nuclear export business

International Nuclear Information System (INIS)

Boardman, R.; Grieve, M.

1983-01-01

The subject is discussed as follows: introduction to a chapter focused on the politics of Britain's foreign nuclear trade; export goals and the nuclear programme (discussion of Magnox, AGR, SGHWR and PWR); the pursuit of exports; nuclear exports and proliferation (reprocessing; fast reactors; plutonium; INFCE); public opinion, nuclear power and exports (interest groups); conclusions (Britain's nuclear exports and non-proliferation). (U.K.)

Four decades of living with the genie: United States nuclear export policy

International Nuclear Information System (INIS)

Kramish, A.

1983-01-01

The subject is discussed as follows: general introduction (examples of complex nature of nuclear trade); non-proliferation policy - the beginnings (early US action to control dealings with other countries); the Nuclear Non-Proliferation Act of 1978 (formulation of US policy on nuclear trade; INFCE (International Nuclear Fuel Cycle Evaluation)); the Symington and Glenn Amendments (US legislation to control trade with other countries); the Export-Import Bank Act (US legislation for the same purpose as above); the Non-Proliferation Treaty; the Reagan Policy (US present policy to support IAEA safeguards and Non-Proliferation Treaty); future prospects. (U.K.)

The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA.

Science.gov (United States)

Booth, David S; Cheng, Yifan; Frankel, Alan D

2014-12-08

The HIV Rev protein routes viral RNAs containing the Rev Response Element (RRE) through the Crm1 nuclear export pathway to the cytoplasm where viral proteins are expressed and genomic RNA is delivered to assembling virions. The RRE assembles a Rev oligomer that displays nuclear export sequences (NESs) for recognition by the Crm1-Ran(GTP) nuclear receptor complex. Here we provide the first view of an assembled HIV-host nuclear export complex using single-particle electron microscopy. Unexpectedly, Crm1 forms a dimer with an extensive interface that enhances association with Rev-RRE and poises NES binding sites to interact with a Rev oligomer. The interface between Crm1 monomers explains differences between Crm1 orthologs that alter nuclear export and determine cellular tropism for viral replication. The arrangement of the export complex identifies a novel binding surface to possibly target an HIV inhibitor and may point to a broader role for Crm1 dimerization in regulating host gene expression.

Study on status of nuclear export/import implementation in KAERI

International Nuclear Information System (INIS)

Kim, H. J.; Lee, B. D.; Lee, S. H.; Park, H. J.; So, D. S.

2004-01-01

As Korea is the member of ZC(Zangger Committee) and NSG(Nuclear Suppliers Group), domestic legislation reflected their guideline of nuclear export. The paper investigate the status of implementation procedures of nuclear export and import in KAERI based on domestic and international law. In addition, the paper analyzes on problem of export/import implementation system and also extract the efficient implementation system of nuclear export and import

Approaches for Securing the Nuclear Fuel Cycle

International Nuclear Information System (INIS)

Kim, Jae San; Kim, Min Su; Jo, Seong Youn

2007-01-01

The greatest challenge to international nuclear nonproliferation regime is posed by nuclear energy's dual nature for both peaceful and military purposes. Uranium enrichment and spent nuclear fuel (SNF) reprocessing (sensitive nuclear technologies) are critical from the non-proliferation viewpoint because they may be used to produce weapons-grade nuclear materials. Therefore, since 1970s the world community started to develop further measures to curb the spread of sensitive nuclear technologies. The establishment of a Nuclear Suppliers Group (NSG) in 1975 was one such measure. The NSG united countries which voluntarily agreed to coordinate their legislation regarding export of nuclear materials, equipment and technologies to countries not possessing nuclear weapons. Alongside measures to limit the spread of sensitive nuclear technologies, multilateral approaches to the nuclear fuel cycle (NFC) started to be discussed. It's becoming increasingly important to link the objective need for an expanded use of nuclear energy with strengthening nuclear non-proliferation by preventing the spread of sensitive nuclear technologies and securing access for interested countries to NFC products and services

IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs.

Science.gov (United States)

Zhou, Hao; Bulek, Katarzyna; Li, Xiao; Herjan, Tomasz; Yu, Minjia; Qian, Wen; Wang, Han; Zhou, Gao; Chen, Xing; Yang, Hui; Hong, Lingzi; Zhao, Junjie; Qin, Luke; Fukuda, Koichi; Flotho, Annette; Gao, Ji; Dongre, Ashok; Carman, Julie A; Kang, Zizhen; Su, Bing; Kern, Timothy S; Smith, Jonathan D; Hamilton, Thomas A; Melchior, Frauke; Fox, Paul L; Li, Xiaoxia

2017-10-09

Expression of inflammatory genes is determined in part by post-transcriptional regulation of mRNA metabolism but how stimulus- and transcript-dependent nuclear export influence is poorly understood. Here, we report a novel pathway in which LPS/TLR4 engagement promotes nuclear localization of IRAK2 to facilitate nuclear export of a specific subset of inflammation-related mRNAs for translation in murine macrophages. IRAK2 kinase activity is required for LPS-induced RanBP2-mediated IRAK2 sumoylation and subsequent nuclear translocation. Array analysis showed that an SRSF1-binding motif is enriched in mRNAs dependent on IRAK2 for nuclear export. Nuclear IRAK2 phosphorylates SRSF1 to reduce its binding to target mRNAs, which promotes the RNA binding of the nuclear export adaptor ALYREF and nuclear export receptor Nxf1 loading for the export of the mRNAs. In summary, LPS activates a nuclear function of IRAK2 that facilitates the assembly of nuclear export machinery to export selected inflammatory mRNAs to the cytoplasm for translation.

US Nuclear Non-Proliferation Policy: impact on exports and nuclear industry could not be determined

International Nuclear Information System (INIS)

Staats, E.B.

1980-01-01

The Nuclear Non-Proliferation Act of 1978 established new measures to prevent the diversion to weapons use of peaceful nuclear exports. It also created a policy to confirm US reliability as a nuclear supplier. GAO did not identify any export sales lost as a result of the Act, but did find indications that nonprofileration policies can influence export sales. Based on avavailable data, GAO could not determine the impact of the Act on the competitiveness of US nuclear exports. However, US companies are at some disadvantage because importers perceive that implementation of the Act may result in delayed export licenses. The United States dominated the nuclear export market through the early 1970s. However, foreign competitors, some aided by US technology transfers, emerged to monopolize home markets and complete for third-country business. Further, the market has been depressed since 1974 and prospects for US nuclear power plant exports have dimmed greatly. However, US companies continue to view exports as important to sustain production capacity

Nuclear export controls - Closing the gaps

International Nuclear Information System (INIS)

Schmidt, Fritz W.

2005-01-01

Concerns over a nuclear 'black market' have focused international attention on the effectiveness of nuclear export controls. IAEA Director General Mohamed ElBaradei has stated that the emergence of a multinational illicit network demonstrated the inadequacy of the present export control system, that international cooperation on export controls lay on informal arrangements that were not only not binding but also limited in membership, and that export control information was not systematically shared with the IAEA. This criticism, often heard on the political level, does not really do justice to the work of export control groups. The emergence of a multinational illicit network does not necessarily prove failures in export control systems. Criminal activities, by definition, try to circumvent existing rules and regulations, or they exploit the absence of such rules on State level. To fight such individual cases is not so much a task of regular export control systems, whose function lies primarily in establishing standards and procedures for export controls on State level, but rather the task for intelligence services and their international cooperation. The basis of the export control regime is the Nuclear Non-Proliferation Treaty (NPT). Export controls can - and do - play an important role in fostering this universality goal by demanding the implementation of internationally agreed security standards in recipient countries before export licenses are granted. Drawn from the deliberations in the NPT conferences, the current standards to be demanded as conditions of supply are the following: Safeguards, Physical Protection, National export control provisions. According to the NPT system, export controls require IAEA verification in the recipient country. In addition, export controls enable States to provide information to the IAEA on exports and imports as required by the Additional Protocol. The 2005 NPT Review Conference will be an opportunity to review developments

A Study on Improvement of Export Control law's understanding for nuclear control items' exporters in Rep. of Korea

Energy Technology Data Exchange (ETDEWEB)

Lim, Dong Hyuk; Choi, Sun Do; Yang, Seung Hyo [Korea Institute of Nuclear Nonproliferation and Control, Daejeon (Korea, Republic of)

2011-10-15

According to export of UAE commercial reactor and JRTR(Jordan Research and Training Reactor) in 2009, Korea's international prestige has enhanced and it has been more important for researcher in charge of export control to understand and carry out duties on export control by obeying Nuclear Suppliers Group(NSG) Guidelines. Currently, the NSG tries to prevent the proliferation of nuclear weapons by harmonising export control systems of participating countries in relation to trade with nuclear commodities and nuclear-related dual-use materials, equipment, software and technology. In addition, through the implementation of two sets of Guidelines for nuclear exports and nuclear-related exports, the NSG aims to ensure that nuclear trade for peaceful purposes does not contribute to the proliferation of nuclear weapons or other nuclear explosive devices, and that international trade and cooperation in the nuclear field is not hindered unjustly in the process. However, there is still not a little confusion of export businesses owing to lack of understanding of nuclear items in Korea. Therefore, by correctly understanding export control systems, permits and licenses, ITT and persistingly communicating with export businesses, Researchers in charge of export control are able to eliminate confusion of production businesses regarding export and establish a export control culture

Nuclear export of cutaneous HPV8 E7 oncoprotein is mediated by a leucine-rich nuclear export signal via a CRM1 pathway.

Science.gov (United States)

Onder, Zeynep; Chang, Vivian; Moroianu, Junona

2015-01-01

We recently determined that the nuclear import of cutaneous beta genus HPV8 E7 oncoprotein it is mediated by its zinc-binding domain via direct hydrophobic interactions with the FG nucleoporins Nup62 and Nup153 (Onder and Moroianu, 2014). Here we investigated the nuclear export of HPV8 E7 oncoprotein using confocal microscopy after transfections of HeLa cells with EGFP-8cE7 and mutant plasmids and treatment with Ratjadone A nuclear export inhibitor. We determined that HPV8 E7 contains a leucine-rich nuclear export signal (NES), 76IRTFQELLF84, within its zinc-binding domain that mediates its nuclear export via a CRM1 pathway. We found that HPV8 E7 interacts with CRM1 and that the hydrophobic amino acid residues I76, F79 and L82 of the NES are essential for this interaction and for nuclear export of HPV8 E7 oncoprotein. Copyright © 2014 Elsevier Inc. All rights reserved.

Inhibition of CRM1-mediated nuclear export of influenza A nucleoprotein and nuclear export protein as a novel target for antiviral drug development.

Science.gov (United States)

Chutiwitoonchai, Nopporn; Mano, Takafumi; Kakisaka, Michinori; Sato, Hirotaka; Kondoh, Yasumitsu; Osada, Hiroyuki; Kotani, Osamu; Yokoyama, Masaru; Sato, Hironori; Aida, Yoko

2017-07-01

An anti-influenza compound, DP2392-E10 based on inhibition of the nuclear export function of the viral nucleoprotein-nuclear export signal 3 (NP-NES3) domain was successfully identified by our previous high-throughput screening system. Here, we demonstrated that DP2392-E10 exerts its antiviral effect by inhibiting replication of a broad range of influenza A subtypes. In regard to the molecular mechanism, we revealed that DP2392-E10 inhibits nuclear export of both viral NP and nuclear export protein (NEP). More specifically, in vitro pull-down assays revealed that DP2392-E10 directly binds cellular CRM1, which mediates nuclear export of NP and NEP. In silico docking suggested that DP2392-E10 binds at a region close to the HEAT9 and HEAT10 domains of CRM1. Together, these results indicate that the CRM1-mediated nuclear export function of influenza virus represents a new potential target for antiviral drug development, and also provide a core structure for a novel class of inhibitors that target this function. Copyright © 2017 Elsevier Inc. All rights reserved.

Inhibition of CRM1-mediated nuclear export of influenza A nucleoprotein and nuclear export protein as a novel target for antiviral drug development

Energy Technology Data Exchange (ETDEWEB)

Chutiwitoonchai, Nopporn; Mano, Takafumi; Kakisaka, Michinori; Sato, Hirotaka [Viral Infectious Disease Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Kondoh, Yasumitsu; Osada, Hiroyuki [Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Kotani, Osamu; Yokoyama, Masaru; Sato, Hironori [Laboratory of Viral Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011 (Japan); Aida, Yoko, E-mail: aida@riken.jp [Viral Infectious Disease Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)

2017-07-15

An anti-influenza compound, DP2392-E10 based on inhibition of the nuclear export function of the viral nucleoprotein-nuclear export signal 3 (NP-NES3) domain was successfully identified by our previous high-throughput screening system. Here, we demonstrated that DP2392-E10 exerts its antiviral effect by inhibiting replication of a broad range of influenza A subtypes. In regard to the molecular mechanism, we revealed that DP2392-E10 inhibits nuclear export of both viral NP and nuclear export protein (NEP). More specifically, in vitro pull-down assays revealed that DP2392-E10 directly binds cellular CRM1, which mediates nuclear export of NP and NEP. In silico docking suggested that DP2392-E10 binds at a region close to the HEAT9 and HEAT10 domains of CRM1. Together, these results indicate that the CRM1-mediated nuclear export function of influenza virus represents a new potential target for antiviral drug development, and also provide a core structure for a novel class of inhibitors that target this function. - Highlights: •DP2392-E10 inhibits replication of a broad range of influenza A subtypes. •DP2392-E10 inhibits nuclear exports of NP and NEP via their NP-NES3 and NEP-NES2 domains, respectively. •DP2392-E10 is predicted to directly bind CRM1 in the region near the HEAT9 and HEAT10 repeats.

Inhibition of CRM1-mediated nuclear export of influenza A nucleoprotein and nuclear export protein as a novel target for antiviral drug development

International Nuclear Information System (INIS)

Chutiwitoonchai, Nopporn; Mano, Takafumi; Kakisaka, Michinori; Sato, Hirotaka; Kondoh, Yasumitsu; Osada, Hiroyuki; Kotani, Osamu; Yokoyama, Masaru; Sato, Hironori; Aida, Yoko

2017-01-01

An anti-influenza compound, DP2392-E10 based on inhibition of the nuclear export function of the viral nucleoprotein-nuclear export signal 3 (NP-NES3) domain was successfully identified by our previous high-throughput screening system. Here, we demonstrated that DP2392-E10 exerts its antiviral effect by inhibiting replication of a broad range of influenza A subtypes. In regard to the molecular mechanism, we revealed that DP2392-E10 inhibits nuclear export of both viral NP and nuclear export protein (NEP). More specifically, in vitro pull-down assays revealed that DP2392-E10 directly binds cellular CRM1, which mediates nuclear export of NP and NEP. In silico docking suggested that DP2392-E10 binds at a region close to the HEAT9 and HEAT10 domains of CRM1. Together, these results indicate that the CRM1-mediated nuclear export function of influenza virus represents a new potential target for antiviral drug development, and also provide a core structure for a novel class of inhibitors that target this function. - Highlights: •DP2392-E10 inhibits replication of a broad range of influenza A subtypes. •DP2392-E10 inhibits nuclear exports of NP and NEP via their NP-NES3 and NEP-NES2 domains, respectively. •DP2392-E10 is predicted to directly bind CRM1 in the region near the HEAT9 and HEAT10 repeats.

International Nuclear Fuel Cycle Evaluation

International Nuclear Information System (INIS)

Carnesale, A.

1980-01-01

As nuclear power expands globally, so too expands the capability for producing nuclear weapons. The International Nuclear Fuel Cycle Evaluation (INFCE) was organized in 1977 for the purpose of exploring two areas: (1) ways in which nuclear energy can be made available to help meet world energy needs, and (2) means by which the attendant risk of weapons proliferation can be held to a minimum. INFCE is designed for technical and analytical study rather than negotiation. Its organizational structure and issues under consideration are discussed. Some even broader issues that emerge from consideration of the relationships between the peaceful and military use of nuclear energy are also discussed. These are different notions of the meaning of nuclear proliferation, nuclear export policy, the need of a nuclear policy to be both a domestic as well as a foreign one, and political-military measures that can help reduce incentives of countries to acquire nuclear weapons of their own

The nuclear importation and exportation - The Brazilian situation

International Nuclear Information System (INIS)

Coimbra, G.L.

1985-01-01

The panorama of Brazilian economy emphasizing the measurements adopted by Brazilian government referring to importation and exportation policy is presented. The Brazilian Nuclear Program knows the nuclear trade gives good economic perspective. In the context of importation and exportation policy the laws concerned to nuclear trade transactions, taxes, national organizations responsible by the external trade policy and their attributions are presented. (M.C.K.) [pt

Equipment system for advanced nuclear fuel development

International Nuclear Information System (INIS)

Kwon, Hyuk Il; Ji, C. G.; Bae, S. O.

2002-11-01

The purpose of the settlement of equipment system for nuclear Fuel Technology Development Facility(FTDF) is to build a seismic designed facility that can accommodate handling of nuclear materials including <20% enriched Uranium and produce HANARO fuel commercially, and also to establish the advanced common research equipment essential for the research on advanced fuel development. For this purpose, this research works were performed for the settlement of radiation protection system and facility special equipment for the FTDF, and the advanced common research equipment for the fuel fabrication and research. As a result, 11 kinds of radiation protection systems such as criticality detection and alarm system, 5 kinds of facility special equipment such as environmental pollution protection system and 5 kinds of common research equipment such as electron-beam welding machine were established. By the settlement of exclusive domestic facility for the research of advanced fuel, the fabrication and supply of HANARO fuel is possible and also can export KAERI-invented centrifugal dispersion fuel materials and its technology to the nations having research reactors in operation. For the future, the utilization of the facility will be expanded to universities, industries and other research institutes

Exporting nuclear engineering and the government's viewpoint

International Nuclear Information System (INIS)

Schill, H.

1986-01-01

The reasons for the government's positive attitude to nuclear engineering exports are explained, especially with regard to them being a compensation of the decreasing domestic demand. The federal government considers such exports to be necessary and correct for economical and energy-political reasons. Their contribution reaches from accompanying measures to the provision of state guarantees of export financing activities. (UA) [de

Analysis and prediction of leucine-rich nuclear export signals

DEFF Research Database (Denmark)

La Cour, T.; Kiemer, Lars; Mølgaard, Anne

2004-01-01

We present a thorough analysis of nuclear export signals and a prediction server, which we have made publicly available. The machine learning prediction method is a significant improvement over the generally used consensus patterns. Nuclear export signals (NESs) are extremely important regulators...... this analysis is that the most important properties of NESs are accessibility and flexibility allowing relevant proteins to interact with the signal. Furthermore, we show that not only the known hydrophobic residues are important in defining a nuclear export signals. We employ both neural networks and hidden...

Information Interaction with IAEA on Nuclear Import and Export

International Nuclear Information System (INIS)

Osokina, A.; Snytnikov, A.

2015-01-01

This paper considers organizational aspects of nuclear import and export interaction between the Russian Federation and the Agency. Requirements of nuclear import and export in Russia, information submission procedure and forms are determined in RF Government Regulation No 973 from December 15th 2000. Particularly, according to these requirements Russian licenced organizations implementing nuclear import and export submit reports about appointed transfers to State Corporation 'Rosatom'. Regulations of State Corporation 'Rosatom' entrusted gathering and processing of reporting information and interaction with IAEA to FSUE 'SCC of Rosatom'. Regulations of reporting information interaction were developed by SCC and approved by State Corporation 'Rosatom'. Russian organizations send notifications to SCC using regulation electron or paper forms. Regulations determine information security measures in reporting process. Automated nuclear import and export accounting system developed by SCC provides data entering, keeping and processing, enables to choose and submit requested information in different formats. This system is integrated with State Nuclear Material Control and Accounting System. Also submitted information is regularly compared with customs declarations data to improve reliability and consistency of information. Generalized nuclear import and export data is using by Departments of State Corporation 'Rosatom' and transmitting to Federal Environmental, Industrial and Nuclear Supervision Service of Russia in agreed forms. Summary information about international nuclear transfers is sending to IAEA according to INFCIRC/207. Reporting information is coordinating. Messaging with IAEA is realized by email using enciphering program. (author)

Export of nuclear equipment and materials and the non-proliferation of nuclear weapons

International Nuclear Information System (INIS)

Courteix, Simone.

1977-01-01

The problem of the non-proliferation of nuclear weapons is one of great concern today despite the entry into force in the early '70s of the NPT. To master civilian nuclear technology implies the ability to develop nuclear explosive devices; therefore in recent years contacts have strengthened between countries exporting nuclear equipment, specially in the frame of the 'London Club' so as to ensure that their exports will not result in disseminating nuclear weapons. (NEA) [fr

Assessing mRNA nuclear export in mammalian cells by microinjection.

Science.gov (United States)

Lee, Eliza S; Palazzo, Alexander F

2017-08-15

The nuclear export of mRNAs is an important yet little understood part of eukaryotic gene expression. One of the easiest methods for monitoring mRNA export in mammalian tissue culture cells is through the microinjection of DNA plasmids into the nucleus and monitoring the distribution of the transcribed product over time. Here we describe how to setup a microscope equipped with a micromanipulator used in cell microinjections, and we explain how to perform a nuclear mRNA export assay and obtain the nuclear export rate for any given mRNA. Copyright © 2017 Elsevier Inc. All rights reserved.

Oil exporting countries need nuclear power

International Nuclear Information System (INIS)

Stauffer, T.R.

1982-01-01

The economic rationale for nuclear power in the oil exporting countries is analysed, with the collateral objective of defining the size of the potential market in terms of the exporting countries' economic opportunities and energy needs. The need for appropriate new institutions for licensing reactors, training personnel, and starting up plants follows directly from the size of the market and the economic incentives for the oil exporters to husband gas and oil. Gas and oil resources of the Middle Eastern countries are discussed, and future electricity needs estimated. (author)

Nuclear fuels

International Nuclear Information System (INIS)

Gangwani, Saloni; Chakrabortty, Sumita

2011-01-01

Nuclear fuel is a material that can be consumed to derive nuclear energy, by analogy to chemical fuel that is burned for energy. Nuclear fuels are the most dense sources of energy available. Nuclear fuel in a nuclear fuel cycle can refer to the fuel itself, or to physical objects (for example bundles composed of fuel rods) composed of the fuel material, mixed with structural, neutron moderating, or neutron reflecting materials. Long-lived radioactive waste from the back end of the fuel cycle is especially relevant when designing a complete waste management plan for SNF. When looking at long-term radioactive decay, the actinides in the SNF have a significant influence due to their characteristically long half-lives. Depending on what a nuclear reactor is fueled with, the actinide composition in the SNF will be different. The following paper will also include the uses. advancements, advantages, disadvantages, various processes and behavior of nuclear fuels

Introduction to Technology Export License of Nuclear Facility

Energy Technology Data Exchange (ETDEWEB)

Seo, Hana; Lee, Chansuh; Shin, Donghoon [Korea Institute of Nuclear Nonproliferation and Control, Daejeon (Korea, Republic of)

2014-05-15

In this regime, the Nuclear Safety and Security Commission (NSSC) has authority on final decision making. And the Korea Institute of Nuclear nonproliferation and Control (KINAC) has missions to review the classification and export licensing technically. In principle, classification and export licensing are applied and reviewed individually. However, the number of application for classification and licensing has increased geometrically in the last three years. This is largely a due to the contract that the Republic of Korea (ROK) has finalized to build the UAE Barakah Nuclear Power Plant (BNPP) and Jordan Research and Training Reactor (JRTR). This circumstance brought an administrative burden for the government and related institutes as well as stakeholders. This article introduces the law related to the 'Technology Export License of Nuclear Facility' which was developed and legislated to improve the efficiency and effectiveness of commodities classification and export licensing. This system could significantly reduce the licensing burden for transferring the technologies. However, the classification and license on this system are still requested when transferring the goods. Therefore, KINAC will continue to figure out the needs for the stakeholders and keep searching for solutions to problems inherent in the industry.

Introduction to Technology Export License of Nuclear Facility

International Nuclear Information System (INIS)

Seo, Hana; Lee, Chansuh; Shin, Donghoon

2014-01-01

In this regime, the Nuclear Safety and Security Commission (NSSC) has authority on final decision making. And the Korea Institute of Nuclear nonproliferation and Control (KINAC) has missions to review the classification and export licensing technically. In principle, classification and export licensing are applied and reviewed individually. However, the number of application for classification and licensing has increased geometrically in the last three years. This is largely a due to the contract that the Republic of Korea (ROK) has finalized to build the UAE Barakah Nuclear Power Plant (BNPP) and Jordan Research and Training Reactor (JRTR). This circumstance brought an administrative burden for the government and related institutes as well as stakeholders. This article introduces the law related to the 'Technology Export License of Nuclear Facility' which was developed and legislated to improve the efficiency and effectiveness of commodities classification and export licensing. This system could significantly reduce the licensing burden for transferring the technologies. However, the classification and license on this system are still requested when transferring the goods. Therefore, KINAC will continue to figure out the needs for the stakeholders and keep searching for solutions to problems inherent in the industry

Implementation of the Nuclear Export Control at KAERI

International Nuclear Information System (INIS)

Kim, Hyun-Jo; Lee, Byung-Doo; Lee, Sung-Ho

2006-01-01

Korea has joined multilateral export control regimes which include Wassenaar Arrangement(WA), Nuclear Suppliers Group(NSG), Missile Technology Control Regime(MTCR) and Australian Group(AG), and their guideline and control lists are reflected in domestic legislation. Also, Catch-all control entered into force on 1 January 2003 in Korea. The frequency of the exports of product as a result of R and D and cooperation with other countries has been increased at Korea Atomic Energy Research Institute (KAERI). Therefore, this report describes the implementation status of a nuclear export control at KAERI and points out the practical issues

Korea nuclear exports: Why did the Koreans win the UAE tender? Will Korea achieve its goal of exporting 80 nuclear reactors by 2030?

International Nuclear Information System (INIS)

Berthelemy, Michel; Leveque, Francois

2011-01-01

The success of Korea in winning, in December 2009, a USD 18.6 billion nuclear tender in the United Arab Emirates (UAE) has led to a growing interest in the organization and strengths of the Korean nuclear industry. In this paper, we present the main economic and political factors that explain the success of the Korean consortium. In particular, thanks to an active national program of Nuclear Power Plant (NPP) construction, Korea has developed distinct competitive advantages in terms of low cost, high credibility and high performance. At the same time, due to the important barriers to enter into the nuclear export market in the UAE, Korea has had to sacrifice its profit margin and has benefited from a strong political support from its government through export financing. More importantly, Korea's success is also due to its alliance with Westinghouse and the support of the US diplomacy. Subsequently, we show that while Korea has recently experienced setbacks in nuclear tenders, it will most certainly try to win in the short run a second nuclear tender with another aggressive price. In the longer run, Korea could take a growing share of the international market for NPPs. However, the extent to which Korea can achieve its long term export target will depend upon its capacity to finance nuclear export through export credits and upon the development of its alliance with Westinghouse. It is important to note that this paper was written before the Fukushima nuclear disaster. The scale of the human and environmental consequences of this accident are still unknown, and will undoubtedly have short and long term consequences on nuclear safety requirements and public attitude toward nuclear energy, which will most certainly impact the outlooks for nuclear new-builds. (authors)

Summary case for mining and export of Australia's uranium deposits for peaceful uses in generation of electricity

International Nuclear Information System (INIS)

1984-04-01

Arguments in support of the mining and export of Australian uranium are presented. They concern economic development and export income; environmental advantages over fossil fuels; the existence of appropriate safety standards and procedures and of effective waste management procedures; and the potential, as a uranium exporter, to influence international discussions relating to safeguards. Chapters cover world statistics on nuclear power, sources of uranium, fuel cycle stages and related safety issues, environmental aspects of the fuel cycle, safeguards, high level waste management, the connection between nuclear power and nuclear weapons, and economic benefits to Australia

An evaluation of Kazakhstan nuclear export control system

International Nuclear Information System (INIS)

Yeligbayeva, G.; Masenov, Ch.

2002-01-01

A system to control the export nuclear materials and technologies is a natural part of creating a self-sustaining government. The government of Kazakhstan has made a great deal of progress in building such a system. Control of export and import of nuclear materials and technologies and dual-use materials, related to nuclear activity, became one of the important part of mechanism of Non-Proliferation conditions realization in Kazakhstan. The system of export control has developed well over the 10 years. Kazakhstan is in the midst of a long process of building a functional export control system consistent with World standards. The state system of export control currently exists in Kazakhstan on the legislative base, and is based on efficient cooperation of the KAEC with a number of competent state bodies (Ministry of Economy, Ministry of Foreign Affairs, State Customs Committee) each of them has its own specific functions, duties and rights. The export is carried out using licenses, issued by the Ministry of Economy of the RK, according to applications of certain standard which are previously agreed with the KAEC under decision of the RK Government. The KAEC, acting on the base of export control principles and observance of international obligations on non-proliferation matter, makes decisions, only after thorough evaluation of ways of export and reliability of an end-user of the commodity, to agree the application for a license. The most fully developed aspect is the licensing process. General politics of export regulation in Kazakhstan are based on normative acts and rules, which are wholly appropriate (complementary) to the managing principles of nuclear export. There exists a full legal basis for the licensing system. But the process is going, some provisions is changing: in 2000 Kazakhstan corrected the export control law and approved the national control list very similar with EU control list, in 2002 the rules of the process of licensing the export and import

Changing the Rules on Fuel Export at Sellafield's First Fuel Storage Pond - 12065

Energy Technology Data Exchange (ETDEWEB)

Carlisle, Derek [Sellafield Ltd, Sellafield, Cumbria (United Kingdom)

2012-07-01

The Pile Fuel Storage Pond (PFSP) was built in 1949/50 to receive, store and de-can fuel and isotopes from the Windscale Piles. Following closure of the Piles in 1957, plant operations were scaled down until fuel processing eventually ceased in 1962. The facility has held an inventory of metal fuel both from the Piles and from other programmes since that time. The pond is currently undergoing remediation and removal of the fuel is a key step in that process, unfortunately the fuel export infrastructure on the plant is no longer functional and due to the size and limited lifting capability, the plant is not compatible with today's large volume heavy export flasks. The baseline scheme for the plant is to package fuel into a small capacity flask and transfer it to another facility for treatment and repackaging into a flask compatible with other facilities on site. Due to programme priorities the repackaging facility is not available to do this work for several years causing a delay to the work. In an effort accelerate the programme the Metal Fuel Pilot Project (MFPP) was initiated to challenge the norms for fuel transfer and develop a new methodology for transferring the fuel. In developing a transfer scheme the team had to overcome challenges associated with unknown fuel condition, transfers outside of bulk containment, pyro-phoricity and oxidisation hazards as well as developing remote control and recovery systems for equipment not designed for this purpose. A combination of novel engineering and enhanced operational controls were developed which resulted in the successful export of the first fuel to leave the Pile Fuel Storage Pond in over 40 years. The learning from the pilot project is now being considered by the main project team to see how the new methodology can be applied to the full inventory of the pond. (author)

Quality control of nuclear fuel plates using digital image processing techniques

International Nuclear Information System (INIS)

Salinas, Renato; Radd, Ulrich; Coronado, Harold; Olivares, Luis

2003-01-01

The Chilean Atomic Energy Commission (CCHEN) has developed the technology requires to manufacture low enriched uranium-235 nuclear fuel elements used in non-power reactor applications and in research. These fuel plates are assembled in two nuclear facilities located at La Reina (RECH-1) and Lo Aguirre where the present work was developed. Furthermore since high quality standards have been met, these facilities are able to export these nuclear fuel plates to foreign countries. Each MTR fuel elements consists of 16 low enriched uranium silicide (U 3 Si 2 ) fuel plates. A stringent quality assurance program requires among others, homogeneity measurements of uranium surface density values of these fuel plates, which are traditionally accomplished with optical densitometry methods. We have implemented and alternative technique which uses computer vision to determine uranium surface density values in these fuel plates. Both techniques are compared. Advantages of machine vision methods include considerable time saving and a complete quantitative evaluation of uranium densities as compared to the sparse technique involved in the optical densitometry method (Au)

Development of a nuclear fuel cycle transparency framework

International Nuclear Information System (INIS)

Love, Tracia L.

2005-01-01

Nuclear fuel cycle transparency can be defined as a confidence building approach among political entities to ensure civilian nuclear facilities are not being used for the development of nuclear weapons. Transparency concepts facilitate the transfer of nuclear technology, as the current international political climate indicates a need for increased methods of assuring non-proliferation. This research develops a system which will augment current non-proliferation assessment activities undertaken by U.S. and international regulatory agencies. It will support the export of nuclear technologies, as well as the design and construction of Gen. IV energy systems. Additionally, the framework developed by this research will provide feedback to cooperating parties, thus ensuring full transparency of a nuclear fuel cycle. As fuel handling activities become increasingly automated, proliferation or diversion potential of nuclear material still needs to be assessed. However, with increased automation, there exists a vast amount of process data to be monitored. By designing a system that monitors process data continuously, and compares this data to declared process information and plant designs, a faster and more efficient assessment of proliferation risk can be made. Figure 1 provides an illustration of the transparency framework that has been developed. As shown in the figure, real-time process data is collected at the fuel cycle facility; a reactor, a fabrication plant, or a recycle facility, etc. Data is sent to the monitoring organization and is assessed for proliferation risk. Analysis and recommendations are made to cooperating parties, and feedback is provided to the facility. The analysis of proliferation risk is based on the following factors: (1) Material attractiveness: the quantification of factors relevant to the proliferation risk of a certain material (e.g., highly enriched Pu-239 is more attractive than that of lower enrichment) (2) The static (baseline) risk: the

Exporting apocalypse: CANDU reactors and nuclear proliferation

International Nuclear Information System (INIS)

McKay, Paul.

The author believes that the peaceful use of nuclear technology leads inevitably to the production of nuclear weapons, and that CANDU reactors are being bought by countries that are likely to build bombs. He states that exports of reactors and nuclear materials cannot be defended and must be stopped

Legal problems concerning the export of nuclear power plants

International Nuclear Information System (INIS)

Pierer, Heinrich von.

1977-01-01

The legal problems raised by the export of nuclear power plants may be divided into three main categories: nuclear operator's liability for nuclear damage, the consequences for the supplier of the licensing requirements in the national laws of the buyer country and finally, the constraints of applying non-proliferation safeguards on export of nuclear equipment. As regards the third party liability regime in particular, the difficulties lie essentially in the insufficiency of the definition of the nuclear operator and the lack of harmonization in, or even the absence of national laws in this field. (NEA) [fr

Nuclear fuel licensing procedures in Bulgaria

Energy Technology Data Exchange (ETDEWEB)

Harizanov, Y [Komitet za Mirno Izpolzuvane na Atomnata Energiya, Sofia (Bulgaria). Komysia za Biologichni i Selskostopanski Nauki

1994-12-31

A brief description of the structure and role of the Committee on the Use of Atomic Energy for Peaceful Purposes (BG) as a main governmental institution responsible for safety atomic energy management is presented. The main documentation and licensing procedures adopted for import, export, operation, storage and transportation of nuclear material including nuclear fuel for NPP are outlined. The corresponding institutions are facing now the urgent need for changing some regulations to meet the requirements of the international treaties and conventions recently signed by Bulgarian authorities. A new version of Atomic Law disposed at the Parliament for adoption is essential for updating the management of NPP in Bulgaria where four WWER-440 and two WWER-1000 are under operation.

Analysis of nuclear export control system and implementing international nonproliferation regime in China

International Nuclear Information System (INIS)

Kim, J. S.; Lee, J. S.; Ahn, J. S.; Kim, B. G.; Min, K. S.

2000-01-01

China's exporting behaviour of nuclear items had been disconnected from the international non-proliferation regime such as IAEA safeguards and export control related with peaceful use of nuclear energy since 1970s. Especially, China had been one of principle suppliers of nuclear facility and technologies to Pakistan and Iran which had developed nuclear weapon programs. On the other hand, according to the rapid growth of economic scale after China began to open to the world, an active program for nuclear power plant as an electricity source had established. This means that China have surfaced as a big market to Korean nuclear industries. Regarding this, the paper dealt with the nuclear export control matters, i.e. the history of nuclear export control system and analyzed on background of enforcement of U.S.-China Nuclear Cooperation Agreement that had been apolitical issue between U.S. and China. Prospects toward conforming its nuclear export policies, laws and regulations to international standards also analyzed in results

Overview of nuclear export policies of major foreign supplier nations

International Nuclear Information System (INIS)

1977-01-01

The United States faces increased competition from foreign nuclear suppliers, including West Germany, France, the United Kingdom, Canada, and possibly, in the near future, Japan. This general overview shows the differences and similarities in foreign nuclear supplier export requirements. It is based on summaries furnished by the Department of State covering the nuclear export policies and procedures of the major foreign supplier nations

Nuclear Non-Proliferation and Export Control in the Republic of Croatia

International Nuclear Information System (INIS)

Valcic, I.; Prah, M.; Mikec, N.

2006-01-01

In accordance with its internationally accepted obligations, the Republic of Croatia is actively implementing principles of non-proliferation and export control of nuclear materials and/or equipment. The article deals with treaties, conventions, agreements and other international arrangements that are creating certain obligation for Republic of Croatia related to nuclear non-proliferation. The most important are the Treaty on the Non-proliferation of Nuclear Weapons, the Convention on the Physical Protection of Nuclear Material, the Agreement between the Republic of Croatia and the International Atomic Energy Agency for the Application of Safeguards with Protocol, the Protocol Additional to the Agreement Between the Republic of Croatia and the International Atomic Energy Agency for the Application of Safeguards, the Comprehensive Nuclear Test-Ban Treaty, the NSG Guidelines for the Export of Nuclear Material, Equipment and Technology and NSG Guidelines for Transfers of Nuclear-Related Dual-Use Equipment, Materials, Software and Related Technology. In addition the article describes a national regulative framework, the basis for conducting activities in nuclear material control, export control of dual-use items as well as non-proliferation of the weapons of mass destruction. Details are given about the Nuclear Safety Act, the Act on Liability for Nuclear Damage, the Act on Export of Dual-Use Items, the Decree on the List of Dual-Use Items, the Law on Production, Repair and Trade in Arms and Military Equipment and the Decree specifying goods subject to export and import licenses. (author)

Nuclear localization signal regulates porcine circovirus type 2 capsid protein nuclear export through phosphorylation.

Science.gov (United States)

Hou, Qiang; Hou, Shaohua; Chen, Qing; Jia, Hong; Xin, Ting; Jiang, Yitong; Guo, Xiaoyu; Zhu, Hongfei

2018-02-15

The open reading frame 2 (ORF2) of Porcine circovirus type 2 (PCV2) encodes the major Capsid (Cap) protein, which self-assembles into virus-like particle (VLP) of similar morphology to the PCV2 virion and accumulates in the nucleus through the N-terminal arginine-rich nuclear localization signal (NLS). In this study, PCV2 Cap protein and its derivates were expressed via the baculovirus expression system, and the cellular localization of the recombinant proteins were investigated using anti-Cap mAb by imaging flow cytometry. Analysis of subcellular localization of Cap protein and its variants demonstrated that NLS mediated Cap protein nuclear export as well as nuclear import, and a phosphorylation site (S17) was identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the NLS domain to regulate Cap protein nuclear export. Phosphorylation of NLS regulating the PCV2 Cap protein nuclear export was also demonstrated in PK15 cells by fluorescence microscopy. Moreover, the influence of Rep and Rep' protein on Cap protein subcellular localization was investigated in PK15 cells. Phosphorylation of NLS regulating Cap protein nuclear export provides more detailed knowledge of the PCV2 viral life cycle. Copyright © 2018 Elsevier B.V. All rights reserved.

NPT, export controls and nuclear trade

International Nuclear Information System (INIS)

Pande, Savita

1997-01-01

Nuclear trade has by and large remained unhampered vis-a-vis both the NPT as well as export control regulations. The NPT rules are regarded as insufficient, the guidelines appear to contravene the spirit of cooperation in trade and development between suppliers and recipients and there is no agreement among leading suppliers themselves on what constitutes the proper conduct of trade. Export control regimes are more or less too informal to be able to be implemented. The supplier states have to invariably depend on national legislations which again vary from country to country. The only common formal basis on which action can be taken is, therefore, the NPT, its loopholes notwithstanding. The idea of transparency, and supplier-recipient dialogue continues to be a myth and will continue to be so long as these regimes remain discriminatory, so long as some nations are more powerful than others by virtue of retaining nuclear weapons and superiority in nuclear technology and trade

The nuclear export protein of H5N1 influenza A viruses recruits Matrix 1 (M1) protein to the viral ribonucleoprotein to mediate nuclear export.

Science.gov (United States)

Brunotte, Linda; Flies, Joe; Bolte, Hardin; Reuther, Peter; Vreede, Frank; Schwemmle, Martin

2014-07-18

In influenza A virus-infected cells, replication and transcription of the viral genome occurs in the nucleus. To be packaged into viral particles at the plasma membrane, encapsidated viral genomes must be exported from the nucleus. Intriguingly, the nuclear export protein (NEP) is involved in both processes. Although NEP stimulates viral RNA synthesis by binding to the viral polymerase, its function during nuclear export implicates interaction with viral ribonucleoprotein (vRNP)-associated M1. The observation that both interactions are mediated by the C-terminal moiety of NEP raised the question whether these two features of NEP are linked functionally. Here we provide evidence that the interaction between M1 and the vRNP depends on the NEP C terminus and its polymerase activity-enhancing property for the nuclear export of vRNPs. This suggests that these features of NEP are linked functionally. Furthermore, our data suggest that the N-terminal domain of NEP interferes with the stability of the vRNP-M1-NEP nuclear export complex, probably mediated by its highly flexible intramolecular interaction with the NEP C terminus. On the basis of our data, we propose a new model for the assembly of the nuclear export complex of Influenza A vRNPs. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Identification of a putative nuclear export signal motif in human NANOG homeobox domain

International Nuclear Information System (INIS)

Park, Sung-Won; Do, Hyun-Jin; Huh, Sun-Hyung; Sung, Boreum; Uhm, Sang-Jun; Song, Hyuk; Kim, Nam-Hyung; Kim, Jae-Hwan

2012-01-01

Highlights: ► We found the putative nuclear export signal motif within human NANOG homeodomain. ► Leucine-rich residues are important for human NANOG homeodomain nuclear export. ► CRM1-specific inhibitor LMB blocked the potent human NANOG NES-mediated nuclear export. -- Abstract: NANOG is a homeobox-containing transcription factor that plays an important role in pluripotent stem cells and tumorigenic cells. To understand how nuclear localization of human NANOG is regulated, the NANOG sequence was examined and a leucine-rich nuclear export signal (NES) motif ( 125 MQELSNILNL 134 ) was found in the homeodomain (HD). To functionally validate the putative NES motif, deletion and site-directed mutants were fused to an EGFP expression vector and transfected into COS-7 cells, and the localization of the proteins was examined. While hNANOG HD exclusively localized to the nucleus, a mutant with both NLSs deleted and only the putative NES motif contained (hNANOG HD-ΔNLSs) was predominantly cytoplasmic, as observed by nucleo/cytoplasmic fractionation and Western blot analysis as well as confocal microscopy. Furthermore, site-directed mutagenesis of the putative NES motif in a partial hNANOG HD only containing either one of the two NLS motifs led to localization in the nucleus, suggesting that the NES motif may play a functional role in nuclear export. Furthermore, CRM1-specific nuclear export inhibitor LMB blocked the hNANOG potent NES-mediated export, suggesting that the leucine-rich motif may function in CRM1-mediated nuclear export of hNANOG. Collectively, a NES motif is present in the hNANOG HD and may be functionally involved in CRM1-mediated nuclear export pathway.

Nuclear fuel

International Nuclear Information System (INIS)

D Hondt, P.

1998-01-01

The research and development programme on nuclear fuel at the Belgian Nuclear Research Centre SCK/CEN is described. The objective of this programme is to enhance the quantitative prediction of the operational limits of nuclear fuel and to assess the behaviour of fuel under incidental and accidental conditions. Progress is described in different domains including the modelling of fission gas release in LWR fuel, thermal conductivity, basic physical phenomena, post-irradiation examination for fuel performance assessment, and conceptual studies of incidental and accidental fuel experiments

U.S. nuclear non-proliferation policy: impact on exports and nuclear industry could not be determined. Report to the Congress

International Nuclear Information System (INIS)

1980-01-01

The Nuclear Non-Proliferation Act of 1978 established new measures to prevent the diversion to weapons use of peaceful nuclear exports. It also created a policy to confirm U.S. reliability as a nuclear supplier. GAO did not identify any export sales lost as a result of the Act, but did find indications that nonproliferation policies can influence export sales. Based on available data, GAO could not determine the impact of the Act on the competitiveness of U.S. nuclear exports. However, U.S. companies are at some disadvantage because importers perceive that implementation of the Act may result in delayed export licenses. The United States dominated the nuclear export market through the early 1970s. However, foreign competitors, some aided by U.S. technology transfers, emerged to monopolize home markets and compete for third-country business. Further, the market has been depressed since 1974 and prospects for U.S. nuclear power plant exports have dimmed greatly. However, U.S. companies continue to view exports as important to sustain production capacity

Influenza polymerase encoding mRNAs utilize atypical mRNA nuclear export.

Science.gov (United States)

Larsen, Sean; Bui, Steven; Perez, Veronica; Mohammad, Adeba; Medina-Ramirez, Hilario; Newcomb, Laura L

2014-08-28

Influenza is a segmented negative strand RNA virus. Each RNA segment is encapsulated by influenza nucleoprotein and bound by the viral RNA dependent RNA polymerase (RdRP) to form viral ribonucleoproteins responsible for RNA synthesis in the nucleus of the host cell. Influenza transcription results in spliced mRNAs (M2 and NS2), intron-containing mRNAs (M1 and NS1), and intron-less mRNAs (HA, NA, NP, PB1, PB2, and PA), all of which undergo nuclear export into the cytoplasm for translation. Most cellular mRNA nuclear export is Nxf1-mediated, while select mRNAs utilize Crm1. Here we inhibited Nxf1 and Crm1 nuclear export prior to infection with influenza A/Udorn/307/1972(H3N2) virus and analyzed influenza intron-less mRNAs using cellular fractionation and reverse transcription-quantitative polymerase chain reaction (RT-qPCR). We examined direct interaction between Nxf1 and influenza intron-less mRNAs using immuno purification of Nxf1 and RT-PCR of associated RNA. Inhibition of Nxf1 resulted in less influenza intron-less mRNA export into the cytoplasm for HA and NA influenza mRNAs in both human embryonic kidney cell line (293 T) and human lung adenocarcinoma epithelial cell line (A549). However, in 293 T cells no change was observed for mRNAs encoding the components of the viral ribonucleoproteins; NP, PA, PB1, and PB2, while in A549 cells, only PA, PB1, and PB2 mRNAs, encoding the RdRP, remained unaffected; NP mRNA was reduced in the cytoplasm. In A549 cells NP, NA, HA, mRNAs were found associated with Nxf1 but PA, PB1, and PB2 mRNAs were not. Crm1 inhibition also resulted in no significant difference in PA, PB1, and PB2 mRNA nuclear export. These results further confirm Nxf1-mediated nuclear export is functional during the influenza life cycle and hijacked for select influenza mRNA nuclear export. We reveal a cell type difference for Nxf1-mediated nuclear export of influenza NP mRNA, a reminder that cell type can influence molecular mechanisms. Importantly, we

Nuclear technology and the export control laws

International Nuclear Information System (INIS)

Munroe, J.L.; Pankratz, M.C.; Hogsett, V.H.; Lundy, A.S.

1988-01-01

Three basic US laws regulate the export of commodities, services, and technical data. People working in nuclear fields need to know of these laws and their impact on professional endeavors. Export of technical data means the communication of any information by oral, written, or any other means to foreign nationals within or outside the US. The medium for the communication may be a model, blueprint, sketch, or any other device that can convey information. If the data relates to items on one of the control lists, a license must be sought from the appropriated federal agency. The Militarily Critical Technologies List (MCTL), though not itself a control list, plays a major role in determining what technical data will require a validated license. The US Department of Energy (DOE), through Technical Working Gorup (TWG) 11, is responsible for the Nuclear Technology chapter of the MCTL. TWG 11 also prepares the Nuclear Technology Reference Book (NTRB), a classified guide to sensitive nuclear technology

A study on the establishment of national nuclear foreign policy with reference to nuclear export control system, strategy toward IAEA, and NPT review conferences

International Nuclear Information System (INIS)

Choi, Young Myung; Nam, Jang Soo; Lee, Han Myung

1990-02-01

The objectives of this study are follows: suggestion for i) our future nuclear development directions, ii) establishment of national export control system, iii) establishment of strategy toward IAEA, and suggestion of our standpoints toward the 4th NPT review conference. This study proposes the following; 1) It is desirable that nuclear power generation strategy is propelled under the premise of economics and proven technology. And international cooperation in connection with the nuclear fuel cycle should be reinforced. 2) It is recommened that nuclear export control system should be government-led. 3) Our country needs to make efforts in increasing the number of Korean staff in the IAEA, and to establish permanent mission which is wholly responsible for the IAEA affairs, and to construct a system which deals with nuclear foregin activities. 4) It is desirable that the basic position of our country toward the 4th NPT review conference should be : i) to urge parties to the NPT to conclude safeguards agreement with IAEA as early as possible, ii) to request nuclear suppliers to mitigate their nuclear technology for peaceful uses to nuclear developing countries, and iii) to urge nuclear weapon states to make further efforts for nuclear disarmament. (author)

A comparative study on export control systems of nuclear technology in ROK and USA

Energy Technology Data Exchange (ETDEWEB)

Tae, Jae Woong; Shin, Dong Hoon [Korea Institute of Nuclear Nonproliferation and Control, Daejeon (Korea, Republic of)

2013-10-15

Perfect removal of transferred technology is impossible because it is impossible to find all copies of technologies such as files and documents. International community concerns about Terrorists' acquirement of nuclear technologies related to nuclear reactors, enrichment and reprocessing Facilities and heavy water production facilities, which can be used for production of nuclear weapons. Non-state actors as well as concerning countries have tried to possess nuclear technology for developing nuclear weapons. Non-state actors' activities threaten global nuclear security. Korea exported four nuclear power plants to UAE and a research reactor to Jordan. Non-state actors may try to procure nuclear equipment and technology from Korean nuclear industries. Therefore, the export control system should be enhanced for national nuclear security and safety. In this study, the export control system of Korea and the United States were compared concerning to nuclear technology. In summary, controlled activities related to nuclear technology are treated more variously and more diverse activities are controlled in the United States than In Korea. Catch-all control will lose its effectiveness without this. Related to the control of ITT (Intangible Technology Transfer), Korea and the United States are trying to amend the export control regulation. Both of them are trying to control intangible technology transfers effectively. Revised Foreign Trade Act in Korea is expected to introduce a more rigorous system of nuclear technology controls. It focuses on nationality rather than residence. The revised law may face into other problems such as dual nationals like as the United States. However, this satisfies legislative requirements for control of a deemed export. The revised law will enter into force in 2014. Accurate meanings of technology and export will be defined soon in the enforcement decree and the public notice before 2014. However, it is hard to revise the definition

A comparative study on export control systems of nuclear technology in ROK and USA

International Nuclear Information System (INIS)

Tae, Jae Woong; Shin, Dong Hoon

2013-01-01

Perfect removal of transferred technology is impossible because it is impossible to find all copies of technologies such as files and documents. International community concerns about Terrorists' acquirement of nuclear technologies related to nuclear reactors, enrichment and reprocessing Facilities and heavy water production facilities, which can be used for production of nuclear weapons. Non-state actors as well as concerning countries have tried to possess nuclear technology for developing nuclear weapons. Non-state actors' activities threaten global nuclear security. Korea exported four nuclear power plants to UAE and a research reactor to Jordan. Non-state actors may try to procure nuclear equipment and technology from Korean nuclear industries. Therefore, the export control system should be enhanced for national nuclear security and safety. In this study, the export control system of Korea and the United States were compared concerning to nuclear technology. In summary, controlled activities related to nuclear technology are treated more variously and more diverse activities are controlled in the United States than In Korea. Catch-all control will lose its effectiveness without this. Related to the control of ITT (Intangible Technology Transfer), Korea and the United States are trying to amend the export control regulation. Both of them are trying to control intangible technology transfers effectively. Revised Foreign Trade Act in Korea is expected to introduce a more rigorous system of nuclear technology controls. It focuses on nationality rather than residence. The revised law may face into other problems such as dual nationals like as the United States. However, this satisfies legislative requirements for control of a deemed export. The revised law will enter into force in 2014. Accurate meanings of technology and export will be defined soon in the enforcement decree and the public notice before 2014. However, it is hard to revise the definition of export

Murine Leukemia Virus Uses TREX Components for Efficient Nuclear Export of Unspliced Viral Transcripts

Directory of Open Access Journals (Sweden)

Toshie Sakuma

2014-03-01

Full Text Available Previously we reported that nuclear export of both unspliced and spliced murine leukemia virus (MLV transcripts depends on the nuclear export factor (NXF1 pathway. Although the mRNA export complex TREX, which contains Aly/REF, UAP56, and the THO complex, is involved in the NXF1-mediated nuclear export of cellular mRNAs, its contribution to the export of MLV mRNA transcripts remains poorly understood. Here, we studied the involvement of TREX components in the export of MLV transcripts. Depletion of UAP56, but not Aly/REF, reduced the level of both unspliced and spliced viral transcripts in the cytoplasm. Interestingly, depletion of THO components, including THOC5 and THOC7, affected only unspliced viral transcripts in the cytoplasm. Moreover, the RNA immunoprecipitation assay showed that only the unspliced viral transcript interacted with THOC5. These results imply that MLV requires UAP56, THOC5 and THOC7, in addition to NXF1, for nuclear export of viral transcripts. Given that naturally intronless mRNAs, but not bulk mRNAs, require THOC5 for nuclear export, it is plausible that THOC5 plays a key role in the export of unspliced MLV transcripts.

Export and import. Conformity with regulations

International Nuclear Information System (INIS)

Shapar, M.

1976-01-01

Since the division of the former US Atomic Energy Commission's tasks, the regulation and control of import and export of nuclear materials and equipment has become the responsability of the Nuclear Regulatory Commission (NRC). The import and export of nuclear fuels, equipment and reactors are therefore subject to prior licensing by the Commission. This requirement aims to guarantee that such activities will not create serious hazards for defense and national safety, and that the exported products will not be diverted from their peaceful uses. The relevant applicable legal provisions are based on the Atomic Energy Act of 1954 and on the detailed regulations issued by the Commission. Under the pressure of public opinion, there is a current tendency to restrict these activities because of the hazards they present, in particular during transport, until the Commission has completed all the necessary studies. (NEA) [fr

A study on the revision of nuclear safety act to build the foundation of nuclear export and import control system in Korea

International Nuclear Information System (INIS)

Yang, Seung Hyo; Choi, Sun Do

2012-01-01

Nuclear related items require export and import control beyond the multilateral export control system according to Safeguard Agreement, Additional Protocol and bilateral agreements. Besides Korea as a nuclear supplier is needed to actively cope with its export control system, which is being reinforced internationally. In regard to this trend, this study drew the revision plan of present Nuclear Safety Act to found the nuclear export and import control system in Korea by examining the related legislations and analyzing the implementation status of nuclear export and import control

A study on the revision of nuclear safety act to build the foundation of nuclear export and import control system in Korea

Energy Technology Data Exchange (ETDEWEB)

Yang, Seung Hyo; Choi, Sun Do [Korea Institute of Nuclear Nonproliferation and Control, Daejeon (Korea, Republic of)

2012-10-15

Nuclear related items require export and import control beyond the multilateral export control system according to Safeguard Agreement, Additional Protocol and bilateral agreements. Besides Korea as a nuclear supplier is needed to actively cope with its export control system, which is being reinforced internationally. In regard to this trend, this study drew the revision plan of present Nuclear Safety Act to found the nuclear export and import control system in Korea by examining the related legislations and analyzing the implementation status of nuclear export and import control.

A study on establishing export system of nuclear related equipments to the IAEA

Energy Technology Data Exchange (ETDEWEB)

Song, Ki Dong; Lee, Man Ki; Moon, Ki Hwan; Kim, Seung Soo; Lim, Chae Young; Kim, Hwa Sup; Min, Tae Sik [Korea Atomic Energy Research Institute, Taejeon (Korea)

2002-04-01

In spite of the advanced status in the international nuclear society, exports of domestic nuclear industries to procurement market of the international organizations has been negligible. This study briefly explained the role and the structure of the IAEA. Then, this study surveyed the size of procurement market, major procurement items, and procurement process. This study also gave an export example to the IAEA from Korea Atomic Energy Research Institute for the ease of understanding the procurement process. Based on these surveys and analysis, this study established the goal and strategy for exports of nuclear equipments to the IAEA. Besides, this study surveyed domestic nuclear industries that have potential to export their products to the IAEA. Then, Korea Atomic Energy Research Institute, by a cooperation with Korea Atomic Industrial Forum Inc., held workshop on 'export of nuclear equipments to IAEA' in May 2001 for them. 4 refs., 1 fig., 10 tabs. (Author)

ENUSA in the international market of nuclear fuel

International Nuclear Information System (INIS)

Gutierrez, J. E.; Gonzalez, R.

2002-01-01

ENUSA Industrias Avanzadas, s. a. has a promising future into the nuclear fuel world market evolving from a starting model of a state owned company focused on the Spanish market and using exclusively the technology coming from their American partners, to a current model of a modern company where technological innovation, the competitiveness and the quality are key factors in the developments of his business. ENUSA is a company oriented to the export sustained by the integrated services provided to the Spanish nuclear sector,where Europe is his natural market, but open to seek opportunities together with his technological partners into the American and Japanese market. (Author)

Inhibiting cancer cell hallmark features through nuclear export inhibition.

Science.gov (United States)

Sun, Qingxiang; Chen, Xueqin; Zhou, Qiao; Burstein, Ezra; Yang, Shengyong; Jia, Da

2016-01-01

Treating cancer through inhibition of nuclear export is one of the best examples of basic research translation into clinical application. Nuclear export factor chromosomal region maintenance 1 (CRM1; Xpo1 and exportin-1) controls cellular localization and function of numerous proteins that are critical for the development of many cancer hallmarks. The diverse actions of CRM1 are likely to explain the broad ranging anti-cancer potency of CRM1 inhibitors observed in pre-clinical studies and/or clinical trials (phase I-III) on both advanced-stage solid and hematological tumors. In this review, we compare and contrast the mechanisms of action of different CRM1 inhibitors, and discuss the potential benefit of unexplored non-covalent CRM1 inhibitors. This emerging field has uncovered that nuclear export inhibition is well poised as an attractive target towards low-toxicity broad-spectrum potent anti-cancer therapy.

Know-how and nuclear exports

International Nuclear Information System (INIS)

Luxo, A.

1978-01-01

The concrete content of nuclear know-how is defined, and the present position as to the exchange of know-how is discussed. The new forms which may be taken by this know-how are considered and the results which may be expected from a know-how transfer (both for the exporting and the importing countries) are related [fr

40 CFR 80.1430 - Requirements for exporters of renewable fuels.

Science.gov (United States)

2010-07-01

... of renewable fuel in the blend. (2) Determination of the renewable portion of the blend using Method... method as approved by the EPA. (3) Assuming the maximum concentration of the renewable fuel in the blend... its neat form or blended with gasoline or diesel, that is exported from any of the regions described...

A study on establishing export system of nuclear related equipments to the IAEA

Energy Technology Data Exchange (ETDEWEB)

Song, Ki Dong; Lee, Man Ki; Moon, Ki Hwan; Kim, Seung Soo; Lim, Chae Young; Kim, Hwa Sup; Min, Tae Sik [Korea Atomic Energy Research Institute, Taejeon (Korea)

2002-04-01

In spite of the advanced status in the international nuclear society, exports of domestic nuclear industries to procurement market of the international organizations has been negligible. This study briefly explained the role and the structure of the IAEA. Then, this study surveyed the size of procurement market, major procurement items, and procurement process. This study also gave an export example to the IAEA from Korea Atomic Energy Research Institute for the ease of understanding the procurement process. Based on these surveys and analysis, this study established the goal and strategy for exports of nuclear equipments to the IAEA. Besides, this study surveyed domestic nuclear industries that have potential to export their products to the IAEA. Then, Korea Atomic Energy Research Institute, by a cooperation with Korea Atomic Industrial Forum Inc., held workshop on 'export of nuclear equipments to IAEA' in May 2001 for them. 4 refs., 1 fig., 10 tabs. (Author)

Nuclear export policy of the Reagan Administration

Energy Technology Data Exchange (ETDEWEB)

Pilat, J F; Donnelly, W H [Library of Congress, Washington, DC (USA)

1983-06-01

The Reagan Administration maintains the Carter Administration's objective of non-proliferation of nuclear weapons as being fundamental to US nuclear export policy. However, it sees the USA as having another important role to play in influencing the use of nuclear power and the trading of related goods and technologies in other countries. While the Administration believes its policies will prove beneficial to the USA, there is concern that trade considerations are being given priority over preventing the proliferation of nuclear weapons.

Integration of renewable energies and nuclear power into North African Energy Systems: An analysis of energy import and export effects

International Nuclear Information System (INIS)

Supersberger, Nikolaus; Fuehrer, Laura

2011-01-01

The North African countries Morocco, Algeria, Tunisia, Libya and Egypt have been and are currently experiencing rapid growth in energy demand. This development confronts their political leaders with the question of how to expand or diversify their countries' generation capacities. In this context, renewable energies and nuclear power constitute options that have rarely been exploited so far in the region. This article analyzes the drawbacks and benefits of both alternatives, with a special focus on import and export dynamics. When attempting to make the strategic decision between renewables and atomic power, North African regional specifics and circumstances have to be taken into account. Hence, in a first step, the article characterizes the energy systems of the North African countries and presents scenarios for their future development. In a second step, it scrutinizes the energy challenges these states face in terms of domestic concerns and foreign affairs. Finally, a case study of Algeria is used to demonstrate how renewable energies, but not nuclear power, are able to respond to North African energy challenges. - Research highlights: → Using nuclear power would require fuel imports over the entire operation time. → Hence, energy exporters (Algeria, Libya) would become dependent on fuel imports. → Renewable energies can make North African countries less fuel import dependent. → Nuclear technologies would have to be imported over the whole life cycle of plants. → Domestic production for renewables technologies could be established after a first phase of technology imports.

Nuclear fuel

Energy Technology Data Exchange (ETDEWEB)

Nakano, H [Power Reactor and Nuclear Fuel Development Corp., Tokyo (Japan)

1976-10-01

It is expected that nuclear power generation will reach 49 million kW in 1985 and 129 million kW in 1995, and the nuclear fuel having to be supplied and processed will increase in proportion to these values. The technical problems concerning nuclear fuel are presented on the basis of the balance between the benefit for human beings and the burden on the human beings. Recently, especially the downstream of nuclear fuel attracts public attention. Enriched uranium as the raw material for light water reactor fuel is almost monopolized by the U.S., and the technical information has not been published for fear of the diversion to nuclear weapons. In this paper, the present situations of uranium enrichment, fuel fabrication, transportation, reprocessing and waste disposal and the future problems are described according to the path of nuclear fuel cycle. The demand and supply of enriched uranium in Japan will be balanced up to about 1988, but afterwards, the supply must rely upon the early establishment of the domestic technology by centrifugal separation method. No problem remains in the fabrication of light water reactor fuel, but for the fabrication of mixed oxide fuel, the mechanization of the production facility and labor saving are necessary. The solution of the capital risk for the construction of the second reprocessing plant is the main problem. Japan must develop waste disposal techniques with all-out efforts.

A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.

Science.gov (United States)

Volpon, Laurent; Culjkovic-Kraljacic, Biljana; Sohn, Hye Seon; Blanchet-Cohen, Alexis; Osborne, Michael J; Borden, Katherine L B

2017-06-01

The eukaryotic translation initiation factor eIF4E acts in the nuclear export and translation of a subset of mRNAs. Both of these functions contribute to its oncogenic potential. While the biochemical mechanisms that underlie translation are relatively well understood, the molecular basis for eIF4E's role in mRNA export remains largely unexplored. To date, over 3000 transcripts, many encoding oncoproteins, were identified as potential nuclear eIF4E export targets. These target RNAs typically contain a ∼50-nucleotide eIF4E sensitivity element (4ESE) in the 3' UTR and a 7-methylguanosine cap on the 5' end. While eIF4E associates with the cap, an unknown factor recognizes the 4ESE element. We previously identified cofactors that functionally interacted with eIF4E in mammalian cell nuclei including the leucine-rich pentatricopeptide repeat protein LRPPRC and the export receptor CRM1/XPO1. LRPPRC simultaneously interacts with both eIF4E bound to the 5' mRNA cap and the 4ESE element in the 3' UTR. In this way, LRPPRC serves as a specificity factor to recruit 4ESE-containing RNAs within the nucleus. Further, we show that CRM1 directly binds LRPPRC likely acting as the export receptor for the LRPPRC-eIF4E-4ESE RNA complex. We also found that Importin 8, the nuclear importer for cap-free eIF4E, imports RNA-free LRPPRC, potentially providing both coordinated nuclear recycling of the export machinery and an important surveillance mechanism to prevent futile export cycles. Our studies provide the first biochemical framework for the eIF4E-dependent mRNA export pathway. © 2017 Volpon et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

How the Eximbank helps US nuclear exporters

International Nuclear Information System (INIS)

Moore, J.L. Jr.

1981-01-01

The way in which the Export-Import Bank operates in support of the United States nuclear industry noting particularly its flexibility in responding to changing needs and budget constraints is described. (author)

The Nuclear Fuel Cycle

International Nuclear Information System (INIS)

2011-08-01

This brochure describes the nuclear fuel cycle, which is an industrial process involving various activities to produce electricity from uranium in nuclear power reactors. The cycle starts with the mining of uranium and ends with the disposal of nuclear waste. The raw material for today's nuclear fuel is uranium. It must be processed through a series of steps to produce an efficient fuel for generating electricity. Used fuel also needs to be taken care of for reuse and disposal. The nuclear fuel cycle includes the 'front end', i.e. preparation of the fuel, the 'service period' in which fuel is used during reactor operation to generate electricity, and the 'back end', i.e. the safe management of spent nuclear fuel including reprocessing and reuse and disposal. If spent fuel is not reprocessed, the fuel cycle is referred to as an 'open' or 'once-through' fuel cycle; if spent fuel is reprocessed, and partly reused, it is referred to as a 'closed' nuclear fuel cycle.

Analysis of factors affecting the implementation of back-end nuclear fuel cycle policy in Korea

International Nuclear Information System (INIS)

Choi, Yung Myung; Yang, Maeng Ho; Kim, Hyun Joon; Chung, Hwan Sam; Oh, Keun Bae; Lee, Byung OoK; Ko, Han Suk; Song, Ki Dong; Lee, Man Ki; Moon, Ki Hwan; Lee, Han Myung

1994-01-01

In this study, the back-end nuclear fuel cycle acceptability is surveyed and analyzed in the following three aspects. To begin with, the future political situation and energy-environmental issues are analyzed as part of the socio-economic aspect. Secondly, the domestic situation of nuclear industries and the fuel cycle policy of foreign countries are surveyed as the technical aspect. Finally, NPT, IAEA safeguards and nuclear export control regimes are analyzed as the institutional aspect. The unification period of South and North Korea also will greatly affect the implementation of back-end fuel cycle policy, and public attitudes will affect the acquisition of site, construction, and operation of nuclear facilities. An effort to release international restrictions on the back-end fuel cycle is also required to accelerate the implementation of the policy. In this regard, the back-end fuel cycle policy should be clear-cut to avoid misunderstanding with respect to nuclear proliferation. Importantly, agreements with foreign countries should be amended at a mutual equivalent level. (Author) 30 refs., 5 figs., 25 tabs

Analysis of factors affecting the implementation of back-end nuclear fuel cycle policy in Korea

Energy Technology Data Exchange (ETDEWEB)

Choi, Yung Myung; Yang, Maeng Ho; Kim, Hyun Joon; Chung, Hwan Sam; Oh, Keun Bae; Lee, Byung OoK; Ko, Han Suk; Song, Ki Dong; Lee, Man Ki; Moon, Ki Hwan; Lee, Han Myung [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

1994-01-01

In this study, the back-end nuclear fuel cycle acceptability is surveyed and analyzed in the following three aspects. To begin with, the future political situation and energy-environmental issues are analyzed as part of the socio-economic aspect. Secondly, the domestic situation of nuclear industries and the fuel cycle policy of foreign countries are surveyed as the technical aspect. Finally, NPT, IAEA safeguards and nuclear export control regimes are analyzed as the institutional aspect. The unification period of South and North Korea also will greatly affect the implementation of back-end fuel cycle policy, and public attitudes will affect the acquisition of site, construction, and operation of nuclear facilities. An effort to release international restrictions on the back-end fuel cycle is also required to accelerate the implementation of the policy. In this regard, the back-end fuel cycle policy should be clear-cut to avoid misunderstanding with respect to nuclear proliferation. Importantly, agreements with foreign countries should be amended at a mutual equivalent level. (Author) 30 refs., 5 figs., 25 tabs.

U.S. Department of Energy operational experience with shipments of foreign research reactor spent nuclear fuel

International Nuclear Information System (INIS)

Messick, Charles E.; Massey, Charles D.; Mustin, Tracy P.

1998-01-01

On May 13, 1996, the U.S. Department of Energy issued a Record of Decision on a Nuclear Weapons Nonproliferation Policy Concerning Foreign Research Reactor Spent Nuclear Fuel. The goal of the long-term policy is to recover enriched uranium exported from the United States, while giving foreign research reactor operators sufficient time to develop their own long-term solutions for storage and disposal of spent fuel. The spent fuel accepted by the U.S. DOE under the policy must be out of the research reactors by May 12, 2006 and returned to the United States by May 12, 2009. (author)

Selective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP

Science.gov (United States)

Wickramasinghe, Vihandha O.; Andrews, Robert; Ellis, Peter; Langford, Cordelia; Gurdon, John B.; Stewart, Murray; Venkitaraman, Ashok R.; Laskey, Ronald A.

2014-01-01

The nuclear phase of the gene expression pathway culminates in the export of mature messenger RNAs (mRNAs) to the cytoplasm through nuclear pore complexes. GANP (germinal- centre associated nuclear protein) promotes the transfer of mRNAs bound to the transport factor NXF1 to nuclear pore complexes. Here, we demonstrate that GANP, subunit of the TRanscription-EXport-2 (TREX-2) mRNA export complex, promotes selective nuclear export of a specific subset of mRNAs whose transport depends on NXF1. Genome-wide gene expression profiling showed that half of the transcripts whose nuclear export was impaired following NXF1 depletion also showed reduced export when GANP was depleted. GANP-dependent transcripts were highly expressed, yet short-lived, and were highly enriched in those encoding central components of the gene expression machinery such as RNA synthesis and processing factors. After injection into Xenopus oocyte nuclei, representative GANP-dependent transcripts showed faster nuclear export kinetics than representative transcripts that were not influenced by GANP depletion. We propose that GANP promotes the nuclear export of specific classes of mRNAs that may facilitate rapid changes in gene expression. PMID:24510098

Development of Export Control Comprehensive Management Model for Nuclear Power Plants and Others Projects

Energy Technology Data Exchange (ETDEWEB)

Lee, Chansuh; Seo, Hana; Choi, Sundo [Korea Institute of Nuclear Nonproliferation And Control, Daejeon (Korea, Republic of)

2014-05-15

It is required that there are lots of managements of care and concern if the project contains strategic items such as NPPs. The Korean nuclear industry and its related companies, such as the Korea Hydro and Nuclear Power (KHNP), are promoting greater exports of NPPs. It is likely that Korea will export more this technology to newcomer states in the future. As a result, the ROK has been improving its export control management system for NPPs. In keeping with this national effort, Korea Institute of Nuclear Nonproliferation And Control (KINAC) developed comprehensive export control management model for NPPs and other projects, in preparation for this projected growth in the industry. This model also applies to the nuclear export case of the UAE, aims to manage the project from bidding to the end of the contract. The recent Export Licensing of Nuclear Facility Technology was reflected in the Notice on Export and Import of Strategic Items in January 2014. Through this license, the large-scale project legislation framework was established. It can also minimize nonproliferation concerns of the international community through strict management. It is expected that the Korea will be able to enhance transparency and secure the nuclear use, while meeting nonproliferation purpose.

Development of Export Control Comprehensive Management Model for Nuclear Power Plants and Others Projects

International Nuclear Information System (INIS)

Lee, Chansuh; Seo, Hana; Choi, Sundo

2014-01-01

It is required that there are lots of managements of care and concern if the project contains strategic items such as NPPs. The Korean nuclear industry and its related companies, such as the Korea Hydro and Nuclear Power (KHNP), are promoting greater exports of NPPs. It is likely that Korea will export more this technology to newcomer states in the future. As a result, the ROK has been improving its export control management system for NPPs. In keeping with this national effort, Korea Institute of Nuclear Nonproliferation And Control (KINAC) developed comprehensive export control management model for NPPs and other projects, in preparation for this projected growth in the industry. This model also applies to the nuclear export case of the UAE, aims to manage the project from bidding to the end of the contract. The recent Export Licensing of Nuclear Facility Technology was reflected in the Notice on Export and Import of Strategic Items in January 2014. Through this license, the large-scale project legislation framework was established. It can also minimize nonproliferation concerns of the international community through strict management. It is expected that the Korea will be able to enhance transparency and secure the nuclear use, while meeting nonproliferation purpose

Nuclear Export of Pre-Ribosomal Subunits Requires Dbp5, but Not as an RNA-Helicase as for mRNA Export.

Science.gov (United States)

Neumann, Bettina; Wu, Haijia; Hackmann, Alexandra; Krebber, Heike

2016-01-01

The DEAD-box RNA-helicase Dbp5/Rat8 is known for its function in nuclear mRNA export, where it displaces the export receptor Mex67 from the mRNA at the cytoplasmic side of the nuclear pore complex (NPC). Here we show that Dbp5 is also required for the nuclear export of both pre-ribosomal subunits. Yeast temperature-sensitive dbp5 mutants accumulate both ribosomal particles in their nuclei. Furthermore, Dbp5 genetically and physically interacts with known ribosomal transport factors such as Nmd3. Similar to mRNA export we show that also for ribosomal transport Dbp5 is required at the cytoplasmic side of the NPC. However, unlike its role in mRNA export, Dbp5 does not seem to undergo its ATPase cycle for this function, as ATPase-deficient dbp5 mutants that selectively inhibit mRNA export do not affect ribosomal transport. Furthermore, mutants of GLE1, the ATPase stimulating factor of Dbp5, show no major ribosomal export defects. Consequently, while Dbp5 uses its ATPase cycle to displace the export receptor Mex67 from the translocated mRNAs, Mex67 remains bound to ribosomal subunits upon transit to the cytoplasm, where it is detectable on translating ribosomes. Therefore, we propose a model, in which Dbp5 supports ribosomal transport by capturing ribosomal subunits upon their cytoplasmic appearance at the NPC, possibly by binding export factors such as Mex67. Thus, our findings reveal that although different ribonucleoparticles, mRNAs and pre-ribosomal subunits, use shared export factors, they utilize different transport mechanisms.

French nuclear industry exportations: companies and organisations, achievements and projects

International Nuclear Information System (INIS)

Faudon, V.; Pailler, S.; Miniere, D.; Pouget-Abadie, X.; Journes, F.; Ouali, F.; Brochard, D.; Choho, T.; Lagarde, D.; Anglaret, P.; Kottman, G.; Mockly, D.; Ouzounian, G.; Cordier, P.Y.; Prenez, J.C.; Arpino, J.M.; Jaouen, C.; Jolly, B.

2013-01-01

This document gathers a series of short articles in which the following players: French Nuclear Safety Authority (ASN), Electricity of France (EdF), French Alternative Energies and Atomic Energy Commission (CEA), AREVA, ALSTOM, the Association of French Nuclear Industry Exporters (AIFEN), the National Radioactive Waste Management Agency (ANDRA) and the French Society of Nuclear Energy (SFEN) present their competencies in their respective fields and their strategies and commercial offers for exports. 2 articles are dedicated to the achievements of the French nuclear industry in China and another details the cooperation between SFEN and its foreign counterparts. Another article briefly presents the EPR and ATMEA reactors. (A.C.)

Nuclear fuels

International Nuclear Information System (INIS)

2008-01-01

The nuclear fuel is one of the key component of a nuclear reactor. Inside it, the fission reactions of heavy atoms, uranium and plutonium, take place. It is located in the core of the reactor, but also in the core of the whole nuclear system. Its design and properties influence the behaviour, the efficiency and the safety of the reactor. Even if it represents a weak share of the generated electricity cost, its proper use represents an important economic stake. Important improvements remain to be made to increase its residence time inside the reactor, to supply more energy, and to improve its robustness. Beyond the economical and safety considerations, strategical questions have to find an answer, like the use of plutonium, the management of resources and the management of nuclear wastes and real technological challenges have to be taken up. This monograph summarizes the existing knowledge about the nuclear fuel, its behaviour inside the reactor, its limits of use, and its R and D tracks. It illustrates also the researches in progress and presents some key results obtained recently. Content: 1 - Introduction; 2 - The fuel of water-cooled reactors: aspect, fabrication, behaviour of UO 2 and MOX fuels inside the reactor, behaviour in loss of tightness situation, microscopic morphology of fuel ceramics and evolution under irradiation - migration and localisation of fission products in UOX and MOX matrices, modeling of fuels behaviour - modeling of defects and fission products in the UO 2 ceramics by ab initio calculations, cladding and assembly materials, pellet-cladding interaction, advanced UO 2 and MOX ceramics, mechanical behaviour of the fuel assembly, fuel during a loss of coolant accident, fuel during a reactivity accident, fuel during a serious accident, fuel management inside reactor cores, fuel cycle materials balance, long-term behaviour of the spent fuel, fuel of boiling water reactors; 3 - the fuel of liquid metal fast reactors: fast neutrons radiation

Fuel-consumption reflects increasing export

International Nuclear Information System (INIS)

TREND

2003-01-01

Fuel consumption in Slovakia has been substantially rising during the first three months of this year. During January and February about 6 percent more petrol and 15 percent more diesel fuel were sold compared to last year. Retail sales were growing even faster, informed president of Slovak Association of Petroleum Industry and Trade (SAPPO), Karoly Robak. He considers this an evidence of a substantial economic growth. The export is executed in form of freight transport (lorries), as this, together with agriculture, is the largest diesel fuel consumer. K. Robak, who at the same time is the Deputy General Manager For Retail at Slovnaft, a.s., Bratislava, expects the sales of fuel to grow by about 8 percent this year. Low prices due to a weaker US dollar should only support these tendencies. Last year the sales grew by 8,3 percent and in retail business the increase exceeded 10 percent. At the moment there are about 700 petrol stations in Slovakia (SAPPO) and over 330 out of them are owned by Slovnaft. The sale of fuel is now moving more to the retail business - to petrol stations as the price difference between retail and wholesale is decreasing. Last year for instance the wholesale recorded an increase in sales of diesel by 6,5 percent whereas retail sales grew by 17 percent. With petrol the situation was similar - 6,4 increase in retail sales and 2,5 percent in wholesale. (Author)

Fuel and nuclear fuel cycle

International Nuclear Information System (INIS)

Prunier, C.

1998-01-01

The nuclear fuel is studied in detail, the best choice and why in relation with the type of reactor, the properties of the fuel cans, the choice of fuel materials. An important part is granted to the fuel assembly of PWR type reactor and the performances of nuclear fuels are tackled. The different subjects for research and development are discussed and this article ends with the particular situation of mixed oxide fuels ( materials, behavior, efficiency). (N.C.)

Problems associated with the export of nuclear power plants

International Nuclear Information System (INIS)

1978-01-01

Full text: Recent forecasts indicate that by the year 2000 there will be more than 1000 nuclear power plants operating in 50 countries and with several countries expecting to derive one-half or more of their electric generation from nuclear power plants At present only six countries are exporters of nuclear power systems, three more currently supply their own domestic markets, while the remainder are importers. It is expected that most of the importers will continue to depend to varying degrees on foreign supply, at least in the near future. If nuclear power is to offer an important benefit to the world, the achievement of this benefit will require co-operation between the supplying and receiving nations in overcoming problems which might inhibit the full development of this energy source. In addition to ensuring safety and reliability, special problem areas include financing, skilled manpower needs, adequate local industrial and engineering infrastructure, access to advanced technology, and an assured supply of nuclear fuel. The symposium had special emphasis on the problems facing many of the developing countries in the initial stages of nuclear power programmes, and was divided into three major topics nuclear safety, domestic contributions, and international aspects In the safety area, emphasis was given to the special considerations that may exist for countries that import nuclear plants. These special considerations can be due to some non-standard features of the exported reactor such as lower power ratings, dissimilar site characteristics that can effect the design, and the evolution and changes in design and safety requirements during construction. This can be complicated by differences in safety philosophy and codified standards of the various suppliers and unique construction problems in the less developed countries. Thus, the ability of the importing country to carry out the regulatory and safety function is obviously important. A number of presentations

Nuclear export of RNA: Different sizes, shapes and functions.

Science.gov (United States)

Williams, Tobias; Ngo, Linh H; Wickramasinghe, Vihandha O

2018-03-01

Export of protein-coding and non-coding RNA molecules from the nucleus to the cytoplasm is critical for gene expression. This necessitates the continuous transport of RNA species of different size, shape and function through nuclear pore complexes via export receptors and adaptor proteins. Here, we provide an overview of the major RNA export pathways in humans, highlighting the similarities and differences between each. Its importance is underscored by the growing appreciation that deregulation of RNA export pathways is associated with human diseases like cancer. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

Romanian nuclear fuel program

International Nuclear Information System (INIS)

Budan, O.

1999-01-01

The paper presents and comments the policy adopted in Romania for the production of CANDU-6 nuclear fuel before and after 1990. The CANDU-6 nuclear fuel manufacturing started in Romania in December 1983. Neither AECL nor any Canadian nuclear fuel manufacturer were involved in the Romanian industrial nuclear fuel production before 1990. After January 1990, the new created Romanian Electricity Authority (RENEL) assumed the responsibility for the Romanian Nuclear Power Program. It was RENEL's decision to stop, in June 1990, the nuclear fuel production at the Institute for Nuclear Power Reactors (IRNE) Pitesti. This decision was justified by the Canadian specialists team findings, revealed during a general, but well enough technically founded analysis performed at IRNE in the spring of 1990. All fuel manufactured before June 1990 was quarantined as it was considered of suspect quality. By that time more than 31,000 fuel bundles had already been manufactured. This fuel was stored for subsequent assessment. The paper explains the reasons which provoked this decision. The paper also presents the strategy adopted by RENEL after 1990 regarding the Romanian Nuclear Fuel Program. After a complex program done by Romanian and Canadian partners, in November 1994, AECL issued a temporary certification for the Romanian nuclear fuel plant. During the demonstration manufacturing run, as an essential milestone for the qualification of the Romanian fuel supplier for CANDU-6 reactors, 202 fuel bundles were produced. Of these fuel bundles, 66 were part of the Cernavoda NGS Unit 1 first fuel load (the balance was supplied by Zircatec Precision Industries Inc. ZPI). The industrial nuclear fuel fabrication re-started in Romania in January 1995 under AECL's periodical monitoring. In December 1995, AECL issued a permanent certificate, stating the Romanian nuclear fuel plant as a qualified and authorised CANDU-6 fuel supplier. The re-loading of the Cernavoda NGS Unit 1 started in the middle

Inner nuclear envelope protein SUN1 plays a prominent role in mammalian mRNA export.

Science.gov (United States)

Li, Ping; Noegel, Angelika A

2015-11-16

Nuclear export of messenger ribonucleoproteins (mRNPs) through the nuclear pore complex (NPC) can be roughly classified into two forms: bulk and specific export, involving an nuclear RNA export factor 1 (NXF1)-dependent pathway and chromosome region maintenance 1 (CRM1)-dependent pathway, respectively. SUN proteins constitute the inner nuclear envelope component of the l I: nker of N: ucleoskeleton and C: ytoskeleton (LINC) complex. Here, we show that mammalian cells require SUN1 for efficient nuclear mRNP export. The results indicate that both SUN1 and SUN2 interact with heterogeneous nuclear ribonucleoprotein (hnRNP) F/H and hnRNP K/J. SUN1 depletion inhibits the mRNP export, with accumulations of both hnRNPs and poly(A)+RNA in the nucleus. Leptomycin B treatment indicates that SUN1 functions in mammalian mRNA export involving the NXF1-dependent pathway. SUN1 mediates mRNA export through its association with mRNP complexes via a direct interaction with NXF1. Additionally, SUN1 associates with the NPC through a direct interaction with Nup153, a nuclear pore component involved in mRNA export. Taken together, our results reveal that the inner nuclear envelope protein SUN1 has additional functions aside from being a central component of the LINC complex and that it is an integral component of the mammalian mRNA export pathway suggesting a model whereby SUN1 recruits NXF1-containing mRNP onto the nuclear envelope and hands it over to Nup153. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Nuclear fuel element

International Nuclear Information System (INIS)

1974-01-01

A nuclear fuel element for use in the core of a nuclear reactor is disclosed. A heat conducting fission product retaining metal liner of a refractory metal is incorporated in the fuel element between the cladding and the nuclear fuel to inhibit mechanical interaction between the nuclear fuel and the cladding, to isolate fission products and nuclear fuel impurities from contacting the cladding, and to improve the axial thermal peaking gradient along the length of the fuel rod. The metal liner can be in the form of a tube or hollow cylindrical column, a foil of single or multiple layers in the shape of a hollow cylindrical column, or a coating on the internal surface of the cladding. Preferred refractory metal materials are molybdenum, tungsten, rhenium, niobium and alloys of the foregoing metals

Nuclear fuel element

International Nuclear Information System (INIS)

Thompson, J.R.; Rowland, T.C.

1976-01-01

A nuclear fuel element for use in the core of a nuclear reactor is disclosed. A heat conducting, fission product retaining metal liner of a refractory metal is incorporated in the fuel element between the cladding and the nuclear fuel to inhibit mechanical interaction between the nuclear fuel and the cladding, to isolate fission products and nuclear fuel impurities from contacting the cladding and to improve the axial thermal peaking gradient along the length of the fuel rod. The metal liner can be in the form of a tube or hollow cylindrical column, a foil of single or multiple layers in the shape of a hollow cylindrical column, or a coating on the internal surface of the cladding. Preferred refractory metal materials are molybdenum, tungsten, rhenium, niobium and alloys of the foregoing metals

Export financing of nuclear power plants - banks experience

International Nuclear Information System (INIS)

Loeber

1976-01-01

Export financing of a nuclear power plant to be exported from Germany, is, in principle, provided by German commercial banks and KfW (Kreditanstalt fuer Wiederaufbau). As a rule, 50 per cent of the financing of maturities falling due under the export portion of the loan will be taken over by a banking syndicate of approximately 25 member banks, and the remaining 50 per cent would be provided by KfW. KfW and the commercial banks must grant their loans at the respective money market conditions. The banks' and KfW's loans will normally be disbursed pro rata delivery. (HP) [de

Nuclear Fuel Leasing, Recycling and proliferation: Modeling a Global View

International Nuclear Information System (INIS)

Crozat, M P; Choi, J; Reis, V H; Hill, R

2004-01-01

On February 11, 2004, U.S. President George W. Bush, in a speech to the National Defense University stated: ''The world must create a safe, orderly system to field civilian nuclear plants without adding to the danger of weapons proliferation. The world's leading nuclear exporters should ensure that states have reliable access at reasonable cost to fuel for civilian reactors, so long as those states renounce enrichment and reprocessing. Enrichment and reprocessing are not necessary for nations seeking to harness nuclear energy for peaceful purposes.'' This concept would require nations to choose one of two paths for civilian nuclear development: those that only have reactors and those that contain one or more elements of the nuclear fuel cycle, including recycling. ''Fuel cycle'' states would enrich uranium, manufacture and lease fuel to ''reactor'' states and receive the reactor states' spent fuel. All parties would accede to stringent security and safeguard standards, embedded within a newly invigorated international regime. Reactor states would be relieved of the financial, environmental (and political) burden of enriching and manufacturing fuel and dealing with spent fuel. Fuel cycle states would potentially earn money on leasing the fuel and perhaps on sales of reactors to the reactor states. Such a leasing concept is especially interesting in scenarios which envision growth in nuclear power, and an important consideration for such a nuclear growth regime is the role of recycling of civilian spent fuel. Recycling holds promise for improved management of spent fuel and efficient utilization of resources, but continues to raise the specter of a world with uncontrolled nuclear weapons proliferation. If done effectively, a fuel-leasing concept could help create a political and economic foundation for significant growth of clean, carbon-free nuclear power while providing a mechanism for significant international cooperation to reduce proliferation concern. This

Nuclear-fuel-cycle education: Module 1. Nuclear fuel cycle overview

International Nuclear Information System (INIS)

Eckhoff, N.D.

1981-07-01

This educational module is an overview of the nuclear-fule-cycle. The overview covers nuclear energy resources, the present and future US nuclear industry, the industry view of nuclear power, the International Nuclear Fuel Cycle Evaluation program, the Union of Concerned Scientists view of the nuclear-fuel-cycle, an analysis of this viewpoint, resource requirements for a model light water reactor, and world nuclear power considerations

Nuclear Import and Export of the Thyroid Hormone Receptor.

Science.gov (United States)

Zhang, Jibo; Roggero, Vincent R; Allison, Lizabeth A

2018-01-01

The thyroid hormone receptors, TRα1 and TRβ1, are members of the nuclear receptor superfamily that forms one of the most abundant classes of transcription factors in multicellular organisms. Although primarily localized to the nucleus, TRα1 and TRβ1 shuttle rapidly between the nucleus and cytoplasm. The fine balance between nuclear import and export of TRs has emerged as a critical control point for modulating thyroid hormone-responsive gene expression. Mutagenesis studies have defined two nuclear localization signal (NLS) motifs that direct nuclear import of TRα1: NLS-1 in the hinge domain and NLS-2 in the N-terminal A/B domain. Three nuclear export signal (NES) motifs reside in the ligand-binding domain. A combined approach of shRNA-mediated knockdown and coimmunoprecipitation assays revealed that nuclear entry of TRα1 is facilitated by importin 7, likely through interactions with NLS-2, and importin β1 and the adapter importin α1 interacting with both NLS-1 and NLS-2. Interestingly, TRβ1 lacks NLS-2 and nuclear import depends solely on the importin α1/β1 heterodimer. Heterokaryon and fluorescence recovery after photobleaching shuttling assays identified multiple exportins that play a role in nuclear export of TRα1, including CRM1 (exportin 1), and exportins 4, 5, and 7. Even single amino acid changes in TRs dramatically alter their intracellular distribution patterns. We conclude that mutations within NLS and NES motifs affect nuclear shuttling activity, and propose that TR mislocalization contributes to the development of some types of cancer and Resistance to Thyroid Hormone syndrome. © 2018 Elsevier Inc. All rights reserved.

The National Implementation of Nuclear Export Controls: Developing a Best Practices Model

Energy Technology Data Exchange (ETDEWEB)

Viski, Andrea [European University Institute, Department of Law, Badia Fiesolana, S.Domenico di Fiesole, Firenze (Italy)

2011-12-15

The nuclear renaissance promises significant benefits to the international community, but also raises security challenges, particularly relating to the trade of nuclear materials and equipment. The objective of this paper is to examine how supply-side non-proliferation efforts can be strengthened by developing a best practices model for national nuclear export control implementation. In order to achieve this goal, nuclear export control measures identified by the 1540 Committee will be used as a framework from which a best practices model can be formed. Such a model concentrates specifically on national legislation and enforcement measures delineated by the Committee in order to bring countries in accordance with international law. Developing a best practices model seeks to deliver an ideal process for national export control law actualization in order to encourage the peaceful development of nuclear energy and develop the infrastructure and framework for precluding nuclear proliferation.

Examining the intersection between splicing, nuclear export and small RNA pathways.

Science.gov (United States)

Nabih, Amena; Sobotka, Julia A; Wu, Monica Z; Wedeles, Christopher J; Claycomb, Julie M

2017-11-01

Nuclear Argonaute/small RNA pathways in a variety of eukaryotic species are generally known to regulate gene expression via chromatin modulation and transcription attenuation in a process known as transcriptional gene silencing (TGS). However, recent data, including genetic screens, phylogenetic profiling, and molecular mechanistic studies, also point to a novel and emerging intersection between the splicing and nuclear export machinery with nuclear Argonaute/small RNA pathways in many organisms. In this review, we summarize the field's current understanding regarding the relationship between splicing, export and small RNA pathways, and consider the biological implications for coordinated regulation of transcripts by these pathways. We also address the importance and available approaches for understanding the RNA regulatory logic generated by the intersection of these particular pathways in the context of synthetic biology. The interactions between various eukaryotic RNA regulatory pathways, particularly splicing, nuclear export and small RNA pathways provide a type of combinatorial code that informs the identity ("self" versus "non-self") and dictates the fate of each transcript in a cell. Although the molecular mechanisms for how splicing and nuclear export impact small RNA pathways are not entirely clear at this early stage, the links between these pathways are widespread across eukaryotic phyla. The link between splicing, nuclear export, and small RNA pathways is emerging and establishes a new frontier for understanding the combinatorial logic of gene regulation across species that could someday be harnessed for therapeutic, biotechnology and agricultural applications. This article is part of a Special Issue entitled "Biochemistry of Synthetic Biology - Recent Developments" Guest Editor: Dr. Ilka Heinemann and Dr. Patrick O'Donoghue. Copyright © 2017 Elsevier B.V. All rights reserved.

Strategy of nuclear power in Korea, non-nuclear-weapon state and peaceful use of nuclear power

International Nuclear Information System (INIS)

Nagasaki, Takao

2005-01-01

The nuclear power plant started at Kori in Korea in April, 1978. Korea has carried out development of nuclear power as a national policy. The present capacity of nuclear power plants takes the sixes place in the world. It supplies 42% total power generation. The present state of nuclear power plant, nuclear fuel cycle facility, strategy of domestic production of nuclear power generation, development of next generation reactor and SMART, strategy of export in corporation with industry, government and research organization, export of nuclear power generation in Japan, nuclear power improvement project with Japan, Korea and Asia, development of nuclear power system with nuclear diffusion resistance, Hybrid Power Extraction Reactor System, radioactive waste management and construction of joint management and treatment system of spent fuel in Asia are stated. (S.Y.)

Promising SINEs for embargoing nuclear-cytoplasmic export as an anticancer strategy.

Science.gov (United States)

Tan, David S P; Bedard, Philippe L; Kuruvilla, John; Siu, Lillian L; Razak, Albiruni R Abdul

2014-05-01

In cancer cells, the nuclear-cytoplasmic transport machinery is frequently disrupted, resulting in mislocalization and loss of function for many key regulatory proteins. In this review, the mechanisms by which tumor cells co-opt the nuclear transport machinery to facilitate carcinogenesis, cell survival, drug resistance, and tumor progression will be elucidated, with a particular focus on the role of the nuclear-cytoplasmic export protein. The recent development of a new generation of selective inhibitors of nuclear export (XPO1 antagonists) and how these novel anticancer drugs may bring us closer to the implementation of this therapeutic strategy in the clinic will be discussed.

Upgrading the safety assessment of exported nuclear power plants

International Nuclear Information System (INIS)

Rosen, M.

1978-01-01

An examination of the safety aspects of exported nuclear power plants demonstrates that additional and somewhat special considerations exist for these plants, and thus that some new approaches may be required to insure their safety. In view of the generally small regulatory staffs of importing countries, suggestions are given for measures which should be taken by the various organizations involved in the export and import of nuclear power facilities to raise the level of the very essential safety assessment. These include the upgrading of the 'export edition' of the traditionally supplied safety documentation by use of a Supplementary Information Report, written specifically for the needs of a smaller and/or less technically qualified staff, which highlights the differences that exist between the facility to be constructed and the supposedly similar reference plant of the supplier country; by improvement of supporting safety documentation to allow for adequate understanding of significant safety parameters; and by attention to the needs of smaller countries in the critical Operating Regulations (Technical Specifications for Operation). Consideration is also given to upgrading the regulatory effort and to the obligations of principal organizations involved with exported nuclear plants, including national and international, for insuring the importing countries' technical readiness and the adequacy of the regulatory effort. Special attention is directed towards the project contract as a means of implementing programmes to achieve these goals. (author)

Decision support for selecting exportable nuclear technology using the analytic hierarchy process: A Korean case

International Nuclear Information System (INIS)

Lee, Deok Joo; Hwang, Jooho

2010-01-01

The Korean government plans to increase strategically focused R and D investment in some promising nuclear technology areas to create export opportunities of technology in a global nuclear market. The purpose of this paper is to present a decision support process for selecting promising nuclear technology with the perspective of exportability by using the AHP based on extensive data gathered from nuclear experts in Korea. In this study, the decision criteria for evaluating the export competitiveness of nuclear technologies were determined, and a hierarchical structure for the decision-making process was systematically developed. Subsequently relative weights of decision criteria were derived using AHP methodology and the export competitiveness of nuclear technology alternatives was quantified to prioritize them. We discuss the implications of our results with a viewpoint toward national nuclear technology policy.

Nuclear export policy and regulation for non-proliferation: Federal Republic of Germany

International Nuclear Information System (INIS)

Boulanger, Werner.

1978-01-01

The nuclear export policy of the Federal Republic of Germany complies with the principle of non-proliferation of nuclear weapons. Already in 1967 the Federal Government stated in a Peace Note that no export was authorised to countries (outside Euratom) which did not comply with the IAEA Safeguards. In the bilateral agreement the Federal Republic signed with Brasil in 1975, emphasis was put on international safeguards and the control exercised on exported materials to avoid any diversion for military purposes. (NEA) [fr

High-Resolution Imaging Reveals New Features of Nuclear Export of mRNA through the Nuclear Pore Complexes

Directory of Open Access Journals (Sweden)

Joseph M. Kelich

2014-08-01

Full Text Available The nuclear envelope (NE of eukaryotic cells provides a physical barrier for messenger RNA (mRNA and the associated proteins (mRNPs traveling from sites of transcription in the nucleus to locations of translation processing in the cytoplasm. Nuclear pore complexes (NPCs embedded in the NE serve as a dominant gateway for nuclear export of mRNA. However, the fundamental characterization of export dynamics of mRNPs through the NPC has been hindered by several technical limits. First, the size of NPC that is barely below the diffraction limit of conventional light microscopy requires a super-resolution microscopy imaging approach. Next, the fast transit of mRNPs through the NPC further demands a high temporal resolution by the imaging approach. Finally, the inherent three-dimensional (3D movements of mRNPs through the NPC demand the method to provide a 3D mapping of both transport kinetics and transport pathways of mRNPs. This review will highlight the recently developed super-resolution imaging techniques advanced from 1D to 3D for nuclear export of mRNPs and summarize the new features in the dynamic nuclear export process of mRNPs revealed from these technical advances.

Nuclear fuel element

International Nuclear Information System (INIS)

Yamamoto, Seigoro.

1994-01-01

Ultrafine particles of a thermal neutron absorber showing ultraplasticity is dispersed in oxide ceramic fuels by more than 1% to 10% or lower. The ultrafine particles of the thermal neutron absorber showing ultrafine plasticity is selected from any one of ZrGd, HfEu, HfY, HfGd, ZrEu, and ZrY. The thermal neutron absorber is converted into ultrafine particles and solid-solubilized in a nuclear fuel pellet, so that the dispersion thereof into nuclear fuels is made uniform and an absorbing performance of the thermal neutrons is also made uniform. Moreover, the characteristics thereof, for example, physical properties such as expansion coefficient and thermal conductivity of the nuclear fuels are also improved. The neutron absorber, such as ZrGd or the like, can provide plasticity of nuclear fuels, if it is mixed into the nuclear fuels for showing the plasticity. The nuclear fuel pellets are deformed like an hour glass as burning, but, since the end portion thereof is deformed plastically within a range of a repulsive force of the cladding tube, there is no worry of damaging a portion of the cladding tube. (N.H.)

Nuclear safety aspects of exported replicate nuclear power plants and associated problems

International Nuclear Information System (INIS)

Kern, H.G.

1978-01-01

The standardization of the export nuclear power plant is being pursued with the concept of replication. This concept entails using another exported Nuclear Power Plant (NPP) as the base design and adapting it to a new site. The general ground rule applied to this concept is upgrading the design where necessary and duplicating the design where it is superior. Such continuous improvement will result in a standard export NPP that incorporates design features which will make it essentially acceptable for any suitable site. The advantages of replication are, therefore, boundless. However, the replication mode requires superior design control by the engineer to assure that only improvements alter the base design. With this concept, the replicating engineer is essentially assigned the responsiblity of safeguarding the standard export plant design. He is delegated the task of filtering the design such that only the conservative aspects prevail. Tight control of design changes via properly administered procedures is necessary to assure that no unforeseen compromises are made in designs which have already achieved optimization. Techniques to accomplish successful replication include, among others, the use of PCNs, system cognizant engineers, design verfication review, and the participation of all engineering disciplines in the development of the project schedule. (author)

The Bacterial Flagellar Type III Export Gate Complex Is a Dual Fuel Engine That Can Use Both H+ and Na+ for Flagellar Protein Export.

Directory of Open Access Journals (Sweden)

Tohru Minamino

2016-03-01

Full Text Available The bacterial flagellar type III export apparatus utilizes ATP and proton motive force (PMF to transport flagellar proteins to the distal end of the growing flagellar structure for self-assembly. The transmembrane export gate complex is a H+-protein antiporter, of which activity is greatly augmented by an associated cytoplasmic ATPase complex. Here, we report that the export gate complex can use sodium motive force (SMF in addition to PMF across the cytoplasmic membrane to drive protein export. Protein export was considerably reduced in the absence of the ATPase complex and a pH gradient across the membrane, but Na+ increased it dramatically. Phenamil, a blocker of Na+ translocation, inhibited protein export. Overexpression of FlhA increased the intracellular Na+ concentration in the presence of 100 mM NaCl but not in its absence, suggesting that FlhA acts as a Na+ channel. In wild-type cells, however, neither Na+ nor phenamil affected protein export, indicating that the Na+ channel activity of FlhA is suppressed by the ATPase complex. We propose that the export gate by itself is a dual fuel engine that uses both PMF and SMF for protein export and that the ATPase complex switches this dual fuel engine into a PMF-driven export machinery to become much more robust against environmental changes in external pH and Na+ concentration.

The Bacterial Flagellar Type III Export Gate Complex Is a Dual Fuel Engine That Can Use Both H+ and Na+ for Flagellar Protein Export.

Science.gov (United States)

Minamino, Tohru; Morimoto, Yusuke V; Hara, Noritaka; Aldridge, Phillip D; Namba, Keiichi

2016-03-01

The bacterial flagellar type III export apparatus utilizes ATP and proton motive force (PMF) to transport flagellar proteins to the distal end of the growing flagellar structure for self-assembly. The transmembrane export gate complex is a H+-protein antiporter, of which activity is greatly augmented by an associated cytoplasmic ATPase complex. Here, we report that the export gate complex can use sodium motive force (SMF) in addition to PMF across the cytoplasmic membrane to drive protein export. Protein export was considerably reduced in the absence of the ATPase complex and a pH gradient across the membrane, but Na+ increased it dramatically. Phenamil, a blocker of Na+ translocation, inhibited protein export. Overexpression of FlhA increased the intracellular Na+ concentration in the presence of 100 mM NaCl but not in its absence, suggesting that FlhA acts as a Na+ channel. In wild-type cells, however, neither Na+ nor phenamil affected protein export, indicating that the Na+ channel activity of FlhA is suppressed by the ATPase complex. We propose that the export gate by itself is a dual fuel engine that uses both PMF and SMF for protein export and that the ATPase complex switches this dual fuel engine into a PMF-driven export machinery to become much more robust against environmental changes in external pH and Na+ concentration.

Importance and topical problems of the industry of the nuclear fuel cycle in the Federal Republic of Germany

International Nuclear Information System (INIS)

Warrikoff, A.

1987-01-01

32 companies belong to the industrial association 'Kernbrennstoffkreislauf e.V.'. They do business in the nuclear fuel cycle in the Federal Republic of Germany. This field comprises the different forms of dealing with nuclear fuels and the materials from which they are made, including the radioactive wastes resulting from the use of nuclear fuels, with the exception of the handling of such materials in nuclear power plants. Some 5000 persons - subcontractors not counted - are employed in this branch of industry. Turnover amounts to about 2 billion Deutsch Marks yearly. But it is a branch of industry that is important beyond the figures mentioned. Its existence constitutes the precondition for building, operating, and exporting nuclear power plants. This paper is concerned particularly with some topical political problems. (orig./UA) [de

Nuclear Fuel Reprocessing

International Nuclear Information System (INIS)

Simpson, Michael F.; Law, Jack D.

2010-01-01

This is a submission for the Encyclopedia of Sustainable Technology on the subject of Reprocessing Spent Nuclear Fuel. Nuclear reprocessing is the chemical treatment of spent fuel involving separation of its various constituents. Principally, it is used to recover useful actinides from the spent fuel. Radioactive waste that cannot be re-used is separated into streams for consolidation into waste forms. The first known application of nuclear reprocessing was within the Manhattan Project to recover material for nuclear weapons. Currently, reprocessing has a peaceful application in the nuclear fuel cycle. A variety of chemical methods have been proposed and demonstrated for reprocessing of nuclear fuel. The two most widely investigated and implemented methods are generally referred to as aqueous reprocessing and pyroprocessing. Each of these technologies is described in detail in Section 3 with numerous references to published articles. Reprocessing of nuclear fuel as part of a fuel cycle can be used both to recover fissionable actinides and to stabilize radioactive fission products into durable waste forms. It can also be used as part of a breeder reactor fuel cycle that could result in a 14-fold or higher increase in energy utilization per unit of natural uranium. Reprocessing can also impact the need for geologic repositories for spent fuel. The volume of waste that needs to be sent to such a repository can be reduced by first subjecting the spent fuel to reprocessing. The extent to which volume reduction can occur is currently under study by the United States Department of Energy via research at various national laboratories and universities. Reprocessing can also separate fissile and non-fissile radioactive elements for transmutation.

The nuclear export policy of the Reagan administration

International Nuclear Information System (INIS)

Pilat, J.F.; Donnelly, W.H.

1983-01-01

tThe Reagan Administration maintains the Carter Administration's objective of non-proliferation of nuclear weapons as being fundamental to US nuclear export policy. However, it sees the USA as having another important role to play in influencing the use of nuclear power and the trading of related goods and technologies in other countries. While the Administration believes its policies will prove beneficial to the USA, there is concern that trade considerations are being given priority over preventing the proliferation of nuclear weapons. (author)

O. Nuclear energy in a food exporting country

International Nuclear Information System (INIS)

1976-01-01

This report attempts to estimate the affect on agricultural exports from New Zealand which might result from the operation of nuclear power. By far the most serious of these would result from an accidental release of radioactive material, and the likely affects of such releases are considered both in the first year after an accident and in the future. Previous assessments of this type have concentrated attention on property damage and on the health hazards which might result to consumers of contaminated food in the first year or two after a release. In this report the emphasis is on exported foods to which different criteria might apply, and some very approximate estimates are made of long-term implications. To a large extent these can be described only as speculations, but they have some value as a guide. No analgous report has been found in the open literature from other countries, and this particularly includes Denmark which has much in common with New Zealand in this regard. The possible effect of routine operation of nuclear power on food exports is also briefly considered

Nuclear fuel elements

International Nuclear Information System (INIS)

Nakai, Keiichi

1983-01-01

Purpose: To decrease the tensile stresses resulted in a fuel can as well as prevent decladding of fuel pellets into the bore holes by decreasing the inner pressure within the nuclear fuel element. Constitution: A fuel can is filled with hollow fuel pellets, inserted with a spring for retaining the hollow fuel pellets with an appropriate force and, thereafter, closely sealed at the both ends with end plugs. A cylindrical body is disposed into the bore holes of the hollow fuel pellets. Since initial sealing gases and/or gaseous nuclear fission products can thus be excluded from the bore holes where the temperature is at the highest level, the inner pressure of the nuclear fuel element can be reduced to decrease the tensile strength resulted to the fuel can. Furthermore, decladding of fuel pellets into the bore holes can be prevented. (Moriyama, K.)

Nuclear fuels and development of nuclear fuel elements

International Nuclear Information System (INIS)

Sundaram, C.V.; Mannan, S.L.

1989-01-01

Safe, reliable and economic operation of nuclear fission reactors, the source of nuclear power at present, requires judicious choice, careful preparation and specialised fabrication procedures for fuels and fuel element structural materials. These aspects of nuclear fuels (uranium, plutonium and their oxides and carbides), fuel element technology and structural materials (aluminium, zircaloy, stainless steel etc.) are discussed with particular reference to research and power reactors in India, e.g. the DHRUVA research reactor at BARC, Trombay, the pressurised heavy water reactors (PHWR) at Rajasthan and Kalpakkam, and the Fast Breeder Test Reactor (FBTR) at Kalpakkam. Other reactors like the gas-cooled reactors operating in UK are also mentioned. Because of the limited uranium resources, India has opted for a three-stage nuclear power programme aimed at the ultimate utilization of her abundant thorium resources. The first phase consists of natural uranium dioxide-fuelled, heavy water-moderated and cooled PHWR. The second phase was initiated with the attainment of criticality in the FBTR at Kalpakkam. Fast Breeder Reactors (FBR) utilize the plutonium and uranium by-products of phase 1. Moreover, FBR can convert thorium into fissile 233 U. They produce more fuel than is consumed - hence, the name breeders. The fuel parameters of some of the operating or proposed fast reactors in the world are compared. FBTR is unique in the choice of mixed carbides of plutonium and uranium as fuel. Factors affecting the fuel element performance and life in various reactors e.g. hydriding of zircaloys, fuel pellet-cladding interaction etc. in PHWR and void swelling; irradiation creep and helium embrittlement of fuel element structural materials in FBR are discussed along with measures to overcome some of these problems. (author). 15 refs., 9 tabs., 23 figs

Nuclear fuel assembly

International Nuclear Information System (INIS)

Anthony, A.J.

1980-01-01

A bimetallic spacer means is cooperatively associated with a nuclear fuel assembly and operative to resist the occurrence of in-reactor bowing of the nuclear fuel assembly. The bimetallic spacer means in one embodiment of the invention includes a space grid formed, at least principally, of zircaloy to the external surface of which are attached a plurality of stainless steel strips. In another embodiment the strips are attached to fuel pins. In each of the embodiments, the stainless steel strips during power production expand outwardly to a greater extent than do the members to which the stainless steel strips are attached, thereby forming stiff springs which abut against like bimetallic spacer means with which the other nuclear fuel assemblies are provided in a given nuclear reactor core to thus prevent the occurrence of in-reactor bowing of the nuclear fuel assemblies. (author)

Managing the Nuclear Fuel Cycle, The Big Picture

International Nuclear Information System (INIS)

Carlsen, Brett W.

2010-01-01

The nuclear industry, at least in the United States, has failed to deliver on its promise of cheap, abundant energy. After pioneering the science and application and becoming a primary exporter of nuclear technologies, domestic use of nuclear power fell out-of-favor with the public and has been relatively stagnant for several decades. Recently, renewed interest has generated optimism and talk of a nuclear renaissance characterized by a new generation of safe, clean nuclear plants in this country. But, as illustrated by recent policy shifts regarding closure of the fuel cycle and geologic disposal of high-level radioactive wastes, significant hurdles have yet to be overcome. Using the principles of system dynamics, this paper will take a holistic look at the nuclear industry and the interactions between the key players to explore both the intended and unintended consequences of efforts to address the issues that have impeded the growth of the industry and also to illustrate aspects which must be effectively addressed if the renaissance of our industry is to be achieved and sustained.

Managing the Nuclear Fuel Cycle, The Big Picture

Energy Technology Data Exchange (ETDEWEB)

Brett W Carlsen

2010-07-01

The nuclear industry, at least in the United States, has failed to deliver on its promise of cheap, abundant energy. After pioneering the science and application and becoming a primary exporter of nuclear technologies, domestic use of nuclear power fell out-of-favor with the public and has been relatively stagnant for several decades. Recently, renewed interest has generated optimism and talk of a nuclear renaissance characterized by a new generation of safe, clean nuclear plants in this country. But, as illustrated by recent policy shifts regarding closure of the fuel cycle and geologic disposal of high-level radioactive wastes, significant hurdles have yet to be overcome. Using the principles of system dynamics, this paper will take a holistic look at the nuclear industry and the interactions between the key players to explore both the intended and unintended consequences of efforts to address the issues that have impeded the growth of the industry and also to illustrate aspects which must be effectively addressed if the renaissance of our industry is to be achieved and sustained.

10 CFR 110.26 - General license for the export of nuclear reactor components.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false General license for the export of nuclear reactor components. 110.26 Section 110.26 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF... Denmark Finland France Germany Greece Indonesia Ireland Italy Japan Latvia Lithuania Luxembourg...

Nuclear power and the nuclear fuel cycle

Energy Technology Data Exchange (ETDEWEB)

NONE

1976-07-01

The IAEA is organizing a major conference on nuclear power and the nuclear fuel cycle, which is to be held from 2 to 13 May 1977 in Salzburg, Austria. The programme for the conference was published in the preceding issue of the IAEA Bulletin (Vol.18, No. 3/4). Topics to be covered at the conference include: world energy supply and demand, supply of nuclear fuel and fuel cycle services, radioactivity management (including transport), nuclear safety, public acceptance of nuclear power, safeguarding of nuclear materials, and nuclear power prospects in developing countries. The articles in the section that follows are intended to serve as an introduction to the topics to be discussed at the Salzburg Conference. They deal with the demand for uranium and nuclear fuel cycle services, uranium supplies, a computer simulation of regional fuel cycle centres, nuclear safety codes, management of radioactive wastes, and a pioneering research project on factors that determine public attitudes toward nuclear power. It is planned to present additional background articles, including a review of the world nuclear fuel reprocessing situation and developments in the uranium enrichment industry, in future issues of the Bulletin. (author)

Nuclear power generation and nuclear fuel

International Nuclear Information System (INIS)

Okajima, Yasujiro

1985-01-01

As of June 30, 1984, in 25 countries, 311 nuclear power plants of about 209 million kW were in operation. In Japan, 27 plants of about 19 million kW were in operation, and Japan ranks fourth in the world. The present state of nuclear power generation and nuclear fuel cycle is explained. The total uranium resources in the free world which can be mined at the cost below $130/kgU are about 3.67 million t, and it was estimated that the demand up to about 2015 would be able to be met. But it is considered also that the demand and supply of uranium in the world may become tight at the end of 1980s. The supply of uranium to Japan is ensured up to about 1995, and the yearly supply of 3000 st U 3 O 8 is expected in the latter half of 1990s. The refining, conversion and enrichment of uranium are described. In Japan, a pilot enrichment plant consisting of 7000 centrifuges has the capacity of about 50 t SWU/year. UO 2 fuel assemblies for LWRs, the working of Zircaloy, the fabrication of fuel assemblies, the quality assurance of nuclear fuel, the behavior of UO 2 fuel, the grading-up of LWRs and nuclear fuel, and the nuclear fuel business in Japan are reported. The reprocessing of spent fuel and plutonium fuel are described. (Kako, I.)

Role of Non-Government Organizations in strengthening Kazakstan nuclear export control

International Nuclear Information System (INIS)

Tazhibaeva, L.; Prokhodtseva, T.

2002-01-01

Non-governmental organizations (NGO) are the structures that were born by the time, the time when deep changes in our society led us to new trends in the all spheres of society development, to new decisions and, as a consequence, to new structural findings that where able to govern, to support and put into reality the new ideas the could not be inserted in the structure assemblies of the former society. All non-governmental organizations in Kazakhstan are younger than ten years old, but they already could be considered highly experienced, for intensity of their activity is rather high. The main advantages of NGOs are flexibility and independent source of ideas, basic data and policy assessment. There are several non-government organizations that are working in the field of non-proliferation and export control. Kazakhstan Nuclear Technology Safety Center (NTSC) is among them. Non-proliferation and export control is only a small part of activity that NTSC is involved in. Non-governmental organizations could be of several types: NGOs that are affiliated with university or institute, independent associations, quasi-governmental structures and various foundations. NTSC complementing efforts of Kazakhstan Atomic Energy Committee (KAEC) in the field of non-proliferation and export control. The activity of NTSC in the field of non-proliferation includes: Holding conferences, seminars and workshops; Creating databases and reports; Develop proposal for legislation; Provide specialized training; Analyze data. NTSC is involved in a number of projects devoted to non-proliferation and export control. The following projects are supported by the US Department of Energy cooperation program on nuclear export controls for Russia and the Newly Independent States: System to review Kazakhstan exports (STROKE); Computerization of historical licensing data; Export control reference materials for Kazakhstan organizations; Additional Protocol. STROKE is a technical analysis database for

Sharing the load: Mex67-Mtr2 cofunctions with Los1 in primary tRNA nuclear export.

Science.gov (United States)

Chatterjee, Kunal; Majumder, Shubhra; Wan, Yao; Shah, Vijay; Wu, Jingyan; Huang, Hsiao-Yun; Hopper, Anita K

2017-11-01

Eukaryotic transfer RNAs (tRNAs) are exported from the nucleus, their site of synthesis, to the cytoplasm, their site of function for protein synthesis. The evolutionarily conserved β-importin family member Los1 (Exportin-t) has been the only exporter known to execute nuclear export of newly transcribed intron-containing pre-tRNAs. Interestingly, LOS1 is unessential in all tested organisms. As tRNA nuclear export is essential, we previously interrogated the budding yeast proteome to identify candidates that function in tRNA nuclear export. Here, we provide molecular, genetic, cytological, and biochemical evidence that the Mex67-Mtr2 (TAP-p15) heterodimer, best characterized for its essential role in mRNA nuclear export, cofunctions with Los1 in tRNA nuclear export. Inactivation of Mex67 or Mtr2 leads to rapid accumulation of end-matured unspliced tRNAs in the nucleus. Remarkably, merely fivefold overexpression of Mex67-Mtr2 can substitute for Los1 in los1 Δ cells. Moreover, in vivo coimmunoprecipitation assays with tagged Mex67 document that the Mex67 binds tRNAs. Our data also show that tRNA exporters surprisingly exhibit differential tRNA substrate preferences. The existence of multiple tRNA exporters, each with different tRNA preferences, may indicate that the proteome can be regulated by tRNA nuclear export. Thus, our data show that Mex67-Mtr2 functions in primary nuclear export for a subset of yeast tRNAs. © 2017 Chatterjee et al.; Published by Cold Spring Harbor Laboratory Press.

Russian nuclear survey

International Nuclear Information System (INIS)

2002-07-01

This document gives a broad overview of the organization of nuclear activities in the Russian federation: Minatom activities, nuclear park and availability (reactors, performances, export activity), perspectives of development (improvement of safety, age of reactors, new realizations); fuel cycle (uranium production, conversion and enrichment, fuel fabrication, spent fuel reprocessing); wastes management (storage and disposal sites); R and D activities (organizations) and nuclear safety authority. (J.S.)

Role of ion chromatograph in nuclear fuel fabrication process at Nuclear Fuel Complex

International Nuclear Information System (INIS)

Balaji Rao, Y.; Prasada Rao, G.; Prahlad, B.; Saibaba, N.

2012-01-01

The present paper discusses the different applications of ion chromatography followed in nuclear fuel fabrication process at Nuclear Fuel Complex. Some more applications of IC for characterization of nuclear materials and which are at different stages of method development at Control Laboratory, Nuclear Fuel Complex are also highlighted

Three-Dimensional Mapping of mRNA Export through the Nuclear Pore Complex

Directory of Open Access Journals (Sweden)

Steven J. Schnell

2014-11-01

Full Text Available The locations of transcription and translation of mRNA in eukaryotic cells are spatially separated by the nuclear envelope (NE. Plenty of nuclear pore complexes (NPCs embedded in the NE function as the major gateway for the export of transcribed mRNAs from the nucleus to the cytoplasm. Whereas the NPC, perhaps one of the largest protein complexes, provides a relatively large channel for macromolecules to selectively pass through it in inherently three-dimensional (3D movements, this channel is nonetheless below the diffraction limit of conventional light microscopy. A full understanding of the mRNA export mechanism urgently requires real-time mapping of the 3D dynamics of mRNA in the NPC of live cells with innovative imaging techniques breaking the diffraction limit of conventional light microscopy. Recently, super-resolution fluorescence microscopy and single-particle tracking (SPT techniques have been applied to the study of nuclear export of mRNA in live cells. In this review, we emphasize the necessity of 3D mapping techniques in the study of mRNA export, briefly summarize the feasibility of current 3D imaging approaches, and highlight the new features of mRNA nuclear export elucidated with a newly developed 3D imaging approach combining SPT-based super-resolution imaging and 2D-to-3D deconvolution algorithms.

Nuclear fuel cycle system analysis

International Nuclear Information System (INIS)

Ko, W. I.; Kwon, E. H.; Kim, S. G.; Park, B. H.; Song, K. C.; Song, D. Y.; Lee, H. H.; Chang, H. L.; Jeong, C. J.

2012-04-01

The nuclear fuel cycle system analysis method has been designed and established for an integrated nuclear fuel cycle system assessment by analyzing various methodologies. The economics, PR(Proliferation Resistance) and environmental impact evaluation of the fuel cycle system were performed using improved DB, and finally the best fuel cycle option which is applicable in Korea was derived. In addition, this research is helped to increase the national credibility and transparency for PR with developing and fulfilling PR enhancement program. The detailed contents of the work are as follows: 1)Establish and improve the DB for nuclear fuel cycle system analysis 2)Development of the analysis model for nuclear fuel cycle 3)Preliminary study for nuclear fuel cycle analysis 4)Development of overall evaluation model of nuclear fuel cycle system 5)Overall evaluation of nuclear fuel cycle system 6)Evaluate the PR for nuclear fuel cycle system and derive the enhancement method 7)Derive and fulfill of nuclear transparency enhancement method The optimum fuel cycle option which is economical and applicable to domestic situation was derived in this research. It would be a basis for establishment of the long-term strategy for nuclear fuel cycle. This work contributes for guaranteeing the technical, economical validity of the optimal fuel cycle option. Deriving and fulfillment of the method for enhancing nuclear transparency will also contribute to renewing the ROK-U.S Atomic Energy Agreement in 2014

Nuclear fuel lease accounting

International Nuclear Information System (INIS)

Danielson, A.H.

1986-01-01

The subject of nuclear fuel lease accounting is a controversial one that has received much attention over the years. This has occurred during a period when increasing numbers of utilities, seeking alternatives to traditional financing methods, have turned to leasing their nuclear fuel inventories. The purpose of this paper is to examine the current accounting treatment of nuclear fuel leases as prescribed by the Financial Accounting Standards Board (FASB) and the Federal Energy Regulatory Commission's (FERC's) Uniform System of Accounts. Cost accounting for leased nuclear fuel during the fuel cycle is also discussed

Boosting nuclear fuels

International Nuclear Information System (INIS)

Demarthon, F.; Donnars, O.; Dupuy-Maury, F.

2002-01-01

This dossier gives a broad overview of the present day status of the nuclear fuel cycle in France: 1 - the revival of nuclear power as a solution to the global warming and to the increase of worldwide energy needs; 2 - the security of uranium supplies thanks to the reuse of weapon grade highly enriched uranium; 3 - the fabrication of nuclear fuels from the mining extraction to the enrichment processes, the fabrication of fuel pellets and the assembly of fuel rods; 4 - the new composition of present day fuels (UO x and chromium-doped pellets); 5 - the consumption of plutonium stocks and the Corail and Apa fuel assemblies for the reduction of plutonium stocks and the preservation of uranium resources. (J.S.)

International arrangements for nuclear-fuel-cycle facilities: the politics of the problem

International Nuclear Information System (INIS)

Epstein, W.

1977-01-01

Thirty years after the Three-Power Declaration on November 5, 1945, promising effective safeguards on the information exchange on atomic energy, many nations are selling and transferring nuclear materials, equipment, and technology without these ''effective enforceable safeguards.'' Even though there is no actual commercial need to reprocess spent fuel into Pu, France and West Germany are planning to sell reprocessing plants to non-NPT countries. The erosion of faith in and the weakening of the NPT are pointed out. The Canadian decision not to resume nuclear aid to India is commended. The question of how effective and enforceable the international (IAEA/NPT) safeguards are, is addressed. The weaknesses of the London Suppliers' Club position on safeguards are pointed out. Multinational fuel cycle centers would not much help to contain the risks of nuclear proliferation. Additional measures needed for really effective safeguards are listed. The unilateral embargo of nuclear exports by U.S. is proposed. Political measures to discourage nations from acquiring nuclear weapons are also listed. Only a combination of political, psychological, and technical measures can produce an effective nonproliferation regime

Nuclear fuel pellet loading apparatus

International Nuclear Information System (INIS)

Gerkey, K.S.

1979-01-01

An automatic apparatus for loading a predetermined amount of nuclear fuel pellets into a nuclear fuel element to be used in a nuclear reactor is described. The apparatus consists of a vibratory bed capable of supporting corrugated trays containing rows of nuclear fuel pellets and arranged in alignment with the open ends of several nuclear fuel elements. A sweep mechanism is arranged above the trays and serves to sweep the rows of fuel pellets onto the vibratory bed and into the fuel element. A length detecting system, in conjunction with a pellet stopping mechanism, is also provided to assure that a predetermined amount of nuclear fuel pellets are loaded into each fuel element

Nuclear fuel

International Nuclear Information System (INIS)

Azevedo, J.B.L. de.

1980-01-01

All stages of nuclear fuel cycle are analysed with respect to the present situation and future perspectives of supply and demand of services; the prices and the unitary cost estimation of these stages for the international fuel market are also mentioned. From the world resources and projections of uranium consumption, medium-and long term analyses are made of fuel availability for several strategies of use of different reactor types. Finally, the cost of nuclear fuel in the generation of electric energy is calculated to be used in the energetic planning of the electric sector. (M.A.) [pt

Nuclear power and the nuclear fuel cycle

International Nuclear Information System (INIS)

Hardy, C.J.; Silver, J.M.

1985-09-01

The report provides data and assessments of the status and prospects of nuclear power and the nuclear fuel cycle. The report discusses the economic competitiveness of nuclear electricity generation, the extent of world uranium resources, production and requirements, uranium conversion and enrichment, fuel fabrication, spent fuel treatment and radioactive waste management. A review is given of the status of nuclear fusion research

76 FR 72984 - Revised Application for a License To Export High-Enriched Uranium

Science.gov (United States)

2011-11-28

... NUCLEAR REGULATORY COMMISSION Revised Application for a License To Export High-Enriched Uranium The application for a license to export high-enriched Uranium has been revised as noted below. Notice... fabricate fuel France. Security Complex; October 18, Uranium (93.35%). uranium (174.0 elements in France...

Quantitative Analysis of the Civilian Bilateral Cooperation in Front-End of the Nuclear Fuel Cycle

Energy Technology Data Exchange (ETDEWEB)

Nguyen, Viet Phuong; Yim, Man-Sung [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

2015-05-15

A substantial part of such cooperation is related to the front-end of the nuclear fuel cycle, which encompasses the processes that help manufacturing nuclear fuel, including mining and milling of natural uranium, refining and chemical conversion, enrichment (in case of fuels for Pressurized Water Reactor PWR), and fuel fabrication. Traditionally, the supply of natural uranium was dominated by Canada and Australia, whereas enrichment services have been mostly provided by companies from Western states or Russia, which are also the main customers of such services. However, Kazakhstan and African countries like Niger, Namibia, and Malawi have emerged as important suppliers in the international uranium market and recent forecasts show that China will soon become a major player in the front-end market as both consumer and service provider. In this paper, the correlation between bilateral civil nuclear cooperation in front-end of the nuclear fuel cycle and the political and economic relationship among countries was examined through a dataset of bilateral nuclear cooperation in the post-Cold War era, from 1990 to 2011. Such finding has implication on not only the nonproliferation research but also the necessary reinforcement of export control regimes like such as the Nuclear Suppliers Group. Further improvement of this dataset and the regression method are also needed in order to increase the robustness of the findings as well as to cover the whole scope of the nuclear fuel cycle, including both front-end and back-end activities.

Quantitative Analysis of the Civilian Bilateral Cooperation in Front-End of the Nuclear Fuel Cycle

International Nuclear Information System (INIS)

Nguyen, Viet Phuong; Yim, Man-Sung

2015-01-01

A substantial part of such cooperation is related to the front-end of the nuclear fuel cycle, which encompasses the processes that help manufacturing nuclear fuel, including mining and milling of natural uranium, refining and chemical conversion, enrichment (in case of fuels for Pressurized Water Reactor PWR), and fuel fabrication. Traditionally, the supply of natural uranium was dominated by Canada and Australia, whereas enrichment services have been mostly provided by companies from Western states or Russia, which are also the main customers of such services. However, Kazakhstan and African countries like Niger, Namibia, and Malawi have emerged as important suppliers in the international uranium market and recent forecasts show that China will soon become a major player in the front-end market as both consumer and service provider. In this paper, the correlation between bilateral civil nuclear cooperation in front-end of the nuclear fuel cycle and the political and economic relationship among countries was examined through a dataset of bilateral nuclear cooperation in the post-Cold War era, from 1990 to 2011. Such finding has implication on not only the nonproliferation research but also the necessary reinforcement of export control regimes like such as the Nuclear Suppliers Group. Further improvement of this dataset and the regression method are also needed in order to increase the robustness of the findings as well as to cover the whole scope of the nuclear fuel cycle, including both front-end and back-end activities

Can fuel services supply be secured? Building trust in a multi-lateral approach to nuclear fuel cycles

Energy Technology Data Exchange (ETDEWEB)

Antoine, B. [Engineering Systems Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room E40-261, Cambridge, MA 02139 (United States); Rodriguez-Vieitez, E. [Belfer Center for Science and International Affairs, Kennedy School of Government, Harvard University, One Brattle Sq., Room 503, Cambridge, MA 02138 (United States)

2009-06-15

Global climate change and concerns about energy supply security fuelling the nuclear desires of an increasing number of states, there is growing interest within the nonproliferation community to promote the establishment of an international system for the provision of nuclear fuel cycle services that would be 'equitable and accessible to all users of nuclear energy' (Rauf, 2008) while reducing proliferation risks. Although the idea was already voiced on the cradle of civilian use of nuclear energy (Baruch, 1946), the IAEA director's 2003 call for a group of international experts to examine the issue (ElBaradei, 2003) triggered renewed interest that resulted in up to twelve different proposals for multilateral nuclear fuel cycle arrangements (Rauf, 2008; Simpson, 2008). Nonproliferation experts have examined the conditions under which equitable and accessible access to enrichment, reprocessing and spent fuel disposal services can be granted to all users (Rauf, 2008; Braun 2006; Pellaud and al 2005). They suggested putting together multilateral nuclear approaches (MNA) that could consist in the establishment of mechanisms to assure fuel cycle services, or the shared ownership by recipient and host countries of fuel services facilities through either the creation of new multilateral centers or the conversion of existing national facilities into multinational enterprises. While countries that possess nuclear fuel facilities would benefit from the increased global security and strengthened non-proliferation situation that would result from the establishment of these MNAs, they would also be baited into participating by possible attraction of foreign investments as well as the opportunity to export high value services (Rushkin, 2006). Yet, what incentives would there be for a recipient non-nuclear state to participate in an arrangement that would intrinsically strip it of its sovereign right to ensure its fuel supply security? In addition to the economic

Identification of a nuclear export signal in the KSHV latent protein LANA2 mediating its export from the nucleus

International Nuclear Information System (INIS)

Munoz-Fontela, C.; Collado, M.; Rodriguez, E.; Garcia, M.A.; Alvarez-Barrientos, A.; Arroyo, J.; Nombela, C.; Rivas, C.

2005-01-01

LANA2 is a latent protein detected in Kaposi's sarcoma-associated herpesvirus (KSHV)-infected B cells that inhibits p53-dependent transcriptional transactivation and apoptosis and PKR-dependent apoptosis, suggesting an important role in the transforming activity of the virus. It has been reported that LANA2 localizes into the nucleus of both KSHV-infected B cells and transiently transfected HeLa cells. In this study, we show that LANA2 is a nucleocytoplasmic shuttling protein that requires a Rev-type nuclear export signal located in the C-terminus to direct the protein to the cytoplasm, through an association with the export receptor CRM1. In addition, a functional protein kinase B (PKB)/Akt phosphorylation motif partially overlapping with the nuclear export signal was identified. Nuclear exclusion of LANA2 was negatively regulated by the phosphorylation of threonine 564 by Akt. The ability of LANA2 to shuttle between nucleus and cytoplasm has implications for the function of this viral protein

Canada's nuclear fuel industry: An overview. Background paper

International Nuclear Information System (INIS)

Nixon, A.

1993-11-01

Canada was among the first countries to mine and process uranium-bearing ores. Such ores contain trace amounts of radium, which was in great demand for medical treatment and for use by research laboratories in the early part of the century. For the last half century, the same basic processes have been used to extract uranium from its ores and convert it to a form suitable for use in nuclear reactors. The process described here is that currently in use in Canada. Mining can take a variety of forms, from open-pit to deep, hard-rock. Mining is typically the most costly step in the process, particularly for lower-grade ores. The ore is crushed and ground in the mill to the consistency of fine sand from which the uranium is extracted chemically to produce the impure concentrate known as yellowcake. In the next step, the impure uranium concentrate is chemically refined into highly purified, nuclear-grade, uranium trioxide (UO 3 ). Uranium trioxide is then converted, in two separate chemical processes, into uranium dioxide (UO 2 ) which is destined for domestic consumption and uranium hexafluoride (UF 6 ) which is exported. In Canada, fabrication is the final step of the fuel production process. Uranium dioxide powder is compressed and sintered into very dense ceramic pellets which are then sealed in zirconium tubes and assembled into fuel bundles for Candu reactors. This background paper will review the Canadian nuclear fuels industry. 1 fig

Mutation of a Conserved Nuclear Export Sequence in Chikungunya Virus Capsid Protein Disrupts Host Cell Nuclear Import.

Science.gov (United States)

Jacobs, Susan C; Taylor, Adam; Herrero, Lara J; Mahalingam, Suresh; Fazakerley, John K

2017-10-20

Transmitted by mosquitoes; chikungunya virus (CHIKV) is responsible for frequent outbreaks of arthritic disease in humans. CHIKV is an arthritogenic alphavirus of the Togaviridae family. Capsid protein, a structural protein encoded by the CHIKV RNA genome, is able to translocate to the host cell nucleus. In encephalitic alphaviruses nuclear translocation induces host cell shut off; however, the role of capsid protein nuclear localisation in arthritogenic alphaviruses remains unclear. Using replicon systems, we investigated a nuclear export sequence (NES) in the N-terminal region of capsid protein; analogous to that found in encephalitic alphavirus capsid but uncharacterised in CHIKV. The chromosomal maintenance 1 (CRM1) export adaptor protein mediated CHIKV capsid protein export from the nucleus and a region within the N-terminal part of CHIKV capsid protein was required for active nuclear targeting. In contrast to encephalitic alphaviruses, CHIKV capsid protein did not inhibit host nuclear import; however, mutating the NES of capsid protein (∆NES) blocked host protein access to the nucleus. Interactions between capsid protein and the nucleus warrant further investigation.

Nuclear fuel accounting

International Nuclear Information System (INIS)

Aisch, D.E.

1977-01-01

After a nuclear power plant has started commercial operation the actual nuclear fuel costs have to be demonstrated in the rate making procedure. For this purpose an accounting system has to be developed which comprises the following features: 1) All costs associated with nuclear fuel shall be correctly recorded; 2) it shall be sufficiently flexible to cover also deviations from proposed core loading patterns; 3) it shall be applicable to different fuel cycle schemes. (orig./RW) [de

Nuclear Fuel Cycle Information System. A directory of nuclear fuel cycle facilities. 2009 ed

International Nuclear Information System (INIS)

2009-04-01

The Nuclear Fuel Cycle Information System (NFCIS) is an international directory of civilian nuclear fuel cycle facilities, published online as part of the Integrated Nuclear Fuel Cycle Information System (iNFCIS: http://www-nfcis.iaea.org/). This is the fourth hardcopy publication in almost 30 years and it represents a snapshot of the NFCIS database as of the end of 2008. Together with the attached CD-ROM, it provides information on 650 civilian nuclear fuel cycle facilities in 53 countries, thus helping to improve the transparency of global nuclear fuel cycle activities

KLF4 Nuclear Export Requires ERK Activation and Initiates Exit from Naive Pluripotency.

Science.gov (United States)

Dhaliwal, Navroop K; Miri, Kamelia; Davidson, Scott; Tamim El Jarkass, Hala; Mitchell, Jennifer A

2018-04-10

Cooperative action of a transcription factor complex containing OCT4, SOX2, NANOG, and KLF4 maintains the naive pluripotent state; however, less is known about the mechanisms that disrupt this complex, initiating exit from pluripotency. We show that, as embryonic stem cells (ESCs) exit pluripotency, KLF4 protein is exported from the nucleus causing rapid decline in Nanog and Klf4 transcription; as a result, KLF4 is the first pluripotency transcription factor removed from transcription-associated complexes during differentiation. KLF4 nuclear export requires ERK activation, and phosphorylation of KLF4 by ERK initiates interaction of KLF4 with nuclear export factor XPO1, leading to KLF4 export. Mutation of the ERK phosphorylation site in KLF4 (S132) blocks KLF4 nuclear export, the decline in Nanog, Klf4, and Sox2 mRNA, and differentiation. These findings demonstrate that relocalization of KLF4 to the cytoplasm is a critical first step in exit from the naive pluripotent state and initiation of ESC differentiation. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

The nuclear fuel cycle

International Nuclear Information System (INIS)

1998-05-01

After a short introduction about nuclear power in the world, fission physics and the French nuclear power plants, this brochure describes in a digest way the different steps of the nuclear fuel cycle: uranium prospecting, mining activity, processing of uranium ores and production of uranium concentrates (yellow cake), uranium chemistry (conversion of the yellow cake into uranium hexafluoride), fabrication of nuclear fuels, use of fuels, reprocessing of spent fuels (uranium, plutonium and fission products), recycling of energetic materials, and storage of radioactive wastes. (J.S.)

Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein.

Science.gov (United States)

Yanai, Mako; Sakai, Madoka; Makino, Akiko; Tomonaga, Keizo

2017-07-11

Borna disease virus (BoDV), which has a negative-sense, single-stranded RNA genome, causes persistent infection in the cell nucleus. The nuclear export signal (NES) of the viral nucleoprotein (N) consisting of leucine at positions 128 and 131 and isoleucine at positions 133 and 136 overlaps with one of two predicted binding sites for the viral phosphoprotein (P). A previous study demonstrated that higher expression of BoDV-P inhibits nuclear export of N; however, the function of N NES in the interaction with P remains unclear. We examined the subcellular localization, viral polymerase activity, and P-binding ability of BoDV-N NES mutants. We also characterized a recombinant BoDV (rBoDV) harboring an NES mutation of N. BoDV-N with four alanine-substitutions in the leucine and isoleucine residues of the NES impaired its cytoplasmic localization and abolished polymerase activity and P-binding ability. Although an alanine-substitution at position 131 markedly enhanced viral polymerase activity as determined by a minigenome assay, rBoDV harboring this mutation showed expression of viral RNAs and proteins relative to that of wild-type rBoDV. Our results demonstrate that BoDV-N NES has a dual function in BoDV replication, i.e., nuclear export of N and an interaction with P, affecting viral polymerase activity in the nucleus.

Nuclear fuel element

International Nuclear Information System (INIS)

Penrose, R.T.; Thompson, J.R.

1976-01-01

A method of protecting the cladding of a nuclear fuel element from internal attack and a nuclear fuel element for use in the core of a nuclear reactor are disclosed. The nuclear fuel element has disposed therein an additive of a barium-containing material and the barium-containing material collects reactive gases through chemical reaction or adsorption at temperatures ranging from room temperature up to fuel element plenum temperatures. The additive is located in the plenum of the fuel element and preferably in the form of particles in a hollow container having a multiplicity of gas permeable openings in one portion of the container with the openings being of a size smaller than the size of the particles. The openings permit gases and liquids entering the plenum to contact the particles. The additive is comprised of elemental barium or a barium alloy containing one or more metals in addition to barium such as aluminum, zirconium, nickel, titanium and combinations thereof. 6 claims, 3 drawing figures

Characterization of the ptr5+ gene involved in nuclear mRNA export in fission yeast

International Nuclear Information System (INIS)

Watanabe, Nobuyoshi; Ikeda, Terumasa; Mizuki, Fumitaka; Tani, Tokio

2012-01-01

Highlights: ► We cloned the ptr5 + gene involved in nuclear mRNA export in fission yeast. ► The ptr5 + gene was found to encode nucleoporin 85 (Nup85). ► Seh1p and Mlo3p are multi-copy suppressors for the ptr5 mutation. ► Ptr5p/Nup85p functions in nuclear mRNA export through the mRNA export factor Rae1p. ► Ptr5p/Nup85p interacts genetically with pre-mRNA splicing factors. -- Abstract: To analyze the mechanisms of mRNA export from the nucleus to the cytoplasm, we have isolated eleven mutants, ptr [poly(A) + RNA transport] 1 to 11, which accumulate poly(A) + RNA in the nucleus at a nonpermissive temperature in Schizosaccharomyces pombe. Of those, the ptr5–1 mutant shows dots- or a ring-like accumulation of poly(A) + RNA at the nuclear periphery after shifting to the nonpermissive temperature. We cloned the ptr5 + gene and found that it encodes a component of the nuclear pore complex (NPC), nucleoporin 85 (Nup85). The ptr5–1 mutant shows no defects in protein transport, suggesting the specific involvement of Ptr5p/Nup85p in nuclear mRNA export in S. pombe. We identified Seh1p, a nucleoporin interacting with Nup85p, an mRNA-binding protein Mlo3p, and Sac3p, a component of the TREX-2 complex involved in coupling of nuclear mRNA export with transcription, as multi-copy suppressors for the ptr5–1 mutation. In addition, we found that the ptr5–1 mutation is synthetically lethal with a mutation of the mRNA export factor Rae1p, and that the double mutant exaggerates defective nuclear mRNA export, suggesting that Ptr5p/Nup85p is involved in nuclear mRNA export through Rae1p. Interestingly, the ptr5–1 mutation also showed synthetic effects with several prp pre-mRNA splicing mutations, suggesting a functional linkage between the NPCs and the splicing apparatus in the yeast nucleus.

RanBP3 influences interactions between CRM1 and its nuclear protein export substrates

OpenAIRE

Englmeier, Ludwig; Fornerod, Maarten; Bischoff, F. Ralf; Petosa, Carlo; Mattaj, Iain W.; Kutay, Ulrike

2001-01-01

We investigated the role of RanBP3, a nuclear member of the Ran-binding protein 1 family, in CRM1-mediated protein export in higher eukaryotes. RanBP3 interacts directly with CRM1 and also forms a trimeric complex with CRM1 and RanGTP. However, RanBP3 does not bind to CRM1 like an export substrate. Instead, it can stabilize CRM1–export substrate interaction. Nuclear RanBP3 stimulates CRM1-dependent protein export in permeabilized cells. These data indicate that RanBP3 functions by a novel mec...

A subset of FG-nucleoporins is necessary for efficient Msn5-mediated nuclear protein export

Science.gov (United States)

Finn, Erin M.; DeRoo, Elise P.; Clement, George W.; Rao, Sheila; Kruse, Sarah E.; Kokanovich, Kate M.; Belanger, Kenneth D.

2013-01-01

The transport of proteins between the cytoplasm and nucleus requires interactions between soluble transport receptors (karyopherins) and phenylalanine-glycine (FG) repeat domains on nuclear pore complex proteins (nucleoporins). However, the role of specific FG repeat-containing nucleoporins in nuclear protein export has not been carefully investigated. We have developed a novel kinetic assay to investigate the relative export kinetics mediated by the karyopherin Msn5/Kap142 in yeast containing specific FG-Nup mutations. Using the Msn5 substrate Crz1 as a marker for Msn5-mediated protein export, we observe that deletions of NUP100 or NUP2 result in decreased rates of Crz1 export, while nup60Δ and nup42Δ mutants do not vary significantly from wild type. The decreased Msn5 export rate in nup100Δ was confirmed using Mig1-GFP as a transport substrate. A nup100ΔGLFG mutant shows defects in nuclear export kinetics similar to a nup100Δ deletion. Removal of FG-repeats from Nsp1 also decreases export kinetics, while a loss of Nup1 FXFGs does not. To confirm that our export data reflected functional differences in protein localization, we performed Crz1 transcription activation assays using a CDRE::LacZ reporter gene that is upregulated upon increased transcription activation by Crz1 in vivo. We observe that expression from this reporter increases in nup100ΔGLFG and nsp1ΔFGΔFXFG strains that exhibit decreased Crz1 export kinetics but resembles wild-type levels in nup1ΔFXFG strains that do not exhibit export defects. These data provide evidence that the export of Msn5 is likely mediated by a specific subset of FG-Nups and that the GLFG repeat domain of Nup100 is important for Msn5-mediated nuclear protein export. PMID:23295456

Device for separating, purifying and recovering nuclear fuel material, impurities and materials from impurity-containing nuclear fuel materials or nuclear fuel containing material

International Nuclear Information System (INIS)

Sato, Ryuichi; Kamei, Yoshinobu; Watanabe, Tsuneo; Tanaka, Shigeru.

1988-01-01

Purpose: To separate, purify and recover nuclear fuel materials, impurities and materials with no formation of liquid wastes. Constitution: Oxidizing atmosphere gases are introduced from both ends of a heating furnace. Vessels containing impurity-containing nuclear fuel substances or nuclear fuel substance-containing material are continuously disposed movably from one end to the other of the heating furnace. Then, impurity oxides or material oxides selectively evaporated from the impurity-containing nuclear fuel substances or nuclear fuel substance-containing materials are entrained in the oxidizing atmosphere gas and the gases are led out externally from a discharge port opened at the intermediate portion of the heating furnace, filters are disposed to the exit to solidify and capture the nuclear fuel substances and traps are disposed behind the filters to solidify and capture the oxides by spontaneous air cooling or water cooling. (Sekiya, K.)

Exports of petroleum products, 1987

International Nuclear Information System (INIS)

1988-04-01

A summary is presented of exports of motor gasoline, middle distillate, aviation turbine fuel, heavy fuel oil, and partially processed oil from Canada for the 1987 calendar year. A discussion of petroleum product imports is included in order to put exports in the context of the overall trade. Exports of the above petroleum products averaged 22,200 m 3 /d in 1987, up 15% from 1986 levels. Exports of middle distillates and aviation fuel had the largest gains in 1987. Export prices for light petroleum products stayed relatively close to USA spot prices. The heavy fuel oil price was below the New York spot price in the beginning of 1987 but remained close for the rest of the year. Canada's petroleum products exports were made to 5 countries while imports came from at least 13 countries. The USA remained Canada's largest trading partner in petroleum products. Exports to Japan and the Far East rose ca 60% over 1986. Product outturns for export were 9% of total Canadian refinery throughput. Exports of aviation turbine fuel from Ontario began in April 1987. The top single exporter in Canada was Irving Oil Ltd. with 2,485,000 m 3 . Irving was also the top exporter in 1986. 11 figs., 4 tabs

One recommendation of nuclear power export. GDP model application to the countries which expressed nuclear power introduction and consideration

International Nuclear Information System (INIS)

Iida, Tekehiko

2010-01-01

South Korea has been excited in nuclear business after the success in the contract to build nuclear power plants in UAE. Since more than 60 countries expressed nuclear power introduction and new countries were on the rise with exporting reactor technology accumulated, new era over nuclear renaissance seems to begin. This article at first classified countries, which expressed nuclear power introduction, with an economic level of GDP per capita. Then each classified country's requirements of nuclear power introduction were taken into consideration such as economic development, consumption pattern and technology attitude. As a result recommendation of nuclear power export was proposed. Different approach to each country targeted was suggested as shown in 'nuclear power GDP model'. (T. Tanaka)

Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells

Science.gov (United States)

Lombardi, Maria; Castoria, Gabriella; Migliaccio, Antimo; Barone, Maria Vittoria; Di Stasio, Rosina; Ciociola, Alessandra; Bottero, Daniela; Yamaguchi, Hiroshi; Appella, Ettore; Auricchio, Ferdinando

2008-01-01

In breast cancer cells, cytoplasmic localization of the estradiol receptor α (ERα) regulates estradiol-dependent S phase entry. We identified a nuclear export sequence (NES) in ERα and show that its export is dependent on both estradiol-mediated phosphatidylinositol-3-kinase (PI3K)/AKT activation and chromosome region maintenance 1 (CRM1). A Tat peptide containing the ERα NES disrupts ERα–CRM1 interaction and prevents nuclear export of ERα- and estradiol-induced DNA synthesis. NES-ERα mutants do not exit the nucleus and inhibit estradiol-induced S phase entry; ERα-dependent transcription is normal. ERα is associated with Forkhead proteins in the nucleus, and estradiol stimulates nuclear exit of both proteins. ERα knockdown or ERα NES mutations prevent ERα and Forkhead nuclear export. A mutant of forkhead in rhabdomyosarcoma (FKHR), which cannot be phosphorylated by estradiol-activated AKT, does not associate with ERα and is trapped in the nucleus, blocking S phase entry. In conclusion, estradiol-induced AKT-dependent phosphorylation of FKHR drives its association with ERα, thereby triggering complex export from the nucleus necessary for initiation of DNA synthesis and S phase entry. PMID:18644889

NESmapper: accurate prediction of leucine-rich nuclear export signals using activity-based profiles.

Directory of Open Access Journals (Sweden)

Shunichi Kosugi

2014-09-01

Full Text Available The nuclear export of proteins is regulated largely through the exportin/CRM1 pathway, which involves the specific recognition of leucine-rich nuclear export signals (NESs in the cargo proteins, and modulates nuclear-cytoplasmic protein shuttling by antagonizing the nuclear import activity mediated by importins and the nuclear import signal (NLS. Although the prediction of NESs can help to define proteins that undergo regulated nuclear export, current methods of predicting NESs, including computational tools and consensus-sequence-based searches, have limited accuracy, especially in terms of their specificity. We found that each residue within an NES largely contributes independently and additively to the entire nuclear export activity. We created activity-based profiles of all classes of NESs with a comprehensive mutational analysis in mammalian cells. The profiles highlight a number of specific activity-affecting residues not only at the conserved hydrophobic positions but also in the linker and flanking regions. We then developed a computational tool, NESmapper, to predict NESs by using profiles that had been further optimized by training and combining the amino acid properties of the NES-flanking regions. This tool successfully reduced the considerable number of false positives, and the overall prediction accuracy was higher than that of other methods, including NESsential and Wregex. This profile-based prediction strategy is a reliable way to identify functional protein motifs. NESmapper is available at http://sourceforge.net/projects/nesmapper.

77 FR 51581 - Request for a License To Export Nuclear Grade Graphite

Science.gov (United States)

2012-08-24

... NUCLEAR REGULATORY COMMISSION Request for a License To Export Nuclear Grade Graphite Pursuant to... 27, 2012, graphite for of nuclear grade graphite to the XMAT424, 11006032. nuclear end use. graphite. Shanghai Institute of Applied Physics in China to test various types of nuclear grade graphite material in...

A study on improvement of export control system for the nuclear facility

International Nuclear Information System (INIS)

Kim, Ok Joo; Shin, Dong Hoon; Yang, Seung Hyo

2012-01-01

The Republic of Korea joined Nuclear Suppliers Group(NSG) in 1995 and became a major nuclear supplier both in name and reality by contracting the Project of UAE Braka Nuclear Power Plant(BNPP) in 2009 and the Project of Jordan Research and Training Reactor(JRTR) in 2010. And ROK is currently negotiating with several countries such as Finland and Vietnam for more projects, so it is expected to obtain more orders of commercial and research reactor. At this point of time, we found that it is difficult to apply individual export licensing system as it is for the big nuclear project such as BNPP and JRTR Project. Because the nuclear project in foreign country contains transfer of thousands of items and technical documents, including a considerable number of strategic items, issuing individual licenses for all items and documents can cause the inefficiency of the project. So, an appropriate export control system which can support such a project is necessary. In this study, we focused on how to improve the export control system to guarantee not only time efficiency but careful management of strategic goods

World nuclear fuel cycle requirements 1991

Energy Technology Data Exchange (ETDEWEB)

1991-10-10

The nuclear fuel cycle consists of mining and milling uranium ore, processing the uranium into a form suitable for generating electricity, burning'' the fuel in nuclear reactors, and managing the resulting spent nuclear fuel. This report presents projections of domestic and foreign requirements for natural uranium and enrichment services as well as projections of discharges of spent nuclear fuel. These fuel cycle requirements are based on the forecasts of future commercial nuclear power capacity and generation published in a recent Energy Information Administration (EIA) report. Also included in this report are projections of the amount of spent fuel discharged at the end of each fuel cycle for each nuclear generating unit in the United States. The International Nuclear Model is used for calculating the projected nuclear fuel cycle requirements. 14 figs., 38 tabs.

World nuclear fuel cycle requirements 1991

International Nuclear Information System (INIS)

1991-01-01

The nuclear fuel cycle consists of mining and milling uranium ore, processing the uranium into a form suitable for generating electricity, ''burning'' the fuel in nuclear reactors, and managing the resulting spent nuclear fuel. This report presents projections of domestic and foreign requirements for natural uranium and enrichment services as well as projections of discharges of spent nuclear fuel. These fuel cycle requirements are based on the forecasts of future commercial nuclear power capacity and generation published in a recent Energy Information Administration (EIA) report. Also included in this report are projections of the amount of spent fuel discharged at the end of each fuel cycle for each nuclear generating unit in the United States. The International Nuclear Model is used for calculating the projected nuclear fuel cycle requirements. 14 figs., 38 tabs

Nuclear fuels

International Nuclear Information System (INIS)

Beauvy, M.; Berthoud, G.; Defranceschi, M.; Ducros, G.; Guerin, Y.; Limoge, Y.; Madic, Ch.; Santarini, G.; Seiler, J.M.; Sollogoub, P.; Vernaz, E.; Guillet, J.L.; Ballagny, A.; Bechade, J.L.; Bonin, B.; Brachet, J.Ch.; Delpech, M.; Dubois, S.; Ferry, C.; Freyss, M.; Gilbon, D.; Grouiller, J.P.; Iracane, D.; Lansiart, S.; Lemoine, P.; Lenain, R.; Marsault, Ph.; Michel, B.; Noirot, J.; Parrat, D.; Pelletier, M.; Perrais, Ch.; Phelip, M.; Pillon, S.; Poinssot, Ch.; Vallory, J.; Valot, C.; Pradel, Ph.; Bonin, B.; Bouquin, B.; Dozol, M.; Lecomte, M.; Vallee, A.; Bazile, F.; Parisot, J.F.; Finot, P.; Roberts, J.F.

2009-01-01

Fuel is one of the essential components in a reactor. It is within that fuel that nuclear reactions take place, i.e. fission of heavy atoms, uranium and plutonium. Fuel is at the core of the reactor, but equally at the core of the nuclear system as a whole. Fuel design and properties influence reactor behavior, performance, and safety. Even though it only accounts for a small part of the cost per kilowatt-hour of power provided by current nuclear power plants, good utilization of fuel is a major economic issue. Major advances have yet to be achieved, to ensure longer in-reactor dwell-time, thus enabling fuel to yield more energy; and improve ruggedness. Aside from economics, and safety, such strategic issues as use of plutonium, conservation of resources, and nuclear waste management have to be addressed, and true technological challenges arise. This Monograph surveys current knowledge regarding in-reactor behavior, operating limits, and avenues for R and D. It also provides illustrations of ongoing research work, setting out a few noteworthy results recently achieved. Content: 1 - Introduction; 2 - Water reactor fuel: What are the features of water reactor fuel? 9 (What is the purpose of a nuclear fuel?, Ceramic fuel, Fuel rods, PWR fuel assemblies, BWR fuel assemblies); Fabrication of water reactor fuels (Fabrication of UO 2 pellets, Fabrication of MOX (mixed uranium-plutonium oxide) pellets, Fabrication of claddings); In-reactor behavior of UO 2 and MOX fuels (Irradiation conditions during nominal operation, Heat generation, and removal, The processes involved at the start of irradiation, Fission gas behavior, Microstructural changes); Water reactor fuel behavior in loss of tightness conditions (Cladding, the first containment barrier, Causes of failure, Consequences of a failure); Microscopic morphology of fuel ceramic and its evolution under irradiation; Migration and localization of fission products in UOX and MOX matrices (The ceramic under irradiation

Nuclear fuels

Energy Technology Data Exchange (ETDEWEB)

Beauvy, M.; Berthoud, G.; Defranceschi, M.; Ducros, G.; Guerin, Y.; Limoge, Y.; Madic, Ch.; Santarini, G.; Seiler, J.M.; Sollogoub, P.; Vernaz, E.; Guillet, J.L.; Ballagny, A.; Bechade, J.L.; Bonin, B.; Brachet, J.Ch.; Delpech, M.; Dubois, S.; Ferry, C.; Freyss, M.; Gilbon, D.; Grouiller, J.P.; Iracane, D.; Lansiart, S.; Lemoine, P.; Lenain, R.; Marsault, Ph.; Michel, B.; Noirot, J.; Parrat, D.; Pelletier, M.; Perrais, Ch.; Phelip, M.; Pillon, S.; Poinssot, Ch.; Vallory, J.; Valot, C.; Pradel, Ph.; Bonin, B.; Bouquin, B.; Dozol, M.; Lecomte, M.; Vallee, A.; Bazile, F.; Parisot, J.F.; Finot, P.; Roberts, J.F

2009-07-01

Fuel is one of the essential components in a reactor. It is within that fuel that nuclear reactions take place, i.e. fission of heavy atoms, uranium and plutonium. Fuel is at the core of the reactor, but equally at the core of the nuclear system as a whole. Fuel design and properties influence reactor behavior, performance, and safety. Even though it only accounts for a small part of the cost per kilowatt-hour of power provided by current nuclear power plants, good utilization of fuel is a major economic issue. Major advances have yet to be achieved, to ensure longer in-reactor dwell-time, thus enabling fuel to yield more energy; and improve ruggedness. Aside from economics, and safety, such strategic issues as use of plutonium, conservation of resources, and nuclear waste management have to be addressed, and true technological challenges arise. This Monograph surveys current knowledge regarding in-reactor behavior, operating limits, and avenues for R and D. It also provides illustrations of ongoing research work, setting out a few noteworthy results recently achieved. Content: 1 - Introduction; 2 - Water reactor fuel: What are the features of water reactor fuel? 9 (What is the purpose of a nuclear fuel?, Ceramic fuel, Fuel rods, PWR fuel assemblies, BWR fuel assemblies); Fabrication of water reactor fuels (Fabrication of UO{sub 2} pellets, Fabrication of MOX (mixed uranium-plutonium oxide) pellets, Fabrication of claddings); In-reactor behavior of UO{sub 2} and MOX fuels (Irradiation conditions during nominal operation, Heat generation, and removal, The processes involved at the start of irradiation, Fission gas behavior, Microstructural changes); Water reactor fuel behavior in loss of tightness conditions (Cladding, the first containment barrier, Causes of failure, Consequences of a failure); Microscopic morphology of fuel ceramic and its evolution under irradiation; Migration and localization of fission products in UOX and MOX matrices (The ceramic under

Comparative analysis of seven viral nuclear export signals (NESs reveals the crucial role of nuclear export mediated by the third NES consensus sequence of nucleoprotein (NP in influenza A virus replication.

Directory of Open Access Journals (Sweden)

Nopporn Chutiwitoonchai

Full Text Available The assembly of influenza virus progeny virions requires machinery that exports viral genomic ribonucleoproteins from the cell nucleus. Currently, seven nuclear export signal (NES consensus sequences have been identified in different viral proteins, including NS1, NS2, M1, and NP. The present study examined the roles of viral NES consensus sequences and their significance in terms of viral replication and nuclear export. Mutation of the NP-NES3 consensus sequence resulted in a failure to rescue viruses using a reverse genetics approach, whereas mutation of the NS2-NES1 and NS2-NES2 sequences led to a strong reduction in viral replication kinetics compared with the wild-type sequence. While the viral replication kinetics for other NES mutant viruses were also lower than those of the wild-type, the difference was not so marked. Immunofluorescence analysis after transient expression of NP-NES3, NS2-NES1, or NS2-NES2 proteins in host cells showed that they accumulated in the cell nucleus. These results suggest that the NP-NES3 consensus sequence is mostly required for viral replication. Therefore, each of the hydrophobic (Φ residues within this NES consensus sequence (Φ1, Φ2, Φ3, or Φ4 was mutated, and its viral replication and nuclear export function were analyzed. No viruses harboring NP-NES3 Φ2 or Φ3 mutants could be rescued. Consistent with this, the NP-NES3 Φ2 and Φ3 mutants showed reduced binding affinity with CRM1 in a pull-down assay, and both accumulated in the cell nucleus. Indeed, a nuclear export assay revealed that these mutant proteins showed lower nuclear export activity than the wild-type protein. Moreover, the Φ2 and Φ3 residues (along with other Φ residues within the NP-NES3 consensus were highly conserved among different influenza A viruses, including human, avian, and swine. Taken together, these results suggest that the Φ2 and Φ3 residues within the NP-NES3 protein are important for its nuclear export function

Spent nuclear fuel storage

International Nuclear Information System (INIS)

Romanato, Luiz Sergio

2005-01-01

When a country becomes self-sufficient in part of the nuclear cycle, as production of fuel that will be used in nuclear power plants for energy generation, it is necessary to pay attention for the best method of storing the spent fuel. Temporary storage of spent nuclear fuel is a necessary practice and is applied nowadays all over the world, so much in countries that have not been defined their plan for a definitive repository, as well for those that already put in practice such storage form. There are two main aspects that involve the spent fuels: one regarding the spent nuclear fuel storage intended to reprocessing and the other in which the spent fuel will be sent for final deposition when the definitive place is defined, correctly located, appropriately characterized as to several technical aspects, and licentiate. This last aspect can involve decades of studies because of the technical and normative definitions at a given country. In Brazil, the interest is linked with the storage of spent fuels that will not be reprocessed. This work analyses possible types of storage, the international panorama and a proposal for future construction of a spent nuclear fuel temporary storage place in the country. (author)

Harmonization between a Framework of Multilateral Approaches to Nuclear Fuel Cycle Facilities and Bilateral Nuclear Cooperation Agreements

Directory of Open Access Journals (Sweden)

Makiko Tazaki

2013-09-01

Full Text Available One of primary challenges for ensuring effective and efficient functions of the multilateral nuclear approaches (MNA to nuclear fuel cycle facilities is harmonization between a MNA framework and existing nuclear cooperation agreements (NCA. A method to achieve such harmonization is to construct a MNA framework with robust non-proliferation characteristics, in order to obtain supplier states’, especially the US’s prior consents for non-supplier states’ certain activities including spent fuel reprocessing, plutonium storages and retransfers of plutonium originated in NCAs. Such robust characteristics can be accomplished by MNA member states’ compliances with International Atomic Energy Agency (IAEA Safeguards, regional safeguards agreements, international conventions, guidelines and recommendations on nuclear non-proliferation, nuclear security, safety, and export control. Those provisions are to be incorporated into an MNA founding agreement, as requirements to be MNA members in relation to NCAs. Furthermore, if an MNA facility is, (1 owned and operated jointly by all MNA member states, (2 able to conclude bilateral NCAs with non-MNA/supplier states as a single legal entity representing its all member states like an international organization, and (3 able to obtain necessary prior consents, stable, smooth, and timely supplies of nuclear fuel and services can be assured among MNA member states. In this paper, the authors will set out a general MNA framework and then apply it to a specific example of Europe Atomic Energy Community (EURATOM and then consider its applicability to the Asian region, where an establishment of an MNA framework is expected to be explored.

Spent fuel management and closed nuclear fuel cycle

International Nuclear Information System (INIS)

Kudryavtsev, E.G.

2012-01-01

Strategic objectives set by Rosatom Corporation in the field of spent fuel management are given. By 2030, Russia is to create technological infrastructure for innovative nuclear energy development, including complete closure of the nuclear fuel cycle. A target model of the spent NPP nuclear fuel management system until 2030 is analyzed. The schedule for key stages of putting in place the infrastructure for spent NPP fuel management is given. The financial aspect of the problem is also discussed [ru

Nuclear fuel assembly

International Nuclear Information System (INIS)

Hayashi, Hiroshi; Watari, Yoshio; Hizahara, Hiroshi; Masuoka, Ryuzo.

1970-01-01

When exchanging nuclear fuel assemblies during the operation of a nuclear reactor, melting of fuel bodies, and severence of tubular claddings is halted at the time of insertion by furnishing a neutron absorbing material such as B 10 , Cd, Gd or the like at the forward end of the fuel assembly to thereby lower the power peak at the forward ends of the fuel elements to within tolerable levels and thus prevent both fuel liquification and excessive expansion. The neutron absorbing material may be attached in the form of a plate to the fuel assembly forward tie plate, or may be inserted as a pellet into the front end of the tubular cladding. (Owens, K.J.)

Regulation at nuclear fuel cycle

International Nuclear Information System (INIS)

2002-01-01

This bulletin contains information about activities of the Nuclear Regulatory Authority of the Slovak Republic (UJD). In this leaflet the role of the UJD in regulation at nuclear fuel cycle is presented. The Nuclear Fuel Cycle (NFC) is a complex of activities linked with production of nuclear fuel for nuclear reactors as a source of energy used for production of electricity and heat, and of activities linked with spent nuclear fuel handling. Activities linked with nuclear fuel (NF) production, known as the Front-End of Nuclear Fuel Cycle, include (production of nuclear fuel from uranium as the most frequently used element). After discharging spent nuclear fuel (SNF) from nuclear reactor the activities follow linked with its storage, reprocessing and disposal known as the Back-End of Nuclear Fuel Cycle. Individual activity, which penetrates throughout the NFC, is transport of nuclear materials various forms during NF production and transport of NF and SNF. Nuclear reactors are installed in the Slovak Republic only in commercial nuclear power plants and the NFC is of the open type is imported from abroad and SNF is long-term supposed without reprocessing. The main mission of the area of NFC is supervision over: - assurance of nuclear safety throughout all NFC activities; - observance of provisions of the Treaty on Non-Proliferation of Nuclear Weapons during nuclear material handling; with an aim to prevent leakage of radioactive substances into environment (including deliberated danage of NFC sensitive facilities and misuse of nuclear materials to production of nuclear weapons. The UJD carries out this mission through: - assessment of safety documentation submitted by operators of nuclear installations at which nuclear material, NF and SNF is handled; - inspections concentrated on assurance of compliance of real conditions in NFC, i.e. storage and transport of NF and SNF; storage, transport and disposal of wastes from processing of SNF; with assumptions of the safety

Nuclear safeguards and export controls

International Nuclear Information System (INIS)

Mueller, H.

1994-01-01

Precisely from the perspective of the two most important nonnuclear weapons states, Japan and Germany, the safeguards and arms control agendas have not been finally dealt with. Because of their central position in the nonproliferation regime as nuclear suppliers and states with large nuclear energy industries, both countries are compelled to take a leading role in pursuing future reforms. In the dialogue with the nonaligned, this leadership position is helped by their nonnuclear status. In fact, Japan and Germany have some interests in common with the nonaligned states, such as the expansion of safeguards in the nuclear weapons states. To be sure, both Japan and Germany will pursue such interests with due regard to the interests of their friends and allies. For Japan, maintaining a close relationship with the United States is as important as shaping viable relations with China. Initiatives and controversies on nuclear policy must be weighed against this interest. By the same token, Germany must take into account the dense network of relations with its allies and with Russia, in addition to the German-French friendship. This will always set limits to Germany's readiness to confront the nuclear weapons states on nuclear issues. This, however, does not mean that both countries must shut up when the P 5 speak. The nuclear weapons register and the extension of the ''erga omnes'' rule in export controls, for example, should not be relegated to the dustbin of history, just because some friendly nuclear powers don't like these ideas. (orig.)

Characterization of the ptr5{sup +} gene involved in nuclear mRNA export in fission yeast

Energy Technology Data Exchange (ETDEWEB)

Watanabe, Nobuyoshi; Ikeda, Terumasa; Mizuki, Fumitaka [Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, Kurokami, Kumamoto 860-8555 (Japan); Tani, Tokio, E-mail: ttani@sci.kumamoto-u.ac.jp [Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, Kurokami, Kumamoto 860-8555 (Japan)

2012-02-03

Highlights: Black-Right-Pointing-Pointer We cloned the ptr5{sup +} gene involved in nuclear mRNA export in fission yeast. Black-Right-Pointing-Pointer The ptr5{sup +} gene was found to encode nucleoporin 85 (Nup85). Black-Right-Pointing-Pointer Seh1p and Mlo3p are multi-copy suppressors for the ptr5 mutation. Black-Right-Pointing-Pointer Ptr5p/Nup85p functions in nuclear mRNA export through the mRNA export factor Rae1p. Black-Right-Pointing-Pointer Ptr5p/Nup85p interacts genetically with pre-mRNA splicing factors. -- Abstract: To analyze the mechanisms of mRNA export from the nucleus to the cytoplasm, we have isolated eleven mutants, ptr [poly(A){sup +} RNA transport] 1 to 11, which accumulate poly(A){sup +} RNA in the nucleus at a nonpermissive temperature in Schizosaccharomyces pombe. Of those, the ptr5-1 mutant shows dots- or a ring-like accumulation of poly(A){sup +} RNA at the nuclear periphery after shifting to the nonpermissive temperature. We cloned the ptr5{sup +} gene and found that it encodes a component of the nuclear pore complex (NPC), nucleoporin 85 (Nup85). The ptr5-1 mutant shows no defects in protein transport, suggesting the specific involvement of Ptr5p/Nup85p in nuclear mRNA export in S. pombe. We identified Seh1p, a nucleoporin interacting with Nup85p, an mRNA-binding protein Mlo3p, and Sac3p, a component of the TREX-2 complex involved in coupling of nuclear mRNA export with transcription, as multi-copy suppressors for the ptr5-1 mutation. In addition, we found that the ptr5-1 mutation is synthetically lethal with a mutation of the mRNA export factor Rae1p, and that the double mutant exaggerates defective nuclear mRNA export, suggesting that Ptr5p/Nup85p is involved in nuclear mRNA export through Rae1p. Interestingly, the ptr5-1 mutation also showed synthetic effects with several prp pre-mRNA splicing mutations, suggesting a functional linkage between the NPCs and the splicing apparatus in the yeast nucleus.

Government experience in nuclear power plant export financing

International Nuclear Information System (INIS)

Kalbitz, K.

1976-01-01

Because the long-term funds at the disposal of the commercial banks were insufficient to make available the amounts required for the exportation of nuclear power plants, it was necessary to make available long-term funds of the mortgage banks. On account of the strict regulations governing the lending operations of such banks, it was, however, necessary to introduce a Federal guarantee which covers 100% of the contract value in each case. On balance, however, the Federal Government does not take over any additional risks, because recourse may be taken to the commercial banks, which are liable for all additional payments under the credit arrangement having arisen from the improvement of the guarantee in favour of the mortgage banks. This has resulted in a considerable improvement of the export financing system which, of course, is for benefit of other major export projects too. (HP) [de

Method of manufacturing nuclear fuel pellet

International Nuclear Information System (INIS)

Oguma, Masaomi; Masuda, Hiroshi; Hirai, Mutsumi; Tanabe, Isami; Yuda, Ryoichi.

1989-01-01

In a method of manufacturing nuclear fuel pellets by compression molding an oxide powder of nuclear fuel material followed by sintering, a metal nuclear material is mixed with an oxide powder of the nuclear fuel material. As the metal nuclear fuel material, whisker or wire-like fine wire or granules of metal uranium can be used effectively. As a result, a fuel pellet in which the metal nuclear fuel is disposed in a network-like manner can be obtained. The pellet shows a great effect of preventing thermal stress destruction of pellets upon increase of fuel rod power as compared with conventional pellets. Further, the metal nuclear fuel material acts as an oxygen getter to suppress the increase of O/M ratio of the pellets. Further, it is possible to reduce the swelling of pellet at high burn-up degree. (T.M.)

Nuclear fuel banks

International Nuclear Information System (INIS)

Anon.

2010-01-01

In december 2010 IAEA gave its agreement for the creation of a nuclear fuel bank. This bank will allow IAEA to help member countries that renounce to their own uranium enrichment capacities. This bank located on one or several member countries will belong to IAEA and will be managed by IAEA and its reserve of low enriched uranium will be sufficient to fabricate the fuel for the first load of a 1000 MW PWR. Fund raising has been successful and the running of the bank will have no financial impact on the regular budget of the IAEA. Russia has announced the creation of the first nuclear fuel bank. This bank will be located on the Angarsk site (Siberia) and will be managed by IAEA and will own 120 tonnes of low-enriched uranium fuel (between 2 and 4.95%), this kind of fuel is used in most Russian nuclear power plants. (A.C.)

Questionnaire used and responses obtained by sub-group 1C on the subject of the impact of national policies and constraints on nuclear fuel exploration, marketing and assurance of supply

International Nuclear Information System (INIS)

Information on existing national policies and incentives for uranium and thorium exploration, mining, export, import and stockpiling of nuclear fuel and measures which are being adopted to promote nuclear industries is presented

South Korea's nuclear fuel industry

International Nuclear Information System (INIS)

Clark, R.G.

1990-01-01

March 1990 marked a major milestone for South Korea's nuclear power program, as the country became self-sufficient in nuclear fuel fabrication. The reconversion line (UF 6 to UO 2 ) came into full operation at the Korea Nuclear Fuel Company's fabrication plant, as the last step in South Korea's program, initiated in the mid-1970s, to localize fuel fabrication. Thus, South Korea now has the capability to produce both CANDU and pressurized water reactor (PWR) fuel assemblies. This article covers the nuclear fuel industry in South Korea-how it is structures, its current capabilities, and its outlook for the future

Late Maturation Steps Preceding Selective Nuclear Export and Egress of Progeny Parvovirus.

Science.gov (United States)

Wolfisberg, Raphael; Kempf, Christoph; Ros, Carlos

2016-06-01

Although the mechanism is not well understood, growing evidence indicates that the nonenveloped parvovirus minute virus of mice (MVM) may actively egress before passive release through cell lysis. We have dissected the late maturation steps of the intranuclear progeny with the aims of confirming the existence of active prelytic egress and identifying critical capsid rearrangements required to initiate the process. By performing anion-exchange chromatography (AEX), we separated intranuclear progeny particles by their net surface charges. Apart from empty capsids (EC), two distinct populations of full capsids (FC) arose in the nuclei of infected cells. The earliest population of FC to appear was infectious but, like EC, could not be actively exported from the nucleus. Further maturation of this early population, involving the phosphorylation of surface residues, gave rise to a second, late population with nuclear export potential. While capsid surface phosphorylation was strictly associated with nuclear export capacity, mutational analysis revealed that the phosphoserine-rich N terminus of VP2 (N-VP2) was dispensable, although it contributed to passive release. The reverse situation was observed for the incoming particles, which were dephosphorylated in the endosomes. Our results confirm the existence of active prelytic egress and reveal a late phosphorylation event occurring in the nucleus as a selective factor for initiating the process. In general, the process of egress of enveloped viruses is active and involves host cell membranes. However, the release of nonenveloped viruses seems to rely more on cell lysis. At least for some nonenveloped viruses, an active process before passive release by cell lysis has been reported, although the underlying mechanism remains poorly understood. By using the nonenveloped model parvovirus minute virus of mice, we could confirm the existence of an active process of nuclear export and further characterize the associated capsid

Dissolving method for nuclear fuel oxide

International Nuclear Information System (INIS)

Tomiyasu, Hiroshi; Kataoka, Makoto; Asano, Yuichiro; Hasegawa, Shin-ichi; Takashima, Yoichi; Ikeda, Yasuhisa.

1996-01-01

In a method of dissolving oxides of nuclear fuels in an aqueous acid solution, the oxides of the nuclear fuels are dissolved in a state where an oxidizing agent other than the acid is present together in the aqueous acid solution. If chlorate ions (ClO 3 - ) are present together in the aqueous acid solution, the chlorate ions act as a strong oxidizing agent and dissolve nuclear fuels such as UO 2 by oxidation. In addition, a Ce compound which generates Ce(IV) by oxidation is added to the aqueous acid solution, and an ozone (O 3 ) gas is blown thereto to dissolve the oxides of nuclear fuels. Further, the oxides of nuclear fuels are oxidized in a state where ClO 2 is present together in the aqueous acid solution to dissolve the oxides of nuclear fuels. Since oxides of the nuclear fuels are dissolved in a state where the oxidizing agent is present together as described above, the oxides of nuclear fuels can be dissolved even at a room temperature, thereby enabling to use a material such as polytetrafluoroethylene and to dissolve the oxides of nuclear fuels at a reduced cost for dissolution. (T.M.)

Plutonium, power, and politics: international arrangements for the disposition of spent nuclear fuel

International Nuclear Information System (INIS)

Rochlin, G.I.

1979-01-01

In this study, Gene Rochlin, physicist and social scientist, explores the technical, political, and institutional aspects of international nuclear export and fuel-cycle policies. He categorizes existing proposals and suggests ways to develop new ones that better promote both national and international goals. Dr. Rochlin argues neither for nor against the future use of nuclear power or plutonium fuels. Rather, he addresses the question of how international arrangements could be reached that might jointly satisfy the objectives of the several key nations, yet not be too difficult to negotiate. He concludes that a major fault has been the tendency to improvise arrangements for specific technical or industrial operations. As a result, overall social and political goals have become the bargaining points for compromise. Yet, attempts to simultaneously resolve all problems are unlikely to prove fruitful. Dr. Rochlin suggests instead the formation of institutions organized around more-limited social, political, and technical objectives - even at the expense of excluding some nations, or omitting some aspects of the nuclear fuel cycle. Only by so doing, he argues, can immediate agreements be reached that preserve the potential for more-comprehensive future arrangements without sacrificing industrial, environmental, or nonproliferation goals

Nuclear fuels policy. Report of the Atlantic Council's Nuclear Fuels Policy Working Group

International Nuclear Information System (INIS)

Anon.

1976-01-01

This Policy Paper recommends the actions deemed necessary to assure that future U.S. and non-Communist countries' nuclear fuels supply will be adequate, considering the following: estimates of modest growth in overall energy demand, electrical energy demand, and nuclear electrical energy demand in the U.S. and abroad, predicated upon the continuing trends involving conservation of energy, increased use of electricity, and moderate economic growth (Chap. I); possibilities for the development and use of all domestic resources providing energy alternatives to imported oil and gas, consonant with current environmental, health, and safety concerns (Chap. II); assessment of the traditional energy sources which provide current alternatives to nuclear energy (Chap. II); evaluation of realistic expectations for additional future energy supplies from prospective technologies: enhanced recovery from traditional sources and development and use of oil shales and synthetic fuels from coal, fusion and solar energy (Chap. II); an accounting of established nuclear technology in use today, in particular the light water reactor, used for generating electricity (Chap. III); an estimate of future nuclear technology, in particular the prospective fast breeder (Chap. IV); current and projected nuclear fuel demand and supply in the U.S. and abroad (Chaps. V and VI); the constraints encountered today in meeting nuclear fuels demand (Chap. VII); and the major unresolved issues and options in nuclear fuels supply and use (Chap. VIII). The principal conclusions and recommendations (Chap. IX) are that the U.S. and other industrialized countries should strive for increased flexibility of primary energy fuel sources, and that a balanced energy strategy therefore depends on the secure supply of energy resources and the ability to substitute one form of fuel for another

Quality management of nuclear fuel

International Nuclear Information System (INIS)

2006-01-01

The Guide presents the quality management requirements to be complied with in the procurement, design, manufacture, transport, receipt, storage, handling and operation of nuclear fuel. The Guide also applies to control rods and shield elements to be placed in the reactor. The Guide is mainly aimed for the licensee responsible for the procurement and operation of fuel, for the fuel designer and manufacturer and for other organisations, whose activities affect fuel quality and the safety of fuel transport, storage and operation. General requirements for nuclear fuel are presented in Section 114 of the Finnish Nuclear Energy Decree and in Section 15 of the Government Decision (395/1991). Regulatory control of the safety of fuel is described in Guides YVL6.1, YVL6.2 and YVL6.3. An overview of the regulatory control of nuclear power plants carried out by STUK (Radiation and Nuclear Safety Authority, Finland) is clarified in Guide YVL1.1

Spent nuclear fuel storage device and spent nuclear fuel storage method using the device

International Nuclear Information System (INIS)

Tani, Yutaro

1998-01-01

Storage cells attachably/detachably support nuclear fuel containing vessels while keeping the vertical posture of them. A ventilation pipe which forms air channels for ventilating air to the outer circumference of the nuclear fuel containing vessel is disposed at the outer circumference of the nuclear fuel containing vessel contained in the storage cell. A shielding port for keeping the support openings gas tightly is moved, and a communication port thereof can be aligned with the upper portion of the support opening. The lower end of the transporting and containing vessel is placed on the shielding port, and an opening/closing shutter is opened. The gas tightness is kept by the shielding port, the nuclear fuel containing vessel filled with spent nuclear fuels is inserted to the support opening and supported. Then, the support opening is closed by a sealing lid. (I.N.)

Nuclear fuels accounting interface: River Bend experience

International Nuclear Information System (INIS)

Barry, J.E.

1986-01-01

This presentation describes nuclear fuel accounting activities from the perspective of nuclear fuels management and its interfaces. Generally, Nuclear Fuels-River Bend Nuclear Group (RBNG) is involved on a day-by-day basis with nuclear fuel materials accounting in carrying out is procurement, contract administration, processing, and inventory management duties, including those associated with its special nuclear materials (SNM)-isotopics accountability oversight responsibilities as the Central Accountability Office for the River Bend Station. As much as possible, these duties are carried out in an integrated, interdependent manner. From these primary functions devolve Nuclear Fuels interfacing activities with fuel cost and tax accounting. Noting that nuclear fuel tax accounting support is of both an esoteric and intermittent nature, Nuclear Fuels-RBNG support of developments and applications associated with nuclear fuel cost accounting is stressed in this presentation

Nuclear Export Control Policy in Korea - Present and future

International Nuclear Information System (INIS)

Kim, Jongsook

2008-01-01

The International community has been facing with the continued challenges for possession and proliferation of WMD over the past years. In addition, it is known that the terrorist groups are interested in acquiring WMD. The black market of WMD related materials and technologies show also the one of seriousness of our challenges. A number of international treaties, agreements and initiatives to control the proliferation of weapons of N, B, C and their delivery system have been existed to deal with these challenges, but their missions are challenged greatly in recent a series of nuclear issues by Iran and North Korea. The paper reviews the current international export control status and Korea export control system and policy. It also addresses some agenda to be done as future export control policy in Korea

Advances in nuclear fuel technology. 3. Development of advanced nuclear fuel recycle systems

International Nuclear Information System (INIS)

Arie, Kazuo; Abe, Tomoyuki; Arai, Yasuo

2002-01-01

Fast breeder reactor (FBR) cycle technology has a technical characteristics flexibly easy to apply to diverse fuel compositions such as plutonium, minor actinides, and so on and fuel configurations. By using this characteristics, various feasibilities on effective application of uranium resources based on breeding of uranium of plutonium for original mission of FBR, contribution to radioactive wastes problems based on amounts reduction of transuranium elements (TRU) in high level radioactive wastes, upgrading of nuclear diffusion resistance, extremely upgrading of economical efficiency, and so on. In this paper, were introduced from these viewpoints, on practice strategy survey study on FBR cycle performed by cooperation of the Japan Nuclear Cycle Development Institute (JNC) with electric business companies and so on, and on technical development on advanced nuclear fuel recycle systems carried out at the Central Research Institute of Electric Power Industry, Japan Atomic Energy Research Institute, and so on. Here were explained under a vision on new type of fuels such as nitride fuels, metal fuels, and so on as well as oxide fuels, a new recycle system making possible to use actinides except uranium and plutonium, an 'advanced nuclear fuel cycle technology', containing improvement of conventional wet Purex method reprocessing technology, fuel manufacturing technology, and so on. (G.K.)

Nuclear export signal of PRRSV NSP1α is necessary for type I IFN inhibition

International Nuclear Information System (INIS)

Chen, Zhi; Liu, Shaoning; Sun, Wenbo; Chen, Lei; Yoo, Dongwan; Li, Feng; Ren, Sufang; Guo, Lihui; Cong, Xiaoyan; Li, Jun; Zhou, Shun; Wu, Jiaqiang

2016-01-01

The nonstructural protein 1α (NSP1α) of porcine reproductive and respiratory syndrome virus (PRRSV) is a nucleo-cytoplasmic protein that suppresses the production of type I interferon (IFN). In this study, we investigated the relationship between the subcellular distribution of NSP1α and its inhibition of type I IFN. NSP1α was found to contain the classical nuclear export signal (NES) and NSP1α nuclear export was CRM-1-mediated. NSP1α was shuttling between the nucleus and cytoplasm. We also showed that the nuclear export of NSP1α was necessary for its ability for type I IFN inhibition. NSP1α was also found to interact with CBP, which implies a possible mechanism of CBP degradation by NSP1α. Taken together, our results describe a novel mechanism of PRRSV NSP1α for type I IFN inhibition and suppression of the host innate antiviral response. - Highlights: •NSP1α contains the NES and NSP1α nuclear export was CRM-1-mediated. •NSP1α was shuttling between the nucleus and cytoplasm continuously. •The nuclear export of NSP1α was necessary for its ability for type I IFN inhibition. •NSP1α interacts with CBP, which implies the mechanism of CBP degradation by NSP1α.

Nuclear export signal of PRRSV NSP1α is necessary for type I IFN inhibition

Energy Technology Data Exchange (ETDEWEB)

Chen, Zhi [Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road No. 8, Jinan 250100 (China); Liu, Shaoning [Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road No. 8, Jinan 250100 (China); Shandong Institute of Veterinary Drug Quality Inspection, Shandong Key Laboratory for Quality Safety Monitoring and Risk Assessment of Animal Products, Huaicun Street No. 68, Jinan 250722, Shandong Province (China); Sun, Wenbo; Chen, Lei [Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road No. 8, Jinan 250100 (China); Yoo, Dongwan [Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Ave, Urbana, IL 61802 (United States); Li, Feng [Department of Biology and Microbiology, Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007 (United States); Ren, Sufang; Guo, Lihui; Cong, Xiaoyan; Li, Jun [Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road No. 8, Jinan 250100 (China); Zhou, Shun [College of marine science and engineering, Qingdao Agricultural University, Changcheng Road No. 700, Qingdao 266109 (China); Wu, Jiaqiang, E-mail: wujiaqiang2000@sina.com [Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road No. 8, Jinan 250100 (China); and others

2016-12-15

The nonstructural protein 1α (NSP1α) of porcine reproductive and respiratory syndrome virus (PRRSV) is a nucleo-cytoplasmic protein that suppresses the production of type I interferon (IFN). In this study, we investigated the relationship between the subcellular distribution of NSP1α and its inhibition of type I IFN. NSP1α was found to contain the classical nuclear export signal (NES) and NSP1α nuclear export was CRM-1-mediated. NSP1α was shuttling between the nucleus and cytoplasm. We also showed that the nuclear export of NSP1α was necessary for its ability for type I IFN inhibition. NSP1α was also found to interact with CBP, which implies a possible mechanism of CBP degradation by NSP1α. Taken together, our results describe a novel mechanism of PRRSV NSP1α for type I IFN inhibition and suppression of the host innate antiviral response. - Highlights: •NSP1α contains the NES and NSP1α nuclear export was CRM-1-mediated. •NSP1α was shuttling between the nucleus and cytoplasm continuously. •The nuclear export of NSP1α was necessary for its ability for type I IFN inhibition. •NSP1α interacts with CBP, which implies the mechanism of CBP degradation by NSP1α.

Nuclear fuel strategies

International Nuclear Information System (INIS)

Rippon, S.

1989-01-01

The paper reports on two international meetings on nuclear fuel strategies, one organised by the World Nuclear Fuel Market in Seville (Spain) October 1988, and the other organised by the American and European nuclear societies in Washington (U.S.A.) November 1988. At the Washington meeting a description was given of the uranium supply and demand market, whereas free trade in uranium was considered in Seville. Considerable concern was expressed at both meetings on the effect on the uranium and enrichment services market of very low prices for spot deals being offered by China and the Soviet Union. Excess enrichment capacity, the procurement policies of the USA and other countries, and fuel cycle strategies, were also discussed. (U.K.)

Transportation of spent nuclear fuels

International Nuclear Information System (INIS)

Meguro, Toshiichi

1976-01-01

The spent nuclear fuel taken out of reactors is cooled in the cooling pool in each power station for a definite time, then transported to a reprocessing plant. At present, there is no reprocessing plant in Japan, therefore the spent nuclear fuel is shipped abroad. In this paper, the experiences and the present situation in Japan are described on the transport of the spent nuclear fuel from light water reactors, centering around the works in Tsuruga Power Station, Japan Atomic Power Co. The spent nuclear fuel in Tsuruga Power Station was first transported in Apr. 1973, and since then, about 36 tons were shipped to Britain by 5 times of transport. The reprocessing plant in Japan is expected to start operation in Apr. 1977, accordingly the spent nuclear fuel used for the trial will be transported in Japan in the latter half of this year. Among the permission and approval required for the transport of spent nuclear fuel, the acquisition of the certificate for transport casks and the approval of land and sea transports are main tasks. The relevant laws are the law concerning the regulations of nuclear raw material, nuclear fuel and reactors and the law concerning the safety of ships. The casks used in Tsuruga Power Station and EXL III type, and the charging of spent nuclear fuel, the decontamination of the casks, the leak test, land transport with a self-running vehicle, loading on board an exclusive carrier and sea transport are briefly explained. The casks and the ship for domestic transport are being prepared. (Kato, I.)

Romanian nuclear fuel cycle development

International Nuclear Information System (INIS)

Rapeanu, S.N.; Comsa, Olivia

1998-01-01

Romanian decision to introduce nuclear power was based on the evaluation of electricity demand and supply as well as a domestic resources assessment. The option was the introduction of CANDU-PHWR through a license agreement with AECL Canada. The major factors in this choice have been the need of diversifying the energy resources, the improvement the national industry and the independence of foreign suppliers. Romanian Nuclear Power Program envisaged a large national participation in Cernavoda NPP completion, in the development of nuclear fuel cycle facilities and horizontal industry, in R and D and human resources. As consequence, important support was being given to development of industries involved in Nuclear Fuel Cycle and manufacturing of equipment and nuclear materials based on technology transfer, implementation of advanced design execution standards, QA procedures and current nuclear safety requirements at international level. Unit 1 of the first Romanian nuclear power plant, Cernavoda NPP with a final profile 5x700 Mw e, is now in operation and its production represents 10% of all national electricity production. There were also developed all stages of FRONT END of Nuclear Fuel Cycle as well as programs for spent fuel and waste management. Industrial facilities for uranian production, U 3 O 8 concentrate, UO 2 powder and CANDU fuel bundles, as well as heavy water plant, supply the required fuel and heavy water for Cernavoda NPP. The paper presents the Romanian activities in Nuclear Fuel Cycle and waste management fields. (authors)

Adducin family proteins possess different nuclear export potentials.

Science.gov (United States)

Liu, Chia-Mei; Hsu, Wen-Hsin; Lin, Wan-Yi; Chen, Hong-Chen

2017-05-10

The adducin (ADD) family proteins, namely ADD1, ADD2, and ADD3, are actin-binding proteins that play important roles in the stabilization of membrane cytoskeleton and cell-cell junctions. All the ADD proteins contain a highly conserved bipartite nuclear localization signal (NLS) at the carboxyl termini, but only ADD1 can localize to the nucleus. The reason for this discrepancy is not clear. To avoid the potential effect of cell-cell junctions on the distribution of ADD proteins, HA epitope-tagged ADD proteins and mutants were transiently expressed in NIH3T3 fibroblasts and their distribution in the cytoplasm and nucleus was examined by immunofluorescence staining. Several nuclear proteins were identified to interact with ADD1 by mass spectrometry, which were further verified by co-immunoprecipitation. In this study, we found that ADD1 was detectable both in the cytoplasm and nucleus, whereas ADD2 and ADD3 were detected only in the cytoplasm. However, ADD2 and ADD3 were partially (~40%) sequestered in the nucleus by leptomycin B, a CRM1/exportin1 inhibitor. Upon the removal of leptomycin B, ADD2 and ADD3 re-distributed to the cytoplasm. These results indicate that ADD2 and ADD3 possess functional NLS and are quickly transported to the cytoplasm upon entering the nucleus. Indeed, we found that ADD2 and ADD3 possess much higher potential to counteract the activity of the NLS derived from Simian virus 40 large T-antigen than ADD1. All the ADD proteins appear to contain multiple nuclear export signals mainly in their head and neck domains. However, except for the leucine-rich motif ( 377 FEALMRMLDWLGYRT 391 ) in the neck domain of ADD1, no other classic nuclear export signal was identified in the ADD proteins. In addition, the nuclear retention of ADD1 facilitates its interaction with RNA polymerase II and zinc-finger protein 331. Our results suggest that ADD2 and ADD3 possess functional NLS and shuttle between the cytoplasm and nucleus. The discrepancy in the

Romanian nuclear fuel fabrication and in-reactor fuel operational experience

International Nuclear Information System (INIS)

Budan, O.

2003-01-01

A review of the Romanian nuclear program since mid 60's is made. After 1990, the new Romanian nuclear power authority, RENEL-GEN, elaborated a realistic Nuclear Fuel Program. This program went through the Romanian nuclear fuel plant qualification with the Canadian (AECL and ZPI) support, restarting in January 1995 of the industrial nuclear fuel production, quality evaluation of the fuel produced before 1990 and the recovery of this fuel. This new policy produced good results. FCN is since 1995 the only CANDU fuel supplier from outside Canada recognised by AECL as an authorised CANDU fuel manufacturer. The in-reactor performances and behaviour of the fuel manufactured by FCN after its qualification have been excellent. Very low - more then five times lesser than the design value - fuel defect rate has been recorded up to now and the average discharge of this fuel was with about 9% greater than the design value. Since mid 1998 when SNN took charge of the production of nuclear generated electricity, FCN made significant progresses in development and procurement of new and more efficient equipment and is now very close to double its fuel production capacity. After the completion of the recovery of the fuel produced before June 1990, FCN is already prepared to shift its fuel production to the so-called 'heavy' bundle containing about 19.3 kg of Uranium per bundle

Exportin-5 mediates nuclear export of SRP RNA in vertebrates.

Science.gov (United States)

Takeiwa, Toshihiko; Taniguchi, Ichiro; Ohno, Mutsuhito

2015-04-01

The signal recognition particle is a ribonucleoprotein complex that is essential for the translocation of nascent proteins into the endoplasmic reticulum. It has been shown that the RNA component (SRP RNA) is exported from the nucleus by CRM1 in the budding yeast. However, how SRP RNA is exported in higher species has been elusive. Here, we show that SRP RNA does not use the CRM1 pathway in Xenopus oocytes. Instead, SRP RNA uses the same export pathway as pre-miRNA and tRNA as showed by cross-competition experiments. Consistently, the recombinant Exportin-5 protein specifically stimulated export of SRP RNA as well as of pre-miRNA and tRNA, whereas an antibody raised against Exportin-5 specifically inhibited export of the same RNA species. Moreover, biotinylated SRP RNA can pull down Exportin-5 but not CRM1 from HeLa cell nuclear extracts in a RanGTP-dependent manner. These results, taken together, strongly suggest that the principal export receptor for SRP RNA in vertebrates is Exportin-5 unlike in the budding yeast. © 2015 The Authors. Genes to Cells published by Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd.

Nuclear reactors and fuel cycle

International Nuclear Information System (INIS)

2014-01-01

The Nuclear Fuel Center (CCN) of IPEN produces nuclear fuel for the continuous operation of the IEA-R1 research reactor of IPEN. The serial production started in 1988, when the first nuclear fuel element was delivered for IEA-R1. In 2011, CCN proudly presents the 100 th nuclear fuel element produced. Besides routine production, development of new technologies is also a permanent concern at CCN. In 2005, U 3 O 8 were replaced by U 3 Si 2 -based fuels, and the research of U Mo is currently under investigation. Additionally, the Brazilian Multipurpose Research Reactor (RMB), whose project will rely on the CCN for supplying fuel and uranium targets. Evolving from an annual production from 10 to 70 nuclear fuel elements, plus a thousand uranium targets, is a huge and challenging task. To accomplish it, a new and modern Nuclear Fuel Factory is being concluded, and it will provide not only structure for scaling up, but also a safer and greener production. The Nuclear Engineering Center has shown, along several years, expertise in the field of nuclear, energy systems and correlated areas. Due to the experience obtained during decades in research and technological development at Brazilian Nuclear Program, personnel has been trained and started to actively participate in design of the main system that will compose the Brazilian Multipurpose Reactor (RMB) which will make Brazil self-sufficient in production of radiopharmaceuticals. The institution has participated in the monitoring and technical support concerning the safety, licensing and modernization of the research reactors IPEN/MB-01 and IEA-R1. Along the last two decades, numerous specialized services of engineering for the Brazilian nuclear power plants Angra 1 and Angra 2 have been carried out. The contribution in service, research, training, and teaching in addition to the development of many related technologies applied to nuclear engineering and correlated areas enable the institution to fulfill its mission that is

Nuclear reactors and fuel cycle

Energy Technology Data Exchange (ETDEWEB)

NONE

2014-07-01

The Nuclear Fuel Center (CCN) of IPEN produces nuclear fuel for the continuous operation of the IEA-R1 research reactor of IPEN. The serial production started in 1988, when the first nuclear fuel element was delivered for IEA-R1. In 2011, CCN proudly presents the 100{sup th} nuclear fuel element produced. Besides routine production, development of new technologies is also a permanent concern at CCN. In 2005, U{sub 3}O{sub 8} were replaced by U{sub 3}Si{sub 2}-based fuels, and the research of U Mo is currently under investigation. Additionally, the Brazilian Multipurpose Research Reactor (RMB), whose project will rely on the CCN for supplying fuel and uranium targets. Evolving from an annual production from 10 to 70 nuclear fuel elements, plus a thousand uranium targets, is a huge and challenging task. To accomplish it, a new and modern Nuclear Fuel Factory is being concluded, and it will provide not only structure for scaling up, but also a safer and greener production. The Nuclear Engineering Center has shown, along several years, expertise in the field of nuclear, energy systems and correlated areas. Due to the experience obtained during decades in research and technological development at Brazilian Nuclear Program, personnel has been trained and started to actively participate in design of the main system that will compose the Brazilian Multipurpose Reactor (RMB) which will make Brazil self-sufficient in production of radiopharmaceuticals. The institution has participated in the monitoring and technical support concerning the safety, licensing and modernization of the research reactors IPEN/MB-01 and IEA-R1. Along the last two decades, numerous specialized services of engineering for the Brazilian nuclear power plants Angra 1 and Angra 2 have been carried out. The contribution in service, research, training, and teaching in addition to the development of many related technologies applied to nuclear engineering and correlated areas enable the institution to

Nuclear fuel element

International Nuclear Information System (INIS)

Mogard, J.H.

1977-01-01

A nuclear fuel element is disclosed for use in power producing nuclear reactors, comprising a plurality of axially aligned ceramic cylindrical fuel bodies of the sintered type, and a cladding tube of metal or metal alloys, wherein said cladding tube on its cylindrical inner surface is provided with a plurality of slightly protruding spacing elements distributed over said inner surface

Nuclear Fuel Cycle Objectives

International Nuclear Information System (INIS)

2013-01-01

. The four Objectives publications include Nuclear General Objectives, Nuclear Power Objectives, Nuclear Fuel Cycle Objectives, and Radioactive Waste management and Decommissioning Objectives. This publication sets out the objectives that need to be achieved in the area of the nuclear fuel cycle to ensure that the Nuclear Energy Basic Principles are satisfied. Within each of these four Objectives publications, the individual topics that make up each area are addressed. The five topics included in this publication are: resources; fuel engineering and performance; spent fuel management and reprocessing; fuel cycles; and the research reactor nuclear fuel cycle

Financing the nuclear fuel cycle

International Nuclear Information System (INIS)

Stephany, M.

1975-01-01

While conventional power stations usually have fossil fuel reserves for only a few weeks, nuclear power stations, because of the relatively long time required for uranium processing from ore extraction to the delivery of the fuel elements and their prolonged in-pile time, require fuel reserves for a period of several years. Although the specific fuel costs of nuclear power stations are much lower than those of conventional power stations, this results in consistently higher financial requirements. But the problems involved in financing the nuclear fuel do not only include the aspect of financing the requirements of reactor operators, but also of financing the facilities of the nuclear fuel cycle. As far as the fuel supply is concerned, the true financial requirements greatly exceed the mere purchasing costs because the costs of financing are rather high as a consequence of the long lead times. (orig./UA) [de

Improved moulding material for addition to nuclear fuel particles to produce nuclear fuel elements

International Nuclear Information System (INIS)

Miertschin, G.N.; Leary, D.F.

1976-01-01

A suggestion is made to improve the moulding materials used to produce carbon-contained nuclear fuel particles by a coke-reducing added substance. The nuclear fuel particles are meant for the formation of fuel elements for gas-cooled high-temperature nuclear reactors. The moulding materials are above all for the formation of coated particles which are burnt in situ in nuclear fuel element chambers out of 'green' nuclear fuel bodies. The added substance improves the shape stability of the particles forming and prevents a stiding or bridge formation between the particles or with the surrounding walls. The following are named as added substances: 1) Polystyrene and styrene-butadiene-Co polymers (mol. wt. between 5oo and 1,000,000), 2) aromatic compounds (mol. wt. 75 to 300), 3) saturated hydrocarbon polymers (mol. wt. 5,000 to 1,000,000). Additional release agents further improve the properties in the same direction (e.g. alcohols, fatty acids, amines). (orig.) [de

Nuclear proliferation

International Nuclear Information System (INIS)

Stencel, S.

1978-01-01

The terms and reactions to President Carter's nuclear policy, culminating in the 1978 Nuclear Non-Proliferation Act, are reviewed and analyzed. The new law increases restrictions on nuclear exports, encourages continued use of light water reactors in preference to plutonium-fueled reactors, and emphasizes technical solutions to proliferation problems. Critics of the law point out that it will hurt U.S. trade unfairly, that other countries do not have as many fuel options as the U.S. has, and that nuclear sales have as many political and economic as technical solutions. Compromise areas include new international safety guidelines, the possibility of an international nuclear fuel bank, and a willingness to consider each case on its merits. 21 references

Nuclear fuel assembly

International Nuclear Information System (INIS)

Wakamatsu, Mitsuo.

1974-01-01

Object: To improve a circulating flow passage of coolant so as to be able to accurately detect the temperature of coolant, rare gases contained, and the like. Structure: A fuel assembly comprising a flow regulating lattice provided with a plurality of communication holes in an axial direction, said lattice being positioned at the upper end of an outer tube in which nuclear fuel elements are received, and a neutron shielding body having a plurality of spiral coolant flow passages disposed between the lattice and the nuclear fuel elements, whereby a coolant comprised of liquid sodium or the like, which moves up passing through the coolant flow passages and the flow regulating passage, is regulated and passed through a detector mounted at the upper part of the flow regulating lattice to detect coolant temperature, flow rate, and rare gases or the like as the origin of nuclear fission contained in the coolant due to breakage of fuel elements. (Kamimura, M.)

Nuclear power and the nuclear fuel cycle

International Nuclear Information System (INIS)

Scurr, I.F.; Silver, J.M.

1990-01-01

Australian Nuclear Science and Technology Organization maintains an ongoing assessment of the world's nuclear technology developments, as a core activity of its Strategic Plan. This publication reviews the current status of the nuclear power and the nuclear fuel cycle in Australia and around the world. Main issues discussed include: performances and economics of various types of nuclear reactors, uranium resources and requirements, fuel fabrication and technology, radioactive waste management. A brief account of the large international effort to demonstrate the feasibility of fusion power is also given. 11 tabs., ills

Operation of Nuclear Fuel Based on Reprocessed Uranium for VVER-type Reactors in Competitive Nuclear Fuel Cycles

Energy Technology Data Exchange (ETDEWEB)

Troyanov, V.; Molchanov, V.; Tuzov, A. [TVEL Corporation, 49 Kashirskoe shosse, Moscow 115409 (Russian Federation); Semchenkov, Yu.; Lizorkin, M. [RRC ' Kurchatov Institute' (Russian Federation); Vasilchenko, I.; Lushin, V. [OKB ' Gidropress' (Russian Federation)

2009-06-15

Current nuclear fuel cycle of Russian nuclear power involves reprocessed low-enriched uranium in nuclear fuel production for some NPP units with VVER-type LWR. This paper discusses design and performance characteristics of commercial nuclear fuel based on natural and reprocessed uranium. It presents the review of results of commercial operation of nuclear fuel based on reprocessed uranium on Russian NPPs-unit No.2 of Kola NPP and unit No.2 of Kalinin NPP. The results of calculation and experimental validation of safe fuel operation including necessary isotope composition conformed to regulation requirements and results of pilot fuel operation are also considered. Meeting the customer requirements the possibility of high burn-up achieving was demonstrated. In addition the paper compares the characteristics of nuclear fuel cycles with maximum length based on reprocessed and natural uranium considering relevant 5% enrichment limitation and necessity of {sup 236}U compensation. The expedience of uranium-235 enrichment increasing over 5% is discussed with the aim to implement longer fuel cycles. (authors)

Nuclear fuel pellet charging device

International Nuclear Information System (INIS)

Komuro, Kojiro.

1990-01-01

The present invention concerns a nuclear fuel pellet loading device, in which nuclear fuel pellets are successively charged from an open end of a fuel can while rotating the can. That is, a fuel can sealed at one end with an end plug and opened at the other end is rotated around its pipe axis as the center on a rotationally diriving table. During rotation of the fuel can, nuclear fuel pellets are successively charged by means of a feed rod of a feeding device to the inside of the fuel can. The fuel can is rotated while being supported horizontally and the fuel pellets are charged from the open end thereof. Alternatively, the fuel can is rotated while being supported obliquely and the fuel pellets are charged gravitationally into the fuel can. In this way, the damages to the barrier of the fuel can can be reduce. Further, since the fuel pellets can be charged gravitationally by rotating the fuel can while being supported obliquely, the damages to the barrier can be reduced remarkably. (I.S.)

The status of nuclear fuel cycle system analysis for the development of advanced nuclear fuel cycles

Energy Technology Data Exchange (ETDEWEB)

Ko, Won Il; Kim, Seong Ki; Lee, Hyo Jik; Chang, Hong Rae; Kwon, Eun Ha; Lee, Yoon Hee; Gao, Fanxing [KAERI, Daejeon (Korea, Republic of)

2011-11-15

The system analysis has been used with different system and objectives in various fields. In the nuclear field, the system can be applied from uranium mining to spent fuel reprocessing or disposal which is called the nuclear fuel cycle. The analysis of nuclear fuel cycle can be guideline for development of advanced fuel cycle through integrating and evaluating the technologies. For this purpose, objective approach is essential and modeling and simulation can be useful. In this report, several methods which can be applicable for development of advanced nuclear fuel cycle, such as TRL, simulation and trade analysis were explained with case study

Nuclear reactor fuel element splitter

International Nuclear Information System (INIS)

Yeo, D.

1976-01-01

A method and apparatus are disclosed for removing nuclear fuel from a clad fuel element. The fuel element is power driven past laser beams which simultaneously cut the cladding lengthwise into at least two longitudinal pieces. The axially cut lengths of cladding are then separated, causing the nuclear fuel contained therein to drop into a receptacle for later disposition. The cut lengths of cladding comprise nuclear waste which is disposed of in a suitable manner. 6 claims, 10 drawing figures

Technical modifications and management innovations in exporting nuclear reactor projects

International Nuclear Information System (INIS)

Mao Xiaoming; Qin Xijiu; Ding Hu; Xue Zhaoqun; Wen Shengjun

2009-01-01

As a main channel for the foreign economic cooperation of China nuclear industry, China Zhongyuan Engineering Corporation (CZEC) has been constantly engaged in technical modifications and management innovations in its exporting nuclear reactor projects. In the implementation of heavy water research reactor contract in Algeria, CZEC had established a complete and adequate design standards system in compliance with the international standards, and made significant modifications to the reference reactor in the aspects of reactor power and reactor safety, solved quite some technical issues which-affected the reactor technical performance. The modifications and improvements enabled the technical parameters, safety features, reactor multipurpose application to attain to the advanced level in the world. In the 300 MWe PWR NPPs in Pakistan, safety features had been updated in line with upgrading regulatory requisites. The design philosophy and technology application demonstrated CZEC' s creation and innovation on basis of constant safety enhancement of nuclear power projects. Efforts had also been made by CZEC' s creation and innovation on basis of constant safety enhancement of nuclear power projects. Efforts had also been made by CZEC in promoting China made equipment items and components exportation. (authors)

Performing Free Radioactive Certificate as an Effort to Protect Import and Export Commodities in Globalization Era

International Nuclear Information System (INIS)

Kunto-Wiharto; Syarbaini

2001-01-01

Several activities such as nuclear weapon tests, nuclear fuel reprocessing and nuclear accidents have caused radioactive contamination in local, regional and global environment. In globalization and free trade era, every country will be faced to the condition with the movable commodities from and to another countries. Global contamination through import and export commodities is a problem will be found every country in the future. Therefore, performing free radioactive certification on import and export commodities must be carried out to protect a member of public and environment from radioactive contamination. (author)

Nuclear fuel elements

International Nuclear Information System (INIS)

Ainsworth, K.F.

1979-01-01

A nuclear fuel element is described having a cluster of nuclear fuel pins supported in parallel, spaced apart relationship by transverse cellular braces within coaxial, inner and outer sleeves, the inner sleeve being in at least two separate axial lengths, each of the transverse braces having a peripheral portion which is clamped peripherally between the ends of the axial lengths of the inner sleeve. (author)

A Path Forward to Advanced Nuclear Fuels: Spectroscopic Calorimetry of Nuclear Fuel Materials

International Nuclear Information System (INIS)

Tobin, J.G.

2009-01-01

The goal is to relieve the shortage of thermodynamic and kinetic information concerning the stability of nuclear fuel alloys. Past studies of the ternary nuclear fuel UPuZr have demonstrated constituent redistribution when irradiated or with thermal treatment. Thermodynamic data is key to predicting the possibilities of effects such as constituent redistribution within the fuel rods and interaction with cladding materials

Spent nuclear fuel disposal liability insurance

International Nuclear Information System (INIS)

Martin, D.W.

1984-01-01

This thesis examines the social efficiency of nuclear power when the risks of accidental releases of spent fuel radionuclides from a spent fuel disposal facility are considered. The analysis consists of two major parts. First, a theoretical economic model of the use of nuclear power including the risks associated with releases of radionuclides from a disposal facility is developed. Second, the costs of nuclear power, including the risks associated with a radionuclide release, are empirically compared to the costs of fossil fuel-fired generation of electricity. Under the provisions of the Nuclear Waste Policy Act of 1982, the federally owned and operated spent nuclear fuel disposal facility is not required to maintain a reserve fund to cover damages from an accidental radionuclide release. Thus, the risks of a harmful radionuclide release are not included in the spent nuclear fuel disposal fee charged to the electric utilities. Since the electric utilities do not pay the full, social costs of spent fuel disposal, they use nuclear fuel in excess of the social optimum. An insurance mechanism is proposed to internalize the risks associated with spent fueled disposal. Under this proposal, the Federal government is required to insure the disposal facility against any liabilities arising from accidental releases of spent fuel radionuclides

Nuclear fuel deformation phenomena

International Nuclear Information System (INIS)

Van Brutzel, L.; Dingreville, R.; Bartel, T.J.

2015-01-01

Nuclear fuel encounters severe thermomechanical environments. Its mechanical response is profoundly influenced by an underlying heterogeneous microstructure but also inherently dependent on the temperature and stress level histories. The ability to adequately simulate the response of such microstructures, to elucidate the associated macroscopic response in such extreme environments is crucial for predicting both performance and transient fuel mechanical responses. This chapter discusses key physical phenomena and the status of current modelling techniques to evaluate and predict fuel deformations: creep, swelling, cracking and pellet-clad interaction. This chapter only deals with nuclear fuel; deformations of cladding materials are discussed elsewhere. An obvious need for a multi-physics and multi-scale approach to develop a fundamental understanding of properties of complex nuclear fuel materials is presented. The development of such advanced multi-scale mechanistic frameworks should include either an explicit (domain decomposition, homogenisation, etc.) or implicit (scaling laws, hand-shaking,...) linkage between the different time and length scales involved, in order to accurately predict the fuel thermomechanical response for a wide range of operating conditions and fuel types (including Gen-IV and TRU). (authors)

IAEA activities on nuclear fuel cycle 1997

Energy Technology Data Exchange (ETDEWEB)

Oi, N [International Atomic Energy Agency, Vienna (Austria). Nuclear Fuel Cycle and Materials Section

1997-12-01

The presentation discussing the IAEA activities on nuclear fuel cycle reviews the following issues: organizational charts of IAEA, division of nuclear power and the fuel cycle, nuclear fuel cycle and materials section; 1997 budget estimates; budget trends; the nuclear fuel cycle programme.

IAEA activities on nuclear fuel cycle 1997

International Nuclear Information System (INIS)

Oi, N.

1997-01-01

The presentation discussing the IAEA activities on nuclear fuel cycle reviews the following issues: organizational charts of IAEA, division of nuclear power and the fuel cycle, nuclear fuel cycle and materials section; 1997 budget estimates; budget trends; the nuclear fuel cycle programme

Final report of the 2. committee of investigation of the 11. legislative period. Nuclear exports

International Nuclear Information System (INIS)

1990-01-01

On the subject of 'nuclear exports' the Committee dealt with political and legal principles of the Federal Government's nuclear export policy, particularly questions concerning the Non-Proliferation Treaty, and scientific-technical cooperation of the FRG with other countries, especially Argentina, Brazil, India, and Pakistan. Individual export transactions were then investigated, followed by a general assessment of the FRG's nuclear policy. - Concerning non-proliferation policy there have been certain administrative weaknesses in converting control measures into practice. Remedy is expected from the duty of terms to report deliveries punctually and completely and subsequent supervision. - The illegal transactions with India and Pakistan require improvements in the legal instruments, in the execution of administrative measures, and in border controls. Decisive steps have been introduced. (HSCH) [de

Exports of petroleum products, 1988

International Nuclear Information System (INIS)

1989-04-01

A summary is presented of exports of motor gasoline, middle distillate, aviation turbine fuel, heavy fuel oil, and partially processed oil from Canada for the 1988 calendar year. A discussion of petroleum product imports is included in order to put exports in the context of the overall trade. Exports of the above petroleum products averaged 32,000 m 3 /d in 1988, up 44% from 1987 levels. Each product except aviation fuel registered increases in export volumes, which reached the highest total volume of the decade. The main reason for the large increase was the first full year of production from the export-directed refinery at Come By Chance, Newfoundland. Export prices for light petroleum products stayed relatively close to USA spot prices. The heavy fuel oil price was mostly above the USA east coast spot price during 1988. Attractive prices on the USA east coast resulted in a few cargoes of middle distillate and motor gasoline shipped from British Columbia. Petroleum products imports came from 12 countries; Quebec had the largest volume of imports in 1988. The USA remained Canada's largest trading partner in petroleum products. Western exporters view the Far East as an ongoing important market. The top single exporter in Canada was Newfoundland Processing, with 32% of the total export volume. 12 figs., 3 tabs

Nuclear fuel rod loading apparatus

International Nuclear Information System (INIS)

King, H.B.

1981-01-01

A nuclear fuel loading apparatus, incorporating a microprocessor control unit, is described which automatically loads nuclear fuel pellets into dual fuel rods with a minimum of manual involvement and in a manner and sequence to ensure quality control and accuracy. (U.K.)

Experience with nuclear fuel utilization in Bulgaria

Energy Technology Data Exchange (ETDEWEB)

Harizanov, Y [Committee on the Use of Atomic Energy for Peaceful Purposes, Sofia (Bulgaria)

1997-12-01

The presentation on experience with nuclear fuel utilization in Bulgaria briefly reviews the situation with nuclear energy in Bulgaria and then discusses nuclear fuel performance (amount of fuel loaded, type of fuel, burnup, fuel failures, assemblies deformation). 2 tabs.

Nuclear fuel cycle information workshop

International Nuclear Information System (INIS)

1983-01-01

This overview of the nuclear fuel cycle is divided into three parts. First, is a brief discussion of the basic principles of how nuclear reactors work; second, is a look at the major types of nuclear reactors being used and world-wide nuclear capacity; and third, is an overview of the nuclear fuel cycle and the present industrial capability in the US

Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors

International Nuclear Information System (INIS)

Kiss, A.; Li, L.; Gettemeier, T.; Venkatesh, L.K.

2003-01-01

Human immunodeficiency virus type 1 (HIV-1) Rev-mediated nuclear export of viral RNAs involves the interaction of its leucine-rich nuclear export sequence (NES) with nuclear cofactors. In yeast two-hybrid screens of a human lymph node derived cDNA expression library, we identified the human nucleoporin Nup98 as a highly specific and potent interactor of the Rev NES. Using an extensive panel of nuclear export positive and negative mutants of the functionally homologous NESs of the HIV-1 Rev, human T cell leukemia virus type 1 (HTLV-1) Rex, and equine infectious anemia virus (EIAV) Rev proteins, physiologically significant interaction of hNup98 with the various NESs was demonstrated. Missense mutations in the yeast nuclear export factor Crm1p that abrogated Rev NES interaction with the XXFG repeat-containing nucleoporin, Rab/hRIP, had minimal effects on the interaction of GLFG repeat-containing hNup98. Functional analysis of Nup98 domains required for nuclear localization demonstrated that the entire ORF was required for efficient incorporation into the nuclear envelope. A putative nuclear localization signal was identified downstream of the GLFG repeat region. Whereas overexpression of both full-length Nup98 and the amino-terminal GLFG repeat region, but not the unique carboxy-terminal region, induced significant suppression of HIV unspliced RNA export, lower levels of exogenous Nup98 expression resulted in a relatively modest increase in unspliced RNA export. These results suggest a physiological role for hNup98 in modulating Rev-dependent RNA export during HIV infection

Improved nuclear fuel element

International Nuclear Information System (INIS)

Klepfer, H.H.

1974-01-01

A nuclear fuel element is described which comprises: 1) an elongated clad container, 2) a layer of high lubricity material being disposed in and adjacent to the clad container, 3) a low neutron capture cross section metal liner being disposed in the clad container and adjacent to the layer, 4) a central core of a body of nuclear fuel material disposed in and partially filling the container and forming an internal cavity in the container, 5) an enclosure integrally secured and sealed at each end of the container, and a nuclear fuel material retaining means positioned in the cavity. (author)

IAEA activities on nuclear fuel

International Nuclear Information System (INIS)

Basak, U.

2011-01-01

In this paper a brief description and the main objectives of IAEA Programme B on Nuclear fuel cycle are given. The following Coordinated Research Projects: 1) FUel performance at high burn-up and in ageing plant by management and optimisation of WAter Chemistry Technologies (FUWAC ); 2) Near Term and Promising Long Term Options for Deployment of Thorium Based Nuclear Energy; 3) Fuel Modelling (FUMEX-III) are shortly described. The data collected by the IAEA Expert Group of Fuel Failures in Water Cooled Reactors including information about fuel failure cause for PWR (1994-2006) and failure mechanisms for BWR fuel (1994-2006) are shown. The just published Fuel Failure Handbook as well as preparation of a Monograph on Zirconium including an overview of Zirconium for nuclear applications are presented. The current projects in Sub-programme B2 - Power Reactor Fuel Engineering are also listed

Future trends in nuclear fuels

International Nuclear Information System (INIS)

Guitierrez, J.E.

2006-01-01

This series of transparencies presents: the fuel management cycle and key areas (security of supplies, strategies and core management, reliability, spent fuel management), the world nuclear generating capacity, concentrate capacity, enrichment capacity, and manufacturing capacity forecasts, the fuel cycle strategies and core management (longer cycles, higher burnups, power up-rates, higher enrichments), the Spanish nuclear generation cost, the fuel reliability (no defects, robust designs, operational margins, integrated fuel and core design), spent fuel storage (design and safety criteria, fuel performance and integrity). (J.S.)

Mechanism for G2 phase-specific nuclear export of the kinetochore protein CENP-F.

Science.gov (United States)

Loftus, Kyle M; Cui, Heying; Coutavas, Elias; King, David S; Ceravolo, Amanda; Pereiras, Dylan; Solmaz, Sozanne R

2017-08-03

Centromere protein F (CENP-F) is a component of the kinetochore and a regulator of cell cycle progression. CENP-F recruits the dynein transport machinery and orchestrates several cell cycle-specific transport events, including transport of the nucleus, mitochondria and chromosomes. A key regulatory step for several of these functions is likely the G2 phase-specific export of CENP-F from the nucleus to the cytosol, where the cytoplasmic dynein transport machinery resides; however, the molecular mechanism of this process is elusive. Here, we have identified 3 phosphorylation sites within the bipartite classical nuclear localization signal (cNLS) of CENP-F. These sites are specific for cyclin-dependent kinase 1 (Cdk1), which is active in G2 phase. Phosphomimetic mutations of these residues strongly diminish the interaction of the CENP-F cNLS with its nuclear transport receptor karyopherin α. These mutations also diminish nuclear localization of the CENP-F cNLS in cells. Notably, the cNLS is phosphorylated in the -1 position, which is important to orient the adjacent major motif for binding into its pocket on karyopherin α. We propose that localization of CENP-F is regulated by a cNLS, and a nuclear export pathway, resulting in nuclear localization during most of interphase. In G2 phase, the cNLS is weakened by phosphorylation through Cdk1, likely resulting in nuclear export of CENP-F via the still active nuclear export pathway. Once CENP-F resides in the cytosol, it can engage in pathways that are important for cell cycle progression, kinetochore assembly and the faithful segregation of chromosomes into daughter cells.

The actin binding cytoskeletal protein Moesin is involved in nuclear mRNA export.

Science.gov (United States)

Kristó, Ildikó; Bajusz, Csaba; Borsos, Barbara N; Pankotai, Tibor; Dopie, Joseph; Jankovics, Ferenc; Vartiainen, Maria K; Erdélyi, Miklós; Vilmos, Péter

2017-10-01

Current models imply that the evolutionarily conserved, actin-binding Ezrin-Radixin-Moesin (ERM) proteins perform their activities at the plasma membrane by anchoring membrane proteins to the cortical actin network. Here we show that beside its cytoplasmic functions, the single ERM protein of Drosophila, Moesin, has a novel role in the nucleus. The activation of transcription by heat shock or hormonal treatment increases the amount of nuclear Moesin, indicating biological function for the protein in the nucleus. The distribution of Moesin in the nucleus suggests a function in transcription and the depletion of mRNA export factors Nup98 or its interacting partner, Rae1, leads to the nuclear accumulation of Moesin, suggesting that the nuclear function of the protein is linked to mRNA export. Moesin localizes to mRNP particles through the interaction with the mRNA export factor PCID2 and knock down of Moesin leads to the accumulation of mRNA in the nucleus. Based on our results we propose that, beyond its well-known, manifold functions in the cytoplasm, the ERM protein of Drosophila is a new, functional component of the nucleus where it participates in mRNA export. Copyright © 2017 Elsevier B.V. All rights reserved.

The fuel of nuclear reactors

International Nuclear Information System (INIS)

1995-03-01

This booklet is a presentation of the different steps of the preparation of nuclear fuels performed by Cogema. The documents starts with a presentation of the different French reactor types: graphite moderated reactors, PWRs using MOX fuel, fast breeder reactors and research reactors. The second part describes the fuel manufacturing process: conditioning of nuclear materials and fabrication of fuel assemblies. The third part lists the different companies involved in the French nuclear fuel industry while part 4 gives a short presentation of the two Cogema's fuel fabrication plants at Cadarache and Marcoule. Part 5 and 6 concern the quality assurance, the safety and reliability aspects of fuel elements and the R and D programs. The last part presents some aspects of the environmental and personnel protection performed by Cogema. (J.S.)

Strengthening the nuclear nonproliferation regime: focus on the civilian nuclear fuel cycle

International Nuclear Information System (INIS)

Saltiel, David H.; Pregenzer, Arian Leigh

2005-01-01

the century and could increase even more quickly. Much of the new demand will come from the rapidly expanding economies in China and India, but much of the developing world stands poised to follow the same path. This growth in demand is paralleled by concerns about global warming and the long-term reliability of carbon-based fuel supplies, concerns which expanded use of nuclear power can help to address. For these reasons and others, many countries in Asia have already clearly signaled that nuclear energy will play a key role for years to come. Numerous proposals have been made in the last two years for reducing the proliferation risk of the civilian nuclear fuel cycle. These range from a ban on export of enrichment and reprocessing technology to countries not already possessing operational capabilities to multinational management of the nuclear fuel cycle and strengthening existing monitoring and security mechanisms. The need for international willingness to enforce nonproliferation commitments and norms has also been emphasized. Some of these proposals could significantly impact the production of nuclear energy. Because the successful strengthening of the nonproliferation regime and the expansion of nuclear energy are so closely related, any successful approach to resolving these issues will require the creative input of experts from both the nuclear energy and nonproliferation communities. Against this backdrop, Sandia National Laboratories organized its 14th International Security Conference (ISC) around the theme: Strengthening the Nuclear Nonproliferation Regime: Focus on the Civilian Nuclear Fuel Cycle. The goal of the conference was to begin a constructive dialogue between the nuclear energy and nuclear nonproliferation communities. The conference was held in Chantilly, Virginia, just outside Washington, D.C. on April 4-6, 2005, and was attended by approximately 125 participants from fifteen countries. The ISC agenda was structured to produce a systematic

Availability of nuclear fuels: an aspect of supply assurance. [German Federal Republic

Energy Technology Data Exchange (ETDEWEB)

Dolinski, U; Ziesing, H J [Deutsches Inst. fuer Wirtschaftsforschung, Berlin (F.R. Germany)

1976-08-01

The future supply possibilities for the Federal Republic of Germany with nuclear fuel are investigated by the German Institute for Economy Research in an expertise on 'the safety, price and environmental aspects in the energy supply'. The requirements of natural uranium in the Federal Republic of Germany are dealt with, as well as the world-wide assured and probable deposits of natural uranium in relation to the extraction costs. After indicating the restrictive changes in the export policy of the supplying countries, the international and national state of development of recycling is shown.

Nuclear fuel cycle scenarios at CGNPC

International Nuclear Information System (INIS)

Xiao, Min; Zhou, Zhou; Nie, Li Hong; Mao, Guo Ping; Hao, Si Xiong; Shen, Kang

2008-01-01

Established in 1994, China Guangdong Nuclear Power Holding Co. (CGNPC) now owns two power stations GNPS and LNPS Phase I, with approximate 4000 MWe of installed capacity. With plant upgrades, advanced fuel management has been introduced into the two plants to improve the plant economical behavior with the high burnup fuel implemented. For the purpose of sustainable development, some preliminary studies on nuclear fuel cycle, especially on the back-end, have been carried out at CGNPC. According to the nuclear power development plan of China, the timing for operation and the capacity of the reprocessing facility are studied based on the amount of the spent fuel forecast in the future. Furthermore, scenarios of the fuel cycles in the future in China with the next generation of nuclear power were considered. Based on the international experiences on the spent fuel management, several options of spent fuel reprocessing strategies are investigated in detail, for example, MOX fuel recycling in light water reactor, especially in the current reactors of CGNPC, spent fuel intermediated storage, etc. All the investigations help us to draw an overall scheme of the nuclear fuel cycle, and to find a suitable road-map to achieve the sustainable development of nuclear power. (authors)

Reprocessing of spent nuclear fuel

International Nuclear Information System (INIS)

Kidd, S.

2008-01-01

The closed fuel cycle is the most sustainable approach for nuclear energy, as it reduces recourse to natural uranium resources and optimises waste management. The advantages and disadvantages of used nuclear fuel reprocessing have been debated since the dawn of the nuclear era. There is a range of issues involved, notably the sound management of wastes, the conservation of resources, economics, hazards of radioactive materials and potential proliferation of nuclear weapons. In recent years, the reprocessing advocates win, demonstrated by the apparent change in position of the USA under the Global Nuclear Energy Partnership (GNEP) program. A great deal of reprocessing has been going on since the fourties, originally for military purposes, to recover plutonium for weapons. So far, some 80000 tonnes of used fuel from commercial power reactors has been reprocessed. The article indicates the reprocessing activities and plants in the United Kigdom, France, India, Russia and USA. The aspect of plutonium that raises the ire of nuclear opponents is its alleged proliferation risk. Opponents of the use of MOX fuels state that such fuels represent a proliferation risk because the plutonium in the fuel is said to be 'weapon-use-able'. The reprocessing of used fuel should not give rise to any particular public concern and offers a number of potential benefits in terms of optimising both the use of natural resources and waste management.

Nuclear export and armament. New threats and peace perspectives

International Nuclear Information System (INIS)

Kubbig, B.W.; Mueller, H.

1993-02-01

The authors give a condensed analysis of safety and politico-economic dimensions regarding the further proliferation of nuclear weapons and carrier systems with which nuclear blasting charges can be transported. From the content: - Proliferation and non-proliferation: technology, economy and (international) law in a political historic survey. - Missile defense: appropriate technological answer to the political proliferation problem? -export strategies: USA and FRG in comparison, interest and policy of the European Community. - Components for an extensive proliferation strategy. (orig./HP) [de

Review of oxidation rates of DOE spent nuclear fuel : Part 1 : nuclear fuel

International Nuclear Information System (INIS)

Hilton, B.A.

2000-01-01

The long-term performance of Department of Energy (DOE) spent nuclear fuel (SNF) in a mined geologic disposal system depends highly on fuel oxidation and subsequent radionuclide release. The oxidation rates of nuclear fuels are reviewed in this two-volume report to provide a baseline for comparison with release rate data and technical rationale for predicting general corrosion behavior of DOE SNF. The oxidation rates of nuclear fuels in the DOE SNF inventory were organized according to metallic, Part 1, and non-metallic, Part 2, spent nuclear fuels. This Part 1 of the report reviews the oxidation behavior of three fuel types prototypic of metallic fuel in the DOE SNF inventory: uranium metal, uranium alloys and aluminum-based dispersion fuels. The oxidation rates of these fuels were evaluated in oxygen, water vapor, and water. The water data were limited to pure water corrosion as this represents baseline corrosion kinetics. Since the oxidation processes and kinetics discussed in this report are limited to pure water, they are not directly applicable to corrosion rates of SNF in water chemistry that is significantly different (such as may occur in the repository). Linear kinetics adequately described the oxidation rates of metallic fuels in long-term corrosion. Temperature dependent oxidation rates were determined by linear regression analysis of the literature data. As expected the reaction rates of metallic fuels dramatically increase with temperature. The uranium metal and metal alloys have stronger temperature dependence than the aluminum dispersion fuels. The uranium metal/water reaction exhibited the highest oxidation rate of the metallic fuel types and environments that were reviewed. Consequently, the corrosion properties of all DOE SNF may be conservatively modeled as uranium metal, which is representative of spent N-Reactor fuel. The reaction rate in anoxic, saturated water vapor was essentially the same as the water reaction rate. The long-term intrinsic

Social awareness on nuclear fuel cycle

International Nuclear Information System (INIS)

Tanigaki, Toshihiko

2006-01-01

In the present we surveyed public opinion regarding the nuclear fuel cycle to find out about the social awareness about nuclear fuel cycle and nuclear facilities. The study revealed that people's image of nuclear power is more familiar than the image of the nuclear fuel cycle. People tend to display more recognition and concern towards nuclear power and reprocessing plants than towards other facilities. Comparatively speaking, they tend to perceive radioactive waste disposal facilities and nuclear power plants as being highly more dangerous than reprocessing plants. It is found also that with the exception of nuclear power plants don't know very much whether nuclear fuel cycle facilities are in operation in Japan or not. The results suggests that 1) the relatively mild image of the nuclear fuel cycle is the result of the interactive effect of the highly dangerous image of nuclear power plants and the less dangerous image of reprocessing plants; and 2) that the image of a given plant (nuclear power plant, reprocessing plant, radioactive waste disposal facility) is influenced by the fact of whether the name of the plant suggests the presence of danger or not. (author)

International issue: the nuclear fuel cycle

International Nuclear Information System (INIS)

Anon.

1982-01-01

In this special issue a serie of short articles of informations are presented on the following topics: the EEC's medium term policy regarding the reprocessing and storage of spent fuel, France's natural uranium supply, the Pechiney Group in the nuclear field, zircaloy cladding for nuclear fuel elements, USSI: a major French nuclear engineering firm, gaseous diffusion: the only commercial enrichment process, the transport of nuclear materials in the fuel cycle, Cogema and spent fuel reprocessing, SGN: a leader in the fuel cycle, quality control of mechanical, thermal and termodynamic design in nuclear engineering, Sulzer's new pump testing station in Mantes, the new look of the Ateliers et Chantiers de Bretagne, tubes and piping in nuclear power plants, piping in pressurized water reactor. All these articles are written in English and in French [fr

Overview of the Russian nuclear industry

International Nuclear Information System (INIS)

2008-02-01

In 2004, President Poutine decided to replace the atomic energy ministry (Minatom) by the federal atomic energy agency (Rosatom). Several projects were launched during the next two years which aimed at bringing back Russia to the fore front of the world leaders of nuclear energy use and nuclear technology export. In 2007, Rosatom agency was changed to a public holding company and a new company, named Atomenergoprom, was created which gathers all civil nuclear companies (AtomEnergoMash for the exploitation of power plants, Technabsexport (Tenex) specialized in enrichment or Atomstryexport in charge of export activities). Thus, Rosatom is at the head of all civilian and military nuclear companies, of all research centers, and of all nuclear and radiological safety facilities. In 2006, Russian nuclear power plants supplied 15.8% of the whole power consumption. Russia wishes to develop its nuclear program with the construction of new reactors in order to reach a nuclear electricity share of 25% from now to 2020. This paper presents first the 2007 institutional reform of the Russian atomic sector, and the three sectorial federal programmes: 1 - development of the nuclear energy industrial complex for the 2007-2010 era and up to 2015 (future power plants, nuclear fuel centers and reactor prototypes), 2 - nuclear safety and radioprotection for the 2008-2015 era (waste management, remedial actions, radiation protection), 3 - military program (confidential). Then, the paper presents: the international actions (export of Russian technology, cooperation agreements, non-proliferation), the situation of the existing nuclear park (reactors in operation, stopped, under construction and in project), the fuel cycle activities (production of natural uranium, enrichment, fuel fabrication, spent fuel storage, reprocessing, waste management), the nuclear R and D in Russia, and the nuclear safety authority. (J.S.)

Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum-Resistant Ovarian Cancer

DEFF Research Database (Denmark)

Chen, Ying; Camacho, Sandra Catalina; Silvers, Thomas R

2017-01-01

Purpose: The high fatality-to-case ratio of ovarian cancer is directly related to platinum resistance. Exportin-1 (XPO1) is a nuclear exporter that mediates nuclear export of multiple tumor suppressors. We investigated possible clinicopathologic correlations of XPO1 expression levels and evaluate...

Nuclear export controls and the CTBT: Where we`ve been and challenges ahead -- Views of an engineer

Energy Technology Data Exchange (ETDEWEB)

Lundy, A.S.

1998-09-01

The paper discusses the following topics: the importance of export controls; the uniqueness of nuclear weapons and their export control requirements; ``dual-use`` controls; and recent developments in nonproliferation beyond export control. Also discussed are some non-obvious challenges which include computer modeling and visualization, and fissile material availability and instant nukes. The author concludes by asking the Nuclear Suppliers Group to consider whether there are ways to make its controls more effective.

Nuclear export controls and the CTBT: Where we've been and challenges ahead - Views of an engineer

International Nuclear Information System (INIS)

Lundy, A.S.

1998-01-01

The paper discusses the following topics: the importance of export controls; the uniqueness of nuclear weapons and their export control requirements; ''dual-use'' controls; and recent developments in nonproliferation beyond export control. Also discussed are some non-obvious challenges which include computer modeling and visualization, and fissile material availability and instant nukes. The author concludes by asking the Nuclear Suppliers Group to consider whether there are ways to make its controls more effective

Nuclear fuel cycle

International Nuclear Information System (INIS)

1993-01-01

Status of different nuclear fuel cycle phases in 1992 is discussed including the following issues: uranium exploration, resources, supply and demand, production, market prices, conversion, enrichment; reactor fuel technology; spent fuel management, as well as trends of these phases development up to the year 2010. 10 refs, 11 figs, 15 tabs

Define rules for the exporter and importer of minerals or ores containing nuclear elements

International Nuclear Information System (INIS)

1969-01-01

The present resolution establishes regulations for the exporter of minerals or ores containing associated nuclear elements, and for the importer of chemical compounds of technical purity grade, containing a quantity of fissile of fertile materials equal to the existent in the exported material

Performance of candu-6 fuel bundles manufactured in romania nuclear fuel plant

International Nuclear Information System (INIS)

Bailescu, A.; Barbu, A.; Din, F.; Dinuta, G.; Dumitru, I.; Musetoiu, A.; Serban, G.; Tomescu, A.

2013-01-01

The purpose of this article is to present the performance of nuclear fuel produced by Nuclear Fuel Plant (N.F.P.) - Pitesti during 1995 - 2012 and irradiated in units U1 and U2 from Nuclear Power Plant (N.P.P.) Cernavoda and also present the Nuclear Fuel Plant (N.F.P.) - Pitesti concern for providing technology to prevent the failure causes of fuel bundles in the reactor. This article presents Nuclear Fuel Plant (N.F.P.) - Pitesti experience on tracking performance of nuclear fuel in reactor and strategy investigation of fuel bundles notified as suspicious and / or defectives both as fuel element and fuel bundle, it analyzes the possible defects that can occur at fuel bundle or fuel element and can lead to their failure in the reactor. Implementation of modern technologies has enabled optimization of manufacturing processes and hence better quality stability of achieving components (end caps, chamfered sheath), better verification of end cap - sheath welding. These technologies were qualified by Nuclear Fuel Plant (N.F.P.) - Pitesti on automatic and Computer Numerical Control (C.N.C.) programming machines. A post-irradiation conclusive analysis which will take place later this year (2013) in Institute for Nuclear Research Pitesti (the action was initiated earlier this year by bringing a fuel bundle which has been reported defective by pool visual inspection) will provide additional information concerning potential damage causes of fuel bundles due to manufacturing processes. (authors)

Development of high burnup nuclear fuel technology

International Nuclear Information System (INIS)

Suk, Ho Chun; Kang, Young Hwan; Jung, Jin Gone; Hwang, Won; Park, Zoo Hwan; Ryu, Woo Seog; Kim, Bong Goo; Kim, Il Gone

1987-04-01

The objectives of the project are mainly to develope both design and manufacturing technologies for 600 MWe-CANDU-PHWR-type high burnup nuclear fuel, and secondly to build up the foundation of PWR high burnup nuclear fuel technology on the basis of KAERI technology localized upon the standard 600 MWe-CANDU- PHWR nuclear fuel. So, as in the first stage, the goal of the program in the last one year was set up mainly to establish the concept of the nuclear fuel pellet design and manufacturing. The economic incentives for high burnup nuclear fuel technology development are improvement of fuel utilization, backend costs plant operation, etc. Forming the most important incentives of fuel cycle costs reduction and improvement of power operation, etc., the development of high burnup nuclear fuel technology and also the research on the incore fuel management and safety and technologies are necessary in this country

Study Of Thorium As A Nuclear Fuel.

Directory of Open Access Journals (Sweden)

Prakash Humane

2017-10-01

Full Text Available Conventional fuel sources for power generation are to be replacing by nuclear power sources like nuclear fuel Uranium. But Uranium-235 is the only fissile fuel which is in 0.72 found in nature as an isotope of Uranium-238. U-238 is abundant in nature which is not fissile while U-239 by alpha decay naturally converted to Uranium- 235. For accompanying this nuclear fuel there is another nuclear fuel Thorium is present in nature is abundant can be used as nuclear fuel and is as much as safe and portable like U-235.

Nuclear fuel burn-up economy

International Nuclear Information System (INIS)

Matausek, M.

1984-01-01

In the period 1981-1985, for the needs of Utility Organization, Beograd, and with the support of the Scientific Council of SR Srbija, work has been performed on the study entitled 'Nuclear Fuel Burn-up Economy'. The forst [phase, completed during the year 1983 comprised: comparative analysis of commercial NPP from the standpoint of nuclear fuel requirements; development of methods for fuel burn-up analysis; specification of elements concerning the nuclear fuel for the tender documentation. The present paper gives the short description of the purpose, content and results achieved in the up-to-now work on the study. (author)

Nuclear power and its fuel cycle

International Nuclear Information System (INIS)

Wymer, R.G.

1986-01-01

A series of viewgraphs describes the nuclear fuel cycle and nuclear power, covering reactor types, sources of uranium, enrichment of uranium, fuel fabrication, transportation, fuel reprocessing, and radioactive wastes

Nuclear fuel quality assurance

International Nuclear Information System (INIS)

1976-01-01

Full text: Quality assurance is used extensively in the design, construction and operation of nuclear power plants. This methodology is applied to all activities affecting the quality of a nuclear power plant in order to obtain confidence that an item or a facility will perform satisfactorily in service. Although the achievement of quality is the responsibility of all parties participating in a nuclear power project, establishment and implementation of the quality assurance programme for the whole plant is a main responsibility of the plant owner. For the plant owner, the main concern is to achieve control over the quality of purchased products or services through contractual arrangements with the vendors. In the case of purchase of nuclear fuel, the application of quality assurance might be faced with several difficulties because of the lack of standardization in nuclear fuel and the proprietary information of the fuel manufacturers on fuel design specifications and fuel manufacturing procedures. The problems of quality assurance for purchase of nuclear fuel were discussed in detail during the seminar. Due to the lack of generally acceptable standards, the successful application of the quality assurance concept to the procurement of fuel depends on how much information can be provided by the fuel manufacturer to the utility which is purchasing fuel, and in what form and how early this information can be provided. The extent of information transfer is basically set out in the individual vendor-utility contracts, with some indirect influence from the requirements of regulatory bodies. Any conflict that exists appears to come from utilities which desire more extensive control over the product they are buying. There is a reluctance on the part of vendors to permit close insight of the purchasers into their design and manufacturing procedures, but there nevertheless seems to be an increasing trend towards release of more information to the purchasers. It appears that

Vibratory-compacted (vipac/sphere-pac) nuclear fuels - a comparison with pelletized nuclear fuels

Energy Technology Data Exchange (ETDEWEB)

Chidester, K.; Rubin, J. [Los Alamos National Lab., NM (United States); Thompson, M

2001-07-01

In order to achieve the packing densities required for nuclear fuel stability, economy and performance, the fuel material must be densified. This has traditionally been performed by high-temperature sintering. (At one time, fuel densification was investigated using cold/hot swaging. However, this fabrication method has become uncommon.) Alternatively, fuel can be densified by vibratory compaction (VIPAC). During the late 1950's and into the 1970's, in the U.S., vibratory compaction fuel was fabricated and test irradiated to evaluate its applicability compared to the more traditional pelletized fuel for nuclear reactors. These activities were primarily focused on light water reactors (LWR) but some work was performed for fast reactors. This paper attempts to summarize these evaluations and proposes to reconsider VIPAC fuel for future use. (author)

Vibratory-compacted (vipac/sphere-pac) nuclear fuels - a comparison with pelletized nuclear fuels

International Nuclear Information System (INIS)

Chidester, K.; Rubin, J.; Thompson, M.

2001-01-01

In order to achieve the packing densities required for nuclear fuel stability, economy and performance, the fuel material must be densified. This has traditionally been performed by high-temperature sintering. (At one time, fuel densification was investigated using cold/hot swaging. However, this fabrication method has become uncommon.) Alternatively, fuel can be densified by vibratory compaction (VIPAC). During the late 1950's and into the 1970's, in the U.S., vibratory compaction fuel was fabricated and test irradiated to evaluate its applicability compared to the more traditional pelletized fuel for nuclear reactors. These activities were primarily focused on light water reactors (LWR) but some work was performed for fast reactors. This paper attempts to summarize these evaluations and proposes to reconsider VIPAC fuel for future use. (author)

Simplification of the Provisions of the Nuclear Energy Act on Imports and Exports; A Working Group Report

International Nuclear Information System (INIS)

2001-01-01

The Ministry of Trade and Industry appointed a working group to map out possibilities of simplifying the provisions on imports and exports of nuclear products and to submit a proposal for the amendment of the Nuclear Energy Act in this respect. The working group should especially map out relevant international and EU norms and consider to what extent it would be possible to replace the present licensing procedure with obligations imposed on operators and/or a notification procedure. The working group should further study the possibility of combining the provisions on the control of nuclear materials, the safety of transports of nuclear and other radioactive material nuclear liability and physical protection of nuclear materials with the provisions on imports and exports. The working group did not discuss the provisions on the imports and exports of nuclear waste. The Council Regulation concerning the control of exports of dual-use items and technology, which entered into force in September 2000, and the amendment of the Regulation with a view to nuclear material adopted in January 2001 call for an amendment of the provisions of the Nuclear Energy Act concerning exports. The working group proposes that a direct reference to the EU Regulation should be included in the Nuclear Energy Decree. The definition of exports is proposed to be changed so that it corresponds to the definition in the EU Regulation. The Nuclear Energy Decree should, however, comprise provisions on applying for an authorization, on a licensing authority and on the possibility of applying for a global authorisation. The global authorisation shall replace the Intra-Community trade licence, which is proposed to be abolished. It is proposed that the Ministry of Trade and Industry should be the licensing authority. It is further proposed that provisions should be issued on a notification procedure for products falling under the scope of the Nuclear Energy Act for which no export authorisation is

Prospects of nuclear power in fossil fuel saving

International Nuclear Information System (INIS)

Chernavskij, S.Ya.

1984-01-01

Economic aspects of the World energy situation are considered. The growth in the world prices for energy and energy resources has demanded to reconstruct the structure of both consumers and primary energy resources. The nuclear power development is one of the most important aspects of this reconstruction. In connection with its development the acceptability of nuclear power technology and possible spheres of its application in different fields of power engineering are considered. When discussing these problems one pays the main attention to the psychological effect and potential measures for its compensation. A forecast estimate is given of specific capital investments in and expenditures on electric energy production for NPPs and conventional power stations for the considered period of 30 years. The estimates are differentiated for the European and Asian parts of the country. The problems of developing nuclear central heating-and-power plants and nuclear thermal stations are discussed. It is pointed out that presently no sufficient experience has been gained in their commerical operation to discuss for sure the prospects of their wide-scale utilization. Results of calculations are presented showing that in the range of high-temperature processes the use of electric energy based on the nuclear power development is more efficient than direct combustion of fossil fuel as estimated with respect to its export at the world market prices

Nuclear fuel element

International Nuclear Information System (INIS)

Knowles, A.N.

1979-01-01

A nuclear fuel-containing body for a high temperature gas cooled nuclear reactor is described which comprises a flat plate in which the nuclear fuel is contained as a dispersion of fission product-retaining coated fuel particles in a flat sheet of graphitic or carbonaceous matrix material. The flat sheet is clad with a relatively thin layer of unfuelled graphite bonded to the sheet by being formed initially from a number of separate preformed graphitic artefacts and then platen-pressed on to the exterior surfaces of the flat sheet, both the matrix material and the artefacts being in a green state, to enclose the sheet. A number of such flat plates are supported edge-on to the coolant flow in the bore of a tube made of neutron moderating material. Where a number of tiers of plates are superimposed on one another, the abutting edges are chamfered to reduce vibration. (author)

The evolving nuclear fuel cycle

International Nuclear Information System (INIS)

Gale, J.D.; Hanson, G.E.; Coleman, T.A.

1993-01-01

Various economics and political pressures have shaped the evolution of nuclear fuel cycles over the past 10 to 15 yr. Future trends will no doubt be similarly driven. This paper discusses the influences that long cycles, high discharge burnups, fuel reliability, and costs will have on the future nuclear cycle. Maintaining the economic viability of nuclear generation is a key issue facing many utilities. Nuclear fuel has been a tremendous bargain for utilities, helping to offset major increases in operation and maintenance (O ampersand M) expenses. An important factor in reducing O ampersand M costs is increasing capacity factor by eliminating outages

Nuclear fuel cycle modelling using MESSAGE

International Nuclear Information System (INIS)

Guiying Zhang; Dongsheng Niu; Guoliang Xu; Hui Zhang; Jue Li; Lei Cao; Zeqin Guo; Zhichao Wang; Yutong Qiu; Yanming Shi; Gaoliang Li

2017-01-01

In order to demonstrate the possibilities of application of MESSAGE tool for the modelling of a Nuclear Energy System at the national level, one of the possible open nuclear fuel cycle options based on thermal reactors has been modelled using MESSAGE. The steps of the front-end and back-end of nuclear fuel cycle and nuclear reactor operation are described. The optimal structure for Nuclear Power Development and optimal schedule for introducing various reactor technologies and fuel cycle options; infrastructure facilities, nuclear material flows and waste, investments and other costs are demonstrated. (author)

International Summer School on Nuclear Fuel

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-07-01

In cooperation with the OECD Nuclear Energy Agency (NEA), the Halden Reactor Project organised a Summer School on nuclear fuel in the period August 28 September 1, 2000. The summer school was primarily intended for people who wanted to become acquainted with fuel-related subjects and issues without being experts. It was especially hoped that the summer school would serve to transfer knowledge to the ''young generation'' in the field of nuclear fuel. Experts from Halden Project member organisations gave the following presentations: (1) Overview of the nuclear community, (2) Criteria for safe operation and design of nuclear fuel, (3) Fuel design and fabrication, (4) Cladding Manufacturing, (5) Overview of the Halden Reactor Project, (6) Fuel performance evaluation and modelling, (7) Fission gas release, and (8) Cladding issues. Except for the Overview, which is a written paper, the other contributions are overhead figures from spoken lectures.

Nuclear Fusion Fuel Cycle Research Perspectives

International Nuclear Information System (INIS)

Chung, Hongsuk; Koo, Daeseo; Park, Jongcheol; Kim, Yeanjin; Yun, Sei-Hun

2015-01-01

As a part of the International Thermonuclear Experimental Reactor (ITER) Project, we at the Korea Atomic Energy Research Institute (KAERI) and our National Fusion Research Institute (NFRI) colleagues are investigating nuclear fusion fuel cycle hardware including a nuclear fusion fuel Storage and Delivery System (SDS). To have a better knowledge of the nuclear fusion fuel cycle, we present our research efforts not only on SDS but also on the Fuel Supply System (FS), Tokamak Exhaust Processing System (TEP), Isotope Separation System (ISS), and Detritiation System (DS). To have better knowledge of the nuclear fusion fuel cycle, we presented our research efforts not only on SDS but also on the Fuel Supply System (FS), Tokamak Exhaust Processing System (TEP), Isotope Separation System (ISS), and Detritiation System (DS). Our efforts to enhance the tritium confinement will be continued for the development of cleaner nuclear fusion power plants

Material input of nuclear fuel

International Nuclear Information System (INIS)

Rissanen, S.; Tarjanne, R.

2001-01-01

The Material Input (MI) of nuclear fuel, expressed in terms of the total amount of natural material needed for manufacturing a product, is examined. The suitability of the MI method for assessing the environmental impacts of fuels is also discussed. Material input is expressed as a Material Input Coefficient (MIC), equalling to the total mass of natural material divided by the mass of the completed product. The material input coefficient is, however, only an intermediate result, which should not be used as such for the comparison of different fuels, because the energy contents of nuclear fuel is about 100 000-fold compared to the energy contents of fossil fuels. As a final result, the material input is expressed in proportion to the amount of generated electricity, which is called MIPS (Material Input Per Service unit). Material input is a simplified and commensurable indicator for the use of natural material, but because it does not take into account the harmfulness of materials or the way how the residual material is processed, it does not alone express the amount of environmental impacts. The examination of the mere amount does not differentiate between for example coal, natural gas or waste rock containing usually just sand. Natural gas is, however, substantially more harmful for the ecosystem than sand. Therefore, other methods should also be used to consider the environmental load of a product. The material input coefficient of nuclear fuel is calculated using data from different types of mines. The calculations are made among other things by using the data of an open pit mine (Key Lake, Canada), an underground mine (McArthur River, Canada) and a by-product mine (Olympic Dam, Australia). Furthermore, the coefficient is calculated for nuclear fuel corresponding to the nuclear fuel supply of Teollisuuden Voima (TVO) company in 2001. Because there is some uncertainty in the initial data, the inaccuracy of the final results can be even 20-50 per cent. The value

The Nuclear Fuel Cycle Information System

International Nuclear Information System (INIS)

1987-02-01

The Nuclear Fuel Cycle Information System (NFCIS) is an international directory of civilian nuclear fuel cycle facilities. Its purpose is to identify existing and planned nuclear fuel cycle facilities throughout the world and to indicate their main parameters. It includes information on facilities for uranium ore processing, refining, conversion and enrichment, for fuel fabrication, away-from-reactor storage of spent fuel and reprocessing, and for the production of zirconium metal and Zircaloy tubing. NFCIS currently covers 271 facilities in 32 countries and includes 171 references

World nuclear fuel cycle requirements 1989

International Nuclear Information System (INIS)

1989-01-01

This analysis report presents the projected requirements for uranium concentrate and uranium enrichment services to fuel the nuclear power plants expected to be operating under two nuclear supply scenarios. These two scenarios, the Lower Reference and Upper Reference cases, apply to the United States, Canada, Europe, the Far East, and other countries in the World Outside Centrally Planned Economic Areas (WOCA). A No New Orders scenarios is also presented for the Unites States. This report contains an analysis of the sensitivities of the nuclear fuel cycle projections to different levels and types of projected nuclear capacity, different enrichment tails assays, higher and lower capacity factors, changes in nuclear fuel burnup levels, and other exogenous assumptions. The projections for the United States generally extend through the year 2020, and the WOCA projections, which include the United States, are provided through 2010. The report also presents annual projections of spent nuclear fuel; discharges and inventories of spent fuel. Appendix D includes domestic spent fuel projections through the year 2020 for the Lower and Upper Reference cases and through 2036, the last year in which spent fuel is discharged, for the No New Orders case

Commercialization of nuclear fuel cycle business

International Nuclear Information System (INIS)

Yakabe, Hideo

1998-01-01

Japan depends on foreign countries almost for establishing nuclear fuel cycle. Accordingly, uranium enrichment, spent fuel reprocessing and the safe treatment and disposal of radioactive waste in Japan is important for securing energy. By these means, the stable supply of enriched uranium, the rise of utilization efficiency of uranium and making nuclear power into home-produced energy can be realized. Also this contributes to the protection of earth resources and the preservation of environment. Japan Nuclear Fuel Co., Ltd. operates four business commercially in Rokkasho, Aomori Prefecture, aiming at the completion of nuclear fuel cycle by the technologies developed by Power Reactor and Nuclear Fuel Development Corporation and the introduction of technologies from foreign countries. The conditions of location of nuclear fuel cycle facilities and the course of the location in Rokkasho are described. In the site of about 740 hectares area, uranium enrichment, burying of low level radioactive waste, fuel reprocessing and high level waste control have been carried out, and three businesses except reprocessing already began the operation. The state of operation of these businesses is reported. Hereafter, efforts will be exerted to the securing of safety through trouble-free operation and cost reduction. (K.I.)

Spent Nuclear Fuel project, project management plan

International Nuclear Information System (INIS)

Fuquay, B.J.

1995-01-01

The Hanford Spent Nuclear Fuel Project has been established to safely store spent nuclear fuel at the Hanford Site. This Project Management Plan sets forth the management basis for the Spent Nuclear Fuel Project. The plan applies to all fabrication and construction projects, operation of the Spent Nuclear Fuel Project facilities, and necessary engineering and management functions within the scope of the project

The impact of the multilateral approach to the nuclear fuel cycle in Malaysia's nuclear fuel cycle policy

International Nuclear Information System (INIS)

Baharuddin, B.; Ferdinand, P.

2014-01-01

Since the Pakistan-India nuclear weapon race, the North Korean nuclear test and the September 11 attack revealed Abdul Qadeer Khan's clandestine nuclear black market and the fear that Iran's nuclear program may be used for nuclear weapon development, scrutiny of activities related to nuclear technologies, especially technology transfer has become more stringent. The nuclear supplier group has initiated a multilateral nuclear fuel cycle regime with the purpose of guaranteeing nuclear fuel supply and at the same time preventing the spread of nuclear proliferation. Malaysia wants to develop a programme for the peaceful use of nuclear energy and it needs to accommodate itself to this policy. When considering developing a nuclear fuel cycle policy, the key elements that Malaysia needs to consider are the extent of the fuel cycle technologies that it intends to acquire and the costs (financial and political) of acquiring them. Therefore, this paper will examine how the multilateral approach to the nuclear fuel cycle may influence Malaysia's nuclear fuel cycle policy, without jeopardising the country's rights and sovereignty as stipulated under the NPT. (authors)

Nuclear energy industry in Russia promoting global strategy

International Nuclear Information System (INIS)

Kobayashi, Masaharu

2001-01-01

Since former USSR disintegrated to birth new Russia on December, 1991, it already passed ten years. As Russian economic hardship affected its nuclear energy development, No.1 reactor of the Rostov nuclear power station (VVER-1000) established its full power operation on September, 2001 after passing eight years of pausing period as a Russian nuclear power station, at dull development of nuclear energy in the world. When beginning of its commercial operation, scale of nuclear power generation under operation in Russia will reach to the fourth one in the world by getting over the one in Germany. Russia also begins international business on reprocessing of spent fuel and intermittent storage. And, Russia positively develops export business of concentrated uranium and nuclear fuel, too. Furthermore, Russia shows some positive initiatives on export of nuclear power station to China, Iran and India, and development on advanced nuclear reactor and nuclear fuel cycle forecast to future. Here was introduced on international developmental development of nuclear energy industry activated recently at delayed time for this ten years. (G.K.)

Alternatives for nuclear fuel disposal

International Nuclear Information System (INIS)

Ramirez S, J. R.; Badillo A, V.; Palacios H, J.; Celis del Angel, L.

2010-10-01

The spent fuel is one of the most important issues in the nuclear industry, currently spent fuel management is been cause of great amount of research, investments in the construction of repositories or constructing the necessary facilities to reprocess the fuel, and later to recycle the plutonium recovered in thermal reactors. What is the best solution? or, What is the best technology for a specific solution? Many countries have deferred the decision on selecting an option, while other works actively constructing repositories and others implementing the reprocessing facilities to recycle the plutonium obtained from nuclear spent fuel. In Mexico the nuclear power is limited to two reactors BWR type and medium size. So the nuclear spent fuel discharged has been accommodated at reactor's spent fuel pools. Originally these pools have enough capacity to accommodate spent fuel for the 40 years of designed plant operation. However, currently is under process an extended power up rate to 20% of their original power and also there are plans to extend operational life for 20 more years. Under these conditions there will not be enough room for spent fuel in the pools. So this work describes some different alternatives that have been studied in Mexico to define which will be the best alternative to follow. (Author)

On the role of fusion neutron source with thorium blanket in forming the nuclide composition of the nuclear fuel cycle of the Russian Federation

Energy Technology Data Exchange (ETDEWEB)

Shmelev, A. N.; Kulikov, G. G., E-mail: ggkulikov@mephi.ru [National Research Nuclear University (Moscow Engineering Physics Institute) (Russian Federation)

2016-12-15

The possible role of available thorium resources of the Russian Federation in utilization of thorium in the closed (U–Pu)-fuel cycle of nuclear power is considered. The efficiency of application of fusion neutron sources with thorium blanket for economical use of available thorium resources is demonstrated. The objective of this study is the search for a solution of such major tasks of nuclear power as reduction of the amount of front-end operations in the nuclear fuel cycle and enhancement of its protection against uncontrolled proliferation of fissile materials with the smallest possible alterations in the fuel cycle. The earlier results are analyzed, new information on the amount of thorium resources of the Russian Federation is used, and additional estimates are made. The following basic results obtained on the basis of the assumption of involving fusion reactors with Th-blanket in future nuclear power for generation of the light uranium fraction {sup 232+233+234}U and {sup 231}Pa are formulated. (1) The fuel cycle would shift from fissile {sup 235}U to {sup 233}U, which is more attractive for thermal power reactors. (2) The light uranium fraction is the most “protected” in the uranium fuel component, and being mixed with regenerated uranium, it would become reduced-enrichment uranium fuel, which would relieve the problem of nonproliferation of the fissile material. (3) The addition of {sup 231}Pa into the fuel would stabilize its neutron-multiplying properties, thus making it possible to implement a long fuel residence time and, as a consequence, increase the export potential of the whole nuclear power technology. (4) The available thorium resource in the vicinity of Krasnoufimsk is sufficient for operation of the large-scale nuclear power industry of the Russian Federation with an electric power of 70 GW for more than one quarter of a century. The general conclusion is that involvement of a small number of fusion reactors with Th-blanket in the future

Nuclear power: a British view

International Nuclear Information System (INIS)

Shaw, G.

1985-01-01

The subject is covered in sections, entitled: importance of nuclear power; the problems; fuel availability (uranium purchasing policy; uranium market; longer-term demand; enrichment market; fast reactor); non-proliferation and nuclear export policy; public acceptability. (U.K.)

Perspective of nuclear fuel cycle for sustainable nuclear energy

International Nuclear Information System (INIS)

Fukuda, K.; Bonne, A.; Kagramanian, V.

2001-01-01

Nuclear power, on a life-cycle basis, emits about the same level of carbon per unit of electricity generated as wind and solar power. Long-term energy demand and supply analysis projects that global nuclear capacities will expand substantially, i.e. from 350 GW today to more than 1,500 GW by 2050. Uranium supply, spent fuel and waste management, and a non-proliferation nuclear fuel cycle are essential factors for sustainable nuclear power growth. An analysis of the uranium supply up to 2050 indicates that there is no real shortage of potential uranium available if based on the IIASA/WEC scenario on medium nuclear energy growth, although its market price may become more volatile. With regard to spent fuel and waste management, the short term prediction foresees that the amount of spent fuel will increase from the present 145,000 tHM to more than 260,000 tHM in 2015. The IPCC scenarios predicted that the spent fuel quantities accumulated by 2050 will vary between 525 000 tHM and 3 210 000 tHM. Even according to the lowest scenario, it is estimated that spent fuel quantity in 2050 will be double the amount accumulated by 2015. Thus, waste minimization in the nuclear fuel cycle is a central tenet of sustainability. The proliferation risk focusing on separated plutonium and resistant technologies is reviewed. Finally, the IAEA Project INPRO is briefly introduced. (author)

Spent nuclear fuel in Bulgaria

International Nuclear Information System (INIS)

Peev, P.; Kalimanov, N.

1999-01-01

The development of the nuclear energy sector in Bulgaria is characterized by two major stages. The first stage consisted of providing a scientific basis for the programme for development of the nuclear energy sector in the country and was completed with the construction of an experimental water-water reactor. At present, spent nuclear fuel from this reactor is placed in a water filled storage facility and will be transported back to Russia. The second stage consisted of the construction of the 6 NPP units at the Kozloduy site. The spent nuclear fuel from the six units is stored in at reactor pools and in an additional on-site storage facility which is nearly full. In order to engage the government of the country with the on-site storage problems, the new management of the National Electric Company elaborated a policy on nuclear fuel cycle and radioactive waste management. The underlying policy is de facto the selection of the 'deferred decision' option for its spent fuel management. (author)

Improved nuclear fuel element

International Nuclear Information System (INIS)

1974-01-01

A nuclear fuel element for use in the core of a nuclear reactor is disclosed and has a metal liner disposed between the cladding and the nuclear fuel material and a high lubricity material in the form of a coating disposed between the liner and the cladding. The liner preferably has a thickness greater than the longest fission product recoil distance and is composed of a low neutron capture cross-section material. The liner is preferably composed of zirconium, an alloy of zirconium, niobium or an alloy of niobium. The liner serves as a preferential reaction site for volatile impurities and fission products and protects the cladding from contact and reaction with such impurities and fission products. The high lubricity material acts as an interface between the liner and the cladding and reduces localized stresses on the cladding due to fuel expansion and cracking of the fuel

Nuclear fuel storage facility

International Nuclear Information System (INIS)

Matsumoto, Takashi; Isaka, Shinji.

1987-01-01

Purpose: To increase the spent fuel storage capacity and reduce the installation cost in a nuclear fuel storage facility. Constitution: Fuels handled in the nuclear fuel storage device of the present invention include the following four types: (1) fresh fuels, (2) 100 % reactor core charged fuels, (3) spent fuels just after taking out and (4) fuels after a certain period (for example one half-year) from taking out of the reactor. Reactivity is high for the fuels (1), and some of fuels (2), while low in the fuels (3) (4), Source intensity is strong for the fuels (3) and some of the fuels (2), while it is low for the fuels (1) and (4). Taking notice of the fact that the reactivity, radioactive source intensity and generated after heat are different in the respective fuels, the size of the pool and the storage capacity are increased by the divided storage control. While on the other hand, since the division is made in one identical pool, the control method becomes important, and the working range is restricted by means of a template, interlock, etc., the operation mode of the handling machine is divided into four, etc. for preventing errors. (Kamimura, M.)

World nuclear fuel cycle requirements 1990

International Nuclear Information System (INIS)

1990-01-01

This analysis report presents the projected requirements for uranium concentrate and uranium enrichment services to fuel the nuclear power plants expected to be operating under three nuclear supply scenarios. Two of these scenarios, the Lower Reference and Upper Reference cases, apply to the United States, Canada, Europe, the Far East, and other countries with free market economies (FME countries). A No New Orders scenario is presented only for the United States. These nuclear supply scenarios are described in Commercial Nuclear Power 1990: Prospects for the United States and the World (DOE/EIA-0438(90)). This report contains an analysis of the sensitivities of the nuclear fuel cycle projections to different levels and types of projected nuclear capacity, different enrichment tails assays, higher and lower capacity factors, changes in nuclear fuel burnup levels, and other exogenous assumptions. The projections for the United States generally extend through the year 2020, and the FME projections, which include the United States, are provided through 2010. The report also presents annual projections of spent nuclear fuel discharges and inventories of spent fuel. Appendix D includes domestic spent fuel projections through the year 2030 for the Lower and Upper Reference cases and through 2040, the last year in which spent fuel is discharged, for the No New Orders case. These disaggregated projections are provided at the request of the Department of Energy's Office of Civilian Radioactive Waste Management

Proceeding of the Fifth Scientific Presentation on Nuclear Fuel Cycle: Development of Nuclear Fuel Cycle Technology in Third Millennium

International Nuclear Information System (INIS)

Suripto, A.; Sastratenaya, A.S.; Sutarno, D.

2000-01-01

The proceeding contains papers presented in the Fifth Scientific Presentation on Nuclear Fuel Element Cycle with theme of Development of Nuclear Fuel Cycle Technology in Third Millennium, held on 22 February in Jakarta, Indonesia. These papers were divided by three groups that are technology of exploration, processing, purification and analysis of nuclear materials; technology of nuclear fuel elements and structures; and technology of waste management, safety and management of nuclear fuel cycle. There are 35 papers indexed individually. (id)

Romanian nuclear fuel program: past, present and future

International Nuclear Information System (INIS)

Budan, O.; Rotaru, I.; Galeriu, C.A.

1997-01-01

The paper presents and comments the policy adopted in Romania for the production of CANDU-6 nuclear fuel before and after 1990. In this paper the word 'past' refers to the period before 1990 and 'present' to the 1990-1997 period. The CANDU-6 nuclear fuel manufacturing started in Romania in December 1983. Neither AECL nor any Canadian nuclear fuel manufacturer were involved in the Romanian industrial nuclear fuel production before 1990. After January 1990, the new created Romanian Electricity Authority (RENEL) assumed the responsibility for the Romanian Nuclear Power Program. It was RENEL's decision to stop, in June 1990, the nuclear fuel production at the Institute for Nuclear Power Reactors (IRNE) Pitesti. This decision was justified by the Canadian specialists team findings, revealed during a general, but well enough technically founded analysis performed at IRNE in the spring of 1990. All fuel manufactured before June 1990 was quarantined as it was considered of suspect quality. By that time more than 31,000 fuel bundles had already been manufactured. This fuel was stored for subsequent assessment. The paper explains the reasons which provoked this decision. The paper also presents the strategy adopted by RENEL after 1990 regarding the Romanian Nuclear Fuel Program. After a complex program done by Romanian and Canadian partners, in November 1994, AECL issued a temporary certification for the Romanian nuclear fuel plant. During the demonstration manufacturing run, as an essential milestone for the qualification of the Romanian fuel supplier for CANDU-6 reactors, 202 fuel bundles were produced. Of these fuel bundles, 66 were part of the Cernavoda NGS Unit 1 first fuel load (the balance was supplied by Zircatec Precision Industries Inc. - ZPI). The industrial nuclear fuel fabrication re-started in Romania in January 1995 under AECL's periodical monitoring. In December 1995, AECL issued a permanent certificate, stating the Romanian nuclear fuel plant as a qualified

Phosphorylation of zona occludens-2 by protein kinase C epsilon regulates its nuclear exportation.

Science.gov (United States)

Chamorro, David; Alarcón, Lourdes; Ponce, Arturo; Tapia, Rocio; González-Aguilar, Héctor; Robles-Flores, Martha; Mejía-Castillo, Teresa; Segovia, José; Bandala, Yamir; Juaristi, Eusebio; González-Mariscal, Lorenza

2009-09-01

Here, we have analyzed the subcellular destiny of newly synthesized tight junction protein zona occludens (ZO)-2. After transfection in sparse cells, 74% of cells exhibit ZO-2 at the nucleus, and after 18 h the value decreases to 17%. The mutation S369A located within the nuclear exportation signal 1 of ZO-2 impairs the nuclear export of the protein. Because Ser369 represents a putative protein kinase C (PKC) phosphorylation site, we tested the effect of PKC inhibition and stimulation on the nuclear export of ZO-2. Our results strongly suggest that the departure of ZO-2 from the nucleus is regulated by phosphorylation at Ser369 by novel PKCepsilon. To test the route taken by ZO-2 from synthesis to the plasma membrane, we devised a novel nuclear microinjection assay in which the nucleus served as a reservoir for anti-ZO-2 antibody. Through this assay, we demonstrate that a significant amount of newly synthesized ZO-2 goes into the nucleus and is later relocated to the plasma membrane. These results constitute novel information for understanding the mechanisms that regulate the intracellular fate of ZO-2.

International guidelines for fire protection at nuclear installations including nuclear fuel plants, nuclear fuel stores, teaching reactors, research establishments

International Nuclear Information System (INIS)

The guidelines are recommended to designers, constructors, operators and insurers of nuclear fuel plants and other facilities using significant quantities of radioactive materials including research and teaching reactor installations where the reactors generally operate at less than approximately 10 MW(th). Recommendations for elementary precautions against fire risk at nuclear installations are followed by appendices on more specific topics. These cover: fire protection management and organization; precautions against loss during construction alterations and maintenance; basic fire protection for nuclear fuel plants; storage and nuclear fuel; and basic fire protection for research and training establishments. There are numerous illustrations of facilities referred to in the text. (U.K.)

Export Control Guide: Loose Parts Monitoring Systems for Nuclear Power Plants

Energy Technology Data Exchange (ETDEWEB)

Langenberg, Donald W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2012-12-01

This report describes a typical LPMS, emphasizing its application to the RCS of a modern NPP. The report also examines the versatility of AE monitoring technology by describing several nuclear applications other than loose parts monitoring, as well as some non-nuclear applications. In addition, LPMS implementation requirements are outlined, and LPMS suppliers are identified. Finally, U.S. export controls applicable to LPMSs are discussed.

Nuclear exports. Parliamentary control and confidentiality; Parlamentarische Kontrolle und Geheimhaltungsbeduerftigkeit bei Nuklearexporten. Zum Urteil des Bundesverfassungsgerichts vom 21. Oktober 2014

Energy Technology Data Exchange (ETDEWEB)

Feldmann, Ulrike

2015-03-15

With its decision taken on 21. October 2014 (Az.: 2 BvE 5/11) the Federal Constitutional Court (BVerfG) decided during court proceedings between administrative bodies on the scope and limits of the parliamentary right of information. Even though the proceeding did not deal with nuclear exports but arm exports, foreign trade law, however, does not only designate an export licence obligation for military weapons but also for so called dual-use goods meaning goods, which can be used both for friendly as well as for military purposes. The export of these goods requires according to the so-called Dual-Use Regulation (EG) 428/2009 a licence. Annex I category 0 of the regulation (EG) 428/2009 lists a variety of nuclear materials, plants and equipment items for which this licence applies. In the same manner as arm exports, also exports of nuclear dual-use goods are being discussed in a special cabinet committee, the Federal Security Council (BSR), which shall coordinate cross-departmentally the German security and defence policy under consideration of economic interests and which categorises its results, according to the rules of procedure, as confidential. Also legally not regulated but common ''preliminary enquiries'' at the responsible Federal Ministry or rather Federal Office of Economics and Export Control by companies which plan an export and want to affirm the general approval for their export business prior to conclusion of contract take not only place for arm exports but also for nuclear dual-use goods. The decision by the Federal Constitutional Court can be applied to consultations about the authorisation of nuclear dual-use goods.

The new US nuclear non-proliferation and export policy

International Nuclear Information System (INIS)

Welck, S. von.

1981-01-01

The future American nuclear non-proliferation and export policy will be determined chiefly by three elements: (1) Adherence to the former objective of nuclear non-proliferation. (2) A large and varied assortment of old and new tools for implementing this goal. (3) Much more differentiation in applying these tools in the light of the reliability, with respect to non-proliferation policy, of the respective partner. Consequently, it would make little sense for the new Administration to force upon allied industrialized countries, whose nuclear technologies are at the same level as that of the United States, restrictive rules on reprocessing and breeder technology. The new measures designed to curb proliferation are especially meant to destroy motivations that could cause states to own nuclear explosives. This also applies to the removal of economic motivations. (orig.) [de

Nuclear fuel element leak detection system

International Nuclear Information System (INIS)

John, C.D. Jr.

1978-01-01

Disclosed is a leak detection system integral with a wall of a building used to fabricate nuclear fuel elements for detecting radiation leakage from the nuclear fuel elements as the fuel elements exit the building. The leak detecting system comprises a shielded compartment constructed to withstand environmental hazards extending into a similarly constructed building and having sealed doors on both ends along with leak detecting apparatus connected to the compartment. The leak detecting system provides a system for removing a nuclear fuel element from its fabrication building while testing for radiation leaks in the fuel element

Spent nuclear fuel storage - Basic concept

International Nuclear Information System (INIS)

Krempel, Ascanio; Santos, Cicero D. Pacifici dos; Sato, Heitor Hitoshi; Magalhaes, Leonardo de

2009-01-01

According to the procedures adopted in others countries in the world, the spent nuclear fuel elements burned to produce electrical energy in the Brazilian Nuclear Power Plant of Angra do Reis, Central Nuclear Almirante Alvaro Alberto - CNAAA will be stored for a long time. Such procedure will allow the next generation to decide how they will handle those materials. In the future, the reprocessing of the nuclear fuel assemblies could be a good solution in order to have additional energy resource and also to decrease the volume of discarded materials. This decision will be done in the future according to the new studies and investigations that are being studied around the world. The present proposal to handle the nuclear spent fuel is to storage it for a long period of time, under institutional control. Therefore, the aim of this paper is to introduce a proposal of a basic concept of spent fuel storage, which involves the construction of a new storage building at site, in order to increase the present storage capacity of spent fuel assemblies in CNAAA installation; the concept of the spent fuel transportation casks that will transfer the spent fuel assemblies from the power plants to the Spent Fuel Complementary Storage Building and later on from this building to the Long Term Intermediate Storage of Spent Fuel; the concept of the spent fuel canister and finally the basic concept of the spent fuel long term storage. (author)

Chemical characterization of nuclear fuel materials

International Nuclear Information System (INIS)

Ramakumar, K.L.

2011-01-01

India is fabricating nuclear fuels for various types of reactors, for example, (U-Pu) MOX fuel of varying Pu content for boiling water reactors (BWRs), pressurized heavy water reactors (PHWRs), prototype fast breeder reactors (PFBRs), (U-Pu) carbide fuel fast breeder test reactor (FBTR), and U-based fuels for research reactors. Nuclear fuel being the heart of the reactor, its chemical and physical characterisation is an important component of this design. Both the fuel materials and finished fuel products are to be characterised for this purpose. Quality control (both chemical and physical) provides a means to ensure that the quality of the fabricated fuel conforms to the specifications for the fuel laid down by the fuel designer. Chemical specifications are worked out for the major and minor constituents which affect the fuel properties and hence its performance under conditions prevailing in an operating reactor. Each fuel batch has to be subjected to comprehensive chemical quality control for trace constituents, stoichiometry and isotopic composition. A number of advanced process and quality control steps are required to ensure the quality of the fuels. Further more, in the case of Pu-based fuels, it is necessary to extract maximum quality data by employing different evaluation techniques which would result in minimum scrap/waste generation of valuable plutonium. The task of quality control during fabrication of nuclear fuels of various types is both challenging and difficult. The underlying philosophy is total quality control of the fuel by proper mix of process and quality control steps at various stages of fuel manufacture starting from the feed materials. It is also desirable to adapt more than one analytical technique to increase the confidence and reliability of the quality data generated. This is all the most required when certified reference materials are not available. In addition, the adaptation of non-destructive techniques in the chemical quality

Nuclear fuel preheating system

International Nuclear Information System (INIS)

Andrea, C.

1975-01-01

A nuclear reactor new fuel handling system which conveys new fuel from a fuel preparation room into the reactor containment boundary is described. The handling system is provided with a fuel preheating station which is adaptd to heat the new fuel to reactor refueling temperatures in such a way that the fuel is heated from the top down so that fuel element cladding failure due to thermal expansions is avoided. (U.S.)

The tight junction protein Z O-2 has several functional nuclear export signals

International Nuclear Information System (INIS)

Gonzalez-Mariscal, Lorenza; Ponce, Arturo; Alarcon, Lourdes; Jaramillo, Blanca Estela

2006-01-01

The tight junction (TJ) protein ZO-2 changes its subcellular distribution according to the state of confluency of the culture. Thus in confluent monolayers, it localizes at the TJ region whereas in sparse cultures it concentrates at the nucleus. The canine sequence of ZO-2 displays four putative nuclear export signals (NES), two at the second PDZ domain (NES-0 and NES-1) and the rest at the GK region (NES-2 and NES-3). The functionality of NES-0 and NES-3 was unknown, hence here we have explored it with a nuclear export assay, injecting into the nucleus of MDCK cells peptides corresponding to the ZO-2 NES sequences chemically coupled to ovalbumin. We show that both NES-0 and NES-3 are functional and sensitive to leptomycin B. We also demonstrate that NES-1, previously characterized as a non functional NES, is rendered capable of nuclear export upon the acquisition of a negative charge at its Ser369 residue. Experiments performed injecting at the nucleus WT and mutated ZO-2-GST fusion proteins revealed the need of both NES-0 and NES-1, and NES-2 and NES-3 for attaining an efficient nuclear exit of the respective amino and middle segments of ZO-2. Moreover, the transfection of MDCK cells with full-length ZO-2 revealed that the mutation of any of the NES present in the molecule was sufficient to induce nuclear accumulation of the protein

AN ANALYTICAL FRAMEWORK FOR ASSESSING RELIABLE NUCLEAR FUEL SERVICE APPROACHES: ECONOMIC AND NON-PROLIFERATION MERITS OF NUCLEAR FUEL LEASING

International Nuclear Information System (INIS)

Kreyling, Sean J.; Brothers, Alan J.; Short, Steven M.; Phillips, Jon R.; Weimar, Mark R.

2010-01-01

The goal of international nuclear policy since the dawn of nuclear power has been the peaceful expansion of nuclear energy while controlling the spread of enrichment and reprocessing technology. Numerous initiatives undertaken in the intervening decades to develop international agreements on providing nuclear fuel supply assurances, or reliable nuclear fuel services (RNFS) attempted to control the spread of sensitive nuclear materials and technology. In order to inform the international debate and the development of government policy, PNNL has been developing an analytical framework to holistically evaluate the economics and non-proliferation merits of alternative approaches to managing the nuclear fuel cycle (i.e., cradle-to-grave). This paper provides an overview of the analytical framework and discusses preliminary results of an economic assessment of one RNFS approach: full-service nuclear fuel leasing. The specific focus of this paper is the metrics under development to systematically evaluate the non-proliferation merits of fuel-cycle management alternatives. Also discussed is the utility of an integrated assessment of the economics and non-proliferation merits of nuclear fuel leasing.

Nuclear fuel element

International Nuclear Information System (INIS)

Hirama, H.

1978-01-01

A nuclear fuel element comprises an elongated tube having upper and lower end plugs fixed to both ends thereof and nuclear fuel pellets contained within the tube. The fuel pellets are held against the lower end plug by a spring which is supported by a setting structure. The setting structure is maintained at a proper position at the middle of the tube by a wedge effect caused by spring force exerted by the spring against a set of balls coacting with a tapered member of the setting structure thereby wedging the balls against the inner wall of the tube, and the setting structure is moved free by pushing with a push bar against the spring force so as to release the wedge effect

Nuclear fuel tax in court

International Nuclear Information System (INIS)

Leidinger, Tobias

2014-01-01

Besides the 'Nuclear Energy Moratorium' (temporary shutdown of eight nuclear power plants after the Fukushima incident) and the legally decreed 'Nuclear Energy Phase-Out' (by the 13th AtG-amendment), also the legality of the nuclear fuel tax is being challenged in court. After receiving urgent legal proposals from 5 nuclear power plant operators, the Hamburg fiscal court (4V 154/13) temporarily obliged on 14 April 2014 respective main customs offices through 27 decisions to reimburse 2.2 b. Euro nuclear fuel tax to the operating companies. In all respects a remarkable process. It is not in favour of cleverness to impose a political target even accepting immense constitutional and union law risks. Taxation 'at any price' is neither a statement of state sovereignty nor one for a sound fiscal policy. Early and serious warnings of constitutional experts and specialists in the field of tax law with regard to the nuclear fuel tax were not lacking. (orig.)

Nuclear fuel cycle simulation system (VISTA)

International Nuclear Information System (INIS)

2007-02-01

The Nuclear Fuel Cycle Simulation System (VISTA) is a simulation system which estimates long term nuclear fuel cycle material and service requirements as well as the material arising from the operation of nuclear fuel cycle facilities and nuclear power reactors. The VISTA model needs isotopic composition of spent nuclear fuel in order to make estimations of the material arisings from the nuclear reactor operation. For this purpose, in accordance with the requirements of the VISTA code, a new module called Calculating Actinide Inventory (CAIN) was developed. CAIN is a simple fuel depletion model which requires a small number of input parameters and gives results in a very short time. VISTA has been used internally by the IAEA for the estimation of: spent fuel discharge from the reactors worldwide, Pu accumulation in the discharged spent fuel, minor actinides (MA) accumulation in the spent fuel, and in the high level waste (HLW) since its development. The IAEA decided to disseminate the VISTA tool to Member States using internet capabilities in 2003. The improvement and expansion of the simulation code and the development of the internet version was started in 2004. A website was developed to introduce the simulation system to the visitors providing a simple nuclear material flow calculation tool. This website has been made available to Member States in 2005. The development work for the full internet version is expected to be fully available to the interested parties from IAEA Member States in 2007 on its website. This publication is the accompanying text which gives details of the modelling and an example scenario

Nuclear fuel manufacture

International Nuclear Information System (INIS)

Costello, J.M.

1980-09-01

The technologies used to manufacture nuclear fuel from uranium ore are outlined, with particular reference to the light water reactor fuel cycle. Capital and operating cost estimates for the processing stages are given, and the relevance to a developing uranium industry in Australia is discussed

Communications received from certain Member States regarding guidelines for the export of nuclear material, equipment and technology

International Nuclear Information System (INIS)

1994-04-01

The Director General has received notes verbales dated 27 August 1993 and 28 October 1993 from the Permanent Missions of Finland and Spain to the International Atomic Energy relating to the export of nuclear material, equipment and technology. The purpose of these notes verbales is to provide further information on those Governments' nuclear export policies and practices

Nuclear fuel cycle

International Nuclear Information System (INIS)

Niedrig, T.

1987-01-01

Nuclear fuel supply is viewed as a buyer's market of assured medium-term stability. Even on a long-term basis, no shortage is envisaged for all conceivable expansion schedules. The conversion and enrichment facilities developed since the mid-seventies have done much to stabilize the market, owing to the fact that one-sided political decisions by the USA can be counteracted efficiently. In view of the uncertainties concerning realistic nuclear waste management strategies, thermal recycling and mixed oxide fuel elements might increase their market share in the future. Capacities are being planned accordingly. (orig.) [de

Sustainability Features of Nuclear Fuel Cycle Options

Directory of Open Access Journals (Sweden)

Stefano Passerini

2012-09-01

Full Text Available The nuclear fuel cycle is the series of stages that nuclear fuel materials go through in a cradle to grave framework. The Once Through Cycle (OTC is the current fuel cycle implemented in the United States; in which an appropriate form of the fuel is irradiated through a nuclear reactor only once before it is disposed of as waste. The discharged fuel contains materials that can be suitable for use as fuel. Thus, different types of fuel recycling technologies may be introduced in order to more fully utilize the energy potential of the fuel, or reduce the environmental impacts and proliferation concerns about the discarded fuel materials. Nuclear fuel cycle systems analysis is applied in this paper to attain a better understanding of the strengths and weaknesses of fuel cycle alternatives. Through the use of the nuclear fuel cycle analysis code CAFCA (Code for Advanced Fuel Cycle Analysis, the impact of a number of recycling technologies and the associated fuel cycle options is explored in the context of the U.S. energy scenario over 100 years. Particular focus is given to the quantification of Uranium utilization, the amount of Transuranic Material (TRU generated and the economics of the different options compared to the base-line case, the OTC option. It is concluded that LWRs and the OTC are likely to dominate the nuclear energy supply system for the period considered due to limitations on availability of TRU to initiate recycling technologies. While the introduction of U-235 initiated fast reactors can accelerate their penetration of the nuclear energy system, their higher capital cost may lead to continued preference for the LWR-OTC cycle.

Nuclear fuel cycle and legal regulations

International Nuclear Information System (INIS)

Shimoyama, Shunji; Kaneko, Koji.

1980-01-01

Nuclear fuel cycle is regulated as a whole in Japan by the law concerning regulation of nuclear raw materials, nuclear fuel materials and reactors (hereafter referred to as ''the law concerning regulation of reactors''), which was published in 1957, and has been amended 13 times. The law seeks to limit the use of atomic energy to peaceful objects, and nuclear fuel materials are controlled centering on the regulation of enterprises which employ nuclear fuel materials, namely regulating each enterprise. While the permission and report of uses are necessary for the employment of nuclear materials under Article 52 and 61 of the law concerning regulation of reactors, the permission provisions are not applied to three kinds of enterprises of refining, processing and reprocessing and the persons who install reactors as the exceptions in Article 52, when nuclear materials are used for the objects of the enterprises themselves. The enterprises of refining, processing and reprocessing and the persons who install reactors are stipulated respectively in the law. Accordingly the nuclear material regulations are applied only to the users of small quantity of such materials, namely universities, research institutes and hospitals. The nuclear fuel materials used in Japan which are imported under international contracts including the nuclear energy agreements between two countries are mostly covered by the security measures of IAEA as internationally controlled substances. (Okada, K.)

Inhibition of CRM1-mediated nuclear export of transcription factors by leukemogenic NUP98 fusion proteins.

Science.gov (United States)

Takeda, Akiko; Sarma, Nayan J; Abdul-Nabi, Anmaar M; Yaseen, Nabeel R

2010-05-21

NUP98 is a nucleoporin that plays complex roles in the nucleocytoplasmic trafficking of macromolecules. Rearrangements of the NUP98 gene in human leukemia result in the expression of numerous fusion oncoproteins whose effect on nucleocytoplasmic trafficking is poorly understood. The present study was undertaken to determine the effects of leukemogenic NUP98 fusion proteins on CRM1-mediated nuclear export. NUP98-HOXA9, a prototypic NUP98 fusion, inhibited the nuclear export of two known CRM1 substrates: mutated cytoplasmic nucleophosmin and HIV-1 Rev. In vitro binding assays revealed that NUP98-HOXA9 binds CRM1 through the FG repeat motif in a Ran-GTP-dependent manner similar to but stronger than the interaction between CRM1 and its export substrates. Two NUP98 fusions, NUP98-HOXA9 and NUP98-DDX10, whose fusion partners are structurally and functionally unrelated, interacted with endogenous CRM1 in myeloid cells as shown by co-immunoprecipitation. These leukemogenic NUP98 fusion proteins interacted with CRM1, Ran, and the nucleoporin NUP214 in a manner fundamentally different from that of wild-type NUP98. NUP98-HOXA9 and NUP98-DDX10 formed characteristic aggregates within the nuclei of a myeloid cell line and primary human CD34+ cells and caused aberrant localization of CRM1 to these aggregates. These NUP98 fusions caused nuclear accumulation of two transcription factors, NFAT and NFkappaB, that are regulated by CRM1-mediated export. The nuclear entrapment of NFAT and NFkappaB correlated with enhanced transcription from promoters responsive to these transcription factors. Taken together, the results suggest a new mechanism by which NUP98 fusions dysregulate transcription and cause leukemia, namely, inhibition of CRM1-mediated nuclear export with aberrant nuclear retention of transcriptional regulators.

HCTISN: no secret export of nuclear wastes to Russia

International Nuclear Information System (INIS)

Anon.

2010-01-01

Recently a controversy has broken out about the EDF's exports of depleted uranium to Russia. This depleted uranium comes from 2 sources: the tailings of uranium enrichment (from EURODIF plant) and the recycling of spent fuels (from La Hague plant). Depleted uranium is sent to Russia to be enriched by centrifugation process, this enrichment generates new depleted uranium that is kept by Russia, enriched uranium is sent back to France. As it is stipulated in all enrichment contracts the company that operates the enrichment keeps the depleted material, it is the case of Tenex the Russian company. This depleted uranium can not be considered as a waste because it is stored to be used as fuel for future fast reactors. (A.C.)

Nuclear fuel activities in Canada

Energy Technology Data Exchange (ETDEWEB)

Cox, D S [Fuel Development Branch, Chalk River Labs., AECL (Canada)

1997-12-01

Nuclear fuel activities in Canada are considered in the presentation on the following directions: Canadian utility fuel performance; CANDU owner`s group fuel programs; AECL advanced fuel program (high burnup fuel behaviour and development); Pu dispositioning (MOX) activities. 1 tab.

Evaluation of nuclear energy in the context of energy security

International Nuclear Information System (INIS)

Irie, Kazutomo; Kanda, Keiji

2002-01-01

This paper analyzes the view expressed by the Japanese government on the role of nuclear energy for energy security through scrutiny of Japan's policy documents. The analysis revealed that the contribution by nuclear energy to Japan's energy security has been defined in two ways. Nuclear energy improves short-term energy security with its characteristics such as political stability in exporting countries of uranium, easiness of stockpiling of nuclear fuels, stability in power generation cost, and reproduction of plutonium and other fissile material for use by reprocessing of spent fuel. Nuclear energy also contributes to medium- and long-term energy security through its characteristics that fissile material can be reproduced (multiplied in the case of breeder reactor) from spent fuels. Further contribution can be expected by nuclear fusion. Japan's energy security can be strengthened not only by expanding the share of nuclear energy in total energy supply, but also by improving nuclear energy's characteristics which are related to energy security. Policy measures to be considered for such improvement will include (a) policy dialogue with exporting countries of uranium, (b) government assistance to development of uranium mines, (c) nuclear fuel stockpiling, (d) reprocessing and recycling of spent fuels, (e) development of fast breeder reactor, and (f) research of nuclear fusion. (author)

The metalloid arsenite induces nuclear export of Id3 possibly via binding to the N-terminal cysteine residues

International Nuclear Information System (INIS)

Kurooka, Hisanori; Sugai, Manabu; Mori, Kentaro; Yokota, Yoshifumi

2013-01-01

Highlights: •Sodium arsenite induces cytoplasmic accumulation of Id3. •Arsenite binds to closely spaced N-terminal cysteine residues of Id3. •N-terminal cysteines are essential for arsenite-induced nuclear export of Id3. •Nuclear export of Id3 counteracts its transcriptional repression activity. -- Abstract: Ids are versatile transcriptional repressors that regulate cell proliferation and differentiation, and appropriate subcellular localization of the Id proteins is important for their functions. We previously identified distinct functional nuclear export signals (NESs) in Id1 and Id2, but no active NES has been reported in Id3. In this study, we found that treatment with the stress-inducing metalloid arsenite led to the accumulation of GFP-tagged Id3 in the cytoplasm. Cytoplasmic accumulation was impaired by a mutation in the Id3 NES-like sequence resembling the Id1 NES, located at the end of the HLH domain. It was also blocked by co-treatment with the CRM1-specific nuclear export inhibitor leptomycin B (LMB), but not with the inhibitors for mitogen-activated protein kinases (MAPKs). Importantly, we showed that the closely spaced N-terminal cysteine residues of Id3 interacted with the arsenic derivative phenylarsine oxide (PAO) and were essential for the arsenite-induced cytoplasmic accumulation, suggesting that arsenite induces the CRM1-dependent nuclear export of Id3 via binding to the N-terminal cysteines. Finally, we demonstrated that Id3 significantly repressed arsenite-stimulated transcription of the immediate-early gene Egr-1 and that this repression activity was inversely correlated with the arsenite-induced nuclear export. Our results imply that Id3 may be involved in the biological action of arsenite

Development of nuclear fuel cycle technologies - bases of long-term provision of fuel and environmental safety of nuclear power

International Nuclear Information System (INIS)

Solonin, M.I.; Polyakov, A.S.; Zakharkin, B.S.; Smelov, V.S.; Nenarokomov, E.A.; Mukhin, I.V.

2000-01-01

To-day nuclear power is one of the options, however, to-morrow it may become the main source of the energy, thus, providing for the stable economic development for the long time to come. The availability of the large-scale nuclear power in the foreseeable future is governed by not only the safe operation of nuclear power plants (NPP) but also by the environmentally safe management of spent nuclear fuel, radioactive waste conditioning and long-term storage. More emphasis is to be placed to the closing of the fuel cycle in view of substantial quantities of spent nuclear fuel arisings. The once-through fuel cycle that is cost effective at the moment cannot be considered to be environmentally safe even for the middle term since the substantial build-up of spent nuclear fuel containing thousands of tons Pu will require the resolution of the safe management problem in the nearest future and is absolutely unjustified in terms of moral ethics as a transfer of the responsibility to future generations. The minimization of radioactive waste arisings and its radioactivity is only feasible with the closed fuel cycle put into practice and some actinides and long-lived fission radionuclides burnt out. The key issues in providing the environmentally safe fuel cycle are efficient processes of producing fuel for NPP, radionuclide after-burning included, a long-term spent nuclear fuel storage and reprocessing as well as radioactive waste management. The paper deals with the problems inherent in producing fuel for NPP with a view for the closed fuel cycle. Also discussed are options of the fuel cycle, its effectiveness and environmental safety with improvements in technologies of spent nuclear fuel reprocessing and long-lived radionuclide partitioning. (authors)

Development of nuclear fuel cycle technologies - bases of long-term provision of fuel and environmental safety of nuclear power

Energy Technology Data Exchange (ETDEWEB)

Solonin, M I; Polyakov, A S; Zakharkin, B S; Smelov, V S; Nenarokomov, E A; Mukhin, I V [SSC, RF, A.A. Bochvar ALL-Russia Research Institute of Inorganic Materials, Moscow (Russian Federation)

2000-07-01

To-day nuclear power is one of the options, however, to-morrow it may become the main source of the energy, thus, providing for the stable economic development for the long time to come. The availability of the large-scale nuclear power in the foreseeable future is governed by not only the safe operation of nuclear power plants (NPP) but also by the environmentally safe management of spent nuclear fuel, radioactive waste conditioning and long-term storage. More emphasis is to be placed to the closing of the fuel cycle in view of substantial quantities of spent nuclear fuel arisings. The once-through fuel cycle that is cost effective at the moment cannot be considered to be environmentally safe even for the middle term since the substantial build-up of spent nuclear fuel containing thousands of tons Pu will require the resolution of the safe management problem in the nearest future and is absolutely unjustified in terms of moral ethics as a transfer of the responsibility to future generations. The minimization of radioactive waste arisings and its radioactivity is only feasible with the closed fuel cycle put into practice and some actinides and long-lived fission radionuclides burnt out. The key issues in providing the environmentally safe fuel cycle are efficient processes of producing fuel for NPP, radionuclide after-burning included, a long-term spent nuclear fuel storage and reprocessing as well as radioactive waste management. The paper deals with the problems inherent in producing fuel for NPP with a view for the closed fuel cycle. Also discussed are options of the fuel cycle, its effectiveness and environmental safety with improvements in technologies of spent nuclear fuel reprocessing and long-lived radionuclide partitioning. (authors)

Nuclear fuel replacement device

International Nuclear Information System (INIS)

Ritz, W.C.; Robey, R.M.; Wett, J.F.

1984-01-01

A fuel handling arrangement for a liquid metal cooled nuclear reactor having a single rotating plug eccentric to the fuel core and a fuel handling machine radially movable along a slot in the plug with a transfer station disposed outside the fuel core but covered by the eccentric plug and within range of movement of said fuel handling machine to permit transfer of fuel assemblies between the core and the transfer station. (author)

Device for reprocessing nuclear fuels

International Nuclear Information System (INIS)

Hatano, Mamoru.

1981-01-01

Purpose: To readily discharge a nuclear fuel by burning the nuclear fuel as it is without a pulverizing step and removing the graphite and other coated fuel particles. Constitution: An oxygen supply pipe is connected to the lower portion of a discharge chamber having an inlet for the fuel, and an exhaust pipe is connected to the upper portion of the chamber. The fuel mounted on a metallic gripping member made of metallic material is inserted from the inlet, the gripping member is connected through a conductor to a voltage supply unit, oxygen is then supplied through the oxygen supply tube to the discharge chamber, the voltage supply unit is subsequently operated, and discharge takes place among the fuels. Thus, high heat is generated by the discharge, the graphite carbon of the fuel is burnt, silicon carbide is destroyed and decomposed, the isolated nuclear fuel particles are discharged from the exhaust port, and the combustion gas and small embers are exhausted from the exhaust tube. Accordingly, radioactive dusts are not so much generated as when using a mechanical pulverizing means, and prescribed objective can be achieved. (Yoshino, Y.)

Nuclear fuel cycle activities with an utility

International Nuclear Information System (INIS)

Schwarz, E.

1977-01-01

The lecture will deal with the following topics: Fuel requirements: establishing fuel requirements - first core - reloads. Calculation of required uranium and separation work: reload planning - long term - short term - during refuelling; exactness of calculations: contracts: 1) Uranium and conversion; 2) Enrichment services; 3) Fuel elements; 4) Ownership; 5) Accidential loss of material; 6) Flexibility in time and amounts; 7) Specifications, surcharges; 8) Terms of payment; 9) Fuel containers, ownership, retransport; fuel reserves: 1) Natural uranium (concentrates or reserves in the ground); 2) Enriched uranium; 3) Fuel elements; 4) Cost of reserves; 5) Exchange in case of need. Handling of contracts: 1) Schedule for deliveries; Notes for deliveries; 3) Fuel accounting and balance; 4) Formalities (export and import licenses, customs etc.). Fuel cost: 1) Prices; 2) Fuel cost calculations for comparison of bids and cost forecast. (orig.) [de

75 FR 15743 - Application for a License To Export High-Enriched Uranium

Science.gov (United States)

2010-03-30

... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(c) ``Public notice of receipt of an application,'' please take notice that the...-Enriched 160.0 kilograms To fabricate fuel France. Complex, March 3, 2010. Uranium (93.35%). uranium (149...

Reprocessing of nuclear fuels

International Nuclear Information System (INIS)