WorldWideScience

Sample records for nuclear envelope remnants

  1. The Arabidopsis Nuclear Pore and Nuclear Envelope

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    Meier, Iris; Brkljacic, Jelena

    2010-01-01

    The nuclear envelope is a double membrane structure that separates the eukaryotic cytoplasm from the nucleoplasm. The nuclear pores embedded in the nuclear envelope are the sole gateways for macromolecular trafficking in and out of the nucleus. The nuclear pore complexes assembled at the nuclear pores are large protein conglomerates composed of multiple units of about 30 different nucleoporins. Proteins and RNAs traffic through the nuclear pore complexes, enabled by the interacting activities...

  2. Nuclear envelopathies: a complex LINC between nuclear envelope and pathology.

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    Janin, Alexandre; Bauer, Delphine; Ratti, Francesca; Millat, Gilles; Méjat, Alexandre

    2017-08-30

    Since the identification of the first disease causing mutation in the gene coding for emerin, a transmembrane protein of the inner nuclear membrane, hundreds of mutations and variants have been found in genes encoding for nuclear envelope components. These proteins can be part of the inner nuclear membrane (INM), such as emerin or SUN proteins, outer nuclear membrane (ONM), such as Nesprins, or the nuclear lamina, such as lamins A and C. However, they physically interact with each other to insure the nuclear envelope integrity and mediate the interactions of the nuclear envelope with both the genome, on the inner side, and the cytoskeleton, on the outer side. The core of this complex, called LINC (LInker of Nucleoskeleton to Cytoskeleton) is composed of KASH and SUN homology domain proteins. SUN proteins are INM proteins which interact with lamins by their N-terminal domain and with the KASH domain of nesprins located in the ONM by their C-terminal domain.Although most of these proteins are ubiquitously expressed, their mutations have been associated with a large number of clinically unrelated pathologies affecting specific tissues. Moreover, variants in SUN proteins have been found to modulate the severity of diseases induced by mutations in other LINC components or interactors. For these reasons, the diagnosis and the identification of the molecular explanation of "nuclear envelopathies" is currently challenging.The aim of this review is to summarize the human diseases caused by mutations in genes coding for INM proteins, nuclear lamina, and ONM proteins, and to discuss their potential physiopathological mechanisms that could explain the large spectrum of observed symptoms.

  3. The nuclear envelope from basic biology to therapy.

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    Worman, Howard J; Foisner, Roland

    2010-02-01

    The nuclear envelope has long been a focus of basic research for a highly specialized group of cell biologists. More recently, an expanding group of scientists and physicians have developed a keen interest in the nuclear envelope since mutations in the genes encoding lamins and associated proteins have been shown to cause a diverse range of human diseases often called laminopathies or nuclear envelopathies. Most of these diseases have tissue-selective phenotypes, suggesting that the nuclear envelope must function in cell-type- and developmental-stage-specific processes such as chromatin organization, regulation of gene expression, controlled nucleocytoplasmic transport and response to stress in metazoans. On 22-23 April 2009, Professor Christopher Hutchison organized the 4th British Nuclear Envelope Disease and Chromatin Organization meeting at the College of St Hild and St Bede at Durham University, sponsored by the Biochemical Society. In attendance were investigators with one common interest, the nuclear envelope, but with diverse expertise and training in animal and plant cell biology, genetics, developmental biology and medicine. We were each honoured to be keynote speakers. This issue of Biochemical Society Transactions contains papers written by some of the presenters at this scientifically exciting meeting, held in a bucolic setting where the food was tasty and the wine flowed freely. Perhaps at the end of this excellent meeting more questions were raised than answered, which will stimulate future research. However, what became clear is that the nuclear envelope is a cellular structure with critical functions in addition to its traditional role as a barrier separating the nuclear and cytoplasmic compartments in interphase eukaryotic cells.

  4. A novel family of plant nuclear envelope-associated proteins.

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    Pawar, Vidya; Poulet, Axel; Détourné, Gwénaëlle; Tatout, Christophe; Vanrobays, Emmanuel; Evans, David E; Graumann, Katja

    2016-10-01

    This paper describes the characterisation of a new family of higher plant nuclear envelope-associated proteins (NEAPs) that interact with other proteins of the nuclear envelope. In the model plant Arabidopsis thaliana, the family consists of three genes expressed ubiquitously (AtNEAP1-3) and a pseudogene (AtNEAP4). NEAPs consist of extensive coiled-coil domains, followed by a nuclear localisation signal and a C-terminal predicted transmembrane domain. Domain deletion mutants confirm the presence of a functional nuclear localisation signal and transmembrane domain. AtNEAP proteins localise to the nuclear periphery as part of stable protein complexes, are able to form homo- and heteromers, and interact with the SUN domain proteins AtSUN1 and AtSUN2, involved in the linker of nucleoskeleton and cytoskeleton (LINC) complex. An A. thaliana cDNA library screen identified a putative transcription factor called AtbZIP18 as a novel interactor of AtNEAP1, which suggest a connection between NEAP and chromatin. An Atneap1 Atneap3 double-knockout mutant showed reduced root growth, and altered nuclear morphology and chromatin structure. Thus AtNEAPs are suggested as inner nuclear membrane-anchored coiled-coil proteins with roles in maintaining nuclear morphology and chromatin structure. © The Author 2016. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  5. The epigenetics of nuclear envelope organization and disease

    International Nuclear Information System (INIS)

    Schirmer, Eric C.

    2008-01-01

    Mammalian chromosomes and some specific genes have non-random positions within the nucleus that are tissue-specific and heritable. Work in many organisms has shown that genes at the nuclear periphery tend to be inactive and altering their partitioning to the interior results in their activation. Proteins of the nuclear envelope can recruit chromatin with specific epigenetic marks and can also recruit silencing factors that add new epigenetic modifications to chromatin sequestered at the periphery. Together these findings indicate that the nuclear envelope is a significant epigenetic regulator. The importance of this function is emphasized by observations of aberrant distribution of peripheral heterochromatin in several human diseases linked to mutations in NE proteins. These debilitating inherited diseases range from muscular dystrophies to the premature aging progeroid syndromes and the heterochromatin changes are just one early clue for understanding the molecular details of how they work. The architecture of the nuclear envelope provides a unique environment for epigenetic regulation and as such a great deal of research will be required before we can ascertain the full range of its contributions to epigenetics

  6. Torsin Mediates Primary Envelopment of Large Ribonucleoprotein Granules at the Nuclear Envelope

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    Vahbiz Jokhi

    2013-04-01

    Full Text Available A previously unrecognized mechanism through which large ribonucleoprotein (megaRNP granules exit the nucleus is by budding through the nuclear envelope (NE. This mechanism is akin to the nuclear egress of herpes-type viruses and is essential for proper synapse development. However, the molecular machinery required to remodel the NE during this process is unknown. Here, we identify Torsin, an AAA-ATPase that in humans is linked to dystonia, as a major mediator of primary megaRNP envelopment during NE budding. In torsin mutants, megaRNPs accumulate within the perinuclear space, and the messenger RNAs contained within fail to reach synaptic sites, preventing normal synaptic protein synthesis and thus proper synaptic bouton development. These studies begin to establish the cellular machinery underlying the exit of megaRNPs via budding, offer an explanation for the “nuclear blebbing” phenotype found in dystonia models, and provide an important link between Torsin and the synaptic phenotypes observed in dystonia.

  7. Radiation-induced invagination of the nuclear envelope

    International Nuclear Information System (INIS)

    Szekely, J.G.; Copps, T.P.; Morash, B.D.

    1980-01-01

    Using electron microscopy, we have measured radiation-induced invagination of the nuclear envelope of Chinese hamster V-79 and mouse L cells to produce a quantifiable radiation endpoint on a membrane system. In the dose ranges measured (800 to 3000 rad in L cells and 1270 to 5700 rad in V-79 cells), the amount of invagination increased with dose and continued to develop in intact cells for up to 72 hr after the original population was irradiated. Small vacuoles, which sometimes appeared in the nuclei of L cells, were also more numerous in irradiated cells and increased with dose and incubation time in a similar fashion to invagination development

  8. Cytosol-dependent membrane fusion in ER, nuclear envelope and nuclear pore assembly: biological implications.

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    Rafikova, Elvira R; Melikov, Kamran; Chernomordik, Leonid V

    2010-01-01

    Endoplasmic reticulum and nuclear envelope rearrangements after mitosis are often studied in the reconstitution system based on Xenopus egg extract. In our recent work we partially replaced the membrane vesicles in the reconstitution mix with protein-free liposomes to explore the relative contributions of cytosolic and transmembrane proteins. Here we discuss our finding that cytosolic proteins mediate fusion between membranes lacking functional transmembrane proteins and the role of membrane fusion in endoplasmic reticulum and nuclear envelope reorganization. Cytosol-dependent liposome fusion has allowed us to restore, without adding transmembrane nucleoporins, functionality of nuclear pores, their spatial distribution and chromatin decondensation in nuclei formed at insufficient amounts of membrane material and characterized by only partial decondensation of chromatin and lack of nuclear transport. Both the mechanisms and the biological implications of the discovered coupling between spatial distribution of nuclear pores, chromatin decondensation and nuclear transport are discussed.

  9. GTP-binding proteins in rat liver nuclear envelopes

    International Nuclear Information System (INIS)

    Rubins, J.B.; Benditt, J.O.; Dickey, B.F.; Riedel, N.

    1990-01-01

    Nuclear transport as well as reassembly of the nuclear envelope (NE) after completion of mitosis are processes that have been shown to require GTP and ATP. To study the presence and localization of GTP-binding proteins in the NE, we have combined complementary techniques of [alpha-32P]GTP binding to Western-blotted proteins and UV crosslinking of [alpha-32P]GTP with well-established procedures for NE subfractionation. GTP binding to blotted NE proteins revealed five low molecular mass GTP-binding proteins of 26, 25, 24.5, 24, and 23 kDa, and [alpha-32P]GTP photoaffinity labeling revealed major proteins with apparent molecular masses of 140, 53, 47, 33, and 31 kDa. All GTP-binding proteins appear to localize preferentially to the inner nuclear membrane, possibly to the interface between inner nuclear membrane and lamina. Despite the evolutionary conservation between the NE and the rough endoplasmic reticulum, the GTP-binding proteins identified differed between these two compartments. Most notably, the 68- and 30-kDa GTP-binding subunits of the signal recognition particle receptor, which photolabeled with [alpha-32P]GTP in the rough endoplasmic reticulum fraction, were totally excluded from the NE fraction. Conversely, a major 53-kDa photolabeled protein in the NE was absent from rough endoplasmic reticulum. Whereas Western-blotted NE proteins bound GTP specifically, all [alpha-32P]GTP photolabeled proteins could be blocked by competition with ATP, although with a competition profile that differed from that obtained with GTP. In comparative crosslinking studies with [alpha-32P]ATP, we have identified three specific ATP-binding proteins with molecular masses of 160, 78, and 74 kDa. The localization of GTP- and ATP-binding proteins within the NE appears appropriate for their involvement in nuclear transport and in the GTP-dependent fusion of nuclear membranes

  10. Nuclear envelope and genome interactions in cell fate

    Science.gov (United States)

    Talamas, Jessica A.; Capelson, Maya

    2015-01-01

    The eukaryotic cell nucleus houses an organism’s genome and is the location within the cell where all signaling induced and development-driven gene expression programs are ultimately specified. The genome is enclosed and separated from the cytoplasm by the nuclear envelope (NE), a double-lipid membrane bilayer, which contains a large variety of trans-membrane and associated protein complexes. In recent years, research regarding multiple aspects of the cell nucleus points to a highly dynamic and coordinated concert of efforts between chromatin and the NE in regulation of gene expression. Details of how this concert is orchestrated and how it directs cell differentiation and disease are coming to light at a rapid pace. Here we review existing and emerging concepts of how interactions between the genome and the NE may contribute to tissue specific gene expression programs to determine cell fate. PMID:25852741

  11. Shape Transformation of the Nuclear Envelope during Closed Mitosis.

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    Zhu, Qian; Zheng, Fan; Liu, Allen P; Qian, Jin; Fu, Chuanhai; Lin, Yuan

    2016-11-15

    The nuclear envelope (NE) in lower eukaryotes such as Schizosaccharomyces pombe undergoes large morphology changes during closed mitosis. However, which physical parameters are important in governing the shape evolution of the NE, and how defects in the dividing chromosomes/microtubules are reflected in those parameters, are fundamental questions that remain unresolved. In this study, we show that improper separation of chromosomes in genetically deficient cells leads to membrane tethering or asymmetric division in contrast to the formation of two equal-sized daughter nuclei in wild-type cells. We hypothesize that the poleward force is transmitted to the nuclear membrane through its physical contact with the separated sister chromatids at the two spindle poles. A theoretical model is developed to predict the morphology evolution of the NE where key factors such as the work done by the poleward force and bending and surface energies stored in the membrane have been taken into account. Interestingly, the predicted phase diagram, summarizing the dependence of nuclear shape on the size of the load transmission regions, and the pole-to-pole distance versus surface area relationship all quantitatively agree well with our experimental observations, suggesting that this model captures the essential physics involved in closed mitosis. Copyright © 2016 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  12. Bursting the Bubble - Nuclear Envelope Rupture as a Path to Genomic Instability?

    NARCIS (Netherlands)

    Shah, P.; Wolf, K.A.; Lammerding, J.

    2017-01-01

    The nuclear envelope safeguards the genetic material inside the nucleus by separating it from the cytoplasm. Until recently, it was assumed that nuclear envelope (NE) breakdown occurs only in a highly controlled fashion during mitosis when the chromatin is condensed and divided between the daughter

  13. Condensins Exert Force on Chromatin-Nuclear Envelope Tethers to Mediate Nucleoplasmic Reticulum Formation in Drosophila melanogaster

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    Bozler, Julianna; Nguyen, Huy Q.; Rogers, Gregory C.; Bosco, Giovanni

    2014-01-01

    Although the nuclear envelope is known primarily for its role as a boundary between the nucleus and cytoplasm in eukaryotes, it plays a vital and dynamic role in many cellular processes. Studies of nuclear structure have revealed tissue-specific changes in nuclear envelope architecture, suggesting that its three-dimensional structure contributes to its functionality. Despite the importance of the nuclear envelope, the factors that regulate and maintain nuclear envelope shape remain largely unexplored. The nuclear envelope makes extensive and dynamic interactions with the underlying chromatin. Given this inexorable link between chromatin and the nuclear envelope, it is possible that local and global chromatin organization reciprocally impact nuclear envelope form and function. In this study, we use Drosophila salivary glands to show that the three-dimensional structure of the nuclear envelope can be altered with condensin II-mediated chromatin condensation. Both naturally occurring and engineered chromatin-envelope interactions are sufficient to allow chromatin compaction forces to drive distortions of the nuclear envelope. Weakening of the nuclear lamina further enhanced envelope remodeling, suggesting that envelope structure is capable of counterbalancing chromatin compaction forces. Our experiments reveal that the nucleoplasmic reticulum is born of the nuclear envelope and remains dynamic in that they can be reabsorbed into the nuclear envelope. We propose a model where inner nuclear envelope-chromatin tethers allow interphase chromosome movements to change nuclear envelope morphology. Therefore, interphase chromatin compaction may be a normal mechanism that reorganizes nuclear architecture, while under pathological conditions, such as laminopathies, compaction forces may contribute to defects in nuclear morphology. PMID:25552604

  14. Condensins exert force on chromatin-nuclear envelope tethers to mediate nucleoplasmic reticulum formation in Drosophila melanogaster.

    Science.gov (United States)

    Bozler, Julianna; Nguyen, Huy Q; Rogers, Gregory C; Bosco, Giovanni

    2014-12-30

    Although the nuclear envelope is known primarily for its role as a boundary between the nucleus and cytoplasm in eukaryotes, it plays a vital and dynamic role in many cellular processes. Studies of nuclear structure have revealed tissue-specific changes in nuclear envelope architecture, suggesting that its three-dimensional structure contributes to its functionality. Despite the importance of the nuclear envelope, the factors that regulate and maintain nuclear envelope shape remain largely unexplored. The nuclear envelope makes extensive and dynamic interactions with the underlying chromatin. Given this inexorable link between chromatin and the nuclear envelope, it is possible that local and global chromatin organization reciprocally impact nuclear envelope form and function. In this study, we use Drosophila salivary glands to show that the three-dimensional structure of the nuclear envelope can be altered with condensin II-mediated chromatin condensation. Both naturally occurring and engineered chromatin-envelope interactions are sufficient to allow chromatin compaction forces to drive distortions of the nuclear envelope. Weakening of the nuclear lamina further enhanced envelope remodeling, suggesting that envelope structure is capable of counterbalancing chromatin compaction forces. Our experiments reveal that the nucleoplasmic reticulum is born of the nuclear envelope and remains dynamic in that they can be reabsorbed into the nuclear envelope. We propose a model where inner nuclear envelope-chromatin tethers allow interphase chromosome movements to change nuclear envelope morphology. Therefore, interphase chromatin compaction may be a normal mechanism that reorganizes nuclear architecture, while under pathological conditions, such as laminopathies, compaction forces may contribute to defects in nuclear morphology. Copyright © 2015 Bozler et al.

  15. Role of the nuclear envelope in the pathogenesis of age-related bone loss and osteoporosis

    Science.gov (United States)

    Vidal, Christopher; Bermeo, Sandra; Fatkin, Diane; Duque, Gustavo

    2012-01-01

    The nuclear envelope is the most important border in the eukaryotic cell. The role of the nuclear envelope in cell differentiation and function is determined by a constant interaction between the elements of the nuclear envelope and the transcriptional regulators involved in signal transcription pathways. Among those components of the nuclear envelope, there is a growing evidence that changes in the expression of A-type lamins, which are essential components of the nuclear lamina, are associated with age-related changes in bone affecting the capacity of differentiation of mesenchymal stem cells into osteoblasts, favoring adipogenesis and affecting the function and survival of the osteocytes. Overall, as A-type lamins are considered as the 'guardians of the soma', these proteins are also essential for the integrity and quality of the bone and pivotal for the longevity of the musculoskeletal system. PMID:23951459

  16. [Glucose-6-phosphatase from nuclear envelope in rat liver].

    Science.gov (United States)

    González-Mujica, Freddy

    2008-06-01

    Nuclear envelope (NE) and microsomal glucosa-6-phosphatase (G-6-Pase) activities were compared. Intact microsomes were unable to hydrolyze mannose-6-phosphate (M-6-P), on the other hand, intact NE hydrolyzes this substrate. Galactose-6-phosphate showed to be a good substrate for both NE and microsomal enzymes, with similar latency to that obtained with M-6-P using microsomes. In consequence, this substrate was used to measure the NE integrity. The kinetic parameters (Kii and Kis) of the intact NE G-6-Pase for the phlorizin inhibition using glucose-6-phosphate (G-6-P) and M-6-P as substrates, were very similar. The NE T1 transporter was more sensitive to amiloride than the microsomal T1. The microsomal system was more sensitive to N-ethylmalemide (NEM) than the NE and the latter was insensitive to anion transport inhibitors DIDS and SITS, which strongly affect the microsomal enzyme. The above results allowed to postulate the presence of a hexose-6-phosphate transporter in the NE which is able to carry G-6-P and M-6-P, and perhaps other hexose-6-phosphate which could be different from that present in microsomes or, if it is the same, its activity could by modified by the membrane system where it is included. The higher PPi hydrolysis activity of the intact NE G-6-Pase in comparison to the intact microsomal, suggests differences between the Pi/PPi transport (T2) of both systems. The lower sensitivity of the NE G-6-Pase to NEM suggests that the catalytic subunit of this system has some differences with the microsomal isoform.

  17. Structural and functional adaptations of the mammalian nuclear envelope to meet the meiotic requirements.

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    Link, Jana; Jahn, Daniel; Alsheimer, Manfred

    2015-01-01

    Numerous studies in the past years provided definite evidence that the nuclear envelope is much more than just a simple barrier. It rather constitutes a multifunctional platform combining structural and dynamic features to fulfill many fundamental functions such as chromatin organization, regulation of transcription, signaling, but also structural duties like maintaining general nuclear architecture and shape. One additional and, without doubt, highly impressive aspect is the recently identified key function of selected nuclear envelope components in driving meiotic chromosome dynamics, which in turn is essential for accurate recombination and segregation of the homologous chromosomes. Here, we summarize the recent work identifying new key players in meiotic telomere attachment and movement and discuss the latest advances in our understanding of the actual function of the meiotic nuclear envelope.

  18. Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins

    Energy Technology Data Exchange (ETDEWEB)

    Maric, Martina; Haugo, Alison C. [Department of Microbiology, University of Iowa, Iowa City, IA 52242 (United States); Dauer, William [Department of Neurology, University of Michigan, Ann Arbor, MI 48109 (United States); Johnson, David [Department of Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97201 (United States); Roller, Richard J., E-mail: richard-roller@uiowa.edu [Department of Microbiology, University of Iowa, Iowa City, IA 52242 (United States)

    2014-07-15

    Herpesvirus infection reorganizes components of the nuclear lamina usually without loss of integrity of the nuclear membranes. We report that wild-type HSV infection can cause dissolution of the nuclear envelope in transformed mouse embryonic fibroblasts that do not express torsinA. Nuclear envelope breakdown is accompanied by an eight-fold inhibition of virus replication. Breakdown of the membrane is much more limited during infection with viruses that lack the gB and gH genes, suggesting that breakdown involves factors that promote fusion at the nuclear membrane. Nuclear envelope breakdown is also inhibited during infection with virus that does not express UL34, but is enhanced when the US3 gene is deleted, suggesting that envelope breakdown may be enhanced by nuclear lamina disruption. Nuclear envelope breakdown cannot compensate for deletion of the UL34 gene suggesting that mixing of nuclear and cytoplasmic contents is insufficient to bypass loss of the normal nuclear egress pathway. - Highlights: • We show that wild-type HSV can induce breakdown of the nuclear envelope in a specific cell system. • The viral fusion proteins gB and gH are required for induction of nuclear envelope breakdown. • Nuclear envelope breakdown cannot compensate for deletion of the HSV UL34 gene.

  19. Remodeling of the Nuclear Envelope and Lamina during Bovine Preimplantation Development and Its Functional Implications.

    Directory of Open Access Journals (Sweden)

    Jens Popken

    Full Text Available The present study demonstrates a major remodeling of the nuclear envelope and its underlying lamina during bovine preimplantation development. Up to the onset of major embryonic genome activation (MGA at the 8-cell stage nuclei showed a non-uniform distribution of nuclear pore complexes (NPCs. NPCs were exclusively present at sites where DNA contacted the nuclear lamina. Extended regions of the lamina, which were not contacted by DNA, lacked NPCs. In post-MGA nuclei the whole lamina was contacted rather uniformly by DNA. Accordingly, NPCs became uniformly distributed throughout the entire nuclear envelope. These findings shed new light on the conditions which control the integration of NPCs into the nuclear envelope. The switch from maternal to embryonic production of mRNAs was accompanied by multiple invaginations covered with NPCs, which may serve the increased demands of mRNA export and protein import. Other invaginations, as well as interior nuclear segments and vesicles without contact to the nuclear envelope, were exclusively positive for lamin B. Since the abundance of these invaginations and vesicles increased in concert with a massive nuclear volume reduction, we suggest that they reflect a mechanism for fitting the nuclear envelope and its lamina to a shrinking nuclear size during bovine preimplantation development. In addition, a deposit of extranuclear clusters of NUP153 (a marker for NPCs without associated lamin B was frequently observed from the zygote stage up to MGA. Corresponding RNA-Seq data revealed deposits of spliced, maternally provided NUP153 mRNA and little unspliced, newly synthesized RNA prior to MGA, which increased strongly at the initiation of embryonic expression of NUP153 at MGA.

  20. The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis.

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    Jennifer M Friederichs

    2011-11-01

    Full Text Available The budding yeast spindle pole body (SPB is anchored in the nuclear envelope so that it can simultaneously nucleate both nuclear and cytoplasmic microtubules. During SPB duplication, the newly formed SPB is inserted into the nuclear membrane. The mechanism of SPB insertion is poorly understood but likely involves the action of integral membrane proteins to mediate changes in the nuclear envelope itself, such as fusion of the inner and outer nuclear membranes. Analysis of the functional domains of the budding yeast SUN protein and SPB component Mps3 revealed that most regions are not essential for growth or SPB duplication under wild-type conditions. However, a novel dominant allele in the P-loop region, MPS3-G186K, displays defects in multiple steps in SPB duplication, including SPB insertion, indicating a previously unknown role for Mps3 in this step of SPB assembly. Characterization of the MPS3-G186K mutant by electron microscopy revealed severe over-proliferation of the inner nuclear membrane, which could be rescued by altering the characteristics of the nuclear envelope using both chemical and genetic methods. Lipid profiling revealed that cells lacking MPS3 contain abnormal amounts of certain types of polar and neutral lipids, and deletion or mutation of MPS3 can suppress growth defects associated with inhibition of sterol biosynthesis, suggesting that Mps3 directly affects lipid homeostasis. Therefore, we propose that Mps3 facilitates insertion of SPBs in the nuclear membrane by modulating nuclear envelope composition.

  1. Old foes, new understandings: nuclear entry of small non-enveloped DNA viruses.

    Science.gov (United States)

    Fay, Nikta; Panté, Nelly

    2015-06-01

    The nuclear import of viral genomes is an important step of the infectious cycle for viruses that replicate in the nucleus of their host cells. Although most viruses use the cellular nuclear import machinery or some components of this machinery, others have developed sophisticated ways to reach the nucleus. Some of these have been known for some time; however, recent studies have changed our understanding of how some non-enveloped DNA viruses access the nucleus. For example, parvoviruses enter the nucleus through small disruptions of the nuclear membranes and nuclear lamina, and adenovirus tugs at the nuclear pore complex, using kinesin-1, to disassemble their capsids and deliver viral proteins and genomes into the nucleus. Here we review recent findings of the nuclear import strategies of three small non-enveloped DNA viruses, including adenovirus, parvovirus, and the polyomavirus simian virus 40. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. Influence of the bud neck on nuclear envelope fission in Saccharomyces cerevisiae.

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    Melloy, Patricia G; Rose, Mark D

    2017-09-15

    Studies have shown that nuclear envelope fission (karyokinesis) in budding yeast depends on cytokinesis, but not distinguished whether this was a direct requirement, indirect, because of cell cycle arrest, or due to bud neck-localized proteins impacting both processes. To determine the requirements for karyokinesis, we examined mutants conditionally defective for bud emergence and/or nuclear migration. The common mutant phenotype was completion of the nuclear division cycle within the mother cell, but karyokinesis did not occur. In the cdc24 swe1 mutant, at the non-permissive temperature, multiple nuclei accumulated within the unbudded cell, with connected nuclear envelopes. Upon return to the permissive temperature, the cdc24 swe1 mutant initiated bud emergence, but only the nucleus spanning the neck underwent fission suggesting that the bud neck region is important for fission initiation. The neck may be critical for either mechanical reasons, as the contractile ring might facilitate fission, or for regulatory reasons, as the site of a protein network regulating nuclear envelope fission, mitotic exit, and cytokinesis. We also found that 77-85% of pairs of septin mutant nuclei completed nuclear envelope fission. In addition, 27% of myo1Δ mutant nuclei completed karyokinesis. These data suggested that fission is not dependent on mechanical contraction at the bud neck, but was instead controlled by regulatory proteins there. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Relationship between chromatin complexity and nuclear envelope circularity in hippocampal pyramidal neurons

    International Nuclear Information System (INIS)

    Pantic, Igor; Basailovic, Milos; Paunovic, Jovana; Pantic, Senka

    2015-01-01

    Highlights: •We analyzed chromatin structure and nuclear envelope of 200 hippocampal pyramidal neurons. •Fractal and GLCM mathematical parameters were calculated each chromatin structure. •Nuclear shape was quantified by calculating circularity of the nuclear envelope. •Circularity was in significant relationship with chromatin fractal dimension. •Strong correlation was detected between circularity and some GLCM parameters. -- Abstract: In this study we tested the existence and strength of the relationship between circularity of nuclear envelope and mathematical parameters of chromatin structure. Coronal sections of the brain were made in 10 male albino mice. The brain tissue was stained using a modification of Feulgen method for DNA visualization. A total of 200 hippocampal pyramidal neurons (20 per animal) were visualized using DEM 200 High-Speed Color CMOS Chip and Olympus CX21FS1 microscope. Circularity of the nuclear membrane was calculated in ImageJ (NIH, USA) after the nuclear segmentation, based on the freehand selection of the nuclear regions of interest. Circularity was determined from the values of area and perimeter. For each chromatin structure, using fractal and grey level co-occurrence matrix (GLCM) algorithms, we determined the values of fractal dimension, lacunarity, angular second moment, GLCM entropy, inverse difference moment, GLCM correlation, and GLCM contrast. It was found that circularity is in a significant correlation (p < 0.05) with fractal dimension as the main parameter of fractal complexity analysis. Also, circularity was in a very strong relationship (p < 0.001) with certain parameters of grey level co-occurrence matrix such as the angular second moment and GLCM correlation. This is the first study to indicate that nuclear shape is significantly related to mathematical parameters of higher chromatin organization. Also, it seems that circularity of the nuclear envelope is a good predictor of certain features of chromatin

  4. The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation

    DEFF Research Database (Denmark)

    Bermeo, Sandra; Al-Saedi, Ahmed; Kassem, Moustapha

    2017-01-01

    Mutations in MAN1, a protein of the nuclear envelope, cause bone phenotypes characterized by hyperostosis. The mechanism of this pro-osteogenic phenotype remains unknown. We increased and decreased MAN1 expression in mesenchymal stem cells (MSC) upon which standard osteogenic and adipogenic diffe...

  5. Dynamic assembly of brambleberry mediates nuclear envelope fusion during early development.

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    Abrams, Elliott W; Zhang, Hong; Marlow, Florence L; Kapp, Lee; Lu, Sumei; Mullins, Mary C

    2012-08-03

    To accommodate the large cells following zygote formation, early blastomeres employ modified cell divisions. Karyomeres are one such modification, mitotic intermediates wherein individual chromatin masses are surrounded by nuclear envelope; the karyomeres then fuse to form a single mononucleus. We identified brambleberry, a maternal-effect zebrafish mutant that disrupts karyomere fusion, resulting in formation of multiple micronuclei. As karyomeres form, Brambleberry protein localizes to the nuclear envelope, with prominent puncta evident near karyomere-karyomere interfaces corresponding to membrane fusion sites. brambleberry corresponds to an unannotated gene with similarity to Kar5p, a protein that participates in nuclear fusion in yeast. We also demonstrate that Brambleberry is required for pronuclear fusion following fertilization in zebrafish. Our studies provide insight into the machinery required for karyomere fusion and suggest that specialized proteins are necessary for proper nuclear division in large dividing blastomeres. Copyright © 2012 Elsevier Inc. All rights reserved.

  6. Prm3p is a pheromone-induced peripheral nuclear envelope protein required for yeast nuclear fusion.

    Science.gov (United States)

    Shen, Shu; Tobery, Cynthia E; Rose, Mark D

    2009-05-01

    Nuclear membrane fusion is the last step in the mating pathway of the yeast Saccharomyces cerevisiae. We adapted a bioinformatics approach to identify putative pheromone-induced membrane proteins potentially required for nuclear membrane fusion. One protein, Prm3p, was found to be required for nuclear membrane fusion; disruption of PRM3 caused a strong bilateral defect, in which nuclear congression was completed but fusion did not occur. Prm3p was localized to the nuclear envelope in pheromone-responding cells, with significant colocalization with the spindle pole body in zygotes. A previous report, using a truncated protein, claimed that Prm3p is localized to the inner nuclear envelope. Based on biochemistry, immunoelectron microscopy and live cell microscopy, we find that functional Prm3p is a peripheral membrane protein exposed on the cytoplasmic face of the outer nuclear envelope. In support of this, mutations in a putative nuclear localization sequence had no effect on full-length protein function or localization. In contrast, point mutations and deletions in the highly conserved hydrophobic carboxy-terminal domain disrupted both protein function and localization. Genetic analysis, colocalization, and biochemical experiments indicate that Prm3p interacts directly with Kar5p, suggesting that nuclear membrane fusion is mediated by a protein complex.

  7. Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope.

    Directory of Open Access Journals (Sweden)

    Jose M González-Granado

    Full Text Available Nuclear lamins are important structural and functional proteins in mammalian cells, but little is known about the mechanisms and cofactors that regulate their traffic into the nucleus. Here, we demonstrate that trafficking of lamin A, but not lamin B1, and its assembly into the nuclear envelope are regulated by sorting nexin 6 (SNX6, a major component of the retromer that targets proteins and other molecules to specific subcellular locations. SNX6 interacts with lamin A in vitro and in vivo and links it to the outer surface of the endoplasmic reticulum in human and mouse cells. SNX6 transports its lamin A cargo to the nuclear envelope in a process that takes several hours. Lamin A protein levels in the nucleus augment or decrease, respectively, upon gain or loss of SNX6 function. We further show that SNX6-dependent lamin A nuclear import occurs across the nuclear pore complex via a RAN-GTP-dependent mechanism. These results identify SNX6 as a key regulator of lamin A synthesis and incorporation into the nuclear envelope.

  8. Sorting Nexin 6 Enhances Lamin A Synthesis and Incorporation into the Nuclear Envelope

    Science.gov (United States)

    González-Granado, Jose M.; Navarro-Puche, Ana; Molina-Sanchez, Pedro; Blanco-Berrocal, Marta; Viana, Rosa; de Mora, Jaime Font; Andrés, Vicente

    2014-01-01

    Nuclear lamins are important structural and functional proteins in mammalian cells, but little is known about the mechanisms and cofactors that regulate their traffic into the nucleus. Here, we demonstrate that trafficking of lamin A, but not lamin B1, and its assembly into the nuclear envelope are regulated by sorting nexin 6 (SNX6), a major component of the retromer that targets proteins and other molecules to specific subcellular locations. SNX6 interacts with lamin A in vitro and in vivo and links it to the outer surface of the endoplasmic reticulum in human and mouse cells. SNX6 transports its lamin A cargo to the nuclear envelope in a process that takes several hours. Lamin A protein levels in the nucleus augment or decrease, respectively, upon gain or loss of SNX6 function. We further show that SNX6-dependent lamin A nuclear import occurs across the nuclear pore complex via a RAN-GTP-dependent mechanism. These results identify SNX6 as a key regulator of lamin A synthesis and incorporation into the nuclear envelope. PMID:25535984

  9. Calcium signals can freely cross the nuclear envelope in hippocampal neurons: somatic calcium increases generate nuclear calcium transients

    Directory of Open Access Journals (Sweden)

    Bading Hilmar

    2007-07-01

    Full Text Available Abstract Background In hippocampal neurons, nuclear calcium signaling is important for learning- and neuronal survival-associated gene expression. However, it is unknown whether calcium signals generated by neuronal activity at the cell membrane and propagated to the soma can unrestrictedly cross the nuclear envelope to invade the nucleus. The nuclear envelope, which allows ion transit via the nuclear pore complex, may represent a barrier for calcium and has been suggested to insulate the nucleus from activity-induced cytoplasmic calcium transients in some cell types. Results Using laser-assisted uncaging of caged calcium compounds in defined sub-cellular domains, we show here that the nuclear compartment border does not represent a barrier for calcium signals in hippocampal neurons. Although passive diffusion of molecules between the cytosol and the nucleoplasm may be modulated through changes in conformational state of the nuclear pore complex, we found no evidence for a gating mechanism for calcium movement across the nuclear border. Conclusion Thus, the nuclear envelope does not spatially restrict calcium transients to the somatic cytosol but allows calcium signals to freely enter the cell nucleus to trigger genomic events.

  10. Remnant lipoproteins

    DEFF Research Database (Denmark)

    Varbo, Anette; Nordestgaard, Børge G.

    2017-01-01

    Purpose of review: To review recent advances in the field of remnant lipoproteins and remnant cholesterol with a focus on cardiovascular disease risk. Recent findings: In line with previous years' research, current observational, genetic, and mechanistic studies find remnant lipoproteins (defined...... of cardiovascular disease risk reduction through remnant lipoprotein lowering are under way....

  11. Improving nuclear envelope dynamics by EBV BFRF1 facilitates intranuclear component clearance through autophagy.

    Science.gov (United States)

    Liu, Guan-Ting; Kung, Hsiu-Ni; Chen, Chung-Kuan; Huang, Cheng; Wang, Yung-Li; Yu, Cheng-Pu; Lee, Chung-Pei

    2018-02-26

    Although a vesicular nucleocytoplasmic transport system is believed to exist in eukaryotic cells, the features of this pathway are mostly unknown. Here, we report that the BFRF1 protein of the Epstein-Barr virus improves vesicular transport of nuclear envelope (NE) to facilitate the translocation and clearance of nuclear components. BFRF1 expression induces vesicles that selectively transport nuclear components to the cytoplasm. With the use of aggregation-prone proteins as tools, we found that aggregated nuclear proteins are dispersed when these BFRF1-induced vesicles are formed. BFRF1-containing vesicles engulf the NE-associated aggregates, exit through from the NE, and putatively fuse with autophagic vacuoles. Chemical treatment and genetic ablation of autophagy-related factors indicate that autophagosome formation and autophagy-linked FYVE protein-mediated autophagic proteolysis are involved in this selective clearance of nuclear proteins. Remarkably, vesicular transport, elicited by BFRF1, also attenuated nuclear aggregates accumulated in neuroblastoma cells. Accordingly, induction of NE-derived vesicles by BFRF1 facilitates nuclear protein translocation and clearance, suggesting that autophagy-coupled transport of nucleus-derived vesicles can be elicited for nuclear component catabolism in mammalian cells.-Liu, G.-T., Kung, H.-N., Chen, C.-K., Huang, C., Wang, Y.-L., Yu, C.-P., Lee, C.-P. Improving nuclear envelope dynamics by EBV BFRF1 facilitates intranuclear component clearance through autophagy.

  12. The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation.

    Science.gov (United States)

    Bermeo, Sandra; Al-Saedi, Ahmed; Kassem, Moustapha; Vidal, Christopher; Duque, Gustavo

    2017-12-01

    Mutations in MAN1, a protein of the nuclear envelope, cause bone phenotypes characterized by hyperostosis. The mechanism of this pro-osteogenic phenotype remains unknown. We increased and decreased MAN1 expression in mesenchymal stem cells (MSC) upon which standard osteogenic and adipogenic differentiation were performed. MAN1 knockdown increased osteogenesis and mineralization. In contrast, osteogenesis remained stable upon MAN1 overexpression. Regarding a mechanism, we found that low levels of MAN1 facilitated the nuclear accumulation of regulatory smads and smads-related complexes, with a concurrently high expression of nuclear β-Catenin. In addition, we found adipogenesis to be decreased in both conditions, although predominantly affected by MAN1 overexpression. Finally, lamin A, a protein of the nuclear envelope that regulates MSC differentiation, was unaffected by changes in MAN1. In conclusion, our studies demonstrated that lower levels of MAN1 in differentiating MSC are associated with higher osteogenesis and lower adipogenesis. High levels of MAN1 only affected adipogenesis. These effects could have an important role in the understanding of the role of the proteins of the nuclear envelope in bone formation. J. Cell. Biochem. 118: 4425-4435, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  13. Inner nuclear envelope protein SUN1 plays a prominent role in mammalian mRNA export.

    Science.gov (United States)

    Li, Ping; Noegel, Angelika A

    2015-11-16

    Nuclear export of messenger ribonucleoproteins (mRNPs) through the nuclear pore complex (NPC) can be roughly classified into two forms: bulk and specific export, involving an nuclear RNA export factor 1 (NXF1)-dependent pathway and chromosome region maintenance 1 (CRM1)-dependent pathway, respectively. SUN proteins constitute the inner nuclear envelope component of the l I: nker of N: ucleoskeleton and C: ytoskeleton (LINC) complex. Here, we show that mammalian cells require SUN1 for efficient nuclear mRNP export. The results indicate that both SUN1 and SUN2 interact with heterogeneous nuclear ribonucleoprotein (hnRNP) F/H and hnRNP K/J. SUN1 depletion inhibits the mRNP export, with accumulations of both hnRNPs and poly(A)+RNA in the nucleus. Leptomycin B treatment indicates that SUN1 functions in mammalian mRNA export involving the NXF1-dependent pathway. SUN1 mediates mRNA export through its association with mRNP complexes via a direct interaction with NXF1. Additionally, SUN1 associates with the NPC through a direct interaction with Nup153, a nuclear pore component involved in mRNA export. Taken together, our results reveal that the inner nuclear envelope protein SUN1 has additional functions aside from being a central component of the LINC complex and that it is an integral component of the mammalian mRNA export pathway suggesting a model whereby SUN1 recruits NXF1-containing mRNP onto the nuclear envelope and hands it over to Nup153. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  14. Transmission electron microscope studies of the nuclear envelope in Caenorhabditis elegans embryos.

    Science.gov (United States)

    Cohen, Merav; Tzur, Yonatan B; Neufeld, Esther; Feinstein, Naomi; Delannoy, Michael R; Wilson, Katherine L; Gruenbaum, Yosef

    2002-01-01

    Nuclear membranes and nuclear pore complexes (NPCs) are conserved in both animals and plants. However, the lamina composition and the dimensions of NPCs vary between plants, yeast, and vertebrates. In this study, we established a protocol that preserves the structure of Caenorhabditis elegans embryonic cells for high-resolution studies with thin-section transmission electron microscopy (TEM). We show that the NPCs are bigger in C. elegans embryos than in yeast, with dimensions similar to those in higher eukaryotes. We also localized the C. elegans nuclear envelope proteins Ce-lamin and Ce-emerin by pre-embedding gold labeling immunoelectron microscopy. Both proteins are present at or near the inner nuclear membrane. A fraction of Ce-lamin, but not Ce-emerin, is present in the nuclear interior. Removing the nuclear membranes leaves both Ce-lamin and Ce-emerin associated with the chromatin. Eliminating the single lamin protein caused cell death as visualized by characteristic changes in nuclear architecture including condensation of chromatin, clustering of NPCs, membrane blebbing, and the presence of vesicles inside the nucleus. Taken together, these results show evolutionarily conserved protein localization, interactions, and functions of the C. elegans nuclear envelope.

  15. Abnormal nuclear envelopes in the striatum and motor deficits in DYT11 myoclonus-dystonia mouse models

    Science.gov (United States)

    Yokoi, Fumiaki; Dang, Mai T.; Zhou, Tong; Li, Yuqing

    2012-01-01

    DYT11 myoclonus-dystonia (M-D) is a movement disorder characterized by myoclonic jerks with dystonic symptoms and caused by mutations in paternally expressed SGCE, which codes for ɛ-sarcoglycan. Paternally inherited Sgce heterozygous knock-out (KO) mice exhibit motor deficits and spontaneous myoclonus. Abnormal nuclear envelopes have been reported in cellular and mouse models of early-onset DYT1 generalized torsion dystonia; however, the relationship between the abnormal nuclear envelopes and motor symptoms are not clear. Furthermore, it is not known whether abnormal nuclear envelope exists in non-DYT1 dystonia. In the present study, abnormal nuclear envelopes in the striatal medium spiny neurons (MSNs) were found in Sgce KO mice. To analyze whether the loss of ɛ-sarcoglycan in the striatum alone causes abnormal nuclear envelopes, motor deficits or myoclonus, we produced paternally inherited striatum-specific Sgce conditional KO (Sgce sKO) mice and analyzed their phenotypes. Sgce sKO mice exhibited motor deficits in both beam-walking and accelerated rotarod tests, while they did not exhibit abnormal nuclear envelopes, alteration in locomotion, or myoclonus. The results suggest that the loss of ɛ-sarcoglycan in the striatum contributes to motor deficits, while it alone does not produce abnormal nuclear envelopes or myoclonus. Development of therapies targeting the striatum to compensate for the loss of ɛ-sarcoglycan function may rescue the motor deficits in DYT11 M-D patients. PMID:22080833

  16. Abnormal nuclear envelopes in the striatum and motor deficits in DYT11 myoclonus-dystonia mouse models.

    Science.gov (United States)

    Yokoi, Fumiaki; Dang, Mai T; Zhou, Tong; Li, Yuqing

    2012-02-15

    DYT11 myoclonus-dystonia (M-D) is a movement disorder characterized by myoclonic jerks with dystonic symptoms and caused by mutations in paternally expressed SGCE, which codes for ε-sarcoglycan. Paternally inherited Sgce heterozygous knock-out (KO) mice exhibit motor deficits and spontaneous myoclonus. Abnormal nuclear envelopes have been reported in cellular and mouse models of early-onset DYT1 generalized torsion dystonia; however, the relationship between the abnormal nuclear envelopes and motor symptoms are not clear. Furthermore, it is not known whether abnormal nuclear envelope exists in non-DYT1 dystonia. In the present study, abnormal nuclear envelopes in the striatal medium spiny neurons (MSNs) were found in Sgce KO mice. To analyze whether the loss of ε-sarcoglycan in the striatum alone causes abnormal nuclear envelopes, motor deficits or myoclonus, we produced paternally inherited striatum-specific Sgce conditional KO (Sgce sKO) mice and analyzed their phenotypes. Sgce sKO mice exhibited motor deficits in both beam-walking and accelerated rotarod tests, while they did not exhibit abnormal nuclear envelopes, alteration in locomotion, or myoclonus. The results suggest that the loss of ε-sarcoglycan in the striatum contributes to motor deficits, while it alone does not produce abnormal nuclear envelopes or myoclonus. Development of therapies targeting the striatum to compensate for the loss of ε-sarcoglycan function may rescue the motor deficits in DYT11 M-D patients.

  17. Nuclear Facility Isotopic Content (NFIC) Waste Management System to provide input for safety envelope definition

    International Nuclear Information System (INIS)

    Genser, J.R.

    1992-01-01

    The Westinghouse Savannah River Company (WSRC) is aggressively applying environmental remediation and radioactive waste management activities at the US Department of Energy's Savannah River Site (SRS) to ensure compliance with today's challenging governmental laws and regulatory requirements. This report discusses a computer-based Nuclear Facility Isotopic Content (NFIC) Waste Management System developed to provide input for the safety envelope definition and assessment of site-wide facilities. Information was formulated describing the SRS ''Nuclear Facilities'' and their respective bounding inventories of nuclear materials and radioactive waste using the NFIC Waste Management System

  18. THE FAST-ROTATING, LOW-GRAVITY SUBDWARF B STAR EC 22081-1916: REMNANT OF A COMMON ENVELOPE MERGER EVENT

    International Nuclear Information System (INIS)

    Geier, S.; Classen, L.; Heber, U.

    2011-01-01

    Hot subdwarf B stars (sdBs) are evolved core helium-burning stars with very thin hydrogen envelopes. In order to form an sdB, the progenitor has to lose almost all of its hydrogen envelope right at the tip of the red-giant branch. In binary systems, mass transfer to the companion provides the extraordinary mass loss required for their formation. However, apparently single sdBs exist as well and their formation has been unclear for decades. The merger of helium white dwarfs (He-WDs) leading to an ignition of core helium burning or the merger of a helium core and a low-mass star during the common envelope phase have been proposed as processes leading to sdB formation. Here we report the discovery of EC 22081-1916 as a fast-rotating, single sdB star of low gravity. Its atmospheric parameters indicate that the hydrogen envelope must be unusually thick, which is at variance with the He-WD merger scenario, but consistent with a common envelope merger of a low-mass, possibly substellar object with a red-giant core.

  19. Reduction of a 4q35-encoded nuclear envelope protein in muscle differentiation

    International Nuclear Information System (INIS)

    Ostlund, Cecilia; Guan, Tinglu; Figlewicz, Denise A.; Hays, Arthur P.; Worman, Howard J.; Gerace, Larry; Schirmer, Eric C.

    2009-01-01

    Muscular dystrophy and peripheral neuropathy have been linked to mutations in genes encoding nuclear envelope proteins; however, the molecular mechanisms underlying these disorders remain unresolved. Nuclear envelope protein p19A is a protein of unknown function encoded by a gene at chromosome 4q35. p19A levels are significantly reduced in human muscle as cells differentiate from myoblasts to myotubes; however, its levels are not similarly reduced in all differentiation systems tested. Because 4q35 has been linked to facioscapulohumeral muscular dystrophy (FSHD) and some adjacent genes are reportedly misregulated in the disorder, levels of p19A were analyzed in muscle samples from patients with FSHD. Although p19A was increased in most cases, an absolute correlation was not observed. Nonetheless, p19A downregulation in normal muscle differentiation suggests that in the cases where its gene is inappropriately re-activated it could affect muscle differentiation and contribute to disease pathology.

  20. Data on the association of the nuclear envelope protein Sun1 with nucleoli.

    Science.gov (United States)

    Moujaber, Ossama; Omran, Nawal; Kodiha, Mohamed; Pié, Brigitte; Cooper, Ellis; Presley, John F; Stochaj, Ursula

    2017-08-01

    SUN proteins participate in diverse cellular activities, many of which are connected to the nuclear envelope. Recently, the family member SUN1 has been linked to novel biological activities. These include the regulation of nucleoli, intranuclear compartments that assemble ribosomal subunits. We show that SUN1 associates with nucleoli in several mammalian epithelial cell lines. This nucleolar localization is not shared by all cell types, as SUN1 concentrates at the nuclear envelope in ganglionic neurons and non-neuronal satellite cells. Database analyses and Western blotting emphasize the complexity of SUN1 protein profiles in different mammalian cells. We constructed a STRING network which identifies SUN1-related proteins as part of a larger network that includes several nucleolar proteins. Taken together, the current data highlight the diversity of SUN1 proteins and emphasize the possible links between SUN1 and nucleoli.

  1. Reduction of a 4q35-encoded nuclear envelope protein in muscle differentiation

    Energy Technology Data Exchange (ETDEWEB)

    Ostlund, Cecilia [Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032 (United States); Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032 (United States); Guan, Tinglu [Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037 (United States); Figlewicz, Denise A. [Department of Neurology, University of Michigan, Ann Arbor, MI 48109 (United States); Hays, Arthur P. [Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032 (United States); Worman, Howard J. [Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032 (United States); Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032 (United States); Gerace, Larry [Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037 (United States); Schirmer, Eric C., E-mail: e.schirmer@ed.ac.uk [Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037 (United States); Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR (United Kingdom)

    2009-11-13

    Muscular dystrophy and peripheral neuropathy have been linked to mutations in genes encoding nuclear envelope proteins; however, the molecular mechanisms underlying these disorders remain unresolved. Nuclear envelope protein p19A is a protein of unknown function encoded by a gene at chromosome 4q35. p19A levels are significantly reduced in human muscle as cells differentiate from myoblasts to myotubes; however, its levels are not similarly reduced in all differentiation systems tested. Because 4q35 has been linked to facioscapulohumeral muscular dystrophy (FSHD) and some adjacent genes are reportedly misregulated in the disorder, levels of p19A were analyzed in muscle samples from patients with FSHD. Although p19A was increased in most cases, an absolute correlation was not observed. Nonetheless, p19A downregulation in normal muscle differentiation suggests that in the cases where its gene is inappropriately re-activated it could affect muscle differentiation and contribute to disease pathology.

  2. Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins.

    Science.gov (United States)

    Maric, Martina; Haugo, Alison C; Dauer, William; Johnson, David; Roller, Richard J

    2014-07-01

    Herpesvirus infection reorganizes components of the nuclear lamina usually without loss of integrity of the nuclear membranes. We report that wild-type HSV infection can cause dissolution of the nuclear envelope in transformed mouse embryonic fibroblasts that do not express torsinA. Nuclear envelope breakdown is accompanied by an eight-fold inhibition of virus replication. Breakdown of the membrane is much more limited during infection with viruses that lack the gB and gH genes, suggesting that breakdown involves factors that promote fusion at the nuclear membrane. Nuclear envelope breakdown is also inhibited during infection with virus that does not express UL34, but is enhanced when the US3 gene is deleted, suggesting that envelope breakdown may be enhanced by nuclear lamina disruption. Nuclear envelope breakdown cannot compensate for deletion of the UL34 gene suggesting that mixing of nuclear and cytoplasmic contents is insufficient to bypass loss of the normal nuclear egress pathway. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. Control of nuclear β-dystroglycan content is crucial for the maintenance of nuclear envelope integrity and function.

    Science.gov (United States)

    Vélez-Aguilera, Griselda; de Dios Gómez-López, Juan; Jiménez-Gutiérrez, Guadalupe E; Vásquez-Limeta, Alejandra; Laredo-Cisneros, Marco S; Gómez, Pablo; Winder, Steve J; Cisneros, Bulmaro

    2018-02-01

    β-Dystroglycan (β-DG) is a plasma membrane protein that has ability to target to the nuclear envelope (NE) to maintain nuclear architecture. Nevertheless, mechanisms controlling β-DG nuclear localization and the physiological consequences of a failure of trafficking are largely unknown. We show that β-DG has a nuclear export pathway in myoblasts that depends on the recognition of a nuclear export signal located in its transmembrane domain, by CRM1. Remarkably, NES mutations forced β-DG nuclear accumulation resulting in mislocalization and decreased levels of emerin and lamin B1 and disruption of various nuclear processes in which emerin (centrosome-nucleus linkage and β-catenin transcriptional activity) and lamin B1 (cell cycle progression and nucleoli structure) are critically involved. In addition to nuclear export, the lifespan of nuclear β-DG is restricted by its nuclear proteasomal degradation. Collectively our data show that control of nuclear β-DG content by the combination of CRM1 nuclear export and nuclear proteasome pathways is physiologically relevant to preserve proper NE structure and activity. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Analysis of the documents about the core envelopment of nuclear reactor at the Laguna Verde U-1 power plant

    International Nuclear Information System (INIS)

    Zamora R, L.; Medina F, A.

    1999-01-01

    The degradation of internal components at BWR type reactors is an important subject to consider in the performance availability of the power plant. The Wuergassen nuclear reactor license was confiscated due to the presence of cracking in the core envelopment. In consequence it is necessary carrying out a detailed study with the purpose to avoid these problems in the future. This report presents a review and analysis of documents and technical information referring to the core envelopment of a BWR/5/6 and the Laguna Verde Unit 1 nuclear reactor in Mexico. In this document are presented design data, documents about fabrication processes, and manufacturing of core envelopment. (Author)

  5. Three-Dimensional Reconstruction of Nuclear Envelope Architecture Using Dual-Color Metal-Induced Energy Transfer Imaging.

    Science.gov (United States)

    Chizhik, Anna M; Ruhlandt, Daja; Pfaff, Janine; Karedla, Narain; Chizhik, Alexey I; Gregor, Ingo; Kehlenbach, Ralph H; Enderlein, Jörg

    2017-12-26

    The nuclear envelope, comprising the inner and the outer nuclear membrane, separates the nucleus from the cytoplasm and plays a key role in cellular functions. Nuclear pore complexes (NPCs), which are embedded in the nuclear envelope, control transport of macromolecules between the two compartments. Here, using dual-color metal-induced energy transfer (MIET), we determine the axial distance between Lap2β and Nup358 as markers for the inner nuclear membrane and the cytoplasmic side of the NPC, respectively. Using MIET imaging, we reconstruct the 3D profile of the nuclear envelope over the whole basal area, with an axial resolution of a few nanometers. This result demonstrates that optical microscopy can achieve nanometer axial resolution in biological samples and without recourse to complex interferometric approaches.

  6. Cdk1 Activates Pre-Mitotic Nuclear Envelope Dynein Recruitment and Apical Nuclear Migration in Neural Stem cells

    Science.gov (United States)

    Baffet, Alexandre D.; Hu, Daniel J.; Vallee, Richard B.

    2015-01-01

    Summary Dynein recruitment to the nuclear envelope is required for pre-mitotic nucleus-centrosome interactions in nonneuronal cells, and for apical nuclear migration in neural stem cells. In each case, dynein is recruited to the nuclear envelope (NE) specifically during G2, via two nuclear pore-mediated mechanisms involving RanBP2-BicD2 and Nup133-CENP-F. The mechanisms responsible for cell cycle control of this behavior are unknown. We now find that Cdk1 serves as a direct master controller for NE dynein recruitment in neural stem cells and HeLa cells. Cdk1 phosphorylates conserved sites within RanBP2 and activates BicD2 binding and early dynein recruitment. Late recruitment is triggered by a Cdk1-induced export of CENP-F from the nucleus. Forced NE targeting of BicD2 overrides Cdk1 inhibition, fully rescuing dynein recruitment and nuclear migration in neural stem cells. These results reveal how NE dynein recruitment is cell cycle regulated, and identify the trigger mechanism for apical nuclear migration in the brain. PMID:26051540

  7. Glimpsing over the event horizon: evolution of nuclear pores and envelope.

    Science.gov (United States)

    Jékely, Gáspár

    2005-02-01

    The origin of eukaryotes from prokaryotic ancestors is one of the major evolutionary transitions in the history of life. The nucleus, a membrane bound compartment for confining the genome, is a central feature of eukaryotic cells and its origin also has to be a central feature of any workable theory that ventures to explain eukaryotic origins. Recent bioinformatic analyses of components of the nuclear pore complex (NPC), the nuclear envelope (NE), and the nuclear transport systems revealed exciting evolutionary connections (e.g., between NPC and coated vesicles) and provided a useful record of the phyletic distribution and history of NPC and NE components. These analyses allow us to refine theories on the origin and evolution of the nucleus, and consequently, of the eukaryotic cell.

  8. Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body

    Directory of Open Access Journals (Sweden)

    Diana Rüthnick

    2018-05-01

    Full Text Available The main microtubule organizing centre in the unicellular model organisms Saccharomyces cerevisiae and Schizosaccharomyces pompe is the spindle pole body (SPB. The SPB is a multilayer structure, which duplicates exactly once per cell cycle. Unlike higher eukaryotic cells, both yeast model organisms undergo mitosis without breakdown of the nuclear envelope (NE, a so-called closed mitosis. Therefore, in order to simultaneously nucleate nuclear and cytoplasmic MTs, it is vital to embed the SPB into the NE at least during mitosis, similarly to the nuclear pore complex (NPC. This review aims to embrace the current knowledge of the SPB duplication cycle with special emphasis on the critical step of the insertion of the new SPB into the NE.

  9. Loss of the integral nuclear envelope protein SUN1 induces alteration of nucleoli.

    Science.gov (United States)

    Matsumoto, Ayaka; Sakamoto, Chiyomi; Matsumori, Haruka; Katahira, Jun; Yasuda, Yoko; Yoshidome, Katsuhide; Tsujimoto, Masahiko; Goldberg, Ilya G; Matsuura, Nariaki; Nakao, Mitsuyoshi; Saitoh, Noriko; Hieda, Miki

    2016-01-01

    A supervised machine learning algorithm, which is qualified for image classification and analyzing similarities, is based on multiple discriminative morphological features that are automatically assembled during the learning processes. The algorithm is suitable for population-based analysis of images of biological materials that are generally complex and heterogeneous. Here we used the algorithm wndchrm to quantify the effects on nucleolar morphology of the loss of the components of nuclear envelope in a human mammary epithelial cell line. The linker of nucleoskeleton and cytoskeleton (LINC) complex, an assembly of nuclear envelope proteins comprising mainly members of the SUN and nesprin families, connects the nuclear lamina and cytoskeletal filaments. The components of the LINC complex are markedly deficient in breast cancer tissues. We found that a reduction in the levels of SUN1, SUN2, and lamin A/C led to significant changes in morphologies that were computationally classified using wndchrm with approximately 100% accuracy. In particular, depletion of SUN1 caused nucleolar hypertrophy and reduced rRNA synthesis. Further, wndchrm revealed a consistent negative correlation between SUN1 expression and the size of nucleoli in human breast cancer tissues. Our unbiased morphological quantitation strategies using wndchrm revealed an unexpected link between the components of the LINC complex and the morphologies of nucleoli that serves as an indicator of the malignant phenotype of breast cancer cells.

  10. Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells

    Directory of Open Access Journals (Sweden)

    Arantxa Cebrián-Silla

    2017-07-01

    Full Text Available Neural stem cells (B1 astrocytes; NSCs in the adult ventricular-subventricular-zone (V-SVZ originate in the embryo. Surprisingly, recent work has shown that B1 cells remain largely quiescent. They are reactivated postnatally to function as primary progenitors for neurons destined for the olfactory bulb and some corpus callosum oligodendrocytes. The cellular and molecular properties of quiescent B1 cells remain unknown. Here we found that a subpopulation of B1 cells has a unique nuclear envelope invagination specialization similar to envelope-limited chromatin sheets (ELCS, reported in certain lymphocytes and some cancer cells. Using molecular markers, [3H]thymidine birth-dating, and Ara-C, we found that B1 cells with ELCS correspond to quiescent NSCs. ELCS begin forming in embryonic radial glia cells and represent a specific nuclear compartment containing particular epigenetic modifications and telomeres. These results reveal a unique nuclear compartment in quiescent NSCs, which is useful for identifying these primary progenitors and study their gene regulation.

  11. Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis.

    Science.gov (United States)

    Takemoto, Ai; Kawashima, Shigehiro A; Li, Juan-Juan; Jeffery, Linda; Yamatsugu, Kenzo; Elemento, Olivier; Nurse, Paul

    2016-03-15

    Here, we screened a 10,371 library of diverse molecules using a drug-sensitive fission yeast strain to identify compounds which cause defects in chromosome segregation during mitosis. We identified a phosphorium-ylide-based compound Cutin-1 which inhibits nuclear envelope expansion and nuclear elongation during the closed mitosis of fission yeast, and showed that its target is the β-subunit of fatty acid synthase. A point mutation in the dehydratase domain of Fas1 conferred in vivo and in vitro resistance to Cutin-1. Time-lapse photomicrography showed that the bulk of the chromosomes were only transiently separated during mitosis, and nucleoli separation was defective. Subsequently sister chromatids re-associated leading to chromosomal mis-segregation. These segregation defects were reduced when the nuclear volume was increased and were increased when the nuclear volume was reduced. We propose that there needs to be sufficient nuclear volume to allow the nuclear elongation necessary during a closed mitosis to take place for proper chromosome segregation, and that inhibition of fatty acid synthase compromises nuclear elongation and leads to defects in chromosomal segregation. © 2016. Published by The Company of Biologists Ltd.

  12. Kar5p is required for multiple functions in both inner and outer nuclear envelope fusion in Saccharomyces cerevisiae.

    Science.gov (United States)

    Rogers, Jason V; Rose, Mark D

    2014-12-02

    During mating in the budding yeast Saccharomyces cerevisiae, two haploid nuclei fuse via two sequential membrane fusion steps. SNAREs (i.e., soluble N-ethylmaleimide-sensitive factor attachment protein receptors) and Prm3p mediate outer nuclear membrane fusion, but the inner membrane fusogen remains unknown. Kar5p is a highly conserved transmembrane protein that localizes adjacent to the spindle pole body (SPB), mediates nuclear envelope fusion, and recruits Prm3p adjacent to the SPB. To separate Kar5p's functions, we tested localization, Prm3p recruitment, and nuclear fusion efficiency in various kar5 mutants. All domains and the conserved cysteine residues were essential for nuclear fusion. Several kar5 mutant proteins localized properly but did not mediate Prm3p recruitment; other kar5 mutant proteins localized and recruited Prm3p but were nevertheless defective for nuclear fusion, demonstrating additional functions beyond Prm3p recruitment. We identified one Kar5p domain required for SPB localization, which is dependent on the half-bridge protein Mps3p. Electron microscopy revealed a kar5 mutant that arrests with expanded nuclear envelope bridges, suggesting that Kar5p is required after outer nuclear envelope fusion. Finally, a split-GFP assay demonstrated that Kar5p localizes to both the inner and outer nuclear envelope. These insights suggest a mechanism by which Kar5p mediates inner nuclear membrane fusion. Copyright © 2015 Rogers and Rose.

  13. Remnant lipoproteins.

    Science.gov (United States)

    Varbo, Anette; Nordestgaard, Børge G

    2017-08-01

    To review recent advances in the field of remnant lipoproteins and remnant cholesterol with a focus on cardiovascular disease risk. In line with previous years' research, current observational, genetic, and mechanistic studies find remnant lipoproteins (defined in different ways) to be involved in atherosclerosis development and cardiovascular disease risk. High concentrations of remnant cholesterol could explain some of the residual risk of cardiovascular disease seen after LDL cholesterol lowering. This will be increasingly important as populations worldwide become more obese and more have diabetes, both of which elevate remnant cholesterol concentrations. Many smaller scale studies and post hoc analyses show that remnant cholesterol can be lowered by different types of drugs; however, results from large scale studies with the primary aim of reducing cardiovascular disease risk through lowering of remnant cholesterol in individuals with elevated concentrations are still missing, although some are under way. Remnant cholesterol is a risk factor for cardiovascular disease, and can be lowered by different types of drugs; however, large scale studies of cardiovascular disease risk reduction through remnant lipoprotein lowering are under way.

  14. Chromatin influence on the function and formation of the nuclear envelope shown by laser-induced psoralen photoreaction

    International Nuclear Information System (INIS)

    Peterson, S.P.; Berns, M.W.

    1978-01-01

    Potorous tridactylis (PTK 2 ) cells growing in culture were treated with psoralen derivatives and dividing cells were located by phase-contrast microscopy. Psoralens, light-sensitive DNA-photoadducting drugs, were reacted with mitotic chromosomes through exposure to 365-nm light from an argon laser micro-beam system. It was shown that following mitosis and photoreaction, cells without nuclear envelopes were produced when psoralen-treated cells received 60 light pulses over their entire chromosome complement. These 'non-nuclear membrane' cells were found to incorporate [ 3 H]uridine, and to a lesser extent, [ 3 H]thymidine by autoradiography. Reduction of the light exposure by half (30 near-u.v. pulses) over the entire chromosome complement in the presence of psoralen also produced non-nuclear-membrane cells as seen by light microscopy. Further examination of these cells (30 light pulses) by single-cell electron microscopy revealed that unlike the high light exposure (60 near-u.v. pulses), the low light dosage resulted in cells with membrane patches associated with their chromatin. Since neither actinomycin D nor cycloheximide impeded nuclear envelope reformation, the psoralen-DNA reaction is concluded to produce non-nuclear membrane by a mechanism other than transcription or translation inhibition. The association of Golgi with areas of nuclear membrane patches gives indirect evidence of a possible Golgi contribution to the reformation of the nuclear envelope after mitosis. It is concluded that DNA plays a role in envelope reformation. (author)

  15. Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans.

    Science.gov (United States)

    Martino, Lisa; Morchoisne-Bolhy, Stéphanie; Cheerambathur, Dhanya K; Van Hove, Lucie; Dumont, Julien; Joly, Nicolas; Desai, Arshad; Doye, Valérie; Pintard, Lionel

    2017-10-23

    In animal cells, nuclear envelope breakdown (NEBD) is required for proper chromosome segregation. Whereas mitotic kinases have been implicated in NEBD, how they coordinate their activity to trigger this event is unclear. Here, we show that both in human cells and Caenorhabditis elegans, the Polo-like kinase 1 (PLK-1) is recruited to the nuclear pore complexes, just prior to NEBD, through its Polo-box domain (PBD). We provide evidence that PLK-1 localization to the nuclear envelope (NE) is required for efficient NEBD. We identify the central channel nucleoporins NPP-1/Nup58, NPP-4/Nup54, and NPP-11/Nup62 as the critical factors anchoring PLK-1 to the NE in C. elegans. In particular, NPP-1, NPP-4, and NPP-11 primed at multiple Polo-docking sites by Cdk1 and PLK-1 itself physically interact with the PLK-1 PBD. We conclude that nucleoporins play an unanticipated regulatory role in NEBD, by recruiting PLK-1 to the NE thereby facilitating phosphorylation of critical downstream targets. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL)

    DEFF Research Database (Denmark)

    Gjerstorff, Morten F; Rösner, Heike I; Pedersen, Christina B

    2012-01-01

    GAGE proteins are highly similar, primate-specific molecules with unique primary structure and undefined cellular roles. They are restricted to cells of the germ line in adult healthy individuals, but are broadly expressed in a wide range of cancers. In a yeast two-hybrid screen we identified the...... different dsDNA fragments, suggesting sequence-nonspecific binding. Dual association of GAGE family members with GCL at the nuclear envelope inner membrane in cells, and with dsDNA in vitro, implicate GAGE proteins in chromatin regulation in germ cells and cancer cells....... the metazoan transcriptional regulator, Germ cell-less (GCL), as an interaction partner of GAGE12I. GCL directly binds LEM-domain proteins (LAP2β, emerin, MAN1) at the nuclear envelope, and we found that GAGE proteins were recruited to the nuclear envelope inner membrane by GCL. Based on yeast two...

  17. Expression of Leukemia-Associated Nup98 Fusion Proteins Generates an Aberrant Nuclear Envelope Phenotype.

    Science.gov (United States)

    Fahrenkrog, Birthe; Martinelli, Valérie; Nilles, Nadine; Fruhmann, Gernot; Chatel, Guillaume; Juge, Sabine; Sauder, Ursula; Di Giacomo, Danika; Mecucci, Cristina; Schwaller, Jürg

    2016-01-01

    Chromosomal translocations involving the nucleoporin NUP98 have been described in several hematopoietic malignancies, in particular acute myeloid leukemia (AML). In the resulting chimeric proteins, Nup98's N-terminal region is fused to the C-terminal region of about 30 different partners, including homeodomain (HD) transcription factors. While transcriptional targets of distinct Nup98 chimeras related to immortalization are relatively well described, little is known about other potential cellular effects of these fusion proteins. By comparing the sub-nuclear localization of a large number of Nup98 fusions with HD and non-HD partners throughout the cell cycle we found that while all Nup98 chimeras were nuclear during interphase, only Nup98-HD fusion proteins exhibited a characteristic speckled appearance. During mitosis, only Nup98-HD fusions were concentrated on chromosomes. Despite the difference in localization, all tested Nup98 chimera provoked morphological alterations in the nuclear envelope (NE), in particular affecting the nuclear lamina and the lamina-associated polypeptide 2α (LAP2α). Importantly, such aberrations were not only observed in transiently transfected HeLa cells but also in mouse bone marrow cells immortalized by Nup98 fusions and in cells derived from leukemia patients harboring Nup98 fusions. Our findings unravel Nup98 fusion-associated NE alterations that may contribute to leukemogenesis.

  18. The Malleable Nature of the Budding Yeast Nuclear Envelope: Flares, Fusion, and Fenestrations.

    Science.gov (United States)

    Meseroll, Rebecca A; Cohen-Fix, Orna

    2016-11-01

    In eukaryotes, the nuclear envelope (NE) physically separates nuclear components and activities from rest of the cell. The NE also provides rigidity to the nucleus and contributes to chromosome organization. At the same time, the NE is highly dynamic; it must change shape and rearrange its components during development and throughout the cell cycle, and its morphology can be altered in response to mutation and disease. Here we focus on the NE of budding yeast, Saccharomyces cerevisiae, which has several unique features: it remains intact throughout the cell cycle, expands symmetrically during interphase, elongates during mitosis and, expands asymmetrically during mitotic delay. Moreover, its NE is safely breached during mating and when large structures, such as nuclear pore complexes and the spindle pole body, are embedded into its double membrane. The budding yeast NE lacks lamins and yet the nucleus is capable of maintaining a spherical shape throughout interphase. Despite these eccentricities, studies of the budding yeast NE have uncovered interesting, and likely conserved, processes that contribute to NE dynamics. In particular, we discuss the processes that drive and enable NE expansion and the dramatic changes in the NE that lead to extensions and fenestrations. J. Cell. Physiol. 231: 2353-2360, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

  19. Permeabilization of the nuclear envelope following nanosecond pulsed electric field exposure

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, Gary L., E-mail: gary.l.thompson.3@gmail.com [Oak Ridge Institute for Science & Education, Joint Base San Antonio Fort Sam Houston, TX, 78234 (United States); Roth, Caleb C. [Department of Radiological Sciences, University of Texas Health Science Center at San Antonio, TX, 78234 (United States); Kuipers, Marjorie A. [Radio Frequency Radiation Branch, Bioeffects Division, Human Effectiveness Directorate, 711th Human Performance Wing, Air Force Research Laboratory, Joint Base San Antonio Fort Sam Houston, TX, 78234 (United States); Tolstykh, Gleb P. [General Dynamics IT, Joint Base San Antonio Fort Sam Houston, TX, 78234 (United States); Beier, Hope T. [Optical Radiation Branch, Bioeffects Division, Human Effectiveness Directorate, 711th Human Performance Wing, Air Force Research Laboratory, Joint Base San Antonio Fort Sam Houston, TX, 78234 (United States); Ibey, Bennett L. [Radio Frequency Radiation Branch, Bioeffects Division, Human Effectiveness Directorate, 711th Human Performance Wing, Air Force Research Laboratory, Joint Base San Antonio Fort Sam Houston, TX, 78234 (United States)

    2016-01-29

    Permeabilization of cell membranes occurs upon exposure to a threshold absorbed dose (AD) of nanosecond pulsed electric fields (nsPEF). The ultimate, physiological bioeffect of this exposure depends on the type of cultured cell and environment, indicating that cell-specific pathways and structures are stimulated. Here we investigate 10 and 600 ns duration PEF effects on Chinese hamster ovary (CHO) cell nuclei, where our hypothesis is that pulse disruption of the nuclear envelope membrane leads to observed cell death and decreased viability 24 h post-exposure. To observe short-term responses to nsPEF exposure, CHO cells have been stably transfected with two fluorescently-labeled proteins known to be sequestered for cellular chromosomal function within the nucleus – histone-2b (H2B) and proliferating cell nuclear antigen (PCNA). H2B remains associated with chromatin after nsPEF exposure, whereas PCNA leaks out of nuclei permeabilized by a threshold AD of 10 and 600 ns PEF. A downturn in 24 h viability, measured by MTT assay, is observed at the number of pulses required to induce permeabilization of the nucleus. - Highlights: • The ability of nsPEF to damage nuclear structures within cells is investigated. • Leakage of proliferating nuclear antigen from nuclei is induced by nsPEF. • High doses of nsPEF disrupt cortical lamin and cause chromatin decompaction. • Histone H2B remains attached to chromatin following nsPEF exposure. • DNA does not leak out of nsPEF-permeabilized nuclei.

  20. Design of a small nuclear reactor for extending the operational envelope of the Victoria Class Submarine

    International Nuclear Information System (INIS)

    Cole, C.J.P.

    2003-01-01

    The purpose of this research is to conceptually design a small, inherently safe, quasi-homogeneous nuclear reactor that will provide enough power to maintain the hotel load of the Victoria Class Submarine and extend her operational envelope. This research is in its early stages. The purpose of this paper is to outline the background of the research, present results found to date, and indicate the direction of the research over the next two years. The Canadian Forces has recently acquired four U.K. built Upholder Class submarines to replace the ageing Oberon Class submarines purchased in the early 1960's. The Upholders, like the Oberons, are diesel-electric powered. The Upholders were renamed the Victoria Class upon commissioning in Canada. Submarines are strategic military weapons that have several roles including: intelligence gathering, inflicting surprise attacks, controlling shipping lanes and covert operations. For each of these roles the submarine must remain undetected. To remain undetected, it is imperative that the submarine remains submerged. To remain submerged and continue to function, a submarine requires an air-independent power generation system, such as a nuclear reactor. (author)

  1. Vault mobility depends in part on microtubules and vaults can be recruited to the nuclear envelope

    International Nuclear Information System (INIS)

    Zon, Arend van; Mossink, Marieke H.; Houtsmuller, Adriaan B.; Schoester, Martijn; Scheffer, George L.; Scheper, Rik J.; Sonneveld, Pieter; Wiemer, Erik A.C.

    2006-01-01

    Vaults are ribonucleoproteins that may function in intracellular transport processes. We investigated the intracellular distribution and dynamics of vaults in non-small cell lung cancer cells in which vaults are labeled with the green fluorescent protein. Immunofluorescence experiments showed that vaults are dispersed throughout the cytoplasm; a small fraction is found in close proximity to microtubules. Immunoprecipitation experiments corroborated these results showing co-precipitation of MVP and β-tubulin. Using quantitative fluorescence-recovery after photobleaching (FRAP), we demonstrated that vault mobility over longer distances in part depends on intact microtubules; vaults moving slower when microtubules are depolymerized by nocodazole. Biochemical fractionation indicated a small fraction of MVP associated with the nucleus, however, no GFP-tagged vaults could be observed inside the nucleus. We observed an accumulation of vaults at the nuclear envelope upon treatment of cells with the protein synthesis inhibitor cycloheximide. Analysis of nucleo-cytoplasmic transport using a fluorescent substrate containing a classical NLS and NES expressed in MVP +/+ and MVP -/- mouse embryonic fibroblasts indicated no differences in nuclear import/export kinetics, suggesting no role for vaults in these processes. We hypothesize that a subset of vaults moves directionally via microtubules, possibly towards the nucleus

  2. Human Cytomegalovirus Nuclear Egress Proteins Ectopically Expressed in the Heterologous Environment of Plant Cells are Strictly Targeted to the Nuclear Envelope.

    Science.gov (United States)

    Lamm, Christian E; Link, Katrin; Wagner, Sabrina; Milbradt, Jens; Marschall, Manfred; Sonnewald, Uwe

    2016-03-10

    In all eukaryotic cells, the nucleus forms a prominent cellular compartment containing the cell's nuclear genome. Although structurally similar, animal and plant nuclei differ substantially in details of their architecture. One example is the nuclear lamina, a layer of tightly interconnected filament proteins (lamins) underlying the nuclear envelope of metazoans. So far no orthologous lamin genes could be detected in plant genomes and putative lamin-like proteins are only poorly described in plants. To probe for potentially conserved features of metazoan and plant nuclear envelopes, we ectopically expressed the core nuclear egress proteins of human cytomegalovirus pUL50 and pUL53 in plant cells. pUL50 localizes to the inner envelope of metazoan nuclei and recruits the nuclear localized pUL53 to it, forming heterodimers. Upon expression in plant cells, a very similar localization pattern of both proteins could be determined. Notably, pUL50 is specifically targeted to the plant nuclear envelope in a rim-like fashion, a location to which coexpressed pUL53 becomes strictly corecruited from its initial nucleoplasmic distribution. Using pUL50 as bait in a yeast two-hybrid screening, the cytoplasmic re-initiation supporting protein RISP could be identified. Interaction of pUL50 and RISP could be confirmed by coexpression and coimmunoprecipitation in mammalian cells and by confocal laser scanning microscopy in plant cells, demonstrating partial pUL50-RISP colocalization in areas of the nuclear rim and other intracellular compartments. Thus, our study provides strong evidence for conserved structural features of plant and metazoan nuclear envelops and identifies RISP as a potential pUL50-interacting plant protein.

  3. Nuclear planetology: understanding habitable planets as Galactic bulge stellar remnants (black dwarfs) in a Hertzsprung-Russell (HR) diagram

    Science.gov (United States)

    Roller, Goetz

    2016-04-01

    The Hertzsprung-Russell (HR) diagram is one of the most important diagrams in astronomy. In a HR diagram, the luminosity of stars and/or stellar remnants (white dwarf stars, WD's), relative to the luminosity of the sun, is plotted versus their surface temperatures (Teff). The Earth shows a striking similarity in size (radius ≈ 6.370 km) and Teff of its outer core surface (Teff ≈ 3800 K at the core-mantle-boundary) with old WD's (radius ≈ 6.300 km) like WD0346+246 (Teff ≈ 3820 K after ≈ 12.7 Ga [1]), which plot in the HR diagram close to the low-mass extension of the stellar population or main sequence. In the light of nuclear planetology [2], Earth-like planets are regarded as old, down-cooled and differentiated black dwarfs (Fe-C BLD's) after massive decompression, the most important nuclear reactions involved being 56Fe(γ,α)52Cr (etc.), possibly responsible for extreme terrestrial glaciations events ("snowball" Earth), together with (γ,n), (γ,p) and fusion reactions like 12C(α,γ)16O. The latter reaction might have caused oxidation of the planet from inside out. Nuclear planetology is a new research field, tightly constrained by a coupled 187Re-232Th-238U systematics. By means of nuclear/quantum physics and taking the theory of relativity into account, it aims at understanding the thermal and chemical evolution of Fe-C BLD's after gravitational contraction (e.g. Mercury) or Fermi-pressure controlled collapse (e.g. Earth) events after massive decompression, leading possibly to an r-process event, towards the end of their cooling period [2]. So far and based upon 187Re-232Th-238U nuclear geochronometry, the Fe-C BLD hypothesis can successfully explain the global terrestrial MORB 232Th/238U signature [3]. Thus, it may help to elucidate the DM (depleted mantle), EMI (enriched mantle 1), EMII (enriched mantle 2) or HIMU (high U/Pb) reservoirs, and the 187Os/188Os isotopic dichotomy in Archean magmatic rocks and sediments [4]. Here I present a conceptual

  4. Abnormal nuclear envelope in the cerebellar Purkinje cells and impaired motor learning in DYT11 myoclonus-dystonia mouse models.

    Science.gov (United States)

    Yokoi, Fumiaki; Dang, Mai T; Yang, Guang; Li, Jindong; Doroodchi, Atbin; Zhou, Tong; Li, Yuqing

    2012-02-01

    Myoclonus-dystonia (M-D) is a movement disorder characterized by myoclonic jerks with dystonia. DYT11 M-D is caused by mutations in SGCE which codes for ɛ-sarcoglycan. SGCE is maternally imprinted and paternally expressed. Abnormal nuclear envelope has been reported in mouse models of DYT1 generalized torsion dystonia. However, it is not known whether similar alterations occur in DYT11 M-D. We developed a mouse model of DYT11 M-D using paternally inherited Sgce heterozygous knockout (Sgce KO) mice and reported that they had myoclonus and motor coordination and learning deficits in the beam-walking test. However, the specific brain regions that contribute to these phenotypes have not been identified. Since ɛ-sarcoglycan is highly expressed in the cerebellar Purkinje cells, here we examined the nuclear envelope in these cells using a transmission electron microscope and found that they are abnormal in Sgce KO mice. Our results put DYT11 M-D in a growing family of nuclear envelopathies. To analyze the effect of loss of ɛ-sarcoglycan function in the cerebellar Purkinje cells, we produced paternally inherited cerebellar Purkinje cell-specific Sgce conditional knockout (Sgce pKO) mice. Sgce pKO mice showed motor learning deficits, while they did not show abnormal nuclear envelope in the cerebellar Purkinje cells, robust motor deficits, or myoclonus. The results suggest that ɛ-sarcoglycan in the cerebellar Purkinje cells contributes to the motor learning, while loss of ɛ-sarcoglycan in other brain regions may contribute to nuclear envelope abnormality, myoclonus and motor coordination deficits. Copyright © 2011 Elsevier B.V. All rights reserved.

  5. Structural insights into SUN-KASH complexes across the nuclear envelope

    Institute of Scientific and Technical Information of China (English)

    Wenjia Wang; Zhaocai Zhou; Zhubing Shi; Shi Jiao; Cuicui Chen; Huizhen Wang; Guoguang Liu; Qiang Wang; Yun Zhao; Mark I Greene

    2012-01-01

    Linker of the nucleoskeleton and the cytoskeleton (LINC) complexes are composed of SUN and KASH domaincontaining proteins and bridge the inner and outer membranes of the nuclear envelope.LINC complexes play critical roles in nuclear positioning,cell polarization and cellular stiffness.Previously,we reported the homotrimeric structure of human SUN2.We have now determined the crystal structure of the human SUN2-KASH complex.In the complex structure,the SUN domain homotrimer binds to three independent "hook"-like KASH peptides.The overall conformation of the SUN domain in the complex closely resembles the SUN domain in its apo state.A major conformational change involves the AA'-loop of KASH-bound SUN domain,which rearranges to form a mini β-sheet that interacts with the KASH peptide.The PPPT motif of the KASH domain fits tightly into a hydrophobic pocket on the homotrimeric interface of the SUN domain,which we termed the BI-pocket.Moreover,two adjacent protomers of the SUN domain homotrimer sandwich the KASH domain by hydrophobic interaction and hydrogen bonding.Mutations of these binding sites disrupt or reduce the association between the SUN and KASH domains in vitro.In addition,transfection of wild-type,but not mutant,SUN2 promotes cell migration in Ovcar-3 cells.These results provide a structural model of the LINC complex,which is essential for additional study of the physical and functional coupling between the cytoplasm and the nucleoplasm.

  6. Integrating complex functions: coordination of nuclear pore complex assembly and membrane expansion of the nuclear envelope requires a family of integral membrane proteins.

    Science.gov (United States)

    Schneiter, Roger; Cole, Charles N

    2010-01-01

    The nuclear envelope harbors numerous large proteinaceous channels, the nuclear pore complexes (NPCs), through which macromolecular exchange between the cytosol and the nucleoplasm occurs. This double-membrane nuclear envelope is continuous with the endoplasmic reticulum and thus functionally connected to such diverse processes as vesicular transport, protein maturation and lipid synthesis. Recent results obtained from studies in Saccharomyces cerevisiae indicate that assembly of the nuclear pore complex is functionally dependent upon maintenance of lipid homeostasis of the ER membrane. Previous work from one of our laboratories has revealed that an integral membrane protein Apq12 is important for the assembly of functional nuclear pores. Cells lacking APQ12 are viable but cannot grow at low temperatures, have aberrant NPCs and a defect in mRNA export. Remarkably, these defects in NPC assembly can be overcome by supplementing cells with a membrane fluidizing agent, benzyl alcohol, suggesting that Apq12 impacts the flexibility of the nuclear membrane, possibly by adjusting its lipid composition when cells are shifted to a reduced temperature. Our new study now expands these findings and reveals that an essential membrane protein, Brr6, shares at least partially overlapping functions with Apq12 and is also required for assembly of functional NPCs. A third nuclear envelope membrane protein, Brl1, is related to Brr6, and is also required for NPC assembly. Because maintenance of membrane homeostasis is essential for cellular survival, the fact that these three proteins are conserved in fungi that undergo closed mitoses, but are not found in metazoans or plants, may indicate that their functions are performed by proteins unrelated at the primary sequence level to Brr6, Brl1 and Apq12 in cells that disassemble their nuclear envelopes during mitosis.

  7. GAGE cancer-germline antigens bind DNA and are recruited to the nuclear envelope by Germ cell-less

    DEFF Research Database (Denmark)

    Gjerstorff, Morten; Rösner, Heike; Pedersen, Christina Bøg

    GAGE genes encode a highly similar, primate-specific protein family with unique primary structure and undefined roles in germ cells, various fetal cells and cancer cells. We report that GAGE proteins are intrinsically disordered proteins that provide novel interfaces between chromatin and the nuc......GAGE genes encode a highly similar, primate-specific protein family with unique primary structure and undefined roles in germ cells, various fetal cells and cancer cells. We report that GAGE proteins are intrinsically disordered proteins that provide novel interfaces between chromatin...... and the nuclear envelope. Structural analysis by NMR and CD spectroscopy showed GAGE proteins lack distinct secondary or tertiary structure and are therefore intrinsically disordered. In normal cells and cancer cells GAGE proteins localize predominantly in the nucleus; we found GAGE proteins formed stable......) at the nuclear envelope. Furthermore, exogenous and endogenous GAGE proteins were recruited to the nuclear envelope in GCL-overexpressing cells. Gene expression analysis and immunohistochemical staining suggest GAGE proteins and GCL interact physiologically in human cells that express both, including male germ...

  8. Human Cytomegalovirus nuclear egress and secondary envelopment are negatively affected in the absence of cellular p53

    Energy Technology Data Exchange (ETDEWEB)

    Kuan, Man I; O’Dowd, John M.; Chughtai, Kamila; Hayman, Ian; Brown, Celeste J.; Fortunato, Elizabeth A., E-mail: lfort@uidaho.edu

    2016-10-15

    Human Cytomegalovirus (HCMV) infection is compromised in cells lacking p53, a transcription factor that mediates cellular stress responses. In this study we have investigated compromised functional virion production in cells with p53 knocked out (p53KOs). Infectious center assays found most p53KOs released functional virions. Analysis of electron micrographs revealed modestly decreased capsid production in infected p53KOs compared to wt. Substantially fewer p53KOs displayed HCMV-induced infoldings of the inner nuclear membrane (IINMs). In p53KOs, fewer capsids were found in IINMs and in the cytoplasm. The deficit in virus-induced membrane remodeling within the nucleus of p53KOs was mirrored in the cytoplasm, with a disproportionately smaller number of capsids re-enveloped. Reintroduction of p53 substantially recovered these deficits. Overall, the absence of p53 contributed to inhibition of the formation and function of IINMs and re-envelopment of the reduced number of capsids able to reach the cytoplasm. -- Highlights: •The majority of p53KO cells release fewer functional virions than wt cells. •Nucleocapsids do not efficiently exit the nucleus in p53KO cells. •Infoldings of the inner nuclear membrane are not efficiently formed in p53KO cells. •Cytoplasmic capsids are not efficiently re-enveloped in p53KO cells. •Reintroduction of p53 largely ameliorates these phenotypes.

  9. Venture from the Interior-Herpesvirus pUL31 Escorts Capsids from Nucleoplasmic Replication Compartments to Sites of Primary Envelopment at the Inner Nuclear Membrane.

    Science.gov (United States)

    Bailer, Susanne M.

    2017-11-25

    Herpesviral capsid assembly is initiated in the nucleoplasm of the infected cell. Size constraints require that newly formed viral nucleocapsids leave the nucleus by an evolutionarily conserved vescular transport mechanism called nuclear egress. Mature capsids released from the nucleoplasm are engaged in a membrane-mediated budding process, composed of primary envelopment at the inner nuclear membrane and de-envelopment at the outer nuclear membrane. Once in the cytoplasm, the capsids receive their secondary envelope for maturation into infectious virions. Two viral proteins conserved throughout the herpesvirus family, the integral membrane protein pUL34 and the phosphoprotein pUL31, form the nuclear egress complex required for capsid transport from the infected nucleus to the cytoplasm. Formation of the nuclear egress complex results in budding of membrane vesicles revealing its function as minimal virus-encoded membrane budding and scission machinery. The recent structural analysis unraveled details of the heterodimeric nuclear egress complex and the hexagonal coat it forms at the inside of budding vesicles to drive primary envelopment. With this review, I would like to present the capsid-escort-model where pUL31 associates with capsids in nucleoplasmic replication compartments for escort to sites of primary envelopment thereby coupling capsid maturation and nuclear egress.

  10. Herpes simplex virus glycoproteins gB and gH function in fusion between the virion envelope and the outer nuclear membrane.

    Science.gov (United States)

    Farnsworth, Aaron; Wisner, Todd W; Webb, Michael; Roller, Richard; Cohen, Gary; Eisenberg, Roselyn; Johnson, David C

    2007-06-12

    Herpesviruses must traverse the nuclear envelope to gain access to the cytoplasm and, ultimately, to exit cells. It is believed that herpesvirus nucleocapsids enter the perinuclear space by budding through the inner nuclear membrane (NM). To reach the cytoplasm these enveloped particles must fuse with the outer NM and the unenveloped capsids then acquire a second envelope in the trans-Golgi network. Little is known about the process by which herpesviruses virions fuse with the outer NM. Here we show that a herpes simplex virus (HSV) mutant lacking both the two putative fusion glycoproteins gB and gH failed to cross the nuclear envelope. Enveloped virions accumulated in the perinuclear space or in membrane vesicles that bulged into the nucleoplasm (herniations). By contrast, mutants lacking just gB or gH showed only minor or no defects in nuclear egress. We concluded that either HSV gB or gH can promote fusion between the virion envelope and the outer NM. It is noteworthy that fusion associated with HSV entry requires the cooperative action of both gB and gH, suggesting that the two types of fusion (egress versus entry) are dissimilar processes.

  11. Abnormal nuclear envelope in the cerebellar Purkinje cells and impaired motor learning in DYT11 myoclonus-dystonia mouse models

    OpenAIRE

    Yokoi, Fumiaki; Dang, Mai T.; Yang, Guang; Li, JinDong; Doroodchi, Atbin; Zhou, Tong; Li, Yuqing

    2011-01-01

    Myoclonus-dystonia (M-D) is a movement disorder characterized by myoclonic jerks with dystonia. DYT11 M-D is caused by mutations in SGCE which codes for ε-sarcoglycan. SGCE is maternally imprinted and paternally expressed. Abnormal nuclear envelope has been reported in mouse models of DYT1 generalized torsion dystonia. However, it is not known whether similar alterations occur in DYT11 M-D. We developed a mouse model of DYT11 M-D using paternally-inherited Sgce heterozygous knockout (Sgce KO)...

  12. Regulation of nuclear envelope dynamics via APC/C is necessary for the progression of semi-open mitosis in Schizosaccharomyces japonicus.

    Science.gov (United States)

    Aoki, Keita; Shiwa, Yuh; Takada, Hiraku; Yoshikawa, Hirofumi; Niki, Hironori

    2013-09-01

    Three types of mitosis, which are open, closed or semi-open mitosis, function in eukaryotic cells, respectively. The open mitosis involves breakage of the nuclear envelope before nuclear division, whereas the closed mitosis proceeds with an intact nuclear envelope. To understand the mechanism and significance of three types of mitotic division in eukaryotes, we investigated the process of semi-open mitosis, in which the nuclear envelope is only partially broken, in the fission yeast Schizosaccharomyces japonicus. In anaphase-promoting complex/cyclosome (APC/C) mutants of Sz. japonicus, the nuclear envelope remained relatively intact during anaphase, resulting in impaired semi-open mitosis. As a suppressor of apc2 mutant, a mutation of Oar2, which was a 3-oxoacyl-[acyl carrier protein] reductase, was obtained. The level of the Oar2, which had two destruction-box motifs recognized by APC/C, was increased in APC/C mutants. Furthermore, the defective semi-open mitosis observed in an apc2 mutant was restored by mutated oar2+. Based on these findings, we propose that APC/C regulates the dynamics of the nuclear envelope through degradation of Oar2 dependent on APC/C during the metaphase-to-anaphase transition of semi-open mitosis in Sz. japonicus. © 2013 The Authors Genes to Cells © 2013 by the Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd.

  13. Safe operating envelope

    Energy Technology Data Exchange (ETDEWEB)

    Oliva, N [Ontario Hydro, Toronto, ON (Canada)

    1997-12-01

    Safe Operating Envelope is described representing: The outer bound of plant conditions within which day-to-day plant operation must be maintained in order to comply with regulatory requirements, associated safety design criteria and corporate nuclear safety goals. Figs.

  14. Safe operating envelope

    International Nuclear Information System (INIS)

    Oliva, N.

    1997-01-01

    Safe Operating Envelope is described representing: The outer bound of plant conditions within which day-to-day plant operation must be maintained in order to comply with regulatory requirements, associated safety design criteria and corporate nuclear safety goals. Figs

  15. Dual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis.

    Science.gov (United States)

    Wang, Lina; Tu, Zhaowei; Liu, Chao; Liu, Hongbin; Kaldis, Philipp; Chen, Zijiang; Li, Wei

    2018-01-08

    Telomeres integrity is indispensable for chromosomal stability by preventing chromosome erosion and end-to-end fusions. During meiosis, telomeres attach to the inner nuclear envelope and cluster into a highly crowded microenvironment at the bouquet stage, which requires specific mechanisms to protect the telomeres from fusion. Here, we demonstrate that germ cell-specific knockout of a shelterin complex subunit, Trf1, results in arrest of spermatocytes at two different stages. The obliterated telomere-nuclear envelope attachment in Trf1-deficient spermatocytes impairs homologue synapsis and recombination, resulting in a pachytene-like arrest, while the meiotic division arrest might stem from chromosome end-to-end fusion due to the failure of recruiting meiosis specific telomere associated proteins. Further investigations uncovered that TRF1 could directly interact with Speedy A, and Speedy A might work as a scaffold protein to further recruit Cdk2, thus protecting telomeres from fusion at this stage. Together, our results reveal a novel mechanism of TRF1, Speedy A, and Cdk2 in protecting telomere from fusion in a highly crowded microenvironment during meiosis.

  16. Analysis of the documents about the core envelopment of nuclear reactor at the Laguna Verde U-1 power plant; Analisis de documentos de los materiales de la envolvente del nucleo del reactor nuclear de la CLV U-1

    Energy Technology Data Exchange (ETDEWEB)

    Zamora R, L.; Medina F, A. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1999-07-01

    The degradation of internal components at BWR type reactors is an important subject to consider in the performance availability of the power plant. The Wuergassen nuclear reactor license was confiscated due to the presence of cracking in the core envelopment. In consequence it is necessary carrying out a detailed study with the purpose to avoid these problems in the future. This report presents a review and analysis of documents and technical information referring to the core envelopment of a BWR/5/6 and the Laguna Verde Unit 1 nuclear reactor in Mexico. In this document are presented design data, documents about fabrication processes, and manufacturing of core envelopment. (Author)

  17. Herpesvirus gB-induced fusion between the virion envelope and outer nuclear membrane during virus egress is regulated by the viral US3 kinase.

    Science.gov (United States)

    Wisner, Todd W; Wright, Catherine C; Kato, Akihisa; Kawaguchi, Yasushi; Mou, Fan; Baines, Joel D; Roller, Richard J; Johnson, David C

    2009-04-01

    Herpesvirus capsids collect along the inner surface of the nuclear envelope and bud into the perinuclear space. Enveloped virions then fuse with the outer nuclear membrane (NM). We previously showed that herpes simplex virus (HSV) glycoproteins gB and gH act in a redundant fashion to promote fusion between the virion envelope and the outer NM. HSV mutants lacking both gB and gH accumulate enveloped virions in herniations, vesicles that bulge into the nucleoplasm. Earlier studies had shown that HSV mutants lacking the viral serine/threonine kinase US3 also accumulate herniations. Here, we demonstrate that HSV gB is phosphorylated in a US3-dependent manner in HSV-infected cells, especially in a crude nuclear fraction. Moreover, US3 directly phosphorylated the gB cytoplasmic (CT) domain in in vitro assays. Deletion of gB in the context of a US3-null virus did not add substantially to defects in nuclear egress. The majority of the US3-dependent phosphorylation of gB involved the CT domain and amino acid T887, a residue present in a motif similar to that recognized by US3 in other proteins. HSV recombinants lacking gH and expressing either gB substitution mutation T887A or a gB truncated at residue 886 displayed substantial defects in nuclear egress. We concluded that phosphorylation of the gB CT domain is important for gB-mediated fusion with the outer NM. This suggested a model in which the US3 kinase is incorporated into the tegument layer (between the capsid and envelope) in HSV virions present in the perinuclear space. By this packaging, US3 might be brought close to the gB CT tail, leading to phosphorylation and triggering fusion between the virion envelope and the outer NM.

  18. The near boiling reactor: design of a small nuclear reactor for extending the operational envelope of the Victoria Class Submarine

    International Nuclear Information System (INIS)

    Cole, C.; Bonin, H.

    2005-01-01

    A small, inherently safe nuclear reactor that will provide enough power to maintain the hotel load of the Victoria Class Submarine and extend her operational envelope, has been conceptually designed. The final reactor concept, named the Near Boiling (NB) Reactor, employs TRISO fuel particles in Zirconium cladded fuel rods. The reactor is light water moderated and cooled. The core life is specifically designed to coincide with the refit cycle of the Victoria Class Submarine. The reactor employs a simple and reliable control and shut down system that requires little intervention on the part of the submarine's crew. Also, a kinetic model is developed that demonstrates the inherent safety features of the reactor during several accident scenarios. (author)

  19. The near boiling reactor: design of a small nuclear reactor for extending the operational envelope of the Victoria Class Submarine

    Energy Technology Data Exchange (ETDEWEB)

    Cole, C.; Bonin, H. [Royal Military College of Canada, Dept. of Chemistry and Chemical Engineering, Kingston, Ontario (Canada)]. E-mail: chris.cole@rmc.ca; bonin-h@rmc.ca

    2005-07-01

    A small, inherently safe nuclear reactor that will provide enough power to maintain the hotel load of the Victoria Class Submarine and extend her operational envelope, has been conceptually designed. The final reactor concept, named the Near Boiling (NB) Reactor, employs TRISO fuel particles in Zirconium cladded fuel rods. The reactor is light water moderated and cooled. The core life is specifically designed to coincide with the refit cycle of the Victoria Class Submarine. The reactor employs a simple and reliable control and shut down system that requires little intervention on the part of the submarine's crew. Also, a kinetic model is developed that demonstrates the inherent safety features of the reactor during several accident scenarios. (author)

  20. Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

    NARCIS (Netherlands)

    De Vos, W.H.; Houben, F.; Kamps, M.; Malhas, A.; Verheyen, F.; Cox, J.; Manders, E.M.M.; Verstraeten, V.L.R.M.; van Steensel, M.A.M.; Marcelis, C.L.M.; van den Wijngaard, A.; Vaux, D.J.; Ramaekers, F.C.S.; Broers, J.L.V.

    2011-01-01

    The nuclear lamina provides structural support to the nucleus and has a central role in nuclear organization and gene regulation. Defects in its constituents, the lamins, lead to a class of genetic diseases collectively referred to as laminopathies. Using live cell imaging, we observed the

  1. NSF- and SNARE-mediated membrane fusion is required for nuclear envelope formation and completion of nuclear pore complex assembly in Xenopus laevis egg extracts.

    Science.gov (United States)

    Baur, Tina; Ramadan, Kristijan; Schlundt, Andreas; Kartenbeck, Jürgen; Meyer, Hemmo H

    2007-08-15

    Despite the progress in understanding nuclear envelope (NE) reformation after mitosis, it has remained unclear what drives the required membrane fusion and how exactly this is coordinated with nuclear pore complex (NPC) assembly. Here, we show that, like other intracellular fusion reactions, NE fusion in Xenopus laevis egg extracts is mediated by SNARE proteins that require activation by NSF. Antibodies against Xenopus NSF, depletion of NSF or the dominant-negative NSF(E329Q) variant specifically inhibited NE formation. Staging experiments further revealed that NSF was required until sealing of the envelope was completed. Moreover, excess exogenous alpha-SNAP that blocks SNARE function prevented membrane fusion and caused accumulation of non-flattened vesicles on the chromatin surface. Under these conditions, the nucleoporins Nup107 and gp210 were fully recruited, whereas assembly of FxFG-repeat-containing nucleoporins was blocked. Together, we define NSF- and SNARE-mediated membrane fusion events as essential steps during NE formation downstream of Nup107 recruitment, and upstream of membrane flattening and completion of NPC assembly.

  2. Nanoscale invaginations of the nuclear envelope: Shedding new light on wormholes with elusive function.

    Science.gov (United States)

    Schoen, Ingmar; Aires, Lina; Ries, Jonas; Vogel, Viola

    2017-09-03

    Recent advances in fluorescence microscopy have opened up new possibilities to investigate chromosomal and nuclear 3D organization on the nanoscale. We here discuss their potential for elucidating topographical details of the nuclear lamina. Single molecule localization microscopy (SMLM) in combination with immunostainings of lamina proteins readily reveals tube-like invaginations with a diameter of 100-500 nm. Although these invaginations have been established as a frequent and general feature of interphase nuclei across different cell types, their formation mechanism and function have remained largely elusive. We critically review the current state of research, propose possible connections to lamina associated domains (LADs), and revisit the discussion about the potential role of these invaginations for accelerating mRNA nuclear export. Illustrative studies using 3D super-resolution imaging are shown and will be instrumental to decipher the physiological role of these nanoscale invaginations.

  3. Zeeman perturbed nuclear quadrupole spin echo envelope modulations for spin 3/2 nuclei in polycrystalline specimens

    Science.gov (United States)

    Ramachandran, R.; Narasimhan, P. T.

    The results of theoretical and experimental studies of Zeeman-perturbed nuclear quadrupole spin echo envelope modulations (ZSEEM) for spin 3/2 nuclei in polycrystalline specimens are presented. The response of the Zeeman-perturbed spin ensemble to resonant two pulse excitations has been calculated using the density matrix formalism. The theoretical calculation assumes a parallel orientation of the external r.f. and static Zeeman fields and an arbitrary orientation of these fields to the principal axes system of the electric field gradient. A numerical powder averaging procedure has been adopted to simulate the response of the polycrystalline specimens. Using a coherent pulsed nuclear quadrupole resonance spectrometer the ZSEEM patterns of the 35Cl nuclei have been recorded in polycrystalline specimens of potassium chlorate, barium chlorate, mercuric chloride (two sites) and antimony trichloride (two sites) using the π/2-τ-π/2 sequence. The theoretical and experimental ZSEEM patterns have been compared. In the case of mercuric chloride, the experimental 35Cl ZSEEM patterns are found to be nearly identical for the two sites and correspond to a near-zero value of the asymmetry parameter, η, of the electric field gradient tensor. The difference in the η values for the two 35Cl sites (η ˜0·06 and η˜0·16) in antimony trichloride is clearly reflected in the experimental and theoretical ZSEEM patterns. The present study indicates the feasibility of evaluating η for spin 3/2 nuclei in polycrystalline specimens from ZSEEM investigations.

  4. Protein Targeting: ER Leads the Way to the Inner Nuclear Envelope.

    Science.gov (United States)

    Blackstone, Craig

    2017-12-04

    Efficient targeting of newly synthesized membrane proteins from the endoplasmic reticulum to the inner nuclear membrane depends on nucleotide hydrolysis. A new study shows that this dependence reflects critical actions of the atlastin family of GTPases in maintaining the morphology of the endoplasmic reticulum network. Published by Elsevier Ltd.

  5. Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells.

    Science.gov (United States)

    Gimpel, Petra; Lee, Yin Loon; Sobota, Radoslaw M; Calvi, Alessandra; Koullourou, Victoria; Patel, Rutti; Mamchaoui, Kamel; Nédélec, François; Shackleton, Sue; Schmoranzer, Jan; Burke, Brian; Cadot, Bruno; Gomes, Edgar R

    2017-10-09

    The nucleus is the main microtubule-organizing center (MTOC) in muscle cells due to the accumulation of centrosomal proteins and microtubule (MT) nucleation activity at the nuclear envelope (NE) [1-4]. The relocalization of centrosomal proteins, including Pericentrin, Pcm1, and γ-tubulin, depends on Nesprin-1, an outer nuclear membrane (ONM) protein that connects the nucleus to the cytoskeleton via its N-terminal region [5-7]. Nesprins are also involved in the recruitment of kinesin to the NE and play a role in nuclear positioning in skeletal muscle cells [8-12]. However, a function for MT nucleation from the NE in nuclear positioning has not been established. Using the proximity-dependent biotin identification (BioID) method [13, 14], we found several centrosomal proteins, including Akap450, Pcm1, and Pericentrin, whose association with Nesprin-1α is increased in differentiated myotubes. We show that Nesprin-1α recruits Akap450 to the NE independently of kinesin and that Akap450, but not other centrosomal proteins, is required for MT nucleation from the NE. Furthermore, we demonstrate that this mechanism is disrupted in congenital muscular dystrophy patient myotubes carrying a nonsense mutation within the SYNE1 gene (23560 G>T) encoding Nesprin-1 [15, 16]. Finally, using computer simulation and cell culture systems, we provide evidence for a role of MT nucleation from the NE on nuclear spreading in myotubes. Our data thus reveal a novel function for Nesprin-1α/Nesprin-1 in nuclear positioning through recruitment of Akap450-mediated MT nucleation activity to the NE. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

  6. Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope.

    Science.gov (United States)

    Tsai, Shang-Yi A; Chuang, Jian-Ying; Tsai, Meng-Shan; Wang, Xiao-Fei; Xi, Zheng-Xiong; Hung, Jan-Jong; Chang, Wen-Chang; Bonci, Antonello; Su, Tsung-Ping

    2015-11-24

    The sigma-1 receptor (Sig-1R) chaperone at the endoplasmic reticulum (ER) plays important roles in cellular regulation. Here we found a new function of Sig-1R, in that it translocates from the ER to the nuclear envelope (NE) to recruit chromatin-remodeling molecules and regulate the gene transcription thereof. Sig-1Rs mainly reside at the ER-mitochondrion interface. However, on stimulation by agonists such as cocaine, Sig-1Rs translocate from ER to the NE, where Sig-1Rs bind NE protein emerin and recruit chromatin-remodeling molecules, including lamin A/C, barrier-to-autointegration factor (BAF), and histone deacetylase (HDAC), to form a complex with the gene repressor specific protein 3 (Sp3). Knockdown of Sig-1Rs attenuates the complex formation. Cocaine was found to suppress the gene expression of monoamine oxidase B (MAOB) in the brain of wild-type but not Sig-1R knockout mouse. A single dose of cocaine (20 mg/kg) in rats suppresses the level of MAOB at nuclear accumbens without affecting the level of dopamine transporter. Daily injections of cocaine in rats caused behavioral sensitization. Withdrawal from cocaine in cocaine-sensitized rats induced an apparent time-dependent rebound of the MAOB protein level to about 200% over control on day 14 after withdrawal. Treatment of cocaine-withdrawn rats with the MAOB inhibitor deprenyl completely alleviated the behavioral sensitization to cocaine. Our results demonstrate a role of Sig-1R in transcriptional regulation and suggest cocaine may work through this newly discovered genomic action to achieve its addictive action. Results also suggest the MAOB inhibitor deprenyl as a therapeutic agent to block certain actions of cocaine during withdrawal.

  7. Induction of polyploidy by nuclear fusion mechanism upon decreased expression of the nuclear envelope protein LAP2β in the human osteosarcoma cell line U2OS.

    Science.gov (United States)

    Ben-Shoshan, Shirley Oren; Simon, Amos J; Jacob-Hirsch, Jasmine; Shaklai, Sigal; Paz-Yaacov, Nurit; Amariglio, Ninette; Rechavi, Gideon; Trakhtenbrot, Luba

    2014-01-28

    Polyploidy has been recognized for many years as an important hallmark of cancer cells. Polyploid cells can arise through cell fusion, endoreplication and abortive cell cycle. The inner nuclear membrane protein LAP2β plays key roles in nuclear envelope breakdown and reassembly during mitosis, initiation of replication and transcriptional repression. Here we studied the function of LAP2β in the maintenance of cell ploidy state, a role which has not yet been assigned to this protein. By knocking down the expression of LAP2β, using both viral and non-viral RNAi approaches in osteosarcoma derived U2OS cells, we detected enlarged nuclear size, nearly doubling of DNA content and chromosomal duplications, as analyzed by fluorescent in situ hybridization and spectral karyotyping methodologies. Spectral karyotyping analyses revealed that near-hexaploid karyotypes of LAP2β knocked down cells consisted of not only seven duplicated chromosomal markers, as could be anticipated by genome duplication mechanism, but also of four single chromosomal markers. Furthermore, spectral karyotyping analysis revealed that both of two near-triploid U2OS sub-clones contained the seven markers that were duplicated in LAP2β knocked down cells, whereas the four single chromosomal markers were detected only in one of them. Gene expression profiling of LAP2β knocked down cells revealed that up to a third of the genes exhibiting significant changes in their expression are involved in cancer progression. Our results suggest that nuclear fusion mechanism underlies the polyploidization induction upon LAP2β reduced expression. Our study implies on a novel role of LAP2β in the maintenance of cell ploidy status. LAP2β depleted U2OS cells can serve as a model to investigate polyploidy and aneuploidy formation by nuclear fusion mechanism and its involvement in cancerogenesis.

  8. Building envelope

    CSIR Research Space (South Africa)

    Gibberd, Jeremy T

    2009-01-01

    Full Text Available for use in the building. This is done through photovoltaic and solar water heating panels and wind turbines. Ideally these are integrated in the design of the building envelope to improve the aesthetic quality of the building and minimise material... are naturally ventilated. Renewable energy The building envelope includes renewable energy generation such as photovoltaics, wind turbines and solar water heaters and 10% of the building’s energy requirements are generated from these sources. Views All...

  9. Biomimetic Envelopes

    OpenAIRE

    Ilaria Mazzoleni

    2010-01-01

    How to translate the lessons learned from the analysis and observation of the animal world is the design learning experience presented in this article. Skin is a complex and incredibly sophisticated organ that performs various functions, including protection, sensation and heat and water regulation. In a similar way building envelopes serve multiple roles, as they are the interface between the building inhabitants and environmental elements. The resulting architectural building envelopes prot...

  10. Electrophoretic characterization of the Mammalian nuclear matrix proteome, nuclear envelope, nucleoli and covalently bound ADP-ribose polymers: potential applications to cancer.

    Science.gov (United States)

    Aranda, Xavier G; Racho, Ronald G; Pacheco-Rodríguez, Gustavo; Alvarez-González, Rafael

    2014-01-01

    Nucleic acid metabolism is biochemically compartmentalized to the nucleus. Thus, it is necessary to define the proteome of the various macromolecular structures within this organelle. We isolated the nuclear matrix (NM) fraction from rat liver by sequential centrifugation steps at 13,000 rpm, staggered between endogenous nuclease treatment for 2 h at 37°C, followed by high-salt (H.S.; 2.0 M NaCl) and non-ionic detergent extractions (0.1%- or 1.0% Triton X-100) to eliminate the bulk of chromosomal DNA/RNA, histone proteins and the nuclear envelope (NE). Integrity of the NM and NE structures was confirmed by electron microscopy. Next, we analyzed the NM proteome on a 20% polyacrylamide gel using the PhastSystem. We observed the absence of histone proteins and the characteristic presence of the lamins by Coomassie blue staining. By contrast, upon silver staining, following electrophoretic separation with a Tris-Borate-EDTA buffer, we observed the NM-associated nucleic RNA and protein-free ADP-ribose polymers. While polymers are found in much lower concentration than RNA in NM, they were purified by affinity chromatography on boronate resin prior to electrophoresis. We observed the electrophoretic resolution of free ADP-ribose chains (5-25 units) by silver staining. The significance of our observations to cancer studies and carcinogenesis is discussed. Copyright© 2014, International Institute of Anticancer Research (Dr. John G. Delinasios), All rights reserved.

  11. Autoantibodies from primary biliary cirrhosis patients with anti-p95c antibodies bind to recombinant p97/VCP and inhibit in vitro nuclear envelope assembly

    Science.gov (United States)

    MIYACHI, K; HIRANO, Y; HORIGOME, T; MIMORI, T; MIYAKAWA, H; ONOZUKA, Y; SHIBATA, M; HIRAKATA, M; SUWA, A; HOSAKA, H; MATSUSHIMA, S; KOMATSU, T; MATSUSHIMA, H; HANKINS, R W; FRITZLER, M J

    2004-01-01

    We have reported previously that p95c, a novel 95-kDa cytosolic protein, was the target of autoantibodies in sera of patients with autoimmune hepatic diseases. We studied 30 sera that were shown previously to immunoprecipitate a 95 kDa protein from [35S]-methionine-labelled HeLa lysates and had a specific precipitin band in immunodiffusion. Thirteen sera were available to test the ability of p95c antibodies to inhibit nuclear envelope assembly in an in vitro assay in which confocal fluorescence microscopy was also used to identify the stages at which nuclear assembly was inhibited. The percentage inhibition of nuclear envelope assembly of the 13 sera ranged from 7% to 99% and nuclear envelope assembly and the swelling of nucleus was inhibited at several stages. The percentage inhibition of nuclear assembly was correlated with the titre of anti-p95c as determined by immunodiffusion. To confirm the identity of this autoantigen, we used a full-length cDNA of the p97/valosin-containing protein (VCP) to produce a radiolabelled recombinant protein that was then used in an immunoprecipitation (IP) assay. Our study demonstrated that 12 of the 13 (93%) human sera with antibodies to p95c immunoprecipitated recombinant p97/VCP. Because p95c and p97 have similar molecular masses and cell localization, and because the majority of sera bind recombinant p97/VCP and anti-p95c antibodies inhibit nuclear assembly, this is compelling evidence that p95c and p97/VCP are identical. PMID:15147362

  12. Remnant lipoproteins and atherosclerosis

    NARCIS (Netherlands)

    Twickler, Th. B.; Dallinga-Thie, G. M.; Chapman, M. J.; Cohn, J. S.

    2005-01-01

    A recently developed assay for quantification of remnant-like particle cholesterol has provided considerable evidence that reinforces the concept that elevated levels of plasma remnants are associated with increased cardiovascular disease in different populations and distinct patient groups. In this

  13. SEPT12/SPAG4/LAMINB1 complexes are required for maintaining the integrity of the nuclear envelope in postmeiotic male germ cells.

    Science.gov (United States)

    Yeh, Chung-Hsin; Kuo, Pao-Lin; Wang, Ya-Yun; Wu, Ying-Yu; Chen, Mei-Feng; Lin, Ding-Yen; Lai, Tsung-Hsuan; Chiang, Han-Sun; Lin, Ying-Hung

    2015-01-01

    Male infertility affects approximately 50% of all infertile couples. The male-related causes of intracytoplasmic sperm injection failure include the absence of sperm, immotile or immature sperm, and sperm with structural defects such as those caused by premature chromosomal condensation and DNA damage. Our previous studies based on a knockout mice model indicated that SEPT12 proteins are critical for the terminal morphological formation of sperm. SEPT12 mutations in men result in teratozospermia and oligozospermia. In addition, the spermatozoa exhibit morphological defects of the head and tail, premature chromosomal condensation, and nuclear damage. However, the molecular functions of SEPT12 during spermatogenesis remain unclear. To determine the molecular functions of SEPT12, we applied a yeast 2-hybrid system to identify SEPT12 interactors. Seven proteins that interact with SEPT12 were identified: SEPT family proteins (SEPT4 and SEPT6), nuclear or nuclear membrane proteins (protamine 2, sperm-associated antigen 4, and NDC1 transmembrane nucleoproine), and sperm-related structural proteins (pericentriolar material 1 and obscurin-like 1). Sperm-associated antigen 4 (SPAG4; also known as SUN4) belongs to the SUN family of proteins and acts as a linker protein between nucleoskeleton and cytoskeleton proteins and localizes in the nuclear membrane. We determined that SEPT12 interacts with SPAG4 in a male germ cell line through coimmunoprecipitation. During human spermiogenesis, SEPT12 is colocalized with SPAG4 near the nuclear periphery in round spermatids and in the centrosome region in elongating spermatids. Furthermore, we observed that SEPT12/SPAG4/LAMINB1 formed complexes and were coexpressed in the nuclear periphery of round spermatids. In addition, mutated SEPT12, which was screened from an infertile man, affected the integration of these nuclear envelope complexes through coimmunoprecipitation. This was the first study that suggested that SEPT proteins link to

  14. SEPT12/SPAG4/LAMINB1 complexes are required for maintaining the integrity of the nuclear envelope in postmeiotic male germ cells.

    Directory of Open Access Journals (Sweden)

    Chung-Hsin Yeh

    Full Text Available Male infertility affects approximately 50% of all infertile couples. The male-related causes of intracytoplasmic sperm injection failure include the absence of sperm, immotile or immature sperm, and sperm with structural defects such as those caused by premature chromosomal condensation and DNA damage. Our previous studies based on a knockout mice model indicated that SEPT12 proteins are critical for the terminal morphological formation of sperm. SEPT12 mutations in men result in teratozospermia and oligozospermia. In addition, the spermatozoa exhibit morphological defects of the head and tail, premature chromosomal condensation, and nuclear damage. However, the molecular functions of SEPT12 during spermatogenesis remain unclear. To determine the molecular functions of SEPT12, we applied a yeast 2-hybrid system to identify SEPT12 interactors. Seven proteins that interact with SEPT12 were identified: SEPT family proteins (SEPT4 and SEPT6, nuclear or nuclear membrane proteins (protamine 2, sperm-associated antigen 4, and NDC1 transmembrane nucleoproine, and sperm-related structural proteins (pericentriolar material 1 and obscurin-like 1. Sperm-associated antigen 4 (SPAG4; also known as SUN4 belongs to the SUN family of proteins and acts as a linker protein between nucleoskeleton and cytoskeleton proteins and localizes in the nuclear membrane. We determined that SEPT12 interacts with SPAG4 in a male germ cell line through coimmunoprecipitation. During human spermiogenesis, SEPT12 is colocalized with SPAG4 near the nuclear periphery in round spermatids and in the centrosome region in elongating spermatids. Furthermore, we observed that SEPT12/SPAG4/LAMINB1 formed complexes and were coexpressed in the nuclear periphery of round spermatids. In addition, mutated SEPT12, which was screened from an infertile man, affected the integration of these nuclear envelope complexes through coimmunoprecipitation. This was the first study that suggested that SEPT

  15. The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope

    Energy Technology Data Exchange (ETDEWEB)

    Kind, Barbara, E-mail: barbara.kind@uniklinikum-dresden.de [Children' s Hospital, Technical University Dresden, D-01307 Dresden (Germany); Koehler, Katrin, E-mail: katrin.koehler@uniklinikum-dresden.de [Children' s Hospital, Technical University Dresden, D-01307 Dresden (Germany); Lorenz, Mike, E-mail: mlorenz@mpi-cbg.de [Max Planck Institute of Molecular Cell Biology and Genetics, D-01307 Dresden (Germany); Huebner, Angela, E-mail: angela.huebner@uniklinikum-dresden.de [Children' s Hospital, Technical University Dresden, D-01307 Dresden (Germany)

    2009-12-11

    The nuclear pore complex (NPC) consists of {approx}30 different proteins and provides the only sites for macromolecular transport between cytoplasm and nucleus. ALADIN was discovered as a new member of the NPC. Mutations in ALADIN are known to cause triple A syndrome, a rare autosomal recessive disorder characterized by adrenal insufficiency, alacrima, and achalasia. The function and exact location of the nucleoporin ALADIN within the NPC multiprotein complex is still unclear. Using a siRNA-based approach we downregulated the three known membrane integrated nucleoporins NDC1, GP210, and POM121 in stably expressing GFP-ALADIN HeLa cells. We identified NDC1 but not GP210 and POM121 as the main anchor of ALADIN within the NPC. Solely the depletion of NDC1 caused mislocalization of ALADIN. Vice versa, the depletion of ALADIN led also to disappearance of NDC1 at the NPC. However, the downregulation of two further membrane-integral nucleoporins GP210 and POM121 had no effect on ALADIN localization. Furthermore, we could show a direct association of NDC1 and ALADIN in NPCs by fluorescence resonance energy transfer (FRET) measurements. Based on our findings we conclude that ALADIN is anchored in the nuclear envelope via NDC1 and that this interaction gets lost, if ALADIN is mutated. The loss of integration of ALADIN in the NPC is a main pathogenetic aspect for the development of the triple A syndrome and suggests that the interaction between ALADIN and NDC1 may be involved in the pathogenesis of the disease.

  16. Cervical Chondrocutaneous Branchial Remnants.

    Science.gov (United States)

    Klockars, Tuomas; Kajosaari, Lauri

    2017-03-01

      Cervical chondrocutaneous branchial remnants are rare malformations usually found in the lower neck. As high as 76% of patients have been reported to have associated anomalies. We review the literature and report a case series of seven patients with cervical cartilaginous remnants.   A retrospective case series of seven patients identified from the electronic hospital records.   Seven patients with cervical chondrocutaneous branchial remnants were identified (six boys and one girl). Only one of the patients had associated anomalies.   A review of the literature revealed no evidence for sinuses or cysts related to cervical chondrocutaneous branchial remnants. Operative treatment can be postponed to a suitable and safe age. There is marked variation in the reported prevalence of associated anomalies, ranging from 11% to 76%.

  17. Nuclear Envelope Phosphatase 1-Regulatory Subunit 1 (Formerly TMEM188) Is the Metazoan Spo7p Ortholog and Functions in the Lipin Activation Pathway*

    Science.gov (United States)

    Han, Sungwon; Bahmanyar, Shirin; Zhang, Peixiang; Grishin, Nick; Oegema, Karen; Crooke, Roseann; Graham, Mark; Reue, Karen; Dixon, Jack E.; Goodman, Joel M.

    2012-01-01

    Lipin-1 catalyzes the formation of diacylglycerol from phosphatidic acid. Lipin-1 mutations cause lipodystrophy in mice and acute myopathy in humans. It is heavily phosphorylated, and the yeast ortholog Pah1p becomes membrane-associated and active upon dephosphorylation by the Nem1p-Spo7p membrane complex. A mammalian ortholog of Nem1p is the C-terminal domain nuclear envelope phosphatase 1 (CTDNEP1, formerly “dullard”), but its Spo7p-like partner is unknown, and the need for its existence is debated. Here, we identify the metazoan ortholog of Spo7p, TMEM188, renamed nuclear envelope phosphatase 1-regulatory subunit 1 (NEP1-R1). CTDNEP1 and NEP1-R1 together complement a nem1Δspo7Δ strain to block endoplasmic reticulum proliferation and restore triacylglycerol levels and lipid droplet number. The two human orthologs are in a complex in cells, and the amount of CTDNEP1 is increased in the presence of NEP1-R1. In the Caenorhabditis elegans embryo, expression of nematode CTDNEP1 and NEP1-R1, as well as lipin-1, is required for normal nuclear membrane breakdown after zygote formation. The expression pattern of NEP1-R1 and CTDNEP1 in human and mouse tissues closely mirrors that of lipin-1. CTDNEP1 can dephosphorylate lipins-1a, -1b, and -2 in human cells only in the presence of NEP1-R1. The nuclear fraction of lipin-1b is increased when CTDNEP1 and NEP1-R1 are co-expressed. Therefore, NEP1-R1 is functionally conserved from yeast to humans and functions in the lipin activation pathway. PMID:22134922

  18. A-type and B-type lamins initiate layer assembly at distinct areas of the nuclear envelope in living cells

    Energy Technology Data Exchange (ETDEWEB)

    Furukawa, Kazuhiro, E-mail: furukawa@chem.sc.niigata-u.ac.jp [Department of Chemistry, Faculty of Science, Niigata University, Niigata 950-2181 (Japan); Ishida, Kazuya; Tsunoyama, Taka-aki; Toda, Suguru; Osoda, Shinichi; Horigome, Tsuneyoshi [Department of Chemistry, Faculty of Science, Niigata University, Niigata 950-2181 (Japan); Fisher, Paul A. [Department of Pharmacological Sciences, School of Medicine, University Medical Center, State University of New York at Stony Brook, Stony Brook, NY 11794-8651 (United States); Sugiyama, Shin [Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464-8602 (Japan)

    2009-04-15

    To investigate nuclear lamina re-assembly in vivo, Drosophila A-type and B-type lamins were artificially expressed in Drosophila lamin Dm{sub 0}null mutant brain cells. Both exogenous lamin C (A-type) and Dm{sub 0} (B-type) formed sub-layers at the nuclear periphery, and efficiently reverted the abnormal clustering of the NPC. Lamin C initially appeared where NPCs were clustered, and subsequently extended along the nuclear periphery accompanied by the recovery of the regular distribution of NPCs. In contrast, lamin Dm{sub 0} did not show association with the clustered NPCs during lamina formation and NPC spacing recovered only after completion of a closed lamin Dm{sub 0} layer. Further, when lamin Dm{sub 0} and C were both expressed, they did not co-polymerize, initiating layer formation in separate regions. Thus, A and B-type lamins reveal differing properties during lamina assembly, with A-type having the primary role in organizing NPC distribution. This previously unknown complexity in the assembly of the nuclear lamina could be the basis for intricate nuclear envelope functions.

  19. Evolution of Supernova Remnants

    Science.gov (United States)

    Arbutina, B.

    2017-12-01

    This book, both a monograph and a graduate textbook, is based on my original research and partly on the materials prepared earlier for the 2007 and 2008 IARS Astrophysics Summer School in Istanbul, AstroMundus course 'Supernovae and Their Remnants' that was held for the first time in 2011 at the Department of Astronomy, Faculty of Mathematics, University of Belgrade, and a graduate course 'Evolution of Supernova Remnants' that I teach at the aforementioned university. The first part Supernovae (introduction, thermonuclear supernovae, core-collapse supernovae) provides introductory information and explains the classification and physics of supernova explosions, while the second part Supernova remnants (introduction, shock waves, cosmic rays and particle acceleration, magnetic fields, synchrotron radiation, hydrodynamic and radio evolution of supernova remnants), which is the field I work in, is more detailed in scope i.e. technical/mathematical. Special attention is paid to details of mathematical derivations that often cannot be found in original works or available literature. Therefore, I believe it can be useful to both, graduate students and researchers interested in the field.

  20. Nuclear envelope-distributed CD147 interacts with and inhibits the transcriptional function of RING1 and promotes melanoma cell motility.

    Directory of Open Access Journals (Sweden)

    Junchen Chen

    Full Text Available Melanoma accounts for nearly 80% of all deaths associated with skin cancer.CD147 plays a very important role in melanoma progression and the expression level may correlate with tumor malignancy. RING1 can bind DNA and act as a transcriptional repressor, play an important role in the aggressive phenotype in melanoma. The interactions between CD147 and RING1 were identified with a yeast two-hybrid and RING1 interacted with CD147 through the transmembrane domain. RING1 inhibits CD147's capability promoting melanoma cell migration. In conclusion, the study identified novel interactions between CD147 and RING1, recovered CD147 nuclear envelope distribution in melanoma cells, and suggested a new mechanism underlying how cytoplasmic CD147 promotes melanoma development.

  1. Nuclear envelope-distributed CD147 interacts with and inhibits the transcriptional function of RING1 and promotes melanoma cell motility.

    Science.gov (United States)

    Chen, Junchen; Peng, Cong; Lei, Li; Zhang, Jianglin; Zeng, Weiqi; Chen, Xiang

    2017-01-01

    Melanoma accounts for nearly 80% of all deaths associated with skin cancer.CD147 plays a very important role in melanoma progression and the expression level may correlate with tumor malignancy. RING1 can bind DNA and act as a transcriptional repressor, play an important role in the aggressive phenotype in melanoma. The interactions between CD147 and RING1 were identified with a yeast two-hybrid and RING1 interacted with CD147 through the transmembrane domain. RING1 inhibits CD147's capability promoting melanoma cell migration. In conclusion, the study identified novel interactions between CD147 and RING1, recovered CD147 nuclear envelope distribution in melanoma cells, and suggested a new mechanism underlying how cytoplasmic CD147 promotes melanoma development.

  2. Cell cycle regulation of human immunodeficiency virus type 1 integration in T cells: antagonistic effects of nuclear envelope breakdown and chromatin condensation

    International Nuclear Information System (INIS)

    Mannioui, Abdelkrim; Schiffer, Cecile; Felix, Nathalie

    2004-01-01

    We examined the influence of mitosis on the kinetics of human immunodeficiency virus type 1 integration in T cells. Single-round infection of cells arrested in G1b or allowed to synchronously proceed through division showed that mitosis delays virus integration until 18-24 h postinfection, whereas integration reaches maximum levels by 15 h in G1b-arrested cells. Subcellular fractionation of metaphase-arrested cells indicated that, while nuclear envelope disassembly facilitates docking of viral DNA to chromatin, chromosome condensation directly antagonizes and therefore delays integration. As a result of the balance between the two effects, virus integration efficiency is eventually up to threefold greater in dividing cells. At the single-cell level, using a green fluorescent protein-expressing reporter virus, we found that passage through mitosis leads to prominent asymmetric segregation of the viral genome in daughter cells without interfering with provirus expression

  3. The Use of Two-Photon FRET-FLIM to Study Protein Interactions During Nuclear Envelope Fusion In Vivo and In Vitro.

    Science.gov (United States)

    Byrne, Richard D; Larijani, Banafshé; Poccia, Dominic L

    2016-01-01

    FRET-FLIM techniques have wide application in the study of protein and protein-lipid interactions in cells. We have pioneered an imaging platform for accurate detection of functional states of proteins and their interactions in fixed cells. This platform, two-site-amplified Förster resonance energy transfer (a-FRET), allows greater signal generation while retaining minimal noise thus enabling application of fluorescence lifetime imaging microscopy (FLIM) to be routinely deployed in different types of cells and tissue. We have used the method described here, time-resolved FRET monitored by two-photon FLIM, to demonstrate the direct interaction of Phospholipase Cγ (PLCγ) by Src Family Kinase 1 (SFK1) during nuclear envelope formation and during male and female pronuclear membrane fusion in fertilized sea urchin eggs. We describe here a generic method that can be applied to monitor any proteins of interest.

  4. PROGENITORS OF RECOMBINING SUPERNOVA REMNANTS

    Energy Technology Data Exchange (ETDEWEB)

    Moriya, Takashi J., E-mail: takashi.moriya@ipmu.jp [Kavli Institute for the Physics and Mathematics of the Universe, Todai Institutes for Advanced Study, University of Tokyo, Kashiwanoha 5-1-5, Kashiwa, Chiba 277-8583 (Japan)

    2012-05-01

    Usual supernova remnants have either ionizing plasma or plasma in collisional ionization equilibrium, i.e., the ionization temperature is lower than or equal to the electron temperature. However, the existence of recombining supernova remnants, i.e., supernova remnants with ionization temperature higher than the electron temperature, has been recently confirmed. One suggested way to have recombining plasma in a supernova remnant is to have a dense circumstellar medium at the time of the supernova explosion. If the circumstellar medium is dense enough, collisional ionization equilibrium can be established in the early stage of the evolution of the supernova remnant and subsequent adiabatic cooling, which occurs after the shock wave gets out of the dense circumstellar medium, makes the electron temperature lower than the ionization temperature. We study the circumstellar medium around several supernova progenitors and show which supernova progenitors can have a circumstellar medium dense enough to establish collisional ionization equilibrium soon after the explosion. We find that the circumstellar medium around red supergiants (especially massive ones) and the circumstellar medium dense enough to make Type IIn supernovae can establish collisional ionization equilibrium soon after the explosion and can evolve to become recombining supernova remnants. Wolf-Rayet stars and white dwarfs have the possibility to be recombining supernova remnants but the fraction is expected to be very small. As the occurrence rate of the explosions of red supergiants is much higher than that of Type IIn supernovae, the major progenitors of recombining supernova remnants are likely to be red supergiants.

  5. The function of the inner nuclear envelope protein SUN1 in mRNA export is regulated by phosphorylation.

    Science.gov (United States)

    Li, Ping; Stumpf, Maria; Müller, Rolf; Eichinger, Ludwig; Glöckner, Gernot; Noegel, Angelika A

    2017-08-22

    SUN1, a component of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, functions in mammalian mRNA export through the NXF1-dependent pathway. It associates with mRNP complexes by direct interaction with NXF1. It also binds to the NPC through association with the nuclear pore component Nup153, which is involved in mRNA export. The SUN1-NXF1 association is at least partly regulated by a protein kinase C (PKC) which phosphorylates serine 113 (S113) in the N-terminal domain leading to reduced interaction. The phosphorylation appears to be important for the SUN1 function in nuclear mRNA export since GFP-SUN1 carrying a S113A mutation was less efficient in restoring mRNA export after SUN1 knockdown as compared to the wild type protein. By contrast, GFP-SUN1-S113D resembling the phosphorylated state allowed very efficient export of poly(A)+RNA. Furthermore, probing a possible role of the LINC complex component Nesprin-2 in this process we observed impaired mRNA export in Nesprin-2 knockdown cells. This effect might be independent of SUN1 as expression of a GFP tagged SUN-domain deficient SUN1, which no longer can interact with Nesprin-2, did not affect mRNA export.

  6. AFM visualization of sub-50nm polyplex disposition to the nuclear pore complex without compromising the integrity of the nuclear envelope

    DEFF Research Database (Denmark)

    Andersen, Helene; Parhamifar, Ladan; Hunter, A Christy

    2016-01-01

    that were microinjected into the oocytes of Xenopus laevis, as an example of a non-dividing cell, is exclusive to the nuclear pore complex (NPC). AFM images show NPCs clogged only with sub-50nm polyplexes. This mode of disposition neither altered the morphology/integrity of the nuclear membrane nor the NPC...

  7. Meiosis, egg activation, and nuclear envelope breakdown are differentially reliant on Ca2+, whereas germinal vesicle breakdown is Ca2+ independent in the mouse oocyte

    Science.gov (United States)

    Tombes, R. M.; Simerly, C.; Borisy, G. G.; Schatten, G.

    1992-01-01

    During early development, intracellular Ca2+ mobilization is not only essential for fertilization, but has also been implicated during other meiotic and mitotic events, such as germinal vesicle breakdown (GVBD) and nuclear envelope breakdown (NEBD). In this study, the roles of intracellular and extracellular Ca2+ were examined during meiotic maturation and reinitiation at parthenogenetic activation and during first mitosis in a single species using the same methodologies. Cumulus-free metaphase II mouse oocytes immediately resumed anaphase upon the induction of a large, transient Ca2+ elevation. This resumption of meiosis and associated events, such as cortical granule discharge, were not sensitive to extracellular Ca2+ removal, but were blocked by intracellular Ca2+ chelators. In contrast, meiosis I was dependent on external Ca2+; in its absence, the formation and function of the first meiotic spindle was delayed, the first polar body did not form and an interphase-like state was induced. GVBD was not dependent on external Ca2+ and showed no associated Ca2+ changes. NEBD at first mitosis in fertilized eggs, on the other hand, was frequently, but not always associated with a brief Ca2+ transient and was dependent on Ca2+ mobilization. We conclude that GVBD is Ca2+ independent, but that the dependence of NEBD on Ca2+ suggests regulation by more than one pathway. As cells develop from Ca(2+)-independent germinal vesicle oocytes to internal Ca(2+)-dependent pronuclear eggs, internal Ca2+ pools increase by approximately fourfold.

  8. Application of FMEA-DEA (Failure Modes and Effect Analysis - Data Envelopment Analysis) to the air conditioning system of the control room a nuclear power plant

    International Nuclear Information System (INIS)

    Barbosa Junior, Gilberto Varanda

    2007-03-01

    This dissertation presents the FMEA-DEA analysis application to the air conditioning system of the control room of a nuclear power plant. After obtaining the failure modes, the index associated to the occurrence probability, the severity of the effects and the potential of detention, a priority order is established for the failure modes or deviations. This number is obtained by multiplying the three mentioned index that vary in a natural scale from 1 to 10, where the higher the index, the more critical the situation will be. In this work, it is intended to use a model based on the data envelopment analysis, DEA jointly with the FMEA, to identify the current efficiency of the system and which failure modes or deviations are considered more critical, and by means of the weights attributed for the mathematical modeling to identify which index are contributing more for these deviations. From this identification, improvements can be set, which may consider administrative changes, operator training and so on, thus adding value to the final product. (author)

  9. Enveloping Aerodynamic Decelerator

    Science.gov (United States)

    Nock, Kerry T. (Inventor); Aaron, Kim M. (Inventor); McRonald, Angus D. (Inventor); Gates, Kristin L. (Inventor)

    2018-01-01

    An inflatable aerodynamic deceleration method and system is provided for use with an atmospheric entry payload. The inflatable aerodynamic decelerator includes an inflatable envelope and an inflatant, wherein the inflatant is configured to fill the inflatable envelope to an inflated state such that the inflatable envelope surrounds the atmospheric entry payload, causing aerodynamic forces to decelerate the atmospheric entry payload.

  10. Transfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factor.

    Science.gov (United States)

    Goujon, Caroline; Moncorgé, Olivier; Bauby, Hélène; Doyle, Tomas; Barclay, Wendy S; Malim, Michael H

    2014-08-01

    The myxovirus resistance 2 (MX2) protein of humans has been identified recently as an interferon (IFN)-inducible inhibitor of human immunodeficiency virus type 1 (HIV-1) that acts at a late postentry step of infection to prevent the nuclear accumulation of viral cDNA (C. Goujon et al., Nature 502:559-562, 2013, http://dx.doi.org/10.1038/nature12542; M. Kane et al., Nature 502:563-566, 2013, http://dx.doi.org/10.1038/nature12653; Z. Liu et al., Cell Host Microbe 14:398-410, 2013, http://dx.doi.org/10.1016/j.chom.2013.08.015). In contrast, the closely related human MX1 protein, which suppresses infection by a range of RNA and DNA viruses (such as influenza A virus [FluAV]), is ineffective against HIV-1. Using a panel of engineered chimeric MX1/2 proteins, we demonstrate that the amino-terminal 91-amino-acid domain of MX2 confers full anti-HIV-1 function when transferred to the amino terminus of MX1, and that this fusion protein retains full anti-FluAV activity. Confocal microscopy experiments further show that this MX1/2 fusion, similar to MX2 but not MX1, can localize to the nuclear envelope (NE), linking HIV-1 inhibition with MX accumulation at the NE. MX proteins are dynamin-like GTPases, and while MX1 antiviral function requires GTPase activity, neither MX2 nor MX1/2 chimeras require this attribute to inhibit HIV-1. This key discrepancy between the characteristics of MX1- and MX2-mediated viral resistance, together with previous observations showing that the L4 loop of the stalk domain of MX1 is a critical determinant of viral substrate specificity, presumably reflect fundamental differences in the mechanisms of antiviral suppression. Accordingly, we propose that further comparative studies of MX proteins will help illuminate the molecular basis and subcellular localization requirements for implementing the noted diversity of virus inhibition by MX proteins. Interferon (IFN) elicits an antiviral state in cells through the induction of hundreds of IFN

  11. Remnants of Lost Geology

    Science.gov (United States)

    2003-01-01

    [figure removed for brevity, see original site] In eastern Arabia Terra, remnants of a once vast layered terrain are evident as isolated buttes, mesas, and deeply-filled craters. The origin of the presumed sediments that created the layers is unknown, but those same sediments, now eroded, may be the source of the thick mantle of dust that covers much of Arabia Terra today.Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time.NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen at Arizona State University. Lockheed Martin Astronautics, Denver, is the prime contractor for the Odyssey project, and developed and built the orbiter. Mission operations are conducted jointly from Lockheed Martin and from JPL, a division of the California Institute of Technology in Pasadena.Image information: VIS instrument. Latitude 20.5, Longitude 50 East (310 West). 19 meter/pixel resolution.

  12. Binding of two desmin derivatives to the plasma membrane and the nuclear envelope of avian erythrocytes: evidence for a conserved site-specificity in intermediate filament-membrane interactions

    International Nuclear Information System (INIS)

    Georgatos, S.D.; Weber, K.; Geisler, N.; Blobel, G.

    1987-01-01

    Using solution binding assays, the authors found that a 45-kDa fragment of 125 I-labelled desmin, lacking 67 residues from the N terminus, could specifically associate with avian erythrocyte nuclear envelopes but not with plasma membranes from the same cells. It was also observed that a 50-kDa desmin peptide, missing 27 C-terminal residues, retained the ability to bind to both membrane preparations. Displacement experiments with an excess of purified vimentin suggested that the two desmin derivatives were interacting with a previously identified vimentin receptor at the nuclear envelope, the protein lamin B. Additional analysis by affinity chromatography confirmed this conclusion. Employing an overlay assay, they demonstrated that the 50-kDa fragment, but not the 45-kDa desmin peptide, was capable of interacting with the plasma membrane polypeptide ankyrin (a known vimentin attachment site), as was intact vimentin. Conversely, the nuclear envelope protein lamin B was recognized by both fragments but not by a chymotryptic peptide composed solely of the helical rod domain of desmin. These data imply that the lamin B-binding site on desmin resides within the 21 residues following its helical rod domain, whereas the ankyrin-associating region is localized within its N-terminal head domain, exactly as in the case of vimentin

  13. Postprandial Hyperlipidemia and Remnant Lipoproteins.

    Science.gov (United States)

    Masuda, Daisaku; Yamashita, Shizuya

    2017-02-01

    Fasting hypertriglyceridemia is positively associated with the morbidity of coronary heart disease (CHD), and postprandial (non-fasting) hypertriglyceridemia is also correlated with the risk status for CHD, which is related to the increase in chylomicron (CM) remnant lipoproteins produced from the intestine. CM remnant particles, as well as oxidized low density lipoprotein (LDL) or very low density lipoprotein (VLDL) remnants, are highly atherogenic and act by enhancing systemic inflammation, platelet activation, coagulation, thrombus formation, and macrophage foam cell formation. The cholesterol levels of remnant lipoproteins significantly correlate with small, dense LDL; impaired glucose tolerance (IGT) and CHD prevalence. We have developed an assay of apolipoprotein (apo)B-48 levels to evaluate the accumulation of CM remnants. Fasting apoB-48 levels correlate with the morbidity of postprandial hypertriglyceridemia, obesity, type III hyperlipoproteinemia, the metabolic syndrome, hypothyroidism, chronic kidney disease, and IGT. Fasting apoB-48 levels also correlate with carotid intima-media thickening and CHD prevalence, and a high apoB-48 level is a significant predictor of CHD risk, independent of the fasting TG level. Diet interventions, such as dietary fibers, polyphenols, medium-chain fatty acids, diacylglycerol, and long-chain n-3 polyunsaturated fatty acids (PUFA), ameliorate postprandial hypertriglyceridemia, moreover, drugs for dyslipidemia (n-3 PUFA, statins, fibrates or ezetimibe) and diabetes concerning incretins (dipeptidyl-peptidase IV inhibitor or glucagon like peptide-1 analogue) may improve postprandial hypertriglyceridemia. Since the accumulation of CM remnants correlates to impaired lipid and glucose metabolism and atherosclerotic cardiovascular events, further studies are required to investigate the characteristics, physiological activities, and functions of CM remnants for the development of new interventions to reduce atherogenicity.

  14. Mechanism of protein import across the chloroplast envelope.

    Science.gov (United States)

    Chen, K; Chen, X; Schnell, D J

    2000-01-01

    The development and maintenance of chloroplasts relies on the contribution of protein subunits from both plastid and nuclear genomes. Most chloroplast proteins are encoded by nuclear genes and are post-translationally imported into the organelle across the double membrane of the chloroplast envelope. Protein import into the chloroplast consists of two essential elements: the specific recognition of the targeting signals (transit sequences) of cytoplasmic preproteins by receptors at the outer envelope membrane and the subsequent translocation of preproteins simultaneously across the double membrane of the envelope. These processes are mediated via the co-ordinate action of protein translocon complexes in the outer (Toc apparatus) and inner (Tic apparatus) envelope membranes.

  15. Storage envelopes or sleeves

    International Nuclear Information System (INIS)

    Freshwater, J.R.; Wagman, P.I.

    1980-01-01

    A storage envelope or sleeve particularly for processed X-ray films is described. It consists of front and back panels joined together at a hinge line and connected along the intermediate sides by connecting flaps. An inner pocket is formed from a third flap which is folded to lie against the inner face of the back panel. The panels may have additional score lines parallel to the closed sides of the envelope and the inner pocket so that the envelope and the inner pocket can accommodate bulky contents. The free edge of the pocket is inset from the open side of the envelope, and finger cut-outs may be provided to facilitate access to the contents of the envelope and the pocket. (author)

  16. The prevalence of embryonic remnants following the recovery of post-hatching bovine embryos produced in vitro or by somatic cell nuclear transfer.

    Science.gov (United States)

    Alexopoulos, Natalie I; French, Andrew J

    2009-08-01

    The reliable collection of peri-implantation embryos in the bovine has important ramifications to post-transfer consequences, particularly in the elucidation of mechanisms associated with post-hatching embryo development and to perturbations in developmental growth following transfer. This study analyzed both in vitro produced (IVP) and somatic cell nuclear transfer (SCNT) embryo-like structures (ELS) recovered at Day (D) 14 and D21. The recovered ELS were subsequently processed for histological examination. At D14 and D21, many of the embryos recovered in the IVP group conformed to the appropriate stage of development. However, a significant number of anomalies were present in the SCNT groups when examined in more detail. Histological examination revealed that irrespective of whether these embryos had undergone trophoblast expansion to an ovoid, tubular or filamentous morphology, many had a degenerated hypoblast layer and a large proportion did not possess an epiblast and therefore could not differentiate into any of the three germ layers as would be expected at the neural groove or somite stage. The prevalence of this developmental pattern was random and did not correlate with treatment (IVP or SCNT) or with types of structures recovered. The rapid embryo elongation period also coincides with the time of greatest embryonic loss and these observations could have important implications for assessing the recovery of embryos post-transfer where incorrect morphological assessment could lead to false implantation and pregnancy determination rates. The implementation of additional methodology is required to adequately characterize the quality of IVP and SCNT-derived embryos collected post-transfer.

  17. Protective plasma envelope

    International Nuclear Information System (INIS)

    Bocharov, V.N.; Konstantinov, S.G.; Kudryavtsev, A.M.; Myskin, O.K.; Panasyuk, V.M.; Tsel'nik, F.A.

    1984-06-01

    A method of creating an annular plasma envelope used to protect the hot plasma from flows of impurities and gases from the walls of the vacuum chamber is described. The diameter of the envelope is 30 cm, the thickness of the wall is 1.5 cm, the length is 2.5 m, and its density is from 10 13 to 10 14 cm -3 . The envelope attenuates the incident (from outside) flow of helium 10-fold and the low of hydrogen 20-fold

  18. Einstein Observations of Galactic supernova remnants

    Science.gov (United States)

    Seward, Frederick D.

    1990-01-01

    This paper summarizes the observations of Galactic supernova remnants with the imaging detectors of the Einstein Observatory. X-ray surface brightness contours of 47 remnants are shown together with gray-scale pictures. Count rates for these remnants have been derived and are listed for the HRI, IPC, and MPC detectors.

  19. HI Absorption in Merger Remnants

    Science.gov (United States)

    Teng, Stacy H.; Veileux, Sylvain; Baker, Andrew J.

    2012-01-01

    It has been proposed that ultraluminous infrared galaxies (ULIRGs) pass through a luminous starburst phase, followed by a dust-enshrouded AGN phase, and finally evolve into optically bright "naked" quasars once they shed their gas/dust reservoirs through powerful wind events. We present the results of our recent 21- cm HI survey of 21 merger remnants with the Green Bank Telescope. These remnants were selected from the QUEST (Quasar/ULIRG Evolution Study) sample of ULIRGs and PG quasars; our targets are all bolometrically dominated by AGN and sample all phases of the proposed ULIRG -> IR-excess quasar -> optical quasar sequence. We explore whether there is an evolutionary connection between ULIRGs and quasars by looking for the occurrence of HI absorption tracing neutral gas outflows; our results will allow us to identify where along the sequence the majority of a merger's gas reservoir is expelled.

  20. Molecular clouds near supernova remnants

    International Nuclear Information System (INIS)

    Wootten, H.A.

    1978-01-01

    The physical properties of molecular clouds near supernova remnants were investigated. Various properties of the structure and kinematics of these clouds are used to establish their physical association with well-known remmnants. An infrared survey of the most massive clouds revealed embedded objects, probably stars whose formation was induced by the supernova blast wave. In order to understand the relationship between these and other molecular clouds, a control group of clouds was also observed. Excitation models for dense regions of all the clouds are constructed to evaluate molecular abundances in these regions. Those clouds that have embedded stars have lower molecular abundances than the clouds that do not. A cloud near the W28 supernova remnant also has low abundances. Molecular abundances are used to measure an important parameter, the electron density, which is not directly observable. In some clouds extensive deuterium fractionation is observed which confirms electron density measurements in those clouds. Where large deuterium fractionation is observed, the ionization rate in the cloud interior can also be measured. The electron density and ionization rate in the cloud near W28 are higher than in most clouds. The molecular abundances and electron densities are functions of the chemical and dynamical state of evolution of the cloud. Those clouds with lowest abundances are probably the youngest clouds. As low-abundance clouds, some clouds near supernova remnants may have been recently swept from the local interstellar material. Supernova remnants provide sites for star formation in ambient clouds by compressing them, and they sweep new clouds from more diffuse local matter

  1. SAFEGUARDS ENVELOPE: PREVIOUS WORK AND EXAMPLES

    International Nuclear Information System (INIS)

    Metcalf, Richard; Bevill, Aaron; Charlton, William; Bean, Robert

    2008-01-01

    The future expansion of nuclear power will require not just electricity production but fuel cycle facilities such as fuel fabrication and reprocessing plants. As large reprocessing facilities are built in various states, they must be built and operated in a manner to minimize the risk of nuclear proliferation. Process monitoring has returned to the spotlight as an added measure that can increase confidence in the safeguards of special nuclear material (SNM). Process monitoring can be demonstrated to lengthen the allowable inventory period by reducing accountancy requirements, and to reduce the false positive indications. The next logical step is the creation of a Safeguards Envelope, a set of operational parameters and models to maximize anomaly detection and inventory period by process monitoring while minimizing operator impact and false positive rates. A brief example of a rudimentary Safeguards Envelope is presented, and shown to detect synthetic diversions overlaying a measured processing plant data set. This demonstration Safeguards Envelope is shown to increase the confidence that no SNM has been diverted with minimal operator impact, even though it is based on an information sparse environment. While the foundation on which a full Safeguards Envelope can be built has been presented in historical demonstrations of process monitoring, several requirements remain yet unfulfilled. Future work will require reprocessing plant transient models, inclusion of 'non-traditional' operating data, and exploration of new methods of identifying subtle events in transient processes

  2. Safeguards Envelope Progress FY10

    International Nuclear Information System (INIS)

    Metcalf, Richard

    2010-01-01

    The Safeguards Envelope is a strategy to determine a set of specific operating parameters within which nuclear facilities may operate to maximize safeguards effectiveness without sacrificing safety or plant efficiency. This paper details the additions to the advanced operating techniques that will be applied to real plant process monitoring (PM) data from the Idaho Chemical Processing Plant (ICPP). Research this year focused on combining disparate pieces of data together to maximize operating time with minimal downtime due to safeguards. A Chi-Square and Croiser's cumulative sum were both included as part of the new analysis. Because of a major issue with the original data, the implementation of the two new tests did not add to the existing set of tests, though limited one-variable optimization made a small increase in detection probability. Additional analysis was performed to determine if prior analysis would have caused a major security or safety operating envelope issue. It was determined that a safety issue would have resulted from the prior research, but that the security may have been increased under certain conditions.

  3. Remnant cholesterol and ischemic heart disease

    DEFF Research Database (Denmark)

    Varbo, Anette; Nordestgaard, Børge G

    2014-01-01

    PURPOSE OF REVIEW: To review recent advances in the field of remnant cholesterol as a contributor to the development of ischemic heart disease (IHD). RECENT FINDINGS: Epidemiologic, mechanistic, and genetic studies all support a role for elevated remnant cholesterol (=cholesterol in triglyceride......-rich lipoproteins) as a contributor to the development of atherosclerosis and IHD. Observational studies show association between elevated remnant cholesterol and IHD, and mechanistic studies show remnant cholesterol accumulation in the arterial wall like LDL-cholesterol (LDL-C) accumulation. Furthermore, large...... genetic studies show evidence of remnant cholesterol as a causal risk factor for IHD independent of HDL-cholesterol levels. Genetic studies also show that elevated remnant cholesterol is associated with low-grade inflammation, whereas elevated LDL-C is not. There are several pharmacologic ways of lowering...

  4. HIV-1 envelope glycoprotein

    Science.gov (United States)

    Caulfield, Michael; Cupo, Albert; Dean, Hansi; Hoffenberg, Simon; King, C. Richter; Klasse, P. J.; Marozsan, Andre; Moore, John P.; Sanders, Rogier W.; Ward, Andrew; Wilson, Ian; Julien, Jean-Philippe

    2017-08-22

    The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization, electron microscopy and other biophysical, biochemical and immunological studies for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions, which are formulated into the vaccines of the present invention.

  5. Common envelope evolution

    NARCIS (Netherlands)

    Taam, Ronald E.; Ricker, Paul M.

    2010-01-01

    The common envelope phase of binary star evolution plays a central role in many evolutionary pathways leading to the formation of compact objects in short period systems. Using three dimensional hydrodynamical computations, we review the major features of this evolutionary phase, focusing on the

  6. Neutron Stars in Supernova Remnants and Beyond

    Science.gov (United States)

    Gvaramadze, V. V.

    We discuss a concept of off-centred cavity supernova explosion as applied to neutron star/supernova remnant associations and show how this concept could be used to preclude the anti-humane decapitating the Duck (G5.4-1.2 + G5.27-0.9) and dismembering the Swan (Cygnus Loop), as well as to search for a stellar remnant associated with the supernova remnant RCW86.

  7. Neutron Stars in Supernova Remnants and Beyond

    OpenAIRE

    Gvaramadze, V. V.

    2002-01-01

    We discuss a concept of off-centred cavity supernova explosion as applied to neutron star/supernova remnant associations and show how this concept could be used to preclude the anti-humane decapitating the Duck (G5.4-1.2 + G5.27-0.9) and dismembering the Swan (Cygnus Loop), as well as to search for a stellar remnant associated with the supernova remnant RCW86.

  8. Supernova models with slow energy pumping and galactic supernova remnants

    International Nuclear Information System (INIS)

    Utrobin, V.P.

    1978-01-01

    The study of supernova (SN) models with slow energy pumping is continued. At maximum luminosity the main characteristics of a SN are shown to be independent of the initial structure of the model. However, they depend on the mass Msub(e) of the envelope, and on the intensity of energy pumping Lsub(epsilon), with an increase of Msub(e) leading qualitatively to the same changes in the SN parameters as a decrease in Lsub(epsilon). A simple relationship connecting the important SN parameters is obtained. From the inflection of the color index B-V curve, the possibility of deriving the characteristic time of energy pumping with intensity Lsub(epsilon) approximately 10 44 erg s -1 is pointed out. The comparison of the extragalactic type I SN observations with the results of calculations leads to the estimate of Msub(e) approximately 0.3-0.7 solar masses. An investigation of the galactic type I SN remnants is carried out. The estimate of Msub(e) approximately 0.2-0.3 solar masses is obtained for the remnants of supernovae SN 1006, SN 1572, and SN 1604. It completely fits the results for the extragalactic type I SNs. The total initial mass of SN 1604 presupernova was shown to be at least about 7 solar masses. It was established that the Crab nebula resulted from the outburst of a peculiar SN. The unique properties of such SNs, including SN 1054, are due to the low intensity of energy pumping (Lsub(epsilon) approximately 10 42 erg s -1 ). The mass of the envelope of the Crab nebula is evaluated to be Msub(e) approximately 0.7 solar masses. (Auth.)

  9. (Quasi-)Poisson enveloping algebras

    OpenAIRE

    Yang, Yan-Hong; Yao, Yuan; Ye, Yu

    2010-01-01

    We introduce the quasi-Poisson enveloping algebra and Poisson enveloping algebra for a non-commutative Poisson algebra. We prove that for a non-commutative Poisson algebra, the category of quasi-Poisson modules is equivalent to the category of left modules over its quasi-Poisson enveloping algebra, and the category of Poisson modules is equivalent to the category of left modules over its Poisson enveloping algebra.

  10. SUPERNOVA 1987A: A TEMPLATE TO LINK SUPERNOVAE TO THEIR REMNANTS

    Energy Technology Data Exchange (ETDEWEB)

    Orlando, S.; Miceli, M.; Pumo, M. L.; Bocchino, F., E-mail: orlando@astropa.inaf.it [INAF—Osservatorio Astronomico di Palermo “G.S. Vaiana”, Piazza del Parlamento 1, I-90134 Palermo (Italy)

    2015-09-10

    The emission of supernova remnants (SNRs) reflects the properties of both the progenitor supernovae (SNe) and the surrounding environment. The complex morphology of the remnants, however, hampers the disentanglement of the two contributions. Here, we aim at identifying the imprint of SN 1987A on the X-ray emission of its remnant and at constraining the structure of the environment surrounding the SN. We performed high-resolution hydrodynamic simulations describing SN 1987A soon after the core-collapse and the following three-dimensional expansion of its remnant between days 1 and 15,000 after the SN. We demonstrated that the physical model reproducing the main observables of SN 1987A during the first 250 days of evolution also reproduces the X-ray emission of the subsequent expanding remnant, thus bridging the gap between SNe and SNRs. By comparing model results with observations, we constrained the explosion energy in the range 1.2–1.4 × 10{sup 51} erg and the envelope mass in the range 15–17 M{sub ⊙}. We found that the shape of X-ray lightcurves and spectra at early epochs (<15 years) reflects the structure of outer ejecta: our model reproduces the observations if the outermost ejecta have a post-explosion radial profile of density approximated by a power law with index α = −8. At later epochs, the shapes of X-ray lightcurves and spectra reflect the density structure of the nebula around SN 1987A. This enabled us to ascertain the origin of the multi-thermal X-ray emission, disentangle the imprint of the SN on the remnant emission from the effects of the remnant interaction with the environment, and constrain the pre-supernova structure of the nebula.

  11. Thermal Activated Envelope

    DEFF Research Database (Denmark)

    Foged, Isak Worre; Pasold, Anke

    2015-01-01

    The research studies the making of a responsive architectural envelope based on bi-materials. The bi-materials are organized according to a method that combines different isotropic metals and plastic into an active composite structure that reacts to temperature variations. Through an evolutionary......, environmental dynamics and occupancy dynamics. Lastly, a physical prototype is created, which illustrates the physical expression of the bi-materials and the problems related to manufacturing of these composite structures.......The research studies the making of a responsive architectural envelope based on bi-materials. The bi-materials are organized according to a method that combines different isotropic metals and plastic into an active composite structure that reacts to temperature variations. Through an evolutionary...

  12. Dynamical study of merger remnants

    International Nuclear Information System (INIS)

    Lake, G.; Dressler, A.; ATandT Bell Labs., Murray Hill, NJ; Mount Wilson and Las Campanas Observatories, Pasadena, CA; Carnegie Institution of Washington, Washington, DC)

    1986-01-01

    The velocity dispersion of objects from the Arp and the Arp-Madore atlases that have characteristics of recently merged galaxies is measured. These data are used to test the hypothesis that the remnants become normal elliptical galaxies after the fireworks of recent star formation subside. Accurate velocity dispersions of objects dominated by Balmer lines in the blue were measured using the uncontaminated Ca triplet feature in the extreme red (8400-8700 A). No deviation from the velocity dispersion expected for elliptical galaxies of comparable luminosity, is found, e.g., these systems follow the usual L-sigma relation with no zero-point shift. For a few galaxies without Balmer contamination, stellar rotation velocities are determined. One slow, one moderate, and one fast rotator are found. 54 references

  13. Progenitor's Signatures in Type Ia Supernova Remnants

    NARCIS (Netherlands)

    Chiotellis, A.; Kosenko, D.; Schure, K.M.; Vink, J.

    2013-01-01

    The remnants of Type Ia supernovae (SNe Ia) can provide important clues about their progenitor histories. We discuss two well-observed supernova remnants (SNRs) that are believed to have resulted from SNe Ia, and use various tools to shed light on the possible progenitor histories. We find that

  14. Nuclear envelope alterations in fibroblasts from LGMD1B patients carrying nonsense Y259X heterozygous or homozygous mutation in lamin A/C gene.

    NARCIS (Netherlands)

    Muchir, A.; Engelen, B.G.M. van; Lammens, M.M.Y.; Mislow, J.M.; McNally, E.; Schwartz, K.; Bonne, G.

    2003-01-01

    Mutations in the LMNA gene encoding nuclear lamins A and C are responsible for seven inherited disorders affecting specific tissues. We have analyzed skin fibroblasts from a patient with type 1B limb-girdle muscular dystrophy and from her deceased newborn grandchild carrying, respectively, a

  15. Uncertain data envelopment analysis

    CERN Document Server

    Wen, Meilin

    2014-01-01

    This book is intended to present the milestones in the progression of uncertain Data envelopment analysis (DEA). Chapter 1 gives some basic introduction to uncertain theories, including probability theory, credibility theory, uncertainty theory and chance theory. Chapter 2 presents a comprehensive review and discussion of basic DEA models. The stochastic DEA is introduced in Chapter 3, in which the inputs and outputs are assumed to be random variables. To obtain the probability distribution of a random variable, a lot of samples are needed to apply the statistics inference approach. Chapter 4

  16. Hydrodynamic evolution of neutron star merger remnants

    Science.gov (United States)

    Liu, Men-Quan; Zhang, Jie

    2017-11-01

    Based on the special relativistic hydrodynamic equations and updated cooling function, we investigate the long-term evolution of neutron stars merger (NSM) remnants by a one-dimensional hydrodynamic code. Three NSM models from one soft equation of state, SFHo, and two stiff equations of state, DD2 and TM1, are used to compare their influences on the hydrodynamic evolution of remnants. We present the luminosity, mass and radius of remnants, as well as the velocity, temperature and density of shocks. For a typical interstellar medium (ISM) density with solar metallicity, we find that the NSM remnant from the SFHo model makes much more changes to ISM in terms of velocity, density and temperature distributions, compared with the case of DD2 and TM1 models. The maximal luminosity of the NSM remnant from the SFHo model is 3.4 × 1038 erg s-1, which is several times larger than that from DD2 and TM1 models. The NSM remnant from the SFHo model can maintain high luminosity (>1038 erg s-1) for 2.29 × 104 yr. Furthermore, the density and temperature of remnants at the maximal luminosity are not sensitive to the power of the original remnant. For the ISM with the solar metallicity and nH = 1 cm- 3, the density of the first shock ∼10-23 g cm-3 and the temperature ∼3 × 105 K in the maximal luminosity phase; The temperature of the first shock decreases and there is a thin 'dense' shell with density ∼10-21 g cm-3 after the maximal luminosity. These characteristics may be helpful for future observations of NSM remnants.

  17. Exclusion of mRNPs and ribosomal particles from a thin zone beneath the nuclear envelope revealed upon inhibition of transport

    International Nuclear Information System (INIS)

    Kylberg, Karin; Bjoerk, Petra; Fomproix, Nathalie; Ivarsson, Birgitta; Wieslander, Lars; Daneholt, Bertil

    2010-01-01

    We have studied the nucleocytoplasmic transport of a specific messenger RNP (mRNP) particle, named Balbiani ring (BR) granule, and ribosomal RNP (rRNP) particles in the salivary glands of the dipteran Chironomus tentans. The passage of the RNPs through the nuclear pore complex (NPC) was inhibited with the nucleoporin-binding wheat germ agglutinin, and the effects were examined by electron microscopy. BR mRNPs bound to the nuclear basket increased in number, while BR mRNPs translocating through the central channel decreased, suggesting that the initiation of translocation proper had been inhibited. The rRNPs accumulated heavily in nucleoplasm, while no or very few rRNPs were recorded within nuclear baskets. Thus, the transport of rRNPs had been blocked prior to the entry into the baskets. Remarkably, the rRNPs had been excluded both from baskets and the space in between the baskets. We propose that normally basket fibrils move freely and repel RNPs from the exclusion zone unless the particles have affinity for and bind to nucleoporins within the baskets.

  18. Density and energy of supernova remnants

    Energy Technology Data Exchange (ETDEWEB)

    Canto, J [Manchester Univ. (UK). Dept. of Astronomy

    1977-12-01

    The effects of an interstellar magnetic field on the gas flow behind a strong shock front are considered. The ambient density and energy of supernova remnants are estimated from the intensity ratio of sulphur lines I(6717)/I(6731). It is found that, on average, the ambient density around galactic supernova remnants is 4 cm/sup -3/. The total energy appears to be the same for all supernova remnants (to within a factor = approximately 5). A mean value of 4 10/sup 51/ erg is found.

  19. Remnants of strong tidal interactions

    International Nuclear Information System (INIS)

    Mcglynn, T.A.

    1990-01-01

    This paper examines the properties of stellar systems that have recently undergone a strong tidal shock, i.e., a shock which removes a significant fraction of the particles in the system, and where the shocked system has a much smaller mass than the producer of the tidal field. N-body calculations of King models shocked in a variety of ways are performed, and the consequences of the shocks are investigated. The results confirm the prediction of Jaffe for shocked systems. Several models are also run where the tidal forces on the system are constant, simulating a circular orbit around a primary, and the development of tidal radii under these static conditions appears to be a mild process which does not dramatically affect material that is not stripped. The tidal radii are about twice as large as classical formulas would predict. Remnant density profiles are compared with a sample of elliptical galaxies, and the implications of the results for the development of stellar populations and galaxies are considered. 38 refs

  20. Comparative genomics in Chlamydomonas and Plasmodium identifies an ancient nuclear envelope protein family essential for sexual reproduction in protists, fungi, plants, and vertebrates.

    Science.gov (United States)

    Ning, Jue; Otto, Thomas D; Pfander, Claudia; Schwach, Frank; Brochet, Mathieu; Bushell, Ellen; Goulding, David; Sanders, Mandy; Lefebvre, Paul A; Pei, Jimin; Grishin, Nick V; Vanderlaan, Gary; Billker, Oliver; Snell, William J

    2013-05-15

    Fertilization is a crucial yet poorly characterized event in eukaryotes. Our previous discovery that the broadly conserved protein HAP2 (GCS1) functioned in gamete membrane fusion in the unicellular green alga Chlamydomonas and the malaria pathogen Plasmodium led us to exploit the rare biological phenomenon of isogamy in Chlamydomonas in a comparative transcriptomics strategy to uncover additional conserved sexual reproduction genes. All previously identified Chlamydomonas fertilization-essential genes fell into related clusters based on their expression patterns. Out of several conserved genes in a minus gamete cluster, we focused on Cre06.g280600, an ortholog of the fertilization-related Arabidopsis GEX1. Gene disruption, cell biological, and immunolocalization studies show that CrGEX1 functions in nuclear fusion in Chlamydomonas. Moreover, CrGEX1 and its Plasmodium ortholog, PBANKA_113980, are essential for production of viable meiotic progeny in both organisms and thus for mosquito transmission of malaria. Remarkably, we discovered that the genes are members of a large, previously unrecognized family whose first-characterized member, KAR5, is essential for nuclear fusion during yeast sexual reproduction. Our comparative transcriptomics approach provides a new resource for studying sexual development and demonstrates that exploiting the data can lead to the discovery of novel biology that is conserved across distant taxa.

  1. A Model of the Vela Supernova Remnant

    Science.gov (United States)

    Gvaramadze, Vasilii

    2000-10-01

    A model of the Vela supernova remnant (SNR) based on a cavity explosion of a supernova (SN) star is proposed. It is suggested that the general structure of the remnant is determined by the interaction of the SN blast wave with a massive shell created by the SN progenitor (15-20 M_solar) star. A possible origin of the nebula of hard X-ray emission detected around the Vela pulsar is discussed.

  2. Evolution of supernova remnants. III. Thermal waves

    International Nuclear Information System (INIS)

    Chevalier, R.A.

    1975-01-01

    The effect of heat conduction on the evolution of supernova remnants is investigated. A thermal wave, or electron conduction front, can travel more rapidly than a shock wave during the first thousand years of the remnant's evolution. A self-similar solution describing this phase has been found by Barenblatt. Numerical computations verify the solution and give the evolution past the thermal wave phase. While shell formation is not impeded, the interior density and temperature profiles are smoothed by the action of conduction

  3. Supernova Remnant in 3-D

    Science.gov (United States)

    2009-01-01

    [figure removed for brevity, see original site] Click on the image for the movie For the first time, a multiwavelength three-dimensional reconstruction of a supernova remnant has been created. This stunning visualization of Cassiopeia A, or Cas A, the result of an explosion approximately 330 years ago, uses data from several telescopes: X-ray data from NASA's Chandra X-ray Observatory, infrared data from NASA's Spitzer Space Telescope and optical data from the National Optical Astronomy Observatory 4-meter telescope at Kitt Peak, Ariz., and the Michigan-Dartmouth-MIT 2.4-meter telescope, also at Kitt Peak. In this visualization, the green region is mostly iron observed in X-rays. The yellow region is a combination of argon and silicon seen in X-rays, optical, and infrared including jets of silicon plus outer debris seen in the optical. The red region is cold debris seen in the infrared. Finally, the blue reveals the outer blast wave, most prominently detected in X-rays. Most of the material shown in this visualization is debris from the explosion that has been heated by a shock moving inwards. The red material interior to the yellow/orange ring has not yet encountered the inward moving shock and so has not yet been heated. These unshocked debris were known to exist because they absorb background radio light, but they were only recently discovered in infrared emission with Spitzer. The blue region is composed of gas surrounding the explosion that was heated when it was struck by the outgoing blast wave, as clearly seen in Chandra images. To create this visualization, scientists took advantage of both a previously known phenomenon the Doppler effect and a new technology that bridges astronomy and medicine. When elements created inside a supernova, such as iron, silicon and argon, are heated they emit light at certain wavelengths. Material moving towards the observer will have shorter wavelengths and material moving away will have longer wavelengths. Since the amount

  4. The nuclear envelopathies and human diseases

    Directory of Open Access Journals (Sweden)

    Jeang Kuan-Teh

    2009-10-01

    Full Text Available Abstract The nuclear envelope (NE consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intriguing connections between the envelope components and nuclear processes. Here, we review the functions of the nuclear envelope in chromosome organization, gene expression, DNA repair and cell cycle progression, and correlate deficiencies in envelope function with human pathologies.

  5. Early Site Permit Demonstration Program: Plant parameters envelope report

    International Nuclear Information System (INIS)

    1993-03-01

    The Early Site Permit (ESP) Demonstration Program is the nuclear industry's initiative for piloting the early resolution of siting-related issues before the detailed design proceedings of the combined operating license review. The ESP Demonstration Program consists of three phases. The plant parameters envelopes task is part of Phase 1, which addresses the generic review of applicable federal regulations and develops criteria for safety and environmental assessment of potential sites. The plant parameters envelopes identify parameters that characterize the interface between an ALWR design and a potential site, and quantify the interface through values selected from the Utility Requirements Documents, vendor design information, or engineering assessments. When augmented with site-specific information, the plant parameters envelopes provide sufficient information to allow ESPs to be granted based on individual ALWR design information or enveloping design information for the evolutionary, passive, or generic ALWR plants. This document is expected to become a living document when used by future applicants

  6. Radioiodine Remnant Ablation: A Critical Review

    International Nuclear Information System (INIS)

    Bal, Chandra Sekhar; Padhy, Ajit Kumar

    2015-01-01

    Radioiodine remnant ablation (RRA) is considered a safe and effective method for eliminating residual thyroid tissue, as well as microscopic disease if at all present in thyroid bed following thyroidectomy. The rationale of RRA is that in the absence of thyroid tissue, serum thyroglobulin (Tg) measurement can be used as an excellent tumor marker. Other considerations are like the presence of significant remnant thyroid tissue makes detection and treatment of nodal or distant metastases difficult. Rarely, microscopic disease in the thyroid bed if not ablated, in the future, could be a source of anaplastic transformation. On the other hand, microscopic tumor emboli in distant sites could be the cause of distant metastasis too. The ablation of remnant tissue would in all probability eliminate these theoretical risks. It may be noted that all these are unproven contentious issues except postablation serum Tg estimation that could be a good tumor marker for detecting early biochemical recurrence in long-term follow-up strategy. Radioactive iodine is administered as a form of “adjuvant therapy” for remnant ablation. There have been several reports with regard to the administered dose for remnant ablation. The first report of a prospective randomized clinical trial was published from India by a prospective randomized study conducted at the All India Institute of Medical Sciences, New Delhi in the year 1996. The study reported that increasing the empirical 131 I initial dose to more than 50 mCi results in plateauing of the dose-response curve and thus, conventional high-dose remnant ablation needs critical evaluation. Recently, two important studies were published: One from French group and the other from UK on a similar line. Interestingly, all three studies conducted in three different geographical regions of the world showed exactly similar conclusion. The new era of low-dose remnant ablation has taken a firm scientific footing across the continents

  7. Modelling the interaction of thermonuclear supernova remnants with circumstellar structures: the case of Tycho's supernova remnant

    NARCIS (Netherlands)

    Chiotellis, A.; Kosenko, D.; Schure, K.M.; Vink, J.; Kaastra, J.S.

    2013-01-01

    The well-established Type Ia remnant of Tycho's supernova (SN 1572) reveals discrepant ambient medium-density estimates based on either the measured dynamics or the X-ray emission properties. This discrepancy can potentially be solved by assuming that the supernova remnant (SNR) shock initially

  8. Autopsy of the Supernova Remnant Cassiopeia A

    Science.gov (United States)

    Milisavljevic, Dan; Fesen, Robert A.

    2014-01-01

    Three-dimensional kinematic reconstructions of optically emitting ejecta in the young Galactic supernova remnant Cassiopeia A (Cas A) are discussed. The reconstructions encompass the remnant's faint outlying ejecta knots, including the exceptionally high-velocity NE and SW streams of debris often referred to as `jets'. The bulk of Cas A's ejecta are arranged in several circular rings with diameters between approximately 30'' (0.5 pc) and 2' (2 pc). We suggest that similar large-scale ejecta rings may be a common phenomenon of young core-collapse remnants and may explain lumpy emission line profile substructure sometimes observed in spectra of extragalactic core-collapse supernovae years after explosion. A likely origin for these large ejecta rings is post-explosion input of energy from plumes of radioactive 56Ni-rich ejecta that rise, expand, and compress non-radioactive material to form bubble-like structures.

  9. Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 4: intercellular bridges, mitochondria, nuclear envelope, apoptosis, ubiquitination, membrane/voltage-gated channels, methylation/acetylation, and transcription factors.

    Science.gov (United States)

    Hermo, Louis; Pelletier, R-Marc; Cyr, Daniel G; Smith, Charles E

    2010-04-01

    As germ cells divide and differentiate from spermatogonia to spermatozoa, they share a number of structural and functional features that are common to all generations of germ cells and these features are discussed herein. Germ cells are linked to one another by large intercellular bridges which serve to move molecules and even large organelles from the cytoplasm of one cell to another. Mitochondria take on different shapes and features and topographical arrangements to accommodate their specific needs during spermatogenesis. The nuclear envelope and pore complex also undergo extensive modifications concomitant with the development of germ cell generations. Apoptosis is an event that is normally triggered by germ cells and involves many proteins. It occurs to limit the germ cell pool and acts as a quality control mechanism. The ubiquitin pathway comprises enzymes that ubiquitinate as well as deubiquitinate target proteins and this pathway is present and functional in germ cells. Germ cells express many proteins involved in water balance and pH control as well as voltage-gated ion channel movement. In the nucleus, proteins undergo epigenetic modifications which include methylation, acetylation, and phosphorylation, with each of these modifications signaling changes in chromatin structure. Germ cells contain specialized transcription complexes that coordinate the differentiation program of spermatogenesis, and there are many male germ cell-specific differences in the components of this machinery. All of the above features of germ cells will be discussed along with the specific proteins/genes and abnormalities to fertility related to each topic. Copyright 2009 Wiley-Liss, Inc.

  10. Cosmic Ray Acceleration in Supernova Remnants

    International Nuclear Information System (INIS)

    O'C Drury, Luke

    2005-01-01

    This paper describes some recent developments in our understanding of cosmic ray acceleration in supernova remnant shocks. It is pointed out that while good agreement now exists as to steady nonlinear modifications to the shock structure, there is also growing evidence that the mesoscopic scales may not in fact be steady and that significant instabilities associated with magnetic field amplification may be a feature of strong collisionless plasma shocks. There is strong observational evidence for such magnetic field amplification, and it appears to solve a number of long-standing issues concerned with acceleration of cosmic rays in supernova remnants

  11. X-ray haloes around supernova remnants

    International Nuclear Information System (INIS)

    Morfill, G.E.; Aschenbach, B.

    1984-01-01

    Recent observations of the Cas-A supernova remnant have shown X-ray emissions not only from the interior, but also from a fainter 'halo' extending beyond what is normally regarded as the outer boundary, or shock front. The authors suggest that this may be due to the diffusion of energetic, charged particles out of the remnant giving rise to precursor structure of the type predicted by the theory of diffusive shock acceleration. If this is the case we are seeing thermal emission from ambient gas heated by compression and wave dissipation. (author)

  12. X-ray haloes around supernova remnants

    Energy Technology Data Exchange (ETDEWEB)

    Morfill, G.E.; Aschenbach, B. (Max-Planck-Institut fuer Physik und Astrophysik, Garching (Germany, F.R.). Inst. fuer Extraterrestrische Physik); Drury, L.O' C. (Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany, F.R.))

    1984-09-27

    Recent observations of the Cas-A supernova remnant have shown X-ray emissions not only from the interior, but also from a fainter 'halo' extending beyond what is normally regarded as the outer boundary, or shock front. The authors suggest that this may be due to the diffusion of energetic charged particles out of the remnant giving rise to precursor structure of the type predicted by the theory of diffusive shock acceleration. If this is the case we are seeing thermal emission from ambient gas heated by compression and wave dissipation.

  13. OXYGEN-RICH SUPERNOVA REMNANT IN THE LARGE MAGELLANIC CLOUD

    Science.gov (United States)

    2002-01-01

    This is a NASA Hubble Space Telescope image of the tattered debris of a star that exploded 3,000 years ago as a supernova. This supernova remnant, called N132D, lies 169,000 light-years away in the satellite galaxy, the Large Magellanic Cloud. A Hubble Wide Field Planetary Camera 2 image of the inner regions of the supernova remnant shows the complex collisions that take place as fast moving ejecta slam into cool, dense interstellar clouds. This level of detail in the expanding filaments could only be seen previously in much closer supernova remnants. Now, Hubble's capabilities extend the detailed study of supernovae out to the distance of a neighboring galaxy. Material thrown out from the interior of the exploded star at velocities of more than four million miles per hour (2,000 kilometers per second) plows into neighboring clouds to create luminescent shock fronts. The blue-green filaments in the image correspond to oxygen-rich gas ejected from the core of the star. The oxygen-rich filaments glow as they pass through a network of shock fronts reflected off dense interstellar clouds that surrounded the exploded star. These dense clouds, which appear as reddish filaments, also glow as the shock wave from the supernova crushes and heats the clouds. Supernova remnants provide a rare opportunity to observe directly the interiors of stars far more massive than our Sun. The precursor star to this remnant, which was located slightly below and left of center in the image, is estimated to have been 25 times the mass of our Sun. These stars 'cook' heavier elements through nuclear fusion, including oxygen, nitrogen, carbon, iron etc., and the titanic supernova explosions scatter this material back into space where it is used to create new generations of stars. This is the mechanism by which the gas and dust that formed our solar system became enriched with the elements that sustain life on this planet. Hubble spectroscopic observations will be used to determine the exact

  14. The LHC on an envelope

    CERN Multimedia

    2007-01-01

    The series of envelopes featuring CERN issued this summer was a huge success. The French postal services of the Pays de Gex will shortly be launching the second set of pre-paid envelopes issued in collaboration with the Laboratory this year, this time highlighting the LHC. Five thousand envelopes describing the accelerator’s capabilities will go on sale on 12 November, and some of the packs will even contain a small sample of the cables from the heart of the LHC magnets. The sets of ten pre-paid envelopes will tell you everything about CERN’s flagship accelerator, from its astounding technical capabilities to its spin-offs in the fields of technology and human resources. Each envelope will feature a different attribute or spin-off of the LHC. People will be invited to consult CERN’s public website for more detailed explanations if they want to know more. The new envelopes will be available from five post offices in the Pays ...

  15. The LHC in an envelope

    CERN Multimedia

    2007-01-01

    The series of envelopes featuring CERN issued this summer was a huge success. The French postal services of the Pays de Gex will shortly be launching the second set of pre-paid envelopes issued in collaboration with the Laboratory this year, this time highlighting the LHC. Five thousand envelopes describing the accelerator’s capabilities will go on sale on 12 November, and some of the packs will even contain a small sample of the cables from the heart of the LHC magnets. The sets of ten pre-paid envelopes will tell you everything about CERN’s flagship accelerator, from its astounding technical capabilities to its spin-offs in the fields of technology and human resources. Each envelope will feature a different attribute or spin-off of the LHC. People will be invited to consult CERN’s public website for more detailed explanations if they want to know more. The new envelopes will be available from five post offices in the Pays de Gex (Ferney-Voltaire, Prévessin...

  16. The influence of thermal pressure on equilibrium models of hypermassive neutron star merger remnants

    Energy Technology Data Exchange (ETDEWEB)

    Kaplan, J. D.; Ott, C. D.; Roberts, L. [TAPIR, California Institute of Technology, Mailcode 350-17, Pasadena, CA 91125 (United States); O' Connor, E. P. [CITA, University of Toronto, 60 St. George Street, Toronto, ON M5S 3H8 (Canada); Kiuchi, K. [Yukawa Institute for Theoretical Physics, University of Kyoto, Kyoto (Japan); Duez, M., E-mail: cott@tapir.caltech.edu [Department of Physics and Astronomy, Washington State University, Pullman, WA (United States)

    2014-07-20

    The merger of two neutron stars leaves behind a rapidly spinning hypermassive object whose survival is believed to depend on the maximum mass supported by the nuclear equation of state (EOS), angular momentum redistribution by (magneto-)rotational instabilities, and spindown by gravitational waves. The high temperatures (∼5-40 MeV) prevailing in the merger remnant may provide thermal pressure support that could increase its maximum mass and, thus, its life on a neutrino-cooling timescale. We investigate the role of thermal pressure support in hypermassive merger remnants by computing sequences of spherically symmetric and axisymmetric uniformly and differentially rotating equilibrium solutions to the general-relativistic stellar structure equations. Using a set of finite-temperature nuclear EOS, we find that hot maximum-mass critically spinning configurations generally do not support larger baryonic masses than their cold counterparts. However, subcritically spinning configurations with mean density of less than a few times nuclear saturation density yield a significantly thermally enhanced mass. Even without decreasing the maximum mass, cooling and other forms of energy loss can drive the remnant to an unstable state. We infer secular instability by identifying approximate energy turning points in equilibrium sequences of constant baryonic mass parameterized by maximum density. Energy loss carries the remnant along the direction of decreasing gravitational mass and higher density until instability triggers collapse. Since configurations with more thermal pressure support are less compact and thus begin their evolution at a lower maximum density, they remain stable for longer periods after merger.

  17. The influence of thermal pressure on equilibrium models of hypermassive neutron star merger remnants

    International Nuclear Information System (INIS)

    Kaplan, J. D.; Ott, C. D.; Roberts, L.; O'Connor, E. P.; Kiuchi, K.; Duez, M.

    2014-01-01

    The merger of two neutron stars leaves behind a rapidly spinning hypermassive object whose survival is believed to depend on the maximum mass supported by the nuclear equation of state (EOS), angular momentum redistribution by (magneto-)rotational instabilities, and spindown by gravitational waves. The high temperatures (∼5-40 MeV) prevailing in the merger remnant may provide thermal pressure support that could increase its maximum mass and, thus, its life on a neutrino-cooling timescale. We investigate the role of thermal pressure support in hypermassive merger remnants by computing sequences of spherically symmetric and axisymmetric uniformly and differentially rotating equilibrium solutions to the general-relativistic stellar structure equations. Using a set of finite-temperature nuclear EOS, we find that hot maximum-mass critically spinning configurations generally do not support larger baryonic masses than their cold counterparts. However, subcritically spinning configurations with mean density of less than a few times nuclear saturation density yield a significantly thermally enhanced mass. Even without decreasing the maximum mass, cooling and other forms of energy loss can drive the remnant to an unstable state. We infer secular instability by identifying approximate energy turning points in equilibrium sequences of constant baryonic mass parameterized by maximum density. Energy loss carries the remnant along the direction of decreasing gravitational mass and higher density until instability triggers collapse. Since configurations with more thermal pressure support are less compact and thus begin their evolution at a lower maximum density, they remain stable for longer periods after merger.

  18. Protocol for thyroid remnant ablation after recombinant TSH in thyroid carcinoma

    International Nuclear Information System (INIS)

    Pitoia, F.; Salvai, M.E.; Niepomniszcze, H.; Tamer, E. El

    2009-01-01

    In some countries, in order to perform rhTSH-aided thyroid remnant ablation (TRA) after surgery, it is generally necessary to confirm that thyroidectomy has been almost complete. Otherwise, the nuclear medicine specialist will not administer a high radioiodine dose because it might be hazardous due to the possibility of thyroid remnant actinic thyroiditis. Considering this, it would be necessary to use two rhTSH kits (one for diagnostic purposes and the other one to administer the 131 I dose). In this study, we used an alternative protocol for TRA with the use of one kit of rhTSH in twenty patients diagnosed with low risk papillary thyroid carcinoma. All patients had negative titers of anti-thyroglobulin antibodies. Successful thyroid remnant ablation was confirmed with an undetectable rhTSH stimulated thyroglobulin level ( [es

  19. Particle acceleration and nonthermal radiation in supernova remnants

    International Nuclear Information System (INIS)

    Zirakashvili, Vladimir

    2013-01-01

    Cosmic ray acceleration and magnetic amplification in shell-type supernova remnants is shortly reviewed. The results on the modeling of broadband electromagnetic emission from supernova remnants are presented and compared with observations.

  20. GALACTIC AND EXTRAGALACTIC SUPERNOVA REMNANTS AS SITES OF PARTICLE ACCELERATION

    Directory of Open Access Journals (Sweden)

    Manami Sasaki

    2013-12-01

    Full Text Available Supernova remnants, owing to their strong shock waves, are likely sources of Galactic cosmic rays. Studies of supernova remnants in X-rays and gamma rays provide us with new insights into the acceleration of particles to high energies. This paper reviews the basic physics of supernova remnant shocks and associated particle acceleration and radiation processes. In addition, the study of supernova remnant populations in nearby galaxies and the implications for Galactic cosmic ray distribution are discussed.

  1. Safeguards Envelope Progress FY08

    International Nuclear Information System (INIS)

    Bean, Robert; Metcalf, Richard; Bevill, Aaron

    2008-01-01

    The Safeguards Envelope Project met its milestones by creating a rudimentary safeguards envelope, proving the value of the approach on a small scale, and determining the most appropriate path forward. The Idaho Chemical Processing Plant's large cache of reprocessing process monitoring data, dubbed UBER Data, was recovered and used in the analysis. A probabilistic Z test was used on a Markov Monte Carlo simulation of expected diversion data when compared with normal operating data. The data regarding a fully transient event in a tank was used to create a simple requirement, representative of a safeguards envelope, whose impact was a decrease in operating efficiency by 1.3% but an increase in material balance period of 26%. This approach is operator, state, and international safeguards friendly and should be applied to future reprocessing plants. Future requirements include tank-to-tank correlations in reprocessing facilities, detailed operations impact studies, simulation inclusion, automated optimization, advanced statistics analysis, and multi-attribute utility analysis

  2. Moisture dynamics in building envelopes

    Energy Technology Data Exchange (ETDEWEB)

    Peuhkuri, R.

    2003-07-01

    The overall scope of this Thesis 'Moisture dynamics in building envelopes' has been to characterise how the various porous insulation materials investigated performed hygro thermally under conditions similar to those in a typical building envelope. As a result of the changing temperature and moisture conditions in the exterior weather and indoor climate the materials dynamically absorb and release moisture. The complexity of the impact of these conditions on the resulting moisture transport and content of the materials has been studied in this Thesis with controlled laboratory tests. (au)

  3. Moisture Dynamics in Building Envelopes

    DEFF Research Database (Denmark)

    Peuhkuri, Ruut Hannele

    2003-01-01

    The overall scope of this Thesis "Moisture dynamics in building envelopes" has been to characterise how the various porous insulation materials investigated performed hygrothermally under conditions similar to those in a typical building envelope. As a result of the changing temperature...... part of the Thesis consists of a theory and literature review on the moisture storage and transport processes (Chapter 2), on the non-Fickian moisture transport (Chapter 3)and on the methods for determining the moisture properties (Chapter 4). In the second part, the conducted experimental work...

  4. Multi-dimensional simulations of the expanding supernova remnant of SN 1987A

    Energy Technology Data Exchange (ETDEWEB)

    Potter, T. M.; Staveley-Smith, L. [International center for Radio Astronomy Research (ICRAR) M468, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009 (Australia); Reville, B. [Center for Plasma Physics, Queen' s University Belfast, University Road, Belfast BT7 1NN (United Kingdom); Ng, C.-Y. [Department of Physics, The University of Hong Kong, Pokfulam Road (Hong Kong); Bicknell, G. V.; Sutherland, R. S. [Research School of Astronomy and Astrophysics, Australian National University, Canberra, ACT 0200 (Australia); Wagner, A. Y., E-mail: tobympotter@gmail.com [Center for Computational Sciences, Tsukuba University, Tsukuba, Ibaraki, 305-8577 (Japan)

    2014-10-20

    The expanding remnant from SN 1987A is an excellent laboratory for investigating the physics of supernovae explosions. There is still a large number of outstanding questions, such as the reason for the asymmetric radio morphology, the structure of the pre-supernova environment, and the efficiency of particle acceleration at the supernova shock. We explore these questions using three-dimensional simulations of the expanding remnant between days 820 and 10,000 after the supernova. We combine a hydrodynamical simulation with semi-analytic treatments of diffusive shock acceleration and magnetic field amplification to derive radio emission as part of an inverse problem. Simulations show that an asymmetric explosion, combined with magnetic field amplification at the expanding shock, is able to replicate the persistent one-sided radio morphology of the remnant. We use an asymmetric Truelove and McKee progenitor with an envelope mass of 10 M {sub ☉} and an energy of 1.5 × 10{sup 44} J. A termination shock in the progenitor's stellar wind at a distance of 0.''43-0.''51 provides a good fit to the turn on of radio emission around day 1200. For the H II region, a minimum distance of 0.''63 ± 0.''01 and maximum particle number density of (7.11 ± 1.78) × 10{sup 7} m{sup –3} produces a good fit to the evolving average radius and velocity of the expanding shocks from day 2000 to day 7000 after explosion. The model predicts a noticeable reduction, and possibly a temporary reversal, in the asymmetric radio morphology of the remnant after day 7000, when the forward shock left the eastern lobe of the equatorial ring.

  5. Neutron Star/supernova Remnant Associations

    Science.gov (United States)

    Gvaramadze, V. V.

    We propose a new approach for studying the neutron star/supernova remnant associations, based on the idea that the (diffuse) supernova remnants (SNRs) can be products of an off-centred supernova (SN) explosion in a preexisting bubble created by the wind of a moving massive star. A cavity SN explosion of a moving star results in a considerable offset of the neutron star (NS) birth-place from the geometrical centre of the SNR. Therefore: a) the high transverse velocities inferred for a number of NSs (e.g. PSR B 1610-50, PSR B 1757-24, SGR 0525-66) through their association with SNRs can be reduced; b) the proper motion vector of a NS should not necessarily point away from the geometrical centre of the associated SNR. Taking into account of these two facts allow us to enlarge the circle of possible NS/SNR associations, and could significantly affect the results of previous studies of NS/SNR associations. The possibilities of our approach are illustrated with the example of the association between PSR B 1706-44 and SNR G 343.1-2.3. We show that this association could be real if both objects are the remnants of a SN exploded within a mushroom-like cavity (created by the SN progenitor wind breaking out of the parent molecular cloud and expanding into an intercloud medium of a much less density). We also show that the SN explosion sites in some middle-aged (shell-like) SNRs could be marked by (compact) nebulae of thermal X-ray emission. The possible detection of such nebulae within middle-aged SNRs could be used for the re-estimation of implied transverse velocities of known NSs or for the search of new stellar remnants possibly associated with these SNRs.

  6. Supernova remnants in the GC region

    Science.gov (United States)

    Asvarov, Abdul

    2016-07-01

    Along with the central Black hole the processes of active star formation play very important role in the energetics of the Galactic center region. The SNe and their remnants (SNRs) are the main ingredients of the processes of star formation. SNRs are also the sources of electromagnetic radiation of all wavelengths from the optical to hard gamma rays. In the presented work we consider the physics of supernova remnants evolving in extreme environmental conditions which are typical for the region of the Galactic center. Because of the high density and strong inhomogeneity of the surrounding medium these objects remain practically invisible at almost all wavelengths. We model evolution of SNR taking into account the pressure of the surrounding medium and the gravitational field of the matter (stars, compact clouds, dark matter) inside the remnant. As it is well established, considerable portion of the kinetic energy of the SNR can be converted into the cosmic ray particles by diffusive shock acceleration mechanism. Therefore the effect of particle acceleration is also included in the model (with the effectiveness of acceleration as a free parameter). Using the observed radiation fluxes at different wavelengths we attempt to obtain limits on the parameters of the model of the Galactic Center, namely, the frequency of star birth, the average density of the matter and radiation field, etc.

  7. THE FIRST FERMI LAT SUPERNOVA REMNANT CATALOG

    Energy Technology Data Exchange (ETDEWEB)

    Acero, F.; Ballet, J. [Laboratoire AIM, CEA-IRFU/CNRS/Université Paris Diderot, Service d’Astrophysique, CEA Saclay, F-91191 Gif sur Yvette (France); Ackermann, M.; Buehler, R. [Deutsches Elektronen Synchrotron DESY, D-15738 Zeuthen (Germany); Ajello, M. [Department of Physics and Astronomy, Clemson University, Kinard Lab of Physics, Clemson, SC 29634-0978 (United States); Baldini, L. [Università di Pisa and Istituto Nazionale di Fisica Nucleare, Sezione di Pisa I-56127 Pisa (Italy); Barbiellini, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Bastieri, D.; Buson, S. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, I-35131 Padova (Italy); Bellazzini, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Bissaldi, E. [Istituto Nazionale di Fisica Nucleare, Sezione di Bari, I-70126 Bari (Italy); Blandford, R. D.; Bloom, E. D.; Bottacini, E.; Caliandro, G. A.; Cameron, R. A. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Bonino, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Torino, I-10125 Torino (Italy); Brandt, T. J. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Bregeon, J. [Laboratoire Univers et Particules de Montpellier, Université Montpellier, CNRS/IN2P3, Montpellier (France); Bruel, P., E-mail: francesco.depalma@ba.infn.it, E-mail: t.j.brandt@nasa.gov, E-mail: john.w.hewitt@unf.edu [Laboratoire Leprince-Ringuet, École polytechnique, CNRS/IN2P3, Palaiseau (France); and others

    2016-05-01

    To uniformly determine the properties of supernova remnants (SNRs) at high energies, we have developed the first systematic survey at energies from 1 to 100 GeV using data from the Fermi Large Area Telescope (LAT). Based on the spatial overlap of sources detected at GeV energies with SNRs known from radio surveys, we classify 30 sources as likely GeV SNRs. We also report 14 marginal associations and 245 flux upper limits. A mock catalog in which the positions of known remnants are scrambled in Galactic longitude allows us to determine an upper limit of 22% on the number of GeV candidates falsely identified as SNRs. We have also developed a method to estimate spectral and spatial systematic errors arising from the diffuse interstellar emission model, a key component of all Galactic Fermi LAT analyses. By studying remnants uniformly in aggregate, we measure the GeV properties common to these objects and provide a crucial context for the detailed modeling of individual SNRs. Combining our GeV results with multiwavelength (MW) data, including radio, X-ray, and TeV, we demonstrate the need for improvements to previously sufficient, simple models describing the GeV and radio emission from these objects. We model the GeV and MW emission from SNRs in aggregate to constrain their maximal contribution to observed Galactic cosmic rays.

  8. Radio evolution of young supernova remnants

    International Nuclear Information System (INIS)

    Shirkey, R.C. Jr.

    1976-01-01

    A one dimensional spherically symmetric magnetohydrodynamic code was developed to describe the evolution of the dynamical and radio properties of young supernova remnants. The code contains subroutines which treat the development of Rayleigh-Taylor instabilities wherever they arise in the remnant. Under the assumption of quasi-stationary equilibrium (dynamical changes considered slow in comparison to the time it takes the instability to achieve equilibrium) determined that the velocity of the instability is W approximately (a lambda)/sup 1 / 2 /, where a is the Rayleigh-Taylor acceleration and lambda is the wavelength of the instability. Subsequent processing of the kinetic energy of expansion, through turbulence, resulted in an increase in temperature and magnetic field strength. The model was used to analyze instability effects of density inhomogeneities in the interstellar medium on magnetic field amplification. A model was constructed for Cassiopeia A which gave good agreement with the measured dynamics, radio structure, and secular flux density decrease for the remnant. In order to compare observation with theory a computer routine was written that convolves the surface brightness at the source. The resultant convolved surface brightness graph is in good agreement with Rosenberg's observed ''model profile;'' differences between the graphs can be attributed to the asymmetric expansion of Cassiopeia A

  9. Nature of 'unseen' galactic envelopes

    International Nuclear Information System (INIS)

    McCrea, W.H.

    1983-01-01

    In this paper, it is suggested that unseen matter in a galactic envelope or in a group of galaxies may consist of substellar bodies originating as the first permanent 'stars' in the formation of a very massive galaxy according to a model for galaxy-formation on the basis of simple big-bang cosmology. (Auth.)

  10. Handbook on data envelopment analysis

    CERN Document Server

    Cooper, William W; Zhu, Joe

    2011-01-01

    Focusing on extensively used Data Envelopment Analysis topics, this volume aims to both describe the state of the field and extend the frontier of DEA research. New chapters include DEA models for DMUs, network DEA, models for supply chain operations and applications, and new developments.

  11. A solar-type star polluted by calcium-rich supernova ejecta inside the supernova remnant RCW 86

    Science.gov (United States)

    Gvaramadze, Vasilii V.; Langer, Norbert; Fossati, Luca; Bock, Douglas C.-J.; Castro, Norberto; Georgiev, Iskren Y.; Greiner, Jochen; Johnston, Simon; Rau, Arne; Tauris, Thomas M.

    2017-06-01

    When a massive star in a binary system explodes as a supernova, its companion star may be polluted with heavy elements from the supernova ejecta. Such pollution has been detected in a handful of post-supernova binaries 1 , but none of them is associated with a supernova remnant. We report the discovery of a binary G star strongly polluted with calcium and other elements at the position of the candidate neutron star [GV2003] N within the young galactic supernova remnant RCW 86. Our discovery suggests that the progenitor of the supernova that produced RCW 86 could have been a moving star, which exploded near the edge of its wind bubble and lost most of its initial mass because of common-envelope evolution shortly before core collapse, and that the supernova explosion might belong to the class of calcium-rich supernovae — faint and fast transients 2,3 , the origin of which is strongly debated 4-6 .

  12. Supernova Remnants with Fermi Large Area Telescope

    Directory of Open Access Journals (Sweden)

    Caragiulo M.

    2017-01-01

    Full Text Available The Large Area Telescope (LAT, on-board the Fermi satellite, proved to be, after 8 years of data taking, an excellent instrument to detect and observe Supernova Remnants (SNRs in a range of energies running from few hundred MeV up to few hundred GeV. It provides essential information on physical processes that occur at the source, involving both accelerated leptons and hadrons, in order to understand the mechanisms responsible for the primary Cosmic Ray (CR acceleration. We show the latest results in the observation of Galactic SNRs by Fermi-LAT.

  13. Runaway companions of supernova remnants with Gaia

    Science.gov (United States)

    Boubert, Douglas; Fraser, Morgan; Evans, N. Wyn

    2018-04-01

    It is expected that most massive stars have companions and thus that some core-collapse supernovae should have a runaway companion. The precise astrometry and photometry provided by Gaia allows for the systematic discovery of these runaway companions. We combine a prior on the properties of runaway stars from binary evolution with data from TGAS and APASS to search for runaway stars within ten nearby supernova remnants. We strongly confirm the existing candidate HD 37424 in S147, propose the Be star BD+50 3188 to be associated with HB 21, and suggest tentative candidates for the Cygnus and Monoceros Loops.

  14. VHE Gamma-ray Supernova Remnants

    Energy Technology Data Exchange (ETDEWEB)

    Funk, Stefan; /KIPAC, Menlo Park

    2007-01-22

    Increasing observational evidence gathered especially in X-rays and {gamma}-rays during the course of the last few years support the notion that Supernova remnants (SNRs) are Galactic particle accelerators up to energies close to the ''knee'' in the energy spectrum of Cosmic rays. This review summarizes the current status of {gamma}-ray observations of SNRs. Shell-type as well as plerionic type SNRs are addressed and prospect for observations of these two source classes with the upcoming GLAST satellite in the energy regime above 100 MeV are given.

  15. On neutron star/supernova remnant associations

    OpenAIRE

    Gvaramadze, V. V.

    2000-01-01

    It is pointed out that a cavity supernova (SN) explosion of a moving massive star could result in a significant offset of the neutron star (NS) birth-place from the geometrical centre of the supernova remnant (SNR). Therefore: a) the high implied transverse velocities of a number of NSs (e.g. PSR B1610-50, PSR B1757-24, SGR0525-66) could be reduced; b) the proper motion vector of a NS should not necessarily point away from the geometrical centre of the associated SNR; c) the circle of possibl...

  16. Remnant cholesterol as a cause of ischemic heart disease

    DEFF Research Database (Denmark)

    Varbo, Anette; Benn, Marianne; Nordestgaard, Børge G

    2014-01-01

    This review focuses on remnant cholesterol as a causal risk factor for ischemic heart disease (IHD), on its definition, measurement, atherogenicity, and levels in high risk patient groups; in addition, present and future pharmacological approaches to lowering remnant cholesterol levels...... are considered. Observational studies show association between elevated levels of remnant cholesterol and increased risk of cardiovascular disease, even when remnant cholesterol levels are defined, measured, or calculated in different ways. In-vitro and animal studies also support the contention that elevated...... levels of remnant cholesterol may cause atherosclerosis same way as elevated levels of low-density lipoprotein (LDL) cholesterol, by cholesterol accumulation in the arterial wall. Genetic studies of variants associated with elevated remnant cholesterol levels show that an increment of 1mmol/L (39mg...

  17. Are crab-type supernova remnants (plerions) short-lived

    International Nuclear Information System (INIS)

    Weiler, K.W.; Panagia, N.

    1978-01-01

    Arguments are given for a possible picture of the origin, maintenance, and lifetimes of the so-called Crab-like supernova remnants. It is suggested that these objects imply the existence of at least two distinct types of supernova events. A possible connection of the remnant types with the optically defined supernovae of Type I and Type II is discussed. Accepting that a pulsar is formed in at least some supernova events, the proposal is made that a rapidly rotating, rapidly slowing pulsar is necessary to create and maintain a Crab-like supernova remnant. Finally, arguments are presented that such a supernova remnant will be relatively short lived with respect to the more common shell-type of supernova remnant, perhaps surviving only 10000-20000 yr before fading into the Galactic background. The name of plerion is proposed for these filled-center supernova remnants and observational possiblities for confirming their nature are suggested. (orig.) [de

  18. Safeguards Envelope Progress FY08

    Energy Technology Data Exchange (ETDEWEB)

    Robert Bean; Richard Metcalf; Aaron Bevill

    2008-09-01

    The Safeguards Envelope Project met its milestones by creating a rudimentary safeguards envelope, proving the value of the approach on a small scale, and determining the most appropriate path forward. The Idaho Chemical Processing Plant’s large cache of reprocessing process monitoring data, dubbed UBER Data, was recovered and used in the analysis. A probabilistic Z test was used on a Markov Monte Carlo simulation of expected diversion data when compared with normal operating data. The data regarding a fully transient event in a tank was used to create a simple requirement, representative of a safeguards envelope, whose impact was a decrease in operating efficiency by 1.3% but an increase in material balance period of 26%. This approach is operator, state, and international safeguards friendly and should be applied to future reprocessing plants. Future requirements include tank-to-tank correlations in reprocessing facilities, detailed operations impact studies, simulation inclusion, automated optimization, advanced statistics analysis, and multi-attribute utility analysis.

  19. Transparent ceramic lamp envelope materials

    Energy Technology Data Exchange (ETDEWEB)

    Wei, G C [OSRAM SYLVANIA, 71 Cherry Hill Drive, Beverly, MA 01915 (United States)

    2005-09-07

    Transparent ceramic materials with optical qualities comparable to single crystals of similar compositions have been developed in recent years, as a result of the improved understanding of powder-processing-fabrication- sintering-property inter-relationships. These high-temperature materials with a range of thermal and mechanical properties are candidate envelopes for focused-beam, short-arc lamps containing various fills operating at temperatures higher than quartz. This paper reviews the composition, structure and properties of transparent ceramic lamp envelope materials including sapphire, small-grained polycrystalline alumina, aluminium oxynitride, yttrium aluminate garnet, magnesium aluminate spinel and yttria-lanthana. A satisfactory thermal shock resistance is required for the ceramic tube to withstand the rapid heating and cooling cycles encountered in lamps. Thermophysical properties, along with the geometry, size and thickness of a transparent ceramic tube, are important parameters in the assessment of its resistance to fracture arising from thermal stresses in lamps during service. The corrosive nature of lamp-fill liquid and vapour at high temperatures requires that all lamp components be carefully chosen to meet the target life. The wide range of new transparent ceramics represents flexibility in pushing the limit of envelope materials for improved beamer lamps.

  20. Application of FMEA-DEA (Failure Modes and Effect Analysis - Data Envelopment Analysis) to the air conditioning system of the control room a nuclear power plant; Aplicacao de FMEA-DEA ao sistema de ar condicionado da sala de controle de uma usina nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Barbosa, Junior, Gilberto Varanda

    2007-03-15

    This dissertation presents the FMEA-DEA analysis application to the air conditioning system of the control room of a nuclear power plant. After obtaining the failure modes, the index associated to the occurrence probability, the severity of the effects and the potential of detention, a priority order is established for the failure modes or deviations. This number is obtained by multiplying the three mentioned index that vary in a natural scale from 1 to 10, where the higher the index, the more critical the situation will be. In this work, it is intended to use a model based on the data envelopment analysis, DEA jointly with the FMEA, to identify the current efficiency of the system and which failure modes or deviations are considered more critical, and by means of the weights attributed for the mathematical modeling to identify which index are contributing more for these deviations. From this identification, improvements can be set, which may consider administrative changes, operator training and so on, thus adding value to the final product. (author)

  1. Evolution Models of Helium White Dwarf–Main-sequence Star Merger Remnants

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xianfei; Bi, Shaolan [Department of Astronomy, Beijing Normal University, Beijing, 100875 (China); Hall, Philip D.; Jeffery, C. Simon, E-mail: zxf@bnu.edu.cn [Armagh Observatory, College Hill, Armagh BT61 9DG (United Kingdom)

    2017-02-01

    It is predicted that orbital decay by gravitational-wave radiation and tidal interaction will cause some close binary stars to merge within a Hubble time. The merger of a helium-core white dwarf with a main-sequence (MS) star can produce a red giant branch star that has a low-mass hydrogen envelope when helium is ignited and thus become a hot subdwarf. Because detailed calculations have not been made, we compute post-merger models with a stellar evolution code. We find the evolutionary paths available to merger remnants and find the pre-merger conditions that lead to the formation of hot subdwarfs. We find that some such mergers result in the formation of stars with intermediate helium-rich surfaces. These stars later develop helium-poor surfaces owing to diffusion. Combining our results with a model population and comparing to observed stars, we find that some observed intermediate helium-rich hot subdwarfs can be explained as the remnants of the mergers of helium-core white dwarfs with low-mass MS stars.

  2. Evolution Models of Helium White Dwarf–Main-sequence Star Merger Remnants

    International Nuclear Information System (INIS)

    Zhang, Xianfei; Bi, Shaolan; Hall, Philip D.; Jeffery, C. Simon

    2017-01-01

    It is predicted that orbital decay by gravitational-wave radiation and tidal interaction will cause some close binary stars to merge within a Hubble time. The merger of a helium-core white dwarf with a main-sequence (MS) star can produce a red giant branch star that has a low-mass hydrogen envelope when helium is ignited and thus become a hot subdwarf. Because detailed calculations have not been made, we compute post-merger models with a stellar evolution code. We find the evolutionary paths available to merger remnants and find the pre-merger conditions that lead to the formation of hot subdwarfs. We find that some such mergers result in the formation of stars with intermediate helium-rich surfaces. These stars later develop helium-poor surfaces owing to diffusion. Combining our results with a model population and comparing to observed stars, we find that some observed intermediate helium-rich hot subdwarfs can be explained as the remnants of the mergers of helium-core white dwarfs with low-mass MS stars.

  3. Cortical processing of dynamic sound envelope transitions.

    Science.gov (United States)

    Zhou, Yi; Wang, Xiaoqin

    2010-12-08

    Slow envelope fluctuations in the range of 2-20 Hz provide important segmental cues for processing communication sounds. For a successful segmentation, a neural processor must capture envelope features associated with the rise and fall of signal energy, a process that is often challenged by the interference of background noise. This study investigated the neural representations of slowly varying envelopes in quiet and in background noise in the primary auditory cortex (A1) of awake marmoset monkeys. We characterized envelope features based on the local average and rate of change of sound level in envelope waveforms and identified envelope features to which neurons were selective by reverse correlation. Our results showed that envelope feature selectivity of A1 neurons was correlated with the degree of nonmonotonicity in their static rate-level functions. Nonmonotonic neurons exhibited greater feature selectivity than monotonic neurons in quiet and in background noise. The diverse envelope feature selectivity decreased spike-timing correlation among A1 neurons in response to the same envelope waveforms. As a result, the variability, but not the average, of the ensemble responses of A1 neurons represented more faithfully the dynamic transitions in low-frequency sound envelopes both in quiet and in background noise.

  4. Urachal remnant carcinoma - a rare entity

    Directory of Open Access Journals (Sweden)

    Vanesha Naidu

    2013-06-01

    Full Text Available Primary malignancy of the urachal remnant is a rare neoplasm that accounts for less than 0.01% of all adult cancers, with an estimated annual incidence of 1:5 million. The tumour carries a grave prognosis that attests to its highly aggressive nature. Owing to its extra-peritoneal location, the tumour runs a relatively silent clinical course until late presentation, when most patients display extensive local invasion and metastatic spread. In this report, we highlight a case of primary malignancy of the urachus that on initial clinical evaluation masqueraded as a Sister Mary Joseph’s nodule. Characteristic imaging features, however, proved decisive in establishing the diagnosis of a urachal carcinoma.

  5. A Python Calculator for Supernova Remnant Evolution

    Science.gov (United States)

    Leahy, D. A.; Williams, J. E.

    2017-05-01

    A freely available Python code for modeling supernova remnant (SNR) evolution has been created. This software is intended for two purposes: to understand SNR evolution and to use in modeling observations of SNR for obtaining good estimates of SNR properties. It includes all phases for the standard path of evolution for spherically symmetric SNRs. In addition, alternate evolutionary models are available, including evolution in a cloudy ISM, the fractional energy-loss model, and evolution in a hot low-density ISM. The graphical interface takes in various parameters and produces outputs such as shock radius and velocity versus time, as well as SNR surface brightness profile and spectrum. Some interesting properties of SNR evolution are demonstrated using the program.

  6. THE DRESSMAKER, REMNANTS OF A LIFE

    DEFF Research Database (Denmark)

    Carpe Pérez, Inmaculada Concepción

    2015-01-01

    The Dressmaker, remnants of a life, is a visual representation of our research in animation ,at the Animated Learning Lab, as a means of reflection on the construction of the self and memories. Through the artistic production of motion pictures, an introspection is done in the author’s personal...... knowledge, which help us to reflect upon thoughts, feelings and actions (personal or external). Such experiences shape our personalities and whose emotional balance our happiness depends on. Memories are the left over product out of experiences, constituents of a reality. This is seen and created...... the psychology of the self. Animation, for it’s metaphorical power and playfulness: mix of reality and fantasy, results a very attractive and effective tool to explore different points of view and work the neuroplasticity, facilitator of the physical changes of our brain and our behavior, area of study...

  7. Exosat observations of the Kepler supernova remnant

    International Nuclear Information System (INIS)

    Smith, A.; Peacock, A.; Arnaud, M.; Ballet, J.; Rothenflug, R.

    1989-01-01

    The medium-energy experiment on board Exosat was used to measure the X-ray spectrum of the Kepler supernova remnant over the range 1.5-10 keV. An Fe emission line was clearly resolved with an energy of about 6.5 keV and equivalent width of about 1.8 keV. This was superposed on a continuum with a temperature of 5.0(+3.8, -1.9) keV. The medium-energy spectrum is shown to be consistent with a model in which the Kepler SNR is presently in a Sedov phase of evolution, the 5 keV continuum arises from the shocked interstellar/circumstellar medium, and thermal (but not ionization) equilibrium exists between electrons and ions behind the primary shock front. However, in this case, an overabundance of iron by more than 6 times cosmic is required. 28 refs

  8. On Neutron Star/Supernova Remnant Association

    Science.gov (United States)

    Gvaramadze, V. V.

    It is pointed out that a cavity supernova (SN) explosion of a moving massive star could result in a significant offset of the neutron star (NS) birth-place from the geometrical centre of the supernova remnant (SNR). Therefore: a) the high implied transverse velocities of a number of NSs (e.g. PSR B1610-50, PSR B1706-44, PSR B1757-24, SGR 0526-66) could be reduced; b) the proper motion vector of a NS should not necessarily point away from the geometrical centre of the associated SNR; c) the circle of possible NS/SNR associations could be enlarged. An observational test is discussed, which could provide a determination of the true birth-places of NSs associated with middle-aged SNRs, and thereby provide more reliable estimates of their transverse velocities.

  9. Remnants of occipital vertebrae: proatlas segmentation abnormalities.

    Science.gov (United States)

    Menezes, Arnold H; Fenoy, Kathleen A

    2009-05-01

    Developmental remnants around the foramen magnum, or proatlas segmentation abnormalities, have been recorded in postmortem studies but very rarely in a clinical setting. Because of their rarity, the pathological anatomy has been misunderstood, and treatment has been fraught with failures. The objectives of this prospective study were to understand the correlative anatomy, pathology, and embryology and to recognize the clinical presentation and gain insights on the treatment and management. Our craniovertebral junction (CVJ) database started in 1977 and comprises 5200 cases. This prospective study has retrieval capabilities. Neurodiagnostic studies changed with the evolution of imaging. Seventy-two patients were recognized as having symptomatic proatlas segmentation abnormalities. Ventral bony masses from the clivus or medial occipital condyle occurred in 66% (44/72), lateral or anterolateral compressive masses in 37% (27 of 72 patients), and dorsal bony compression in 17% (12 of 72 patients). Hindbrain herniation was associated in 33%. The age at presentation was 3 to 23 years. Motor symptoms occurred in 72% (52 of 72 patients); palsies in Cranial Nerves IX, X, and XII in 33% (24 of 72 patients); and vertebrobasilar symptoms in 25% (18 of 72 patients). Trauma precipitated symptoms in 55% (40 of 72 patients). The best definition of the abnormality was demonstrated by 3-dimensional computed tomography combined with magnetic resonance imaging. Treatment was aimed at decompression of the pathology and stabilization. Remnants of the occipital vertebrae around the foramen magnum were recognized in 72 of 5200 CVJ cases (7.2%). Magnetic resonance imaging with 3-dimensional computed tomography of the CVJ provides the best definition and understanding of the lesions. Brainstem myelopathy and lower cranial nerve deficits are common clinical presentations in the first and second decades of life. Treatment is aimed at decompression of the pathology and CVJ stabilization.

  10. Benner's remnants: culture, tradition and everyday understanding.

    Science.gov (United States)

    Paley, John

    2002-06-01

    Benner's account of meaning and embodiment in nursing depends on a theory which she has never fully articulated, although she makes numerous allusions to it. Behind the background of shared meanings hovers something called 'culture', which provides each individual with meaning, determines what counts as real for her, and actively hands down interpretation-laden practices. This view is based, Benner claims, on the Heideggerian assumption that the meaning and organization of a culture precedes individual meaning-giving activity. I explore Benner's implicit view of culture, drawing on her published work over 15 years, and offer an appraisal of it. In doing so, I attempt to make sense of some rather strange remarks Benner has recently made about 'remnants' of Cartesian and Kantian thinking being found in the everyday understandings of people with asthma. The concept of culture is developed with reference to both Benner's own work and that of the anthropologist, Clifford Geertz, whose work she frequently cites. Having identified the principal tenets of what we might conveniently call the Benner-Geertz theory, I proceed to interrogate the theory, using the recent anthropological literature -- and, in particular, materialist attacks on the idea of culture as a system of meanings -- in order to cast doubt on it. I also review, very briefly, an alternative way of understanding 'culture', which is not vulnerable to the same criticisms. Benner's implicit theory of culture is revealed, somewhat ironically, as an inverted form of Cartesian dualism. Its intellectual provenance is not Heidegger, who appears to reject it, but the sort of American sociology associated with Talcott Parsons. As a corollary, it is suggested that Benner's 'remnants' analogy cannot be justified, and that the idea of Cartesian and Kantian concepts permeating Western culture, infecting both the providers and receivers of health care, is a myth.

  11. Supernova remnants and the origin of cosmic rays

    NARCIS (Netherlands)

    Vink, J.

    2014-01-01

    Supernova remnants have long been considered to be the dominant sources of Galactic cosmic rays. For a long time the prime evidence consisted of radio synchrotron radiation from supernova remnants, indicating the presence of electrons with energies of several GeV. However, in order to explain the

  12. Supernova Remnants as the Sources of Galactic Cosmic Rays

    NARCIS (Netherlands)

    Vink, J.

    2013-01-01

    The origin of cosmic rays holds still manymysteries hundred years after they were first discovered. Supernova remnants have for long been the most likely sources of Galactic cosmic rays. I discuss here some recent evidence that suggests that supernova remnants can indeed efficiently accelerate

  13. Relating Eye Activity Measures to Human Controller Remnant Characteristics

    NARCIS (Netherlands)

    Popovici, A; Zaal, P.M.T.; Pool, D.M.; Mulder, M.; Sawaragi, T

    2016-01-01

    This study attempts to partially explain the characteristics of the human perceptual remnant, following Levison’s representation of the remnant as an equivalent observation noise. Eye activity parameters are recorded using an eye tracker in two compensatory tracking tasks in which the visual

  14. [Recurrent neck abscess due to a branchial cleft remnant].

    Science.gov (United States)

    Kruijff, Schelto; Mastboom, Walter J; Vriens, Menno R; Sidhu, Stan B; Delbridge, Leigh W

    2013-01-01

    Abscesses arising from a third or fourth branchial cleft remnant are uncommon clinical entities and are often not recognised in a timely manner. In a 33-year-old female patient with a recurrent abscess in the left side of her neck, the cause turned out to be a fistula in the third branchial cleft remnant. She was treated initially with antibiotics and prednisone without adequate results. When the abscess was finally surgically drained, she became very ill and was admitted to the ICU with sepsis and multiple organ failure. She was discharged from hospital after six weeks. Four months later, a third-branchial cleft remnant was found during pharyngoscopy, immediately after which the cleft remnant fistula was excised and an ipsilateral hemi-thyroidectomy was performed. In young patients with recurring peri-thyroidal abscesses, a branchial cleft remnant should be considered a causative factor; this could avoid high morbidity and a delay in the appropriate treatment.

  15. Evolution of envelope solitons of ionization waves

    International Nuclear Information System (INIS)

    Ohe, K.; Hashimoto, M.

    1985-01-01

    The time evolution of a particle-like envelope soliton of ionization waves in plasma was investigated theoretically. The hydrodynamic equations of one spatial dimension were solved and the nonlinear dispersion relation was derived. For the amplitude of the wave the nonlinear Schroedinger equation was derived. Its soliton solution was interpreted as the envelope soliton which was experimentally found. The damping rate of the envelope soliton was estimated. (D.Gy.)

  16. Remnant Cholesterol Elicits Arterial Wall Inflammation and a Multilevel Cellular Immune Response in Humans

    NARCIS (Netherlands)

    Bernelot Moens, Sophie J.; Verweij, Simone L.; Schnitzler, Johan G.; Stiekema, Lotte C. A.; Bos, Merijn; Langsted, Anne; Kuijk, Carlijn; Bekkering, Siroon; Voermans, Carlijn; Verberne, Hein J.; Nordestgaard, Børge G.; Stroes, Erik S. G.; Kroon, Jeffrey

    2017-01-01

    Mendelian randomization studies revealed a causal role for remnant cholesterol in cardiovascular disease. Remnant particles accumulate in the arterial wall, potentially propagating local and systemic inflammation. We evaluated the impact of remnant cholesterol on arterial wall inflammation,

  17. THE FATE OF THE COMPACT REMNANT IN NEUTRON STAR MERGERS

    Energy Technology Data Exchange (ETDEWEB)

    Fryer, Chris L. [Department of Physics, The University of Arizona, Tucson, AZ 85721 (United States); Belczynski, Krzysztoff [Astronomical Observatory, University of Warsaw, Al Ujazdowskie 4, 00-478 Warsaw (Poland); Ramirez-Ruiz, Enrico [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Rosswog, Stephan [The Oskar klein Center, Department of Astronomy, AlbaNova, Stockholm University, SE-106 91 Stockholm (Sweden); Shen, Gang [Institute for Nuclear Theory, University of Washington, Seattle, WA 98195 (United States); Steiner, Andrew W. [Department of Physics and Astronomy, University of Tennessee, Knoxville, TN 37996 (United States)

    2015-10-10

    Neutron star (binary neutron star and neutron star–black hole) mergers are believed to produce short-duration gamma-ray bursts (GRBs). They are also believed to be the dominant source of gravitational waves to be detected by the advanced LIGO and advanced VIRGO and the dominant source of the heavy r-process elements in the universe. Whether or not these mergers produce short-duration GRBs depends sensitively on the fate of the core of the remnant (whether, and how quickly, it forms a black hole). In this paper, we combine the results of Newtonian merger calculations and equation of state studies to determine the fate of the cores of neutron star mergers. Using population studies, we can determine the distribution of these fates to compare to observations. We find that black hole cores form quickly only for equations of state that predict maximum non-rotating neutron star masses below 2.3–2.4 solar masses. If quick black hole formation is essential in producing GRBs, LIGO/Virgo observed rates compared to GRB rates could be used to constrain the equation of state for dense nuclear matter.

  18. Mosaic HIV envelope immunogenic polypeptides

    Science.gov (United States)

    Korber, Bette T. M.; Gnanakaran, S.; Perkins, Simon; Sodroski, Joseph; Haynes, Barton

    2018-01-02

    Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are sets of the disclosed mosaic Env polypeptides, which include two or more (for example, three) of the polypeptides. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject infected with HIV or at risk of HIV infection. In some embodiments, the methods include inducing an immune response to HIV in a subject comprising administering to the subject at least one (such as two, three, or more) of the immunogenic polypeptides or at least one (such as two, three, or more) nucleic acids encoding at least one of the immunogenic polypeptides disclosed herein.

  19. Induced wave propagation from a vibrating containment envelope

    International Nuclear Information System (INIS)

    Stout, R.B.; Thigpen, L.; Rambo, J.T.

    1985-09-01

    Low frequency wave forms are observed in the particle velocity measurements around the cavity and containment envelope formed by an underground nuclear test. The vibration solution for a spherical shell is used to formulate a model for the low frequency wave that propagates outward from this region. In this model the containment envelope is the zone of material that is crushed by the compressive shock wave of the nuclear explosion. The containment envelope is approximated by a spherical shell of material. The material in the spherical shell is densified and is given a relatively high kinetic energy density because of the high compressive stress and particle velocity of the shock wave. After the shock wave has propagated through the spherical shell, the spherical shell vibrates in order to dissipate the kinetic energy acquired from the shock wave. Based on the model, the frequency of vibration depends on the dimensions and material properties of the spherical shell. The model can also be applied in an inverse mode to obtain global estimates of averaged materials properties. This requires using experimental data and semi-empirical relationships involving the material properties. A particular case of estimating a value for shear strength is described. Finally, the oscillation time period of the lowest frequency from five nuclear tests is correlated with the energy of the explosion. The correlation provides another diagnostic to estimate the energy of a nuclear explosion. Also, the longest oscillation time period measurement provides additional experimental data that can be used to assess and validate various computer models. 11 refs., 2 figs

  20. Generation of Cosmic rays in Historical Supernova Remnants

    Directory of Open Access Journals (Sweden)

    Sinitsyna V.Y.

    2013-06-01

    Full Text Available We present the results of observations of two types of Galactic supernova remnants with the SHALON mirror Cherenkov telescope of Tien-Shan high-mountain Observatory: the shell-type supernova remnants Tycho, Cas A and IC 443; plerions Crab Nebula, 3c58(SN1181 and Geminga (probably plerion. The experimental data have confirmed the prediction of the theory about the hadronic generation mechanism of very high energy (800 GeV - 100 TeV gamma-rays in Tycho's supernova remnant. The data obtainedsuggest that the very high energy gamma-ray emission in the objects being discussedis different in origin.

  1. Revised Distances to 21 Supernova Remnants

    Science.gov (United States)

    Ranasinghe, S.; Leahy, D. A.

    2018-05-01

    We carry out a comprehensive study of H I 21 cm line observations and 13CO line observations of 21 supernova remnants (SNRs). The aim of the study is to search for H I absorption features to obtain kinematic distances in a consistent manner. The 21 SNRs are in the region of sky covered by the Very Large Array Galactic Plane Survey (H I 21 cm observations) and Galactic Ring Survey (13CO line observations). We obtain revised distances for 10 SNRs based on new evidence in the H I and 13CO observations. We revise distances for the other 11 SNRs based on an updated rotation curve and new error analysis. The mean change in distance for the 21 SNRs is ≃25%, i.e., a change of 1.5 kpc compared to a mean distance for the sample of 6.4 kpc. This has a significant impact on interpretation of the physical state of these SNRs. For example, using a Sedov model, age and explosion energy scale as the square of distance, and inferred ISM density scales as distance.

  2. Quantum remnants in the classical limit

    International Nuclear Information System (INIS)

    Kowalski, A.M.; Plastino, A.

    2016-01-01

    We analyze here the common features of two dynamical regimes: a quantum and a classical one. We deal with a well known semi-classic system in its route towards the classical limit, together with its purely classic counterpart. We wish to ascertain i) whether some quantum remnants can be found in the classical limit and ii) the details of the quantum-classic transition. The so-called mutual information is the appropriate quantifier for this task. Additionally, we study the Bandt–Pompe's symbolic patterns that characterize dynamical time series (representative of the semi-classical system under scrutiny) in their evolution towards the classical limit. - Highlights: • We investigate the classical limit (CL) of a well known semi classical model. • The study is made by reference to the Bandt Pompe symbolic approach. • The number and type of associated symbols changes as one proceeds towards the CL. • We ascertain which symbols pertaining to the quantum zone remain in the CL.

  3. Nonthermal Radiation from Supernova Remnant Shocks

    Directory of Open Access Journals (Sweden)

    Hyesung Kang

    2013-09-01

    Full Text Available Most of high energy cosmic rays (CRs are thought to be produced by diffusive shock acceleration (DSA at supernova remnants (SNRs within the Galaxy. Fortunately, nonthermal emissions from CR protons and electrons can provide direct observational evidence for such a model and place strong constraints on the complex nonlinear plasma processes in DSA theory. In this study we calculate the energy spectra of CR protons and electrons in Type Ia SNRs, using time-dependent DSA simulations that incorporate phenomenological models for some wave-particle interactions. We demonstrate that the timedependent evolution of the self-amplified magnetic fields, Alfvénic drift, and escape of the highest energy particles affect the energy spectra of accelerated protons and electrons, and so resulting nonthermal radiation spectrum. Especially, the spectral cutoffs in X-ray and γ-ray emission spectra are regulated by the evolution of the highest energy particles, which are injected at the early phase of SNRs. Thus detailed understandings of nonlinear wave-particle interactions and time-dependent DSA simulations of SNRs are crucial in testing the SNR hypothesis for the origin of Galactic cosmic rays.

  4. Radio emission from embryonic superluminous supernova remnants

    Science.gov (United States)

    Omand, Conor M. B.; Kashiyama, Kazumi; Murase, Kohta

    2018-02-01

    It has been widely argued that Type-I superluminous supernovae (SLSNe-I) are driven by powerful central engines with a long-lasting energy injection after the core-collapse of massive progenitors. One of the popular hypotheses is that the hidden engines are fast-rotating pulsars with a magnetic field of B ˜ 1013-1015 G. Murase, Kashiyama & Mészáros proposed that quasi-steady radio/submm emission from non-thermal electron-positron pairs in nascent pulsar wind nebulae can be used as a relevant counterpart of such pulsar-driven supernovae (SNe). In this work, focusing on the nascent SLSN-I remnants, we examine constraints that can be placed by radio emission. We show that the Atacama Large Millimeter/submillimetre Array can detect the radio nebula from SNe at DL ˜ 1 Gpc in a few years after the explosion, while the Jansky Very Large Array can also detect the counterpart in a few decades. The proposed radio follow-up observation could solve the parameter degeneracy in the pulsar-driven SN model for optical/UV light curves, and could also give us clues to young neutron star scenarios for SLSNe-I and fast radio bursts.

  5. Quantum remnants in the classical limit

    Energy Technology Data Exchange (ETDEWEB)

    Kowalski, A.M., E-mail: kowalski@fisica.unlp.edu.ar [Instituto de Física (IFLP-CCT-Conicet), Universidad Nacional de La Plata, C.C. 727, 1900 La Plata (Argentina); Comision de Investigaciones Científicas (CIC) (Argentina); Plastino, A., E-mail: plastino@fisica.unlp.edu.ar [Instituto de Física (IFLP-CCT-Conicet), Universidad Nacional de La Plata, C.C. 727, 1900 La Plata (Argentina); Argentina' s National Research Council (CONICET) (Argentina); SThAR, EPFL Innovation Park, Lausanne (Switzerland)

    2016-09-16

    We analyze here the common features of two dynamical regimes: a quantum and a classical one. We deal with a well known semi-classic system in its route towards the classical limit, together with its purely classic counterpart. We wish to ascertain i) whether some quantum remnants can be found in the classical limit and ii) the details of the quantum-classic transition. The so-called mutual information is the appropriate quantifier for this task. Additionally, we study the Bandt–Pompe's symbolic patterns that characterize dynamical time series (representative of the semi-classical system under scrutiny) in their evolution towards the classical limit. - Highlights: • We investigate the classical limit (CL) of a well known semi classical model. • The study is made by reference to the Bandt Pompe symbolic approach. • The number and type of associated symbols changes as one proceeds towards the CL. • We ascertain which symbols pertaining to the quantum zone remain in the CL.

  6. Predicting gravitational lensing by stellar remnants

    Science.gov (United States)

    Harding, Alexander J.; Stefano, R. Di; Lépine, S.; Urama, J.; Pham, D.; Baker, C.

    2018-03-01

    Gravitational lensing provides a means to measure mass that does not rely on detecting and analysing light from the lens itself. Compact objects are ideal gravitational lenses, because they have relatively large masses and are dim. In this paper, we describe the prospects for predicting lensing events generated by the local population of compact objects, consisting of 250 neutron stars, five black holes, and ≈35 000 white dwarfs. By focusing on a population of nearby compact objects with measured proper motions and known distances from us, we can measure their masses by studying the characteristics of any lensing event they generate. Here, we concentrate on shifts in the position of a background source due to lensing by a foreground compact object. With Hubble Space Telescope, JWST, and Gaia, measurable centroid shifts caused by lensing are relatively frequent occurrences. We find that 30-50 detectable events per decade are expected for white dwarfs. Because relatively few neutron stars and black holes have measured distances and proper motions, it is more difficult to compute realistic rates for them. However, we show that at least one isolated neutron star has likely produced detectable events during the past several decades. This work is particularly relevant to the upcoming data releases by the Gaia mission and also to data that will be collected by JWST. Monitoring predicted microlensing events will not only help to determine the masses of compact objects, but will also potentially discover dim companions to these stellar remnants, including orbiting exoplanets.

  7. Implementation of an Improved Safe Operating Envelope

    International Nuclear Information System (INIS)

    Prime, Robyn; McIntyre, Mark; Reeves, David

    2008-01-01

    This paper is a continuation of the paper presented at IYNC 2004 on 'The Definition of a Safe Operating Envelope'. The current paper concentrates on the implementation process of the Safe Operating Envelope employed at the Point Lepreau Generating Station. (authors)

  8. Physical properties of the red giant envelopes

    Energy Technology Data Exchange (ETDEWEB)

    Maciel, W J [Instituto de Astronomia e Geofisico da Universidade de Sao Paulo (Brazil)

    1978-12-01

    In this work, several model envelopes are calculated for cool giant stars with mass loss due to the action of stellar radiation pressure on molecules and grains. Molecular profiles as well as average values of some physical parameters of the envelopes are obtained.

  9. Physical properties of the red giant envelopes

    International Nuclear Information System (INIS)

    Maciel, W.J.

    1978-01-01

    In this work, several model envelopes are calculated for cool giant stars with mass loss due to the action of stellar radiation pressure on molecules and grains. Molecular profiles as well as average values of some physical parameters of the envelopes are obtained [pt

  10. Implementation of an Improved Safe Operating Envelope

    Energy Technology Data Exchange (ETDEWEB)

    Prime, Robyn; McIntyre, Mark [NB Power Nuclear, P.O. Box 600, Lepreau, NB (Canada); Reeves, David [Atlantic Nuclear Services Ltd., PO Box 1268 Fredericton, NB (Canada)

    2008-07-01

    This paper is a continuation of the paper presented at IYNC 2004 on 'The Definition of a Safe Operating Envelope'. The current paper concentrates on the implementation process of the Safe Operating Envelope employed at the Point Lepreau Generating Station. (authors)

  11. Early Site Permit Demonstration Program: Plant parameters envelope report. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-03-01

    The Early Site Permit (ESP) Demonstration Program is the nuclear industry`s initiative for piloting the early resolution of siting-related issues before the detailed design proceedings of the combined operating license review. The ESP Demonstration Program consists of three phases. The plant parameters envelopes task is part of Phase 1, which addresses the generic review of applicable federal regulations and develops criteria for safety and environmental assessment of potential sites. The plant parameters envelopes identify parameters that characterize the interface between an ALWR design and a potential site, and quantify the interface through values selected from the Utility Requirements Documents, vendor design information, or engineering assessments. When augmented with site-specific information, the plant parameters envelopes provide sufficient information to allow ESPs to be granted based on individual ALWR design information or enveloping design information for the evolutionary, passive, or generic ALWR plants. This document is expected to become a living document when used by future applicants.

  12. Monte Carlo investigation of the low-dose envelope from scanned proton pencil beams

    International Nuclear Information System (INIS)

    Sawakuchi, Gabriel O; Titt, Uwe; Mirkovic, Dragan; Ciangaru, George; Zhu, X Ronald; Sahoo, Narayan; Gillin, Michael T; Mohan, Radhe

    2010-01-01

    Scanned proton pencil beams carry a low-dose envelope that extends several centimeters from the individual beam's central axis. Thus, the total delivered dose depends on the size of the target volume and the corresponding number and intensity of beams necessary to cover the target volume uniformly. This dependence must be considered in dose calculation algorithms used by treatment planning systems. In this work, we investigated the sources of particles contributing to the low-dose envelope using the Monte Carlo technique. We used a validated model of our institution's scanning beam line to determine the contributions to the low-dose envelope from secondary particles created in a water phantom and particles scattered in beam line components. Our results suggested that, for high-energy beams, secondary particles produced by nuclear interactions in the water phantom are the major contributors to the low-dose envelope. For low-energy beams, the low-dose envelope is dominated by particles undergoing multiple Coulomb scattering in the beam line components and water phantom. Clearly, in the latter situation, the low-dose envelope depends directly on beam line design features. Finally, we investigated the dosimetric consequences of the low-dose envelope. Our results showed that if not modeled properly the low-dose envelope may cause clinically relevant dose disturbance in the target volume. This work suggested that this low-dose envelope is beam line specific for low-energy beams, should be thoroughly experimentally characterized and validated during commissioning of the treatment planning system, and therefore is of great concern for accurate delivery of proton scanning beam doses.

  13. Cystic duct remnant mucocele in a liver transplant recipient

    Energy Technology Data Exchange (ETDEWEB)

    Ahlawat, Sushil K. [Georgetown University Hospital, Department of Medicine, Division of Gastroenterology, Washington, DC (United States); University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ (United States); Fishbien, Thomas M. [Georgetown University Hospital, Department of Medicine, Division of Gastroenterology, Washington, DC (United States); Haddad, Nadim G. [Georgetown University Hospital, Department of Surgery, Division of Transplant Surgery, Washington, DC (United States)

    2008-08-15

    Cystic duct remnant mucocele is an extremely rare complication of liver transplantation in children. Surgical correction is usually required for cystic duct remnant mucocele when it causes biliary obstruction. We describe a 14-month-old liver transplant recipient who presented with biliary obstruction 1 month after orthotopic liver transplantation with an end-to-end choledochocholedocal biliary anastomosis for hepatoblastoma. US, CT and cholangiography findings were consistent with mucocele of the allograft cystic duct remnant. Surgery was not needed in our patient because the mucocele and biliary obstruction had resolved on repeat imaging most likely due to guidewire manipulation during cholangiography, resulting in opening of the cystic duct remnant orifice and drainage into the common duct. (orig.)

  14. Cystic duct remnant mucocele in a liver transplant recipient

    International Nuclear Information System (INIS)

    Ahlawat, Sushil K.; Fishbien, Thomas M.; Haddad, Nadim G.

    2008-01-01

    Cystic duct remnant mucocele is an extremely rare complication of liver transplantation in children. Surgical correction is usually required for cystic duct remnant mucocele when it causes biliary obstruction. We describe a 14-month-old liver transplant recipient who presented with biliary obstruction 1 month after orthotopic liver transplantation with an end-to-end choledochocholedocal biliary anastomosis for hepatoblastoma. US, CT and cholangiography findings were consistent with mucocele of the allograft cystic duct remnant. Surgery was not needed in our patient because the mucocele and biliary obstruction had resolved on repeat imaging most likely due to guidewire manipulation during cholangiography, resulting in opening of the cystic duct remnant orifice and drainage into the common duct. (orig.)

  15. Hydrodynamic Simulations of Kepler's Supernova Remnant

    Science.gov (United States)

    Sullivan, Jessica; Blondin, John; Borkowski, Kazik; Reynolds, Stephen

    2018-01-01

    Kepler’s supernova remnant contains unusual features that strongly suggest an origin in a single-degenerate Type Ia explosion, including anisotropic circumstellar medium (CSM), a strong brightness gradient, and spatially varying expansion proper motions. We present 3Dhydrodynamic simulations to test a picture in which Kepler's progenitor binary emitted a strong asymmetric wind, densest in the orbital plane, while the system moved at high velocity through the ISM. We simulate the creation of the presupernova environment as well as the supernova blast wave, using the VH-1 grid-based hydrodynamics code. We first modeled an anisotropic wind to create an asymmetric bowshock around the progenitor, then the blast wave from thesupernova. The final simulation places both previous model pieces onto a single grid and allows the blast wave to expand into the bowshock. Models were completed on a Yin-Yang grids with matching angular resolutions. By manipulating parameters that control the asymmetry of the system, we attempted to find conditions that recreated the current state of Kepler. We analyzed these models by comparing images of Kepler from the Chandra X-ray Observatory to line-of-sight projections from the model results. We also present comparisons of simulated expansion velocities with recent observations of X-ray proper motions from Chandra images. We were able to produce models that contained similar features to those seen in Kepler. We find the greatest resemblance to Kepler images with a presupernova wind with an equator-to-pole density contrast of 3 and a moderately disk-like CSM at a 5° angle between equatorial plane and system motion.

  16. Supernova Remnant Observations with Micro-X

    Science.gov (United States)

    Figueroa, Enectali

    Micro-X is a sounding rocket payload that combines an X-ray microcalorimeter with an imaging mirror to offer breakthrough science from high spectral resolution observations of extended X-ray sources. This payload has been in design and development for the last five years and is now completely built and undergoing integration; its first flight will be in November, 2012, as part of our current NASA award. This four-year follow-on proposal seeks funding for: (1) analysis of the first flight data, (2) the second flight and its data analysis, (3) development of payload upgrades and launch of the third flight, and (4) third flight data analysis. The scientific payload consists of a Transition Edge Sensor (TES) microcalorimeter array at the focus of a flight-proven conical imaging mirror. Micro-X capitalizes on three decades of NASA investment in the development of microcalorimeters and X-ray imaging optics. Micro-X offers a unique combination of bandpass, collecting area, and spectral and angular resolution. The spectral resolution goal across the 0.2 - 3.0 keV band is 2 - 4 eV Full-Width at Half Maximum (FWHM). The measured angular resolution of the mirror is 2.4 arcminute Half-Power Diameter (HPD). The effective area of the mirror, 300 square centimeters at 1 keV, is sufficient to provide observations of unprecedented quality of several astrophysical X-ray sources, even in a brief sounding rocket exposure of 300 sec. Our scientific program for this proposal will focus on supernova remnants (SNRs), whose spatial extent has made high-energy resolution observations with grating instruments extremely challenging. X-ray observations of SNRs with microcalorimeters will enable the study of the detailed atomic physics of the plasma; the determination of temperature, turbulence, and elemental abundances; and in conjunction with historical data, full three dimensional mapping of the kinematics of the remnant. These capabilities will open new avenues towards understanding the

  17. Injection envelope matching in storage rings

    International Nuclear Information System (INIS)

    Minty, M.G.; Spence, W.L.

    1995-05-01

    The shape and size of the transverse phase space injected into a storage ring can be deduced from turn-by-turn measurements of the transient behavior of the beam envelope in the ring. Envelope oscillations at 2 x the β-tron frequency indicate the presence of a β-mismatch, while envelope oscillations at the β-tron frequency are the signature of a dispersion function mismatch. Experiments in injection optimization using synchrotron radiation imaging of the beam and a fast-gated camera at the SLC damping rings are reported

  18. MHTGR thermal performance envelopes: Reliability by design

    International Nuclear Information System (INIS)

    Etzel, K.T.; Howard, W.W.; Zgliczynski, J.B.

    1992-05-01

    This document discusses thermal performance envelopes which are used to specify steady-state design requirements for the systems of the Modular High Temperature Gas-Cooled Reactor to maximize plant performance reliability with optimized design. The thermal performance envelopes are constructed around the expected operating point accounting for uncertainties in actual plant as-built parameters and plant operation. The components are then designed to perform successfully at all points within the envelope. As a result, plant reliability is maximized by accounting for component thermal performance variation in the design. The design is optimized by providing a means to determine required margins in a disciplined and visible fashion

  19. Interstellar and ejecta dust in the cas a supernova remnant

    Energy Technology Data Exchange (ETDEWEB)

    Arendt, Richard G. [CRESST, University of Maryland, Baltimore County, Baltimore, MD 21250 (United States); Dwek, Eli; Kober, Gladys [NASA Goddard Space Flight Center, Code 665, Greenbelt, MD 20771 (United States); Rho, Jeonghee [SETI Institute, 189 Bernardo Avenue, Mountain View, CA 94043 (United States); Hwang, Una, E-mail: Richard.G.Arendt@nasa.gov [NASA Goddard Space Flight Center, Code 662, Greenbelt, MD 20771 (United States)

    2014-05-01

    Infrared continuum observations provide a means of investigating the physical composition of the dust in the ejecta and swept up medium of the Cas A supernova remnant (SNR). Using low-resolution Spitzer IRS spectra (5-35 μm), and broad-band Herschel PACS imaging (70, 100, and 160 μm), we identify characteristic dust spectra, associated with ejecta layers that underwent distinct nuclear burning histories. The most luminous spectrum exhibits strong emission features at ∼9 and 21 μm and is closely associated with ejecta knots with strong Ar emission lines. The dust features can be reproduced by magnesium silicate grains with relatively low Mg to Si ratios. Another dust spectrum is associated with ejecta having strong Ne emission lines. It has no indication of any silicate features and is best fit by Al{sub 2}O{sub 3} dust. A third characteristic dust spectrum shows features that are best matched by magnesium silicates with a relatively high Mg to Si ratio. This dust is primarily associated with the X-ray-emitting shocked ejecta, but it is also evident in regions where shocked interstellar or circumstellar material is expected. However, the identification of dust composition is not unique, and each spectrum includes an additional featureless dust component of unknown composition. Colder dust of indeterminate composition is associated with emission from the interior of the SNR, where the reverse shock has not yet swept up and heated the ejecta. Most of the dust mass in Cas A is associated with this unidentified cold component, which is ≲ 0.1 M {sub ☉}. The mass of warmer dust is only ∼0.04 M {sub ☉}.

  20. SUPERNOVA REMNANT PROGENITOR MASSES IN M31

    Energy Technology Data Exchange (ETDEWEB)

    Jennings, Zachary G.; Williams, Benjamin F.; Dalcanton, Julianne J.; Gilbert, Karoline M.; Fouesneau, Morgan; Weisz, Daniel R. [Department of Astronomy, University of Washington Seattle, Box 351580, WA 98195 (United States); Murphy, Jeremiah W. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Dolphin, Andrew E., E-mail: zachjenn@uw.edu, E-mail: adolphin@raytheon.com [Raytheon, 1151 East Hermans Road, Tucson, AZ 85706 (United States)

    2012-12-10

    Using Hubble Space Telescope photometry, we age-date 59 supernova remnants (SNRs) in the spiral galaxy M31 and use these ages to estimate zero-age main-sequence masses (M{sub ZAMS}) for their progenitors. To accomplish this, we create color-magnitude diagrams (CMDs) and employ CMD fitting to measure the recent star formation history of the regions surrounding cataloged SNR sites. We identify any young coeval population that likely produced the progenitor star, then assign an age and uncertainty to that population. Application of stellar evolution models allows us to infer the M{sub ZAMS} from this age. Because our technique is not contingent on identification or precise location of the progenitor star, it can be applied to the location of any known SNRs. We identify significant young star formation around 53 of the 59 SNRs and assign progenitor masses to these, representing a factor of {approx}2 increase over currently measured progenitor masses. We consider the remaining six SNRs as either probable Type Ia candidates or the result of core-collapse progenitors that have escaped their birth sites. In general, the distribution of recovered progenitor masses is bottom-heavy, showing a paucity of the most massive stars. If we assume a single power-law distribution, dN/dM{proportional_to}M{sup {alpha}}, then we find a distribution that is steeper than a Salpeter initial mass function (IMF) ({alpha} = -2.35). In particular, we find values of {alpha} outside the range -2.7 {>=} {alpha} {>=} -4.4 to be inconsistent with our measured distribution at 95% confidence. If instead we assume a distribution that follows a Salpeter IMF up to some maximum mass, then we find that values of M{sub Max} > 26 are inconsistent with the measured distribution at 95% confidence. In either scenario, the data suggest that some fraction of massive stars may not explode. The result is preliminary and requires more SNRs and further analysis. In addition, we use our distribution to estimate a

  1. Constructing canonical bases of quantized enveloping algebras

    OpenAIRE

    Graaf, W.A. de

    2001-01-01

    An algorithm for computing the elements of a given weight of the canonical basis of a quantized enveloping algebra is described. Subsequently, a similar algorithm is presented for computing the canonical basis of a finite-dimensional module.

  2. Complex structure of the supernova remnant HB 3

    Science.gov (United States)

    Leahy, D. A.; Venkatesan, D.; Long, K. S.; Naranan, S.

    1985-01-01

    HB 3 is an old, large (84 pc diameter) supernova remnant associated with the W3 H II region/molecular cloud complex. Observations of the imaging proportional counter (IPC) onboard the Einstein X-ray astronomy satellite have been reprocessed to yield a contour map of X-ray brightness and spectra of various regions of this remnant. The measured IPC flux is 2.4 x 10 to the -11th ergs per sq cm per s, giving a 0.2-4 keV luminosity of 1.6 x 10 to the 35th ergs/s for a column densityof 6 x 10 to the 21st per sq cm. The measured X-ray temperatures reveal a decrease from center to limb of the remnant of 1-0.3 keV. HB 3 is in the late adiabatic blast-wave phase of evolution, 30,000 to 50,000 yr old and with an initial blast energy of 3 x 10 to the 50th ergs. The X-ray map is compared with available radio and optical images. In X-rays, HB 3 has two components - a diffuse emission inside the 84 pc radio remnant and a ring of emission at the center of 30 pc in diameter. The diffuse emission is similar to that from other supernova remnants which are moderately obscured (column density, nH approximately 10 to the 22nd per sq cm). Three possibilities for the origin of the ring are explored: (1) a second supernova remnant, (2) a shocked shell in the interstellar medium surrounding HB 3, and (3) reverse-shock heated ejecta. There is no hot neutron star within the remnant.

  3. Creating a Lunar EVA Work Envelope

    Science.gov (United States)

    Griffin, Brand N.; Howard, Robert; Rajulu, Sudhakar; Smitherman, David

    2009-01-01

    A work envelope has been defined for weightless Extravehicular Activity (EVA) based on the Space Shuttle Extravehicular Mobility Unit (EMU), but there is no equivalent for planetary operations. The weightless work envelope is essential for planning all EVA tasks because it determines the location of removable parts, making sure they are within reach and visibility of the suited crew member. In addition, using the envelope positions the structural hard points for foot restraints that allow placing both hands on the job and provides a load path for reacting forces. EVA operations are always constrained by time. Tasks are carefully planned to ensure the crew has enough breathing oxygen, cooling water, and battery power. Planning first involves computers using a virtual work envelope to model tasks, next suited crew members in a simulated environment refine the tasks. For weightless operations, this process is well developed, but planetary EVA is different and no work envelope has been defined. The primary difference between weightless and planetary work envelopes is gravity. It influences anthropometry, horizontal and vertical mobility, and reaction load paths and introduces effort into doing "overhead" work. Additionally, the use of spacesuits other than the EMU, and their impacts on range of motion, must be taken into account. This paper presents the analysis leading to a concept for a planetary EVA work envelope with emphasis on lunar operations. There is some urgency in creating this concept because NASA has begun building and testing development hardware for the lunar surface, including rovers, habitats and cargo off-loading equipment. Just as with microgravity operations, a lunar EVA work envelope is needed to guide designers in the formative stages of the program with the objective of avoiding difficult and costly rework.

  4. All the Universe in an envelope

    CERN Multimedia

    2007-01-01

    Do you know which force is hidden in an envelope or how many billions of years old are the atoms it contains? You will find the answers to these (curious) questions in a post office in the Pays de Gex. The French postal services of the Pays de Gex are again issuing pre-paid envelopes in collaboration with CERN (see Bulletin No. 24/2006). The new series presents some of the concepts of modern physics in an amazing way by showing what you can learn about the Universe with a single envelope. Packets of ten pre-stamped envelopes, each carrying a statement on fundamental physics, will be on sale from 7 July onwards. To learn more about the physics issues presented on the envelopes, people are invited to go to the CERN Web site where they will find the explanations. Five thousand envelopes will be put on sale in July and five thousand more during the French "Fête de la science" in October. They will be available from five post offices in the Pays de Gex (F...

  5. Genetic Diversity of Koala Retroviral Envelopes

    Directory of Open Access Journals (Sweden)

    Wenqin Xu

    2015-03-01

    Full Text Available Genetic diversity, attributable to the low fidelity of reverse transcription, recombination and mutation, is an important feature of infectious retroviruses. Under selective pressure, such as that imposed by superinfection interference, gammaretroviruses commonly adapt their envelope proteins to use alternative receptors to overcome this entry block. The first characterized koala retroviruses KoRV subgroup A (KoRV-A were remarkable in their absence of envelope genetic variability. Once it was determined that KoRV-A was present in all koalas in US zoos, regardless of their disease status, we sought to isolate a KoRV variant whose presence correlated with neoplastic malignancies. More than a decade after the identification of KoRV-A, we isolated a second subgroup of KoRV, KoRV-B from koalas with lymphomas. The envelope proteins of KoRV-A and KoRV-B are sufficiently divergent to confer the ability to bind and employ distinct receptors for infection. We have now obtained a number of additional KoRV envelope variants. In the present studies we report these variants, and show that they differ from KoRV-A and KoRV-B envelopes in their host range and superinfection interference properties. Thus, there appears to be considerable variation among KoRVs envelope genes suggesting genetic diversity is a factor following the KoRV-A infection process.

  6. Black hole remnants and the information loss paradox

    Energy Technology Data Exchange (ETDEWEB)

    Chen, P., E-mail: pisinchen@phys.ntu.edu.tw [Leung Center for Cosmology and Particle Astrophysics, National Taiwan University, Taipei 10617, Taiwan (China); Graduate Institute of Astrophysics, National Taiwan University, Taipei 10617, Taiwan (China); Department of Physics, National Taiwan University, Taipei 10617, Taiwan (China); Kavli Institute for Particle Astrophysics and Cosmology, SLAC National Accelerator Laboratory, Stanford University, CA 94305 (United States); Ong, Y.C., E-mail: yenchin.ong@nordita.org [Nordita, KTH Royal Institute of Technology and Stockholm University, Roslagstullsbacken 23, SE-106 91 Stockholm (Sweden); Yeom, D.-H., E-mail: innocent.yeom@gmail.com [Leung Center for Cosmology and Particle Astrophysics, National Taiwan University, Taipei 10617, Taiwan (China)

    2015-11-22

    Forty years after the discovery of Hawking radiation, its exact nature remains elusive. If Hawking radiation does not carry any information out from the ever shrinking black hole, it seems that unitarity is violated once the black hole completely evaporates. On the other hand, attempts to recover information via quantum entanglement lead to the firewall controversy. Amid the confusions, the possibility that black hole evaporation stops with a “remnant” has remained unpopular and is often dismissed due to some “undesired properties” of such an object. Nevertheless, as in any scientific debate, the pros and cons of any proposal must be carefully scrutinized. We fill in the void of the literature by providing a timely review of various types of black hole remnants, and provide some new thoughts regarding the challenges that black hole remnants face in the context of the information loss paradox and its latest incarnation, namely the firewall controversy. The importance of understanding the role of curvature singularity is also emphasized, after all there remains a possibility that the singularity cannot be cured even by quantum gravity. In this context a black hole remnant conveniently serves as a cosmic censor. We conclude that a remnant remains a possible end state of Hawking evaporation, and if it contains large interior geometry, may help to ameliorate the information loss paradox and the firewall controversy. We hope that this will raise some interests in the community to investigate remnants more critically but also more thoroughly.

  7. Black hole remnants and the information loss paradox

    International Nuclear Information System (INIS)

    Chen, P.; Ong, Y.C.; Yeom, D.-H.

    2015-01-01

    Forty years after the discovery of Hawking radiation, its exact nature remains elusive. If Hawking radiation does not carry any information out from the ever shrinking black hole, it seems that unitarity is violated once the black hole completely evaporates. On the other hand, attempts to recover information via quantum entanglement lead to the firewall controversy. Amid the confusions, the possibility that black hole evaporation stops with a “remnant” has remained unpopular and is often dismissed due to some “undesired properties” of such an object. Nevertheless, as in any scientific debate, the pros and cons of any proposal must be carefully scrutinized. We fill in the void of the literature by providing a timely review of various types of black hole remnants, and provide some new thoughts regarding the challenges that black hole remnants face in the context of the information loss paradox and its latest incarnation, namely the firewall controversy. The importance of understanding the role of curvature singularity is also emphasized, after all there remains a possibility that the singularity cannot be cured even by quantum gravity. In this context a black hole remnant conveniently serves as a cosmic censor. We conclude that a remnant remains a possible end state of Hawking evaporation, and if it contains large interior geometry, may help to ameliorate the information loss paradox and the firewall controversy. We hope that this will raise some interests in the community to investigate remnants more critically but also more thoroughly.

  8. Solitary Alfven wave envelopes and the modulational instability

    International Nuclear Information System (INIS)

    Kennel, C.F.

    1987-06-01

    The derivative nonlinear Schroedinger equation describes the modulational instability of circularly polarized dispersive Alfven wave envelopes. It also may be used to determine the properties of finite amplitude localized stationary wave envelopes. Such envelope solitons exist only in conditions of modulational stability. This leaves open the question of whether, and if so, how, the modulational instability produces envelope solitons. 12 refs

  9. Planck intermediate results XXXI. Microwave survey of Galactic supernova remnants

    DEFF Research Database (Denmark)

    Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.

    2016-01-01

    The all-sky Planck survey in 9 frequency bands was used to search for emission from all 274 known Galactic supernova remnants. Of these, 16 were detected in at least two Planck frequencies. The radio-through-microwave spectral energy distributions were compiled to determine the mechanism for micr......The all-sky Planck survey in 9 frequency bands was used to search for emission from all 274 known Galactic supernova remnants. Of these, 16 were detected in at least two Planck frequencies. The radio-through-microwave spectral energy distributions were compiled to determine the mechanism...... for microwave emission. In only one case, IC 443, is there high-frequency emission clearly from dust associated with the supernova remnant. In all cases, the low-frequency emission is from synchrotron radiation. As predicted for a population of relativistic particles with energy distribution that extends...

  10. Case report of bilateral cervical chondrocutaneous branchial remnants.

    Science.gov (United States)

    Braun, Hannes; Hofmann, Thiemo; Wolfgruber, Herwig; Anderhuber, Wolfgang; Beham, Alfred; Stammberger, Heinz

    2003-01-01

    Cervical chondrocutaneous branchial remnants are rare and not well known lesions. Histologically the lesion per definition presents as a Choristoma. Choristoma is the pathohistological term for a developmental tumor-like anomaly consisting of tissues foreign to the site at which it is located. Treatment is complete surgical removal as promptly as possible in order to get an exact histopathological diagnosis. A case of a 4-month-old boy with cervical chondrocutaneous branchial remnants anterior to the sternocleidomastoid muscles on both sides is presented. According to literature search this appears to be the second case published on such a bilateral lesion.

  11. The acceleration of cosmic rays in supernova remnants

    International Nuclear Information System (INIS)

    Bhat, C.L.; Issa, M.R.

    1986-01-01

    The idea that the bulk of cosmic rays below 10 GeV are accelerated in supernova remnants suggests that cosmic rays should also exhibit intensity variations on a scale comparable with the linear size of a representative remnant. Following the general spirit of shock-wave acceleration models, here Monte Carlo simulations are carried out to predict what this scale should be and then corroborative evidence is presented from an autocorrelation analysis of the COS B and SAS II γ-ray data for the latitude range |b|=10-20 0 ('near Galaxy') and |b| 0 ('far Galaxy'). (author)

  12. Inhibition of enveloped viruses infectivity by curcumin.

    Directory of Open Access Journals (Sweden)

    Tzu-Yen Chen

    Full Text Available Curcumin, a natural compound and ingredient in curry, has antiinflammatory, antioxidant, and anticarcinogenic properties. Previously, we reported that curcumin abrogated influenza virus infectivity by inhibiting hemagglutination (HA activity. This study demonstrates a novel mechanism by which curcumin inhibits the infectivity of enveloped viruses. In all analyzed enveloped viruses, including the influenza virus, curcumin inhibited plaque formation. In contrast, the nonenveloped enterovirus 71 remained unaffected by curcumin treatment. We evaluated the effects of curcumin on the membrane structure using fluorescent dye (sulforhodamine B; SRB-containing liposomes that mimic the viral envelope. Curcumin treatment induced the leakage of SRB from these liposomes and the addition of the influenza virus reduced the leakage, indicating that curcumin disrupts the integrity of the membranes of viral envelopes and of liposomes. When testing liposomes of various diameters, we detected higher levels of SRB leakage from the smaller-sized liposomes than from the larger liposomes. Interestingly, the curcumin concentration required to reduce plaque formation was lower for the influenza virus (approximately 100 nm in diameter than for the pseudorabies virus (approximately 180 nm and the vaccinia virus (roughly 335 × 200 × 200 nm. These data provide insights on the molecular antiviral mechanisms of curcumin and its potential use as an antiviral agent for enveloped viruses.

  13. Featured Image: Orbiting Stars Share an Envelope

    Science.gov (United States)

    Kohler, Susanna

    2016-03-01

    This beautiful series of snapshots from a simulation (click for a better look!) shows what happens when two stars in a binary system become enclosed in the same stellar envelope. In this binary system, one of the stars has exhausted its hydrogen fuel and become a red giant, complete with an expanding stellar envelope composed of hydrogen and helium. Eventually, the envelope expands so much that the companion star falls into it, where it releases gravitational potential energy into the common envelope. A team led by Sebastian Ohlmann (Heidelberg Institute for Theoretical Studies and University of Wrzburg) recently performed hydrodynamic simulations of this process. Ohlmann and collaborators discovered that the energy release eventually triggers large-scale flow instabilities, which leads to turbulence within the envelope. This process has important consequences for how these systems next evolve (for instance, determining whether or not a supernova occurs!). You can check out the authors video of their simulated stellar inspiral below, or see their paper for more images and results from their study.CitationSebastian T. Ohlmann et al 2016 ApJ 816 L9. doi:10.3847/2041-8205/816/1/L9

  14. Inhibition of Enveloped Viruses Infectivity by Curcumin

    Science.gov (United States)

    Wen, Hsiao-Wei; Ou, Jun-Lin; Chiou, Shyan-Song; Chen, Jo-Mei; Wong, Min-Liang; Hsu, Wei-Li

    2013-01-01

    Curcumin, a natural compound and ingredient in curry, has antiinflammatory, antioxidant, and anticarcinogenic properties. Previously, we reported that curcumin abrogated influenza virus infectivity by inhibiting hemagglutination (HA) activity. This study demonstrates a novel mechanism by which curcumin inhibits the infectivity of enveloped viruses. In all analyzed enveloped viruses, including the influenza virus, curcumin inhibited plaque formation. In contrast, the nonenveloped enterovirus 71 remained unaffected by curcumin treatment. We evaluated the effects of curcumin on the membrane structure using fluorescent dye (sulforhodamine B; SRB)-containing liposomes that mimic the viral envelope. Curcumin treatment induced the leakage of SRB from these liposomes and the addition of the influenza virus reduced the leakage, indicating that curcumin disrupts the integrity of the membranes of viral envelopes and of liposomes. When testing liposomes of various diameters, we detected higher levels of SRB leakage from the smaller-sized liposomes than from the larger liposomes. Interestingly, the curcumin concentration required to reduce plaque formation was lower for the influenza virus (approximately 100 nm in diameter) than for the pseudorabies virus (approximately 180 nm) and the vaccinia virus (roughly 335 × 200 × 200 nm). These data provide insights on the molecular antiviral mechanisms of curcumin and its potential use as an antiviral agent for enveloped viruses. PMID:23658730

  15. PROGENITOR-EXPLOSION CONNECTION AND REMNANT BIRTH MASSES FOR NEUTRINO-DRIVEN SUPERNOVAE OF IRON-CORE PROGENITORS

    Energy Technology Data Exchange (ETDEWEB)

    Ugliano, Marcella; Janka, Hans-Thomas; Marek, Andreas [Max-Planck-Institut fuer Astrophysik, Karl-Schwarzschild-Str. 1, D-85748 Garching (Germany); Arcones, Almudena [Institut fuer Kernphysik, Technische Universitaet Darmstadt, Schlossgartenstr. 2, D-64289 Darmstadt (Germany)

    2012-09-20

    We perform hydrodynamic supernova (SN) simulations in spherical symmetry for over 100 single stars of solar metallicity to explore the progenitor-explosion and progenitor-remnant connections established by the neutrino-driven mechanism. We use an approximative treatment of neutrino transport and replace the high-density interior of the neutron star (NS) by an inner boundary condition based on an analytic proto-NS core-cooling model, whose free parameters are chosen such that explosion energy, nickel production, and energy release by the compact remnant of progenitors around 20 M{sub Sun} are compatible with SN 1987A. Thus, we are able to simulate the accretion phase, initiation of the explosion, subsequent neutrino-driven wind phase for 15-20 s, and the further evolution of the blast wave for hours to days until fallback is completed. Our results challenge long-standing paradigms. We find that remnant mass, launch time, and properties of the explosion depend strongly on the stellar structure and exhibit large variability even in narrow intervals of the progenitors' zero-age main-sequence mass. While all progenitors with masses below {approx}15 M{sub Sun} yield NSs, black hole (BH) as well as NS formation is possible for more massive stars, where partial loss of the hydrogen envelope leads to weak reverse shocks and weak fallback. Our NS baryonic masses of {approx}1.2-2.0 M{sub Sun} and BH masses >6 M{sub Sun} are compatible with a possible lack of low-mass BHs in the empirical distribution. Neutrino heating accounts for SN energies between some 10{sup 50} erg and {approx}2 Multiplication-Sign 10{sup 51} erg but can hardly explain more energetic explosions and nickel masses higher than 0.1-0.2 M{sub Sun }. These seem to require an alternative SN mechanism.

  16. Nuclear networking.

    Science.gov (United States)

    Xie, Wei; Burke, Brian

    2017-07-04

    Nuclear lamins are intermediate filament proteins that represent important structural components of metazoan nuclear envelopes (NEs). By combining proteomics and superresolution microscopy, we recently reported that both A- and B-type nuclear lamins form spatially distinct filament networks at the nuclear periphery of mouse fibroblasts. In particular, A-type lamins exhibit differential association with nuclear pore complexes (NPCs). Our studies reveal that the nuclear lamina network in mammalian somatic cells is less ordered and more complex than that of amphibian oocytes, the only other system in which the lamina has been visualized at high resolution. In addition, the NPC component Tpr likely links NPCs to the A-type lamin network, an association that appears to be regulated by C-terminal modification of various A-type lamin isoforms. Many questions remain, however, concerning the structure and assembly of lamin filaments, as well as with their mode of association with other nuclear components such as peripheral chromatin.

  17. Computation of Phase Equilibrium and Phase Envelopes

    DEFF Research Database (Denmark)

    Ritschel, Tobias Kasper Skovborg; Jørgensen, John Bagterp

    formulate the involved equations in terms of the fugacity coefficients. We present expressions for the first-order derivatives. Such derivatives are necessary in computationally efficient gradient-based methods for solving the vapor-liquid equilibrium equations and for computing phase envelopes. Finally, we......In this technical report, we describe the computation of phase equilibrium and phase envelopes based on expressions for the fugacity coefficients. We derive those expressions from the residual Gibbs energy. We consider 1) ideal gases and liquids modeled with correlations from the DIPPR database...... and 2) nonideal gases and liquids modeled with cubic equations of state. Next, we derive the equilibrium conditions for an isothermal-isobaric (constant temperature, constant pressure) vapor-liquid equilibrium process (PT flash), and we present a method for the computation of phase envelopes. We...

  18. Boundaries, injective envelopes, and reduced crossed products

    DEFF Research Database (Denmark)

    Bryder, Rasmus Sylvester

    In this dissertation, we study boundary actions, equivariant injective envelopes, as well as theideal structure of reduced crossed products. These topics have recently been linked to thestudy of C-simple groups, that is, groups with simple reduced group C-algebras.In joint work with Matthew Kennedy......, we consider reduced twisted crossed products overC-simple groups. For any twisted C-dynamical system over a C-simple group, we provethat there is a one-to-one correspondence between maximal invariant ideals in the underlyingC-algebra and maximal ideals in the reduced crossed product. When......*-algebras, and relate the intersection property for group actions on unital C*-algebras to the intersection property for theequivariant injective envelope. Moreover, we also prove that the equivariant injective envelopeof the centre of the injective envelope of a unital C*-algebra can be regarded as a C...

  19. Nuclear

    International Nuclear Information System (INIS)

    2014-01-01

    This document proposes a presentation and discussion of the main notions, issues, principles, or characteristics related to nuclear energy: radioactivity (presence in the environment, explanation, measurement, periods and activities, low doses, applications), fuel cycle (front end, mining and ore concentration, refining and conversion, fuel fabrication, in the reactor, back end with reprocessing and recycling, transport), the future of the thorium-based fuel cycle (motivations, benefits and drawbacks), nuclear reactors (principles of fission reactors, reactor types, PWR reactors, BWR, heavy-water reactor, high temperature reactor of HTR, future reactors), nuclear wastes (classification, packaging and storage, legal aspects, vitrification, choice of a deep storage option, quantities and costs, foreign practices), radioactive releases of nuclear installations (main released radio-elements, radioactive releases by nuclear reactors and by La Hague plant, gaseous and liquid effluents, impact of releases, regulation), the OSPAR Convention, management and safety of nuclear activities (from control to quality insurance, to quality management and to sustainable development), national safety bodies (mission, means, organisation and activities of ASN, IRSN, HCTISN), international bodies, nuclear and medicine (applications of radioactivity, medical imagery, radiotherapy, doses in nuclear medicine, implementation, the accident in Epinal), nuclear and R and D (past R and D programmes and expenses, main actors in France and present funding, main R and D axis, international cooperation)

  20. A study of some Be star envelopes

    International Nuclear Information System (INIS)

    Kitchen, C.R.

    1976-01-01

    The envelope model and emission region radius of six Be stars have been determined from 36 lines on 15 spectra taken with the Isaac Newton telescope. The results have been compared with earlier determinations to search for changes with the time. No definite evidence for such changes has been found, although there may be an indication of a change in phi Per. A re-determination of the errors involved in the method of analysis shows that these are smaller than previously estimated and range from about 9% to 35% for both envelope model and emission region radius. (Auth.)

  1. Asymmetry of the SN 1987A envelope

    International Nuclear Information System (INIS)

    Chugaj, N.N.

    1991-01-01

    The origin of the peculiar structure in the profiles of the emission lines observed in the spectrum of SN 1987A, namely, (1) redshift of maxima, and (2) fine structure of hydrogen lines, is considered. Among the three proposed hypothesis for the redshift, at least two (electron scattering in the spherically-symmetric envelope, and geometrical effects in the fragmented envelope) have serious drawbacks. More favorable is the third hypothesis which invokes asymmetric distribution of 56 Ni and of the iron-peak elements

  2. Radio Imaging of Envelopes of Evolved Stars

    Science.gov (United States)

    Cotton, Bill

    2018-04-01

    This talk will cover imaging of stellar envelopes using radio VLBI techniques; special attention will be paid to the technical differences between radio and optical/IR interferomery. Radio heterodyne receivers allow a straightforward way to derive spectral cubes and full polarization observations. Milliarcsecond resolution of very bright, i.e. non thermal, emission of molecular masers in the envelopes of evolved stars can be achieved using VLBI techniques with baselines of thousands of km. Emission from SiO, H2O and OH masers are commonly seen at increasing distance from the photosphere. The very narrow maser lines allow accurate measurements of the velocity field within the emitting region.

  3. Global Envelope Tests for Spatial Processes

    DEFF Research Database (Denmark)

    Myllymäki, Mari; Mrkvička, Tomáš; Grabarnik, Pavel

    2017-01-01

    Envelope tests are a popular tool in spatial statistics, where they are used in goodness-of-fit testing. These tests graphically compare an empirical function T(r) with its simulated counterparts from the null model. However, the type I error probability α is conventionally controlled for a fixed d......) the construction of envelopes for a deviation test. These new tests allow the a priori selection of the global α and they yield p-values. We illustrate these tests using simulated and real point pattern data....

  4. Global envelope tests for spatial processes

    DEFF Research Database (Denmark)

    Myllymäki, Mari; Mrkvička, Tomáš; Grabarnik, Pavel

    Envelope tests are a popular tool in spatial statistics, where they are used in goodness-of-fit testing. These tests graphically compare an empirical function T(r) with its simulated counterparts from the null model. However, the type I error probability α is conventionally controlled for a fixed......) the construction of envelopes for a deviation test. These new tests allow the a priori selection of the global α and they yield p-values. We illustrate these tests using simulated and real point pattern data....

  5. Nucleated regeneration of semiarid sclerophyllous forests close to remnant vegetation

    NARCIS (Netherlands)

    Fuentes-Castillo, T.; Miranda, A.; Rivera-Hutinel, A.; Smith-Ramirez, C.; Holmgren, M.

    2012-01-01

    Natural regeneration of mediterranean plant communities has proved difficult in all continents. In this paper we assess whether regeneration of sclerophyllous forests shows nucleated patterns indicative of a positive effect of vegetation remnants at the landscape level and compare the regeneration

  6. X-Ray Emission Properties of Supernova Remnants

    NARCIS (Netherlands)

    Vink, J.; Alsabti, A.W.; Murdin, P.

    2016-01-01

    X-ray emission from supernova remnants can be broadly divided into thermal X-ray emission from the shock-heated plasmas and in nonthermal (synchrotron) emission caused by very high-energy (10–100 TeV) electrons moving in the magnetic fields of the hot plasmas. The thermal X-ray emission of young

  7. Supernova remnants, pulsar wind nebulae and their interaction

    NARCIS (Netherlands)

    Swaluw, E. van der

    2001-01-01

    A supernova explosion marks the end of the evolution of a massive star. What remains of the exploded star is a high density neutron star or a black hole. The material which has been ejected by the supernova explosion will manifest itself as a supernova remnant: a hot bubble of gas expanding in the

  8. The origin of radio recombination lines seen toward supernova remnants

    International Nuclear Information System (INIS)

    Pankonin, V.; Downes, D.

    1976-01-01

    New observations have been made of the 166 α spectrum in the direction of the supernova remnants G-0.6 - 0.1, 3 C 391 and W 49 B. The variation of the intensity of the hydrogen recombination lines with frequency indicates that the lines arise in extended, low-density H II regions and not in cold clouds. (orig.) [de

  9. Efficacy of different I-131 doses for thyroid remnant ablation

    International Nuclear Information System (INIS)

    Nguyen, X.C.; Thiep, T.V.; Hung, N.C.

    2007-01-01

    Full text: Radioactive iodine 131 I has been widely used as a treatment modality of differentiated thyroid carcinoma. The need for high dose radioiodine ablation of thyroid remnant is still in question. The aim of this prospective study was to assess the efficacy of 131 I different single and fractionated doses in ablation of post-operative thyroid remnant. Patients and methods: One hundred-twelve patients were included in this study. Sixty-one patients with TSH≥30 μU/ml were treated 30 mCi in group 1 (36 patients) or 100 mCi in group 2 (25 patients). Fifty one patients with TSH 131 I high dose of 100 mCi and no severe adverse effect in the other groups. Conclusion: Single high dose (100 mCi) may be more efficient than single low dose (30 mCi) for post-operative remnant ablation with serum TSH≥30 μU/ml and the efficacy of low fractionated doses (30+30 mCi) was comparable with high-fractionated dose (30+100 mCi) for post-operative remnant ablation with low serum TSH in differentiated thyroid carcinoma. (author)

  10. CASE REPORT Urachal remnant carcinoma - a rare entity

    African Journals Online (AJOL)

    Magnetic resonance imaging (MRI) was not undertaken as it was thought to confer little benefit in the setting of advanced disease. Following histological confirmation of moderately differentiated invasive adenocarcinoma of the urachal remnant, and administration of chemotherapy, the patient developed cerebral metastasis ...

  11. Bat use of remnant old-growth redwood stands

    Science.gov (United States)

    William J. Zielinski; Steven T. Gellman

    1999-01-01

    Most of the old-growth redwood (Sequoia sempervirens) in Calfornia has been cut; regenerating forests will probably never resemble those that were harvested, and what old growth remains on private land occurs in small, isolated remnant patches. The landscapes in which these stands occur differ so markedly from their original condition that their...

  12. Constraining the number of compact remnants near Sgr A*

    Science.gov (United States)

    Deegan, Patrick; Nayakshin, Sergei

    2007-05-01

    Due to dynamical friction stellar mass black holes and neutron stars are expected to form high-density cusps in the inner parsec of our Galaxy. These compact remnants, expected to number around 20000, may be accreting cold dense gas present there, and give rise to potentially observable X-ray emission. Here we build a simple but detailed time-dependent model of such emission. The possibility that these accretion flows are radiatively inefficient is taken into account and brings in some uncertainty in the conclusions. Despite this uncertainty, we find that at least several X-ray sources of this nature should be detectable with Chandra at any one time. Turning this issue around, we also ask a question of what current observational constraints might be telling us about the total number of compact remnants. In our `best guess' model, a cusp of ~40000 remnants overpredicts the number of discrete sources and the total X-ray luminosity of the inner parsec, and is hence ruled out. In the most radiatively inefficient scenario that we consider, the radiative efficiency is set to be as small as ɛ = 10-5. In this rather unlikely scenario, a cusp of ~40000 black holes would be allowed by the data, but several individual sources should still be visible. Future observations of the distribution and orbits of the cold ionized gas in the inner parsec of our Galaxy will put tighter constraints on the cusp of compact remnants.

  13. On The Origin Of Two-Shell Supernova Remnants

    Science.gov (United States)

    Gvaramadze, Vasilii

    2007-07-01

    The proper motion of massive stars could cause them to explode far from the geometric centers of their wind-driven bubbles and thereby could affect the symmetry of the resulting diffuse supernova remnants (SNRs). We use this fact to explain the origin of SNRs consisting of two partially overlapping shells (e.g. Cygnus Loop, 3C 400.2, etc.).

  14. A Recurrent Nova Super-Remnant in the Andromeda Galaxy

    DEFF Research Database (Denmark)

    Darnley, M. J.; Hounsell, R.; O'Brien, T. J.

    2017-01-01

    Here we report that the most rapidly recurring nova, M31N 2008-12a, which erupts annually, is surrounded by a "nova super-remnant" which demonstrates that M31N 2008-12a has erupted with high frequency for millions of years....

  15. Cervical chondrocutaneous branchial remnants--report of 17 cases.

    Science.gov (United States)

    Begovic, Ninoslav; Simic, Radoje; Vlahovic, Aleksandar; Kravljanac, Djordje; Djuricic, Slavisa; Mijovic, Tanja

    2014-11-01

    Cervical chondrocutaneous branchial remnants are congenital, benign and rare neck masses. These anomalies are limited in the literature, reported mostly as case reports. Cervical chondrocutaneous branchial remnant is always present at birth, and the lesion is usually unilateral. Understanding and treatment of cervical chondrocutaneous branchial remnants requires knowledge of the related embryology. From January 2005 to December 2008, 17 patients with mean age of 32 months (range from 2 months to 15 years) with CCBRs were treated at the Division of Pediatric Surgery, Department of Plastic and Reconstructive Surgery and Burns at the Institute for Mother and Child Health Care, Belgrade, Serbia. The following objections were recorded: sex, lesion side, surgical data, associated malformations and pathohistology findings. There were 7 females and 10 males, 4 with bilateral presences. Five children had associated anomalies, as follows: vesicoureteral reflux, atrial and ventricular septal defect, ventricular septal defect, branchiootorenal syndrome and preauricular sinus. There was a positive family history in one patient. Fifteen patients (88%) were treated with complete surgical excision and no connections with deep underlying structures of the neck were found. There were no complications at surgery. No recurrence was found during follow-up. Histopathology analysis revealed both, hyaline and elastic cartilage. Cervical chondrocutaneous branchial remnants are rare anomalies arising from branchial arch, probably originally from remnants of first or second arch. Surgical excision is the treatment of choice. From our experience, we suggest surgical treatment early in childhood because of esthetic reason, simplicity of the intervention and low complication rate. Also, the abdominal ultrasound and cardiac examination is recommended because of associated anomalies. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  16. Hot interstellar tunnels. I. Simulation of interacting supernova remnants

    International Nuclear Information System (INIS)

    Smith, B.W.

    1977-01-01

    Reexamining a suggestion of Cox and Smith, we find that intersecting supernova remnants can indeed generate and maintain hot interstellar regions with napproximately-less-than10 -2 cm -3 and Tapprox.10 6 K. These regions are likely to occupy at least 30% of the volume of a spiral arm near the midplane of the gaseous disk if the local supernova rate there is greater than 1.5 x 10 -7 Myr -1 pc -3 . Their presence in the interstellar medium is supported by observations of the soft X-ray background. The theory required to build a numerical simulation of interacting supernova remnants is developed. The hot cavities within a population of remnants will become connected for a variety of assumed conditions in the outer shells of old remnants. Extensive hot cavity regions or tunnels are built and enlarged by supernovae occurring in relatively dense gas which produce connections, but tunnels are kept hot primarily by supernovae occurring within the tunnels. The latter supernovae initiate fast shock waves which apparently reheat tunnels faster than they are destroyed by thermal conduction in a galactic magnetic field or by radiative cooling. However, the dispersal of these rejuvenating shocks over a wide volume is inhibited by motions of cooler interstellar gas in the interval between shocks. These motions disrupt the contiguity of the component cavities of a tunnel and may cause its death.The Monte Carlo simulations indicate that a quasi-equilibrium is reached within 10 7 years of the first supernova in a spiral arm. This equilibrium is characterized by a constant average filling fraction for cavities in the interstellar volume. Aspects of the equilibrium are discussed for a range of supernova rates. Two predictions of Cox and Smith are not confirmed within this range: critical growth of hot regions to encompass the entire medium, and the efficient quenching of a remnant's expansion by interaction with other cavities

  17. X-ray surface brightness of Kepler's supernova remnant

    International Nuclear Information System (INIS)

    White, R.L.; Long, K.S.

    1983-01-01

    We have observed Kepler's supernova remnant (SNR) with the imaging instruments on board the Einstein Observatory. The 0.15-4.5 keV flux incident on the Earth is 1.2 x 10 - 10 ergs cm - 2 s - 1 ; the flux corrected for interstellar absorption is 3.4 x 10 - 10 ergs cm - 2 s - 1 (L/sub x/ = 1.0 x 10 36 ergs s - 1 at D = 5 kpc) if the absorbing column density is N/sub H/ = 2.8 x 10 21 cm - 2 . The remnant is circular and shows a strong shell which is at least 5 times brighter in the north than in the south. The X-ray observations do not unambiguously determine whether the remnant is in the adiabatic or the free expansion phase. If the remnant is in the adiabatic phase, the density of the interstellar medium (ISM) ( 2 /sub e/>/sup 1/2/) surrounding Kepler's SNR must be about 5 cm - 3 . If the remnant is in the free expansion phase, where most of the emission arises from shock-heated ejecta, the ISM density must still be relatively high, n/sub i/> or approx. =0.1 cm - 3 . Even if the ISM is very inhomogeneous, with very many small, dense clouds, we show that the mean density of the ISM must be greater than approx.0.1 cm - 3 . In any case, the density of the x-ray emitting gas must be high ( 2 /sub e/>/sup 1/2/ > or approx. =10 cm - 3 ), and the temperature must be fairly low (T/sub e/ 7 K). The relatively high ISM density which is required is surprising in view of Kepler's distance above the galactic plane, approx.600 pc. Possibly the ISM around Kepler's SNR and around other type i SNRs is dominated by the mass lost from the presupernova star

  18. Integrated Energy Design of the Building Envelope

    DEFF Research Database (Denmark)

    Nielsen, Martin Vraa

    This thesis describes the outcome of the PhD project Integrated energy design of the building envelope carried out through a combination of scientific dissemination reported through peer-reviewed journals and a wide range of affiliated projects involved in at an architectural firm. The research...

  19. Multi-layered breathing architectural envelope

    DEFF Research Database (Denmark)

    Lund Larsen, Andreas; Foged, Isak Worre; Jensen, Rasmus Lund

    2014-01-01

    A multi layered breathing envelope is developed as a method of natural ventilation. The two main layers consist of mineral wool and air permeable concrete. The mineral wool works as a dynamic insulation and the permeable concrete as a heat recovery system with a high thermal mass for heat storage...

  20. Cost Allocation and Convex Data Envelopment

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Tind, Jørgen

    such as Data Envelopment Analysis (DEA). The convexity constraint of the BCC model introduces a non-zero slack in the objective function of the multiplier problem and we show that the cost allocation rules discussed in this paper can be used as candidates to allocate this slack value on to the input (or output...

  1. Moisture accumulation in a building envelope

    Energy Technology Data Exchange (ETDEWEB)

    Forest, T.W.; Checkwitch, K.

    1988-09-01

    In a large number of cases, the failure of a building envelope can be traced to the accumulation of moisture. In a cold winter climate, characteristic of the Canadian prairies, moisture is deposited in the structure by the movement of warm, moist air through the envelope. Tests on the moisture accumulation in a building envelope were initiated in a test house at an Alberta research facility during the 1987/88 heating season. The indoor moisture generation rate was measured and compared with the value inferred from the measured air infiltration rate. With the flue open, the moisture generation rate was approximately 5.5 kg/d of which 0.7 kg/d entered the building envelope; the remainder was exhausted through the flue. With the flue blocked, the moisture generation rate decreased to 3.4 kg/d, while the amount of moisture migrating through the envelope increased to 4.0 kg/d. The moisture accumulation in wall panels located on the north and south face of the test house was also monitored. Moisture was allowed to enter the wall cavity via a hole in the drywall. The fiberglass insulation remained dry throughout the test period. The moisture content of the exterior sheathing of the north panel increased to a maximum of 18% wt in the vicinity of the hole, but quickly dried when the ambient temperatures increased towards the end of the season. The south panel showed very little moisture accumlation due to the effects of solar radiation. 14 refs., 9 figs.

  2. Validating predictions from climate envelope models.

    Directory of Open Access Journals (Sweden)

    James I Watling

    Full Text Available Climate envelope models are a potentially important conservation tool, but their ability to accurately forecast species' distributional shifts using independent survey data has not been fully evaluated. We created climate envelope models for 12 species of North American breeding birds previously shown to have experienced poleward range shifts. For each species, we evaluated three different approaches to climate envelope modeling that differed in the way they treated climate-induced range expansion and contraction, using random forests and maximum entropy modeling algorithms. All models were calibrated using occurrence data from 1967-1971 (t1 and evaluated using occurrence data from 1998-2002 (t2. Model sensitivity (the ability to correctly classify species presences was greater using the maximum entropy algorithm than the random forest algorithm. Although sensitivity did not differ significantly among approaches, for many species, sensitivity was maximized using a hybrid approach that assumed range expansion, but not contraction, in t2. Species for which the hybrid approach resulted in the greatest improvement in sensitivity have been reported from more land cover types than species for which there was little difference in sensitivity between hybrid and dynamic approaches, suggesting that habitat generalists may be buffered somewhat against climate-induced range contractions. Specificity (the ability to correctly classify species absences was maximized using the random forest algorithm and was lowest using the hybrid approach. Overall, our results suggest cautious optimism for the use of climate envelope models to forecast range shifts, but also underscore the importance of considering non-climate drivers of species range limits. The use of alternative climate envelope models that make different assumptions about range expansion and contraction is a new and potentially useful way to help inform our understanding of climate change effects on

  3. Validating predictions from climate envelope models

    Science.gov (United States)

    Watling, J.; Bucklin, D.; Speroterra, C.; Brandt, L.; Cabal, C.; Romañach, Stephanie S.; Mazzotti, Frank J.

    2013-01-01

    Climate envelope models are a potentially important conservation tool, but their ability to accurately forecast species’ distributional shifts using independent survey data has not been fully evaluated. We created climate envelope models for 12 species of North American breeding birds previously shown to have experienced poleward range shifts. For each species, we evaluated three different approaches to climate envelope modeling that differed in the way they treated climate-induced range expansion and contraction, using random forests and maximum entropy modeling algorithms. All models were calibrated using occurrence data from 1967–1971 (t1) and evaluated using occurrence data from 1998–2002 (t2). Model sensitivity (the ability to correctly classify species presences) was greater using the maximum entropy algorithm than the random forest algorithm. Although sensitivity did not differ significantly among approaches, for many species, sensitivity was maximized using a hybrid approach that assumed range expansion, but not contraction, in t2. Species for which the hybrid approach resulted in the greatest improvement in sensitivity have been reported from more land cover types than species for which there was little difference in sensitivity between hybrid and dynamic approaches, suggesting that habitat generalists may be buffered somewhat against climate-induced range contractions. Specificity (the ability to correctly classify species absences) was maximized using the random forest algorithm and was lowest using the hybrid approach. Overall, our results suggest cautious optimism for the use of climate envelope models to forecast range shifts, but also underscore the importance of considering non-climate drivers of species range limits. The use of alternative climate envelope models that make different assumptions about range expansion and contraction is a new and potentially useful way to help inform our understanding of climate change effects on species.

  4. Novel Real-Time Flight Envelope Monitoring System, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed innovation is an aircraft flight envelope monitoring system that will provide real-time in-cockpit estimations of aircraft flight envelope boundaries....

  5. Contribution of infrared observations to the study of supernovae remnants

    International Nuclear Information System (INIS)

    Douvion, Thomas

    2000-01-01

    This research thesis addresses the study of dust in young supernovae remnants observed in middle infrared, mainly by means of the ISOCAM instrument installed on the ISO satellite. The author first presents the supernovae physics and the studied young remnants, describes dusts and the main sites of formation and destruction, and outlines the difficulties and benefits of observations performed in the middle infrared. Then, the author reports acquired evidences related to the formation of dusts in supernovae, and the search for a millimetre emission by cold dust contained in regions which are not yet excited by the shock, in order to better assess the overall quantities created by supernovae. He reports the use of observations of dust and neon in Cassiopeia A to perform a diagnosis on the mixture of elements during the supernovae explosion [fr

  6. The population of supernova remnants in the Magellanic Clouds

    CERN Document Server

    Dennefeld, M

    1978-01-01

    The detection of SNRs in the Magellanic Clouds is reviewed with emphasis on its limits. A sample of SNRs is then used to derive the mean interval between SN explosions, tau . After the maximum constraints have been put on all the other parameters, the distribution of diameters of remnants with diameter less than 30 pc in the LMC is shown to agree well with theoretical predictions. In adopting a mean value of E/sub 0//n/sub 0/ (energy at explosion over surrounding density) of 5*10/sup 51/ ergs cm/sup 3/, the best value of tau is 300+or-100 years in good agreement with predictions from statistics of supernovae in external galaxies. The small number of remnants in the SMC prevents a similar approach being used with any statistical significance. (20 refs).

  7. Dynamics of supernova remnants in the Galactic centre.

    Science.gov (United States)

    Bortolas, E.; Mapelli, M.; Spera, M.

    The Galactic centre (GC) is a unique place to study the extreme dynamical processes occurring near a super-massive black hole (SMBH). Here we simulate a large set of binaries orbiting the SMBH while the primary member undergoes a supernova (SN) explosion, in order to study the impact of SN kicks on the orbits of stars and dark remnants in the GC. We find that SN explosions are efficient in scattering neutron stars and other light stars on new (mostly eccentric) orbits, while black holes (BHs) tend to retain memory of the orbit of their progenitor star. SN kicks are thus unable to eject BHs from the GC: a cusp of dark remnants may be lurking in the central parsec of our Galaxy.

  8. Intestinal obstruction caused by omphalomesenteric duct remnant: usefulness of laparoscopy.

    Science.gov (United States)

    Bueno Lledó, J; Serralta Serra, A; Planeéis Roig, M; Dobón Giménez, F; Ibáñez Palacín, F; Rodero Rodero, R

    2003-10-01

    The anomalies related to omphalomesenteric duct remnant constitute an uncommon cause of intestinal obstruction, of which Meckel"s diverticulum and its variants represent the most important clinical presentation. In most cases they are asymptomatic and usually affect young patients. When symptomatic, they usually present episodes of gastrointestinal bleeding or acute abdomen syndromes caused by strangulation of intestinal loops as a result of fibrous intraabdominal remnants or inflammation produced by the diverticulum. In most cases, the unexpected presence of these alterations makes intraoperative diagnosis necessary. Treatment is surgical and consists in exeresis of the diverticulum or the fibrous band causing the clinical picture. We report two cases of persistence of the vitelline duct resolved by laparoscopic approach.

  9. Confinement of the crab pulsar's wind by its supernova remnant

    International Nuclear Information System (INIS)

    Kennel, C.F.; Coroniti, F.V.

    1984-01-01

    We construct a steady state, spherically symmetric, magnetohydrodynamic model of the Crab nebual. A highly relativistic, positronic pulsar wind is terminated by a strong MHD shock that decelerates the flow and increases its pressure to match boundary conditions imposed by the recently discovered supernova remnant that surrounds the nebula. If the magnetic luminosity of the pulsar wind upsteam of the shock is about 0.3% of its particle luminosity, the pressure and velocity boundary conditions imposed by the remnant place the shock where we infer it to be; near the outer boundary of an underluminous region observed to surround the pulsar. It is necessary to include the weak magnetization of the wind to satisfy the boundary conditions and to calculate the nebular synchrotron radiation self-consistently

  10. The optical emission from the supernova remnant HB 3

    Science.gov (United States)

    Fesen, R. A.; Gull, T. R.

    1983-01-01

    The supernova remnant HB 3 was first detected as a radio source by Brown and Hazard (1953). On the basis of subsequent radio studies, it was concluded that the object was a supernova remnant (SNR). HB 3 is located at the far western edge of the H II region/molecular cloud complex W3-W4-W5 (IC 1795-1805-1848). However, a physical association of HB 3 with this complex is uncertain. In the present investigation, attention is called to the probability that HB 3 exhibits a more extensive optical emission structure than previously realized, and one which agrees well with both the position and morphology of the radio emission. It is found that narrow-passband optical images strongly suggest an almost complete optical emission shell for HB 3. Spectroscopic observations are, however, required to confirm that this emission is characteristic of a SNR.

  11. Inversion of Auditory Spectrograms, Traditional Spectrograms, and Other Envelope Representations

    DEFF Research Database (Denmark)

    Decorsière, Remi Julien Blaise; Søndergaard, Peter Lempel; MacDonald, Ewen

    2015-01-01

    Envelope representations such as the auditory or traditional spectrogram can be defined by the set of envelopes from the outputs of a filterbank. Common envelope extraction methods discard information regarding the fast fluctuations, or phase, of the signal. Thus, it is difficult to invert, or re...... to the framework is proposed, which leads to a more accurate inversion of traditional spectrograms...

  12. 200 Area Deactivation Project Facilities Authorization Envelope Document

    International Nuclear Information System (INIS)

    DODD, E.N.

    2000-01-01

    Project facilities as required by HNF-PRO-2701, Authorization Envelope and Authorization Agreement. The Authorization Agreements (AA's) do not identify the specific set of environmental safety and health requirements that are applicable to the facility. Therefore, the facility Authorization Envelopes are defined here to identify the applicable requirements. This document identifies the authorization envelopes for the 200 Area Deactivation

  13. 14 CFR 27.87 - Height-speed envelope.

    Science.gov (United States)

    2010-01-01

    ... applicable power failure condition in paragraph (b) of this section, a limiting height-speed envelope must be... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Height-speed envelope. 27.87 Section 27.87... STANDARDS: NORMAL CATEGORY ROTORCRAFT Flight Performance § 27.87 Height-speed envelope. (a) If there is any...

  14. 14 CFR 29.87 - Height-velocity envelope.

    Science.gov (United States)

    2010-01-01

    ... Category A engine isolation requirements, the height-velocity envelope for complete power failure must be... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Height-velocity envelope. 29.87 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Flight Performance § 29.87 Height-velocity envelope. (a...

  15. Analysis of Building Envelope Construction in 2003 CBECS

    Energy Technology Data Exchange (ETDEWEB)

    Winiarski, David W.; Halverson, Mark A.; Jiang, Wei

    2007-06-01

    The purpose of this analysis is to determine "typical" building envelope characteristics for buildings built after 1980. We address three envelope components in this paper - roofs, walls, and window area. These typical building envelope characteristics were used in the development of DOE’s Reference Buildings .

  16. Chandra Observations of Tycho's Supernova Remnant U. Hwang , R ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    runaway thermal instabilities in a white dwarf. It was observed for 50 ks with the superb 0.5 resolution mirror on the Chandra X-ray .... emission that comes from ejecta that have propagated to the forward shock. Such a spectrum, taken from a portion of the west rim of the remnant, is shown in the right panel of Fig. 2. The fitted ...

  17. Cosmic Ray and Tev Gamma Ray Generation by Quasar Remnants

    Science.gov (United States)

    Boldt, Elihu; Loewenstein, Michael; White, Nicholas E. (Technical Monitor)

    2000-01-01

    Results from new broadband (radio to X-ray) high-resolution imaging studies of the dormant quasar remnant cores of nearby giant elliptical galaxies are now shown to permit the harboring of compact dynamos capable of generating the highest energy cosmic ray particles and associated curvature radiation of TeV photons. Confirmation would imply a global inflow of interstellar gas all the way to the accretion powered supermassive black hole at the center of the host galaxy.

  18. Study of the photon remnant in resolved photoproduction at HERA

    International Nuclear Information System (INIS)

    Derrick, M.; Krakauer, D.; Magill, S.

    1995-01-01

    Photoproduction at HERA is studied in ep collisions, with the ZEUS detector, for γp centre-of-mass energies ranging from 130-270 GeV. A sample of events with two high-p T jets (p T >6 GeV, η T with respect to the beam axis is measured to be 2.1±0.2 GeV, which demonstrates substantial mean transverse momenta for the photon remnant. (orig.)

  19. Time evolution of gamma rays from supernova remnants

    Science.gov (United States)

    Gaggero, Daniele; Zandanel, Fabio; Cristofari, Pierre; Gabici, Stefano

    2018-04-01

    We present a systematic phenomenological study focused on the time evolution of the non-thermal radiation - from radio waves to gamma rays - emitted by typical supernova remnants via hadronic and leptonic mechanisms, for two classes of progenitors: thermonuclear and core-collapse. To this aim, we develop a numerical tool designed to model the evolution of the cosmic ray spectrum inside a supernova remnant, and compute the associated multi-wavelength emission. We demonstrate the potential of this tool in the context of future population studies based on large collection of high-energy gamma-ray data. We discuss and explore the relevant parameter space involved in the problem, and focus in particular on their impact on the maximum energy of accelerated particles, in order to study the effectiveness and duration of the PeVatron phase. We outline the crucial role of the ambient medium through which the shock propagates during the remnant evolution. In particular, we point out the role of dense clumps in creating a significant hardening in the hadronic gamma-ray spectrum.

  20. Search for Nonthermal X-Rays from Supernova Remnant Shells

    Science.gov (United States)

    Petre, R.; Keohane, J.; Hwang, U.; Allen, G.; Gotthelf, E.

    The demonstration by ASCA that the nonthermal X-ray emission from the rim of SN1006 is synchrotron emission from TeV electrons, produced in the same environment responsible for cosmic ray protons and nuclei (Koyama et al. 1995, Nature 378, 255), has stimulated a search for nonthermal X-rays from other remnants. Nonthermal emission has subsequently been found to arise in the shells of at least two other remnants, Cas A and IC 443. In Cas A, a hard tail is detected using ASCA, XTE, and OSSE to energies exceeding 100 keV; the shape of the spectrum rules out all mechanisms except synchrotron radiation. In IC 443, the previously known hard emission has been shown using ASCA to be isolated to a small region along the rim of the remnant, where the shock is interacting most strongly with a molecular cloud. Nonthermal X-ray emission is thought to arise here by enhanced cosmic ray production associated with the shock/cloud interaction (Keohane et al. 1997, ApJ in press). We describe the properties of the nonthermal emission in SN1006, Cas A, and IC 443, and discuss the status of our search for nonthermal emission associated with the shocks of other Galactic and LMC SNR's.

  1. CORRELATION OF SUPERNOVA REMNANT MASERS AND GAMMA-RAY SOURCES

    International Nuclear Information System (INIS)

    Hewitt, John W.; Yusef-Zadeh, Farhad; Wardle, Mark

    2009-01-01

    Supernova remnants (SNRs) interacting with molecular clouds are potentially exciting systems in which to detect evidence of cosmic ray acceleration. Prominent γ-ray emission is produced via the decay of neutral pions when cosmic rays encounter nearby dense clouds. In many of the SNRs coincident with γ-ray sources, the presence of OH (1720 MHz) masers is used to identify interaction with dense gas and to provide a kinematic distance to the system. In this Letter we use statistical tests to demonstrate that there is a correlation between these masers and a class of GeV- to TeV-energy γ-ray sources coincident with interacting remnants. For pion decay the γ-ray luminosity provides a direct estimate of the local cosmic ray density. We find the cosmic ray density is enhanced by one to two orders of magnitude over the local solar value, comparable to X-ray-induced ionization in these remnants. The inferred ionization rates are sufficient to explain non-equilibrium chemistry in the post-shock gas, where high columns of hydroxyl are observed.

  2. Current status in remnant gastric cancer after distal gastrectomy

    Science.gov (United States)

    Ohira, Masaichi; Toyokawa, Takahiro; Sakurai, Katsunobu; Kubo, Naoshi; Tanaka, Hiroaki; Muguruma, Kazuya; Yashiro, Masakazu; Onoda, Naoyoshi; Hirakawa, Kosei

    2016-01-01

    Remnant gastric cancer (RGC) and gastric stump cancer after distal gastrectomy (DG) are recognized as the same clinical entity. In this review, the current knowledges as well as the non-settled issues of RGC are presented. Duodenogastric reflux and denervation of the gastric mucosa are considered as the two main factors responsible for the development of RGC after benign disease. On the other hand, some precancerous circumstances which already have existed at the time of initial surgery, such as atrophic gastritis and intestinal metaplasia, are the main factors associated with RGC after gastric cancer. Although eradication of Helicobacter pylori (H. pylori) in remnant stomach is promising, it is still uncertain whether it can reduce the risk of carcinogenesis. Periodic endoscopic surveillance after DG was reported useful in detecting RGC at an early stage, which offers a chance to undergo minimally invasive endoscopic treatment or laparoscopic surgery and leads to an improved prognosis in RGC patients. Future challenges may be expected to elucidate the benefit of eradication of H. pylori in the remnant stomach if it could reduce the risk for RGC, to build an optimal endoscopic surveillance strategy after DG by stratifying the risk for development of RGC, and to develop a specific staging system for RGC for the standardization of the treatment by prospecting the prognosis. PMID:26937131

  3. Are young supernova remnants interacting with circumstellar gas

    International Nuclear Information System (INIS)

    Chevalier, R.A.

    1982-01-01

    The young remnants of galactic Type I supernovae (SN 1006, SN 1572, and SN 1604) appear to be interacting with moderately dense gas (n/sub O/> or =0.1 cm -3 ). If the gas in the ambient interstellar medium, the observations suggest that gas of this density is fairly pervasive. If the gas is circumstellar, there are important implications for the progenitors of Type I supernovae. A plausible density distribution for circumstellar gas is rhoinfinityr -2 . The expansion of a supernova into such a medium is examined and is compared with expansion into a uniform medium. The two cases can be distinguished on the basis of their density profiles and their rates of expansion. Currently available data factor the hypothesis of expansion in a uniform medium for all three Type I remnants; the evidence is the strongest for SN 1572 and the weakest for SN 1604. Further X-ray and radio observations of the galactic remnants and of extragalactic Type I supernovae should serve to test this hypothesis

  4. Modelling neutrino and gamma-ray fluxes in supernova remnants

    International Nuclear Information System (INIS)

    Ballet, J; Cassam-Chenai, G; Maurin, G; Naumann, C

    2008-01-01

    Supernova remnants (SNRs) are believed to accelerate charged particles by diffusive shock acceleration (DSA) and to produce the majority of galactic cosmic rays, at least up to the 'knee' at 3-10 15 electron volts. In the framework of a hydrodynamic self-similar simulation of the evolution of young supernova remnants, its interaction with the ambient matter as well as the microwave and infrared background is studied. The photon spectra resulting from synchrotron and inverse Compton emission as well as from hadronic processes are calculated, as are the accompanying neutrino fluxes. Applying this method to the particular case of the SNR RXJ-1713, 7-3946, we find that its TeV emission can in principle be explained by pion decay if the ambient density is assumed to grow with increasing distance from the centre. The neutrino flux associated with this hadronic model is of a magnitude that may be detectable by a cubic-kilometre sized deep-sea neutrino telescope in the northern hemisphere. In this poster, a description of the supernova remnant simulation is given together with the results concerning RXJ-1713.

  5. Phytochrome regulates GTP-binding protein activity in the envelope of pea nuclei

    Science.gov (United States)

    Clark, G. B.; Memon, A. R.; Thompson, G. A. Jr; Roux, S. J.

    1993-01-01

    Three GTP-binding proteins with apparent molecular masses of 27, 28 and 30 kDa have been detected in isolated nuclei of etiolated pea plumules. After LDS-PAGE and transfer to nitrocellulose these proteins bind [32P]GTP in the presence of excess ATP, suggesting that they are monomeric G proteins. When nuclei are disrupted, three proteins co-purify with the nuclear envelope fraction and are highly enriched in this fraction. The level of [32P]GTP-binding for all three protein bands is significantly increased when harvested pea plumules are irradiated by red light, and this effect is reversed by far-red light. The results indicate that GTP-binding activity associated with the nuclear envelope of plant cells is photoreversibly regulated by the pigment phytochrome.

  6. Equivariant calculus in the differential envelope

    International Nuclear Information System (INIS)

    Kastler, D.

    1991-01-01

    The author shows how Z/2-graded cyclic cohomology is related to the equivariant calculus of S. Klimek, W. Kondracki, and A. Lesniewski (HUTMP 90/B247 (1990)). He uses the differential envelope of a complex unital differential algebra. After a presentation of fiber-preserved operators on equivariant functions valued in this algebra on a group he considers certain operators on this algebra. Finally he discusses explicitly the case G=Z/2. (HSI)

  7. Equivariant calculus in the differential envelope

    Energy Technology Data Exchange (ETDEWEB)

    Kastler, D. (Centre National de la Recherche Scientifique, 13 - Marseille (France). Centre de Physique Theorique)

    1991-01-01

    The author shows how Z/2-graded cyclic cohomology is related to the equivariant calculus of S. Klimek, W. Kondracki, and A. Lesniewski (HUTMP 90/B247 (1990)). He uses the differential envelope of a complex unital differential algebra. After a presentation of fiber-preserved operators on equivariant functions valued in this algebra on a group he considers certain operators on this algebra. Finally he discusses explicitly the case G=Z/2. (HSI).

  8. Digital image envelope: method and evaluation

    Science.gov (United States)

    Huang, H. K.; Cao, Fei; Zhou, Michael Z.; Mogel, Greg T.; Liu, Brent J.; Zhou, Xiaoqiang

    2003-05-01

    Health data security, characterized in terms of data privacy, authenticity, and integrity, is a vital issue when digital images and other patient information are transmitted through public networks in telehealth applications such as teleradiology. Mandates for ensuring health data security have been extensively discussed (for example The Health Insurance Portability and Accountability Act, HIPAA) and health informatics guidelines (such as the DICOM standard) are beginning to focus on issues of data continue to be published by organizing bodies in healthcare; however, there has not been a systematic method developed to ensure data security in medical imaging Because data privacy and authenticity are often managed primarily with firewall and password protection, we have focused our research and development on data integrity. We have developed a systematic method of ensuring medical image data integrity across public networks using the concept of the digital envelope. When a medical image is generated regardless of the modality, three processes are performed: the image signature is obtained, the DICOM image header is encrypted, and a digital envelope is formed by combining the signature and the encrypted header. The envelope is encrypted and embedded in the original image. This assures the security of both the image and the patient ID. The embedded image is encrypted again and transmitted across the network. The reverse process is performed at the receiving site. The result is two digital signatures, one from the original image before transmission, and second from the image after transmission. If the signatures are identical, there has been no alteration of the image. This paper concentrates in the method and evaluation of the digital image envelope.

  9. The cell envelope glycoconjugates of Mycobacterium tuberculosis

    Science.gov (United States)

    Angala, Shiva Kumar; Belardinelli, Juan Manuel; Huc-Claustre, Emilie; Wheat, William H.; Jackson, Mary

    2015-01-01

    Tuberculosis (TB) remains the second most common cause of death due to a single infectious agent. The cell envelope of Mycobacterium tuberculosis (Mtb), the causative agent of the disease in humans, is a source of unique glycoconjugates and the most distinctive feature of the biology of this organism. It is the basis of much of Mtb pathogenesis and one of the major causes of its intrinsic resistance to chemotherapeutic agents. At the same time, the unique structures of Mtb cell envelope glycoconjugates, their antigenicity and essentiality for mycobacterial growth provide opportunities for drug, vaccine, diagnostic and biomarker development, as clearly illustrated by recent advances in all of these translational aspects. This review focuses on our current understanding of the structure and biogenesis of Mtb glycoconjugates with particular emphasis on one of most intriguing and least understood aspect of the physiology of mycobacteria: the translocation of these complex macromolecules across the different layers of the cell envelope. It further reviews the rather impressive progress made in the last ten years in the discovery and development of novel inhibitors targeting their biogenesis. PMID:24915502

  10. Spectral envelope sensitivity of musical instrument sounds.

    Science.gov (United States)

    Gunawan, David; Sen, D

    2008-01-01

    It is well known that the spectral envelope is a perceptually salient attribute in musical instrument timbre perception. While a number of studies have explored discrimination thresholds for changes to the spectral envelope, the question of how sensitivity varies as a function of center frequency and bandwidth for musical instruments has yet to be addressed. In this paper a two-alternative forced-choice experiment was conducted to observe perceptual sensitivity to modifications made on trumpet, clarinet and viola sounds. The experiment involved attenuating 14 frequency bands for each instrument in order to determine discrimination thresholds as a function of center frequency and bandwidth. The results indicate that perceptual sensitivity is governed by the first few harmonics and sensitivity does not improve when extending the bandwidth any higher. However, sensitivity was found to decrease if changes were made only to the higher frequencies and continued to decrease as the distorted bandwidth was widened. The results are analyzed and discussed with respect to two other spectral envelope discrimination studies in the literature as well as what is predicted from a psychoacoustic model.

  11. Superresolution Microscopy of the Nuclear Envelope and Associated Proteins.

    Science.gov (United States)

    Xie, Wei; Horn, Henning F; Wright, Graham D

    2016-01-01

    Superresolution microscopy is undoubtedly one of the most exciting technologies since the invention of the optical microscope. Capable of nanometer-scale resolution to surpass the diffraction limit and coupled with the versatile labeling techniques available, it is revolutionizing the study of cell biology. Our understanding of the nucleus, the genetic and architectural center of the cell, has gained great advancements through the application of various superresolution microscopy techniques. This chapter describes detailed procedures of multichannel superresolution imaging of the mammalian nucleus, using structured illumination microscopy and single-molecule localization microscopy.

  12. Nuclear

    International Nuclear Information System (INIS)

    Anon.

    2000-01-01

    The first text deals with a new circular concerning the collect of the medicine radioactive wastes, containing radium. This campaign wants to incite people to let go their radioactive wastes (needles, tubes) in order to suppress any danger. The second text presents a decree of the 31 december 1999, relative to the limitations of noise and external risks resulting from the nuclear facilities exploitation: noise, atmospheric pollution, water pollution, wastes management and fire prevention. (A.L.B.)

  13. Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses

    Directory of Open Access Journals (Sweden)

    Wahyu eWulan

    2015-06-01

    Full Text Available Most viruses with non-segmented single stranded RNA genomes complete their life cycle in the cytoplasm of infected cells. However, despite undergoing replication in the cytoplasm, the structural proteins of some of these RNA viruses localize to the nucleus at specific times in the virus life cycle, primarily early in infection. Limited evidence suggests that this enhances successful viral replication by interfering with or inhibiting the host antiviral response. Nucleocapsid proteins of RNA viruses have a well-established, essential cytoplasmic role in virus replication and assembly. Intriguingly, nucleocapsid proteins of some RNA viruses also localize to the nucleus/nucleolus of infected cells. Their nuclear function is less well understood although significant advances have been made in recent years. This review will focus on the nucleocapsid protein of cytoplasmic enveloped RNA viruses, including their localization to the nucleus/nucleolus and function therein. A greater understanding of the nuclear localization of nucleocapsid proteins has the potential to enhance therapeutic strategies as it can be a target for the development of live-attenuated vaccines or antiviral drugs.

  14. Ten years of experience with third and fourth branchial remnants.

    Science.gov (United States)

    Liberman, Moishe; Kay, Saundra; Emil, Sherif; Flageole, Hélène; Nguyen, Luong T; Tewfik, Ted L; Oudjhane, Kamal; Laberge, Jean-Martin

    2002-05-01

    Third and fourth branchial remnants may result in cysts and abscesses that are in close contact with the thyroid gland. These anomalies are rare and often present diagnostic and therapeutic challenges. The charts of patients diagnosed with a branchial anomaly between July 1991 and July 2001 at the Montreal Children's Hospital were reviewed. All cases of third and fourth branchial remnants or pyriform sinus fistulae were identified. Clinical presentation, imaging, treatment, and outcome were recorded. Eight patients with a third or fourth branchial anomaly were identified and ranged in age from birth to 13 years. All anomalies were left sided. Presenting symptoms consisted of an asymptomatic cervical mass (n = 1), an infected mass (n = 5), neonatal respiratory distress (n = 1), and 1 incidental cyst found on magnetic resonance imaging. Ultrasonography was useful in suggesting the diagnosis in 7 cases. Barium swallow was performed in 3 patients with 2 positive results. Pharyngoscopy results showed the internal opening in 2 of 7 patients. A portion of the thyroid gland was resected in 6 patients. One patient has not yet undergone a definitive procedure. There was 1 recurrence in a patient whose pathology did not confirm a branchial remnant. The diagnosis and management of pyriform sinus anomalies are challenging. Ultrasound scan, computed tomography scan, barium swallow, and pharyngoscopy are all useful. The portion of thyroid involved in the fistula must be excised en bloc with the inflammatory mass, and the tract should be ligated at the level of the pharynx to minimize recurrence. Copyright 2002, Elsevier Science (USA). All rights reserved.

  15. Remarks on Remnants by Fermions’ Tunnelling from Black Strings

    Directory of Open Access Journals (Sweden)

    Deyou Chen

    2014-01-01

    Full Text Available Hawking’s calculation is unable to predict the final stage of the black hole evaporation. When effects of quantum gravity are taken into account, there is a minimal observable length. In this paper, we investigate fermions’ tunnelling from the charged and rotating black strings. With the influence of the generalized uncertainty principle, the Hawking temperatures are not only determined by the rings, but also affected by the quantum numbers of the emitted fermions. Quantum gravity corrections slow down the increases of the temperatures, which naturally leads to remnants left in the evaporation.

  16. Radio and X-ray emission from newly born remnants

    International Nuclear Information System (INIS)

    Salvati, M.

    1983-01-01

    Radio and X-ray observations of SN 1979c and SN 1980k offer a unique opportunity of monitoring the transition from supernovae to remnants. By means of the two-frequency radio light curves, the hypothesis that these objects are surrounded by circumstellar matter, originated in a presupernova wind, is tested, and the relevant parameters are derived. Then the absorption-corrected light curves are used to test the various proposed models. SN 1980k appears to be powered by a canonical shock, while SN 1979c is a good plerion candidate. An optical pulsar could still be detected at its location. (Auth.)

  17. Radio and X-ray emission from supernova remnants

    International Nuclear Information System (INIS)

    Asvarova, A.I.; Novruzova, H.I.; Ahmedova, S.I.

    2010-01-01

    In this paper it was studied the statistical correlation between radio and X-ray emissions from shell-type supernova remnants (SNR). The primary aim of this study is to test the model of radio emission of shell-type SNRs presented by one of the authors. Based on this model of radio emission, by using the Monte Carlo techniques we have simulated statistical relations radio - X-ray luminosities (not surface brightnesses) which then were compared with the observations. X-ray emission is assumed to be thermal. To have a uniform statistical material it was used observational data on the SNRs in Magellanic Clouds

  18. A 3D View of a Supernova Remnant

    Science.gov (United States)

    Kohler, Susanna

    2017-06-01

    The outlined regions mark the 57 knots in Tycho selected by the authors for velocity measurements. Magenta regions have redshifted line-of-sight velocities (moving away from us); cyan regions have blueshifted light-of-sight velocities (moving toward us). [Williams et al. 2017]The Tycho supernova remnant was first observed in the year 1572. Nearly 450 years later, astronomers have now used X-ray observations of Tycho to build the first-ever 3D map of a Type Ia supernova remnant.Signs of ExplosionsSupernova remnants are spectacular structures formed by the ejecta of stellar explosions as they expand outwards into the surrounding interstellar medium.One peculiarity of these remnants is that they often exhibit asymmetries in their appearance and motion. Is this because the ejecta are expanding into a nonuniform interstellar medium? Or was the explosion itself asymmetric? The best way we can explore this question is with detailed observations of the remnants.Histograms of the velocity in distribution of the knots in the X (green), Y (blue) and Z (red) directions (+Z is away from the observer). They show no evidence for asymmetric expansion of the knots. [Williams et al. 2017]Enter TychoTo this end, a team of scientists led by Brian Williams (Space Telescope Science Institute and NASA Goddard SFC) has worked to map out the 3D velocities of the ejecta in the Tycho supernova remnant. Tycho is a Type Ia supernova thought to be caused by the thermonuclear explosion of a white dwarf in a binary system that was destabilized by mass transfer from its companion.After 450 years of expansion, the remnant now has the morphological appearance of a roughly circular cloud of clumpy ejecta. The forward shock wave from the supernova, however, is known to have twice the velocity on one side of the shell as on the other.To better understand this asymmetry, Williams and collaborators selected a total of 57 knots in Tychos ejecta, spread out around the remnant. They then used 12 years of

  19. Dispersion - does it degrade a pulse envelope

    International Nuclear Information System (INIS)

    Deighton, M.O.

    1985-01-01

    In hostile environments, transmitting information as ultrasonic Lamb wave pulses has advantages, since the stainless steel strip serving as a waveguide is very durable. Besides attenuation, velocity dispersion (inherent in Lamb waves) can be important even in fairly short guides. Theory shows that unlimited propagation of a pulsed r.f. envelope is possible, even with dispersion present. The constant group velocity needed would favour asub(o)-mode pulses over other modes, provided ordinary attenuation is small. An approximate formula indicates the useful range of a pulse, when group velocity does vary. (author)

  20. Shape Control of Responsive Building Envelopes

    DEFF Research Database (Denmark)

    Foged, Isak Worre; Kirkegaard, Poul Henning; Christensen, Jesper Thøger

    2010-01-01

    The present paper considers shape control of adaptive architectural structures for improvement of structural performance by recognizing changes in their environments and loads, adapting to meet goals, and using past events to improve future performance or maintain serviceability. The general scop...... environmental system to a primary structural system joint into a collective behavioral system equipment with an actuator system is presented....... alternatives. The adaptive structure is a proposal for a responsive building envelope which is an idea of a first level operational framework for present and future investigations towards performance based responsive architectures through a set of responsive typologies. A mock-up concept of a secondary...

  1. Snell Envelope with Small Probability Criteria

    Energy Technology Data Exchange (ETDEWEB)

    Del Moral, Pierre, E-mail: Pierre.Del-Moral@inria.fr; Hu, Peng, E-mail: Peng.Hu@inria.fr [Universite de Bordeaux I, Centre INRIA Bordeaux et Sud-Ouest and Institut de Mathematiques de Bordeaux (France); Oudjane, Nadia, E-mail: Nadia.Oudjane@edf.fr [EDF R and D Clamart (France)

    2012-12-15

    We present a new algorithm to compute the Snell envelope in the specific case where the criteria to optimize is associated with a small probability or a rare event. This new approach combines the Stochastic Mesh approach of Broadie and Glasserman with a particle approximation scheme based on a specific change of measure designed to concentrate the computational effort in regions pointed out by the criteria. The theoretical analysis of this new algorithm provides non asymptotic convergence estimates. Finally, the numerical tests confirm the practical interest of this approach.

  2. Remnant trees affect species composition but not structure of tropical second-growth forest.

    Science.gov (United States)

    Sandor, Manette E; Chazdon, Robin L

    2014-01-01

    Remnant trees, spared from cutting when tropical forests are cleared for agriculture or grazing, act as nuclei of forest regeneration following field abandonment. Previous studies on remnant trees were primarily conducted in active pasture or old fields abandoned in the previous 2-3 years, and focused on structure and species richness of regenerating forest, but not species composition. Our study is among the first to investigate the effects of remnant trees on neighborhood forest structure, biodiversity, and species composition 20 years post-abandonment. We compared the woody vegetation around individual remnant trees to nearby plots without remnant trees in the same second-growth forests ("control plots"). Forest structure beneath remnant trees did not differ significantly from control plots. Species richness and species diversity were significantly higher around remnant trees. The species composition around remnant trees differed significantly from control plots and more closely resembled the species composition of nearby old-growth forest. The proportion of old-growth specialists and generalists around remnant trees was significantly greater than in control plots. Although previous studies show that remnant trees may initially accelerate secondary forest growth, we found no evidence that they locally affect stem density, basal area, and seedling density at later stages of regrowth. Remnant trees do, however, have a clear effect on the species diversity, composition, and ecological groups of the surrounding woody vegetation, even after 20 years of forest regeneration. To accelerate the return of diversity and old-growth forest species into regrowing forest on abandoned land, landowners should be encouraged to retain remnant trees in agricultural or pastoral fields.

  3. Envelope as Climate Negotiator: Evaluating adaptive building envelope's capacity to moderate indoor climate and energy

    Science.gov (United States)

    Erickson, James

    Through manipulation of adaptable opportunities available within a given environment, individuals become active participants in managing personal comfort requirements, by exercising control over their comfort without the assistance of mechanical heating and cooling systems. Similarly, continuous manipulation of a building skin's form, insulation, porosity, and transmissivity qualities exerts control over the energy exchanged between indoor and outdoor environments. This research uses four adaptive response variables in a modified software algorithm to explore an adaptive building skin's potential in reacting to environmental stimuli with the purpose of minimizing energy use without sacrificing occupant comfort. Results illustrate that significant energy savings can be realized with adaptive envelopes over static building envelopes even under extreme summer and winter climate conditions; that the magnitude of these savings are dependent on climate and orientation; and that occupant thermal comfort can be improved consistently over comfort levels achieved by optimized static building envelopes. The resulting adaptive envelope's unique climate-specific behavior could inform designers in creating an intelligent kinetic aesthetic that helps facilitate adaptability and resiliency in architecture.

  4. A modified theoretical Σ − D relation for supernova remnants: I. The case of constant temperature within the supernova remnant

    Directory of Open Access Journals (Sweden)

    Urošević Dejan V.

    2003-01-01

    Full Text Available We present a modification of the theoretical Σ − D relation for supernova remnants (SNRs in the adiabatic expansion phase. This modification is based on the convolution of the relation first derived by Shklovsky with the Σ − D relation derived in this paper for thermal bremsstrahlung radiation from the ionized gas cloud. We adopt McKee & Ostriker’s model for the components of the interstellar medium as part of our derivation. The modified Shklovsky theory agrees well with empirical results. Kesteven’s modified theoretical relation gives the best agreement with the updated Galactic empirical Σ − D relation.

  5. The performance of energy efficient residential building envelope systems

    Energy Technology Data Exchange (ETDEWEB)

    Proskiw, G.

    1996-08-01

    The adequacy and durability of residential building envelope systems under actual field conditions were evaluated. A building envelope offers protection from cold, heat, moisture, wind and noise. However, they are exposed to thermal, structural, and moisture stresses and their performance can degrade over time. Envelope performance was evaluated at 20 energy efficient and four conventional, detached modern homes in Winnipeg, Canada. The three complementary measurement tools were wood moisture content (WMC) of framing members, thermographic examinations, and airtightness tests. As expected, energy efficient building envelope systems performed better than the conventional systems. No evidence of envelope degradation was found in any of the energy efficient houses. The building envelopes using polyethylene air barriers performed slightly better than those which used the airtight drywall approach, although both were considered satisfactory. WMC levels were a bit lower in the polyethylene-clad house. 1 ref., 1 tab.

  6. Improved optical spectrophotometry of supernova remnants in M33

    Science.gov (United States)

    Blair, W. P.; Kirshner, R. P.

    1985-01-01

    Optical spectra of SNRs in M33 have been used to investigate abundance gradients and SNR evolution in this galaxy. Abundances of O, N, and S are derived from the spectra using new shock models by Dopita et al. (1984). The results for N and S show abundance gradients similar to those in NGC 300 and the Galaxy. The O abundances may be affected by possible contamination from H II regions and low-velocity shocks. Electron densities derived from the forbidden S II 6717 A/6731 A line ratio are used with a pressure equilibrium argument to estimate the initial explosion energy for each SNR. Evolutionary models for the remnants are investigated, and the distribution of the number of remnants with diameter is found to be consistent with free expansion of the SNRs to diameters of about 26 pc. The results may also be consistent with Sedov evolution if the ranges of initial supernova energies and surrounding interstellar medium densities are large enough.

  7. DESTRUCTION OF INTERSTELLAR DUST IN EVOLVING SUPERNOVA REMNANT SHOCK WAVES

    International Nuclear Information System (INIS)

    Slavin, Jonathan D.; Dwek, Eli; Jones, Anthony P.

    2015-01-01

    Supernova generated shock waves are responsible for most of the destruction of dust grains in the interstellar medium (ISM). Calculations of the dust destruction timescale have so far been carried out using plane parallel steady shocks, however, that approximation breaks down when the destruction timescale becomes longer than that for the evolution of the supernova remnant (SNR) shock. In this paper we present new calculations of grain destruction in evolving, radiative SNRs. To facilitate comparison with the previous study by Jones et al., we adopt the same dust properties as in that paper. We find that the efficiencies of grain destruction are most divergent from those for a steady shock when the thermal history of a shocked gas parcel in the SNR differs significantly from that behind a steady shock. This occurs in shocks with velocities ≳200 km s −1 for which the remnant is just beginning to go radiative. Assuming SNRs evolve in a warm phase dominated ISM, we find dust destruction timescales are increased by a factor of ∼2 compared to those of Jones et al., who assumed a hot gas dominated ISM. Recent estimates of supernova rates and ISM mass lead to another factor of ∼3 increase in the destruction timescales, resulting in a silicate grain destruction timescale of ∼2–3 Gyr. These increases, while not able to resolve the problem of the discrepant timescales for silicate grain destruction and creation, are an important step toward understanding the origin and evolution of dust in the ISM

  8. RADIO POLARIMETRY SIGNATURES OF STRONG MAGNETIC TURBULENCE IN SUPERNOVA REMNANTS

    International Nuclear Information System (INIS)

    Stroman, Wendy; Pohl, Martin

    2009-01-01

    We discuss the emission and transport of polarized radio-band synchrotron radiation near the forward shocks of young shell-type supernova remnants, for which X-ray data indicate a strong amplification of turbulent magnetic field. Modeling the magnetic turbulence through the superposition of waves, we calculate the degree of polarization and the magnetic polarization direction which is at 90 deg. to the conventional electric polarization direction. We find that isotropic strong turbulence will produce weakly polarized radio emission even in the absence of internal Faraday rotation. If anisotropy is imposed on the magnetic-field structure, the degree of polarization can be significantly increased, provided internal Faraday rotation is inefficient. Both for shock compression and a mixture with a homogeneous field, the increase in polarization degree goes along with a fairly precise alignment of the magnetic-polarization angle with the direction of the dominant magnetic-field component, implying tangential magnetic polarization at the rims in the case of shock compression. We compare our model with high-resolution radio polarimetry data of Tycho's remnant. Using the absence of internal Faraday rotation we find a soft limit for the amplitude of magnetic turbulence, δB ∼ 0 . An alternative viable scenario involves anisotropic turbulence with stronger amplitudes in the radial direction, as was observed in recent Magnetohydrodynamics simulations of shocks propagating through a medium with significant density fluctuations.

  9. [Management of urachal remnants in children: Is surgical excision mandatory?].

    Science.gov (United States)

    Heuga, B; Mouttalib, S; Bouali, O; Juricic, M; Galinier, P; Abbo, O

    2015-09-01

    The classical management of urachal remants consists in surgical resection, in order to prevent infections and long term malignancies. However, some reports have recently spread a wait and see management. The aim of our study was to report the results of the surgical management in our center. We conducted a retrospective, monocentric review of all patients managed for urachal remnants from January 2005 to December 2014. Thirty-five patients have been operated during the study period (18 girls and 17 boys). Mean age at surgery was 4,9±4,4 years old. Twenty-seven patients were referred due to symptoms whereas 8 were discovered incidentally (4 by ultrasound scan and 4 during laparoscopy). Among them, 10 were urachal cysts, 15 were urachus sinusa and 10 were patent urachus. Thirty were operated using an open approach and 5 using a laparoscopic approach. Mean length of stay was 3,8±1,7days (1-10) with a mean duration of bladder drainage of 2,5±1 days. No major complications occurred. No abnormal tissue was discovered at the histological analysis. Presentation of urachal remnants is variable but surgical outcomes remain excellent in our experience. When symptoms occur, the surgical decision is easy, but when the diagnosis is incidental, the decision is much more complicated. Official guidelines could ease the decision process and the management of urachal anomalies. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  10. FERMI LARGE AREA TELESCOPE OBSERVATION OF SUPERNOVA REMNANT S147

    Energy Technology Data Exchange (ETDEWEB)

    Katsuta, J.; Uchiyama, Y.; Tanaka, T.; Tajima, H.; Bechtol, K.; Funk, S.; Lande, J. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Ballet, J. [Laboratoire AIM, CEA-IRFU/CNRS/Universite Paris Diderot, Service d' Astrophysique, CEA Saclay, 91191 Gif sur Yvette (France); Hanabata, Y. [Department of Physical Sciences, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526 (Japan); Lemoine-Goumard, M. [Universite Bordeaux 1, CNRS/IN2p3, Centre d' Etudes Nucleaires de Bordeaux Gradignan, 33175 Gradignan (France); Takahashi, T., E-mail: katsuta@slac.stanford.edu, E-mail: uchiyama@slac.stanford.edu [Institute of Space and Astronautical Science, Japanese Aerospace Exploration Agency, 3-1-1 Yoshinodai, Chuo-ku, Sagamihara, Kanagawa 252-5210 (Japan)

    2012-06-20

    We present an analysis of gamma-ray data obtained with the Large Area Telescope on board the Fermi Gamma-ray Space Telescope in the region around supernova remnant (SNR) S147 (G180.0-1.7). A spatially extended gamma-ray source detected in an energy range of 0.2-10 GeV is found to coincide with SNR S147. We confirm its spatial extension at >5{sigma} confidence level. The gamma-ray flux is (3.8 {+-} 0.6) Multiplication-Sign 10{sup -8} photons cm{sup -2} s{sup -1}, corresponding to a luminosity of 1.3 Multiplication-Sign 10{sup 34} (d/1.3 kpc){sup 2} erg s{sup -1} in this energy range. The gamma-ray emission exhibits a possible spatial correlation with the prominent H{alpha} filaments of SNR S147. There is no indication that the gamma-ray emission comes from the associated pulsar PSR J0538+2817. The gamma-ray spectrum integrated over the remnant is likely dominated by the decay of neutral {pi} mesons produced through the proton-proton collisions in the filaments. The reacceleration of the pre-existing cosmic rays and subsequent adiabatic compression in the filaments is sufficient to provide the energy density required of high-energy protons.

  11. Population III Stars and Remnants in High-redshift Galaxies

    Science.gov (United States)

    Xu, Hao; Wise, John H.; Norman, Michael L.

    2013-08-01

    Recent simulations of Population III star formation have suggested that some fraction form in binary systems, in addition to having a characteristic mass of tens of solar masses. The deaths of metal-free stars result in the initial chemical enrichment of the universe and the production of the first stellar-mass black holes. Here we present a cosmological adaptive mesh refinement simulation of an overdense region that forms a few 109 M ⊙ dark matter halos and over 13,000 Population III stars by redshift 15. We find that most halos do not form Population III stars until they reach M vir ~ 107 M ⊙ because this biased region is quickly enriched from both Population III and galaxies, which also produce high levels of ultraviolet radiation that suppress H2 formation. Nevertheless, Population III stars continue to form, albeit in more massive halos, at a rate of ~10-4 M ⊙ yr-1 Mpc-3 at redshift 15. The most massive starless halo has a mass of 7 × 107 M ⊙, which could host massive black hole formation through the direct gaseous collapse scenario. We show that the multiplicity of the Population III remnants grows with halo mass above 108 M ⊙, culminating in 50 remnants located in 109 M ⊙ halos on average. This has implications that high-mass X-ray binaries and intermediate-mass black holes that originate from metal-free stars may be abundant in high-redshift galaxies.

  12. Dust in Supernovae and Supernova Remnants II: Processing and Survival

    Science.gov (United States)

    Micelotta, E. R.; Matsuura, M.; Sarangi, A.

    2018-03-01

    Observations have recently shown that supernovae are efficient dust factories, as predicted for a long time by theoretical models. The rapid evolution of their stellar progenitors combined with their efficiency in precipitating refractory elements from the gas phase into dust grains make supernovae the major potential suppliers of dust in the early Universe, where more conventional sources like Asymptotic Giant Branch (AGB) stars did not have time to evolve. However, dust yields inferred from observations of young supernovae or derived from models do not reflect the net amount of supernova-condensed dust able to be expelled from the remnants and reach the interstellar medium. The cavity where the dust is formed and initially resides is crossed by the high velocity reverse shock which is generated by the pressure of the circumstellar material shocked by the expanding supernova blast wave. Depending on grain composition and initial size, processing by the reverse shock may lead to substantial dust erosion and even complete destruction. The goal of this review is to present the state of the art about processing and survival of dust inside supernova remnants, in terms of theoretical modelling and comparison to observations.

  13. Grain formation in cool stellar envelopes

    International Nuclear Information System (INIS)

    Deguchi, S.

    1980-01-01

    The nucleation and growth of dust grains in the stellar envelope are investigated for the case of oxygen-rich stars, where the mass loss occurs as a result of the radiation pressure on the dust grains. The number density of grains, the final grain sizes, and the final amount of metals remaining in gaseous states are calculated based on the grain-nucleation theory proposed by Yamamoto and Hasegawa and Draine and Salpeter. It is shown that, even if we base our calculations on the Lothe-Pound nucleation rate equation instead of the classical, homogeneous nucleation rate equation, the proposed theory gives a number density of grains quite similar to that based on the classical rate equation. The approximate solution of the flow, in this paper, brings physical insight to the problem of how the formation of grains couples the flow passing the sonic point. The metals in the outer envelope remain in gaseous state by the amount of 1--10% of the initial content for the mass-loss rate of 10 -5 M/sub sun/ yr -1 and by less than 1% for the massloss are less than 3 x 10 -6 M/sub sun/ yr -1 . Species of metals condensed onto the grains are also discussed

  14. Bellanca building, Yellowknife : building envelope retrofit project

    Energy Technology Data Exchange (ETDEWEB)

    Rajewski, G. [A.D. Williams Engineering Inc., Edmonton, AB (Canada)

    2008-07-01

    The Bellanca building is a ten-story, commercial office building, located in Yellowknife, Northwest Territories. The owner was concerned about annual fuel consumption, relative to other buildings of similar size. Tenants reported cold drafts and some ice build-up had been reported in the past, on the exterior of the cladding. In addition, some water penetration had occurred during rainfall. This presentation provided background information on the Bellanca building and discussed a building envelope retrofit project. A.D. Williams was hired in late 2006 in order to provide an opinion on the present condition of the building envelope. This presentation described the site investigation and presented an interior and exterior review of the building. It also presented a thermographic survey in order to map thermal anomalies and establish trends. Following acceptance of the report on findings, one of five options was selected for further development. This included removal of existing cladding, exterior gypsum wallboard, fiberglass insulation and application of BASF Walltite CT foam, sheathing, rigid insulation, drainage plane and new cladding. The preliminary design was then presented. This paper also described the tender and award of the contract; construction phase; and substantial completion of the project. tabs, figs.

  15. Chemistry of Protostellar Envelopes and Disks

    Science.gov (United States)

    Flores Rivera, Lizxandra; Terebey, Susan; Willacy, Karen

    2018-06-01

    Molecule formation is dynamic during the protostar collapse phase, driven by changes in temperature, density, and UV radiation as gas and dust flows from the envelope onto the forming protoplanetary disk. In this work, we compare physical models based on two different collapse solutions. We modeled the chemistry (created by Karen Willacy) for C18O to see how its abundance changes over time using as primary input parameters the temperature and density profile that were produced by the dust Radiative Transfer (MCRT) model called HOCHUNK3D from Whitney (2003). Given this model, we produce synthetic line emission maps from L1527 IRS to simulate the Class 0/I protostar L1527 IRS using RADMC3D code and compare them with previous observations from ALMA. High concentrations of gas phase molecules of C18O are found within the 20 AU in areas in the envelope that are close to the surface of the disk. In the outermost part of the disk surface, the C18O freezes out beyond 400 AU, showing a much reduced abundance where the temperature profile drops down below 25 K. In cold regions, the radiation field plays an important role in the chemistry.

  16. [An improved algorithm for electrohysterogram envelope extraction].

    Science.gov (United States)

    Lu, Yaosheng; Pan, Jie; Chen, Zhaoxia; Chen, Zhaoxia

    2017-02-01

    Extraction uterine contraction signal from abdominal uterine electromyogram(EMG) signal is considered as the most promising method to replace the traditional tocodynamometer(TOCO) for detecting uterine contractions activity. The traditional root mean square(RMS) algorithm has only some limited values in canceling the impulsive noise. In our study, an improved algorithm for uterine EMG envelope extraction was proposed to overcome the problem. Firstly, in our experiment, zero-crossing detection method was used to separate the burst of uterine electrical activity from the raw uterine EMG signal. After processing the separated signals by employing two filtering windows which have different width, we used the traditional RMS algorithm to extract uterus EMG envelope. To assess the performance of the algorithm, the improved algorithm was compared with two existing intensity of uterine electromyogram(IEMG) extraction algorithms. The results showed that the improved algorithm was better than the traditional ones in eliminating impulsive noise present in the uterine EMG signal. The measurement sensitivity and positive predictive value(PPV) of the improved algorithm were 0.952 and 0.922, respectively, which were not only significantly higher than the corresponding values(0.859 and 0.847) of the first comparison algorithm, but also higher than the values(0.928 and 0.877) of the second comparison algorithm. Thus the new method is reliable and effective.

  17. Solution of K-V envelope equations

    International Nuclear Information System (INIS)

    Anderson, O.A.

    1995-04-01

    The envelope equations for a KV beam with space charge have been analyzed systematically by an e expansion followed by integrations. The focusing profile as a function of axial length is assumed to be symmetric but otherwise arbitrary. Given the bean current, emittance, and peak focusing field, we find the envelopes a(s) and b(s) and obtain , a max , σ, and σ 0 . Explicit results are presented for various truncations of the expansion. The zeroth order results correspond to those from the well-known smooth approximation; the same convenient format is retained for the higher order cases. The first order results, involving single correction terms, give 3--10 times better accuracy and are good to ∼1% at σ 0 = 70 degree. Third order gives a factor of 10--30 improvement over the smooth approximation and derived quantities accurate to ∼1% at σ 0 = 112 degree. The first order expressions are convenient design tools. They lend themselves to variable energy problems and have been applied to the design, construction, and testing of ESQ accelerators at LBL

  18. Solitons, envelope solitons in collisonless plasmas

    International Nuclear Information System (INIS)

    Ichikawa, Y.H.; Watanabe, S.

    1977-08-01

    A review is given to extensive development of theoretical, computational and experimental studies of nonlinear wave propagation in collisionless plasmas. Firstly, the historical experiment of Ikezi et al. is discussed in comparison with theoretical analysis based on the Korteweg-de Vries equation. Systematic discrepancy between the observation and the theoretical prediction suggests that it is necessary to examine such as higher order mode coupling effect and contribution of trapped particles. Secondly, effects of the nonlinear Landau damping on the envelope solution of ion plasma wave is discussed on the basis of theoretical study of Ichikawa-Taniuti, experimental observation of Watanabe and numerical analysis of Yajima et al. Finally, a new type of evolution equation derived for the Alfven wave is examined in some detail. The rigorous solution obtained for this mode represents a new kind of envelope solution, in which both of its phase and amplitude are subject to modulation of comparable spatial extension. In conclusion, the emphasis will be placed on the fact that much more intensive experimental researches are expected to be done, since the powerful methods to disentangle various nonlinear evolution equations are now available for theoretical approach. (auth.)

  19. A blowout numerical model for the supernova remnant G352.7-0.1

    OpenAIRE

    Toledo Roy, J. C.; Velazquez, P. F.; Esquivel, A.; Giacani, Elsa Beatriz

    2017-01-01

    We present 3D hydrodynamical simulations of the Galactic supernova remnant G352.7−0.1. This remnant is peculiar for having a shell-like inner ring structure and an outer arc in radio observations. In our model, the supernova explosion producing the remnant occurs inside and near the border of a spherical cloud with a density higher than that of the surrounding interstellar medium. A blowout is produced when the remnant reaches the border of the cloud. We have then used the results of our hydr...

  20. Pancreatic Cancer Arising From the Remnant Pancreas: Is It a Local Recurrence or New Primary Lesion?

    Science.gov (United States)

    Hashimoto, Daisuke; Chikamoto, Akira; Masuda, Toshiro; Nakagawa, Shigeki; Imai, Katsunori; Yamashita, Yo-Ichi; Reber, Howard A; Baba, Hideo

    2017-10-01

    Local recurrence of pancreatic cancer (PC) can occur in the pancreatic remnant. In addition, new primary PC can develop in the remnant. There are limited data available regarding this so-called remnant PC. The aim of this review was to describe the characteristics and therapeutic strategy regarding remnant PC. A literature search was performed using Medline published in English according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The incidence of remnant PC has been reported to be 3% to 5%. It is difficult to distinguish local recurrence from new primary PC. Genetic diagnosis such as Kirsten rat sarcoma viral oncogene homolog mutation may resolve this problem. For patients with remnant PC, repeated pancreatectomy can be performed. Residual total pancreatectomy is the most common procedure. Recent studies have described the safety of the operation because of recent surgical progress and perioperative care. The patients with remnant PC without distant metastasis have shown good long-term outcomes, especially those who underwent repeated pancreatectomy. Adjuvant chemotherapy may contribute to longer survival. In conclusion, this review found that both local recurrence and new primary PC can develop in the pancreatic remnant. Repeated pancreatectomy for the remnant PC is a feasible procedure and can prolong patient survival.

  1. Adaptive Flight Envelope Estimation and Protection, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Impact Technologies, in collaboration with the Georgia Institute of Technology, proposes to develop and demonstrate an innovative flight envelope estimation and...

  2. Nuclear theory group progress report and renewal proposal, December 1, 1981-November 30, 1984

    International Nuclear Information System (INIS)

    Brown, G.E.; Jackson, A.D.; Kuo, T.T.S.

    1981-01-01

    The work of the Stony Brook Nuclear Theory Group covers a broad range of topics in theoretical nuclear structure. Primary emphasis is placed on understanding the origin of the nucleon-nucleon and meson-nucleon interactions. Phenomenological treatments of QCD, using chiral invariance as a guide, are central to our efforts here; through the chiral bag model they give us also an improved understanding of the structure of hadrons. Starting from the free interaction, many-body techniques have been used to construct the effective interaction between nucleons in nuclei. Analysis of a wide range of nuclear phenomena has been carried out using such effective interactions. Among the most interesting are nuclear giant resonances for which we offer a dynamical theory of nuclear vibrations which emphasizes the energy dependence of the effective interaction. Continuing our earlier description of the collapse of large stars, we have worked out the formation of the shock wave upon bounce, and its progress out through the star. We believe this shock wave to blow off the mantle and envelope of the star, leaving a compact remnant, the pulsar. Computer calculations follow this scenario until the shock is some distance beyond the neutrino sphere, where the shock then runs out of energy. We are extending these calculations to a description of explosive nucleosynthesis. We have also been studying heavy ion reactions. In the low-energy regime, we have concentrated on nuclear quasimolecular states, and on the angular dependence of deep inelastic scattering. In the relativistic regime, we wish to extend our old work on states of dense matter

  3. THE COOLING OF THE CASSIOPEIA A NEUTRON STAR AS A PROBE OF THE NUCLEAR SYMMETRY ENERGY AND NUCLEAR PASTA

    Energy Technology Data Exchange (ETDEWEB)

    Newton, William G.; Hooker, Joshua; Li, Bao-An [Department of Physics and Astronomy, Texas A and M University-Commerce, Commerce, TX 75429-3011 (United States); Murphy, Kyleah [Umpqua Community College, Roseburg, OR 97470 (United States)

    2013-12-10

    X-ray observations of the neutron star (NS) in the Cas A supernova remnant over the past decade suggest the star is undergoing a rapid drop in surface temperature of ≈2%-5.5%. One explanation suggests the rapid cooling is triggered by the onset of neutron superfluidity in the core of the star, causing enhanced neutrino emission from neutron Cooper pair breaking and formation (PBF). Using consistent NS crust and core equations of state (EOSs) and compositions, we explore the sensitivity of this interpretation to the density dependence of the symmetry energy L of the EOS used, and to the presence of enhanced neutrino cooling in the bubble phases of crustal ''nuclear pasta''. Modeling cooling over a conservative range of NS masses and envelope compositions, we find L ≲ 70 MeV, competitive with terrestrial experimental constraints and other astrophysical observations. For masses near the most likely mass of M ≳ 1.65 M {sub ☉}, the constraint becomes more restrictive 35 ≲ L ≲ 55 MeV. The inclusion of the bubble cooling processes decreases the cooling rate of the star during the PBF phase, matching the observed rate only when L ≲ 45 MeV, taking all masses into consideration, corresponding to NS radii ≲ 11 km.

  4. Outflow-Induced Dynamical and Radiative Instability in Stellar Envelopes with an Application to Luminous Blue Variables and Wolf-Rayet Stars

    Science.gov (United States)

    Stothers, Richard B.; Hansen, James E. (Technical Monitor)

    2002-01-01

    Theoretical models of the remnants of massive stars in a very hot, post-red-supergiant phase display no obvious instability if standard assumptions are made. However, the brightest observed classical luminous blue variables (LBVs) may well belong to such a phase. A simple time-dependent theory of moving stellar envelopes is developed in order to treat deep hydrodynamical disturbances caused by surface mass loss and to test the moving envelopes for dynamical instability. In the case of steady-state outflow, the theory reduces to the equivalent of the Castor, Abbott, and Klein formulation for optically thick winds at distances well above the sonic point. The time-dependent version indicates that the brightest and hottest LBVs are both dynamically and radiatively unstable, as a result of the substantial lowering of the generalized Eddington luminosity limit by the mass-loss acceleration. It is suggested that dynamical instability, by triggering secular cycles of mass loss, is primarily what differentiates LBVs from the purely radiatively unstable Wolf-Rayet stars. Furthermore, when accurate main-sequence mass-loss rates are used to calculate the evolutionary tracks, the predicted surface hydrogen and nitrogen abundances of the blue remnants agree much better with observations of the brightest LBVs than before.

  5. NUMERICAL STUDY OF THE VISHNIAC INSTABILITY IN SUPERNOVA REMNANTS

    International Nuclear Information System (INIS)

    Michaut, C.; Cavet, C.; Bouquet, S. E.; Roy, F.; Nguyen, H. C.

    2012-01-01

    The Vishniac instability is thought to explain the complex structure of radiative supernova remnants in their Pressure-Driven Thin Shell (PDTS) phase after a blast wave (BW) has propagated from a central explosion. In this paper, the propagation of the BW and the evolution of the PDTS stage are studied numerically with the two-dimensional (2D) code HYDRO-MUSCL for a finite-thickness shell expanding in the interstellar medium (ISM). Special attention is paid to the adiabatic index, γ, and three distinct values are taken for the cavity (γ 1 ), the shell (γ 2 ), and the ISM (γ 3 ) with the condition γ 2 1 , γ 3 . This low value of γ 2 accounts for the high density in the shell achieved by a strong radiative cooling. Once the spherical background flow is obtained, the evolution of a 2D-axisymmetric perturbation is computed from the linear to the nonlinear regime. The overstable mechanism, previously demonstrated theoretically by E. T. Vishniac in 1983, is recovered numerically in the linear stage and is expected to produce and enhance anisotropies and clumps on the shock front, leading to the disruption of the shell in the nonlinear phase. The period of the increasing oscillations and the growth rate of the instability are derived from several points of view (the position of the perturbed shock front, mass fluxes along the shell, and density maps), and the most unstable mode differing from the value given by Vishniac is computed. In addition, the influence of several parameters (the Mach number, amplitude and wavelength of the perturbation, and adiabatic index) is examined and for wavelengths that are large enough compared to the shell thickness, the same conclusion arises: in the late stage of the evolution of the radiative supernova remnant, the instability is dampened and the angular initial deformation of the shock front is smoothed while the mass density becomes uniform with the angle. As a result, our model shows that the supernova remnant returns to a

  6. Radiative transfer in spherical circumstellar dust envelopes. III. Dust envelope models of some well known infrared stars

    International Nuclear Information System (INIS)

    Apruzese, J.P.

    1975-01-01

    The radiative transfer techniques described elsewhere by the author have been employed to construct dust envelope models of several well known infrared stars. The resulting calculations indicate that the infrared emissivity of circumstellar grains generally must be higher than that which many calculations of small nonsilicate grains yield. This conclusion is dependent to some degree on the (unknown) size of the stellar envelopes considered, but is quite firm in the case of the spatially resolved envelope of IRC+10216. Further observations of the spatial distribution of the infrared radiation from stellar envelopes will be invaluable in deciphering the properties of the circumstellar grains

  7. Polarimetry and physics of Be star envelopes

    International Nuclear Information System (INIS)

    Coyne, G.V.; McLean, I.S.

    1982-01-01

    A review of the most recent developments in polarization studies of Be stars is presented. New polarization techniques for high-resolution spectropolarimetry and for near infrared polarimetry are described and a wide range of new observations are discussed. These include broad-band, intermediate-band and multichannel observations of the continuum polarization of Be stars in the wavelength interval 0.3-2.2 microns, high resolution (0.5 A) line profile polarimetry of a few stars and surveys of many stars for the purposes of statistical analyses. The physical significance of the observational material is discussed in the light of recent theoretical models. Emphasis is placed on the physical and geometrical parameters of Be star envelopes which polarimetry helps to determine. (Auth.)

  8. Enveloping branes and brane-world singularities

    Energy Technology Data Exchange (ETDEWEB)

    Antoniadis, Ignatios; Cotsakis, Spiros [CERN-Theory Division, Department of Physics, Geneva 23 (Switzerland); Klaoudatou, Ifigeneia [University of the Aegean, Research Group of Geometry, Dynamical Systems and Cosmology, Department of Information and Communication Systems Engineering, Samos (Greece)

    2014-12-01

    The existence of envelopes is studied for systems of differential equations in connection with the method of asymptotic splittings which allows one to determine the singularity structure of the solutions. The result is applied to brane-worlds consisting of a 3-brane in a five-dimensional bulk, in the presence of an analog of a bulk perfect fluid parameterizing a generic class of bulk matter. We find that all flat brane solutions suffer from a finite-distance singularity contrary to previous claims. We then study the possibility of avoiding finite-distance singularities by cutting the bulk and gluing regular solutions at the position of the brane. Further imposing physical conditions such as finite Planck mass on the brane and positive energy conditions on the bulk fluid, excludes, however, this possibility as well. (orig.)

  9. Performance measurement with fuzzy data envelopment analysis

    CERN Document Server

    Tavana, Madjid

    2014-01-01

    The intensity of global competition and ever-increasing economic uncertainties has led organizations to search for more efficient and effective ways to manage their business operations.  Data envelopment analysis (DEA) has been widely used as a conceptually simple yet powerful tool for evaluating organizational productivity and performance. Fuzzy DEA (FDEA) is a promising extension of the conventional DEA proposed for dealing with imprecise and ambiguous data in performance measurement problems. This book is the first volume in the literature to present the state-of-the-art developments and applications of FDEA. It is designed for students, educators, researchers, consultants and practicing managers in business, industry, and government with a basic understanding of the DEA and fuzzy logic concepts.

  10. Pushing the Envelope of Extreme Space Weather

    Science.gov (United States)

    Pesnell, W. D.

    2014-12-01

    Extreme Space Weather events are large solar flares or geomagnetic storms, which can cost billions of dollars to recover from. We have few examples of such events; the Carrington Event (the solar superstorm) is one of the few that had superlatives in three categories: size of solar flare, drop in Dst, and amplitude of aa. Kepler observations show that stars similar to the Sun can have flares releasing millions of times more energy than an X-class flare. These flares and the accompanying coronal mass ejections could strongly affect the atmosphere surrounding a planet. What level of solar activity would be necessary to strongly affect the atmosphere of the Earth? Can we map out the envelope of space weather along the evolution of the Sun? What would space weather look like if the Sun stopped producing a magnetic field? To what extreme should Space Weather go? These are the extremes of Space Weather explored in this talk.

  11. Data envelopment analysis of randomized ranks

    Directory of Open Access Journals (Sweden)

    Sant'Anna Annibal P.

    2002-01-01

    Full Text Available Probabilities and odds, derived from vectors of ranks, are here compared as measures of efficiency of decision-making units (DMUs. These measures are computed with the goal of providing preliminary information before starting a Data Envelopment Analysis (DEA or the application of any other evaluation or composition of preferences methodology. Preferences, quality and productivity evaluations are usually measured with errors or subject to influence of other random disturbances. Reducing evaluations to ranks and treating the ranks as estimates of location parameters of random variables, we are able to compute the probability of each DMU being classified as the best according to the consumption of each input and the production of each output. Employing the probabilities of being the best as efficiency measures, we stretch distances between the most efficient units. We combine these partial probabilities in a global efficiency score determined in terms of proximity to the efficiency frontier.

  12. Enhanced conformational sampling using enveloping distribution sampling.

    Science.gov (United States)

    Lin, Zhixiong; van Gunsteren, Wilfred F

    2013-10-14

    To lessen the problem of insufficient conformational sampling in biomolecular simulations is still a major challenge in computational biochemistry. In this article, an application of the method of enveloping distribution sampling (EDS) is proposed that addresses this challenge and its sampling efficiency is demonstrated in simulations of a hexa-β-peptide whose conformational equilibrium encompasses two different helical folds, i.e., a right-handed 2.7(10∕12)-helix and a left-handed 3(14)-helix, separated by a high energy barrier. Standard MD simulations of this peptide using the GROMOS 53A6 force field did not reach convergence of the free enthalpy difference between the two helices even after 500 ns of simulation time. The use of soft-core non-bonded interactions in the centre of the peptide did enhance the number of transitions between the helices, but at the same time led to neglect of relevant helical configurations. In the simulations of a two-state EDS reference Hamiltonian that envelops both the physical peptide and the soft-core peptide, sampling of the conformational space of the physical peptide ensures that physically relevant conformations can be visited, and sampling of the conformational space of the soft-core peptide helps to enhance the transitions between the two helices. The EDS simulations sampled many more transitions between the two helices and showed much faster convergence of the relative free enthalpy of the two helices compared with the standard MD simulations with only a slightly larger computational effort to determine optimized EDS parameters. Combined with various methods to smoothen the potential energy surface, the proposed EDS application will be a powerful technique to enhance the sampling efficiency in biomolecular simulations.

  13. Search for Post-merger Gravitational Waves from the Remnant of the Binary Neutron Star Merger GW170817

    Science.gov (United States)

    Abbott, B. P.; Abbott, R.; Abbott, T. D.; Acernese, F.; Ackley, K.; Adams, C.; Adams, T.; Addesso, P.; Adhikari, R. X.; Adya, V. B.; Affeldt, C.; Afrough, M.; Agarwal, B.; Agathos, M.; Agatsuma, K.; Aggarwal, N.; Aguiar, O. D.; Aiello, L.; Ain, A.; Ajith, P.; Allen, B.; Allen, G.; Allocca, A.; Altin, P. A.; Amato, A.; Ananyeva, A.; Anderson, S. B.; Anderson, W. G.; Angelova, S. V.; Antier, S.; Appert, S.; Arai, K.; Araya, M. C.; Areeda, J. S.; Arnaud, N.; Arun, K. G.; Ascenzi, S.; Ashton, G.; Ast, M.; Aston, S. M.; Astone, P.; Atallah, D. V.; Aufmuth, P.; Aulbert, C.; AultONeal, K.; Austin, C.; Avila-Alvarez, A.; Babak, S.; Bacon, P.; Bader, M. K. M.; Bae, S.; Baker, P. T.; Baldaccini, F.; Ballardin, G.; Ballmer, S. W.; Banagiri, S.; Barayoga, J. C.; Barclay, S. E.; Barish, B. C.; Barker, D.; Barkett, K.; Barone, F.; Barr, B.; Barsotti, L.; Barsuglia, M.; Barta, D.; Bartlett, J.; Bartos, I.; Bassiri, R.; Basti, A.; Batch, J. C.; Bawaj, M.; Bayley, J. C.; Bazzan, M.; Bécsy, B.; Beer, C.; Bejger, M.; Belahcene, I.; Bell, A. S.; Berger, B. K.; Bergmann, G.; Bernuzzi, S.; Bero, J. J.; Berry, C. P. L.; Bersanetti, D.; Bertolini, A.; Betzwieser, J.; Bhagwat, S.; Bhandare, R.; Bilenko, I. A.; Billingsley, G.; Billman, C. R.; Birch, J.; Birney, R.; Birnholtz, O.; Biscans, S.; Biscoveanu, S.; Bisht, A.; Bitossi, M.; Biwer, C.; Bizouard, M. A.; Blackburn, J. K.; Blackman, J.; Blair, C. D.; Blair, D. G.; Blair, R. M.; Bloemen, S.; Bock, O.; Bode, N.; Boer, M.; Bogaert, G.; Bohe, A.; Bondu, F.; Bonilla, E.; Bonnand, R.; Boom, B. A.; Bork, R.; Boschi, V.; Bose, S.; Bossie, K.; Bouffanais, Y.; Bozzi, A.; Bradaschia, C.; Brady, P. R.; Branchesi, M.; Brau, J. E.; Briant, T.; Brillet, A.; Brinkmann, M.; Brisson, V.; Brockill, P.; Broida, J. E.; Brooks, A. F.; Brown, D. A.; Brown, D. D.; Brunett, S.; Buchanan, C. C.; Buikema, A.; Bulik, T.; Bulten, H. J.; Buonanno, A.; Buskulic, D.; Buy, C.; Byer, R. L.; Cabero, M.; Cadonati, L.; Cagnoli, G.; Cahillane, C.; Calderón Bustillo, J.; Callister, T. A.; Calloni, E.; Camp, J. B.; Canepa, M.; Canizares, P.; Cannon, K. C.; Cao, H.; Cao, J.; Capano, C. D.; Capocasa, E.; Carbognani, F.; Caride, S.; Carney, M. F.; Casanueva Diaz, J.; Casentini, C.; Caudill, S.; Cavaglià, M.; Cavalier, F.; Cavalieri, R.; Cella, G.; Cepeda, C. B.; Cerdá-Durán, P.; Cerretani, G.; Cesarini, E.; Chamberlin, S. J.; Chan, M.; Chao, S.; Charlton, P.; Chase, E.; Chassande-Mottin, E.; Chatterjee, D.; Cheeseboro, B. D.; Chen, H. Y.; Chen, X.; Chen, Y.; Cheng, H.-P.; Chia, H.; Chincarini, A.; Chiummo, A.; Chmiel, T.; Cho, H. S.; Cho, M.; Chow, J. H.; Christensen, N.; Chu, Q.; Chua, A. J. K.; Chua, S.; Chung, A. K. W.; Chung, S.; Ciani, G.; Ciolfi, R.; Cirelli, C. E.; Cirone, A.; Clara, F.; Clark, J. A.; Clearwater, P.; Cleva, F.; Cocchieri, C.; Coccia, E.; Cohadon, P.-F.; Cohen, D.; Colla, A.; Collette, C. G.; Cominsky, L. R.; Constancio, M., Jr.; Conti, L.; Cooper, S. J.; Corban, P.; Corbitt, T. R.; Cordero-Carrión, I.; Corley, K. R.; Corsi, A.; Cortese, S.; Costa, C. A.; Coughlin, M. W.; Coughlin, S. B.; Coulon, J.-P.; Countryman, S. T.; Couvares, P.; Covas, P. B.; Cowan, E. E.; Coward, D. M.; Cowart, M. J.; Coyne, D. C.; Coyne, R.; Creighton, J. D. E.; Creighton, T. D.; Cripe, J.; Crowder, S. G.; Cullen, T. J.; Cumming, A.; Cunningham, L.; Cuoco, E.; Dal Canton, T.; Dálya, G.; Danilishin, S. L.; D'Antonio, S.; Danzmann, K.; Dasgupta, A.; Da Silva Costa, C. F.; Dattilo, V.; Dave, I.; Davier, M.; Davis, D.; Daw, E. J.; Day, B.; De, S.; DeBra, D.; Degallaix, J.; De Laurentis, M.; Deléglise, S.; Del Pozzo, W.; Demos, N.; Denker, T.; Dent, T.; De Pietri, R.; Dergachev, V.; De Rosa, R.; DeRosa, R. T.; De Rossi, C.; DeSalvo, R.; de Varona, O.; Devenson, J.; Dhurandhar, S.; Díaz, M. C.; Dietrich, T.; Di Fiore, L.; Di Giovanni, M.; Di Girolamo, T.; Di Lieto, A.; Di Pace, S.; Di Palma, I.; Di Renzo, F.; Doctor, Z.; Dolique, V.; Donovan, F.; Dooley, K. L.; Doravari, S.; Dorrington, I.; Douglas, R.; Dovale Álvarez, M.; Downes, T. P.; Drago, M.; Dreissigacker, C.; Driggers, J. C.; Du, Z.; Ducrot, M.; Dupej, P.; Dwyer, S. E.; Edo, T. B.; Edwards, M. C.; Effler, A.; Eggenstein, H.-B.; Ehrens, P.; Eichholz, J.; Eikenberry, S. S.; Eisenstein, R. A.; Essick, R. C.; Estevez, D.; Etienne, Z. B.; Etzel, T.; Evans, M.; Evans, T. M.; Factourovich, M.; Fafone, V.; Fair, H.; Fairhurst, S.; Fan, X.; Farinon, S.; Farr, B.; Farr, W. M.; Fauchon-Jones, E. J.; Favata, M.; Fays, M.; Fee, C.; Fehrmann, H.; Feicht, J.; Fejer, M. M.; Fernandez-Galiana, A.; Ferrante, I.; Ferreira, E. C.; Ferrini, F.; Fidecaro, F.; Finstad, D.; Fiori, I.; Fiorucci, D.; Fishbach, M.; Fisher, R. P.; Fitz-Axen, M.; Flaminio, R.; Fletcher, M.; Flynn, E.; Fong, H.; Font, J. A.; Forsyth, P. W. F.; Forsyth, S. S.; Fournier, J.-D.; Frasca, S.; Frasconi, F.; Frei, Z.; Freise, A.; Frey, R.; Frey, V.; Fries, E. M.; Fritschel, P.; Frolov, V. V.; Fulda, P.; Fyffe, M.; Gabbard, H.; Gadre, B. U.; Gaebel, S. M.; Gair, J. R.; Gammaitoni, L.; Ganija, M. R.; Gaonkar, S. G.; Garcia-Quiros, C.; Garufi, F.; Gateley, B.; Gaudio, S.; Gaur, G.; Gayathri, V.; Gehrels, N.; Gemme, G.; Genin, E.; Gennai, A.; George, D.; George, J.; Gergely, L.; Germain, V.; Ghonge, S.; Ghosh, Abhirup; Ghosh, Archisman; Ghosh, S.; Giaime, J. A.; Giardina, K. D.; Giazotto, A.; Gill, K.; Glover, L.; Goetz, E.; Goetz, R.; Gomes, S.; Goncharov, B.; González, G.; Gonzalez Castro, J. M.; Gopakumar, A.; Gorodetsky, M. L.; Gossan, S. E.; Gosselin, M.; Gouaty, R.; Grado, A.; Graef, C.; Granata, M.; Grant, A.; Gras, S.; Gray, C.; Greco, G.; Green, A. C.; Gretarsson, E. M.; Groot, P.; Grote, H.; Grunewald, S.; Gruning, P.; Guidi, G. M.; Guo, X.; Gupta, A.; Gupta, M. K.; Gushwa, K. E.; Gustafson, E. K.; Gustafson, R.; Halim, O.; Hall, B. R.; Hall, E. D.; Hamilton, E. Z.; Hammond, G.; Haney, M.; Hanke, M. M.; Hanks, J.; Hanna, C.; Hannam, M. D.; Hannuksela, O. A.; Hanson, J.; Hardwick, T.; Harms, J.; Harry, G. M.; Harry, I. W.; Hart, M. J.; Haster, C.-J.; Haughian, K.; Healy, J.; Heidmann, A.; Heintze, M. C.; Heitmann, H.; Hello, P.; Hemming, G.; Hendry, M.; Heng, I. S.; Hennig, J.; Heptonstall, A. W.; Heurs, M.; Hild, S.; Hinderer, T.; Hoak, D.; Hofman, D.; Holt, K.; Holz, D. E.; Hopkins, P.; Horst, C.; Hough, J.; Houston, E. A.; Howell, E. J.; Hreibi, A.; Hu, Y. M.; Huerta, E. A.; Huet, D.; Hughey, B.; Husa, S.; Huttner, S. H.; Huynh-Dinh, T.; Indik, N.; Inta, R.; Intini, G.; Isa, H. N.; Isac, J.-M.; Isi, M.; Iyer, B. R.; Izumi, K.; Jacqmin, T.; Jani, K.; Jaranowski, P.; Jawahar, S.; Jiménez-Forteza, F.; Johnson, W. W.; Jones, D. I.; Jones, R.; Jonker, R. J. G.; Ju, L.; Junker, J.; Kalaghatgi, C. V.; Kalogera, V.; Kamai, B.; Kandhasamy, S.; Kang, G.; Kanner, J. B.; Kapadia, S. J.; Karki, S.; Karvinen, K. S.; Kasprzack, M.; Kastaun, W.; Katolik, M.; Katsavounidis, E.; Katzman, W.; Kaufer, S.; Kawabe, K.; Kéfélian, F.; Keitel, D.; Kemball, A. J.; Kennedy, R.; Kent, C.; Key, J. S.; Khalili, F. Y.; Khan, I.; Khan, S.; Khan, Z.; Khazanov, E. A.; Kijbunchoo, N.; Kim, Chunglee; Kim, J. C.; Kim, K.; Kim, W.; Kim, W. S.; Kim, Y.-M.; Kimbrell, S. J.; King, E. J.; King, P. J.; Kinley-Hanlon, M.; Kirchhoff, R.; Kissel, J. S.; Kleybolte, L.; Klimenko, S.; Knowles, T. D.; Koch, P.; Koehlenbeck, S. M.; Koley, S.; Kondrashov, V.; Kontos, A.; Korobko, M.; Korth, W. Z.; Kowalska, I.; Kozak, D. B.; Krämer, C.; Kringel, V.; Krishnan, B.; Królak, A.; Kuehn, G.; Kumar, P.; Kumar, R.; Kumar, S.; Kuo, L.; Kutynia, A.; Kwang, S.; Lackey, B. D.; Lai, K. H.; Landry, M.; Lang, R. N.; Lange, J.; Lantz, B.; Lanza, R. K.; Lartaux-Vollard, A.; Lasky, P. D.; Laxen, M.; Lazzarini, A.; Lazzaro, C.; Leaci, P.; Leavey, S.; Lee, C. H.; Lee, H. K.; Lee, H. M.; Lee, H. W.; Lee, K.; Lehmann, J.; Lenon, A.; Leonardi, M.; Leroy, N.; Letendre, N.; Levin, Y.; Li, T. G. F.; Linker, S. D.; Liu, J.; Lo, R. K. L.; Lockerbie, N. A.; London, L. T.; Lord, J. E.; Lorenzini, M.; Loriette, V.; Lormand, M.; Losurdo, G.; Lough, J. D.; Lousto, C. O.; Lovelace, G.; Lück, H.; Lumaca, D.; Lundgren, A. P.; Lynch, R.; Ma, Y.; Macas, R.; Macfoy, S.; Machenschalk, B.; MacInnis, M.; Macleod, D. M.; Magaña Hernandez, I.; Magaña-Sandoval, F.; Magaña Zertuche, L.; Magee, R. M.; Majorana, E.; Maksimovic, I.; Man, N.; Mandic, V.; Mangano, V.; Mansell, G. L.; Manske, M.; Mantovani, M.; Marchesoni, F.; Marion, F.; Márka, S.; Márka, Z.; Markakis, C.; Markosyan, A. S.; Markowitz, A.; Maros, E.; Marquina, A.; Martelli, F.; Martellini, L.; Martin, I. W.; Martin, R. M.; Martynov, D. V.; Mason, K.; Massera, E.; Masserot, A.; Massinger, T. J.; Masso-Reid, M.; Mastrogiovanni, S.; Matas, A.; Matichard, F.; Matone, L.; Mavalvala, N.; Mazumder, N.; McCarthy, R.; McClelland, D. E.; McCormick, S.; McCuller, L.; McGuire, S. C.; McIntyre, G.; McIver, J.; McManus, D. J.; McNeill, L.; McRae, T.; McWilliams, S. T.; Meacher, D.; Meadors, G. D.; Mehmet, M.; Meidam, J.; Mejuto-Villa, E.; Melatos, A.; Mendell, G.; Mercer, R. A.; Merilh, E. L.; Merzougui, M.; Meshkov, S.; Messenger, C.; Messick, C.; Metzdorff, R.; Meyers, P. M.; Miao, H.; Michel, C.; Middleton, H.; Mikhailov, E. E.; Milano, L.; Miller, A. L.; Miller, B. B.; Miller, J.; Milovich-Goff, M. C.; Minazzoli, O.; Minenkov, Y.; Ming, J.; Mishra, C.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Moffa, D.; Moggi, A.; Mogushi, K.; Mohan, M.; Mohapatra, S. R. P.; Montani, M.; Moore, C. J.; Moraru, D.; Moreno, G.; Morriss, S. R.; Mours, B.; Mow-Lowry, C. M.; Mueller, G.; Muir, A. W.; Mukherjee, Arunava; Mukherjee, D.; Mukherjee, S.; Mukund, N.; Mullavey, A.; Munch, J.; Muñiz, E. A.; Muratore, M.; Murray, P. G.; Napier, K.; Nardecchia, I.; Naticchioni, L.; Nayak, R. K.; Neilson, J.; Nelemans, G.; Nelson, T. J. N.; Nery, M.; Neunzert, A.; Nevin, L.; Newport, J. M.; Newton, G.; Ng, K. K. Y.; Nguyen, T. T.; Nichols, D.; Nielsen, A. B.; Nissanke, S.; Nitz, A.; Noack, A.; Nocera, F.; Nolting, D.; North, C.; Nuttall, L. K.; Oberling, J.; O'Dea, G. D.; Ogin, G. H.; Oh, J. J.; Oh, S. H.; Ohme, F.; Okada, M. A.; Oliver, M.; Oppermann, P.; Oram, Richard J.; O'Reilly, B.; Ormiston, R.; Ortega, L. F.; O'Shaughnessy, R.; Ossokine, S.; Ottaway, D. J.; Overmier, H.; Owen, B. J.; Pace, A. E.; Page, J.; Page, M. A.; Pai, A.; Pai, S. A.; Palamos, J. R.; Palashov, O.; Palomba, C.; Pal-Singh, A.; Pan, Howard; Pan, Huang-Wei; Pang, B.; Pang, P. T. H.; Pankow, C.; Pannarale, F.; Pant, B. C.; Paoletti, F.; Paoli, A.; Papa, M. A.; Parida, A.; Parker, W.; Pascucci, D.; Pasqualetti, A.; Passaquieti, R.; Passuello, D.; Patil, M.; Patricelli, B.; Pearlstone, B. L.; Pedraza, M.; Pedurand, R.; Pekowsky, L.; Pele, A.; Penn, S.; Perez, C. J.; Perreca, A.; Perri, L. M.; Pfeiffer, H. P.; Phelps, M.; Phukon, K. S.; Piccinni, O. J.; Pichot, M.; Piergiovanni, F.; Pierro, V.; Pillant, G.; Pinard, L.; Pinto, I. M.; Pirello, M.; Pitkin, M.; Poe, M.; Poggiani, R.; Popolizio, P.; Porter, E. K.; Post, A.; Powell, J.; Prasad, J.; Pratt, J. W. W.; Pratten, G.; Predoi, V.; Prestegard, T.; Prijatelj, M.; Principe, M.; Privitera, S.; Prodi, G. A.; Prokhorov, L. G.; Puncken, O.; Punturo, M.; Puppo, P.; Pürrer, M.; Qi, H.; Quetschke, V.; Quintero, E. A.; Quitzow-James, R.; Raab, F. J.; Rabeling, D. S.; Radkins, H.; Raffai, P.; Raja, S.; Rajan, C.; Rajbhandari, B.; Rakhmanov, M.; Ramirez, K. E.; Ramos-Buades, A.; Rapagnani, P.; Raymond, V.; Razzano, M.; Read, J.; Regimbau, T.; Rei, L.; Reid, S.; Reitze, D. H.; Ren, W.; Reyes, S. D.; Ricci, F.; Ricker, P. M.; Rieger, S.; Riles, K.; Rizzo, M.; Robertson, N. A.; Robie, R.; Robinet, F.; Rocchi, A.; Rolland, L.; Rollins, J. G.; Roma, V. J.; Romano, R.; Romel, C. L.; Romie, J. H.; Rosińska, D.; Ross, M. P.; Rowan, S.; Rüdiger, A.; Ruggi, P.; Rutins, G.; Ryan, K.; Sachdev, S.; Sadecki, T.; Sadeghian, L.; Sakellariadou, M.; Salconi, L.; Saleem, M.; Salemi, F.; Samajdar, A.; Sammut, L.; Sampson, L. M.; Sanchez, E. J.; Sanchez, L. E.; Sanchis-Gual, N.; Sandberg, V.; Sanders, J. R.; Sarin, N.; Sassolas, B.; Sathyaprakash, B. S.; Saulson, P. R.; Sauter, O.; Savage, R. L.; Sawadsky, A.; Schale, P.; Scheel, M.; Scheuer, J.; Schmidt, J.; Schmidt, P.; Schnabel, R.; Schofield, R. M. S.; Schönbeck, A.; Schreiber, E.; Schuette, D.; Schulte, B. W.; Schutz, B. F.; Schwalbe, S. G.; Scott, J.; Scott, S. M.; Seidel, E.; Sellers, D.; Sengupta, A. S.; Sentenac, D.; Sequino, V.; Sergeev, A.; Shaddock, D. A.; Shaffer, T. J.; Shah, A. A.; Shahriar, M. S.; Shaner, M. B.; Shao, L.; Shapiro, B.; Shawhan, P.; Sheperd, A.; Shoemaker, D. H.; Shoemaker, D. M.; Siellez, K.; Siemens, X.; Sieniawska, M.; Sigg, D.; Silva, A. D.; Singer, L. P.; Singh, A.; Singhal, A.; Sintes, A. M.; Rana, J.; Slagmolen, B. J. J.; Smith, B.; Smith, J. R.; Smith, R. J. E.; Somala, S.; Son, E. J.; Sonnenberg, J. A.; Sorazu, B.; Sorrentino, F.; Souradeep, T.; Sowell, E.; Spencer, A. P.; Srivastava, A. K.; Staats, K.; Staley, A.; Steinke, M.; Steinlechner, J.; Steinlechner, S.; Steinmeyer, D.; Stevenson, S. P.; Stone, R.; Stops, D. J.; Strain, K. A.; Stratta, G.; Strigin, S. E.; Strunk, A.; Sturani, R.; Stuver, A. L.; Summerscales, T. Z.; Sun, L.; Sunil, S.; Suresh, J.; Sutton, P. J.; Swinkels, B. L.; Szczepańczyk, M. J.; Tacca, M.; Tait, S. C.; Talbot, C.; Talukder, D.; Tanner, D. B.; Tápai, M.; Taracchini, A.; Tasson, J. D.; Taylor, J. A.; Taylor, R.; Tewari, S. V.; Theeg, T.; Thies, F.; Thomas, E. G.; Thomas, M.; Thomas, P.; Thorne, K. A.; Thrane, E.; Tiwari, S.; Tiwari, V.; Tokmakov, K. V.; Toland, K.; Tonelli, M.; Tornasi, Z.; Torres-Forné, A.; Torrie, C. I.; Töyrä, D.; Travasso, F.; Traylor, G.; Trinastic, J.; Tringali, M. C.; Trozzo, L.; Tsang, K. W.; Tse, M.; Tso, R.; Tsukada, L.; Tsuna, D.; Tuyenbayev, D.; Ueno, K.; Ugolini, D.; Unnikrishnan, C. S.; Urban, A. L.; Usman, S. A.; Vahlbruch, H.; Vajente, G.; Valdes, G.; van Bakel, N.; van Beuzekom, M.; van den Brand, J. F. J.; Van Den Broeck, C.; Vander-Hyde, D. C.; van der Schaaf, L.; van Heijningen, J. V.; van Veggel, A. A.; Vardaro, M.; Varma, V.; Vass, S.; Vasúth, M.; Vecchio, A.; Vedovato, G.; Veitch, J.; Veitch, P. J.; Venkateswara, K.; Venugopalan, G.; Verkindt, D.; Vetrano, F.; Viceré, A.; Viets, A. D.; Vinciguerra, S.; Vine, D. J.; Vinet, J.-Y.; Vitale, S.; Vo, T.; Vocca, H.; Vorvick, C.; Vyatchanin, S. P.; Wade, A. R.; Wade, L. E.; Wade, M.; Walet, R.; Walker, M.; Wallace, L.; Walsh, S.; Wang, G.; Wang, H.; Wang, J. Z.; Wang, W. H.; Wang, Y. F.; Ward, R. L.; Warner, J.; Was, M.; Watchi, J.; Weaver, B.; Wei, L.-W.; Weinert, M.; Weinstein, A. J.; Weiss, R.; Wen, L.; Wessel, E. K.; Weßels, P.; Westerweck, J.; Westphal, T.; Wette, K.; Whelan, J. T.; White, D. D.; Whiting, B. F.; Whittle, C.; Wilken, D.; Williams, D.; Williams, R. D.; Williamson, A. R.; Willis, J. L.; Willke, B.; Wimmer, M. H.; Winkler, W.; Wipf, C. C.; Wittel, H.; Woan, G.; Woehler, J.; Wofford, J.; Wong, K. W. K.; Worden, J.; Wright, J. L.; Wu, D. S.; Wysocki, D. M.; Xiao, S.; Yamamoto, H.; Yancey, C. C.; Yang, L.; Yap, M. J.; Yazback, M.; Yu, Hang; Yu, Haocun; Yvert, M.; Zadrożny, A.; Zanolin, M.; Zelenova, T.; Zendri, J.-P.; Zevin, M.; Zhang, L.; Zhang, M.; Zhang, T.; Zhang, Y.-H.; Zhao, C.; Zhou, M.; Zhou, Z.; Zhu, S. J.; Zhu, X. J.; Zimmerman, A. B.; Zucker, M. E.; Zweizig, J.; (LIGO Scientific Collaboration; Virgo Collaboration

    2017-12-01

    The first observation of a binary neutron star (NS) coalescence by the Advanced LIGO and Advanced Virgo gravitational-wave (GW) detectors offers an unprecedented opportunity to study matter under the most extreme conditions. After such a merger, a compact remnant is left over whose nature depends primarily on the masses of the inspiraling objects and on the equation of state of nuclear matter. This could be either a black hole (BH) or an NS, with the latter being either long-lived or too massive for stability implying delayed collapse to a BH. Here, we present a search for GWs from the remnant of the binary NS merger GW170817 using data from Advanced LIGO and Advanced Virgo. We search for short- (≲1 s) and intermediate-duration (≲500 s) signals, which include GW emission from a hypermassive NS or supramassive NS, respectively. We find no signal from the post-merger remnant. Our derived strain upper limits are more than an order of magnitude larger than those predicted by most models. For short signals, our best upper limit on the root sum square of the GW strain emitted from 1-4 kHz is {h}{rss}50 % =2.1× {10}-22 {{Hz}}-1/2 at 50% detection efficiency. For intermediate-duration signals, our best upper limit at 50% detection efficiency is {h}{rss}50 % =8.4× {10}-22 {{Hz}}-1/2 for a millisecond magnetar model, and {h}{rss}50 % =5.9× {10}-22 {{Hz}}-1/2 for a bar-mode model. These results indicate that post-merger emission from a similar event may be detectable when advanced detectors reach design sensitivity or with next-generation detectors.

  14. Detection of explosive remnants of war by neutron thermalisation

    Energy Technology Data Exchange (ETDEWEB)

    Brooks, F.D., E-mail: frank.brooks@uct.ac.za [Department of Physics, University of Cape Town, Rondebosch 7701 (South Africa); Drosg, M. [Faculty of Physics, University of Vienna, Wien A-1090 (Austria); Smit, F.D.; Wikner, C. [iThemba Laboratory for Accelerator-Based Sciences, Somerset West 7129 (South Africa)

    2012-01-15

    The HYDAD-D landmine detector () has been modified and field-tested for 17 months in a variety of soil conditions. Test objects containing about the same mass of hydrogen (20 g) as small explosive remnants of war, such as antipersonnel landmines, were detected with efficiency 100% when buried at cover depths up to 10 cm. The false alarm rate under the same conditions was 9%. Plots of detection efficiency versus false alarm rate are presented. - Highlights: Black-Right-Pointing-Pointer A new version of the HYDAD-D antipersonnel landmine detector is described. Black-Right-Pointing-Pointer Field tests were carried out for 17 months under different conditions. Black-Right-Pointing-Pointer Dummy antipersonnel mines were detected with 100% efficiency at cover depths up to 10 cm. Black-Right-Pointing-Pointer Results are presented as plots of landmine detection efficiency versus false alarm rate.

  15. Compact binary merger and kilonova: outflows from remnant disc

    Science.gov (United States)

    Yi, Tuan; Gu, Wei-Min; Liu, Tong; Kumar, Rajiv; Mu, Hui-Jun; Song, Cui-Ying

    2018-05-01

    Outflows launched from a remnant disc of compact binary merger may have essential contribution to the kilonova emission. Numerical calculations are conducted in this work to study the structure of accretion flows and outflows. By the incorporation of limited-energy advection in the hyper-accretion discs, outflows occur naturally from accretion flows due to imbalance between the viscous heating and the sum of the advective and radiative cooling. Following this spirit, we revisit the properties of the merger outflow ejecta. Our results show that around 10-3 ˜ 10-1 M⊙ of the disc mass can be launched as powerful outflows. The amount of unbound mass varies with the disc mass and the viscosity. The outflow-contributed peak luminosity is around 1040 ˜ 1041 erg s-1. Such a scenario can account for the observed kilonovae associated with short gamma-ray bursts, including the recent event AT2017gfo (GW170817).

  16. Shocked molecular hydrogen in the supernova remnant IC 443

    International Nuclear Information System (INIS)

    Burton, M.G.; Brand, P.W.J.L.; Webster, A.S.

    1988-01-01

    Emission from the υ = 1-0 S(1) line of molecular hydrogen has been mapped over a section of the supernova remnant IC 443. The emission originates in a sinuous ridge where the expanding shell of the SNR is interacting with a molecular cloud. The relative intensities of the 1-0 S(1), 1-0 S(0) and 2-1 S(1) lines at 2.1-2.2 μm were measured and found to be characteristic of shock-excitation of the gas. The ridge shows bright spots which are possibly density enhancements in the molecular cloud. The total luminosity of the molecular hydrogen lines in the mapped region is estimated to be about 1000 times the solar luminosity, making IC 443 one of the most luminous galactic molecular hydrogen sources yet detected. (author)

  17. New selection effect of statistical investigations of supernova remnants

    International Nuclear Information System (INIS)

    Allakhverdiev, A.O.; Gusejnov, O.Kh.; Kasumov, F.K.

    1986-01-01

    The influence of H2 regions on the parameters of Supernova remnants (SNR) is investigated. It has been shown that the projection of such regions on the SNRs leads to local changes of morphological structure of young shell-type SNRs and considerable distortions of integral parameters of evolved shell-type SNRs (with D > 10 pc) and plerions, up to their complete undetectability on the background of classical and gigantic H2 regions. A new selection effect, in fact, arises from these factors connected with additional limitations made by the real structure of the interstellar medium on the statistical investigations of SNRs. The influence of this effect on the statistical completeness of objects has been estimated

  18. New selection effect in statistical investigations of supernova remnants

    Science.gov (United States)

    Allakhverdiev, A. O.; Guseinov, O. Kh.; Kasumov, F. K.

    1986-01-01

    The influence of H II regions on the parameters of supernova remnants (SNR) is investigated. It has been shown that the projection of such regions on the SNRs leads to: a) local changes of morphological structure of young shell-type SNRs and b) considerable distortions of integral parameters of evolved shell-type SNRs (with D > 10 pc) and plerions, up to their complete undetectability on the background of classical and gigantic H II regions. A new selection effect, in fact, arises from these factors connected with additional limitations made by the real structure of the interstellar medium on the statistical investigations of SNRs. The influence of this effect on the statistical completeness of objects has been estimated.

  19. Grain Destruction in a Supernova Remnant Shock Wave

    Science.gov (United States)

    Raymond, John C.; Ghavamian, Parviz; Williams, Brian J.; Blair, William P.; Borkowski, Kazimierz J.; Gaetz, Terrance J.; Sankrit, Ravi

    2014-01-01

    Dust grains are sputtered away in the hot gas behind shock fronts in supernova remnants, gradually enriching the gas phase with refractory elements. We have measured emission in C IV (lambda)1550 from C atoms sputtered from dust in the gas behind a non-radiative shock wave in the northern Cygnus Loop. Overall, the intensity observed behind the shock agrees approximately with predictions from model calculations that match the Spitzer 24 micron and the X-ray intensity profiles. Thus these observations confirm the overall picture of dust destruction in SNR shocks and the sputtering rates used in models. However, there is a discrepancy in that the CIV intensity 10'' behind the shock is too high compared to the intensities at the shock and 25'' behind it. Variations in the density, hydrogen neutral fraction and the dust properties over parsec scales in the pre- shock medium limit our ability to test dust destruction models in detail.

  20. Approximate supernova remnant dynamics with cosmic ray production

    International Nuclear Information System (INIS)

    Voelk, H.J.; Drury, L.O.; Dorfi, E.A.

    1985-01-01

    Supernova explosions are the most violent and energetic events in the galaxy and have long been considered probable sources of cosmic rays. Recent shock acceleration models treating the cosmic rays (CR's) as test particles nb a prescribed supernova remnant (SNR) evolution, indeed indicate an approximate power law momentum distribution f sub source (p) approximation p(-a) for the particles ultimately injected into the interstellar medium (ISM). This spectrum extends almost to the momentum p = 1 million GeV/c, where the break in the observed spectrum occurs. The calculated power law index approximately less than 4.2 agrees with that inferred for the galactic CR sources. The absolute CR intensity can however not be well determined in such a test particle approximation

  1. Approximate supernova remnant dynamics with cosmic ray production

    Science.gov (United States)

    Voelk, H. J.; Drury, L. O.; Dorfi, E. A.

    1985-01-01

    Supernova explosions are the most violent and energetic events in the galaxy and have long been considered probably sources of Cosmic Rays. Recent shock acceleration models treating the Cosmic Rays (CR's) as test particles nb a prescribed Supernova Remnant (SNR) evolution, indeed indicate an approximate power law momentum distribution f sub source (p) approximation p(-a) for the particles ultimately injected into the Interstellar Medium (ISM). This spectrum extends almost to the momentum p = 1 million GeV/c, where the break in the observed spectrum occurs. The calculated power law index approximately less than 4.2 agrees with that inferred for the galactic CR sources. The absolute CR intensity can however not be well determined in such a test particle approximation.

  2. Diffuse remnants of supernova explosions of moving massive stars

    Science.gov (United States)

    Gvaramadze, V. V.

    The modification of the ambient interstellar medium by the wind of massive stars (the progenitors of most of supernovae) results in that the structure and evolution of diffuse supernova remnants (SNRs) significantly deviate from those derived from standard models of SNRs based of the Sedov-Taylor solution. The stellar proper motion and the regular interstellar magnetic field affect the symmetry of the processed medium and cause the SNR to be non-spherically-symmetric. We show that taking into account these effects allows us to explain the diverse morphologies of the known SNRs (the particular attention is paid to the elongated axisymmetric SNRs and the SNRs consisting of two partially overlapping shells) and to infer the ``true" supernova explosion sites in some peculiar SNRs (therefore to search for new neutron stars associated with them).

  3. Remnants of black rings from gravity’s rainbow

    Energy Technology Data Exchange (ETDEWEB)

    Ali, Ahmed Farag [Center for Fundamental Physics, Zewail City of Science and Technology,6th of October City, Giza 12588 (Egypt); Department of Physics, Faculty of Science, Benha University,Benha 13518 (Egypt); Faizal, Mir [Department of Physics and Astronomy, University of Waterloo,Waterloo, Ontario, N2L 3G1 (Canada); Khalil, Mohammed M. [Department of Electrical Engineering, Alexandria University,El-Horreya Rd., Alexandria 12544 (Egypt)

    2014-12-29

    In this paper, we investigate a spinning black ring and a charged black ring in the context of gravity’s rainbow. By incorporating rainbow functions proposed by Amelino-Camelia, et al. in http://dx.doi.org/10.1142/S0217751X97000566 http://dx.doi.org/10.12942/lrr-2013-5 in the metric of the black rings, a considerable modification happens to their thermodynamical properties. We calculate corrections to the temperature, entropy and heat capacity of the black rings. These calculations demonstrate that the behavior of Hawking radiation changes considerably near the Planck scale in gravity’s rainbow, where it is shown that black rings do not evaporate completely and a remnant is left as the black rings evaporate down to Planck scale.

  4. Supernova remnant W49B and its environment

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, H.; Tian, W. W.; Zuo, P., E-mail: zhuhui@bao.ac.cn, E-mail: tww@bao.ac.cn [Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 (China)

    2014-10-01

    We study gamma-ray supernova remnant (SNR) W49B and its environment using recent radio and infrared data. Spitzer Infrared Spectrograph low resolution data of W49B shows shocked excitation lines of H{sub 2} (0,0) S(0)-S(7) from the SNR-molecular cloud interaction. The H{sub 2} gas is composed of two components with temperatures of ∼260 K and ∼1060 K, respectively. Various spectral lines from atomic and ionic particles are detected toward W49B. We suggest that the ionic phase has an electron density of ∼500 cm{sup –3} and a temperature of ∼10{sup 4} K by the spectral line diagnoses. The mid- and far-infrared data from MSX, Spitzer, and Herschel reveal a 151 ± 20 K hot dust component with a mass of 7.5 ± 6.6 × 10{sup –4} M {sub ☉} and a 45 ± 4 K warm dust component with a mass of 6.4 ± 3.2 M {sub ☉}. The hot dust is likely from materials swept up by the shock of W49B. The warm dust may possibly originate from the evaporation of clouds interacting with W49B. We build the H I absorption spectra of W49B and four nearby H II regions (W49A, G42.90+0.58, G42.43-0.26, and G43.19-0.53) and study the relation between W49B and the surrounding molecular clouds by employing the 2.12 μm infrared and CO data. We therefore obtain a kinematic distance of ∼10 kpc for W49B and suggest that the remnant is likely associated with the CO cloud at about 40 km s{sup –1}.

  5. Functional and morphological changes in pancreatic remnant after pancreaticoduodenectomy.

    Science.gov (United States)

    Fang, Wen-Liang; Su, Cheng-Hsi; Shyr, Yi-Ming; Chen, Tien-Hua; Lee, Rheun-Chuan; Tai, Ling-Chen; Wu, Chew-Wun; Lui, Wing-Yiu

    2007-11-01

    Pancreatic exocrine insufficiency has been reported to be more common in pancreaticogastrostomy (PG) than in pancreaticojejunostomy (PJ) after pancreaticoduodenectomy (PD). This study aimed to evaluate the long-term outcome after PD between these 2 groups. We evaluated the long-term functional status of 42 surviving patients diagnosed with periampullary lesions who underwent PJ or PG after PD and followed up for more than 1 year. Among these, 23 patients underwent PJ and 19 patients underwent PG. To compare the 2 groups, we analyzed the (1) pancreatic exocrine insufficiency by questioning the presence or absence of steatorrhea, (2) pancreatic endocrine function by measuring glycohemoglobin A1c, fasting blood glucose, and history of new-onset diabetes, (3) nutritional status by measuring serum total protein, albumin, cholesterol, and triglyceride, (4) gastric emptying time, (5) panendoscopic findings, (6) changes of pancreatic duct diameter by computed tomography, and (7) relaparotomy rate. The mean follow-up time for PG and PJ were 37 +/- 23 and 103 +/- 52 months, respectively (P pancreatic exocrine insufficiency, and 11.9% had new-onset diabetes. There was no significant difference between PJ and PG groups. A significantly improved postoperative nutritional state regarding serum total protein and albumin were noticed in both groups. There was no significant difference in terms of gastric emptying time, positive panendoscopic findings, and changes in pancreatic duct diameter. The pancreatic remnant-related relaparotomy rate was higher in the PJ group as compared with the PG group (17.4% vs 0%; P = 0.056). There is no significant difference in pancreatic exocrine or endocrine insufficiency, gastric emptying time, and positive panendoscopic findings between PJ and PG. Pancreaticojejunostomy was associated with a higher pancreatic remnant-related relaparotomy rate; however, because of a shorter follow-up in the PG group, a continuous long-term follow-up is still

  6. Hubble Space Telescope Image, Supernova Remnant Cassiopeia A

    Science.gov (United States)

    2000-01-01

    The colorful streamers that float across the sky in this photo taken by NASA's Hubble Space Telescope (HST) were created by the universe's biggest firecracker, the titanic supernova explosion of a massive star. The light from the exploding star reached Earth 320 years ago, nearly a century before the United States celebrated its birth with a bang. The dead star's shredded remains are called Cassiopeia A, or 'Cas A' for short. Cas A is the youngest known supernova remnant in our Milky Way Galaxy and resides 10,000 light-years away in the constellation Cassiopeia, so the star actually blew up 10,000 years before the light reached Earth in the late 1600s. This HST image of Cas A shows for the first time that the debris is arranged into thousands of small, cooling knots of gas. This material eventually will be recycled into building new generations of stars and planets. Our own Sun and planets are constructed from the debris of supernovae that exploded billions of years ago. This photo shows the upper rim of the super nova remnant's expanding shell. Near the top of the image are dozens of tiny clumps of matter. Each small clump, originally just a small fragment of the star, is tens of times larger than the diameter of our solar system. The colors highlight parts of the debris where chemical elements are glowing. The dark blue fragments, for example, are richest in oxygen; the red material is rich in sulfur. The images were taken with the Wide Field and Planetary Camera 2 in January 2000 and January 2002. Image Credit: NASA and HST team (Stoics/AURA). Acknowledgment: R. Fesen (Darmouth) and J. Morse ( Univ. of Colorado).

  7. POPULATION III STARS AND REMNANTS IN HIGH-REDSHIFT GALAXIES

    International Nuclear Information System (INIS)

    Xu Hao; Norman, Michael L.; Wise, John H.

    2013-01-01

    Recent simulations of Population III star formation have suggested that some fraction form in binary systems, in addition to having a characteristic mass of tens of solar masses. The deaths of metal-free stars result in the initial chemical enrichment of the universe and the production of the first stellar-mass black holes. Here we present a cosmological adaptive mesh refinement simulation of an overdense region that forms a few 10 9 M ☉ dark matter halos and over 13,000 Population III stars by redshift 15. We find that most halos do not form Population III stars until they reach M vir ∼ 10 7 M ☉ because this biased region is quickly enriched from both Population III and galaxies, which also produce high levels of ultraviolet radiation that suppress H 2 formation. Nevertheless, Population III stars continue to form, albeit in more massive halos, at a rate of ∼10 –4 M ☉ yr –1 Mpc –3 at redshift 15. The most massive starless halo has a mass of 7 × 10 7 M ☉ , which could host massive black hole formation through the direct gaseous collapse scenario. We show that the multiplicity of the Population III remnants grows with halo mass above 10 8 M ☉ , culminating in 50 remnants located in 10 9 M ☉ halos on average. This has implications that high-mass X-ray binaries and intermediate-mass black holes that originate from metal-free stars may be abundant in high-redshift galaxies

  8. Search and modelling of remnant radio galaxies in the LOFAR Lockman Hole field

    NARCIS (Netherlands)

    Brienza, M.; Godfrey, L.; Morganti, R.; Prandoni, I.; Harwood, J.; Mahony, E. K.; Hardcastle, M. J.; Murgia, M.; Röttgering, H. J. A.; Shimwell, T. W.; Shulevski, A.

    2017-01-01

    Context. The phase of radio galaxy evolution after the jets have switched off, often referred to as the remnant phase, is poorly understood and very few sources in this phase are known. Aims: In this work we present an extensive search for remnant radio galaxies in the Lockman Hole, a well-studied

  9. Semiparametric Power Envelopes for Tests of the Unit Root Hypothesis

    DEFF Research Database (Denmark)

    Jansson, Michael

    This paper derives asymptotic power envelopes for tests of the unit root hypothesis in a zero-mean AR(1) model. The power envelopes are derived using the limits of experiments approach and are semiparametric in the sense that the underlying error distribution is treated as an unknown...

  10. Full waveform inversion using envelope-based global correlation norm

    Science.gov (United States)

    Oh, Ju-Won; Alkhalifah, Tariq

    2018-05-01

    To increase the feasibility of full waveform inversion on real data, we suggest a new objective function, which is defined as the global correlation of the envelopes of modelled and observed data. The envelope-based global correlation norm has the advantage of the envelope inversion that generates artificial low-frequency information, which provides the possibility to recover long-wavelength structure in an early stage. In addition, the envelope-based global correlation norm maintains the advantage of the global correlation norm, which reduces the sensitivity of the misfit to amplitude errors so that the performance of inversion on real data can be enhanced when the exact source wavelet is not available and more complex physics are ignored. Through the synthetic example for 2-D SEG/EAGE overthrust model with inaccurate source wavelet, we compare the performance of four different approaches, which are the least-squares waveform inversion, least-squares envelope inversion, global correlation norm and envelope-based global correlation norm. Finally, we apply the envelope-based global correlation norm on the 3-D Ocean Bottom Cable (OBC) data from the North Sea. The envelope-based global correlation norm captures the strong reflections from the high-velocity caprock and generates artificial low-frequency reflection energy that helps us recover long-wavelength structure of the model domain in the early stages. From this long-wavelength model, the conventional global correlation norm is sequentially applied to invert for higher-resolution features of the model.

  11. Calculation of CWKB envelope in boson and fermion productions

    Indian Academy of Sciences (India)

    Abstract. We present the calculation of envelope of boson and of both low- and high- mass fermion production at the end of inflation when the coherently oscillating inflatons decay into bosons and fermions. We consider three different models of inflation and use. CWKB technique to calculate the envelope to understand the ...

  12. 14 CFR 29.1517 - Limiting height-speed envelope.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Limiting height-speed envelope. 29.1517... Operating Limitations § 29.1517 Limiting height-speed envelope. For Category A rotorcraft, if a range of... following power failure, the range of heights and its variation with forward speed must be established...

  13. Beam envelope profile of non-centrosymmetric polygonal phase space

    International Nuclear Information System (INIS)

    Chen Yinbao; Xie Xi

    1984-01-01

    The general theory of beam envelope profile of non-centrosymmetric polygonal phase space is developed. By means of this theory the beam envelope profile of non-centrosymmetric polygonal phase space can be calculated directly. An example is carried out in detail to show the practical application of the theory

  14. Effect of Hashimoto thyroiditis on low-dose radioactive-iodine remnant ablation.

    Science.gov (United States)

    Kwon, Hyungju; Choi, June Young; Moon, Jae Hoon; Park, Hyo Jin; Lee, Won Woo; Lee, Kyu Eun

    2016-04-01

    Radioactive-iodine remnant ablation is an integral part of the papillary thyroid carcinoma (PTC) treatment. Although a minimum dose is usually recommended, there is controversy as to whether the low-dose (1100 MBq) radioactive-iodine remnant ablation is adequate for selected patients. A retrospective cohort study was conducted on 691 patients. Patients with no remnant thyroid on the follow-up whole body scan and low stimulated thyroglobulin (sTg) level (Hashimoto thyroiditis based on histopathology diagnosis (odds ratio [OR] = 3.23; p Hashimoto thyroiditis and elevated sTg are negative predictive factors for successful low-dose radioactive-iodine remnant ablation treatment. An appropriate risk-adjusted approach may improve the efficacy of radioactive-iodine remnant ablation treatment. © 2015 Wiley Periodicals, Inc. Head Neck 38: E730-E735, 2016. © 2015 Wiley Periodicals, Inc.

  15. Remnant Cholesterol Elicits Arterial Wall Inflammation and a Multilevel Cellular Immune Response in Humans

    DEFF Research Database (Denmark)

    Bernelot Moens, Sophie J; Verweij, Simone L; Schnitzler, Johan G

    2017-01-01

    cholesterol accumulates in human hematopoietic stem and progenitor cells coinciding with myeloid skewing. CONCLUSIONS: Patients with FD have increased arterial wall and cellular inflammation. These findings imply an important inflammatory component to the atherogenicity of remnant cholesterol, contributing......OBJECTIVE: Mendelian randomization studies revealed a causal role for remnant cholesterol in cardiovascular disease. Remnant particles accumulate in the arterial wall, potentially propagating local and systemic inflammation. We evaluated the impact of remnant cholesterol on arterial wall...... inflammation, circulating monocytes, and bone marrow in patients with familial dysbetalipoproteinemia (FD). APPROACH AND RESULTS: Arterial wall inflammation and bone marrow activity were measured using 18F-FDG PET/CT. Monocyte phenotype was assessed with flow cytometry. The correlation between remnant levels...

  16. A Spectral Algorithm for Envelope Reduction of Sparse Matrices

    Science.gov (United States)

    Barnard, Stephen T.; Pothen, Alex; Simon, Horst D.

    1993-01-01

    The problem of reordering a sparse symmetric matrix to reduce its envelope size is considered. A new spectral algorithm for computing an envelope-reducing reordering is obtained by associating a Laplacian matrix with the given matrix and then sorting the components of a specified eigenvector of the Laplacian. This Laplacian eigenvector solves a continuous relaxation of a discrete problem related to envelope minimization called the minimum 2-sum problem. The permutation vector computed by the spectral algorithm is a closest permutation vector to the specified Laplacian eigenvector. Numerical results show that the new reordering algorithm usually computes smaller envelope sizes than those obtained from the current standard algorithms such as Gibbs-Poole-Stockmeyer (GPS) or SPARSPAK reverse Cuthill-McKee (RCM), in some cases reducing the envelope by more than a factor of two.

  17. Infectious Entry Pathway Mediated by the Human Endogenous Retrovirus K Envelope Protein.

    Science.gov (United States)

    Robinson, Lindsey R; Whelan, Sean P J

    2016-01-20

    Endogenous retroviruses (ERVs), the majority of which exist as degraded remnants of ancient viruses, comprise approximately 8% of the human genome. The youngest human ERVs (HERVs) belong to the HERV-K(HML-2) subgroup and were endogenized within the past 1 million years. The viral envelope protein (ENV) facilitates the earliest events of endogenization (cellular attachment and entry), and here, we characterize the requirements for HERV-K ENV to mediate infectious cell entry. Cell-cell fusion assays indicate that a minimum of two events are required for fusion, proteolytic processing by furin-like proteases and exposure to acidic pH. We generated an infectious autonomously replicating recombinant vesicular stomatitis virus (VSV) in which the glycoprotein was replaced by HERV-K ENV. HERV-K ENV imparts an endocytic entry pathway that requires dynamin-mediated membrane scission and endosomal acidification but is distinct from clathrin-dependent or macropinocytic uptake pathways. The lack of impediments to the replication of the VSV core in eukaryotic cells allowed us to broadly survey the HERV-K ENV-dictated tropism. Unlike extant betaretroviral envelopes, which impart a narrow species tropism, we found that HERV-K ENV mediates broad tropism encompassing cells from multiple mammalian and nonmammalian species. We conclude that HERV-K ENV dictates an evolutionarily conserved entry pathway and that the restriction of HERV-K to primate genomes reflects downstream stages of the viral replication cycle. Approximately 8% of the human genome is of retroviral origin. While many of those viral genomes have become inactivated, some copies of the most recently endogenized human retrovirus, HERV-K, can encode individual functional proteins. Here, we characterize the envelope protein (ENV) of the virus to define how it mediates infection of cells. We demonstrate that HERV-K ENV undergoes a proteolytic processing step and triggers membrane fusion in response to acidic pH--a strategy

  18. Dysfunction of bovine endogenous retrovirus K2 envelope glycoprotein is related to unsuccessful intracellular trafficking.

    Science.gov (United States)

    Nakaya, Yuki; Miyazawa, Takayuki

    2014-06-01

    Endogenous retroviruses (ERVs) are the remnants of retroviral infection of ancestral germ cells. Mutations introduced into ERVs halt the production of infectious agents, but their effects on the function of retroviral proteins are not fully understood. Retroviral envelope glycoproteins (Envs) are utilized in membrane fusion during viral entry, and we recently identified intact coding sequences for bovine endogenous retrovirus K1 (BERV-K1) and BERV-K2 Envs. Amino acid sequences of BERV-K1 Env (also called Fematrin-1) and BERV-K2 Env are similar, and both viruses are classified in the genus Betaretrovirus. While Fematrin-1 plays an important role in cell-to-cell fusion in bovine placenta, the BERV-K2 envelope gene is marginally expressed in vivo, and its recombinant Env protein is defective in membrane fusion due to inefficient cleavage of surface (SU) and transmembrane subunits. Here, we conducted chimeric analyses of Fematrin-1 and BERV-K2 Envs and revealed that defective maturation of BERV-K2 Env contributed to failed intracellular trafficking. Fluorescence microscopy and flow cytometric analysis suggested that in contrast to Fematrin-1 Env, BERV-K2 Env could not be transported from the endoplasmic reticulum to the trans-Golgi network, where cellular proteases required for processing retroviral Envs are localized. We also identified that one of the responsive regions of this phenomenon resided within a 65-amino-acid region of BERV-K2 SU. This is the first report to identify that retroviral Env SU is involved in the regulation of intracellular trafficking, and it may help to elucidate the maturation process of Fematrin-1 and other related Envs. Retroviruses utilize envelope glycoproteins (Envs) to enter host target cells. Mature retroviral Env is a heterodimer, which consists of surface (SU) and transmembrane (TM) subunits that are generated by the cleavage of an Env precursor protein in the trans-Golgi network. SU and TM mediate the recognition of the entry

  19. Envelope enhancement increases cortical sensitivity to interaural envelope delays with acoustic and electric hearing.

    Directory of Open Access Journals (Sweden)

    Douglas E H Hartley

    Full Text Available Evidence from human psychophysical and animal electrophysiological studies suggests that sensitivity to interaural time delay (ITD in the modulating envelope of a high-frequency carrier can be enhanced using half-wave rectified stimuli. Recent evidence has shown potential benefits of equivalent electrical stimuli to deaf individuals with bilateral cochlear implants (CIs. In the current study we assessed the effects of envelope shape on ITD sensitivity in the primary auditory cortex of normal-hearing ferrets, and profoundly-deaf animals with bilateral CIs. In normal-hearing animals, cortical sensitivity to ITDs (±1 ms in 0.1-ms steps was assessed in response to dichotically-presented i sinusoidal amplitude-modulated (SAM and ii half-wave rectified (HWR tones (100-ms duration; 70 dB SPL presented at the best-frequency of the unit over a range of modulation frequencies. In separate experiments, adult ferrets were deafened with neomycin administration and bilaterally-implanted with intra-cochlear electrode arrays. Electrically-evoked auditory brainstem responses (EABRs were recorded in response to bipolar electrical stimulation of the apical pair of electrodes with singe biphasic current pulses (40 µs per phase over a range of current levels to measure hearing thresholds. Subsequently, we recorded cortical sensitivity to ITDs (±800 µs in 80-µs steps within the envelope of SAM and HWR biphasic-pulse trains (40 µs per phase; 6000 pulses per second, 100-ms duration over a range of modulation frequencies. In normal-hearing animals, nearly a third of cortical neurons were sensitive to envelope-ITDs in response to SAM tones. In deaf animals with bilateral CI, the proportion of ITD-sensitive cortical neurons was approximately a fifth in response to SAM pulse trains. In normal-hearing and deaf animals with bilateral CI the proportion of ITD sensitive units and neural sensitivity to ITDs increased in response to HWR, compared with SAM stimuli

  20. Nuclear γ-tubulin associates with nucleoli and interacts with tumor suppressor protein C53.

    Science.gov (United States)

    Hořejší, Barbora; Vinopal, Stanislav; Sládková, Vladimíra; Dráberová, Eduarda; Sulimenko, Vadym; Sulimenko, Tetyana; Vosecká, Věra; Philimonenko, Anatoly; Hozák, Pavel; Katsetos, Christos D; Dráber, Pavel

    2012-01-01

    γ-Tubulin is assumed to be a typical cytosolic protein necessary for nucleation of microtubules from microtubule organizing centers. Using immunolocalization and cell fractionation techniques in combination with siRNAi and expression of FLAG-tagged constructs, we have obtained evidence that γ-tubulin is also present in nucleoli of mammalian interphase cells of diverse cellular origins. Immunoelectron microscopy has revealed γ-tubulin localization outside fibrillar centers where transcription of ribosomal DNA takes place. γ-Tubulin was associated with nucleolar remnants after nuclear envelope breakdown and could be translocated to nucleoli during mitosis. Pretreatment of cells with leptomycin B did not affect the distribution of nuclear γ-tubulin, making it unlikely that rapid active transport via nuclear pores participates in the transport of γ-tubulin into the nucleus. This finding was confirmed by heterokaryon assay and time-lapse imaging of photoconvertible protein Dendra2 tagged to γ-tubulin. Immunoprecipitation from nuclear extracts combined with mass spectrometry revealed an association of γ-tubulin with tumor suppressor protein C53 located at multiple subcellular compartments including nucleoli. The notion of an interaction between γ-tubulin and C53 was corroborated by pull-down and co-immunoprecipitation experiments. Overexpression of γ-tubulin antagonized the inhibitory effect of C53 on DNA damage G(2) /M checkpoint activation. The combined results indicate that aside from its known role in microtubule nucleation, γ-tubulin may also have nuclear-specific function(s). Copyright © 2011 Wiley Periodicals, Inc.

  1. ELECTRICALLY CONDUCTIVE OF NANOCOMPOSITES FOR SYSTEMS DIAGNOSTICS OF THE ENVELOPE WALLS TECHNICAL CONDITION OF NPP

    Directory of Open Access Journals (Sweden)

    BOLSHAKOV V. I.

    2016-05-01

    Full Text Available Raising of the problem. Enveloped concrete wall type structures of localizing safety systems for restaint and localization of radioactive decay products or in the case of special natural or man-made impacts on the power unit is one of the most important components to ensure the safety of nuclear power. The promising direction for the development of the NPP technical system monitoring is to use conductive nanocomposites as primary elements of information. The purpose of the article is to review the theoretical background and experience in the conductive nanocomposites creating for diagnostics of localizing nuclear safety systems. Conclusions. A promising area for the development of diagnostic systems of localizing nuclear safety systems is the use of electrically conductive nanocomposites (conductive concrete - bethels, plasters, paint coatings. A mechanism for conductive nanocomposites creating is the use of the filler metal and carbon nanoparticles. As binders is promising to use nanocomposites of the mineral binders (cement and water glass.

  2. X-Ray Emission from a Merger Remnant, NGC 7252 (the ``Atoms-for-Peace'' Galaxy)

    Science.gov (United States)

    Awaki, Hisamitsu; Matsumoto, Hironori; Tomida, Hiroshi

    2002-03-01

    We observed a nearby merger remnant NGC 7252 with the X-ray satellite ASCA and detected X-ray emission with the X-ray flux of (1.8+/-0.3)×10-13 ergs s-1 cm-2 in the 0.5-10 keV band. This corresponds to the X-ray luminosity of 8.1×1040 ergs s-1. The X-ray emission is well described with a two-component model: a soft component with kT=0.72+/-0.13 keV and a hard component with kT>5.1 keV. Although NGC 7252 is referred to as a dynamically young protoelliptical, the 0.5-4 keV luminosity of the soft component is about 2×1040 ergs s-1, which is low for an early-type galaxy. The ratio of LX/LFIR suggests that the soft component originated from the hot gas due to star formation. Its low luminosity can be explained by the gas ejection from the galaxy as galaxy winds. Our observation reveals the existence of hard X-ray emission with the 2-10 keV luminosity of 5.6×1040 ergs s-1. This may indicate the existence of nuclear activity or an intermediate-mass black hole in NGC 7252.

  3. Intermediate-mass Elements in Young Supernova Remnants Reveal Neutron Star Kicks by Asymmetric Explosions

    Science.gov (United States)

    Katsuda, Satoru; Morii, Mikio; Janka, Hans-Thomas; Wongwathanarat, Annop; Nakamura, Ko; Kotake, Kei; Mori, Koji; Müller, Ewald; Takiwaki, Tomoya; Tanaka, Masaomi; Tominaga, Nozomu; Tsunemi, Hiroshi

    2018-03-01

    The birth properties of neutron stars (NSs) yield important information about the still-debated physical processes that trigger the explosion as well as on intrinsic neutron-star physics. These properties include the high space velocities of young neutron stars with average values of several 100 km s‑1, with an underlying “kick” mechanism that is not fully clarified. There are two competing possibilities that could accelerate NSs during their birth: anisotropic ejection of either stellar debris or neutrinos. Here we present new evidence from X-ray measurements that chemical elements between silicon and calcium in six young gaseous supernova remnants are preferentially expelled opposite to the direction of neutron star motion. There is no correlation between the kick velocities and magnetic field strengths of these neutron stars. Our results support a hydrodynamic origin of neutron-star kicks connected to asymmetric explosive mass ejection, and they conflict with neutron-star acceleration scenarios that invoke anisotropic neutrino emission caused by particle and nuclear physics in combination with very strong neutron-star magnetic fields.

  4. THE NATURE OF GAMMA-RAY EMISSION OF TYCHO'S SUPERNOVA REMNANT

    International Nuclear Information System (INIS)

    Berezhko, E. G.; Ksenofontov, L. T.; Völk, H. J.

    2013-01-01

    The nature of the recently detected high-energy and very high-energy γ-ray emission of Tycho's supernova remnant (SNR) is studied. A nonlinear kinetic theory of cosmic-ray (CR) acceleration in SNRs is employed to investigate the properties of Tycho's SNR and their correspondence with the existing experimental data, taking into account that the ambient interstellar medium (ISM) is expected to be clumpy. It is demonstrated that the overall steep γ-ray spectrum observed can be interpreted as the superposition of two spectra produced by the CR proton component in two different ISM phases: the first γ-ray component, extending up to about 10 14 eV, originates in the diluted warm ISM, whereas the second component, extending up to 100 GeV, comes from numerous dense, small-scale clouds embedded in this warm ISM. Given the consistency between acceleration theory and the observed properties of the nonthermal emission of Tycho's SNR, very efficient production of nuclear CRs in Tycho's SNR is established. The excess of the GeV γ-ray emission due to the clouds' contribution above the level expected in the case of a purely homogeneous ISM is inevitably expected in the case of Type Ia SNe.

  5. Selecting Energy Efficient Building Envelope Retrofits to Existing Department of Defense Building Using Value Focused Thinking

    National Research Council Canada - National Science Library

    Pratt, David M

    2006-01-01

    ... these facilities that have the greatest potential for energy efficient building envelope retrofits. There are hundreds of various new building envelope technologies available to retrofit an existing building envelope, including window, roof, and wall technologies...

  6. The limited role of recombination energy in common envelope removal

    Science.gov (United States)

    Grichener, Aldana; Sabach, Efrat; Soker, Noam

    2018-05-01

    We calculate the outward energy transport time by convection and photon diffusion in an inflated common envelope and find this time to be shorter than the envelope expansion time. We conclude therefore that most of the hydrogen recombination energy ends in radiation rather than in kinetic energy of the outflowing envelope. We use the stellar evolution code MESA and inject energy inside the envelope of an asymptotic giant branch star to mimic energy deposition by a spiraling-in stellar companion. During 1.7 years the envelope expands by a factor of more than 2. Along the entire evolution the convection can carry the energy very efficiently outwards, to the radius where radiative transfer becomes more efficient. The total energy transport time stays within several months, shorter than the dynamical time of the envelope. Had we included rapid mass loss, as is expected in the common envelope evolution, the energy transport time would have been even shorter. It seems that calculations that assume that most of the recombination energy ends in the outflowing gas might be inaccurate.

  7. Critical point analysis of phase envelope diagram

    Energy Technology Data Exchange (ETDEWEB)

    Soetikno, Darmadi; Siagian, Ucok W. R. [Department of Petroleum Engineering, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung 40132 (Indonesia); Kusdiantara, Rudy, E-mail: rkusdiantara@s.itb.ac.id; Puspita, Dila, E-mail: rkusdiantara@s.itb.ac.id; Sidarto, Kuntjoro A., E-mail: rkusdiantara@s.itb.ac.id; Soewono, Edy; Gunawan, Agus Y. [Department of Mathematics, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung 40132 (Indonesia)

    2014-03-24

    Phase diagram or phase envelope is a relation between temperature and pressure that shows the condition of equilibria between the different phases of chemical compounds, mixture of compounds, and solutions. Phase diagram is an important issue in chemical thermodynamics and hydrocarbon reservoir. It is very useful for process simulation, hydrocarbon reactor design, and petroleum engineering studies. It is constructed from the bubble line, dew line, and critical point. Bubble line and dew line are composed of bubble points and dew points, respectively. Bubble point is the first point at which the gas is formed when a liquid is heated. Meanwhile, dew point is the first point where the liquid is formed when the gas is cooled. Critical point is the point where all of the properties of gases and liquids are equal, such as temperature, pressure, amount of substance, and others. Critical point is very useful in fuel processing and dissolution of certain chemicals. Here in this paper, we will show the critical point analytically. Then, it will be compared with numerical calculations of Peng-Robinson equation by using Newton-Raphson method. As case studies, several hydrocarbon mixtures are simulated using by Matlab.

  8. Critical point analysis of phase envelope diagram

    International Nuclear Information System (INIS)

    Soetikno, Darmadi; Siagian, Ucok W. R.; Kusdiantara, Rudy; Puspita, Dila; Sidarto, Kuntjoro A.; Soewono, Edy; Gunawan, Agus Y.

    2014-01-01

    Phase diagram or phase envelope is a relation between temperature and pressure that shows the condition of equilibria between the different phases of chemical compounds, mixture of compounds, and solutions. Phase diagram is an important issue in chemical thermodynamics and hydrocarbon reservoir. It is very useful for process simulation, hydrocarbon reactor design, and petroleum engineering studies. It is constructed from the bubble line, dew line, and critical point. Bubble line and dew line are composed of bubble points and dew points, respectively. Bubble point is the first point at which the gas is formed when a liquid is heated. Meanwhile, dew point is the first point where the liquid is formed when the gas is cooled. Critical point is the point where all of the properties of gases and liquids are equal, such as temperature, pressure, amount of substance, and others. Critical point is very useful in fuel processing and dissolution of certain chemicals. Here in this paper, we will show the critical point analytically. Then, it will be compared with numerical calculations of Peng-Robinson equation by using Newton-Raphson method. As case studies, several hydrocarbon mixtures are simulated using by Matlab

  9. The eikonal equation, envelopes and contact transformations

    International Nuclear Information System (INIS)

    Frittelli, Simonetta; Kamran, Niky; Newman, Ezra T

    2003-01-01

    We begin with an arbitrary but given conformal Lorentzian metric on an open neighbourhood, U, of a four-dimensional manifold (spacetime) and study families of solutions of the eikonal equation. In particular, the families that are of interest to us are the complete solutions. Their level surfaces form a two-parameter (points of S 2 ) family of foliations of U. We show that, from such a complete solution, it is possible to derive a pair of second-order PDEs defined solely on the parameter space S 2 , i.e., they have no reference to the spacetime points. We then show that if one uses the classical envelope method for the construction of new complete solutions from any given complete solution, then the new pair of PDEs (found from the new complete solution) is related to the old pair by contact transformations in the second jet bundle over S 2 . Further, we demonstrate that the pair of second-order PDEs obtained in this manner from any complete solution lies in a subclass of all pairs of second-order PDEs defined by the vanishing of a certain function obtained from the pair and is referred to as the generalized-Wuenschmann invariant. For completeness we briefly discuss the analogous issues associated with the eikonal equation in three dimensions. Finally we point out that conformally invariant geometric structures from the Lorentzian manifold have natural counterparts in the second jet bundle over S 2 on which the pair of PDEs lives

  10. Ecosystem functioning is enveloped by hydrometeorological variability.

    Science.gov (United States)

    Pappas, Christoforos; Mahecha, Miguel D; Frank, David C; Babst, Flurin; Koutsoyiannis, Demetris

    2017-09-01

    Terrestrial ecosystem processes, and the associated vegetation carbon dynamics, respond differently to hydrometeorological variability across timescales, and so does our scientific understanding of the underlying mechanisms. Long-term variability of the terrestrial carbon cycle is not yet well constrained and the resulting climate-biosphere feedbacks are highly uncertain. Here we present a comprehensive overview of hydrometeorological and ecosystem variability from hourly to decadal timescales integrating multiple in situ and remote-sensing datasets characterizing extra-tropical forest sites. We find that ecosystem variability at all sites is confined within a hydrometeorological envelope across sites and timescales. Furthermore, ecosystem variability demonstrates long-term persistence, highlighting ecological memory and slow ecosystem recovery rates after disturbances. However, simulation results with state-of-the-art process-based models do not reflect this long-term persistent behaviour in ecosystem functioning. Accordingly, we develop a cross-time-scale stochastic framework that captures hydrometeorological and ecosystem variability. Our analysis offers a perspective for terrestrial ecosystem modelling and paves the way for new model-data integration opportunities in Earth system sciences.

  11. Fullerenes and fulleranes in circumstellar envelopes

    International Nuclear Information System (INIS)

    Zhang, Yong; Kwok, Sun; Sadjadi, SeyedAbdolreza

    2016-01-01

    Three decades of search have recently led to convincing discoveries of cosmic fullerenes. The presence of C_6_0 and C"+ _6_0 in both circumstellar and interstellar environments suggests that these molecules and their derivatives can be efficiently formed in circumstellar envelopes and survive in harsh conditions. Detailed analysis of the infrared bands from fullerenes and their connections with the local properties can provide valuable information on the physical conditions and chemical processes that occurred in the late stages of stellar evolution. The identification of C"+ _6_0 as the carrier of four diffuse interstellar bands (DIBs) suggests that fullerene- related compounds are abundant in interstellar space and are essential for resolving the DIB mystery. Experiments have revealed a high hydrogenation rate when C_6_0 is exposed to atomic hydrogen, motivating the attempt to search for cosmic fulleranes. In this paper, we present a short review of current knowledge of cosmic fullerenes and fulleranes and briefly discuss the implications on circumstellar chemistry. (paper)

  12. Importance of riparian remnants for frog species diversity in a highly fragmented rainforest.

    Science.gov (United States)

    Rodríguez-Mendoza, Clara; Pineda, Eduardo

    2010-12-23

    Tropical forests undergo continuous transformation to other land uses, resulting in landscapes typified by forest fragments surrounded by anthropogenic habitats. Small forest fragments, specifically strip-shaped remnants flanking streams (referred to as riparian remnants), can be particularly important for the maintenance and conservation of biodiversity within highly fragmented forests. We compared frog species diversity between riparian remnants, other forest fragments and cattle pastures in a tropical landscape in Los Tuxtlas, Mexico. We found similar species richness in the three habitats studied and a similar assemblage structure between riparian remnants and forest fragments, although species composition differed by 50 per cent. Frog abundance was halved in riparian remnants compared with forest fragments, but was twice that found in pastures. Our results suggest that riparian remnants play an important role in maintaining a portion of frog species diversity in a highly fragmented forest, particularly during environmentally stressful (hot and dry) periods. In this regard, however, the role of riparian remnants is complementary, rather than substitutive, with respect to the function of other forest fragments within the fragmented forest.

  13. Remnant Cholesterol Elicits Arterial Wall Inflammation and a Multilevel Cellular Immune Response in Humans.

    Science.gov (United States)

    Bernelot Moens, Sophie J; Verweij, Simone L; Schnitzler, Johan G; Stiekema, Lotte C A; Bos, Merijn; Langsted, Anne; Kuijk, Carlijn; Bekkering, Siroon; Voermans, Carlijn; Verberne, Hein J; Nordestgaard, Børge G; Stroes, Erik S G; Kroon, Jeffrey

    2017-05-01

    Mendelian randomization studies revealed a causal role for remnant cholesterol in cardiovascular disease. Remnant particles accumulate in the arterial wall, potentially propagating local and systemic inflammation. We evaluated the impact of remnant cholesterol on arterial wall inflammation, circulating monocytes, and bone marrow in patients with familial dysbetalipoproteinemia (FD). Arterial wall inflammation and bone marrow activity were measured using 18 F-FDG PET/CT. Monocyte phenotype was assessed with flow cytometry. The correlation between remnant levels and hematopoietic activity was validated in the CGPS (Copenhagen General Population Study). We found a 1.2-fold increase of 18 F-FDG uptake in the arterial wall in patients with FD (n=17, age 60±8 years, remnant cholesterol: 3.26 [2.07-5.71]) compared with controls (n=17, age 61±8 years, remnant cholesterol 0.29 [0.27-0.40]; P wall and cellular inflammation. These findings imply an important inflammatory component to the atherogenicity of remnant cholesterol, contributing to the increased cardiovascular disease risk in patients with FD. © 2017 American Heart Association, Inc.

  14. Cholesterol remnants and triglycerides are associated with decreased myocardial function in patients with type 2 diabetes

    DEFF Research Database (Denmark)

    Jørgensen, Peter Godsk; Jensen, Magnus Thorsten; Biering-Sørensen, Tor

    2016-01-01

    BACKGROUND: Recently, genetic studies have suggested a causal relationship between cholesterol remnants and ischemic heart disease. We aimed to determine whether cholesterol remnants and its marker, triglyceride levels, are associated with cardiac function as determined by sensitive echocardiogra......BACKGROUND: Recently, genetic studies have suggested a causal relationship between cholesterol remnants and ischemic heart disease. We aimed to determine whether cholesterol remnants and its marker, triglyceride levels, are associated with cardiac function as determined by sensitive...... secondary care centers. RESULTS: In multivariable analyses, triglycerides and cholesterol remnants were not associated with left ventricular ejection fraction, but with subtle measures of systolic function, including global longitudinal strain by speckle tracking and longitudinal displacement by tissue...... Doppler echocardiography: global longitudinal strain [0.33 % (0.14), p = 0.02 per doubling in cholesterol remnants and 0.28 % (0.13), p = 0.03 per doubling in triglyceride levels] and with longitudinal displacement [-0.25 mm (0.10), p = 0.01 per doubling in cholesterol remnants and -0.25 mm (0.09), p = 0...

  15. Use of response envelopes for seismic margin assessment of reinforced concrete walls and slabs

    Energy Technology Data Exchange (ETDEWEB)

    Ile, Nicolas; Frau, Alberto, E-mail: alberto.frau@cea.fr

    2017-04-01

    Highlights: • Proposal of a method for application of the elliptical envelope to RC shell elements. • Proposal of new algorithms for the seismic margin evaluation for RC shell elements. • Verification of a RC wall 3D structure, using the proposed assessment approach. - Abstract: Seismic safety evaluations of existing nuclear facilities are usually based on the assumption of structural linearity. For the design basis earthquake (DBE), it is reasonable to apply a conventional evaluation of the seismic safety of building structures and carry out a linear elastic analysis to assess the load effects on structural elements. Estimating the seismic capacity of a structural element requires an estimation of the critical combination of responses acting in this structural element and compare this combination with the capacity of the element. By exploiting the response-spectrum-based procedure for predicting the response envelopes in linear structures formulated by Menun and Der Kiureghian (2000a), algorithms are developed for the seismic margin assessment of reinforced concrete shell finite elements. These algorithms facilitate the comparison of the response-spectrum-based envelopes to prescribed capacity surfaces for the purpose of assessing the safety margin of this kind of structures. The practical application of elliptical response envelopes in case of shell finite elements is based on the use of layer models such as those developed by Marti (1990), which transfer the generalized stress field to three layers under the assumption that the two outer layers carry membrane forces and the internal layer carries only the out-of-plane shears. The utility of the assessment approach is discussed with reference to a case study of a 3D structure made of reinforced concrete walls.

  16. Use of response envelopes for seismic margin assessment of reinforced concrete walls and slabs

    International Nuclear Information System (INIS)

    Ile, Nicolas; Frau, Alberto

    2017-01-01

    Highlights: • Proposal of a method for application of the elliptical envelope to RC shell elements. • Proposal of new algorithms for the seismic margin evaluation for RC shell elements. • Verification of a RC wall 3D structure, using the proposed assessment approach. - Abstract: Seismic safety evaluations of existing nuclear facilities are usually based on the assumption of structural linearity. For the design basis earthquake (DBE), it is reasonable to apply a conventional evaluation of the seismic safety of building structures and carry out a linear elastic analysis to assess the load effects on structural elements. Estimating the seismic capacity of a structural element requires an estimation of the critical combination of responses acting in this structural element and compare this combination with the capacity of the element. By exploiting the response-spectrum-based procedure for predicting the response envelopes in linear structures formulated by Menun and Der Kiureghian (2000a), algorithms are developed for the seismic margin assessment of reinforced concrete shell finite elements. These algorithms facilitate the comparison of the response-spectrum-based envelopes to prescribed capacity surfaces for the purpose of assessing the safety margin of this kind of structures. The practical application of elliptical response envelopes in case of shell finite elements is based on the use of layer models such as those developed by Marti (1990), which transfer the generalized stress field to three layers under the assumption that the two outer layers carry membrane forces and the internal layer carries only the out-of-plane shears. The utility of the assessment approach is discussed with reference to a case study of a 3D structure made of reinforced concrete walls.

  17. DATA ENVELOPMENT ANALYSIS OF BANKING SECTOR IN BANGLADESH

    Directory of Open Access Journals (Sweden)

    Md. Rashedul Hoque

    2012-05-01

    Full Text Available Banking sector of Bangladesh is flourishing and contributing to its economy. In this aspect measuring efficiency is important. Data Envelopment Analysis technique is used for this purpose. The data are collected from the annual reports of twenty four different banks in Bangladesh. Data Envelopment Analysis is mainly of two types - constant returns to scale and variable returns to scale. Since this study attempts to maximize output, so the output oriented Data Envelopment Analysis is used. The most efficient bank is one that obtains the highest efficiency score.

  18. Pre-paid envelopes commemorating the 2013 Open Days

    CERN Multimedia

    2013-01-01

    The post office on CERN's Prévessin site is still selling pre-paid envelopes commemorating the 2013 Open Days. Hurry while stocks last!   The special envelopes, which are valid in France for non-priority letters weighing up to 20 grams, are ideal for your Christmas and New Year correspondence. A set of ten envelopes, each featuring a different image, costs € 8.70 or 10 CHF. The post office is located in Building 866 on the Prévessin site and is open Mondays to Thursdays from 9.30 a.m. to 12.30 p.m.

  19. Influence of the Roof Movement Control Method on the Stability of Remnant

    Science.gov (United States)

    Adach-Pawelus, Karolina

    2017-12-01

    In the underground mines, there are geological and mining situations that necessitate leaving behind remnants in the mining field. Remnants, in the form of small, irregular parcels, are usually separated in the case of: significant problems with maintaining roof stability, high rockburst hazard, the occurrence of complex geological conditions and for random reasons (ore remnants), as well as for economic reasons (undisturbed rock remnants). Remnants left in the mining field become sites of high stress values concentration and may affect the rock in their vicinity. The values of stress inside the remnant and its vicinity, as well as the stability of the remnant, largely depend on the roof movement control method used in the mining field. The article presents the results of the numerical analysis of the influence of roof movement control method on remnant stability and the geomechanical situation in the mining field. The numerical analysis was conducted for the geological and mining conditions characteristic of Polish underground copper mines owned by KGHM Polska Miedz S.A. Numerical simulations were performed in a plane strain state by means of Phase 2 v. 8.0 software, based on the finite element method. The behaviour of remnant and rock mass in its vicinity was simulated in the subsequent steps of the room and pillar mining system for three types of roof movement control method: roof deflection, dry backfill and hydraulic backfill. The parameters of the rock mass accepted for numerical modelling were calculated by means of RocLab software on the basis of the Hoek-Brown classification. The Mohr-Coulomb strength criterion was applied.

  20. CHARACTERISTICS OF EPIRETINAL MEMBRANE REMNANT EDGE BY OPTICAL COHERENCE TOMOGRAPHY AFTER PARS PLANA VITRECTOMY.

    Science.gov (United States)

    Gaber, Raouf; You, Qi Sheng; Muftuoglu, Ilkay Kilic; Alam, Mostafa; Tsai, Frank F; Mendoza, Nadia; Freeman, William R

    2017-11-01

    To evaluate the incidence, characteristics, and the progression of epiretinal membrane (ERM) remnant edge seen by optical coherence tomography after ERM peeling. A retrospective chart review was conducted for 86 eyes of 85 consecutive patients who were diagnosed with ERM and underwent pars plana vitrectomy for epiretinal membrane peeling between 2013 and 2014. Data collected and analyzed included age, gender, preoperative and postoperative visual acuity, use of indocyanine green dye to stain internal limiting membrane, tamponade used after vitrectomy, ERM edge boundaries, presence of cystoid macular edema, and central foveal thickness. An ERM remnant edge was detected in 33/86 study eyes (38.4%) at the first postoperative optical coherence tomography scan. Compared with those without an ERM remnant, patients with an ERM remnant after surgery were significantly older at baseline and had a higher incidence of ERM recurrence at their last visit. They were not significantly different in terms of gender, preoperative and postoperative visual acuity, reduction of central foveal thickness from baseline, proportion of eyes with preoperative ERM elevation on optical coherence tomography, presence of macular edema before surgery, intraoperative use of indocyanine green staining for ILM peeling, or tamponade used. Based on the edge morphology, we classified the ERM remnant into three types: Type 1 was flat and blended with the retina (14/33 eyes, 42.4%), Type 2 was flat but stepped (17/33 eyes, 51.5%), and Type 3 was elevated (2/33 eyes, 6.0%). A significantly higher risk of ERM recurrence was seen in Type 2 and Type 3 ERM remnants (75% and 100%, respectively) than Type 1 ERM remnants (10%). An ERM remnant edge was detected by optical coherence tomography after ERM peeling in 38.4% of eyes. The presence of a postoperative ERM edge was associated with a higher risk of ERM recurrence, particularly in Type 2 and Type 3 ERM remnants.

  1. DEM L241, A SUPERNOVA REMNANT CONTAINING A HIGH-MASS X-RAY BINARY

    International Nuclear Information System (INIS)

    Seward, F. D.; Charles, P. A.; Foster, D. L.; Dickel, J. R.; Romero, P. S.; Edwards, Z. I.; Perry, M.; Williams, R. M.

    2012-01-01

    A Chandra observation of the Large Magellanic Cloud supernova remnant DEM L241 reveals an interior unresolved source which is probably an accretion-powered binary. The optical counterpart is an O5III(f) star making this a high-mass X-ray binary with an orbital period likely to be of the order of tens of days. Emission from the remnant interior is thermal and spectral information is used to derive density and mass of the hot material. Elongation of the remnant is unusual and possible causes of this are discussed. The precursor star probably had mass >25 M ☉

  2. DEM L241, A SUPERNOVA REMNANT CONTAINING A HIGH-MASS X-RAY BINARY

    Energy Technology Data Exchange (ETDEWEB)

    Seward, F. D. [Smithsonian Astrophysical Observatory, 60 Garden Street, Cambridge, MA 02138 (United States); Charles, P. A. [School of Physics and Astronomy, University of Southampton, Highfield, Southampton SO17 1BJ (United Kingdom); Foster, D. L. [South African Astronomical Observatory, P.O. Box 9, Observatory 7935, Cape Town (South Africa); Dickel, J. R.; Romero, P. S. [Department of Physics and Astronomy, University of New Mexico, 1919 Lomas Boulevard NE, Albuquerque, NM 87131 (United States); Edwards, Z. I.; Perry, M.; Williams, R. M. [Department of Earth and Space Sciences, Columbus State University, Coca Cola Space Science Center, 701 Front Avenue, Columbus, GA 31901 (United States)

    2012-11-10

    A Chandra observation of the Large Magellanic Cloud supernova remnant DEM L241 reveals an interior unresolved source which is probably an accretion-powered binary. The optical counterpart is an O5III(f) star making this a high-mass X-ray binary with an orbital period likely to be of the order of tens of days. Emission from the remnant interior is thermal and spectral information is used to derive density and mass of the hot material. Elongation of the remnant is unusual and possible causes of this are discussed. The precursor star probably had mass >25 M {sub Sun}.

  3. Mucocele of the cystic duct remnant after orthotopic liver transplant: a problem revisited.

    Science.gov (United States)

    Chatterjee, Suvadip; Das, Debasish; Hudson, Mark; Bassendine, Margaret Fiona; Scott, John; Oppong, Kofi Ernest; Sen, Gourab; French, Jeremy J

    2011-06-01

    Mucocele of the cystic duct remnant is an uncommon hepatobiliary complication of a liver transplant. Current practice usually involves either excising the cystic duct, or incorporating the distal end of the transected cystic duct into the suture line of the biliary anastomosis to ensure drainage. We report a patient who developed cystic duct remnant mucocele after the latter approach was adopted. We believe that this is likely related to delayed anastomotic stricturing, which prevented draining from the remnant cystic duct. We also discuss the incidence, pathology, investigations, and treatment of this condition.

  4. Numerical code for fitting radial emission profile of a shell supernova remnant: Application

    Directory of Open Access Journals (Sweden)

    Opsenica Slobodan

    2011-01-01

    Full Text Available We present IDL (Interactive Data Language codes for fitting a theoretical emission profile of a shell supernova remnant (SNR to the mean profile of an SNR obtained from radio observations. Two considered theoretical models are: 1 a shell with constant emissivity and 2 a synchrotron shell with radially aligned magnetic field. The codes were applied to several observed supernova remnants. Good results are obtained in five considered cases, which justify the use of our code for remnants that are bright (so that observational errors are not large and spherically symmetric enough.

  5. Supernova remnant S147 and its associated neutron star(s)

    OpenAIRE

    Gvaramadze, V. V.

    2005-01-01

    The supernova remnant S147 harbors the pulsar PSR J0538+2817 whose characteristic age is more than an order of magnitude greater than the kinematic age of the system (inferred from the angular offset of the pulsar from the geometric center of the supernova remnant and the pulsar proper motion). To reconcile this discrepancy we propose that PSR J0538+2817 could be the stellar remnant of the first supernova explosion in a massive binary system and therefore could be as old as its characteristic...

  6. Pervasive Defaunation of Forest Remnants in a Tropical Biodiversity Hotspot

    Science.gov (United States)

    Canale, Gustavo R.; Peres, Carlos A.; Guidorizzi, Carlos E.; Gatto, Cassiano A. Ferreira; Kierulff, Maria Cecília M.

    2012-01-01

    Tropical deforestation and forest fragmentation are among the most important biodiversity conservation issues worldwide, yet local extinctions of millions of animal and plant populations stranded in unprotected forest remnants remain poorly explained. Here, we report unprecedented rates of local extinctions of medium to large-bodied mammals in one of the world's most important tropical biodiversity hotspots. We scrutinized 8,846 person-years of local knowledge to derive patch occupancy data for 18 mammal species within 196 forest patches across a 252,669-km2 study region of the Brazilian Atlantic Forest. We uncovered a staggering rate of local extinctions in the mammal fauna, with only 767 from a possible 3,528 populations still persisting. On average, forest patches retained 3.9 out of 18 potential species occupancies, and geographic ranges had contracted to 0–14.4% of their former distributions, including five large-bodied species that had been extirpated at a regional scale. Forest fragments were highly accessible to hunters and exposed to edge effects and fires, thereby severely diminishing the predictive power of species-area relationships, with the power model explaining only ∼9% of the variation in species richness per patch. Hence, conventional species-area curves provided over-optimistic estimates of species persistence in that most forest fragments had lost species at a much faster rate than predicted by habitat loss alone. PMID:22905103

  7. Pervasive defaunation of forest remnants in a tropical biodiversity hotspot.

    Directory of Open Access Journals (Sweden)

    Gustavo R Canale

    Full Text Available Tropical deforestation and forest fragmentation are among the most important biodiversity conservation issues worldwide, yet local extinctions of millions of animal and plant populations stranded in unprotected forest remnants remain poorly explained. Here, we report unprecedented rates of local extinctions of medium to large-bodied mammals in one of the world's most important tropical biodiversity hotspots. We scrutinized 8,846 person-years of local knowledge to derive patch occupancy data for 18 mammal species within 196 forest patches across a 252,669-km(2 study region of the Brazilian Atlantic Forest. We uncovered a staggering rate of local extinctions in the mammal fauna, with only 767 from a possible 3,528 populations still persisting. On average, forest patches retained 3.9 out of 18 potential species occupancies, and geographic ranges had contracted to 0-14.4% of their former distributions, including five large-bodied species that had been extirpated at a regional scale. Forest fragments were highly accessible to hunters and exposed to edge effects and fires, thereby severely diminishing the predictive power of species-area relationships, with the power model explaining only ~9% of the variation in species richness per patch. Hence, conventional species-area curves provided over-optimistic estimates of species persistence in that most forest fragments had lost species at a much faster rate than predicted by habitat loss alone.

  8. Cold H I clouds near the supernova remnant W44

    International Nuclear Information System (INIS)

    Sato, F.

    1986-01-01

    The cold H I clouds near the supernova remnant W44 are investigated by the use of the Maryland-Green Bank Survey (Westerhout 1973). Several clouds with a mean diameter of about 20 pc are distributed in the region. They do not seem to make a shell around W44, contrary to the suggestion by Knapp and Kerr (1974) based on the low-resolution data at coarse grids. Some of them form a chain, about 100 pc in length, extending approximately along the galactic equator. It resembles the cold H I cloud near W3 and W4. The major constituent of the clouds is probably the hydrogen molecule, and the total mass of the entire complex amounts to 25,000 81,000 solar masses. The estimated Jeans mass indicates that they will contract to dense molecular clouds. Therefore, it may safely be concluded that the cold H1 cloud complex near W44 is a giant molecular cloud at an early evolutionary stage. 14 references

  9. Comparing Neutron Star Kicks to Supernova Remnant Asymmetries

    Energy Technology Data Exchange (ETDEWEB)

    Holland-Ashford, Tyler; Lopez, Laura A. [The Ohio State University Department of Astronomy, 140 W 18th Avenue, Columbus, OH 43201 (United States); Auchettl, Katie [The Ohio State University Center for Cosmology and Astro-particle Physics, 191 West Woodruff Avenue, Columbus, OH 43210 (United States); Temim, Tea [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Ramirez-Ruiz, Enrico, E-mail: holland-ashford.1@osu.edu [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States)

    2017-07-20

    Supernova explosions are inherently asymmetric and can accelerate new-born neutron stars (NSs) to hundreds of km s{sup −1}. Two prevailing theories to explain NS kicks are ejecta asymmetries (e.g., conservation of momentum between NS and ejecta) and anisotropic neutrino emission. Observations of supernova remnants (SNRs) can give us insights into the mechanism that generates these NS kicks. In this paper, we investigate the relationship between NS kick velocities and the X-ray morphologies of 18 SNRs observed with the Chandra X-ray Observatory and the Röntgen Satellite ( ROSAT ). We measure SNR asymmetries using the power-ratio method (a multipole expansion technique), focusing on the dipole, quadrupole, and octupole power ratios. Our results show no correlation between the magnitude of the power ratios and NS kick velocities, but we find that for Cas A and G292.0+1.8, whose emission traces the ejecta distribution, their NSs are preferentially moving opposite to the bulk of the X-ray emission. In addition, we find a similar result for PKS 1209–51, CTB 109, and Puppis A; however, their emission is dominated by circumstellar/interstellar material, so their asymmetries may not reflect their ejecta distributions. Our results are consistent with the theory that NS kicks are a consequence of ejecta asymmetries as opposed to anisotropic neutrino emission. In the future, additional observations to measure NS proper motions within ejecta-dominated SNRs are necessary to robustly constrain the NS kick mechanism.

  10. Search for surviving companions in type Ia supernova remnants

    International Nuclear Information System (INIS)

    Pan, Kuo-Chuan; Ricker, Paul M.; Taam, Ronald E.

    2014-01-01

    The nature of the progenitor systems of type Ia supernovae (SNe Ia) is still unclear. One way to distinguish between the single-degenerate scenario and double-degenerate scenario for their progenitors is to search for the surviving companions (SCs). Using a technique that couples the results from multi-dimensional hydrodynamics simulations with calculations of the structure and evolution of main-sequence- (MS-) and helium-rich SCs, the color and magnitude of MS- and helium-rich SCs are predicted as functions of time. The SC candidates in Galactic type Ia supernova remnants (Ia SNR) and nearby extragalactic Ia SNRs are discussed. We find that the maximum detectable distance of MS SCs (helium-rich SCs) is 0.6-4 Mpc (0.4-16 Mpc), if the apparent magnitude limit is 27 in the absence of extinction, suggesting that the Large and Small Magellanic Clouds and the Andromeda Galaxy are excellent environments in which to search for SCs. However, only five Ia SNRs have been searched for SCs, showing little support for the standard channels in the singe-degenerate scenario. To better understand the progenitors of SNe Ia, we encourage the search for SCs in other nearby Ia SNRs.

  11. Fermi-LAT Observation of Supernova Remnant S147

    Energy Technology Data Exchange (ETDEWEB)

    Katsuta, J.; Uchiyama, Y.; Tanaka, T.; /SLAC /KIPAC, Menlo Park; Tajima, H.; /SLAC /KIPAC, Menlo Park /Nagoya U., Solar-Terrestrial Environ. Lab.; Bechtol, K.; Funk, S.; Lande, J.; /SLAC /KIPAC, Menlo Park; Ballet, J.; /AIM, Saclay; Hanabata, Y.; /Hiroshima U.; Lemoine-Goumard, M.; /CENBG, Gradignan; Takahashi, T.; /JAXA, Sagamihara

    2012-08-17

    We present an analysis of gamma-ray data obtained with the Large Area Telescope (LAT) onboard the Fermi Gamma-ray Space Telescope in the region around SNR S147 (G180.0-1.7). A spatially extended gamma-ray source detected in an energy range of 0.2-10 GeV is found to coincide with SNR S147. We confirm its spatial extension at >5{sigma} confidence level. The gamma-ray flux is (3.8 {+-} 0.6) x 10{sup -8} photons cm{sup -2} s{sup -1}, corresponding to a luminosity of 1.3 x 10{sup 34} (d/1.3 kpc){sup 2} erg s{sup -1} in this energy range. The gamma-ray emission exhibits a possible spatial correlation with prominent H{alpha} filaments of S147. There is no indication that the gamma-ray emission comes from the associated pulsar PSR J0538+2817. The gamma-ray spectrum integrated over the remnant is likely dominated by the decay of neutral {pi} mesons produced through the proton-proton collisions in the filaments. Reacceleration of pre-existing CRs and subsequent adiabatic compression in the filaments is sufficient to provide the required energy density of high-energy protons.

  12. Evolution of Supernova Remnants Near the Galactic Center

    Energy Technology Data Exchange (ETDEWEB)

    Yalinewich, A.; Piran, T.; Sari, R. [Racah Institute of Physics, the Hebrew University, 91904, Jerusalem (Israel)

    2017-03-20

    Supernovae near the Galactic center (GC) evolve differently from regular Galactic supernovae. This is mainly due to the environment into which the supernova remnants (SNRs) propagate. SNRs near the GC propagate into a wind swept environment with a velocity directed away from the GC, and a graded density profile. This causes these SNRs to be non-spherical, and to evolve faster than their Galactic counterparts. We develop an analytic theory for the evolution of explosions within a stellar wind, and verify it using a hydrodynamic code. We show that such explosions can evolve in one of three possible morphologies. Using these results we discuss the association between the two SNRs (SGR East and SGR A’s bipolar radio/X-ray lobes) and the two neutron stars (the Cannonball and SGR J1745-2900) near the GC. We show that, given the morphologies of the SNR and positions of the neutron stars, the only possible association is between SGR A’s bipolar radio/X-ray lobes and SGR J1745-2900. If a compact object was created in the explosion of SGR East, it remains undetected, and the SNR of the supernova that created the Cannonball has already disappeared.

  13. Superdiffusion of relativistic electrons at supernova remnant shocks

    Science.gov (United States)

    Perri, Silvia

    2018-01-01

    Anomalous transport has been observed in various systems as nonlinear systems, numerical simulations of plasma turbulence, in laboratory plasmas, and recently in the propagation of energetic particles in the interplanetary space. Thanks to in situ observations it has been possible to deduce transport properties directly from spacecraft data. This technique has further found applicability to remote observations of relativistic electrons accelerated at supernova remnants (SNRs) shocks, pointing out that far upstream of the blast waves, the x-ray synchrotron emission, as captured by the Chandra spacecraft, is consistent with models of superdiffusive transport (i.e., transport faster than normal diffusive). Here we present and summarize evidences of superdiffusion both in the interplanetary space and upstream of SNRs shock fronts, in particular by analyzing, for the first time in the framework of superdiffusion, the transport properties of electrons accelerated at the young G1.9+0.3 SNR. We also briefly describe how this new model can be used to interpret radio emissions from electrons accelerated at shocks forming during galaxy cluster mergers.

  14. EXPECTATION ON OBSERVATION OF SUPERNOVA REMNANTS WITH THE LHAASO PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Ye; Huang, Xingtao [School of Physics and Key Laboratory of Particle Physics and Particle Irradiation (MOE), Shandong University, Jinan 250100 (China); Cao, Zhen; Chen, Songzhan; He, Huihai; Ma, Xinhua [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Chen, Yang; Zhang, Xiao [Department of Astronomy, Nanjing University, Nanjing 210093 (China); Cui, Shuwang [The College of Physics Science and Information Engineering, Hebei Normal University, Shijiazhuang, 050016 (China); Yuan, Qiang, E-mail: huangxt@sdu.edu.cn, E-mail: maxh@ihep.ac.cn [Department of Astronomy, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (United States); Collaboration: On behalf of the LHAASO Collaboration

    2016-07-20

    Supernova remnants (SNRs) are believed to be the most important acceleration sites for cosmic rays (CRs) below ∼10{sup 15} eV in the Galaxy. High-energy photons, either directly from the shocks of the SNRs or indirectly from the interaction between SNRs and the nearby clouds, are crucial probes for the CR acceleration. Big progresses on observations of SNRs have been achieved by space- and ground-based γ -ray facilities. However, whether γ -rays come from accelerated hadrons or not, as well as their connection with the CRs observed at Earth, remains in debate. Large High Altitude Air Shower Observatory (LHAASO), a next-generation experiment, is designed to survey the northern part of the very high energy γ -ray sky from ∼0.3 TeV to PeV with the sensitivity of ≲1% of the Crab Nebula flux. In this paper, we indicate that LHAASO will be dedicated to enlarging the γ -ray SNR samples and improving the spectral and morphological measurements. These measurements, especially at energies above 30 TeV, will be important for us to finally understand the CR acceleration in SNRs.

  15. The Population of Supernova Remnants in M51

    Science.gov (United States)

    Long, Knox S.; Blair, William P.; Kuntz, K. D.; Winkler, P. Frank

    2017-08-01

    The nearby, actively star-forming, nearly face-on spiral galaxy, M51 (NGC 5194/5), has been the site of four supernovae since 1941. As a result it should have a rich population of young supernova remnants (SNRs). Here we describe a search for optical SNRs in M51 among the 298 X-ray sources discovered inside the D25 contour in deep Chandra observations. The search uses interference filter images obtained with the WFC3 on Hubble Space Telescope and more recent images from GMOS on Gemini North. Of 80 emission nebulae identified in the HST images as SNR candidates based on elevated [SII]: Ha ratios compared to HII regions, 40 have X-ray counterparts. The diameters of the SNRs and SNR candidates detected with HST are systematically smaller than seen in SNR populations of other galaxies at comparable distances. However, this is most likely an instrumental effect, which our ongoing analysis of the new GMOS images will correct. At that point, we will be able to make of fair multi-wavelength comparison of the SNR population in M51 with other nearby, actively star-forming spiral galaxies, such as M83 and NGC6946.

  16. Acceleration of cosmic rays in supernova-remnants

    Science.gov (United States)

    Dorfi, E. A.; Drury, L. O.

    1985-01-01

    It is commonly accepted that supernova-explosions are the dominant source of cosmic rays up to an energy of 10 to the 14th power eV/nucleon. Moreover, these high energy particles provide a major contribution to the energy density of the interstellar medium (ISM) and should therefore be included in calculations of interstellar dynamic phenomena. For the following the first order Fermi mechanism in shock waves are considered to be the main acceleration mechanism. The influence of this process is twofold; first, if the process is efficient (and in fact this is the cas) it will modify the dynamics and evolution of a supernova-remnant (SNR), and secondly, the existence of a significant high energy component changes the overall picture of the ISM. The complexity of the underlying physics prevented detailed investigations of the full non-linear selfconsistent problem. For example, in the context of the energy balance of the ISM it has not been investigated how much energy of a SN-explosion can be transfered to cosmic rays in a time-dependent selfconsistent model. Nevertheless, a lot of progress was made on many aspects of the acceleration mechanism.

  17. Acceleration of cosmic rays in supernova-remnants

    International Nuclear Information System (INIS)

    Dorfi, E.A.; Drury, L.O.

    1985-01-01

    It is commonly accepted that supernova-explosions are the dominant source of cosmic rays up to an energy of 10 to the 14th power eV/nucleon. Moreover, these high energy particles provide a major contribution to the energy density of the interstellar medium (ISM) and should therefore be included in calcuations of interstellar dynamic phenomena. For the following the first order Fermi mechanism in shock waves are considered to be the main acceleration mechanism. The influence of this process is twofold; first, if the process is efficient (and in fact this is the case) it will modify the dynamics and evolution of a supernova-remnant (SNR), and secondly, the existence of a significant high energy component changes the overall picture of the ISM. The complexity of the underlying physics prevented detailed investigations of the full non-linear selfconsistent problem. For example, in the context of the energy balance of the ISM it has not been investigated how much energy of a SN-explosion can be transfered to cosmic rays in a time-dependent selfconsistent model. Nevertheless, a lot of progress was made on many aspects of the acceleration mechnism

  18. The high energy X-ray spectra of supernova remnants

    Science.gov (United States)

    Pravdo, S. H.; Nugent, J. J.

    The results of fitting an ionization-nonequilibrium (INE) model to the high-energy (above 5-keV) X-ray spectra of the young supernova remnants Cas A and Tycho are presented. As an additional constraint, the models must simultaneously fit lower-energy, higher-resolution data. For Cas A, a single INE component cannot adequately reproduce the features for the entire X-ray spectrum because the ionization structure of iron ions responsible for the K emission is inconsistent with that of the ions responsible for the lower-energy lines, and the flux of the highest-energy X-rays is underestimated. The iron K line and the high-energy continuum could arise from the same INE component, but the identification of this component with either the blast wave or the ejecta in the standard model is difficult. In Tycho, the high-energy data rule out a class of models for the lower-energy data which have too large a continuum contribution.

  19. Protoparvovirus Knocking at the Nuclear Door.

    Science.gov (United States)

    Mäntylä, Elina; Kann, Michael; Vihinen-Ranta, Maija

    2017-10-02

    Protoparvoviruses target the nucleus due to their dependence on the cellular reproduction machinery during the replication and expression of their single-stranded DNA genome. In recent years, our understanding of the multistep process of the capsid nuclear import has improved, and led to the discovery of unique viral nuclear entry strategies. Preceded by endosomal transport, endosomal escape and microtubule-mediated movement to the vicinity of the nuclear envelope, the protoparvoviruses interact with the nuclear pore complexes. The capsids are transported actively across the nuclear pore complexes using nuclear import receptors. The nuclear import is sometimes accompanied by structural changes in the nuclear envelope, and is completed by intranuclear disassembly of capsids and chromatinization of the viral genome. This review discusses the nuclear import strategies of protoparvoviruses and describes its dynamics comprising active and passive movement, and directed and diffusive motion of capsids in the molecularly crowded environment of the cell.

  20. Genetic algorithm for building envelope calibration

    International Nuclear Information System (INIS)

    Ramos Ruiz, Germán; Fernández Bandera, Carlos; Gómez-Acebo Temes, Tomás; Sánchez-Ostiz Gutierrez, Ana

    2016-01-01

    Highlights: • Calibration methodology using Multi-Objective Genetic Algorithm (NSGA-II). • Uncertainty analysis formulas implemented directly in EnergyPlus. • The methodology captures the heat dynamic of the building with a high level of accuracy. • Reduction in the number of parameters involved due to sensitivity analysis. • Cost-effective methodology using temperature sensors only. - Abstract: Buildings today represent 40% of world primary energy consumption and 24% of greenhouse gas emissions. In our society there is growing interest in knowing precisely when and how energy consumption occurs. This means that consumption measurement and verification plans are well-advanced. International agencies such as Efficiency Valuation Organization (EVO) and International Performance Measurement and Verification Protocol (IPMVP) have developed methodologies to quantify savings. This paper presents a methodology to accurately perform automated envelope calibration under option D (calibrated simulation) of IPMVP – vol. 1. This is frequently ignored because of its complexity, despite being more flexible and accurate in assessing the energy performance of a building. A detailed baseline energy model is used, and by means of a metaheuristic technique achieves a highly reliable and accurate Building Energy Simulation (BES) model suitable for detailed analysis of saving strategies. In order to find this BES model a Genetic Algorithm (NSGA-II) is used, together with a highly efficient engine to stimulate the objective, thus permitting rapid achievement of the goal. The result is a BES model that broadly captures the heat dynamic behaviour of the building. The model amply fulfils the parameters demanded by ASHRAE and EVO under option D.

  1. Starquakes, Heating Anomalies, and Nuclear Reactions in the Neutron Star Crust

    Science.gov (United States)

    Deibel, Alex Thomas

    When the most massive stars perish, their cores may remain intact in the form of extremely dense and compact stars. These stellar remnants, called neutron stars, are on the cusp of becoming black holes and reach mass densities greater than an atomic nucleus in their centers. Although the interiors of neutron stars were difficult to investigate at the time of their discovery, the advent of modern space-based telescopes (e.g., Chandra X-ray Observatory) has pushed our understanding of the neutron star interior into exciting new realms. It has been shown that the neutron star interior spans an enormous range of densities and contains many phases of matter, and further theoretical progress must rely on numerical calculations of neutron star phenomena built with detailed nuclear physics input. To further investigate the properties of the neutron star interior, this dissertation constructs numerical models of neutron stars, applies models to various observations of neutron star high-energy phenomena, and draws new conclusions about the neutron star interior from these analyses. In particular, we model the neutron star's outermost ? 1 km that encompasses the neutron star's envelope, ocean, and crust. The model must implement detailed nuclear physics to properly simulate the hydrostatic and thermal structure of the neutron star. We then apply our model to phenomena that occur in these layers, such as: thermonuclear bursts in the envelope, g-modes in the ocean, torsional oscillations of the crust, and crust cooling of neutron star transients. A comparison of models to observations provides new insights on the properties of dense matter that are often difficult to probe through terrestrial experiments. For example, models of the quiescent cooling of neutron stars, such as the accreting transient MAXI J0556-332, at late times into quiescence probe the thermal transport properties of the deep neutron star crust. This modeling provides independent data from astronomical

  2. Flight envelope protection system for unmanned aerial vehicles

    KAUST Repository

    Claudel, Christian G.; Shaqura, Mohammad

    2016-01-01

    Systems and methods to protect the flight envelope in both manual flight and flight by a commercial autopilot are provided. A system can comprise: an inertial measurement unit (IMU); a computing device in data communication with the IMU

  3. Envelope Protection for In-Flight Ice Contamination

    Science.gov (United States)

    Gingras, David R.; Barnhart, Billy P.; Ranaudo, Richard J.; Ratvasky, Thomas P.; Morelli, Eugene A.

    2010-01-01

    Fatal loss-of-control (LOC) accidents have been directly related to in-flight airframe icing. The prototype system presented in this paper directly addresses the need for real-time onboard envelope protection in icing conditions. The combinations of a-priori information and realtime aerodynamic estimations are shown to provide sufficient input for determining safe limits of the flight envelope during in-flight icing encounters. The Icing Contamination Envelope Protection (ICEPro) system has been designed and implemented to identify degradations in airplane performance and flying qualities resulting from ice contamination and provide safe flight-envelope cues to the pilot. Components of ICEPro are described and results from preliminary tests are presented.

  4. that Bind Specifically to Recombinant Envelope Protein of Dengue

    African Journals Online (AJOL)

    Tropical Journal of Pharmaceutical Research June 2015; 14 (6): 997-1003 ... Revised accepted: 30 April 2015. Abstract ... Results: The 45 KDa, 43 KDa and 30 KDa plasma membrane proteins were identified as viral envelope targets.

  5. Transport of Ions Across the Inner Envelope Membrane of Chloroplasts

    International Nuclear Information System (INIS)

    McCarty, R. E.

    2004-01-01

    The technical report outlines the results of nine years of research on how ions cross the inner envelope membrane of chloroplasts. The ions include protons, nitrite, calcium and ferrous iron. Bicarbonate transport was also studied

  6. Intelligent building envelopes. Architectural concept and applications for daylighting quality

    Energy Technology Data Exchange (ETDEWEB)

    Wyckmans, Annemie

    2005-11-15

    How does an intelligent building envelope manage the variable and sometimes conflictive occupant requirements that arise in a day lit indoor environment. This is the research question that provides the basis for this Ph.D. work. As it touches upon several fields of application, the research question is untangled into four steps, each of which corresponds to a chapter of the thesis. 1) What characterises intelligent behaviour for a building envelope. 2) What characterises indoor day lighting quality. 3) Which functions can an intelligent building envelope be expected to perform in the context of day lighting quality. 4) How are the materials, components and composition of an intelligent building envelope designed to influence this performance. The emphasis is on design, environmental aspects, energy conservation, functional analysis and physical applications.

  7. Early localization of NPA58, a rat nuclear pore-associated protein, to ...

    Indian Academy of Sciences (India)

    Unknown

    Mitotic reassembly; nuclear envelope assembly; nuclear pore complex ... A consensus model for the vertebrate NPC based on ... A mouse monoclonal antibody to PCNA (PC10) a protein associ- ated with DNA replication centres during S ...

  8. Aspherical Dust Envelopes Around Oxygen-Rich AGB Stars

    Directory of Open Access Journals (Sweden)

    Kyung-Won Suh

    2006-12-01

    Full Text Available We model the aspherical dust envelopes around O-rich AGB stars. We perform the radiative transfer model calculations for axisymmetric dust distributions. We simulate what could be observed from the aspherical dust envelopes around O-rich AGB stars by presenting the model spectral energy distributions and images at various wavelengths for different optical depths and viewing angles. The model results are very different from the ones with spherically symmetric geometry.

  9. Failure envelope approach for consolidated undrained capacity of shallow foundations

    OpenAIRE

    Vulpe, Cristina; Gourvenec, Susan; Leman, Billy; Fung, Kah Ngii

    2016-01-01

    A generalized framework is applied to predict consolidated undrained VHM failure envelopes for surface circular and strip foundations. The failure envelopes for consolidated undrained conditions are shown to be scaled from those for unconsolidated undrained conditions by the uniaxial consolidated undrained capacities, which are predicted through a theoretical framework based on fundamental critical state soil mechanics. The framework is applied to results from small-strain finite-element anal...

  10. The majority of lipoprotein lipase in plasma is bound to remnant lipoproteins: A new definition of remnant lipoproteins.

    Science.gov (United States)

    Sato, Koichi; Okajima, Fumikazu; Miyashita, Kazuya; Imamura, Shigeyuki; Kobayashi, Junji; Stanhope, Kimber L; Havel, Peter J; Machida, Tetsuo; Sumino, Hiroyuki; Murakami, Masami; Schaefer, Ernst; Nakajima, Katsuyuki

    2016-10-01

    Lipoprotein lipase (LPL) is a multifunctional protein and a key enzyme involved in the regulation of lipoprotein metabolism. We determined the lipoproteins to which LPL is bound in the pre-heparin and post-heparin plasma. Tetrahydrolipstatin (THL), a potent inhibitor of serine lipases, was used to block the lipolytic activity of LPL, thereby preventing changes in the plasma lipoproteins due to ex vivo lipolysis. Gel filtration was performed to obtain the LPL elution profiles in plasma and the isolated remnant lipoproteins (RLP). When ex vivo lipolytic activity was inhibited by THL in the post-heparin plasma, majority of the LPL was found in the VLDL elution range, specifically in the RLP as inactive dimers. However, in the absence of THL, most of the LPL was found in the HDL elution range as active dimers. Furthermore, majority of the LPL in the pre-heparin plasma was found in the RLP as inactive form, with broadly diffused lipoprotein profiles in the presence and absence of THL. It is suggested that during lipolysis in vivo, the endothelial bound LPL dimers generates RLP, forming circulating RLP-LPL complexes in an inactive form that subsequently binds and initiates receptor-mediated catabolism. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. Preserving Envelope Efficiency in Performance Based Code Compliance

    Energy Technology Data Exchange (ETDEWEB)

    Thornton, Brian A. [Thornton Energy Consulting (United States); Sullivan, Greg P. [Efficiency Solutions (United States); Rosenberg, Michael I. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Baechler, Michael C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-06-20

    The City of Seattle 2012 Energy Code (Seattle 2014), one of the most progressive in the country, is under revision for its 2015 edition. Additionally, city personnel participate in the development of the next generation of the Washington State Energy Code and the International Energy Code. Seattle has pledged carbon neutrality by 2050 including buildings, transportation and other sectors. The United States Department of Energy (DOE), through Pacific Northwest National Laboratory (PNNL) provided technical assistance to Seattle in order to understand the implications of one potential direction for its code development, limiting trade-offs of long-lived building envelope components less stringent than the prescriptive code envelope requirements by using better-than-code but shorter-lived lighting and heating, ventilation, and air-conditioning (HVAC) components through the total building performance modeled energy compliance path. Weaker building envelopes can permanently limit building energy performance even as lighting and HVAC components are upgraded over time, because retrofitting the envelope is less likely and more expensive. Weaker building envelopes may also increase the required size, cost and complexity of HVAC systems and may adversely affect occupant comfort. This report presents the results of this technical assistance. The use of modeled energy code compliance to trade-off envelope components with shorter-lived building components is not unique to Seattle and the lessons and possible solutions described in this report have implications for other jurisdictions and energy codes.

  12. Analyzing Data Remnant Remains on User Devices to Determine Probative Artifacts in Cloud Environment.

    Science.gov (United States)

    Ahmed, Abdulghani Ali; Xue Li, Chua

    2018-01-01

    Cloud storage service allows users to store their data online, so that they can remotely access, maintain, manage, and back up data from anywhere via the Internet. Although helpful, this storage creates a challenge to digital forensic investigators and practitioners in collecting, identifying, acquiring, and preserving evidential data. This study proposes an investigation scheme for analyzing data remnants and determining probative artifacts in a cloud environment. Using pCloud as a case study, this research collected the data remnants available on end-user device storage following the storing, uploading, and accessing of data in the cloud storage. Data remnants are collected from several sources, including client software files, directory listing, prefetch, registry, network PCAP, browser, and memory and link files. Results demonstrate that the collected remnants data are beneficial in determining a sufficient number of artifacts about the investigated cybercrime. © 2017 American Academy of Forensic Sciences.

  13. Remnant pancreatic parenchymal volume predicts postoperative pancreatic exocrine insufficiency after pancreatectomy.

    Science.gov (United States)

    Okano, Keisuke; Murakami, Yoshiaki; Nakagawa, Naoya; Uemura, Kenichiro; Sudo, Takeshi; Hashimoto, Yasushi; Kondo, Naru; Takahashi, Shinya; Sueda, Taijiro

    2016-03-01

    Pancreatectomy, including pancreatoduodenectomy and distal pancreatectomy, often causes postoperative pancreatic exocrine insufficiency (PEI). Our aim was to clarify a relationship between remnant pancreatic volume and postoperative PEI. A total of 227 patients who underwent pancreatoduodenectomy or distal pancreatectomy were enrolled in this study. All patients underwent a (13)C-labeled mixed triglyceride breath test to assess pancreatic exocrine function and abdominal dynamic computed tomography for assessing remnant pancreatic volume after pancreatectomy at a median of 7 months postoperatively. The percent (13)CO2 cumulative dose at 7 hours (% dose (13)C cum 7 h) pancreatectomy were performed in 174 (76.7%) and 53 (23.3%) patients, respectively. Of the 227 patients, 128 (56.3%) developed postoperative PEI. Postoperative % dose (13)C cum 7 h was strongly correlated with remnant pancreatic volume (r = .509, P pancreatectomy (P pancreatectomy. Remnant pancreatic volume may predict postoperative PEI in patients who undergo pancreatectomy. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Remnant for all black objects due to gravity's rainbow

    Energy Technology Data Exchange (ETDEWEB)

    Ali, Ahmed Farag, E-mail: afarag@zewailcity.edu.eg [Department of Physics, Florida State University, Tallahassee, FL 32306 (United States); Center for Fundamental Physics, Zewail City of Science and Technology, Giza 12588 (Egypt); Department of Physics, Faculty of Science, Benha University, Benha 13518 (Egypt); Faizal, Mir, E-mail: f2mir@uwaterloo.ca [Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario, N2L 3G1 (Canada); Khalil, Mohammed M., E-mail: moh.m.khalil@gmail.com [Department of Electrical Engineering, Alexandria University, Alexandria 12544 (Egypt)

    2015-05-15

    We argue that a remnant is formed for all black objects in gravity's rainbow. This will be based on the observation that a remnant depends critically on the structure of the rainbow functions, and this dependence is a model independent phenomena. We thus propose general relations for the modified temperature and entropy of all black objects in gravity's rainbow. We explicitly check this to be the case for Kerr, Kerr–Newman-dS, charged-AdS, and higher dimensional Kerr–AdS black holes. We also try to argue that a remnant should form for black saturn in gravity's rainbow. This work extends our previous results on remnants of Schwarzschild black holes and black rings.

  15. Remnant cholesterol as a causal risk factor for ischemic heart disease

    DEFF Research Database (Denmark)

    Varbo, Anette; Benn, Marianne; Tybjærg-Hansen, Anne

    2013-01-01

    The aim of this study was to test the hypothesis that elevated nonfasting remnant cholesterol is a causal risk factor for ischemic heart disease independent of reduced high-density lipoprotein (HDL) cholesterol.......The aim of this study was to test the hypothesis that elevated nonfasting remnant cholesterol is a causal risk factor for ischemic heart disease independent of reduced high-density lipoprotein (HDL) cholesterol....

  16. STAR FORMATION ASSOCIATED WITH THE SUPERNOVA REMNANT IC443

    International Nuclear Information System (INIS)

    Xu Jinlong; Wang Junjie; Miller, Martin

    2011-01-01

    We have performed submillimeter and millimeter observations in CO lines toward supernova remnant (SNR) IC443. The CO molecular shell coincides well with the partial shell of the SNR detected in radio continuum observations. Broad emission lines and three 1720 MHz OH masers were detected in the CO molecular shell. The present observations have provided further evidence in support of the interaction between the SNR and the adjoining molecular clouds (MCs). The total mass of the MCs is 9.26 x 10 3 M sun . The integrated CO line intensity ratio (R I CO(3-2) /I CO(2-1) ) for the whole MC is between 0.79 and 3.40. The average value is 1.58, which is much higher than previous measurements of individual Galactic MCs. Higher line ratios imply that shocks have driven into the MCs. We conclude that high R I CO(3-2) /I CO(2-1) is identified as a good signature of the SNR-MC interacting system. Based on the IRAS Point Source Catalog and the Two Micron All Sky Survey near-infrared database, 12 protostellar object and 1666 young stellar object (YSO) candidates (including 154 classical T Tauri stars and 419 Herbig Ae/Be stars) are selected. In the interacting regions, the significant enhancement of the number of protostellar objects and YSOs indicates the presence of some recently formed stars. After comparing the characteristic timescales of star formation with the age of IC443, we conclude that the protostellar objects and YSO candidates are not triggered by IC443. For the age of the stellar winds shell, we have performed our calculation on the basis of a stellar wind shell expansion model. The results and analysis suggest that the formation of these stars may be triggered by the stellar winds of the IC443 progenitor.

  17. Remnant radio-loud AGN in the Herschel-ATLAS field

    Science.gov (United States)

    Mahatma, V. H.; Hardcastle, M. J.; Williams, W. L.; Brienza, M.; Brüggen, M.; Croston, J. H.; Gurkan, G.; Harwood, J. J.; Kunert-Bajraszewska, M.; Morganti, R.; Röttgering, H. J. A.; Shimwell, T. W.; Tasse, C.

    2018-04-01

    Only a small fraction of observed active galactic nuclei (AGN) display large-scale radio emission associated with jets, yet these radio-loud AGN have become increasingly important in models of galaxy evolution. In determining the dynamics and energetics of the radio sources over cosmic time, a key question concerns what happens when their jets switch off. The resulting `remnant' radio-loud AGN have been surprisingly evasive in past radio surveys, and therefore statistical information on the population of radio-loud AGN in their dying phase is limited. In this paper, with the recent developments of Low-Frequency Array (LOFAR) and the Very Large Array, we are able to provide a systematically selected sample of remnant radio-loud AGN in the Herschel-ATLAS field. Using a simple core-detection method, we constrain the upper limit on the fraction of remnants in our radio-loud AGN sample to 9 per cent, implying that the extended lobe emission fades rapidly once the core/jets turn off. We also find that our remnant sample has a wide range of spectral indices (-1.5≤slant α ^{1400}_{150}≤slant -0.5), confirming that the lobes of some remnants may possess flat spectra at low frequencies just as active sources do. We suggest that, even with the unprecedented sensitivity of LOFAR, our sample may still only contain the youngest of the remnant population.

  18. NGC 2782: A Merger Remnant with Young Stars in its Gaseous Tidal Tail

    Science.gov (United States)

    Torres-Flores, S.; de Oliveira, C. Mendes; de Mello, D. F.; Scarano, S. Jr.; Urrutia-Viscarra, R.

    2012-01-01

    We have searched for young star-forming regions around the merger remnant NGC 2782. By using GALEX FUV and NUV imaging and HI data we found seven UV sources, located at distances greater than 26 kpc from the center of NGG 2782, and coinciding with its western HI tidal tail. These regions were resolved in several smaller systems when Gemini/GMOS r-band images were used. We compared the observed colors to stellar population synthesis models and we found that these objects have ages of l to ll11yr and masses ranging from 10(exp 3.9) to l0(exp 4.6) Solar Mass. By using Gemini/GMOS spectroscopic data we confirm memberships and derive high metallicities for three of the young regions in the tail (12+log(O/H)=8.74+/-0.20, 8.81+/-0.20 and 8.78+/-0.20). These metallicities are similar to the value presented by the nuclear region of NGG 2782 and also similar to the value presented for an object located close to the main body of NGG 2782. The high metallicities measured for the star-forming regions in the gaseous tidal tail of NGG 2782 could be explained if they were formed out of highly enriched gas which was once expelled from the center of the merging galaxies when the system collided. An additional possibility is that the tail has been a nursery of a few generations of young stellar systems which ultimately polluted this medium with metals, further enriching the already pre-enriched gas ejected to the tail when the galaxies collided.

  19. Integrated energy design of the building envelope

    Energy Technology Data Exchange (ETDEWEB)

    Vraa Nielsen, M.

    2012-07-01

    This thesis describes the outcome of the PhD project Integrated energy design of the building envelope carried out through a combination of scientific dissemination reported through peer-reviewed journals and a wide range of affiliated projects involved in at an architectural firm. The research project analysed how the implementation of technical knowledge early in the building design process can quantify the effect of a building's facades on its energy efficiency and indoor climate and thereby facilitate a more qualified design development. The project was structured in the following way: 1) the importance of integrating knowledge in the early stages of design, and how it can be done; 2) understanding the facade's typology; and 3) the complex notion of comfort. The project touched not only on the technical capabilities and requirements governing facade design, but also the process by which it takes place. This was done by applying the methodology of Integrated Energy Design (IED) and analysing its applicability in the design of facades. A major part of the project was an actual engagement in the architectural process to test out incorporating a consciousness about energy and comfort as part of a more holistic performance evaluation. The research project illustrates the great potential in taking passive properties into account through a geometrical optimisation inherent in the development of the architectural concept. It demonstrates that integration of technical knowledge at the early stages of design not only can qualify the geometrical processing, but also facilitate the design development of the facade. Thereby a more holistic performance optimisation can be obtained through parameters such as overall facade geometry and orientation, functional organisation, room height and depth, facade layout, window geometry and transparency, design of the window aperture, etc. Through the wide range of affiliated project involved in at the architectural firm over

  20. Impact of chronic lymphocytic thyroiditis co-existing with differentiated thyroid cancer on the effectiveness of remnants ablation

    International Nuclear Information System (INIS)

    Boughattas, S.; Chatti, K.; Trimeche, M.; Mokni, M.

    2004-01-01

    Full text: Some stages of chronic lymphocytic thyroiditis (CLT) are functionally characterized by an organification defect with large intra thyroid inorganic iodide pool, which can be discharged during perchlorate test. Fluorescent scan study indicates that most patients with CLT have decreased stable iodine store in the thyroid gland. The aim of our study was to investigate the possible consequences of these organification abnormalities during remnants ablation in patients with coexisting differentiated thyroid cancer (DTC) and chronic lymphocytic thyroiditis. We reviewed our series of patients of DTC being followed at the department of nuclear medicine of the university hospital Sahloul. Among the 350 patients with DTC, 30 (8.5%) had histologically proved chronic lymphocytic thyroiditis, with infiltration of the non-tumoral thyroid tissue. A second group of 60 patients (without evidence of lymphocytic infiltration) was selected randomly and used as control. The median of follow-up for these two groups was 4 years. All patients had undergone total thyroidectomy followed by scintigraphy 4-6 weeks later. In patients with thyroid remnants, standard ablative dose of 3.7 GBq of I-131 (100 mCi) was administrated with 6 months duration between all therapies, until the negativity of thyroid bed activity on follow up survey scan performed 48 to 72 hours after administering 2 to 3 mCi of I-131. Thyroglobulin (Tg) serum level was not considered as a criterion of ablation, because of the frequency of anti-thyroid antibodies in CLT. In the group with CLT, 3 patients had negative postoperative neck scintigraphy. Complete ablation was achieved with a single standard dose in 14, two standard doses in 5, and more than 200 mCi in two patients (300 in one and 400 in two). In five patients, ablation is not yet achieved. In the control group, ablation was obtained with 100 mCi in 43 patients, 200 mCi in 9, and 300 mCi in 3. In five patients ablation has not been achieved. Considering

  1. The South Carolina bridge-scour envelope curves

    Science.gov (United States)

    Benedict, Stephen T.; Feaster, Toby D.; Caldwell, Andral W.

    2016-09-30

    The U.S. Geological Survey, in cooperation with the South Carolina Department of Transportation, conducted a series of three field investigations to evaluate historical, riverine bridge scour in the Piedmont and Coastal Plain regions of South Carolina. These investigations included data collected at 231 riverine bridges, which lead to the development of bridge-scour envelope curves for clear-water and live-bed components of scour. The application and limitations of the South Carolina bridge-scour envelope curves were documented in four reports, each report addressing selected components of bridge scour. The current investigation (2016) synthesizes the findings of these previous reports into a guidance manual providing an integrated procedure for applying the envelope curves. Additionally, the investigation provides limited verification for selected bridge-scour envelope curves by comparing them to field data collected outside of South Carolina from previously published sources. Although the bridge-scour envelope curves have limitations, they are useful supplementary tools for assessing the potential for scour at riverine bridges in South Carolina.

  2. Solar envelope concepts: moderate density building applications. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Knowles, R.L.; Berry, R.D.

    1980-04-01

    Solar energy utilization in urban areas requires public guarantees that all property owners have direct access to the sun. The study examines the implications of this premise in relation to the need for cities to also encourage or accommodate rebuilding and future development. The public policy mechanism for guaranteeing solar access is conceptualized as a solar zoning envelope that allows the largest possible building bulk on a land parcel without shadowing neighboring properties during specified times. Step-by-step methods for generating solar envelopes are described with extensive drawings, showing a variety of urban platting and lot configurations. Development and design possibilities are examined on a selected set of Los Angeles sites with typically diverse urban characteristics. Envelope attributes suitable for encouraging moderate-density commercial and residential building are examined in the context of two hypothetical but realistic development programs: one for speculative office buildings and one for condominium housing. Numerous illustrations of envelope forms and prototypical building designs are provided. The results of development simulation studies on all test sites are tabulated to show building bulk, density, land-coverage and open space characteristics obtainable under the hypothesized envelopes.

  3. Symmetry remnants in the face of competing interactions in nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Leviatan, A., E-mail: ami@phys.huji.ac.il [Racah Institute of Physics, The Hebrew University, Jerusalem 91904 (Israel); Macek, M., E-mail: michal.macek@yale.edu [Center for Theoretical Physics, Sloane Physics Laboratory, Yale University, New Haven, CT 06520-8120 (United States)

    2015-10-15

    Detailed description of nuclei necessitates model Hamiltonians which break most dynamical symmetries. Nevertheless, generalized notions of partial and quasi dynamical symmetries may still be applicable to selected subsets of states, amidst a complicated environment of other states. We examine such scenarios in the context of nuclear shape-phase transitions.

  4. High frequency vibration analysis by the complex envelope vectorization.

    Science.gov (United States)

    Giannini, O; Carcaterra, A; Sestieri, A

    2007-06-01

    The complex envelope displacement analysis (CEDA) is a procedure to solve high frequency vibration and vibro-acoustic problems, providing the envelope of the physical solution. CEDA is based on a variable transformation mapping the high frequency oscillations into signals of low frequency content and has been successfully applied to one-dimensional systems. However, the extension to plates and vibro-acoustic fields met serious difficulties so that a general revision of the theory was carried out, leading finally to a new method, the complex envelope vectorization (CEV). In this paper the CEV method is described, underlying merits and limits of the procedure, and a set of applications to vibration and vibro-acoustic problems of increasing complexity are presented.

  5. Safety analysis to support a safe operating envelope for fuel

    International Nuclear Information System (INIS)

    Gibb, R.A.; Reid, P.J.

    1998-01-01

    This paper presents an approach for defining a safe operating envelope for fuel. 'Safe operating envelope' is defined as an envelope of fuel parameters defined for application in safety analysis that can be related to, or used to define, the acceptable range of fuel conditions due to operational transients or deviations in fuel manufacturing processes. The paper describes the motivation for developing such a methodology. The methodology involved four steps: the update of fission product inventories, the review of sheath failure criteria, a review of input parameters to be used in fuel modelling codes, and the development of an improved fission product release code. This paper discusses the aspects of fuel sheath failure criteria that pertain to operating or manufacturing conditions and to the evaluation and selection of modelling input data. The other steps are not addressed in this paper since they have been presented elsewhere. (author)

  6. The presence of dysplastic nevus remnants in malignant melanomas. A population-based study of 551 malignant melanomas.

    Science.gov (United States)

    Hastrup, N; Osterlind, A; Drzewiecki, K T; Hou-Jensen, K

    1991-08-01

    We examined 512 malignant melanomas, representing all newly diagnosed cutaneous malignant melanomas, excluding lentigo maligna melanomas, from the period October 1, 1982 to March 31, 1985 occurring in the region of eastern Denmark in patients aged 20-79 years for the presence of dysplastic nevus remnants. Criteria for the diagnosis of a dysplastic nevus remnant include all the following changes (a) lentiginous or epithelioid melanocyte hyperplasia, (b) cytologic melanocyte atypia, (c) eosinophilic fibroplasia, (d) lamellar fibroplasia, and (e) lymphocytic infiltration in the dermis. Dysplastic nevus remnants were found in association with 34 (7%) of the evaluable 512 malignant melanomas. Fourteen (41%) of the remnants were of compound nevus type. In nine (27%) of the remnants, atypia was pronounced. Most (62%) dysplastic nevus remnants were contiguous to thin superficial spreading melanomas. We conclude from this population-based study that about 7% of malignant melanomas arise in prior dysplastic nevi.

  7. Envelope proteins of bovine herpesvirus 1: immunological and biochemical studies

    International Nuclear Information System (INIS)

    Rodriguez Roque, L.L.

    1986-01-01

    The authors studied immunological and biochemical properties of the bovid herpesvirus 1 (BHV-1) envelope proteins in order to understand the pathogenesis of BHV-1 infection and to provide basic information for the production of effective subunit vaccines against BHV-1. Ten glycoproteins MW 180, 150, 130, 115, 97, 77, 74, 64, 55, and 45 kilodaltons (K), and a single non-glycosylated 108 K protein were quantitatively removed from purified BHV-1 virions by detergent treatment. These glycoproteins were present on the virion envelope and on the surface of BHV-1 infected cells. The quantitative removal from virions by treatment with nonionic detergents and their presence on the surface of infected cells indicate that 180/97, 150/77, and 130/74/55 K are major components of the BHV-1 envelope and are also the targets of virus neutralizing humoral immune response. Envelope glycoproteins of herpes simplex type 1 (HSV-1) bind immunoglobulin by the Fc end and it is suggested this may increase pathogenicity of this virus. They searched for a similar function in BVH-1 by measuring the ability of BHV-1 infected cells and viral envelope proteins to bind radiolabelled rabbit and bovine IgG. Binding activity for rabbit IgG or bovine IgG-Fc could not be demonstrated by BHV-1 infected MDBK cells, whereas, MDBK cells infected with HSV-1 bound rabbit IgG and bovine IgG-Fc. None of the three major envelope proteins of BHV-1 bound to rabbit or bovine IgG. The results of this study indicate that BHV-1, unlike some other herpesviruses, lack Fc binding activity

  8. [ARTHROSCOPIC STUDY OF REMNANT-PRESERVED RECONSTRUCTION OF ANTERIOR CRUCIATE LIGAMENT].

    Science.gov (United States)

    Lu, Daifeng; Xiao, Mochao; Zhang, Yunpeng; Yan, Shi; Dong, Feng; Lian, Yongyun

    2015-08-01

    To investigate the value of ligament remnant preservation during anterior cruciate ligament (ACL) reconstruction by observing the integrity, the tension, the synovial membrane covering, and the color of the reconstructed ligament under arthroscopy. Between January 2011 and December 2013, 122 patients who underwent ACL reconstruction and arthroscopic internal fixation removal at 1 year after reconstruction were included in this study. Of these cases, 61 cases underwent ACL reconstruction using the remnant-preserved technique (preservation group); the other 61 cases underwent ACL reconstruction using non remnant-preserved technique (non preservation group). There was no significant difference in gender, age, injury side, body mass index, type of injury, the time from injury to reconstruction, and the result of KT-2000 examination between 2 groups (P > 0.05). The reconstructed ACL were observed under arthroscopy when internal fixation was removed, and the effectiveness was evaluated according to the criteria of AO Yingfang. In preservation group, the results were excellent in 34 cases, good in 22 cases, fair in 4 cases, and poor in 1 case; and in non preservation group, the results were excellent in 29 cases, good in 20 cases, fair in 10 cases, and poor in 2 cases; and there was no significant difference between 2 groups (Z= -1.320, P=0.187). In ACL reconstruction, the remnant-preserved technique is not obviously better than non remnant-preserved technique in the integrity, tension, membrane covering, and color.

  9. THE ABSENCE OF EX-COMPANIONS IN TYPE Ia SUPERNOVA REMNANTS

    Energy Technology Data Exchange (ETDEWEB)

    Di Stefano, R. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Kilic, Mukremin, E-mail: rd@cfa.harvard.edu, E-mail: kilic@ou.edu [Homer L. Dodge Department of Physics and Astronomy, University of Oklahoma, 440 West Brooks Street, Norman, OK 73019 (United States)

    2012-11-01

    Type Ia supernovae (SNe Ia) play important roles in our study of the expansion and acceleration of the universe, but because we do not know the exact nature or natures of the progenitors, there is a systematic uncertainty that must be resolved if SNe Ia are to become more precise cosmic probes. No progenitor system has ever been identified either in the pre- or post-explosion images of a Ia event. There have been recent claims for and against the detection of ex-companion stars in several SNe Ia remnants. These studies, however, usually ignore the angular momentum gain of the progenitor white dwarf (WD), which leads to a spin-up phase and a subsequent spin-down phase before explosion. For spin-down timescales greater than 10{sup 5} years, the donor star could be too dim to detect by the time of explosion. Here we revisit the current limits on ex-companion stars to SNR 0509-67.5, a 400-year-old remnant in the Large Magellanic Cloud. If the effects of possible angular momentum gain on the WD are included, a wide range of single-degenerate progenitor models are allowed for this remnant. We demonstrate that the current absence of evidence for ex-companion stars in this remnant, as well as other SNe Ia remnants, does not necessarily provide the evidence of absence for ex-companions. We discuss potential ways to identify such ex-companion stars through deep imaging observations.

  10. THE ABSENCE OF EX-COMPANIONS IN TYPE Ia SUPERNOVA REMNANTS

    International Nuclear Information System (INIS)

    Di Stefano, R.; Kilic, Mukremin

    2012-01-01

    Type Ia supernovae (SNe Ia) play important roles in our study of the expansion and acceleration of the universe, but because we do not know the exact nature or natures of the progenitors, there is a systematic uncertainty that must be resolved if SNe Ia are to become more precise cosmic probes. No progenitor system has ever been identified either in the pre- or post-explosion images of a Ia event. There have been recent claims for and against the detection of ex-companion stars in several SNe Ia remnants. These studies, however, usually ignore the angular momentum gain of the progenitor white dwarf (WD), which leads to a spin-up phase and a subsequent spin-down phase before explosion. For spin-down timescales greater than 10 5 years, the donor star could be too dim to detect by the time of explosion. Here we revisit the current limits on ex-companion stars to SNR 0509-67.5, a 400-year-old remnant in the Large Magellanic Cloud. If the effects of possible angular momentum gain on the WD are included, a wide range of single-degenerate progenitor models are allowed for this remnant. We demonstrate that the current absence of evidence for ex-companion stars in this remnant, as well as other SNe Ia remnants, does not necessarily provide the evidence of absence for ex-companions. We discuss potential ways to identify such ex-companion stars through deep imaging observations.

  11. Hot gas in the interstellar medium, from supernova remnants to the diffuse coronal phase

    International Nuclear Information System (INIS)

    Ballet, Jean

    1988-01-01

    This research thesis addresses the study of the hot interstellar medium and of its main component, supernovae remnants. The author studied the hypothesis according to which ions observed in the interstellar medium are produced during the evaporation of cold clouds in the coronal phase. He shows that effects of ionisation delay are important and modify by a factor 10 the total quantity of ions predicted by the model. The study of the influence on ionisation of hot electrons penetrating cold layers revealed that this effect is rather weak. Then, based on the observation of the Kepler supernovae remnants by means of EXOSAT, and on the use of a hydrodynamics code coupled with a step-by-step calculation of ionisation of elements, the author studied the evolution of young supernovae remnants: propagation of the main shock in the interstellar medium, and of the backlash in the matter ejected by the star. The author also studied the X emission of an older supernovae remnant (the Cygnus Loop) by analysing three EXOSAT observations of this remnant. Results of Fabry-Perot spectrophotometry have been used to study optic lines [fr

  12. The role of small woodland remnants on ground dwelling insect conservation in Chaco Serrano, Central Argentina.

    Science.gov (United States)

    Moreno, María Laura; Fernández, María Guadalupe; Molina, Silvia Itati; Valladares, Graciela

    2013-01-01

    Many terrestrial ecosystems are changing due to extensive land use and habitat fragmentation, posing a major threat to biodiversity. In this study, the effects of patch size, isolation, and edge/interior localization on the ground dwelling insect communities in the Chaco Serrano woodland remnants in central Argentina were examined. Sampling was carried out in December 2003 and March 2004 in nine remnants (0.57 to 1000 hectares) using pitfall traps. In total, 7071 individuals representing 12 orders and 79 families were recorded. The taxonomic composition of these communities was linked to remnant size. Insect abundance increased (as did their richness, albeit marginally) as remnant area decreased, with no significant effects of isolation or edge/interior localization on abundance, richness, or diversity. No differential area effects were observed when abundance and richness of predators, scavengers, and herbivores were compared. Thus, ground insect communities in fragmented Chaco Serrano seem to respond mainly to patch level, rather than to within-patch (edge effects) or landscape (isolation) level variables. These results suggest that small Chaco Serrano remnants, by supporting larger ground-dwelling insect assemblages, may play an important role from a conservation viewpoint.

  13. Entirely Laparoscopic Gastrectomy and Colectomy for Remnant Gastric Cancer with Gastric Outlet Obstruction and Transverse Colon Invasion

    OpenAIRE

    Kim, Hyun Il; Kim, Min Gyu

    2015-01-01

    It is well known that gastrectomy with curative intent is the best way to improve outcomes of patients with remnant gastric cancer. Recently,several investigators reported their experiences with laparoscopic gastrectomy of remnant gastric cancer. We report the case of an 83-year-old female patient who was diagnosed with remnant gastric cancer with obstruction. She underwent an entirely laparoscopic distal gastrectomy with colectomy because of direct invasion of the transverse colon. The opera...

  14. Enveloping algebras of Lie groups with descrete series

    International Nuclear Information System (INIS)

    Nguyen huu Anh; Vuong manh Son

    1990-09-01

    In this article we shall prove that the enveloping algebra of the Lie algebra of some unimodular Lie group having discrete series, when localized at some element of the center, is isomorphic to the tensor product of a Weyl algebra over the ring of Laurent polynomials of one variable and the enveloping algebra of some reductive Lie algebra. In particular, it will be proved that the Lie algebra of a unimodular solvable Lie group having discrete series satisfies the Gelfand-Kirillov conjecture. (author). 6 refs

  15. Constant envelope OFDM scheme for 6PolSK-QPSK

    Science.gov (United States)

    Li, Yupeng; Ding, Ding

    2018-03-01

    A constant envelope OFDM scheme with phase modulator (PM-CE-OFDM) for 6PolSK-QPSK modulation was demonstrated. Performance under large fiber launch power is measured to check its advantages in counteracting fiber nonlinear impairments. In our simulation, PM-CE-OFDM, RF-assisted constant envelope OFDM (RF-CE-OFDM) and conventional OFDM (Con-OFDM) are transmitted through 80 km standard single mode fiber (SSMF) single channel and WDM system. Simulation results confirm that PM-CE-OFDM has best performance in resisting fiber nonlinearity. In addition, benefiting from the simple system structure, the complexity and cost of PM-CE-OFDM system could be reduced effectively.

  16. Data Envelopment Analysis (DEA) Model in Operation Management

    Science.gov (United States)

    Malik, Meilisa; Efendi, Syahril; Zarlis, Muhammad

    2018-01-01

    Quality management is an effective system in operation management to develops, maintains, and improves quality from groups of companies that allow marketing, production, and service at the most economycal level as well as ensuring customer satisfication. Many companies are practicing quality management to improve their bussiness performance. One of performance measurement is through measurement of efficiency. One of the tools can be used to assess efficiency of companies performance is Data Envelopment Analysis (DEA). The aim of this paper is using Data Envelopment Analysis (DEA) model to assess efficiency of quality management. In this paper will be explained CCR, BCC, and SBM models to assess efficiency of quality management.

  17. Asymmetry of the envelope of supernova 1987A

    Energy Technology Data Exchange (ETDEWEB)

    Papaliolios, C.; Karovska, M.; Koechlin, L.; Nisenson, P.; Standley, C.; Heathcote, S.

    1989-04-13

    The supernova SN1987A in the Large Magellanic Cloud has been observed by high-angular-resolution speckle interferometry since 25 March (30 days after the explosion) with the 4-m telescope at the Cerro Tololo Interamerican Observatory. Data obtained on 25 March and 2 April 1987 revealed a second bright 'companion' source separated from the supernova by 60 milliarcseconds and less than three magnitudes fainter than the supernova. Measurements of the average diameter of the supernova envelope have been made from data recorded from March 1987 to April 1988. Here we present a more detailed analysis of these data, which shows that the expanding envelope is asymmetric. (author).

  18. Asymmetry of the envelope of supernova 1987A

    International Nuclear Information System (INIS)

    Papaliolios, C.; Karovska, M.; Koechlin, L.; Nisenson, P.; Standley, C.; Heathcote, S.

    1989-01-01

    The supernova SN1987A in the Large Magellanic Cloud has been observed by high-angular-resolution speckle interferometry since 25 March (30 days after the explosion) with the 4-m telescope at the Cerro Tololo Interamerican Observatory. Data obtained on 25 March and 2 April 1987 revealed a second bright 'companion' source separated from the supernova by 60 milliarcseconds and less than three magnitudes fainter than the supernova. Measurements of the average diameter of the supernova envelope have been made from data recorded from March 1987 to April 1988. Here we present a more detailed analysis of these data, which shows that the expanding envelope is asymmetric. (author)

  19. Calculation of CWKB envelope in boson and fermion productions

    International Nuclear Information System (INIS)

    Biswas, S.; Chowdhury, I.

    2007-01-01

    We present the calculation of envelope of boson and of both low-and high-mass fermion production at the end of inflation when the coherently oscillating inflations decay into bosons and fermions. We consider three different models of inflation and use CWKB technique to calculate the envelope to understand the structure of resonance band formation. We observe that though low-mass fermion production is not effective in preheating because of Pauli blocking, it is quite probable for high-mass fermion to take part in pre heating. (author)

  20. Refractive index dispersion measurement using carrier-envelope phasemeters

    International Nuclear Information System (INIS)

    Hansinger, Peter; Töpfer, Philipp; Adolph, Daniel; Hoff, Dominik; Rathje, Tim; Sayler, A Max; Paulus, Gerhard G; Dimitrov, Nikolay; Dreischuh, Alexander

    2017-01-01

    We introduce a novel method for direct and accurate measurement of refractive index dispersion based on carrier-envelope phase detection of few-cycle laser pulses, exploiting the difference between phase and group velocity in a dispersive medium. In a layout similar to an interferometer, two carrier-envelope phasemeters are capable of measuring the dispersion of a transparent or reflective sample, where one phasemeter serves as the reference and the other records the influence of the sample. Here we report on proof-of-principle measurements that already reach relative uncertainties of a few 10 −4 . Further development is expected to allow for unprecedented precision. (paper)

  1. Sulfur chemistry in the envelope of VY Canis Majoris: Detailed analysis of SO and SO2 emission

    International Nuclear Information System (INIS)

    Adande, G. R.; Edwards, J. L.; Ziurys, L. M.

    2013-01-01

    Detailed radiative transfer modeling has been carried out for SO 2 and SO originating in the envelope of the O-rich supergiant star VY Canis Majoris (VY CMa). A total of 27 transitions of SO 2 and 7 transitions of SO lying in the energy range 3.0-138.2 cm –1 were analyzed using a new non-LTE radiative transfer code that incorporates non-spherical geometries. The spectra were primarily obtained from the Arizona Radio Observatory (ARO) 1 mm spectral survey of VY CMa, conducted with the Submillimeter Telescope; additional lines were measured with the ARO 12 m antenna at 2 and 3 mm. SO 2 and SO were found to arise from five distinct outflows within the envelope, four which are asymmetric with respect to the star. Three flows arise from high-velocity red-shifted material, one from a blue-shifted wind, and the final from a classic 'spherical' expansion. In the spherical component, the peak fractional abundance, relative to H 2 , of both molecules is f ∼ 2.5 × 10 –7 at r ∼ 25 R * , and steadily decreases outward. SO 2 appears to be a 'parent' molecule, formed near the stellar photosphere. In the asymmetric outflows, both SO and SO 2 are more prominent at large stellar radii in dense (10 6 -10 7 cm –3 ), clumpy material, achieving their maximum abundance between 200 and 600 R * with f ∼ 3.0 × 10 –8 -1.5 × 10 –7 . These results suggest that in the collimated outflows, both species are either produced by shock chemistry or are remnant inner shell material swept up in the high-velocity winds.

  2. Sulfur Chemistry in the Envelope of VY Canis Majoris: Detailed Analysis of SO and SO2 Emission

    Science.gov (United States)

    Adande, G. R.; Edwards, J. L.; Ziurys, L. M.

    2013-11-01

    Detailed radiative transfer modeling has been carried out for SO2 and SO originating in the envelope of the O-rich supergiant star VY Canis Majoris (VY CMa). A total of 27 transitions of SO2 and 7 transitions of SO lying in the energy range 3.0-138.2 cm-1 were analyzed using a new non-LTE radiative transfer code that incorporates non-spherical geometries. The spectra were primarily obtained from the Arizona Radio Observatory (ARO) 1 mm spectral survey of VY CMa, conducted with the Submillimeter Telescope; additional lines were measured with the ARO 12 m antenna at 2 and 3 mm. SO2 and SO were found to arise from five distinct outflows within the envelope, four which are asymmetric with respect to the star. Three flows arise from high-velocity red-shifted material, one from a blue-shifted wind, and the final from a classic "spherical" expansion. In the spherical component, the peak fractional abundance, relative to H2, of both molecules is f ~ 2.5 × 10-7 at r ~ 25 R *, and steadily decreases outward. SO2 appears to be a "parent" molecule, formed near the stellar photosphere. In the asymmetric outflows, both SO and SO2 are more prominent at large stellar radii in dense (106-107 cm-3), clumpy material, achieving their maximum abundance between 200 and 600 R * with f ~ 3.0 × 10-8-1.5 × 10-7. These results suggest that in the collimated outflows, both species are either produced by shock chemistry or are remnant inner shell material swept up in the high-velocity winds.

  3. Nuclear and nuclear reprogramming during the first cell cycle in bovine nuclear transfer embryos

    DEFF Research Database (Denmark)

    Østrup, Olga; Petrovicova, Ida; Strejcek, Frantisek

    2009-01-01

    Abstract The immediate events of genomic reprogramming at somatic cell nuclear transfer (SCNT) are to high degree unknown. This study was designed to evaluate the nuclear and nucleolar changes during the first cell cycle. Bovine SCNT embryos were produced from starved bovine fibroblasts and fixed......, somatic cell nuclei introduced into enucleated oocytes displayed chromatin condensation, partial nuclear envelope breakdown, nucleolar desegregation and transcriptional quiescence already at 0.5 hpa. Somatic cell cytoplasm remained temporally attached to introduced nucleus and nucleolus was partially...... restored indicating somatic influence in the early SCNT phases. At 1-3 hpa, chromatin gradually decondensed toward the nucleus periphery and nuclear envelope reformed. From 4 hpa, the somatic cell nucleus gained a PN-like appearance and displayed NPBs suggesting ooplasmic control of development....

  4. Olive oil increases the magnitude of postprandial chylomicron remnants compared to milk fat and safflower oil.

    Science.gov (United States)

    Higashi, K; Ishikawa, T; Shige, H; Tomiyasu, K; Yoshida, H; Ito, T; Nakajima, K; Yonemura, A; Sawada, S; Nakamura, H

    1997-10-01

    The acute effects of olive oil, milk fat and safflower oil on postprandial lipemia and remnant lipoprotein metabolism were investigated. Eight Healthy male volunteers randomly underwent three types of oral fat-vitamin A loading tests. The test drink was a mixture of retinyl palmitate (RP)(50,000 IU of aqueous vitamin A/m2 body surface area) and one of the three types of oils (40 g of fat/m2 body surface area): olive oil (70.7% oleic acid of total fatty acids); milk fat (69.3% saturated fatty acid); safflower oil (74.2% linoleic acid). Olive oil significantly increased plasma triacylglycerol and RP concentrations 4 hours after fat loading, as compared to other fats. Increases of remnant like particle concentrations were higher after olive oil than after the other two fats. These results show that olive oil increases the magnitude of postprandial chylomicrons and chylomicron remnants compared to milk fat and safflower oil.

  5. Three cases of laparoscopic total gastrectomy with intracorporeal esophagojejunostomy for gastric cancer in remnant stomach.

    Science.gov (United States)

    Pan, Yu; Mou, Yi-Ping; Chen, Ke; Xu, Xiao-Wu; Cai, Jia-Qin; Wu, Di; Zhou, Yu-Cheng

    2014-11-13

    Gastric cancer in remnant stomach is a rare tumor but with poor prognosis. Compared with conventional open surgery, laparoscopic gastrectomy has potential benefits for these patients due to advantages resulting from its minimally invasive approach. Herein, we report on three patients with gastric cancer in remnant stomach who underwent laparoscopic total gastrectomy with intracorporeal esophagojejunostomy successfully. The operative time was 280, 250 and 225 minutes, the estimated blood loss was 100, 80 and 50 ml and the length of postoperative hospital stay was seven, eight and nine days respectively. Our experience has suggested that laparoscopic total gastrectomy with intracorporeal esophagojejunostomy can be a safe, feasible and promising option for patients with gastric cancer in remnant stomach.

  6. Optical pulsations in the Large Magellanic Cloud remnant 0540-69.3

    International Nuclear Information System (INIS)

    Middleditch, J.; Pennypacker, C.

    1985-01-01

    The X-ray pulsar PSR0540-693 was discovered in the Large Magellanic Cloud (LMC) supernova remnant, 0540-69.3, as a pulse, with repetition period approx. 50 ms, in Einstein Observatory data. Previous workers had noted that this remnant resembles the Crab Nebula because of the X-ray power law spectrum and suggested that the nebular emission was synchrotron radiation powered by a central pulsar. After the announcement of X-ray pulsed emission, other workers measured the broad optical band properties of the nebula and found evidence for synchrotron emission; and reported that the 4.5-arc s continuum emission remnant has only a tenth of the luminosity of the Crab Nebula. The authors have now detected pulsed optical emission for the X-ray pulsar, having a time-averaged magnitude of approx. 22.7. (author)

  7. Gravitational waves from remnant massive neutron stars of binary neutron star merger: Viscous hydrodynamics effects

    Science.gov (United States)

    Shibata, Masaru; Kiuchi, Kenta

    2017-06-01

    Employing a simplified version of the Israel-Stewart formalism of general-relativistic shear-viscous hydrodynamics, we explore the evolution of a remnant massive neutron star of binary neutron star merger and pay special attention to the resulting gravitational waveforms. We find that for the plausible values of the so-called viscous alpha parameter of the order 10-2 the degree of the differential rotation in the remnant massive neutron star is significantly reduced in the viscous time scale, ≲5 ms . Associated with this, the degree of nonaxisymmetric deformation is also reduced quickly, and as a consequence, the amplitude of quasiperiodic gravitational waves emitted also decays in the viscous time scale. Our results indicate that for modeling the evolution of the merger remnants of binary neutron stars we would have to take into account magnetohydrodynamics effects, which in nature could provide the viscous effects.

  8. Soft X-ray observations of the supernova remnants HB 3 and 3C 58

    Science.gov (United States)

    Galas, C. M. F.; Tuohy, I. R.; Garmire, G. P.

    1980-01-01

    The HEAO 1 A-2 low energy detectors have discovered soft X-ray emission from a source positionally coincident with the supernova remnant HB 3. The flux in the energy range 0.3-2.2 keV is about 6 x 10 to the -11th ergs per sq cm s. The spectral data are fitted to a hydrogen thermal bremsstrahlung model, and the physical parameters of the supernova remnant are estimated. The age derived is about 21,000 years, and the initial blast energy is about 3.1 x 10 to the 50th ergs. Upper limits to the soft X-ray flux and the luminosity of the supernova remnant 3 C 58 are also derived.

  9. Agricultural intensification exacerbates spillover effects on soil biogeochemistry in adjacent forest remnants.

    Directory of Open Access Journals (Sweden)

    Raphael K Didham

    Full Text Available Land-use intensification is a central element in proposed strategies to address global food security. One rationale for accepting the negative consequences of land-use intensification for farmland biodiversity is that it could 'spare' further expansion of agriculture into remaining natural habitats. However, in many regions of the world the only natural habitats that can be spared are fragments within landscapes dominated by agriculture. Therefore, land-sparing arguments hinge on land-use intensification having low spillover effects into adjacent protected areas, otherwise net conservation gains will diminish with increasing intensification. We test, for the first time, whether the degree of spillover from farmland into adjacent natural habitats scales in magnitude with increasing land-use intensity. We identified a continuous land-use intensity gradient across pastoral farming systems in New Zealand (based on 13 components of farmer input and soil biogeochemistry variables, and measured cumulative off-site spillover effects of fertilisers and livestock on soil biogeochemistry in 21 adjacent forest remnants. Ten of 11 measured soil properties differed significantly between remnants and intact-forest reference sites, for both fenced and unfenced remnants, at both edge and interior. For seven variables, the magnitude of effects scaled significantly with magnitude of surrounding land-use intensity, through complex interactions with fencing and edge effects. In particular, total C, total N, δ15N, total P and heavy-metal contaminants of phosphate fertilizers (Cd and U increased significantly within remnants in response to increasing land-use intensity, and these effects were exacerbated in unfenced relative to fenced remnants. This suggests movement of livestock into surrounding natural habitats is a significant component of agricultural spillover, but pervasive changes in soil biogeochemistry still occur through nutrient spillover channels alone

  10. The influence of massive black hole binaries on the morphology of merger remnants

    Science.gov (United States)

    Bortolas, E.; Gualandris, A.; Dotti, M.; Read, J. I.

    2018-06-01

    Massive black hole (MBH) binaries, formed as a result of galaxy mergers, are expected to harden by dynamical friction and three-body stellar scatterings, until emission of gravitational waves (GWs) leads to their final coalescence. According to recent simulations, MBH binaries can efficiently harden via stellar encounters only when the host geometry is triaxial, even if only modestly, as angular momentum diffusion allows an efficient repopulation of the binary loss cone. In this paper, we carry out a suite of N-body simulations of equal-mass galaxy collisions, varying the initial orbits and density profiles for the merging galaxies and running simulations both with and without central MBHs. We find that the presence of an MBH binary in the remnant makes the system nearly oblate, aligned with the galaxy merger plane, within a radius enclosing 100 MBH masses. We never find binary hosts to be prolate on any scale. The decaying MBHs slightly enhance the tangential anisotropy in the centre of the remnant due to angular momentum injection and the slingshot ejection of stars on nearly radial orbits. This latter effect results in about 1 per cent of the remnant stars being expelled from the galactic nucleus. Finally, we do not find any strong connection between the remnant morphology and the binary hardening rate, which depends only on the inner density slope of the remnant galaxy. Our results suggest that MBH binaries are able to coalesce within a few Gyr, even if the binary is found to partially erase the merger-induced triaxiality from the remnant.

  11. Mergers in galaxy groups. I. Structure and properties of elliptical remnants

    International Nuclear Information System (INIS)

    Taranu, Dan S.; Dubinski, John; Yee, H. K. C.

    2013-01-01

    We present collisionless simulations of dry mergers in groups of 3 to 25 galaxies to test the hypothesis that elliptical galaxies form at the centers of such groups. Mock observations of the central remnants confirm their similarity to ellipticals, despite having no dissipational component. We vary the profile of the original spiral's bulge and find that ellipticals formed from spirals with exponential bulges have too low Sersic indices. Mergers of spirals with de Vaucouleurs (classical) bulges produce remnants with larger Sersic indices correlated with luminosity, as with Sloan Digital Sky Survey ellipticals. Exponential bulge mergers are better fits to faint ellipticals, whereas classical bulge mergers better match luminous ellipticals. Similarly, luminous ellipticals are better reproduced by remnants undergoing many (>5) mergers, and fainter ellipticals by those with fewer mergers. The remnants follow tight size-luminosity and velocity dispersion-luminosity (Faber-Jackson) relations (<0.12 dex scatter), demonstrating that stochastic merging can produce tight scaling relations if the merging galaxies also follow tight scaling relations. The slopes of the size-luminosity and Faber-Jackson relations are close to observations but slightly shallower in the former case. Both relations' intercepts are offset—remnants are too large but have too low dispersions at fixed luminosity. Some remnants show substantial (v/σ > 0.1) rotational support, although most are slow rotators and few are very fast rotators (v/σ > 0.5). These findings contrast with previous studies concluding that dissipation is necessary to produce ellipticals from binary mergers of spirals. Multiple, mostly minor and dry mergers can produce bright ellipticals, whereas significant dissipation could be required to produce faint, rapidly rotating ellipticals.

  12. X-ray emission of the hot gas and of accelerated particles in supernova remnants

    International Nuclear Information System (INIS)

    Acero, F.

    2008-09-01

    The current observations seem to support the theory that the shock wave of supernova remnants accelerate electrons (representing about 1% of cosmic rays) of the interstellar medium up to energies of about 10 15 eV. However there is still no solid evidence that supernova remnants also accelerate protons (major component of cosmic rays). The X-ray observations of those supernova remnants with the satellite XMM-Newton can provide crucial information on the acceleration mechanisms and on this population of accelerated particles. This thesis presents the X-ray analysis of the supernova remnants RX J1713.7-3946 and SN 1006 for which it has been shown that they accelerate electrons efficiently. As a result, these objects are very good targets to compare the theoretical models of acceleration to the observation. For the first object, I constructed through new XMM-Newton observations, the first high-angular resolution mosaic of the entire supernova remnant. I then compared the X- and gamma-ray emission of this object in order to understand the nature of the gamma-ray emission. This spectral and morphological comparison allowed me to discuss the two possible origins of the gamma-ray radiation (issued by electrons or by protons). For SN 1006, I studied the density of the ambient medium in which the shock wave propagates. This density is a key parameter for the hydrodynamical evolution of the remnant and for studying a future gamma-ray emission. The study of X-ray emission of the gas heated by the shock wave allowed me to better estimate of the value of the density so far poorly constrained for this object. (author)

  13. Enveloped virus-like particles as vaccines against pathogenic arboviruses

    NARCIS (Netherlands)

    Pijlman, G.P.

    2015-01-01

    Arthropod-borne arboviruses form a continuous threat to human and animal health, but few arboviral vaccines are currently available. Advances in expression technology for complex, enveloped virus-like particles (eVLPs) create new opportunities to develop potent vaccines against pathogenic

  14. Measuring Eco-efficiency of Production with Data Envelopment Analysis

    NARCIS (Netherlands)

    Kuosmanen, T.K.; Kortelainen, M.

    2005-01-01

    Aggregation of environmental pressures into a single environmental damage index is a major challenge of eco-efficiency measurement. This article examines how the data envelopment analysis (DEA) method can be adapted for this purpose. DEA accounts for substitution possibilities between different

  15. Modeling of heat and mass transfer in lateritic building envelopes

    International Nuclear Information System (INIS)

    Meukam, Pierre

    2004-10-01

    The aim of the present work is to investigate the behavior of building envelopes made of local lateritic soil bricks subjected to different climatic conditions. The analysis is developed for the prediction of the temperature, relative humidity and water content behavior within the walls. The building envelopes studied in this work consist of lateritic soil bricks with incorporation of natural pozzolan or sawdust in order to obtain small thermal conductivity and low-density materials, and limit the heat transfer between the atmospheric climate and the inside environment. In order to describe coupled heat and moisture transfer in wet porous materials, the coupled equations were solved by the introduction of diffusion coefficients. A numerical model HMtrans, developed for prediction of beat and moisture transfer in multi-layered building components, was used to simulate the temperature, water content and relative humidity profiles within the building envelopes. The results allow the prediction of the duration of the exposed building walls to the local weather conditions. They show that for any of three climatic conditions considered, relative humidity and water content do not exceed 87% and 5% respectively. There is therefore minimum possibility of water condensation in the materials studied. The durability of building envelopes made of lateritic soil bricks with incorporation of natural pozzolan or sawdust is not strongly affected by the climatic conditions in tropical and equatorial regions. (author)

  16. Design of a Haptic Feedback System for Flight Envelope Protection

    NARCIS (Netherlands)

    Van Baelen, D.; Ellerbroek, J.; van Paassen, M.M.; Mulder, M.

    2018-01-01

    Current Airbus aircraft use a fly-by-wire control device: a passive spring-damper system which generates, without any force feedback, an electrical signal to the flight control computer. Additionally, a hard flight envelope protection system is used which can limit the inputs of the pilot when

  17. Hygrothermal Simulation: A Tool for Building Envelope Design Analysis

    Science.gov (United States)

    Samuel V. Glass; Anton TenWolde; Samuel L. Zelinka

    2013-01-01

    Is it possible to gauge the risk of moisture problems while designing the building envelope? This article provides a brief introduction to computer-based hygrothermal (heat and moisture) simulation, shows how simulation can be useful as a design tool, and points out a number of im-portant considerations regarding model inputs and limita-tions. Hygrothermal simulation...

  18. Spectral Envelopes and Additive + Residual Analysis/Synthesis

    Science.gov (United States)

    Rodet, Xavier; Schwarz, Diemo

    The subject of this chapter is the estimation, representation, modification, and use of spectral envelopes in the context of sinusoidal-additive-plus-residual analysis/synthesis. A spectral envelope is an amplitude-vs-frequency function, which may be obtained from the envelope of a short-time spectrum (Rodet et al., 1987; Schwarz, 1998). [Precise definitions of such an envelope and short-time spectrum (STS) are given in Section 2.] The additive-plus-residual analysis/synthesis method is based on a representation of signals in terms of a sum of time-varying sinusoids and of a non-sinusoidal residual signal [e.g., see Serra (1989), Laroche et al. (1993), McAulay and Quatieri (1995), and Ding and Qian (1997)]. Many musical sound signals may be described as a combination of a nearly periodic waveform and colored noise. The nearly periodic part of the signal can be viewed as a sum of sinusoidal components, called partials, with time-varying frequency and amplitude. Such sinusoidal components are easily observed on a spectral analysis display (Fig. 5.1) as obtained, for instance, from a discrete Fourier transform.

  19. A model for the sustainable selection of building envelope assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Huedo, Patricia, E-mail: huedo@uji.es [Universitat Jaume I (Spain); Mulet, Elena, E-mail: emulet@uji.es [Universitat Jaume I (Spain); López-Mesa, Belinda, E-mail: belinda@unizar.es [Universidad de Zaragoza (Spain)

    2016-02-15

    The aim of this article is to define an evaluation model for the environmental impacts of building envelopes to support planners in the early phases of materials selection. The model is intended to estimate environmental impacts for different combinations of building envelope assemblies based on scientifically recognised sustainability indicators. These indicators will increase the amount of information that existing catalogues show to support planners in the selection of building assemblies. To define the model, first the environmental indicators were selected based on the specific aims of the intended sustainability assessment. Then, a simplified LCA methodology was developed to estimate the impacts applicable to three types of dwellings considering different envelope assemblies, building orientations and climate zones. This methodology takes into account the manufacturing, installation, maintenance and use phases of the building. Finally, the model was validated and a matrix in Excel was created as implementation of the model. - Highlights: • Method to assess the envelope impacts based on a simplified LCA • To be used at an earlier phase than the existing methods in a simple way. • It assigns a score by means of known sustainability indicators. • It estimates data about the embodied and operating environmental impacts. • It compares the investment costs with the costs of the consumed energy.

  20. CONTROL OF INDOOR ENVIRONMENTS VIA THE REGULATION OF BUILDING ENVELOPES

    Directory of Open Access Journals (Sweden)

    Mitja Košir

    2011-01-01

    Full Text Available The design of comfortable, healthy and stimulating indoor environments in buildings has a direct impact on the users and on energy consumption, as well as on the wider soci-economic environment of society.The indoor environment of buildings is defined with the formulation of the building envelope, which functions as an interface between the internal and external environments and its users. A properly designed, flexible and adequately controlled building envelope is a starting point in the formulation of a high-quality indoor environment. The systematic treatment of the indoor environment and building envelope from a user’s point of view represents an engineering approach that enables the holistic treatment of buildings, as well as integrated components and systems. The presented division of indoor environment in terms of visual, thermal, olfactory, acoustic and ergonomic sub-environments enables the classification and selection of crucial factors influencing design. This selection and classification can be implemented in the design, as well as in control applications of the building envelope. The implementation of the approach described is demonstrated with an example of an automated control system for the internal environment of an office in the building of the Faculty of Civil and Geodetic Engineering.

  1. A model for the sustainable selection of building envelope assemblies

    International Nuclear Information System (INIS)

    Huedo, Patricia; Mulet, Elena; López-Mesa, Belinda

    2016-01-01

    The aim of this article is to define an evaluation model for the environmental impacts of building envelopes to support planners in the early phases of materials selection. The model is intended to estimate environmental impacts for different combinations of building envelope assemblies based on scientifically recognised sustainability indicators. These indicators will increase the amount of information that existing catalogues show to support planners in the selection of building assemblies. To define the model, first the environmental indicators were selected based on the specific aims of the intended sustainability assessment. Then, a simplified LCA methodology was developed to estimate the impacts applicable to three types of dwellings considering different envelope assemblies, building orientations and climate zones. This methodology takes into account the manufacturing, installation, maintenance and use phases of the building. Finally, the model was validated and a matrix in Excel was created as implementation of the model. - Highlights: • Method to assess the envelope impacts based on a simplified LCA • To be used at an earlier phase than the existing methods in a simple way. • It assigns a score by means of known sustainability indicators. • It estimates data about the embodied and operating environmental impacts. • It compares the investment costs with the costs of the consumed energy.

  2. Print and supply of envelopes and file covers

    Indian Academy of Sciences (India)

    “Tender for Supply of Printed Envelopes and File Covers". Tender ... Twenty Five Thousand Only) in the form of Demand Draft drawn on any Nationalized. Bank and .... m) The finalized contract shall be interpreted under Indian Laws. In case of ...

  3. Envelopes of Sets of Measures, Tightness, and Markov Control Processes

    International Nuclear Information System (INIS)

    Gonzalez-Hernandez, J.; Hernandez-Lerma, O.

    1999-01-01

    We introduce upper and lower envelopes for sets of measures on an arbitrary topological space, which are then used to give a tightness criterion. These concepts are applied to show the existence of optimal policies for a class of Markov control processes

  4. Development of a pneumatic roof envelope for industrial greenhouses

    NARCIS (Netherlands)

    Lindner, G.; Vos, de G.J.

    2008-01-01

    The Eindhoven University of Technology (TU/e) was approached by Van Diemen BV, a turn-key greenhouse builder looking for a new and higher insulated design for their green house envelope. They had developed a new system of climate control which rendered windows for ventilation purposes unnecessary

  5. The potential of building envelope greening to achieve quietness

    NARCIS (Netherlands)

    Van Renterghem, T.; Hornikx, M.C.J.; Forssén, J.; Botteldooren, D.

    2013-01-01

    Reduction of noise is one of the multiple benefits of building envelope greening measures. The potential of wall vegetation systems, green roofs, vegetated low screens at roof edges, and also combinations of such treatments, have been studied by means of combining 2D and 3D full-wave numerical

  6. Bioinformatics Analysis of Envelope Glycoprotein E epitopes of ...

    African Journals Online (AJOL)

    The E glycoprotein of dengue virus is responsible for the viral binding to the receptor. The crystal structure of envelope glycoprotein has already been determined. However, where the well-defined Bcell and T-cell epitopes are located is still a question. Because of the large variations among the four dengue genotypes, it is ...

  7. Origin of envelope proteins of a leukemia virus

    International Nuclear Information System (INIS)

    Schneider, R.P.

    1975-01-01

    The roles of avian myeloblastosis virus (AMV) and host myeloblast cells in controlling the protein composition of virus envelope and host cell membrane are being studied by examining an ATPase enzyme in the virus and cells. New culture techniques for virus producing myeloblasts have been developed. (U.S.)

  8. Enveloped virus flocculation and removal in osmolyte solutions.

    Science.gov (United States)

    Gencoglu, Maria F; Heldt, Caryn L

    2015-07-20

    Our ability to reduce infectious disease burden throughout the world has been greatly improved by the creation of vaccines. However, worldwide immunization rates are low. The two most likely reasons are the lack of sufficient distribution in underdeveloped countries and the high cost of vaccine products. The high costs are due to the difficulties of manufacturing individual vaccine products with specialized purification trains. In this study, we propose to use virus flocculation in osmolytes, followed by microfiltration, as an alternative vaccine purification operation. In our previous work, we demonstrated that osmolytes preferentially flocculate a non-enveloped virus, porcine parvovirus (PPV). In this work we show that osmolytes flocculate the enveloped virus, Sindbis virus heat resistant strain (SVHR), and demonstrate a >80% removal with a 0.2 μm microfilter membrane while leaving proteins in solution. The best osmolytes were tested for their ability to flocculate SVHR at different concentrations, pH and ionic strengths. Our best removal was 98% of SVHR in 0.3M mannitol at a pH of 5. We propose that osmolytes are able to flocculate hydrophobic non-enveloped and enveloped virus particles by the reduction of the hydration layer around the particles, which stimulates virus aggregation. Now that we have demonstrated that protecting osmolytes flocculate viruses, this method has the potential to be a future platform purification process for vaccines. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. Spectral Envelope Transformation in Singing Voice for Advanced Pitch Shifting

    Directory of Open Access Journals (Sweden)

    José L. Santacruz

    2016-11-01

    Full Text Available The aim of the present work is to perform a step towards more natural pitch shifting techniques in singing voice for its application in music production and entertainment systems. In this paper, we present an advanced method to achieve natural modifications when applying a pitch shifting process to singing voice by modifying the spectral envelope of the audio excerpt. To this end, an all-pole model has been selected to model the spectral envelope, which is estimated using a constrained non-linear optimization. The analysis of the global variations of the spectral envelope was carried out by identifying changes of the parameters of the model along with the changes of the pitch. With the obtained spectral envelope transformation functions, we applied our pitch shifting scheme to some sustained vowels in order to compare results with the same transformation made by using the Flex Pitch plugin of Logic Pro X and pitch synchronous overlap and add technique (PSOLA. This comparison has been carried out by means of both an objective and a subjective evaluation. The latter was done with a survey open to volunteers on our website.

  10. Masking Release for Sweeping Masker Components with Correlated Envelopes

    DEFF Research Database (Denmark)

    Verhey, Jesko l.; Klein-Hennig, Hendrike; Epp, Bastian

    2013-01-01

    To separate sounds from different sound sources, common properties of natural sounds are used by the auditory system, such as coherent temporal envelope fluctuations and correlated changes of frequency in different frequency regions. The present study investigates how the auditory systemprocesses...

  11. Innovative Danish Building Envelope Components for Passive Houses

    DEFF Research Database (Denmark)

    Tommerup, Henrik M.; Svendsen, Svend

    2006-01-01

    and in some cases very innovative envelope constructions. In this paper, two of the most interesting components are described; a prefabricated light-weight exterior wall element with a load-bearing plywood and steel frame and a foundation / slab on ground solution based on concrete and EPS insulation...

  12. Purification and characterization of cell-envelope proteinase from ...

    African Journals Online (AJOL)

    user

    2012-10-18

    Oct 18, 2012 ... phenylmethylsulfonyl fluoride;. ACE, angiotensin-I-converting enzyme. Poolman, 1998). Cell-envelope proteinase (CEP) play an important role in the lactobacillus proteolytic system. CEPs are the critical enzyme in the system (Kunji et al., 1996), since it is the only enzyme that can initiate the breakdown of.

  13. Geonic black holes and remnants in Eddington-inspired Born-Infeld gravity.

    Science.gov (United States)

    Olmo, Gonzalo J; Rubiera-Garcia, D; Sanchis-Alepuz, Helios

    We show that electrically charged solutions within the Eddington-inspired Born-Infeld theory of gravity replace the central singularity by a wormhole supported by the electric field. As a result, the total energy associated with the electric field is finite and similar to that found in the Born-Infeld electromagnetic theory. When a certain charge-to-mass ratio is satisfied, in the lowest part of the mass and charge spectrum the event horizon disappears, yielding stable remnants. We argue that quantum effects in the matter sector can lower the mass of these remnants from the Planck scale down to the TeV scale.

  14. Onion-shell model for cosmic ray electrons and radio synchrotron emission in supernova remnants

    International Nuclear Information System (INIS)

    Beck, R.; Drury, L.O.; Voelk, H.J.; Bogdan, T.J.

    1985-01-01

    The spectrum of cosmic ray electrons, accelerated in the shock front of a supernova remnant (SNR), is calculated in the test-particle approximation using an onion-shell model. Particle diffusion within the evolving remnant is explicity taken into account. The particle spectrum becomes steeper with increasing radius as well as SNR age. Simple models of the magnetic field distribution allow a prediction of the intensity and spectrum of radio synchrotron emission and their radial variation. The agreement with existing observations is satisfactory in several SNR's but fails in other cases. Radiative cooling may be an important effect, especially in SNR's exploding in a dense interstellar medium

  15. Onion-shell model for cosmic ray electrons and radio synchrotron emission in supernova remnants

    Science.gov (United States)

    Beck, R.; Drury, L. O.; Voelk, H. J.; Bogdan, T. J.

    1985-01-01

    The spectrum of cosmic ray electrons, accelerated in the shock front of a supernova remnant (SNR), is calculated in the test-particle approximation using an onion-shell model. Particle diffusion within the evolving remnant is explicity taken into account. The particle spectrum becomes steeper with increasing radius as well as SNR age. Simple models of the magnetic field distribution allow a prediction of the intensity and spectrum of radio synchrotron emission and their radial variation. The agreement with existing observations is satisfactory in several SNR's but fails in other cases. Radiative cooling may be an important effect, especially in SNR's exploding in a dense interstellar medium.

  16. Nucleosynthesis and remnants in massive stars of solar metallicity

    International Nuclear Information System (INIS)

    Woosley, S.E.; Heger, A.

    2007-01-01

    Hans Bethe contributed in many ways to our understanding of the supernovae that happen in massive stars, but, to this day, a first principles model of how the explosion is energized is lacking. Nevertheless, a quantitative theory of nucleosynthesis is possible. We present a survey of the nucleosynthesis that occurs in 32 stars of solar metallicity in the mass range 12-120M sun . The most recent set of solar abundances, opacities, mass loss rates, and current estimates of nuclear reaction rates are employed. Restrictions on the mass cut and explosion energy of the supernovae based upon nucleosynthesis, measured neutron star masses, and light curves are discussed and applied. The nucleosynthetic results, when integrated over a Salpeter initial mass function (IMF), agree quite well with what is seen in the sun. We discuss in some detail the production of the long lived radioactivities, 26 Al and 60 Fe, and why recent model-based estimates of the ratio 60 Fe/ 26 Al are overly large compared with what satellites have observed. A major source of the discrepancy is the uncertain nuclear cross sections for the creation and destruction of these unstable isotopes

  17. The psychic envelopes in psychoanalytic theories of infancy.

    Directory of Open Access Journals (Sweden)

    Denis eMellier

    2014-07-01

    Full Text Available This paper aims to review the topic of psychic envelopes and to sketch the main outlines of this concept in infancy. We first explore the origins of the concept in Freud's 'protective shield' and then its development in adult psychoanalysis before going on to see how this fits in infancy with post-Bionian psychoanalysis and development. Four central notions guide this review:1 Freud's protective shield describes a barrier to protect the psychic apparatus against potentially overflowing trauma. It is a core notion which highlights a serious clinical challenge for patients for whom the shield is damaged or faulty: the risk of confusion of borders between the internal/external world, conscious/unconscious, mind/body, or self-conservation/sexuality.2 Anzieu's Skin-Ego is defined by the different senses of the body. The different layers of experienced sensation, of this body-ego, go on to form the psychic envelope. This theory contributes to our understanding of how early trauma, due to the failures of maternal care, can continue to have an impact in adult life. 3 Bick's psychic skin establishes the concept in relation to infancy. The mother’s containing functions allow a first psychic skin to develop, which then defines an infant’s psychic space and affords the infant a degree of self-containment. Houzel then conceptualized this process as a stabilization of drive forces.4 Stern's narrative envelope derives from the intersection between psychoanalysis and neuroscience. It gives us another way to conceptualise the development of pre-verbal communication. It may also pave the way for a finer distinction of different types of envelopes.Ultimately, in this review we find that psychic envelopes in infancy can be viewed from four different perspectives (economic, topographical, dynamic and genetic and recommend further investigation.

  18. Confronting Models of Massive Star Evolution and Explosions with Remnant Mass Measurements

    Science.gov (United States)

    Raithel, Carolyn A.; Sukhbold, Tuguldur; Özel, Feryal

    2018-03-01

    The mass distribution of compact objects provides a fossil record that can be studied to uncover information on the late stages of massive star evolution, the supernova explosion mechanism, and the dense matter equation of state. Observations of neutron star masses indicate a bimodal Gaussian distribution, while the observed black hole mass distribution decays exponentially for stellar-mass black holes. We use these observed distributions to directly confront the predictions of stellar evolution models and the neutrino-driven supernova simulations of Sukhbold et al. We find strong agreement between the black hole and low-mass neutron star distributions created by these simulations and the observations. We show that a large fraction of the stellar envelope must be ejected, either during the formation of stellar-mass black holes or prior to the implosion through tidal stripping due to a binary companion, in order to reproduce the observed black hole mass distribution. We also determine the origins of the bimodal peaks of the neutron star mass distribution, finding that the low-mass peak (centered at ∼1.4 M ⊙) originates from progenitors with M ZAMS ≈ 9–18 M ⊙. The simulations fail to reproduce the observed peak of high-mass neutron stars (centered at ∼1.8 M ⊙) and we explore several possible explanations. We argue that the close agreement between the observed and predicted black hole and low-mass neutron star mass distributions provides new, promising evidence that these stellar evolution and explosion models capture the majority of relevant stellar, nuclear, and explosion physics involved in the formation of compact objects.

  19. Uncertainty Analysis of In leakage Test for Pressurized Control Room Envelop

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. B. [KHNP Central Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    In leakage tests for control room envelops(CRE) of newly constructed nuclear power plants are required to prove the control room habitability. Results of the in leakage tests should be analyzed using an uncertainty analysis. Test uncertainty can be an issue if the test results for pressurized CREs show low in leakage. To have a better knowledge of the test uncertainty, a statistical model for the uncertainty analysis is described here and a representative uncertainty analysis of a sample in leakage test is presented. A statistical method for analyzing the uncertainty of the in leakage test is presented here and a representative uncertainty analysis of a sample in leakage test was performed. By using the statistical method we can evaluate the test result with certain level of significance. This method can be more helpful when the difference of the two mean values of the test result is small.

  20. Uncertainty Analysis of In leakage Test for Pressurized Control Room Envelop

    International Nuclear Information System (INIS)

    Lee, J. B.

    2013-01-01

    In leakage tests for control room envelops(CRE) of newly constructed nuclear power plants are required to prove the control room habitability. Results of the in leakage tests should be analyzed using an uncertainty analysis. Test uncertainty can be an issue if the test results for pressurized CREs show low in leakage. To have a better knowledge of the test uncertainty, a statistical model for the uncertainty analysis is described here and a representative uncertainty analysis of a sample in leakage test is presented. A statistical method for analyzing the uncertainty of the in leakage test is presented here and a representative uncertainty analysis of a sample in leakage test was performed. By using the statistical method we can evaluate the test result with certain level of significance. This method can be more helpful when the difference of the two mean values of the test result is small

  1. Quantification of the spatial organization of the nuclear lamina as a tool for cell classification

    NARCIS (Netherlands)

    Righolt, C.H.; Zatreanu, D.A.; Raz, V.

    2013-01-01

    The nuclear lamina is the structural scaffold of the nuclear envelope that plays multiple regulatory roles in chromatin organization and gene expression as well as a structural role in nuclear stability. The lamina proteins, also referred to as lamins, determine nuclear lamina organization and

  2. Early localization of NPA58, a rat nuclear pore-associated protein

    Indian Academy of Sciences (India)

    We have studied the mitotic reassembly of the nuclear envelope, using antibodies to nuclear marker proteins and NPA58 in F-111 rat fibroblast cells. In earlier studies we have proposed that NPA58, a 58 kDa rat nuclear protein, is involved in nuclear protein import. In this report, NPA58 is shown to be localized on the ...

  3. Expansion of the HMX-1 Flight Envelope With the EDU-5/P Laser Eye Protection Spectacles

    National Research Council Canada - National Science Library

    Penhallegon, William

    2004-01-01

    The purpose of this testing was to determine if the day operations envelope should be expanded to include takeoffs and landings, whether the night operations envelope should he expanded in the VH-6ON...

  4. EXOTIC PLANTS IN THE CIBODAS BOTANIC GARDENS REMNANT FOREST: INVENTORY AND CLUSTER ANALYSIS OF SEVERAL ENVIRONMENTAL FACTORS

    Directory of Open Access Journals (Sweden)

    Decky Indrawan Junaedi

    2014-01-01

    Full Text Available Due to potential impact of invasive alien (exotic species to the natural ecosystems, inventory of exotic species in the Cibodas Botanic Gardens (CBG remnant forest area is an urgent need for CBG. Inventory of exotic species can assist gardens manager to set priorities and plan better responses for possible or existed invasive plants in the CBG remnants forest. The objectives of this study are to do inventory of the exotic species in the CBG remnant forest and to determine whether several environmental variables play role to the existence of exotic species in the CBG remnant forests. There are 26 exotic plant species (23 genera, 14 families found and recorded from all four remnant forests in CBG. Cluster analysis of four environmental variables shows that clustering of environmental factors of exotic species correlates with the abundances of those exotic species. The relation between environmental factor clusters and the abundance of those exotics signify the role of environmental variables on the existence of exotic plant species. The information of exotic plant species in the remnants forest is the base information for gardens manager to manage exotic species in CBG remnants forest. The relation of several environmental factors with exotic species abundance could assist gardens manager to understand better the supportive and or suppressor factors of exotics in the CBG remnants forest. Further study on these species is needed to set priorities to decide which species should be treated first in order to minimize the impact of exotic plant species to native ecosystem of CBG.

  5. EXOTIC PLANTS IN THE CIBODAS BOTANIC GARDENS REMNANT FOREST: INVENTORY AND CLUSTER ANALYSIS OF SEVERAL ENVIRONMENTAL FACTORS

    Directory of Open Access Journals (Sweden)

    Decky Indrawan Junaedi

    2014-01-01

    Full Text Available Due to potential impact of invasive alien (exotic species to the natural ecosystems, inventory of exotic species in the Cibodas Botanic Gardens (CBG remnant forest area is an urgent need for CBG. Inventory of exotic species can assist gardens manager to set priorities and plan better responses for possible or existed invasive plants in the CBG remnants forest. The objectives of this study are to do inventory of the exotic species in the CBG remnant forest and to determine whether several environmental variables play role to the existence of exotic species in the CBG remnant forests. There are 26 exotic plant species  (23 genera, 14 families found and recorded from all four remnant forests in CBG. Cluster analysis of four environmental variables shows that clustering of environmental factors of exotic species correlates with the abundances of those exotic species. The relation between environmental factor clusters and the abundance of those exotics signify the role of environmental variables on the existence of exotic plant species. The information of exotic plant species in the remnants forest is the base information for gardens manager to manage exotic species in CBG remnants forest. The relation of several environmental factors with exotic species abundance could assist gardens manager to understand better the supportive and or suppressor factors of exotics in the CBG remnants forest. Further study on these species is needed to set priorities to decide which species should be treated first in order to minimize the impact of exotic plant species to native ecosystem of CBG.

  6. Modeling supernova remnants: effects of diffusive cosmic-ray acceleration on the evolution and application to observations

    NARCIS (Netherlands)

    Kosenko, D.; Blinnikov, S.; Vink, J.

    2011-01-01

    We present numerical models for supernova remnant evolution, using a new version of the hydrodynamical code SUPREMNA. We added a cosmic-ray diffusion equation to the code scheme, employing a two-fluid approximation. We investigate the dynamics of the simulated supernova remnants with different

  7. AM Envelope. The potential of Additive Manufacturing for facade constructions

    Directory of Open Access Journals (Sweden)

    Holger Strauss

    2017-11-01

    Full Text Available This dissertation shows the potential of Additive Manufacturing (AM for the development of building envelopes: AM will change the way of designing facades, how we engineer and produce them. To achieve today’s demands from those future envelopes, we have to find new solutions. New technologies offer one possible way to do so. They open new approaches in designing, producing and processing building construction and facades. Finding the one capable of having big impact is difficult – Additive Manufacturing is one possible answer. The term ‘AM Envelope’ (Additive Manufacturing Envelope describes the transfer of this technology to the building envelope. Additive Fabrication is a building block that aids in developing the building envelope from a mere space enclosure to a dynamic building envelope. First beginnings of AM facade construction show up when dealing with relevant aspects like material consumption, mounting or part’s performance. From those starting points several parts of an existing post-and-beam façade system were optimized, aiming toward the implementation of AM into the production chain. Enhancements on all different levels of production were achieved: storing, producing, mounting and performance. AM offers the opportunity to manufacture facades ‘just in time’. It is no longer necessary to store or produce large numbers of parts in advance. Initial investment for tooling can be avoided, as design improvements can be realized within the dataset of the AM part. AM is based on ‘tool-less’ production, all parts can be further developed with every new generation. Producing tool-less also allows for new shapes and functional parts in small batch sizes – down to batch size one. The parts performance can be re-interpreted based on the demands within the system, not based on the limitations of conventional manufacturing. AM offers new ways of materializing the physical part around its function. It leads toward customized

  8. 78 FR 5148 - Special Conditions: Embraer S.A., Model EMB-550 Airplanes; Flight Envelope Protection: General...

    Science.gov (United States)

    2013-01-24

    ... failure states occur in the electronic flight control system, flight envelope protection features can... Envelope Protection: General Limiting Requirements AGENCY: Federal Aviation Administration (FAA), DOT...), specifically new control architecture and a full digital flight control system which provides flight envelope...

  9. Stability charts for uniform slopes in soils with nonlinear failure envelopes

    OpenAIRE

    Eid, Hisham T.

    2014-01-01

    Based on the results of an extensive parametric study, charts were developed for assessment of the stability of uniform slopes in soils with nonlinear shear strength failure envelopes. The study was conducted using envelopes formed to represent the realistic shapes of soil nonlinear drained strength envelopes and the associated different degrees of nonlinearity. The introduction of a simple methodology to describe the nonlinear envelopes and a stability parameter, the value of which depends o...

  10. Parvoviral nuclear import: bypassing the host nuclear-transport machinery.

    Science.gov (United States)

    Cohen, Sarah; Behzad, Ali R; Carroll, Jeffrey B; Panté, Nelly

    2006-11-01

    The parvovirus Minute virus of mice (MVM) is a small DNA virus that replicates in the nucleus of its host cells. However, very little is known about the mechanisms underlying parvovirus' nuclear import. Recently, it was found that microinjection of MVM into the cytoplasm of Xenopus oocytes causes damage to the nuclear envelope (NE), suggesting that the nuclear-import mechanism of MVM involves disruption of the NE and import through the resulting breaks. Here, fluorescence microscopy and electron microscopy were used to examine the effect of MVM on host-cell nuclear structure during infection of mouse fibroblast cells. It was found that MVM caused dramatic changes in nuclear shape and morphology, alterations of nuclear lamin immunostaining and breaks in the NE of infected cells. Thus, it seems that the unusual nuclear-import mechanism observed in Xenopus oocytes is in fact used by MVM during infection of host cells.

  11. Clinical relevance of non-fasting and postprandial hypertriglyceridemia and remnant cholesterol

    DEFF Research Database (Denmark)

    Nordestgaard, Børge G; Freiberg, Jacob J

    2011-01-01

    Non-fasting triglycerides are measured at any time within up to 8 h (14 h) after any normal meal, while postprandial triglycerides are measured at a fixed time point within up to 8 h (14 h) of a standardised fat tolerance test. The simplest possible way of evaluating remnant cholesterol is non......-fasting/postprandial total cholesterol minus low-density lipoprotein (LDL) cholesterol minus high-density lipoprotein (HDL) cholesterol. Elevated levels of non-fasting/postprandial triglycerides directly correlate with elevated remnant cholesterol. In the general population, 38% of men have non......-fasting/postprandial triglycerides > 2mmol/L (>176 mg/dL) while 45% of men have non-fasting/postprandial triglyceride levels of 1-2 mmol/L (89-176 mg/dL); corresponding fractions in women are 20% and 47%. Also, 31% of men have remnant cholesterol levels > 1mmol/L (>39 mg/dL) while 46% of men have remnant cholesterol levels of 0...

  12. AN X-RAY INVESTIGATION OF THREE SUPERNOVA REMNANTS IN THE LARGE MAGELLANIC CLOUD

    International Nuclear Information System (INIS)

    Klimek, Matthew D.; Points, S. D.; Smith, R. C.; Shelton, R. L.; Williams, R.

    2010-01-01

    We have investigated three supernova remnants (SNRs) in the LMC using multi-wavelength data. These SNRs are generally fainter than the known sample (see Section 4) and may represent a previously missed population. One of our SNRs is the second LMC remnant analyzed which is larger than any Galactic remnant for which a definite size has been established. The analysis of such a large remnant contributes to the understanding of the population of highly evolved SNRs. We have obtained X-ray images and spectra of three of these recently identified SNRs using the XMM-Newton observatory. These data, in conjunction with pre-existing optical emission-line images and spectra, were used to determine the physical conditions of the optical- and X-ray-emitting gas in the SNRs. We have compared the morphologies of the SNRs in the different wavebands. The physical properties of the warm ionized shell were determined from the Hα surface brightness and the SNR expansion velocity. The X-ray spectra were fit with a thermal plasma model and the physical conditions of the hot gas were derived from the model fits. Finally, we have compared our observations with simulations of SNR evolution.

  13. Vocal cord paralysis following I-131 ablation of a postthyroidectomy remnant

    International Nuclear Information System (INIS)

    Lee, T.C.; Harbert, J.C.; Dejter, S.W.; Mariner, D.R.; VanDam, J.

    1985-01-01

    Vocal cord paralysis has been reported following I-131 therapy of thyrotoxicosis and following ablation of the whole thryoid. However, this rare complication has not previously been described following I-131 ablation of a postthyroidectomy remnant. The authors report a patient who required tracheostomy for bilateral vocal cord paralysis following I-131 ablation after near-total thyroidectomy for papillary thyroid carcinoma

  14. Case Report: CT diagnosis of thymic remnant cyst/thymopharyngeal duct cyst

    International Nuclear Information System (INIS)

    Daga, Bipin V; Chaudhary, VA; Dhamangaokar, VB

    2009-01-01

    A 4-year-old boy presented with history of left anterolateral neck swelling since birth. He was clinically diagnosed to have a branchial cleft cyst. A CT scan revealed findings suggestive of a thymic remnant cyst. The lesion was excised and the diagnosis was confirmed by histopathology

  15. Gamma-ray bursts from stellar remnants - Probing the universe at high redshift

    NARCIS (Netherlands)

    Wijers, R.A.M.J.; Bloom, J.S.; Bagla, J.S.; Natarajan, P.

    1998-01-01

    A gamma-ray burst (GRB) releases an amount of energy similar to that of a supernova explosion, which combined with its rapid variability suggests an origin related to neutron stars or black holes. Since these compact stellar remnants form from the most massive stars not long after their birth, GRBs

  16. HIGH RESOLUTION 36 GHz IMAGING OF THE SUPERNOVA REMNANT OF SN 1987A

    International Nuclear Information System (INIS)

    Potter, T. M.; Staveley-Smith, L.; Zanardo, G.; Ng, C.-Y.; Gaensler, B. M.; Ball, Lewis; Kesteven, M. J.; Manchester, R. N.; Tzioumis, A. K.

    2009-01-01

    The aftermath of supernova (SN) 1987A continues to provide spectacular insights into the interaction between an SN blastwave and its circumstellar environment. We here present 36 GHz observations from the Australia Telescope Compact Array of the radio remnant of SN 1987A. These new images, taken in 2008 April and 2008 October, substantially extend the frequency range of an ongoing monitoring and imaging program conducted between 1.4 and 20 GHz. Our 36.2 GHz images have a diffraction-limited angular resolution of 0.''3-0.''4, which covers the gap between high resolution, low dynamic range VLBI images of the remnant and low resolution, high dynamic range images at frequencies between 1 and 20 GHz. The radio morphology of the remnant at 36 GHz is an elliptical ring with enhanced emission on the eastern and western sides, similar to that seen previously at lower frequencies. Model fits to the data in the Fourier domain show that the emitting region is consistent with a thick inclined torus of mean radius 0.''85, and a 2008 October flux density of 27 ± 6 mJy at 36.2 GHz. The spectral index for the remnant at this epoch, determined between 1.4 GHz and 36.2 GHz, is α = -0.83. There is tentative evidence for an unresolved central source with flatter spectral index.

  17. Numerical Simulations of Supernova Remnant Evolution in a Cloudy Interstellar Medium

    Energy Technology Data Exchange (ETDEWEB)

    Slavin, Jonathan D.; Smith, Randall K.; Foster, Adam; Winter, Henry D.; Raymond, John C.; Slane, Patrick O. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Yamaguchi, Hiroya, E-mail: jslavin@cfa.harvard.edu [NASA Goddard Space Flight Center, Code 662, Greenbelt, MD 20771 (United States)

    2017-09-01

    The mixed morphology class of supernova remnants has centrally peaked X-ray emission along with a shell-like morphology in radio emission. White and Long proposed that these remnants are evolving in a cloudy medium wherein the clouds are evaporated via thermal conduction once being overrun by the expanding shock. Their analytical model made detailed predictions regarding temperature, density, and emission profiles as well as shock evolution. We present numerical hydrodynamical models in 2D and 3D including thermal conduction, testing the White and Long model and presenting results for the evolution and emission from remnants evolving in a cloudy medium. We find that, while certain general results of the White and Long model hold, such as the way the remnants expand and the flattening of the X-ray surface brightness distribution, in detail there are substantial differences. In particular we find that the X-ray luminosity is dominated by emission from shocked cloud gas early on, leading to a bright peak, which then declines and flattens as evaporation becomes more important. In addition, the effects of thermal conduction on the intercloud gas, which is not included in the White and Long model, are important and lead to further flattening of the X-ray brightness profile as well as lower X-ray emission temperatures.

  18. X-ray emission from reverse-shocked ejecta in supernova remnants

    Science.gov (United States)

    Cioffi, Denis F.; Mckee, Christopher F.

    1990-01-01

    A simple physical model of the dynamics of a young supernova remnant is used to derive a straightforward kinematical description of the reverse shock. With suitable approximations, formulae can then be developed to give the X-ray emission of the reverse-shocked ejecta. The results are found to agree favorably with observations of SN1006.

  19. Use of radionuclide techniques for assessment of splenic function and detection of splenic remnants

    International Nuclear Information System (INIS)

    Ganguly, S.; Sinha, S.; Sarkar, B.R.; Basu, S.; Ghosh, S.

    1998-01-01

    Full text: The spleen is often involved in hematological malignancies; it is also the site of RBC destruction in thalassemia and ITP. In latter cases, splenectomy is often performed and postoperatively, detection of functioning splenic remnants affect the prognosis adversely. In this study, we assessed the usefulness of radionuclide techniques in : a) assessment of splenic function in primarily non-splenic diseases (benign or malignant), and b) detection of splenic remnant after splenectomy. 12 patients of splenomegaly and 5 patients after splenectomy underwent splenic imaging; imaging was performed using both 99m Tc-sulphur colloid (with first pass) and 99m Tc labelled heat denatured RBCs as tracers. Thus splenic perfusion, morphology and RBC trapping functions were all assessed. The colloid images usually matched the RBC images except in 2 cases where photogenic areas (presumably infarcts) were visualized on RBC scans that were missed on colloid scans. Three of the post splenectomy cases revealed functioning splenic remnants, which was also better visualized on RBC scans. It is concluded that radionuclide imaging could be used regularly for assessing function of spleen, or detecting splenic remnants

  20. Clinical outcomes of endoscopic submucosal dissection for early gastric cancer in remnant stomach or gastric tube.

    Science.gov (United States)

    Nishide, N; Ono, H; Kakushima, N; Takizawa, K; Tanaka, M; Matsubayashi, H; Yamaguchi, Y

    2012-06-01

    Little information exists regarding the optimal treatment of early gastric cancer (EGC) in a remnant stomach or gastric tube. The aim of this study was to assess the feasibility and clinical outcomes of endoscopic submucosal dissection (ESD) for EGC in a remnant stomach and gastric tube. Between September 2002 and December 2009, ESD was performed in 62 lesions in 59 patients with EGC in a remnant stomach (48 lesions) or gastric tube (14 lesions). Clinicopathological data were retrieved retrospectively to assess the en bloc resection rate, complications, and outcomes. Treatment results were assessed according to the indications for endoscopic resection, and were compared with those of ESD performed in a whole stomach during the same study period. The en bloc resection rates for lesions within the standard and expanded indication were 100 % and 93 %, respectively. Postoperative bleeding occurred in five patients (8 %). The perforation rate was significantly higher (18 %, 11 /62) than that of ESD in a whole stomach (5 %, 69 /1479). Among the perforation cases, eight lesions involved the anastomotic site or stump line, and ulcerative changes were observed in five lesions. The 3-year overall survival rate was 85 %, with eight deaths due to other causes and no deaths from gastric cancer. A high en bloc resection rate was achieved by ESD for EGC in a remnant stomach or gastric tube; however, this procedure is still technically demanding due to the high complication rate of perforation. © Georg Thieme Verlag KG Stuttgart · New York.