WorldWideScience

Sample records for nucleaire asn autorise

  1. ASN annual report 2004

    International Nuclear Information System (INIS)

    2005-01-01

    The Nuclear Safety Authority (ASN) groups the Directorate General for Nuclear Safety and Radiation Protection (DGSNR), reporting to the Ministries for Health, Environment and Industry, and the devolved services of the State on which it relies for nuclear safety and radiation protection supervision, primarily DRIRE, DRASS and DDASS. The main topic of 2004, discussed in this report are: nuclear Safety and Transparency bill, shaping the new ASN, setting up inspection of non-BNI nuclear activities, Radiation protection and monitoring of patients, the safety of the EPR reactor project, the national plan for radioactive waste management, the future of high-level long-lived waste, harmonizing nuclear safety in Europe and ASN international involvement. (A.L.B.)

  2. French regulations in the nuclear field and standards related to nuclear pressure equipment; Reglementation francaise dans le domaine nucleaire et normes relatives aux equipements sous pression nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Mourlon, S.; Limousin, S.; Van Hoecke, J.C. [Autorite de surete nucleaire 6, place du Colonel Bourgoin 75012 Paris (France)

    2007-07-01

    French regulations on nuclear pressure equipment have been updated with the December 12, 2005 Order related to Nuclear Pressure Equipment, so-called 'ESPN Order'. This Order is at the junction of regulations covering safety on the one hand and pressure equipment on the other hand. As regards manufacturing, the ESPN Order extends to nuclear pressure equipment the approach and essential requirements of the European Pressure Equipment Directive (PED - transposed in France by the December 13, 1999 Decree) while adding specific nuclear and radiation safety requirements. For in-service inspection, it sets additional provisions to those of the December 13, 1999 Decree so that the nuclear and radiation safety requirements applying in nuclear facilities are also taken into account for those equipment. The specific case of PWR main primary and secondary systems is covered by the November 10, 1999 Order. The ESPN Order leaves a major part to industrial codes and standards. Its publication makes it necessary to check that the codes used for nuclear pressure equipment comply with the new requirements and may induce modifications of the codes. Furthermore, as the market for operators of nuclear facilities and manufacturers of mechanical equipment is becoming global, these evolutions should be considered in a worldwide context. Last, the Nuclear Transparency and Security Act of June 13, 2006 - which created the Nuclear safety authority (ASN) with competence over nuclear and radiation safety, covering specifically nuclear pressure equipment - will induce further amendments of regulations. (authors) [French] La reglementation francaise en matiere d equipements sous pression nucleaires a ete refondee avec la parution de l arrete du 12 decembre 2005 relatif aux equipements sous pression nucleaires, dit 'arrete ESPN'. Ce texte se situe a l intersection des reglementations en matiere de surete, d une part, et d equipements sous pression, d autre part. En matiere de

  3. External PCR, ASN's decision

    International Nuclear Information System (INIS)

    Anon.

    2012-01-01

    The French law imposes in some situations the presence of a person skilled in radiation protection (PCR). This article describes the cases when this person must belong to the staff of the enterprise or when this person may be sub-contracted. For instance in most nuclear facilities the PCR must be on the payroll, for enterprises dedicated to nuclear transport the PCR's job can be sub-contracted. A decision given by the ASN (French Nuclear Safety Authority) sets the minimal requests (in terms of training, job contract, activities) of the sub-contracted PCR. (A.C.)

  4. ASN 2009 annual report

    International Nuclear Information System (INIS)

    2010-01-01

    After a presentation of the roles, missions and organization of the ASN (the French Nuclear safety Authority), this document presents and reports its actions in various domains: ionizing radiations and health and environmental risks (knowledge on these risks and hazards, nuclear activities controlled by the ASN, surveillance of exposures to ionizing radiations), principles and actors of nuclear safety, radioprotection and environment protection control, regulation (general framework, proximity nuclear regulation, nuclear installation legal regime, radioactive material transport regulation, arrangements associated with some risks and some specific activities), control of nuclear activities and exposures to ionizing radiations, situations of radiological emergency, public information, international relationships (objectives in Europe and in the world, relationships within the EU and multilateral relationships, bilateral relationships, international convention, international conferences), regional overview of nuclear safety and radioprotection, medical and non medical uses of ionizing radiations, transport of radioactive materials, EDF nuclear plants, nuclear fuel cycle installations, nuclear research installations and other installations, basic nuclear installation dismantling safety, radioactive wastes and polluted sites. This report also provides presentations of incident and accident classification scales and law texts

  5. ASN annual report 2004; ASN Rapport annuel 2004

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    The Nuclear Safety Authority (ASN) groups the Directorate General for Nuclear Safety and Radiation Protection (DGSNR), reporting to the Ministries for Health, Environment and Industry, and the devolved services of the State on which it relies for nuclear safety and radiation protection supervision, primarily DRIRE, DRASS and DDASS. The main topic of 2004, discussed in this report are: nuclear Safety and Transparency bill, shaping the new ASN, setting up inspection of non-BNI nuclear activities, Radiation protection and monitoring of patients, the safety of the EPR reactor project, the national plan for radioactive waste management, the future of high-level long-lived waste, harmonizing nuclear safety in Europe and ASN international involvement. (A.L.B.)

  6. The French Nuclear Safety Authority - ASN

    International Nuclear Information System (INIS)

    2013-01-01

    The ASN (Nuclear Safety Authority) was created by the act of 13 June 2006 concerning the transparency and safety of nuclear activities. The ASN is an independent administrative body that is in charge of controlling nuclear activities in France. The ASN has a workforce of 471 people and a budget of about 76 millions euros. This article details its missions and how it is organized to cover all the French territory. (A.C.)

  7. The French Nuclear Safety Authority (ASN)

    International Nuclear Information System (INIS)

    Alloso, Ph.

    2011-01-01

    This article presents the statutes, the organization and the missions of the Nuclear Safety Authority (ASN) whose scope includes radiation protection since 2002. Globally ASN is in charge of: -) participating to the making of laws and regulations, -) delivering administrative authorizations, -) controlling the conformity of nuclear installations and activities with the laws and regulations, -) informing the public, and -) reporting on the state of nuclear safety and radiation protection each year. (A.C.)

  8. Synthesis of the report from the IRRS evaluation mission performed at the ASN in April 2009 by 12 international experts under the IAEA coordination

    International Nuclear Information System (INIS)

    2009-01-01

    At the request of the Government authorities of France, an international team of 24 experts visited the Autorite de Surete Nucleaire (ASN), the French regulatory authority for nuclear and radiation safety, in November 2006 to conduct the first full scope Integrated Regulatory Review Service (IRRS) mission. The purpose of the mission was to undertake a peer review of the regulatory body of France against the IAEA Safety Standards and to exchange information and experience on safety regulation. In March 2008 the Government authorities of France requested a follow-up mission to review the measures undertaken following the recommendations and suggestions presented in the report of the November 2006 IRRS mission. The scope of the IRRS follow-up mission covered the regulatory aspects of the facilities and practices regulated by ASN, nuclear power plants, research reactors, fuel cycle facilities, medical practices with further review of radiotherapy, industrial and research activities, waste facilities, decommissioning, remediation, public information and communication and, in addition, it was also extended to cover the application of the Code of Conduct of Safety and Security of Radioactive Sources. The review was conducted from March 29 to April 3 2009 by an IRRS team consisting of 12 senior regulatory experts from 11 Member States, two staff members from the IAEA, one IAEA observer and an IAEA administrative assistant. During the review the team recognized that ASN has taken a number of initiatives to improve its effectiveness and efficiency and that ASN faces new challenges. ASN supplied a package of documentation and a well prepared self-assessment, in advance of the mission, including a status report and an action plan to improve its regulatory effectiveness. Both regulatory technical and policy issues were addressed. The policy issues discussed were: regulatory independence, the relationship between ASN and IRSN and medical issues. The IRRS follow-up mission

  9. Asn12 and Asn278: Critical Residues for In Vitro Biological Activity of Reteplase

    Directory of Open Access Journals (Sweden)

    Naganath Mandi

    2010-01-01

    Full Text Available Reteplase (rPA is a thrombolytic agent used for the treatment of acute myocardial infarction. We studied the expression of rPA and its selected asparagine mutants after integration into the Pichia genome. Though methanol induction of the native and the rPA mutants showed similar expression levels (~200–250 mg/L, the mutants displayed significant loss of protease activity. Strikingly, the clot lysis activities of these mutants were considerably different. While mutation of Asn12 (N12P of the Kringle 2 domain showed delayed clot lysis activity (1/2=38 min compared to the native rPA (1/2=33 min, a faster rate of clot lysis (1/2=27 min was observed when the Asn278 (N278S of the serine protease domain was mutated. Interestingly, the slowest clot lysis activity (1/2=49 min demonstrated by the double mutant (N12P, N278S suggests the dominant role of Asn12 in regulating the fibrinolytic activity of rPA. The results presented in this paper indicate that the fibrinolytic and the proteolytic activities of rPA are independent of each other.

  10. La Spectroscopie laser appliquee a la physique nucleaire

    CERN Document Server

    Le Blanc, F

    2001-01-01

    l'etude de la forme du noyau atomique est un sujet fondamental puisqu'elle constitue un excellent laboratoire pour tester et valider les differents modeles nucleaires.La spectroscopie atomique et plus particulierement la spectroscopie laser est un moyen precis et inhabituel pour caracteriser des observables liees a la forme du noyau.

  11. Siloette, Siloe mock-up; Siloette, modele nucleaire de siloe

    Energy Technology Data Exchange (ETDEWEB)

    Delcroix, V.; Jeanne, G.; Mitault, G.; Schulhof, P. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1964-07-01

    Siloette is the Siloe mock-up. The main installations are described: various tanks, building, auxiliaries, control systems... Precis ions are given about precautions taken for using spent fuel elements. (authors) [French] Siloette est le modele nucleaire de SILOE. On decrit ses diverses installations: bassins, batiments, auxiliaires, controle... Des precisions sont donnees sur les precautions prises pour y utiliser des elements uses. (auteurs)

  12. Zweifache Stichprobenpruefplaene fuer Qualitative und Quantitative Markmale mit Minimaler Maximaler ASN (Double Sample Plans for Qualitative and Quantitative Features with Minimal Maximal Average Sample Number (ASN))

    National Research Council Canada - National Science Library

    Mueller, Kai

    1998-01-01

    ... with minimal maximal Average Sampler Number (ASN) in chapter three. Chapter four features single and double variable sample plans and, as expected, chapter five provides the determination of these plans with minimal maximal ASN...

  13. ASN annual report 2007 - ASN report abstracts on the state of Nuclear Safety and Radiation Protection in France in 2007; ASN rapport annuel 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    The 2007 annual report of the French nuclear safety authority (ASN) presents the highlights of the year in the domain of nuclear safety and radiation protection in France. The year 2007 was marked by the implementation of a new legislative and regulatory framework created by the 13 June 2006 Act on transparency and security in the nuclear field (TSN) and the 28 June Act on the sustainable management of radioactive materials and wastes. As in the previous two years, the year was relatively satisfactory from the nuclear safety viewpoint and slightly less so with regard to small-scale nuclear activities. For two years now, the medical field has been marked by the declaration to ASN of a number of serious radiotherapy accidents which have led to several deaths or the need for extensive surgery. The following main topics are reviewed in the document: 1 - the decrees implementing the 'TSN' act and the 'Waste' act; 2 - the new ASN, one year on; 3 - ASN regulatory actions in the field of radiotherapy; 4 - regulation of new installations; 5 - the key issues for regulation of existing installations; 6 - nuclear safety and radiation protection research; 7 - policy for management of the post-accident phase of a radiological emergency; 8 - sites and soils polluted by radioactive materials; 9 - international harmonization of nuclear safety and radiation protection.

  14. ASN report abstracts on the state of Nuclear Safety and Radiation Protection in France in 2008. ASN annual report 2008

    International Nuclear Information System (INIS)

    2009-01-01

    ASN is an independent administrative authority tasked, on behalf of the state, with regulating nuclear safety and radiation protection in order to protect workers, patients and the environment from the hazards involved in nuclear activities. It also contributes to informing the public. ASN, run by a five-member commission, regulates the whole of the sector, acting in a completely impartial manner. The ASN Commission presents its report on the state of nuclear safety and radiation protection in France in 2008. Contents: A - Introduction: The year 2008. B - Key topics: 1. ASN actions to promote greater transparency; 2. EDF nuclear power plant ageing and operating life: the conditions for continued operation; 3. The prevention of malicious acts; 4. ASN regulation of the radiotherapy sector; 5. Regulating and monitoring the construction of the Flamanville 3 EPR reactor; 6. ASN's international nuclear safety responsibilities; 7. The new nuclear countries; 8. Decommissioning of basic nuclear installations and the low-level, long-lived waste disposal project. C - Overview: 1 - Nuclear activities: ionising radiations and health risks; 2 - Principles and stakeholders in the regulation of nuclear safety and radiation protection; 3 - Regulation; 4 - Regulation of nuclear activities and exposure to ionising radiations; 5 - Environmental protection; 6 - Public information and transparency; 7 - International relations; 8 - Radiological emergencies; 9 - Medical uses of ionising radiations; 10 - Industrial and research activities; 11 - Transport of radioactive materials; 12 - EDF nuclear power plants; 13 - Nuclear fuel cycle installations; 14 - Nuclear research facilities and various nuclear installations; 15 - Safe decommissioning of basic nuclear installations; 16 - Radioactive waste and polluted sites. D - Appendices: List of basic nuclear installations; ASN decisions and opinions published in 2008 in its Official Bulletin; Acronyms, abbreviations and names

  15. A.S.N. regulation of Flamanville 3 EPR construction

    International Nuclear Information System (INIS)

    Limousin, S.

    2009-01-01

    The EPR authorization decree for Flamanville 3 was issued by the French government (decree no. 2007-534) on the 10 April 2007. The construction activities are going on in the manufacturer workshops and at Flamanville site. The decree published in November 2007, and related to the so called TSN law (the nuclear transparency and safety nuclear law published in 2006), specifies that the commissioning licence (the agreement for first fuel load) has to be granted by an ASN decision on the basis of the assessment of the demonstration of the plant safety. In this aim, one part of ASN's work is to review, with its technical sup-port organisation (IRSN), the reactor construction in order to appreciate the safety level of the construction activities. This paper describes ASN's strategy for the regulation of Flamanville 3 EPR construction activities, endorsed by ASN commission at the end of November 2007, and the main events which have occurred on Flamanville site since the beginning of the construction. The article presents the main ASN conclusions of this regulation at this time. (author)

  16. Knockdown of asparagine synthetase (ASNS) suppresses cell proliferation and inhibits tumor growth in gastric cancer cells.

    Science.gov (United States)

    Yu, Qingxiang; Wang, Xiaoyu; Wang, Li; Zheng, Jia; Wang, Jiang; Wang, Bangmao

    2016-10-01

    Asparagine synthetase (ASNS) gene encodes an enzyme that catalyzes the glutamine- and ATP-dependent conversion of aspartic acid to asparagine. ASNS is deemed as a promising therapeutic target and its expression is associated with the chemotherapy resistance in several human cancers. However, its role in gastric cancer tumorigenesis has not been investigated. In this study, we employed small interfering RNA (siRNA) to transiently knockdown ASNS in two gastric cancer cell lines, AGS and MKN-45, followed by growth rate assay and colony formation assay. Dose response curve analysis was performed in AGS and MKN-45 cells with stable ASNS knockdown to assess sensitivity to cisplatin. Xenograft experiment was performed to examine in vivo synergistic effects of ASNS depletion and cisplatin on tumor growth. Expression level of ASNS was evaluated in human patient samples using quantitative PCR. Kaplan-Meier curve analysis was performed to evaluate association between ASNS expression and patient survival. Transient knockdown of ASNS inhibited cell proliferation and colony formation in AGS and MKN-45 cells. Stable knockdown of ASNS conferred sensitivity to cisplatin in these cells. Depletion of ASNS and cisplatin treatment exerted synergistic effects on tumor growth in AGS xenografts. Moreover, ASNS was found to be up-regulated in human gastric cancer tissues compared with matched normal colon tissues. Low expression of ASNS was significantly associated with better survival in gastric cancer patients. ASNS may contribute to gastric cancer tumorigenesis and may represent a novel therapeutic target for prevention or intervention of gastric cancer.

  17. Publication of the inspection follow-up letters of the ASN on its site web asn.gouv.fr

    International Nuclear Information System (INIS)

    2002-01-01

    Since February 2002, the French authority of nuclear safety (ASN) publishes on its web site (http://www.asn.gouv.fr) the letters addressed to the operators of nuclear facilities at the end of its inspections. The ASN carries out about 700 inspections every year which concern the French nuclear facilities, the central services of nuclear operators or of their suppliers, and the transports of nuclear materials. Each inspection is followed by a follow-up letter which mentions all anomalies noticed during the inspection and eventually asks for some remedial actions or for some complements of information. This document brings together the letters published between february and May 2002 and concerning the on-site inspections of nuclear facilities (EdF nuclear power plants, CEA centers, Cogema facilities, other sites) and the off-site inspections (Andra, transports of nuclear materials). (J.S.)

  18. ASN annual report 2007 - ASN report abstracts on the state of Nuclear Safety and Radiation Protection in France in 2007

    International Nuclear Information System (INIS)

    2008-01-01

    The 2007 annual report of the French nuclear safety authority (ASN) presents the highlights of the year in the domain of nuclear safety and radiation protection in France. The year 2007 was marked by the implementation of a new legislative and regulatory framework created by the 13 June 2006 Act on transparency and security in the nuclear field (TSN) and the 28 June Act on the sustainable management of radioactive materials and wastes. As in the previous two years, the year was relatively satisfactory from the nuclear safety viewpoint and slightly less so with regard to small-scale nuclear activities. For two years now, the medical field has been marked by the declaration to ASN of a number of serious radiotherapy accidents which have led to several deaths or the need for extensive surgery. The following main topics are reviewed in the document: 1 - the decrees implementing the 'TSN' act and the 'Waste' act; 2 - the new ASN, one year on; 3 - ASN regulatory actions in the field of radiotherapy; 4 - regulation of new installations; 5 - the key issues for regulation of existing installations; 6 - nuclear safety and radiation protection research; 7 - policy for management of the post-accident phase of a radiological emergency; 8 - sites and soils polluted by radioactive materials; 9 - international harmonization of nuclear safety and radiation protection

  19. Assessment of ASN inspections apart from BNI (Greater South West)

    International Nuclear Information System (INIS)

    Menechal, Ph.

    2008-01-01

    After having recalled recent evolutions of the ASN's organization (the French nuclear safety authority) and its basic missions (regulation elaboration, decisions, control of nuclear activities and installations, public information), the author presents the Bordeaux ASN's department which is in charge of the south-western part of France. He indicates and comments some data illustrating the performed actions and missions. He describes the objectives and procedures of inspection which may depend on the activity (external radiotherapy, interventional radiology, research laboratories). He assesses theses inspections in terms of radioprotection organization, of risk assessment and of definition of regulated areas, of personnel classification and dosimetric follow-on, of training of exposed personnel, of medical follow-on, of radioprotection control, of training of patients to radioprotection, of source management, and of waste and effluent management

  20. The control of nuclear sector; Le controle du nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The Asn is loaded with the control of the nuclear safety and the radiation protection in France: it provides this control, in the name of the state, to protect the workers, the patients, the public and the environment of the risks in relation with nuclear activities. The control is the core business of Asn. Asn so checks the nuclear basic installations (I.N.B.), since their conception until their dismantling, the pressure equipment specially conceived for these installations, the management of the radioactive waste as well as the transport of radioactive substances. Asn also checks all the industrial and research installations as well as the hospitals where are used ionizing radiations. It is a more recent profession there, because dating the reform of the control of the nuclear power of 2002, which constitutes that of the radiation protection. The first responsibility of the activities at risks falls to the one who begins them. This principle applies to all the sectors checked by Asn: an industrialist is responsible for the safety of the nuclear installations which he exploits, a doctor is responsible for the use of the ionizing radiations which he uses. (N.C.)

  1. The Bacillus subtilis and Bacillus halodurans Aspartyl-tRNA Synthetases Retain Recognition of tRNA(Asn).

    Science.gov (United States)

    Nair, Nilendra; Raff, Hannah; Islam, Mohammed Tarek; Feen, Melanie; Garofalo, Denise M; Sheppard, Kelly

    2016-02-13

    Synthesis of asparaginyl-tRNA (Asn-tRNA(Asn)) in bacteria can be formed either by directly ligating Asn to tRNA(Asn) using an asparaginyl-tRNA synthetase (AsnRS) or by synthesizing Asn on the tRNA. In the latter two-step indirect pathway, a non-discriminating aspartyl-tRNA synthetase (ND-AspRS) attaches Asp to tRNA(Asn) and the amidotransferase GatCAB transamidates the Asp to Asn on the tRNA. GatCAB can be similarly used for Gln-tRNA(Gln) formation. Most bacteria are predicted to use only one route for Asn-tRNA(Asn) formation. Given that Bacillus halodurans and Bacillus subtilis encode AsnRS for Asn-tRNA(Asn) formation and Asn synthetases to synthesize Asn and GatCAB for Gln-tRNA(Gln) synthesis, their AspRS enzymes were thought to be specific for tRNA(Asp). However, we demonstrate that the AspRSs are non-discriminating and can be used with GatCAB to synthesize Asn. The results explain why B. subtilis with its Asn synthetase genes knocked out is still an Asn prototroph. Our phylogenetic analysis suggests that this may be common among Firmicutes and 30% of all bacteria. In addition, the phylogeny revealed that discrimination toward tRNA(Asp) by AspRS has evolved independently multiple times. The retention of the indirect pathway in B. subtilis and B. halodurans likely reflects the ancient link between Asn biosynthesis and its use in translation that enabled Asn to be added to the genetic code. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  2. Renewal of release and sampling authorizations of the Cattenom nuclear power plant. Complementary note on the authorizations demands of radioactive release; Renouvellement des autorisations de rejets et de prelevements de la centrale nucleaire de Cattenom. Note complementaire sur les demandes d'autorisation de rejets radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Marignac, Y.; Coeytaux, X

    2003-10-15

    The present note follows the exchanges with the contracting authority, the Cattenom nuclear power plant, during the public hearing stood on the 10. of october 2003 at Cattenom. In the frame of the evaluation of the inquiry file by WISE -Paris, this note constitutes a deepening on the question of authorization demands for the radioactive releases. The elements supplied by E.D.F in the file submitted to the inquiry, and the presentation of these demands and the information complements brought during the meeting of the 10. of october, raise different problems of evaluation and justification relative to the evolution of radioactive release of Cattenom. The note analyses in particular, the increasing of dosimetry impact expected from the progression of real release forecasted by the operator, and the weight linked to the feedback of clad failure problem. It discusses the justification brought by E.D.F. to the standing and even the increasing of liquid tritium release instead of the expected reduction, facing the arguments of the operator to the experience feedback on the park and to the uncertainties on the future progress. (N.C.)

  3. Construire son Propre Rapport à l’Autorité Enseignante en s’Engageant dans un Processus d’Autorisation de Soi

    OpenAIRE

    Robbes, Bruno

    2017-01-01

    Partant des impasses de l’autorité naturelle dans la relation d’enseignement, cet article approfondit la dimension « avoir de l’autorité » qui concerne la part de subjectivité que chaque professeur engage dans cette relation. En se plaçant du point de vue d’un sujet enseignant qui construit son propre rapport à l’autorité en s’engageant dans un processus d’autorisation de soi, l’auteur observe le travail de la subjectivité à l’œuvre dans la relation d’enseignement traversée par la problématiq...

  4. Treatment of effluent at the Saclay Centre d'Etudes Nucleaires (1960); Le traitement des effluents du Centre d'Etudes Nucleaires de Saclay (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Wormser, G. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    The Centre d'Etudes Nucleaires at Saclay possesses several installations from which liquid radioactive effluent is rejected, and it has thus been found necessary to construct a station for the purification of radioactive liquids and to settle various chemical, analytical and technological problems. This report describes, in the following order: - the disposal possibilities at the Centre d'Etudes Nucleaires, Saclay, - the effluents produced at the centre, - the set-up for collecting effluent, - treatment of the effluent, - results of these treatments. (author) [French] La presence, au Centre d'Etudes Nucleaires de Saclay, de plusieurs installations susceptibles de rejeter des effluents liquides radioactifs a necessite la construction d'une station d'epuration d'eaux radioactives et la mise au point de differents problemes chimiques, analytiques et technologiques. Dans ce rapport, nous exposerons successivement: - les possibilites de rejet du Centre d'Etudes Nucleaires de Saclay, - les effluents du centre, - le dispositif de collecte des effluents, - le traitement de ces effluents, - les resultats de ces traitements. (auteur)

  5. Enhancing Nephrology Career Interest through the ASN Kidney TREKS Program.

    Science.gov (United States)

    Maursetter, Laura J; Stern, Lauren D; Sozio, Stephen M; Patel, Ankit B; Rao, Reena; Shah, Hitesh H; Leight, Katlyn; Okusa, Mark D; Zeidel, Mark L; Parker, Mark G

    2016-06-01

    The Kidney Tutored Research and Education for Kidney Students (TREKS) Program is a product of the American Society of Nephrology (ASN) Workforce Committee that seeks to connect medical and graduate students to nephrology. This program starts with a weeklong camp-like course introducing participants to renal physiology through classic and modern experiments. Next, each student is matched with a nephrology mentor at his or her home institution to foster a better understanding of a nephrology career. Lastly, the students are encouraged to participate in scholarly activities and attend the ASN Kidney Week. Now in its third year, with a total of 84 participants, survey data suggest early success of the program, with a self-reported 40% increased interest in nephrology fellowship and/or research careers. In addition, students give high ratings to the course components and mentorship pairings. Continued student tracking will be necessary to determine the long-term program effect. Copyright © 2016 by the American Society of Nephrology.

  6. Radiotoxicity, dose and nuclear alchemy; Radiotoxiciteit, dosis en nucleaire alchemie

    Energy Technology Data Exchange (ETDEWEB)

    Schram, R. [Nuclear Research and Consultancy Group NRG, Petten (Netherlands)

    2006-07-01

    An outline is given of the nuclear fuel cycle and related products, focusing on the radiotoxicity and radioactive waste dose. Also, it is explained how those subjects form the basis of research on transmutation and recycling of radioactive waste. Finally, attention will be paid to nuclear alchemy, i.e. the steps to be taken for transmutation and recycling, based on current developments in research at NRG. [Dutch] In dit artikel zal een toelichting worden gegeven op de splijtstofcyclus en de producten die daarbij vrijkomen. Hierbij zal worden ingegaan op de radiotoxiciteit en dosis van het radioactief anal. Tevens zal worden uitgelegd hoe deze begrippen de basis vormen voor keuzes binnen het onderzoek naar transmutatie en recycling van radioactief afval. Ook zal de nucleaire alchemie, de benodigde stappen voor transmutatie en recycling, worden behandeld aan de hand van de actuele ontwikkelingen in het onderzoek zoals onder meer uitgevoerd bij NRG.

  7. Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family

    NARCIS (Netherlands)

    Thaw, P.; Sedelnikova, S.E.; Muranova, T.; Wiese, S.; Ayora, S.; Alonso, J.C.; Brinkman, A.B.; Akerboom, A.P.; Oost, van der J.; Rafferty, J.B.

    2006-01-01

    The Lrp/AsnC family of transcriptional regulatory proteins is found in both archaea and bacteria. Members of the family influence cellular metabolism in both a global (Lrp) and specific (AsnC) manner, often in response to exogenous amino acid effectors. In the present study we have determined both

  8. ASN report on nuclear safety and radioprotection status in France in 2010

    International Nuclear Information System (INIS)

    2011-01-01

    After a general overview of the activity of the ASN (the French nuclear safety authority), of its missions and organisation, this activity report indicates the main events of 2010 concerning the actions performed by the ASN and the activities controlled by the ASN. These both aspects are then detailed. The actions performed by the ASN are dealing with nuclear activities (ionizing radiations and risks for health and for the environment), principles and actors of nuclear safety control, radioprotection and environment protection, regulation, control of nuclear activities and exposures to ionizing radiations, emergency situations, public information, international relationship, regional overview of nuclear safety and radioprotection. The activities controlled by the ASN are the medical uses of ionizing radiations, their non medical uses, the transport of radioactive materials, electronuclear plants, installations related to nuclear fuel cycle, nuclear research installations and other nuclear installations, the safety of nuclear installation dismantling, radioactive wastes and polluted sites

  9. Treatment of effluent at the Saclay Centre d'Etudes Nucleaires (1960)

    International Nuclear Information System (INIS)

    Wormser, G.

    1960-01-01

    The Centre d'Etudes Nucleaires at Saclay possesses several installations from which liquid radioactive effluent is rejected, and it has thus been found necessary to construct a station for the purification of radioactive liquids and to settle various chemical, analytical and technological problems. This report describes, in the following order: - the disposal possibilities at the Centre d'Etudes Nucleaires, Saclay, - the effluents produced at the centre, - the set-up for collecting effluent, - treatment of the effluent, - results of these treatments. (author) [fr

  10. Effects of Asn318 and Asp87Asn318 mutations on signal transduction by the gonadotropin-releasing hormone receptor and receptor regulation.

    Science.gov (United States)

    Awara, W M; Guo, C H; Conn, P M

    1996-02-01

    GnRH receptor (GnRH-R) contains Asn87 and Asp318 instead of the more frequently observed Asp87 and Asn318 found in other G protein-coupled receptors. In the present study, site-directed mutagenesis was used to introduce Asn318 and Asp87Asn318 into GnRH-R. The effect on coupling and regulation of GnRH-R was studied by stable expression of wild and mutant mouse GnRH-R in the lactotropic GH3 cells; these normally release PRL in response to TRH stimulation. The responses to Buserelin (a metabolically stable GnRH analog) in three different cell lines, M1, N8, and ND1 (expressing wild-type, Asn318 mutant, and Asp87Asn318 mutant mouse GnRH-R, respectively) were compared with that observed in the previously characterized GGH3-1' cells, which stably express rat GnRH-R. The Asn318 and Asp87Asn318 mutations had no measurable effect on ligand binding, but abolished the initial down-regulation of receptor that was observed in M1 and GGH3-1' cells, suggesting that the normal location of Asn87 and Asp318 in GnRH-R is involved in the regulation of GnRH-R. In N8 and ND1 cells, Buserelin-stimulated inositol phosphate (IP) production was attenuated, but the release of both cAMP and PRL was stimulated in a dose- and time-dependent manner. These mutations apparently impaired the coupling between GnRH-R and G proteins involved in IP production, but not those involved in cAMP release. In M1 cells, Buserelin stimulation produced a significant increase in IP production, but neither cAMP nor PRL release was significantly stimulated. These findings are consistent with the previous suggestion that GnRH-stimulated PRL release is mediated by a cAMP second messenger system in transfected GGH3 cells.

  11. The control of base nuclear installations; Le controle des installations nucleaires de base (INB)

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2009-04-15

    The Authority of Nuclear Safety ( A.S.N). presents in this column the current events of the control of the nuclear base installations during november, december 2008 and january 2009, classified by nuclear site. This information is also available in real-time on the A.S.N. web site, www.asn.fr, in the column 'news'. We can consult all the notices of significant incident published as well as the following letters of inspection, the notices of information about the reactors shutdown, press releases and the A.S.N. information notes. (N.C.)

  12. ASN report of the status of nuclear safety and radiation protection in France in 2012

    International Nuclear Information System (INIS)

    Chevet, Pierre-Franck; Delmestre, Alain; Bardet, Marie-Christine; Covard, Fabienne; Landrin, Sophie

    2013-01-01

    After a presentation of the French Nuclear Safety Authority (ASN), its missions, some key figures illustrating its activities and its organisation, this report proposes an overview of marking events and of actions undertaken by the ASN after the Fukushima accident. Then, the report proposes a detailed and commented overview of actions undertaken by the ASN in different fields and domains: nuclear activities, principles and actors of nuclear safety and radiation protection control, regulation, control of nuclear activities and of exposures to ionizing radiations, radiological and post-accidental emergency situations, public information and transparency, international relationships, regional overview of nuclear safety and radiation protection. The last part addresses activities controlled by the ASN: medical use of ionizing radiations, industrial, research and veterinary uses and source safety, transport of radioactive materials, electronuclear plants, installations related to nuclear fuel cycle, nuclear research and other nuclear installations, safety of dismantling of base nuclear installations, radioactive wastes and polluted sites

  13. Structural investigations of the active-site mutant Asn156Ala of outer membrane phospholipase A: Function of the Asn-His interaction in the catalytic triad

    NARCIS (Netherlands)

    Snijder, H.J.; van Eerde, J.H.; Kalk, K.H.; Dekker, N.; Egmond, M.R.; Dijkstra, B.W.

    2010-01-01

    Outer membrane phospholipase A (OMPLA) from Escherichia coli is an integral-membrane enzyme with a unique His-Ser-Asn catalytic triad. In serine proteases and serine esterases usually an Asp occurs in the catalytic triad; its role has been the subject of much debate. Here the role of the uncharged

  14. N-Glycosylation analysis of yeast Carboxypeptidase Y reveals the ultimate removal of phosphate from glycans at Asn368.

    Science.gov (United States)

    B S, Gnanesh Kumar; Surolia, Avadhesha

    2017-05-01

    Carboxypeptidase Y from Saccharomyces cerivisiae was characterized for its site specific N-glycosylation through mass spectrometry. The N-glycopeptides were derived using non specific proteases and are analysed directly on liquid chromatography coupled to ion trap mass spectrometer in tandem mode. The evaluation of glycan fragment ions and the Y 1 ions (peptide+HexNAc) +n revealed the glycan sequence and the corresponding site of attachment. We observed the microheterogeneity in N-glycans such as Man 11-15 GlcNAc 2 at Asn 13 , Man 8-12 GlcNAc 2 at Asn 87 , Man 9-14 GlcNAc 2 at Asn 168 and phosphorylated Man 12-17 GlcNAc 2 as well as Man 11-16 GlcNAc 2 at Asn 368 . The presence of N-glycans with Man <18 GlcNAc 2 indicated that in vacuoles the steady release of mannose/phospho mannose residues from glycans occurs initially at Asn 13 or Asn 168 followed by at Asn 368 . However, glycans at Asn 87 which comprises Man 8-12 residues as reported earlier remain intact suggesting its inaccessibility for a similar processing. This in turn indicates the interaction of the glycan at Asn 87 with the polypeptide chain implicating it in the folding of the protein. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. How a regulator is preparing for reviewing a license application file: The case of ASN

    International Nuclear Information System (INIS)

    Tanguy, Loic

    2014-01-01

    The French Nuclear Safety Authority (ASN) is an independent administrative authority. It prepares regulation pertaining to the management of radioactive waste, monitors the control of safety of basic nuclear installations that produce or treat waste or are involved in their disposal and performs inspections of waste producers (EDF, AREVA, CEA, hospitals, research centres, etc.) and Andra, the French National Radioactive Waste Management Agency. It regulates the overall system set up by Andra for accepting waste from producers and assesses waste management policy and the practices of radioactive waste producers. It reviews license applications and authorises commissioning of nuclear installations. In order to review technical documents, ASN benefits from the expertise of technical support organisations. The French Institute for Radiation Protection and Nuclear Safety (IRSN) is the main such organisation. ASN has been making efforts to diversify its experts for several years. In preparing its decisions, ASN also calls on the opinions and recommendations of seven Advisory Committees of Experts (GPE), with expert knowledge in the areas of waste, nuclear pressure equipment, medical exposure, non-medical radiation protection, reactors, transport, and laboratories and nuclear plants. ASN consults the GPEs in preparing its main decisions. In particular, they review the preliminary, provisional and final safety analysis reports for each nuclear installation. They can also be consulted about changes in regulations or doctrine. (authors)

  16. Nuclear program of Iran. Towards de-escalation of a nuclear crisis. Advisory letter; Nucleair programma van Iran. Naar de-escalatie van een nucleaire crisis. Briefadvies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-04-15

    The Dutch government, partly at the request of the House of Representatives (Second Chamber), the AIV asked to give an opinion about the position of Iran in the region and the role of the nuclear program of Iran in the geopolitical relations, in view of the most recent developments [Dutch] De Nederlandse regering heeft, mede op verzoek van de Tweede Kamer der Staten-Generaal, de AIV gevraagd advies uit te brengen over de positie van Iran in de regio en de rol van het nucleaire programma van Iran in de geopolitieke verhoudingen hierin, mede gelet op de meest recente ontwikkelingen.

  17. ASN report on the status of nuclear safety and radiation protection in France in 2015. Extracts

    International Nuclear Information System (INIS)

    2016-01-01

    After a recall of ASN missions, key figures and organisation, an overview of main events for 2015, and a presentation of the French law related to energy transition for a green growth, a first part of this huge document presents actions undertaken by the ASN in 2015 in different fields: ionizing radiations and risks for health and the environment, principles and actors of control of nuclear safety and radiation protection, regulation, control of nuclear activities and of exposures to ionizing radiations, emergency radiological and post-accidental situations, public information transparency and participation, international relationships, regional overview of nuclear safety and radiation protection. The second part addresses activities controlled by the ASN: medical uses of ionizing radiations, industrial, research and veterinary uses and source safety, transportation of radioactive materials, EDF nuclear power plants, installations related to nuclear fuel cycle, various industrial and research installations, safety of basic nuclear installation dismantling, radioactive wastes and polluted sites and soils

  18. Publication of the inspection follow-up letters of the ASN on its site web asn.gouv.fr; Publication des lettres de suite d'inspection de l'ASN sur son site web asn.gouv.fr

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    Since February 2002, the French authority of nuclear safety (ASN) publishes on its web site (http://www.asn.gouv.fr) the letters addressed to the operators of nuclear facilities at the end of its inspections. The ASN carries out about 700 inspections every year which concern the French nuclear facilities, the central services of nuclear operators or of their suppliers, and the transports of nuclear materials. Each inspection is followed by a follow-up letter which mentions all anomalies noticed during the inspection and eventually asks for some remedial actions or for some complements of information. This document brings together the letters published between february and May 2002 and concerning the on-site inspections of nuclear facilities (EdF nuclear power plants, CEA centers, Cogema facilities, other sites) and the off-site inspections (Andra, transports of nuclear materials). (J.S.)

  19. Management of long-lived radioactive waste: stakes and ASN actions; La gestion des dechets radioactifs a vie longue: enjeux et actions de l'ASN

    Energy Technology Data Exchange (ETDEWEB)

    Dandrieux, G. [Autorite de Surete Nucleaire, Dir. des dechets, des installations de recherche et du cycle, Division de Marseille, 75 - Paris (France)

    2011-02-15

    Due to the length of time it takes to decay, long-lived radioactive waste will remain a hazard on a timescale beyond the length of a human life, and even of several generations. In the case of this waste, long-term management solutions must be implemented to protect human health and the environment without requiring human intervention. In accordance with requirements under the Law, ANDRA (national agency for the management of radioactive waste) is carrying out research on disposal solutions in deep or subsurface geological formations. Nonetheless, until such repositories become available, ASN (authority for nuclear safety) has a duty to ensure safety at current and future interim storage facilities, as well as the safety of operations to retrieve and package this type of waste. To this end, ASN acts on several levels: it is involved in drawing up regulations and reference texts, at national and international level, it examines safety analysis reports related to radioactive waste management at basic nuclear installations, by means of inspections that it performs at every step in radioactive waste management. In its capacity as joint coordinator of the national plan for the management of nuclear waste and materials (PNGMDR) working group, ASN also plays a very active role in drawing up the provisions of the PNGMDR aimed at improving and optimising radioactive waste management. (author)

  20. Solid state chemistry of new polysulphides in A/Sn/S (A = Na, K, Rb ...

    Indian Academy of Sciences (India)

    Administrator

    Solid state chemistry of new polysulphides in A/Sn/S (A = Na, K,. Rb) systems. M SUSEELA DEVI and K VIDYASAGAR. Department of Chemistry, Indian Institute of Technology Madras,. Chennai 600 036, India. Ternary polychalcogenides containing chalocogen–chalcogen bonds are metastable compounds that have been ...

  1. Conserved water-mediated H-bonding dynamics of catalytic Asn ...

    Indian Academy of Sciences (India)

    Prakash

    [Nandi T K, Bairagya H R, Mukhopadhyay B P, Sekar K, Sukul D and Bera A K 2009 Conserved water-mediated H-bonding dynamics of catalytic. Asn 175 in plant thiol protease; J. Biosci. 34 27–34]. Keywords. Conserved water in molecular recognition; MD simulation; plant cysteine protease. Abbreviations used: CHASA ...

  2. The control of base nuclear facilities (I.N.B.); Le controle des installations nucleaires de base (INB)

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2009-02-15

    The Authority of Nuclear Safety ( A.S.N). presents in this column the current events of the control of the nuclear basic installations during august, september, october 2008, classified by nuclear site. This information is also available in real-time on the A.S.N. web site, www.asn.fr, in the column 'news'. We can consult all the notices of significant incident published as well as the following letters of inspection, the notices of information about the reactors shutdown, press releases and the A.S.N. information notes. (N.C.)

  3. ASN report on the status of nuclear safety and radiation protection in France in 2011

    International Nuclear Information System (INIS)

    2012-01-01

    The first part of this huge report proposes a detailed overview of ASN activities in different fields: ionizing radiations related to nuclear activities and risks for health and the environment, principles and actors of nuclear safety control, of radiation protection and of protection of the environment, regulation, control of nuclear activities and exposures to ionizing radiations, emergency situations, public information and transparency, international relationships, regional overview of nuclear safety and radiation protection. The second part addresses the activities controlled by the ASN: medical use of ionizing radiations, non medical use of ionizing radiations, transport of radioactive materials, electronuclear power stations, facilities involved in the nuclear fuel cycle, research facilities and other nuclear installations, the safety of dismantling of nuclear base installations, radioactive wastes and polluted sites and soils

  4. [Structure and photoluminescence of ASnO3 (A = Ca, Sr and Ba) : Eu nanocrystalline].

    Science.gov (United States)

    Fu, Xiao-Yan; Niu, Shu-Yun; Zhang, Hong-Wu; Xin, Qin

    2007-09-01

    The present paper reports the photoluminescence properties of nanocrytalline ASnO3 (A = Ca, Sr and Ba) : 1% Eu phosphor synthesized by the Pechini-type sol-gel method. The powder was characterized by X-ray diffraction (XRD), UV-Vis absorption spectra, transmission electron microscopy (TEM) and photoluminescence measurements. The experimental results show that BaSnO3 has the ideal cubic peroskite structure, while SrSnO3 and CaSnO3 are both distorted from cubic symmetry by an octahedral tilting distortion. The difference of structure in induced the different spectral properties of ASnO3 : 1% Eu. On the other hand, when A2+ changes from Ca2+ to Ba2+, the luminescence intensity becomes weak. So CaSnO3 : 1% Eu seems to be a good candidate for new phosphors.

  5. Scanning Tunneling Microscopy study and unusual transport properties of the topological semimetal a-Sn

    Science.gov (United States)

    Ruan, Jiawei

    Weyl semimetals are new states of quantum matter with topological Weyl nodes near Fermi level in the bulk and Fermi arcs at the surface, which are paid a lot attention in recently years. Here#¬we report another topological semimetal a-Sn., which is double Weyl semimetal in the magnetic field and Dirac semimetal in an appropriate in-plane strain. By combing Landau level spectroscopy and quasiparticle interference, we obtain the linear dispersion near the Dirac point within strain while quadratic band dispersion near Γpoint without strain. We also observe the negative longitudinal magnetoresistance (LMR) in both two system, which is caused by chiral anomaly. However ,the LMR profiles of strained a-Sn have a little rise and then descend while the unstrained one drop directly, which is due to the different type of Weyl semimetal and further confirm our prediction.

  6. The 'Asx-Pro turn' as a local structural motif stabilized by alternative patterns of hydrogen bonds and a consensus-derived model of the sequence Asn-Pro-Asn.

    Science.gov (United States)

    Wilson, D R; Finlay, B B

    1997-05-01

    Analyses of databases derived from the Brookhaven Protein Data Bank have identified a set of related turn structures formed by the sequence Asx-Pro-Xxx(n). In a variety of flanking structural contexts, more than 60% of Asx-Pro sequences adopt a turn conformation stabilized by a set of alternative hydrogen bonds among the side chain O delta and backbone C = O carbonyl oxygens of Asx (residue i) and the backbone NH of residues i + 2, i + 3 and in some cases i + 4. In contrast, the structures adopted by Ser-Pro, His-Pro and other Xxx-Pro sequences reflect more heterogeneous hydrogen-bonding patterns. As expected, structures formed by Asx-Pro-Asx are similar to those formed by Asx-Pro-Xxx(n), but in some cases additional hydrogen bonds are formed between the Asx side chains. Hydrogen bond patterns within Asx-Pro and Asn-Pro-Asn turns are consistent with published NMR studies of helical (Asn-Pro-Asn-Ala)n peptides, indicating that a consensus structure reflecting these hydrogen bonds can serve as a partial model of the Asn-Pro-Asn-Ala tetrapeptide repeats of Plasmodium falciparum circumsporozoite protein.

  7. ASN1-encoded asparagine synthetase in floral organs contributes to nitrogen filling in Arabidopsis seeds.

    Science.gov (United States)

    Gaufichon, Laure; Marmagne, Anne; Belcram, Katia; Yoneyama, Tadakatsu; Sakakibara, Yukiko; Hase, Toshiharu; Grandjean, Olivier; Clément, Gilles; Citerne, Sylvie; Boutet-Mercey, Stéphanie; Masclaux-Daubresse, Céline; Chardon, Fabien; Soulay, Fabienne; Xu, Xiaole; Trassaert, Marion; Shakiebaei, Maryam; Najihi, Amina; Suzuki, Akira

    2017-08-01

    Despite a general view that asparagine synthetase generates asparagine as an amino acid for long-distance transport of nitrogen to sink organs, its role in nitrogen metabolic pathways in floral organs during seed nitrogen filling has remained undefined. We demonstrate that the onset of pollination in Arabidopsis induces selected genes for asparagine metabolism, namely ASN1 (At3g47340), GLN2 (At5g35630), GLU1 (At5g04140), AapAT2 (At5g19950), ASPGA1 (At5g08100) and ASPGB1 (At3g16150), particularly at the ovule stage (stage 0), accompanied by enhanced asparagine synthetase protein, asparagine and total amino acids. Immunolocalization confined asparagine synthetase to the vascular cells of the silique cell wall and septum, but also to the outer and inner seed integuments, demonstrating the post-phloem transport of asparagine in these cells to developing embryos. In the asn1 mutant, aberrant embryo cell divisions in upper suspensor cell layers from globular to heart stages assign a role for nitrogen in differentiating embryos within the ovary. Induction of asparagine metabolic genes by light/dark and nitrate supports fine shifts of nitrogen metabolic pathways. In transgenic Arabidopsis expressing promoter Ca MV 35S ::ASN1 fusion, marked metabolomics changes at stage 0, including a several-fold increase in free asparagine, are correlated to enhanced seed nitrogen. However, specific promoter Napin2S ::ASN1 expression during seed formation and a six-fold increase in asparagine toward the desiccation stage result in wild-type seed nitrogen, underlining that delayed accumulation of asparagine impairs the timing of its use by releasing amide and amino nitrogen. Transcript and metabolite profiles in floral organs match the carbon and nitrogen partitioning to generate energy via the tricarboxylic acid cycle, GABA shunt and phosphorylated serine synthetic pathway. © 2017 The Authors The Plant Journal © 2017 John Wiley & Sons Ltd.

  8. Management of long-lived radioactive waste: stakes and ASN actions

    International Nuclear Information System (INIS)

    Dandrieux, G.

    2011-01-01

    Due to the length of time it takes to decay, long-lived radioactive waste will remain a hazard on a timescale beyond the length of a human life, and even of several generations. In the case of this waste, long-term management solutions must be implemented to protect human health and the environment without requiring human intervention. In accordance with requirements under the Law, ANDRA (national agency for the management of radioactive waste) is carrying out research on disposal solutions in deep or subsurface geological formations. Nonetheless, until such repositories become available, ASN (authority for nuclear safety) has a duty to ensure safety at current and future interim storage facilities, as well as the safety of operations to retrieve and package this type of waste. To this end, ASN acts on several levels: it is involved in drawing up regulations and reference texts, at national and international level, it examines safety analysis reports related to radioactive waste management at basic nuclear installations, by means of inspections that it performs at every step in radioactive waste management. In its capacity as joint coordinator of the national plan for the management of nuclear waste and materials (PNGMDR) working group, ASN also plays a very active role in drawing up the provisions of the PNGMDR aimed at improving and optimising radioactive waste management. (author)

  9. The protein C omega-loop substitution Asn2Ile is associated with reduced protein C anticoagulant activity.

    LENUS (Irish Health Repository)

    Preston, Roger J S

    2012-02-01

    We report a kindred with heritable protein C (PC) deficiency in which two siblings with severe thrombosis showed a composite type I and IIb PC deficiency phenotype, identified using commercial PC assays (proband: PC antigen 42 u\\/dl, amidolytic activity 40 u\\/dl, anticoagulant activity 9 u\\/dl). The independent PROC nucleotide variations c.669C>A (predictive of Ser181Arg) and c.131C>T (predictive of Asn2Ile) segregated with the type I and type IIb PC deficiency phenotypes respectively, but co-segregated in the siblings with severe thrombosis. Soluble thrombomodulin (sTM)-mediated inhibition of plasma thrombin generation from an individual with PC-Asn2Ile was lower (endogenous thrombin potential (ETP) 56 +\\/- 1% that of ETP determined without sTM) than control plasma (ETP 15 +\\/- 2%) indicating reduced PC anticoagulant activity. Recombinant APC-Asn2Ile exhibited normal amidolytic activity but impaired anticoagulant activity. Protein S (PS)-dependent anticoagulant activity of recombinant APC-Asn2Ile and binding of recombinant APC-Asn2Ile to endothelial protein C receptor (EPCR) were reduced compared to recombinant wild-type APC. Asn2 lies within the omega-loop of the PC\\/APC Gla domain and this region is critical for calcium-induced folding and subsequent interactions with anionic phospholipids, EPCR and PS. The disruption of these interactions in this naturally-occurring PC variant highlights their collective importance in mediating APC anticoagulant activity in vivo.

  10. Analytic index for nuclear physicians uses; Repertoire analytique a l'usage des physiciens nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Ballini, R.; Barloutaud, R.; Bernas, R.; Bretonneau, P.; Chaminade, R.; Cohen, R.; Conjeaud, M.; Cotton, E.; Faraggi, H.; Grjebine, T.; Joffre, H.; Laboulaye, H. de; Lesueur, C.; Leveque, A.; Moreau, J.; Naggiar, V.; Papineau, L.; Prugne, P.; Schuhl, C.; Studinowski, FJ.; Netter, F.; Raievski, V.; Valladas, G. [Commissariat a l' Energie Atomique, Lab. du Fort de Chatillon, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires; Marty, N.; Renard, G. [College de France, Lab. de Chimie Nucleaire (France)

    The problem of the documentation in nuclear physics becomes constantly more complex. Every week brings its share of new publications, always more numerous and more varied. To remedy to this facts that we tried, in the service of Nuclear Physics of the CEA, to give to the documentation a character of a collective and systematized work. The present report covers the literature appeared between first January 1950 and first July 1951. (Volume 1: CEA report number 120; Volume 2: CEA report number 184). (M.B.) [French] Le probleme de la documentation en physique nucleaire devient sans cesse plus complexe. Chaque semaine apporte son lot de publications, toujours plus nombreuses et plus diversifiees. C'est pour essayer de porter remede a cet etat de choses que nous avons essaye, au service de Physique Nucleaire du C.E.A., de donner a la documentation le caractere d'un travail collectif systematise. Le present rapport couvre la litterature parue entre le premier Janvier 1950 et le premier Juillet 1951. (Tome 1: Rapport CEA numero 120; Tome 2: Rapport CEA numero 184). (M.B.)

  11. The formation of scientists and technicians at the 'Centre d'Etudes Nucleaires' at Saclay

    International Nuclear Information System (INIS)

    Debiesse, J.

    1958-01-01

    The considerable needs in research workers and scientists which are asked by the nuclear energy obliged the Commissariat a l'Energie atomique to deal with a particular effort to increase the quantitative and qualitative formation of scientists. Most various ways have been used. 1- A National Institute of Nuclear Sciences and Nuclear Techniques was created, by a joint decree of the Prime Minister and the Minister for National Education (june 18, 1957). This Institute of Higher Teaching (250 students) indulges in the following matters: atomic engineering, quantum mechanics, theory and technic of particle accelerators, special metallurgy, radiobiology, thermic and mechanics of fluids. 2- An associated centre of the 'Conservatoire National des Arts et Metiers' was created (200 students) for technical assistants, drawers, etc. 3- In contribution with both electronic industry and Ministry of Work, the Centre d'Etudes Nucleaires contributes to an accelerated formation of technical assistants into Professional Centres. Conclusion: Training of scientists and research workers is one of the most important activities of the Centre d'Etudes Nucleaires de Saclay. Without losing its technical efficiency, it has supplied and varied means adapted to the various purposes that we shall reach. (author) [fr

  12. Nuclear biological studies in France; Les etudes de biologie nucleaires en France

    Energy Technology Data Exchange (ETDEWEB)

    Coursaget, J. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1961-07-01

    On the occasion of a colloquium on radiobiological research programmes, a number of documents dealing with French accomplishments and projects in this field were collected together. We felt that it would be useful to assemble these papers in one report; although they are brief and leave gaps to be filled in, they provide certain data, give an overall view of the situation, and can also suggest a rough plan for the general policy to adopt in the field of 'nuclear' biological research; i.e. research based on the nuclear tracer method or devoted to the action of ionising radiations. (author) [French] Un colloque sur les programmes de recherche en radiobiologie nous a donne l'occasion de reunir des documents sur les realisations et les projets francais dans ce domaine. Il nous a semble utile de reunir en un rapport l'ensemble de ces documents, qui, malgre leur brievete et malgre les lacunes qu'ils comportent, donnent un certain nombre d'informations, permettent une vue d'ensemble et peuvent dessiner aussi l'ebauche d'une politique coherente en matiere de recherches biologiques 'nucleaires', c'est-a-dire de recherches basees sur la methode des indicateurs nucleaires ou consacrees a l'action des rayonnements ionisants. (auteur)

  13. The formal notices of the French authority of nuclear safety; Les mises en demeure de l'autorite de surete nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    The French authority of nuclear safety (ASN) publishes on its web site (http://www.asn.gouv.fr) the formal notices and official statements addressed by the ASN to the concerned responsible persons (operators of nuclear facilities, directors of companies etc..) when anomalies requiring a corrective action have been noticed during on-site or off-site safety inspections. This document brings together the formal notices addressed by the ASN since June 2000 and up to April 2002. (J.S.)

  14. Isolation of L-3-phenyllactyl-Leu-Arg-Asn-NH2 (Antho-RNamide), a sea anemone neuropeptide containing an unusual amino-terminal blocking group

    DEFF Research Database (Denmark)

    Grimmelikhuijzen, C J; Rinehart, K L; Jacob, E

    1990-01-01

    Using a radioimmunoassay for the carboxyl-terminal sequence Arg-Asn-NH2, we have purified a peptide from acetic acid extracts of the sea anemone Anthopleura elegantissima. By classical amino acid analyses, mass spectrometry, and 1H NMR spectroscopy, the structure of this peptide was determined as 3......-phenyllactyl-Leu-Arg-Asn-NH2. By using reversed-phase HPLC and a chiral mobile phase, it was shown that the 3-phenyllactyl group had the L configuration. Immunocytochemical staining with antiserum against Arg-Asn-NH2 showed that L-3-phenyllactyl-Leu-Arg-Asn-NH2 (Antho-RNamide) was localized in neurons of sea...

  15. Assessment of patient radiation protection in external radiotherapy departments after inspections performed by the ASN 2008

    International Nuclear Information System (INIS)

    Franchi, Vincent; Marchal, Carole

    2009-10-01

    This report proposes an assessment of patient radiation protection in external radiotherapy. It is based on inter-regional syntheses of inspections performed by the ASN in external radiotherapy departments during 2008. It addresses 6 main themes related to patient radiation protection: human and material resources, organisation of medical physics, training in patient radiation protection, mastering of equipment (maintenance, internal quality controls of medical devices), safety and care quality management (formalization of the patient care process and definition of responsibilities, patient identity control, treatment preparation, and treatment execution), and risk management (a priori risk analysis, declaration, recording and internal processing of dysfunctions, improvements of care quality and safety management system)

  16. Changes in FGFR2 amino-acid residue Asn549 lead to Crouzon and Pfeiffer syndrome with hydrocephalus

    Directory of Open Access Journals (Sweden)

    Caroline Apra

    2016-10-01

    Full Text Available Mutations in Fibroblast Growth Factor Receptor II (FGFR2 have been identified in patients with Crouzon and Pfeiffer syndrome, among which rare mutations of the intracellular tyrosine kinase domain. Correlating subtle phenotypes with each rare mutation is still in progress. In Necker-Enfants Malades Hospital, we identified three patients harboring three different pathogenic variants of the same amino acid residue Asn-549 located in this domain: in addition to a very typical crouzonoid appearance, they all developed clinically relevant hydrocephalus, which is an inconstant feature of Crouzon and Pfeiffer syndrome. Overall, FGFR2 tyrosine kinase domain mutations account for 5/67 (7.4% cases in our hospital. We describe a novel mutation, p.Asn549Ser, and new cases of p.Asn549His and p.Asn549Thr mutations, each reported once before. Our three cases of Asn-549 mutations, alongside with rare previously reported cases, show that these patients are at higher risk of hydrocephalus. Clinical and imaging follow-up, with possible early surgery, may help prevent secondary intellectual disability.

  17. The 1989 annual report of the Institut de Physique Nucleaire-Orsay

    International Nuclear Information System (INIS)

    1989-01-01

    The activity report of the Institut de Physique Nucleaire (Orsay-France) from 1 Sep 1988 to 1 Aug 1989 is presented. Theoretical and experimental investigations were carried out in the following fields: light and medium exotic nuclei, on line spectroscopy, discrete high spin states, new radioactivities, thermal fission, detection systems, giant resonances, high excitation energy structure, reaction mechanisms at energies below 10 MeV/u and at 200 MeV/u and their evolution between 10 and 100 MeV/u, meson production, transfer reactions, spin modes in nuclei, dibaryonic resonances, inelastic scattering of polarized protons. Research programs in the field of radiochemistry and relating to inter-disciplinary fields are included. The activities involving teaching, the lists of publications conferences, seminars and theses are presented [fr

  18. The French civilian nuclear: connections and stakes; Le nucleaire civil francais: filieres et enjeux

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This document (18 power point slides) gives an overview of the French civilian nuclear industry and research and development: importance of the nuclear power generation in France, excellence of the education in nuclear sciences, organization of the nuclear connection (CEA, Areva, EDF, IRSN), the role of the French International Nuclear Agency (AFNI), the requirements for a renewal of human resources (French and foreign engineers) in the field of nuclear energy, the degree course for a diploma, examples of engineer and university diplomas, the educational networks in various regions of France, presentation of the Institut National des Sciences et Techniques Nucleaires (Nuclear Sciences and Techniques National Institute) and its master degrees, organization of the French education system in nuclear sciences with strong relations with the research and development programs

  19. French research in the field of nuclear agronomy; Les recherches francaises en agronomie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Guerin De Montgareuil, P. [Commissariat a l' Energie Atomique, Cadarache (France). Centre d' Etudes Nucleaires

    1964-07-01

    , industrial firms, university laboratories scientific institutes. The role of the Commissariat a l'Energie Atomique is defined: on the one hand it supplies information and support, and on the other hand it takes charge of specifically nuclear aspects of the work. Its part in the field has recently found expression in the creation, within the Biology Department, of a Radio-agronomy Section; its objective are described,, as well as the, means placed att its disposal at the Centre d'etudes Nucleaires, Cadarache. (author) [French] On propose un bilan des travaux les plus significatifs effectues en France depuis la deuxieme conference internationale en matiere d'agronomie nucleaire et qui vont d'une recherche apparemment desinteressee a l'application la plus directe. Une telle differenciation recouvre de moins en moins, au fur et a mesure de l'evolution des programmes, la distinction qui est faite dans l'expose entre l'action biologique des rayonnements et les autres emplois des techniques nucleaires. C'est ainsi que les recherches do radiogenetique agricole sont poursuivies dans deux directions: d'un point de vue theorique et methodologique avec l'etude comparative de l'action des divers types de rayonnements, l'influence du debit de dose et de la temperature, l'action des agents mutagenes chimiques, la production de chimeres sous irradiation gamma; et d'autre part, sous un aspect pratique aboutissant a la creation de varietes nouvelles plus resistantes ou plus precoces (riz, mil, arachide). Les problemes de destruction des insectes (eradication) et de conservation des denrees sous irradiation se trouvent egalement abordes par des voies et avec des objectifs tres divers. A la demarche globale representee par une irradiation pure et simple (grains humides, pommes de terre...) sont parfois associees des etudes souvent originales, d'ordre biochimique ou microbiologique (par exemple: alteration de l

  20. Synthesis and characterization of ASnO3 (A = Ba, Ca, Sr) perovskites

    International Nuclear Information System (INIS)

    Seethalakshmi, V.; Bradha, M.; Vigneshwaran, J.; Kalaiselvi, V.; Sheeja, C.J.J.; Ashok, Anuradha

    2015-01-01

    Oxide materials with perovskite structure have exhibited excess of interesting physical properties such as superconductivity, ferroelectricity, piezoelectricity, and multiferroicity. Perovskite type oxide materials have the general formula ABO 3 having simple and flexible structures that can easily accommodate suitable dopants to create defects and oxygen non-stoichiometry. This makes the materials suitable for various applications such as catalysis, sensors, electrode materials for fuel cell applications etc. The alkaline earth stannates with chemical formula ASnO 3 (A = Ba, Sr, and Ca) is a perovskite system that has been used in industry for photoelectrochemical energy conversions, stable capacitors, and gas sensors. The transport properties of the stannates vary from insulating to metallic material subjected to temperature. In the present work, nano - sized ASnO 3 perovskite (A = Sa, Ca, Sr) were synthesized using chemical method followed by calcinations. The dried gel was subjected to thermogravimetry/differential scanning calorimetry (TG/DSC) to identify the perovskite phase formation. Phase purity and crystal structural analysis of the calcined samples were examined using powder X-ray diffraction (XRD). In addition, the local crystal structure and the particle morphology of the perovskites were examined by High resolution Transmission Electron Microscopy (HRTEM). The lattice fringes in the high resolution images can be interpreted according to the crystal structure obtained through XRD. The synthesized nanoperovskites can further be used for energy storage applications. (author)

  1. Leukaemia risks and exposure to ionizing radiations. ASN seminar, Tuesday, June 9, 2015, report

    International Nuclear Information System (INIS)

    Niel, Jean-Christophe; Samain, Jean-Paul; Colonna, Marc; Maynadie, Marc; Richardson, David; Bey, Pierre; Leuraud, Klervi; Laurier, Dominique; Hemon, Denis; Spycher, Ben; Kosti, Ourania; Bouville, Andre; Grosche, Bernd; Ziegelberger, Gunde; Kesminiene, Ausrele; Clavel, Jacqueline; Smeesters, Patrick; Murith, Christophe

    2015-08-01

    This seminar aims at proposing a review of present knowledge on leukaemia risks for children and adults associated with ionizing radiations, and at sharing knowledge between experts. After an introduction which outlined the interest of the ASN in research issues, and the importance awarded by the ASN to the variety of points of view, a first session addressed leukaemia and exposures to ionizing radiations. The contributions addressed some general aspects (an overview of leukaemia in France, the different types of adult and child leukaemia), leukaemia and acute exposures to ionizing radiations (ionizing radiation and leukaemia among Japanese bomb survivors, risks of leukaemia after radiotherapy), leukaemia and chronic exposures to ionizing radiations (assessment of epidemiological studies for adult chronic exposures). The second session addressed childhood leukaemia and ionizing radiations. The contributions of this second session more particularly addressed the following topics: childhood leukaemia and natural radioactivity (French studies, synthesis of international studies and a new Swiss study), childhood leukaemia and proximity of nuclear base installations (assessment of national and international studies, analysis of cancer risks in populations near nuclear facilities in the US, calculation of dose at the medulla as example of dosimetry of ionizing radiations and leukaemia, conclusions of the 2012 MELODI workshop), childhood leukaemia and scanner (recent results and perspectives), childhood leukaemia and other risk factors (etiology of childhood leukaemia - presentation of French studies initiated by the INSERM, and presentation of studies initiated by BfS)

  2. Decree n. 2007-534 of the 4. april 2007 allowing the creation of the base nuclear installation named Flamanville 3, including a EPR type reactor, on the site of Flamanville (Manche); Decret no 2007-534 du 10 avril 2007 autorisant la creation de l'installation nucleaire de base denommee Flamanville 3, comportant un reacteur nucleaire de type EPR, sur le site de Flamanville (Manche)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-04-15

    This decree gives the authorization to EDF to create on the site of Flamanville a nuclear installation including a PWR type reactor for a power of 4500 MW and devoted to the electric production. This reactor will can use uranium oxide or a mixture of uranium oxide and plutonium oxide. Considerations concerning the safety are given, as well as the control of the impact of this exploitation on the populations and the environment. (N.C.)

  3. Reports by the Parliamentary Office for scientific and technological assessment. Wednesday, March 30, 2011. 2010 activity report - Hearing of the Nuclear Safety Authority (ASN) college

    International Nuclear Information System (INIS)

    2011-03-01

    Members of the French Parliament and representatives of the French nuclear safety authority (ASN) discuss the content of the ASN 2010 activity report, the missions and responsibilities of the ASN in the different fields of exploitation of radioactive materials: nuclear energy and medical care. As far as nuclear energy is concerned, the representatives of the ASN evoke the decennial inspection of the French nuclear reactors, the control of the EPR construction, activities related to fuel cycle, the issue of waste management. As far as medical care is concerned, they address activities in the medical sector, the evolution of the number of events, and the commitment of the ASN in regulation elaboration. These issues are discussed with the members of Parliament

  4. Senate report n. 327 law project authorizing the approbation of international agreements on the civil liability in the domain of the nuclear energy; Senat rapport n. 327 projet de loi autorisant l'approbation d'accords internationaux sur la responsabilite civile dans le domaine de l'energie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The objective of this law project is to approve two protocols aiming to modify the OECD convention on the civil liability in the nuclear energy domain. After a short presentation of the international regime of civil liability in the nuclear domain with the Paris and Vienna conventions, the author analyzes the main improvements offered by the two protocols of February 2004 facing the french legislation. (A.L.B.)

  5. Renewal of release and sampling authorizations of the Cattenom nuclear power plant. Review of the public hearing file; Renouvellement des autorisations de rejets et de prelevements de la centrale nucleaire de Cattenom. Revue sommaire du dossier d'enquete publique

    Energy Technology Data Exchange (ETDEWEB)

    Marignac, Y.; Coeytaux, X

    2003-09-15

    In the frame of the regulatory system applicable to the French nuclear installations, EDF has asked for a renewal of water sampling and release licensing for the Cattenom nuclear power plant, demand submitted to a public hearing from the 25. of august to 30. of september 2003. It emerges from this analysis, that in spite of its important volume, the file presented by EDF shows essential lacks, in the data at the public disposal, in the methodological approach and in the explanations of operator choices. Consequently, the EDF demand does not appear in accordance with the obligations of public information, optimization of the impacts on environment and justification of these impacts. ( directive 85/337 on impact evaluation, EURATOM directive 96/29 on radiation protection, and directive 2000/60/CE on water policy). (N.C.)

  6. Project of decree relative to the licensing and statement system of nuclear activities and to their control and bearing various modifications of the public health code and working code; Projet de decret relatif au regime d'autorisation et de declaration des activites nucleaires et a leur controle et portant diverses modifications du code de la sante publique et du code du travail

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    This decree concerns the control of high level sealed radioactive sources and orphan sources. It has for objective to introduce administrative simplification, especially the radiation sources licensing and statement system, to reinforce the control measures planed by the public health code and by the employment code, to bring precision and complements in the editing of several already existing arrangements. (N.C.)

  7. Bill project authorizing the approval of the amendment to the Convention on the physical protection of nuclear materials; Projet de loi autorisant l'approbation de l'amendement a la convention sur la protection physique des matieres nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Juppe, Alain [Ministere des Affaires Etrangeres et Europeennes, 37 Quai d' Orsay, 75007 Paris (France); Fillon, Francois [Premier ministre, Hotel de Matignon, 57, rue de Varenne, 75700 Paris (France)

    2011-12-01

    This document deals with the amendment to the Convention on the Physical Protection of Nuclear Materials which has been adopted in July 2005. This amendment notably extended the Convention's scope, objectives, relation with other international instruments and content (regarding cooperation, sanctions, and so on). After the text of this amendment, this document contains the bill project which reports an impact study (estimated economic, financial, environmental, and legal consequences of the amendment implementation), comments the penal and criminal cooperation defined in the Convention. A table indicates the impact of the amendment's articles on the French law

  8. Evaluation guideline for the study of the radiological impact of based nuclear installations (INB) presented in support of releases authorization demands; Guide d'examen pour l'etude de l'impact radiologique d'une installation nucleaire de base (INB) fournie a l'appui des demandes d'autorisation de rejets

    Energy Technology Data Exchange (ETDEWEB)

    Chartier, M.; Despres, A.; Supervil, S.; Conte, D.; Hubert, P.; Oudiz, A.; Champion, D

    2002-10-01

    In the case of a license demand for the effluents release and water taking for a nuclear installation, the operating must realize a study of the nuclear effluents radiological impact on the environment and the public health. In this context, the study presents technical and methodological specifications which led the Direction of the Nuclear Installations Safety (DSIN) and the General Direction of the Health (DGS) to ask the IPSN the elaboration of a guideline to help these studies evaluation. The guideline presents the regulatory context, the description of the installations, the treatment and the control processes, the rules of management, the description of the environment, the estimation of the radiological impacts and the environment control system definition. (A.L.B.)

  9. Lack of association between urotensin-II (UTS2 gene polymorphisms (Thr21Met and Ser89Asn and migraine

    Directory of Open Access Journals (Sweden)

    Betül Ozan

    2017-08-01

    Full Text Available Migraine is a common neurovascular brain disorder with heterogeneous clinical presentation, including recurrent headache attacks. The pathophysiology of migraine is complex, and a number of genomic regions have been associated with the development of migraine. In this study, we analyzed the allele and genotype frequencies of the urotensin-II gene (UTS2 polymorphisms, Thr21Met and Ser89Asn, among Turkish patients with migraine. A total of 146 patients with migraine (14 with aura [MA group] and 132 without aura [MO group] were genotyped for Thr21Met and Ser89Asn polymorphisms and compared with 154 age- and sex-matched healthy controls. The UTS2 gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP. No significant differences were observed in allele and genotype frequencies for Thr21Met and Ser89Asn polymorphisms between the patients with migraine and control group. Similarly, we did not observe significant differences in allele and genotype frequencies between MA and MO and control group. Moreover, the haplotype analysis showed no association between UTS2 gene haplotypes (MN, MS, TN, and TS and migraine. In summary, Thr21Met and Ser89Asn polymorphisms of the UTS2 gene are not risk factors for migraine in our sample of Turkish migraine patients.

  10. Cyclization of the N-Terminal X-Asn-Gly Motif during Sample Preparation for Bottom-Up Proteomics

    DEFF Research Database (Denmark)

    Zhang, Xumin; Højrup, Peter

    2010-01-01

    We, herein, report a novel -17 Da peptide modification corresponding to an N-terminal cyclization of peptides possessing the N-terminal motif of X-Asn-Gly. The cyclization occurs spontaneously during sample preparation for bottom-up proteomics studies. Distinct from the two well-known N...

  11. ASN Report on the state of nuclear safety and radiation protection in France in 2012 - Annual report 2012

    International Nuclear Information System (INIS)

    2013-01-01

    After a presentation of the roles, key figures and organization of the ASN (the French Agency for nuclear safety), a review of significant events which occurred in 2012, and an overview of ASN actions following the Fukushima accident, the first part of this annual report proposes a large review of ASN actions in different fields: nuclear activities (ionizing radiation and health and environmental risks), principles and stakeholders in the regulation of nuclear safety and radiation protection, regulations of nuclear activities and exposure to ionizing radiation, radiological emergency and post-accident situations, public information and transparency, international relations, regional overview in the field of nuclear safety and radiation protection. The second part addresses the activities regulated by the ASN: medical uses of ionizing radiation, industrial, research and veterinary uses and source security, transport of radioactive substances, nuclear power plants, nuclear fuel cycle installations, nuclear research facilities and various other nuclear installations, safe decommissioning of basic nuclear installations, radioactive waste and contaminated sites and soils

  12. A lipoprotein lipase mutation (Asn291Ser) is associated with reduced HDL cholesterol levels in premature atherosclerosis

    NARCIS (Netherlands)

    Reymer, P.W.A.; Gagné, S E; Groenemeyer, B E; Zhang, H; Forsyth, I; Jansen, H; Seidell, J C; Kromhout, D.; Lie, K E; Kastelein, J.J.

    1995-01-01

    A reduction of high density lipoprotein cholesterol (HDC) is recognized as an important risk factor for coronary artery disease (CAD). We now show in approximately 1 in 20 males with proven atherosclerosis that an Asn291Ser mutation in the human lipoprotein lipase (LPL) gene is associated with

  13. ASN guide project. Safety policy and management in INBs (base nuclear installations)

    International Nuclear Information System (INIS)

    2010-01-01

    This guide presents the recommendations of the French Nuclear Safety Authority (ASN) in the field of safety policy and management (PMS) for base nuclear installations (INBs). It gives an overview and comments of some prescriptions of the so-called INB order and PMS decision. These regulatory texts define a framework for provisions any INB operator must implement to establish his safety policy, to define and implement a system which allows the safety to be maintained, the improvement of his INB safety to be permanently looked for. The following issues are addressed: operator's safety policy, identification of elements important for safety, of activities pertaining to safety, and of associated requirements, safety management organization and system, management of activities pertaining to safety, documentation and archiving

  14. The ASN imposes on EDF complementary requirements for the setting of the hard-core unit

    International Nuclear Information System (INIS)

    Anon.

    2014-01-01

    In January 2014, the ASN (French Authority for Nuclear Safety) published a list of 19 decisions concerning the implementation of a 'post-Fukushima' hard-core unit in each EDF nuclear power plant. The purpose of the hard-core unit is to have structures and equipment able to resist very extreme events and able to assure the vital functions necessary for the reactor safety. The 19 decisions detail the rules for the design of the hard-core unit. For example the hard-core unit will have to resist earthquakes for which the probability of occurrence is about 1 every 20.000 years while the probability taking into account for the design of the reactor is only 1 every 1000 or 10.000 years

  15. Mutation of Asn28 Disrupts the Dimerization and Enzymatic Activity of SARS 3CL

    Energy Technology Data Exchange (ETDEWEB)

    Barrila, J.; Gabelli, S; Bacha, U; Amzel, M; Freire, E

    2010-01-01

    Coronaviruses are responsible for a significant proportion of annual respiratory and enteric infections in humans and other mammals. The most prominent of these viruses is the severe acute respiratory syndrome coronavirus (SARS-CoV) which causes acute respiratory and gastrointestinal infection in humans. The coronavirus main protease, 3CL{sup pro}, is a key target for broad-spectrum antiviral development because of its critical role in viral maturation and high degree of structural conservation among coronaviruses. Dimerization is an indispensable requirement for the function of SARS 3CL{sup pro} and is regulated through mechanisms involving both direct and long-range interactions in the enzyme. While many of the binding interactions at the dimerization interface have been extensively studied, those that are important for long-range control are not well-understood. Characterization of these dimerization mechanisms is important for the structure-based design of new treatments targeting coronavirus-based infections. Here we report that Asn28, a residue 11 {angstrom} from the closest residue in the opposing monomer, is essential for the enzymatic activity and dimerization of SARS 3CLpro. Mutation of this residue to alanine almost completely inactivates the enzyme and results in a 19.2-fold decrease in the dimerization K{sub d}. The crystallographic structure of the N28A mutant determined at 2.35 {angstrom} resolution reveals the critical role of Asn28 in maintaining the structural integrity of the active site and in orienting key residues involved in binding at the dimer interface and substrate catalysis. These findings provide deeper insight into complex mechanisms regulating the activity and dimerization of SARS 3CL{sup pro}.

  16. Significant event of patient radiation protection in radiotherapy (criterion 2.1): declaration and rating on the ASN-SFRO scale - ASN guide no. 16 - Release of 17/07/2015

    International Nuclear Information System (INIS)

    2015-01-01

    This document is an update of the previous version from October 2010. It brings together all the tools for the management of a significant event in radiation protection concerning a patient in radiotherapy. It contains the declaration form, a model for the reporting of significant events, and the ASN-SFRO scale which allows the event to be rated. After a presentation of the regulatory context and references, of the scope of application, this guide addresses the declaration of a significant event: general principles, definition of the 2.1 criterion, examples, delays and modalities of declaration, addressees of a declaration. It addresses the reporting of a significant event: general principles, sending delays and modalities. It addresses the rating on the ASN-SFRO scale: general principles, scale, and rating process. The last part deals with public information

  17. Significant event of patient radiation protection in radiotherapy (criterion 2.1): declaration and rating on the ASN-SFRO scale - ASN guide nr 16 - Release of the 01/01/2010

    International Nuclear Information System (INIS)

    2010-01-01

    This document brings together all the tools for the management of a significant event in radiation protection concerning a patient in radiotherapy. It contains the declaration form, a model for the reporting of significant events, and the ASN-SFRO scale which allows the event to be rated. After a presentation of the regulatory context and references, of the scope of application, this guide addresses the declaration of a significant event: general principles, definition of the 2.1 criterion, examples, delays and modalities of declaration, addressees of a declaration. It addresses the reporting of a significant event: general principles, sending delays and modalities. It addresses the rating on the ASN-SFRO scale: general principles, scale, and rating process. The last part deals with public information

  18. ASN inspection of waste processing facilities operated by the CEA in the Ile-de-France region; Le controle par l'ASN des installations de traitement des dechets exploitees par le CEA en Ile-de-France

    Energy Technology Data Exchange (ETDEWEB)

    Baraer, B. [Autorite de Surete Nucleaire, inspecteur de la surete nucleaire a la Division d' Orleans, 75 - Paris (France)

    2011-02-15

    ASN (French Nuclear Safety Authority) ensures that safety at nuclear radioactive waste processing and storage facilities is maintained at an acceptable level and, where this is not the case, requires that facilities be brought up to standard. The specific characteristic of such facilities, which are often old, have to satisfy demand for reprocessing the waste currently produced by nuclear facilities and also meet the need to manage old waste storage facilities that were designed to comply with standards that are now out-of-date. This has led the operator first to set up new, higher performance facilities or workshops and, second, to carry out works on these old waste storage sites or transfer this waste to more suitable facilities. All these various projects result in major changes being made to these facilities. Based on the information supplied by the operator, ASN ensures that the safety analysis is satisfactory and, by means of spot checks, verifies that operations are conducted in compliance with procedures resulting from this analysis. In addition, INB (nuclear facilities) operating activities are often out-sourced. ASN checks that the implementation of such activities and monitoring of the subcontractor by the operator meet the applicable regulatory requirements. The examples of the waste processing INBs at the CEA sites at Fontenay-aux-Roses and Saclay perfectly illustrate the above. (author)

  19. Analytic catalog for the use of the nuclear physicists; Repertoire analytique a l'usage des physiciens nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Ballini, R.; Barloutaud, R.; Bernas, R.; Chaminade, R.; Cohen, R.; Conjeaud, M.; Cotton, E.; Faraggi, H.; Grjebine, T.; Laboulaye, H. de; Lehmann, P.; Leveque, A.; Levi, C.; Moreau, J.; Naggiar, V.; Olkowsky, J.; Papineau, L.; Papineau, L.; Prugne, P.; Schuhl, C.; Szteinsznaider, D.; Tzara, C.; Valladas, G. [Commissariat a l' Energie Atomique, Saclay(France). Centre d' Etudes Nucleaires; Marty, N.; Renard, G. [College de France, Lab. de Chimie Nucleaire (France)

    1952-07-01

    The problem of the documentation in nuclear physics becomes constantly more complex. Every week brings its share of publications, always more numerous and more varied. To remedy to this problem, we tried, at the Nuclear Physics Services of the CEA, to give to the documentation the character of a collective and systematized work. The present report covers the literature appeared between January 1, 1950 and July 1, 1951. (Volume 1: CEA report number 120; Volume 2: CEA report number 184). (M.B.) [French] Le probleme de la documentation en physique nucleaire devient sans cesse plus complexe. Chaque semaine apporte son lot de publications, toujours plus nombreuses et plus diversifiees. C'est pour essayer de porter remede a cet etat de choses que nous avons essaye, au service de Physique Nucleaire du C.E.A., de donner a la documentation le caractere d'un travail collectif systematise. Le present rapport couvre la litterature parue entre le 1 Janvier 1950 et le 1 Juillet 1951. (Tome 1: Rapport CEA numero 120; Tome 2: Rapport CEA numero 184). (M.B.)

  20. Asn792 participates in the hydrogen bond network around the K+-binding pocket of gastric H,K-ATPase.

    NARCIS (Netherlands)

    Swarts, H.G.P.; Koenderink, J.B.; Willems, P.H.G.M.; Krieger, E.; Pont, J.J.H.H.M. de

    2005-01-01

    Asn792 present in M5 of gastric H,K-ATPase is highly conserved within the P-type ATPase family. A direct role in K+ binding was postulated for Na,K-ATPase but was not found in a recent model for gastric H,K-ATPase (Koenderink, J. B., Swarts, H. G. P., Willems, P. H. G. M., Krieger, E., and De Pont,

  1. From crisis exercises to the management of emergency situations...The experience of a local branch of ASN

    International Nuclear Information System (INIS)

    Deproit, L.; Vieuble, J.

    2016-01-01

    The local branch of the ASN (Nuclear Safety Authority) in the Marseille region controls the nuclear activities in 13 departments and Corsica. The preparation of the crisis management relies on the involvement of various actors: representatives of public bodies, nuclear plant operators, the ASN and its technical assistance (IRSN - Institute for Radiation-protection and Nuclear Safety). Crisis exercises are necessary to check the right coordination of all the actors. The feedback of real situations involving incidents are also important because it allows all the actors to better know each other, the case of the accident of the Centraco facility is detailed as well as the robbery of a truck carrying a radioactive source or the discovery of a collection of radioactive sources in a private home. In each case the lesson learned by the local branch of ASN is to communicate quickly with local authorities in order to get the best technical response to the situation and to give authorities all the information necessary for an efficient information of the public. (A.C.)

  2. Genetic polymorphisms ofUTS2rs2890565 Ser89Asn in cardiac hypertrophy in Chinese Han population.

    Science.gov (United States)

    Zhao, Jing; Jiang, Jie; Wang, Jie; Liu, Lin; Han, Xiao-Ning; Chu, Song-Yun; Xue, Lin; Ding, Wen-Hui

    2017-07-01

    Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic stimuli, some of which might finally lead up to a maladaptive state. Clinical evidence, in vitro and in vivo studies have implicated urotensin II (U-II/UTS2) in the development of cardiac hypertrophy, contributing to the (patho)-physiological regulation of cardiovascular homeostasis in humans. Several genes are associated with left ventricular hypertrophy; considering these, our objective was to evaluate the possible role of UTS2 gene polymorphisms (Thr21Met and Ser89Asn) in the genetic susceptibility to cardiac hypertrophy in a Chinese population. A case-control study was designed to compare the distribution of alleles and genotypes between three groups: case group 1 (subjects with hypertension and cardiac hypertrophy, n=265), case group 2 (subjects with hypertension, without cardiac hypertrophy, n=768), and the control group (subjects neither with hypertension nor with cardiac hypertrophy, n=416). The detection of UTS2 gene polymorphisms was achieved with the PCR restriction fragment length polymorphism technique. We did not identify statistically significant differences between the three groups, neither with regard to the frequency of genotype/variant at the Ser89Asn locus nor at the Thr21Met locus. When stratified by sex, differences in genotype distribution of polymorphism Ser89Asn were only seen in female subjects in both the additive tested inheritance model (OR=0.507, 95% CI 0.249 to 1.032, p=0.032) and the recessive tested inheritance model (OR=0.475, 95% CI 0.239 to 0.945, p=0.034) between case group 2 (subjects with hypertension, without cardiac hypertrophy) and the control group (subjects neither with hypertension nor with cardiac hypertrophy). When stratified by sex, for female subjects with cardiac hypertrophy, we identified statistically significant differences in left ventricular posterior wall thickness for variant genotypes at the Ser89Asn locus (AA vs GG: 1

  3. Novel mutations (Asn 484 Lys, Thr 500 Ala, Gly 438 Glu) in Morquio B disease.

    Science.gov (United States)

    Bagshaw, Richard D; Zhang, Sunqu; Hinek, Alina; Skomorowski, Marie Anne; Whelan, Donald; Clarke, Joe T R; Callahan, John W

    2002-12-12

    Primary deficiency of beta-galactosidase results in GM1 gangliosidosis and Morquio B disease. Of the more than 40 disease-causing mutations described in the Gal gene to date, about 75% are of the missense type and are scattered along the length of the gene. No single, major common mutation has been associated with GM1 gangliosidosis. However, a Trp 273 Leu mutation has been commonly found in the majority of patients with Morquio B disease defined genotypically to date. We now report three new mutations in three Morquio B patients where the Trp 273 Leu mutation is absent. Two of the mutations, C1502G (Asn 484 Lys) and A1548G (Thr 500 Ala), were found in twins (one male, one female) who display a mild form of Morquio B disease and keratan sulfate in the urine. In their fibroblasts, residual activity was 1.9% and 2.1% of controls. On Western blots, the 84-kDa precursor and the 64-kDa mature protein were barely detectable. The occurrence of a 45-kDa degradation product indicates that the mutated protein reached the lysosome but was abnormally processed. In the third case, we identified only a G1363A (Gly 438 Glu) mutation (a major deletion on the second allele has not been ruled out). This female patient too displays a very mild form of the disease with a residual activity of 5.7% of control values. In fibroblasts from this case, the 84-kDa precursor and the 45-kDa degradation product were present, while the mature 64-kDa form was barely detectable. The occurrence of these three mutations in the same area of the protein may define a domain involved in keratan sulfate degradation.

  4. Contribution to the study of thermal mixing between nuclear spin systems; Contribution a l'etude du melange thermique entre systemes de spins nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Goldmann, M. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-02-15

    This work describes methods of dynamic nuclear polarization in solids based on the thermal mixing between nuclear spin systems. The description of the thermal mixing processes involves most of the fundamental aspects of the spin temperature theory. The experiments, conducted with paradichlorobenzene and para-dibromobenzene, yield a detailed confirmation of the theoretical predictions. (author) [French] Ce travail decrit des methodes de polarisation dynamique nucleaire dans les solides basees sur le melange thermique entre systemes de spins nucleaires. La description des processus de melange thermique met en jeu la plupart des aspects fondamentaux de la theorie de la temperature de spin. Les experiences, realisees avec du paradichlorobenzene et du paradibromobenzene, apportent une confirmation detaillee des previsions theoriques. (auteur)

  5. Economic consequences of the Swiss 'Sortir du nucleaire' and 'Moratoire-plus' popular initiatives - Analysis using a balanced model

    International Nuclear Information System (INIS)

    Mueller, A.; Wickart, M.; Van Nieuwkoop, R.

    2001-01-01

    This article is a short version of the ENET number 210359. This report for the Swiss Federal Office of Energy (SFOE) presents the results of a study made to assess the economic consequences of two models for the opting out of nuclear energy in Switzerland, as proposed in two popular initiatives. The 'Sortir du nucleaire' (electricity without atomic power) initiative calls for the shutting down of the existing nuclear power stations and the 'Moratoire-plus' initiative calls for a stop on the building of new atomic power stations for 10 years. The method used for assessing the costs and benefits resulting if the initiatives were accepted in a public vote is described. Basic assumptions made on further factors concerning the electricity and energy markets are discussed. Results of analyses made for various scenarios with respect to CO 2 emissions are presented and include discussions on risk costs, effects on employment and welfare aspects

  6. Ser95, Asn97, and Thr78 are important for the catalytic function of porcine NADP-dependent isocitrate dehydrogenase

    OpenAIRE

    Kim, Tae-Kang; Colman, Roberta F.

    2005-01-01

    The mammalian mitochondrial NADP-dependent isocitrate dehydrogenase is a citric acid cycle enzyme and an important contributor to cellular defense against oxidative stress. The Mn2+-isocitrate complex of the porcine enzyme was recently crystallized; its structure indicates that Ser95, Asn97, and Thr78 are within hydrogen-bonding distance of the γ-carboxylate of enzyme-bound isocitrate. We used site-directed mutagenesis to replace each of these residues by Ala and Asp. The wild-type and mutant...

  7. Demand of authorization to create the 'Flamanville 3' Basis Nuclear Installation. Synthesis report of the technical examination; Demande d'autorisation de creation de l'INB 'Flamanville 3'. Rapport de synthese de l'examen technique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-02-15

    The present report has for objective to present to the College of Asn a synthesis of the technical instruction piloted by the services of Asn and realized by their technical supports (I.R.S.N., G.P.R., S.P.N.) during the period 2001-2006. After a reminder of the conditions of the examination of the safety options of the project EPR made between 1993 and 2000, this report explains the progress and the modalities of the instruction realized from 2001 till 2006. It draws up then, besides a notice of the Asn services at request of creation authorization, a synthesis of the technical examination realized according to axes presented on the fig 1. Finally, it presents the main lines of the examination that it would stay to realize if the creation authorization was delivered. (N.C.)

  8. The nuclear safety authority (ASN) presents its report on the status of nuclear safety and radiation protection in France in 2010

    International Nuclear Information System (INIS)

    2011-01-01

    After a presentation of the French nuclear safety authority (ASN) and of some events which occurred in 2010, this report present the actions performed by the ASN in different fields: nuclear activities (ionizing radiations and risks for health and for the environment), principles and actors of control of nuclear safety, radiation protection and environment protection, regulation, control of nuclear activities and of exposures to ionizing radiations, emergency situations, public information and transparency, international relationship. It proposes a regional overview of nuclear safety and radiation protection in France. It addresses the activities controlled by the ASN: medical and non medical usages of ionizing radiations, transportation of radioactive materials, electronuclear power stations, installations involved in the nuclear fuel cycle, research nuclear installations and other nuclear installations, safety in basic nuclear installation dismantling, radioactive wastes and polluted sites

  9. First report of Ser653Asn mutation endowing high-level resistance to imazamox in downy brome (Bromus tectorum L.).

    Science.gov (United States)

    Kumar, Vipan; Jha, Prashant

    2017-12-01

    Bromus tectorum L. is one of the most troublesome grass weed species in cropland and non-cropland areas of the northwestern USA. In summer 2016, a B. tectroum accession (R) that survived imazamox at the field-use rate (44 g ha -1 ) in an imidazolinone-tolerant (IMI-tolerant or Clearfield™) winter wheat field was collected from a wheat field in Carter County, MT, USA. The aim of this study was to determine the resistance profile of the B. tectroum R accession to imazamox and other ALS inhibitors, and investigate the mechanism of resistance to imazamox. The R B. tectorum accession had a high-level resistance (110.1-fold) to imazamox (IMI) and low to moderate-levels cross-resistance to pyroxsulam (TP) (4.6-fold) and propoxycarbazone (SCT) (13.9-fold). The R accession was susceptible to sulfosulfuron (SU) and quizalofop and clethodim (ACCase inhibitors), paraquat (PS I inhibitor), glyphosate (EPSPS inhibitor) and glufosinate (GS inhibitor). Sequence analysis of the ALS gene revealed a single, target-site Ser653Asn mutation in R plants. Pretreatment of malathion followed by imazamox at 44 or 88 g ha -1 did not reverse the resistance phenotype. This is the first report of evolution of cross-resistance to ALS-inhibiting herbicides in B. tectorum. A single-point mutation, Ser653Asn, was identified, conferring the high-level resistance to imazamox. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  10. Report by the ASN on the situation of nuclear safety and radiation protection in France in 2013

    International Nuclear Information System (INIS)

    Chevet, Pierre-Franck; Delmestre, Alain; Bardet, Marie-Christine; Covard, Fabienne; Javay, Olivier

    2014-01-01

    In its first chapters, this huge report presents the various actions undertaken by the ASN. It proposes a detailed overview of the issue of ionizing radiations and risks for health and for the environment in the field of nuclear activities, presents and comments the principles and actors of the control of nuclear safety and of radiation protection, presents the different elements of the legal framework, describes and comments the control of nuclear activities and of exposures to ionizing radiations. The next chapters address the actions controlled by the ASN: radiological and post-accidental radiological situations, present measures related to public information and transparency, overview of international relationships, regional overview of nuclear safety and radiation protection, medical use of ionizing radiations, industrial, research and veterinary uses and the issue of source safety, the issue of radioactive material transportation. Issues of nuclear safety and radiation protection are then discussed for electronuclear plants, for installations dedicated to the nuclear fuel cycle, for various research and industrial nuclear installations, for the dismantling of base nuclear installations, and for radioactive wastes and polluted sites and soils

  11. Inspection of nuclear pressure equipment: principles, issues and perspectives; Le controle des equipements sous pression nucleaires: principes, enjeux et perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Limousin, S. [Autorite de Surete Nucleaire (ASN), Dir. des Equipements sous Pression Nucleaires, 75 - Paris (France)

    2010-02-15

    French regulations about nuclear pressure equipment (like steam generators and the reactor pressure vessel) take into account hazards due to the energy contained in the equipment but also add specific requirements due for instance to the radioactivity or safety for instance. ASN is in charge of the conformity assessment of the most important equipment and monitors the licensee who is responsible of in service inspection and maintenance. Because of the internationalization of nuclear component manufacturing, and consequently new comers in this area, a careful monitoring of subcontractors is needed. The major anomalies detected in steam generator over the past few years showed the necessity of being careful and humble towards degradation mechanisms. Nuclear pressure equipment regulations enables ASN to perform an efficient oversight of licensees and component manufacturer in a context of international manufacturing and licence renewal. (author)

  12. ASN guide project. Safety policy and management in INBs (base nuclear installations); Projet de guide de l'ASN. Politique et management de la surete dans les INB

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This guide presents the recommendations of the French Nuclear Safety Authority (ASN) in the field of safety policy and management (PMS) for base nuclear installations (INBs). It gives an overview and comments of some prescriptions of the so-called INB order and PMS decision. These regulatory texts define a framework for provisions any INB operator must implement to establish his safety policy, to define and implement a system which allows the safety to be maintained, the improvement of his INB safety to be permanently looked for. The following issues are addressed: operator's safety policy, identification of elements important for safety, of activities pertaining to safety, and of associated requirements, safety management organization and system, management of activities pertaining to safety, documentation and archiving

  13. Glycosylation beyond the Asn78-linked GlcNAc residue has a significant enhancing effect on the stability of the α subunit of human chorionic gonadotropin

    NARCIS (Netherlands)

    Vliegenthart, J.F.G.; Zuylen, C.W.E.M. van; Kamerling, J.P.

    1997-01-01

    The effects of glycosylation beyond the Asn-linked GlcNAc residues on the stability of the α subunit of human chorionic gonadotropin are investigated, using enzymatic deglycosylation and NMR spectroscopy. Comparison of thermal denaturation profiles of both the intact α subunit and the α subunit

  14. [Different expression of the Asn264LysfsX35 mutation of the GNAS gene in a family with pseudohypoparathyroidism.].

    Science.gov (United States)

    de Arriba Muñoz, A; Labarta Aizpún, J I; Dehesa, E Mayayo; Calvo, M T; Pérez de Nanclares, G; Ferrández-Longás, A

    2011-02-01

    Pseudohypoparathyroidism (PHP) is a heterogeneous group of endocrine diseases characterised by hypocalcaemia, hyperphosphataemia and resistance to PTH. There are different forms of PHP. PHP-Ia is the most frequent form and shows multi-hormonal resistance, GNAS (Gs(α)) mutations and signs of Albright́s hereditary osteodystrophy (AHO). PseudoPHP (PPHP) have isolated AHO without hormonal resistance and it is also caused by GNAS mutations. We present a family that share the same inactivating GNAS mutation (Asn264LysfsX35); the mother being affected with PPHP and the two daughters with PHP-Ia. We discuss the different clinical phenotypes and the dominant mode of inheritance with genetic imprinting where the phenotype of the offspring depends on the sex of the parent affected. Copyright © 2010 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

  15. Asn-150 of Murine Erythroid 5-Aminolevulinate Synthase Modulates the Catalytic Balance between the Rates of the Reversible Reaction.

    Science.gov (United States)

    Stojanovski, Bosko M; Ferreira, Gloria C

    2015-12-25

    5-Aminolevulinate synthase (ALAS) catalyzes the first step in mammalian heme biosynthesis, the pyridoxal 5'-phosphate (PLP)-dependent and reversible reaction between glycine and succinyl-CoA to generate CoA, CO2, and 5-aminolevulinate (ALA). Apart from coordinating the positioning of succinyl-CoA, Rhodobacter capsulatus ALAS Asn-85 has a proposed role in regulating the opening of an active site channel. Here, we constructed a library of murine erythroid ALAS variants with substitutions at the position occupied by the analogous bacterial asparagine, screened for ALAS function, and characterized the catalytic properties of the N150H and N150F variants. Quinonoid intermediate formation occurred with a significantly reduced rate for either the N150H- or N150F-catalyzed condensation of glycine with succinyl-CoA during a single turnover. The introduced mutations caused modifications in the ALAS active site such that the resulting variants tipped the balance between the forward- and reverse-catalyzed reactions. Although wild-type ALAS catalyzes the conversion of ALA into the quinonoid intermediate at a rate 6.3-fold slower than the formation of the same quinonoid intermediate from glycine and succinyl-CoA, the N150F variant catalyzes the forward reaction at a mere 1.2-fold faster rate than that of the reverse reaction, and the N150H variant reverses the rate values with a 1.7-fold faster rate for the reverse reaction than that for the forward reaction. We conclude that the evolutionary selection of Asn-150 was significant for optimizing the forward enzymatic reaction at the expense of the reverse, thus ensuring that ALA is predominantly available for heme biosynthesis. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  16. Nuclear developments at the international inter govern mental level (1961); Developpements nucleaires sur le plan international intergouvernemental (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Waynbaum, M. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1961-07-01

    The United Nations organisation and nuclear energy rose simultaneously, in 1945, to occupy an important place in the public eye. The spiritual succession of the League of Nations which had foundered during the war was taken up by the new organisation which sought to implant its political ideal in a more tangible reality, so that it might thereby be inspired by concrete and substantial objectives. This is one of the reasons for the existence of the dozen specialized agencies created by the family of the United Nations and dealing with Health, Culture, Agriculture, Finance, etc. Nuclear energy is one of these techniques. Becoming suddenly an important power factor and exploiting for itself the prestige of Science, it became the favorite domain for the growth of this new spirit, as much in its universal form in 1945 as in its more regional form which it was later to adopt. The achievements are numerous and of varying importance; they deserve te be studied carefully. (author) [French] L'organisation des Nations Unies et le nucleaire ont ete places simultanement, en 1945, au premier plan de la scene mondiale. La Societe des Nations ayant sombre pendant la guerre, son heritage spirituel fut recueilli par la nouvelle organisation qui chercha a enraciner son ideal politique dans une realite plus materielle, de facon a y puiser une nourriture concrete et substantielle. C'est une des raisons d'existence de la douzaine d'institutions specialisees gravitant dans la famille des Nations Unies et s'occupant de Sante, de Culture, d'Agriculture, de Finances, etc. Le nucleaire est l'une de ces techniques. Devenu soudainement un facteur primordial de puissance, Cristallisant a son benefice le prestige de la Science, c'etait un terrain de predilection pour le developpement du nouvel esprit, aussi bien sous la forme universelle de 1945, que sous les formes regionales qui ont vu le jour ensuite. Les travaux realises que nombreux, d

  17. Evidence that Asn542 of neprilysin (EC 3.4.24.11) is involved in binding of the P2' residue of substrates and inhibitors.

    Science.gov (United States)

    Dion, N; Le Moual, H; Fournié-Zaluski, M C; Roques, B P; Crine, P; Boileau, G

    1995-01-01

    Neprilysin (EC 3.4.24.11) is a Zn2+ metallopeptidase involved in the degradation of biologically active peptides, e.g. enkephalins and atrial natriuretic peptide. The substrate specificity and catalytic activity of neprilysin resemble those of thermolysin, a crystallized bacterial Zn2+ metalloprotease. Despite little overall homology between the primary structures of thermolysin and neprilysin, many of the amino acid residues involved in catalysis, as well as Zn2+ and substrate binding, are highly conserved. Most of the active-site residues of neprilysin have their homologues in thermolysin and have been characterized by site-directed mutagenesis. Furthermore, hydrophobic cluster analysis has revealed some other analogies between the neprilysin and thermolysin sequences [Benchetrit, Bissery, Mornon, Devault, Crine and Roques (1988) Biochemistry 27, 592-596]. According to this analysis the role of Asn542 in the neprilysin active site is analogous to that of Asn112 of thermolysin, which is to bind the substrate. Site-directed mutagenesis was used to change Asn542 to Gly or Gln residues. The effect of these mutations on substrate catalysis and inhibitor binding was examined with a series of thiorphan-like compounds containing various degrees of methylation at the P2' residue. For both mutated enzymes, determination of kinetic parameters with [D-Ala2,Leu5]enkephalin as substrate showed that the large decrease in activity was attributable to an increase in Km (14-16-fold) whereas kcat values were only slightly affected (2-3-fold decrease). This is in agreement with Asn542 being involved in substrate binding rather than directly in catalysis. Finally, the IC50 values for thiorphan and substituted thiorphans strongly suggest that Asn542 of neprilysin binds the substrate on the amino side of the P2' residue by formation of a unique hydrogen bond. Images Figure 2 Figure 3 PMID:7487905

  18. Nuclear Safety and Radiation Protection in France in 2005; La surete nucleaire et la radioprotection en France en 2005. Dossier de presse

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-04-15

    In 2005, the Asn pursued its significant investment in radiation protection and reaffirms its ambition to become as efficient in radiation protection as it is in nuclear safety as of 2009. 2005 was a year of great progress for the Asn as it consolidated its organisation and working methods, in accordance with the 2005-2007 strategic plan it set for itself. The Asn continued progress in the field of radiation protection has given rise to various new regulations to improve the legislative and regulatory framework in this area. The Asn plans to step up its efforts to ensure better monitoring of patient exposure to ionizing radiation and to provide better management of radon-related risks, particularly in housing. Fully aware that its newfound power in this area requires outside evaluation, the Asn has asked the International Atomic Energy Agency (IAEA) to organize an I.R.R.S. (Integrated Regulatory Review Service) assignment consisting of a peer-conducted audit. The IAEA has confirmed that this audit will take place in November 2006. (N.C.)

  19. Evolution of nuclear chemical industry in France; Evolution de l'industrie chimique nucleaire en France

    Energy Technology Data Exchange (ETDEWEB)

    Fould, M.H. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1959-07-01

    'impulsion du CEA, mais aussi de maitres d'oeuvres tels qu'Electricite de France et la Marine Marchande, l'effort nucleaire fran is atteint pour les annees 1957-1961, environ 600 milliards de francs: plus de la moitie de cette somme sera depensee par l'industrie chimique en recherches, installations pilotes, constructions d'usines et livraisons. Faire bien, vite et rentable sont les buts recherches. Ces objectifs sont atteints grace a une collaboration intime des grands services de l'etat et de l'industrie privee. Ce gros effort s'exerce principalement dans les voies suivantes: - Un traitement chimique pousse de tonnages croissants des minerais de l'Union fran ise, visant a produire un uranium pur, abondant et bon marche. - Une preparation soigneuse de combustibles nucleaires economiques et parfaitement adaptes aux divers types de reacteurs en fonctionnement ou en construction. - Un retraitement des combustibles irradies pour en extraire le plutonium de facon complete ainsi que l'uranium et certains produits de fission. - Une fabrication industrielle des materiaux nucleairement purs ou resistants a la corrosion exiges par la technologie des reacteurs producteurs d'energie et de recherches. - La fourniture aux multiples utilisateurs etrangers et fran is d'isotopes et de traceurs radioactifs reclames par la medecine, l'industrie et l'agriculture en nombre toujours croissant. - Un traitement chimique meticuleux des effluents gazeux ou liquides dans des stations au controle rigoureux afin de rendre les reacteurs et leurs annexes parfaitement surs d'emploi. Cet expose aura montre l'ampleur de l'effort deploye par une industrie chimique nucleaire jeune, dynamique et en plein essor. Ayant assure ses techniques, realise de nombreuses installations, elle est largement en etat de faire face au programme atomique fran is. En outre, elle est capable et desireuse d'etre associee aux developpements de l

  20. Public debate about the EPR nuclear power plant at Flamanville; Debat public sur la centrale nucleaire EPR a Flamanville

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    The project of building of he EPR reactor at Flamanville (Manche, France) has been submitted to the public debate. This document includes a presentation of the project and of the rules of the public debate, a synthesis of the file made by the prime contractor (EDF), a synthesis of the collective book of national actors concerned by the project (a group of associations for environment protection, Areva company, the ministries of economy and ecology, Global Chance, association of pro-nuclear ecologists (AEPN), 'Sortir du Nucleaire' (out-of nuclear) network, group of scientists for the information about nuclear (GSIEN), association for the promotion of the Flamanville site (Proflam), French nuclear energy society (SFEN) in association with 'Sauvons le Climat' (let's save climate), regional collective association 'EPR non merci, ni ailleurs, ni ici' (EPR, no thanks, neither elsewhere, nor here), NegaWatt), and 5 detailed books of actors: ACRO (association for the control of radioactivity in Western France), CFDT and CGT syndicates, the economic and social council of Basse Normandie region, and Proflam. (J.S.)

  1. N. 2874 Report realized for the foreign Affairs commission on the law project n. 2785 authorizing the approbation of international agreements on the civil liability in the nuclear energy domain; N. 2874 Rapport fait au nom de la commission des affaires etrangeres sur le projet de loi n. 2785 autorisant l'approbation d'accords internationaux sur la responsabilite civile dans le domaine de l'energie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This report is discussing the approval of two new protocols aiming to modify the OECD convention on the civil liability in the nuclear energy domain. After a presentation of the international regime of civil liability in the nuclear domain with the Paris and Vienna conventions, the author analyzes the main improvements offered by the two new protocols. (A.L.B.)

  2. Project of law authorizing the approval of the agreement between the government of the French republic and the government of the Russian federation relative to the civil liability by way of nuclear damage owing to the supply of materials from the French republic devoted to nuclear facilities in the Russian federation; Projet de loi autorisant l'approbation de l'accord entre le gouvernement de la republique francaise et le gouvernement de la federation de Russie relatif a la responsabilite civile au titre de dommages nucleaires du fait de fournitures en provenance de la republique francaise destinees a des installations nucleaires en federation de Russie

    Energy Technology Data Exchange (ETDEWEB)

    Raffarin, J.P.; Villepin, D. de

    2002-07-01

    An agreement between France and Russia was signed on June 20, 2000 about the civil liability of Russia because of the supply of French material devoted to Russian nuclear facilities. This agreement was necessary because Russia do not belong to any of the two big international civil liability systems relative to nuclear energy, i.e. the Paris convention from July 29, 1960 (in the OECD framework) and the Vienna convention from May 21, 1963 (in the IAEA framework). This agreement offers a protection to the French nuclear suppliers against any damage claims in the case of a nuclear accident occurring on the Russian federation territory. This project of law aims at approving this agreement. (J.S.)

  3. Decree from August 27, 1996 authorizing Electricite de France to modify in order to keep under surveillance and in an intermediate dismantling state the basic nuclear installation named Chinon A 3 (reactor definitely decommissioned) on the Chinon nuclear site of the Avoine town (Indre-et-Loire); Decret du 27 aout 1996 autorisant Electricite de France a modifier pour conserver sous surveillance dans un etat intermediaire de demantellement l`installation nucleaire de base denommee Chinon A 3 (reacteur arrete definitivement) sur le site nucleaire de Chinon de la commune d`Avoine (Indre-et-Loire)

    Energy Technology Data Exchange (ETDEWEB)

    Juppe, A. [Premier Ministre, 75 - Paris (France); Borotra, F. [Ministere de l`Industrie, de la Poste et des Telecommunications, 75 - Paris (France); Lepage, C. [Ministere de l`Environnement, 75 - Paris (France)

    1996-07-01

    This decree from the French prime minister, the minister of environment and the minister of industry and postal services gives permission to Electricite de France (EdF) to modify and keep under surveillance the partially dismantled Chinon A 3 reactor which will be renamed Chinon A 3D. The modification consist in confining the internal structures and heat exchangers inside their buildings with the plugging of all apertures. Primary and auxiliary circuits will be dismantled. The decree describes the installation and summarizes the technical rules which must be applied concerning the works schedule, the quality assurance, the confinement and protection against risks of radioactivity dissemination, the personnel and public protection against ionizing radiations, the control of environmental pollution with liquid and gaseous effluents, the reduction of volume and radioactivity of solid wastes, the transport and handling of radioactive materials, the protection against earthquakes and fire, and the personnel training. (J.S.). 20 refs.

  4. Progress report: nuclear safety and radiation protection in France in 2005; Rapport annuel: la surete nucleaire et la radioprotection en France en 2005

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The Asn (Nuclear safety authority) considers that 2005 was a satisfactory year in terms of nuclear safety and radiation protection. However, further progress can and must be made. 2005 was a year of great progress for the Asn as it consolidated its organisation and working methods, in accordance with the 2005-2007 strategic plan it set for itself. The Asn continued progress in the field of radiation protection has given rise to various new regulations to improve the legislative and regulatory framework in this area. 2005 was marked by significant progress in the process of harmonizing national nuclear safety policies Against a backdrop of the preparation of a bill on management of radioactive materials and waste, to be presented to Parliament in March 2006, 2005 was a year of important milestones. The Asn control activities encompass the following seven areas: development of general regulations for nuclear safety and radiation protection; management of individual authorization requests and receipt of declarations; inspection of nuclear activities; organisation of radiological surveillance of individuals and of the environment; preparation for management of emergency situations and implementation if necessary; contribution to public information on nuclear safety and radiation protection; determination of the French position within international community. Main topics in 2005: government bill on transparency and security in the nuclear field; the challenges and ambitions of the Asn; controlling exposure to radon; EPR Reactor Project Safety; working towards a law on radioactive waste in 2006; I.R.R.T.: an international audit of Asn in 2006; harmonization of nuclear safety in Europe; Chernobyl: what has been achieved over the past 20 years; informing the Public; internal authorizations. (N.C.)

  5. The atomic energy course of the 'Institut National des Sciences et Techniques nucleaires' at the centre d'Etudes Nucleaires at Saclay; L'enseignement de genie atomique de l'Institut national des Sciences et Techniques nucleaires au Centre d'Etudes nucleaires de Saclay

    Energy Technology Data Exchange (ETDEWEB)

    Baissas, H. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    foreign students. 8- Annexe: list of courses, practical work, pile projects drawn up by the 1957 students. (author)Fren. [French] 1- Les raisons de sa creation. L'electricite de France et l'industrie interessee par le developpement de l'Energie atomique ont demande au Commissariat a l'Energie atomique de former des ingenieurs capables d'etudier des projets de piles et de diriger leur construction. 2- Recrutement et Droits d'inscription. Les demandes d'inscription ont toujours depasse les possibilites. Cette annee, les cours sont suivis par 74 eleves permanents, dont 20 etrangers, et une centaine d'auditeurs libres. Tous les elevont deja ingenieurs ou nantis de grades universitaires eleves. Droit d'inscription: 250 000 F pour les eleves, 125 000 F pour les auditeurs. 3- Organisation de l'Enseignement. II comprend deux options: physique et chimie et dans chaque option: une centaine de conferences, une trentaine de travaux pratiques, des stages dans les services, l'etude d'un projet de reacteur par un groupe de 4 ou 5 eleves. L'ensemble occupe l'annee universitaire du 1 novembre au 14 juillet. 4- Sanction. Un examen final combinant les notes de deux epreuves theoriques, des travaux pratiques, du stage, et du projet conduit a un diplome d'ingenieur en genie atomique. Il n'est pas cree en realite de nouveaux ingenieurs; une mention nouvelle est seulement ajoutee a un diplome deja acquis. Les resultats ont toujours ete excellents. Le pourcentage des echecs est tres faible. 5- Placement des Diplomes. Ils reviennent tous dans leurs industries d'origine qui ont paye leurs salaires et les droits d'inscription en se privant de leurs services pendant les neuf mois de duree des cours. 6- Creations analogues. Un cours analogue a ete cree au Centre d'Etudes Nucleaires de Grenoble. Tandis que celui de SACLAY s'adresse plus specialement aux ingenieurs deja en fonctions, celui de Grenoble

  6. Opinion on the orientations chosen by the ASN within the frame of the preparation of projects of technical decisions related to nuclear activities requiring a declaration

    International Nuclear Information System (INIS)

    2008-12-01

    This report comments the orientations chosen by the ASN (the French Nuclear Safety Authority) on different topics: general methodology of assessment of risks related to some nuclear activities, projects of technical decisions related to some electric devices generating X rays, to the list of information attached to the declaration, and to practice conditions for a person with radioprotection capabilities, and project of decision related to radioprotection and ambient technical controls for some nuclear medical activities

  7. Water dynamics of Ser-His-Glu-Cys-Asn powder and effects of moisture absorption on its chemical properties.

    Science.gov (United States)

    Lin, Songyi; Xue, Peiyu; Yang, Shuailing; Li, Xingfang; Dong, Xiuping; Chen, Feng

    2017-08-01

    This study has elucidated moisture dynamics in the soybean peptide, Ser-His-Glu-Cys-Asn (SHECN) powder by using dynamic vapor sorption (DVS) and nuclear magnetic resonance (NMR). We also tried to investigate the effects of moisture absorption on the biological activity and chemical properties of SHECN with some effective methods such as mid-infrared (MIR) spectroscopy and gas chromatography-mass spectrometry (GC-MS). DVS results showed that the moisture absorption of SHECN could reach a maximum of 33%, and the SHECN powder after synthesis actually existed in a trihydrate state of SHECN.3H 2 O. Low-field NMR revealed that three water proportions including strong combined water, binding water and bulk water were involved in SHECN moisture absorption and absored water dominantly existed in the form of combined water. Magnetic resonance imaging (MRI) and MIR spectroscopy results indicated that moisture absorption could change the morphology and structure of SHECN. After moisture absorption at 50% and 75% relative humidity, 19 volatiles were identified by GC-MS analysis. Additionally, this study showed that a part of reductive groups in SHECN was oxidized and its antioxidant ability declined significantly (P moisture absorption. Water absorbed into SHECN powder can significantly change its microstructure and cause its activity to decrease. We must prevent SHECN from absorbing moisture during storage because the water can accelerate the oxidation of samples and promote microbial reactions. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  8. Lessons learned from events declared to the ASN related to interventional radiology and having occurred during radiation-based acts

    International Nuclear Information System (INIS)

    Lachaume, Jean-Luc

    2014-01-01

    Based on an analysis of events declared to the ASN and inspection observations performed in the field of interventional radiology, this report outlines that the majority of these events could have been avoided and that they result from a lack of culture in radiation protection, notably an unawareness of doses delivered to patients or received by practitioners, and of risks related to exposure to ionizing radiations. The report notably outlines that events are related to a lack of staff and means in the field of patient and personnel radiation protection, an underdeveloped risk management and radiation protection implementation, lacks in the management of delivered or received doses and absence of approaches of professional practice assessment, operator insufficient education, and weaknesses in the management of subcontracted operations. Recommendations are made related to needs in medical radio-physics, identification of acts and patients at risk and definition of patient follow-up modalities, the implementation of an approach of professional practice assessment, the storage of dosimetric data, the improvement of operator technical education, the control of subcontracted operations, and the anticipation of technical and organisational changes

  9. Flexible xxx-asp/asn and gly-xxx residues of equine cytochrome C in matrix-assisted laser desorption/ionization in-source decay mass spectrometry.

    Science.gov (United States)

    Takayama, Mitsuo

    2012-01-01

    The backbone flexibility of a protein has been studied from the standpoint of the susceptibility of amino acid residues to in-source decay (ISD) in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). Residues more susceptible to MALDI-ISD, namely Xxx-Asp/Asn and Gly-Xxx, were identified from the discontinuous intense peak of c'-ions originating from specific cleavage at N-Cα bonds of the backbone of equine cytochrome c. The identity of the residues susceptible to ISD was consistent with the known flexible backbone amides as estimated by hydrogen/deuterium exchange (HDX) experiments. The identity of these flexible amino acid residues (Asp, Asn, and Gly) is consistent with the fact that these residues are preferred in flexible secondary structure free from intramolecular hydrogen-bonded structures such as α-helix and β-sheet. The MALDI-ISD spectrum of equine cytochrome c gave not only intense N-terminal side c'-ions originating from N-Cα bond cleavage at Xxx-Asp/Asn and Gly-Xxx residues, but also C-terminal side complement z'-ions originating from the same cleavage sites. The present study implies that MALDI-ISD can give information about backbone flexibility of proteins, comparable with the protection factors estimated by HDX.

  10. Flexible Xxx–Asp/Asn and Gly–Xxx Residues of Equine Cytochrome c in Matrix-Assisted Laser Desorption/Ionization In-Source Decay Mass Spectrometry

    Science.gov (United States)

    Takayama, Mitsuo

    2012-01-01

    The backbone flexibility of a protein has been studied from the standpoint of the susceptibility of amino acid residues to in-source decay (ISD) in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). Residues more susceptible to MALDI-ISD, namely Xxx–Asp/Asn and Gly–Xxx, were identified from the discontinuous intense peak of c′-ions originating from specific cleavage at N–Cα bonds of the backbone of equine cytochrome c. The identity of the residues susceptible to ISD was consistent with the known flexible backbone amides as estimated by hydrogen/deuterium exchange (HDX) experiments. The identity of these flexible amino acid residues (Asp, Asn, and Gly) is consistent with the fact that these residues are preferred in flexible secondary structure free from intramolecular hydrogen-bonded structures such as α-helix and β-sheet. The MALDI-ISD spectrum of equine cytochrome c gave not only intense N-terminal side c′-ions originating from N–Cα bond cleavage at Xxx–Asp/Asn and Gly–Xxx residues, but also C-terminal side complement z′-ions originating from the same cleavage sites. The present study implies that MALDI-ISD can give information about backbone flexibility of proteins, comparable with the protection factors estimated by HDX. PMID:24349908

  11. A novel Asp121Asn mutation of myelin protein zero is associated with late-onset axonal Charcot-Marie-Tooth disease, hearing loss and pupil abnormalities

    Directory of Open Access Journals (Sweden)

    Xiaohui Duan

    2016-09-01

    Full Text Available Myelin protein zero (MPZ is a major component of compact myelin in peripheral nerves. Mutations in MPZ have been associated with different Charcot–Marie–Tooth disease (CMT phenotypes (CMT1B, CMT2I/J, CMTDI, Dejerine–Sottas syndrome, and congenital hypomyelination neuropathy. Here, we report phenotypic variability in a four-generation Chinese family with the MPZ mutation Asp121Asn. Genetic testing was performed on 9 family members and 200 controls. Clinical, electrophysiological and skeletal muscle MRI assessments were available for review in 6 family members. A novel heterozygous missense mutation, Asp121Asn, was observed in 5 affected members of the family. Unaffected relatives and 200 normal controls were without the mutation. Four of the affected members of the family displayed late-onset, predominantly axonal sensory and motor neuropathy, pupil abnormalities, and progressive sensorineural hearing loss. One young affected member presented with Argyll–Robertson pupils and diminished deep tendon reflexes in the lower limbs. The MPZ mutation Asp121Asn may be associated with late-onset axonal neuropathy, early-onset hearing loss and pupil abnormalities. Our report expands the number and phenotypic spectrum of MPZ mutations.

  12. The nuclear power stations of the French atomic energy programme (1960); Les centrales nucleaires de puissance du programme francais (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Leduc, C. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires; Roux, J.P. [Electricite de France (EDF), 75 - Paris (France)

    1960-07-01

    After recalling the entry of nuclear energy into energy production in France, the paper emphasizes the evolution of techniques applied in the designing of French nuclear power plants and describes the means employed for reducing costs per kWh of EDF2 and EDF3 compared with EDF1: the electric power per ton of uranium varies from 493 kW/t for EDF1 to 970 kW/t for EDF3. For this purpose the thermal power and electric power of units are changed respectively from 290 MWt for EDF1 to 1200 or 1600 MWt for EDF3 and from 28 to 250 MW. The results are obtained by an improvement in neutronic characteristics, developments in nuclear fuel technology, and simplification of the system of charging the reactor, whose means of maintenance are increased; the EDF2 heat-exchangers have been so designed as to increase the unit power of the elements, which will attain 9 MWt, as against 3 for EDF1. For EDF3 an advance project forecasts a thermodynamic layout with only one pressure stage. The paper ends with a description of the burst-slug detection systems, and an appendix gives a detailed comparative table of EDF1, EDF2 and EDF3 plant characteristics. (author) [French] Apres avoir rappele l'integration de l'energie nucleaire parmi les moyens de production de l'energie en France, les auteurs se penchent surtout sur l'evolution des techniques appliquees dans l'equipement des centrales nucleaires francaises et decrivent les moyens mis en oeuvre pour reduire les prix de revient du kWh d'EDF2 et d'EDF3 par rapport a EDF1: la puissance electrique par tonne d'uranium varie de 493 kW/t pour EDF1 a 970 kW/t pour EDF3. C'est dans ce but que les puissances thermiques et la puissance unitaire des groupes turbo-alternateurs passent respectivement de 290 MWt pour EDF1 a 1200 ou 1600 MWt pour EDF3 et de 82 a 250 MW. Les resultats sont obtenus par une amelioration des caracteristiques neutroniques, des progres realises sur la technologie des elements

  13. Formation and linear amplification of signals in nuclear spectroscopy; Formation et amplification lineaire des signaux en spectroscopie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Le Du, R.; Mettes, J.D. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-07-01

    The apparatus described can be associated to various detectors used in nuclear physics, either rapid - its rise time is always under 30 nanoseconds - or slow, because of its continuous connections. Its gain can be increased very progressively from 2000 to 10 by increasing the feedback factors. The maximum permissible entry voltage, without causing any increase in the dead-time is 12 volts, whatever the value of the gain. The device is fitted with two continuous exits giving signals of equal amplitude but of opposite sign (10 volt pulses followed by a 4 volt undershoot). Its controls, all accessible, make it possible to adapt the apparatus very rapidly to various measurements. It is completely transistorized and the amplifier is fitted into a RENATRAN 2/8 drawer. A gain 4 preamplifier in the same drawer makes it possible to obtain a total gain of 8000. (authors) [French] L'appareil que nous decrivons peut etre associe aux divers detecteurs utilises en physique nucleaire, rapides - son temps de montee propre est toujours inferieur a 30 ns - ou lents, du fait de ses liaisons continues. Son gain peut etre amene tres progressivement de 2000 a 10 par l'augmentation graduelle des taux de contre-reaction utilises. La tension maxima admissible a l'entree, sans augmentation anormale du temps mort, est de 12 volts quel que soit le gain. L'appareil comporte deux sorties continues, delivrant des signaux d'amplitudes egales et de signes opposes (impulsions de 10 volts suivies d'un undershoot de 4 volts). Ses reglages, tous accessibles, permettent d'adapter tres rapidement l'appareil aux diverses mesures. Entierement transistorise, l'amplificateur est monte dans un tiroir RENATRAN 2/8. Un preamplificateur de gain 4, inclus dans le meme tiroir permet de porter le gain a 8000. (auteurs)

  14. Progress report: nuclear safety and radiation protection in 2006; Rapport annuel: la surete nucleaire et la radioprotection en France en 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    For the French Nuclear Safety Authority (Asn), the year 2006 was marked by two important nuclear laws being passed, one of which brought about a major change in its status. The year was a relatively satisfactory one with regard to nuclear safety, although the picture was more contrasted concerning radiation protection: in this area, more particularly in the medical field, the overall impression of good progress is offset by the declaration of a number of radiotherapy accidents. Given the benefits expected from radiotherapy treatment by the patient suffering from cancer, the conditions in which this activity is carried out are a subject of major concern for Asn, in the light of the serious risks linked to patient over-exposure. ( some important points as follows: the law on transparency and security in the nuclear field, the law on sustainable management of radioactive materials and waste, Asn: an independent administrative authority, EPR reactor project safety, I.R.R.S.: an international audit of Asn in 2006, harmonization of nuclear safety, cancer radiotherapy, improved information of the public after the T.S.N. law, taking account of organisational and human factors). (N.C.)

  15. Biologically active and C-amidated hinnavinII-38-Asn produced from a Trx fusion construct in Escherichia coli.

    Science.gov (United States)

    Kang, Chang Soo; Son, Seung-Yeol; Bang, In Seok

    2008-12-01

    The cabbage butterfly (Artogeia rapae) antimicrobial peptide hinnavinII as a member of cecropin family is synthesized as 37 residues in size with an amidated lysine at C-terminus and shows the humoral immune response to a bacterial invasion. In this work, a synthetic gene for hinnavinII-38-Asn (HIN) with an additional amino acid asparagine residue containing amide group at C-terminus was cloned into pET-32a(+) vector to allow expression of HIN as a Trx fusion protein in Escherichia coli strain BL21 (DE3) pLysS. The resulting expression level of the fusion protein Trx-HIN could reach 15-20% of the total cell proteins and more than 70% of the target proteins were in soluble form. The fusion protein could be purified successfully by HiTrap Chelating HP column and a high yield of 15 mg purified fusion protein was obtained from 80 ml E. coli culture. Recombinant HIN was readily obtained by enterokinase cleavage of the fusion protein followed by FPLC chromatography, and 3.18 mg pure active recombinant HIN was obtained from 80 ml culture. The molecular mass of recombinant HIN determined by MALDI-TOF mass spectrometer is 4252.084 Da which matches the theoretical mass (4252.0 Da) of HIN. Comparing the antimicrobial activities of the recombinant hinnavinII with C-amidated terminus to that without an amidated C-terminus, we found that the amide of asparagine at C-terminus of hinnavinII improved its potency on certain microorganism such as E. coli, Enterobacter cloacae, Bacillus megaterium, and Staphylococcus aureus.

  16. Asp to Asn substitution at the first position of the DxD TOPRIM motif of recombinant bacterial topoisomerase I is extremely lethal to E. coli

    Science.gov (United States)

    Cheng, Bokun; Annamalai, Thirunavakkarasu; Sorokin, Elena; Abrenica, Maria; Aedo, Sandra; Tse-Dinh, Yuk-Ching

    2010-01-01

    SUMMARY The TOPRIM domain found in many nucleotidyl transferases contains a DxD motif involved in magnesium ion coordination for catalysis. Medium to high copy number plasmid clones of Yersinia pestis topoisomerase I (YpTOP) with Asp to Asn substitution at the first aspartate residue (D117N) of this motif could not be generated in Escherichia coli without second site mutation even when expression was under the control of the tightly regulated BAD promoter and suppressed by 2% glucose in the medium. Arabinose induction of a single copy YpTOP-D117N mutant gene integrated into the chromosome resulted in ~105 fold of cell killing in 2.5 h. Attempt to induce expression of the corresponding E. coli topoisomerase I mutant (EcTOP-D111N) encoded on a high copy number plasmid resulted in either loss of viability or reversion of the clone to wild-type. High copy plasmid clones of YpTOP-D119N and EcTOP-D113N with the Asn substitution at the second Asp of the TOPRIM motif could be stably maintained, but overexpression also decreased cell viability significantly. The Asp to Asn substitutions at these TOPRIM residues can selectively decrease Mg2+ binding affinity with minimal disruption of the active site geometry, leading to trapping of the covalent complex with cleaved DNA and causing bacterial cell death. The extreme sensitivity of the first TOPRIM position suggested that this might be a useful site for binding of small molecules that could act as topoisomerase poisons. PMID:19013470

  17. Design of an adenosine phosphorylase by active-site modification of murine purine nucleoside phosphorylase. Enzyme kinetics and molecular dynamics simulation of Asn-243 and Lys-244 substitutions of purine nucleoside phosphorylase.

    Science.gov (United States)

    Maynes, J T; Yam, W; Jenuth, J P; Gang Yuan, R; Litster, S A; Phipps, B M; Snyder, F F

    1999-12-01

    Our objective was to alter the substrate specificity of purine nucleoside phosphorylase such that it would catalyse the phosphorolysis of 6-aminopurine nucleosides. We modified both Asn-243 and Lys-244 in order to promote the acceptance of the C6-amino group of adenosine. The Asn-243-Asp substitution resulted in an 8-fold increase in K(m) for inosine from 58 to 484 microM and a 1000-fold decrease in k(cat)/K(m). The Asn-243-Asp construct catalysed the phosphorolysis of adenosine with a K(m) of 45 microM and a k(cat)/K(m) 8-fold that with inosine. The Lys-244-Gln construct showed only marginal reduction in k(cat)/K(m), 83% of wild type, but had no activity with adenosine. The Asn-243-Asp;Lys-244-Gln construct had a 14-fold increase in K(m) with inosine and 7-fold decrease in k(cat)/K(m) as compared to wild type. This double substitution catalysed the phosphorolysis of adenosine with a K(m) of 42 microM and a k(cat)/K(m) twice that of the single Asn-243-Asp substitution. Molecular dynamics simulation of the engineered proteins with adenine as substrate revealed favourable hydrogen bond distances between N7 of the purine ring and the Asp-243 carboxylate at 2.93 and 2.88 A, for Asn-243-Asp and the Asn-243-Asp;Lys-244-Gln constructs respectively. Simulation also supported a favourable hydrogen bond distance between the purine C6-amino group and Asp-243 at 2.83 and 2.88 A for each construct respectively. The Asn-243-Thr substitution did not yield activity with adenosine and simulation gave unfavourable hydrogen bond distances between Thr-243 and both the C6-amino group and N7 of the purine ring. The substitutions were not in the region of phosphate binding and the apparent S(0.5) for phosphate with wild type and the Asn-243-Asp enzymes were 1.35+/-0.01 and 1.84+/-0.06 mM, respectively. Both proteins exhibited positive co-operativity with phosphate giving Hill coefficients of 7.9 and 3.8 respectively.

  18. Especificação e Implementação de Templates GDMO e Tipos ASN 1 para Linguagem C++

    OpenAIRE

    Junior, Rivalino Matias; Specialski, Elizabeth Sueli; May, Karina; Ropelato, Patricia

    1996-01-01

    Este artigo descreve a especificação e implementação de regras para o mapeamento de templates GDMO (GuideUnes lor the Definition 01 Managed Objects) [1 l, além da implementação dos tipos ASN.1, em linguagem de programação C++[2l. Estas regras serao utilizadas no mapeamentotemplate - GDMO para classes (dass) em C++, linguagem utilizada em todo o projeto da Plataforma de Gerencia da Rede Local UFSC, a qual segue o modelo de gerenciamento de redes OSI.

  19. Asn563Ser polymorphism of CD31/PECAM-1 is associated with atherosclerotic cerebral infarction in a southern Han population

    Directory of Open Access Journals (Sweden)

    Song YM

    2014-12-01

    Full Text Available Yanmin Song, Qunfang Li, Lili Long, Ning Zhang, Yunhai Liu Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China Background: CD31, also called platelet endothelial cell adhesion molecule-1 (PECAM-1, is thought to play a role in the pathological mechanisms of atherosclerosis. Leu125Val polymorphism and elevated plasma levels of soluble PECAM-1 (sPECAM-1 were found to be associated with cerebral infarction. Our aim was to investigate the association between the Asn563Ser polymorphism of CD31/PECAM-1, plasma level of sPECAM-1, and the risk of atherosclerotic cerebral infarction (ACI in the southern Han population of the People’s Republic of China.Subjects and methods: A total of 147 subjects with ACI and 114 controls were enrolled in the study. The Asn563Ser CD31/PECAM-1 polymorphism was detected using the polymerase chain reaction–restriction fragment length polymorphism method. The plasma spECAM-1 level was measured using the enzyme-linked immunosorbent assay method.Results: In this study, statistically significant differences in Asn563Ser genotype and allele distribution were found between the cases and controls (P<0.05. Furthermore, logistic regression analysis showed that the GG genotype is associated with increase in ACI risk (odds ratio =4.862, P<0.001. The plasma level of sPECAM-1 was associated with ACI (odds ratio =1.431, P=0.038. In both the ACI and the control groups, the plasma sPECAM-1 level in subjects with the GG genotype was higher than that in subjects carrying the AA or GA genotype (P<0.05.Conclusion: Our study showed that the Asn563Ser polymorphism of CD31/PECAM-1 gene and elevated plasma sPECAM-1 level are related to ACI risk in the southern Han population of People’s Republic of China. Keywords: genetic polymorphism, CD31, platelet endothelial cell adhesion molecule-1 (PECAM-1

  20. Dynamic Study on the 400 kV 60 km Kyndbyværket – Asnæsværket Line

    DEFF Research Database (Denmark)

    Ohno, Teruo

    systems have shown to be satisfactory. The applications of HVAC cable systems are proposed more often for transmission projects, and recently proposed HVAC underground cable systems are longer compared to existing cable systems. Due to this historical background, HVAC underground cable systems have been...... lines. The PhD project focuses on the 400 kV 60 km Kyndbyværket – Asnæsværket line, which will feed power to Copenhagen, the Danish capital. The PhD project addresses major problems and potential countermeasures related to the installation and operation of a long cable line, through: (1) Insulation...

  1. A New Ala-122-Asn Amino Acid Change Confers Decreased Fitness to ALS-Resistant Echinochloa crus-galli.

    Science.gov (United States)

    Panozzo, Silvia; Scarabel, Laura; Rosan, Valentina; Sattin, Maurizio

    2017-01-01

    Gene mutations conferring herbicide resistance may cause pleiotropic effects on plant fitness. Knowledge of these effects is important for managing the evolution of herbicide-resistant weeds. An Echinochloa crus-galli population resistant to acetolactate synthase (ALS) herbicides was collected in a maize field in north-eastern Italy and the cross-resistance pattern, resistance mechanism and fitness costs associated to mutant-resistant plants under field conditions in the presence or absence of intra-specific competition were determined. The study reports for the first time the Ala-122-Asn amino-acid change in the ALS gene that confers high levels of cross-resistance to all ALS inhibitors tested. Results of 3-year growth analysis showed that mutant resistant E. crus-galli plants had a delayed development in comparison with susceptible plants and this was registered in both competitive (3, 7, and 20 plants m -2 ) and non-competitive (spaced plants) situations. The number of panicles produced by resistant plants was also lower (about 40% fewer panicles) than susceptible plants under no-intraspecific competition. Instead, with the increasing competition level, the difference in panicle production at harvest time decreased until it became negligible at 20 plants m -2 . Evaluation of total dry biomass as well as biomass allocation in vegetative parts did not highlight any difference between resistant and susceptible plants. Instead, panicle dry weight was higher in susceptible plants indicating that they allocated more biomass than resistant ones to the reproductive organs, especially in no-competition and in competition situations at lower plant densities. The different fitness between resistant and susceptible phenotypes suggests that keeping the infestation density as low as possible can increase the reproduction success of the susceptible phenotype and therefore contribute to lowering the ratio between resistant and susceptible alleles. If adequately embedded in a

  2. A New Ala-122-Asn Amino Acid Change Confers Decreased Fitness to ALS-Resistant Echinochloa crus-galli

    Directory of Open Access Journals (Sweden)

    Silvia Panozzo

    2017-11-01

    Full Text Available Gene mutations conferring herbicide resistance may cause pleiotropic effects on plant fitness. Knowledge of these effects is important for managing the evolution of herbicide-resistant weeds. An Echinochloa crus-galli population resistant to acetolactate synthase (ALS herbicides was collected in a maize field in north-eastern Italy and the cross-resistance pattern, resistance mechanism and fitness costs associated to mutant-resistant plants under field conditions in the presence or absence of intra-specific competition were determined. The study reports for the first time the Ala-122-Asn amino-acid change in the ALS gene that confers high levels of cross-resistance to all ALS inhibitors tested. Results of 3-year growth analysis showed that mutant resistant E. crus-galli plants had a delayed development in comparison with susceptible plants and this was registered in both competitive (3, 7, and 20 plants m-2 and non-competitive (spaced plants situations. The number of panicles produced by resistant plants was also lower (about 40% fewer panicles than susceptible plants under no-intraspecific competition. Instead, with the increasing competition level, the difference in panicle production at harvest time decreased until it became negligible at 20 plants m-2. Evaluation of total dry biomass as well as biomass allocation in vegetative parts did not highlight any difference between resistant and susceptible plants. Instead, panicle dry weight was higher in susceptible plants indicating that they allocated more biomass than resistant ones to the reproductive organs, especially in no-competition and in competition situations at lower plant densities. The different fitness between resistant and susceptible phenotypes suggests that keeping the infestation density as low as possible can increase the reproduction success of the susceptible phenotype and therefore contribute to lowering the ratio between resistant and susceptible alleles. If adequately

  3. Heterozygous p.Asp50Asn mutation in the GJB2 gene in two Cameroonian patients with keratitis-ichthyosis-deafness (KID) syndrome.

    Science.gov (United States)

    Wonkam, Ambroise; Noubiap, Jean Jacques N; Bosch, Jason; Dandara, Collet; Toure, Geneviève Bengono

    2013-08-07

    Keratitis-Ichthyosis-Deafness (KID) syndrome (OMIM 148210) is a congenital ectodermal defect that consists of an atypical ichthyosiform erythroderma associated with congenital sensorineural deafness. KID appears to be genetically heterogeneous and most cases are caused by GJB2 mutations. Mutations in African patients have been rarely described. We report on two unrelated Cameroonian individuals affected with sporadic KID, presenting with the classic phenotypic triad. The two patients were heterozygous for the most frequent p.Asp50Asn mutation. This first report in patients from sub-Saharan African origin supports the hypothesis that the occurrence of KID due to p.Asp50Asn mutation in GJB2 seems not to be population specific. Our finding has implication in medical genetic practice, specifically in the molecular diagnosis of KID in Africans. These cases also reveal and emphasize the urgent need to develop appropriate policies to care for patients with rare/orphan diseases in Sub-Saharan Africa, as many of these cases become more and more recognizable.

  4. Association between RABV G Proteins Transported from the Perinuclear Space to the Cell Surface Membrane and N-Glycosylation of the Sequon Asn(204).

    Science.gov (United States)

    Hamamoto, Noriko; Uda, Akihiko; Tobiume, Minoru; Park, Chun-Ho; Noguchi, Akira; Kaku, Yoshihiro; Okutani, Akiko; Morikawa, Shigeru; Inoue, Satoshi

    2015-01-01

    In this study, G proteins of the rabies virus (RABV) Kyoto strain were detected in the cytoplasm but not distributed at the cell membrane of mouse neuroblastoma (MNA) cells. G proteins of CVS-26 were detected in both the cell membrane and perinuclear space of MNA cells. We found that N-glycosylation of street RABV G protein by the insertion of the sequon Asn(204) induced the transfer of RABV G proteins to the cell surface membrane. Fixed RABV budding from the plasma membrane has been found to depend not only on G protein but also on other structural proteins such as M protein. However, the differing N-glycosylation of G protein could be associated with the distinct budding and antigenic features of RABV in street and fixed viruses. Our study of the association of N-glycan of G protein at Asn(204) with the transport of RABV G protein to the cell surface membrane contributes to the understanding of the evolution of fixed virus from street virus, which in turn would help for determine the mechanism underlying RABV budding and enhanced host immune responses.

  5. Deletion of Asn{sup 281} in the {alpha}-subunit of the human insulin receptor causes constitutive activation of the receptor and insulin desensitization

    Energy Technology Data Exchange (ETDEWEB)

    Desbois-Mouthon, C.; Sert-Langeron, C.; Magre, J.; Blivet, M.J. [INSERM, Paris (France)] [and others

    1996-02-01

    We studied the structure and function of the insulin receptor (IR) in two sisters with leprechaunism. The patients had inherited alterations in the IR gene and were compound heterozygotes. Their paternal IR allele carried a major deletion, including exons 10-13, which shifted the reading frame and introduced a premature chain termination codon in the IR sequence. This allele was expressed at a very low level in cultured fibroblasts (<10% of total IR messenger ribonucleic acid content) and encoded a truncated protein lacking transmembrane and tyrosine kinase domains. The maternal IR allele was deleted of 3 bp in exon 3, causing the loss of Asn{sup 281} in the {alpha}-subunit. This allele generated levels of IR messenger ribonucleic acid and cell surface receptors similar to those seen in control fibroblasts. However, IRs from patients` cells had impaired insulin binding and exhibited in vivo and in vitro constitutive activation of autophosphorylation and tyrosine kinase activity. As a result of this IR-preactivated state, the cells were desensitized to insulin stimulation of glycogen and DNA syntheses. These findings strongly suggest that Asn{sup 281} of the IR {alpha}-subunit plays a critical role in the inhibitory constraint exerted by the extracellular {alpha}-subunit over the intracellular kinase activity. 59 refs., 6 figs.

  6. Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation.

    Science.gov (United States)

    Stamenkovic, Miroslav; Radic, Tanja; Stefanovic, Ivan; Coric, Vesna; Sencanic, Ivan; Pljesa-Ercegovac, Marija; Matic, Marija; Jaksic, Vesna; Simic, Tatjana; Savic-Radojevic, Ana

    2014-04-01

    Glutathione S-transferase omega-1 and 2 have a unique range of enzymatic activities, including the regeneration of ascorbate by their dehydroascorbate reductase activities. Because these enzymes could have a protective role from oxidative damage in the lens, the question of whether the two coding glutathione S-transferase omega polymorphisms confer the risk of age-related cataract was addressed. rs4925 (Ala140Asp) of glutathione S-transferase omega-1 and rs156697 (Asn142Asp) of glutathione S-transferase omega-2 polymorphisms in 100 patients with age-related cataract and 130 controls were assessed. Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086). When GSTO genotype was analysed in association with smoking or professional exposure to ultraviolet irradiation, carriers of at least one mutant GSTO2*Asp allele had increased risk of cataract development in comparison with individuals with wild-type GSTO2*Asn/Asn with no history of smoking or ultraviolet exposure (odds ratio = 6.89, 95% confidence interval = 1.81-16.21, P = 0.005; odds ratio = 4.10, 95% confidence interval = 1.23-13.74, P = 0.022, respectively). Regarding the distribution of particular glutathione S-transferase omega genotype and cataract type, the highest frequency of mutant GSTO2*Asp allele was found in patients with nuclear cataract. The results indicate that mutant GSTO2*Asp genotype is associated with increased risk of age-related cataract in smokers and ultraviolet-exposed subjects, suggesting a role of inefficient ascorbate regeneration in cataract development. © 2013 Royal Australian and New Zealand College of Ophthalmologists.

  7. Regulation Mechanism of the ald Gene Encoding Alanine Dehydrogenase in Mycobacterium smegmatis and Mycobacterium tuberculosis by the Lrp/AsnC Family Regulator AldR.

    Science.gov (United States)

    Jeong, Ji-A; Hyun, Jaekyung; Oh, Jeong-Il

    2015-10-01

    In the presence of alanine, AldR, which belongs to the Lrp/AsnC family of transcriptional regulators and regulates ald encoding alanine dehydrogenase in Mycobacterium smegmatis, changes its quaternary structure from a homodimer to an octamer with an open-ring conformation. Four AldR-binding sites (O2, O1, O4, and O3) with a consensus sequence of GA/T-N2-NWW/WWN-N2-A/TC were identified upstream of the M. smegmatis ald gene by means of DNase I footprinting analysis. O2, O1, and O4 are required for the induction of ald expression by alanine, while O3 is directly involved in the repression of ald expression. In addition to O3, both O1 and O4 are also necessary for full repression of ald expression in the absence of alanine, due to cooperative binding of AldR dimers to O1, O4, and O3. Binding of a molecule of the AldR octamer to the ald control region was demonstrated to require two AldR-binding sites separated by three helical turns between their centers and one additional binding site that is in phase with the two AldR-binding sites. The cooperative binding of AldR dimers to DNA requires three AldR-binding sites that are aligned with a periodicity of three helical turns. The aldR gene is negatively autoregulated independently of alanine. Comparative analysis of ald expression of M. smegmatis and Mycobacterium tuberculosis in conjunction with sequence analysis of both ald control regions led us to suggest that the expression of the ald genes in both mycobacterial species is regulated by the same mechanism. In mycobacteria, alanine dehydrogenase (Ald) is the enzyme required both to utilize alanine as a nitrogen source and to grow under hypoxic conditions by maintaining the redox state of the NADH/NAD(+) pool. Expression of the ald gene was reported to be regulated by the AldR regulator that belongs to the Lrp/AsnC (feast/famine) family, but the underlying mechanism was unknown. This study revealed the regulation mechanism of ald in Mycobacterium smegmatis and

  8. Association of Natural Killer Cell Ligand Polymorphism HLA-C Asn80Lys With the Development of Anti-SSA/Ro-Associated Congenital Heart Block.

    Science.gov (United States)

    Ainsworth, Hannah C; Marion, Miranda C; Bertero, Tiziana; Brucato, Antonio; Cimaz, Rolando; Costedoat-Chalumeau, Nathalie; Fredi, Micaela; Gaffney, Patrick; Kelly, Jennifer; Levesque, Kateri; Maltret, Alice; Morel, Nathalie; Ramoni, Veronique; Ruffatti, Amelia; Langefeld, Carl D; Buyon, Jill P; Clancy, Robert M

    2017-11-01

    Fetal exposure to maternal anti-SSA/Ro antibodies is necessary but not sufficient for the development of autoimmune congenital heart block (CHB), suggesting that other factors, such as fetal genetic predisposition, are important. Given the previously described association between major histocompatibility complex alleles and CHB risk, we undertook the present study to test the hypothesis that a variant form of HLA-C Asn80Lys, which binds with high affinity to an inhibitory killer cell immunoglobulin-like receptor (KIR) and thus renders natural killer (NK) cells incapable of restricting inflammation, contributes to the development of CHB. Members of 192 pedigrees in the US and Europe (194 cases of CHB, 91 unaffected siblings, 152 fathers, 167 mothers) and 1,073 out-of-study controls were genotyped on the Immunochip single-nucleotide polymorphism microarray. Imputation was used to identify associations at HLA-C Asn80Lys (Asn, C1; Lys, C2) and KIR. Tests for association were performed using logistic regression. McNemar's test and the pedigree disequilibrium test (PDT) were used for matched analyses between affected and unaffected children. Compared with out-of-study controls of the same sex, the C2 allele was less frequent in the mothers (odds ratio [OR] 0.63, P = 0.0014) and more frequent in the fathers (OR 1.40, P = 0.0123), yielding a significant sex-by-C2 interaction (P = 0.0002). The C2 allele was more frequent in affected siblings than in unaffected siblings (OR 3.67, P = 0.0025), which was consistent with the PDT results (P = 0.016); these results were observed in both sexes and across the US and European cohorts. There was no difference in the frequency of the inhibitory KIR genotype (KIR AA) between affected and unaffected children (P = 0.55). These data establish C2 as a novel genetic risk factor associated with CHB. This observation supports a model in which fetuses with C2 ligand expression and maternal anti-SSA/Ro positivity may have impaired NK cell

  9. Improving radiotherapy quality and safety: a common objective of A.S.N. and the Ile de France Regional Hospital Agency. Thoughts on successful cooperation in Ile de France

    International Nuclear Information System (INIS)

    Solier, N.

    2009-01-01

    Radiotherapy recent development in cancer treatment needs strong procedures and quality assessment to improve safety both for patients and professionals. In Ile de France territory, a coordinated action between ASN inspectors and medical doctors specialized in public health (MISP), working as civil servants in health administration, was initiated at the end of 2007. An inspection guideline was implemented in a workshop between ASN and Regional Hospital Agency (ARH). The MISP as health administrator has to verify if care organisation responds to treatment cancer regulatory framework: as a doctor he is authorized to access to patient records to know which treatment was chosen. He has to assure if the therapeutic guidelines are respected. His comprehensive approach is essentially patient-oriented. The MISP inspection coordinated with ASN inspectors is a very pertinent pluri-disciplinary approach, undeniably necessary in such a medical technic. The effectiveness of the radiotherapy pluri-disciplinary team is funded on sharing procedures and experiences, respecting different knowledge and practices in daily work. This on site audit'. seems to be very fertile both for the radiotherapy team, the MISP and ASN inspectors. Continuous quality improvement in radiotherapy in the Ile de France region is a fertile issue between ANS and ARH teams. Confronting knowledge and procedures during the 'on site audit' in a transparent way will contribute improving radiotherapy for the 30.000 Francilian patients which receive this treatment each year. This challenge is our main concern to facilitate the patients access to the best standards treatments. (author)

  10. Role of the conserved amino acids of the 'SDN' loop (Ser130, Asp131 and Asn132) in a class A beta-lactamase studied by site-directed mutagenesis.

    Science.gov (United States)

    Jacob, F; Joris, B; Lepage, S; Dusart, J; Frère, J M

    1990-10-15

    Ser130, Asp131 and Asn132 ('SDN') are highly conserved residues in class A beta-lactamases forming one wall of the active-site cavity. All three residues of the SDN loop in Streptomyces albus G beta-lactamase were modified by site-directed mutagenesis. The mutant proteins were expressed in Streptomyces lividans, purified from culture supernatants and their kinetic parameters were determined for several substrates. Ser130 was substituted by Asn, Ala and Gly. The first modification yielded an almost totally inactive protein, whereas the smaller-side-chain mutants (A and G) retained some activity, but were less stable than the wild-type enzyme. Ser130 might thus be involved in maintaining the structure of the active-site cavity. Mutations of Asp131 into Glu and Gly proved to be highly detrimental to enzyme stability, reflecting significant structural perturbations. Mutation of Asn132 into Ala resulted in a dramatically decreased enzymic activity (more than 100-fold) especially toward cephalosporin substrates, kcat. being the most affected parameter, which would indicate a role of Asn132 in transition-state stabilization rather than in ground-state binding. Comparison of the N132A and the previously described N132S mutant enzymes underline the importance of an H-bond-forming residue at position 132 for the catalytic process.

  11. Is it possible to recycle nuclear wastes? Costs, risks and stakes of the plutonium industry; Peut-on recycler les dechets nucleaires? Couts, risques et enjeux de l'industrie du plutonium

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    This document, published by the French association 'Sortir du nucleaire' (Get out of nuclear), gives some information on the chain reaction from uranium to plutonium, the difference between reprocessing (which does not reduce waste volumes but multiply waste types) and recycling, the high risks associated with plutonium transport, La Hague as the most dangerous nuclear site in France, reprocessing as the alibi for the French nuclear industry, Areva as an expert in propaganda, reprocessing as an absurd world strategy, plutonium as a fuel for proliferation, the myth of unlimited energy with the breeder reactors, and so on

  12. Substrate recognition and catalysis by GH47 α-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway

    Energy Technology Data Exchange (ETDEWEB)

    Xiang, Yong; Karaveg, Khanita; Moremen, Kelley W.

    2016-11-17

    Asn-linked glycosylation of newly synthesized polypeptides occurs in the endoplasmic reticulum of eukaryotic cells. Glycan structures are trimmed and remodeled as they transit the secretory pathway, and processing intermediates play various roles as ligands for folding chaperones and signals for quality control and intracellular transport. Key steps for the generation of these trimmed intermediates are catalyzed by glycoside hydrolase family 47 (GH47) α-mannosidases that selectively cleave α1,2-linked mannose residues. Despite the sequence and structural similarities among the GH47 enzymes, the molecular basis for residue-specific cleavage remains obscure. The present studies reveal enzyme–substrate complex structures for two related GH47 α-mannosidases and provide insights into how these enzymes recognize the same substrates differently and catalyze the complementary glycan trimming reactions necessary for glycan maturation.

  13. Hematological and Molecular Characterization of Hb J-Buda [α61(E10)Lys → Asn, AAG > AAT].

    Science.gov (United States)

    Panyasai, Sitthichai; Permsripong, Nopphadol; Jaiping, Kanokwan; Khantarag, Pisuttinee; Pornprasert, Sakorn

    2016-06-01

    Hemoglobin (Hb) J-Buda [α61(E10)Lys → Asn, AAG > AAT] is a very rare α-chain variant found in South-East Asia. We analyzed hematological parameters and provided a rapid molecular analysis method for detection of this hemoglobinopathy in two Thai women who had severe microcytic anemia with Hb and MCV AAG → AAT mutation at codon 61 for Hb J-Buda on one allele of the α1-globin gene. The developed Allele-specific PCR (ASPCR) showed the 455 bp amplified fragment from Hb J-Buda allele. Thus, understanding of hematological characterizations and the developed ASPCR for diagnosis of Hb J-Buda are essential for genetic counseling of this hemoglobinopathy.

  14. Control of doses delivered to patients in medical imagery. Progress report of the program of actions recommended by the ASN. January 2015

    International Nuclear Information System (INIS)

    2015-01-01

    This report proposes an overview and an assessment of the various actions recommended by the ASN (the French Nuclear Safety Authority) for a better management of doses delivered to patients in the case of medical imagery. It indicates and discusses the progress noticed: actions which have been already performed, actions which are currently in progress, and actions which are still to be launched. These actions concern various aspects: the practice quality and safety (quality and safety management), the organisation, human resources and training, equipment and installation safety, radio-vigilance practices, relationships with patients, knowledge of practices and of exposures of patients and workers. Some highlights are outlined: some persistent lacks in human resources, some encouraging initiatives in the field of training, some progresses in the field of practice quality and safety, and some limited results regarding equipment (notably MRI) and installation safety

  15. Thermal energy of nuclear origin produced in non-fissile materials (1962); Energie calorifique d'origine nucleaire degagee dans les materiaux non fissiles (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Naudet, G. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Millies, P.; Berger, J. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1962-07-01

    A first part is devoted to the description of the interaction phenomena between elementary particles and material that may be observed during the irradiation process in a nuclear reactor: nuclear reactions due to neutrons, production of gamma rays and absorption of those gamma rays through various processes. In a second part the phenomena producing calorific energy in irradiated material are quantitatively examined. In the third part results are summed up in a formulary. The fourth part presents tables and figures giving to the reader all the numerical values necessary for practical calculations. (authors) [French] Une premiere partie est consacree a l'examen des principaux phenomenes d'interaction des particules avec la matiere qui interviennent lors d'une irradiation dans un reacteur: reactions nucleaires dues aux neutrons, production des rayons gamma et absorption de ces derniers par les divers processus. Une deuxieme partie etudie quantitativement les phenomenes qui conduisent a l'apparition d'energie calorifique dans le materiau irradie. En troisieme partie, un formulaire resume les resultats etablis. Dans une quatrieme partie, des tableaux et des courbes fournissent a l'experimentateur toutes les valeurs numeriques necessaires aux calculs pratiques. (auteurs)

  16. Annual report ''nuclear safety in France''; Le rapport annuel ''la surete nucleaire en France''

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    This document is the 2001 annual report of the French authority of nuclear safety (ASN). It summarizes the highlights of the year 2000 and details the following aspects: the nuclear safety in France, the organization of the control of nuclear safety, the regulation relative to basic nuclear facilities, the control of facilities, the information of the public, the international relations, the organisation of emergencies, the radiation protection, the transport of radioactive materials, the radioactive wastes, the PWR reactors, the experimental reactors and other laboratories and facilities, the nuclear fuel cycle facilities, and the shutdown and dismantling of nuclear facilities. (J.S.)

  17. Summary of the report A.S.N. n. 2006 ENSTR 019 - IGAS n. RM 2007-015P on the Epinal radiotherapy accident

    International Nuclear Information System (INIS)

    2007-01-01

    The Nuclear Safety Authority (A.S.N.) and the General Inspection of Social Affairs (I.G.A.S.) have been in charge by the Ministry of an inquiry on the accident that has lead to the overdose of 23 patients irradiated for a prostate cancer at the Hospital of Epinal. This event constitutes the most important accident implying the ionizing radiations occurring in France. In may 2004, the protocol of conformal radiotherapy applied to the prostate cancers has been modified, it uses dynamics corners in place of static corners. This change supposes to modify the parameters definition that gives the calculation of irradiation intensity, that will not not be made for some of patients. This mistake could be changed if the in vivo dosimetry that allows to check the real dose received by the patients had been kept. but this line of safety has been removed, the use of dynamic corners making it ineffective. The period of over irradiation has been from the 6. may 2004 to the 1. august 2005. During the summer 2005, the radiotherapist and radio physicist find the overdose error by examining the patients files again. On the 15. september 2005, the two doctors of the service warn the director of the C.H.J.M. (hospital center of Jean Monnet) of the accident that informs D.D.A.S.S. (departmental direction of sanitary and social affairs) and A.R.H. (regional agencies of hospitalization). But the national authorities (A.F.S.S.A.P.S., A.S.N., I.R.S.N.) have not been warned, and so nobody can recognize the unsuitable character of the decided measures. Only seven patients are informed of the overdose of radiations they received during the last trimester 2005. The assistance to the victims is not organised the first year. All the patients have received usual treatments when they should receive a treatment by graft of mesenchymatous stem cells. Between september 2005 and september 2006 four patients died and ten present serious complications. propositions have been made to help the victims and

  18. Nuclear wastes; Dechets nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    Here is made a general survey of the situation relative to radioactive wastes. The different kinds of radioactive wastes and the different way to store them are detailed. A comparative evaluation of the situation in France and in the world is made. The case of transport of radioactive wastes is tackled. (N.C.)

  19. Nuclear energy; Le nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This digest document was written by members of the union of associations of ex-members and retired people of the Areva group (UARGA). It gives a comprehensive overview of the nuclear industry world, starting from radioactivity and its applications, and going on with the fuel cycle (front-end, back-end, fuel reprocessing, transports), the nuclear reactors (PWR, BWR, Candu, HTR, generation 4 systems), the effluents from nuclear facilities, the nuclear wastes (processing, disposal), and the management and safety of nuclear activities. (J.S.)

  20. Elimination of effluents and wastes contaminated by radionuclides produced in installations authorized on the account of the Public Health Code - ASN guide nr 18 - Release of the 26/01/2012

    International Nuclear Information System (INIS)

    2012-01-01

    This document aims at specifying the modalities of application of a decision taken by the ASN in January 2008 regarding the technical rules which the elimination of effluents and wastes contaminated by radionuclides must comply with. First, it describes the objective of the 'waste zoning' concept. Then, it addresses the management of contaminated wastes: general rules, wastes contaminated by radionuclides of very short period (less than 100 days) and of period longer than 100 days, and the management of wastes with 'hybrid risks'. It addresses the management of contaminated effluents: radioactive liquid effluent with a period either shorter or longer than 100 days, radioactive gaseous effluents. It addresses the warehousing conditions (premise design, exploitation rules). The other parts deal with the convention between several establishments within a same site (notably in the case of nuclear medicine departments), with the management plan, and with the agenda for the implementation of the ASN decision

  1. "Minulost je bitevním polem současníků". Konference k osmdesátinám Viléma Prečana

    Czech Academy of Sciences Publication Activity Database

    Hoppe, Jiří

    2013-01-01

    Roč. 20, 1/2 (2013), s. 236-241 ISSN 1210-7050. ["Minulost je bitevním polem současníků". Konference k osmdesátinám Viléma Prečana. Praha, 24.01.2013-25.01.2013] Institutional support: RVO:68378114 Keywords : Vilém Prečan Subject RIV: AB - History

  2. Celostátní seminář Celoživotní učení - Kroměříž 2006 "Současná realita - budoucnost".

    Czech Academy of Sciences Publication Activity Database

    Basl, Josef

    2006-01-01

    Roč. 10, č. 6 (2006) ISSN 1212-5075. [Celoživotní učení - Kroměříž 2006 "Současná realita - budoucnost". Kroměříž, 18.05.2006-19.05.2006] R&D Projects: GA ČR GA403/06/1421 Institutional research plan: CEZ:AV0Z70280505 Keywords : Czech Republic * lifelong learning * current issues Subject RIV: AO - Sociology, Demography

  3. [Hb Burgos (α1 CD64(E13)(Asp→Asn)): a new hemoglobin variant detected during follow-up of diabetic patients].

    Science.gov (United States)

    de la Fuente-Gonzalo, Félix; Martínez Nieto, Jorge; Torrejón, María José; Mayor, Luis Antonio; Velasco, Diego; González Fernández, Fernando Ataulfo; Ropero Gradilla, Paloma

    2015-01-06

    The glycated hemoglobin (HbA1c) test by high performance liquid chromatography is a useful tool for the follow-up of diabetes mellitus patients. Some structural hemoglobin (Hb) variants are known to cause interference in the analytical measurement of HbA1c. In this study, it has been characterized a new Hb variant in 4 patients during their regular control of HbA1c. Selective α1 gene sequencing showed a mutation GAC>AAC at codon 64 within exon 2. This produces a change of aspartic acid (Asp) by asparagine (Asn) that does not produce any functional alteration so the resultant molecule behaves as a silent hemoglobinopathy. The structural Hb variants can be detected during the analysis of HbA1c and may alter its values. Though rare, this occurrence signals the need to being aware when measuring HbA1c. Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

  4. Identification of homozygous WFS1 mutations (p.Asp211Asn, p.Gln486*) causing severe Wolfram syndrome and first report of male fertility

    Science.gov (United States)

    Haghighi, Amirreza; Haghighi, Alireza; Setoodeh, Aria; Saleh-Gohari, Nasrollah; Astuti, Dewi; Barrett, Timothy G

    2013-01-01

    Wolfram syndrome (WFS) is a neurodegenerative genetic condition characterized by juvenile-onset of diabetes mellitus and optic atrophy. We studied clinical features and the molecular basis of severe WFS (neurodegenerative complications) in two consanguineous families from Iran. A clinical and molecular genetic investigation was performed in the affected and healthy members of two families. The clinical diagnosis of WFS was confirmed by the existence of diabetes mellitus and optic atrophy in the affected patients, who in addition had severe neurodegenerative complications. Sequencing of WFS1 was undertaken in one affected member from each family. Targeted mutations were tested in all members of relevant families. Patients had most of the reported features of WFS. Two affected males in the first family had fathered unaffected children. We identified two homozygous mutations previously reported with apparently milder phenotypes: family 1: c.631G>A (p.Asp211Asn) in exon 5, and family 2: c.1456C>T (p.Gln486*) in exon 8. Heterozygous carriers were unaffected. This is the first report of male Wolfram patients who have successfully fathered children. Surprisingly, they also had almost all the complications associated with WFS. Our report has implications for genetic counseling and family planning advice for other affected families. PMID:22781099

  5. Identification of homozygous WFS1 mutations (p.Asp211Asn, p.Gln486*) causing severe Wolfram syndrome and first report of male fertility.

    Science.gov (United States)

    Haghighi, Amirreza; Haghighi, Alireza; Setoodeh, Aria; Saleh-Gohari, Nasrollah; Astuti, Dewi; Barrett, Timothy G

    2013-03-01

    Wolfram syndrome (WFS) is a neurodegenerative genetic condition characterized by juvenile-onset of diabetes mellitus and optic atrophy. We studied clinical features and the molecular basis of severe WFS (neurodegenerative complications) in two consanguineous families from Iran. A clinical and molecular genetic investigation was performed in the affected and healthy members of two families. The clinical diagnosis of WFS was confirmed by the existence of diabetes mellitus and optic atrophy in the affected patients, who in addition had severe neurodegenerative complications. Sequencing of WFS1 was undertaken in one affected member from each family. Targeted mutations were tested in all members of relevant families. Patients had most of the reported features of WFS. Two affected males in the first family had fathered unaffected children. We identified two homozygous mutations previously reported with apparently milder phenotypes: family 1: c.631G>A (p.Asp211Asn) in exon 5, and family 2: c.1456C>T (p.Gln486*) in exon 8. Heterozygous carriers were unaffected. This is the first report of male Wolfram patients who have successfully fathered children. Surprisingly, they also had almost all the complications associated with WFS. Our report has implications for genetic counseling and family planning advice for other affected families.

  6. New features of nuclear excitation by {alpha} particles scattering; Nouveaux aspects de l'excitation nucleaire par diffusion de particules {alpha}

    Energy Technology Data Exchange (ETDEWEB)

    Saudinos, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1962-07-01

    Inelastic scattering of medium energy a particles by nuclei is known to excite preferentially levels of collective character. We have studied the scattering of isotopically enriched targets of Ca, Fe, Ni, Cu, Zn. In part I, we discuss the theoretical features of the interaction. In part II, we describe the experimental procedure. Results are presented and analysed in part III. {alpha} particles scattering by Ca{sup 40} is showed to excite preferentially odd parity levels. In odd nuclei we have observed multiplets due to the coupling of the odd nucleon with the even-even core vibrations. For even-even nuclei, a few levels are excited with lower cross-sections between the well-known first 2{sup +} and 3{sup -} states. Some could be members of the two phonon quadrupole excitation and involve a double nuclear excitation process. (author) [French] On sait que la diffusion inelastique des particules alpha de moyenne energie excite preferentiellement des niveaux de caractere collectif. Nous avons etudie la diffusion des particules alpha de 44 MeV du cyclotron de Saclay par des isotopes separes de Ca, Fe, Ni, Cu, Zn. Dans la premiere partie nous exposons les theories de cette interaction. Dans la seconde nous decrivons le systeme experimental. Les resultats sont donnes dans la troisieme partie. Nous montrons que les niveaux excites preferentiellement pour {sup 40}Ca par diffusion ({alpha},{alpha}') sont de parite negative. Dans les noyaux pair-impair nous avons observe des multiplets dus au couplage du nucleon celibataire avec les vibrations du coeur pair-pair. Pour les noyaux pair-pair nous avons pu etudier entre le premier niveau 2{sup +} et le niveau 3{sup -} deja bien connus certains etats plus faiblement excites. Il semble qu'ils sont dus a une excitation quadrupolaire a deux phonons et impliquent un processus de double excitation nucleaire. (auteur)

  7. Actions of the French Nuclear Safety Authority in response to the growth in public demand for environmental transparency; Les actions de l'ASN pour repondre a l'evolution de la demande du public en matiere de transparence environnementale

    Energy Technology Data Exchange (ETDEWEB)

    Clipet, N. [Autorite de Surete Nucleaire, Direction de la communication et de l' information des publics, 75 - Paris (France)

    2010-06-15

    The Nuclear Transparency and Security Act 2006-686 of 13 June 2006 (TSN Act) reinforces the integrated approach to nuclear safety, radiation protection and environmental concerns. The TSN Act guarantees 'the public's right to reliable and accessible information on nuclear security' (Article 1). ASN fosters the implementation of this information right. Concerning the environment, it ensures that the available information is accessible and shared. This concern applies first to its own information media and actions, but also to the stakeholders. ASN makes sure that the licensees fulfill the transparency duty required by the TSN Act and is watchful concerning the effectiveness of means implemented for the public access to information. ASN also promotes good practices in its annual report for the public information. With regard to the environment, ASN actions are primarily focused on limiting and supervising the effluents discharges resulting from nuclear activities; monitoring radioactivity in the environment; and preventing and managing emergency situations. One of the recent significant contributions to providing the public with reliable, centralized information is the launch of www.mesure-radioactivite.fr. This web-site issued by the national network under the aegis of ASN, gives the public access to the results of radioactivity measurements carried out by certified laboratories. ASN seeks to involve the public in projects with an important impact on the environment. It considers the Local Information Committees (CLI) as an important contributor to the 'ecological democracy' and invites periodically their representatives to take part in ASN inspections. ASN also encourages public debates. Besides, this is one of the axis of its strategic plan 2010-2012. (author)

  8. Health problems raised by the elimination of radioactive wastes and nuclear accidents; Problemes sanitaires poses par l'elimination des dechets radioactifs et par les accidents nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Jammet, H.; Mechali, D.; Dousset, M. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1964-07-01

    The rapid development of nuclear energy demands an urgent solution to the health problems arising from the discharge into the environment of radioactive residues produced by nuclear installations. - To be able to evaluate the risks run by the population and to fix tolerance limits for waste discharge, it is necessary to possess an exact knowledge of the course taken by the radioelements discharged, from their source until they reach man. The incorporation of radioelements in food cycles is the first risk to take into consideration. The factors involved in all stages of this transmission must be foreseen, whether they concern physical or biological media, because of their continuity and their interdependence. Finally, socio-economic and dietetic data must be collected in order that the risks and tolerance levels estimated are based on concrete and experimental rather than theoretical knowledge. The risk of nuclear accidents in the atomic industry, although very improbable, must be taken into consideration because of the seriousness of their consequences. The health problems arise in the field of professional hygiene on the one hand and in that of public hygiene on the other. In the first field the risk is two-fold and involves irradiation and contamination. The public sphere is reduced essentially to the risk of contamination by radioactive substances accidentally released in the surrounding medium. The health studies to be conducted in this field therefore include research not only on irradiation or contamination therapeutics but also on the transfer of radioelements from the accident site to man, mainly through food cycles, in their physical and in their biological components. Studies of this kind form the basis of decisions in the health field which would have to be taken in the case of an accident. (authors) [French] Le developpement rapide de l'energie nucleaire rend urgente la solution des problemes sanitaires poses par le rejet dans le milieu ambiant des

  9. Grade scale for nuclear incidents or accidents and events in radioprotection within the frame of radio-therapies; Les echelles de classement des incidents et accidents nucleaires et des evenements en radioprotection dans le cadre de radiotherapies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This leaflet presents the French 'ASN-SFRO' classification scale which assigns grades to radioprotection events occurring within the frame of a radiotherapy procedure. Depending on the severity, this scale defines different accident, incident or event levels. Classification criteria are commented. They are related to recognized consequences, to dose and potential effects, or to the number of exposed patients

  10. Bill project authorizing the approval of the agreement between the French Republic Government and the Government of the Republic of India related to the allocation of intellectual property rights in the agreements on the development of peaceful uses of nuclear energy - No. 4021; Projet de loi autorisant l'approbation de l'accord entre le Gouvernement de la Republique francaise et le Gouvernement de la Republique de l'Inde relatif a la repartition des droits de propriete intellectuelle dans les accords de developpement des utilisations pacifiques de l'energie nucleaire - No. 4021

    Energy Technology Data Exchange (ETDEWEB)

    Juppe, Alain [Ministere des Affaires Etrangeres et Europeennes, 37 Quai d' Orsay, 75007 Paris (France); Fillon, Francois [Premier ministre, Hotel de Matignon, 57, rue de Varenne, 75700 Paris (France)

    2011-12-01

    This document is related to the nuclear cooperation agreement signed in September 2008 between France and India. As this cooperation may have different aspects and lead to different kinds of exchanges between both countries, the allocation of intellectual property rights is an important issue, and has also to deal with the Indian legal context. Thus, this agreement defines the main notions (intellectual property, application agreement, common results, own knowledge), outlines the importance of intellectual property protection, defines the modalities of use of information, outlines the need to foresee a protection for confidential information, addresses the use of information which is already existing or which is produced within the cooperation, and defines the main guidelines for the protection, the allocation and the use of common results obtained within the cooperation

  11. Isolated Hb Providence β82Asn and β82Asp fractions are more stable than native HbA(0) under oxidative stress conditions.

    Science.gov (United States)

    Abraham, Bindu; Hicks, Wayne; Jia, Yiping; Baek, Jin Hyen; Miller, Jeffery L; Alayash, Abdu I

    2011-11-15

    We have previously shown that hydrogen peroxide (H(2)O(2)) triggers irreversible oxidation of amino acids exclusive to the β-chains of purified human hemoglobin (HbAo). However, it is not clear, whether α- or β-subunit Hb variants exhibit different oxidative resistance to H(2)O(2) when compared to their native HbAo. Hb Providence contains two β-subunit variants with single amino acid mutations at βLys82→Asp (βK82D) and at βLys82→Asn (βK82N) positions and binds oxygen at lower affinity than wild type HbA. We have separated Hb Providence into its 3 component fractions, and contrasted oxidative reactions of its β-mutant fractions with HbAo. Relative to HbAo, both βK82N and βK82D fractions showed similar autoxidation kinetics and similar initial oxidation reaction rates with H(2)O(2). However, a more profound pattern of changes was seen in HbAo than in the two Providence fractions. The structural changes in HbAo include a collapse of β-subunits, and α-α dimer formation in the presence of excess H(2)O(2). Mass spectrometric and amino acid analysis revealed that βCys93 and βCys112 were oxidized in the HbAo fraction, consistent with oxidative pathways driven by a ferrylHb and its protein radical. These amino acids were oxidized at a lesser extent in βK82D fraction. While the 3 isolated components of Hb Providence exhibited similar ligand binding and oxidation reaction kinetics, the variant fractions were more effective in consuming H(2)O(2) and safely internalizing radicals through the ferric/ferryl pseudoperoxidase cycle.

  12. Electronic structure and thermoelectric properties of pnictogen-substituted ASn{sub 1.5}Te{sub 1.5} (A = Co, Rh, Ir) skutterudites

    Energy Technology Data Exchange (ETDEWEB)

    Zevalkink, Alex [Thermal Energy Conversion Technologies Group, Jet Propulsion Laboratory, 4800 Oak Grove Drive, Pasadena, California 91109 (United States); Department of Materials Science, California Institute of Technology, 1200 E California Blvd, Pasadena, California 91125 (United States); Star, Kurt; Fleurial, Jean-Pierre; Bux, Sabah [Thermal Energy Conversion Technologies Group, Jet Propulsion Laboratory, 4800 Oak Grove Drive, Pasadena, California 91109 (United States); Aydemir, Umut; Snyder, G. Jeffrey [Department of Materials Science, California Institute of Technology, 1200 E California Blvd, Pasadena, California 91125 (United States); Vo, Trinh; Allmen, Paul von [Instrument Software and Science data systems Group, Jet Propulsion Laboratory, 4800 Oak Grove Drive, Pasadena, California 91109 (United States)

    2015-07-21

    Substituting group 14 and 16 elements on the pnictogen site in the skutterudite structure yields a class of valence-precise ternary AX{sub 1.5}Y{sub 1.5} compounds (A = Co, Rh, Ir, X = Sn, Ge, and Y = S, Se, Te), in which X and Y form an ordered sub-structure. Compared with unfilled binary skutterudites, pnictogen-substituted phases exhibit extremely low lattice thermal conductivity due to increased structural complexity. Here, we investigate the role of the transition metal species in determining the electronic structure and transport properties of ASn{sub 1.5}Te{sub 1.5} compounds with A = Co, Rh, Ir. Density functional calculations using fully ordered structures reveal semiconducting behavior in all three compounds, with the band gap varying from 0.2 to 0.45 eV. In CoSn{sub 1.5}Te{sub 1.5}, the electronic density of states near the gap is significantly higher than for A = Ir or Rh, leading to higher effective masses and higher Seebeck coefficients. Experimentally, Ir and Rh samples exhibit relatively large p-type carrier concentrations and degenerate semiconducting behavior. In contrast, CoSn{sub 1.5}Te{sub 1.5} shows mixed conduction, with n-type carriers dominating the Seebeck coefficient and light, high mobility holes dominating the Hall coefficient. zT values of up to 0.35 were obtained, and further improvement is expected upon optimization of the carrier concentration or with n-type doping.

  13. D1-Asn-298 in photosystem II is involved in a hydrogen-bond network near the redox-active tyrosine YZfor proton exit during water oxidation.

    Science.gov (United States)

    Nagao, Ryo; Ueoka-Nakanishi, Hanayo; Noguchi, Takumi

    2017-12-08

    In photosynthetic water oxidation, two water molecules are converted into one oxygen molecule and four protons at the Mn 4 CaO 5 cluster in photosystem II (PSII) via the S-state cycle. Efficient proton exit from the catalytic site to the lumen is essential for this process. However, the exit pathways of individual protons through the PSII proteins remain to be identified. In this study, we examined the involvement of a hydrogen-bond network near the redox-active tyrosine Y Z in proton transfer during the S-state cycle. We focused on spectroscopic analyses of a site-directed variant of D1-Asn-298, a residue involved in a hydrogen-bond network near Y Z We found that the D1-N298A mutant of Synechocystis sp. PCC 6803 exhibits an O 2 evolution activity of ∼10% of the wild-type. D1-N298A and the wild-type D1 had very similar features of thermoluminescence glow curves and of an FTIR difference spectrum upon Y Z oxidation, suggesting that the hydrogen-bonded structure of Y Z and electron transfer from the Mn 4 CaO 5 cluster to Y Z were little affected by substitution. In the D1-N298A mutant, however, the flash-number dependence of delayed luminescence showed a monotonic increase without oscillation, and FTIR difference spectra of the S-state cycle indicated partial and significant inhibition of the S 2 → S 3 and S 3 → S 0 transitions, respectively. These results suggest that the D1-N298A substitution inhibits the proton transfer processes in the S 2 → S 3 and S 3 → S 0 transitions. This in turn indicates that the hydrogen-bond network near Y Z can be functional as a proton transfer pathway during photosynthetic water oxidation. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  14. Association between TPO Asn698Thr and Thr725Pro gene polymorphisms and serum anti-TPO levels in Iranian patients with subclinical hypothyroidism.

    Science.gov (United States)

    Khoshi, Amirhosein; Sirghani, Alireza; Ghazisaeedi, Mehran; Mahmudabadi, Ali Zare; Azimian, Amir

    2017-01-01

    Subclinical hypothyroidism (SCH) is defined as high levels of TSH in the presence of normal levels of serum FT4. Since thyroid peroxidase (TPO) plays a key role in thyroid hormone synthesis, variations in the TPO gene can change the enzyme structure and result in the production of anti-TPO antibodies. The aim of this study was to examine the relationship between the Asn698Thr (A2095C) and Thr725Pro (A2173C) polymorphisms of the TPO gene and anti-TPO levels in patients with SCH. In this study, 150 individuals (75 cases and 75 controls), aged 19-75 years, were selected randomly by a clinician. The thyroid function tests included were FT3, FT4, TSH and anti-TPO antibodies using ELISA. The TPO gene polymorphisms were examined by PCR-RFLP. Anti-TPO levels in the experimental group was significantly increased (P=0.020). The A2095C genotype frequency in the experimental and control groups were 37.3% vs 34.7% for the AA healthy genotype, 20% vs 46.7% for AC and 42.7% vs 18.6% for CC, respectively (P=0.001). The A2173C genotype frequency in the experimental and control groups were 22.6% vs 68% for healthy AA, 40% vs 25.3% for AC and 37.4% vs 6.7% for CC, respectively (P TPO antibodies were significantly associated with the A2173C polymorphism (P=0.035). The findings showed that the chance (odds ratio) of developing subclinical hypothyroidism in individuals who had C alleles was 1.5 and 5.6-fold higher than in individuals without these alleles in the A2095C and A2173C regions, respectively. Determination of anti-TPO antibody levels and exon 12 TPO gene polymorphisms in patients with SCH can be helpful for prediction of overt hypothyroidism.

  15. Improvement of pressure-vessel surveillance of a PWR-power plant of the Societe d'Energie Nucleaire Franco-Belge des Ardennes (S.E.N.A.)

    International Nuclear Information System (INIS)

    Bevilacqua, A.; Lloret, R.; Riehl, R.

    1984-01-01

    This paper describes a new dosimetry, installed inside and outside the Pressure Vessel of CHOOZ Nuclear Power Plant of the Societe d'Energie Nucleaire Franco-Belge des Ardennes (S.E.N.A.), during its 1982-83 operation cycle. The inner dosimetry deals with a simulated capsule located under the reactor plate, and includes copper, nickel, iron, niobium, copper-cobalt, neptunium and uranium dosimeters. Its aim is to qualify the information given by the existing copper dosimetry. The spectrum used with these measurements is obtained by the 1 D ANISN Code and BIP-N 2 library. The outer dosimety is the fluence determination along the outer wall of the vessel. Two tubes, equiped by neutron dosimeters, seven meters long, were fixed along the vessel. On the median plane, the results are compared to a 2 D DOT transport calculation. Preliminary results are given which improve the vessel and specimens neutronic characterisation. (Auth.)

  16. Can-rupture detection in gas-cooled nuclear reactors; La detection des ruptures de gaine dans les piles nucleaires refroidies par gaz

    Energy Technology Data Exchange (ETDEWEB)

    Roguin, A. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1965-07-01

    Can-rupture detection (DRG) is one important aspect of pile safety, more particularly so in the case of gas-cooled reactors. A rapid and sure detection constitutes also an improvement as far as the efficiency of electricity-producing nuclear power stations are concerned. Among the numerous can-rupture detection methods, that based on the measurement of the concentration of short-lived fission gases in the heat-carrying fluid has proved to be the most sensitive and the most rapid. A systematic study of detectors based on the electrostatic collection of the daughter products of fission gases has been undertaken with a view to equip the reactors EL 2, G 3, EDF 1, EDF 2 and EDF 3, the gas loops of PEGASE and EL 4. The different parameters are studied in detail in order to obtain a maximum sensitivity and to make it possible to construct detection devices having the maximum operational reliability and requiring the minimum maintenance. The primary applications of these devices are examined in the case of the above-mentioned reactors. (author) [French] La Detection des Ruptures de Gaines (D. R. G.) est un aspect important de la securite des piles et plus particulierement des piles refroidies par un gaz. Une detection rapide et sure constitue aussi un element d'amelioration du rendement des centrales nucleaires productrices d'energie electrique. Parmi les nombreuses methodes de detection des ruptures de gaines, la mesure de la concentration dans le fluide caloporteur des gaz de fission a vie courte s'est revelee comme la plus sensible et la plus rapide. Une etude systematique des detecteurs a collection electrostatique des descendants des gaz de fission a ete entreprise en vue d'equiper les piles EL 2, G 3, EDF 1, EDF 2 et EDF 3, les boucles a gaz de la pile Pegase et la pile EL 4. Les divers parametres sont etudies en detail pour obtenir une sensibilite maximum et permettre la realisation de dispositifs de detection ayant le maximum de securite de

  17. Summary of the report A.S.N. n. 2006 ENSTR 019 - IGAS n. RM 2007-015P on the Epinal radiotherapy accident; Resume du rapport ASN n. 2006 ENSTR 019 - IGAS n. RM 2007-015P sur l'accident de radiotherapie d'Epinal

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The Nuclear Safety Authority (A.S.N.) and the General Inspection of Social Affairs (I.G.A.S.) have been in charge by the Ministry of an inquiry on the accident that has lead to the overdose of 23 patients irradiated for a prostate cancer at the Hospital of Epinal. This event constitutes the most important accident implying the ionizing radiations occurring in France. In may 2004, the protocol of conformal radiotherapy applied to the prostate cancers has been modified, it uses dynamics corners in place of static corners. This change supposes to modify the parameters definition that gives the calculation of irradiation intensity, that will not not be made for some of patients. This mistake could be changed if the in vivo dosimetry that allows to check the real dose received by the patients had been kept. but this line of safety has been removed, the use of dynamic corners making it ineffective. The period of over irradiation has been from the 6. may 2004 to the 1. august 2005. During the summer 2005, the radiotherapist and radio physicist find the overdose error by examining the patients files again. On the 15. september 2005, the two doctors of the service warn the director of the C.H.J.M. (hospital center of Jean Monnet) of the accident that informs D.D.A.S.S. (departmental direction of sanitary and social affairs) and A.R.H. (regional agencies of hospitalization). But the national authorities (A.F.S.S.A.P.S., A.S.N., I.R.S.N.) have not been warned, and so nobody can recognize the unsuitable character of the decided measures. Only seven patients are informed of the overdose of radiations they received during the last trimester 2005. The assistance to the victims is not organised the first year. All the patients have received usual treatments when they should receive a treatment by graft of mesenchymatous stem cells. Between september 2005 and september 2006 four patients died and ten present serious complications. propositions have been made to help the victims and

  18. Report realized on behalf of the Foreign Affairs Commission, of Defense and Armed Forces on the law project allowing the agreement approbation between the French Republic Government and the Russian Federal Government relative to the civil liability concerning the nuclear damages occurring from goods supplying to nuclear facilities in Russian Federation and becoming from the French Republic; Rapport fait au nom de la commission des affaires etrangeres, de la defense et des forces armees sur le projet de loi autorisant l'approbation de l'accord entre le Gouvernement de la Republique francaise et le Gouvernement de la Federation de Russie relatif a la responsabilite civile au titre de dommages nucleaires du fait de fournitures en provenance de la Republique francaise destinees a des installations nucleaires en Federation de Russie

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    The first part presents the international civil liability system in the nuclear domain and details then the 20 june 2000 agreement. It presents also the main aspects of the french-russian cooperation in the nuclear domain. (A.L.B.)

  19. Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS

    Directory of Open Access Journals (Sweden)

    Wang Bin

    2007-12-01

    Full Text Available Abstract Background CCR5-restricted (R5 human immunodeficiency virus type 1 (HIV-1 variants cause CD4+ T-cell loss in the majority of individuals who progress to AIDS, but mechanisms underlying the pathogenicity of R5 strains are poorly understood. To better understand envelope glycoprotein (Env determinants contributing to pathogenicity of R5 viruses, we characterized 37 full-length R5 Envs from cross-sectional and longitudinal R5 viruses isolated from blood of patients with asymptomatic infection or AIDS, referred to as pre-AIDS (PA and AIDS (A R5 Envs, respectively. Results Compared to PA-R5 Envs, A-R5 Envs had enhanced fusogenicity in quantitative cell-cell fusion assays, and reduced sensitivity to inhibition by the fusion inhibitor T-20. Sequence analysis identified the presence of Asn 362 (N362, a potential N-linked glycosylation site immediately N-terminal to CD4-binding site (CD4bs residues in the C3 region of gp120, more frequently in A-R5 Envs than PA-R5 Envs. N362 was associated with enhanced fusogenicity, faster entry kinetics, and increased sensitivity of Env-pseudotyped reporter viruses to neutralization by the CD4bs-directed Env mAb IgG1b12. Mutagenesis studies showed N362 contributes to enhanced fusogenicity of most A-R5 Envs. Molecular models indicate N362 is located adjacent to the CD4 binding loop of gp120, and suggest N362 may enhance fusogenicity by promoting greater exposure of the CD4bs and/or stabilizing the CD4-bound Env structure. Conclusion Enhanced fusogenicity is a phenotype of the A-R5 Envs studied, which was associated with the presence of N362, enhanced HIV-1 entry kinetics and increased CD4bs exposure in gp120. N362 contributes to fusogenicity of R5 Envs in a strain dependent manner. Our studies suggest enhanced fusogenicity of A-R5 Envs may contribute to CD4+ T-cell loss in subjects who progress to AIDS whilst harbouring R5 HIV-1 variants. N362 may contribute to this effect in some individuals.

  20. Guatemala: Ozbrojený konflikt 1960-1996 a současná situace: se zvláštním zaměřením na Máje

    OpenAIRE

    Vilímková, Olga

    2009-01-01

    Tématem disertační práce je Guatemala: ozbrojený konflikt v letech 1960 - 1996 a současná situace se zvláštním zaměřením na Máje. Příčiny ozbrojeného konfliktu druhé ploviny XX. století (a mnoha současných problémů) v Guatemale se nacházejí v hluboké minulosti země. Už v době koloniální se začaly formovat ekonomicko - sociální vztahy mezi dvěma antagonistickými vrstvami společnosti: kolonizátory a původním obyvatelstvem, které bylo porobeno, vytlačeno na okraj společnosti a využíváno jako pra...

  1. Contribution to the study of the evolution of radiation induced He in Be O; Etudes sur l'evolution de l'helium produit par reactions nucleaires dans l'oxyde de beryllium

    Energy Technology Data Exchange (ETDEWEB)

    Bareau, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1966-11-15

    The purpose of this work in-pile investigation of He formed by (n, 2n) and (n, {alpha}) nuclear reactions, released from irradiated BeO, in the temperature range 1000 - 1350 deg. C. The experimental results show that, for an instantaneous neutron fast flux of 10{sup 13} n cm{sup -2} sec{sup -1}, an equilibrium is attempted, after several days, for a part lower than 20 per cent of the quantity of He formed, theoretically calculated from the neutron cross sections of nuclear reactions, and from the analytical form of the neutron fast flux, releases from the solid. The validity of the values of calculated helium and the gas chromatographic analytical method are also verified by dissolution of the BeO pellets in cryolite. A new fast neutron flux measuring method may be so defined. The discussion of the experimental results enables to establish that the processus of He release is characterized by two phenomena: the first one which controls the release of He atoms out of the solid and the second which reveals a capture processus, connected to the irradiation and probably due to the vacancies induced in the lattice. (author) [French] On etudie en pile le degagement de l'helium forme par reactions nucleaires (n, 2 n) et (n, {alpha}) dans l'oxyde de beryllium irradie entre 1000 et 1350 deg. C. Les resultats experimentaux montrant que, pour un flux rapide instantane de 10{sup 13} n{sub r} cm{sup -2} s{sup -1}, on aboutit, au bout de quelques jours, a un etat d'equilibre pour lequel une partie, inferieure a 20 pour cent de la quantite d'helium forme, calculee theoriquement a partir des sections efficaces des reactions nucleaires et de la forme analytique du flux rapide, s'echappe du solide. On verifie egalement par dissolution des echantillons de BeO dans la cryolithe la validite du calcul de l'helium et de la methode de dosage par chromatographie en phase gazeuse. On peut ainsi definir une methode nouvelle de mesure des flux rapides. La

  2. In vitro antioxidant activities of the novel pentapeptides Ser-His-Glu-Cys-Asn and Leu-Pro-Phe-Ala-Met and the relationship between activity and peptide secondary structure

    DEFF Research Database (Denmark)

    Yang, Ruiwen; Wang, Jia; Lin, Songyi

    2017-01-01

    ) inhibition, and oxygen radical absorbance capacity (ORAC) assays. Finally, the secondary structure was determined using circular dichroism (CD). RESULTS: The results revealed that two novel peptides were nontoxic and possessed antioxidant activity. SHECN had significantly higher antioxidant activity than......BACKGROUND: Using high-performance liquid chromatography/tandem mass spectrometry, two novel antioxidant pentapeptides [Ser-His-Glu-Cys-Asn (SHECN) and Leu-Pro-Phe-Ala-Met (LPFAM)] were identified from 1-3-kDa soybean protein hydrolysates (SPH). The MTT [3-(4,5-dimethylthiazol-2-yl)-2......,5-diphenyltetrazolium bromide] assay was used to evaluate cytotoxicity in HepG2 cells. Antioxidant activity was measured using in vitro assays, including the cellular antioxidant activity assay (CAA), 2,2-diphenyl-1-picrylhydrazyl or 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS...

  3. Conformity of nuclear construction codes with the requirements of the French order dated December 12, 2005 related to nuclear pressure equipment; Conformite des codes de construction nucleaires avec les exigences de l'arrete du 12 decembre 2005 relatif aux equipements sous pression nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Grandemange, J.M.; Renaut, P. [Areva-NP, Tour AREVA, 92084 - Paris La Defense cedex, (France); Paris, D. [EDF-Ceidre 2 rue Ampere - 93206 SAINT-DENIS Cedex (France); Faidy, C. [EDF-Septen 12/14, Avenue Dutrievoz 69628 Villeurbanne Cedex (France)

    2007-07-01

    The French Decree dated December 13, 1999 transposing the Pressure Equipment Directive (PED) has replaced the fundamental texts on which up to now the regulation for pressure equipment important for the safety of nuclear reactors was also founded. By a Ministerial Order - called 'ESPN Order' - dated December 12, 2005, a new regulation has been issued for nuclear pressure equipment. This text makes reference to the Decree transposing the PED while completing these provisions by supplementary requirements having the objective to provide a very high level of integrity guarantee for equipments which are the most important for safety, and to cover the prevention of radioactive release risks. These regulatory evolutions are presented in the Plenary Session of the ESOPE conference. Referencing the Decree and thus the PED, and including specific provisions, the Ministerial Order implies that the Manufacturers update their documents and, if necessary, their prescriptions in the following two domains: - that of the conformity of Codes and Standards used, generally inspired from the ASME Code Section III, with the essential safety requirements of the PED, - that of the respect of the complementary provisions brought by the ESPN Order. This paper presents the more significant conclusions of this work and the resulting amendments of the RCC-M Code, introduced by the 2007 addendum to that Code. The analysis will lead to specify the same type of complementary requirements to Code when a manufacturer wishes to use the German KTA Rules or the ASME Code Section III. (authors) [French] Le decret du 13 decembre 1999 transposant la directive europeenne (DESP) relative aux equipements sous pression a remplace les textes fondamentaux sur lesquels se fondait egalement jusque la la reglementation des appareils a pression importants pour la surete des reacteurs nucleaires. Par arrete - dit 'arrete ESPN' - du 12 decembre 2005, une nouvelle reglementation a ete dictee. Ce

  4. Nuclear medicine; La medecine nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Sibille, L. [Hopital Lapeyronie CHU Montpellier, Medecine Nucleaire, 34 - Montpellier (France); Nalda, E.; Collombier, L.; Kotzki, P.O.; Boudousq, V. [CHU de Nimes, Service de Medecine Nucleaire et de biophysique, 30 - Nimes (France)

    2011-05-15

    Nuclear medicine is a medical specialty using the properties of radioactivity. Radioactive markers associated with vectors are used as a tracer or radiopharmaceutical for diagnostic purposes and/or therapy. Since its birth more than half a century ago, it has become essential in the care of many patients, particularly in oncology. After some definitions, this paper presents the main nuclear techniques - imaging for diagnostic, radiopharmaceuticals as therapeutic agents, intra-operative detection, technique of radioimmunoassay - and the future of this field. (authors)

  5. Information sur les technologies nucleaires

    CERN Multimedia

    2002-01-01

    "La base Inis (International Nuclear Information System) de l'Agence Internationale d'Energie Atomique (IAEA) dispose desormais de liens vers les textes complets de documents internationaux" (1 paragraph).

  6. Nuclear fuels; Les combustibles nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    The nuclear fuel is one of the key component of a nuclear reactor. Inside it, the fission reactions of heavy atoms, uranium and plutonium, take place. It is located in the core of the reactor, but also in the core of the whole nuclear system. Its design and properties influence the behaviour, the efficiency and the safety of the reactor. Even if it represents a weak share of the generated electricity cost, its proper use represents an important economic stake. Important improvements remain to be made to increase its residence time inside the reactor, to supply more energy, and to improve its robustness. Beyond the economical and safety considerations, strategical questions have to find an answer, like the use of plutonium, the management of resources and the management of nuclear wastes and real technological challenges have to be taken up. This monograph summarizes the existing knowledge about the nuclear fuel, its behaviour inside the reactor, its limits of use, and its R and D tracks. It illustrates also the researches in progress and presents some key results obtained recently. Content: 1 - Introduction; 2 - The fuel of water-cooled reactors: aspect, fabrication, behaviour of UO{sub 2} and MOX fuels inside the reactor, behaviour in loss of tightness situation, microscopic morphology of fuel ceramics and evolution under irradiation - migration and localisation of fission products in UOX and MOX matrices, modeling of fuels behaviour - modeling of defects and fission products in the UO{sub 2} ceramics by ab initio calculations, cladding and assembly materials, pellet-cladding interaction, advanced UO{sub 2} and MOX ceramics, mechanical behaviour of the fuel assembly, fuel during a loss of coolant accident, fuel during a reactivity accident, fuel during a serious accident, fuel management inside reactor cores, fuel cycle materials balance, long-term behaviour of the spent fuel, fuel of boiling water reactors; 3 - the fuel of liquid metal fast reactors: fast neutrons radiation-induced damages in structural materials, fuels and targets for the transmutation in FBR; 4 - the fuel of gas-cooled reactors: fuel particulates, behaviour under irradiation, mechanical modeling, the fuel for very high temperature reactors, the fuel for gas-cooled fast reactors; 5 - the fuel for research reactors; 6 - the Jules Horowitz reactor: a tool for the future fuel studies. (J.S.)

  7. Development of a power-period calculation unit for nuclear reactor Control; Etude et realisation d'un ensemble de calcul puissance periode pour le controle d'un reacteur nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Martin, J. [Commissariat a l' Energie Atomique, Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France)

    1966-10-01

    The apparatus studied is a digital calculating assembly which makes it possible to prepare and to present numerically the period and power of a nuclear reactor during operation, from start-up to nominal power. The pulses from a fission chamber are analyzed continuously, using real time. A small number of elements is required because of the systematic use of a calculation technique comprising the determination of a base 2 logarithm by a linear approximation. The accuracy obtained for the period is of the order of 14%; the response time of the order of the calculated period value. An approximate value of the power (30%) is given at each calculation cycle together with the power thresholds required for the control. (author) [French] L'appareil etudie est un ensemble de calcul digital permettant d'elaborer et d'afficher numeriquement la periode et la puissance, d'un reacteur nucleaire lors de son fonctionnement depuis le demarrage jusqu'a la puissance nominale. Il traite en temps reel, de facon continue, les impulsions en provenance d'une chambre de fission. Grace a l'utilisation systematique d'une technique de calcul, la determination d'un logarithme a base 2 par approximation lineaire, un nombre reduit d'elements est utilise. La precision obtenue sur la periode est de l'ordre de 14 pour cent, le temps de reponse de l'ordre de la valeur de la periode calculee. Un ordre de grandeur de la puissance (30 pour cent) est donne a chaque cycle de calcul ainsi que des seuils de puissance necessaires au controle. (auteur)

  8. Chemical elimination of alumina in suspension in nuclear reactors heavy water; Elimination de l'alumine en suspension dans l'eau lourde des reacteurs nucleaires par voie chimique

    Energy Technology Data Exchange (ETDEWEB)

    Ledoux, A. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-02-01

    Corrosion of aluminium in contact with moderating water in nuclear reactor leads to the formation of an alumina hydrosol which can have an adverse effect on the operation of the reactor. Several physical methods have been used in an attempt to counteract this effect. The method proposed here consists in the elimination of the aluminium by dissolution and subsequent fixation in the ionic form on mixed-bed ion-exchange resin. In order to do this, the parameters and the values of these parameters most favorable to the dissolution process have been determined. If the moderator is heavy water, the deuterated acid can be prepared by converting a solution in heavy water to a salt of the acid using a deuterated cationic resin. (author) [French] La corrosion de l'aluminium au contact de l'eau moderatrice des reacteurs nucleaires, donne lieu a la formation d'un hydrosol d'alumine nuisible au bon fonctionnement des reacteurs. Plusieurs methodes physiques ont ete mises en oeuvre pour pallier ces inconvenients. On propose ici d'eliminer l'alumine par solubilisation pour la fixer ensuite sous forme ionique par des resines echangeuses d'ions, en lit melange. A cette fin on determine les parametres et leurs grandeurs favorables a cette solubilisation. Si le moderateur est de l'eau lourde la preparation d'acide deutere peut etre effectuee par passage d'une solution en eau lourde a un sel de l'acide sur resine cationique deuteree.

  9. Contribution to the study of solid helium-3 by nuclear magnetic resonance; Contribution a l'etude de l'helium trois solide par resonance magnetique nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Landesman, A. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-07-01

    Due to the unusually large zero point motion of helium three atoms in the solid, the overlap of the atomic wave functions is very important. As a consequence, there are exchange interactions, the theoretical calculation and the experimental measurement of which are discussed. Nuclear magnetic resonance is especially well suited for the latter.A detailed theory is given for both exchange narrowing and Zeeman-exchange cross relaxation, which phenomena are used to measure the exchange interaction as a function of molar volume. The alignment temperature is thus known; it goes down when the pressure goes up and is never higher than three milli degrees. An influence of helium four impurities on the exchange interactions between helium three atoms which are neighbours of the substitutional He is shown. (author) [French] Par suite de l'amplitude exceptionnelle des mouvements de point zero dans l'helium trois solide, le recouvrement des fonctions d'onde atomiques est tres important. Il en resulte des interactions d' echange dont on discute l'evaluation theorique et la mise en evidence experimentale. Cette derniere peut se faire par resonance magnetique; on etudie theoriquement les phenomenes de retrecissement par echange et de relaxation Zeeman-echange que l'on met a profit pour determiner les interactions d'echange en fonction du volume molaire. On en deduit que la temperature d'alignement nucleaire diminue quand on comprime le solide et est au plus de 3x10{sup -3} K. L'influence des impuretes d'helium quatre sur les interactions d'echange entre atomes {sup 3}He voisins de {sup 4}He est mise en evidence. (auteur)

  10. Phenotypic characteristics of the p.Asn215Ser (p.N215S) GLA mutation in male and female patients with Fabry disease: A multicenter Fabry Registry study.

    Science.gov (United States)

    Germain, Dominique P; Brand, Eva; Burlina, Alessandro; Cecchi, Franco; Garman, Scott C; Kempf, Judy; Laney, Dawn A; Linhart, Aleš; Maródi, László; Nicholls, Kathy; Ortiz, Alberto; Pieruzzi, Federico; Shankar, Suma P; Waldek, Stephen; Wanner, Christoph; Jovanovic, Ana

    2018-04-12

    The p.Asn215Ser or p.N215S GLA variant has been associated with late-onset cardiac variant of Fabry disease. To expand on the scarce phenotype data, we analyzed natural history data from 125 p.N215S patients (66 females, 59 males) enrolled in the Fabry Registry (NCT00196742) and compared it with data from 401 patients (237 females, 164 males) harboring mutations associated with classic Fabry disease. We evaluated interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPWT), estimated glomerular filtration rate and severe clinical events. In p.N215S males, mildly abnormal mean IVST and LVPWT values were observed in patients aged 25-34 years, and values gradually increased with advancing age. Mean values were similar to those of classic males. In p.N215S females, these abnormalities occurred primarily in patients aged 55-64 years. Severe clinical events in p.N215S patients were mainly cardiac (males 31%, females 8%) while renal and cerebrovascular events were rare. Renal impairment occurred in 17% of p.N215S males (mostly in patients aged 65-74 years), and rarely in females (3%). p.N215S is a disease-causing mutation with severe clinical manifestations found primarily in the heart. Cardiac involvement may become as severe as in classic Fabry patients, especially in males. © 2018 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.

  11. The G-protein regulatory (GPR) motif-containing Leu-Gly-Asn-enriched protein (LGN) and Gialpha3 influence cortical positioning of the mitotic spindle poles at metaphase in symmetrically dividing mammalian cells.

    Science.gov (United States)

    Blumer, Joe B; Kuriyama, Ryoko; Gettys, Thomas W; Lanier, Stephen M

    2006-12-01

    We addressed the role of the G-protein regulatory (GPR) motif-containing Leu-Gly-Asn-enriched protein (LGN) and G-proteins (Gialpha3) in the positioning of the spindle pole during mammalian cell division. Immunocytochemistry indicated that both LGN and Gialpha3 co-localized at the spindle pole and at the midbody and the cell cortex during the different phases of mitosis. In marked contrast to the positioning of the spindle pole at metaphase midway between the cell cortex and the metaphase plate, the spindle pole was juxtaposed with the cell cortex at metaphase following increased expression of Gialpha3 and LGN. This repositioning of the spindle pole required the interaction of LGN with Gialpha. The influence of LGN and Gialpha3 on the cortical positioning of the spindle pole likely reflects either stronger pulling forces on the spindle pole exerted from the cell cortex or increased pushing forces exerted on the spindle pole from the mitotic spindle indicating that these events are regulated by GPR motif-containing proteins and G-proteins independent of asymmetry.

  12. Effect of elastic strain on the band gaps, band alignment, and electronic structure of epitaxial ASnO3 (A = Ca, Sr, and Ba) films and heterostructures revealed through in situ photoemission, spectroscopic ellipsometry, and density functional theory

    Science.gov (United States)

    Baniecki, John; Yamazaki, Takashi; Aso, Hiroyuki; Imanaka, Yoshihiko; Ricinschi, Dan

    The alkaline earth stannates ASnO3 (A = Ba, Sr, and Ca) are emerging as important materials. Band gaps in stannates are remarkably dependent on volumetric strain with a decrease in volumetric strain of 3 percent in SrSnO3 resulting in an increase in the band gap of 0.35 eV. However, little understanding of volumetric strain dependence on the valence band (VB) electronic structure and band alignments between stannates and other oxides exits. In this talk we will examine the effect of elastic strain on the band gaps, band alignment, and electronic structure of stannate films and heterostructures through in situ photoemission, spectroscopic ellipsometry, scanning transmission electron microscopy with geometric phase analysis, and density functional theory. CaSnO3 (CSO), SrSnO3 (SSO) and La-doped BaSnO3 (BLSO) thin films were grown by pulsed laser epitaxy with strain control via epitaxial buffer layers. While the VB electronic structure is strain dependent VB offsets do not vary significantly with strain, which resulted in ascribing most of the difference in band alignment to the conduction band (CB) edge. Significantly, strain-induced tuning of CB offset differences are as large as 0.6 eV for SSO and may provide a pathway to enhance stannate-based devices.

  13. A Mosaic Expression of a Hb J-Amiens (HBB: c.54G > T; p.Lys18Asn) and its Interference with Hb A1c Analysis.

    Science.gov (United States)

    Schiemsky, Toon; Van Hoovels, Lieve; Desmet, Koen J O; Phylipsen, Marion; Harteveld, Cornelis L; Kieffer, Davy M J

    2015-01-01

    We report the case of a 56-year-old Caucasian woman in whom hemoglobinopathy screening was triggered following an aberrant Hb A1c analysis. Preliminary diagnosis of the hemoglobin (Hb) variant was obtained through cation exchange high performance liquid chromatography (HPLC) and gel electrophoresis. DNA analysis confirmed the presence of Hb J-Amiens [β17(A14)Lys→Asn; HBB: c.[54G > C or 54G > T)]. However, an unbalanced ratio between wild type and mutant signal after direct sequencing and a lower than expected percentage of this Hb variant led to the suggestion of a mosaic expression. Furthermore, different methods [capillary zone electrophoresis (CZE), cation exchange HPLC and boronate affinity] were tested to study the possible interference of this variant with Hb A1c measurements. These investigations showed a clinically relevant difference between the methods tested. Hb A1c analysis may lead to the discovery of new Hb variants or mosaicism for previously described Hb variants. This may have genetic consequences for the offspring of carriers and brings about the question of partner testing.

  14. Information note about the protection of nuclear facilities against aircraft crashes; Note d'information sur la protection des installations nucleaires contre les chutes d'avions

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The protection of nuclear facilities against external risks (earthquakes, floods, fires etc..) is an aspect of safety taken into consideration by the French authority of nuclear safety (ASN). Concerning the aircraft crashes, the fundamental safety rules make three categories of aircraft: the small civil aircraft (weight < 5.7 t), the military aircraft, and the commercial aircraft (w > 5.7 t). Nuclear facilities are designed to resist against crashes of aircraft from the first category only, because the probability of the accidental crash of a big aircraft are extremely low. This document comprises an information note about the protection of nuclear facilities against aircraft crashes, a dossier about the safety of nuclear facilities with respect to external risks in general (natural disasters and aircraft crashes), and an article about the protection of nuclear power plants against aircraft crashes (design, safety measures, regulation, surveillance, experience feedback). (J.S.)

  15. Organic chemistry and radiochemistry: study of chemical interactions between iodine and paint of French nuclear reactor in a severe accident situation; Chimie organique et radiochimie. Etude des interactions chimiques iode-peinture dans un reacteur nucleaire (de type R.E.P.) en situation d'accident grave

    Energy Technology Data Exchange (ETDEWEB)

    Aujollet, Y. [Direction Generale de la Surete Nucleaire et de la Radioprotection, 75 - Paris (France)

    2005-01-01

    In Phebus (French in pile facility; PWR scale 1/5000) experiments, performed by the Institut de Radioprotection et de Surete Nucleaire, few quantities of organic iodides were registered after interaction between iodine and reactor containment paint. This study concerns all mechanisms of chemical reactions between iodine and the polymer of the paint in order to estimate the organic iodides released from the paint. At first, all the paint components had been identified. Several models of chemical sites of the polymer were synthesized and tested with iodine in different conditions of temperature and radiation. These experiments showed interactions between iodine and secondary or tertiary amines by charge transfer. In few cases, the complex of tertiary amines creates oxidation reactions. (author)

  16. Vývoj a současný stav sociální pedagogiky v iberoamerickém regionu: pohled za horizont střední Evropy

    Directory of Open Access Journals (Sweden)

    Jitka Lorenzová

    2018-01-01

    Full Text Available Teoretická studie si klade za cíl nastínit vývoj a současný stav rozvoje sociální pedagogiky v iberoamerickém regionu. Smyslem je nabídnout české odborné veřejnosti další pohledy na tento obor a rozšířit interpretační horizont diskusí vedených na téma sociální pedagogiky v České republice. Článek je členěn na tři části, Nejdříve ukazuje vývoj sociálně pedagogického myšlení ve Španělsku od tzv. „generace 1914“, která byla ovlivněna novokantovstvím a P. Natorem, po současné pojetí sociální pedagogiky jako teorie profesně zaměřené sociálně pedagogické práce. Ve druhé části představuje koncept lidového vzdělávání jako hlavní zdroj poznatků sociální pedagogiky v Latinské Americe. Obraz vývoje je doplněn o přehled klíčových aktivit iberoamerické akademické komunity realizovaných v posledních dekádách na podporu rozvoje sociální pedagogiky. K závěrům studie patří poznatek, že sociální pedagogika se v iberoamerickém regionu rozvíjí velmi dynamicky. Je chápána jako věda, která se zaměřuje na otázky sociální integrace jedinců, skupin a komunit s cílem podpořit jejich rozvoj tak, aby se začlenili do rozmanitých sociálních sítí demokratické pluralitní společnosti. Také je zdůrazňováno, že jde o vědu, která musí neustále reflektovat svoje teoreticko-metodologická východiska i dopady sociálně pedagogických intervencí z hlediska demokratických a emancipačních sociálních hodnot.

  17. α-Thalassemia Associated with Hb Instability: A Tale of Two Features. The Case of Hb Rogliano or α1 Cod 108(G15)Thr→Asn and Hb Policoro or α2 Cod 124(H7)Ser→Pro.

    Science.gov (United States)

    Musollino, Gennaro; Cardiero, Giovanna; Flagiello, Angela; La Porta, Gaetana; Lagona, Laura; Prezioso, Romeo; Qualtieri, Gabriele; Gaudiano, Carlo; Medulla, Emilia; Merlino, Antonello; Pucci, Piero; Lacerra, Giuseppina

    2015-01-01

    We identified two new variants in the third exon of the α-globin gene in families from southern Italy: the Hb Rogliano, α1 cod108 ACC>AAC or α1[α108(G15)Thr→Asn] and the Hb Policoro, α2 cod124 TCC>CCC or α2[α124(H7)Ser→Pro]. The carriers showed mild α-thalassemia phenotype and abnormal hemoglobin stability features. These mutations occurred in the G and H helices of the α-globin both involved in the specific recognition of AHSP and β1 chain. Molecular characterization of mRNA, globin chain analyses and molecular modelling studies were carried out to highlight the mechanisms causing the α-thalassemia phenotype. The results demonstrated that the α-thalassemia defect associated with the two Hb variants originated by different defects. Hb Rogliano showed an intrinsic instability of the tetramer due to anomalous intra- and inter-chain interactions suggesting that the variant chain is normally synthesized and complexed with AHSP but rapidly degraded because it is unable to form the α1β1 dimers. On the contrary in the case of Hb Policoro two different molecular mechanisms were shown: the reduction of the variant mRNA level by an unclear mechanism and the protein instability due to impairment of AHSP interaction. These data highlighted that multiple approaches, including mRNA quantification, are needed to properly identify the mechanisms leading to the α-thalassemia defect. Elucidation of the specific mechanism leads to the definition of a given phenotype providing important guidance for the diagnosis of unstable variants. PMID:25730315

  18. The old and the new in prekallikrein deficiency: historical context and a family from Argentina with PK deficiency due to a new mutation (Arg541Gln) in exon 14 associated with a common polymorphysm (Asn124Ser) in exon 5.

    Science.gov (United States)

    Girolami, Antonio; Vidal, Josè; Sabagh, Marcela; Salagh, Marcela; Gervan, Nora; Parody, Maria; Peroni, Edoardo; Sambado, Luisa; Guglielmone, Hugo

    2014-07-01

    Prekallikrein (PK) is one of the clotting factors involved in the contact phase of blood. PK has an important historical role as its deficiency state represents the second instance of a clotting defect without bleeding manifestations, the first one being factor XII deficiency. PK deficiency is a rare clotting disorder. Moreover, only 11 patients have been investigated so far by molecular biology techniques. In this article, we briefly review some of the history around PK and also present some recent data on a newly identified family from Argentina suffering from PK deficiency. Two patients are homozygous whereas other family members are heterozygous. PK activity and antigen are 1% of normal in the homozygotes and around 60 to 70% of normal in the heterozygotes. As expected, all patients are asymptomatic of bleeding or thrombosis presentations. However, the two homozygotes showed essential hypertension. The PK deficiency in this family is due to a new mutation (Arg541Gln) in exon 14. The defect segregates together with a known polymorphism, Asn124Ser, in exon 5. The significance of the presence of hypertension in the two homozygotes is discussed in view of the extra coagulation effects of PK on vasodilation, vessel permeability, and the control of blood pressure. Structure function analysis indicates that the substitution of Arg with Gln probably impedes the transmembrane diffusion of the molecule, which therefore cannot be secreted in the homozygotes. The presence of hypertension in patients with PK deficiency has been previously reported in some but not all patients. Future research activities will probably concentrate on the effect of PK and other contact phase factors on the vascular system. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  19. Study and installation of concrete shielding in the civil engineering of nuclear construction (1960); Etude et mise en place des betons de protection dans le genie civil des ouvrages nucleaires (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Dubois, F. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    etudes, deux applications pratiques sont decrites telles qu'elles ont ete realisees au Centre d'Etudes Nucleaires de Saclay. Des specifications sont donnees pour les betons de barytine et pour la fabrication des blocs de protection du synchrotron a protons 'Saturne'. (auteur)

  20. Reactivity measurements on a sub-critical nuclear reactor using statistical fluctuations of the neutron flux; Mesure de la reactivite d'un reacteur nucleaire en regime sous-critique a partir des fluctuations statistiques du flux neutronique

    Energy Technology Data Exchange (ETDEWEB)

    Feghahati, E. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-07-01

    It is intended in this report to show that it is possible to design an apparatus for measuring the reactivity of a sub-critical nuclear reactor, using a spectral analysis of the variations in the output signal of a counter. The method proposed consists in the measurement of the spectral density in two frequency bands, and in the determination of the 'uncorrelated' components so as to obtain the 'correlated' components, the ratio of these two correlated components giving the reactivity if {beta}/l is known. It is concluded that this method could be applied with the help of a simple apparatus having a measurement range of up to -5000 pcm. Since the efficiency of the detector cannot be increased above a certain value, the accuracy depends largely on the time of measurement: it is shown that it is possible to measure -3000 pcm with an accuracy of {+-} 5 per cent for a time of measurement of 600 seconds. (author) [French] On propose, dans ce travail, de montrer qu'il est possible de realiser un appareil de mesure de la reactivite d'un reacteur nucleaire en regime sous-critique, a partir de l'analyse spectrale des fluctuations du signal de sortie d'un compteur. La methode proposee consiste a mesurer la densite spectrale dans deux bandes de frequences, et a determiner les composantes 'non correlees' de facon a obtenir les composantes 'correlees', le rapport de ces deux composantes correlees permet d'obtenir la reactivite lorsque l'on connait {beta}/l.On en conclut que cette methode peut conduire a la realisation d'un appareil simple, dont la gamme de mesure s'etend jusqu'a - 5 000 pcm. Puisque l'efficacite du detecteur ne peut etre augmentee au-dela d'une certaine valeur, la precision depend, pour une grande part, du temps de mesure: on montre que l'on peut mesurer -3000 pcm avec une precision de {+-} 5 pour cent pour une duree de la mesure de 600 secondes. (auteur)

  1. Regulation imposed to nuclear facility operators for the elaboration of 'waste studies' and 'waste statuses'; Reglementation imposee aux exploitants d'installations nucleaires pour l'elaboration ''des etudes dechets'' et ''des bilans dechets''

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-09-04

    This decision from the French authority of nuclear safety (ASN) aims at validating the new versions of the guidebook for the elaboration of 'waste studies' for nuclear facilities and of the specifications for the elaboration of 'waste statuses' for nuclear facilities. This paper includes two documents. The first one is a guidebook devoted to nuclear facility operators which fixes the rules of production of waste studies according to the articles 20 to 26 of the inter-ministry by-law from December 31, 1999 (waste zoning conditions and ASN's control modalities). The second document concerns the specifications for the establishment of annual waste statuses according to article 27 of the inter-ministry by-law from December 31, 1999 (rational management of nuclear wastes). (J.S.)

  2. Obtaining of the UE’s Fabrication Autorisation and of Good Manufacturing Fabrication Practice

    Directory of Open Access Journals (Sweden)

    Rodica Morcov

    2009-12-01

    Full Text Available The harmonization of Romania’s legislation with the European Union’s one has as purpose the authentic equivalence archiving of the elaborated and applied measures on the Romania’s theritory with the ones legislated and applied in the other European Union state members.This is mandatory for the administrative procedure for the drow up of fabrication/import authorizations for the veterinary medicine products, in conformity with the European Commission published models and is assured in our country by the ANSVSA Presidents’ Order no. 57/2009, to the modification of the earlyer ANSVSA Presidents Order no. 187/2007 about the approval of the Veterinary Medicine Products Code, Sanitary Veterinary Norm, order which transponds the Commission Directive 2009/9/CE from 10th February 2009 and modiffying the Directive 2001/82/CE of the European Parliament and of the Council for the instituition of the Communitary code regarding the veterinary medicine products, published in the Official Journal of the European Union (JOUE no. L 44 from 14th February 2009, which implements in the national legislations the authorizations for fabrication/ import communitary format for the veterinary medicine products,published by the European Commission in the Reglementation of the Veterinary Medicine Products Norms, volume 4, published in the Official Monitor Part 1, no. 611/08.09.2009.

  3. Preparation and study of the properties of lead telluride and cadmium telluride diodes for use in nuclear spectrometry; Preparation et etude des proprietes de diodes au tellurure de plomb et au tellurure de cadmium en vue d'une utilisation en spectrometrie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Lancon, R. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1969-07-01

    This work studies the possibility of using high atomic number compound semiconductors, like lead telluride and cadmium telluride as to realize nuclear radiation detectors, specially in gamma ray spectrometry because of their high absorption coefficient. The problems related to the preparation of binary compounds are exposed. Experiments on PbTe show the influence of the conditions of preparation on the electrical properties of the semiconductor which are greatly dependent on the stoichiometry of the compound. PbTe surface-barrier diodes were realized and have been used to study the surface properties of this semiconductor. These diodes cannot detect nuclear radiations because of the too weak resistivity of our material. Different types of devices made of Cd Te have been studied. One of these diodes has been used as an alpha particle detector. We explain the relative poor performances of that detector by the presence of lattice defects in Cd Te where charge carriers may recombine themselves. By analysing the properties of gold diffused Cd Te diodes we identified this defect, the cadmium vacancy, the presence of which is due to the deviation from stoichiometry during the preparation of the material. (author) [French] Ce travail etudie la possibilite d'utiliser des semiconducteurs composes d'elements a numero atomique eleve, tels que le tellurure de plomb et le tellurure de cadmium pour la realisation de detecteurs de rayonnements nucleaires, grace notamment a la section efficace de capture elevee qu'ils presentent vis-a-vis des rayons gamma. On souligne les problemes relatifs a la preparation des composes binaires. Les experiences realisees sur PbTe mettent en evidence l'influence des conditions de preparation sur les proprietes electriques du semiconducteur qui dependent fortement de la stoechiometrie du compose. Nous avons realise des diodes au PbTe a barriere de surface qui ont permis de preciser les proprietes de surface de ce semiconducteur

  4. Contribution to the study of molecular movements in cyclohexane by electron spin resonance and electron-nuclear double resonance using a radical probe; Contribution a l'etude des mouvements moleculaires dans le cyclohexane par resonance paramagnetique electronique et double resonance electronique-nucleaire a l'aide d'une sonde radicalaire

    Energy Technology Data Exchange (ETDEWEB)

    Volino, F. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1969-07-01

    Solutions of stable free radicals of the nitroxide type have been studied as a function of temperature. In the plastic or globular state, the cyclohexane molecules have rapid rotational and diffusional movements. They transmit this movement to dissolved free radicals. Conversely, measurements by electron spin resonance of the absolute movement of the radicals, and by electron nuclear double resonance of their movement relative to the cyclohexane molecules give very precise methods for local analyses of the movement present in the cyclohexane matrix. The principle of these techniques makes up the 'radical probe method'. (author) [French] Des solutions de radicaux libres stables, du type nitroxyde dans le cyclohexane ont ete etudiees, en fonction de la temperature. Les molecules de cyclohexane, dans l'etat plastique ou globulaire, sont animees de mouvements rapides de rotation sur elles-memes et de diffusion. Elles transmettent leur mobilite aux radicaux libres dissous. Reciproquement, la mesure du mouvement absolu des radicaux, a l'aide de la resonance paramagnetique electronique, et celle du mouvement relatif des radicaux et des molecules de cyclohexane par double resonance electronique-nucleaire, constituent des methodes tres precises pour analyser localement les mouvements presents dans la matrice de cyclohexane. Ce principe et ces techniques constituent la 'methode de la sonde radicalaire'. (auteur)

  5. Synthesis and purification of some alkyl phenanthrenes and presentation of their infrared, ultraviolet, nuclear magnetic resonance and mass spectra; Synthese et purification de quelques alcoylphenanthrenes et presentation ds leurs spectres d'absorption infrarouge, ultraviolette, de resonance magnetique nucleaire et de masse

    Energy Technology Data Exchange (ETDEWEB)

    Persaud, K. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1965-01-01

    We have carried out the synthesis of: - phenanthrene - its five monomethyl derivatives - three dimethyl derivatives - two trimethyl derivatives. We have then purified these products as well as a certain number of others obtained from various sources. We have been able to obtain in the majority of cases, a purity of 99.5 per cent or over, these figures being obtained by low voltage mass spectrometry. Finally we have recorded the infrared, ultraviolet, nuclear magnetic resonance and mass spectra of these products for which an atlas has been drawn up. (author) [French] Nous avons realise la synthese: - du phenanthrene - de ses cinq derives monomethyles - de trois de ses derives dimethyles - de deux de ses derives trimethyles. Nous avons ensuite purifie ces produits ainsi qu'un certain nombre d'autres que nous avons obtenus de sources differentes. Nous avons pu atteindre, dans la plupart des cas, une purete egale ou superieure a 99,5 pour cent, chiffres determines par la spectrometrie de masse a basse tension. Enfin, nous avons enregistre les spectres infrarouges, ultraviolets, de resonance magnetique nucleaire et de masse de ces produits dont nous avons fait un atlas. (auteur)

  6. Contribution to the study and use of ionisation chambers for nuclear reactor control (1965); Contribution a l'etude et a l'utilisation des chambres d'ionisation pour le controle des reacteurs nucleaires (1965)

    Energy Technology Data Exchange (ETDEWEB)

    Duchene, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1961-02-15

    high-power reactors. (author) [French] Les chambres d'ionisation sont actuellement les detecteurs les mieux adaptes au controle des reacteurs nucleaires par des mesures neutroniques. Nous avons cru bon de rappeler quelques generalites concernant la dynamique des reacteurs, les differents procedes de detection des neutrons, le fonctionnement des chambres d'ionisation et les methodes de mesure utilisees. Notre contribution aux techniques de controle des reacteurs consiste d'une part en une tentative de synthese des facteurs intervenant dans le fonctionnement des chambres d'ionisation, l'etude de ces facteurs, et d'autre part l'elaboration de chambres d'ionisation a fission et a bore permettant de suivre la marche d'un reacteur du demarrage jusqu'a la puissance maximale. Dans le domaine des chambres a fission, nous avons en particulier ameliore les techniques de depot d'oxyde d'uranium sur l'aluminium et realise la mise au point de depots par electrolyse sur d'autres metaux: acier inoxydable, cuivre, molybdene, nickel, tantale, titane, kovar, tungstene et beryllium. Nous avons elabore plusieurs types de chambres a fission servant au demarrage des reacteurs: un type de performances moyennes actuellement utilise dans les piles francaises un type a haute sensibilite un type a haute temperature qui a fonctionne jusqu'a 600 deg. C. En ce qui concerne les chambres a bore, nous avons etudie les perturbations apportees dans les mesures par l'exposition des chambres a d'importants flux de neutrons et a un rayonnement {gamma} intense. Cette exposition produit une modification des proprietes des materiaux constitutifs et la production dans les chambres d'un bruit de fond qui peut gener considerablement les mesures neutroniques. Nous avons montre que la technique de compensation permettait de limiter l'importance de ce bruit de fond et d'augmenter ainsi la plage de fonctionnement des

  7. Nuclear Safety Charter; Charte Surete Nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    The AREVA 'Values Charter' reaffirmed the priority that must be given to the requirement for a very high level of safety, which applies in particular to the nuclear field. The purpose of this Nuclear Safety Charter is to set forth the group's commitments in the field of nuclear safety and radiation protection so as to ensure that this requirement is met throughout the life cycle of the facilities. It should enable each of us, in carrying out our duties, to commit to this requirement personally, for the company, and for all stakeholders. These commitments are anchored in organizational and action principles and in complete transparency. They build on a safety culture shared by all personnel and maintained by periodic refresher training. They are implemented through Safety, Health, and Environmental management systems. The purpose of these commitments, beyond strict compliance with the laws and regulations in force in countries in which we operate as a group, is to foster a continuous improvement initiative aimed at continually enhancing our overall performance as a group. Content: 1 - Organization: responsibility of the group's executive management and subsidiaries, prime responsibility of the operator, a system of clearly defined responsibilities that draws on skilled support and on independent control of operating personnel, the general inspectorate: a shared expertise and an independent control of the operating organization, an organization that can be adapted for emergency management. 2 - Action principles: nuclear safety applies to every stage in the plant life cycle, lessons learned are analyzed and capitalized through the continuous improvement initiative, analyzing risks in advance is the basis of Areva's safety culture, employees are empowered to improve nuclear Safety, the group is committed to a voluntary radiation protection initiative And a sustained effort in reducing waste and effluent from facility Operations, employees and subcontractors are treated alike, and a high level Of know-how is supported by training and skills maintenance. 3 - Transparency and reporting: Areva endeavors to provide reliable and relevant information enabling an objective assessment of the status of nuclear safety in its facilities (incident reporting, annual report of the general inspectorate, annual reporting on occupational safety during nuclear facility operations). 4 - Glossary.

  8. Nuclear policy Council; Conseil de politique nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-02-09

    This document contains a set of statement about the French nuclear policy and the different measures and actions undertaken by the main actors of the nuclear sector (EDF, CEA, AREVA, and so on) and official bodies. Different topics are thus addressed: sector competitiveness, security and safety strengthening, works aimed at reactor life extension, costs of the electronuclear sector, installation safety complementary assessment, and evolution of the existing nuclear fleet

  9. The nuclear threat; La menace nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Tertrais, Bruno

    2011-01-26

    For a long time, a small group of big powers has been the only holder of nuclear weapons (US, USSR, Great Britain, France and China). Since then, new weapons have come out on the geopolitical scene: Israel, India, Pakistan, and some others remain uncertain and generate a worrying atmosphere (North Korea, Iran..). But what is the real risk with nuclear proliferation? Should we dread about it? Is nuclear terrorism a real threat? What are the political stakes of nuclear weapons? Is disarmament a real solution? These are some of the questions that the author answers in a precise and clear manner in this book. Contents: 1 - from monopoly to proliferation: who owns nuclear weapons today, why is it so coveted, is it easy to make one?; 2 - the newcomers: what do we really know about the Iranian nuclear programme, Iran and North Korea: between negotiation and confrontation; 3 - international control and regulation: do we have reliable information, how do we know what we know, Iraq: was there a 'lie' somewhere, who are the states who have renounced nuclear weapons?; 4 - the future: is there still a nuclear warfare risk, what if Pakistani weapons fall into islamic hands, is nuclear terrorism a fantasy or a real risk?

  10. Nuclear Magnetic Resonance imaging; Resonance magnetique nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Thibierge, M.; Sevestre, L.; Slupecki, P. [Centre Hospitalier de Charleville-Mezieres, 08 (France)

    1998-06-01

    After many years of low profile business in the USA, MRI is back. Improvements are focused on high field magnets and on low field magnets. The former, are dedicated to high quality imaging. The new scanners are more and more efficient because of the spreading use of real time imaging. They can do now, procedures that just could not be imagined some years ago. Vascular imaging is done routinely. Abdominal imaging in apnea of EPI, perfusion and diffusion imaging, and, last not least, all the field of functional imaging are on the verge of coming out. The new magnets unveiled in 1997 are lighter, smaller, more, user friendly, less impressive for patients subject to claustrophobia. They also need less helium to operate and less space to be sited. The latter, are dedicated to interventional procedures. The new magnets are wide opened and a lot of companies show off. Though Picker unveiled a new light superconductive 0.5 Tesla magnet, it seems that this kind of machines are about to disappear. No significant progress was noticed in the field of dedicated MRI devices. Some features can be highlighted: the new Siemens short bore and its table integrates the Panoramic Array Coil Concept. It will allow simultaneous scanning with up to four coils; the excellent homogeneity of the new Picker magnet that will allow spectroscopy at 1 Tesla; the twin gradients of the Elscint Prisma that will open the field of microscopy MRI; the Philips `floppy gradients` that could speed up 4 or 6 times, the time needed for imaging; some new sequences sensitive to temperature are studied as WIP; a lot of work is achieved on 3 or 4 Tesla scanners etc. (author)

  11. Nuclear Safety. 1997; Surete Nucleaire. 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-19

    A quick review of the nuclear safety at EDF may be summarized as follows: - the nuclear safety at EDF maintains at a rather good standard; - none of the incidents that took place has had any direct impact upon safety; - the availability remained good; - initiation of the floor 4 reactor generation (N4 unit - 1450 MW) ensued without major difficulties (the Civaux 1 NPP has been coupled to the power network at 24 december 1997); - the analysis of the incidents interesting from the safety point of view presents many similarities with earlier ones. Significant progress has been recorded in promoting actively and directly a safe operation by making visible, evident and concrete the exertion of the nuclear operation responsibility and its control by the hierarchy. The report develops the following chapters and subjects: 1. An overview on 1997; 1.1. The technical issues of the nuclear sector; 1.2. General performances in safety; 1.3. The main incidents; 1.4. Wastes and radiation protection; 2. Nuclear safety management; 2.1. Dynamics and results; 2.2. Ameliorations to be consolidated; 3. Other important issues in safety; 3.1. Probabilistic safety studies; 3.2. Approach for safety re-evaluation; 3.3. The network safety; 3.4. Crisis management; 3.5. The Lifetime program; 3.6. PWR; 3.7. Documentation; 3.8. Competence; 4. Safety management in the future; 4.1. An open future; 4.2. The fast neutron NPP at Creys-Malville; 4.3. Stabilization of the PWR reference frame; 4.4. Implementing the EURATOM directive regarding the radiation protection standards; 4.5. Development of biomedical research and epidemiological studies; 4.6. New regulations concerning the liquid and gaseous effluents; 5. Visions of an open future; 5.1. Alternative views upon safety ay EDF; 5.2. Safety authority; 5.3. International considerations; 5.4. What happens abroad; 5.5. References from non-nuclear domain. Four appendices are added referring to policy of safety management, policy of human factors in NPPs, technical incidents, and human factor incidents.

  12. The Fukushima accident; Accident nucleaire a Fukushima

    Energy Technology Data Exchange (ETDEWEB)

    Delbecq, D.

    2012-02-15

    The Fukushima accident is characterized by a sequence of natural disasters: earthquake and tsunamis that deprived simultaneously 3 reactors from cooling and electrical power for quite a long time. A series of hydrogen explosion has added to the mess. Experts agree to say that certainly nuclear fuel has melt to form corium in all 3 reactors. The accident has contaminated tens of thousand acres of land around the plant and has jeopardized local coastal fishery. The human toll is unexpectedly low: no direct casualty in the population but several suicides among the people that was forced to leave their home. 5 people from the plant staff died certainly from the consequences of the tsunami. (A.C.)

  13. Nucleaire et Energies Nr 66 - July 2015

    International Nuclear Information System (INIS)

    Lenail, Bernard; Ducroux, Guy; Salanave, Jean-Luc; Seyve, Claude; Simonnet, Jacques; Justin, Francois; Darricau, Aime; Raisonnier, Daniele

    2015-07-01

    After a first article recalling the creation of Areva and difficulties faced by this company which resulted in some kind of backward step, two articles address evolutions in the energy sector: an overview of recent evolutions (USA to become the first oil producer in the world, the OPEC policy, the distribution of nuclear energy production in the world, world consumption in 2014, the French law on energy transition, the dilemma associated with energy transition in Germany, regulated gas prices in France), and a discussion of the perspective for electricity by 2050 (100 per cent renewable? And why not 100 per cent nuclear?). Four articles concern nuclear activities: recent events in the mining and fuel fabrication sectors (an uranium bank in Kazakhstan, contract for Areva in Ukraine, uranium enrichment in South Korea, Saudi Arabia, India, China, Japan, USA), recent events regarding nuclear reactors (in France, UK, Sweden, Czech Republic, Russia, Turkey, South Korea), overview of activities and events related to the back-end of the fuel cycle (in France, Germany, China, USA and Japan), and a presentation of Savannah River MFFF plant (MOX Fuel Fabrication Facility). Two article address issues related to nuclear and society: a discussion on the possibility to eat irradiated food products, and the issue of the Iranian nuclear industry with respect to non-proliferation. A last article briefly discusses some terminological confusion between energy and electricity, and between produced energy and available power

  14. Nuclear reactor (1960); Reacteurs nucleaires (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Maillard, M.L. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires; Leo, M.B. [Electricite de France (EDF), 75 - Paris (France)

    1960-07-01

    The first French plutonium-making reactors G1, G2 and G3 built at Marcoule research center are linked to a power plant. The G1 electrical output does not offset the energy needed for operating this reactor. On the contrary, reactors G2 and G3 will each generate a net power of 25 to 30 MW, which will go into the EDF grid. This power is relatively small, but the information obtained from operation is great and will be helpful for starting up the power reactor EDF1, EDF2 and EDF3. The paper describes how, previous to any starting-up operation, the tests performed, especially those concerned with the power plant and the pressure vessel, have helped to bring the commissioning date closer. (author) [French] Les premiers reacteurs industriels plutonigenes francais G1 - G2 - G3 du Centre de Marcoule comportent une installation de recuperation d'energie. La production d'electricite de G1 ne compense pas l'energie depensee par ailleurs pour le fonctionnement de l'ensemble, par contre, G2 et G3 doivent fournir chacun une puissance de 25 a 30 MW au reseau national d'Electricite de France. Cette puissance est modeste, mais l'experience acquise grace a ces reacteurs est tres grande et c'est grace a elle qu'il nous sera possible de mettre en exploitation les reacteurs energetiques EDF1 - EDF2 - EDF3. Le memoire decrit comment, avant tout demarrage du reacteur, les essais effectues, en particulier ceux concernant l'installation de recuperation d'energie et le caisson, ont permis d'abreger la phase de montee en puissance. (auteur)

  15. Nucleaire et Energies Nr 68 - June 2016

    International Nuclear Information System (INIS)

    Lenail, Bernard; Ducroux, Guy; Seyve, Claude; Simonnet, Jacques; Dupont, Jean-Francois; Salanave, Jean-Luc; Justin, Francois; Greneche, Dominique; Lepine, Gerard; Raisonnier, Daniele

    2016-06-01

    After a first article which comments the situation of EDF which is a serious matter of concern, notably due to the current context for the energy sector and market, and which notably comments the issue of the Hinkley Point project, an article proposes an overview of recent evolutions (oil price recent evolutions, perspectives for gas and coal, the abundance and availability of hydroelectric energy). Three articles concern nuclear activities: recent events about reactors (EU policy, decisions, projects and events in Switzerland, Sweden, UK about Hinkley Point, Fessenheim, Chernobyl, Poland, Europe about reactor lifetime extension, Russia, in Saudi Arabia and South Korea about the Korean APR-1400 technology, in Bangladesh, in India, Japan and USA), about the back-end of the fuel cycle and decommissioning activities (brief focus on the Cigeo project, foreign storages, discussion of the warehousing-transport issue, dismantling activities in France, recycling in France, Russia, China, Taiwan and the UK, evolution of the MFFF plant in Savannah River), and a comment of the main qualities of nuclear energy. Articles comment issues concerning the relationship between nuclear and society with a comment on the French approach (nuclear and precaution principle, anti-nuclear position of French media, crucial role of operators for nuclear safety), and a comment on the evolution of human lifetime expectation statistics in France and its possible relationship with technology when taking accidents related to energy sources into account. An article analyses the German situation with respect to energy. A last article briefly discusses some terminological confusion between energy and electricity, and between produced energy and available power

  16. Nuclear wastes management; Gestion des dechets nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    This document is the proceedings of the debate that took place at the French Senate on April 13, 2005 about the long-term French policy of radioactive wastes management. The different points tackled during the debate concern: the 3 axes of research of the 1991 law, the public acceptance about the implementation of repositories, the regional economic impact, the cost and financing, the lack of experience feedback, the reversibility or irreversibility of the storage, the share of nuclear energy in the sustainable development policy, the European Pressurized Reactor (EPR) project, the privatization of Electricite de France (EdF) etc. (J.S.)

  17. The nuclear refugees; Les refugies du nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Linton, M.

    2011-06-15

    The authors propose a report on the various situations of people who had to be evacuated after the Fukushima accident. Along with examples of people who left their homes with taking with them a single object, the authors describe and comment how this evacuation occurred, the problems faced by the authorities for refugee reception and accommodation. This evacuation has been either organised or spontaneous. Hospitals had to be evacuated as well. Then, local authorities faced food shortage. Some animals have been saved, other starved to death. Dead animals are covered with lime. Dead bodies are decontaminated before being given back to families. Tests are regularly performed to assess people contamination. A second article discussed the bad news concerning the different Fukushima reactors with their melted cores. The geophysical aspects of the earthquake are evoked in a last article

  18. Contribution to the experimental survey of the nuclear isomerism. Application of the deferred coincidences method to research and to the survey of metastable states of short period; Contribution a l'etude experimentale de l'isomerie nucleaire. Application de la methode des coincidences differees a la recherche et a l'etude d'etats metastables de periode courte

    Energy Technology Data Exchange (ETDEWEB)

    Ballini, R. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1953-06-15

    Various methods of the physics brought many informations on the nuclear elements which one can arrange some ponderable quantities, what is the case of the steady elements and some, unsteady elements, as most of natural radioelements. On the other hand, elements of shorter life duration, and notably those that are carried to an excited state, are more badly known, and one can get information to their consideration that by the mediator of the properties of the transitions that they undergo, when they give birth has best-known nuclear cash: among these transitions represent the isomeric transitions. The goal of this work is the survey of the isomeric transitions from metastable states of short period, included in the domain of the microsecond to some milliseconds. The method of the deferred coincidences has been put to the point and applied in this goal while using the advantages of the selectors to several channels, under two main aspects where the device to several channels was either a selector of time, either a selector of amplitudes. This method served to study the working of Geiger-Muller counter and to measure with precision the period of {sup 181}Ta{sup *} in of the varied experimental conditions. The adopted value is 17,2 {+-}0,2 {mu}s. This work also found an immediate practical application to the setting in evidence of very weak quantities of hafnium in zirconium, of which it constitutes a tenacious and difficult impurity to analyze by the ordinary ways. (M.B.) [French] Les diverses methodes de la physique ont apporte de nombreux renseignements sur les especes nucleaires dont on peut disposer en quantites ponderables, ce qui est le cas des especes stables et de certaines especes instables, comme la plupart des radioelements naturels. Par contre, les noyaux de duree de vie plus courte, et notamment ceux qui sont portes a un etat excite, sont plus mal connus, et on ne peut obtenir de renseignements a leur egard que par l'intermediaire des proprietes des

  19. Advice of the French nuclear safety authority concerning the researches relative to the management of high activity and long lived radioactive wastes as carried out in the framework of the December 30, 1991 law, and links with the national plan of management of radioactive wastes and valorizable materials (PNGDR-MV); Avis de l'Autorite de Surete Nucleaire sur les recherches relatives a la gestion des dechets a haute activite et a vie longue (HAVL) menees dans le cadre de la loi du 30 decembre 1991, et liens avec le PNGDR-MV

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-02-15

    This document reports on the main conclusions of the French nuclear safety authority (ASN) after 15 years of researches on radioactive wastes management carried out in the framework of the law 91-1381 from December 30, 1991. The advice of the ASN is not limited to the high level and long lived radioactive wastes. It presents first the dispositions of the December 30, 1991 law which fixes the main trends of the researches on radioactive waste management. Then it recalls the role of the ASN and of its technical means in the three axes of research (separation-transmutation, conditioning and long-duration storage, disposal in deep geologic formation): safety at all waste management steps, management consistency for all waste-types, development of suitable processes for each category of waste. The position of the ASN with respect to each axis of research is detailed and some recommendations and additional information needs are expressed. A schedule is proposed for the implementation of a storage facility in the argilite formation near the Bure site. Then it refers to the implementation of a national plan of management of radioactive wastes and valorizable materials, in particular concerning the low level and long lived wastes, the used sealed sources, the tritiated wastes and the naturally radioactive wastes (uranium mine tailings). (J.S.)

  20. Order of the 29. of January 2010 approving the decision n. 2009-DC-0146 made on the 16. of July 2010 by the Nuclear Safety Authority (ASN), modified by the decision n. 2009-DC-0162 of the 20. of October 2009, defining the list electric equipment generating X rays which are hold or used for purposes of biomedical research or medical, dental, forensics or veterinary diagnosis and submitted to a declaration regime on the account of the first paragraph of the article R. 1333-19 of the Public Health code and abrogating the 23 April 1969 order related to equipment and installations using ionizing radiations on medical purposes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This legal document indicates the list of equipment which must now be declared to the ASN (the French Nuclear Safety Authority), specifies that any use of these equipment in conditions other than normal requires an authorization on the account of an article of the Public Health Code. A list of equipment is given which are used in medical and forensics radio-diagnosis, in biomedical research, in dental and veterinary radio-diagnosis

  1. Contribution to the study of time-resolution in pulse electronics for nuclear physics: phase control circuits; Contribution a l'etude de la resolution en temps de l'electronique impulsionnelle pour physique nucleaire: les circuits de mise en phase

    Energy Technology Data Exchange (ETDEWEB)

    Cortet, J.P. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-07-01

    Phase control circuits make it possible to improve quite markedly the time resolution in pulse electronics. They replace a random pulse, of which the time of arrival with respect to a reference zero is being measured, by another pulse whose phase is well determined with respect to that, of a clock taken as reference. The time spectrum of the output, delayed, can always be situated inside channels of width {delta}T defined by the clock. The time statistics of the events analyzed is always correct even if the transition time for the circuits defining the channels represents a large fraction of {delta}T: the coding of the time becomes perfect, The phase control circuits, used in precision chronometry, are widely applied in Nuclear Physics since the lime spectra obtained are representative, indirectly, of certain values which are required to be measured with great accuracy. A description is given of: the constitution and operation of phase control circuits; a chain with automatic analysis and automatic reading, built for testing these circuits. Finally the measurement results are given. (author) [French] Les circuits de mise en phase permettent d'ameliorer notablement la resolution en temps de l'electronique impulsionnelle. Ils substituent a une impulsion aleatoire, dont on cherche a mesurer l'instant d'arrivee par rapport a un instant pris pour origine, une autre impulsion dont la phase est bien determinee par rapport a celle d'une horloge prise comme reference. Le spectre temporel de sortie, retarde, peut toujours etre situe a l'interieur des canaux de largeur {delta}T, definis par l'horloge. La statistique temporelle des evenements analyses est toujours correcte, meme si la duree de transition des circuits definissant les canaux represente une grande fraction de {delta}T: le codage de temps devient parfait. Les circuits de mise en phase, utilises en chronometrie fine, sont tres employes en Physique Nucleaire car les spectres

  2. Applying the International Nuclear Event Scale to radioactive materials transport events

    International Nuclear Information System (INIS)

    Krembel, D.

    2002-01-01

    Expanding the scope of its activities to include controlling the safe transport of radioactive materials, the French Nuclear Safety Authority (ASN) has decided to apply the INES scale to transport events, following a wide-ranging debate bringing together experts, industry and the Conseil Superieur de la Surete et de l'Information Nucleaire (Higher Council for Nuclear Safety and Information). International interest in French experience has gradually raised the question of harmonised application of the INES scale to transport events by the competent international authorities. (author)

  3. Vitalita současné galicijštiny

    OpenAIRE

    Picková, Lenka

    2014-01-01

    Mgr. Lenka Picková Vitality of the current Galician language Abstract: Never in the field of human history has the dying out of languages been as intense as it is in the present day. The goal of this paper is to assess the vitality of the one of the co- official languages in Spain, the Galician language. After an indispensable definition of the social-historical context, a deep, qualitative and quantitative analysis of nine factors is performed: inter-generational language transmission, educa...

  4. Současný pohled na koenzym Q

    Czech Academy of Sciences Publication Activity Database

    Rauchová, Hana; Vokurková, Martina

    2009-01-01

    Roč. 103, č. 1 (2009), s. 32-39 ISSN 0009-2770 R&D Pro jects: GA MŠk(CZ) 1M0510 Institutional research plan: CEZ:AV0Z50110509 Keywords : coenzyme Q * mitochondria * dietary supplement Subject RIV: CE - Biochemistry Impact factor: 0.717, year: 2009

  5. Lessons learned from the ASN Renal Educator Listserv and survey.

    Science.gov (United States)

    Hoenig, Melanie P; Shapiro, Evelyn; Hladik, Gerald A

    2013-06-01

    Nephrology ranks next to last in career choices among US medical school graduates. The American Society of Nephrology established a Workforce Committee to help address this issue. Surveys of US medical students indicate that experiences during kidney pathophysiology courses in the preclerkship years may impact their decision to consider a career in nephrology. In October of 2011, preclinical kidney physiology and pathophysiology course directors at US medical schools were surveyed about teaching methods, curricular content, resources, and institutional support for teaching to identify what worked well and what impairs their teaching efforts. A Listserv of these educators, the American Society of Nephrology Renal Educators Listserv, was used to electronically administer the survey. Course leaders from 62 of 114 (54.4%) surveyed medical schools responded. Most of these educators are nephrologists, but physiologists and other clinicians also lead courses; 60% of course directors noted that lectures are videotaped, resulting in decreased attendance. A range of resources is used: 68% use audience response systems, 16% use the simulation center, and none of the educators indicated use of social media (such as Twitter or Facebook); 50% of respondents receive no remuneration, and 68% receive no full-time equivalent for their efforts. Audience response systems, virtual microscopy, and flash animations were identified as valuable teaching tools. Course directors, during subsequent dialogue on the American Society of Nephrology Renal Educators Listserv, have cited incorporation of case scenarios and integration of clinical exposure during preclinical years as methods that inspired interest. Hopefully, adoption of such approaches will ultimately serve to stimulate interest in nephrology.

  6. Effect of cobalt-60 {gamma} radiation and of thermal neutrons on high resistance P and N silicon. Possibility of obtaining a nuclear compensation for P type silicon; Effects du rayonnement {gamma} du cobalt 60 et de neutrons thermiques sur du silicium P et N de haute resistivite. Possibilite de realiser une compensation nucleaire d'un silicium du type P

    Energy Technology Data Exchange (ETDEWEB)

    Messier, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1965-11-01

    Type P silicon has been compensated by the production of a controlled and uniform amount of donor atoms ({sup 31}P) using thermal neutrons to bring about a nuclear transformation. It is shown that it is possible in this way to reduce by a factor of about one hundred the overall concentration of residual ionised impurities in the purest crystals obtained by floating zone purification (2 x 10{sup 12} atoms/cm{sup 3}). The degree compensation obtained is limited by the initial inhomogeneity of acceptor impurities which have to be compensated. Lattice defects which still remain after prolonged annealings reduce the life-time of the material to about 10 {mu}s approximately. Particle detectors having thicknesses of 2 to 5 mm have been built by this process; they give good results, particularly at low temperatures. A study has also been made of the number and of the nature of lattice defects produced by thermal neutrons in high resistivity P and N type crystals. These defects have been compared to those produced by {gamma} rays from {sup 60}Co. A discussion is given of the validity of the Wertheim model concerning pronounced recombination at low temperatures (77 deg. K - 300 deg. K) of primary defect-interstitial pairs. The nature of the defects introducing energy levels into the lower half of the forbidden band has been studied. (author) [French] On a compense du silicium de type P en produisant, au moyen de neutrons thermiques, par transmutation nucleaire une quantite controlee et uniforme d'atomes donneurs ({sup 31}P). On montre qu'on peut ainsi reduire de cent fois environ la densite nette d'impuretes ionisees residuelles subsistant dans les cristaux les plus purs obtenus par purification par zone flottante (2.10{sup 12} atomes/cm{sup 3}). Le degre de compensation obtenu est limite par i'inhomogeneite initiale des impuretes acceptrices a compenser. Des defauts de reseau qui subsistent meme apres des recuits prolonges reduisent la duree de vie du

  7. Technical dialogue with the civil society : anomalies in steel composition for the EPR reactor vessel and EDF reactor steam generators : Meeting of the 2 December 2015 - Stakes of EPR vessel justification approach; Meeting of the 6 April 2016 - ASN position letter on the justification approach presented by Areva as well as on the representativeness of sacrificial parts; Meeting of the 15 September 2016 - Anomalies of fabrication of forged parts, controls performed on the fabrication of the Flamanville 3 vessel, evolutions of the justification approach

    International Nuclear Information System (INIS)

    Audige, Joel; Autret, Jean-Claude; Baron, Yves; Clar, Robert; Correa, Alain; Demet, Michel; Gaillard, Pierre; Lacote, Jean-Paul; Lepetit, Jacques; Luce, Patrick; Lunel, Emmanuel; Rousselet, Yannick; Copin, Andre; Sene, Monique; Catteau, Remy; Collet, Julien; Fasulo, Celine; Cadet-Mercier, Sylvie; Lebeau-Live, Audrey; Leroyer, Veronique; Loiseau, Olivier; Payen, Thierry; Rollinger, Francois; Schuler, Matthieu; Pertuisot, Marie-Helene; Besnard, Manon; Marignac, Yves; Boilley, David; De L'Epinois, Bertand; Pochitaloff, Pierre; Viers, Stephanie; Sene, Raymond; Demet, Valerie; Gazal, Suzanne; Lheureux, Yves; Fossard, Jean-Luc; Lacote, Jean-Paul; Noe, Maite; Blavette, Guillaume

    2015-01-01

    This document gathers meeting reports and Power Point presentations made during a set of meetings organised by the IRSN to establish a technical dialogue between the ASN, the national association of local information committees and commissions (ANCCLI) and the Flamanville local information commission (CLI), in order to give access to the expertise on the anomaly noticed on the chemical composition of the steel used for the Flamanville EPR reactor vessel in its cover and bottom parts. The first meeting comprised an introduction, a presentation of the Flamanville 3 EPR vessel and covers, a history of their elaboration and certification approaches. The test programme implemented for these covers and the regulatory framework are also addressed, and the justification approach is discussed. Exchanges and debates are also reported. The second meeting comprised the presentation of letters issued by the ASN, a presentation of tests performed on sacrificial parts, a presentation of operation planning and progress, and debates on these issues. The third meeting proposed a focus on fabrication anomalies, a presentation of controls performed during vessel fabrication (by Areva, by EDF, and others), and a presentation of the evolution of the approach adopted by Areva to justify covers of the EPR vessel

  8. Authorization Decree Application for the creation of the Flamanville-3 Basic Nuclear Installation. Executive Summary of the Technical Review

    International Nuclear Information System (INIS)

    2009-01-01

    On 9 May 2006, Electricite de France (EDF) submitted to the Ministers for Nuclear Safety an authorization decree application for an EPR-type reactor on the site of the Flamanville Nuclear Power Plant (NPP). Article 29 of Act No. 2006-686 of 13 June 2006 on Transparency and Security in the Nuclear Field prescribes that the creation of any basic nuclear installation shall be issued by a decree taken after consultation with the Nuclear Safety Authority (Autorite de surete nucleaire - ASN). The purpose of this report is to provide ASN's Board with a summary of the technical review led by ASN services and carried out by their technical support agencies, namely the IRSN, the GPR and the Standing Nuclear Section of the CCAP between 2001 and 2006. After summing up the conclusions of the review on the safety options of the European Pressurized Reactor (EPR) Project, as carried out between 1993 and 2000, this report describes the process and modalities of the review conducted from 2001 to 2006. Besides providing the opinion of ASN's services on the creation-licence application, it also outlines the further review to be carried out, if the authorization decree is issued. (authors)

  9. Nuclear, phantasm and emotions; Nucleaire, fantasmes et emotions

    Energy Technology Data Exchange (ETDEWEB)

    Michel, A

    2009-03-15

    Nuclear energy as it appears in novels and films gives an image that can influence our judgment. If the phantasms amplified by the antinuclear groups can influence the public opinion, so the communication on the nuclear subjects must be more emotional to touch the general public. Through different images carried in comic books or in fiction novels it is the anxiety that is privileged. If nuclear industry must propose a rational and well informed approach that gives value to its experience, this must not prevent to consider a more emotional perspective. (N.C.)

  10. The 9. European nuclear conference; La 9. conference nucleaire europeenne

    Energy Technology Data Exchange (ETDEWEB)

    Maurel, V.; Lewis, D.; Smirnov, V.P.; Gutierrez, J.E.; Paulin, Ph.; Markov, D.V.; Smirnov, A.V.; Polenok, V.S.; Horhoianu, G.; Olteanu, G.; Van der Schaaf, B.; Gavillet, D.; Lapena, J.; Ohms, C.; Roth, A.; Van Dyck, St.; Mardon, J.P.; Thomas, A.; Cipiere, M.F.; Faidy, C.; Hedin, F.; Delnondedieu, M.; Chassignole, B.; Doudet, L.; Dupond, O.; Kang, K.; Park, K.; Kim, K.; Ha, J.; Hoon-Seok, Jung; Yong-koo, Lee; Kwang-Ho, Kim; Seungwoo, Paek; Heui-Joo, Choi; Do-Hee, Ahn; Kwang-Rag, Kim; Minsoo, Lee; Sung-Paal, Yim; Hongsuk, Chung; Detroux, P.; Meessen, O.; Defloor, J.; Lars-Erik, Holm; Barescut, J.C.; Vacquier, B.; Laurier, D.; Caer, S.; Quesne, B.; Oudalova, A.; Geras' kin, St.; Dikarev, V.; Dikareva, N.; Chernonog, E.; Yang-Geun, Chung; Gab-Bock, Lee; Sun-Young, Bang; Yong-Sun, Lee; Bolognese-Milsztajn, T.; Frank, D.; Lacoste, V.; Pihet, P.; Lacronique, J.F.; Chauliac, C.; Verwaerde, D.; Pavageau, O.; Zaetta, A.; Varaine, F.; Warin, D.; Hudelot, J.P.; Bioux, Ph.; Klann, R.; Petruzzi, A.; D' auria, F.; Yung Kwon, Jin; Chul Jin, Chol; Mihalache, M.; Radu, V.; Pavelescu, M.; Schneidesch, Ch.R.; Jinzhao, Zhang; Dalleur, J.P.; Nuttin, A.; Meplan, O.; Wilson, J.; Perdu, F.; Campioni, G.; Mounier, C.; Sigrist, J.F.; Laine, Ch.; Broc, D.; Robbe, M.F.; Cariou, Y.; Seok-Kyun, Yoon; Win, Naing; Myung-Hyun, Kim; Kyung, Hee; Fridman, E.; Shwageraus, E.; Galperin, A.; Meplan, O.; Laulan, O.; Mechel-Sendis, F.; Belgaid, M.; Kadem, F.; Amokrane, A.; Hamidouche, T.; El-Khider, Si-Ahmed

    2005-11-15

    This issue gathers the abstracts of the papers presented at the ninth European nuclear conference (ENC-2005). The main part of the conference is split into 20 sessions. These sessions cover all technical aspects of nuclear power, from reactor design to waste management, without forgetting experimental and research reactors, reactor dismantling, economy, resources, safety, radioprotection and education issues. Perspectives of a nuclear renaissance are clearly visible in the world. This renaissance, mainly due to political, economical, societal and ecological factors, is fuelled by scientific and technical progress. This conference was the opportunity to present together these aspects of nuclear power and to analyze their mutual interactions.

  11. Nuclear: how to get off?; Nucleaire: comment en sortir?

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    This study aims to propose actions to get off the nuclear in less than 10 years. The first part is devoted to the energy efficiency: the energy produced by the today electric network, the energy conservation in the ternary, industrial and residential sector. The second part presents an offer of electricity without the nuclear: the renewable energies, the fossil energies, the carbon tax and the nuclear park closure. (A.L.B.)

  12. Bescherming tegen de gevolgen van de nucleaire elektromagnetische impuls

    NARCIS (Netherlands)

    Möhring, F.; Sevat, P.A.A.

    1972-01-01

    Protection against the effects of the nuclear electromagnetic pulse. A nuclear explosion generates a short impulsive electromagnetic field which propagates over the earth radially from the point of explosion. In the explosion zone the electric and magnetic fieldstrengths are high and may damage

  13. Ovarian psammocarcinoma and nuclear medicine; Psammocarcinome ovarien et medecine nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Chalaye, J.; Razzouk-Cadet, M.; Carrier, P.; Girma, A.; Koulibaly, P.M.; Darcourt, J. [Federation inter-hospitaliere, CHU-CAL universitaire de Nice, (France); Cambefort, P. [service de medecine nucleaire, CHU Augustin-Morvan, Nice, (France); Bereder, J.M. [service universitaire de chirurgie digestive, hopital de l' Archet, Nice, (France); Chaborel, J.P. [centre imagerie nucleaire, Mougins, (France)

    2009-05-15

    The calcification of tumors injuries at the T.D.M. is a good indicator of psammoma serous carcinoma. The psammoma injuries fix the {sup 18}F.D.G. at the level of their tumor part and the technetium osseous tracers at the level of their calcified part; They are easily identifiable in nuclear medicine what is useful in the measure where the psammoma serous ovarian carcinoma benefits of a prognosis relatively better than this one of serous ovarian adenocarcinoma. (N.C.)

  14. Ovarian psammocarcinoma and nuclear medicine; Psammocarcinome ovarien et medecine nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Razzouk-Cadet, M.; Carrier, P.; Girma, A.; Koulibaly, P.M.; Darcourt, J. [CHU-CAL Universitaire de Nice, Hopital de l' Archet, Service Universitaire de Medecine Nucleaire, Centre TEP, Federation inter-hospitaliere, 06 - Nice (France); Cambefort, P. [CHU Augustin-Morvan, Service de Medecine Nucleaire, 29 - Brest (France); Bereder, J.M. [Hopital de l' Archet, Service Universitaire de Chirurgie Digestive, 06 - Nice (France); Chaborel, J.P. [Centre Imagerie Nucleaire, 06 - Mougins (France)

    2009-02-15

    We report three cases of ovarian psammocarcinoma, which is a serous adenocarcinoma having psammoma calcifications. The F.D.G. uptake in the psammomatous lesions is due to the tissular part of the lesion and the {sup 99m}Tc labelled agents uptake to its calcified part. Calcifications are detected on CT scans. Therefore, they are relatively simple to diagnose by nuclear medicine which is useful given relatively the better prognosis of the psammomatous ovarian serous carcinoma when compared to the serous one. (authors)

  15. Overview of the Russian nuclear industry; Le panorama nucleaire russe

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-02-15

    In 2004, President Poutine decided to replace the atomic energy ministry (Minatom) by the federal atomic energy agency (Rosatom). Several projects were launched during the next two years which aimed at bringing back Russia to the fore front of the world leaders of nuclear energy use and nuclear technology export. In 2007, Rosatom agency was changed to a public holding company and a new company, named Atomenergoprom, was created which gathers all civil nuclear companies (AtomEnergoMash for the exploitation of power plants, Technabsexport (Tenex) specialized in enrichment or Atomstryexport in charge of export activities). Thus, Rosatom is at the head of all civilian and military nuclear companies, of all research centers, and of all nuclear and radiological safety facilities. In 2006, Russian nuclear power plants supplied 15.8% of the whole power consumption. Russia wishes to develop its nuclear program with the construction of new reactors in order to reach a nuclear electricity share of 25% from now to 2020. This paper presents first the 2007 institutional reform of the Russian atomic sector, and the three sectorial federal programmes: 1 - development of the nuclear energy industrial complex for the 2007-2010 era and up to 2015 (future power plants, nuclear fuel centers and reactor prototypes), 2 - nuclear safety and radioprotection for the 2008-2015 era (waste management, remedial actions, radiation protection), 3 - military program (confidential). Then, the paper presents: the international actions (export of Russian technology, cooperation agreements, non-proliferation), the situation of the existing nuclear park (reactors in operation, stopped, under construction and in project), the fuel cycle activities (production of natural uranium, enrichment, fuel fabrication, spent fuel storage, reprocessing, waste management), the nuclear R and D in Russia, and the nuclear safety authority. (J.S.)

  16. The nuclear: a clean energy; Le nucleaire: une energie propre

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    At the beginning the Nuclear Energy was developed in a context of energy diversification and competitiveness. Today another of its assets shows the interest of this energy source: the nuclear energy is a clean energy which controls the wastes and offers an efficient solution against the atmospheric pollution and the climatic change. These two arguments are developed. (A.L.B.)

  17. Graphites for nuclear applications; Les graphites pour les applications nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Bonal, J.P.; Gosmain, L. [CEA Saclay, Dept. des Materiaux pour le Nucleaire (DMN), Lab. de Microscopie et d' Etudes de l' Endommagement, 91 - Gif-sur-Yvette (France)

    2006-03-15

    Being an excellent neutron moderator, graphite is used as a structural material in many nuclear reactor types. By the end of the 50's, the French gas-cooled reactor development needed manufacturing of a nuclear-grade graphite. Graphite irradiation can lead to in-lattice energy accumulation, dimensional changes and physical properties modification. Moreover, the radiolytic corrosion induced by the coolant (CO{sub 2}) may generate mechanical properties degradation. Today, French gas-cooled reactors are all in their decommissioning phase that requires the knowledge of the radiological inventory of the irradiated graphites. At present time, graphite is still foreseen as a future material for hydrogen production by high temperature gas cooled nuclear plants. In the future, graphite will be the necessary moderator material for high temperature reactors with thermal neutron spectrum dedicated to hydrogen and electricity production. (authors)

  18. Energy: nuclear energy; Energies: l'energie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Lung, M. [Societe Generale pour les Techniques Nouvelles (SGN), 78 - Saint-Quentin-en-Yvelines (France)

    2000-11-01

    Convinced that the nuclear energy will be the cleaner, safer, more economical and more respectful of the environment energy of the future, the author preconizes to study the way it can be implemented, to continue to improve its production, to understand its virtues and to better inform the public. He develops this opinion in the presentation of the principal characteristics of the nuclear energy: technology, radioactive wastes, radiation protection, the plutonium, the nuclear accidents, the proliferation risks, the economics and nuclear energy and competitiveness, development and sustainability. (A.L.B.)

  19. EPR: the nuclear impasse; EPR: l'impasse nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Marillier, F. [Association Ecologiste Greenpeace (France)

    2008-07-01

    The questions relative to the climatic change constitute crucial challenges for the next ten years. In this context the author aims to show how the EPR project illustrates the nuclear french ''autism''. He presents and analyzes the international and environmental impacts of this obsolete technology, as a project useless and dangerous. (A.L.B.)

  20. The nuclear energy; Elements sur l'energie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Leconte, Ph [CEA Saclay, Dir. du Developpement et de l' Innovation Nucleaires (DEN/DDIN), 91 - Gif Sur Yvette (France)

    2001-08-15

    This paper is the lesson provided by the author at the physics summer school. After a recall on the atoms nuclei properties, he explains the nuclear reactor principle, their stability and safety. The fuel cycle is also detailed as the different reactors technologies. The last part deals with the thermonuclear fusion. (A.L.B.)

  1. INIS, CEA and nuclear terminology; INIS, CEA et terminologie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Surmont, J.; Brulet, C.; Constant, A.; Guille, N.; Le Blanc, A.; Mouffron, O.; Anguise, P.; Jouve, J.J

    2007-07-01

    This poster, prepared for the fifth edition of the meetings of scientific and technical information professionals (RPIST, Nancy (France)), presents, first, the INIS information system, its content and coverage, the French participation to this system and the role of the CEA-Saclay as France's official representative for this system. Then it presents the INIS thesaurus with its different levels as a terminological tool for the indexing of documents and for searching documents inside the database. Finally, the very first electronic version of the multilingual thesaurus is introduced. Several national INIS centres, including the CEA-Saclay, have contributed to the translation of lists of new terms and of forbidden terms (synonyms). (J.S.)

  2. Nuclear and sustainable development; Nucleaire et developpement durable

    Energy Technology Data Exchange (ETDEWEB)

    Audebert, P.; Balle, St.; Barandas, Ch.; Basse-Cathalinat, B.; Bellefontaine, E.; Bernard, H.; Bouhand, M.H.; Bourg, D.; Bourgoignon, F.; Bourlat, Y.; Brunet, F.; Buclet, N.; Buquet, N.; Caron, P.; Cartier, M.; Chagneau, E.; Charles, D.; Chateau, G.; Collette, P.; Collignon, A.; Comtesse, Ch.; Crammer, B.; Dasnias, J.; Decroix, G.; Defoy, B.; Delafontaine, E.; Delcroix, V.; Delerue, X.; Demet, M.; Dimmers, G.; Dodivers, S.; Dubigeon, O.; Eimer, M.; Fadin, H.; Foos, J.; Ganiage, D.; Garraud, J.; Girod, J.P.; Gourod, A.; Goussot, D.; Guignard, C.; Heloury, J.; Hondermarck, B.; Hurel, S.; Jeandron, C.; Josse, A.; Lagon, Ch.; Lalleron, Ch.; Laurent, M.; Legrand, H.; Leveau, E

    2006-07-01

    On September 15. and 16., 2004, at Rene Delcourt invitation, President of the C.L.I. of Paluel and Penly, took place the 4. colloquium of the A.N.C.L.I.. Jean Dasnias, new President of the C.L.I., welcomed the colloquium. Hundred of persons participated. The place of the nuclear power in the energy perspectives of tomorrow, its assets and its weaknesses in front of the other energies and within the framework of a sustainable development, are so many subjects which were discussed. The different tackled subjects are: the stakes in the sustainable development; energy perspectives; the reactors of the fourth generation; nuclear power and transparency; sustainable development and I.R.S.N. (N.C.)

  3. Nuclear armament and disarmament; Armement et desarmement nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-05-01

    This document discusses the objectives and the specifications of the non-proliferation treaty, in the framework of the nuclear armament and disarmament. Three chapters are proposed: State of the art; the international agreements and treaties and the United Nation Organization part; debates and forecasts on the proliferation fight, the Pugwash movement and a chronology of the situation. (A.L.B.)

  4. What nuclear industry after Fukushima?; Quel nucleaire apres Fukushima?

    Energy Technology Data Exchange (ETDEWEB)

    Barre, Bertrand [Institut national des sciences et techniques nucleaires, CEA-Saclay, 91191 Gif-sur-Yvette Cedex (France)

    2011-07-01

    Nuclear power experienced a fast growth during the 70's and 80's, but a quasi-stagnation during the 90's. Since the beginning of the 21. century, a so-called renaissance could be witnessed, fuelled by concerns about energy security of supply, volatility of oil and gas prices, fear of an incoming 'peak oil', and, last but not least, the threat of global climate change due to the anthropogenic emissions of greenhouse effect gases. Then, on March 11 2011, a monster earthquake followed by a violent tsunami triggered an accident which all but destroyed four nuclear reactors on the Fukushima-Daiichi site, on the east coast of Honshu, the main Japanese island. There was meltdown in three reactor cores, hydrogen explosions which blew off the upper structures of four reactor buildings, and massive radioactive contamination of a spread of land north-west of the site as well as radioactive releases to the ocean. This accident triggered reactions of various intensities throughout the world, awakening the fears, and questions raised 25 years before by the Chernobyl accident. But the tsunami did not make the fundamentals of the renaissance disappear. After a pause, to fully learn lessons from the accident, the renaissance is likely to start again, all the much since the 'third generation' nuclear plants would have survived unscathed the Fukushima earthquake and tsunami. (author)

  5. Nuclear engineering vocabulary; Vocabulaire de l'ingenierie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The terms, expressions and definitions presented in this booklet come from the works carried out by the French specialized commission of nuclear engineering terminology and neology. This selection of terms cannot be found, in general, in classical dictionaries, or can be found but with a different meaning than the one used in nuclear engineering. All terms and expressions contained in this booklet have been already published in different issues of the Official Journal of the French Republic. This publication makes their use mandatory in replacement of foreign language equivalents inside all government services and public buildings. (J.S.)

  6. Nuclear, uranium, reserves, sustainability, independence; Nucleaire, Uranium, reserves, durabilite, independance

    Energy Technology Data Exchange (ETDEWEB)

    Acket, C

    2007-06-15

    In order to evaluate the energy independence concerning the nuclear energy, the author takes the state of the art about the uranium. He details the fuel needs, the reserves on the base of the today available techniques, the reserves on the base of the future techniques and concludes positively on the energy independence for the nuclear. (A.L.B.)

  7. Nuclear disarmament: the rebound?; Desarmement nucleaire: le rebond?

    Energy Technology Data Exchange (ETDEWEB)

    Durand, D. [Institut de Documentation et de Recherche sur la Paix - I. D. R. P., 93 - Saint-Ouen (France)

    2010-07-01

    The elimination of nuclear weapons is very often considered as a naive and unrealistic utopia, or as an ethical ambition or requirement but with no possible implementation. In this book, the author shades light on some concrete elements of the existing debate between international actors: governments, institutions, but also non-governmental organizations and opinion movements born during the last non-proliferation treaty conference. (J.S.)

  8. Non-nuclear energies; Les energies autres que le nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Nifenecker, H. [Laboratoire de Physique Subatomique et de Cosmologie, IN2P3-CNRS/UJF/INPG, 53 av. des Martyrs, 38026 Grenoble Cedex and Sauvons le Climat (http://www.sauvonsleclimat.org), Grenoble (France)

    2007-07-01

    The different meanings of the word 'energy', as understood by economists, are reviewed and explained. Present rates of consumption of fossil and nuclear fuels are given as well as corresponding reserves and resources. The time left before exhaustion of these reserves is calculated for different energy consumption scenarios. On finds that coal and nuclear only allow to reach the end of this century. Without specific dispositions, the predicted massive use of coal is not compatible with any admissible value of global heating. Thus, we discuss the clean coal techniques, including carbon dioxide capture and storage. One proceeds with the discussion of availability and feasibility of renewable energies, with special attention to electricity production. One distinguishes controllable renewable energies from those which are intermittent. Among the first we find hydroelectricity, biomass, and geothermal and among the second, wind and solar. At world level, hydroelectricity will, most probably, remain the main renewable contributor to electricity production. Photovoltaic is extremely promising for providing villages remote deprived from access to a centralized network. Biomass should be an important source of bio-fuels. Geothermal energy should be an interesting source of low temperature heat. Development of wind energy will be inhibited by the lack of cheap and massive electricity storage; its contribution should not exceed 10% of electricity production. Its present development is totally dependent upon massive public support. A large part of this paper follows chapters of the monograph 'L'energie de demain: technique, environnement, economie', EDP Sciences, 2005. (author)

  9. Climatic change and nuclear energy; Changement climatique et energie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, M

    2000-08-15

    The data presented in the different chapters lead to show that nuclear energy ids not a sustainable energy sources for the following reasons: investments in nuclear energy account financing that lacks to energy efficiency programmes. The nuclear programmes have negative effects such the need of great electric network, the need of highly qualified personnel, the freezing of innovation in the fields of supply and demand, development of small performing units. The countries resort to nuclear energy are among the biggest carbon dioxide emitters, because big size nuclear power plants lead to stimulate electric power consumption instead of inducing its rational use. Nuclear energy produces only electric power then a part of needs concerns heat (or cold) and when it is taken into account nuclear energy loses its advantages to the profit of cogeneration installations. Finally nuclear energy is a dangerous energy source, difficult to control as the accident occurring at Tokai MURA showed it in 1998. The problem of radioactive wastes is not still solved and the nuclear proliferation constitutes one of the most important threat at the international level. (N.C.)

  10. Climatic change and nuclear; Changement climatique et nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, M

    2003-07-01

    One of the main priorities of the WWF is to increase the implementing of solutions relative to the greenhouse effect fight. In this framework the foundation published a study on the nuclear facing the climatic change problem. The following chapters are detailed: the nuclear and the negotiations on the climatic change; the nuclear close; the unrealistic hypothesis of the nuclear forecast; the nuclear facing other energy supplying options; supplying efficiency for heating, electric power, gas and renewable energies; the consumption efficiency facing the nuclear; the economical aspects; the deregulation effect; the political aspects; the nuclear AND the greenhouse effect. (A.L.B.)

  11. Nuclear toxicology. To detect, to clean; Toxicologie nucleaire. Dectecter, depolluer

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, D. [CEA Cadarache (IBEB), Lab. de Bioenergetique Cellulaire, 13 - Saint-Paul-lez-Durance (France); Lecomte-Pradines, C. [Institut de Radioprotection et de Surete Nucleaire (IRSN/DEI), Lab. de Radioecologie et d' Ecotoxicologie, 13 - Saint-Paul-lez-Durance (France); Quemeneur, E. [CEA Valrho (IBEB), Lab. de Radioecologie et d' Ecotoxicologie Nucleaire, 30 - Marcoule (France); Petitot, F. [CEA Centre de Pierrelatte, Institut de Radioprotection et de Surete Nucleaire, (IRSN-DRPH-SRBE), Lab. de Radiotoxicologie Experimentale, 26 (France); Souidi, M.; Bertho, J.M. [CEA Fontenay-aux-Roses, Institut de Radioprotection et de Surete Nucleaire, (IRSN-DRPH-SRBE), Lab. de Radiotoxicologie Experimentale 92 (France); Junot, Ch. [CEA Saclay (iBiTec-S/SPI), Lab. d' Etude du Metabolisme des Medicaments, 91 - Gif-sur-Yvette (France); Malard, V. [CEA Valrho (IBEB-SBTN), Lab. de Biochimie des Systemes Perturbes, 30 - Marcoule (France); Berthomieu, C.; Chapon, V. [CEA Cadarache (IBEB), Lab. des Interactions Proteine Metal, 13 - Saint-Paul-lez-Durance (France); Gilbin, R.; Misson-Pons, J. [CEA Cadarache, Institut de Radioprotection et de Surete Nucleaire (IRSN/DEI), Lab. de Radioecologie et d' Ecotoxicologie, 13 - Saint-Paul-lez-Durance (France); Vavasseur, A. [CEA Cadarache (IBEB), Lab. des Echanges Membranaires et Signalisation, 13 - Saint-Paul-lez-Durance (France); Richaud, P. [CEA Cadarache (IBEB), Lab. de Bioenergetique et Biotechnologie des Basteries et Microalgues, 13 - Saint-Paul-lez-Durance (France); Ansoborlo, E.; Taran, F.; Benech, H.; Fattal, E.; Tsapis, N.; Menetrier, F.; Deverre, J.R.; Burgada, R. [CEA Marcoule (DEN/DRCP/CETAMA), 30 (France)

    2009-01-15

    This file shows two complementary parts: one aiming to a better detection of exposure for man and environment and and other one relative to the treatments to be used when there is a contamination. The development of biological captors is a research axis that could be very useful for nuclear toxicologists that wish to dispose of perceptible measurement tools. In the same idea biological markers could be an important help to determine the toxic quantity in organism in case of internal radioactive contamination. About remedial actions, bacteria are able to reduce, to oxide, to capture pollutants and then it is not insane to use them in efficient and low cost remediation for waters or contaminated lands, especially by trace metals or radioactive compounds. Next to them, plants can offer the same service it is the case for sunflower able to treat water loaded in uranium. This file ends with a review of the different treatments known nowadays as therapies for contamination by radioisotopes used in nuclear industry. (N.C.)

  12. New reactor concepts; Nieuwe rectorconcepten - nouveaux reacteurs nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Meskens, G.; Govaerts, P.; Baugnet, J.-M.; Delbrassine, A

    1998-11-01

    The document gives a summary of new nuclear reactor concepts from a technological point of view. Belgium supports the development of the European Pressurized-Water Reactor, which is an evolutionary concept based on the European experience in Pressurized-Water Reactors. A reorientation of the Belgian choice for this evolutionary concept may be required in case that a decision is taken to burn plutonium, when the need for flexible nuclear power plants arises or when new reactor concepts can demonstrate proved benefits in terms of safety and cost.

  13. The large nuclear works; Le grand chantier du nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Stephan, C. [Institut de Physique Nucleaire, (CNRS) 91 - Orsay (France)

    2010-10-15

    This article comments the present development of nuclear energy in the world. This energy is very attractive because it has no impact on greenhouse effect. The author briefly describes the various types of nuclear reactors, their operation principle, their power, their availability, their reliability, their reinforced safety. He also evokes the technological developments which lead to third generation reactors which are currently operated (the EPR is more particularly described). He comments the waste management issue, the possibility of fuel recycling, evokes the Myrrha reactor project, and the perspective of fourth generation reactors which will have to be both critical and sur-regenerator (or fast breeder): different projects and ideas are presented, notably mini-reactors

  14. Nuclear situation in Japan; La situation du nucleaire au Japon

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This analysis takes stock on the nuclear situation in Japan. It discusses the ambitious equipment program in collaboration with the France, the destabilization of the japanese nuclear industry following the accidents and the energy policy evolutions. It presents the projects of the japanese nuclear industry: the Monju reactor restart, the Pluthermal project, the reprocessing power plant of Rokkasho Mura, the new reactors, the russian weapons dismantling, the ITER site selection and the buy out of Westinghouse by Toshiba. (A.L.B.)

  15. Which nuclear energy for tomorrow?; Quelle energie nucleaire demain?

    Energy Technology Data Exchange (ETDEWEB)

    Huffer, E.; Nifenecker, H

    2001-03-01

    Facing the constant increase of electric power consumption, the authors wonder about the energy sources possibilities. After a synthesis of the fossil fuels and the renewable energies they present the nuclear energy and more specially the new hybrid reactor project (Carlo Rubbia), or ADS (Accelerator Driven System). (A.L.B.)

  16. All about nuclear sciences; Tout savoir sur le nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Le Blanc, A. [CEA Saclay DSM-SAC/USL2TI/STI/SVI, 91 - Gif-sur-Yvette (France)

    2009-07-01

    This French/English flyer, made by the French INIS team of CEA-Saclay, presents the INIS information system, the coverage and content of the database and makes the promotion of the opening of the database to free access through the web link: http://inisdb2.iaea.org/. (J.S.)

  17. Nuclear molecular imaging of paragangliomas; Imagerie moleculaire nucleaire des paragangliomes

    Energy Technology Data Exchange (ETDEWEB)

    Taieb, D.; Tessonnier, L.; Mundler, O. [Service central de biophysique et de medecine nucleaire, CHU de la Timone, 13 - Marseille (France)

    2010-08-15

    Paragangliomas (PGL) are relatively rare neural crest tumors originating in the adrenal medulla (usually called pheochromocytoma), chemoreceptors (i.e., carotid and aortic bodies) or autonomic ganglia. These tumors are highly vascular, usually benign and slow-growing. PGL may occur as sporadic or familial entities, the latter mostly in association with germline mutations of the succinate dehydrogenase (SDH) B, SDHC, SDHD, SDH5, von Hippel-Lindau (VHL), ret proto-oncogene (RET), neurofibromatosis 1 (NF1) (von Recklinghausen's disease), prolyl hydroxylase domain protein 2 (PHD2) genes and TMEM127. Molecular nuclear imaging has a central role in characterization of PGL and include: somatostatin receptor imaging ({sup 111}In, {sup 68}Ga), MIBG scintigraphy ({sup 131}I, {sup 123}I), {sup 18}F-dihydroxy-phenylalanine ({sup 18}F-DOPA) positron emission tomography (PET), and {sup 18}F-deoxyglucose ({sup 18}F-FDG) PET. The choice of the tracer is not yet fully established but the work-up of familial forms often require the combination of multiple approaches. (authors)

  18. Exit this way; Par ici la sortie du nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This paper aims to inform the public on the nuclear power phaseout necessity. The fist part presents the hazards bound the nuclear activities, from the uranium mines to the radioactive wastes disposal and the reasons of a necessary phaseout. The second part recalls the historical aspects of the nuclear power implementation in the french energy policy and the today government attitude to value its choice. The last part presents the advantages of other energies sources and scenario of nuclear power phaseout. (A.L.B.)

  19. All nuclear: a French exception; Tout nucleaire: une exception francaise

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    This little book, written by a nuclear opponent, explains how and why France has become one of the only European countries that has developed nuclear energy as the main energy source for power generation. It denounces the hypocrisy of the official talk, the economical logics, the political manipulation and the lack of information about the real risks linked with nuclear wastes.

  20. The dismantling of nuclear installations; Le demantelement des installations nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Lacoste, A.C.; Duthe, M.; Mignon, H. [Ministere de l`Industrie, des Postes et Telecommunications et du Commerce Exterieur, 75-Paris (France). Direction de la Surete des Installations Nucleaires; Charles, Th. [CEA Centre d`Etudes de Fontenay-aux-Roses, 92 (France). Inst. de Protection et de Surete Nucleaire; Michon, D. [Electricite de France (EDF), 75 - Paris (France); Lambert, F. [Unite de demantelement des installations nucleaires (UDIN), CEA (France); Pradel, Ph. [Compagnie Generale de Matieres Nucleaires (COGEMA), 30 - Bagnols-sur-Ceze (France). Etablissement de Marcoule; Vergne, C. [CODEM Groupement d`interet economique (France); Hillewaere, J.P.; Dupre la Tour, St. [DRIRE Nord-Pas-de-Calais (France); Mandil, C. [Ministere de l`Economie, des Finances et de l`Industrie (France); Weil, L.; Eickelpasch, N.; Finsterwalder, L. [Office Federal de radioprotection, (Germany)

    1997-10-01

    for nuclear installations, the dismantling is an important part of their exploitation. The technology of dismantling is existing and to get a benefit from the radioactive decay, it seems more easy for operating company such E.D.F. to wait for fifty years before dismantling. But in order to get the knowledge of this operation, the Safety Authority wanted to devote this issue of `Controle`to the dismantling method. This issue includes: the legal aspects, the risks assessment, the dismantling policy at E.D.F., the site of Brennilis (first French experience of dismantling), the dismantling techniques, the first dismantling of a fuel reprocessing plant, comparison with classical installations, economic aspect, some German experiences, the cleansing of the american site of Handford. (N.C.)

  1. A comprehensive survey of nuclear reactions; Panorama des reactions nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Cugnon, J. [Liege Univ., IFPA, AGO Dept. (Belgium)

    2007-07-01

    The various mechanisms of nuclear reactions are surveyed and classified in different regimes, based on the notions of coherent mechanisms and hard versus soft processes. The emphasis is put on the concepts at the basis of the understanding of these regimes and on the elements of nuclear structure which are involved in these different regimes, as well as the on the possibility of extracting this information. Due to lack of space and for pedagogical reasons, the discussion is limited to nucleon-induced and light-ion-induced reactions. However, a few remarks are given concerning some specific probes, such as weakly bound projectiles or neutron-rich nuclei. (author)

  2. experience du service de medecine nucleaire sahloul sousse dans ...

    African Journals Online (AJOL)

    ... M. Guezguezb,c, H. Essabbaha,c . a- Faculté de médecine de Monastir, avenue Avicenne 5019 Monastir, Tunisie b- Faculté de médecine de Sousse, rue Mohamed Karoui, 4002 Sousse, Tunisie c- Service de médecine nucléaire, centre hospitalo-universitaire de Sahloul, route de Ceinture, Sahloul 4054 Sousse, Tunisie.

  3. Medical, Industrial and research uses of ionizing radiations: statements and authorizations; Utilisations medicales, industrielles et de recherche des rayonnements ionisants: declarations et autorisations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-12-15

    The nuclear safety authority ensures, in the name of the government, the monitoring of nuclear safety and radiation protection in France to protect the workers, the public and environment from risks linked to the use of ionizing radiations. It contributes to the citizens information. (N.C.)

  4. L’autorisation de pèlerinage à La Mecque (al-Hajj) pour Abd el-Kader : implications politique et métaphysique

    OpenAIRE

    Bouyerdene, Ahmed

    2012-01-01

    En décembre 1847, après plus de quinze années à la tête du jihâd, l’émir Abd el-Kader exige en échange de sa reddition qu’un vaisseau français le dépose dans un port du Levant pour ensuite rejoindre La Mecque. Victime d’un parjure, il est placé en captivité en France (1848-1852), période au cours de laquelle il réitère son vœu de se rendre dans la première ville sainte de l’islam. Après sa libération et son départ pour l’Orient (déc. 1852), il lui faut encore attendre dix ans avant de prendre...

  5. Organizing a complex transport while guaranteeing safety and transparency: the example of vitrified wastes sent back to Germany

    International Nuclear Information System (INIS)

    Krochmaluk, Julie; Lebrun, Marc; Delmestre, Alain; Barbey, Pierre; Bonvalot, Vanessa; Belleville, Didier; Rollinger, Patrice; Alter, Ulrich

    2012-01-01

    This chapter is made of several small articles entitled: - 'Les controles avant le depart du convoi franco-allemand' (Controls before the departure of the French-German convoy); - 'La supervision des transports de matieres radioactives: une approche extensive de la surete des operations' (The supervision of radioactive material transports: an extended approach of operation safety); - 'Le dispositif d'information du public sur le transport des substances radioactives mis en place par l'ASN' (The plan implemented by the ASN for public information on nuclear materials transport); - 'Le recours de l'ASN a l'expertise de l'ACRO sur le convoi de colis de dechets vitrifies vers l'Allemagne' (The appeal of the ASN to the ACRO's expertise on the vitrified parcel convoy to Germany); - 'La participation du collectif STOP-EPR a l'inspection de l'ASN du convoi de colis de dechets vitrifies vers l'Allemagne' (The participation of the STOP-EPR collective to the control by the ASN of the vitrified parcel convoy to Germany); - 'La securite et la surete: des valeurs que le Groupe SNCF partage' (Security and safety: values which are shared by the SNCF Group); - 'Le transport de matieres nucleaires entre la France et l'Allemagne au cours des 40 dernieres annees' (Transport of nuclear materials between France and Germany during the last 40 years). Addressing the case of vitrified wastes transported back to Germany, the articles indicate the controls performed in France before convoy departure, discuss the approach adopted for the safety of radioactive material transport, comment the management of public information by the ASN for such transports, comment the intervention of the ACRO (Association for the control of radioactivity in western France) on the request of the ASN and the participation of a collective group (STOP-EPR) to the inspection of a convoy, outline the commitment of the French Railways (SNCF) in terms of security and safety, and give a qualitative and quantitative

  6. ASN guide project: complete cleaning-up modalities acceptable in nuclear base installations in France - ASN guide project nr 14 - Release of 21/06/2010

    International Nuclear Information System (INIS)

    2010-01-01

    As any nuclear base installation evolves during its exploitation, some premises or buildings may change of use or be destroyed. In the first case, a complete cleaning up might be necessary to get rid of radioactive products. In order to deal with this issue, after a brief recall of the regulatory context and references, and a recall of the general doctrine of waste management in nuclear base installations in France, this guide project presents the principles for a complete cleaning up of structures belonging to an area containing nuclear wastes. It describes the modalities of definition of three different and successive defence lines. It defines the requirements in performing cleaning-up operations, the requirements in terms of quality insurance, and the different administrative procedures (before, during and after cleaning-up works). Some particular cases are addressed

  7. "Občasné" a "dočasné" rezidence Jana Lucemburského v Lucembursku, Francii a Itálii

    Czech Academy of Sciences Publication Activity Database

    Benešovská, Klára

    2008-01-01

    Roč. 11, - (2008), s. 147-167 ISSN 0862-979X. [Dvory a rezidence ve středověku II. Praha, 18.10.2007-19.10.2007] Institutional research plan: CEZ:AV0Z80330511 Keywords : Gothic architecture * 14th century * John of Luxembourg * residences Subject RIV: AL - Art, Architecture, Cultural Heritage

  8. Květena Brna - současný stav poznání

    Czech Academy of Sciences Publication Activity Database

    Lososová, Z.; Šumberová, Kateřina; Tichý, L.; Danihelka, Jiří; Vymazalová, M.

    2015-01-01

    Roč. 63, č. 6 (2015), s. 289-292 ISSN 0044-4812 R&D Projects: GA ČR GB14-36079G Institutional support: RVO:67985939 Keywords : grid mapping * neophytes * city landscape Subject RIV: EH - Ecology, Behaviour

  9. Generativita v současném empirickém výzkumu

    Czech Academy of Sciences Publication Activity Database

    Millová, Katarína; Blatný, Marek

    2016-01-01

    Roč. 60, č. 6 (2016), s. 609-621 ISSN 0009-062X R&D Projects: GA ČR GA15-22474S Institutional support: RVO:68081740 Keywords : generativity * personality * well -being * parenting * family * work Subject RIV: AN - Psychology Impact factor: 0.242, year: 2016

  10. Ribonuclease A mutant His(119)Asn : The role of histidine in catalysis

    NARCIS (Netherlands)

    Panov, Konstantin I.; Kolbanovskaya, Elena Yu.; Okorokov, Andrei L.; Panova, Tatiana B.; Terwisscha Van Scheltinga, Anke; Karpeisky, Marat Ya.; Beintema, Jaap J.

    1996-01-01

    Bovine pancreatic ribonuclease A (RNase A) has been widely used as a convenient model for structural and functional studies, The enzyme catalyzes cleavage of phosphodiester bonds in RNA and related substrates, Three amino acid residues located at the active site of RNase A (His(12), His(119), and

  11. Tazatel, dotazovaný - dočasní "přátelé"

    Czech Academy of Sciences Publication Activity Database

    Nosková, Jana

    -, č. 35 (2004), s. 121-126 ISSN 1211-5770 Institutional research plan: CEZ:AV0Z9058907 Keywords : ethics * fieldwork * relationship between interviewew and interviewee Subject RIV: AC - Archeology, Anthropology, Ethnology

  12. Generativita v současném empirickém výzkumu

    Czech Academy of Sciences Publication Activity Database

    Millová, Katarína; Blatný, Marek

    2016-01-01

    Roč. 60, č. 6 (2016), s. 609-621 ISSN 0009-062X R&D Projects: GA ČR GA15-22474S Institutional support: RVO:68081740 Keywords : generativity * personality * well-being * parenting * family * work Subject RIV: AN - Psychology Impact factor: 0.242, year: 2016

  13. Současný trend protiotřesové prevence v OKR

    Czech Academy of Sciences Publication Activity Database

    Ptáček, Jiří; Koníček, Petr; Golasowski, J.; Waclawik, Petr

    2014-01-01

    Roč. 62, č. 4 (2014), s. 10-14 ISSN 1210-7697 Institutional support: RVO:68145535 Keywords : exploitation of coal * rockburst prevention * Ostrava - Karviná coal field Subject RIV: DH - Mining , incl. Coal Mining

  14. Cloud computing: vývoj a současný stav

    Directory of Open Access Journals (Sweden)

    Václav Sova Martinovský

    2018-06-01

    Full Text Available This article introduces the area of cloud computing with emphasis on businesses and organizations. It includes research of published papers on topic of cloud computing based on metaanalysis and SLR. Summary of relevant advantages both from the user and provider perspective was assembled as well as a list of barriers to even broader adoption of the cloud computing technology. Three databases (EBSCO, ProQuest and Web of Science were used as a source of data for the literature review phase. An analysis of the number of articles dealing with the cloud computing top has been carried out to date. The annual number of publications is compared to the size of the cloud computing market. Frequency analysis at a keyword level was performed in the 25,000-records dataset gathered from the WoS database. This analysis was conducted over the entire monitored period, and only for 2017, to capture the latest trends. There were identified the most frequently used key words in publications about cloud computing: virtualization, security, big data, mobile cloud computing and internet of things. For each of these keywords, a brief summary is given based on the literature search, with an emphasis on the outlook for the future and market position.

  15. Solid state chemistry of new polysulphides in A/Sn/S (A = Na, K, Rb ...

    Indian Academy of Sciences (India)

    Administrator

    compounds possess novel, low and three-dimensional structural frameworks and also unique physical properties. Synthetic and structural solid state chemistry of the polychalcogenides has been an active area of research for the last ten years. In this work, we present the results of our synthetic and structural investigations ...

  16. Současné antropologické divadlo v Polsku

    OpenAIRE

    Dolanová, Michala

    2007-01-01

    The diploma work maps the development of Polish anthropological theatre, the origins of which date back to Polish Romanticism which continues to be one of the strongest theatre trends. It is divided into six chapters. In the first one the author tries to define the concept theatre anthropology, mentions the most important personalities who participated in its rise and worked out its theoretical subsoil, and marginally covers three of the most important participants of the practical root of an...

  17. Conserved water-mediated H-bonding dynamics of catalytic Asn ...

    Indian Academy of Sciences (India)

    Prakash

    Extensive energy minimization and molecular dynamics simulation studies up to 2 ns on all the PDB and solvated structures clearly revealed the involvement of the H-bonding association of the two water molecules in fixing the orientation of the asparagine residue of the catalytic triad. From this study, it is suggested that ...

  18. Nespisovnost v současné zpívané poezii

    OpenAIRE

    Mohylová, Barbora

    2013-01-01

    This thesis explores the phenomenon of hip hop as one of the distinctive forms of contemporary sung poetry. The thesis examines hip hop lyrics especially linguistically, the attention is paid mainly to the characteristics of nonstandard language as the common Czech, the expressivity and numerous vulgarisms connected with it, but also the slang, which has the hip hop subculture either created or has taken over from English. The first part of this thesis is devoted to hip hop subculture and hip...

  19. Současné poznatky o obecné strupovitosti hlíz brambor

    Czech Academy of Sciences Publication Activity Database

    Krištůfek, Václav; Diviš, J.; Marečková, M.; Kopecký, J.

    2015-01-01

    Roč. 63, č. 2 (2015), s. 75-76 ISSN 0139-6013 R&D Projects: GA MZe QJ1210359 Institutional support: RVO:60077344 Keywords : common scab * potatoes Subject RIV: GF - Plant Pathology, Vermin, Weed, Plant Protection

  20. Etiologie časně vzniklé obezity u dětí

    OpenAIRE

    Hainerová, Irena

    2007-01-01

    The aim of the dissertation was to contribute to the understanding of genetic influences that contribute to obesity in childhood. The specific objective was to monitor the cohort of Czech children with early-caused obesity prevalence of mutations of selected genes, which are applied in the pathogenesis of monogenic forms of obesity.

  1. Institut sociální reklamy v současném Rusku.

    OpenAIRE

    Lebedzeva, Krystsina

    2011-01-01

    The bachelor's thesis addresses the problem of social advertising in Russia. The thesis provides an in-depth theoretical analysis of an examined issue, states the history of formation of social advertising in Russia and indicates a period of its instituonalization; moreover it examines the current trends and tendencies and names the most important for the Russian society topics of social advertising. The thesis reveals all the problems that prevent an effective functioning of social advertisi...

  2. Impressions from a visit by the ASN of the Laue Langevin Institute research reactor in Grenoble

    International Nuclear Information System (INIS)

    Nifenecker, H.

    2011-01-01

    After having recalled some specific characteristics of the Laue Langevin Institute research reactor (fuel type, cooling system, power, fuel management, fuel storage pool), the author reports the examination of the emergency procedures and of the reactor maintenance. He describes two exercises which respectively simulated the occurrence of an earthquake and that of a flooding due to a dam breaching

  3. Etika a současná média

    OpenAIRE

    Odstrčilová, Helena

    2008-01-01

    This master's thesis is concerned with ethics in relation to the contemporary media, with a special emphasis on electronic media and their impact on the fragmentarization of both ethics and the objective view of the world.

  4. Gastroturismus - aktuální trend v současném turismu

    OpenAIRE

    Šejdová, Barbora

    2013-01-01

    This bachelor thesis deal with culinary tourism, as a new trend of tourism. Based on the definition of the field uses the scientific method of bibliographic search and statistical data. It focuses on the concept of inclusion in the typology of tourism. It issues the impact of tourism on the economy and the role of multiplier effects within the general theme. The practical part deals with culinary tourism and it's conception in Austria. First general issues of Austrian tourism are analyzed, wi...

  5. Současný vývoj v proteomice

    Czech Academy of Sciences Publication Activity Database

    Collinsová, Michaela; Jiráček, Jiří

    2004-01-01

    Roč. 98, č. 12 (2004), s. 1112-1118 ISSN 0009-2770 R&D Projects: GA AV ČR IAA4055302 Institutional research plan: CEZ:AV0Z4055905 Keywords : proteomics * proteome * 2-D electrophoresis Subject RIV: CE - Biochemistry Impact factor: 0.348, year: 2004

  6. Role ženy v současné společnosti

    OpenAIRE

    Slunéčková, Tereza

    2008-01-01

    This thesis is focused on the woman's role in present-day society. Theoretical part is about woman's role from legal point of view, historical context and current perspective within education, work and family. Empirical part is represented by the research which goal is to find out the attitude to woman's role in family and in work area and discovery of functional gender sterotypes in society mainly froma men and women's point of view and also according to the education and age groups.

  7. O apozici v současném německém jazyce

    OpenAIRE

    Kučerová, Lucie

    2013-01-01

    This bachelor thesis is concerned with the state of apposition in contemporary German language. The first part gives a definition of the apposition and its characteristics in the existing grammar books and linguistic studies as well as other related topics (classification of the apposition, the use of case, the declination of titles, professions and relatives). It also deals with some chosen aspects (the terminological inconsistency in the specialized literature, the vague state of apposition...

  8. Heterologous gln/asn-rich proteins impede the propagation of yeast prions by altering chaperone availability.

    Directory of Open Access Journals (Sweden)

    Zi Yang

    Full Text Available Prions are self-propagating conformations of proteins that can cause heritable phenotypic traits. Most yeast prions contain glutamine (Q/asparagine (N-rich domains that facilitate the accumulation of the protein into amyloid-like aggregates. Efficient transmission of these infectious aggregates to daughter cells requires that chaperones, including Hsp104 and Sis1, continually sever the aggregates into smaller "seeds." We previously identified 11 proteins with Q/N-rich domains that, when overproduced, facilitate the de novo aggregation of the Sup35 protein into the [PSI(+] prion state. Here, we show that overexpression of many of the same 11 Q/N-rich proteins can also destabilize pre-existing [PSI(+] or [URE3] prions. We explore in detail the events leading to the loss (curing of [PSI(+] by the overexpression of one of these proteins, the Q/N-rich domain of Pin4, which causes Sup35 aggregates to increase in size and decrease in transmissibility to daughter cells. We show that the Pin4 Q/N-rich domain sequesters Hsp104 and Sis1 chaperones away from the diffuse cytoplasmic pool. Thus, a mechanism by which heterologous Q/N-rich proteins impair prion propagation appears to be the loss of cytoplasmic Hsp104 and Sis1 available to sever [PSI(+].

  9. Assessment of pressurized nuclear equipment compliance - ASN guide no. 8, version of 04/09/2012

    International Nuclear Information System (INIS)

    2012-01-01

    This document describes the modalities according to which the compliance assessment of pressurized nuclear equipment must be performed by inspecting organisations according to a decree of December 1999 and an order of December 2005. After an indication of reference documents and some technical definitions, this guide describes the equipment classification and the principles of intervention. These principles concern the assessment request and the various assessment tasks to be performed by the inspecting organisation

  10. Cestovní ruch v EU: současné trendy

    OpenAIRE

    Jurištová, Lucia

    2012-01-01

    The aim of this master thesis is to analyze the current trends in tourism in the European union. Then also determine which factors influence its further development, as well as predict the future trends in tourism in the EU. The thesis is also trying to answer scientific questions regarding the impact of the global economic and financial crisis on the development of tourism in the regions of the European Union, the specific factors affecting the tourism trends in the European Union and the ac...

  11. Krajané a současné migrační procesy

    Czech Academy of Sciences Publication Activity Database

    Uherek, Zdeněk

    2013-01-01

    Roč. 23, č. 4 (2013), s. 235-240 ISSN 0862-8351 Institutional support: RVO:68378076 Keywords : migration * expatriates * compatriots * Europe * Czech Republic Subject RIV: AC - Archeology, Anthropology, Ethnology

  12. Současná věda o člověku

    Czech Academy of Sciences Publication Activity Database

    Černý, Viktor; Brůžek, J.

    2016-01-01

    Roč. 64, č. 5 (2016), s. 202 ISSN 0044-4812 Institutional support: RVO:67985912 Keywords : anthropology Subject RIV: AC - Archeology, Anthropology , Ethnology http://ziva.avcr.cz/files/ziva/pdf/soucasna-veda-o-cloveku.pdf

  13. Současné podnikatelské prostředí Německa

    OpenAIRE

    Dědinová, Michaela

    2011-01-01

    The Federal Republic of Germany is one of the biggest economies in Europe as well as in the world and it is undoubtedly the most important business partner of the Czech Republic. The aim of this Bachelor thesis is to analyse the business environment of Germany using the PEST analysis and to define the specifics of this environment. Thereby I will provide the Czech businesses intending to expand on the German market with the latest, verified and complete information. The Bachelor thesis is enr...

  14. Současné podnikatelské prostředí Chile

    OpenAIRE

    Matoušek, Ondřej

    2015-01-01

    This diploma thesis aims to analyse the current state of the Chilean business environment and highlight the benefits, opportunities as well as possible threats of the Chilean market for Czech exporters. The work is divided into four chapters. The initial definition of the business environment and the determination of used methods is followed by the actual analysis of the business environment. PESTLE analysis is used to explore the political, economic, socio-cultural, technological, environmen...

  15. Status of radiation protection in interventional radiology. Assessment of inspections in 2009 by the ASN

    International Nuclear Information System (INIS)

    2011-01-01

    This report first describes the organization of inspections performed in health institutions, indicates the inspected establishments, the types of fixed installations in interventional radiology, the use of imagery in the operating theatre, and discusses the regulatory arrangements applicable to interventional radiology (in the Public Health Code, in the Labour Code). Then, the report discusses the results of inspections regarding radiation protection in interventional radiology: application of public health code arrangements (justification, patient training in radiation protection, radiological procedures and protocols, patient dosimetry monitoring), application of Labour Code arrangements (designation of the person with expertise in radiation protection, risk assessment and delimitation of monitored and controlled areas, workstation analysis, workers' training in radiation protection, individual protection equipment, workers' dosimetric monitoring, workers' medical monitoring, radiation protection technical controls), significant events, radiation protection in operating theatre. Propositions are stated regarding the differences noticed within or between the health establishments, the methodological and organisational difficulties faced by persons with expertise in radiation protection (PCR), the need of an interdisciplinary team

  16. Současné české neologismy z oblasti sportu

    OpenAIRE

    Filiačová, Sylva

    2014-01-01

    This bachelor thesis discusses the new appearance of substantive, adjective, verbal, and adverbial phrases in the sports area of the Czech language. The thesis is materially based on the database NEOMAT (Institute of the Czech Language of the Academy of Sciences of the Czech Republic), the databases of the Czech National Corpus, and the Newton Media archive. The first part of the thesis covers the definition of the concept of neologism. The following chapter discusses the ways of genesis of n...

  17. A future for nuclear sites beyond their service life. Nuclear site value development; Un avenir pour les sites nucleaires en fin de cycle. Valorisation des sites nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    As the nuclear industry moves into a new development phase, many facilities built in the fifties and sixties are reaching the end of their service life. Dismantling them and rehabilitating the sites on which they stand is a major industrial challenge which will give rise to a number of new projects. AREVA has more than 20 years' experience in these highly technical fields. As more and more sites reach the end of their service life, AREVA considers nuclear site value development as a fully-fledged industrial activity. The group's competencies in this field have been grouped together to form a dedicated entity: the Nuclear Site Value Development Business Unit, created in 2008. Several billion euros are invested in site value development projects which are far-reaching and complex, and often last for several decades. Long before work actually begins, lengthy studies and preparations are required to schedule operations, select the techniques to be used and optimize costs and deadlines. The Nuclear Site Value Development BU is currently working on four major projects involving its own facilities and those of the CEA: - La Hague: dismantling of the first generation of used fuel recycling facilities. Between 1966 and 1998, almost 5,000 tons of used fuel from graphite-moderated gas-cooled reactors, 4,500 tons of light water reactor fuel, as well as fuel from fast reactors and research reactors, were treated at UP2 400, the very first industrial recycling plant on the La Hague site. - Marcoule: first-time dismantling of a recycling plant. 1,000 rooms to be cleaned up, 30,000 tons of waste to be treated, 30 years of work. - Cadarache: first-time dismantling of a Mox fuel fabrication plant. The Cadarache plant was commissioned in 1962 to fabricate fuel for fast reactors; this was followed by MOX fuel for light water reactors, an activity which continued until the plant was shut down in 2003. - Annecy and Veurey: giving a new lease of life to former industrial sites in built-up areas. AREVA is currently working on a site value development program on two industrial sites in Annecy and Veurey, near Grenoble. Dating back to 1955 and 1957, the sites were created for the manufacture and precision machining of uranium metal. The number of clean-up and dismantling projects is set to rise steadily in the years ahead and site value development will unquestionably become a new nuclear activity in its own right. AREVA is developing the corresponding competencies and expertise: new professions are springing up (value development project manager, scenario and feedback manager, operational dismantling methods manager, flushing operator, etc.) and a dedicated theoretical and practical training program is being put together. Once a nuclear site has been shut down, the long-term dismantling and value development operations make a considerable contribution to the local economy. Site rehabilitation is an environmental necessity and improves nuclear's image in the eyes of the public. As new nuclear projects get off the ground, developing the value of disused sites will free up space for future projects and make a valuable contribution to the nuclear revival.

  18. Nuclear safety and radiation protection report of the Flamanville nuclear facilities - 2010; Rapport sur la surete nucleaire et la radioprotection des installations nucleaires de Flamanville - 2010

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-06-15

    This safety report was established under the article 21 of the French law no. 2006-686 of June 13, 2006 relative to nuclear safety and information transparency. It presents, first, the facilities of the Flamanville nuclear power plant (Manche (FR)): 2 PWR reactors in operation (INB 108 and 109), and 1 PWR under construction (Flamanville 3, INB 167). Then, the nuclear safety and radiation protection measures taken regarding the facilities are reviewed: nuclear safety definition, radiation protection of intervening parties, safety and radiation protection improvement paths, crisis management, external and internal controls, technical situation of facilities, administrative procedures in progress. The incidents and accidents which occurred in 2010, are reported as well as the radioactive and non-radioactive (chemical, thermal) effluents discharge in the environment. Finally, The radioactive materials and wastes generated by the facilities are presented and sorted by type of waste, quantities and type of conditioning. Other environmental impacts (noise, water consumption and waste management at Flamanville 3 construction site) are presented with their mitigation measures. Actions in favour of transparency and public information are presented as well. The document concludes with a glossary and a list of recommendations from the Committees for health, safety and working conditions. (J.S.)

  19. Nuclear safety and radiation protection report of the Chooz nuclear facilities - 2010; Rapport sur la surete nucleaire et la radioprotection des installations nucleaires de Chooz - 2010

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-06-15

    This safety report was established under the article 21 of the French law no. 2006-686 of June 13, 2006 relative to nuclear safety and information transparency. It presents, first, the facilities of the Chooz nuclear power plant (Ardennes (FR)): 2 PWR reactors in operation (Chooz B, INB 139 and 144) and one partially dismantled PWR reactor (Chooz A, INB 163). Then, the nuclear safety and radiation protection measures taken regarding the facilities are reviewed: nuclear safety definition, radiation protection of intervening parties, safety and radiation protection improvement paths, crisis management, external and internal controls, technical situation of facilities, administrative procedures in progress. The incidents and accidents which occurred in 2010, are reported as well as the radioactive and non-radioactive (chemical, thermal) effluents discharge in the environment. Finally, The radioactive materials and wastes generated by the facilities are presented and sorted by type of waste, quantities and type of conditioning. Other environmental impacts (noise, microbial proliferation in cooling towers) are presented with their mitigation measures. Actions in favour of transparency and public information are presented as well. The document concludes with a glossary and a list of recommendations from the Committees for health, safety and working conditions. (J.S.)

  20. Nuclear safety and radiation protection report of the Chinon nuclear facilities - 2010; Rapport sur la surete nucleaire et la radioprotection des installations nucleaires de Chinon - 2010

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-06-15

    This safety report was established under the article 21 of the French law no. 2006-686 of June 13, 2006 relative to nuclear safety and information transparency. It presents, first, the facilities of the Chinon nuclear power plant (Indre-et-Loire, 37 (FR)): 4 PWR reactors in operation (Chinon B, INB 107 and 132), 3 partially dismantled graphite-gas reactors (Chinon A, INB 133, 153 and 161), a workshop for irradiated materials (AMI, INB 94), and an inter-regional fuel storage facility (MIR, INB 99). Then, the nuclear safety and radiation protection measures taken regarding the facilities are reviewed: nuclear safety definition, radiation protection of intervening parties, safety and radiation protection improvement paths, crisis management, external and internal controls, technical situation of facilities, administrative procedures in progress. The incidents and accidents which occurred in 2010, are reported as well as the radioactive and non-radioactive (chemical, thermal) effluents discharge in the environment. Finally, The radioactive materials and wastes generated by the facilities are presented and sorted by type of waste, quantities and type of conditioning. Other environmental impacts (noise, microbial proliferation in cooling towers) are presented with their mitigation measures. Actions in favour of transparency and public information are presented as well. The document concludes with a glossary and a list of recommendations from the Committees for health, safety and working conditions. (J.S.)

  1. La Reggenza et les autorisations : l’application des lois sur les fidéicommis et la mainmorte dans la Toscane des Lorraines (1737-1765

    Directory of Open Access Journals (Sweden)

    Lara Marchi

    2010-05-01

    Full Text Available Date de soutenance : le 19 décembre 2009 à l’ÉHESS 54 Boulevard. Raspail, Paris.Composition du juryMonsieur Gérard Delille, Directeur d’études à l’éHESS (Directeur de thèse, Monsieur Eric Brian, Directeur d’études à l’ÉHESS et Directeur scientifique adjoint de l’INSHS du CNRS, Monsieur Marcello Verga, Professeur à Université de Sciences Politiques« Cesare Alfieri » de Florence, Monsieur Paolo Malanima, Directeur de l’Istituto di Studi sulle Società del Mediterraneo du CNR de Naples et Profes...

  2. Should we be scared of nuclear energy?; Faut-il avoir peur du nucleaire?

    Energy Technology Data Exchange (ETDEWEB)

    Allegre, C.

    2011-07-01

    The recent accident of the Fukushima daiichi power plant has re-launched the nuclear debate in France. On the one hand, the nuclear power allows the French consumers to benefit by the cheapest electricity in Europe. On the other hand the undeniable accidents spread fears and doubts about the safety of nuclear facilities. Therefore, should we trust the scientists and technical specialists when they claim that the potential danger is weak? The author takes stock of the question without taboos or prejudices and supplies to us the scientific, technical, economical and political elements allowing anyone to make his own opinion based on reason and not on emotion or fear. (J.S.)

  3. Elecnuc. Nuclear power plants in the world; Elecnuc. Les centrales nucleaires dans le monde

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    This small booklet summarizes in tables all the numerical data relative to the nuclear power plants worldwide. These data come from the French CEA/DSE/SEE Elecnuc database. The following aspects are reviewed: 1999 highlights; main characteristics of the reactor types in operation, under construction or on order; map of the French nuclear power plants; worldwide status of nuclear power plants at the end of 1999; nuclear power plants in operation, under construction and on order; capacity of nuclear power plants in operation; net and gross capacity of nuclear power plants on the grid and in commercial operation; grid connection forecasts; world electric power market; electronuclear owners and share holders in EU, capacity and load factor; first power generation of nuclear origin per country, achieved or expected; performance indicator of PWR units in France; worldwide trend of the power generation indicator; 1999 gross load factor by operator; nuclear power plants in operation, under construction, on order, planned, cancelled, shutdown, and exported; planning of steam generators replacement; MOX fuel program for plutonium recycling. (J.S.)

  4. Nuclear energy: French government policy; Politique nucleaire et diversification energetique: orientations gouvernementales

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-02

    This report presents the French government policy concerning nuclear energy and alternative sources of energy for the next 10 years. This report overviews the situation of Super-Phenix fast reactor and presents the implications of the 30/12/1999 decree (Bataille's law) about the management of radioactive wastes.

  5. Joliot-Curie School of Nuclear Physics, 1997; Ecole Joliot-Curie de Physique Nucleaire, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Abgrall, Y. [L`Institut National de Physique Nucleaire et de Physique des Particules du CNRS (India2P3), 75 - Paris (France); Collaboration: La Direction des Sciences de la Matiere du CEA (FR); Le Fonds National de la Recherche Scientifique de Belgique (BE)

    1998-12-31

    This document contains the lectures of the Joliot-Curie International School of Nuclear Physics held at Maubuisson, France on 8-13 September 1997. The following lectures of nuclear interest were given: The N-body problem (relativistic and non-relativistic approaches); The shell model (towards a unified of the nuclear structure); Pairing correlations in extreme conditions; Collective excitations in nuclei; Exotic nuclei (production, properties and specificities); Exotic nuclei (halos); Super and hyper deformation (from discrete to continuum, from EUROGAM to EUROBALL); and The spectroscopy of fission fragments. Important new facts are reported and discussed theoretically, concerning the nuclei in high excitation and high states and of the nuclei far off stability. Important technical achievements are reported among which the production of radioactive beams, sophisticated multi-detectors as well as significant advances in the nuclear theoretical methods. The double goal of training of young researchers and of permanent formation and information of the older ones seems to have been reached

  6. Institut de Physique Nucleaire d'Orsay. Highlights and achievements 2008-2013

    International Nuclear Information System (INIS)

    2013-01-01

    Activities of the Institute through the 2008-2013 period, have been considerable and a detailed description of all of them would have resulted in a relatively large document. The choice was then made to only describe a selection of highlights from the activities of the different groups during the last 5 years. This concerns the five main scientific topics of the institute that are: 1- Nuclear Structure and Dynamics: The highlights described in this section concern the activities of two different research groups 'NESTER' and 'NIM'; 2 - Hadrons and Hadronic Matter: This section concerns the three teams involved in the CLASS collaboration at JLab, the HADES collaboration at GSI and the ALICE collaboration at LHC. All three are part of the group 'PHEN'; 3- Physics and Chemistry of Nuclear Energy: This section covers, on one hand, activities related to Nuclear Data and Simulations of novel option for nuclear energy production within the group 'PACS' and, on the other hand, all the activities that are performed within the 'RC (Radio-chemistry group)'; 4- Astrophysics: This section concerns nuclear astrophysics research activity at the group 'NESTER', the astro-chemistry activity at the 'NIM' group and the astro-particle activity within the 'AUGER' collaboration in the group 'PHEN'; 5 - Theory: This activity concerns mainly the 'Theory' group. Beside these five scientific topics a multidisciplinary activity based mainly on the use of accelerated nanoparticles with the TANDEM accelerator at ALTO is also described. Two additional sections are devoted in the document to summarize the activities related to: 1 -Accelerator physics and technology; 2 - Detector technology, instrumentation and data acquisition and processing. A separate paragraph gives a status report and highlights from the main facilities in the Institute such as ALTO, SUPRATECH and CACAO. The activities on 'Dosimetry' in one hand and on 'Safety and Radiation Protection' on the other hand as well as an overview of the activities within the 'Communication' group are summarized in separate paragraphs. A short paragraph is also given in order to remind the vital activities for the running and functioning of the institute that are covered by the Administration, Logistics and Infrastructure Division (DALI). A special attention was given these last years for continuous training of the personnel. This is motivated by the importance of keeping and passing over the expertise as well as of helping identifying promotion perspectives for all categories of employees (chapter 14). A self-evaluation is proposed in chapter 15. This self-evaluation is largely based on the conclusions of the evaluation of our activities by the Scientific and Technical Advisory committee of the Institute. For each of the activity reports various information is given such as the dedicated human resources and their evolution during the last 5 years, scientific production in terms of publications, participation to conferences etc

  7. Information report nuclear energy in Europe; Rapport d'information energie nucleaire en Europe

    Energy Technology Data Exchange (ETDEWEB)

    Montesquiou, A. de

    2002-07-01

    This report takes stock on the nuclear energy situation in Europe. The European Union with more than 40% of the nuclear power capacity in the world, is already confronted with the nuclear energy place and stakes in the future energy policy. The report si presented in two main parts. The first part, ''the assets and the weaknesses of the nuclear energy'', deals with the economical aspects which historically based the choice of the nuclear energy and the induced impacts on the environment. The competitiveness of the nuclear energy but also the wastes management problem are discussed. The second part, ''the diplomatic and juridical framework of the nuclear energy development'', details and presents the limits of the EURATOM treaty. (A.L.B.)

  8. Fatigue damage of nuclear facilities; Endommagement par fatigue des installations nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The conference on the fatigue damage of nuclear facilities, organized by the SFEN (french society of nuclear energy), took place at Paris the 23. of november 2000. Eleven papers were presented, showing the state of the art and the research programs in the domain of the sizing rules, safety, installations damage, examination and maintenance. (A.L.B.)

  9. International nuclear panorama. Developments october 2001 - april 2002; Panorama nucleaire international. Developpements octobre 2001 - avril 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    This panorama presents the today situation of the nuclear parks and the future tendencies, by a political and economic analysis of the governments policy, for the following continents: north America, west Europe, Asia, South America, Africa, Russia and east europe. (A.L.B.)

  10. Nucleaire et Energies Nr 63 - June 2014. 18 months before the Paris Climate Conference

    International Nuclear Information System (INIS)

    Lenail, Bernard; Ducroux, Guy; Lamorlette, Guy; Seyve, Claude; Simonnet, Jacques; Justin, Francois; Darricau, Aime; Blanc, Jacques; Salanave, Jean-Luc; Raisonnier, Daniele; Deleigne, Francoise

    2014-06-01

    After a first article which evokes the perspective and challenges of the Paris Climate Conference, two articles address energy issues: a discussion of the evolution of the energy sector (challenge of energy transition, evolutions of the energy mix in different countries, shale gases in the USA, Europe and France, electricity prices in France, situation and projects of French energy companies) and an overview of news in the renewable energy sector (in Morocco, Germany and the UK, the second bidding for offshore wind projects in France). Three articles deal with nuclear energy: agreements and projects in Niger, news about various fuel production sites in different countries, overview of the situation of reactors (EPR, China) and decisions on projects and investments in different countries, overview of activities and events related to the back-end of the fuel cycle (notably in different Areva sites) and to decommissioning in different countries. Four articles address societal issues related to nuclear safety and environment (relationships between French nuclear operators and Safety Authorities, the situation of populations around Fukushima, Greenpeace in Fessenheim, the issue of fuel sheath wear, use of rare earth materials in wind turbines), a positive perception of the presence of Areva (after Cogema) in Niger, a scenario for Fessenheim, and the deep disposal Cigeo project

  11. What expects rheumatologist from bone scan; Qu'attend le rhumatologue de la medecine nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Sutter, B. [Institut Calot, 62 - Berck sur Mer (France); Meys, E. [Centre Hospitalier Duchenne, 62 - Boulogne sur Mer (France)

    2003-11-01

    Conventional bone scintigraphy continues to be one of the most common diagnostic imaging requested by rheumatologist, despite development of new investigation modalities. Three (or two) phase bone scintigraphy, Single Photon Emission Computer Tomography have increased its value and provided new clinical roles. This review emphasizes through some practical clinical examples how to increase diagnostic value of the method, especially in the field of inflammatory diseases at early stages (rheumatoid arthritis and spondyl-arthropathy). Scintigraphy appears as a diagnostic tool, with requirements between clinical examination and radiographic examination-X Ray, computed tomography, ultrasonography, MRI. (author)

  12. 1984. Annual progress report of the Institut de Physique Nucleaire at Orsay

    International Nuclear Information System (INIS)

    1985-01-01

    The first part of this report presents the work of the year 1984 of research in the Division of experimental physics of the Institute of Nuclear Physics in Orsay, the activities are conducted in six axes: nuclear structure, high excitation energy nuclear states, heavy ion collision phenomena, intermediate energy nuclear physics, radiochemistry and perinuclear research. The second part presents the studies of the theoretical physics division of the Institute for Nuclear Physics in Orsay in 1984. The different research axes are the following: nuclear physics, intermediate energy nuclear physics, elementary particles. The third part presents a compilation of the work done by the technical groups of the laboratory. The different axes are: operation and development of accelerators, design studies on new superconducting cyclotron project equipment and instrumental projects, technical developments used for specific research [fr

  13. Microscopic description of nuclear structure; La structure nucleaire decrite par les theories microscopiques

    Energy Technology Data Exchange (ETDEWEB)

    Girod, M.; Berger, J.F.; Peru, S.; Dancer, H. [CEA Bruyeres-le-Chatel, 91 (France)

    2002-07-01

    After briefly recalling the formalism of the mean field approach with an effective nucleon-nucleon interaction, the theoretical framework of the nuclear structure studies performed at CEA-DAM, applications of this theory to various nuclear systems: shape and spin isomeric states, neutron and proton rich nuclei, superheavy and hyper-heavy nuclei, and to the fission process are presented. (authors)

  14. Nuclear Internet: Back to a future (at nucleaire.edf.fr)

    International Nuclear Information System (INIS)

    Aubouin, Pascal; Borel, Remi

    2001-01-01

    The world is changing. Environment and Health are key issues, especially in western countries. People start to worry about the impact of the products they use or eat and about their legacy to their children, on a worldwide scale : 'We do not inherit the earth from our parents; we borrow it from our children' is one of the current new motto for the c itizens of Earth . In such a context, nuclear energy is less accepted than before. The recent debate over the ozone layer, global warming and climate change, GMOs, mad-cow disease and most recently uranium-based ammunitions, cannot but reinforce the deep mistrust felt by large components of the society. Opponents to nuclear energy have found a new audience, and some political decisions take this evolution into account. This mistrust is reinforced by the absence of a direct link between EDF and the general public. However: a new attitude is emerging, which might be an opportunity for us. Citizens demand the right to know, the right to shape their own point of view, using first-hand information. Internet is an obvious answer to this need for more personal, human contact. This presentation discusses how do you establish a link with people browsing the net, so they can shape their own opinion about nuclear energy? A climate of trust is key, based on the following ingredients: Transparency; Responsibility and trustworthiness; Openness and Empathy; Innovation; Interactivity. An overview on 8 months activity is displayed. The EDF web site has improved since its launch and is still improving today. It is not considered a finished product

  15. The radioactive wastes management; Le dossier: les dechets nucleaires et leur gestion

    Energy Technology Data Exchange (ETDEWEB)

    Rigny, P. [Actualite Chimique, 75 - Paris (France); Bonin, B. [CEA Saclay, Dir. de l' Energie Nucleaire, 91 - Gif sur Yvette (France); Gras, J.M. [Electricite de France (EDF-RD), Recherche et Developpement, 78 - Chatou (France)

    2010-11-15

    The different types of radioactive waste are presented in this paper in the frame of the official categories which take into account their dangerousness and the lifetimes of their radioactivity. It is indicated how the less dangerous of them are handled in France. The ways of protecting the environment from the more dangerous ones (high activity and long lifetimes) are object of studies. Scientific questions, in the field of chemistry and physical chemistry, related to the implementation of deep underground repository facilities with full respect of nuclear safety are presented. (authors)

  16. The Chernobyl murder. The nuclear Goulag; Le crime de Tchernobyl. Le goulag nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Tchertkoff, W

    2006-07-01

    The authors of this book are the Chernobyl victims of the 26 April 1986 nuclear accident: millions of poor farmers, contaminated young mothers and children which eat every days radionuclides; ''Liquidators'', sacrificed to stop the fire of the power plants; invalids and also doctors and scientists which refuse the nuclear lobby. This book presents the two Byelorussian scientists which have risk their career and their health to help the contaminated populations. This book takes stock on the today nuclear policy and becomes alarm in seeing the development of the nuclear program in many countries. (A.L.B.)

  17. French people and nuclear wastes; Les francais et les dechets nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    D' Iribarne, Ph. [Centre National de la Recherche Scientifique (CNRS), 75 - Paris (France)

    2005-07-01

    On March 21, 2005, the French minister of industry gave to the author of this document, the mission to shade a sociological light on the radioactive wastes perception by French people. The objective of this study was to supply an additional information before the laying down in 2006 of the decisions about the management of high-level and long-lived radioactive wastes. This inquiry, carried out between April 2004 and March 2005, stresses on the knowledge and doubts of the questioned people, on the vision they have of radioactive wastes and of their hazards, and on their opinion about the actors in concern (experts, nuclear companies, government, anti-nuclear groups, public). The last two parts of the report consider the different ways of waste management under study today, and the differences between the opinion of people living close to the Bure site and the opinion of people living in other regions. (J.S.)

  18. Prospective economical study of the nuclear power file; Etude economique prospective de la filiere electrique nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Charpin, J.M. [Commissariat General du Plan, 75 - Paris (France); Dessus, B. [Ecodev-CNRS, 92 - Meudon (France); Pellat, R. [CEA, 75 - Paris (France)

    2000-07-01

    On May 7, 1999 an economical study of the overall nuclear file, and in particular, of the back-end part of the fuel cycle and including the reprocessing, was requested by the French Prime Minister. This study includes the cost comparisons with the other means of power production and takes into consideration the environmental costs. The study is shared into five chapters dealing with: 1 - the legacy of the past: todays park of nuclear plants, economical and material status; 2 - the international evolution: the dynamics of nuclear policies worldwide (existing parks and R and D programs), the rise of environmental problems worldwide (CO{sub 2} and the climate convention, nuclear risks, attempts of including environment in the power costs), the choices made for the management of spent fuels in the main countries; 3 - the technological prospects for the power production and use: technologies for the mastery of power demand (residential, industrial and tertiary sectors, power transportation), technologies of power production (production from nuclear, fossil and renewable energies); 4 - prospective scenarios for France: two demand scenarios at the year 2050 vista (energy, electric power), power supply (supply structure with respect to scenarios, nuclear parks, power capacities), environmental aspects (CO{sub 2} emissions, plutonium and minor actinides production); 5 - the economical status of the different scenarios: data preparation, fossil fuel price scenarios, investment and operation costs of the different power production means (nuclear, fossil and renewable energies, natural gas and power distribution networks), comparison between fluxes and cumulated economic costs linked with the different scenarios (investments, exploitation, fuels, R and D, status for 2000 to 2050), time structure of expenditures with respect to the different scenarios (chronology, statuses, kWh costs, sensitivity with respect to the rate of discount, valorization of existing parks in 2050), cost overruns with respect to pollutant emissions. (J.S.)

  19. Critical aspects of the nuclear multifragmentation; Etude du caractere critique de la multifragmentation nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Marie, J

    2004-06-01

    From statistical mechanics, this thesis looks for a phase transition signal in nuclei. We try to describe critical aspects of the nuclear multifragmentation. Thermodynamical observables as fragment mass/charge distributions are used in those finite systems. The percolation theory is first applied to strictly statistical events from the lattice gas model framework at the thermodynamical critical point. The scaling functions obtained are quantitatively comparable for every sample. Critical exponents are almost the same as the liquid/gas universality class ones. The second part is devoted to Fisher's model framework taking into account for the chemical potential and the surface energy coefficient. The extracted critical temperature is compatible with the percolation one. Experimental samples are then studied from peripheral (Au+Au) and central (Xe+Sn) heavy ion collisions. Entrance channel memory effects are evidenced in peripheral events. The presence of collective flow make the central ones far away from the conditions required by Fisher's model. Nevertheless, the critical energy found is independent of the data characteristics. This curious stability has to be studied. (authors)

  20. Particles identification using nuclear emulsion in OPERA; Identification des particules par les emulsions nucleaires dans OPERA

    Energy Technology Data Exchange (ETDEWEB)

    Manai, K

    2007-10-15

    The Opera experiment will try to confirm the {nu}{sub {mu}} {yields} {nu}{sub {tau}} oscillations by the appearance of the {nu}{sub {tau}} in a pure {nu}{sub {mu}} beam. Indeed, a neutrino beam almost pure is produced at CERN (CNGS Beam) and sent to the Opera detector. The detector is composed of two muons spectrometers and a target formed by walls of bricks. Each brick is an alternation of lead plates and emulsions. This modular structure allows to reconstruct the kink topology of the {tau} lepton decay with a high spatial resolution. The great challenge of the Opera experiment is to detect the {nu}{sub {tau}} interactions with the less uncertainty. To reduce this uncertainty it is essential to identify with the greatest efficiency any background event not including a tau particle. My work permits to reduce background. My principal contribution concerns the selection development, the reconstruction and the muons identification at low energy. This work is based on the setting of variables related to the deposit energy and the multiple scattering. Previously, only deposit energy was used in the analyses of pion/muon separation. This study allows doubling the muon identification efficiency at low energy. This leads to increase the background events rejection in Opera and to decrease the contamination by 30%. I also studied the nuclear emulsions capacity to identify charged particles through the analysis of a test beam carried out by the Nagoya group. This test contains protons and pions with different energies. My work proves that the European scan system gives comparable results with those obtained by the Japanese scan system. (author)

  1. Energy policy: the nuclear in debate; Politique energetique: le nucleaire en debat

    Energy Technology Data Exchange (ETDEWEB)

    Deleuze, O. [Secretariat d' Etat Belge a l' Energie et au Developpement Durable (Belgium); Roussely, F. [Electricite de France, EDF, 75 - Paris (France); Dessus, B. [Centre National de la Recherche Scientifique, CNRS, 75 - Paris (France); Lauvergeon, A. [Cogema, 78 - Velizy Villacoublay (France); Colombani, P. [CEA, 75 - Paris (France); Revol, H.; Jedliczka, M.; Baupin, D.; Arditi, M.; Fell, H.J

    2000-07-01

    Debates about energy policy for the France: Members of Parliament, the presidents of Electricite de France and Cogema, spokespersons for the ecologists political group, scientists, general administrator of the Cea, member of the Deutsche Bundestag set out their different points of view about the future of nuclear energy. Energy conservation and efficiency, renewable energy sources, carbon dioxide emissions and Kyoto protocol, energy supplies safety, economic points of view are as many points tackled during these debates. If everyone agrees to think that it is necessary to diversify the energy sources, no agreement comes to light about the place of nuclear energy in this diversification. (N.C.)

  2. Institut National des Sciences et Techniques Nucleaires. From academic to vocational: specificity and vision

    International Nuclear Information System (INIS)

    Turpin, Laurent

    2008-01-01

    - What is INSTN?: Teaching and training service of CEA; Capability of awarding degrees; Stand-alone: only specialty degrees; Partnership with universities and Engineer schools: master degrees; Professional training operator for CEA and for SMEs. - Corner stones for the next future (5-10 years): increasing the capability in nuclear training (Nuclear skills for nuclear engineers (reactor physics,...), factor 3-4, Nuclear skills for non-nuclear engineers (civil works, project management,...), All stakeholders have to do more (Academics on basic knowledge (have to prepare to a wide range of positions), Specialty institutes on specialized knowledge (before the job and on the job), Internal programs on proprietary programs), optimizing the resources (No false hope: more training means higher costs but does not mean nuclear companies will lay golden eggs; Availability of teaching resource and capability of internship tutoring could be bottlenecks; Trained/graduate production must match actual human resources needs). - A strategy for INSTN: Academic partnerships, to implement nuclear modules within training programs; With companies, a stakeholder-shareholder joint venture model for postgraduate training; Open to European and offshore cooperation

  3. Links between nuclear medicine and radiopharmacy; Structuration des liens entre medecine nucleaire et radiopharmacie

    Energy Technology Data Exchange (ETDEWEB)

    Pelegrin, M. [Inserm, U896, CRLC Val-d' Aurelle-Paul-Lamarque, institut de recherche en cancerologie de Montpellier (IRCM), universite Montpellier 1, 34 - Montpellier (France); Francois-Joubert, A. [Service de medecine nucleaire, centre hospitalier de Chambery, 73 - Chambery (France); Chassel, M.L. [Radiopharmacie, service de pharmacie, centre hospitalier de Chambery, 73 - Chambrry (France); Desruet, M.D. [Service de radiopharmacie et service pharmaceutique, clinique universitaire de medecine nucleaire, CHU de Grenoble, 38 - Grenoble (France); Bolot, C. [Service de radiopharmacie, service pharmaceutique, centre de medecine nucleaire, groupement hospitalier Est, 69 - Bron (France); Lao, S. [Service de radiopharmacie, medecine nucleaire, hopital de l' Archet, 06 - Nice (France)

    2010-11-15

    Radiopharmaceuticals are nowadays under the responsibility of the radio-pharmacist because of their medicinal product status. Radiopharmacy belongs to the hospital pharmacy department, nevertheless, interactions with nuclear medicine department are important: rooms are included or located near nuclear medicine departments in order to respect radiation protection rules, more over staff, a part of the material and some activities are shared between the two departments. Consequently, it seems essential to formalize links between the radiopharmacy and the nuclear medicine department, setting the goals to avoid conflicts and to ensure patients' security. Modalities chosen for this formalization will depend on the establishment's organization. (authors)

  4. The diverse applications of the nuclear power; Les diverses applications du nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    The three great categories of application in industry and environment of ionizing radiations are the use of ionizing radiation to transport energy in matter it is industrial irradiation, the use of radioactive sources of low activity to analyze and measure, it is the nucleonic instrumentation, the use of radioactive tracers to follow and study the matter transfer. Are explained the treatments to improve the plastic materials and the ionisation of food. (N.C.)

  5. The nuclear seems to be accepted unanimously; Le nucleaire semble deja faire l'unanimite

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2003-02-01

    The 34. forum of Iena has allowed to different participants to express their point of view on the future energy choices before the beginning of the national debate. Through the choice of different European countries or the interventions of the big French energy groups, the nuclear energy seems already to be a must. (N.C.)

  6. Which future for the nuclear counter-proliferation?; Quel avenir pour la contre-proliferation nucleaire?

    Energy Technology Data Exchange (ETDEWEB)

    Duval, M

    2004-10-01

    After a recall of the permanent data about proliferation and of the safeguards implemented by the international community, the author demonstrates that proliferation has moved towards Asia where a real 'black market' has been created. Then he analyzes the consequences of this change on the future of nuclear deterrent. Finally, he expresses his nostalgia in front of this drift and worries about the future uselessness of the means devoted to this 'pacifying' strategy. (J.S.)

  7. Evaluation by the Department de Surete Nucleaire of unsolved PWR safety problems

    International Nuclear Information System (INIS)

    Dupuis, M.C.; Cayol, A.; Fourest, B.

    1980-04-01

    The deterministic or probabilistic methods of safety analysis and the analysis of accidents used at the design and construction stage have enabled certain safety problems connected with the PWR programme in France to be identified. Some of these problems have already been stressed by the NRC whereas others are specific to the safety approach practised in France. These problems have led to the adoption of special measurements on the reactors already in operation and should be accounted for in the design of future installations. Analysis of running experience and of incidents should be used to check the validity of the steps taken at the design stage and to identify the weak points of the facilities, especially in their piloting and at the man-machine interface [fr

  8. Effets du milieu sur la propagation des neutrinos dans la matiere nucleaire

    CERN Document Server

    Margueron, J

    2001-01-01

    We study the elementary interactions between neutrinos and dense matter in a proroneutron star. Equations of state obtained with different nuclear effective interactions (skyrme, Gogny, relativistic Lagrangians) are first discussed.Then we characterize their stability in spin and isospin. We derive magnetic susceptibilities for all isospin asymmetry values as a function of Landau parameters G^{tau tau'}_0 (where tau, tau' = proton or neutron)We calculate nthe pure neutron matter response functions with and withoutcharge exchange, describing nuclear correlations in both approaches : non-relativistic and relativistic. At the end we calculate neutrino mean free paths for neutral current and charged current reactions.Comparisons between relativistic and non-relativistic approaches allow us to identify relativistic effects in nuclear matter at densities as low as twice the saturation density.RPA correlations make the medium more transparent to neutrinos compared to free Fermi gas.

  9. Elecnuc. Nuclear power plants in the world; Elecnuc. Les centrales nucleaires dans le monde

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    This small booklet summarizes in tables all data relative to the nuclear power plants worldwide. These data come from the IAEA's PRIS and AREVA-CEA's GAIA databases. The following aspects are reviewed: 2007 highlights; Main characteristics of reactor types; Map of the French nuclear power plants on 2007/01/01; Worldwide status of nuclear power plants (12/31/2007); Units distributed by countries; Nuclear power plants connected to the Grid- by reactor type groups; Nuclear power plants under construction on 2007; Evolution of nuclear power plants capacities connected to the grid; First electric generations supplied by a nuclear unit in each country; Electrical generation from nuclear power plants by country at the end 2007; Performance indicator of French PWR units; Evolution of the generation indicators worldwide by type; Nuclear operator ranking according to their installed capacity; Units connected to the grid by countries at 12/31/2007; Status of licence renewal applications in USA; Nuclear power plants under construction at 12/31/2007; Shutdown reactors; Exported nuclear capacity in net MWe; Exported and national nuclear capacity connected to the grid; Exported nuclear power plants under construction; Exported and national nuclear capacity under construction; Nuclear power plants ordered at 12/31/2007; Long term shutdown units at 12/31/2007; COL (combined licences) applications in the USA; Recycling of Plutonium in reactors and experiences; Mox licence plants projects; Appendix - historical development; Meaning of the used acronyms; Glossary.

  10. Nuclear energy: obstacles and promises; L'energie nucleaire: obstacles et promesses

    Energy Technology Data Exchange (ETDEWEB)

    Bacher, P

    2003-07-01

    Nuclear energy has distinctive merits (sustainable resources, low costs, no greenhouse gases) but its development must overcome serious hurdles (fear of accidents, radio-phobia, waste management). The large unit size of present-day reactors is compatible only with large electrical grids, and involves a high capital cost. Taking into account these different factors, the paper outlines how nuclear energy may contribute to the reduction of greenhouse gases, and which are the most promising developments. (author)

  11. Report transparency and nuclear safety 2007 - CISBIO; Rapport transparence et securite nucleaire 2007 - CISBIO

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of CISBIO, nuclear base installation, for the year 2007. CISBIO realizes at Saclay most of the radiopharmaceuticals and drugs distributed in France for the nuclear medicine. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. (A.L.B.)

  12. Fuel and nuclear fuel cycle; Le combustible et le cycle du combustible nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Prunier, C

    1998-07-01

    The nuclear fuel is studied in detail, the best choice and why in relation with the type of reactor, the properties of the fuel cans, the choice of fuel materials. An important part is granted to the fuel assembly of PWR type reactor and the performances of nuclear fuels are tackled. The different subjects for research and development are discussed and this article ends with the particular situation of mixed oxide fuels ( materials, behavior, efficiency). (N.C.)

  13. Nuclear energy for the 21. century; Energie nucleaire pour le 21. siecle

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-03-15

    This document gathers 5 introductory papers to this conference about nuclear energy for the 21. century: the French energy policy during the last 30 years (situation of France with respect to the energy supply and demand, main trends of the French energy policy, future of the French nuclear policy); presentation of IAEA (technology transfer, nuclear safety, non-proliferation policy, structure and financial resources, council of governors, general conference, secretariat); nuclear power and sustainable development; promoting safety at nuclear facilities (promoting safety, basics of safety, safety at the design stage, risk management, regulatory control and efficiency of the regulation organization, role of IAEA); nuclear energy today (contribution to sustainable development, safety, best solution for the management of radioactive wastes, future of nuclear energy). (J.S.)

  14. Nuclear facilities: repair and replacement technologies; Installations nucleaires: technologies de reparation et de remplacement

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    The oldest operating reactors are more than 35 years old and are now facing major maintenance operations. The first replacement of a pressurizer took place in autumn 2005 at the St-Lucie plant (Usa) while steam generators have been currently replaced since 1983. Nuclear industry has to adapt to this new market by proposing innovative technological solutions in the reactor maintenance field. This document gathers the 9 papers presented at the conference. The main improvements concern repair works on internal components of PWR-type reactors, the replacement of major components of the primary coolant circuit and surface treatments to limit the propagation of damages. The first paper shows that adequate design and feedback experience are good assets to manage the ageing of a nuclear unit. Another paper shows that a new repair method of a relief valve can avoid its replacement. (A.C.)

  15. Is there any future for nuclear weapons?; Les armes nucleaires ont-elles un avenir?

    Energy Technology Data Exchange (ETDEWEB)

    Heisbourg, F.

    2011-07-01

    Nuclear weapons occupy a paradoxal place both in the collective imagination and in the historical reality: on the one hand everybody dreads the apocalypse horror, and on the other hand, dissuasion appears as an unchanging and quite comfortable situation. However, the world has become multipolar in this domain as well. The geopolitical map is reconstructing. Doctrinal revisions, initiatives against nuclear weapons proliferation, and nuclear disarmament measures are now on the agenda. The best foreign and French experts examine for the first time the consequences of these evolutions. They analyse in particular the split up risks and the potential consequences of a nuclear conflict in regions where atomic arms have become a key-component of the strategic landscape: Middle-Est, Far-East, Southern Asia. The choices France and its allies will have to face are examined as well. (J.S.)

  16. Fire protection of PWR-type nuclear power plants; Protection incendie des centrales nucleaires REP

    Energy Technology Data Exchange (ETDEWEB)

    Kaercher, M. [Electricite de France (EDF), 75 - Paris (France)

    2004-07-01

    This article presents the fire protection principles applied by Electricite de France (EdF) to PWR-type nuclear power plants, and stresses on the recent evolutions of the design and exploitation approach of fire protection which have contributed to the improvement of nuclear facilities safety: 1 - general presentation; 2 - objectives of the fire protection: integrity of safety systems, personnel and people protection, equipments protection and keeping up of availability; 3 - design requirements: fire prevention, fire confinement, fire mastery, checking approach, formalization of the design approach, experience feedback of the design approach; 4 - example of application, the Chooz B power plant, head of the N4 step series: common dispositions to the different buildings, protection of the reactor building, protection of electrical facilities, protection of the turbine building, protection of transformers, protection of the emergency power sets, protection of hydrogen hazard buildings; 5 - in-service protection: intervention of the operator, fire fighting organization, reactor operation during fire accident; 6 - conclusion. (J.S.)

  17. The nuclear power cycle; Le cycle de l'energie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    Fifty years after the first nuclear reactor come on-line, nuclear power is fourth among the world's primary energy sources, after oil, coal and gas. In 2002, there were 441 reactors in operation worldwide. The United States led the world with 104 reactors and an installed capacity of 100,000 MWe, or more than one fourth of global capacity. Electricity from nuclear energy represents 78% of the production in France, 57% in Belgium, 46% in Sweden, 40% in Switzerland, 39% in South Korea, 34% in Japan, 30% in Germany, 30% in Finland, 26% in Spain, 22% in Great Britain, 20% in the United States and 16% in Russia. Worldwide, 32 reactors are under construction, including 21 in Asia. This information document presents the Areva activities in the nuclear power cycle: the nuclear fuel, the nuclear reactors, the spent fuel reprocessing and recycling and nuclear cleanup and dismantling. (A.L.B.)

  18. Thematic sheets on the nuclear energy; Fiches thematiques sur l'energie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Tevissen, E.; Galle, Ch.; L' Hostis, V.; Millard, A.; Moulin, Ch.; Mauchien, P.; Vitart, X.; Rivalier, P.; Diop, Ch.; Boullis, B.; Feron, D.; Santarini, G.; Lieven, Th.; Laffont, G.; Cachon, L.; Moulin, C

    2004-07-01

    This document presents eleven description sheets of researches realized in the CEA laboratories. The following topics are concerned: the diffusion of tritiated water, iodine 125 and chlorine 36 in the Meuse/Haute-Marne rocks of the underground laboratory of Bure; effect of the granulates nature on the thermal and hydro mechanics behavior of concrete at high temperature (60-450 C); first validation of a damage model for reinforced concrete affected by the corrosion of its reinforcements; analysis of pollutants traces; centrifuge extractors of the high activity laboratory; the advanced partitioning; the disadvantages of the Monte-Carlo method in the radiation protection domain; the Purex process; materials damage by enzymes; the acoustic emission applied for the materials corrosion; the helium circuits technology for the gas cooled reactors; high level speciation. (A.L.B.)

  19. Introduction to nuclear energy; Introduction a l'energie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    After some descriptions about atoms, fission and fusion, explanations are given about the functioning of a nuclear power plant. The safety with the different plans of emergency and factors that lead to a better nuclear safety are exposed, then comes a part for the environmental protection; the fuel cycle is tackled. Some historical aspects of nuclear energy finish this file. (N.C.)

  20. Transparency associated with the nuclear fuel cycle; Transparence associee au cycle du combustible nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    This document presents the different fuel cycle stages with which the CEA is associated, the annual flow of materials and wastes produced at these different stages, and the destiny of these produced materials and wastes. These information are given for the different CEA R and D activities: experimentation hot laboratories (activities, fuel cycle stages, list of laboratories, tables giving annual flows for each of them), research reactors (types of reactors, fuel usage modes, annual flows of nuclear materials for each reactor), spent fuel management (different types of used materials), spent fuels and radioactive wastes with a foreign origin (quantities, processes)

  1. Institut National des Sciences et Techniques Nucleaires. From academic to vocational: specificity and vision

    Energy Technology Data Exchange (ETDEWEB)

    Turpin, Laurent [Institut National des Sciences et Techniques Nucleaires - INSTN, CEA-Saclay (France)

    2008-07-01

    - What is INSTN?: Teaching and training service of CEA; Capability of awarding degrees; Stand-alone: only specialty degrees; Partnership with universities and Engineer schools: master degrees; Professional training operator for CEA and for SMEs. - Corner stones for the next future (5-10 years): increasing the capability in nuclear training (Nuclear skills for nuclear engineers (reactor physics,...), factor 3-4, Nuclear skills for non-nuclear engineers (civil works, project management,...), All stakeholders have to do more (Academics on basic knowledge (have to prepare to a wide range of positions), Specialty institutes on specialized knowledge (before the job and on the job), Internal programs on proprietary programs), optimizing the resources (No false hope: more training means higher costs but does not mean nuclear companies will lay golden eggs; Availability of teaching resource and capability of internship tutoring could be bottlenecks; Trained/graduate production must match actual human resources needs). - A strategy for INSTN: Academic partnerships, to implement nuclear modules within training programs; With companies, a stakeholder-shareholder joint venture model for postgraduate training; Open to European and offshore cooperation.

  2. Elecnuc. Nuclear power plants in the world. 1997; Elecnuc. Les centrales nucleaires dans le monde. 1997

    Energy Technology Data Exchange (ETDEWEB)

    Maubacq, F.; Tailland, C

    1997-04-01

    This small booklet provides information about all type of nuclear power plants worldwide. It is based on the data taken from the CEA/DSE/SEE Elecnuc database. The content comprises: the 1996 highlights, the main characteristics of the different type of reactors in operation or under construction, the map of the French nuclear power plant sites, the worldwide status of nuclear power plants at the end of 1996, the nuclear power plants in operation, under construction or on order (by groups of reactor-types), the power capacity evolution of power plants in operation, the net and gross capacity of the power plants on the grid, the commercial operation and grid connection forecasts, the first achieved or expected power generation supplied by a nuclear reactor for each country and the power generation from nuclear reactors, the performance indicator of the PWR units in France, the trends of the power generation indicator worldwide, the nuclear power plants in operation, under construction, on order, planned, cancelled, decommissioned and exported worldwide, the schedule of steam generator replacements, and the MOX fuel plutonium recycling programme. (J.S.)

  3. Elecnuc. Nuclear power plants in the world; Elecnuc. Les centrales nucleaires dans le monde

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-01

    This small booklet summarizes in tables all the numerical data relative to the nuclear power plants worldwide. These data come from the French CEA/DSE/SEE Elecnuc database. The following aspects are reviewed: 1997 highlights; main characteristics of the reactor types in operation, under construction or on order; map of the French nuclear power plants; worldwide status of nuclear power plants at the end of 1997; nuclear power plants in operation, under construction and on order; capacity of nuclear power plants in operation; net and gross capacity of nuclear power plants on the grid and in commercial operation; forecasts; first power generation of nuclear origin per country, achieved or expected; performance indicator of PWR units in France; worldwide trend of the power generation indicator; nuclear power plants in operation, under construction, on order, planned, cancelled, shutdown, and exported; planning of steam generators replacement; MOX fuel program for plutonium recycling. (J.S.)

  4. Laser spectroscopy used in nuclear physics; La spectroscopie laser appliquee a la physique nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Le Blanc, F

    2001-04-05

    The study of nuclear shapes is a basic topic since it constitutes an excellent ground for testing and validating nuclear models. Measurements of the electron quadrupolar moment, of the nuclear charge radius and of the magnetic dipolar moment shed light on the nuclear deformation. Laser spectroscopy is a specific tool for such measurements, it is based on the interaction of the nucleus with the surrounding electron cloud (hyperfine structure), it is then an external approach of the shape of the nucleus whereas the classical nuclear spectroscopy ({alpha}, {beta} or {gamma}) gives information on the deformation from the inside of the nucleus. The author describes 2 techniques of laser spectroscopy: the colinear spectroscopy directly applied to a beam issued from an isotope separator and the resonant ionization spectroscopy linked with atom desorption that allows the study of particular nuclei. In order to illustrate both methods some effective measurements are presented: - the colinear spectroscopy has allowed the achievement of the complete description of the isomeric state (T = 31 years) of hafnium-178; - The experiment Complis has revealed an unexpected even-odd zigzag effect on very neutron-deficient platinum isotopes; and - the comparison of 2 isotopes of gold and platinum with their isomers has shown that the inversion of 2 levels of neutron, that was found out by nuclear spectroscopy, is in fact a consequence of a change in the nuclear shape. (A.C.)

  5. What can be done with nuclear wastes?; Que faire des dechets nucleaires?

    Energy Technology Data Exchange (ETDEWEB)

    Simon, A.; Piechowski, J.; Monchicourt, M.O

    2001-07-01

    In this book, a technical adviser of the French atomic energy commission (CEA) answers the questions of the author about nuclear wastes: how are they produced? Where are they stored? Are they dangerous? How do we protect against their harmful effects? (J.S.)

  6. Back end of the nuclear fuel cycle; Aval du cycle du combustible nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Dognon, J.P.; Rabbe, C.; Beudaert, Ph.; Lamare, V.; Wipff, G.; Moisy, Ph.; Charrin, N.; Blanc, P.; Den Auwer, Ch.; Revel, R.; Charbonnel, M.C.; Presson, M.T.; Cau Dit Coumes, C.; Chopin-Dumas, J.; Devisme, F.; Rat, B.; Hill, C.; Guillaneux, D.; Madic, C.; Carrera, A.; Dozol, J.F.; Rouquette, H.; Allain, F.; Virelizier, H.; Moulin, Ch.; Lemort, F.; Orlhac, X.; Fillet, C.; Carpena, J.; Advocat, T.; Leturcq, G.; Lacombe, J.; Bonnetier, A.; Ribet, I.; Poitou, S.; Richaud, D.; Fiquet, O.; Gramondi, P.; Massit, H.; Meyer, D.; Conocar, O.; Pettier, J.L.; Raphael, T.; Bouniol, P.; Sercombe, J.; Badouix, P.; Adenot, F.; Le Bescop, P.; Mazoin, C.; Motellier, S.; Charles, Y.; Richet, C.; Ayache, R.; Pitsch, H.; Ly, J.; Beaucaire, C.; Devol-Brown, I.; Libert, M.F.; Besnainou, B

    1999-07-01

    In this chapter of the DCC 1999 scientific report, the following theoretical studies are detailed: electronic structure of lanthanides or actinides complexes, forecasting of the stoichiometry of europium nitrate complexes, actinides aqueous solutions analytical and thermodynamical chemistry, actinides complexes structural determination. It also provides experimental studies: actinides and lanthanides separation, radioactive wastes processing and conditioning, plasma torch vitrification process, simulation of the wastes packages characterization, wastes storage with concrete behaviour and biodegradation. (A.L.B.)

  7. Phasing out nuclear, a credible scenario; Sortir du nucleaire, un scenario credible

    Energy Technology Data Exchange (ETDEWEB)

    Chatelain, C.; Mulot, R.; Chauveau, L.; Hait, J.F.

    2011-08-15

    Based on data from different companies, institutions and associations involved in nuclear energy (either in its production or in its critic), this article comments the possible energy savings (50 to 64%) that may be reached in the different sectors, and more particularly in the building sector and in electrical equipment. It discusses the potential production from solar, wind and biogas energy. It notices that phasing out nuclear is possible by 2030-2050, but would entail an increase of electricity prices. The German approach is presented. An article comments the anger of Fukushima Japanese farmers and evokes the slow building up of a solidarity network between France and Japan. A last article comments the authorization given to a further exploitation of the Fessenheim nuclear power plant (ten more years)

  8. Prospective analysis. Nuclear deterrence in 2030; Essai de prospective. La dissuasion nucleaire en 2030

    Energy Technology Data Exchange (ETDEWEB)

    Tertrais, B

    2006-12-15

    This study is a prospective analysis of the long-term future of nuclear weapons, and particularly the future of French nuclear deterrence after 2015. The selected time period is 2025-2030. The principal objective is to reflect on what the nuclear world might look like during the first part of the 21 st century, beyond the modernization decisions already planned or envisaged, and to draw conclusions for the future of the French deterrent. (author)

  9. The underground nuclear wastes storage; Le stockage des dechets nucleaires en site profond

    Energy Technology Data Exchange (ETDEWEB)

    Nifenecker, H. [Institut des Sciences Nucleaires, CNRS/IN2P3, 38 - Grenoble (France); Ouzounian, G. [Agence Nationale pour la Gestion des Dechets Radioactifs ANDRA, 92 - Chatenay Malabry (France)

    2002-07-01

    In the radioactive wastes management, the underground storage seems to be the long dated solution and the reference strategy. Then this storage has to be studied in term of accidental diffusion of radionuclides in the geologic site and in the food chain transfer. This document presents analytical models of diffusion which may help physicists to evaluate underground storage sites and the impacts on the environment and the human health. (A.L.B.)

  10. Elecnuc. Nuclear power plants in the world; Elecnuc. Les centrales nucleaires dans le monde

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This 2003 version of Elecnuc contents information, data and charts on the nuclear power plants in the world and general information on the national perspectives concerning the electric power industry. The following topics are presented: 2002 highlights; characteristics of main reactor types and on order; map of the French nuclear power plants; the worldwide status of nuclear power plants on 2002/12/3; units distributed by countries; nuclear power plants connected to the Grid by reactor type groups; nuclear power plants under construction; capacity of the nuclear power plants on the grid; first electric generations supplied by a nuclear unit; electrical generation from nuclear plants by country at the end 2002; performance indicator of french PWR units; trends of the generation indicator worldwide from 1960 to 2002; 2002 cumulative Load Factor by owners; nuclear power plants connected to the grid by countries; status of license renewal applications in Usa; nuclear power plants under construction; Shutdown nuclear power plants; exported nuclear power plants by type; exported nuclear power plants by countries; nuclear power plants under construction or order; steam generator replacements; recycling of Plutonium in LWR; projects of MOX fuel use in reactors; electricity needs of Germany, Belgium, Spain, Finland, United Kingdom; electricity indicators of the five countries. (A.L.B.)

  11. Nuclear bad year in perspective in 2007; Nucleaire mauvaise annee en perspective en 2007?

    Energy Technology Data Exchange (ETDEWEB)

    Melquiot, P

    2007-07-01

    The author presents a mixed evaluation of the nuclear after the announcement of the shutdown of 7 reactors in the world. The report factor 4 precises that the nuclear energy represents only 2% of the final energy in the world and shows the poor part of the nuclear in the fight against the greenhouse effect. (A.L.B.)

  12. Report transparency and nuclear safety 2007 CEA Saclay; Rapport transparence et securite nucleaire 2007 CEA Saclay

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Saclay for the year 2007. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially two public consultation on release authorizations and the Neurospin installations, the dismantling of the 49 nuclear installation, the shutdown of the learning reactor ULYSSE are detailed. (A.L.B.)

  13. Perspectives for nuclear energy; Perspectives pour l'energie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Baugnet, J.-M.; Abderrahim, H.A.; Dekeyser, J.; Meskens, G

    1998-09-01

    In Belgium, approximately 60 percent of the produced electricity is generated by nuclear power. At present, nuclear power production tends to stagnate in Europe and North America but is still growing in Asia. The document gives an overview of the present status and the future energy demand with emphasis on electric power. Different evaluation criteria including factors hindering and factors promoting the expansion of nuclear power as well as requirements of new nuclear power plants are discussed. The extension of the lifetime of existing facilities as well as fuel supply are taken into consideration. A comparative assesment of nuclear power with other energy sources is made. The report concludes with estimating the contribution and the role of nuclear power in future energy demand as well as with an overview of future reactors and research and development programmes.

  14. The international law of nuclear weapons. Le droit international des armes nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Sur, S. (Universite Pantheon-Assas, 75 - Paris (France). Centre de Recherches Internationales)

    1998-01-01

    The first chapter concerns the questions of non proliferation and non dissemination. Then, the problems bound to nuclear testing are examined in the second chapter. The process of destruction and restriction of weapons are treated in the third chapter. Then, the fourth chapter analyzes the conditions and the perspectives of a negotiation on the cessation of fissile matter production for military uses and more broadly, an obligation to negotiate a nuclear disarmament. (N.C.)

  15. The international law of nuclear weapons; Le droit international des armes nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Sur, S. [Universite Pantheon-Assas, 75 - Paris (France). Centre de Recherches Internationales

    1998-12-31

    The first chapter concerns the questions of non proliferation and non dissemination. Then, the problems bound to nuclear testing are examined in the second chapter. The process of destruction and restriction of weapons are treated in the third chapter. Then, the fourth chapter analyzes the conditions and the perspectives of a negotiation on the cessation of fissile matter production for military uses and more broadly, an obligation to negotiate a nuclear disarmament. (N.C.)

  16. The juridical issues of nuclear activities; Le droit des activites nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Guillaume, M.; Kerever, A. [State adviser, (France); Pasquier, J.L. [Office de Protection contre les Rayonnements Ionisants, 78 - le Vesinet (France); Brillanceau, F. [French Ministry of Labour, (France); Besson, J.P. [CIREA, (France); Chaumette, L.; Niel, J.C.; Reculeau, Y. [Institut de Protection et de Surete Nucleaire (IPSN), (France); Treflez, M.; Pezennec, D. [CEA Agence Nationale pour la Gestion des Dechets Radioactifs (ANDRA), 75 - Paris (France); Cochaud, J.F.; Phan Van, L. [Electricite de France, 75 - Paris (France). Direction de l`Equipement; Biad, A. [Rouen Univ., 76 - Mont-Saint-Aignan (France). Faculte de droit, de sciences economiques et de gestion; Darricau, A. [Compagnie Generale des Matieres Nucleaires (COGEMA), (France); Cormis, F. de [Electricite de France (EdF). Mission Protection et Controle des Matieres Nucleaires (France); Galmot, Y. [Commission Interministerielle des Installations Nucleaires de Base (CIINB), (France); Saint-Raymond, P. [Ministere de l`Industrie, des Postes et Telecommunications et du Commerce Exterieur, 75-Paris (France). Direction de la Surete des Installations Nucleaires; Guenon, C.; Laurens Bernard, O. [Ministere de l`Interieur. Dir. de la Defense et de la Securite Civiles (France); Blanchard, P. [Electricite de France (EdF). Service juridique national (France); Robert, J.H. [Univ. Pantheon-Assas, 75 - Paris (France)

    1997-11-01

    This issue is dedicated to the juridical aspects of civil nuclear activities. It comprises 3 parts and 16 papers. Radiation protection law is dealt with in part 1: prevention of risks due to ionizing radiations in occupational environment; sources and men; the regulation of radioactive materials transport; the regulation of the rejection of gaseous and liquid radioactive effluents. Part 2 tackles the question of checking the pacific uses of nuclear energy, that is the juridical consequences of the non-proliferation and physical protection policies are reviewed: international efforts that aim to limit the military uses of nuclear energy; the juridical and practical aspects of non-proliferation rules and international controls; the national control of radioactive materials. The juridical framing of nuclear activities, nuclear civil liability and infraction of the law are gathered in part 3: the CIINB and its contribution to the safety of nuclear installations; the mining law; the control of nuclear installations safety; the influence of the realization of the nuclear program on the evolution of the French law; the intervention of the administrative judge in nuclear affairs; the protection of population against nuclear risk - statement of existing provisions and new trends; the special regime of the civil nuclear responsibility - at the time of change; the penal infractions of the nuclear law. (J.S.)

  17. Nuclear energy: exit or revival? International aspects; Energie nucleaire: sortie ou relance? Aspects internationaux

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-11-01

    This colloquium took place less than 1 year after the decision of the US of revival of their nuclear program. Thus the international context has changed, even if nuclear contestation remains as strong as in the past. Among governments, some positions preach the banishment of nuclear energy while others consider the nuclear option as the only solution to meet the growing up energy demand and the future environmental and economical stakes. This report makes a synthesis of the different talks given by the participants during the 3 round tables of the colloquium on the future of nuclear energy: the ecological stake, the democratic stake, and the energy policy stake. Four talks of French government representatives open and conclude the debates of the different round tables. (J.S.)

  18. Electromagnetic nuclear life time - theoretical context; Temps de vie electromagnetique nucleaire - contexte theorique

    Energy Technology Data Exchange (ETDEWEB)

    Niez, J.J

    2000-07-01

    One describes here the theoretical tools which are needed for evaluating the nuclear lifetime of a nucleus dipped into electromagnetic surroundings which are composed of electrons and photons. The case where this environment is a material or a cavity will be treated in a following report. (Author)

  19. Simulations. 3D nuclear reactions; Simulations. Reactions nucleaires en 3D

    Energy Technology Data Exchange (ETDEWEB)

    Deleurence, Guillaume

    2012-05-15

    At CEA Saclay, the research programme for the forth generation of nuclear reactors, named 'Astrid' (Advanced Sodium Technological Reactor for Industrial Demonstration) of the Direction of nuclear energy (DEN), uses 2D or 3D movies and a 16 m{sup 2} image wall for the display of simulation results. This digest paper focusses on the technological means used for the simulations: the Curie supercomputer designed by Bull and the images display device. (J.S.)

  20. Nucleaire et Energies Nr 64 - December 2014. A review of the year

    International Nuclear Information System (INIS)

    Lenail, Bernard; Ducroux, Guy; Salanave, Jean-Luc; Miquel, Pierre; Seyve, Claude; Simonnet, Jacques; Justin, Francois; Darricau, Aime; Raisonnier, Daniele; Deleigne, Francoise

    2014-12-01

    After an introduction which proposes a large overview of what went on in different countries in the field of energy, and more particularly nuclear energy, during 2014, three articles address energy issues: an overview of the evolution of the energy sector (oil price sharp decrease, issue of subsidies to energy in Europe, perspectives of energy transition with objectives related to energy production and consumption), a discussion about the role and use of biomass from the fire age to the era of carbon sequestration, and a presentation of the Chevilly-Larue site of geothermal energy. Three article concern nuclear activities: recent events in the mining and fuel fabrication sector, overview of the situation of reactors, whether planned or under construction in different countries, overview of activities and events related to the back-end of the fuel cycle and to decommissioning in different countries. Two articles address societal issues related to nuclear: safety and environment (a European directive, inspections and safety exercises in various French nuclear power plants, the situation in Fukushima, severe accidents in France, the issue of low doses), and a comment on the decision to stop the Osiris reactor

  1. The nuclear energy in the United Kingdom; L'energie nucleaire au Royaume-Uni

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-02-15

    With challenges like the climatic change, the hydrocarbons prices increase and the energy supply security, the nuclear park is becoming a decisive and an urgent question in the United Kingdom. The author proposes an historical aspect of the nuclear energy in UK, the actors of the today nuclear industry and the technologies used in 2006, the radioactive wastes management, the programs of the future and the british opinion on the nuclear. (A.L.B.)

  2. Nuclear law and new legal concepts; Droit nucleaire et concepts juridiques nouveaux

    Energy Technology Data Exchange (ETDEWEB)

    Atias, Ch.; Warusfel, B. [Paris-5 Univ., 75 (France); Byk, Ch. [Association Internationale droit, ethique et science, 75 - Paris (France)

    2003-02-01

    The articles on this topic have been written from three of the papers of the Conference organized on January 14, in Paris by the 'Law and Insurance' Section of the French Nuclear Energy Society together with the French Section of the International Nuclear Law Association. The first two articles deal with transparency, its justifications and limits. The third article analyses the rights of the future generations and our duties towards them. (authors)

  3. The technological prospective of non nuclear channels; La prospective technologique des filieres non nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Claverie, M.; Clement, D.; Girard, C

    2000-07-15

    This prospective study concerns the electric power demand in 2050. It examines the three non nuclear sectors of production: the natural gas combined cycle power plants, the wind turbines among the renewable energies and the cogeneration electric power - heat in the ternary and building sector. The necessity of the network adaptation to the european competition and the decentralized production of electric power will suppose new investments of transport and storage. (A.L.B.)

  4. For a nuclear waste law in Tunisia; Pour un droit des dechets nucleaires en Tunisie

    Energy Technology Data Exchange (ETDEWEB)

    Bouraoui, S. [Tunis Univ. (Tunisia). Faculte des Sciences

    1996-10-01

    This paper deals with the organization of the tunisian laws as far as radioactive wastes are concerned. Throughout the examples of domestic, industrial and dangerous wastes in general, the regulation system is described with its main objectives and its weaknesses. (TEC).

  5. Institutional system for the nuclear activities regulations; Cadre institutionnel pour la reglementation des activites nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Aissa, M.

    1996-10-01

    This paper points out the necessity of the laying down of regulations and institutions in the field of nuclear energy, due to the diversity of nuclear activities. Therefore different laws have been elaborated dealing with the use of nuclear energy and techniques, the control of nuclear facilities, the management and the transport of radioactive wastes and civil liability in nuclear damage. (TEC).

  6. Reflection on penal policy in nuclear matters; Reflexion sur la politique penale en matiere nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Cisse, A. [Tunis Univ. (Tunisia). Faculte des Sciences

    1996-10-01

    This document expresses ethical reflexions as far as nuclear energy development is concerned. The potential diversion of the peaceful use of nuclear energy results in the necessity of a criminal policy which would control the nuclear regulations. For each potential nuclear infringement, systems of laws are established either to prevent damages or to penalize them. (TEC).

  7. The nuclear energy: law and fear; Le nucleaire: droit et peur

    Energy Technology Data Exchange (ETDEWEB)

    Mezghani, A. [Tunis Univ. (Tunisia). Faculte des Sciences

    1996-10-01

    This document mentions the feeling of fear which goes along the idea of nuclear energy, as well as ethics and law. Technological aspects, political choices and financial matters are responsible for the nuclear energy development. Then it is shown that the consequences of this development is the continuous feeling of fear and risk which goes with every nuclear activities. (TEC).

  8. Nuclear organizations in France - USA - Japan; Organisations nucleaires France - USA- Japon

    Energy Technology Data Exchange (ETDEWEB)

    David, J.L.

    1996-10-01

    After an history of the nuclear events of the post-war period in the world, the nuclear organization in three different countries is developed. First, the case of France is described with a chronological account of events, as well as the intern and international laws. Then, the importance of nuclear energy in the electricity production in the USA is put forward. Finally, the nuclear organization in Japan is presented in the same way. (TEC). 4 figs., 1 tab.

  9. Radiation protection in nuclear facilities; Dossier: Radioprotection et installations nucleaires de base

    Energy Technology Data Exchange (ETDEWEB)

    Piechowski, J. [Direction Generale de la Sante, 75 - Paris (France); Lochard, J.; Lefaure, Ch.; Schieber, C.; Schneider, Th [Centre d`Etude sur l`evaluation de la protection dans le domaine nucleaire (CEPN), 75 - Paris (France); Lecomte, J.F. [CEA Fontenay-aux-Roses, 92 (France). Inst. de Protection et de Surete Nucleaire; Massuelle, M.H.; Hubert, Ph. [CEA Fontenay-aux-Roses, 92 (France). Inst. de Protection et de Surete Nucleaire, Dept. de Protection de la Sante de l`Homme et de la Dosimetrie (DPHD); Delmont, D. [CEA Grenoble, 38 (France). Service de Protection contre les Rayonnements et de Surveillance de l`Environnement (SPRSE); Boitel, S.; Le Fauconnier, J.P. [CEA Centre d`Etudes de Valduc, 21 - Is-sur-Tille (France). Dept. de Support Technique et Administratif; Kalimbadjian, J. [Cogema la Hague, 50 (France). Service de Prevention et de Radioprotection; Laize, J. [Cogema la Hague, 50 (France). Groupe Radioprotection atelier T7; Blain, A. [Framatome, 69 - Lyon (France). Dept. Radioprotection Securite des Services Nucleaires; Cassou, M. [Electricite de France (EDF), 13 - Marseille (France). Projet RGV; Jacq, V.; Champion, D. [Ministere de l`Industrie, des Postes et Telecommunications et du Commerce Exterieur, 75-Paris (France). Direction de la Surete des Installations Nucleaires; Spira, A.; Bouton, O. [Institut National de la Sante et de la Recherche Medicale (INSERM), Paris-11 Univ. (France); Sugier, A [CEA Fontenay-aux-Roses, 92 (France). Inst. de Protection et de Surete Nucleaire; Bishop, A.J. [Commission de Controle de l`Energie Atomique, 75 - Paris (France); Zerbib, J.C. [Conseil superieur de la Surete et de l`information Nucleaires, 75 - Paris (France); Barbey, P. [Association pour le Controle de la Radioactivite dans l`Ouest, ACRO (France)

    1998-06-01

    Close ties exist between nuclear safety and radiation protection. Nuclear safety is made up of all the arrangements taken to prevent accidents occurring in nuclear facilities, these accidents would certainly involved a radiological aspect. Radiation protection is made up of all the arrangements taken to evaluate and reduce the impact of radiation on workers or population in normal situations or in case of accident. In the fifties the management of radiological hazards was based on the quest for minimal or even zero risk. This formulation could lead to call some activities in question whereas the benefits for the whole society were evident. Now a new attitude more aware of the real risks and of no wasting resources prevails. This attitude is based on the ALARA principle whose purpose is to maintain the exposure to radiation as low as reasonably achievable taking into account social and economic concerns. This document regroups articles illustrating different aspects of the radiation protection in nuclear facilities such as a research center, a waste vitrification workshop and a nuclear power plant. The surveillance of radiological impacts of nuclear sites on environment is examined, a point is made about the pending epidemiologic studies concerning La Hague complex. (A.C.) 20 refs.

  10. Front end of the nuclear fuel cycle; Amont du cycle du combustible nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Leroux, S.; Gueneau, C.; Le Ny, J.; Camel, D.; Drevet, B.; Granier, J.; Doneddo, F.; Roblin, P.; Van Wambeke, C.; Bouty, O.; Michel, N.; Thro, P.U.; Dupuy, P.; Farcage, D.; Schildknecht, J.; Lompre, L.A.; L' Hermite, D.; Comte, M.; Gobert, O.; De Lamare, J

    1999-07-01

    In this chapter of the DCC 1999 scientific report, the following theoretical studies are detailed: condensation and flow of a binary metallic alloy in a two phase domain, a model of gas centrifuge separative performance called TRYPHON, an estimation of electron gun cathodes erosion. It also provides technological developments and instrumentation studies: a power improvement of diode-pumped solid state lasers, measurement using intracavity near resonant propagation in atomic vapours. (A.L.B.)

  11. Nuclear disarmament: France as a model; Desarmement nucleaire: prendre la France pour modele

    Energy Technology Data Exchange (ETDEWEB)

    Wodka-Gallien, Philippe [Institut francais d' analyse strategique, 12-14 rue du general Niox, 75016 Paris (France)

    2012-02-15

    The path taken by the French nuclear weapon programme shows unceasing pragmatism combined with a will to maintain the deterrence capability of the arsenal and the position it accords the country in the world's strategic structure. The abolition recommended by the US President would leave military matters open to conventional superpowers

  12. Nuclear or radiology: which term to use?; Nucleaire ou radiologique: quel terme utiliser?

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    This document brings information and definition to help the public in the distinction between the two terms: nuclear and radiologic. What means the words nuclear and radiologic in the physics and common languages? In which situation an accidental or malevolent event can be called nuclear or radiologic? By which technic and for which use is concerned the radiology? It concludes by recommendation for the choice of one or the other term. (A.L.B.)

  13. The nuclear risk: Chernobylsk eight years after. Le risque nucleaire: Tchernobyl huit ans apres

    Energy Technology Data Exchange (ETDEWEB)

    Giraud, R.

    1994-01-01

    When Chernobylsk-4 reactor explodes in april 1986, more than 1.8*10[sup +18] becquerels were disseminated around. Effects on human populations show that thyroid cancers, leukemias, stress effects (increase of drugs and alcohol consumption, psychosomatic troubles...) strongly growth, and that low radiation doses carry a deregulation of lipids metabolism. A new sarcophagus must be built. Treatment of radioactive wastes (350.000 m[sup 3]) was done in urgency and must be done now or put in the new sarcophagus. And there are in the ex-USSR 15 high risks reactors. (A.B.). 5 refs., 9 photos.

  14. The nuclear energy: an ecological solution?; L'energie nucleaire: solution ecologique?

    Energy Technology Data Exchange (ETDEWEB)

    Lung, M.; Comby, B. [Societe Generale pour les Techniques Nouvelles (SGN), 78 - Saint-Quentin-en-Yvelines (France)

    2001-10-01

    In the future the developing countries energy needs will increase considerably. How this demand can be satisfy with a protection policy of the environment and of the future generations? Some solutions are proposed with a special interest for the nuclear energy. (A.L.B.)

  15. Chinon nuclear facilities. 2009 annual report; Installations nucleaires de Chinon. Rapport annuel 2009

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This annual report is established on account of article 21 of the 2006-686 French law from June 13, 2006, relative to the transparency and safety in the nuclear domain. It describes, first, the nuclear facilities of Chinon, and then the measures taken to ensure their safety (personnel radioprotection, actions implemented for nuclear safety improvement, organisation in crisis situation, external and internal controls, technical assessment of the facilities, administrative procedures carried out in 2009), incidents and accidents registered in 2009, radioactive and chemical effluents released by the facilities in the environment, other pollutions, management of radioactive wastes, and, finally, the actions carried out in the domain of transparency and public information. A glossary and the viewpoint of the Committee of Hygiene, safety and working conditions about the content of the document conclude the report. (J.S.)

  16. Report transparency and nuclear safety 2007 CEA Grenoble; Rapport transparence et securite nucleaire 2007 CEA Grenoble

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Grenoble for the year 2007. Since 2002 the Passage project aims to realize the decontamination and the dismantling of old nuclear installations of the CEA Grenoble. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the year 2007 saw two main steps of the Passage project: the decommissioning of the Siloette reactor, a public consultation about the Lama laboratory dismantling. (A.L.B.)

  17. Report transparency and nuclear safety 2007 CEA Marcoule; Rapport transparence et securite nucleaire 2007 CEA Marcoule

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Marcoule for the year 2007. Since its creation in 1955 the center realizes industrial and scientific activities relative to the civil and military applications of the radioactivity. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the following two base activities are detailed: Atalante and Phenix. (A.L.B.)

  18. Report transparency and nuclear safety 2007 CEA Cadarache; Rapport transparence et securite nucleaire 2007 CEA Cadarache

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Cadarache for the year 2007. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the report discusses the beginning of the RJH reactor construction, the fourth generation reactors research programs, the implementing of la Rotonde the new radioactive wastes management installation, the renovation of the LECA. (A.L.B.)

  19. The nuclear in Italy - state of the art; Le nucleaire en Italie - etat des lieux

    Energy Technology Data Exchange (ETDEWEB)

    Schifano, F.; Ziller, T

    2007-02-15

    This report aims to evaluate the italian situation in matter of the nuclear, following the referendum of 1987 which decided to stop the nuclear power plants in the country. The first part is devoted to the historical aspects of the nuclear sector in Italy. The second chapter presents the institutional and legislative framework. The third chapter discusses the today situation and the italian actors of the nuclear, from the radioactive wastes management and the dismantling of nuclear installations to the engineering service realized in other countries. It discusses also the research and development programs. The last chapter proposes perspectives of the debate around a possible restart of the nuclear activity in Italy.

  20. Nuclear medicine and non Hodgkin malignant lymphomas; Medecine nucleaire et lymphomes malins non hodgkiniens

    Energy Technology Data Exchange (ETDEWEB)

    Solary, E.; Chatal, J.F. [Institut National de la Sante et de la Recherche Medicale, INSERM U517- IFR 100, 21- Dijon (France); Institut National de la Sante et de la Recherche Medicale, INSERM U- IFR 26, 44 - Nantes (France)

    2002-10-01

    The radioimmunotherapy of non Hodgkin lymphoma is a new step in the clinical development of the internal radiotherapy in nuclear medicine. It opens the door to the more difficult and still uncertain application to solid tumors. (N.C.)

  1. Nucleaire et Energies Nr 67 - December 2015. COP21: diplomatic success, a first step

    International Nuclear Information System (INIS)

    Lenail, Bernard; Ducroux, Guy; Salanave, Jean-Luc; Seyve, Claude; Simonnet, Jacques; Justin, Francois; Salanave, Jean-Luc; Darricau, Aime; Raisonnier, Daniele; Deleigne, Francoise; Lepine, Gerard; Witkowski, Didier; Knoche, Philippe

    2015-12-01

    After a first article which comments the results of the Paris Climate Conference (COP21), two articles address recent evolutions in the energy sector: an overview of recent evolutions (perspective for oil reserves, relationship between Gazprom and the EU, news about wind and solar energy in Europe, India, and in France with the most powerful European photovoltaic installation near Bordeaux, electricity prices, reduction of taxes on solar and wind energy foreseen for 2017), and a comparison between renewable energies and the EPR in terms of investment profitability. Three articles concern nuclear activities: recent events about reactors (IAEA forecast, situation and debates in France, Belgium, UK, Sweden, Romania, Slovenia, Russia, Ukraine, Iran, Emirates, Egypt, China, South Korea, Japan, and USA, cooperation between Argentina and China), about the back-end of the fuel cycle and decommissioning activities (activities and situation of different French facilities, activities and contracts in Japan, UK, USA, Taiwan, China, Finland, India and Spain), and the content of the IAEA report on the Fukushima accident. Articles comment issues concerning the relationship between nuclear and society: a comment about the use of the term 'green' and on what is green in nuclear, the recent evolutions negotiations on the issue of the Iranian nuclear industry with respect to non-proliferation, and a comment of the perception of climate change by French people as expressed by different surveys. A last article outlines that Areva will remain a world leader on the long term

  2. Quantitative dosing by nuclear magnetic resonance; Dosages quantitatifs par resonance magnetique nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Solomon, I. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    The measurement of the absolute concentration of a heavy water reference containing approximately 99.8 per cent of D{sub 2}O has been performed, by an original magnetic resonance method ('Adiabatic fast passage method') with a precision of 5.10{sup -5} on the D{sub 2}O concentration. (author) [French] La determination du titre absolu d'une eau lourde etalon de teneur approximative de 99,8 pour cent de D{sub 2}O a pu etre effectuee par une methode originale de resonance magnetique ('Methode de passage rapide adiabatique') a une precision de 5.10{sup -5} sur le titre de D{sub 2}O. (auteur)

  3. Situation of nuclear industry in Japan; La situation du nucleaire au Japon

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-03-01

    This document presents the situation of nuclear industry in Japan: cooperation with France in the domain of the fuel cycle (in particular the back-end) and of for the industrial R and D about fast reactors and nuclear safety; present day situation characterized by a series of incidents in the domain of nuclear safety and by an administrative reorganization of the research and safety organizations; power of local representatives, results of April 2003 elections, liberalization of the electric power sector, impact of the TEPCO affair (falsification of safety reports) on the nuclear credibility, re-start up of the Monju reactor delayed by judicial procedures, stopping of the program of MOX fuel loading in Tepco's reactors, discovery of weld defects in the newly built Rokkasho-mura reprocessing plant, an ambitious program of reactors construction, the opportunity of Russian weapons dismantling for the re-launching of sodium-cooled fast reactors; the competition between France and Japan for the setting up of ITER reactor and its impact of the French/Japanese partnership. (J.S.)

  4. Radiopharmaceutical projects of CNESTEN (Centre National de l'Energie, des Sciences et des Techniques Nucleaires)

    International Nuclear Information System (INIS)

    2000-01-01

    In nuclear medicine, the prescriptions of isotopic investigations are increasing because they can provide early information about morphological anomalies and permit,so to avoid long and onerous treatments. Until now, Morocco imports the radiopharmaceuticals in spite of the difficulties related to administrative procedures. To facilitate these procedures CNESTEN has launched a project which involves the following activities: - Import and distribution of needed radiopharmaceuticals; - development and production of new radiopharmaceutical kits in cooperation with scientific partners. Priority is given to the most prescribed radiopharmaceuticals. Many kits have been produced with manufacturing protocol modifications aiming to improve and optimize the production processes. The quality of the obtained products is tested and their biodistribution kinetics are studied. (F.M.)

  5. The control of hospital wastes - 'ACROnic du nucleaire' nr 86, September 2009

    International Nuclear Information System (INIS)

    2009-09-01

    This article first describes how radioactive elements are used in hospital and research departments: in nuclear medicine (for radiotherapy, in vivo diagnosis), in isotopic analysis laboratories, in research laboratories. It indicates the nature and characteristics of frequently used radio-elements (type of emission, maximum energy, percentage of emission, period). It evokes the regulation related to waste management, and comments the assessment of controls of effluents of hospitals as they have been performed by the ACRO (variation in time during the day, technetium activity, iodine 131 activity, indium 111 activity from 2004 to 2008, other detected radionuclides). It discusses the impact on the environment (in waterways)

  6. The French nuclear program: national prospects, international cooperation; Le programme nucleaire francais: perspectives nationales, cooperations internationales

    Energy Technology Data Exchange (ETDEWEB)

    Lacoste, A. [Direction de la Surete des Installations Nucleaires (DSIN), 75 - Paris (France); Joint-Lambert, V.; Breard, G.; Jolly, B. [FRAMATOME, 92 - Paris-La-Defense (France); Durret, L.F.; Capus, G.; Lebastard, G. [Cogema, 78 - Velizy-Villacoublay (France); Ouzounian, G. [Agence Nationale pour la Gestion des Dechets Nucleaire, ANDRA, 92 - Chatenay-Malabry (France); Bouteille, F. [Nuclear Power International, (Country Unknown); Appell, B. [Electricite de France (EDF), 92 - Courbevoie (France). Service Etudes et Projets Thermiques et Nucleaires; Baret, J.P.; Esteve, B. [Electricite de France (EDF), 75 - Paris (France); Peyran, J.C. [Fragema, 69 - Lyon (France); Monnet, F. [Technicatome, Centre d`Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France); Caoul, A. [CNESTEN, (Morocco)

    1998-08-01

    This issue, with a foreword by Christian Pierret, the French Secretary of State of Industry, is bilingual (French/English). It gives a thorough overview of the French nuclear industry: present situation, expected evolutions; some typical cooperations with others countries throughout the world. It contains a leaflet in which advertisers give some information about their products and services. (author)

  7. The wastes of nuclear fission; Les dechets de la fission nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Doubre, H. [Paris-11 Univ., Centre de Spectrometrie Nucleaire et de Spectrometrie de Masse, IN2P3/CNRS, 91 - Orsay (France)

    2005-07-01

    In this paper the author presents the problems of the radioactive wastes generated by the nuclear fission. The first part devoted to the fission phenomenon explains the incident neutron energy and the target nuclei role. The second part devoted to the nuclear wastes sources presents the production of wastes upstream of the reactors, in the reactors and why these wastes are dangerous. The third part discusses the radioactive wastes management in France (classification, laws). The last part details the associated research programs: the radionuclides separation, the disposal, the underground storage, the transmutation and the thorium cycle. (A.L.B.)

  8. Coarse-grained molecular dynamics simulation of transport through the nuclear pore complex

    NARCIS (Netherlands)

    Ghavami, Ali

    2014-01-01

    Dit proefschrift is gewijd aan het mechanisme van Nucleo - cytoplasmatisch transport openbaren door grofkorrelige moleculaire dynamica simulaties van ontvouwen eiwitten in de nucleaire porie complex (NPC) . NPC's zijn zeer selectief poorten, die alle transporten over nucleaire envelop controleren .

  9. Soubor kostí z časně eneolitického objektu v Suchomastech, okr. Beroun

    Czech Academy of Sciences Publication Activity Database

    Kyselý, René

    2015-01-01

    Roč. 19, č. 2 (2015), s. 505-506 ISSN 1214-3553 Institutional support: RVO:67985912 Keywords : archaeozoology * Copper Age * cattle (Bos) * Jordanów culture Subject RIV: AC - Archeology, Anthropology, Ethnology

  10. Increase of doses delivered to patients during medical imagery examinations. Conclusions of 16 September 2010 seminar organized by the ASN

    International Nuclear Information System (INIS)

    2011-01-01

    This document reports the contributions of the participants to the seminar which aimed at discussing the increase of doses delivered in medical imagery, and the actions to undertake to limit this increase. The authors recall the regulatory and legal context regarding the optimization of medical procedures and the organisation of radiation protection for medical exposures, comment the assessment of exposures by medical imagery in 2007, comment the CE marking of medical devices, the recent evolutions in dose optimization of radiology and scanography devices. Other sets of interventions address the application of the justification and optimization principle by professionals (in new scanography practices, in radio-paediatrics), the professional training issue (radiologist continuous training, electro-radiology operator training), the comparison between scanner and RMI (new fields for RMI, imagery benchmark), the assessment of professional practices (tools for continuous professional development of health professionals, medical imagery initiatives in Belgium), and international recommendations (by the IAEA, the WHO, the European Union)

  11. Problém Barák: Neruda z pohledu současné stylometrie

    Czech Academy of Sciences Publication Activity Database

    Plecháč, Petr; Flaišman, Jiří

    2017-01-01

    Roč. 65, č. 5 (2017), s. 743-769 ISSN 0009-0468 R&D Projects: GA ČR(CZ) GA14-31160S Institutional support: RVO:68378068 Keywords : stylometry * authorship attribution * textual criticism * Barák, Josef * Neruda, Jan Subject RIV: AJ - Letters, Mass-media, Audiovision OBOR OECD: Specific literatures

  12. Novo-viktoriánský román: současný trend britské fikce

    OpenAIRE

    Szilágyiová, Ester

    2010-01-01

    In 1966 when Jean Rhys wrote Wide Saragasso Sea no one would have guessed that she was starting a new literary movement whose very essence dwelled in re-thinking and rewriting Victorian myths and stories which Sally Shuttleworth named the retro-Victorian novel1. As a matter of fact, John Fowles's The French Lieutenant's Woman published in 1969, brought to public attention the parody of Victorian social, sexual and literary conventions2 but it was really in the 1980's and 1990's that many Brit...

  13. Současný výskyt enterobiózy u dětí

    OpenAIRE

    BREUOVÁ, Dora

    2013-01-01

    Enterobius vermicularis (pinworm) is one of the most common nematodes in the world.Adult worms multiply in the large intestine. Gravid female pinworms migrate to the rectum, where they lay eggs on the skin around the anus.The disease caused by pinworm is called enterobiosis. Small children specially are suffering from this disease. There is no association with world areas or social groups. Enterobiosis is transmitted by faecal-oral route. Eggs are transmitted either through contaminated hands...

  14. Liberalismus a jeho odůvodnění v současné politické filosofii

    OpenAIRE

    Cíbik, Matej

    2015-01-01

    This thesis attempts to answer one basic question: what we can philosophically say to justify liberalism as a mode of political existence of society. It is divided into three parts. In the first one, I critically survey two popular answers to this question, employing the concepts of self- ownership and value pluralism respectively. I argue that both of them are inadequate and unsatisfactory, mostly because they operate with a conception of person that is too thin for the justificatory task. I...

  15. Natural Orifice Transluminal Endoscopic Surgery (NOTES) - současný stav, vlastní zkušenosti

    Czech Academy of Sciences Publication Activity Database

    Ryska, O.; Martínek, J.; Doležel, R.; Filípková, T.; Juhás, Štefan; Juhásová, Jana; Zavoral, M.; Ryska, M.

    2011-01-01

    Roč. 65, č. 5 (2011), s. 264-271 ISSN 1210-7824 R&D Projects: GA MZd NS9994 Institutional research plan: CEZ:AV0Z50450515 Keywords : NOTES * endoscopy * minimal invasive surgery Subject RIV: FJ - Surgery incl. Transplants

  16. Antonín Randa očima svých současníků

    Czech Academy of Sciences Publication Activity Database

    Velek, Luboš

    2016-01-01

    Roč. 155, č. 8 (2016), s. 673-688 ISSN 0231-6625 Institutional support: RVO:67985921 Keywords : Randa, Antonín * Faculty of Law, Czech University in Prague * Habsburg Monarchy, 1848-1918 Subject RIV: AB - History

  17. Bohuslav Havránek očima svých současníků

    Czech Academy of Sciences Publication Activity Database

    Dvořáčková, Věra

    2017-01-01

    Roč. 9, č. 1 (2017), s. 22-38 ISSN 1804-1221 R&D Projects: GA ČR(CZ) GA17-22085S Institutional support: RVO:67985921 Keywords : structuralism * Bohuslav Havránek Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

  18. Hodnocení současných vztahů mezi ČR a SRN

    Czech Academy of Sciences Publication Activity Database

    Houžvička, Václav

    2004-01-01

    Roč. 2, č. 1 (2004), s. 3-4 ISSN 1214-4622 R&D Projects: GA AV ČR IBS7028301 Institutional research plan: CEZ:AV0Z7028912 Keywords : Czech Republic * Germany * trends of relations Subject RIV: AD - Politology ; Political Sciences

  19. Simultaneous Assessment of Asp Isomerization and Asn Deamidation in Recombinant Antibodies by LC-MS following Incubation at Elevated Temperatures

    Science.gov (United States)

    Diepold, Katharina; Bomans, Katrin; Wiedmann, Michael; Zimmermann, Boris; Petzold, Andreas; Schlothauer, Tilman; Mueller, Robert; Moritz, Bernd; Stracke, Jan Olaf; Mølhøj, Michael; Reusch, Dietmar; Bulau, Patrick

    2012-01-01

    The degradation of proteins by asparagine deamidation and aspartate isomerization is one of several chemical degradation pathways for recombinant antibodies. In this study, we have identified two solvent accessible degradation sites (light chain aspartate-56 and heavy chain aspartate-99/101) in the complementary-determining regions of a recombinant IgG1 antibody susceptible to isomerization under elevated temperature conditions. For both hot-spots, the degree of isomerization was found to be significantly higher than the deamidation of asparagine-(387, 392, 393) in the conserved CH3 region, which has been identified as being solvent accessible and sensitive to chemical degradation in previous studies. In order to reduce the time for simultaneous identification and functional evaluation of potential asparagine deamidation and aspartate isomerization sites, a test system employing accelerated temperature conditions and proteolytic peptide mapping combined with quantitative UPLC-MS was developed. This method occupies the formulation buffer system histidine/HCl (20 mM; pH 6.0) for denaturation/reduction/digestion and eliminates the alkylation step. The achieved degree of asparagine deamidation and aspartate isomerization was adequate to identify the functional consequence by binding studies. In summary, the here presented approach greatly facilitates the evaluation of fermentation, purification, formulation, and storage conditions on antibody asparagine deamidation and aspartate isomerization by monitoring susceptible marker peptides located in the complementary-determining regions of recombinant antibodies. PMID:22272329

  20. Asistovaná reprodukce z hlediska církevní nauky a současné praxe

    OpenAIRE

    Kopová, Vlasta

    2009-01-01

    Anglická anotace CHARLES UNIVERSITY IN PRAGUE Catholic Theological Faculty Department of Theological Ethics and Theology of Spirituality Author: Vlasta Kopová Title: The assisted reproduction from the aspect of ecclesiastic theory and present day experience Thesis advisor: PhDr. Libor Ovečka, ThD. PRAGUE 2008 Annotation: The aim of this work is to find theological, psychological and moral contexts of the problems of artificial insemination from the viewpoint of patente. First is there written...

  1. Současné eucharistické modlitby Církve československé husitské

    OpenAIRE

    Chytil, Petr

    2006-01-01

    Liturgy of Farský from 1924 was a very modern and successful reform of liturgy in that historic period. Modified liturgy of Farský has been used in Czechoslovak Hussite Church up to now. Meanwhile liturgy underwent the essential development of liturgical studies and liturgical practices in western churches (2. Vatican council and the renewal movement in other churches). Liturgical renewal was inspired by old Christian patterns. Although Liturgy of Farský was revised several times, principal c...

  2. Současná porodní a poporodní praxe v ČR

    Czech Academy of Sciences Publication Activity Database

    Hašková, Hana

    2000-01-01

    Roč. 1, č. 4 (2000), s. 13-15 ISSN 1213-0028 R&D Projects: GA AV ČR IBS7028002 Institutional research plan: CEZ:AV0Z7028912 Keywords : obstetrics * childbirth * sociological survey Subject RIV: AO - Sociology, Demography

  3. Filmový kýč v současné české kinematografii

    OpenAIRE

    Peňásová, Anna

    2011-01-01

    The subject of this bachelor's thesis is aimed at the role of kitsch in contemporary Czech cinematography. The result should answer the question, if the film popularity is connected with its kitsch or not, and mainly what is the position of kitsch in contemporary Czech film. The theoretic part summarizes definitions of kitsch and outlines the situation in contemporary Czech motion picture industry. The practical part is comprised of analysis of top ten the most popular Czech films from 2010 g...

  4. Město a současná religiozita v pohledu sociologie náboženství

    Czech Academy of Sciences Publication Activity Database

    Nešpor, Zdeněk

    2016-01-01

    Roč. 11, č. 3 (2016), s. 78-91 ISSN 1211-7668 R&D Projects: GA ČR(CZ) GA14-15008S Institutional support: RVO:68378025 Keywords : Sociology of religion * urban sociology * city and religion Subject RIV: AA - Philosophy ; Religion

  5. Effect of active-site mutation at Asn67 on the proton transfer mechanism of human carbonic anhydrase II.

    Science.gov (United States)

    Maupin, C Mark; Zheng, Jiayin; Tu, Chingkuang; McKenna, Robert; Silverman, David N; Voth, Gregory A

    2009-08-25

    The rate-limiting proton transfer (PT) event in the site-specific mutant N67L of human carbonic anhydrase II (HCA II) has been examined by kinetic, X-ray, and simulation approaches. The X-ray crystallography studies, which were previously reported, and molecular dynamics (MD) simulations indicate that the proton shuttling residue, His64, predominantly resides in the outward orientation with a significant disruption of the ordered water in the active site for the dehydration pathway. While disorder is seen in the active-site water, water cluster analysis indicates that the N67L mutant may form water clusters similar to those seen in the wild-type (WT). For the hydration pathway of the enzyme, the active site water cluster analysis reveals an inability of the N67L mutant to stabilize water clusters when His64 is in the inward orientation, thereby favoring PT when His64 is in the outward orientation. The preference of the N67L mutant to carry out the PT when His64 is in the outward orientation for both the hydration and dehydration pathway is reasoned to be the main cause of the observed reduction in the overall rate. To probe the mechanism of PT, solvent H/D kinetic isotope effects (KIEs) were experimentally studied with catalysis measured by the exchange of (18)O between CO(2) and water. The values obtained from the KIEs were determined as a function of the deuterium content of solvent, using the proton inventory method. No differences were detected in the overarching mechanism of PT between WT and N67L HCA II, despite changes in the active-site water structure and/or the orientation of His64.

  6. O minulé a současné reflexi vědomí společnosti

    Czech Academy of Sciences Publication Activity Database

    Mišovič, Ján

    2002-01-01

    Roč. 34, č. 4 (2002), s. 287-304 ISSN 0049-1225 Institutional research plan: CEZ:AV0Z7028912 Keywords : social consciousness * Wold-view * common sense Subject RIV: AO - Sociology, Demography Impact factor: 0.138, year: 2002

  7. Současná pojetí vztahu mezi pozorností a vědomím

    Czech Academy of Sciences Publication Activity Database

    Špok, Dalibor

    2004-01-01

    Roč. 48, č. 1 (2004), s. 38-51 ISSN 0009-062X Institutional research plan: CEZ:AV0Z7025918 Keywords : attention * consciousness * automatic processes Subject RIV: AN - Psychology Impact factor: 0.209, year: 2004

  8. Pracovní migrace a remitence. Současné trendy v době ekonomické krize

    Czech Academy of Sciences Publication Activity Database

    Stojanov, Robert; Strielkowski, Wadim; Drbohlav, D.

    2011-01-01

    Roč. 116, č. 4 (2011), s. 375-400 ISSN 1212-0014 R&D Projects: GA MŠk(CZ) ED1.1.00/02.0073 Institutional research plan: CEZ:AV0Z60870520 Keywords : international migration * remittances * economic crisis * imigration surplus Subject RIV: AO - Sociology, Demography Impact factor: 1.021, year: 2011

  9. Cestovní ruch v Peru: vývoj, současný stav, vize

    OpenAIRE

    Pošepná, Zdeňka

    2009-01-01

    This thesis deals with development of tourism in Peru from the 19. century to the present-day by means of travel accounts written by travellers mainly from Europe and United States of America. Furthermore, the thesis analyzes present development of tourism in Peru. At first it evaluates today's Peruvian offer of tourist attractions presented by Peruvian guidebooks which compares with demand for these attractions trough the medium of contemporary foreign guidebooks. This analyze is completed b...

  10. Mikrosatelity - jejich funkce, význam a použití v současné biologii

    Czech Academy of Sciences Publication Activity Database

    Mandák, Bohumil

    2011-01-01

    Roč. 46, Mat.25 (2011), s. 79-94 ISSN 1212-3323. [Evoluční aspekty biologie rostlin. Praha, 27.11.2012-28.11.2010] R&D Projects: GA ČR(CZ) GAP504/11/0402 Institutional research plan: CEZ:AV0Z60050516 Keywords : microsatellites * codominant marker * gene flow Subject RIV: EF - Botanics

  11. Mikrosatelity - jejich funkce, význam a použití v současné biologii

    Czech Academy of Sciences Publication Activity Database

    Mandák, Bohumil

    2011-01-01

    Roč. 46, Mat. 25 (2011), s. 79-94 ISSN 1212-3323 R&D Projects: GA ČR(CZ) GAP504/11/0402 Institutional research plan: CEZ:AV0Z60050516 Keywords : microsatellites * codominant marker * gene flow Subject RIV: EF - Botanics

  12. Současná pozice cestovního ruchu ve světové ekonomice

    OpenAIRE

    Kadlecová, Anna

    2017-01-01

    The diploma thesis deals with the current position of tourism in the global economy. The work focuses on the regional layout of international tourism in terms of international arrivals, international tourism receipts and international tourism expenses. An emphasis is also put on the economic importance of tourism, mainly in relation to GDP, employment, price stability and balance of payment. The thesis is also focused on current issues in the field of international tourism - shared economy, C...

  13. Activation of an Asp-124→Asn mutant of haloalkane dehalogenase by hydrolytic deamidation of asparagine

    NARCIS (Netherlands)

    Pries, Frens; Kingma, Jacob; JANSSEN, Dick B

    1995-01-01

    Haloalkane dehalogenase hydrolyses various 1-halon-alkanes to the corresponding alcohols by covalent catalysis with formation of an alkyl-enzyme intermediate. The carboxylate function of the nucleophilic aspartate (Asp-124) that displaces the halogen during formation of the intermediate was changed

  14. Dopady dočasných změn valorizace důchodů

    Czech Academy of Sciences Publication Activity Database

    Janský, Petr

    -, č. 3 (2014), s. 67-78 ISSN 1212-415X Institutional support: RVO:67985998 Keywords : pension indexation * impact evaluation * Czech Republic Subject RIV: AH - Economics http://www.slu.cz/opf/cz/informace/acta-academica-karviniensia/casopisy-aak/aak-rocnik-2014/docs-3-2014/Jansky.pdf

  15. Akademický slovník současné češtiny

    Czech Academy of Sciences Publication Activity Database

    Kochová, Pavla; Opavská, Zdeňka

    2016-01-01

    Roč. 99, č. 2 (2016), s. 57-83 ISSN 0027-8203 R&D Projects: GA MK DF13P01OVV011 Keywords : dictionary -making principles * lexicography * dictionary macrostructure * dictionary microstructure * monolingual dictionary Subject RIV: AI - Linguistics

  16. Adventní kult Panny Marie v současné lidové tradici: Prameny z Moravy

    Czech Academy of Sciences Publication Activity Database

    Večerková, E.; Frolcová, Věra

    2008-01-01

    Roč. 56, č. 4 (2008), s. 418-431 ISSN 1335-1303 Institutional research plan: CEZ:AV0Z90580513 Keywords : advent * folk catholic devoutness * local spiritual cult ure * Virgin Mary mother of believers Subject RIV: AC - Archeology, Anthropology, Ethnology

  17. Safety and quality management for radiotherapy treatments - ASN guide nr 5 - Index 1 - Release of the 10/04/2009

    International Nuclear Information System (INIS)

    2009-01-01

    This guide aims at proposing a framework for the safety and quality management for radiotherapy treatments. It addresses the general requirements for the quality management system (general requirements and requirements related to documentation), the management responsibility, the resource management (human and hardware resources), the preparation and performance of activities allowing the taking into care of a patient from his first consultation to the post-treatment follow-up, the assessment, analysis and improvement of the quality management system

  18. Specifika současné ruské diskuse o Sovětském svazu

    Directory of Open Access Journals (Sweden)

    Zdeněk Bělonožník

    2014-06-01

    Full Text Available The aim of the article is to introduce contemporary Russian discussion on the USSR and Russia in broader political and publicist context. Both positive and negative interpretations of the Russian/Soviet history will be presented. The text does not pretend to provide exhaustive list of the particular “schools” and “movements” nor does it offer historical dynamics or institutional background of the discussion. The author rather intends to single out certain basic schemes and arguments that circulate in the discussions, place them in broader frames and anticipate their potential political consequences. Particularly, the text concentrates on various versions of the patriotic thinking that has been receiving broad popularity in today Russia. As the author is convinced, due familiarity with the contemporary Russian debate may help to better understand Russian internal as well as foreign policy nowadays: as it becomes clear, rise of patriotism in academia, society and politics are inseparable phenomena. Secondly, some of the arguments promoted by the contemporary Russian authors may enrich Western (non-Russian sovietology and debate on socialist experiments as such. Last but not least, both content and form of the Russian academic discussion convincingly point at cultural conditionality of social and historical sciences. To some extent the discussion reminds perpetual Russian debate on national identity; cardinally new context in which it takes place however justifies attention paid to it.

  19. Kongres IFAC v Praze a některé současné problémy automatizace

    Czech Academy of Sciences Publication Activity Database

    Klán, Petr

    2005-01-01

    Roč. 11, č. 3 (2005), s. 86-88 ISSN 1210-9592 Institutional research plan: CEZ:AV0Z10300504 Keywords : IFAC Congress * modern automation * solved problems Subject RIV: BD - Theory of Information http://www.odbornecasopisy.cz/index.php?id_document=30405

  20. Současné modely likvidních finančních trhů

    OpenAIRE

    Grosu, Iulia

    2012-01-01

    The aim of this paper is to provide a comprehensive overview of selected current models of liquid financial markets, namely to explain their basic principles, assess their strengths and deficiencies and compare them with each other. The thesis is divided into six chapters. The first five chapters focus on the theoretical description of five different models, including their assumptions, the resulting consequences and, where possible, their mathematical formulation. The particular chapters als...

  1. Case law

    International Nuclear Information System (INIS)

    2015-01-01

    This section treats of the following case laws: 1 - Canada: Decision of the Canadian Federal Court of Appeal overturning a decision to send back for reconsideration an environmental assessment of a proposed new nuclear power plant in Ontario; 2 - France: Council of State decision, 28 November 2014, Federation 'Reseau sortir du nucleaire' (Nuclear Phase-Out network) and others vs. Electricite de France (EDF), Request No. 367013 for the annulment of: - The resolution of the French Nuclear Safety Authority (ASN) dated 4 July 2011 specifying additional regulations for Electricite de France (EDF) designed to strengthen the reactor basemat of reactor No. 1 in the Fessenheim nuclear power plant, and - The resolution of ASN dated 19 December 2012 approving the start of work on reinforcing the reactor basemat in accordance with the dossier submitted by EDF; 3 - Germany: Judgment of the European Court of Justice on the nuclear fuel tax; 4 - India: Judgment of the High Court of Kerala in a public interest litigation challenging the constitutional validity of the Civil Liability for Nuclear Damage Act, 2010; 5 - Japan - District court decisions on lawsuits related to the restart of Sendai NPP and Takahama NPP; 6 - Poland: Decision of the Masovian Voivod concerning the legality of the resolution on holding a local referendum in the Commune of Rozan regarding a new radioactive waste repository; Certain provisions of the Regulation of the Minister of Health of 18 February 2011 on the conditions for safe use of ionising radiation for all types of medical exposure have been declared unconstitutional by a judgment pronounced by the Constitutional Tribunal; 7 - Slovak Republic: Developments in relation to the disclosure of information concerning the Mochovce nuclear power plant

  2. Survey of International Rules and Practices Regarding Delineation of and Access to Regulated Areas for Radiation Protection - Final report

    International Nuclear Information System (INIS)

    Schieber, C.; Crouail, P.; Beltrami, L.-A.; Reaud, C.; Lehtinen, Maaret; Stritt, Nicolas; Thomas, Gareth

    2013-06-01

    European requirements for radiological protection, especially work on transposing the new EURATOM Directive on the basic radiological protection standards, are currently being revised. The Direction generale du travail (DGT - General Directorate of Labour) and the Autorite de Surete Nucleaire (ASN - Nuclear Safety Authority) therefore commissioned the Radiological Protection Standing Groups of experts (GPRAD and GPMED)1 to engage in a forward-looking debate on the delimitation of and access to regulated areas, within an ad hoc working group (called hereafter 'Classification of Area WG'). To fuel its debates, the 'Classification of Area WG' sought elements on international regulations and practices focusing on problem exposure situations in various areas of activity (nuclear, industrial, research, medical, transport and natural boosted). CEPN was entrusted with this study. This report presents a summary of rules applicable in seven countries in terms of delimitation of and access to regulated radiological protection areas. The countries are: Belgium, Spain, United States, Finland, United Kingdom, Sweden and Switzerland. Detailed sheets for each country can be found in the Annex. Based on these summaries, three countries have been selected to apply their rules and practices in force to a dozen or so particular cases put together by the 'Classification of Area WG' that are representative of exposure situations. The three countries are Finland, United Kingdom and Switzerland. The case studies applied to each country are presented in the second part of this report

  3. Statement of the IRSN on the safety re-examination assessment made by EDF within the frame of the third decennial inspection of the 900 MW reactors

    International Nuclear Information System (INIS)

    2008-01-01

    The IRSN (the French Institute of Radioprotection and Nuclear Safety) here presents an assessment of the studies performed by EDF within the frame of the safety re-examination associated to the third decennial inspections of the 900 MW reactors, and of the modifications resulting from these studies with respect to the originally defined objectives of this re-examination. The aim of this report is to allow the ASN (Autorite de Surete Nucleaire, the Nuclear Safety Authority) stating the 900 MW reactor ability to carry on their operation until the fourth decennial inspections. Different themes and studies are assessed: internal and external aggressions (flooding, explosions, fire, seismic control, and climatic aggressions), accident assessments and their radiological consequences (failure of various components, the performing of probabilistic studies, confining procedures, structures and devices, etc.), operation and design of various systems and of civil engineering works. Several documents or extracts of official reports are given in appendix, expressing notably various recommendations on the here-above topics

  4. The nuclear and the energy supply of tomorrow. Stop the useless quarrels about the nuclear; Le nucleaire et l'approvisionnement energetique de demain. Cesser les querelles inutiles a propos du nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    Following the paper of Hubert Reeves which developed the reasons of the the nuclear stopping, the author presents arguments to ease this opinion ( economic growth of the developing countries, greenhouse gases reduction, fossil fuels conservation, transportation sector) and proposes a cooperation between the nuclear and the renewable energies to satisfy a sustainable development. (A.L.B.)

  5. Recycling the spent nuclear fuel actinides: a major contribution to the sustainability of the 4. generation nuclear energy systems; Le recyclage des actinides presents dans les combustibles nucleaires uses: une contribution significative pour un nucleaire du 4. generation durable

    Energy Technology Data Exchange (ETDEWEB)

    Poinssot, Ch.; Warin, D. [CEA Valrho (DEN/MAR/DRCP/DIR), 30 - Marcoule (France)

    2009-08-15

    In line with the emerging objective of sustainable development, renaissance of nuclear energy requires optimizing current nuclear fuel cycles to recycle all the potentially energetic elements which are still present within the spent nuclear fuel after their first use in reactor. That concerns basically the actinides, first of all uranium and plutonium, but also the minor actinides, which represent the most significant part of the long term radiotoxicity of the nuclear waste to be disposed off deep underground. Current R and D aims to develop chemical processes based on liquid/liquid extraction using organic molecules presenting specific affinity for actinides. This paper aims to give an overview of the recent French results and the current developments which are performed within the framework of the French Waste Management Act from 28 June 2006. (authors)

  6. Nuclear systems of the future - generation 4. Proposals of strategic orientations for the nuclear systems of the future; Les systemes nucleaires du futur - generation 4. Propositions d'orientations strategiques pour les systemes nucleaires du futur

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    Several points, specific to France, must be taken into consideration for the long term strategic choice of future nuclear systems, in particular: taking the best profit of the progress potentialities of water reactors, optimizing the opportunities offered by the renewal of power plants in operation, integrating the consequences and the implementation of a strategy of optimized management of radioactive wastes, and looking for improvements that would make nuclear energy an active contributor to sustainable development. The prospective researches carried out by the CEA and its industrial partners have led to propose a R and D strategy with 3 complementary goals: search for innovations for water reactors, development of fast neutron reactors with closed fuel cycle (sodium fast reactor (SFR), gas fast reactor (GFR)), and development of key-technologies for nuclear hydrogen production (very high temperature reactor (VHTR)). The R and D effort concerns also the subcritical systems devoted to transmutation, the new cycle processes for a global management of actinides, and some other nuclear systems like the molten salt reactors (MSR) and the supercritical water reactors (SCWR). This paper presents the R and D strategy for each technology with its priorities, steps, financial means and collaborations. (J.S.)

  7. Energy, world should not chose nuclear energy to fight against climatic change. Nuclear and climatic change; Energie, le monde ne devrait pas opter pour le nucleaire pour lutter contre le rechauffement climatique. Nucleaire et changement climatique

    Energy Technology Data Exchange (ETDEWEB)

    Besson, S

    2007-06-15

    This document proposes an abstract of the conclusions of an expert group, the Oxford Research Group, which criticizes the today boost in favor of the electricity from nuclear energy. They explain that the nuclear energy should not be a solution for the fight against the climatic change. (A.L.B.)

  8. Best-of 2001: nuclear cardiology and cardiac MRI; Le best-of 2001: cardiologie nucleaire et IRM cardiaque

    Energy Technology Data Exchange (ETDEWEB)

    Manrique, A. [Centre Hospitalier Universitaire, 76 - Rouen (France); Marie, P.Y. [Centre Hospitalier Universitaire, 54 - Nancy (France)

    2001-12-01

    This year 2001 has been very rich in innovations and in works-in-progress in the field of cardiac imaging. In nuclear cardiology, this year has been mainly impressed by a large number of studies concerning 'gated SPECT' which allows the simultaneous analysis of the perfusion and of the contraction of the left ventricle. The clinical contribution of this technique is quite significant in any of the fields of use of the conventional tomo-scintigraphy such as the screening of the coronary disease, the evaluation of its prognosis or the evaluation of the viability. Innovation has also concerned the field of the radio-tracers, with studies concerning some very promising tracers of the apoptosis or of the cellular hypoxia. At last, various works have been carried out on the gamma-cameras, particularly to make them suitable for imaging of tracers used in positron emission tomography (PET). This should allow to spread to any of the nuclear medicine centers the use of FDG imaging which is the golden standard for myocardial viability assessment. About MRI, a lot of studies have been performed about sequences using gadolinium as a vascular contrast agent, to identify and to localize the infarction sequelae, even when limited to sub-endocardium. Probably the most dramatic technical innovations concerned the development of methods enhancing the recorded signal (SENSE) and the design of real-time imaging sequences, without apnea and without ECG gating. But, as every year, important advances have also been registered in angio-MR of the coronary vessels, as in the myocardial perfusion analysis using sequences without the requirement of contrast agent injection. (author)

  9. Physics for future Presidents - nuclear power, terrorism, global warming; La physique expliquee a notre futur president - Nucleaire, terrorisme, rechauffement climatique

    Energy Technology Data Exchange (ETDEWEB)

    Muller, Richard A.

    2011-04-26

    This book explains the science behind the concerns that our nation faces in the immediate future. It outlines the tools of terrorists, the dangers of nuclear power, and the reality of global warming. As citizens who will elect future presidents of the most powerful and influential countries in the world, we need to know-truly understand if Iran's nascent nuclear capability is a genuine threat to the West, if biochemical weapons are likely to be developed by terrorists, if there are viable alternatives to fossil fuels that should be nurtured and supported by the government, if nuclear power should be encouraged, and if global warming is actually happening. This book is written in everyday, nontechnical language on the science behind the concerns that our nations faces in the immediate future. This book is translated from 'Physics for Future Presidents: The Science Behind the Headlines', published by W. W. Norton and Company in August 2008. Contents: 1 - Terrorism: Nine-eleven, Terrorist nukes, The next terrorist attack, Biological terrorism; 2 - Energy: Key energy surprises, Solar Power, The end of oil; 3 - Nukes: Radioactivity and death, Radioactive decay, Nuclear weapons, Nuclear madness, Nuclear power, Nuclear waste, Controlled fusion; 4 - Space: Space and satellites, Gravity applications, Humans in space, Spying with invisible light; 5 - Global Warming: A brief history of climate, The greenhouse effect, A very likely cause, Evidence, Non-solutions, The fruit on the ground, New technologies

  10. The Iran nuclear ambitions and the international consequences; Les ambitions nucleaires de l'Iran et leurs consequences internationales

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-01-15

    This analysis of the Iran situation concerning the nuclear policy, is presented and discussed in three parts: the data and hypothesis of the iranian nuclear program, the regional strategy of Iran and evolution scenario and their consequences. (A.L.B.)

  11. An exercise of pluralistic expertise about the Limousin uranium mines - 'ACROnique du nucleaire' nr 84, March 2009

    International Nuclear Information System (INIS)

    Barbey, Pierre

    2009-03-01

    After having recalled the context of creation of a GEP (a pluralistic group of expertise) for the uranium mines located in the Limousin region, and indicated the first works performed by this group, the author more precisely defines what a GEP is. He proposes a brief overview of the history of uranium mines in France and outlines that it took a long time to take the associated risks into account. He discusses the issue of management of this after-mine period. He describes how the extraction products have been managed, i.e. transported or stored. He comments the works performed by the GEP-mines, its difficulties (budget and organisation), and the activities performed about different ancient mining sites

  12. Activities report for 1994-1995; Institut de Physique Nucleaire de Lyon - Rapport d`activite 1994-1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    Here is the progress report for the Institute of Nuclear Physics of Lyon.We find physics at Lep, R and D for CMS at LHC( Higgs boson search in the L3 collaboration, quark b physics in Delphi at Lep 100,electromagnetic calorimetry for CMS-RD18 program, CMS experiment at LHC: MSGC development), hadronic and nuclear matter(heavy ions in CMS, multifragmentation threshold, spectroscopy of superdeformed nuclei with EUROGAM), astro-particles(gamma and neutron radioactive background measurements, bolometric measurement, scintillating crystal characterization for dark matter detection, the Virgo optics), ions/clusters-matter, physico-chemical transformation by ion-solid interaction are some examples of studies realized during these two years. (N.C.).

  13. The french nuclear industry is looking for an american partner; Le nucleaire francais cherche un allie americain

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    In the same time of the nuclear industry revival in USA by the President Bush, TOPCO the holding society which is going to group the main french nuclear society, is looking for an american partner. This report deals with the economic and political aspects of the situation. (A.L.B.)

  14. The nuclear energy policy challenges; Les defis de la politique en matiere d'energie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Hanne, H. [Ministere de l' Ecologie, de l' Industrie et de l' Emploi, Chef du Bureau Ameriques a la Dir. du Tresor et de la Politique Economique, 75 - Paris (France)

    2009-11-15

    At a time when the nuclear question mobilizes attentions and when a new cycle of debates about non-proliferation opens up, the author recalls the constraints and challenges of a nuclear power generation policy. After a brief history of the development of nuclear energy in France and in the rest of the world, the author presents the risks linked with this energy source (TMI and Chernobyl accidents), the particularities of the fuel cycle with its safety and security aspects, and the promises of some past and future reactor technologies (FBR's and fusion reactors). Then, the author stresses on the importance of investments in this domain as illustrated by the launching of new nuclear programs in France, UK, Italy, Finland and in the US, and by the willing of some emerging countries to develop this energy source (China, India, United Arab Emirates, Jordan..). Finally, nuclear energy must not be considered as a privilege of developed countries but should benefit to the rest of the world as well since it promotes economic development thanks to an abundant and cheap energy. (J.S.)

  15. Nuclear energy, energy of the future or bad solution?; Energie nucleaire, energie d'avenir ou fausse solution?

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    The document presents the speeches of the debate on the nuclear energy solution for the future, presented during the meeting of the 6 may in Rennes, in the framework of the National Debate on the energies. The debate concerns the risks assessment and control, the solutions for the radioactive wastes, the foreign examples and the future of the nuclear energy. (A.L.B.)

  16. About some frequent objections on the civil nuclear; A propos de quelques objections frequentes sur le nucleaire civil

    Energy Technology Data Exchange (ETDEWEB)

    Manicore, J.M

    2002-06-01

    The author brings information on the advantages of the nuclear energy for the electric power production, in the context of the energy demand increase. He tries to identify the controversy subjects and opposes arguments in favor of the nuclear energy: environment, prices, energy recovery, wastes, safety, nuclear accidents. (A.L.B.)

  17. The nuclear wastes the democracy face to technological choices; Les dechets nucleaires la democratie face aux choix technologiques

    Energy Technology Data Exchange (ETDEWEB)

    Laet, J.P. de

    1996-01-01

    In every country concerned in radioactive waste management, the technicians thought they had possible solutions but they collided with a lack of understanding and came into conflict with public. What was demanded was a true policy control of scientific and technological choices as regard wastes. The decision to build a deep storage cannot be taken without a new law: the parliament will lean on a final report in 2006, which date a decision will be taken. Until this date, studies and research program are reviewed every year. (N.C.).

  18. Some aspects of nuclear graphite production in France; Etude generale sur les graphites nucleaires produits en France

    Energy Technology Data Exchange (ETDEWEB)

    Gueron, J.; Hering, H. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Legendre, A. [Pechiney, 75 - Paris (France)

    1958-07-01

    1) Manufacturing: A summary and results on the CEA-Pechiney purification process are given. Variations in the preparation of green pastes and their effects on graphitized material are described. 2) Physical and mechanical properties: Results are given on: - Statistics of dimensional variatior products having square cross-section. - Statistical variation of thermal expansion coefficients and of electrical conductivity. - Density of normals to carbon layer planes and their connexion with thermal expansion. - Stress-strain cycles and conclusions drawn therefrom. - Mechanical resistance and gas permeability of items for supporting fuel elements. 3) Behaviour under radiation: Alteration under radiation of French graphites irradiated either in G1 pile or in experimental piles, and thermal annealing of those alterations, are given. (author)Fren. [French] 1) Fabrication: On resume le procede d'epuration CEA-PECHINEY, ainsi que diverses modalites de preparation des pates et on expose les resultats obtenus. 2) Proprietes physiques et mecaniques: On indique le resultat d'etudes sur: - la statistique des dimensions de produits a section carree. - celle des variations des coefficients de dilatation thermique et de la conductibilite electrique. - la densite des normales aux plans graphitiques et leur connexion avec la dilatation thermique. - la compression mecanique du graphite. - la solidite mecanique et la permeabilite aux gaz de pieces destinees a supporter des cartouches de combustible. 3) Tenue sous rayonnement: Modification sous rayonnement des graphites fran is irradies soit dans la pile G1, soit dans des piles experimentales, et guerison thermique de ces modifications. (auteur)

  19. On the use of optical fibre sensors in nuclear environment; Utilisation des capteurs a fibre optique en environnement nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Brichard, B. [SCK-CEN - Studiecentrum voor Kernenergie - Centre d' Etude de l' Energie Nucleaire, Belgian Nuclear Research Center, Mol (Belgium)

    2010-03-15

    This paper aims to provide a new insight on the use of optical fibre sensors for nuclear applications. We report on the possibilities for radiation resistance improvement using hydrogenation techniques as well as on the behaviour of various sensors exposed to radiation such as the distributed temperature sensor based on Raman effect, high-temperature Bragg gratings and a gamma ray monitor using Cerenkov luminescence. A short discussion regarding the radiation resistance of photonic crystal fibres is also briefly presented. (author)

  20. Nuclear magnetic resonance common laboratory, quadrennial report; Laboratoire commun de resonance magnetique nucleaire, rapport quadriennal 1994-1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    This quadrennial report of the nuclear magnetic resonance common laboratory gives an overview of the main activities. Among the different described activities, only one is interesting for the INIS database: it concerns the Solid NMR of cements used for radioactive wastes storage. In this case, the NMR is used to characterize the structure of the material and the composition, structure and kinetics of formation of the alteration layer which is formed at the surface of concrete during water leaching conditions. The NMR methodology is given. (O.M.)

  1. Progress report for 94/95; Institut des Sciences Nucleaires - Rapport d`activite 1994-1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    We find here the progress report for the two years 1994 and 1995 for institute of nuclear sciences at Grenoble. In the field of quarks and leptons, three teams are invested in CERN programmes: A.T.L.A.S. near the L.H.C., D.E.L.P.H.I; the neutrino team has achieved the building of the detector in the M.U.N.U. collaboration. In the theme Hadrons physics we have G.R.A.A.L. at E.S.R.F., C.E.B.A.F. and W.A.89. Physicists are implied in the project E.L.F.E at D.E.S.Y. The study of superdeformed states go on with E.U.R.O.G.R.A.M. New techniques have been used near the programme S.A.R.A. The programme P.I.A.F.E. saw the resolution of the difficult problem of the transformation 1+ gives N+ ions of 30 KeV and their transport on long distances. The team of hybrid reactors have shown that it was possible to amplify energy by a sub critical accelerator-reactor hybrid system, experience initiated by C. Rubbia at C.E.R.N. (N.C.).

  2. Twelve reasons to refuse the nuclear in the MDP; Douze raisons pour refuser le nucleaire dans le MDP

    Energy Technology Data Exchange (ETDEWEB)

    Bonduelle, A

    2000-07-01

    The author presents twelve reasons which show that the nuclear energy has not a place in the MDP Mechanism of Clean Development: a main loophole for the developed countries, the doubtful ''additionality'' of the nuclear, the treaty ratification is more difficult with the nuclear, the domestic energy conservation is more efficient in Europe than the nuclear development, the nuclear white elephants facing the South debts, the technology transfers are doubtful, the developing countries and the sustainable development policies are evicted from the MDP, some options are more powerful in the South, the reactors and transport networks size are unsuited, the absence of democratic control, the nuclear proliferation, the nuclear safety and the wastes. (A.L.B.)

  3. The radioactive wastes management of the little nuclear industry; La gestion des dechets radioactifs du nucleaire diffus

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    Among the ANDRA customers, more than one million are little producers: hospital, research centers and industries. They are called little producers because of the low volume of produced wastes. Meanwhile these wastes management need an appropriate technology which is presented in this document. (A.L.B.)

  4. The Japanese nuclear sector shaken up again. Japanese press review - 'ACROnic du nucleaire' nr 81, June 2008

    International Nuclear Information System (INIS)

    2008-06-01

    After having briefly recalled the earthquake which occurred in July 2007 in the Niigata province, and also some other accidents which occurred in other power plants operated by TEPCO during the previous years, the author reports what were the consequences for Kashinawaki-Kariwa nuclear power station, and how these consequences have been reported by the press and managed by the Japanese operator TEPCO. He indicates the information published by the press after the accident and those given by TEPCO two days after. He describes the problems of organization on the fire brigade side, the fact that the fire risk had been underestimated by the operator. Radioactive leakages et releases have been discovered quite late, and could have been worse because of damages caused by the earthquake to some installations and if the stopped reactors had been operating. The author describes how the storage pools overflowed and how some installations were flooded by radioactive water. He outlines that TEPCO admitted very late that the reactor cores might have been damaged. He also outlines lacks in seismic studies, and notably the fact that TEPCO detected underwater cracks and estimated they were non active. Moreover seismograph recordings have been lost after the earthquake. The author reports the concerns of several scientists about the seismic risk for the region, and about safety margins of the whole Japanese nuclear fleet. He comments the consequences of the closure of the station in terms of lack of electricity supply. He finally notices that Japanese actors of the nuclear sector (industries, public authorities), despite these problems, decided to pursue the activity of a reprocessing plant, and the construction of new reactors

  5. International conference: nuclear power for the 21 st century; Conference internationale: L'energie nucleaire au 21. siecle

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    It is widely recognised that global energy demand will rise substantially during this century. The increased industrialization and urbanization of developing countries will produce large increases in energy demand in regions that currently have very low per capita energy use. This increasing demand for energy will need to be met in order to improve living standards for at least half of the world population and to reduce the economic imbalances between countries and regions. At the same time the use of fossil fuel based energy is identified as a major cause of environmental damage. The release of greenhouse gases from burning of fossil fuel in power stations and for transport is seen as a contributor to global warming. It is widely recognised that continued exploitation of fossil fuels and release of carbon dioxide will need to be controlled. After a prolonged period of slow development of nuclear power, confined to some countries in the world, it is now being recognised that nuclear energy has a potentially significant role to play in meeting the energy needs of the planet without damaging the environment. Developments in technology make the economics of nuclear power more attractive, and they may become even more so as fossil fuel prices continue to rise.or a widespread use of nuclear power, however, there remain concerns on the safety, security, waste and proliferation aspects. The global application of safety standards and appropriate security measures are required to ensure acceptable levels of protection. Effective control measures are required to ensure that non-proliferation commitments are honored. Handling nuclear waste safely and securely is achievable, but continues to remain as a public concern. The broad strategic objectives of the Conference are the following: to review the role of nuclear power and to define the potential benefits (energy security, sustainability and improved environmental protection) that expanding nuclear power offers to meet the increasing energy needs of the world; to facilitate a discussion on the issue of nuclear energy and society involving experts and decision makers. (author)

  6. Radioactive waste: the poisoned legacy of the nuclear industry; Dechets radioactifs: l'heritage empoisonne du nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Rousselet, Y. [Campagne Climat/Energie - Greenpeace (France)

    2011-02-15

    The nuclear industry produces a huge amount of radioactive waste from one end to the other of the nuclear cycle: i.e. from mining uranium to uranium enrichment through reactor operating, waste reprocessing and dismantling nuclear power plants. Nuclear power is now being 'sold' to political leaders and citizens as an effective way to deal with climate change and ensure security of energy supplies. Nonetheless, nuclear energy is not a viable solution and is thus a major obstacle to the development of clean energy for the future. In addition to safety and security issues, the nuclear industry is, above all, faced with the huge problem of how to deal with the waste it produces and for which it has no solution. This ought to put a brake on the nuclear industry, but instead, against all expectations, its development continues to gather pace. (author)

  7. Semi-classical theory of fluctuations in nuclear matter; Theorie semi-classique des fluctuations dans la matiere nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Benhassine, B. [Nantes Univ., 44 (France)

    1994-01-14

    At intermediate energies the heavy ion collisions can be studied within the framework of a semi-classical approach based on the Vlasov-Uehling-Uhlenbeck (VUU) equation. Such an approach reduces the N-body problem to its description in terms of the one-body distribution function and constitutes the basis of several successful simulation models. Our aim in this work is to extend these average approaches to treat fluctuations. Within the framework of a linear approximation, we derived a Fokker-Planck transport equation in the one-body phase space. When it is reduced to its first moments, one recovers the VUU equation for the average dynamics together with the time evolution equation for the correlations. The collective transport coefficients are then obtained by projection on the one-body collective space. Independently, using a projection method introduced by Van Kampen, based on the constants of motion, we deduce the stationary expressions for the covariance matrix in phase space. We extract then, the equilibrium dispersions of one-body observables in a homogeneous case and in a spherical symmetric one. These results are compared with two types of simulation models in a relaxation time approximation. In the first one which is of Lagrangian type, the collective transport coefficients are directly extracted from the simulation and consequently the numerical fluctuations are washed out. The second model, due to its Eulerian character, allows us to make a microscopical comparison. (author) 58 refs.

  8. Excitations in superfluid systems: contributions of the nuclear structure; Excitations dans les systemes superfluides: contributions de la structure nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Khan, E

    2005-12-15

    The author presents successively the theoretical aspect, the experimental aspect and the applied aspect of excitations in nuclear structures. The quasi-particle random phase approximation (QRPA) tool is first described. Recent approaches on QRPA are based on the theory of the density function where the ground state and excited states are described from the same nucleon-nucleon interaction. 2 methods for measuring the collective excitations are then presented: the proton scattering that has the potentiality to investigate the evolution of magicity, the second method is in fact a new method for measuring the giant mono-polar resonance (GMP) in exotic nuclei. Nuclear reactions are considered as a compulsory step on the way from observables like cross-sections to nuclear structure. The author highlights the assets of the convolution model that can generate the optical potential from the effective nucleon-nucleon interaction and from proton and neutron densities of the nuclei involved. R-processes in nucleosynthesis and neutron stars are reviewed as applications of collective excitations in the field of nuclear astrophysics. (A.C.)

  9. Cold-crucible fabrication of nuclear glasses; L'elaboration de verres nucleaires en creuset froid

    Energy Technology Data Exchange (ETDEWEB)

    Boen, R. [Division de l' energie nucleaire, CEA Centre de Valrho-Marcoule (France)

    2010-07-01

    Vitrification has stood the nuclear industry in good stead, for many years now, as a safe long-term conditioning technology for high-level waste. Major advances are nonetheless still being made, with the development of the cold-crucible technology, affording as it does new possibilities, in terms of volume reduction, and of extending the range of waste products amenable to incorporation. Indeed, by allowing higher melting temperatures to be achieved (1200 - 1400 C degrees), this process opens the way to a considerable increase in glass production capacities, and the fabrication of novel matrices, involving higher incorporation rates than current glasses. In the cold-crucible technology, materials put into the crucible are heated directly through induction. The crucible made of metal is cooled by water circulation. Where the glass comes into contact with the cold wall, a thin layer of solidified glass forms, with a thickness of 5-10 mm preventing the metal forming the crucible from coming into contact with the molten glass. A full scale pilot of the cold crucible was constructed at the La Hague vitrification workshop

  10. Can world answer the new nuclear necessity?; Le monde peut-il repondre a la nouvelle necessite du nucleaire?

    Energy Technology Data Exchange (ETDEWEB)

    Finon, D

    2003-09-01

    Thanks to climatic change policies and to the prospective studies about the depletion of oil and gas reserves, a new chance will be given to nuclear energy. However, even if the nuclear industry has become more transparent, more attentive to the public preoccupations, and permanently looking for a demonstration of its safety, the institutional bases of its re-start up (the participating decision processes and the competing framework of electric markets) are much less favourable than those of its initial technological development. The future of nuclear energy is not warranted except if a strong consensus happens in dominating countries about the real or assumed catastrophic consequences of the greenhouse effect and if this sudden awareness changes the public opinion about the specific risks of nuclear energy and radioactive wastes. The uncertainty which will remain during, at least, the next 15 years will greatly complicate the choices of the nuclear industry and of the governments. For this reason, a paradoxical effort has to be made for the promotion of energy efficiency and renewable energy sources. (J.S.)

  11. Has the nuclear energy a future?; L'energie nucleaire a-t-elle un avenir?

    Energy Technology Data Exchange (ETDEWEB)

    Nifenecker, H

    2005-07-01

    The author wonders on the nuclear energy opportunity for the future and concludes on the possibility of the nuclear park replacement after 2030 by breeder reactors. Such a choice will allow to face the energy demand in good economical and environmental conditions. The main problem seems to be the public opinion, not in favor of a nuclear energy. (A.L.B.)

  12. Activities report for 1993-1994; Centre de Recherches Nucleaires Strasbourg - Rapport d`activite 1993-1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    The period of 1993 1994 has seen the first experiences of the Vivitron and the multi detector E.U.R.O.G.R.A.M.They concern study of properties of superdeformed nuclei. The CRN is invested on the way of an other priority project for the decade to come: the preparation of experience near the future L.H.C collider at C.E.R.N.. Different contributions to researches, developments for detectors are explained. (N.C.).

  13. France, Germany and the nuclear challenge; La France, l'Allemagne et l'enjeu nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Turkish, F

    2004-11-15

    Taking into account the french and german relations concerning the nuclear activities, the nuclear phaseout decided by the german government in 1998 presents inevitable impacts in France. The author discusses the constraints bound to this project (industrial interests, energy dependence...), the short dated phaseout project and the consequences for the relations of the two countries, Germany and France. (A.L.B.)

  14. Nuclear power plant of Fessenheim: evaluation of the seismic risk; Centrale Nucleaire de Fessenheim: appreciation du risque sismique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The seismic risk taken into account during the sizing of the nuclear power plant of Fessenheim seems to have been under evaluated at this time. The revaluation of the seismic risk, as proposed, until this day by EDF in order to the third ten-year visit of the power plant, planned for 2009, leads to a significant under evaluation of the risk and then is not acceptable. The present expertise details point by point the weaknesses of these revaluation. The power plant has been sized in an elastic manner that is generally strongly for the safety side. It is imperative to proceed the most quickly as possible to a deep control of the seismic resistance of the power plant of Fessenheim and then after having proceeded to a revision of the seismic risk in taking into account the actual knowledge in this field. (N.C.)

  15. Assessment of environment survey (2005-2009). Synthesis of results and comments - 'ACROnic du nucleaire' nr 91, December 2010

    International Nuclear Information System (INIS)

    2010-12-01

    This document presents and comments radioactivity level measurements performed by the Citizen Observatory of radioactivity in the environment which has been created by the ACRO (Association for the Control of Radioactivity in the West). As several nuclear installations are present in this part of France (power station, reprocessing plants, waste storage centre, military harbour), measurements have been made during five years (2005-2009) along the coasts of Normandy and in some waterways and lands. Several topics are addressed: marine environment (radioactivity measurements in species and algae), sediments on the coast (cobalt 60, americium-241, caesium-137), sea water (tritium activity), radiological status of brooks around La Hague (detection of 5 isotopes: cobalt 60, americium-241, caesium-137, iodine-129 and ruthenium-rhodium-106). A focus is made on tritium

  16. IAEA: 17 countries are candidates for nuclear energy; AIEA: 17 pays candidats a l'energie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2011-01-15

    In january 2011 IAEA announced that 17 countries had officially expressed their willingness to home nuclear power plants, they have filed applications for the construction of nuclear power plants. Among the countries concerned we find: Poland, Kuwait, Jordan, Morocco, Tunisia, Nigeria, Bangladesh, Thailand, Vietnam, Chile and Uruguay

  17. Modelling of heterogenous neutron leakages in a nuclear reactor; Modelisation des fuites heterogenes de neutrons dans un reacteur nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Wohleber, X

    1997-11-17

    The TIBERE Model is a neutron leakage method based on B{sub 1} heterogeneous transport equation resolution. In this work, we have studied the influence of the reflection mode at the boundary of the assembly. In particular the White boundary condition has been implemented in the APOLLO2 neutron transport code. We have compared the two TIBERE kinds of boundary conditions (specular and white) with the classical B{sub 1} homogeneous leakage method in the modelling of some reactors. We have remarked the better capability of the TIBERE Model to compute voided assemblies. The white boundary condition is also able to compute a completely voided assembly and, besides, wins a factor 10 in CPU time in comparison with the specular boundary condition. These two heterogenous leakage formalisms have been tested on a partially voided experiment and have shown that the TIBERE Model can compute this kind of situation with a greater precision than the classical B{sub 1} homogeneous leakage method, and with a shorter computational time. (author)

  18. Circumstances and consequences of Oural nuclear plant spoils; Circonstances et consequences des rejets des installations nucleaires de l`Oural

    Energy Technology Data Exchange (ETDEWEB)

    Nenot, J.C.

    1994-12-31

    The environment pollution frames serious long-dated problem. The civil nuclear power unhappily does not rest. The liquid waste fuel cycle plant prospective, particularly at their working beginning. 14 refs., 5 tabs.

  19. The nuclear industry: a new weapon for the Kremlin?; L'industrie nucleaire: nouvelle arme du Kremlin?

    Energy Technology Data Exchange (ETDEWEB)

    Du Castel, V.

    2010-07-01

    After having noticed the recent evolution of the Russian policy which tends to concentrate the economical and political power with a limited democratic pluralism, the author describes the re-structuring policy adopted for the energy sector, and notably the nuclear sector, in order to become a major international actor. First, she analyses the evolution of the hydrocarbon sector with a better management of tax incomes, and a stronger control of the industries of this sector based on a State capitalism development. She outlines that Russia now uses energy as a diplomatic arm, particularly in its relationship with the European Union. She states that Russia may want to follow the same kind of policy for nuclear energy as for the hydrocarbon sector by developing partnership with other countries, by regrouping the concerned activities within a single holding company (Atomenergoprom) and a federal agency (Rosatom). Russia increased its uranium production and became a powerful actor who challenges other international companies (Areva, Westinghouse, Toshiba). The author discusses the strategy defined by the Kremlin to reach supremacy in the nuclear sector

  20. Thermodynamical modeling of nuclear glasses: coexistence of amorphous phases; Modelisation thermodynamique des verres nucleaires: coexistence entre phases amorphes

    Energy Technology Data Exchange (ETDEWEB)

    Adjanor, G

    2007-11-15

    Investigating the stability of borosilicate glasses used in the nuclear industry with respect to phase separation requires to estimate the Gibbs free energies of the various phases appearing in the material. In simulation, using current computational resources, a direct state-sampling of a glassy system with respect to its ensemble statistics is not ergodic and the estimated ensemble averages are not reliable. Our approach consists in generating, at a given cooling rate, a series of quenches, or paths connecting states of the liquid to states of the glass, and then in taking into account the probability to generate the paths leading to the different glassy states in ensembles averages. In this way, we introduce a path ensemble formalism and calculate a Landau free energy associated to a glassy meta-basin. This method was validated by accurately mapping the free energy landscape of a 38-atom glassy cluster. We then applied this approach to the calculation of the Gibbs free energies of binary amorphous Lennard-Jones alloys, and checked the correlation between the observed tendencies to order or to phase separate and the computed Gibbs free energies. We finally computed the driving force to phase separation in a simplified three-oxide nuclear glass modeled by a Born-Mayer-Huggins potential that includes a three-body term, and we compared the estimated quantities to the available experimental data. (author)

  1. Influence of nuclear glasses composition on their liability to deterioration; Influence de la composition des verres nucleaires sur leur alterabilite

    Energy Technology Data Exchange (ETDEWEB)

    Tovena, I.

    1995-09-29

    This contributes to the study of the nuclear glasses composition influence on their liability to deterioration. The methodology of the experimental research used has lead to define between the thirty oxides which form the reference glass light water, six oxides of interest. For each of these oxides, a composition variation area has been defined. A matrix of twenty glass compositions has then been defined. The preparation of materials of these compositions has sometimes lead to materials weakly heterogeneous which have been characterized before deterioration. This study has been completed by those of three glasses in a composition variation area narrower of the light water nuclear glass : the R7T7 and two glasses at limits having respectively an initial dissolution velocity at 100 degrees Celsius theoretically maximum and minimum. Some deterioration parameters in pure water have been experimentally measured on the twenty three glasses : 1) an initial dissolution velocity at 100 degrees (Vo{sub 1}00) Celsius and another one at 90 degrees Celsius (Vo{sub 9}0) 2) a dissolution velocity in conditions near the saturation at 90 degrees Celsius 3) an apparent solubility of glass based on the ortho silicic acid activity 4) the evolution of the dissolution kinetics at 90 degrees Celsius in sub-saturated medium towards saturated medium 5) the alteration films nature developed at the glasses surface during these last alteration tests. Some thermodynamic and structural models have been studied in order to predict Vo{sub 9}0 and Vo{sub 1}00. The dissolution kinetic law developed from reference glass dissolution results has been studied with the calculation code LIXIVER. It has not been able to be used for most of the glasses compositions studied. As a consequence, the glasses dissolution control by a surface reaction which are itself controlled by the only dissolved silica is an hypothesis which is not verified for the greater part of the glasses. (O.L.). refs., figs., tabs.

  2. Nuclear Energy, a way for tomorrow spacecrafts; L'energie nucleaire, une voie pour les vaisseaux spatiaux de demain

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    To better explore the solar system, the NASA will uses new propulsion modes, in particular the nuclear energy. These articles present the research programs in the domain and the particularities of the nuclear energy in the projects. (A.L.B.)

  3. New parameterizations of the Gogny effective nuclear interaction; Nouvelles parametrisations de l'interaction nucleaire effective de Gogny

    Energy Technology Data Exchange (ETDEWEB)

    Chappert, F

    2007-06-15

    The effective interaction between nucleons is the basic input to microscopic calculations in nuclear structure. One of the forms used since the 1970's is the phenomenological effective force proposed by D. Gogny. This force gives excellent results in nuclei at the mean-field approximation. The presence of contact terms does not allow, however, to use it for the description of beyond mean-field correlations present in nuclei. In this work, we investigate some extensions of the Gogny force, and especially a generalization in which the zero range density dependent term has been replaced by a finite range term. The parameters occurring in the analytical form of the force have been adjusted on symmetric infinite nuclear matter and neutron matter properties, and on some selected observables for stable nuclei, especially those related to pairing correlations. We present the method to include this kind of force in Hartree-Fock-Bogoliubov calculations and we analyze the results obtained for various nuclei. The new versions of the Gogny force allow us to reproduce nuclear structure properties with improved accuracy as compared to the former version. (author)

  4. MEDECINE NUCLEAIRE ET MALADIE CORONARIENNE : EVALUATION DE TRACEURS DE LA PERFUSION MYOCARDIQUE ET DE LA PLAQUE D'ATHEROME VULNERABLE

    OpenAIRE

    Broisat, Alexis

    2005-01-01

    CORONARY ARTERY DISEASE IS ONE OF THE PRIMARY CAUSE OF MORTALITY WORLDWIDE. NUCLEAR MEDICINE IS THE MAJOR IMAGING TECHNIQUE FOR DIAGNOSIS AND FOLLOWING OF THIS DISEASE. PERFUSION : NOWADAYS, MAJOR RADIOACTIVE AGENTS USED IN CLINICAL PRACTICE ARE MYOCARDIAL PERFUSION TRACERS. THE REFERENCE TRACER IS THALLIUM-201. HOWEVER, 201TL PRESENTS SOME DRAWBACKS. 99MTCN-NOET HAS BEEN PROPOSED FOR ITS REPLACEMENT. THIS STUDY SHOWS THAT IN CONTRAST WITH PREVIOUS STUDIES REALIZED IN VITRO ON CARDIOMYOCYTES,...

  5. Behaviour norms for nuclear energy peaceful uses; Code de bonne conduite pour les utilisations pacifiques de l`energie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Strohl, P. [Nuclear Energy Agency, 75 - Paris (France)

    1996-10-01

    After making a brief history on the nuclear law, the author shows that ethical aspects got involved in nuclear matters at three levels: security of nuclear supplies, radioactive waste management, and potential human failures. Then a list of ``good conduct norms`` which should be the link between law and ethics is given. They correspond to different issues of nuclear development: technological quality, radiation protection, radioactive waste management, public information, international cooperation, non-proliferation. (TEC).

  6. Some aspects of the algerian nuclear activities regulations; Quelques aspects de la reglementation algerienne des activites nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Cherf, A.

    1996-10-01

    This document explains the necessity of the creation of an atomic energy agency in Algeria. Its first role was to enhance nuclear activities, but in the same time to take care of radiological risks. But nowadays its main mission is to improve regulations in radiation protection with research and development studies and technical assistance. (TEC).

  7. IAEA and the international nuclear law development; L`A.I.E.A. et le developpement du droit nucleaire international

    Energy Technology Data Exchange (ETDEWEB)

    Jankowitsh, O. [International Atomic Energy Agency, Vienna (Austria)

    1996-10-01

    This paper summarizes the different objectives of the IAEA (International Atomic Energy Agency) as far as nuclear energy use is concerned. It presents the status of the organization, its action int the non-proliferation treaty, and its work on the safeguard regulations. These measures have been taken during the Convention on nuclear safety in 1994. This convention concerns nuclear power plants as well as storage of radioactive wastes. (TEC).

  8. Nuclear civil liability international system. Evolution prospects.; Le regime international de responsabilite civile nucleaire. Perspectives d`evolution

    Energy Technology Data Exchange (ETDEWEB)

    Reyners, P. [Nuclear Energy Agency, 75 - Paris (France)

    1996-10-01

    This paper sets out the necessity of a special system of international conventions in the scope of nuclear civil liability. Then the main principles of the conventions in Paris and Vienna are described. Recently, works have been carried out in order to improve and modernize the civil liability system. (TEC). 4 tabs.

  9. Medical surveillance of outside workers in base nuclear facilities; Surveillance medicale des travailleurs exterieurs dans les installations nucleaires de base

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1997-06-01

    Here are described two bylaws relative to the training of doctors in charge of the radiation protection of outside enterprises workers and susceptible to intervene in nuclear facilities, and to the entitlement clauses of medical services in charge to make the medical surveillance of outside enterprises workers intervening in nuclear facilities. (N.C.).

  10. Propagation of neutrinos in nuclear matter; Effets du milieu sur la propagation des neutrinos dans la matiere nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Margueron, J

    2001-07-01

    We study the elementary interactions between neutrinos and dense matter in a proto-neutron star. Equations of state obtained with different nuclear effective interactions (Skyrme, Gogny, Relativistic Lagrangians) are first discussed. Then, we characterize their stability in spin and isospin. We derive magnetic susceptibilities for all isospin asymmetry values as a function of Landau parameters G{sup {pi}}{sup {pi}}{sup '}{sub 0} (where {pi}, {pi}' = proton or neutron). From this work, we select a parametrization for each of the 3 effective forces: Sly230b,D1P,NL3. We calculate the pure neutron matter and asymmetric nuclear matter response functions with and without charge exchange, describing nuclear correlations in both approaches: non-relativistic (Hartree-Fock with Skyrme forces, then complete RPA) and relativistic (in the Hartree approximation). At the end, we calculate neutrino mean free paths neutral current and charged current reactions. Comparisons between relativistic and non-relativistic approaches allow us to identify relativistic effects in nuclear matter at densities as low as twice the saturation density. RPA correlations make the medium more transparent to neutrinos compared to free Fermi gas. The importance of the effective mass in mean free path calculations is also shown. (author)

  11. The Iranian nuclear programme-an equation with many unknowns; Le programme nucleaire iranien, une equation aux multiple inconnues

    Energy Technology Data Exchange (ETDEWEB)

    Hamel, T. [Universite Robert Schuman, 67 - Strasbourg (France)

    2007-07-15

    So, is Iran a threat or a victim? Although it has no previous history of aggression, Iran continues to disturb the international community with its nuclear programme, while declaring that it is under threat from its neighbours and the victim of propaganda. Yet why does a country with such large reserves of oil and gas need a nuclear industry? This question arose as long ago as the early 1970, and it arises again today. The Shah was a Gaullist, Khomenei a Gaullist ayatollah, and today it is not the Ayatollah but the Gaullist posture that is the more disturbing. A Blairite ayatollah will surely suit Washington nicely. (author)

  12. Those nuclear wastes nobody knows what to do with; Ces dechets nucleaires dont on ne sait que faire

    Energy Technology Data Exchange (ETDEWEB)

    Boilley, D

    1998-01-01

    The important use of nuclear energy in Europe, and in particular in France, has a beneficial impact on the air quality but raises important problems of radioactive waste management. The technical problems encountered by the French government with the dismantling of Superphenix reactor are a good example. Moreover, despite its reassuring talks, the electronuclear industry lobby, particularly powerful, has never been able to propose any satisfactory solution for the elimination of radioactive wastes. This article makes a criticism of the lack of visibility and democratic debate in France about the sensible subject of nuclear waste management. A comparison with the situation in other countries is made. (J.S.)

  13. Remote-operated systems for interventions in civil nuclear facilities; Systemes teleoperes pour interventions dans les installations nucleaires civiles

    Energy Technology Data Exchange (ETDEWEB)

    Bonneville, A. [Groupe INTRA, 37 - Avoine (France)

    1999-10-01

    This short paper is a presentation of the aerial and terrestrial means developed by the Intra Group specialized in interventions in the case of nuclear accidents and incidents. The aerial means consist in a airborne system called Helinuc and which can perform spectro-gamma measurements over surfaces of about 15 km{sup 2} using an `Ecureuil`-type helicopter. The terrestrial means comprise different types of robots for surveys, sampling, manipulation, various works etc.. and remote-controlled caterpillar tractors, shovels and dumper trucks. (J.S.)

  14. Nuclear cardiology in Senegal: a luxury or a need?; Cardiologie nucleaire au Senegal: un luxe ou une necessite

    Energy Technology Data Exchange (ETDEWEB)

    Mbodj, M.; Seck Gassama, S.; Ndong, B.; Ndoye, O.; Toure Sow, H.; Senghor, S.R. [Universite Cheikh Anta Diop, Lab. Biophysique et Service de Medecine Nucleaire, Faculte de Medecine, de Pharmacie et d' Odontostomatologie, Dakar (UCAD) (Senegal); Diop, S.N. [Centre Antidiabetique Marc Sankale, Hopital Abass Ndao, Dakar (Senegal); Solanki, K.K. [International Atomic Energy Agency, Dept. de la Cooperation Technique, Section Medecine Nucleaire, Vienna (Austria)

    2006-06-15

    Aim: to sensitize at the same time experts and public authorities on the interest of the establishment of nuclear cardiology in Senegal. Material and method: the radioimmunoassay of micro-albuminuria, early marker of cardiovascular morbid-mortality was carried out in the nuclear medicine department of Dakar on a population of 100 diabetic patients (74 of type 1 and 26 of type 2) presenting one or more traditional cardiovascular risk factors. Out of these patients, 39% had abnormal rest ECG, asymptomatic in half of the cases. Results: prevalence of micro-albuminuria is high (24%). There is no significant difference in distribution between type I and type 2. Micro-albuminuria > 30 mg/24 h exists in 16,3% of patients with lipid abnormalities (ratio: total cholesterol/HDL cholesterol > 5), 30% of obese, 75% of hypertensive patients and 43,6% of patients with abnormal rest ECG, who would benefit from myocardial perfusion imaging (MPI): about 17% of patients involved in this study. No or weak correlation is found between micro-albuminuria and traditional risk factors. Conclusion: From these results and available epidemiological data in 2005, the estimate of the requirements in nuclear cardiology for the Senegalese diabetic population, indicates that 3740 patients should have benefited that year from it. Considering that this figure underestimates the real needs, taking into account the needs brought back to a population of 10 million inhabitants and the expect expansion of the diabetic disease, it appears justified to include the nuclear cardiology in the national programmes of prevention of the public health in Senegal. (author)

  15. Nuclear dismantling and asbestos elimination: the same challenge?; Demantelement nucleaire et elimination d'asbeste: un meme challenge?

    Energy Technology Data Exchange (ETDEWEB)

    Dadoumont, J.; Deboodt, P. [Centre d' Etude de l' Energie Nucleaire, Mol (Belgium)

    1998-07-01

    The ALARA principle constitutes a powerful tool for workers dosimetry management in the nuclear field. A consequence of the application of this principle could be an accentuation of the nuclear risk face to the industrial risk. Using works of asbestos elimination in nuclear medium, the present article examines how a generalization of the utilization of the ALARA principle is conceivable and how the existing obstacles could be removed. (N.C.)

  16. 15 years after Chernobyl. Nuclear plus greenhouse effect?; 15 ans apres Tchernobyl. Nucleaire plus effet de serre?

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, M. [Wise-Paris, 75 (France); Rosen, M. [International Atomic Energy Agency (IAEA), Vienna (Austria)

    2001-04-15

    Today, the argument in favour of nuclear energy is not an economical one nor linked to energy resources but is at the level of climatic change. Nuclear energy is seen as the only energy source without carbon dioxide emissions. A more detailed analysis of greenhouse gases on the life cycle shows that nuclear energy gives as greenhouse gases as big hydroelectric power plants or wind power plants, these emissions are more important than for biogas installations with cogeneration. The strategy of energy efficiency is certainly more competitive than the new reactors in other terms it is more efficiency to reduce the consumption than to increase the nuclear production. (N.C.)

  17. Facing the climatic threat, the nuclear illusion; Face a la menace climatique, l'illusion du nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    In the framework of the energy problem, the network Action Climate brings many propositions to explain that the nuclear is not a solution to the global warming. A boost to the nuclear will be done to the detriment of cheaper, safer and more adapted policies, as the energy conservation and efficiency, the energy production decentralization and the renewable energies development. The three parts shows how the nuclear cannot answer to the climatic problem, the nuclear refutes the Rio declaration on the environment and the sustainable development, the nuclear is a french specificity which damages the national policy against the climatic change. (A.L.B.)

  18. Medical intervention in case of nuclear or radiation event; Intervention medicale en cas d'evenement nucleaire ou radiologique

    Energy Technology Data Exchange (ETDEWEB)

    Blanc, J.; Bourguignon, M.; Carli, P.; Carosella, E.; Challeton de Vathaire, C.; Court, L.; Ducousso, R.; Facon, A.; Fleutot, J.B.; Goldstein, P.; Gourmelon, P.; Herbelet, G.; Kolodie, H.; Lallemand, J.; Martin, J.C.; Menthonnex, P.; Masse, R.; Origny, S.; Pasnon, J.; Peton Klein, D.; Rougy, C.; Schoulz, D.; Romet, G.; Telion, C.; Vrousos, C

    2002-07-01

    This guide aims to be a practical tool for intervenors in case of nuclear or radiation accident. It proposes many sheets to favor the reactivity and the implementing of adapted measures. It concerns the course of action to take in case of irradiation accident or contamination and the reception in medical structure or a hospital. (A.L.B.)

  19. Exotic nuclei: another aspect of nuclear structure; Les noyaux exotiques: un autre regard sur la structure nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Dobaczewski, J. [Warsaw Univ., Institute of Theoretical Physics (Poland); Blumenfeld, Y.; Flocard, H.; Garcia Borge, M.J.; Nowacki, F.; Rombouts, S.; Theisen, Ch.; Marques, F.M.; Lacroix, D.; Dessagne, P.; Gaeggeler, H

    2002-07-01

    This document gathers the lectures made at the Joliot Curie international summer school in 2002 whose theme that year was exotic nuclei. There were 11 contributions whose titles are: 1) interactions, symmetry breaking and effective fields from quarks to nuclei; 2) status and perspectives for the study of exotic nuclei: experimental aspects; 3) the pairing interaction and the N = Z nuclei; 4) borders of stability region and exotic decays; 5) shell structure of nuclei: from stability to decay; 6) variational approach of system with a few nucleons; 7) from heavy to super-heavy nuclei; 8) halos, molecules and multi-neutrons; 9) macroscopic approaches for fusion reactions; 10) beta decay: a tool for spectroscopy; 11) the gas phase chemistry of super-heavy elements.

  20. The bomb black market - Inquiry about nuclear proliferation; Le marche noir de la bombe - Enquete sur la proliferation nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Tertrais, B

    2009-07-01

    Nuclear weapons remain for a long time in the hands of the five big powers: USA, Soviet Union, Great Britain, France and China. Things started to change when Israel, and then India acquired the atomic bomb as well. Pakistan took up the race too but Abdul Qadeer Khan, one of the nuclear program maker of the country, took profit of the situation to set up a huge international proliferation network for the spreading of the technologies, tools and materials necessary for weapons fabrication. He offered his services not only to Iran and North Korea, but to Iraq and Libya as well and probably to some other countries. Today, the Iranian nuclear program generates both envy and fear in the Middle East. Who is going to be the next domino of the nuclear game? Egypt, Saudi Arabia, Algeria and Turkey are potential candidates. But while Pakistan sinks into crisis, the terrorists are taking interest in nukes. The author of this book has worked for more than 10 years on this dossier. He has had access to the most sensible documents and to essential testimonies. He now lifts the curtain on the secrets of nuclear proliferation. In this book, where reality sometimes surpasses fiction, he explains how the CIA finally succeeded in infiltrating the 'Khan ring' after having closed its eyes on his deals for a long time. He describes the branches of the Pakistani atomic complex and analyses with lucidity the nuclear terrorism risk.

  1. Desalination of seawater: a nuclear solution; Dessalement de l'eau de mer: la solution nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Basta, H

    2003-04-01

    1,4 milliard human beings do not benefit of sufficient clean water supply. The desalting of seawater is a valid and tested solution in terms of technology but the 2 physical processes involved, evaporation and reverse osmosis are energy-greedy. Only rich countries like Kuwait or Saudi-Arabia can afford producing massive volumes of fresh water from seawater. Today the total world capacity of desalting reaches 30 milliard m{sup 3} a day with 10.000 operating units, half of which installed in middle-east countries. The use of nuclear energy is a solution to lower costs. In Aktau (Kazakhstan) a BN-350 fast reactor has been producing a 135 MW electrical output and 80.000 m{sup 3} of fresh water a day for 27 years. In Japan about 10 desalting units have been coupled to nuclear power plants. A company (Eskom) based in South-Africa is developing a new concept of high temperature reactor: the PBMR (pebble bed modular reactor). The suitability of this reactor has been assessed for desalting and it appears that its main assets are its size: 165 MW electrical output (400 MW thermal output) and its Brayton cycle. Other characteristics such as the coolant (helium), the type of fuel (8% enriched uranium encapsulated in carbon), the low design and maintenance costs, the short building time (2 years) are important when considering issues like nuclear safety, non-proliferation and profitability. (A.C.)

  2. Desalination of seawater with nuclear reactors; Le dessalement de l'eau de mer pour les reacteurs nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Nisan, S.; Volpi, L. [CEA Cadarache, Dir. du Developpement et de l' Innovation Nucleares-DDIN, 13 - Saint-Paul-lez-Durance (France)

    2001-12-01

    About 40 % of the world population is concerned with water scarcity. This article reviews the different techniques of desalination: distillation (MED and MSF), reverse osmosis (RO), and electrodialysis (ED). The use of nuclear energy rests on several arguments: 1) it is economically efficient compared to fossil energy; 2) nuclear reactors provide heat covering a broad range of temperature, which allows the implementation of all the desalination techniques; 3) the heat normally lost at the heat sink could be used for desalination; and 4) nuclear is respectful of the environment. The feedback experience concerning nuclear desalination is estimated to about 100 reactor-years, it is sufficient to allow the understanding of all the physical and technological processes involved. In Japan, 8 PWR-type reactors are coupled to MED, MSF, and RO desalination techniques, the water produced is used locally mainly for feeding steam generators. (A.C.)

  3. Automatic classification process and device for nuclear fuel pellets; Procede et dispositif de tri automatique de pastilles de combustible nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Bernardin, M.; Bouvet, P.; Wache, C.

    1994-07-01

    The device arranges the fuel pellets in several parallel files. The end pellet of each file are then removed and aligned. These pellets are then simultaneously transferred on an optical inspection arrangement and are turned simultaneously for examination. The light signal is analysed to determine if each pellet is correct, acceptable or reject. The pellets are then held by individual grabs which displace to a separation system where the individual grabs are controlled to open in response to the result of the signal analysis. 13 figs.

  4. Status of safety at Areva group facilities. 2006 annual report; Etat de surete des installations nucleaires. Rapport annuel 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This report presents a snapshot of nuclear safety and radiation protection conditions in the AREVA group's nuclear installations in France and abroad, as well as of radiation protection aspects in service activities, as identified over the course of the annual inspections and analyses program carried out by the General Inspectorate in 2006. This report is presented to the AREVA Supervisory Board, communicated to the labor representation bodies concerned, and made public. In light of the inspections, appraisals and coordination missions it has performed, the General Inspectorate considers that the nuclear safety level of the AREVA group's nuclear installations is satisfactory. It particularly noted positive changes on numerous sites and efforts in the field of continuous improvement that have helped to strengthen nuclear safety. This has been possible through the full involvement of management teams, an improvement effort initiated by upper management, actions to increase personnel awareness of nuclear safety culture, and supervisors' heightened presence around operators. However, the occurrence of certain events in facilities has led us to question the nuclear safety repercussions that the changes to activities or organization on some sites have had. In these times of change, drifts in nuclear safety culture have been identified. The General Inspectorate considers that a preliminary analysis of the human and organizational factors of these changes, sized to match the impact the change has on nuclear safety, should be made to ensure that a guaranteed level of nuclear safety is maintained (allowance for changes to references, availability of the necessary skills, resources of the operating and support structures, etc.). Preparations should also be made to monitor the changes and spot any telltale signs of drift in the application phase. Managers should be extra vigilant and the occurrence of any drift should be systematically dealt with ahead of implementing corrective actions. The level 2 INES event that occurred in the ATPu facility in Cadarache was therefore considered particularly significant by the General Inspectorate. The activities being carried out within the entity at the time of the event were singular and the identified causes numerous, but were fundamentally the product of human and organizational factors. The lessons learnt from this event need to be shared with all other entities. Like many other less significant events that took place in 2005 and 2006, this event led the General Inspectorate to focus particularly on criticality risk control on sites where fissile material is used. It considers that internal criticality control actions must be carried out on these sites in order to make sure the required provisions are known and applied by all operators. In-service fire risk control hinges on - among other things - the application of fire prevention, protection and preparation rules, which must be a constant concern of site managers. The General Inspectorate noted numerous positive developments on most sites in this field in 2006, as well as the production entities' full cooperation with the risk analysis services and fire-fighting services. On most sites, fire risk control is organized clearly and in a structured manner.

  5. Status of safety at Areva group facilities. 2007 annual report; Areva, etat de surete des installations nucleaires. Rapport annuel 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report describes the status of nuclear safety and radiation protection in the facilities of the AREVA group and gives information on radiation protection in the service operations, as observed through the inspection programs and analyses carried out by the General Inspectorate in 2007. Having been submitted to the group's Supervisory Board, this report is sent to the bodies representing the personnel. Content: 1 - A look back at 2007 by the AREVA General Inspector: Visible progress in 2007, Implementation of the Nuclear Safety Charter, Notable events; 2 - Status of nuclear safety and radiation protection in the nuclear facilities and service operations: Personnel radiation protection, Event tracking, Service operations, Criticality control, Radioactive waste and effluent management; 3 - Performance improvement actions; 4 - Description of the General Inspectorate; 5 - Glossary.

  6. The struggle of the veterans of the French nuclear tests; La lutte des veterans des essais nucleaires francais

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    The question debated in this article concerns the demand of compensation and recognition of the impact on their health of nuclear tests. The military personnel that worked during nuclear tests in French Polynesia and the Sahara sites, but also the inhabitants of the atolls of Moruroa and Fangataufa equally in French Polynesia. An observatory of the veterans health has been created in order to improve the medical management of military personnel and former military personnel. An association 'Moruroa e tatou' contains the Polynesian former workers of the Nuclear tests of the Pacific and the association A.V.E.N. contains the veterans of nuclear tests. numerous examples are detailed. The question is tackled too for the consequences on health of the British nuclear tests, in Australia, Christmas Islands, and New Zealand. (N.C.)

  7. The myeloid splenomegaly in a service of nuclear medicine; La splenomegalie myeloide dans un service de Medecine Nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Rain, J-D.; Najean, Y.; Billoty, C. [Service de Medecine Nucleaire, Hopital Saint-Louis, Paris (France)

    1997-12-31

    The existence in a Nuclear Medicine service of several in-vivo (scintigraphy and kinetic) and in-vitro (dosages) sections can contribute into a better knowledge of diseases due to the complementarity of the provided information. Exploration, since 1990, of 183 primary and secondary myeloid splenomegalies (MS) is a good example. These 183 patients have had a medullary scintigraphy with Technetium colloids and Indium Transferrin, 98, a measurement of the sanguine mass, 60, a kinetic study of Iron-Chromium erythropoiesis and 180, a dosage of pro-collagen III. These four examinations allowed confirming the MS diagnosis and orienting the prognostic. The medullary scintigraphy is able to show the poverty of marrow-sustaining tissues and allows measuring the splenomegaly. It helps evaluating the wealth of myelopoietic tissue and its extensions and confirming the spleenic erythropoiesis. The measure of sanguine mass specifies the existence and importance of true anaemia and hemodilution due to the splenomegaly. The kinetic study by Iron-Chromium indicates the medullary spleenic production, degree of dys-erythropoiesis, the presence of hemolysis and its location. It brings about important prognostic arguments and is a precious aid in making the difficult decision of indication of splenectomy. The pro-collagen III dosage is of a certain prognostic interest. The patients with less than 0.70 U/ml have a slow evolutivity of their disease, those with values within 0.70 to 1 U/ml have a more severe evolution, while for those having values higher than 1 U/ml the prognostic is bad on short terms. In conclusion, the diagnosis and prognostic of these examinations in MS justify maintenance of a plurality of in-vivo and in-vitro techniques in our services

  8. The behaviour of some polyatomic gases in nuclear reactors; Le comportement de quelques gaz polyatomiques dans les reacteurs nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Dolle, L. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    The chemical effect of ionizing radiations on a certain number of gaseous systems is described. Under the influence of radiations from a reactor, NH{sub 3}, is decomposed to nitrogen and hydrogen in stoichiometric proportions. Formation of N{sub 2}H{sub 3}, particularly could not be detected. Under a slow neutron flux the reaction {sup 14}N (n, p) {sup 14}C constitutes the main source of decomposition energy. Direct recombination of H, and N, has been brought about under the influence of radiation. The radiolysis of NH{sub 3}, occurs by a complex mechanism; and the kinetics follow a law of the order of about 2.5 which increases with the decomposition rate. The decomposition of hydrogen sulphide is appreciably faster than that of NH{sub 3}. Hydrogen is the only gaseous product of the reaction. The sulphur, which is deposited on the walls of the ampoules, is clearly visible to the naked eye. Up to the present decompositions up to 84 per cent have been obtained. The influence of the reaction {sup 32}S (n, p) {sup 32}P is considered. Radiochemical decomposition of nitrous oxide N{sub 2}O takes place with high yields. The reaction is complicated from the beginning by the formation of higher oxides of nitrogen which we identify and measure. Radiochemical decomposition of methane gives quantities of higher hydrocarbons. Certain of these gaseous systems could find applications in the measurement of high doses of radiation. This problem is discussed in the conclusion. (author)Fren. [French] L'effet chimique des rayonnements ionisants sur un certain nombre de systemes gazeux est decrit. Sous l'influence des rayonnements d'un reacteur, NH{sub 3} se decompose en azote et hydrogene en proportions stoechiometriques. En particulier aucune formation de N{sub 2}H{sub 4}, n'a pu etre detectee. Sous flux de neutrons lents, la reaction {sup 14}N (n, p){sup 14}C constitue la principale source d'energie de decomposition. La recombinaison directe de H{sub 2} et N{sub 2} a ete realisous l'influence des radiations. La radiolyse de NH{sub 3}, procede par un mecanisme complexe, et la cinetique obeit a une loi d'ordre 2,5 environ qui augmente avec le taux de decomposition. La decomposition de l'hydrogene sulfure est notablement plus rapide que celle de NH{sub 3}. Le seul produit gazeux de la reaction est l'hydrogene. Le soufre, qui se depose sur les parois des ampoules, est nettement perceptible a l'oeil. On a obtenu jusqu'ici des decompositions allant jusqu'a 84 pour cent. L'influence de la reaction {sup 32}S (n, p) {sup 32}P est consideree. La decomposition radiochimique du protoxyde d'azote N{sub 2}O se fait avec des rendements eleves. La reaction est compliquee des ses debuts par la formation d'oxydes superieurs de l'azote que nous identifions et mesurons. Le methane donne par decomposition radiochimique des quantites d'hydrocarbures superieurs. Certains de ces systemes gazeux pourraient trouver des applications dans la mesure de fortes doses de rayonnement. Ce probleme est discute en conclusion. (auteur)

  9. Illustrations

    OpenAIRE

    2016-01-01

    Planche 1. Corps et cakra tantriques. Wellcome MS Indic β511. Avec l'aimable autorisation du Wellcome Trust. Planche 2(a).Ṣaṭcakranirūpaṇacitra  : homologie entre corps tantrique et corps anatomique. Wellcome Library Or.P.B.Sansk.391. Avec l’aimable autorisation du Wellcome Trust. Planche 2(b).Ṣaṭcakranirūpaṇacitra  : mastiṣka et cerveau. Wellcome Library Or.P.B.Sansk.391. Avec l’aimable autorisation du Wellcome Trust. Planche 3 : Ṣaṭcakranirūpaṇacitra : anāhata cakra et plexus cardiaque. ...

  10. 4- BOUMALA

    African Journals Online (AJOL)

    Administrateur

    service d'alimentation en eau potable (AEP) si celui-ci est assuré par la commune ou les taxes qui peuvent être liées à des autorisations. (permis de construire, autorisation d'occupation du domaine public tel qu'un marché). Ce premier type de ressources s'inscrit dans un contexte où il est admis que les usagers sont tenus ...

  11. Optical trigger: a Cherenkov effect discriminator for high energy physics. Realisation and characterisation of thin films whose refractive index allow discrimination over a wide spectral range.; Le Trigger Optique: un discriminateur a effet Cherenkov pour la physique des particules. Realisation et caracterisation de couches minces dont l`indice de refraction autorise la discrimination sur un large domaine spectral

    Energy Technology Data Exchange (ETDEWEB)

    Delbart, A.

    1996-06-19

    The first part of this thesis sets the physical principles, and properties of actual Optical Triggers. For each of them, the cupel is sapphire made, and the external medium is liquid because of refractive index. The theory of Cherenkov emitted light cone explain how sapphire birefringence affects discrimination conditions.The second parts of the thesis (the main one) is focussed on study and realization of thin films for Optical Trigger. A layer characterization method has been developed by spectrophotometry, based on Perkin-Elmer laboratory device. Computerized simulation helped us to determine characteristics and limits of the studied device. (D.L.). Refs.

  12. Felix Vodička v kontextu současné literární teorie a historie: recepce a revize

    Czech Academy of Sciences Publication Activity Database

    Sládek, Ondřej

    2010-01-01

    Roč. 92, 1/2 (2010), s. 95-105 ISSN 0862-8459. [100 let generace prvních žáků PLK. Praha, 09.02.2009-09.02.2009] Institutional research plan: CEZ:AV0Z90560517 Keywords : theory of literature * literary history * Vodička, Felix * structuralism * Prague School Subject RIV: AJ - Letters, Mass-media, Audiovision

  13. Současné možnosti a prostředky enterální výživy

    OpenAIRE

    Hrnčířová, Naďa

    2014-01-01

    0BABSTRACT This thesis is focused on enteral nutrition. This issue is an integral part of intensive and resuscitation care, but it is also a part of standard and follow-up care. There are more and more new resources and the products for enteral nutrition are improving. The theoretical part deals with malnutrition, discusses the different components of nutrition. Much of the thesis forms ways of application of nutrition. The issue is a nasogastric tube, a nasojejunal tube, percutaneous endos...

  14. Hb G-Waimanalo [A1] or α64(E13)Asp→Asn (α1) (HBA1: c.193G>A) Observed in a Bulgarian Family.

    Science.gov (United States)

    Petkov, Georgi; Dimishkovska, Marija; Tsoneva Ivanova, Vanya; Yordanov, Georgi; Zdraveski, Alexandar; Plaseska-Karanfilska, Dijana

    2015-01-01

    The abnormal hemoglobin (Hb) with an aspartic acid to asparagine substitution at α64 has been found on both the α2- and α1-globin genes. It has been described in many different populations under different names, but never in Bulgaria. Using the recently proposed nomenclature, Hb G-Waimanalo [A1] refers to the HBA1: c.193G > A, while Hb G-Waimanalo [A2] refers to the HBA2: c.193G > A mutation. Here, we present the first family from Bulgaria with Hb G-Waimanalo [A1].

  15. Současná krize na Ukrajině: dopady na českou migrační politiku

    OpenAIRE

    Jarolímová, Tereza

    2015-01-01

    Current crisis in Ukraine: the impact on Czech migration policy Bc. Tereza Jarolímová Abstract In November 2013 protests in response on cancelation of Association Agreements preparations between EU and Ukraine stand on the beginning of crisis, which resulted in annexation of Crimea by Russian Federation and in armed conflict at Eastern Ukraine. Those events led to a significant deterioration of security and socioeconomic conditions and influenced migration flows in Ukraine. In April 2015 ther...

  16. Přínos současných českých skladatelů-pedagogů pro rozvoj dětské hudebnosti

    OpenAIRE

    Zdichová, Lucie

    2018-01-01

    This dissertation deals with the contribution of contemporary composer educators to the development of childrenʼs musicality. In the first chapter it touches on the theme of important pedagogical representatives in Bohemia, Moravia and Silesia in the 17th to 19th centuries, and briefly stops at our nation's teacher, Jan Ámos Komenský. The following chapters contain a questionnaire and the treatise on the life and educational activity of contemporary Czech composers and educators Eduard Douša,...

  17. Spor o Kochema a současné bádání nad raněnovověkou literaturou

    Czech Academy of Sciences Publication Activity Database

    Malura, Jan

    2009-01-01

    Roč. 57, č. 4 (2009), s. 561-570 ISSN 0009-0468 Institutional research plan: CEZ:AV0Z90560517 Keywords : Czech literature * Early Modern Period * Textology Subject RIV: AJ - Letters, Mass-media, Audiovision

  18. Současná pojetí vztahu mezi krátkodobou pamětí a vědomím

    Czech Academy of Sciences Publication Activity Database

    Špok, Dalibor

    2003-01-01

    Roč. 47, č. 5 (2003), s. 424-436 ISSN 0009-062X Institutional research plan: CEZ:AV0Z7025918 Keywords : Short - term memory * working memory * consciousness Subject RIV: AN - Psychology Impact factor: 0.232, year: 2003

  19. Časně eneolitická výšinná lokalita na Okrouhlíku v Praze-Libni

    Czech Academy of Sciences Publication Activity Database

    Dobeš, Miroslav

    2016-01-01

    Roč. 23, č. 1 (2016), s. 15-31 ISSN 0231-6390 Institutional support: RVO:67985912 Keywords : Early Eneolithic * hill top settlement * Okrouhlík Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Archaeology

  20. Utváření vztahu rodičů k předčasně narozeným dětem

    Czech Academy of Sciences Publication Activity Database

    Chlebounová, M.; Čermák, Ivo

    2013-01-01

    Roč. 57, č. 4 (2013), s. 307-316 ISSN 0009-062X Institutional support: RVO:68081740 Keywords : preterm labor * premature infants * parenting * relationship formation * fatherhood Subject RIV: AN - Psychology Impact factor: 0.292, year: 2013

  1. Decision n. 2009-DC-0103 made on the 1. of July 2010 by the Nuclear Safety Authority (ASN) defining obligations of quality assurance in radiotherapy

    International Nuclear Information System (INIS)

    2008-01-01

    This document addresses various aspects and issues: the general requirements of a quality management system, the leadership commitment on this aspect, organisational provisions, the documentation system and its control, the personnel responsibility, the study of risks associated with the radiotherapy process for the patients, the internal declaration of dysfunctions and undesirable situations, improvement actions planning, internal communication, records. These terms and others are more precisely defined in an appendix

  2. Deminutiva, jejich typy, užívání a proměny v současné češtině

    OpenAIRE

    Choulíková, Klára

    2011-01-01

    The goal of this paper is a reflection of the use, word-formation and semantics of diminutives in the contemporary Czech language. A special focus is given on new or marginal phenomena. A description of the system of the word-forming category of diminutives serves as a background for our analysis. The research is based on the comparison of different approaches described in specialized linguistic handbooks which are supplemented with findings from particular linguistic studies.

  3. Současné sociální změny, jejich důsledky a syndrom vyhoření

    Czech Academy of Sciences Publication Activity Database

    Kebza, V.; Šolcová, Iva

    2013-01-01

    Roč. 57, č. 4 (2013), s. 329-341 ISSN 0009-062X Institutional support: RVO:68081740 Keywords : burnout syndrome * unemployment * engagement * organizational civility Subject RIV: AN - Psychology Impact factor: 0.292, year: 2013

  4. Syndrom vyhoření – rekapitulace současného stavu poznání a perspektivy do budoucna

    Czech Academy of Sciences Publication Activity Database

    Kebza, V.; Šolcová, Iva

    2008-01-01

    Roč. 52, č. 4 (2008), s. 351-365 ISSN 0009-062X R&D Projects: GA ČR GA406/06/0747 Institutional research plan: CEZ:AV0Z70250504 Keywords : burnout syndrome * vital exhaustion * engagement Subject RIV: AN - Psychology Impact factor: 0.101, year: 2008

  5. DGT/ASN circular n. 04 of the 21. of April 2010 related to provisions for the prevention to ionizing ray exposure risks

    International Nuclear Information System (INIS)

    2010-01-01

    After an overview of the context of risk of exposure to ionizing radiation (potentially concerned activities, prevention policy based on radioprotection principles, regulation origin, radioprotection organization, specific inspection), this document presents the different regulatory provisions for the protection of workers against ionizing radiation hazards (scope of application, risk assessment, technical rules for workspace design, collective and individual protections, conditions for the follow-up of exposed workers, medical follow-up, work abnormal condition, radioprotection operating organisation, exposure to natural radioactivity). Then, a set of sheets is proposed, respectively containing regulatory information on employer obligations in terms of radioprotection, technical controls of radioprotection, individual protection equipment, worker information and education, radiological follow-up of classified workers, worker medical follow-up, work abnormal conditions, person with abilities in radioprotection, and a list of application decisions and orders

  6. Quantification of in vivo site-specific Asp isomerization and Asn deamidation of mAbs in animal serum using IP-LC-MS.

    Science.gov (United States)

    Mehl, John T; Sleczka, Bogdan G; Ciccimaro, Eugene F; Kozhich, Alexander T; Gilbertson, Deb G; Vuppugalla, Ragini; Huang, Christine S; Stevens, Brenda; Mo, Jingjie; Deyanova, Ekaterina G; Wang, Yun; Huang, Richard Yc; Chen, Guodong; Olah, Timothy V

    2016-08-01

    Isomerization of aspartic acid and deamidation of asparagine are two common amino acid modifications that are of particular concern if located within the complementarity-determining region of therapeutic antibodies. Questions arise as to the extent of modification occurring in circulation due to potential exposure of the therapeutic antibody to different pH regimes. To enable evaluation of site-specific isomerization and deamidation of human mAbs in vivo, immunoprecipitation (IP) has been combined with LC-MS providing selective enrichment, separation and detection of naive and modified forms of tryptic peptides comprising complementarity-determining region sequences. IP-LC-MS can be applied to simultaneously quantify in vivo drug concentrations and measure the extent of isomerization or deamidation in PK studies conducted during the drug discovery stage.

  7. Obraz ženy v současném českém umění

    OpenAIRE

    Zimmermannová, Vladimíra

    2011-01-01

    Zimmermannová, V. Depiction of Women in Contemporary Czech Art. /Graduation Thesis/ Prague 2010. Charles University in Prague. Faculty of Education. Department of Fine Art Education. Supervisor J. Bláha. This graduation thesis aims to describe and reflect on the views relating to the depiction of women, female corporality, identity, sexuality and other elements related to the topic of women in contemporary Czech art. The thesis tries to explore characteristic methods of expression and topical...

  8. Marihuana a současný životní styl dětí a mládeže

    OpenAIRE

    KOBRLOVÁ, Kateřina

    2008-01-01

    The work follows adolescents and their relation to marihuana. In the theoretic part, marihuana is not considered just as a drug. Other ways of using it are mentioned there, for example, it can be used as an alternative renewable raw material for industry and economy. The research part is focused on concrete dates gaining about adolescents with an experience in smoking marihuana and confirming the truth of research tasks made according to the theoretic part. The work is generally aimed to prov...

  9. Vliv časné imunitní stimulace a její odezva v animálním modelu schizofrenie

    Czech Academy of Sciences Publication Activity Database

    Tejkalová, H.; Kačer, P.; Růžičková, Š.; Klaschka, Jan; Horáček, J.

    2017-01-01

    Roč. 21, Suppl. 2 (2017), s. 53-55 ISSN 1211-7579 R&D Projects: GA ČR(CZ) GBP304/12/G069 Institutional support: RVO:67985807 Keywords : schizofrenie * imunitní systém * cytokiny * potkan * lipopolysacharid Subject RIV: FH - Neurology

  10. Současný stav poznání Žatce v raném středověku

    Czech Academy of Sciences Publication Activity Database

    Čech, Petr

    2008-01-01

    Roč. 60, č. 1 (2008), s. 36-60 ISSN 0323-1267 R&D Projects: GA ČR GA404/05/2671 Institutional research plan: CEZ:AV0Z80020508 Keywords : Early Middle Age * agglomeration * iron production * minting * ceramics * Bohemia * Žatec Subject RIV: AC - Archeology, Anthropology, Ethnology

  11. Analýza současné situace na trhu elektronických knih (e-book) v České republice

    OpenAIRE

    Kubeš, Adam

    2011-01-01

    The thesis "Analysis of the current situation on the market of electronic books (eBook) in the Czech Republic", deals with topics and issues of e-books and the current market situation in the Czech Republic. One of its objectives is to introduce readers to the world of e-books, show a brief history and development of books and e-books as a medium, getting to know what's happening in the U.S., and particularly on the Czech market. For this thesis, it was developed an online questionnaire "Elec...

  12. Historický a současný vývoj sesuvného území u Třebenic

    Czech Academy of Sciences Publication Activity Database

    Balek, Jan; Marek, Tomáš; Kadlečík, Pavel

    2015-01-01

    Roč. 2014, podzim (2015), s. 51-54 ISSN 0514-8057 Institutional support: RVO:67985891 Keywords : České středohoří Mts. * historical * current * landslide activity * monitoring Subject RIV: DE - Earth Magnetism, Geodesy, Geography

  13. Časná postdenervační depolarizace: vliv NO, acetylcholinu a glutamátu na chloridový transportér

    Czech Academy of Sciences Publication Activity Database

    Vyskočil, František

    2002-01-01

    Roč. 51, č. 4 (2002), s. 147-158 ISSN 0009-0557 R&D Projects: GA AV ČR IAA7011902; GA ČR GA305/02/1333; GA ČR GA202/02/1213 Institutional research plan: CEZ:AV0Z5011922 Keywords : acetylcholine * carbachol * glutamate Subject RIV: ED - Physiology

  14. Znalost pomístních jmen v Rožmitále pod Třemšínem - současný stav

    OpenAIRE

    Drnovcová, Zlata

    2010-01-01

    Minor place-names serve as a reliable and helpful source of identification without which it would be much more complicated to find one's way in the landscape. This master thesis focuses on the usage of toponyms in the city of Rožmitál pod Třemšínem. Their knowledge is not a matter of course for the locals. Some of the place names are no more current in communication, some of them still are, but only for some generations. This is influenced by the age, the length of living in the locality, the...

  15. Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions.

    Science.gov (United States)

    Culurgioni, Simone; Alfieri, Andrea; Pendolino, Valentina; Laddomada, Federica; Mapelli, Marina

    2011-12-27

    Coupling of spindle orientation to cellular polarity is a prerequisite for epithelial asymmetric cell divisions. The current view posits that the adaptor Inscuteable (Insc) bridges between Par3 and the spindle tethering machinery assembled on NuMALGNGαi(GDP), thus triggering apico-basal spindle orientation. The crystal structure of the Drosophila ortholog of LGN (known as Pins) in complex with Insc reveals a modular interface contributed by evolutionary conserved residues. The structure also identifies a positively charged patch of LGN binding to an invariant EPE-motif present on both Insc and NuMA. In vitro competition assays indicate that Insc competes with NuMA for LGN binding, displaying a higher affinity, and that it is capable of opening the LGN conformational switch. The finding that Insc and NuMA are mutually exclusive interactors of LGN challenges the established model of force generators assembly, which we revise on the basis of the newly discovered biochemical properties of the intervening components.

  16. Neolitické a časně eneolitické hroby z Prahy-Jihozápadního Města

    Czech Academy of Sciences Publication Activity Database

    Petriščáková, K.; Dobeš, Miroslav; Popelka, M.

    2016-01-01

    Roč. 33, 1-2 (2016), s. 335-349 ISSN 0231-5432 Institutional support: RVO:67985912 Keywords : Prague * Late Neolithic Period * Stroked Pottery Culture * Early Eneolithic Period * Jordanów Culture * graves Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Archaeology

  17. Psychosociální stres žen: Přehled současných poznatků

    Czech Academy of Sciences Publication Activity Database

    Šolcová, Iva

    1996-01-01

    Roč. 40, č. 3 (1996), s. 237-247 ISSN 0009-062X R&D Projects: GA ČR GA406/95/0736 Keywords : women's health * multiple roles * total work load * women's stress Subject RIV: AN - Psychology Impact factor: 0.122, year: 1995

  18. Odchylky od spisovné jazykové normy v současných právních textech

    Czech Academy of Sciences Publication Activity Database

    Smejkalová, Kamila; Prokšová, Hana

    2017-01-01

    Roč. 50, 7/8 (2017), s. 401-410 ISSN 0139-6005 Institutional support: RVO:68378092 Keywords : norm * codification * standard language * administrative style * orthography Subject RIV: AI - Linguistics OBOR OECD: Linguistics http://www.mvcr.cz/clanek/spravni-pravo-cislo-7-8-2017.aspx

  19. Transformace současných analýz slovesného folkloru - pohádka versus fantasy

    Czech Academy of Sciences Publication Activity Database

    Otčenášek, Jaroslav

    2010-01-01

    Roč. 58, č. 2 (2010), s. 105-109 ISSN 0350-0861 Institutional research plan: CEZ:AV0Z90580513 Keywords : interaction * oral folklore * fantasy * sci-fi * urban legend Subject RIV: AC - Archeology, Anthropology, Ethnology http://www.etno-institut.co.rs/GEI/GEI_VLIII_2/otcenasek%20LVVIII_2.pdf

  20. Druhá světová válka v současném českém filmu

    OpenAIRE

    FAKTOR, Jan

    2012-01-01

    The bachelor thesis World War II in Contemporary Czech Films deals with the way, how contemporary Czech filmmakers approach this historic period in their films and it focuses only on films shot after 1993. The aim of this thesis is to explain how are these films approached and what they try to convey to their viewers. The greatest attention would be payed to four films ? Tobruk, Dark Blue World, Divided We Fall and Lidice. This thesis will also focus on the comparison between real events and ...