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Sample records for nsls-ii injection system

  1. NSLS-II RF SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Rose, J.; Gash, W.; Holub, B.; Kawashima, Y.; Ma, H.; Towne, N.; Yeddulla, M.

    2011-03-28

    The NSLS-II is a new third generation light source being constructed at Brookhaven Lab. The storage ring is optimized for low emittance by use of damping wigglers to reduce the emittance to below 1 nm-rad. The RF systems are designed to provide stable beam through tight RF phase and amplitude stability requirements.

  2. BEAM CONTAINMENT SYSTEM FOR NSLS-II

    Energy Technology Data Exchange (ETDEWEB)

    Kramer, S.L.; Casey, W.; Job, P.K.

    2010-05-23

    The shielding design for the NSLS-II will provide adequate protection for the full injected beam loss in two periods of the ring around the injection point, but the remainder of the ring is shielded for lower losses of {le} 10% full beam. This will require a system to insure that beam losses don't exceed these levels for a period of time that could cause excessive radiation levels outside the shield walls. This beam containment system will measure, provide a level of control and alarm indication of the beam power losses along the beam path from the source (e-gun, linac) thru the injection system and the storage ring. This system will consist of collimators that will provide limits to (and potentially to measure) the beam miss-steering and control the loss points of the charge and monitors that will measure the average beam current losses along the beam path and alarm when this beam power loss exceeds the level set by the shielding specifications. This will require some new ideas in beam loss detection capability and collimation. The initial planning and R&D program will be presented.

  3. NSLS-II Radio Frequency Systems

    Energy Technology Data Exchange (ETDEWEB)

    Rose J.; Gao F.; Goel, A.; Holub, B.; Kulpin, J.; Marques, C.; Yeddulla, M.

    2015-05-03

    The National Synchrotron Light Source II is a 3 GeV X-ray user facility commissioned in 2014. The NSLS-II RF system consists of the master oscillator, digital low level RF controllers, linac, booster and storage ring RF sub-systems, as well as a supporting cryogenic system. Here we will report on RF commissioning and early operation experience of the system.

  4. Design of the NSLS-II Top-Off Safety System

    Energy Technology Data Exchange (ETDEWEB)

    Fliller, III R. [Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source; Doom, L. [Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source; Ganetis, G. [Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source; Hetzel, C. [Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source; Job, P. K. [Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source; Li, Y. [Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source; Shaftan, T. [Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source; Sharma, S. [Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source; Singh, O. [Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source; Wang, G. M. [Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source; Xia, Z. [Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source

    2015-05-03

    The NSLS-II accelerators finished commissioning in the fall of 2014, with beamline commissioning underway. Part of the design for the NSLS-II is to operate in top off mode. The Top Off Safety System (TOSS) is presently being installed. In this report we discuss the Top Off Safety System design and implementation, along with the necessary tracking results and radiological calculations.

  5. NSLS-II RF Cryogenic System

    Energy Technology Data Exchange (ETDEWEB)

    Rose, J.; Dilgen, T.; Gash, B.; Gosman, J.; Mortazavi, P.; Papu, J.; Ravindranath, V.; Sikora, R.; Sitnikov, A.; Wilhelm, H.; Jia, Y.; Monroe, C.

    2015-05-03

    The National Synchrotron Light Source II is a 3 GeV X-ray user facility commissioned in 2014. A new helium refrigerator system has been installed and commissioned to support the superconducting RF cavities in the storage ring. Special care was taken to provide very stable helium and LN2 pressures and flow rates to minimize microphonics and thermal effects at the cavities. Details of the system design along with commissioning and early operations data will be presented.

  6. Commissioning and Early Operation for the NSLS-II Booster RF System

    Energy Technology Data Exchange (ETDEWEB)

    Marques, C. [Brookhaven National Lab. (BNL), Upton, NY (United States); Cupolo, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Davila, P. [Brookhaven National Lab. (BNL), Upton, NY (United States); Gao, F. [Brookhaven National Lab. (BNL), Upton, NY (United States); Goel, A. [Brookhaven National Lab. (BNL), Upton, NY (United States); Holub, B. [Brookhaven National Lab. (BNL), Upton, NY (United States); Kulpin, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); McDonald, K. [Brookhaven National Lab. (BNL), Upton, NY (United States); Oliva, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Papu, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ramirez, G. [Brookhaven National Lab. (BNL), Upton, NY (United States); Rose, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Sikora, R. [Brookhaven National Lab. (BNL), Upton, NY (United States); Sorrentino, C. [Brookhaven National Lab. (BNL), Upton, NY (United States); Towne, N. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-05-03

    The National Synchrotron Light Source II (NSLS-II) at Brookhaven National Laboratory (BNL) is a third generation 3GeV, 500mA synchrotron light source. We discuss the booster synchrotron RF system responsible for providing power to accelerate an electron beam from 200MeV to 3GeV. The RF system design and construction are complete and is currently in the operational phase of the NSLS-II project. Preliminary operational data is also discussed.

  7. Commissioning and Early Operation Experience of the NSLS-II Storage Ring RF System

    Energy Technology Data Exchange (ETDEWEB)

    Gao, F.; Rose, J.; Cupolo, J.; Dilgen, T.; Rose, B.; Gash, W.; Ravindranath, V.; Yeddulla, M.; Papu, J.; Davila, P.; Holub, B.; Tagger, J.; Sikora, R.; Ramirez, G.; Kulpin, J.

    2015-05-03

    The National Synchrotron Light Source II (NSLS-II) is a 3 GeV electron X-ray user facility commissioned in 2014. The storage ring RF system, essential for replenishing energy loss per turn of the electrons, consists of digital low level RF controllers, 310 kW CW klystron transmitters, CESR-B type superconducting cavities, as well as a supporting cryogenic system. Here we will report on RF commissioning and early operation experience of the system for beam current up to 200mA.

  8. NSLS-II Beam Diagnostics Overview

    Energy Technology Data Exchange (ETDEWEB)

    Singh,O.; Alforque, R.; Bacha, B.; Blednykh, A.; Cameron, P.; Cheng, W.; Dalesio, L. B.; Della Penna, A. J.; doom, L.; Fliller, R. P.; Ganetis, G.; Heese, R.; Hseuh, H-C.; Johnson, E. D.; Kosciuk, b. N.; Kramer, S. L.; Krinsky, S.; Mead, J.; Ozaki, S.; Padrazo, D.; Pinayev, I.; Ravindranath, R. V.; Rose, J.; Shaftan, T.; Sharma, S.; Skaritka, J.; Tanabe, T.; Tian, Y.; Willeke, F. J.; Yu, L-H.

    2009-05-04

    A new 3rd generation light source (NSLS-II) is in the early stages of construction at Brookhaven National Laboratory. The NSLS-II facility will provide ultra high brightness and flux with exceptional beam stability. It presents several challenges for diagnostics and instrumentation, related to the extremely small emittance. In this paper, we present an overview of all planned instrumentation systems, results from research and development activities; and then focus on other challenging aspects.

  9. Harmonic Cavity Performance for NSLS-II

    CERN Document Server

    Blednykh, Alexei; Podobedov, Boris; Rose, James; Towne, Nathan A; Wang, Jiunn-Ming

    2005-01-01

    NSLS-II is a 3 GeV ultra-high brightness storage ring that is planned to succeed the present NSLS rings at Brookhaven. Ultra-low emittance bunch combined with a short bunch length results in the Touschek lifetime of only a few hours, which strongly advocates including harmonic RF in the baseline design of NSLS-II. This paper describes the required harmonic RF parameters, trade-offs between the possible choices and the expected system performance, including the implications on lifetime and instabilities.

  10. NSLS-II Digital RF Controller Logic and Applications

    Energy Technology Data Exchange (ETDEWEB)

    Holub, B. [Brookhaven National Lab. (BNL), Upton, NY (United States); Gao, F. [Brookhaven National Lab. (BNL), Upton, NY (United States); Kulpin, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Marques, C. [Brookhaven National Lab. (BNL), Upton, NY (United States); Oliva, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Rose, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Towne, N. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-05-03

    The National Synchrotron Light Source II (NSLS-II) accelerator consists of the Storage Ring, the Booster Ring and Linac along with their associated cavities. Given the number, types and variety of functions of these cavities, we sought to limit the logic development effort by reuse of parameterized code on one hardware platform. Currently there are six controllers installed in the NSLS-II system. There are two in the Storage ring, two in the Booster ring, one in the Linac and one in the Master Oscillator Distribution system.

  11. Commissioning of NSLS-II

    Energy Technology Data Exchange (ETDEWEB)

    Willeke, F.

    2015-05-03

    NSLS-II, the new 3rd generation light source at BNL was designed for a brightness of 1022 photons s-1mm-2mrad-2 (0.1%BW)-1. It was constructed between 2009 and 2014. The storage ring was commissioned in April 2014 which was followed by insertion device and beamline commissioning in the fall of 2014. All ambitious design parameters of the facility have already been achieved except for commissioning the full beam intensity of 500mA which requires more RF installation. This paper reports on the results of commissioning.

  12. Synchrotron X-ray tests of an L-shaped laterally graded multilayer mirror for the analyzer system of the ultra-high-resolution IXS spectrometer at NSLS-II.

    Science.gov (United States)

    Honnicke, Marcelo G; Keister, Jeffrey W; Conley, Raymond; Kaznatcheev, Konstantine; Takacs, Peter Z; Coburn, David Scott; Reffi, Leo; Cai, Yong Q

    2011-11-01

    Characterization and testing of an L-shaped laterally graded multilayer mirror are presented. This mirror is designed as a two-dimensional collimating optics for the analyzer system of the ultra-high-resolution inelastic X-ray scattering (IXS) spectrometer at National Synchrotron Light Source II (NSLS-II). The characterization includes point-to-point reflectivity measurements, lattice parameter determination and mirror metrology (figure, slope error and roughness). The synchrotron X-ray test of the mirror was carried out reversely as a focusing device. The results show that the L-shaped laterally graded multilayer mirror is suitable to be used, with high efficiency, for the analyzer system of the IXS spectrometer at NSLS-II.

  13. NSLS-II Preliminary Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Dierker, S.

    2007-11-01

    Following the CD0 approval of the National Synchrotron Light Source II (NSLS-II) during August 2005, Brookhaven National Laboratory prepared a conceptual design for a worldclass user facility for scientific research using synchrotron radiation. DOE SC review of the preliminary baseline in December 2006 led to the subsequent CD1 approval (approval of alternative selection and cost range). This report is the documentation of the preliminary design work for the NSLS-II facility. The preliminary design of the Accelerator Systems (Part 1) was developed mostly based of the Conceptual Design Report, except for the Booster design, which was changed from in-storage-ring tunnel configuration to in external- tunnel configuration. The design of beamlines (Part 2) is based on designs developed by engineering firms in accordance with the specification provided by the Project. The conventional facility design (Part 3) is the Title 1 preliminary design by the AE firm that met the NSLS-II requirements. Last and very important, Part 4 documents the ES&H design and considerations related to this preliminary design. The NSLS-II performance goals are motivated by the recognition that major advances in many important technology problems will require scientific breakthroughs in developing new materials with advanced properties. Achieving this will require the development of new tools that will enable the characterization of the atomic and electronic structure, chemical composition, and magnetic properties of materials, at nanoscale resolution. These tools must be nondestructive, to image and characterize buried structures and interfaces, and they must operate in a wide range of temperatures and harsh environments. The NSLS-II facility will provide ultra high brightness and flux and exceptional beam stability. It will also provide advanced insertion devices, optics, detectors, and robotics, and a suite of scientific instruments designed to maximize the scientific output of the facility

  14. NSLS-II Preliminary Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Dierker, S.

    2007-11-01

    Following the CD0 approval of the National Synchrotron Light Source II (NSLS-II) during August 2005, Brookhaven National Laboratory prepared a conceptual design for a worldclass user facility for scientific research using synchrotron radiation. DOE SC review of the preliminary baseline in December 2006 led to the subsequent CD1 approval (approval of alternative selection and cost range). This report is the documentation of the preliminary design work for the NSLS-II facility. The preliminary design of the Accelerator Systems (Part 1) was developed mostly based of the Conceptual Design Report, except for the Booster design, which was changed from in-storage-ring tunnel configuration to in external- tunnel configuration. The design of beamlines (Part 2) is based on designs developed by engineering firms in accordance with the specification provided by the Project. The conventional facility design (Part 3) is the Title 1 preliminary design by the AE firm that met the NSLS-II requirements. Last and very important, Part 4 documents the ES&H design and considerations related to this preliminary design. The NSLS-II performance goals are motivated by the recognition that major advances in many important technology problems will require scientific breakthroughs in developing new materials with advanced properties. Achieving this will require the development of new tools that will enable the characterization of the atomic and electronic structure, chemical composition, and magnetic properties of materials, at nanoscale resolution. These tools must be nondestructive, to image and characterize buried structures and interfaces, and they must operate in a wide range of temperatures and harsh environments. The NSLS-II facility will provide ultra high brightness and flux and exceptional beam stability. It will also provide advanced insertion devices, optics, detectors, and robotics, and a suite of scientific instruments designed to maximize the scientific output of the facility

  15. Beam Loss Monitors for NSLS-II Storage Ring

    Energy Technology Data Exchange (ETDEWEB)

    Kramer, S.L.; Cameron, P.

    2011-03-28

    The shielding for the NSLS-II storage ring will provide adequate protection for the full injected beam losses in two cells of the ring around the injection point, but the remainder of the ring is shielded for lower losses of <10% top-off injection beam current. This will require a system to insure that beam losses do not exceed levels for a period of time that could cause excessive radiation exposure outside the shield walls. This beam Loss Control and Monitoring system will have beam loss monitors that will measure where the beam charge is lost around the ring, to warn operators if losses approach the design limits. To measure the charge loss quantitatively, we propose measuring the electron component of the shower as beam electrons hit the vacuum chamber (VC) wall. This will be done using the Cerenkov light as electrons transit ultra-pure fused silica rods placed close to the inner edge of the VC. The entire length of the rod will collect light from the electrons of the spread out shower resulting from the small glancing angle of the lost beam particles to the VC wall. The design and measurements results of the prototype Cerenkov BLM will be presented.

  16. Design of the NSLS-II Linac Front End Test Stand

    Energy Technology Data Exchange (ETDEWEB)

    Fliller III, R.; Johanson, M.; Lucas, M.; Rose, J.; Shaftan, T.

    2011-03-28

    The NSLS-II operational parameters place very stringent requirements on the injection system. Among these are the charge per bunch train at low emittance that is required from the linac along with the uniformity of the charge per bunch along the train. The NSLS-II linac is a 200 MeV linac produced by Research Instruments Gmbh. Part of the strategy for understanding to operation of the injectors is to test the front end of the linac prior to its installation in the facility. The linac front end consists of a 100 kV electron gun, 500 MHz subharmonic prebuncher, focusing solenoids and a suite of diagnostics. The diagnostics in the front end need to be supplemented with an additional suite of diagnostics to fully characterize the beam. In this paper we discuss the design of a test stand to measure the various properties of the beam generated from this section. In particular, the test stand will measure the charge, transverse emittance, energy, energy spread, and bunching performance of the linac front end under all operating conditions of the front end.

  17. Multilayer Laue Lens Growth at NSLS-II

    Energy Technology Data Exchange (ETDEWEB)

    Conley R.; Bouet, N.; Lauer, K.; Carlucci-Dayton, M.; Biancarosa, J.; Boas, L.; Drannbauer, J.; Feraca, J.; Rosenbaum, L.

    2012-08-15

    The new NSLS-II deposition laboratory has been commissioned to include a variety of thin-film characterization equipment and a next-generation deposition system. The primary goal for this effort is R&D on the multilayer Laue lens (MLL), which is a new type of x-ray optic with the potential for an unprecedented level of x-ray nano-focusing. This unique deposition system contains many design features in order to facilitate growth of combined depth-graded and laterally graded multilayers with precise thickness control over many thousands of layers, providing total film growth in one run of up to 100 {micro}m thick or greater. A precision in-vacuum linear motor servo system raster scans a substrate over an array of magnetrons with shaped apertures at well-defined velocities to affect a multilayer coating. The design, commissioning, and performance metrics of the NSLS-II deposition system will be discussed. Latest growth results of both MLL and reflective multilayers in this machine will be presented.

  18. Considerations for NSLS-II Synchrotron Radiation Protection When Operating Damping Wigglers at Low Machine Energy

    Energy Technology Data Exchange (ETDEWEB)

    Seletskiy, S. [Brookhaven National Lab. (BNL), Upton, NY (United States). Photon Sciences Dept.; Podobedov, B. [Brookhaven National Lab. (BNL), Upton, NY (United States). Photon Sciences Dept.

    2015-12-30

    The NSLS-II storage ring vacuum chamber, including frontends (FE) and beamlines (BL), is protected from possible damage from synchrotron radiation (SR) emitted from insertion devices (IDs) by a dedicated active interlock system (AIS). The system monitors electron beam position and angle and triggers a beam dump if the beam orbit is outside of the active interlock envelope (AIE). The AIE was calculated under the assumptions of 3 GeV beam energy and ID gaps set to their minimum operating values (i.e. “fully closed”). Recently it was proposed to perform machine studies that would ramp the stored beam energy significantly below the nominal operational value of 3 GeV. These studies may potentially include the use of NSLS-II damping wigglers (DWs) for electron beam emittance reduction and control.

  19. Overview of Beam Instrumentation and Diagnostics for the NSLS-II Project

    Energy Technology Data Exchange (ETDEWEB)

    Singh,O.

    2008-05-04

    A new, ultra-bright 3rd generation light source, the NSLS-II Project, is planned to be built at Brookhaven National Laboratory. The light source being developed will have unprecedently small beam horizontal emittance and will provide the radiation sources with a brightness of 3 x 10{sup 21} photons/sec/0.1%BW/mm{sup 2}/mrad{sup 2}. In this paper we present the detailed specifications and a comprehensive description of the planned beam instrumentation system and the first results of the ongoing instrumentation R&D activities on beyond state-of-the-art subsystems.

  20. Development of the XFP beamline for x-ray footprinting at NSLS-II

    Energy Technology Data Exchange (ETDEWEB)

    Bohon, Jen, E-mail: jbohon@bnl.gov; Sullivan, Michael; Abel, Don; Toomey, John; Chance, Mark R., E-mail: mark.chance@case.edu [Case Center for Synchrotron Biosciences, Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH (United States); Dvorak, Joseph [Brookhaven National Laboratory, Upton, NY (United States)

    2016-07-27

    For over a decade, synchrotron-based footprinting studies at the NSLS X28C beamline have provided unique insights and approaches for examining the solution-state structures of large macromolecular assemblies, membrane proteins, and soluble proteins, for time-resolved studies of macromolecular dynamics, and most recently for in vivo studies of RNA-protein complexes. The transition from NSLS to NSLS-II has provided the opportunity to create an upgraded facility for the study of increasingly complex systems; progress on the development of the XFP (X-ray Footprinting for In Vitro and In Vivo Structural Studies of Biological Macromolecules) beamline at NSLS-II is presented here. The XFP beamline will utilize a focused 3-pole wiggler source to deliver a high flux density x-ray beam, where dynamics can be studied on the microsecond to millisecond timescales appropriate for probing biological macromolecules while minimizing sample perturbation. The beamline optics and diagnostics enable adaptation of the beam size and shape to accommodate a variety of sample morphologies with accurate measurement of the incident beam, and the upgrades in sample handling and environment control will allow study of highly sensitive or unstable samples. The XFP beamline is expected to enhance relevant flux densities more than an order of magnitude from that previously available at X28C, allowing static and time-resolved structural analysis of highly complex samples that have previously pushed the boundaries of x-ray footprinting technology. XFP, located at NSLS-II 17-BM, is anticipated to become available for users in 2016.

  1. Shielding NSLS-II light source: Importance of geometry for calculating radiation levels from beam losses

    Science.gov (United States)

    Kramer, S. L.; Ghosh, V. J.; Breitfeller, M.; Wahl, W.

    2016-11-01

    Third generation high brightness light sources are designed to have low emittance and high current beams, which contribute to higher beam loss rates that will be compensated by Top-Off injection. Shielding for these higher loss rates will be critical to protect the projected higher occupancy factors for the users. Top-Off injection requires a full energy injector, which will demand greater consideration of the potential abnormal beam miss-steering and localized losses that could occur. The high energy electron injection beam produces significantly higher neutron component dose to the experimental floor than a lower energy beam injection and ramped operations. Minimizing this dose will require adequate knowledge of where the miss-steered beam can occur and sufficient EM shielding close to the loss point, in order to attenuate the energy of the particles in the EM shower below the neutron production threshold (Designing supplemental shielding near the loss point using the analytic shielding model is shown to be inadequate because of its lack of geometry specification for the EM shower process. To predict the dose rates outside the tunnel requires detailed description of the geometry and materials that the beam losses will encounter inside the tunnel. Modern radiation shielding Monte-Carlo codes, like FLUKA, can handle this geometric description of the radiation transport process in sufficient detail, allowing accurate predictions of the dose rates expected and the ability to show weaknesses in the design before a high radiation incident occurs. The effort required to adequately define the accelerator geometry for these codes has been greatly reduced with the implementation of the graphical interface of FLAIR to FLUKA. This made the effective shielding process for NSLS-II quite accurate and reliable. The principles used to provide supplemental shielding to the NSLS-II accelerators and the lessons learned from this process are presented.

  2. MULTIOBJECTIVE DYNAMIC APERTURE OPTIMIZATION AT NSLS-II

    Energy Technology Data Exchange (ETDEWEB)

    Yang, L.; Li, Y.; Guo, W.; Krinsky, S.

    2011-03-28

    In this paper we present a multiobjective approach to the dynamic aperture (DA) optimization. Taking the NSLS-II lattice as an example, we have used both sextupoles and quadrupoles as tuning variables to optimize both on-momentum and off-momentum DA. The geometric and chromatic sextupoles are used for nonlinear properties while the tunes are independently varied by quadrupoles. The dispersion and emittance are fixed during tunes variation. The algorithms, procedures, performances and results of our optimization of DA will be discussed and they are found to be robust, general and easy to apply to similar problems.

  3. NSLS-II storage ring insertion device and front-end commissioning and operation

    Energy Technology Data Exchange (ETDEWEB)

    Wang, G., E-mail: gwang@bnl.gov; Shaftan, T.; Amundsen, C.; Bassi, G.; Bengtsson, J.; Blednykh, A.; Blum, E.; Cheng, W.; Choi, J.; Chubar, O.; Corwin, T.; Davidsaver, M.; Doom, L.; Guo, W.; Harder, D.; Hidaka, Y.; Hu, Y.; Ilinski, P.; Kitegi, C.; Kramer, S. [Brookhaven National Laboratory, Upton, NY 11973 (United States); and others

    2016-07-27

    The National Synchrotron Light Source II (NSLS-II) is a state of the art 3 GeV third generation light source at Brookhaven National Laboratory. During spring/ summer of 2014, the storage ring was commissioned up to 50 mA without insertion devices. In the fall of 2014, we began commissioning of the project beamlines, which included seven insertion devices on six ID ports. Beamlines IXS, HXN, CSX-1, CSX-2, CHX, SRX, and XPD-1 consist of elliptically polarized undulator (EPU), damping wigglers (DW) and in-vacuum undulators (IVU) covering from VUV to hard x-ray range. In this paper, experience with commissioning and operation is discussed. We focus on reaching storage ring performance with IDs, including injection, design emittance, compensation of orbit distortions caused by ID residual field, source point stability, beam alignment and tools for control, monitoring and protection of the ring chambers from ID radiation.

  4. NSLS-II Control of Dynamic Aperture

    Energy Technology Data Exchange (ETDEWEB)

    Bengtsson,J.

    2008-10-31

    We have outlined how, by an intuitive approach, the on- and off-momentum dynamic aperture for a synchrotron light source can be estimated from a nonlinear system of algebraic equations for the sextupole/multipole strengths. The approach has only two free parameters: the relative weight for resonance vs. tune shift terms and the tune footprint for stable trajectories in a modern third generation synchrotron light source. In other words, we have established a control theory approach for the medium term (10{sup 3} turns) stability for a dynamic system described by a nonlinear system of ordinary differential equations. Equipped with a predictive, quantitative model for stability, we have then evaluated how to improve the control of the dynamics by analyzing and modifying the properties of the corresponding algebraic system. In particular, by changing the number- and characteristics of the parameters, i.e., we have not evaluated how the underlying (linear) optics could be improved. We have also validated our conjectures by numerical simulations with a realistic model. Presumably, our conclusions, summarized in Section 1.0, are a direct result of the presented analysis and observations.

  5. NSLS-II injector commissioning and initial operation

    Energy Technology Data Exchange (ETDEWEB)

    Bacha, B.; Blum, E.; Bassi, B.; Bengtsson, J.; Blednykh, A.; Buda, S.; Cheng, W.; Choi, J.; Cuppolo, J.; D Alsace, R.; Davidsaver, M.; DeLong, J.; Doom, L.; Durfee, d.; fliller, R.; Fulkerson, M.; Ganetis, G.; Gao, F.; Gardner, C.; Guo, W.; Heese, R.; Hidaka, Y.; Hu, Y.; Johanson, M.; Kosciuk, B.; Kowalski, S.; Dramer, S.; Krinsky, S.; Li, Y.; Louie, W.; Maggipinto, M.; Marino, P.; Mead, J.; Oliva, G.; Padrazo, D.; Pedersen, K.; Podobedov, B.; Rainer, R.; Rose, J.; Santana, M.; Seletskiy, S.; Shaftan, T.; Singh, O.; Singh, P.; Smalyuk, V.; Smith, R.; Summers, T.; Tagger, J.; Tian, Y.; Wahl, W.; Wang, G.; Weiner, G.; Willeke, F.; Yang, L.; Yang, X.; Zeitler, E.; Zitvogel, E.; Zuhoski, P.

    2015-05-03

    The injector for the National Synchrotron Light Source II (NSLS-II) storage ring consists of a 3 GeV booster synchrotron and a 200 MeV S-band linac. The linac was designed to produce either a single bunch with a charge of 0.5 nC of electrons or a train of bunches up to 300 ns long containing a total charge of 15 nC. The booster was designed to accelerate up to 15 nC each cycle in a train of bunches up to 300 ns long. Linac commissioning was completed in April 2012. Booster commissioning was started in November 2013 and completed in March 2014. All of the significant design goals were satisfied including beam emittance, energy spread, and transport efficiency. While the maximum booster charge accelerated was only 10 nC, this has proven to be more than sufficient for storage ring commissioning and operation. The injector has operated reliably during storage ring operation since then. Results will be presented showing measurements of linac and booster operating parameters achieved during commissioning and initial operation. Operating experience and reliability during the first year of NSLS-II operation will be discussed.

  6. NSLS-II: Nonlinear Model Calibration for Synchrotrons

    Energy Technology Data Exchange (ETDEWEB)

    Bengtsson, J.

    2010-10-08

    This tech note is essentially a summary of a lecture we delivered to the Acc. Phys. Journal Club Apr, 2010. However, since the estimated accuracy of these methods has been naive and misleading in the field of particle accelerators, i.e., ignores the impact of noise, we will elaborate on this in some detail. A prerequisite for a calibration of the nonlinear Hamiltonian is that the quadratic part has been understood, i.e., that the linear optics for the real accelerator has been calibrated. For synchrotron light source operations, this problem has been solved by the interactive LOCO technique/tool (Linear Optics from Closed Orbits). Before that, in the context of hadron accelerators, it has been done by signal processing of turn-by-turn BPM data. We have outlined how to make a basic calibration of the nonlinear model for synchrotrons. In particular, we have shown how this was done for LEAR, CERN (antiprotons) in the mid-80s. Specifically, our accuracy for frequency estimation was {approx} 1 x 10{sup -5} for 1024 turns (to calibrate the linear optics) and {approx} 1 x 10{sup -4} for 256 turns for tune footprint and betatron spectrum. For a comparison, the estimated tune footprint for stable beam for NSLS-II is {approx}0.1. Since the transverse damping time is {approx}20 msec, i.e., {approx}4,000 turns. There is no fundamental difference for: antiprotons, protons, and electrons in this case. Because the estimated accuracy for these methods in the field of particle accelerators has been naive, i.e., ignoring the impact of noise, we have also derived explicit formula, from first principles, for a quantitative statement. For e.g. N = 256 and 5% noise we obtain {delta}{nu} {approx} 1 x 10{sup -5}. A comparison with the state-of-the-arts in e.g. telecomm and electrical engineering since the 60s is quite revealing. For example, Kalman filter (1960), crucial for the: Ranger, Mariner, and Apollo (including the Lunar Module) missions during the 60s. Or Claude Shannon et al

  7. Achieving Vibration Stability of the NSLS-II Hard X-ray Nanoprobe Beamline

    Energy Technology Data Exchange (ETDEWEB)

    Simos, N.

    2010-08-30

    The Hard X-ray Nanoprobe (HXN) Beamline of National Synchrotron Light Source II (NSLS-lI) requires high levels of stability in order to achieve the desired instrument resolution. To ensure that the design of the endstation helps meet the stringent criteria and that natural and cultural vibration is mitigated both passively and actively, a comprehensive study complimentary to the design process has been undertaken. Vibration sources that have the potential to disrupt sensitive experiments such as wind, traffic and NSLS II operating systems have been studied using state of the art simulations and an array of field data. Further, final stage vibration isolation principles have been explored in order to be utilized in supporting endstation instruments. This paper presents results of the various study aspects and their influence on the HXN design optimization.

  8. NSLS-II X-ray diagnostics development

    CERN Document Server

    Ilinski, Petr

    2013-01-01

    NSLS-II x-ray diagnostics will provide continuous online data of electron beam dimensions, which will be used to derive electron beam emittance and energy spread. It will also provide information of electron beam tilt for coupling evaluation. X-ray diagnostics will be based on imaging of bending magnet and three-pole wiggler synchrotron radiation sources. Diagnostics from three-pole wiggler source will be used to derive particles energy spread. Beta and dispersion functions will have to be evaluated for emittance and particles energy spread calculations. Due to small vertical source sizes imaging need to be performed in x-ray energy range. X-ray optics with high numerical aperture, such as compound refractive lens, will be used to achieve required spatial resolution. Optical setups with different magnifications in horizontal and vertical directions fill be employed to deal with large aspect ratio of the source. X-ray diagnostics setup will include x-ray imaging optics, monochromatization, x-ray imaging and re...

  9. The sub-micron resolution X-ray spectroscopy beamline at NSLS-II

    Science.gov (United States)

    De Andrade, V.; Thieme, J.; Northrup, P.; Yao, Y.; Lanzirotti, A.; Eng, P.; Shen, Q.

    2011-09-01

    For many research areas such as life, environmental, earth or material sciences, novel analytical resources have to be developed for an advance understanding of complex natural and engineered systems that are heterogeneous on the micron to the tenths of microns scale. NSLS-II at BNL will be a synchrotron radiation source with an ultra-high brilliance delivering a high current (500 mA). One of the 1st six NSLS-II beamlines will be the Sub-micron Resolution X-ray spectroscopy beamline (SRX), dedicated as an analytical tool to study complex systems on a sub-micron length scale. SRX will comprise two branches thanks to a canted setup with two undulators: the first branch using Kirkpatrick-Baez mirrors as focusing optics will cover the energy range of 4.65-23 keV, allowing for XANES experiments from the Ti to the Rh K-edge. Thanks to a horizontally deflecting double crystal monochromator with maximum stability, a set of slits located on the secondary source, and two sets of complementary and quickly interchangeable KB mirrors, spectroscopy with very high spectral and spatial resolution will be achieved. The spot size will almost fully cover a range from 60×60 to 1300×500 nm 2, providing an attractive adaptability of the observation scale. A 1.5 m long IVU21 will serve as a light source. The expected high flux in a sub-micron-spot (5×10 12 and 7×10 13 ph s -1 at maximum and lowest resolutions) will open new possibilities for spectromicroscopy of trace elements. The 2nd canted undulator will serve as an independent light source for the second branch designed for experiments with X-ray energies in the range of 2-15 keV. Using Fresnel zone plates, the spatial resolution aimed for is around 30 nm with up to 7×10 9 ph s -1 in the spot. This branch would be attractive for many biological applications from life and environmental science due to low-Z elements of interest within that energy range. In both experimental stations, X-ray fluorescence will be used for imaging

  10. Safe operating conditions for NSLS-II Storage Ring Frontends commissioning

    Energy Technology Data Exchange (ETDEWEB)

    Seletskiy, S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Amundsen, C. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ha, K. [Brookhaven National Lab. (BNL), Upton, NY (United States); Hussein, A. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-04-02

    The NSLS-II Storage Ring Frontends are designed to safely accept the synchrotron radiation fan produced by respective insertion device when the electron beam orbit through the ID is locked inside the predefined Active Interlock Envelope. The Active Interlock is getting enabled at a particular beam current known as AI safe current limit. Below such current the beam orbit can be anywhere within the limits of the SR beam acceptance. During the FE commissioning the beam orbit is getting intentionally disturbed in the particular ID. In this paper we explore safe operating conditions for the Frontends commissioning.

  11. Achieving Stability Requirements for Nanoprobe and Long Beam Lines at NSLS II. A Comprehensive Study

    Energy Technology Data Exchange (ETDEWEB)

    Simos,N.; Fallier, M.; Hill, J.; Berman, L.; Evans-Lutterodt, K.; Broadbent, A.

    2008-06-23

    Driven by beam stability requirements at the NSLS II synchrotron, such that the desired small beam sizes and high brightness are both realized and stable, a comprehensive study has been launched seeking to provide assurances that stability at the nanometer level at critical x-ray beam-lines, is achievable, given the natural and cultural vibration environment at the selected site. The study consists of (a) an extensive investigation of the site to evaluate the existing ground vibration, in terms of amplitude, frequency content and coherence, and (b) of a numerical study of wave propagation and interaction with the infrastructure of the sensitive lines. The paper presents results from both aspects of the study.

  12. Initial performances of first undulator-based hard x-ray beamlines of NSLS-II compared to simulations

    Energy Technology Data Exchange (ETDEWEB)

    Chubar, Oleg, E-mail: chubar@bnl.gov; Chu, Yong S.; Huang, Xiaojing; Kalbfleisch, Sebastian; Yan, Hanfei; Shaftan, Timur; Wang, Guimei; Cai, Yong Q.; Suvorov, Alexey; Fluerasu, Andrei; Wiegart, Lutz; Chen-Wiegart, Yu-chen Karen; Thieme, Juergen; Williams, Garth; Idir, Mourad; Tanabe, Toshiya; Zschack, Paul; Shen, Qun [National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY 11973 (United States)

    2016-07-27

    Commissioning of the first X-ray beamlines of NSLS-II included detailed measurements of spectral and spatial distributions of the radiation at different locations of the beamlines, from front-ends to sample positions. Comparison of some of these measurement results with high-accuracy calculations of synchrotron (undulator) emission and wavefront propagation through X-ray transport optics, performed using SRW code, is presented.

  13. From the meso to the nanoscopic scale through synchrotron imaging approaches: advances and near future at the NSLS-II SRX beamline

    Science.gov (United States)

    De Andrade, V.; Thieme, J.; Ganne, J.; Beck, P.; Fayard, B.; Salomé, M.

    2012-12-01

    Earth and planetary samples are commonly complex polycrystalline systems with various scale-level chemical and structural heterogeneities. They can present various crystallinity states, fine mechanical mixings of phases within a micrometer cube, micro-domains differentially affected by diverse geodynamic events. During the last decade, many questions in Earth Sciences were addressed with synchrotron techniques. Indeed, these big instruments now worldwide spreads are well equipped for unraveling the wealth of information stored in geomaterials. A large spectrum of cutting edge techniques (enabling phase identification, 3D chemical imaging, elemental speciation determination…) is available with mm to ~10 nm large X-ray beams, with sensitivity in some cases below the ppm. In this presentation, we will first underscore the predominant contribution of a newly developed synchrotron imaging technique[1] to metamorphic rocks studies. The technique allows to perform hard X-rays full-field imaging spectroscopy with high spectral and spatial resolution (Thieme, J, et al., "The sub-micron resolution X-ray spectroscopy beamline at NSLS-II", Nuclear Instruments and Methods in Physics Research Section A, 649(1), 46-48 (2011).

  14. SRX - a X-ray spectroscopy beamline with sub-100nm spatial resolution at NSLS-II

    Science.gov (United States)

    Thieme, J.

    2011-12-01

    J. Thieme, V. deAndrade, Y. Yao, J. Prietzel* (NSLS-II, Brookhaven National Laboratory, USA; *TU Munich, Germany) The new electron storage ring NSLS-II will be a source of synchrotron radiation with an unmatched low emittance. Such a facility is very well suited for hosting experiments in need of coherent radiation. One of first six beamlines to be constructed at NSLS-II will be a high resolution spectroscopy station, dedicated especially for environmental and geo-sciences. A canted setup of two undulators will serve as independent light sources for two branches of this beamline. One branch line is planned to address the energy range from 4.65 keV to 24 keV focusing the beam down to a small spot size with Kirkpatrick-Baez mirrors. The expected photon flux in the spot is in the range of above 10^13 phot/sec. A horizontally deflecting double crystal monochromator with maximum stability will ensure the possibility of spectroscopy with very high spectral resolution. The second branch is planned for reaching lower X-ray energies, addressing the range of 2 keV up to 15 keV, but with a higher spatial resolution. Using a Fresnel zoneplate, the spatial resolution aimed for is in the range of 30 nm. It can be expected that this branch would be attractive for more biological applications from environmental science due to the many elements of interest within that energy range. The experimental station will be designed to not only host X-ray fluorescence experiments but diffraction imaging experiments as well. The commissioning of this beamline will start in 2014, therefore a detailed design description will be presented here. As an example of what is achievable at this NSLS-II beamline we will present a spatially resolved study on the co-localization of iron and sulfur in a forest soil. The scientific topic to be addressed was to identify unambiguously the relationship between the speciation of iron and sulfur as a function of the chemical state of the surrounding soil when

  15. A Fast, Versatile Nanoprobe for Complex Materials: The Sub-micron Resolution X-ray Spectroscopy Beamline at NSLS-II (491st Brookhaven Lecture)

    Energy Technology Data Exchange (ETDEWEB)

    Thieme, Juergen [BNL Photon Sciences Directorate

    2014-02-06

    Time is money and for scientists who need to collect data at research facilities like Brookhaven Lab’s National Synchrotron Light Source (NSLS), “beamtime” can be a precious commodity. While scanning a complex material with a specific technique and standard equipment today would take days to complete, researchers preparing to use brighter x-rays and the new sub-micron-resolution x-ray spectroscopy (SRX) beamline at the National Synchrotron Light Source II (NSLS-II) could scan the same sample in greater detail with just a few hours of beamtime. Talk about savings and new opportunities for researchers! Users will rely on these tools for locating trace elements in contaminated soils, developing processes for nanoparticles to deliver medical treatments, and much more. Dr. Thieme explains benefits for next-generation research with spectroscopy and more intense x-rays at NSLS-II. He discusses the instrumentation, features, and uses for the new SRX beamline, highlighting its speed, adjustability, and versatility for probing samples ranging in size from millimeters down to the nanoscale. He will talk about complementary beamlines being developed for additional capabilities at NSLS-II as well.

  16. Cryogenic Field Measurement of Pr2Fe14B Undulator and Performance Enhancement Options at the NSLS-II

    Energy Technology Data Exchange (ETDEWEB)

    Tanabe, T.; Chubar, O.; Harder, David A.; Lehecka, Michael; Rank, James; Rakowsky, George; Spataro, Charles

    2009-09-27

    Short period (14.5mm) hybrid undulator arrays composed of Praseodymium Iron Boron (Pr{sub 2}Fe{sub 14}B) magnets (CR53, NEOMAX, Inc.) and vanadium permendur poles have been fabricated at Brookhaven National Laboratory. Unlike Neodymium Iron Boron (Nd{sub 2}Fe{sub 14}B) magnets which exhibit spin reorientation at temperatures below 150K, PrFeB arrays monotonically increase performance with lower operating temperature. It opens up the posibility for use in operating a cryo-permanent magnet undulator (CPMU) in the range of 40K to 60K where very efficient cryocoolers are available. Magnetic flux density profiles were measured at various temperature ranges from room temperature down to liquid helium (LHe) using the Vertical Testing Facility (VTF) at the National Snchrotron Light Source-II (NSLS-II). Temperature variations of phase error have been characterized. In addition, we examined the use of textured Dysprosium (Dy) poles to replace permendur poles to obtain further improvement in performance.

  17. Optimization of a coherent soft x-ray beamline for coherent scattering experiments at NSLS-II

    Energy Technology Data Exchange (ETDEWEB)

    Shapiro D.; Chubar, O.; Kaznatcheev, K.; Reininger, R.; Sanchez-Hanke, C.; Wang, S.

    2011-08-21

    The coherent soft x-ray and full polarization control (CSX) beamline at the National Synchrotron Light Source - II (NSLS-II) will deliver 1013 coherent photons per second in the energy range of 0.2-2 keV with a resolving power of 2000. The source, a dual elliptically polarizing undulator (EPU), and beamline optics should be optimized to deliver the highest possible coherent flux in a 10-30 {micro}m spot for use in coherent scattering experiments. Using the computer code Synchrotron Radiation Workshop (SRW), we simulate the photon source and focusing optics in order to investigate the conditions which provide the highest usable coherent intensity on the sample. In particular, we find that an intermediate phasing magnet is needed to correct for the relative phase between the two EPUs and that the optimum phase setting produces a spectrum in which the desired wavelength is slightly red-shifted thus requiring a larger aperture than originally anticipated. This setting is distinct from that which produces an on-axis spectrum similar to a single long undulator. Furthermore, partial coherence calculations, utilizing a multiple electron approach, indicate that a high degree of spatial coherence is still obtained at the sample location when such an aperture is used. The aperture size which maximizes the signal-to-noise ratio of a double-slit experiment is explored. This combination of high coherence and intensity is ideally suited for x-ray ptychography experiments which reconstruct the scattering density from micro-diffraction patterns. This technique is briefly reviewed and the effects on the image quality of proximity to the beamline focus are explored.

  18. Injection and Dump Systems

    CERN Document Server

    Bracco, C; Barnes, M J; Carlier, E; Drosdal, L N; Goddard, B; Kain, V; Meddahi, M; Mertens, V; Uythoven, J

    2012-01-01

    Performance and failures of the LHC injection and ex- traction systems are presented. In particular, a comparison with the 2010 run, lessons learnt during operation with high intensity beams and foreseen upgrades are described. UFOs, vacuum and impedance problems related to the injection and extraction equipment are analysed together with possible improvements and solutions. New implemented features, diagnostics, critical issues of XPOC and IQC applications are addressed.

  19. Piezoelectric Injection Systems

    Science.gov (United States)

    Mock, R.; Lubitz, K.

    The origin of direct injection can be doubtlessly attributed to Rudolf Diesel who used air assisted injection for fuel atomisation in his first self-ignition engine. Although it became apparent already at that time that direct injection leads to reduced specific fuel consumption compared to other methods of fuel injection, it was not used in passenger cars for the moment because of its disadvantageous noise generation as the requirements with regard to comfort were seen as more important than a reduced specific consumption.

  20. Dimethyl Ether in Diesel Fuel Injection Systems

    DEFF Research Database (Denmark)

    Sorenson, Spencer C.; Glensvig, M.; Abata, D. L.

    1998-01-01

    A study of the behaviour of DME in diesel injection systems. A discussion of the effects of compressibility of DME on compression work and wave propagation.DME spray shapes and penetration rates......A study of the behaviour of DME in diesel injection systems. A discussion of the effects of compressibility of DME on compression work and wave propagation.DME spray shapes and penetration rates...

  1. Modular injection systems for miniature engines

    Science.gov (United States)

    Cochran, Mike

    1992-07-01

    Mission requirements for Kinetic Energy Weapons will require miniaturization of current vehicle propulsion systems for future Space Defence Iniative Programs. A modular injection system (MIS) valve is presented which will decrease cost, size and weight of miniaturized storable bipropellant rocket engines and features two poppet-type propellant valve modules pneumatically linked to a pilot solenoid module. A prototype modular injection valve sized for 100lbf thrust was designed and is being tested to show lower costs, fewer moving parts and a reduction in weight and size. Results show that this valve meets objectives of one-half weight, one-half cost and one-fifth the envelopment of current production valves. Studies indicate that a cruciform configuration of four nominal 100lbf thrust engines can be controlled by four modular injection valve systems in a single housing of less than 1.0 m3. Following further development and correlation of results this concept may be scaled to control four higher thrust engines.

  2. An Innovative Needle-free Injection System: Comparison to 1 ml Standard Subcutaneous Injection.

    Science.gov (United States)

    Kojic, Nikola; Goyal, Pragun; Lou, Cheryl Hamer; Corwin, Michael J

    2017-05-01

    A needle-free delivery system may lead to improved satisfaction and compliance, as well as reduced anxiety among patients requiring frequent or ongoing injections. This report describes a first-in-man assessment comparing Portal Instruments' innovative needle-free injection system with subcutaneous injections using a 27G needle. Forty healthy volunteer participants each received a total of four injections of 1.0 mL sterile saline solution, two with a standard subcutaneous injection using a 27G needle, and two using the Portal injection system. Perception of pain was measured using a 100-mm visual analog scale (VAS). Injection site reactions were assessed at 2 min and at 20-30 min after each injection. Follow-up contact was made 24-48 h after the injections. Subject preference regarding injection type was also assessed. VAS pain scores at Portal injection sites met the criteria to be considered non-inferior to the pain reported at 27G needle injection sites (i.e., upper 95% confidence bound less than +5 mm). Based on a mixed effects model, at time 0, accounting for potential confounding variables, the adjusted difference in VAS scores indicated that Portal injections were 6.5 mm lower than the 27G needle injections (95% CI -10.5, -2.5). No clinically important adverse events were noted. Portal injections were preferred by 24 (60%) of the subjects (P = 0.0015). As an early step in the development of this new needle-free delivery system, the current study has shown that a 1.0-mL saline injection can be given with less pain reported than a standard subcutaneous injection using a 27G needle.

  3. Injection system of the minicyclotron accelerator mass spectrometer

    Institute of Scientific and Technical Information of China (English)

    LIUYonghao; LIDeming; 等

    1999-01-01

    The existing injection system of the SMCAMS(super-sensitive minicyclotron accelerator mass spectrometer)is described together with the discussion of its disadvantages exposed after having been operating for five years.which provides a basis for consideration of improvements to the injection system.An optimized injection system with an analytical magent added prior to the minicryclotron has been proposed and calculated.

  4. Injection System design for a hadron therapy Synchrotron

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jin-Quan; SONG Ming-Tao; WEI Bao-Wen

    2008-01-01

    A synchrotron is designed for tumour therapy with C6+ ions or proton.Its injector is a cyclotron, which delivers C5+or H+2 ions to the synchrotron.After comparing the methods of the single-turn injection, the multi-turn injection and the stripping injection,this paper chooses the stripping injection method.In addition,the concept design of the injection system is presented,in which the synchrotron lattice is optimized.

  5. Beam shaping element for compact fiber injection systems

    Energy Technology Data Exchange (ETDEWEB)

    Weichman, L.S.; Dickey, F.M.; Shagam, R.N.

    2000-01-05

    Injection of high power, multi-mode laser profiles into a fiber optic delivery system requires controlling a number of injection parameters to maximize throughput and minimize concerns for optical damage both at the entrance and exit faces of the fiber optic. A simple method for simultaneously achieving a compact fiber injection geometry and control of these injection parameters, independent of the input source characteristics, is provided by a refractive lenslet array and simple injection lens configuration. Design criteria together with analytical and experimental results for the refractive lenslet array and short focal length injection lens are presented. This arrangement provides a uniform spatial intensity distribution at the fiber injection plane to a large degree independent of the source mode structure, spatial profile, divergence, size, and/or alignment to the injection system. This technique has application to a number of laser systems where uniform illumination of a target or remote delivery of high peak power is desired.

  6. Tracing Injection Fluids in Engineered Geothermal Systems

    Science.gov (United States)

    Rose, P. E.; Leecaster, K.; Mella, M.; Ayling, B.; Bartl, M. H.

    2011-12-01

    The reinjection of produced fluids is crucial to the effective management of geothermal reservoirs, since it provides a mechanism for maintaining reservoir pressures while allowing for the disposal of a toxic byproduct. Tracers are essential to the proper location of injection wells since they are the only known tool for reliably characterizing the flow patterns of recirculated fluids. If injection wells are placed too close to production wells, then reinjected fluids do not have sufficient residence time to extract heat from the reservoir and premature thermal breakthrough results. If injection wells are placed too far away, then the reservoir risks unacceptable pressure loss. Several thermally stable compounds from a family of very detectable fluorescent organic compounds (the naphthalene sulfonates) were characterized and found to be effective for use as geothermal tracers. Through batch-autoclave reactions, their Arrhenius pseudo-first-order decay-rate constants were determined. An analytical method was developed that allows for the laboratory determination of concentrations in the low parts-per-trillion range. Field experiments in numerous geothermal reservoirs throughout the world have confirmed the laboratory findings. Whereas conservative tracers such as the naphthalene sulfonates are effective tools for indicating interwell flow patterns and for measuring reservoir pore volumes, 'reactive' tracers can be used to constrain fracture surface area, which is the effective area for heat extraction. This is especially important for engineered geothermal system (EGS) wells, since reactive tracers can be used to measure fracture surface area immediately after drilling and while the well stimulation equipment is still on site. The reactive properties of these tracers that can be exploited to constrain fracture surface area are reversible sorption, contrasting diffusivity, and thermal decay. Laboratory batch- and flow-reactor experiments in combination with numerical

  7. Waterflooding injectate design systems and methods

    Energy Technology Data Exchange (ETDEWEB)

    Brady, Patrick V.; Krumhansl, James L.

    2016-12-13

    A method of recovering a liquid hydrocarbon using an injectate includes recovering the liquid hydrocarbon through primary extraction. Physico-chemical data representative of electrostatic interactions between the liquid hydrocarbon and the reservoir rock are measured. At least one additive of the injectate is selected based on the physico-chemical data. The method includes recovering the liquid hydrocarbon from the reservoir rock through secondary extraction using the injectate.

  8. Aperture and Delivery Precision of the LHC Injection System

    CERN Document Server

    Goddard, B; Jeanneret, J B; Kain, V; Lamont, M; Maire, V; Mertens, V; Wenninger, J

    2004-01-01

    The main LHC injection elements in interaction regions 2 and 8 comprise the injection septa (MSI), the injection kickers (MKI), together with three families of passive protection devices (TDI, TCDD and TCLI). The apertures of the two circulating beams are detailed for these elements, together with a summary of recent design modifications. The errors in the SPS, the transfer lines and the injection system are analysed, and the expected performance of the system derived, in terms of the expected delivery precision of the injected beam.

  9. Injection system of teh SSC Medium Energy Booster

    Energy Technology Data Exchange (ETDEWEB)

    Mao, N.; Gerig, R.; McGill, J.; Brown, K.

    1994-04-01

    The Medium Energy Booster (MEB) is the third of the SSCL accelerators and the largest of the resistive magnet synchrotrons. It accelerates protons from an injection momentum of 12 GeV/c to a top momentum of 200 GeV/c. A beam injection system has been designed to inject the beam transferred from the Low Energy Booster onto the MEB closed orbit in the MEB injection insertion region. The beam is injected via a vertical bending Lambertson septum magnet and a horizontal kicker with appropriate matching and very little beam loss and emittance dilution. The beam optics of the injection system is described in this paper. The required parameters of the Lambertson septum magnet and the injection kicker are given.

  10. Operational considerations for the PSB H- Injection System

    CERN Document Server

    Weterings, W; Borburgh, J; Carli, C; Fowler, T; Goddard, B

    2010-01-01

    For the LINAC4 project the PS Booster (PSB) injection system will be upgraded. The 160 MeV Hbeam will be distributed to the 4 superimposed PSB synchrotron rings and horizontally injected by means of an H- charge-exchange system. Operational considerations for the injection system are presented, including expected beam losses from unwanted field stripping of H- and excited H0 and foil scattering, possible injection failure cases and expected stripping foil lifetimes. Loading assumptions for the internal beam dumps are discussed together with estimates of doses on various components.

  11. An optimization of injecting system in die casting

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    After many years of development, die casting technology of metallic materials has been matured. In this paper,the lower-support and its injecting system were created with commercial software. And then the simulation software FLOW3D was applied to study the flow behavior of the melt during injection filling process. Both temperature field and defect distribution were simulated. Based on these results, the better injecting system with two additional overflows was adopted.

  12. An optimization of injecting system in die casting

    Directory of Open Access Journals (Sweden)

    Wei WU

    2005-05-01

    Full Text Available After many years of development, die casting technology of metallic materials has been matured. In this paper,the lower-support and its injecting system were created with commercial software. And then the simulation software FLOW3D was applied to study the flow behavior of the melt during injection filling process. Both temperature field and defect distribution were simulated. Based on these results, the better injecting system with two additional overflows wasadopted.

  13. Variable volume combustor with pre-nozzle fuel injection system

    Energy Technology Data Exchange (ETDEWEB)

    Keener, Christopher Paul; Johnson, Thomas Edward; McConnaughhay, Johnie Franklin; Ostebee, Heath Michael

    2016-09-06

    The present application provides a combustor for use with a gas turbine engine. The combustor may include a number of fuel nozzles, a pre-nozzle fuel injection system supporting the fuel nozzles, and a linear actuator to maneuver the fuel nozzles and the pre-nozzle fuel injection system.

  14. A volumetric flow sensor for automotive injection systems

    Science.gov (United States)

    Schmid, U.; Krötz, G.; Schmitt-Landsiedel, D.

    2008-04-01

    For further optimization of the automotive power train of diesel engines, advanced combustion processes require a highly flexible injection system, provided e.g. by the common rail (CR) injection technique. In the past, the feasibility to implement injection nozzle volumetric flow sensors based on the thermo-resistive measurement principle has been demonstrated up to injection pressures of 135 MPa (1350 bar). To evaluate the transient behaviour of the system-integrated flow sensors as well as an injection amount indicator used as a reference method, hydraulic simulations on the system level are performed for a CR injection system. Experimentally determined injection timings were found to be in good agreement with calculated values, especially for the novel sensing element which is directly implemented into the hydraulic system. For the first time pressure oscillations occurring after termination of the injection pulse, predicted theoretically, could be verified directly in the nozzle. In addition, the injected amount of fuel is monitored with the highest resolution ever reported in the literature.

  15. Postoperative systemic dissemination of injected elemental mercury.

    Science.gov (United States)

    Kang, Suk-Hyung; Park, Seung Won; Moon, Kyung-Yoon

    2011-04-01

    There were only a few reports of mercury on pulmonary artery. However, there is no data on surgery related mercury dissemination. The objective of the present article is to describe one case of postoperative injected mercury dissemination. A 19-year-old man presented severe neck pain including meningeal irritation sign and abdominal pain after injection of mercury for the purpose of suicide. Radiologic study showed injected mercury in the neck involving high cervical epidural space and subcutaneous layer of abdomen. Partial hemilaminectomy and open mercury evacuation of spinal canal was performed. For the removal of abdominal subcutaneous mercury, C-arm guided needle aspiration was done. After surgery, radiologic study showed disseminated mercury in the lung, heart, skull base and low spinal canal. Neck pain and abdominal pain were improved after surgery. During 1 month after surgery, there was no symptom of mercury intoxication except increased mercury concentration of urine, blood and hair. We assumed the bone work during surgery might have caused mercury dissemination. Therefore, we recommend minimal invasive surgical technique for removal of injected mercury. If open exposures are needed, cautious surgical technique to prohibit mercury dissemination is necessary and normal barrier should be protected to prevent the migration of mercury.

  16. Influence of pre-injection control parameters on main-injection fuel quantity for an electronically controlled double-valve fuel injection system of diesel engine

    Science.gov (United States)

    Song, Enzhe; Fan, Liyun; Chen, Chao; Dong, Quan; Ma, Xiuzhen; Bai, Yun

    2013-09-01

    A simulation model of an electronically controlled two solenoid valve fuel injection system for a diesel engine is established in the AMESim environment. The accuracy of the model is validated through comparison with experimental data. The influence of pre-injection control parameters on main-injection quantity under different control modes is analyzed. In the spill control valve mode, main-injection fuel quantity decreases gradually and then reaches a stable level because of the increase in multi-injection dwell time. In the needle control valve mode, main-injection fuel quantity increases with rising multi-injection dwell time; this effect becomes more obvious at high-speed revolutions and large main-injection pulse widths. Pre-injection pulse width has no obvious influence on main-injection quantity under the two control modes; the variation in main-injection quantity is in the range of 1 mm3.

  17. Study on Software Fault Injection Based on Onboard System

    Institute of Scientific and Technical Information of China (English)

    PENGJunjie; HONGBingrong; YUANChengjun; LIAiguo; WEIZhenhua; QIAOYongqiang

    2005-01-01

    Fault injection techniques are the effective methods to evaluate the dependability and validate the fault tolerance mechanisms of computer systems. Among the different fault injection techniques, software implemented fault injection technique is regarded as one of the most promising technique for evaluation of the dependability of computer systems. In this paper, combined the advantages of software fault injection and the particularity of onboard system, a new software fault injection model, which can be used to evaluate the dependability and validate the fault tolerance mechanisms of the onboard system, is put forward. To evaluate the dependability of on boardsystem effectively, the application algorithm on how to use the model is presented. The experimental results show that using the fault injection model and algorithm put forward in this paper, not only most of low-level faults such as processor register faults, memory faults and so on can be injected, but also some high-level faults such as code faults, branch faults etc. can be injected, which can be used to evaluate the dependability of the onboard systems.

  18. Economics of water injected air screw compressor systems

    Science.gov (United States)

    Venu Madhav, K.; Kovačević, A.

    2015-08-01

    There is a growing need for compressed air free of entrained oil to be used in industry. In many cases it can be supplied by oil flooded screw compressors with multi stage filtration systems, or by oil free screw compressors. However, if water injected screw compressors can be made to operate reliably, they could be more efficient and therefore cheaper to operate. Unfortunately, to date, such machines have proved to be insufficiently reliable and not cost effective. This paper describes an investigation carried out to determine the current limitations of water injected screw compressor systems and how these could be overcome in the 15-315 kW power range and delivery pressures of 6-10 bar. Modern rotor profiles and approach to sealing and cooling allow reasonably inexpensive air end design. The prototype of the water injected screw compressor air system was built and tested for performance and reliability. The water injected compressor system was compared with the oil injected and oil free compressor systems of the equivalent size including the economic analysis based on the lifecycle costs. Based on the obtained results, it was concluded that water injected screw compressor systems could be designed to deliver clean air free of oil contamination with a better user value proposition than the oil injected or oil free screw compressor systems over the considered range of operations.

  19. Layout considerations for the PSB H- injection system

    CERN Document Server

    Aiba, M; Carli, C; Chanel, M; Fowler, A; Goddard, B; Weterings, W

    2009-01-01

    The layout of the PSB H- injection system is described, including the arguments for the geometry and the required equipment performance parameters. The longitudinal positions of the main elements are specified, together with the injected and circulating beam axes. The assumptions used in determining the geometry are listed.

  20. Screw Extruder for Pellet Injection System

    Directory of Open Access Journals (Sweden)

    Sharadkumar K. Chhantbar

    2014-05-01

    Full Text Available Solid hydrogenic pellets are used as fuel for fusion energy reactor. A technique for continuous production of solid hydrogen and its isotopes by a screw extruder is suggested for the production of an unlimited number of pellets. The idea was developed and patented by PELIN laboratories, Inc. (Canada. A Gifford McMahon cryocooler is used for the generation of solid hydrogenic fluid pellets. Requirements of the pellets is depends upon the energy to be produced by tokamak. This review paper focuses on the model for the screw extruder for solidification of hydrogen ice having high injection reliability.

  1. [Development of a novel liquid injection system].

    Science.gov (United States)

    Chen, Kai; Lv, Yong-Gui

    2009-11-01

    A liquid jet injector employs compressed gas or spring to produce a high-velocity stream to deliver liquid drug into human body through skin. There are many clinical jet injection products available, none of which is domestic. A new liquid jet injector is designed based on a comprehensive analysis of the current products. The injector consists of an ejector, trigger and a re-positioning mechanism. The jets characteristics of sample injector are tested, and the results show that the maximum exit pressure is above 15 MPa, a threshold value for penetrating into the skin.

  2. Closed-Loop Tension Control System for Injection Moulding Machine

    African Journals Online (AJOL)

    Closed-Loop Tension Control System for Injection Moulding Machine. ... Open Access DOWNLOAD FULL TEXT ... it demonstrated a new technological advancement and the theory of moulding which prevents possible spillage occurrences.

  3. CANDU 6 liquid injection shutdown system waterhammer analysis using PTRAN

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Deuk Yoon; Kim, Eun Ki; Ko, Yong Sang; Park, Byung Ho; Kim, Seok Bum [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1996-06-01

    An in-core LOCA could result in flooding of the helium header in the liquid injection shutdown system. Flooding of the helium header will result in severe pressure transients (waterhammer) in the liquid injection shutdown system when the shutdown signal is initiated. To evaluate the impact of the dynamic effects of this event, a pressure transient analysis has been performed. This analysis is performed using PTRAN, which is a computer program based on the method of characteristics. The results of this analysis are used in the stress analysis of the piping and pipe supports to ensure that the liquid injection shutdown system can withstand the pressure transient loadings. This analysis report documents the results of waterhammer analysis performed for the liquid injection shutdown system for the Wolsung nuclear power plant unit 2, 3 and 4. 4 tabs., 11 figs., 15 refs. (Author).

  4. Development of Integrated Simulation System for Plastic Injection Molding

    Institute of Scientific and Technical Information of China (English)

    CHENGXue-wen; LIDe-qun; ZHOUHua-min

    2005-01-01

    Numerical simulation of injection molding have had success in predicting the behavior of polymer melt in extremely complicated geometries. Most of the current numerical solutions are based on finite-element/finite-difference/boundary-element/volume-control methods and the surface model. This paper discusses the development of an integrated CAE system for injection molding in detail, and presents the mathematics for numerical simulation of filling, packing,cooling, stress and warpage in injection molding. The developed system named as HsCAE3D is introduced at the end.

  5. The Influence of runner system on production of injection molds

    Directory of Open Access Journals (Sweden)

    Janostik Vaclav

    2016-01-01

    Full Text Available This experimental study describes the influence of runner system on rheological properties during the injection molding process. Economic effects on the amount of production are discussed as well. Autodesk Moldflow Synergy 2016 (Moldflow was used for the study of the injection process. Three suggestions of the runner system, cold runner system, hot runner system and the combination of cold–hot runner system have been promoted. These three variants underwent the rheological and economic analysis. As a result, recommendations for the application of the runner system for the required amount of production have been suggested

  6. Closed-Loop Control of Chemical Injection Rate for a Direct Nozzle Injection System

    Directory of Open Access Journals (Sweden)

    Xiang Cai

    2016-01-01

    Full Text Available To realize site-specific and variable-rate application of agricultural pesticides, accurately metering and controlling the chemical injection rate is necessary. This study presents a prototype of a direct nozzle injection system (DNIS by which chemical concentration transport lag was greatly reduced. In this system, a rapid-reacting solenoid valve (RRV was utilized for injecting chemicals, driven by a pulse-width modulation (PWM signal at 100 Hz, so with varying pulse width the chemical injection rate could be adjusted. Meanwhile, a closed-loop control strategy, proportional-integral-derivative (PID method, was applied for metering and stabilizing the chemical injection rate. In order to measure chemical flow rates and input them into the controller as a feedback in real-time, a thermodynamic flowmeter that was independent of chemical viscosity was used. Laboratory tests were conducted to assess the performance of DNIS and PID control strategy. Due to the nonlinear input–output characteristics of the RRV, a two-phase PID control process obtained better effects as compared with single PID control strategy. Test results also indicated that the set-point chemical flow rate could be achieved within less than 4 s, and the output stability was improved compared to the case without control strategy.

  7. STRATEGY FOR DIESEL ROTARY ENGINE WITH COMMON RAIL INJECTION SYSTEM

    Institute of Scientific and Technical Information of China (English)

    WU Jinjun; HAI Jingtao; SHI Jianzhong; LI Xuesong; YANG Qing; WANG Shangyong

    2006-01-01

    A direct injection low compression ratios diesel rotary engine is designed and studied to find the appropriate application of the electronic controlled high pressure common rail injection system. Current development focuses on the applied fuel injection and ignition strategies, especially concerning the combustion configurations of injectors, ignition source, and combustion chamber. The prototype engine, equipped with Bosch common rail system and high performance electronic control unit (ECU), is designed correspondingly. Studies show that the integration of a common rail injection system and the main and pilot duel injectors configurations, assisted with glow plug ignition device and flexible ECU, represents a promising approach to improve the potential of the low compression ratios diesel rotary engine. Currently the engine can run at 6 kr · min-1 steadily and the power is about 68 kW/(4 kr · min-1).

  8. BEAM DIAGNOSTICS USING BPM SIGNALS FROM INJECTED AND STORED BEAMS IN A STORAGE RING

    Energy Technology Data Exchange (ETDEWEB)

    Wang, G.M.; Shaftan; T.; Cheng; W.X.; Fliller; R.; Heese; R.; Singh; O.; Willeke; F.

    2011-03-28

    Many modern light sources are operating in top-off injection mode or are being upgraded to top-off injection mode. The storage ring always has the stored beam and injected beam for top-off injection mode. So the BPM data is the mixture of both beam positions and the injected beam position cannot be measured directly. We propose to use dedicated wide band BPM electronics in the NSLS II storage ring to retrieve the injected beam trajectory with the singular value decomposition (SVD) method. The beam position monitor (BPM) has the capability to measure bunch-by-bunch beam position. Similar electronics can be used to measure the bunch-by-bunch beam current which is necessary to get the injection beam position. The measurement precision of current needs to be evaluated since button BPM sum signal has position dependence. The injected beam trajectory can be measured and monitored all the time without dumping the stored beam. We can adjust and optimize the injected beam trajectory to maximize the injection efficiency. We can also measure the storage ring acceptance by mapping the injected beam trajectory.

  9. Dynamic Particle Injections in the Magnetospheres of the Solar System

    Science.gov (United States)

    Mauk, B.

    2014-12-01

    The occurrence of dynamic, planetward injections of plasma and energetic particles on the nightside magnetosphere is one of the defining characteristics of magnetospheric substorms at Earth. And yet, with the exploration of the solar system with planetary probes, it has become clear that dynamic planetward injections are if fact a ubiquitous characteristic of most strongly magnetized planets; only Neptune did not reveal the signatures of such processes when visited. But, within this diversity of magnetospheric environments, it is clear that the driving forces associated with injections can be very different from those at Earth. Jupiter, for example, is known to be powered by planetary rotation rather than the solar wind. Saturn has injections that are clearly powered by rotations, but it also has nightside injections that are, at minimum, triggered by solar wind events if not powered by the solar wind. Even for those magnetospheres clearly powered by rotation, there appears to be substantial similarity between the physical processes involved with the extraterrestrial planetary injections and recent formulations of injections within Earth's near-Earth magnetotail. With a focus on comparisons between Earth, Jupiter, Saturn, Uranus and Neptune, I here review the state of understanding generally of injections within extraterrestrial planets and what the comparisons might tell us about our understanding of substorm phenomena at Earth.

  10. Optomechatronic System For Automated Intra Cytoplasmic Sperm Injection*

    Directory of Open Access Journals (Sweden)

    Shulev Assen

    2015-12-01

    Full Text Available This paper presents a complex optomechatronic system for In-Vitro Fertilization (IVF, offering almost complete automation of the Intra Cytoplasmic Sperm Injection (ICSI procedure. The compound parts and sub-systems, as well as some of the computer vision algorithms, are described below. System capabilities for ICSI have been demonstrated on infertile oocyte cells.

  11. FPGA-Based Multiprocessor System for Injection Molding Control

    Directory of Open Access Journals (Sweden)

    Roque A. Osornio-Rios

    2012-10-01

    Full Text Available The plastic industry is a very important manufacturing sector and injection molding is a widely used forming method in that industry. The contribution of this work is the development of a strategy to retrofit control of an injection molding machine based on an embedded system microprocessors sensor network on a field programmable gate array (FPGA device. Six types of embedded processors are included in the system: a smart-sensor processor, a micro fuzzy logic controller, a programmable logic controller, a system manager, an IO processor and a communication processor. Temperature, pressure and position are controlled by the proposed system and experimentation results show its feasibility and robustness. As validation of the present work, a particular sample was successfully injected.

  12. Transition duct with late injection in turbine system

    Energy Technology Data Exchange (ETDEWEB)

    LeBegue, Jeffrey Scott; Pentecost, Ronnie Ray; Flanagan, James Scott; Kim, Won -Wook; McMahan, Kevin Weston

    2015-09-15

    A system for supplying an injection fluid to a combustor is disclosed. The system includes a transition duct comprising an inlet, an outlet, and a passage extending between the inlet and the outlet and defining a longitudinal axis, a radial axis, and a tangential axis. The outlet of the transition duct is offset from the inlet along the longitudinal axis and the tangential axis. The passage defines a combustion chamber. The system further includes a tube providing fluid communication for the injection fluid to flow through the transition duct and into the combustion chamber.

  13. Characteristics of pressure wave in common rail fuel injection system of high-speed direct injection diesel engines

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Herfatmanesh

    2016-05-01

    Full Text Available The latest generation of high-pressure common rail equipment now provides diesel engines possibility to apply as many as eight separate injection pulses within the engine cycle for reducing emissions and for smoothing combustion. With these complicated injection arrangements, optimizations of operating parameters for various driving conditions are considerably difficult, particularly when integrating fuel injection parameters with other operating parameters such as exhaust gas recirculation rate and boost pressure together for evaluating calibration results. Understanding the detailed effects of fuel injection parameters upon combustion characteristics and emission formation is therefore particularly critical. In this article, the results and discussion of experimental investigations on a high-speed direct injection light-duty diesel engine test bed are presented for evaluating and analyzing the effects of main adjustable parameters of the fuel injection system on all regulated emission gases and torque performance. Main injection timing, rail pressure, pilot amount, and particularly pilot timing have been examined. The results show that optimization of each of those adjustable parameters is beneficial for emission reduction and torque improvement under different operating conditions. By exploring the variation in the interval between the pilot injection and the main injection, it is found that the pressure wave in the common rail has a significant influence on the subsequent injection. This suggests that special attentions must be paid for adjusting pilot timing or any injection interval when multi-injection is used. With analyzing the fuel amount oscillation of the subsequent injections to pilot separation, it demonstrates that the frequency of regular oscillations of the actual fuel amount or the injection pulse width with the variation in pilot separation is always the same for a specified fuel injection system, regardless of engine speed

  14. Fiber-Based, Injection-Molded Optofluidic Systems

    DEFF Research Database (Denmark)

    Matteucci, Marco; Triches, Marco; Nava, Giovanni

    2015-01-01

    We present a method to fabricate polymer optofluidic systems by means of injection molding that allow the insertion of standard optical fibers. The chip fabrication and assembly methods produce large numbers of robust optofluidic systems that can be easily assembled and disposed of, yet allow...

  15. Study of fault injection system based on software

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A software fault injection system SFIS is designed, which consists of the target system plus a fault injector, fault library, workload, data collector, and data analyzer. A serial communication mechanism is adopted to simulate the factual work environment. Then a fault model is built for single particle event, which can be denoted as FM = (FL, FT). FL stands for fault location, and FT stands for fault type. The fault model supports three temporal faults: transient, intermittent, and permanent. During the experiments implemented by SFIS,the software interruption method is adopted to inject transient faults, and step trace method is adopted to inject permanent faults into the target system. The experiment results indicate that for the injected transient code segment faults, 2.8% of them do not affect the program output, 80.1% of them are detected by the built-in error detection in the system, and 17.1% of them are not detected by fault detection mechanism. The experiment results verify the validity of the fault injection method.

  16. Safety Injection System Filling Using Dynamic Venting

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Sung Je; Kim, Wong Bae; Huh, Jin; Lee, Joo Hee; Im, In Young; Kim, Eun kee [KEPCO Engineering and Construction Company, Daejeon (Korea, Republic of)

    2015-05-15

    In the APR+, the water-level elevation of the in-containment refueling water storage tank (IRWST) is lower than the highest piping of the SIS. Since the gravity filling of water from IRWST cannot fill all SIS piping, an SIP or an SCP test line is newly provided in order to allow the dynamic venting of the SIS. NEI 09-10 Revision 1a-A has concluded that use of dynamic venting is an effective means to remove gas from local high points and traps in piping when correctly based on the dynamic flow rate, void volume, Floude number, and the system water volume. In this study, feasibility of the dynamic vent is investigated. The work presented in this study evaluates the SIS and the SCS filling using the dynamic venting which is supposed to be applied to the APR+. The main ideas are as follows; 1. Dynamic venting using SIPs for the APR+ is not appropriate on the basis of 12 inches in diameter and with the flow rate, 1,460 gpm. 2. Because the high point of the SIS and the SCS is located at the piping that the two systems are sharing, the accumulated gas at the highest point can be removed by using the SCPs, and the dimension of the new piping will be determined by its length of them and the number of elbows. The calculated results are shown in Table 2. 3. The applicability of the dynamic venting methods using the SCPs that are mentioned above should be evaluated in the aspect of the system operation after the piping arrangements are settled in the APR+. The assessments to determine the pump operation time are also required.

  17. INJECTION VOLUME CONTROL BY THERMAL WAY IN TRANSGENIC DNA MICRO-INJECTION SYSTEM

    Institute of Scientific and Technical Information of China (English)

    Zhang Ling; Zhang Yun; Yang Yimin; Chen Jinghua

    2004-01-01

    Nowdays there are several manual or half-automatic methods developed to drive the DNA micro-fluid of transgenic micro-injection and they often fail to control precisely the injection volume at picolitres level.Micro-size of the injector tip and viscosity of the DNA liquid also lead to dead area of volume control.An adequate way is presented utilizing temperature gradients to direct liquid flow in the pipette from the warmer to the cooler.Compared with the previous ones, this way is helpful in decreasing the dead area of controlling through decreasing the viscous rate of DNA liquid, which changes as the temperature varies.The DNA liquid is pushed by a sheer stress at the liquid-pipette interface, which emerges when viscous rate of the liquid changes.Preliminary experimenting results show the efficiency and convenience of this way in improving the system's characteristics.

  18. A fast injection kicker system for the Tevatron

    Energy Technology Data Exchange (ETDEWEB)

    Chris C. Jensen, Robert E. Reilly and Bruce M. Hanna

    2001-07-25

    A new proton injection kicker system is required for the Tevatron in the Run II era. The new system was designed to supply 1.25 kG-m into a magnetic aperture of 48 mm vertical x 71 mm horizontal x 5 m long with a 396 ns bunch spacing. The system was designed to be upgraded to 132 ns bunch spacing with additional pulse supplies. The system design tradeoffs needed to meet these goals is discussed. These include the system topology, the system impedance and the number of magnets. This system has been installed in the Tevatron.

  19. Injection and acceleration system of pulsed racetrack microtron

    CERN Document Server

    Ermakov, A N; Ishkhanov, B S

    2002-01-01

    Paper describes a pulsed racetrack microtron (RM) with 70 MeV beam maximal power. For this project one designed rare-earth permanent magnet base bending magnets, pattern to inject a bunched electron bean through a compact alpha-magnet and prismatic biperiodic accelerating structure (PBAS) characterized by compact transverse dimensions ensuring bar-free passing of electron beam through the first orbit. Besides, the PBAS has a high-frequency quadrupole focusing. These features facilitate essentially RM design and adjustment. Paper describes tests, technique of adjustment and of measuring of systems to inject and to accelerate a pulsed racetrack microtron

  20. The Injection Laser System on the National Ignition Facility

    Energy Technology Data Exchange (ETDEWEB)

    Bowers, M; Burkhart, S; Cohen, S; Erbert, G; Heebner, J; Hermann, M; Jedlovec, D

    2006-12-13

    The National Ignition Facility (NIF) is currently the largest and most energetic laser system in the world. The main amplifiers are driven by the Injection Laser System comprised of the master oscillators, optical preamplifiers, temporal pulse shaping and spatial beam formatting elements and injection diagnostics. Starting with two fiber oscillators separated by up to a few angstroms, the pulse is phase modulated to suppress SBS and enhance spatial smoothing, amplified, split into 48 individual fibers, and then temporally shaped by an arbitrary waveform generator. Residual amplitude modulation induced in the preamplifiers from the phase modulation is also precompensated in the fiber portion of the system before it is injected into the 48 pre-amplifier modules (PAMs). Each of the PAMs amplifies the light from the 1 nJ fiber injection up to the multi-joule level in two stages. Between the two stages the pre-pulse is suppressed by 60 dB and the beam is spatially formatted to a square aperture with precompensation for the nonuniform gain profile of the main laser. The input sensor package is used to align the output of each PAM to the main laser and acquire energy, power, and spatial profiles for all shots. The beam transport sections split the beam from each PAM into four main laser beams (with optical isolation) forming the 192 beams of the NIF. Optical, electrical, and mechanical design considerations for long term reliability and availability will be discussed.

  1. Microfluidic system with integrated microinjector for automated Drosophila embryo injection.

    Science.gov (United States)

    Delubac, Daniel; Highley, Christopher B; Witzberger-Krajcovic, Melissa; Ayoob, Joseph C; Furbee, Emily C; Minden, Jonathan S; Zappe, Stefan

    2012-11-21

    Drosophila is one of the most important model organisms in biology. Knowledge derived from the recently sequenced 12 genomes of various Drosophila species can today be combined with the results of more than 100 years of research to systematically investigate Drosophila biology at the molecular level. In order to enable automated, high-throughput manipulation of Drosophila embryos, we have developed a microfluidic system based on a Pyrex-silicon-Pyrex sandwich structure with integrated, surface-micromachined silicon nitride injector for automated injection of reagents. Our system automatically retrieves embryos from an external reservoir, separates potentially clustered embryos through a sheath flow mechanisms, passively aligns an embryo with the integrated injector through geometric constraints, and pushes the embryo onto the injector through flow drag forces. Automated detection of an embryo at injection position through an external camera triggers injection of reagents and subsequent ejection of the embryo to an external reservoir. Our technology can support automated screens based on Drosophila embryos as well as creation of transgenic Drosophila lines. Apart from Drosophila embryos, the layout of our system can be easily modified to accommodate injection of oocytes, embryos, larvae, or adults of other species and fills an important technological gap with regard to automated manipulation of multicellular organisms.

  2. CENTRAL CONVEYING & AUTO FEEDING SYSTEMS FOR AN INJECTION MOLDING SHOP

    Directory of Open Access Journals (Sweden)

    Sanjeev Kumar

    2011-08-01

    Full Text Available Nowadays injection molding is probably the most important method of Processing of consumer and industrial goods, and is performed everywhere in the world. The developing of injection molding becomes a competition from day to day. This Process now integrated with computer control make the production better in quality and Better quantity. The trends of producing a plastics product in injection molding industries are recently changing from traditional method to using the FEA analysis. For injection molding industries, time and cost is very important aspects to consider because these two aspectswill directly related to the profits at a company. The next issue toconsider, to get the best parameter for the injection molding process, plastics has been waste. Through the experiment, operator will use large amount of plastics material to get the possibly parameters to setup the machine.To produce the parts with better quality and quantity these molding defects are the major obstacles in achieving the targets with quality & quantity. Various defects like Short shot, colour streaks and low productivity rates are associated with the material mixing and feeding as molded plastics are often a blend of two or more materials. Colors (master batch and other additives are often mixed (blended with the raw plastic material prior to the molding process in molding plants. So it is very necessary to work out auto blending and auto feeding of plasticgranules to the machine hopper. This paper will cover the studyof automatic blending unit & central conveying system for plasticgranule feeding to machine & will help in optimizing the injection molding process.

  3. Aging study of boiling water reactor high pressure injection systems

    Energy Technology Data Exchange (ETDEWEB)

    Conley, D.A.; Edson, J.L.; Fineman, C.F. [Lockheed Idaho Technologies Co., Idaho Falls, ID (United States)

    1995-03-01

    The purpose of high pressure injection systems is to maintain an adequate coolant level in reactor pressure vessels, so that the fuel cladding temperature does not exceed 1,200{degrees}C (2,200{degrees}F), and to permit plant shutdown during a variety of design basis loss-of-coolant accidents. This report presents the results of a study on aging performed for high pressure injection systems of boiling water reactor plants in the United States. The purpose of the study was to identify and evaluate the effects of aging and the effectiveness of testing and maintenance in detecting and mitigating aging degradation. Guidelines from the United States Nuclear Regulatory Commission`s Nuclear Plant Aging Research Program were used in performing the aging study. Review and analysis of the failures reported in databases such as Nuclear Power Experience, Licensee Event Reports, and the Nuclear Plant Reliability Data System, along with plant-specific maintenance records databases, are included in this report to provide the information required to identify aging stressors, failure modes, and failure causes. Several probabilistic risk assessments were reviewed to identify risk-significant components in high pressure injection systems. Testing, maintenance, specific safety issues, and codes and standards are also discussed.

  4. Economics of water injected air screw compressor systems

    OpenAIRE

    Madhav, K. V.; Kovacevic, A.

    2015-01-01

    There is a growing need for compressed air free of entrained oil to be used in industry. In many cases it can be supplied by oil flooded screw compressors with multi stage filtration systems, or by oil free screw compressors. However, if water injected screw compressors can be made to operate reliably, they could be more efficient and therefore cheaper to operate. Unfortunately, to date, such machines have proved to be insufficiently reliable and not cost effective. This paper describes an in...

  5. Conceptual design for the ZEPHYR neutral-beam injection system

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, W.S.; Elischer, V.P.; Goldberg, D.A.; Hopkins, D.B.; Jacobson, V.L.; Lou, K.H.; Tanabe, J.T.

    1981-03-01

    In June 1980, the Lawrence Berkeley Laboratory began a conceptual design study for a neutral beam injection system for the ZEPHYR ignition tokamak proposed by the Max-Planck-Institut fur Plasmaphysik in Garching, Germany. The ZEPHYR project was cancelled, and the LBL design effort concluded prematurely in January 1981. This report describes the conceptual design as it existed at that time, and gives brief consideration to a schedule, but does not deal with costs.

  6. LIGHT SOURCE: Conceptual design of Hefei Advanced Light Source (HALS) injection system

    Science.gov (United States)

    Zhang, Shan-Cai; Wang, Lin; Feng, Guang-Yao; Wu, Cong-Feng; Li, Wei-Min; Xu, Hong-Liang; Liu, Zu-Ping

    2009-06-01

    The Hefei Advanced Light Source(HALS) is a super low emittance storage ring and has a very short beam life time. In order to run the ring stablely, top-up injection will be necessary. The injection system will greatly affect the quality of beam. This article first gives a physics design of the injecting system. Then the injecting system is tracked under different errors. The responses of storage beam and injecting beam are given in the article.

  7. An emergency water injection system (EWIS) for future CANDU reactors

    Energy Technology Data Exchange (ETDEWEB)

    Marques, Andre L.F. [Centro Tecnologico da Marinha em Sao Paulo (CTMSP), SP (Brazil). E-mail: momarques@uol.com.br; Todreas, Neil E.; Driscoll, Michael J. [Massachusetts Inst.of Tech., Cambridge, MA (United States). Nuclear Engineering Dept.

    2000-07-01

    This paper deals with the investigation of the feasibility and effectiveness of water injection into the annulus between the calandria tubes and the pressure tubes of CANDU reactors. The purpose is to provide an efficient decay heat removal process that avoids permanent deformation of pressure tubes severe accident conditions, such as loss of coolant accident (LOCA). The water injection may present the benefit of cost reduction and better actuation of other related safety systems. The experimental work was conducted at the Massachusetts Institute of Technology (MIT), in a setup that simulated, as close as possible, a CANDU bundle annular configuration, with heat fluxes on the order of 90 kW/m{sup 2}: the inner cylinder simulates the pressure tube and the outer tube represents the calandria tube. The experimental matrix had three dimensions: power level, annulus water level and boundary conditions. The results achieved overall heat transfer coefficients (U), which are comparable to those required (for nominal accident progression) to avoid pressure tube permanent deformation, considering current CANDU reactor data. Nonetheless, future work should be carried out to investigate the fluid dynamics such as blowdown behavior, in the peak bundle, and the system lay-out inside the containment to provide fast water injection. (author)

  8. System Study: High-Pressure Coolant Injection 1998-2014

    Energy Technology Data Exchange (ETDEWEB)

    Schroeder, John Alton [Idaho National Lab. (INL), Idaho Falls, ID (United States). Risk Assessment and Management Services Dept.

    2015-12-01

    This report presents an unreliability evaluation of the high-pressure coolant injection system (HPCI) at 25 U.S. commercial boiling water reactors. Demand, run hours, and failure data from fiscal year 1998 through 2014 for selected components were obtained from the Institute of Nuclear Power Operations (INPO) Consolidated Events Database (ICES). The unreliability results are trended for the most recent 10 year period, while yearly estimates for system unreliability are provided for the entire active period. No statistically significant increasing or decreasing trends were identified in the HPCI results.

  9. System Study: High-Pressure Safety Injection 1998–2012

    Energy Technology Data Exchange (ETDEWEB)

    T. E. Wierman

    2013-10-01

    This report presents an unreliability evaluation of the high-pressure safety injection system (HPSI) at 69 U.S. commercial nuclear power plants. Demand, run hours, and failure data from fiscal year 1998 through 2012 for selected components were obtained from the Equipment Performance and Information Exchange (EPIX). The unreliability results are trended for the most recent 10 year period while yearly estimates for system unreliability are provided for the entire active period. No statistically significant increasing or decreasing trends were identified in the HPSI results.

  10. System Study: High-Pressure Safety Injection 1998–2013

    Energy Technology Data Exchange (ETDEWEB)

    Schroeder, John Alton [Idaho National Lab. (INL), Idaho Falls, ID (United States). Risk Assessment and Management Services Dept.

    2015-02-01

    This report presents an unreliability evaluation of the high-pressure safety injection system (HPSI) at 69 U.S. commercial nuclear power plants. Demand, run hours, and failure data from fiscal year 1998 through 2013 for selected components were obtained from the Institute of Nuclear Power Operations (INPO) Consolidated Events Database (ICES). The unreliability results are trended for the most recent 10-year period while yearly estimates for system unreliability are provided for the entire active period. No statistically significant increasing or decreasing trends were identified in the HPSI results.

  11. System Study: High-Pressure Coolant Injection 1998–2013

    Energy Technology Data Exchange (ETDEWEB)

    Schroeder, John Alton [Idaho National Lab. (INL), Idaho Falls, ID (United States). Risk Assessment and Management Services Dept.

    2015-01-31

    This report presents an unreliability evaluation of the high-pressure coolant injection system (HPCI) at 25 U.S. commercial boiling water reactors. Demand, run hours, and failure data from fiscal year 1998 through 2013 for selected components were obtained from the Institute of Nuclear Power Operations (INPO) Consolidated Events Database (ICES). The unreliability results are trended for the most recent 10-year period, while yearly estimates for system unreliability are provided for the entire active period. No statistically significant increasing or decreasing trends were identified in the HPCI results.

  12. System Study: High-Pressure Safety Injection 1998-2014

    Energy Technology Data Exchange (ETDEWEB)

    Schroeder, John Alton [Idaho National Lab. (INL), Idaho Falls, ID (United States). Risk Assessment and Management Services Dept.

    2015-12-01

    This report presents an unreliability evaluation of the high-pressure safety injection system (HPSI) at 69 U.S. commercial nuclear power plants. Demand, run hours, and failure data from fiscal year 1998 through 2014 for selected components were obtained from the Institute of Nuclear Power Operations (INPO) Consolidated Events Database (ICES). The unreliability results are trended for the most recent 10 year period, while yearly estimates for system unreliability are provided for the entire active period. No statistically significant increasing or decreasing trends were identified in the HPSI results.

  13. Active ultrasound pattern injection system (AUSPIS for interventional tool guidance.

    Directory of Open Access Journals (Sweden)

    Xiaoyu Guo

    Full Text Available Accurate tool tracking is a crucial task that directly affects the safety and effectiveness of many interventional medical procedures. Compared to CT and MRI, ultrasound-based tool tracking has many advantages, including low cost, safety, mobility and ease of use. However, surgical tools are poorly visualized in conventional ultrasound images, thus preventing effective tool tracking and guidance. Existing tracking methods have not yet provided a solution that effectively solves the tool visualization and mid-plane localization accuracy problem and fully meets the clinical requirements. In this paper, we present an active ultrasound tracking and guiding system for interventional tools. The main principle of this system is to establish a bi-directional ultrasound communication between the interventional tool and US imaging machine within the tissue. This method enables the interventional tool to generate an active ultrasound field over the original imaging ultrasound signals. By controlling the timing and amplitude of the active ultrasound field, a virtual pattern can be directly injected into the US machine B mode display. In this work, we introduce the time and frequency modulation, mid-plane detection, and arbitrary pattern injection methods. The implementation of these methods further improves the target visualization and guiding accuracy, and expands the system application beyond simple tool tracking. We performed ex vitro and in vivo experiments, showing significant improvements of tool visualization and accurate localization using different US imaging platforms. An ultrasound image mid-plane detection accuracy of ±0.3 mm and a detectable tissue depth over 8.5 cm was achieved in the experiment. The system performance is tested under different configurations and system parameters. We also report the first experiment of arbitrary pattern injection to the B mode image and its application in accurate tool tracking.

  14. Use of liposomes as injectable-drug delivery systems.

    Science.gov (United States)

    Ostro, M J; Cullis, P R

    1989-08-01

    The formation of liposomes and their application as delivery systems for injectable drugs are described. Liposomes are microscopic vesicles composed of one or more lipid membranes surrounding discrete aqueous compartments. These vesicles can encapsulate water-soluble drugs in their aqueous spaces and lipid-soluble drugs within the membrane itself. Liposomes release their contents by interacting with cells in one of four ways: adsorption, endocytosis, lipid exchange, or fusion. Liposome-entrapped drugs are distributed within the body much differently than free drugs; when administered intravenously to healthy animals and humans, most of the injected vesicles accumulate in the liver, spleen, lungs, bone marrow, and lymph nodes. Liposomes also accumulate preferentially at the sites of inflammation and infection and in some solid tumors; however, the reason for this accumulation is not clear. Four major factors influence liposomes' in vivo behavior and biodistribution: (1) liposomes tend to leak if cholesterol is not included in the vesicle membrane, (2) small liposomes are cleared more slowly than large liposomes, (3) the half-life of a liposome increases as the lipid dose increases, and (4) charged liposomal systems are cleared more rapidly than uncharged systems. The most advanced application of liposome-based therapy is in the treatment of systemic fungal infections, especially with amphotericin B. Liposomes are also under investigation for treatment of neoplastic disorders. Liposomes' uses in cancer therapy include encapsulation of known antineoplastic agents such as doxorubicin and methotrexate, delivery of immune modulators such as N-acetylmuramyl-L-alanine-D-isoglutamine, and encapsulation of new chemical entities that are synthesized with lipophilic segments tailored for insertion into lipid bilayers. Liposomal formulations of injectable antimicrobial agents and antineoplastic agents already are undergoing clinical testing, and most probably will receive

  15. Active ultrasound pattern injection system (AUSPIS) for interventional tool guidance.

    Science.gov (United States)

    Guo, Xiaoyu; Kang, Hyun-Jae; Etienne-Cummings, Ralph; Boctor, Emad M

    2014-01-01

    Accurate tool tracking is a crucial task that directly affects the safety and effectiveness of many interventional medical procedures. Compared to CT and MRI, ultrasound-based tool tracking has many advantages, including low cost, safety, mobility and ease of use. However, surgical tools are poorly visualized in conventional ultrasound images, thus preventing effective tool tracking and guidance. Existing tracking methods have not yet provided a solution that effectively solves the tool visualization and mid-plane localization accuracy problem and fully meets the clinical requirements. In this paper, we present an active ultrasound tracking and guiding system for interventional tools. The main principle of this system is to establish a bi-directional ultrasound communication between the interventional tool and US imaging machine within the tissue. This method enables the interventional tool to generate an active ultrasound field over the original imaging ultrasound signals. By controlling the timing and amplitude of the active ultrasound field, a virtual pattern can be directly injected into the US machine B mode display. In this work, we introduce the time and frequency modulation, mid-plane detection, and arbitrary pattern injection methods. The implementation of these methods further improves the target visualization and guiding accuracy, and expands the system application beyond simple tool tracking. We performed ex vitro and in vivo experiments, showing significant improvements of tool visualization and accurate localization using different US imaging platforms. An ultrasound image mid-plane detection accuracy of ±0.3 mm and a detectable tissue depth over 8.5 cm was achieved in the experiment. The system performance is tested under different configurations and system parameters. We also report the first experiment of arbitrary pattern injection to the B mode image and its application in accurate tool tracking.

  16. Methodology for surge pressure evaluation in a water injection system

    Energy Technology Data Exchange (ETDEWEB)

    Meliande, Patricia; Nascimento, Elson A. [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Dept. de Engenharia Civil; Mascarenhas, Flavio C.B. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Lab. de Hidraulica Computacional; Dandoulakis, Joao P. [SHELL of Brazil, Rio de Janeiro, RJ (Brazil)

    2009-07-01

    Predicting transient effects, known as surge pressures, is of high importance for offshore industry. It involves detailed computer modeling that attempts to simulate the complex interaction between flow line and fluid in order to ensure efficient system integrity. Platform process operators normally raise concerns whether the water injection system is adequately designed or not to be protected against possible surge pressures during sudden valve closure. This report aims to evaluate the surge pressures in Bijupira and Salema water injection systems due to valve closure, through a computer model simulation. Comparisons among the results from empirical formulations are discussed and supplementary analysis for Salema system were performed in order to define the maximum volumetric flow rate for which the design pressure was able to withstand. Maximum surge pressure values of 287.76 bar and 318.58 bar, obtained in Salema and Bijupira respectively, using empirical formulations have surpassed the operating pressure design, while the computer model results have pointed the greatest surge pressure value of 282 bar in Salema system. (author)

  17. Strontium-rich injectable hybrid system for bone regeneration

    Energy Technology Data Exchange (ETDEWEB)

    Neves, Nuno, E-mail: nsmneves@gmail.com [Instituto de Investigação e Inovação em Saúde, Universidade do Porto (Portugal); INEB — Instituto de Engenharia Biomédica, Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto (Portugal); FMUP — Faculdade de Medicina da Universidade do Porto, Departamento de Cirurgia, Serviço de Ortopedia, Alameda Prof. Hernâni Monteiro, 4200-319 Porto (Portugal); Campos, Bruno B. [FCUP — Faculdade de Ciências da Universidade do Porto, Centro de Investigação em Química, Departamento de Química e Bioquímica, Rua do Campo Alegre 1021/1055, 4169-007 Porto (Portugal); Almeida, Isabel F.; Costa, Paulo C. [FFUP — Faculdade de Farmácia da Universidade do Porto, Laboratório de Tecnologia Farmacêutica, Departamento de Ciências do Medicamento, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto (Portugal); Cabral, Abel Trigo [FMUP — Faculdade de Medicina da Universidade do Porto, Departamento de Cirurgia, Serviço de Ortopedia, Alameda Prof. Hernâni Monteiro, 4200-319 Porto (Portugal); and others

    2016-02-01

    Current challenges in the development of scaffolds for bone regeneration include the engineering of materials that can withstand normal dynamic physiological mechanical stresses exerted on the bone and provide a matrix capable of supporting cell migration and tissue ingrowth. The objective of the present work was to develop and characterize a hybrid polymer–ceramic injectable system that consists of an alginate matrix crosslinked in situ in the presence of strontium (Sr), incorporating a ceramic reinforcement in the form of Sr-rich microspheres. The incorporation of Sr in the microspheres and in the vehicle relies on the growing evidence that Sr has beneficial effects in bone remodeling and in the treatment of osteopenic disorders and osteoporosis. Sr-rich porous hydroxyapatite microspheres with a uniform size and a mean diameter of 555 μm were prepared, and their compression strength and friability tested. A 3.5% (w/v) ultrapure sodium alginate solution was used as the vehicle and its in situ gelation was promoted by the addition of calcium (Ca) or Sr carbonate and Glucone-δ-lactone. Gelation times varied with temperature and crosslinking agent, being slower for Sr than for Ca, but adequate for injection in both cases. Injectability was evaluated using a device employed in vertebroplasty surgical procedures, coupled to a texture analyzer in compression mode. Compositions with 35% w of microspheres presented the best compromise between injectability and compression strength of the system, the force required to extrude it being lower than 100 N. Micro CT analysis revealed a homogeneous distribution of the microspheres inside the vehicle, and a mean inter-microspheres space of 220 μm. DMA results showed that elastic behavior of the hybrid is dominant over the viscous one and that the higher storage modulus was obtained for the 3.5%Alg–35%Sr-HAp-Sr formulation. - Highlights: • We developed a Sr rich viscoelastic hybrid system (alginate matrix crosslinked in

  18. Control System of Neutral Beam Injection on HT-7

    Institute of Scientific and Technical Information of China (English)

    Wang Yongjun; Hu Chundong; Liu Zhimin; Liu Sheng; Song Shihua; Yang Daoye

    2005-01-01

    Neutral Beam Injection control system (NBICS) is constructed to measure the plasma current, Magnet current, vacuum pressure, cryopump temperature, control water cooling, filament voltage, and power supply, etc. The NBICS, consisting mainly of a Programmable Logic Controller (PLC) subsystem, data acquisition and processing subsystem and cryopump and vacuum pressure monitoring subsystem, has successfully been used on a NBI device. In this article, the design of NBICS on HT-7 is discussed and each subsystem is described in particular.In addition, some experimental results are reported which are very important data for further research related to the HT-7 tokamak.

  19. Injection system for microtron-based terehertz FEL

    Energy Technology Data Exchange (ETDEWEB)

    Kazakevich, Grigory M.; Kuznetsov, Gennady I.; Pavlov, Viatcheslav M.; /Novosibirsk, IYF; Jeong, Young Uk; Park, Seong Hee; Lee, Byung Cheol; /KAERI, Taejon

    2005-09-01

    A reliable injection system of the widely tunable microtron-based terahertz Free Electron Laser (FEL) has been developed and during last few years provides stable operation of the FEL for users. The system is based on the long-life thermionic cathode assembly using 2.5 mm-in diameter monocrystalline LaB{sub 6} emitter, heated by the tungsten cylindrical filament with the power consumption less than 55 W. The cathode emits the macro-pulse current in the range of 1-1.4 A providing operation of the terahertz FEL during more than 1000 h. The cathode assembly is installed on the cover of the I-type microtron accelerating cavity in location providing an efficient injection for the acceleration with variable number of orbits. This variation widely changes the energy of the electron beam and allows on-the-fly retuning of the FEL in the range of 1-3 THz. Pulse-signal system stabilizing the emission current prevents randomized break-downs in the accelerating cavity and decreases fluctuations of the power of the FEL radiation. The standard deviation of the fluctuations was measured to be less than 10% during long-time operation.

  20. Injection System for Microtron-Based Terahertz FEL

    CERN Document Server

    Kazakevich, G M

    2005-01-01

    A reliable injection system of the widely tunable microtron-based terahertz Free Electron Laser (FEL) has been developed and during last few years provides stable operation of the FEL for users. The system is based on the long-life thermionic cathode assembly using 2.5 mm-in diameter monocrystalline LaB6 emitter, heated by the tungsten cylindrical filament with the power consumption less than 50 W. The cathode emits the macro-pulse current in the range of 1-1.4 A providing operation of the terahertz FEL during more than 1000 h. The cathode assembly is installed on the cover of the I-type microtron accelerating cavity in location providing an efficient injection for the acceleration with variable number of orbits. This variation widely changes the energy of the electron beam and allows on-the-fly retuning of the FEL in the range of 1-3 THz. Pulse-signal system stabilizing the emission current prevents randomized break-downs in the accelerating cavity and decreases macro-pulse power fluctuations of the FEL radi...

  1. Linearisation via input-output injection of time delay systems

    Science.gov (United States)

    García-Ramírez, Eduardo; Moog, Claude H.; Califano, Claudia; Alejandro Márquez-Martínez, Luis

    2016-06-01

    This paper deals with the problem of linearisation of systems with constant commensurable delays by input-output injection using algebraic control tools based on the theory of non-commutative rings. Solutions for the problem of linearisation free of delays, and with delays of an observable nonlinear time-delay systems are presented based on the analysis of the input-output equation. These results are achieved by means of constructive algorithms that use the nth derivative of the output expressed in terms of the state-space variables instead of the explicit computation of the input-output representation of the system. Necessary and sufficient conditions are established in both cases by means of an invertible change of coordinates.

  2. Control of Surge in Centrifugal Compressor by Using a Nozzle Injection System: Universality in Optimal Position of Injection Nozzle

    Directory of Open Access Journals (Sweden)

    Toshiyuki Hirano

    2012-01-01

    Full Text Available The passive control method for surge and rotating stall in centrifugal compressors by using a nozzle injection system was proposed to extend the stable operating range to the low flow rate. A part of the flow at the scroll outlet of a compressor was recirculated to an injection nozzle installed on the inner wall of the suction pipe of the compressor through the bypass pipe and injected to the impeller inlet. Two types of compressors were tested at the rotational speeds of 50,000 rpm and 60,000 rpm with the parameter of the circumferential position of the injection nozzle. The present experimental results revealed that the optimum circumferential position, which most effectively reduced the flow rate for the surge inception, existed at the opposite side of the tongue of the scroll against the rotational axis and did not depend on the compressor system and the rotational speeds.

  3. Microcontroller-driven fluid-injection system for atomic force microscopy.

    Science.gov (United States)

    Kasas, S; Alonso, L; Jacquet, P; Adamcik, J; Haeberli, C; Dietler, G

    2010-01-01

    We present a programmable microcontroller-driven injection system for the exchange of imaging medium during atomic force microscopy. Using this low-noise system, high-resolution imaging can be performed during this process of injection without disturbance. This latter circumstance was exemplified by the online imaging of conformational changes in DNA molecules during the injection of anticancer drug into the fluid chamber.

  4. Multiple dopant injection system for small rocket engines

    Science.gov (United States)

    Sakala, G. G.; Raines, N. G.

    1992-07-01

    The Diagnostics Test Facility (DTF) at NASA's Stennis Space Center (SSC) was designed and built to provide a standard rocket engine exhaust plume for use in the research and development of engine health monitoring instrumentation. A 1000 lb thrust class liquid oxygen (LOX)-gaseous hydrogen (GH2) fueled rocket engine is used as the subscale plume source to simulate the SSME during experimentation and instrument development. The ability of the DTF to provide efficient, and low cost test operations makes it uniquely suited for plume diagnostic experimentation. The most unique feature of the DTF is the Multiple Dopant Injection System (MDIS) that is used to seed the exhaust plume with the desired element or metal alloy. The dopant injection takes place at the fuel injector, yielding a very uniform and homogeneous distribution of the seeding material in the exhaust plume. The MDIS allows during a single test firing of the DTF, the seeding of the exhaust plume with up to three different dopants and also provides distilled water base lines between the dopants. A number of plume diagnostic-related experiments have already utilized the unique capabilities of the DTF.

  5. New ion source for KSTAR neutral beam injection system.

    Science.gov (United States)

    Kim, Tae-Seong; Jeong, Seung Ho; In, Sang-Ryul

    2012-02-01

    The neutral beam injection system (NBI-1) of the KSTAR tokamak can accommodate three ion sources; however, it is currently equipped with only one prototype ion source. In the 2010 and 2011 KSTAR campaigns, this ion source supplied deuterium neutral beam power of 0.7-1.6 MW to the KSTAR plasma with a beam energy of 70-100 keV. A new ion source will be prepared for the 2012 KSTAR campaign with a much advanced performance compared with the previous one. The newly designed ion source has a very large transparency (∼56%) without deteriorating the beam optics, which is designed to deliver a 2 MW injection power of deuterium beams at 100 keV. The plasma generator of the ion source is of a horizontally cusped bucket type, and the whole inner wall, except the cathode filaments and plasma grid side, functions as an anode. The accelerator assembly consists of four multi-circular aperture grids made of copper and four electrode flanges made of aluminum alloy. The electrodes are insulated using PEEK. The ion source will be completed and tested in 2011.

  6. Embedded computer controlled premixing inline injection system for air-assisted variable-rate sprayers

    Science.gov (United States)

    Improvements to reduce chemical waste and environmental pollution for variable-rate sprayers used in orchards and ornamental nurseries require inline injection techniques. A microprocessor controlled premixing inline injection system implementing a ceramic piston chemical metering pump and two small...

  7. Continuously acting fuel injection system. Kontinuierlich arbeitende Kraftstoffeinspritzanlage

    Energy Technology Data Exchange (ETDEWEB)

    Dorsch, H.; Hofbauer, A.; Steinbeck, H.

    1986-02-20

    A continuously acting fuel injection system with an air quantity meter in the suction pipe and a fuel distributor controlled by it is provided with an additional device for use in a multi-cylinder aircraft engine, which is used to give the best possible performance, fuel saving and safety. An altitude control pressure controller is connected in parallel with a warming up controller to the control pressure pipe going to the fuel distributor, which measures the control pressure and therefore the fuel dosing according to the air density varying with the temperature and pressure. By fitting a fixed throttle between the control pressure pipe and the fuel return pipe to the fuel tank, emergency running of the engine is ensured on failure of both controllers. (orig./BWI).

  8. Propellant Feed System for Swirl-Coaxial Injection

    Science.gov (United States)

    Reynolds, David Christopher (Inventor)

    2015-01-01

    A propellant feed system for swirl-coaxial injection of a liquid propellant includes a reservoir having a bottom plate and at least one tube originating in the bottom plate and extending therefrom. The tube has rectangular slits defined in and distributed tangentially and evenly about a portion of the tube that is disposed in the bottom plate. Drain holes are provided in the bottom plate and tunnels are defined in the bottom plate. Each tunnel fluidly couples one of the drain holes to a corresponding one of the rectangular slits. Each tunnel includes (i) a bend of at least 90.degree., and (ii) a straight portion leading to its corresponding rectangular slit wherein the straight portion is at least five times as long as a hydraulic diameter of the corresponding rectangular slit.

  9. Performance of the RHIC Injection Line Instrumentation Systems

    Science.gov (United States)

    Shea, T. J.; Witkover, R. L.; Cameron, P.; Connolly, R.; Ryan, W. A.; Smith, G.; Zitvogel, E.

    1997-05-01

    The beam injection line from the Alternating Gradient Synchrotron (AGS) to the Relativistic Heavy Ion Collider (RHIC) transports proton and heavy ion bunches. This line and the RHIC first sextant currently contain thefollowing complement of beam instrumentation: stripline position monitors, ionization loss monitors, video profile monitors, and commercial current transformers. Over several years, these systems have been designed and bench tested to assure a desired performance level. The design criteria will be briefly reviewed. Then, using data from laboratory tests and the recent single pass beam tests, desired performance and attained performance will be compared. Finally, experience from the beam based tests will be applied to the design criteria for the future collider ring instrumentation.

  10. Vacuum systems of linear accelerators of the NICA injection complex

    Science.gov (United States)

    Kosachev, V. V.; Bazanov, A. M.; Butenko, A. V.; Galimov, A. R.; Nesterov, A. V.; Pivin, R. V.; Smirnov, A. V.

    2016-12-01

    The NICA project, which includes several accelerators of charged particles, is under construction in the Laboratory of High Energy Physics, Joint Institute for Nuclear Research (JINR), Dubna. Obtaining the required vacuum conditions is one of the key points in implementing the project, because reaching the required ion lifetime at all stages of particle acceleration is what determines the effective luminosity of the experiments in the long run. Currently, modernization of the vacuum system of the injection complex of the LU-20 linear accelerator of light ions, one of oldest accelerators in the JINR, is being carried out and the new HILAC linear accelerator for the acceleration of gold ions in the collider mode of the NICA complex is being installed. At the end parts of the linear accelerators, the residual gas pressure must be approximately 10-5 Pa, which is determined by the maximum amplitude of the RF electric field used for the acceleration of ions.

  11. Clinical Application of the Sapphire Unfolder Lens Injection System

    Institute of Scientific and Technical Information of China (English)

    Weiai Guo; Danying Zheng; Zhenyu Li; Yiyong Qian; Zhenping Zhang

    2002-01-01

    Purpose: To summarize the clinical experience of 300 cases using the Sapphire unfloder intraocular lens (IOL) injection system.Methods: After the standard phacoemulsification, an AR40e IOL was implanted using the Sapphire Unfolder. The involved problems during and after the operation were observed and analyzed.Results:The complications occurred during the operation including the crack at the haptic-optic junction in 2 cases, slight kink in the haptic in 5 cases, IOL clamp into the cartridge in 2 cases, posterior capsular rupture in 2 cases and endothelium damage in the central small area in 4 cases. All the patients recovered successfully with IOLs in good position.Conclusion: IOL implantation with the Sapphire Unfolder led to no serious complications and got the satisfactory results.

  12. Experimental investigations of a single cylinder genset engine with common rail fuel injection system

    Directory of Open Access Journals (Sweden)

    Gupta Paras

    2014-01-01

    Full Text Available Performance and emissions characteristics of compression ignition (CI engines are strongly dependent on quality of fuel injection. In an attempt to improve engine combustion, engine performance and reduce the exhaust emissions from a single cylinder constant speed genset engine, a common rail direct injection (CRDI fuel injection system was deployed and its injection timings were optimized. Results showed that 34°CA BTDC start of injection (SOI timings result in lowest brake specific fuel consumption (BSFC and smoke opacity. Advanced injection timings showed higher cylinder peak pressure, pressure rise rate, and heat release rate due to relatively longer ignition delay experienced.

  13. Continuous, pulsed and stopped flow in a u-flow injection system (numerical vs experimental)

    NARCIS (Netherlands)

    van Akker, E.B.; Bos, M.; van der Linden, W.E.

    1999-01-01

    The effects of continuous, pulsed and stopped flow on the dispersion of a sample injected into a μ-flow injection system were studied. A channel with a volume of 1 μl was used to compare experimental results with numerical results. The injection was 0.067 μl of bromocresolgreen solution into a borax

  14. Continuous, pulsed and stopped flow in a μ-flow injection system (numerical vs experimental)

    NARCIS (Netherlands)

    Akker, van E.B.; Bos, M.; Linden, van der W.E.

    1999-01-01

    The effects of continuous, pulsed and stopped flow on the dispersion of a sample injected into a μ-flow injection system were studied. A channel with a volume of 1 μl was used to compare experimental results with numerical results. The injection was 0.067 μl of bromocresolgreen solution into a borax

  15. Flow Injection/Sequential Injection Analysis Systems: Potential Use as Tools for Rapid Liver Diseases Biomarker Study

    Directory of Open Access Journals (Sweden)

    Supaporn Kradtap Hartwell

    2012-01-01

    Full Text Available Flow injection/sequential injection analysis (FIA/SIA systems are suitable for carrying out automatic wet chemical/biochemical reactions with reduced volume and time consumption. Various parts of the system such as pump, valve, and reactor may be built or adapted from available materials. Therefore the systems can be at lower cost as compared to other instrumentation-based analysis systems. Their applications for determination of biomarkers for liver diseases have been demonstrated in various formats of operation but only a few and limited types of biomarkers have been used as model analytes. This paper summarizes these applications for different types of reactions as a guide for using flow-based systems in more biomarker and/or multibiomarker studies.

  16. Experiments on Plasma Injection into a Centrifugally Confined System

    Science.gov (United States)

    Messer, S.; Bomgardner, R.; Brockington, S.; Case, A.; Witherspoon, F. D.; Uzun-Kaymak, I.; Elton, R.; Young, W.; Teodorescu, C.; Morales, C. H.; Ellis, R. F.

    2009-11-01

    We describe the cross-field injection of plasma into a centrifugally-confined system. Two different types of plasma railgun have been installed on the Maryland Centrifugal Experiment (MCX) in an attempt to drive that plasma's rotation. The initial gun was a coaxial device designed to mitigate the blowby instability. The second one was a MiniRailgun with a rectangular bore oriented so that the MCX magnetic field augments the railgun's internal magnetic field. Tests at HyperV indicate this MiniRailgun reaches much higher densities than the original gun, although muzzle velocity is slightly reduced. We discuss the impact of these guns on MCX for various conditions. Initial results show that even for a 2 kG field, firing the MiniRailgun modifies oscillations of the MCX diamagnetic loops and can impact the core current and voltage. The gun also has a noticeable impact on MCX microwave emissions. These observations suggest plasma enters the MCX system. We also compare diagnostic data collected separately from MCX for these and other guns, focussing primarily on magnetic measurements.

  17. Injection molding lens metrology using software configurable optical test system

    Science.gov (United States)

    Zhan, Cheng; Cheng, Dewen; Wang, Shanshan; Wang, Yongtian

    2016-10-01

    Optical plastic lens produced by injection molding machine possesses numerous advantages of light quality, impact resistance, low cost, etc. The measuring methods in the optical shop are mainly interferometry, profile meter. However, these instruments are not only expensive, but also difficult to alignment. The software configurable optical test system (SCOTS) is based on the geometry of the fringe refection and phase measuring deflectometry method (PMD), which can be used to measure large diameter mirror, aspheric and freeform surface rapidly, robustly, and accurately. In addition to the conventional phase shifting method, we propose another data collection method called as dots matrix projection. We also use the Zernike polynomials to correct the camera distortion. This polynomials fitting mapping distortion method has not only simple operation, but also high conversion precision. We simulate this test system to measure the concave surface using CODE V and MATLAB. The simulation results show that the dots matrix projection method has high accuracy and SCOTS has important significance for on-line detection in optical shop.

  18. The new control system of the SPS injection kicker

    CERN Document Server

    Antoine, A; Marchand, A; Verhagen, H

    2002-01-01

    The SPS accelerator will be used as injector for the LHC and has to be adapted to the LHC requirements. The tight specification on beam blow-up and bunch spacing in the SPS has required an upgrade program of the SPS injection kicker in order to obtain a reduction of the magnetic field ripple to less than ± 0.5% and of the magnet current rise time to less than 145 ns. In this context, the slow control part has been entirely rebuilt on the basis of off-the-shelf industrial components. A hierarchical architecture based on a SIEMENS S7-400 master programmable logic controller interconnected through PROFIBUS-DP to S7-300 deported and decentralised I/Os has been implemented. Integration of in-house specific G-64 hardware systems inside this industrial environment has been done through a PROFIBUS-DP to G-64 intelligent interface based on an OEM fieldbus mezzanine board on one side and an FPGA implementing the required functionality on the other. Simultaneously, the fast timing system has been completely reshuffled ...

  19. The Expected Performance of the LHC Injection Protection System

    CERN Document Server

    Kain, V; Ducimetière, L; Goddard, B; Lamont, M; Mertens, V

    2004-01-01

    The passive protection devices TDI, TCDD and TCLI are required to prevent damage to the LHC in case of serious injection failures, in particular of the MKI injection kicker. A detailed particle tracking, taking realistic mechanical, positioning, injection, closed orbit and local optical errors into account, has been used to determine the required settings of the absorber elements to guarantee protection against different MKI failure modes. The expected protection level of the combination of TDI with TCLI, with the new TCLI layout, is presented. Conclusions are drawn concerning the expected damage risk level.

  20. Blower Gun pellet injection system for W7-X

    Energy Technology Data Exchange (ETDEWEB)

    Dibon, M., E-mail: mathias.dibon@ipp.mpg.de [Max-Planck-Institute for Plasma Physics, Boltzmannstr. 2, 85748 Garching (Germany); Baldzuhn, J.; Beck, M. [Max-Planck-Institute for Plasma Physics, Boltzmannstr. 2, 85748 Garching (Germany); Cardella, A. [Lehrstuhl für Nukleartechnik, TU Munich, Boltzmannstr. 15, 85748 Garching (Germany); Köchl, F. [Atominstitut, TU Wien, 1020 Vienna (Austria); Kocsis, G. [Wigner RCP, RMI, P.O. Box 49, H-1525 Budapest-114 (Hungary); Lang, P.T. [Max-Planck-Institute for Plasma Physics, Boltzmannstr. 2, 85748 Garching (Germany); Macian-Juan, R. [Lehrstuhl für Nukleartechnik, TU Munich, Boltzmannstr. 15, 85748 Garching (Germany); Ploeckl, B. [Max-Planck-Institute for Plasma Physics, Boltzmannstr. 2, 85748 Garching (Germany); Szepesi, T. [Wigner RCP, RMI, P.O. Box 49, H-1525 Budapest-114 (Hungary); Weisbart, W. [Max-Planck-Institute for Plasma Physics, Boltzmannstr. 2, 85748 Garching (Germany)

    2015-10-15

    Highlights: • Operational principle of the ASDEX Upgrade Blower Gun. • Guiding tube properties for pellet guiding according to the requirements of W7-X. • Diagnostics for the characterization of the injection system. • Experimental procedure to investigate the performance of the Blower Gun. • Results concerning pellet speeds, mass loss, delivery efficiency and exit angle. - Abstract: Foreseen to perform pellet investigations in the new stellarator W7-X, the former ASDEX Upgrade Blower Gun was revised and revitalized. The systems operational characteristics have been surveyed in a test bed. The gun is designed to launch cylindrical pellets with 2 mm diameter and 2 mm length, produced from frozen deuterium D{sub 2}, hydrogen H{sub 2} or a gas mixture consisting of 50% H{sub 2} and 50% D{sub 2}. Pellets are accelerated by a short pulse of pressurized helium propellant gas to velocities in the range of 100–250 m/s. Delivery reliabilities at the launcher exit reach almost unity. The initial pellet mass is reduced to about 50% during the acceleration process. Pellet transfer to the plasma vessel was investigated by a first mock up guiding tube version. Transfer through this S-shaped stainless steel guiding tube (inner diameter 8 mm; length 6 m) containing two 1 m curvature radii was investigated for all pellet types. Tests were performed applying repetition rates from 2 Hz to 50 Hz and propellant gas pressures ranging from 0.1 to 0.6 MPa. For both H{sub 2} and D{sub 2}, low overall delivery efficiencies were observed at slow repetition rates, but stable efficiencies of about 90% above 10 Hz. About 10% of the mass is eroded while flying through the guiding tube. Pellets exit the guiding tube with an angular spread of less than 14°.

  1. Central Nervous System Toxicity After Botulinum Neurotoxin Injection

    Science.gov (United States)

    Ilkhchoui, Yashar; Ghaly, Ramsis F.; Knezevic, N. Nick; Candido, Kenneth D

    2013-01-01

    Since Its first description of botulism toxicity in 1820s, specific formulations of botulinum neurotoxin (BoNT) have been introduced with different clinical benefits. However, there is increasing number of adverse events reported to Food and Drug Administration. This report presents the case of 62-year-old woman with Parkinson’s disease who received BoNT injections to treat painful spasticity in her hands. She developed severe generalized dystonia shortly after BoNT injections. PMID:24223367

  2. Micro Injection Molding of Thin Walled Geometries with Induction Heating System

    DEFF Research Database (Denmark)

    Menotti, Stefano; Hansen, Hans Nørgaard; Bissacco, Giuliano;

    2014-01-01

    and moulding of smaller and more complex geometries. The last two aspects are very important in micro injection molding. In this paper a new embedded induction heating system is proposed and validated. An experimental investigation was performed based on a test geometry integrating different aspect ratios...... heating system with respect to improvement of replication quality, reduction of injection pressure and injection velocity as well as reduction of cycle time has been verified....

  3. Tracer-Encapsulated Solid Pellet (TESPEL) Injection System for the TJ-II Stellarator

    Energy Technology Data Exchange (ETDEWEB)

    Tamura, N. [National Institute for Fusion Science, Toki, Japan; McCarthy, K. J. [EURATOM-CIEMAT, Madrid, Spain; Hayashi, H. [National Institute for Fusion Science, Toki, Japan; Combs, Stephen Kirk [ORNL; Foust, Charles R [ORNL; Garcia, R. [Laboratory Nacional de Fusion, Madrid, Spain; Panadero, N. [CIEMAT, Laboratory Nacional de Fusion, Spain; Pawelec, E. [Opole University, Poland; Sanchez, J. Hernandez [Laboratory Nacional de Fusion, Madrid, Spain; Navarro, M. [CIEMAT, Laboratory Nacional de Fusion, Spain; Soleto, A. [CIEMAT, Laboratory Nacional de Fusion, Spain

    2016-01-01

    A tracer-encapsulated solid pellet (TESPEL) injection system for the TJ-II stellarator was recently developed. In order to reduce the time and cost for the development, we combined a TESPEL injector provided by National Institute for Fusion Science with an existing TJ-II cryogenic pellet injection system. Consequently, the TESPEL injection into the TJ-II plasma was successfully achieved, which was confirmed by several pellet diagnostics including a normal-incidence spectrometer for monitoring a tracer impurity behavior.

  4. Differential topological characteristics of the DSR on injection space of electrical power system

    Institute of Scientific and Technical Information of China (English)

    余贻鑫; 曾沅; 冯飞

    2002-01-01

    This paper analyzes the differential topological characteristics of the dynamic security region (DSR) on injection space of electrical power system by differential topology theories. It is shown that the boundary of the DSR on injection space has no suspension and is compact, and there are no holes inside the DSR defined based on controlling unstable equilibrium point (UEP) method. The 10-generator, 39-bus New England Test System, is taken as an example to show these characteristics of the DSR on injection space.

  5. Comparison of a needle-free high-pressure injection system with needle-tipped injection of intracavernosal alprostadil for erectile dysfunction.

    Science.gov (United States)

    Harding, L M; Adeniyi, A; Everson, R; Barker, S; Ralph, D J; Baranowski, A P

    2002-12-01

    Patients identified from hospital records as using alprostadil injections for erectile dysfunction were invited to take part in this open crossover study. On alternate weeks eight patients were given intracavernosal needle injections and transdermal needle-free injection of alprostadil in a randomized order. Efficacy of injection and associated pain were assessed and compared for the two methods. Pain produced during injection was significantly greater with the needle-free system than with the needle-tipped injection whilst efficacy was significantly less. Bruising was reported in all except one patient following needle-free injection only. Patient ratings of the needle-free injector were significantly lower than ratings for needle-tipped alprostadil delivery and when asked to express a preference, every patient chose the needle-tipped injection over the needle-free device.

  6. The next generation of injection systems for high-speed diesel engines

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, Ralph Michael; Senghaas, Clemens; Ziegler, Thomas; Willmann, Michael [L' Orange GmbH, Stuttgart (Germany)

    2011-11-15

    With the introduction of Tier 4 engines in the off-highway sector, L'Orange is presenting the next generation of its common rail fuel injection system. The system represents an evolution of the current series and has been improved and enhanced in detail, especially for increased injection pressures and heightened requirements regarding metering accuracy. (orig.)

  7. Dry low NOx combustion system with pre-mixed direct-injection secondary fuel nozzle

    Science.gov (United States)

    Zuo, Baifang; Johnson, Thomas; Ziminsky, Willy; Khan, Abdul

    2013-12-17

    A combustion system includes a first combustion chamber and a second combustion chamber. The second combustion chamber is positioned downstream of the first combustion chamber. The combustion system also includes a pre-mixed, direct-injection secondary fuel nozzle. The pre-mixed, direct-injection secondary fuel nozzle extends through the first combustion chamber into the second combustion chamber.

  8. Improvement of fuel injection system of locomotive diesel engine.

    Science.gov (United States)

    Li, Minghai; Cui, Hongjiang; Wang, Juan; Guan, Ying

    2009-01-01

    The traditional locomotive diesels are usually designed for the performance of rated condition and much fuel will be consumed. A new plunger piston matching parts of fuel injection pump and injector nozzle matching parts were designed. The experimental results of fuel injection pump test and diesel engine show that the fuel consumption rate can be decreased a lot in the most of the working conditions. The forced lubrication is adopted for the new injector nozzle matching parts, which can reduce failure rate and increase service life. The design has been patented by Chinese State Patent Office.

  9. Upgrades to the LHC Injection and Beam Dumping Systems for the HL-LHC Project

    CERN Document Server

    Uythoven, Jan; Goddard, Brennan; Hrivnak, Jan; Lechner, Anton; Maciariello, Fausto; Mereghetti, Alessio; Perillo Marcone, Antonio; Vittal Shetty, N; Shetty, Nikhil Vittal; Steele, Genevieve

    2014-01-01

    The HL-LHC project will push the performance of the LHC injection and beam dumping systems towards new limits. This paper describes the systems affected and presents the new beam parameters for these systems. It also describes the studies to be performed to determine which sub-components of these systems need to be upgraded to fulfil the new HL-LHC requirements. The results from the preliminary upgrade studies for the injection absorbers TDI are presented.

  10. Induction Heating System Applied to Injection Moulding of Micro and Nano Structures

    DEFF Research Database (Denmark)

    Menotti, Stefano

    embedded induction heating system with other heating systems suitable for injection moulding already available on the market. The two selected systems were a variothermal system based on the convective/conductive heating principle and one based on infrared light. During the project simulation software...... and for understanding the influence of the main process parameters on the quality of the parts. The experiments were conducted on a manual injection machine for the first campaign and in a second phase on two different completely automatic injection moulding machines. Metrology was performed to characterize the moulded...

  11. Manufacturing injection-moleded Fresnel lens parquets for point-focus concentrating photovoltaic systems

    Energy Technology Data Exchange (ETDEWEB)

    Peters, E.M.; Masso, J.D. [AOtec, Southbridge, MA (United States)

    1995-10-01

    This project involved the manufacturing of curved-faceted, injection-molded, four-element Fresnel lens parquets for concentrating photovoltaic arrays. Previous efforts showed that high-efficiency (greater than 82%) Fresnel concentrators could be injection molded. This report encompasses the mold design, molding, and physical testing of a four-lens parquet for a solar photovoltaic concentrator system.

  12. Doxycycline Injection

    Science.gov (United States)

    Doxycycline injection is used to treat or prevent bacterial infections, including pneumonia and other respiratory tract infections. ... certain skin, genital, intestine, and urinary system infections. Doxycycline injection may be used to treat or prevent ...

  13. Evaluation of Process Cooling in Subsea Separation, Boosting and Injection Systems (SSBI)

    OpenAIRE

    Gyllenhammar, Svenn Emil

    2012-01-01

    The next generation of subsea process systems will combine the subsea gas compression technology currently under qualification with the previously developed subsea processing technologies, including separation, multiphase pumping and produced water re-injection. These systems will benefit from process cooling. This paper is an evaluation of the use of process cooling in subsea separation, boosting and injection (SSBI) systems including compression. Fouling is the biggest uncertainty, and pote...

  14. An interactive web-based design system for rubber injection mold: Automotive rubber parts

    OpenAIRE

    Chamnarn Thongmark; Jariyaporn Onwong

    2016-01-01

    This research aims at integrating a knowledge-based system and web-based technology to facilitate the rubber and rubber composite injection mold design. The system integrates both of computer-aided design and web-based management by using the application programming interface. The research processes started with gathering data and knowledge concerning on rubber injection mold design and process, with the designed framework of the system included. An example part was demonstrated i...

  15. An interactive web-based design system for rubber injection mold: Automotive rubber parts

    OpenAIRE

    Chamnarn Thongmark; Jariyaporn Onwong

    2016-01-01

    This research aims at integrating a knowledge-based system and web-based technology to facilitate the rubber and rubber composite injection mold design. The system integrates both of computer-aided design and web-based management by using the application programming interface. The research processes started with gathering data and knowledge concerning on rubber injection mold design and process, with the designed framework of the system included. An example part was demonstrated i...

  16. Improved sample injection and illumination for multicapillary systems.

    Science.gov (United States)

    Kahlaoui, Nidhal; Duval, Marie-Alix; Lefebvre, Françoise; Charon, Yves; Siebert, Rainer

    2008-01-01

    Multicapillary electrophoresis continues to see improvements in speed, robustness, and reliability. This paper reports on our work on two components belonging to a multicapillary sequencer developed in our group. Injection of the DNA samples into the capillaries was optimized to make it reproducible and to reduce the amount of sample volume required. An alternative laser illumination of the capillaries was also developed. Light intensity in the capillaries was increased as a result of a step-by-step scanning of the laser and the use of microlenses in front of the capillaries.

  17. A System Call Randomization Based Method for Countering Code-Injection Attacks

    Directory of Open Access Journals (Sweden)

    Zhaohui Liang

    2009-10-01

    Full Text Available Code-injection attacks pose serious threat to today’s Internet. The existing code-injection attack defense methods have some deficiencies on performance overhead and effectiveness. To this end, we propose a method that uses system called randomization to counter code injection attacks based on instruction set randomization idea. System calls must be used when an injected code would perform its actions. By creating randomized system calls of the target process, an attacker who does not know the key to the randomization algorithm will inject code that isn’t randomized like as the target process and is invalid for the corresponding de-randomized module. The injected code would fail to execute without calling system calls correctly. Moreover, with extended complier, our method creates source code randomization during its compiling and implements binary executable files randomization by feature matching. Our experiments on built prototype show that our method can effectively counter variety code injection attacks with low-overhead.

  18. Preliminary investigation of interconnected systems interactions for the safety injection system of Indian Point-3

    Energy Technology Data Exchange (ETDEWEB)

    Alesso, H.P.; Lappa, D.A.; Smith, C.F.; Sacks, I.J.

    1983-03-04

    The rich diversity of ideas and techniques for analyzing interconnected systems interaction has presented the NRC with the problem of identifying methods appropriate for their own review and audit. This report presents the findings of a preliminary study using the Digraph Matrix Analysis method to evaluate interconnected systems interactions for the safety injection system of Indian Point-3. The analysis effort in this study was subjected to NRC constraints regarding the use of Boolean logic, the construction of simplified plant representations or maps, and the development of heuristic measures as specified by the NRC. The map and heuristic measures were found to be an unsuccessful approach. However, from the effort to model and analyze the Indian Point-3 safety injection system, including Boolean logic in the model, singleton and doubleton cut-sets were identified. It is recommended that efforts excluding Boolean logic and utilizing the NRC heuristic measures not be pursed further and that the Digraph Matrix approach (or other comparable risk assessment technique) with Boolean logic included to conduct the audit of the Indian Point-3 systems interaction study.

  19. Detecting Solenoid Valve Deterioration in In-Use Electronic Diesel Fuel Injection Control Systems

    OpenAIRE

    Chyuan-Yow Tseng; Hsun-Heng Tsai

    2010-01-01

    The diesel engine is the main power source for most agricultural vehicles. The control of diesel engine emissions is an important global issue. Fuel injection control systems directly affect fuel efficiency and emissions of diesel engines. Deterioration faults, such as rack deformation, solenoid valve failure, and rack-travel sensor malfunction, are possibly in the fuel injection module of electronic diesel control (EDC) systems. Among these faults, solenoid valve failure is most likely to oc...

  20. THE STUDY OF INTERACTION OF SOLID-LIQUID ADSORPTION SYSTEM BY USING THE FLOW INJECTION-SPECTROPHOTOMETRY SYSTEM

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The flow injection analysis was firstly used for studying a solid-liquid adsorption system,and the dynamics process in the adsorption of dyestuff with regenerable chitin was traced by an online method of flow injection-spectrophotometry. Experimental results indicate that there is a linearization between the tested signals and the height of peaks with reciprocity coefficient 0.9999by using the flow injection-spectrophotometry system to study the dynamics adsorption process in solid-liquid system. The method shows a good stability and reproducibility. It provides a new method for the studies on adsorption dynamics in solid- liquid system.

  1. Designing Fault-Injection Experiments for the Reliability of Embedded Systems

    Science.gov (United States)

    White, Allan L.

    2012-01-01

    This paper considers the long-standing problem of conducting fault-injections experiments to establish the ultra-reliability of embedded systems. There have been extensive efforts in fault injection, and this paper offers a partial summary of the efforts, but these previous efforts have focused on realism and efficiency. Fault injections have been used to examine diagnostics and to test algorithms, but the literature does not contain any framework that says how to conduct fault-injection experiments to establish ultra-reliability. A solution to this problem integrates field-data, arguments-from-design, and fault-injection into a seamless whole. The solution in this paper is to derive a model reduction theorem for a class of semi-Markov models suitable for describing ultra-reliable embedded systems. The derivation shows that a tight upper bound on the probability of system failure can be obtained using only the means of system-recovery times, thus reducing the experimental effort to estimating a reasonable number of easily-observed parameters. The paper includes an example of a system subject to both permanent and transient faults. There is a discussion of integrating fault-injection with field-data and arguments-from-design.

  2. A new shock wave assisted wood preservative injection system

    Science.gov (United States)

    Rao, K. S.; Ravikumar, G.; Lai, Ram; Jagadeesh, G.

    Preservative treatment of many tropical hard woods and bamboo pose severe problem. A number of wood preservatives (chemical formulations toxic to wood decay/ destroying organisms like fungi, wood destroying termites, marine borers etc.) and wood impregnating techniques are currently in use for improving bio resistance of timber and bamboo and thereby enhancing service life for different end uses. How ever, some species of tropical hardwoods and many species of bamboo are difficult to treat, posing technical problems. In this paper we report preliminary results of treatment of bamboo with a novel Shockwave assisted injection treatment. Samples (30×2.5×1.00 cm) of an Indian species of bamboo Dendrocalamus strictus prepared from defect free culms of dry bamboo are placed in the driven section of a vertical shock tube filled with the 4Coppepr-Chrome-Arsenic(CCA) preservative solution.The bamboo samples are subjected to repeated shock wave loading (3 shots) with typical over pressures of 30 bar. The results from the study indicate excellent penetration and retention of CCA preservative in bamboo samples. The method itself is much faster compared to the conventional methods like pressure treatment or hot and cold process.

  3. Multipoint Grout Injection System. Innovative Technology Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    None

    2001-09-01

    At the Oak Ridge Reservation (ORR), radioactive waste contained in the 16 cylindrical Gunite and Associated Tanks (GAATs) must retrieved so the tanks can be closed. In many cases, removing the small amounts of sludge that remain in the tank after the bulk of the waste is retrieved is extremely costly and provides little benefit from site health and environmental standpoints. The Tanks Focus Area is working with ORR's M and I contractor (Bechtel-Jacobs), Oak Ridge National Laboratory, and Ground Environmental Services to demonstrate the application of multi-point-injection (MPI) grout emplacement technology for horizontal cylindrical tanks during a cold demonstration in FY99. GAAT TH-4 has been identified as the tank to be used for the hot demonstration in FY00. Evaluation efforts continue on the effect of slag on strength performance of the grout to be used in TH-4 tank closure. The site must find out what level of slag can be accommodated in the grout while maintaining strength performance requirements. Other efforts in support of the utilization of MPI TM technology in large-scale waste tanks will continue. Also, ORR is collaborating with SRS to evaluate the use this technology to support grouting of the Old Burial Ground tanks at SRS.

  4. An Innovative Injection and Mixing System for Diesel Fuel Reforming

    Energy Technology Data Exchange (ETDEWEB)

    Spencer Pack

    2007-12-31

    This project focused on fuel stream preparation improvements prior to injection into a solid oxide fuel cell reformer. Each milestone and the results from each milestone are discussed in detail in this report. The first two milestones were the creation of a coking formation test rig and various testing performed on this rig. Initial tests indicated that three anti-carbon coatings showed improvement over an uncoated (bare metal) baseline. However, in follow-up 70 hour tests of the down selected coatings, Scanning Electron Microscope (SEM) analysis revealed that no carbon was generated on the test specimens. These follow-up tests were intended to enable a down selection to a single best anti-carbon coating. Without the formation of carbon it was impossible to draw conclusions as to which anti-carbon coating showed the best performance. The final 70 hour tests did show that AMCX AMC26 demonstrated the lowest discoloration of the metal out of the three down selected anti-carbon coatings. This discoloration did not relate to carbon but could be a useful result when carbon growth rate is not the only concern. Unplanned variations in the series of tests must be considered and may have altered the results. Reliable conclusions could only be drawn from consistent, repeatable testing beyond the allotted time and funding for this project. Milestones 3 and 4 focused on the creation of a preheating pressure atomizer and mixing chamber. A design of experiment test helped identify a configuration of the preheating injector, Build 1, which showed a very uniform fuel spray flow field. This injector was improved upon by the creation of a Build 2 injector. Build 2 of the preheating injector demonstrated promising SMD results with only 22psi fuel pressure and 0.7 in H2O of Air. It was apparent from testing and CFD that this Build 2 has flow field recirculation zones. These recirculation zones may suggest that this Build 2 atomizer and mixer would require steam injection to reduce the

  5. Fuel injection and mixing systems having piezoelectric elements and methods of using the same

    Science.gov (United States)

    Mao, Chien-Pei [Clive, IA; Short, John [Norwalk, IA; Klemm, Jim [Des Moines, IA; Abbott, Royce [Des Moines, IA; Overman, Nick [West Des Moines, IA; Pack, Spencer [Urbandale, IA; Winebrenner, Audra [Des Moines, IA

    2011-12-13

    A fuel injection and mixing system is provided that is suitable for use with various types of fuel reformers. Preferably, the system includes a piezoelectric injector for delivering atomized fuel, a gas swirler, such as a steam swirler and/or an air swirler, a mixing chamber and a flow mixing device. The system utilizes ultrasonic vibrations to achieve fuel atomization. The fuel injection and mixing system can be used with a variety of fuel reformers and fuel cells, such as SOFC fuel cells.

  6. Development of a plastic injection molding training system using Petri nets and virtual reality

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    In this study, Virtual Reality (VR)-based plastic injection molding training system (VPIMTS), which can be modeled as an integrated system with a task planning module, an intelligent instruction module, a simulation module, and virtual environment (VE) module, was developed. Presented in this paper are an architecture of VPIMTS, a practical knowledge modelling approach for modelling the training scenarios of the system by using Petri nets formalism and key techniques (FEM, injection molding procedure modelling) which have been developed independently. The utilization of the Petri net model realized the environment where the trainee can behave freely, and also made it possible to equip the system with the function of showing the next action of the trainee whenever he wants. The overall system is a powerful approach for highly improving the trainee's comprehension and injection molding study-efficiency by building digital, intelligent, knowledgeable, and visual aids.

  7. Development of the computer-aided process planning (CAPP) system for polymer injection molds manufacturing

    OpenAIRE

    J. Tepić; V. Todić; Lukić, D.; Milošević, M.; Borojević, S.

    2011-01-01

    Beginning of production and selling of polymer products largely depends on mold manufacturing. The costs of mold manufacturing have significant share in the final price of a product. The best way to improve and rationalize polymer injection molds production process is by doing mold design automation and manufacturing process planning automation. This paper reviews development of a dedicated process planning system for manufacturing of the mold for injection molding, which integrates computer-...

  8. Materials for High-Pressure Fuel Injection Systems

    Energy Technology Data Exchange (ETDEWEB)

    Blau, P.; Shyam, A.; Hubbard, C.; Howe, J.; Trejo, R.; Yang, N. (Caterpillar, Inc. Technical Center); Pollard, M. (Caterpillar, Inc. Technical Center)

    2011-09-30

    . Compared to the smooth specimens, EDM notching led to a severe reduction in total fatigue life. A reduction in fatigue life of nearly four orders of magnitude can occur at an EDM notch the approximate size of fuel injector spray holes. Consequently, the initiation and propagation behavior of cracks from small spray holes is relevant for generation of design quality data for the next generation diesel fuel injection devices. This is especially true since the current design methodologies usually rely on the less conservative smooth specimen fatigue testing results, and since different materials can have varying levels of notch fatigue resistance.

  9. Nitrous Oxide Liquid Injection Thrust Vector Control System Testing Project

    Data.gov (United States)

    National Aeronautics and Space Administration — A Nitrous Oxide-fed Liquid Thrust Vector Control system is proposed as an efficient method for vehicle attitude control during powered flight. Pulled from a N2O main...

  10. Development of injection gas heating system for introducing large droplets to inductively coupled plasma.

    Science.gov (United States)

    Kaburaki, Yuki; Nomura, Akito; Ishihara, Yukiko; Iwai, Takahiro; Miyahara, Hidekazu; Okino, Akitoshi

    2013-01-01

    We developed an injection gas heating system for introducing large droplets, because we want to effectively to measure elements in a single cell. This system was applied to ICP-atomic emission spectrometry (ICP-AES), to evaluate it performance. To evaluate the effect of the emission intensity, the emission intensity of Ca(II) increased to a maximum of tenfold at 147°C and the peak was shifted upstream of the plasma. To investigate in detail the effect of an injection gas heating system, we studied different conditions of the injection gas temperature and droplet volume. When the injection gas temperature was 89°C, smaller droplets were easily ionized. At 147°C, the emission intensity ratio and the absolute amount of the sample including the droplet exhibited close agreement. These results show the advantages of the injection gas heating system for large droplet introduction, and the sufficient reduction in the solvent load. The solvent load could be reduced by heating to 147°C using the system.

  11. Design and development of the helicity injection system in Versatile Experiment Spherical Torus

    Energy Technology Data Exchange (ETDEWEB)

    Park, JongYoon; An, Younghwa; Jung, Bongki; Lee, Jeongwon; Lee, HyunYoung; Chung, Kyoung-Jae; Na, Yong-Su; Hwang, Y.S., E-mail: yhwang@snu.ac.kr

    2015-10-15

    Graphical abstract: - Highlights: • A high current electron gun with single pulse power for both arc and extraction is developed. • The optimal gun operation is confirmed by impedance matching between the PFN and plasma. • The gun injected currents of 0.95 kA with the voltage of ∼410 V for 5 ms with a 1.2 kV PFN. • The helicity injection system using the gun has been developed and tested successfully in VEST. • Toroidal currents of up to 3.8 kA confirm possible relaxation into tokamak-like plasma. - Abstract: A helicity injection system for the Versatile Experiment Spherical Torus (VEST) has been successfully developed and commissioned. A high current electron gun utilizing hollow cathode and washer stacks has been designed and constructed with a single pulse power system that can provide voltages for both arc discharge and extraction sequentially. Tests for electron gun operation with the single pulse power system have been conducted under various toroidal and poloidal field strengths. The estimated plasma impedance, depending on the injection magnetic field structure, can be utilized for the optimal gun operation by impedance matching between the pulse power system and plasma. With the charging voltage of 1.2 kV, injection current of 0.95 kA has been obtained with the injection voltage of 410 V for about 5 ms. Initial helicity injection experiments have been conducted under various toroidal and poloidal field strengths and a toroidal plasma current of up to 3.8 kA is observed with the current multiplication larger than the geometric stacking ratio, confirming the possibility of relaxation into tokamak-like plasma with closed flux formation.

  12. Low emittance pre-injection system for Iranian Light Source Facility

    Energy Technology Data Exchange (ETDEWEB)

    Sadeghipanah, A., E-mail: a.sadeghipanah@ipm.ir [Radiation Applications Department, Shahid Beheshti University, G. C., Tehran (Iran, Islamic Republic of); Feghhi, A.H. [Radiation Applications Department, Shahid Beheshti University, G. C., Tehran (Iran, Islamic Republic of); Rahighi, J. [Iranian Light Source Facility (ILSF), Institute for Research in Fundamental Sciences (IPM), Tehran (Iran, Islamic Republic of); Ghasem, H. [Iranian Light Source Facility (ILSF), Institute for Research in Fundamental Sciences (IPM), Tehran (Iran, Islamic Republic of); School of Particles and Accelerators, Institute for Research in Fundamental Sciences (IPM), Tehran (Iran, Islamic Republic of)

    2016-01-11

    In this paper, we introduce the Iranian Light Source Facility (ILSF) pre-injection system. The optimized parameters of its components, the related beam dynamics issues and the expected performance of the designed system have been described with detail. This paper explains fabrication procedures of some main components and gives the low power microwave measurement results of the constructed RF electron gun. The outcome bunches at the end of the ILSF pre-injection system will have the normalized emittance of 6 mm mrad, length of 1.55 ps and energy spread of 0.06%.

  13. Parallel Damping Injection for the Quarter Car Suspension System.

    NARCIS (Netherlands)

    Scherpen, Jacquelien M.A.; Jeltsema, Dimitri; Maulny, François

    2006-01-01

    In this paper we study an application of Passivity-Based Control (PBC) to a quarter car suspension system. We use Passivity-Based Control in the Brayton-Moser framework (BM-PBC) that has recently been developed for control of switching and non-switching electrical circuits. Via the usual mass-induct

  14. Fertigation - Injecting soluble fertilizers into the irrigation system

    Science.gov (United States)

    Thomas D. Landis; Jeremy R. Pinto; Anthony S. Davis

    2009-01-01

    Fertigation (fertilization + irrigation) is the newest way for nursery managers to apply fertilizer, and has become a standard practice in container nurseries. Because of the inherent inefficient water distribution patterns in field irrigation systems, fertigation has not been widely used in bareroot nurseries. However, a bareroot nursery with a center-pivot irrigation...

  15. Semicircular lipoatrophy in a child with systemic lupus erythematosus after subcutaneous injections with methotrexate.

    Science.gov (United States)

    Haas, Norbert; Henz, Beate M; Bunikowski, Rita; Keitzer, Rolf

    2002-01-01

    Lipoatrophia semicircularis, a rare entity which presents as atrophic cutaneous indentations exclusively on the anterior thighs of women, is thought to result from physical trauma. Localized lipoatrophies are common following injection with drugs and occur in patients with collagen disease. We report a 10-year-old girl who developed semicircular lipoatrophy on the anterior thighs after treatment of systemic lupus erythematosus (SLE) with subcutaneous injections of methotrexate. Until now, subcutaneously administered methotrexate has not been reported to cause lipoatrophy. Other possible causes include underlying autoimmune disease, the predisposition for females to be affected, and local trauma, also from the injections, at the specific body site. We suggest that subcutaneous injections with methotrexate on the anterior thighs should be avoided or monitored closely in female patients with SLE.

  16. Determining the optimal amount of gas that is injected for the Gaslift system work

    Directory of Open Access Journals (Sweden)

    Danilović Dušan Š.

    2014-01-01

    Full Text Available The problem that arises in the work of wells in the oil field Gaslift Amal to individual wells do not always have the necessary amount of gas for injection. Therefore, in a borehole at a depth of injection, the operating valve, there is not enough dynamic pressure for the removal of oil on the surface. This is particularly evident in wells with increased production of formation water. For this reason, the paper presents the methodology and drafted model for optimal allocation of the amount of gas injected into each well in the work gaslift of the system. The methodology for the allocation of quantities of gas injection through the so-called cumulative curves based on the dynamic characteristics of each well.

  17. System for injecting fuel in a gas turbine combustor

    Science.gov (United States)

    Berry, Jonathan Dwight

    2016-10-25

    A combustion system uses a fuel nozzle with an inner wall having a fuel inlet in fluid communication with a fuel outlet in a fuel cartridge. The inner wall defines a mounting location for inserting the fuel cartridge. A pair of annular lip seals around the cartridge outer wall on both sides of the fuel outlet seals the fuel passage between the fuel inlet and the fuel outlet.

  18. Learning Runtime Parameters in Computer Systems with Delayed Experience Injection

    OpenAIRE

    Schaarschmidt, Michael; Gessert, Felix; Dalibard, Valentin; Yoneki, Eiko

    2016-01-01

    Learning effective configurations in computer systems without hand-crafting models for every parameter is a long-standing problem. This paper investigates the use of deep reinforcement learning for runtime parameters of cloud databases under latency constraints. Cloud services serve up to thousands of concurrent requests per second and can adjust critical parameters by leveraging performance metrics. In this work, we use continuous deep reinforcement learning to learn optimal cache expiration...

  19. Performance Evaluation of a Software Engineering Tool for Automated Design of Cooling Systems in Injection Moulding

    DEFF Research Database (Denmark)

    Jauregui-Becker, Juan M.; Tosello, Guido; van Houten, Fred J.A.M.

    2013-01-01

    This paper presents a software tool for automating the design of cooling systems for injection moulding and a validation of its performance. Cooling system designs were automatically generated by the proposed software tool and by applying a best practice tool engineering design approach. The two...

  20. A micro spot injection system for studing the effects of carbonation on fumigant dispersion in soil

    Science.gov (United States)

    Fumigant transport to deep soils is needed to control plant parasitic nematodes and soil borne pathogens for perennial crops. Using carbonated fumigants and carbon dioxide (CO2)-pressurized fumigant injection systems may achieve this target when compared to conventional fumigation systems pressurize...

  1. Injectable nanoparticle-loaded hydrogen system for local delivery of sodium alendronate

    NARCIS (Netherlands)

    Posadowska, U.; Parizek, M.; Filova, E.; Wlodarczyk-Biegun, M.K.; Kamperman, M.M.G.; Bacakova, L.; Pamula, E.

    2015-01-01

    Systemic administration of bisphosphonates, e.g. sodium alendronate (Aln) is characterized by extremely low bioavailability and high toxicity. To omit aforementioned drawbacks an injectable system for the intra-bone delivery of Aln based on Aln-loaded nanoparticles (NPs-Aln) suspended in a hydrogel

  2. Research on the technology of detecting the SQL injection attack and non-intrusive prevention in WEB system

    Science.gov (United States)

    Hu, Haibin

    2017-05-01

    Among numerous WEB security issues, SQL injection is the most notable and dangerous. In this study, characteristics and procedures of SQL injection are analyzed, and the method for detecting the SQL injection attack is illustrated. The defense resistance and remedy model of SQL injection attack is established from the perspective of non-intrusive SQL injection attack and defense. Moreover, the ability of resisting the SQL injection attack of the server has been comprehensively improved through the security strategies on operation system, IIS and database, etc.. Corresponding codes are realized. The method is well applied in the actual projects.

  3. Systemic effects of epidural methylprednisolone injection on glucose tolerance in diabetic patients

    Directory of Open Access Journals (Sweden)

    Zufferey Pascal

    2011-12-01

    Full Text Available Abstract Background Several studies have shown that in diabetic patients, the glycemic profile was disturbed after intra-articular injection of corticosteroids. Little is known about the impact of epidural injection in such patients. The goal of this study was double, at first comparing the glycaemic profile in diabetic patients after a unique injection of 80 mg of acetate methylprednisolone either intra-articular or epidural and secondly to compare the amount of systemic diffusion of the drug after both procedures. Methods Seventeen patients were included. Glycemic changes were compared in 9 diabetic patients following intra-articular (4 patients and epidural injections (5 patients. Epidural injections were performed using the sacral route under fluoroscopic control in patients with lumbar spinal stenosis. Diabetes control had to stable for more than 10 days and the renal function to be preserved. Blood glucose was monitored using a validated continuous measuring device (GMS, Medtronic the day before and for two days following the injection. Results were expressed in the form of daily glycemic profiles and as by mean, peak and minimal values +/- SD. The urinary excretion of methylprednisolone after the 2 routes of injection was analyzed in 8 patients (4 in each group. Urine samples were cropped one hour before the injections, then 4 times during the first day and 3 times a week for 2 weeks. The measurements included the free and conjugated fraction Results The glycaemic profile remains unchanged with no significant changes in the group of the 5 diabetic patients receiving epidural injections. On the other end, the average peak and and mean values were enhanced up to 3 mmol/l above baseline two days after the infiltration in the groups of the 4 diabetic patients infiltrated intra-articular. The mean urinary excretion of the steroid was about ten times higher in the intra-articular versus epidural group: 7000 ng/ml versus 700 ng/ml. Looking at

  4. Droplet-based microfluidic flow injection system with large-scale concentration gradient by a single nanoliter-scale injection for enzyme inhibition assay.

    Science.gov (United States)

    Cai, Long-Fei; Zhu, Ying; Du, Guan-Sheng; Fang, Qun

    2012-01-03

    We described a microfluidic chip-based system capable of generating droplet array with a large scale concentration gradient by coupling flow injection gradient technique with droplet-based microfluidics. Multiple modules including sample injection, sample dispersion, gradient generation, droplet formation, mixing of sample and reagents, and online reaction within the droplets were integrated into the microchip. In the system, nanoliter-scale sample solution was automatically injected into the chip under valveless flow injection analysis mode. The sample zone was first dispersed in the microchannel to form a concentration gradient along the axial direction of the microchannel and then segmented into a linear array of droplets by immiscible oil phase. With the segmentation and protection of the oil phase, the concentration gradient profile of the sample was preserved in the droplet array with high fidelity. With a single injection of 16 nL of sample solution, an array of droplets with concentration gradient spanning 3-4 orders of magnitude could be generated. The present system was applied in the enzyme inhibition assay of β-galactosidase to preliminarily demonstrate its potential in high throughput drug screening. With a single injection of 16 nL of inhibitor solution, more than 240 in-droplet enzyme inhibition reactions with different inhibitor concentrations could be performed with an analysis time of 2.5 min. Compared with multiwell plate-based screening systems, the inhibitor consumption was reduced 1000-fold.

  5. Computer Aided Design of The Cooling System for Plastic Injection Molds

    Directory of Open Access Journals (Sweden)

    Hakan GÜRÜN

    2009-02-01

    Full Text Available The design of plastic injection molds and their cooling systems affect both the dimension, the shape, the quality of a plastic part and the cycle time of process and the cost of mold. In this study, the solid model design of a plastic injection mold and the design of cooling sysytem were possibly carried out without the designer interaction. Developed program permited the use of three types of the cooling system and the different cavity orientations and the multible plastic part placement into the mold cores. The program which was developed by using Visual LISP language and the VBA (Visual BASIC for Application modules, was applicated in the AutoCAD software domain. Trial studies were presented that the solid model design of plastic injection molds and the cooling systems increased the reliability, the flexibility and the speed of the design.

  6. Design of the Injection and extraction system and related machine protection for the Clic Damping Rings

    CERN Document Server

    Apsimon, Robert; Barnes, Mike; Borburgh, Jan; Goddard, Brennan; Papaphilippou, Yannis; Uythoven, Jan

    2014-01-01

    Linear machines such as CLIC have relatively low rates of collision between bunches compared to their circular counterparts. In order to achieve the required luminosity, a very small spot size is envisaged at the interaction point, thus a low emittance beam is needed. Damping rings are essential for producing the low emittances needed for the CLIC main beam. It is crucial that the beams are injected and extracted from the damping rings in a stable and repeatable fashion to minimise emittance blow-up and beam jitter at the interaction point; both of these effects will deteriorate the luminosity at the interaction point. In this paper, the parameters and constraints of the injection and extraction systems are considered and the design of these systems is optimised within this parameter space. Related machine protection is considered in order to prevent damage from potential failure modes of the injection and extraction systems.

  7. Study on the magnetic measurement results of the injection system for CSNS/RCS

    CERN Document Server

    Huang, Ming-Yang; Huang, Nan; Huo, Li-Hua; Ji, Hong-Fei; Kang, Wen; Liu, Yi-Qin; Peng, Jun; Qiu, Jing; Shen, Li; Wang, Sheng; Wu, Xi; Xu, Shou-Yan; Zhang, Jing; Zhou, Guo-Zhong

    2016-01-01

    A combination of the H- stripping and phase space painting method is used to accumulate a high intensity beam in the Rapid Cycling Synchrotron (RCS) of the China Spallation Neutron Source (CSNS). The injection system for CSNS/RCS consists of three kinds of magnets: four direct current magnets (BC1-BC4), eight alternating current magnets (BH1-BH4 and BV1-BV4), two septum magnets (ISEP1 and ISEP2). In this paper, the magnetic measurements of the injection system were introduced and the data analysis was processed. The field uniformity and magnetizing curves of these magnets were given, and then the magnetizing fitting equations were obtained.

  8. Design of the beam transport line and injection system of the compact storage ring for TTX

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    In this article, we present the design of the beam transport line and injection system of the compact storage ring for the Tsinghua Thomson scattering X-ray (TTX) source. The layout of the beam transport line fits in with the limited available space. The injection system is simplified, consisting of only one single kicker; the stray field on the reference orbit is also reduced without the septum magnet. We choose a travelling wave kicker and present both 2D and 3D simulations for the structure design.

  9. Recovery of injected freshwater from a brackish aquifer with a multiwell system.

    Science.gov (United States)

    Miotliński, Konrad; Dillon, Peter J; Pavelic, Paul; Barry, Karen; Kremer, Sarah

    2014-01-01

    Herein we propose a multiple injection and recovery well system strategically operated for freshwater storage in a brackish aquifer. With the system we call aquifer storage transfer and recovery (ASTR) by using four injection and two production wells, we are capable of achieving both high recovery efficiency of injected freshwater and attenuation of contaminants through adequately long residence times and travel distances within the aquifer. The usual aquifer storage and recovery (ASR) scheme, in which a single well is used for injection and recovery, does not warrant consistent treatment of injected water due to the shorter minimum residence times and travel distances. We tested the design and operation of the system over 3 years in a layered heterogeneous limestone aquifer in Salisbury, South Australia. We demonstrate how a combination of detailed aquifer characterization and solute transport modeling can be used to maintain acceptable salinity of recovered water for its intended use along with natural treatment of recharge water. ASTR can be used to reduce treatment costs and take advantage of aquifers with impaired water quality that might locally not be otherwise beneficially used.

  10. Attack methodology Analysis: SQL Injection Attacks and Their Applicability to Control Systems

    Energy Technology Data Exchange (ETDEWEB)

    Bri Rolston

    2005-09-01

    Database applications have become a core component in control systems and their associated record keeping utilities. Traditional security models attempt to secure systems by isolating core software components and concentrating security efforts against threats specific to those computers or software components. Database security within control systems follows these models by using generally independent systems that rely on one another for proper functionality. The high level of reliance between the two systems creates an expanded threat surface. To understand the scope of a threat surface, all segments of the control system, with an emphasis on entry points, must be examined. The communication link between data and decision layers is the primary attack surface for SQL injection. This paper facilitates understanding what SQL injection is and why it is a significant threat to control system environments.

  11. A harmonic injection SPWM method for the high-responsive PMSM control system

    Science.gov (United States)

    Lei, Wang; Shuanghui, Hao; Minghui, Hao; Baoyu, Song

    2016-01-01

    In a permanent magnet synchronous motor (PMSM) control system, usually, the phase voltage instruction is limited independently to prevent a three-phase pulse width modulation (PWM) wave from overflowing. This method decreases the efficiency of the bus voltage and causes voltage vector direction errors. To solve these problems, we propose a harmonic injection sinusoidal pulse-width modulation (SPWM). This method uses harmonic injected sinusoidal PWM to improve the utilisation ratio of the bus voltage, and consequently improve system performance. In this paper, we analyse the problem in terms of potential difference. The simulation results show that the proposed method can increase the utilisation ratio of the bus voltage up to 15.4%, and the voltage vector mode obtained with the proposed algorithm is larger than that obtained with the conventional one. The method with harmonic injection consequently improves current response, without affecting voltage vector accuracy. The experiment results validate the proposed method.

  12. An interactive web-based design system for rubber injection mold: Automotive rubber parts

    Directory of Open Access Journals (Sweden)

    Chamnarn Thongmark

    2016-10-01

    Full Text Available This research aims at integrating a knowledge-based system and web-based technology to facilitate the rubber and rubber composite injection mold design. The system integrates both of computer-aided design and web-based management by using the application programming interface. The research processes started with gathering data and knowledge concerning on rubber injection mold design and process, with the designed framework of the system included. An example part was demonstrated in order to validate the developed system. Based on standardized procedures, the system provides counseling that is able to resolve relevant issues at the early stage of the mold design. The system can be used for both designing and training in rubber mold fabrication.

  13. Systemic and local injections of lupeol inhibit tumor growth in a melanoma-bearing mouse model.

    Science.gov (United States)

    Nitta, Makiko; Azuma, Kazuo; Hata, Keishi; Takahashi, Saori; Ogiwara, Kikumi; Tsuka, Takeshi; Imagawa, Tomohiro; Yokoe, Inoru; Osaki, Tomohiro; Minami, Saburo; Okamoto, Yoshiharu

    2013-07-01

    Melanoma is the most aggressive type of skin cancer and it is procured from activated or genetically altered epidermal melanocytes. In the present study, the tumor-suppressive effects of systemic and local injections of lupeol, a triterpene extracted from Indian lettuce (Lactuca indica), in a melanoma-bearing mouse model were evaluated. Mice were injected once with lupeol or olive oil (solvent control) subcutaneously into the skin of the back or into the tumor tissue. Seven days after the injection, the tumor growth rates were calculated and the tumor tissues were collected. Immunohistochemical staining for Ki-67 and proliferating cell nuclear antigen (PCNA) were performed. The tumor growth rates in the lupeol-injected group were significantly decreased compared to those observed in the non-treated (NT) and solvent control groups. Lupeol also significantly decreased the areas positively stained for Ki-67 and PCNA in the tumor tissues compared to those in the NT and solvent control groups. The results of the present study demonstrated that systemic and local injections of lupeol suppress tumor growth and induce cell cycle arrest in a melanoma-bearing mouse model. These data suggest that lupeol may be effective as a novel therapeutic option for melanoma patients.

  14. Development of Haptic Needle for VR Based Injection Training System Using Simulated Patient.

    Science.gov (United States)

    Nishio, Kohei; Nakaguchi, Toshiyia

    2016-01-01

    VR based injection training system using standardized patient was proposed. This system uses haptic needle (HNSP) which can represent haptic force. Since the previously proposed system had a few problems with haptic reproduction, biological reproducibility needed to be improved. In order to solve these problems, we developed a new HNSP to replace the haptic needle. In addition, we conducted two validation studies for the HNSP.

  15. Preliminary Failure Modes and Effects Analysis of the US Massive Gas Injection Disruption Mitigation System Design

    Energy Technology Data Exchange (ETDEWEB)

    Lee C. Cadwallader

    2013-10-01

    This report presents the results of a preliminary failure modes and effects analysis (FMEA) of a candidate design for the ITER Disruption Mitigation System. This candidate is the Massive Gas Injection System that provides machine protection in a plasma disruption event. The FMEA was quantified with “generic” component failure rate data as well as some data calculated from operating facilities, and the failure events were ranked for their criticality to system operation.

  16. Elimination of Fuel Pressure Fluctuation and Multi-injection Fuel Mass Deviation of High Pressure Common-rail Fuel Injection System

    Institute of Scientific and Technical Information of China (English)

    LI Pimao; ZHANG Youtong; LI Tieshuan; XIE Lizhe

    2015-01-01

    The influence of fuel pressure fluctuation on multi-injection fuel mass deviation has been studied a lot, but the fuel pressure fluctuation at injector inlet is still not eliminated efficiently. In this paper, a new type of hydraulic filter consisting of a damping hole and a chamber is developed for elimination of fuel pressure fluctuation and multi-injection fuel mass deviation. Linear model of the improved high pressure common-rail system(HPCRS) including injector, the pipe connecting common-rail with injector and the hydraulic filter is built. Fuel pressure fluctuation at injector inlet, on which frequency domain analysis is conducted through fast Fourier transformation, is acquired at different target pressure and different damping hole diameter experimentally. The linear model is validated and can predict the natural frequencies of the system. Influence of damping hole diameter on fuel pressure fluctuation is analyzed qualitatively based on the linear model, and it can be inferred that an optimal diameter of the damping hole for elimination of fuel pressure fluctuation exists. Fuel pressure fluctuation and fuel mass deviation under different damping hole diameters are measured experimentally, and it is testified that the amplitude of both fuel pressure fluctuation and fuel mass deviation decreases first and then increases with the increasing of damping hole diameter. The amplitude of main injection fuel mass deviation can be reduced by 73%at most under pilot-main injection mode, and the amplitude of post injection fuel mass deviation can be reduced by 92%at most under main-post injection mode. Fuel mass of a single injection increases with the increasing of the damping hole diameter. The hydraulic filter proposed by this research can be potentially used to eliminate fuel pressure fluctuation at injector inlet and improve the stability of HPCRS fuel injection.

  17. Efficacy of INOVOJECT egg injection system for delivering Marek's disease vaccine under hatchery conditions.

    Science.gov (United States)

    Marsh, T E; Fluke, D K; Villegas, P

    1997-01-01

    The ability of the INOVOJECT egg injection system to effectively deliver the appropriate titer of herpesvirus of turkeys (HVT) vaccine during normal hatchery operation was evaluated. The INOVOJECT machines configured for the Jamesway and Chickmaster commercial hatchers both maintained the integrity of the HVT vaccine without an appreciable loss in titer from the diluted vaccine to the egg.

  18. Diesel Engine with Different Kind of Injection Systems Exhaust Gas Analysis

    Directory of Open Access Journals (Sweden)

    Mantas Smolnikovas

    2016-02-01

    Full Text Available The article presents an overview of structural evolution of diesel engines’ injection systems, air pollution caused by diesel engines and permissible emission rates. An analytical research on air pollution was also performed. Experimental studies evaluated air pollution during the emission of particulate matter according to diesel engine exploitation time and different constructions emissions.

  19. Flow injection chemiluminescence determination of loxoprofen and naproxen with the acidic permanganate-sulfite system

    Institute of Scientific and Technical Information of China (English)

    Li-Juan Wang; Yu-Hai Tang; Yang-Hao Liu

    2011-01-01

    A novel flow injection chemiluminescence(CL)method for the determination of loxoprofen and naproxen was proposed based on the CL system of KMnO4 and Na2SO3 in acid media.The CL intensity of KMnO4-Na2SO3 was greatly enhanced in the presence of loxoprofen a

  20. B and Li isotopes as intrinsic tracers for injection tests in aquifer storage and recovery systems

    Energy Technology Data Exchange (ETDEWEB)

    Kloppmann, Wolfram, E-mail: w.kloppmann@brgm.fr [BRGM, French Geological Survey, 3 Av. Claude Guillemin B.P. 6009, F-45000 Orleans (France); Chikurel, Haim [Mekorot National Water Company, Tel Aviv (Israel); Picot, Geraldine [BRGM, French Geological Survey, 3 Av. Claude Guillemin B.P. 6009, F-45000 Orleans (France); Guttman, Joseph [Mekorot National Water Company, Tel Aviv (Israel); Pettenati, Marie [BRGM, French Geological Survey, 3 Av. Claude Guillemin B.P. 6009, F-45000 Orleans (France); Aharoni, Avi [Mekorot National Water Company, Tel Aviv (Israel); Guerrot, Catherine; Millot, Romain; Gaus, Irina [BRGM, French Geological Survey, 3 Av. Claude Guillemin B.P. 6009, F-45000 Orleans (France); Wintgens, Thomas [Rheinisch Westfaelische Technische Hochschule, RWTH, Aachen (Germany)

    2009-07-15

    Boron and Li isotopes have been tested as environmental tracers of treated sewage injected into a sandy aquifer (Shafdan reclamation project, Israel). During a 38 days injection test in a newly dug injection well, a conservative artificial tracer (Br{sup -}) was monitored together with {delta}{sup 11}B and {delta}{sup 7}Li in the injectate, in the unsaturated soil zone (porous cup) and an observation well in the aquifer. In spite of B and Li concentrations in the injectate close to background values, significant shifts of the isotope signatures could be observed over the duration of the injection test. Boron isotope ratios show a breakthrough curve delayed with respect to Br{sup -} breakthrough due to some reversible sorption on the aquifer material. No isotope fractionation was observed in the unsaturated or the saturated zone so that B isotopes can be considered as conservative in the investigated part of the aquifer system. Lithium isotopes are strongly fractionated, probably due to sorption processes. Lithium concentrations point to a Li sink in the system, {delta}{sup 7}Li values vary strongly with a tendency of {sup 7}Li depletion in the liquid phase over the duration of the experiment. This is opposite to the expected preferential sorption of {sup 6}Li onto clay minerals. Boron isotopes reveals a valuable tracer of artificial recharge of freshwaters derived from treated sewage, both for short term tracer tests and for long-term monitoring of artificial recharge, even if in aquifers with higher clay contents, sorption-linked isotope fractionation cannot be excluded. More data are needed on Li isotope fractionation in natural groundwater systems to assess the potential of this tracer as monitoring tool.

  1. Development of the computer-aided process planning (CAPP system for polymer injection molds manufacturing

    Directory of Open Access Journals (Sweden)

    J. Tepić

    2011-10-01

    Full Text Available Beginning of production and selling of polymer products largely depends on mold manufacturing. The costs of mold manufacturing have significant share in the final price of a product. The best way to improve and rationalize polymer injection molds production process is by doing mold design automation and manufacturing process planning automation. This paper reviews development of a dedicated process planning system for manufacturing of the mold for injection molding, which integrates computer-aided design (CAD, computer-aided process planning (CAPP and computer-aided manufacturing (CAM technologies.

  2. Electrical spin injection and detection in high mobility 2DEG systems

    Science.gov (United States)

    Ciorga, M.

    2016-11-01

    In this review paper we present the current status of research related to the topic of electrical spin injection and detection in two-dimensional electron gas (2DEG) systems, formed typically at the interface between two III-V semiconductor compounds. We discuss both theoretical aspects of spin injection in case of ballistic transport as well as give an overview of available reports on spin injection experiments performed on 2DEG structures. In the experimental part we focus particularly on our recent work on all-semiconductor structures with a 2DEG confined at an inverted GaAs/(Al,Ga)As interface and with a ferromagnetic semiconductor (Ga,Mn)As employed as a source of spin-polarized electrons.

  3. Investigation of Amourphous Deposits and Potential Corrosion Mechanisms in Offshore Water Injection Systems

    DEFF Research Database (Denmark)

    Eroini, Violette; Oehler, Mike Christian; Graver, Britt Kathrine

    2017-01-01

    , composed of both organic and inorganic compounds, has caused concerns within operating assets due to the detrimental effect on production and injection, in addition to challenges with intervention and integrity. The variety of deposits and poor understanding of their nature has led to confusion......Increasing incidence of amorphous deposits in both production and water injection systems has caused considerable problems for offshore oil fields. Amorphous deposits, which are a widely recognized, but often poorly explained phenomenon, are typically comprised of both organic (biological...... or hydrocarbons) and inorganic material, but with compositions that vary considerably. One recurrent form of deposits, found in offshore water injection flowlines and wells, consisting mainly of magnetite as the corrosion product, was further investigated with the objectives of explaining its formation...

  4. Optomechanical design of a high-precision detector robot arm system for x-ray nano-diffraction with x-ray nanoprobe

    Science.gov (United States)

    Shu, D.; Kalbfleisch, S.; Kearney, S.; Anton, J.; Chu, Y. S.

    2014-03-01

    Collaboration between Argonne National Laboratory and Brookhaven National Laboratory has created a design for the high-precision detector robot arm system that will be used in the x-ray nano-diffraction experimental station at the Hard X-ray Nanoprobe (HXN) beamline for the NSLS-II project. The robot arm system is designed for positioning and manipulating an x-ray detector in three-dimensional space for nano-diffraction data acquisition with the HXN x-ray microscope. It consists of the following major component groups: a granite base with air-bearing support, a 2-D horizontal base stage, a vertical axis goniometer, a 2-D vertical plane robot arm, a 3-D fast scanning stages group, and a 2-D x-ray pixel detector. The design specifications and unique optomechanical structure of this novel high-precision detector robot arm system will be presented in this paper.

  5. CRISPR-Cas systems exploit viral DNA injection to establish and maintain adaptive immunity.

    Science.gov (United States)

    Modell, Joshua W; Jiang, Wenyan; Marraffini, Luciano A

    2017-04-06

    Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems provide protection against viral and plasmid infection by capturing short DNA sequences from these invaders and integrating them into the CRISPR locus of the prokaryotic host. These sequences, known as spacers, are transcribed into short CRISPR RNA guides that specify the cleavage site of Cas nucleases in the genome of the invader. It is not known when spacer sequences are acquired during viral infection. Here, to investigate this, we tracked spacer acquisition in Staphylococcus aureus cells harbouring a type II CRISPR-Cas9 system after infection with the staphylococcal bacteriophage ϕ12. We found that new spacers were acquired immediately after infection preferentially from the cos site, the viral free DNA end that is first injected into the cell. Analysis of spacer acquisition after infection with mutant phages demonstrated that most spacers are acquired during DNA injection, but not during other stages of the viral cycle that produce free DNA ends, such as DNA replication or packaging. Finally, we showed that spacers acquired from early-injected genomic regions, which direct Cas9 cleavage of the viral DNA immediately after infection, provide better immunity than spacers acquired from late-injected regions. Our results reveal that CRISPR-Cas systems exploit the phage life cycle to generate a pattern of spacer acquisition that ensures a successful CRISPR immune response.

  6. [Clinical characteristics research of shenmai injection treating tumor based on hospital information system in real world].

    Science.gov (United States)

    Hu, Yuan-Chun; Xie, Yan-Ming; Yang, Wei; Wang, Yong-Yan; Wang, Lian-Xin; Tang, Hao; Zhuang, Yan

    2014-09-01

    The study was to research the clinical characteristics of Shenmai injection treating tumor based on hospital information system, including the characteristics of the age, the sex, the dosage, the course of the treatment and the combination drugs. The data of tumor patients injected with Shenmai injection was analyzed. The information was collected from the hospital information system (HIS) in twenty hospitals of grade III-A. The method of frequencies and association rules was used in this reaearch. The patients over 45 years old were up to 3 338, about 79.36% of the whole. The ratio of male and female was 1.73: 1. The hospitalization day between 15 and 28 was most. The complications of the hypertension and coronary heart disease happened most. The support was 5.939% and 5.099% respectively. Fifty-five patients had the traditional Chinese medicine (TCM) syndrome of Qi-Yin deficiency, about 14.78% of the whole. There were 8 491 patients treated with the single dose of 81 to 100 mL, about 48.70% of the whole. The main combination drugs were dexamethasone, tropisetron and maxolon. The confidence was 44.63%, 31.22% and 20.53% respectively. The information from HIS showed that tumor patients used Shenmai injection were most quinquagenarian with smooth condition. The dose of the Shenmai injection sometimes was higher than that of the drug use instructions in clinical. Shenmai injection was most often combined with glucocorticoid, antemetic and nutritional support medicine when treating tumor in clinical.

  7. Scaling of the direct ECC bypass during LBLOCA reflood phase with direct vessel injection system

    Energy Technology Data Exchange (ETDEWEB)

    Yun, B.J.; Kwon, T.S.; Song, C.H.; Jeong, J.J. [Korea Atomic Energy Research Inst., Taejon (Korea, Republic of); Cho, H.K.; Park, G.C. [Seoul National Univ., Dept. of Nuclear Engineering (Korea, Republic of)

    2001-07-01

    As one of the advanced design features of the Korea next generation reactor, direct vessel injection (DVI) system is being considered instead of conventional cold leg injection (CLI) system. It is known that the DVI system greatly enhances the reliability of the emergency core cooling (ECC) system. However, there is still a dispute on its performance in terms of water delivery to the reactor core during the reflood period of a large-break loss-of-coolant accident (LOCA). Thus, experimental validation is under progress. In this paper, a new scaling method, using time and velocity reduced linear scaling law, is suggested for the design of a scaled-down experimental facility to investigate the direct ECC bypass phenomena in PWR downcomer. (authors)

  8. Morphologic alterations in rat brain following systemic and intraventricular methotrexate injection: light and electron microscopic studies.

    Science.gov (United States)

    Gregorios, J B; Gregorios, A B; Mora, J; Marcillo, A; Fojaco, R M; Green, B

    1989-01-01

    To determine the morphological substrate of acute methotrexate (MTX) encephalopathy, light and electron microscopic studies were performed on rat brains after short-term intraperitoneal (IP) and intraventricular (IV) injections of MTX. In both models, Alzheimer type II astrocytosis was the initial and major pathologic alteration seen by light microscopy. The neurons, oligodendrocytes, myelin and endothelial cells were relatively spared. Ultrastructural studies showed pleomorphism and condensation of mitochondria, membrane-bound vacuoles, prominent stacks of sparsely granular, rough endoplasmic reticulum and progressive hydropic swelling of astrocytic perikarya and their processes. The astroglial alterations were reversible after cessation of the drug but persisted for a longer time with repeated IP administration. Gastrointestinal complications and overall mortality were also greater with higher doses and increasing frequency of IP MTX injection. White matter necrosis was noted only after IV injection of high-dose MTX. The neuropathologic changes of MTX leukoencephalopathy can be replicated in an animal model by IV injection of the drug. The reversibility of the changes that were seen following IP administration correlates with the transient neurologic deficits observed in some patients after high-dose systemic MTX therapy. The initially selective astroglial effect suggests that astrocytes might be a target for MTX toxicity, although other central nervous system components may also be adversely affected by the drug.

  9. Vertical migration of municipal wastewater in deep injection well systems, South Florida, USA

    Science.gov (United States)

    Maliva, Robert G.; Guo, Weixing; Missimer, Thomas

    2007-11-01

    Deep well injection is widely used in South Florida, USA for wastewater disposal largely because of the presence of an injection zone (“boulder zone” of Floridan Aquifer System) that is capable of accepting very large quantities of fluids, in some wells over 75,000 m3/day. The greatest potential risk to public health associated with deep injection wells in South Florida is vertical migration of wastewater, containing pathogenic microorganisms and pollutants, into brackish-water aquifer zones that are being used for alternative water-supply projects such as aquifer storage and recovery. Upwards migration of municipal wastewater has occurred in a minority of South Florida injection systems. The results of solute-transport modeling using the SEAWAT program indicate that the measured vertical hydraulic conductivities of the rock matrix would allow for only minimal vertical migration. Fracturing at some sites increased the equivalent average vertical hydraulic conductivity of confining zone strata by approximately four orders of magnitude and allowed for vertical migration rates of up 80 m/year. Even where vertical migration was rapid, the documented transit times are likely long enough for the inactivation of pathogenic microorganisms.

  10. Enzymatic Microreactors for the Determination of Ethanol by an Automatic Sequential Injection Analysis System

    Science.gov (United States)

    Alhadeff, Eliana M.; Salgado, Andrea M.; Cos, Oriol; Pereira, Nei; Valdman, Belkis; Valero, Francisco

    A sequential injection analysis system with two enzymatic microreactors for the determination of ethanol has been designed. Alcohol oxidase and horseradish peroxidase were separately immobilized on glass aminopropyl beads, and packed in 0.91-mL volume microreactors, working in line with the sequential injection analysis system. A stop flow of 120 s was selected for a linear ethanol range of 0.005-0.04 g/L±0.6% relative standard deviation with a throughput of seven analyses per hour. The system was applied to measure ethanol concentrations in samples of distilled and nondistilled alcoholic beverages, and of alcoholic fermentation with good performance and no significant difference compared with other analytical procedures (gas chromatography and high-performance liquid chromatography).

  11. Investigation of work parameters of SI engine dedicated to energetics aggregates with pneumatic injection system

    Science.gov (United States)

    Marek, W.; Śliwiński, K.

    2016-09-01

    The article presents the possibilities of alternative fuel combustion in the engine four- stroke spark ignition engines. Power of the motor was carried out pneumatic fuel injection system using a hot gas developed by Prof. Stanislaw Jarnuszkiewicz. Presented made the position of the measuring system with the power and results. The engine experimental at the time of the study was powered by a blend of alcohol and gasoline. The main aim of the study was the question of control fuel dosage, taking into account the energy needs of forcing the engine load. During the tests carried load characteristics control the motor using the power control quality. Another issue was the elimination of penetration of fuel to the engine lubrication system, a problem occurred in the initial study on the issue of the pneumatic fuel injection using the hot exhaust gases. In summary we present the findings of this phase of the study.

  12. Reactive Power Injection Strategies for Single-Phase Photovoltaic Systems Considering Grid Requirements

    DEFF Research Database (Denmark)

    Yang, Yongheng; Wang, Huai; Blaabjerg, Frede

    2014-01-01

    like what the conventional power plants do today in the grid regulation participation. Requirements of ancillary services like Low-Voltage Ride-Through (LVRT) associated with reactive current injection and voltage support through reactive power control, have been in effectiveness in some countries...... possibilities are: a) constant average active power control, b) constant active current control, c) constant peak current control and d) thermal optimized control strategy. All those strategies comply with the currently active grid codes, but are with different objectives. The thermal optimized control strategy....... Those advanced features can be provided by next-generation PV systems, and will be enhanced in the future to ensure an even efficient and reliable utilization of PV systems. In the light of this, Reactive Power Injection (RPI) strategies for single-phase PV systems are explored in this paper. The RPI...

  13. Reactive Power Injection Strategies for Single-Phase Photovoltaic Systems Considering Grid Requirements

    DEFF Research Database (Denmark)

    Yang, Yongheng; Wang, Huai; Blaabjerg, Frede

    2014-01-01

    like what the conventional power plants do today in the grid regulation participation. Requirements of ancillary services like Low-Voltage Ride-Through (LVRT) associated with reactive current injection and voltage support through reactive power control, have been in effectiveness in some countries, e...... in this paper. The RPI possibilities are: a) constant average active power control, b) constant active current control, c) constant peak current control and d) thermal optimized control strategy. All those strategies comply with the currently active grid codes, but are with different objectives. The proposed.......g. Germany and Italy. Those advanced features can be provided by next generation PV systems, and will be enhanced in the future to ensure an even efficient and reliable utilization of PV systems. In light of this, Reactive Power Injection (RPI) strategies for single-phase PV systems are explored...

  14. Time trend of injection drug errors before and after implementation of bar-code verification system.

    Science.gov (United States)

    Sakushima, Ken; Umeki, Reona; Endoh, Akira; Ito, Yoichi M; Nasuhara, Yasuyuki

    2015-01-01

    Bar-code technology, used for verification of patients and their medication, could prevent medication errors in clinical practice. Retrospective analysis of electronically stored medical error reports was conducted in a university hospital. The number of reported medication errors of injected drugs, including wrong drug administration and administration to the wrong patient, was compared before and after implementation of the bar-code verification system for inpatient care. A total of 2867 error reports associated with injection drugs were extracted. Wrong patient errors decreased significantly after implementation of the bar-code verification system (17.4/year vs. 4.5/year, pcode medication administration is effective for prevention of wrong patient errors. However, ordinary bar-code verification systems are limited in their ability to prevent incorrect drug preparation in hospital wards.

  15. A hybrid WDM transport system based on mutually injection-locked Fabry Perot laser diodes

    Science.gov (United States)

    Ying, Cheng-Ling; Lu, Hai-Han; Tzeng, Shah-Jye; Ma, Hsien-Li; Chuang, Yao-Wei

    2007-08-01

    A hybrid wavelength-division-multiplexing (WDM) transport system based on mutually injection-locked Fabry-Perot laser diodes (FP LDs) for CATV, 256-QAM and OC-48 transmission is proposed and demonstrated. Mutually injection-locked FP LDs as broadband light source could be relatively simple and cost-effective compared with other demonstrated light source schemes. The proposed hybrid WDM transport system employs four filtered wavelengths (modes) to transmit 111 AM-VSB channels, four 256-QAM digital passband channels, and one OC-48 digital baseband channel simultaneously. Since our proposed system does not use multiple distributed feedback (DFB) LDs, it reveals a prominent one with simpler and more economic advantages.

  16. Delivery of erythropoietin with a needleless injection system during hemodialysis maintains plasma levels.

    Science.gov (United States)

    Petersen, J; Jani, A

    2001-01-01

    Recent Occupational Safety and Health Administration guidelines require the implementation of needleless systems in dialysis units in the state of California. It is not known whether needleless systems deliver medication as well as traditional low dead-space needle/syringes. The purpose of this study was to compare the delivery of recombinant human erythropoietin (rHuEpo) by a needleless system (Medic Plastic Anti-Stick Needle/Connector, Medisystems, Seattle, WA) with delivery using a traditional low dead-space needle/syringe. We also studied the Medisystems High Flow venous chamber with integral injection site that is designed to prevent the formation of a separate serum layer within which rHuEpo may become trapped. There was no significant difference in the mean serum rHuEpo concentration achieved by either the needleless system, or traditional low dead-space needle/syringe, whether using the venous chamber's integral injection site or the postvenous chamber in-line injection site. This study demonstrates for the first time that a needleless system of delivery can reliably achieve serum rHuEpo comparable to traditional low dead-space needle/syringes.

  17. Simulation of chaotic synchronization communication system based on incoherent optical feedback and injection

    Institute of Scientific and Technical Information of China (English)

    MA Jun-shan; GU Wen-hua

    2006-01-01

    In this paper,we numerically study chaotic synchronization communication system based on incoherent optical feedback and incoherent optical injection.The characteristics of the system,such as synchronization time,synchronization error,chaos shift keying encoding/decoding and modulation rate are analyzed.The results of simulation show that the system has good synchronization quality and good abilities of robust secure.The synchronization time is 1ns and the chaos shift keying encoding can reach a high rate of 1 Gbit/s.The system has a good ability of robust secure.It proves the feasibility of the optical secure communication.

  18. Installation, maintenance and operating manual for the Lucas-type fuel injection system of the 3 B rotary engine

    Science.gov (United States)

    1985-01-01

    The installation procedure, maintenance, adjustment and operation of a Lucas type fuel injection system for 13B rotary racing engine is outlined. Components of the fuel injection system and installation procedure and notes are described. Maintenance, adjustment, and operation are discussed.

  19. Refurbishment of a used in-vacuum undulator from the National Synchrotron Light Source for the National Synchrotron Light Source-II ring.

    Science.gov (United States)

    Tanabe, Toshiya; Bassan, Harmanpreet; Broadbent, Andrew; Cappadoro, Peter; Escallier, John; Harder, David; Hetzel, Charles; Hidas, Dean; Kitegi, Charles; Kosciuk, Bernard; Musardo, Marco; Kirkland, Johnny

    2017-09-01

    The National Synchrotron Light Source (NSLS) ceased operation in September 2014 and was succeeded by NSLS-II. There were four in-vacuum undulators (IVUs) in operation at NSLS. The most recently constructed IVU for NSLS was the mini-gap undulator (MGU-X25, to be renamed IVU18 for NSLS-II), which was constructed in 2006. This device was selected to be reused for the New York Structural Biology Consortium Microdiffraction beamline at NSLS-II. At the time of construction, IVU18 was a state-of-the-art undulator designed to be operated as a cryogenic permanent-magnet undulator. Due to the more stringent field quality and impedance requirements of the NSLS-II ring, the transition region was redesigned. The control system was also updated to NSLS-II specifications. This paper reports the details of the IVU18 refurbishment activities including additional magnetic measurement and tuning.

  20. Two-phase Flow of Liquid-gas in Diesel Fuel Injection System and Their Effect on Engine Performances

    Institute of Scientific and Technical Information of China (English)

    Yongling He; Zhihe Zhao; Jianxin Liu; Huiyong Du; Min Li; Yongping Zong

    2001-01-01

    In this paper, by using high-speed camera, CCD camera, signal and graph acquisition system, and other experimental instruments, investigation on liquid-gas two-phase flow in diesel fuel injection system and their effect on engine performances were made. Emerging and bursting of cavitation in the cavity above pump delivery valve, in injection pipe, and in fuel trough of injector of the fuel injection system were observed and mechanism of cavitation were discussed. Effects of liquid-gas two-phase flow on propagation velocity of pressure wave of the system and on irregular injection were analyzed. Two types of cavitation, long living time cavitation and short living time cavitation, in the cavity above pump delivery valve of diesel fuel injection system were observed.

  1. Production and quality assurance of bright steel products for high performance components in fuel injection systems

    Energy Technology Data Exchange (ETDEWEB)

    Janssen, P.; Bodenstein, F. [Mittal Steel Ruhrort GmbH, Duisburg (Germany); Engineer, S. [EZM Edelstahlzieherei Mark, Wetter (Germany)

    2005-07-01

    In the last years the demands on the technological properties of steels in fuel injection systems are constantly increasing. There has been for instance a significant increase in the pressure of fuel injections systems. This means even small imperfections in steels can lead to field failures. The grades 47Pb2 and 42CrMo4 for fuel injection systems have stringent requirements regarding the production and application of the components. In order to obtain the best possible quality all stages of the production system have to be monitored very carefully. The steel making process in the steel plant has to follow strict rules to avoid detrimental oxide inclusions, reduce segregation, improve lead distribution, provide a good surface quality and homogeneous structure. The process of manufacturing bright steel bars from the hot rolled wire rods also involves capable processes with intensive 100% testing of all the bars supplied to the customer. The wire rods are drawn to bars and ground to narrow tolerances. The bars undergo an eddy current test to determine surface defects and also a sophisticated ultra sonic test at a flat bottom hole of 0.7. In spite of all the process monitoring and tests carried out from the melting up to grinding the bars there is still a chance of certain imperfection or defects remaining on the bars, which are more likely detectable on processing the bars to components. Therefore is also a necessity to carry out a test during the stage of component manufacturing. (orig.)

  2. Injectable nanoparticle-loaded hydrogel system for local delivery of sodium alendronate.

    Science.gov (United States)

    Posadowska, Urszula; Parizek, Martin; Filova, Elena; Wlodarczyk-Biegun, Malgorzata; Kamperman, Marleen; Bacakova, Lucie; Pamula, Elzbieta

    2015-05-15

    Systemic administration of bisphosphonates, e.g. sodium alendronate (Aln) is characterized by extremely low bioavailability and high toxicity. To omit aforementioned drawbacks an injectable system for the intra-bone delivery of Aln based on Aln-loaded nanoparticles (NPs-Aln) suspended in a hydrogel matrix (gellan gum, GG) was developed. Aln was encapsulated in poly(lactide-co-glycolide) (PLGA 85:15) by solid-oil-water emulsification. Drug release tests showed that within 25 days all the encapsulated drug was released from NPs-Aln and the release rate was highest at the beginning and decreased with time. In contrast, by suspending NPs-Aln in a GG matrix, the release rate was significantly lower and more constant in time. The GG-NPs-Aln system was engineered to be easily injectable and was able to reassemble its structure after extrusion as shown by rheological measurements. Invitro studies showed that the GG-NPs-Aln was cytocompatible with MG-63 osteoblast-like cells and it inhibited RANKL-mediated osteoclastic differentiation of RAW 264.7 cells. The injectability, the sustained local delivery of small doses of Aln and the biological activity render the GG-NPs-Aln system promising for the local treatment of osteoporosis and other bone tissue disorders.

  3. Design optimisation of a nanofluid injection system for LOCA events in a nuclear power plant

    Science.gov (United States)

    Călimănescu, I.; Stan, L. C.; Velcea, D. D.

    2016-08-01

    The safety issues inside a Nuclear Power Plant (NPP) are encompassing their capacity to ensure the heat sink, meaning the capacity of the systems to release the heat from the rector to the environment. The nanofluids having good heat transfer properties, are recommended to be used in such applications. The paper is solving the following scenario: considering the Safety Injection tank and the Nanofluid injection Tank, and considering the Nanofluid injection Tank filled with a 10% alumina-water nanofluid, how can we select the best design of the connecting point between the pipes of the SIT and the Nanofluid Tank and the pressures inside of any of these tanks in order to have the biggest density of nanoparticles leaving the tanks toward the cold leg. In conclusion the biggest influence over the rate of disposal of the nanofluid inside ECCS is that of the pressure inside the SIT followed in order by the injection pipe diameter and the pressure inside the nanofluid tank. The optimum balance of these three design parameters may be reached following the procedure shown in this paper.

  4. Nuclear Safety Functions of ITER Gas Injection System Instrumentation and Control and the Concept Design

    Science.gov (United States)

    Yang, Yu; Maruyama, S.; Fossen, A.; Villers, F.; Kiss, G.; Zhang, Bo; Li, Bo; Jiang, Tao; Huang, Xiangmei

    2016-08-01

    The ITER Gas Injection System (GIS) plays an important role on fueling, wall conditioning and distribution for plasma operation. Besides that, to support the safety function of ITER, GIS needs to implement three nuclear safety Instrumentation and Control (I&C) functions. In this paper, these three functions are introduced with the emphasis on their latest safety classifications. The nuclear I&C design concept is briefly discussed at the end.

  5. Determination of Ciprofloxacin by Flow Injection Analysis Based on Chemiluminescence System

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    A novel flow injection chemiluminescence (CL) method for the determination of ciprofloxacin (CPLX) was reported. The proposed method is based on luminescence produced by KMnO4-Na2S2O4-Tb3+-CPLX chemiluminescence (CL) system. The effects of some critical experimental conditions were discussed and the optimization of working condithe recoveries of real sample analyses were in the range from 110 ± 4 to 104 ± 4.

  6. A lactose flow injection analysis biosensor system for monitoring and process control

    OpenAIRE

    2004-01-01

    In this work an enzymatic lactose biosensor composed of the immobilized enzymes E- galactosidase and glucose oxidase was developed. Oxygen consumption during the reaction catalyzed by these enzymes was detected. The biosensor was integrated into an FIA (flow injection analysis) system that allows measurement of lactose on-line in less than three minutes. This biosensor was used to monitor lactose concentration during the production of E-galactosidase by the yeast Kluyveromyces marxianus from ...

  7. Potentiometric electronic tongue-flow injection analysis system for the monitoring of heavy metal biosorption processes.

    Science.gov (United States)

    Wilson, D; del Valle, M; Alegret, S; Valderrama, C; Florido, A

    2012-05-15

    An automated flow injection potentiometric (FIP) system with electronic tongue detection (ET) is used for the monitoring of biosorption processes of heavy metals on vegetable wastes. Grape stalk wastes are used as biosorbent to remove Cu(2+) ions in a fixed-bed column configuration. The ET is formed by a 5-sensor array with Cu(2+) and Ca(2+)-selective electrodes and electrodes with generic response to heavy-metals, plus an artificial neural network response model of the sensor's cross-response. The real-time monitoring of both the Cu(2+) and the cation exchanged and released (Ca(2+)) in the effluent solution is performed by using flow-injection potentiometric electronic tongue system. The coupling of the electronic tongue with automation features of the flow-injection system allows us to accurately characterize the Cu(2+) ion-biosorption process, through obtaining its breakthrough curves, and the profile of the Ca(2+) ion release. In parallel, fractions of the extract solution are analysed by spectroscopic techniques in order to validate the results obtained with the reported methodology. The sorption performance of grape stalks is also evaluated by means of well-established sorption models.

  8. Road Maintenance Experience Using Polyurethane (PU) Foam Injection System and Geocrete Soil Stabilization as Ground Rehabilitation

    Science.gov (United States)

    Fakhar, A. M. M.; Asmaniza, A.

    2016-07-01

    There are many types of ground rehabilation and improvement that can be consider and implement in engineering construction works for soil improvement in order to prevent road profile deformation in later stage. However, when comes to road maintenance especially on operated expressways, not all method can be apply directly as it must comply to opreation's working window and lane closure basis. Key factors that considering ideal proposal for ground rehabilitation are time, cost, quality and most importantly practicality. It should provide long lifespan structure in order to reduce continuous cycle of maintenance. Thus, this paper will present two approaches for ground rehabilitation, namely Polyurethane (PU) Foam Injection System and Geocrete Soil Stabilization. The first approach is an injection system which consists two-parts chemical grout of Isocynate and Polyol when mixed together within soil structure through injection will polymerized with volume expansion. The strong expansion of grouting causes significant compression and compacting of the surrounding soil and subsequently improve ground properties and uplift sunken structure. The later is a cold in-place recyclying whereby mixture process that combines in-situ soil materials, cement, white powder (alkaline) additive and water to produce hard yet flexible and durable ground layer that act as solid foundation with improved bearing capacity. The improvement of the mechanical behaviour of soil through these two systems is investigated by an extensive testing programme which includes in-situ and laboratory test in determining properties such as strength, stiffness, compressibility, bearing capacity, differential settlement and etc.

  9. The regulatory system for diabetes mellitus: Modeling rates of glucose infusions and insulin injections

    Science.gov (United States)

    Yang, Jin; Tang, Sanyi; Cheke, Robert A.

    2016-08-01

    Novel mathematical models with open and closed-loop control for type 1 or type 2 diabetes mellitus were developed to improve understanding of the glucose-insulin regulatory system. A hybrid impulsive glucose-insulin model with different frequencies of glucose infusions and insulin injections was analyzed, and the existence and uniqueness of the positive periodic solution for type 1 diabetes, which is globally asymptotically stable, was studied analytically. Moreover, permanence of the system for type 2 diabetes was demonstrated which showed that the glucose concentration level is uniformly bounded above and below. To investigate how to prevent hyperinsulinemia and hyperglycemia being caused by this system, we developed a model involving periodic intakes of glucose with insulin injections applied only when the blood glucose level reached a given critical glucose threshold. In addition, our numerical analysis revealed that the period, the frequency and the dose of glucose infusions and insulin injections are crucial for insulin therapies, and the results provide clinical strategies for insulin-administration practices.

  10. Effect of semiconductor-controlled voltage injection by UPFC and ULTC on power system stability

    Science.gov (United States)

    Alavian Mehr, Alireza

    Commercial availability of various power semiconductor switches indicates proliferation of power electronic based apparatus in utility power systems. Furthermore, existing power system apparatus, e.g. mechanical phase shifters and mechanical tap changing transformers, will be retrofitted to utilize higher switching speed of semiconductor switches. A group of these apparatus, i.e., unified power flow controller (UPFC), static phase shifter (SPS), under-load tap-changing (ULTC) transformer and static series capacitor (SSC), perform their respective functions by means of injecting series controlled voltages in power systems. This thesis demonstrates that fast series voltage injection, for dynamic power flow regulation, can result in voltage dynamics and even voltage instability. This indicates that fast voltage injection by means of power electronic based apparatus can couple voltage stability and angle stability phenomena. To investigate this coupling phenomena, the voltage dependency of the load must be adequately represented in the load model. The reported studies in this work are based on representing the load by a combination of static and dynamic loads. This thesis primarily investigates impacts of UPFC and semiconductor-controlled ULTC on voltage stability and angle stability phenomena. An eigen analysis approach is used for the studies. The eigen analysis results are validated by digital time-domain simulations using a transient stability software. Both the eigen analysis and the transient stability software tools are tailored to account for angle and voltage stability phenomena.

  11. Local and systemic toxicity of intraoral submucosal injections of phentolamine mesylate (OraVerse).

    Science.gov (United States)

    Rutherford, Bruce; Zeller, Jillynne R; Thake, Daryl

    2009-01-01

    OraVerse, an injectable formulation of phentolamine mesylate (PM), was recently approved by the U.S. Food and Drug Administration (FDA) for reversal of anesthesia of the lip and tongue and associated functional deficits resulting from an intraoral submucosal injection of a local anesthetic containing a vasoconstrictor. Because PM had not been approved previously for submucosal administration, 2 Good Laboratory Practices (GLP) studies in dogs designed to investigate systemic toxicity and the local effects of single and repeated dosing of OraVerse on the inferior alveolar nerve and branches of the superior alveolar nerve and adjacent soft tissues after local administration were conducted. Systemic toxicity was measured by preinjection and postinjection clinical examinations, clinical chemistry, and gross and microscopic examinations of major organs after necropsy. No evidence of systemic toxicity was detected. Local nerve and adjacent tissue damage was assessed by conventional histopathology. Nerve degeneration was evident in 1 animal. Mild perineural inflammation adjacent to the inferior alveolar nerve and inflammatory exudates were observed in submucosal tissues in several animals. No changes were observed in the nerves at injection sites of dogs from any dose group that were considered directly related to the test articles. These data reveal that single and repeated intraoral administrations of OraVerse are well tolerated in beagle dogs.

  12. A Review of Injectable Polymeric Hydrogel Systems for Application in Bone Tissue Engineering.

    Science.gov (United States)

    Kondiah, Pariksha J; Choonara, Yahya E; Kondiah, Pierre P D; Marimuthu, Thashree; Kumar, Pradeep; du Toit, Lisa C; Pillay, Viness

    2016-11-21

    Biodegradable, stimuli-responsive polymers are essential platforms in the field of drug delivery and injectable biomaterials for application of bone tissue engineering. Various thermo-responsive hydrogels display water-based homogenous properties to encapsulate, manipulate and transfer its contents to the surrounding tissue, in the least invasive manner. The success of bioengineered injectable tissue modified delivery systems depends significantly on their chemical, physical and biological properties. Irrespective of shape and defect geometry, injectable therapy has an unparalleled advantage in which intricate therapy sites can be effortlessly targeted with minimally invasive procedures. Using material testing, it was found that properties of stimuli-responsive hydrogel systems enhance cellular responses and cell distribution at any site prior to the transitional phase leading to gelation. The substantially hydrated nature allows significant simulation of the extracellular matrix (ECM), due to its similar structural properties. Significant current research strategies have been identified and reported to date by various institutions, with particular attention to thermo-responsive hydrogel delivery systems, and their pertinent focus for bone tissue engineering. Research on future perspective studies which have been proposed for evaluation, have also been reported in this review, directing considerable attention to the modification of delivering natural and synthetic polymers, to improve their biocompatibility and mechanical properties.

  13. Development of mediated BOD biosensor system of flow injection mode for shochu distillery wastewater.

    Science.gov (United States)

    Oota, Shinichi; Hatae, Yuta; Amada, Kei; Koya, Hidekazu; Kawakami, Mitsuyasu

    2010-09-15

    Although microbial biochemical oxygen demand (BOD) sensors utilizing redox mediators have attracted much attention as a rapid BOD measurement method, little attempts have been made to apply the mediated BOD biosensors to the flow injection analysis system. In this work, a mediated BOD sensor system of flow injection mode, constructed by combining an immobilized microbial reactor with an electrochemical flow cell of three electrodes configuration, has been developed to estimate BOD of shochu distillery wastewater (SDW). It was demonstrated consequently that the mediated sensing was realized by employing phosphate buffer containing potassium hexacyanoferrate as the carrier. The output current was found to yield a peak with a sample injection, and to result from reoxidation of reduced mediator at the electrode. By employing the peak area as the sensor response, the effects of flow rate and pH of the carrier on the sensitivity were investigated. The sensor system using a microorganism of high SDW-assimilation capacity showed good performance and proved to be available for estimation of BOD of SDW.

  14. A versatile and reproducible automatic injection system for liquid standard introduction: application to in-situ calibration

    Directory of Open Access Journals (Sweden)

    G. Isaacman

    2011-05-01

    Full Text Available The quantitation of trace organic compounds in ambient organic aerosol is difficult due to the chemical complexity of these mixtures, but is needed to provide insight into their sources and formation processes. Compound-level characterization of organic aerosols is typically performed through sample collection followed by gas or liquid chromatography. With these methods, introduction of liquid standards has long been used as an effective means of quantifying trace compounds, but automating this technique for use with in-situ instrumentation has not previously been achieved. Here we develop an automatic injection system (AutoInject for the introduction of liquids into a custom collection and analysis cell for improved quantitation in chromatographic measurements. The system consists of chilled reservoirs containing liquid standards from which a sample loop is loaded and then injected into the cell. The AutoInject is shown to have reproducibility over 106 injections with a relative standard deviation of 1.5 %, and have negligible injection-to-injection carryover. A 6-port selector allows injection of different liquid standards separately or simultaneously. Additionally, automatic injection of multiple sample loops is shown to generate a linear multi-point calibration curve. Tests conducted in this work focus on use with the Thermal desorption Aerosol Gas chromatograph (TAG, but the flexibility of the system allows it to be used for a variety of applications.

  15. Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users.

    Directory of Open Access Journals (Sweden)

    Michael S Piepenbrink

    Full Text Available Injection drug use is a growing major public health concern. Injection drug users (IDUs have a higher incidence of co-morbidities including HIV, Hepatitis, and other infections. An effective humoral response is critical for optimal homeostasis and protection from infection; however, the impact of injection heroin use on humoral immunity is poorly understood. We hypothesized that IDUs have altered B cell and antibody profiles.A comprehensive systems biology-based cross-sectional assessment of 130 peripheral blood B cell flow cytometry- and plasma- based features was performed on HIV-/Hepatitis C-, active heroin IDUs who participated in a syringe exchange program (n = 19 and healthy control subjects (n = 19. The IDU group had substantial polydrug use, with 89% reporting cocaine injection within the preceding month. IDUs exhibited a significant, 2-fold increase in total B cells compared to healthy subjects, which was associated with increased activated B cell subsets. Although plasma total IgG titers were similar between groups, IDUs had significantly higher IgG3 and IgG4, suggestive of chronic B cell activation. Total IgM was also increased in IDUs, as well as HIV Envelope-specific IgM, suggestive of increased HIV exposure. IDUs exhibited numerous features suggestive of systemic inflammation, including significantly increased plasma sCD40L, TNF-α, TGF-α, IL-8, and ceramide metabolites. Machine learning multivariate analysis distilled a set of 10 features that classified samples based on group with absolute accuracy.These results demonstrate broad alterations in the steady-state humoral profile of IDUs that are associated with increased systemic inflammation. Such dysregulation may impact the ability of IDUs to generate optimal responses to vaccination and infection, or lead to increased risk for inflammation-related co-morbidities, and should be considered when developing immune-based interventions for this growing population.

  16. Simple flow injection colorimetric system for determination of paraquat in natural water.

    Science.gov (United States)

    Chuntib, Prakit; Jakmunee, Jaroon

    2015-11-01

    A simple and low cost flow injection colorimetric system has been developed for determination of paraquat in natural water. The developed method is based on the reduction of paraquat by using sodium dithionite as a reducing agent in an alkaline medium to produce a blue free radical ion that can be detected by a simple light emitting diode-light dependent resistor (LED-LDR) colorimeter. The standard or sample solution was injected via a set of 3-way solenoid valves into a water carrier stream and flowed to merge with reagent to generate a colored product which is proportional to the concentration of paraquat ion in the solution. Under the optimum condition of the system, i.e., mixing coil length 30 cm, flow rate 2.0 mL min(-1), sample volume 100 μL, concentrations of dithionite 0.1% (w/v) and sodium hydroxide 0.06 mol L(-1), a linear calibration graph in the range of 0.2-10.0 mg L(-1) with a correlation coefficient of 0.9996, and a limit of detection of 0.15 mg L(-1) were achieved. Relative standard deviation for 9 replicate injections of 1 mg L(-1) paraquat is 3.7%. A sample throughput of 40 injections h(-1) was achieved. The limit of detection can be improved by off-line preconcentration of paraquat employing a column packed with Dowex 50WX8-100 (H) cation exchange resin and eluted with 10% (w/v) ammonium chloride in ammonium buffer solution pH 10. The eluting solution was then injected into the FI system for paraquat determination. The proposed system did not suffer from interferences of some possible ions in natural water and other herbicides. Recoveries obtained by spiking 0.5 and 5.0 mg L(-1) paraquat standard into water samples were in the range of 104-110% and 101-105%, respectively. The developed system can be conveniently applied for screening of paraquat contaminated in natural water.

  17. Development of a novel injectable drug delivery system for subconjunctival glaucoma treatment.

    Science.gov (United States)

    Voss, Karsten; Falke, Karen; Bernsdorf, Arne; Grabow, Niels; Kastner, Christian; Sternberg, Katrin; Minrath, Ingo; Eickner, Thomas; Wree, Andreas; Schmitz, Klaus-Peter; Guthoff, Rudolf; Witt, Martin; Hovakimyan, Marina

    2015-09-28

    In this study we present the development of an injectable polymeric drug delivery system for subconjunctival treatment of primary open angle glaucoma. The system consists of hyaluronic acid sodium salt (HA), which is commonly used in ophthalmology in anterior segment surgery, and an isocyanate-functionalized 1,2-ethylene glycol bis(dilactic acid) (ELA-NCO). The polymer mixtures with different ratios of HA to ELA-NCO (1/1, 1/4, and 1/10 (v/v)) were investigated for biocompatibility, degradation behavior and applicability as a sustained release system. For the latter, the lipophilic latanoprost ester pro-drug (LA) was incorporated into the HA/ELA-NCO system. In vitro, a sustained LA release over a period of about 60days was achieved. In cell culture experiments, the HA/ELA-NCO (1/1, (v/v)) system was proven to be biocompatible for human and rabbit Tenon's fibroblasts. Examination of in vitro degradation behavior revealed a total mass loss of more than 60% during the observation period of 26weeks. In vivo, LA was continuously released for 152days into rabbit aqueous humor and serum. Histological investigations revealed a marked leuko-lymphocytic infiltration soon after subconjunctival injection. Thereafter, the initial tissue reaction declined concomitantly with a continuous degradation of the polymer, which was completed after 10months. Our study demonstrates the suitability of the polymer resulting from the reaction of HA with ELA-NCO as an injectable local drug delivery system for glaucoma therapy, combining biocompatibility and biodegradability with prolonged drug release.

  18. Simulation model for jet flow in liquid injection system of CANDU-6 SDS 2

    Energy Technology Data Exchange (ETDEWEB)

    Che, K. M.; Yoo, S. Y. [Chungnam National Univ., Taejon (Korea, Republic of); Lee, B. W.; Choi, H. B. [KAERI, Taejon (Korea, Republic of)

    2000-10-01

    For the performance analysis of the secondary shutdown system (SDS-2), a computational fluid dynamics (CFD) model for the poison jet flow is being developed to analyze the flow and poison concentration fields formed inside the moderator tank. As the ratio between Calandria shell and the nozzle hole diameter of the injection system is so big as 1055, it is impractical to develop a full size model encompassing the whole Calandria tank. To reduce the model to a manageable size, a quarter of the five-lattice-pitch length segment of the tank was modeled by using the symmetric nature of the jet and the injected jet was treated as source term to remove the limit caused by the small diameter of the injection nozzle hole, when the grid of the calculation domain was generated. A half model calculation was performed to show the symmetricity of the quarter model. For the validation of the source treatment of the inlet flow condition, the simulation result was compared with the experimental data of the gas jet. The symmetricity was confirmed by the results of simulation the half model calculation on the symmetric line and the result of simulation for the source treatment well agreed with the experiment when a fine mesh grid structure was used near the inlet.

  19. Effectiveness of surface aeration and oxygen injection system in the Athabasca River

    Energy Technology Data Exchange (ETDEWEB)

    Lima-Neto, I.E.; Zhu, D.Z.; Rajaratnam, N.; Yu, T. [Alberta Univ., Edmonton, AB (Canada). Dept. of Chemical and Materials Engineering; Spafford, M. [Alberta-Pacific Forest Industries Ltd. Boyle, AB (Canada); McEachern, P. [Alberta Environment, AB (Canada)

    2005-07-01

    The effectiveness of a pilot oxygen injection program and surface aeration at the open-water lead downstream of the Al-Pac's effluent diffuser was evaluated in this abstract. Dissolved oxygen (DO) is regarded as a proxy for the overall health of a river from the perspectives of organic and nutrient loading. When organic loading is high and DO concentrations become a concern, a mitigation option may be necessary. In this experiment, a modified Streeter-Phelps model described the spatial variation of DO downstream of the diffuser. Reaeration from the open water lead, formed as a result of effluent temperature, was significant. This suggested the importance of accurate prediction of the water lead's size in managing effluent effects. The amount of DO added to the river due to artificial aeration at rates of 3500 and 5000 lbs per day was approximately 55 and 27 per cent of that due to surface reaeration of a 4 and 5 km long open water lead, respectively. The artificial aeration technique evaluated appeared to have higher absorption efficiencies than those for conventional air injection systems. It was concluded that the results of this study will be valuable for future development of accurate DO models for ice-covered rivers as well as in developing and evaluating oxygen injection systems. tabs, figs.

  20. Fault Injection and Monitoring Capability for a Fault-Tolerant Distributed Computation System

    Science.gov (United States)

    Torres-Pomales, Wilfredo; Yates, Amy M.; Malekpour, Mahyar R.

    2010-01-01

    The Configurable Fault-Injection and Monitoring System (CFIMS) is intended for the experimental characterization of effects caused by a variety of adverse conditions on a distributed computation system running flight control applications. A product of research collaboration between NASA Langley Research Center and Old Dominion University, the CFIMS is the main research tool for generating actual fault response data with which to develop and validate analytical performance models and design methodologies for the mitigation of fault effects in distributed flight control systems. Rather than a fixed design solution, the CFIMS is a flexible system that enables the systematic exploration of the problem space and can be adapted to meet the evolving needs of the research. The CFIMS has the capabilities of system-under-test (SUT) functional stimulus generation, fault injection and state monitoring, all of which are supported by a configuration capability for setting up the system as desired for a particular experiment. This report summarizes the work accomplished so far in the development of the CFIMS concept and documents the first design realization.

  1. BLAST FURNACE GRANULAR COAL INJECTION SYSTEM. Final Report Volume 2: Project Performance and Economics

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    1999-10-01

    Bethlehem Steel Corporation (BSC) requested financial assistance from the Department of Energy (DOE), for the design, construction and operation of a 2,800-ton-per-day blast furnace granulated coal injection (BFGCI) system for two existing iron-making blast furnaces. The blast furnaces are located at BSC's facilities in Burns Harbor, Indiana. The demonstration project proposal was selected by the DOE and awarded to Bethlehem in November 1990. The design of the project was completed in December 1993 and construction was completed in January 1995. The equipment startup period continued to November 1995 at which time the operating and testing program began. The blast furnace test program with different injected coals was completed in December 1998.

  2. Generators and automated generator systems for production and on-line injections of pet radiopharmaceuticals

    Science.gov (United States)

    Shimchuk, G.; Shimchuk, Gr; Pakhomov, G.; Avalishvili, G.; Zavrazhnov, G.; Polonsky-Byslaev, I.; Fedotov, A.; Polozov, P.

    2017-01-01

    One of the prospective directions of PET development is using generator positron radiating nuclides [1,2]. Introduction of this technology is financially promising, since it does not require expensive special accelerator and radiochemical laboratory in the medical institution, which considerably reduces costs of PET diagnostics and makes it available to more patients. POZITOM-PRO RPC LLC developed and produced an 82Sr-82Rb generator, an automated injection system, designed for automatic and fully-controlled injections of 82RbCl produced by this generator, automated radiopharmaceutical synthesis units based on generated 68Ga produced using a domestically-manufactured 68Ge-68Ga generator for preparing two pharmaceuticals: Ga-68-DOTA-TATE and Vascular Ga-68.

  3. Design of Control Server Application Software for Neutral Beam Injection System

    Institute of Scientific and Technical Information of China (English)

    施齐林; 胡纯栋; 盛鹏; 宋士化

    2012-01-01

    For the remote control of a neutral beam injection (NBI) system, a software NBIcsw is developed to work on the control server. It can meet the requirements of data transmission and operation-control between the NBI measurement and control layer (MCL) and the remote monitoring layer (RML). The NBIcsw runs on a Linux system, developed with client/server (C/S) mode and multithreading technology. It is shown through application that the software is with good efficiency.

  4. Analysis on Pressure Distribution in HT-7 Neutral Beam Injection System

    Institute of Scientific and Technical Information of China (English)

    Zhu Wu; Chen Lian; Hu Chundong; Hu Liqun

    2005-01-01

    Neutral Beam Injection. (NBI) is an effective way to improve the efficiency of tokamak heating system. This article primarily introduces a work on the pressure distribution inside the tank of NBI heating system, especially inside the neutralizer, which is got by selecting a proper mathematical model and constructing a series of rational calculating formulas on pressure distribution. Furthermore, we simulate the pressure distribution by the Monte Carlo method. Comparing the result of simulation with that of theoretical calculation, we find that both the results are very close each other, showing their mutual validity.

  5. Solid state generator for powerful radio frequency ion sources in neutral beam injection systems

    Energy Technology Data Exchange (ETDEWEB)

    Kraus, W.; Fantz, U.; Heinemann, B.; Franzen, P.

    2015-02-15

    Radio frequency ion sources used in neutral beam injection systems (NBI) of fusion machines are currently supplied by self-excited RF generators. These generators have both a low power efficiency and a limited frequency stability, therefore transistorized amplifiers are being considered for the power supply of the next generation of RF sources. A 75 kW generator, originally designed for broadcasting, has been tested with a negative ion source. High operational reliability and a very good matching to the plasma load has been demonstrated. These results make this generator type a very promising candidate for future NBI systems.

  6. Li-ion battery thermal runaway suppression system using microchannel coolers and refrigerant injections

    Science.gov (United States)

    Bandhauer, Todd M.; Farmer, Joseph C.

    2016-11-08

    A battery management system with thermally integrated fire suppression includes a multiplicity of individual battery cells in a housing; a multiplicity of cooling passages in the housing within or between the multiplicity of individual battery cells; a multiplicity of sensors operably connected to the individual battery cells, the sensors adapted to detect a thermal runaway event related to one or more of the multiplicity of individual battery cells; and a management system adapted to inject coolant into at least one of the multiplicity of cooling passages upon the detection of the thermal runaway event by the any one of the multiplicity of sensors, so that the thermal runaway event is rapidly quenched.

  7. Li-ion battery thermal runaway suppression system using microchannel coolers and refrigerant injections

    Energy Technology Data Exchange (ETDEWEB)

    Bandhauer, Todd M.; Farmer, Joseph C.

    2016-11-08

    A battery management system with thermally integrated fire suppression includes a multiplicity of individual battery cells in a housing; a multiplicity of cooling passages in the housing within or between the multiplicity of individual battery cells; a multiplicity of sensors operably connected to the individual battery cells, the sensors adapted to detect a thermal runaway event related to one or more of the multiplicity of individual battery cells; and a management system adapted to inject coolant into at least one of the multiplicity of cooling passages upon the detection of the thermal runaway event by the any one of the multiplicity of sensors, so that the thermal runaway event is rapidly quenched.

  8. Hybrid wireless-over-fiber transmission system based on multiple injection-locked FP LDs.

    Science.gov (United States)

    Li, Chung-Yi; Lu, Hai-Han; Chu, Chien-An; Ying, Cheng-Ling; Lu, Ting-Chien; Peng, Peng-Chun

    2015-07-27

    A hybrid wireless-over-fiber (WoF) transmission system based on multiple injection-locked Fabry-Perot laser diodes (FP LDs) is proposed and experimentally demonstrated. Unlike the traditional hybrid WoF transmission systems that require multiple distributed feedback (DFB) LDs to support different kinds of services, the proposed system employs multiple injection-locked FP LDs to provide different kinds of applications. Such a hybrid WoF transmission system delivers downstream intensity-modulated 20-GHz microwave (MW)/60-GHz millimeter-wave (MMW)/550-MHz cable television (CATV) signals and upstream phase-remodulated 20-GHz MW signal. Excellent bit error rate (BER), carrier-to-noise ratio (CNR), composite second-order (CSO), and composite triple-beat (CTB) are observed over a 40-km single-mode fiber (SMF) and a 4-m radio frequency (RF) wireless transport. Such a hybrid WoF transmission system has practical applications for fiber-wireless convergence to provide broadband integrated services, including telecommunication, data communication, and CATV services.

  9. Application of flow-injection potentiometric system for determination of total concentration of aliphatic carboxylic acids.

    Science.gov (United States)

    Mroczkiewicz, Monika; Górski, Łukasz; Zamojska-Jaroszewicz, Anna; Szewczyk, Krzysztof W; Malinowska, Elżbieta

    2011-09-30

    In this work, flow-injection system with potentiometric detection was tested for determination of total carboxylic acid concentration. Detection part of the examined system consists of ion-selective electrodes (ISEs) with polymer membranes of different compositions. First electrode is based on Zr(IV)-tetraphenylporphyrin as ionophore selective towards carboxylic acid anions, the membrane of second one contains only liphophilic anion exchanger - tridodecylmethylammonium chloride. Final response of the system is a result of combination of EMF signals from both electrodes. Combination of two detectors enables significant decrease of differences between potentiometric signals induced by mixtures of studied anions of various concentrations as compared to results obtained only with metalloporphyrin-based ISE. The use of anion-exchanger based detector allows for elimination of the influence of aliphatic carboxylic acids lipophilicity. Proposed potentiometric flow-injection system was employed for determination of short-chain aliphatic carboxylic acids (so-called VFA - volatile fatty acids) in samples originating from an anaerobic digester. Results obtained for these relatively complicated samples are in good agreement with results obtained with the use of reference colorimetric method. Linear response towards carboxylic acids was observed in the concentration range of 10(-4) to 10(-2)mold m(-3), with the slopes in the range of -110 to -150 mV dec(-1) (for acetate(-) and butyrate(-), respectively). System enables for determination of about 6 samples per hour. Life time of ISEs average about 2 months.

  10. Model predictive control of servo motor driven constant pump hydraulic system in injection molding process based on neurodynamic optimization

    Institute of Scientific and Technical Information of China (English)

    Yong-gang PENG; Jun WANG; Wei WEI

    2014-01-01

    In view of the high energy consumption and low response speed of the traditional hydraulic system for an injection molding machine, a servo motor driven constant pump hydraulic system is designed for a precision injection molding process, which uses a servo motor, a constant pump, and a pressure sensor, instead of a common motor, a constant pump, a pressure pro-portion valve, and a flow proportion valve. A model predictive control strategy based on neurodynamic optimization is proposed to control this new hydraulic system in the injection molding process. Simulation results showed that this control method has good control precision and quick response.

  11. [Apply association rules to analysis adverse drug reactions of shuxuening injection based on spontaneous reporting system data].

    Science.gov (United States)

    Yang, Wei; Xie, Yan-Ming; Xiang, Yong-Yang

    2014-09-01

    This research based on the analysis of spontaneous reporting system (SRS) data which the 9 601 case reports of Shuxuening injection adverse drug reactions (ADR) in national adverse drug reaction monitoring center during 2005-2012. Apply to the association rules to analysis of the relationship between Shuxuening injection's ADR and the characteristics of ADR reports were. We found that ADR commonly combination were "nausea + breath + chills + vomiting", "nausea + chills + vomiting + palpitations", and their confidence level were 100%. The ADR and the case reports information commonly combination were "itching, and glucose and sodium chloride Injection, and generally ADR report, and normal dosage", "palpitation, and glucose and sodium chloride injection, and normal dosage, and new report", "chills, and generally ADR report, and normal dosage, and 0.9% sodium chloride injection", and their confidence level were 100% too. The results showed that patients using Shuxuening injection occurred most of ADRs were systemic damage, skin and its accessories damage, digestive system damage, etc. And most of cases were generally and new reports, and patients with normal dosage. The ADR's occurred had little related with solvent. It is showed that the Shuxuening injection occurred of ADR mainly related to drug composition. So Shuxuening injection used in clinical need to closely observation, and focus on the ADR reaction, and to do a good job of drug risk management.

  12. Performance Analysis of AP1000 Passive Systems during Direct Vessel Injection (DVI Line Break

    Directory of Open Access Journals (Sweden)

    A.S. Ekariansyah

    2016-08-01

    Full Text Available Generation II Nuclear Power Plants (NPPs have a design weakness as shown by the Fukushima accident. Therefore, Generation III+ NPPs are developed with focus on improvements of fuel technology and thermal efficiency, standardized design, and the use of passive safety system. One type of Generation III+ NPP is the AP1000 that is a pressurized water reactor (PWR type that has received the final design acceptance from US-NRC and is already under construction at several sites in China as of 2015. The aim of this study is to investigate the behavior and performance of the passive safety system in the AP1000 and to verify the safety margin during the direct vessel injection (DVI line break as selected event. This event was simulated using RELAP5/SCDAP/Mod3.4 as a best-estimate code developed for transient simulation of light water reactors during postulated accidents. This event is also described in the AP1000 design control document as one of several postulated accidents simulated using the NOTRUMP code. The results obtained from RELAP5 calculation was then compared with the results of simulations using the NOTRUMP code. The results show relatively good agreements in terms of time sequences and characteristics of some injected flow from the passive safety system. The simulation results show that the break of one of the two available DVI lines can be mitigated by the injected coolant flowing, which is operated effectively by gravity and density difference in the cooling system and does not lead to core uncovery. Despite the substantial effort to obtain an apropriate AP1000 model due to lack of detailed geometrical data, the present model can be used as a platform model for other initiating event considered in the AP1000 accident analysis.

  13. IMPACT OF DME-DIESEL FUEL BLEND PROPERTIES ON DIESEL FUEL INJECTION SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Elana M. Chapman; Andre Boehman; Kimberly Wain; Wallis Lloyd; Joseph M. Perez; Donald Stiver; Joseph Conway

    2003-06-01

    The objectives of this research program are to develop information on lubricity and viscosity improvers and their impact on the wear mechanisms in fuel injectors operating on blends of dimethyl ether (DME) and diesel fuel. Since DME is a fuel with no lubricity (i.e., it does not possess the lubricating quality of diesel fuel), conventional fuel delivery and fuel injection systems are not compatible with dimethyl ether. Therefore, to operate a diesel engine on DME one must develop a fuel-tolerant injection system, or find a way to provide the necessary lubricity to the DME. In the shuttle bus project, we have chosen the latter strategy in order to achieve the objective with minimal need to modify the engine. Our strategy is to blend DME with diesel fuel, to obtain the necessary lubricity to protect the fuel injection system and to achieve low emissions. In this project, we have sought to develop methods for extending the permissible DME content in the DME-diesel blends without experiencing rapid injector failure due to wear. To date, our activities have covered three areas: examination of the impact of lubricity additives on the viscosity of DME, development of a high-pressure lubricity test apparatus for studies of lubricity and viscosity improvers and development of an injector durability stand for evaluation of wear rates in fuel injectors. This report provides summaries of the progress toward evaluation of the viscosity impacts of lubricity additives, completion of both experimental systems and a summary of the plan for completion of the project objectives.

  14. Application of the BacT/ALERTR 3D system for sterility testing of injectable products

    Directory of Open Access Journals (Sweden)

    Adriana Bugno

    2015-09-01

    Full Text Available Sterility testing as described in the pharmacopoeia compendia requires a 14-day incubation period to obtain an analytical result. Alternative methods that could be applied to evaluating product sterility are especially interesting due to the possibility of reducing this incubation period and thus the associated costs. The aims of this study were to evaluate the performance of the BacT/ALERTR 3D system in detecting microorganisms in large-volume parenteral solutions that were intentionally contaminated and to compare this system to pharmacopoeia sterility testing using the membrane filtration method. The results indicated that there were no significant differences between the methods regarding the ability to detect microbial contamination; however, detection with the BacT/ALERTR 3D system was faster compared to the pharmacopoeia method. Therefore, the BacT/ALERTR 3D system is a viable alternative for assessing the sterility of injectable products.

  15. Improvement of replication fidelity in injection moulding of nano structures using an induction heating system

    DEFF Research Database (Denmark)

    Menotti, Stefano; Hansen, Hans Nørgaard; Bissacco, Giuliano

    2014-01-01

    In today’s industry, applications involving surface pattering with sub-μm scale structures have shown a high interest. The replication of these structures by injection molding leads to special requirements for the mold in order to ensure proper replication and an acceptable cycle time. A tool...... quantitatively characterized by atomic force microscopy comparing the measurement in the nickel insert with the corresponding polymer nano-features. The experimental results show that the use of the induction heating system is an efficient way to improve the pattern replication....

  16. Fault Diagnosis Of A Water For Injection System Using Enhanced Structural Isolation

    DEFF Research Database (Denmark)

    Laursen, Morten; Blanke, Mogens; Düstegör, Dilek

    2008-01-01

    A water for injection system supplies chilled sterile water as solvent to pharmaceutical products. There are ultimate requirements to the quality of the sterile water, and the consequence of a fault in temperature or in flow control within the process may cause loss of one or more batches...... of the production. Early diagnosis of faults is hence of considerable interest for this process. This study investigates the properties of multiple matchings with respect to isolability and it suggests to explore the topologies of multiple use-modes for the process and to employ active techniques for fault...

  17. Potentiometric electronic tongue-flow injection analysis system for the monitoring of heavy metal biosorption processes

    OpenAIRE

    2012-01-01

    An automated flow injection potentiometric (FIP) system with electronic tongue detection (ET) is used for the monitoring of biosorption processes of heavy metals on vegetable wastes. Grape stalk wastes are used as biosorbent to remove Cu2+ ions in a fixed-bed column configuration. The ET is formed by a 5-sensor array with Cu2+ and Ca2+-selective electrodes and electrodes with generic response to heavy-metals, plus an artificial neural network response model of the sensor's cross-response. The...

  18. LOCA air-injection loads in BWR Mark II pressure suppression containment systems

    Energy Technology Data Exchange (ETDEWEB)

    Kukita, Y.; Shiba, M. (Japan Atomic Energy Research Inst., Tokai, Ibaraki); Namatame, K. (Institute of Nuclear Safety, Tokyo (Japan))

    1984-02-01

    Large-scale blowdown tests were conducted to investigate the thermal-hydrodynamic response of a boiling-water reactor (BWR) Mark II pressure suppression containment system to a postulated loss-of-coolant accident. This paper presents the test results on the early blowdown transients, where air in the drywell is injected into the pressure suppression pool and induces various hydrodynamic loads onto the containment pressure boundary and internal structures. The test data are compared to predictions by analytical models used for the licensing evaluation of the hydrodynamic loads to assess these models.

  19. Improvement of replication fidelity in injection moulding of nano structures using an induction heating system

    DEFF Research Database (Denmark)

    Menotti, Stefano; Hansen, Hans Nørgaard; Bissacco, Giuliano

    2014-01-01

    In today’s industry, applications involving surface pattering with sub-μm scale structures have shown a high interest. The replication of these structures by injection molding leads to special requirements for the mold in order to ensure proper replication and an acceptable cycle time. A tool ins...... quantitatively characterized by atomic force microscopy comparing the measurement in the nickel insert with the corresponding polymer nano-features. The experimental results show that the use of the induction heating system is an efficient way to improve the pattern replication....

  20. Chemiluminescence Determination of Molybdenum by on-Line Reduction with a Flow Injection System

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The chemiluminescence (CL) reaction between lucigenin (Lu) and molybdenum (Ⅲ) produced by a Jones reductor was investigated using a flow injection system. On the basis of this, a novel method for the determination of trace amount of molybdenum has been established. The emission intensity was linear with molybdenum concentration in the range of 0.1-1000 ng/mL; the detection limit was 0.02 ng/mL molybdenum; the relative standard deviation was less than 2% for the determination of 0.1 ng/mL molybdenum (n=11). The method has been applied successfully to the analysis of trace molybdenum in water and steel samples.

  1. Linear Modeling, Simulation and Experimental Verification of a Pressure Regulator for CNG Injection Systems

    Directory of Open Access Journals (Sweden)

    Dirk Hübner

    2008-08-01

    Full Text Available The number of motor vehicles powered by internal combustion engines keeps growing despite shrinking oil reserves. As a result, compressed natural gas (CNG is gaining currency as an emerging combustion engine fuel. To this day, CNG systems – e.g., in passenger cars – are not fully integrated into the development process as conducted by vehicle or engine manufacturers. Instead, they are usually "adapted in" at a downstream stage by small, specialized companies. The present paper initially outlines the state of the art in advanced gas injection technologies. Especially the development towards sequential injection systems is described. A pressure regulator for CNG driven combustion engines is examined in detail, given its role as a highly sensitive and critical system component. Based on a precise theoretical analysis, a linear model of this pressure regulator is derived and subjected to dynamic simulation. The analytical approach is accompanied by an experimental investigation of the device. On a test rig developed at the Trier University of Applied Sciences, the static and dynamic features of the pressure regulator can be measured with the requisite precision. The comparison of measured and simulated data yields a validation of the dynamic simulation model. With the approaches developed it is now possible for the first time to model, simulate and optimize single- or multi-stage pressure regulators for CNG driven engines with less effort and higher accuracy.

  2. Detecting Solenoid Valve Deterioration in In-Use Electronic Diesel Fuel Injection Control Systems

    Directory of Open Access Journals (Sweden)

    Chyuan-Yow Tseng

    2010-07-01

    Full Text Available The diesel engine is the main power source for most agricultural vehicles. The control of diesel engine emissions is an important global issue. Fuel injection control systems directly affect fuel efficiency and emissions of diesel engines. Deterioration faults, such as rack deformation, solenoid valve failure, and rack-travel sensor malfunction, are possibly in the fuel injection module of electronic diesel control (EDC systems. Among these faults, solenoid valve failure is most likely to occur for in-use diesel engines. According to the previous studies, this failure is a result of the wear of the plunger and sleeve, based on a long period of usage, lubricant degradation, or engine overheating. Due to the difficulty in identifying solenoid valve deterioration, this study focuses on developing a sensor identification algorithm that can clearly classify the usability of the solenoid valve, without disassembling the fuel pump of an EDC system for in-use agricultural vehicles. A diagnostic algorithm is proposed, including a feedback controller, a parameter identifier, a linear variable differential transformer (LVDT sensor, and a neural network classifier. Experimental results show that the proposed algorithm can accurately identify the usability of solenoid valves.

  3. Detecting solenoid valve deterioration in in-use electronic diesel fuel injection control systems.

    Science.gov (United States)

    Tsai, Hsun-Heng; Tseng, Chyuan-Yow

    2010-01-01

    The diesel engine is the main power source for most agricultural vehicles. The control of diesel engine emissions is an important global issue. Fuel injection control systems directly affect fuel efficiency and emissions of diesel engines. Deterioration faults, such as rack deformation, solenoid valve failure, and rack-travel sensor malfunction, are possibly in the fuel injection module of electronic diesel control (EDC) systems. Among these faults, solenoid valve failure is most likely to occur for in-use diesel engines. According to the previous studies, this failure is a result of the wear of the plunger and sleeve, based on a long period of usage, lubricant degradation, or engine overheating. Due to the difficulty in identifying solenoid valve deterioration, this study focuses on developing a sensor identification algorithm that can clearly classify the usability of the solenoid valve, without disassembling the fuel pump of an EDC system for in-use agricultural vehicles. A diagnostic algorithm is proposed, including a feedback controller, a parameter identifier, a linear variable differential transformer (LVDT) sensor, and a neural network classifier. Experimental results show that the proposed algorithm can accurately identify the usability of solenoid valves.

  4. Feasibility Study of the PS Injection for 2 GeV LIU Beams with an Upgraded KFA-45 Injection Kicker System Operating in Short Circuit Mode

    CERN Document Server

    Kramer, Thomas; Borburgh, Jan; Ducimetière, Laurent; Feliciano, Luis; Ferrero Colomo, Alvaro; Goddard, Brennan; Sermeus, Luc

    2016-01-01

    Under the scope of the LIU project the CERN PS Booster to PS beam transfer will be modified to match the requirements for the future 2 GeV beams. This paper describes the evaluation of the proposed upgrade of the PS injection kicker. Different schemes of an injection for LIU beams into the PS have been outlined in the past already under the aspect of individual transfer kicker rise and fall time performances. Homogeneous rise and fall time requirements in the whole PSB to PS transfer chain have been established which allowed to consider an upgrade option of the present injection kicker system operated in short circuit mode. The challenging pulse quality constraints require an improvement of the flat top and post pulse ripples. Both operation modes, terminated and short circuit mode are analysed and analogue circuit simulations for the present and upgraded system are outlined. Recent measurements on the installed kickers are presented and analysed together with the simulation data. First measurements verifying...

  5. Long-term pulmonary and systemic toxicity following intravenous mercury injection

    Energy Technology Data Exchange (ETDEWEB)

    Dell`Omo, M.; Muzi, G.; Filiberto, S.; Abbritti, G. [Institute of Occupational Medicine, Department of Clinical Medicine, Pathology and Pharmacology, University of Perugia, Via E. dal Pozzo, 06100 Perugia (Italy); Bernard, A.; Lauwerys, R.R. [Unite de Toxicologie Industrielle et Medicine du Travail, Universite Catholique de Louvain, Clos Chapelle-aux Champs 30 - BTE 30.54, 1200 Bruxelles (Belgium)

    1997-12-01

    Long-term pulmonary and systemic toxicity following mercury intravenous injection has rarely been assessed. We present the results of a detailed investigation assessing pulmonary and systemic long-term toxic effects in a subject who had pulmonary and systemic mercury microembolism diagnosed more than 11 years previously. Radiographic examination showed the persistence of mercury microemboli in both lungs and elsewhere in the body. Lung function tests revealed a decreased diffusing capacity for carbon monoxide and Po{sub 2} probably indicative of microscopic inflammation of lung interstitium. Electroneuromyography showed signs of mild axonopathy in both legs. At semen analysis, a high proportion of motionless spermatozoa was present. Urinary excretion of mercury was high. Signs of interstitial lung impairment, peripheral axonopathy and asthenozoospermia in a subject who had mercury microembolism persisting for more than 11 years might be evidence of long-term mercury toxicity. (orig.) With 2 figs., 33 refs.

  6. Development of water soluble binder systems for low pressure injection molding of alumina

    Energy Technology Data Exchange (ETDEWEB)

    Bakan, H.I.; Gunes, M. [TUBITAK-MRC Materials and Chemical Technologies Research Inst., Kocaeli (Turkey)

    2004-07-01

    Low pressure injection molding of alumina powder using a water-soluble binder system has been carried out successfully. The water-soluble based binder system consisted of poly (2-ethyl-2-oxaline), low density polyethylene and stearic acid. The critical powder loading of the binder-powder mixture was determined based on torque rheometry experiments. The rheological properties of the powder-binder mixture were investigated systematically. The binder system used provides satisfactory mixture stability, excellent mouldability and reasonably fast water leaching and thermal debinding rates. The water-soluble constituent, poly (2-ethyl-2-oxaline), was removed by leaching in convecting water at 60 C within 6 hour. The remaining binder constituents were thermally removed during heating to 450 C. Sintering of the parts was conducted at 1550 C for an hour in air. (orig.)

  7. Yersinia enterocolitica targets cells of the innate and adaptive immune system by injection of Yops in a mouse infection model.

    Directory of Open Access Journals (Sweden)

    Martin Köberle

    2009-08-01

    Full Text Available Yersinia enterocolitica (Ye evades the immune system of the host by injection of Yersinia outer proteins (Yops via a type three secretion system into host cells. In this study, a reporter system comprising a YopE-beta-lactamase hybrid protein and a fluorescent staining sensitive to beta-lactamase cleavage was used to track Yop injection in cell culture and in an experimental Ye mouse infection model. Experiments with GD25, GD25-beta1A, and HeLa cells demonstrated that beta1-integrins and RhoGTPases play a role for Yop injection. As demonstrated by infection of splenocyte suspensions in vitro, injection of Yops appears to occur randomly into all types of leukocytes. In contrast, upon infection of mice, Yop injection was detected in 13% of F4/80(+, 11% of CD11c(+, 7% of CD49b(+, 5% of Gr1(+ cells, 2.3% of CD19(+, and 2.6% of CD3(+ cells. Taking the different abundance of these cell types in the spleen into account, the highest total number of Yop-injected cells represents B cells, particularly CD19(+CD21(+CD23(+ follicular B cells, followed by neutrophils, dendritic cells, and macrophages, suggesting a distinct cellular tropism of Ye. Yop-injected B cells displayed a significantly increased expression of CD69 compared to non-Yop-injected B cells, indicating activation of these cells by Ye. Infection of IFN-gammaR (receptor- and TNFRp55-deficient mice resulted in increased numbers of Yop-injected spleen cells for yet unknown reasons. The YopE-beta-lactamase hybrid protein reporter system provides new insights into the modulation of host cell and immune responses by Ye Yops.

  8. Usability of a real-time tracked augmented reality display system in musculoskeletal injections

    Science.gov (United States)

    Baum, Zachary; Ungi, Tamas; Lasso, Andras; Fichtinger, Gabor

    2017-03-01

    PURPOSE: Image-guided needle interventions are seldom performed with augmented reality guidance in clinical practice due to many workspace and usability restrictions. We propose a real-time optically tracked image overlay system to make image-guided musculoskeletal injections more efficient and assess its usability in a bed-side clinical environment. METHODS: An image overlay system consisting of an optically tracked viewbox, tablet computer, and semitransparent mirror allows users to navigate scanned patient volumetric images in real-time using software built on the open-source 3D Slicer application platform. A series of experiments were conducted to evaluate the latency and screen refresh rate of the system using different image resolutions. To assess the usability of the system and software, five medical professionals were asked to navigate patient images while using the overlay and completed a questionnaire to assess the system. RESULTS: In assessing the latency of the system with scanned images of varying size, screen refresh rates were approximately 5 FPS. The study showed that participants found using the image overlay system easy, and found the table-mounted system was significantly more usable and effective than the handheld system. CONCLUSION: It was determined that the system performs comparably with scanned images of varying size when assessing the latency of the system. During our usability study, participants preferred the table-mounted system over the handheld. The participants also felt that the system itself was simple to use and understand. With these results, the image overlay system shows promise for use in a clinical environment.

  9. Distribution of /sup 109/Cd in the nervous system of rats after intravenous injection

    Energy Technology Data Exchange (ETDEWEB)

    Arvidson, B.; Tjaelve, H.

    1985-11-01

    The distribution of intravenously injected /sup 109/Cd in the nervous system was studied in rats twenty-four hr and one week after the injection. Measurements by gamma scintillation showed a high uptake of cadmium in peripheral sensory and autonomic ganglia whereas the uptake was low in the brain, cerebellum and spinal cord. The accumulation of cadmium in the sciatic nerve was significantly higher than in the brain and spinal nerve roots but lower than in ganglia. Autoradiography confirmed that there was no uptake of cadmium in the major part of the brain parenchyma, but showed an accumulation of the metal in areas outside the blood-brain barrier such as the hypophysis, meninges, choroid plexus and pineal gland. Within the peripheral nervous system, the autoradiography showed a localization of cadmium to dorsal root ganglia and, in addition, an uptake was seen in the connective tissue sheaths surrounding the sciatic nerve. The results indicate that the uptake of cadmium is correlated to regional variations in the permeability of blood vessels. The accumulation of cadmium in certain nervous structures may explain some of the neurotoxicological effects which have been demonstrated in animal experiments.

  10. Photoelectrocatalytic determination of NADH in a flow injection system with electropolymerized methylene blue

    Energy Technology Data Exchange (ETDEWEB)

    Dilgin, Yusuf, E-mail: ydilgin@yahoo.co [Canakkale Onsekiz Mart University, Science and Art Faculty, Department of Chemistry, TR-17100 Canakkale (Turkey); Dilgin, Didem Giray [Canakkale Onsekiz Mart University, Biga Vocational College, TR-17200 Biga Canakkale (Turkey); Ege University, Science Faculty, Department of Chemistry, TR-35100 Bornova/Izmir (Turkey); Dursun, Zekerya; Goekcel, H. Ismet [Ege University, Science Faculty, Department of Chemistry, TR-35100 Bornova/Izmir (Turkey); Gligor, Delia [Department of Environmental Physics, Chemistry and Engineering, ' Babes-Bolyai' University, 30 Fantanele St., 400294 Cluj-Napoca (Romania); Bayrak, Burcu; Ertek, Bensu [Canakkale Onsekiz Mart University, Science and Art Faculty, Department of Chemistry, TR-17100 Canakkale (Turkey)

    2011-01-01

    It was firstly described that a glassy carbon electrode electropolymerized with methylene blue shows an efficient photoelectrocatalytic activity towards NADH oxidation in a phosphate buffer solution (pH 7.0). In order to perform the photoelectrocatalytic determination of NADH in a flow injection analysis (FIA) system, a home-made flow electrochemical cell with a suitable transparent window for the irradiation of the electrode surface was constructed. The currents obtained from the photoamperometric measurements in the FIA system at optimum conditions (flow rate of carrier solution, 1.3 mL min{sup -1}; transmission tubing length, 10 cm; injection volume, 100 {mu}L; and constant applied potential, +150 mV vs. Ag/AgCl) were linearly dependent on the NADH concentration and linear calibration curves were obtained in the range of 1.0 x 10{sup -7}-2.0 x 10{sup -4} M. The detection limit was found to be 4.0 x 10{sup -8} M for photoamperometric determination of NADH.

  11. A supersonic gas injection system for fuelling and probing fusion plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Collis, Scott [Research School of Physical Sciences and Engineering, Australian National University, Canberra, ACT 0200 (Australia); Howard, John [Research School of Physical Sciences and Engineering, Australian National University, Canberra, ACT 0200 (Australia); Blackwell, Boyd [Research School of Physical Sciences and Engineering, Australian National University, Canberra, ACT 0200 (Australia); Carlsson, Peter [Department of Physics and Engineering Physics, Chalmers University of Technology, SE-412 96 Goeteburg (Sweden); Abelsson, Mattias [Department of Physics and Engineering Physics, Chalmers University of Technology, SE-412 96 Goeteburg (Sweden); Powell, Ben [Research School of Physical Sciences and Engineering, Australian National University, Canberra, ACT 0200 (Australia)

    2006-11-01

    The large gas reservoir surrounding the H-1NF plasma leads to difficulties in achieving the density control required to maximize the plasma temperature. We have designed and tested an alternative fuelling system which uses a double conical nozzle to generate a directed flow of particles into the plasma without adding to the gas inventory in the rest of the vacuum vessel. By using a closed plenum at a programmable pressure and a piezo-electric valve, the particle flux can be dynamically changed in a controlled and quantitative manner. Measurements of the gas jet using constant temperature hot wire anemometry show that, for plenum pressures between 500 and 1000 Torr, the particle injection rate (helium) ranges between 2 x 10{sup 20} and 4 x 10{sup 20} s{sup -1} with half-cone angles between 5 deg. and 20 deg. The system has been installed on the H-1NF device and first plasma results indicate localized gas injection consistent with test tank anemometry measurements.

  12. Low-power wide-locking-range injection-locked frequency divider for OFDM UWB systems

    Energy Technology Data Exchange (ETDEWEB)

    Yin Jiangwei; Li Ning; Zheng Renliang; Li Wei; Ren Junyan, E-mail: lining@fudan.edu.c [State Key Laboratory of ASIC and System, Fudan University, Shanghai 201203 (China)

    2009-05-01

    This paper describes a divide-by-two injection-locked frequency divider (ILFD) for frequency synthesizers as used in multiband orthogonal frequency division multiplexing (OFDM) ultra-wideband (UWB) systems. By means of dual-injection technique and other conventional tuning techniques, such as DCCA and varactor tuning, the divider demonstrates a wide locking range while consuming much less power. The chip was fabricated in the Jazz 0.18 mum RF CMOS process. The measurement results show that the divider achieves a locking range of 4.85 GHz (6.23 to 11.08 GHz) at an input power of 8 dBm. The core circuit without the test buffer consumes only 3.7 mA from a 1.8 V power supply and has a die area of 0.38 x 0.28 mm{sup 2}. The wide locking range combined with low power consumption makes the ILFD suitable for its application in UWB systems.

  13. Study and Effects of UPFC and its Control System for Power Flow Control and Voltage Injection in a Power System

    Directory of Open Access Journals (Sweden)

    Vibhor Gupta

    2010-07-01

    Full Text Available The maintenance and reliability of the power system has become a major aspect of study. The encouragement to the construction of HV lines, the amount of power transmission/km on HV line and the amount of power transaction as seen from economic side is much responsible for concern towards congestion in power system. The solution is the use of FACTS devices especially the use of UPFC. In this paper the study of UPFC with its various modes of operation is understood. Second, the operation of control system used in its converters is also studied. Finally by help of modeling of a power system in ATLAB, and by installing UPFC in transmission link, its use as power flow controller and voltage injection is seen. Conclusion is made ondifferent results to see the benefit of UPFC in power system.

  14. PHYSICS RESULTS OF THE NSLS-II LINAC FRONT END TEST STAND

    Energy Technology Data Exchange (ETDEWEB)

    Fliller R. P.; Gao, F.; Yang, X.; Rose, J.; Shaftan, T.; Piel, C

    2012-05-20

    The Linac Front End Test Stand (LFETS) was installed at the Source Development Laboratory (SDL) in the fall of 2011 in order to test the Linac Front End. The goal of these tests was to test the electron source against the specifications of the linac. In this report, we discuss the results of these measurements and the effect on linac performance.

  15. Cardio-respiratory effects of systemic neurotensin injection are mediated through activation of neurotensin NTS₁ receptors.

    Science.gov (United States)

    Kaczyńska, Katarzyna; Szereda-Przestaszewska, Małgorzata

    2012-09-15

    The purpose of our study was to determine the cardio-respiratory pattern exerted by the systemic injection of neurotensin, contribution of neurotensin NTS(1) receptors and the neural pathways mediating the responses. The effects of an intravenous injection (i.v.) of neurotensin were investigated in anaesthetized, spontaneously breathing rats in following experimental schemes: (i) control animals before and after midcervical vagotomy; (ii) in three separate subgroups of rats: neurally intact, vagotomized at supranodosal level and initially midcervically vagotomized exposed to section of the carotid sinus nerves (CSNs); (iii) in the intact rats 2 minutes after blockade of neurotensin NTS(1) receptors with SR 142948. Intravenous injection of 10 μg/kg of neurotensin in the intact rats evoked prompt increase in the respiratory rate followed by a prolonged slowing down coupled with augmented tidal volume. Midcervical vagotomy precluded the effects of neurotensin on the frequency of breathing, while CSNs section reduced the increase in tidal volume. In all the neural states neurotensin caused significant fall in mean arterial blood pressure preceded by prompt hypertensive response. The cardio-respiratory effects of neurotensin were blocked by pre-treatment with NTS(1) receptor antagonist. The results of this study showed that neurotensin acting through NTS(1) receptors augments the tidal component of the breathing pattern in a large portion via carotid body afferentation whereas the respiratory timing response to neurotensin depends entirely on the intact midcervical vagi. Blood pressure effects evoked by an intravenous neurotensin occur outside vagal and CSNs pathways and might result from activation of the peripheral vascular NTS(1) receptors.

  16. Fuel injection and mixing systems and methods of using the same

    Science.gov (United States)

    Mao, Chien-Pei; Short, John

    2010-08-03

    A fuel injection and mixing system is provided. The system includes an injector body having a fuel inlet and a fuel outlet, and defines a fuel flow path between the inlet and outlet. The fuel flow path may include a generally helical flow passage having an inlet end portion disposed proximate the fuel inlet of the injector body. The flow path also may include an expansion chamber downstream from and in fluid communication with the helical flow passage, as well as a fuel delivery device in fluid communication with the expansion chamber for delivering fuel. Heating means is also provided in thermal communication with the injector body. The heating means may be adapted and configured for maintaining the injector body at a predetermined temperature to heat fuel traversing the flow path. A method of preheating and delivering fuel is also provided.

  17. Rapid antioxidant capacity screening in herbal extracts using a simple flow injection-spectrophotometric system.

    Science.gov (United States)

    Mrazek, Nookrai; Watla-iad, Kanchana; Deachathai, Suwanna; Suteerapataranon, Siripat

    2012-05-01

    A simple flow injection (FI)-spectrophotometric system for the screening of antioxidant capacity in herbal extracts was developed. The analysis was based on the color disappearance due to the scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical by antioxidant compounds. DPPH and ascorbic acid were used as reagent and antioxidant standard, respectively. Effects of the DPPH concentration, DPPH flow rate, and reaction coil length on sensitivity were studied. The optimized condition provided the linear range of 0.010-0.300mM ascorbic acid with less than 5%RSD(n=10). Detection limit and quantitation limit were 0.004 and 0.013mM, respectively. Comparison of antioxidant capacity in some herbal extracts determined by the FI system and a standard method was carried out and no significant difference was obtained.

  18. Voltage inverter with push-pull topology to inject energy into electrical systems with modulation SPWM

    Directory of Open Access Journals (Sweden)

    Emerson Charles M. Silva

    2013-09-01

    Full Text Available This paper presents a proposal for a voltage inverter topology based on push-pull converters, switched at high frequency to inject energy into the grid from a source of DC power. A system using two reverse voltage static converters provides the power grid; energy in the form of alternating current, that can work in conjunction with the provision of utility power. Aiming at the possible use of renewable energy sources, that can be stored in the form of voltage continuous, such as wind, solar, hydroelectric and others. The functioning of topology is presented, such as the power and control circuits, as well as sizing components, theoretical and practical results achieved with the assembly of a prototype 100W of power and switching in 40khz, which after filtering provides the frequency of 60Hz, which is compatible with the Brazilian electrical system.

  19. Novel in vivo imaging analysis of an inner ear drug delivery system in mice: comparison of inner ear drug concentrations over time after transtympanic and systemic injections.

    Directory of Open Access Journals (Sweden)

    Sho Kanzaki

    Full Text Available OBJECTIVE: Systemic steroid injections are used to treat idiopathic sudden-onset sensorineural hearing loss (ISSHL and some inner ear disorders. Recent studies show that transtympanic (TT steroid injections are effective for treating ISSHL. As in vivo monitoring of drug delivery dynamics for inner ear is lacking, its time course and dispersion of drugs is unknown. Here, we used a new in vivo imaging system to monitor drug delivery in live mice and to compare drug concentrations over time after TT and systemic injections. METHODS: Luciferin delivered into the inner ears of GFAP-Luc transgenic mice reacted with luciferase in GFAP-expressing cells in the cochlear spiral ganglion, resulting in photon bioluminescence. We used the Xenogen IVIS® imaging system to measure how long photons continued to be emitted in the inner ear after TT or systemic injections of luciferin, and then compared the associated drug dynamics. RESULTS: The response to TT and IP injections differed significantly. Photons were detected five minutes after TT injection, peaking at ~20 minutes. By contrast, photons were first detected 30 minutes after i.p. injection. TT and i.p. drug delivery time differed considerably. With TT injections, photons were detected earlier than with IP injections. Photon bioluminescence also disappeared sooner. Delivery time varied with TT injections. CONCLUSIONS: We speculate that the drug might enter the Eustachian tube from the middle ear. We conclude that inner-ear drug concentration can be maintained longer if the two injection routes are combined. As the size of luciferin differs from that of therapeutics like dexamethasone, combining drugs with luciferin may advance our understanding of in vivo drug delivery dynamics in the inner ear.

  20. Thermogelling chitosan–collagen–bioactive glass nanoparticle hybrids as potential injectable systems for tissue engineering

    Energy Technology Data Exchange (ETDEWEB)

    Moreira, Cheisy D.F.; Carvalho, Sandhra M.; Mansur, Herman S., E-mail: hmansur@demet.ufmg.br; Pereira, Marivalda M., E-mail: mpereira@demet.ufmg.br

    2016-01-01

    Recently, stimuli-responsive nanocomposite-derived hydrogels have gained prominence in tissue engineering because they can be applied as injectable scaffolds in bone and cartilage repair. Due to the great potential of these systems, this study aimed to synthesize and characterize novel thermosensitive chitosan-based composites, chemically modified with collagen and reinforced by bioactive glass nanoparticles (BG) on the development of injectable nanohybrids for regenerative medicine applications. Thus, the composite hydrogels were extensively characterized by structural, morphological, rheological, and biological testing. The composites showed thermosensitive response with the gelation temperature at approximately 37 °C, which is compatible with the human body temperature. In addition, scanning electron microscopy (SEM) analysis indicated that the chitosan hydrogels exhibited 3D-porous structures, and the incorporation of collagen in the system caused increase on the average pore size. Fourier transform infrared spectroscopy (FTIR) analysis indicated the main functional groups of each component of the composite system and their chemical interactions forming the scaffold. Moreover, rheological measurements were employed to assess the viscoelastic behavior of the hydrogels as a function of the temperature. The results demonstrated that the addition of collagen and bioactive glass increases the mechanical properties after the gelation process. The addition of 2 wt.% of BG nanoparticles caused an increase of approximately 39% on stiffness compared to pure chitosan and the addition of 30 wt.% collagen caused a further increase on the stiffness by 95%. The cytotoxicity and cell viability of the hydrogels were assessed by MTT and LIVE/DEAD® assays, where the results demonstrated no toxic effect of the composites on the human osteosarcoma cell culture (SAOS) and kidney cells line of human embryo (HEK 293T). Hence, it can be stated that innovative composites were

  1. Design of a microscopic electrical impedance tomography system using two current injections.

    Science.gov (United States)

    Liu, Qin; Oh, Tong In; Wi, Hun; Lee, Eun Jung; Seo, Jin Keun; Woo, Eung Je

    2011-09-01

    We describe a novel design of a microscopic electrical impedance tomography (micro-EIT) system for long-term noninvasive monitoring of cell or tissue cultures. The core of the micro-EIT system is a sample container including two pairs of current-injection electrodes and 360 voltage-sensing electrodes. In designing the container, we took advantage of a hexagonal structure with fixed dimensions and electrode configuration. This eliminated technical difficulties related to the unknown irregular boundary geometry of an imaging object in conventional medical EIT. Attaching a pair of large current-injection electrodes fully covering the left and right sides of the hexagonal container, we generated uniform parallel current density inside the container filled with saline. The 360 voltage-sensing electrodes were placed on the front, bottom and back sides of the hexagonal container in three sets of 8 × 15 arrays with equal gaps between them. We measured voltage differences between all neighboring pairs along the direction of the parallel current pathway. For the homogeneous container, all measured voltages must be the same since the voltage changes linearly along that direction. Any anomaly in the container perturbed the current pathways and therefore equipotential lines to produce different differential voltage data. For conductivity image reconstructions, we adopted a lately developed image reconstruction algorithm for this electrode configuration to first produce projected conductivity images on the front, bottom and back sides. Using a backprojection method, we reconstructed three-dimensional conductivity images from those projection images. To improve the image quality and also to meet the mathematical requirement on the uniqueness of a reconstructed image, we used a second pair of thin and long current-injection electrodes located at the middle of the front and back sides. This paper describes the design and construction of such a micro-EIT system with experimental

  2. Rheological and thermal performance of newly developed binder systems for ceramic injection molding

    Science.gov (United States)

    Hausnerova, Berenika; Kasparkova, Vera; Hnatkova, Eva

    2016-05-01

    In a novel binder system, carnauba wax was considered to replace the synthetic backbone polymers (polyolefins) enhancing the environmental sustainability of Ceramic Injection Molding (CIM) technology. The paper presents comparison of the rheological performance and thermal behavior of the aluminum oxide CIM feedstocks based on a binder containing carnauba wax with those consisting of a commercial binder. Further, acrawax (N, N'-Ethylene Bis-stearamide) has been considered as another possible substitute of polyolefins. For both proposed substitutes there is a significant reduction in viscosity, and in case of carnauba wax based feedstock also in processing temperature, which is essential for injection molding of reactive powders. Thermal characterization comprised analyses of single neat binders, their mixtures and mixtures with aluminum oxide. The presence of powder lowered melting temperatures of all tested binders except of polyolefin. Further depression in melting point of poly(ethylene glycol) is observed in combination with polyolefin in the presence of powder, and it is related to changes in size of the crystalline domains.

  3. Rabbit IgG distribution in skin, spinal cord and DRG following systemic injection in rat.

    Science.gov (United States)

    Tonra, J R; Mendell, L M

    1997-12-01

    In order to determine the distribution of antibodies such as anti-NGF following systemic injection in neonates, immunocytochemical techniques were used to examine the localization of rabbit IgG in rat skin, DRG, and spinal cord after treatments with normal rabbit serum or purified rabbit IgG. Daily subcutaneous injections beginning on postnatal day 2 or on day 15 were given for three days. On the fourth day the animals were sacrificed and tissues were processed for rabbit IgG-IR. In the dorsal and ventral spinal cord, staining intensities suggest a substantial increase in the blood-brain barrier during the first two weeks after birth. Staining intensity in the epidermis of the glabrous skin from the hindpaw was substantially lower than in the adjacent dermis. In addition, IgG infrequently accumulated intracellularly in intensely stained patches in the epidermis. IgG was also able to reach relatively high intracellular concentrations in a small number of sensory neurons. The IgG staining pattern in the skin was similar when anti-NGF itself was administered to the animals. The results are discussed in the context of the effects of anti-NGF on the development of nociceptive afferents.

  4. Thermogelling chitosan-collagen-bioactive glass nanoparticle hybrids as potential injectable systems for tissue engineering.

    Science.gov (United States)

    Moreira, Cheisy D F; Carvalho, Sandhra M; Mansur, Herman S; Pereira, Marivalda M

    2016-01-01

    Recently, stimuli-responsive nanocomposite-derived hydrogels have gained prominence in tissue engineering because they can be applied as injectable scaffolds in bone and cartilage repair. Due to the great potential of these systems, this study aimed to synthesize and characterize novel thermosensitive chitosan-based composites, chemically modified with collagen and reinforced by bioactive glass nanoparticles (BG) on the development of injectable nanohybrids for regenerative medicine applications. Thus, the composite hydrogels were extensively characterized by structural, morphological, rheological, and biological testing. The composites showed thermosensitive response with the gelation temperature at approximately 37 °C, which is compatible with the human body temperature. In addition, scanning electron microscopy (SEM) analysis indicated that the chitosan hydrogels exhibited 3D-porous structures, and the incorporation of collagen in the system caused increase on the average pore size. Fourier transform infrared spectroscopy (FTIR) analysis indicated the main functional groups of each component of the composite system and their chemical interactions forming the scaffold. Moreover, rheological measurements were employed to assess the viscoelastic behavior of the hydrogels as a function of the temperature. The results demonstrated that the addition of collagen and bioactive glass increases the mechanical properties after the gelation process. The addition of 2 wt.% of BG nanoparticles caused an increase of approximately 39% on stiffness compared to pure chitosan and the addition of 30 wt.% collagen caused a further increase on the stiffness by 95%. The cytotoxicity and cell viability of the hydrogels were assessed by MTT and LIVE/DEAD® assays, where the results demonstrated no toxic effect of the composites on the human osteosarcoma cell culture (SAOS) and kidney cells line of human embryo (HEK 293 T). Hence, it can be stated that innovative composites were

  5. IMPACT OF DME-DIESEL FUEL BLEND PROPERTIES ON DIESEL FUEL INJECTION SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Elana M. Chapman; Andre Boehman; Kimberly Wain; Wallis Lloyd; Joseph M. Perez; Donald Stiver; Joseph Conway

    2004-04-01

    The objectives of this research program are to develop information on lubricity and viscosity improvers and their impact on the wear mechanisms in fuel injectors operating on blends of dimethyl ether (DME) and diesel fuel. Since DME is a fuel with no lubricity (i.e., it does not possess the lubricating quality of diesel fuel), conventional fuel delivery and fuel injection systems are not compatible with dimethyl ether. Therefore, to operate a diesel engine on DME one must develop a fuel-tolerant injection system, or find a way to provide the necessary lubricity to the DME. In the shuttle bus project, we have chosen the latter strategy in order to achieve the objective with minimal need to modify the engine. Our strategy is to blend DME with diesel fuel, to obtain the necessary lubricity to protect the fuel injection system and to achieve low emissions. In this project, we have sought to develop methods for extending the permissible DME content in the DME-diesel blends without experiencing rapid injector failure due to wear. Our activities have covered three areas: examination of the impact of lubricity additives on the viscosity of DME, development of a high-pressure lubricity test apparatus for studies of lubricity and viscosity improvers and development of an injector durability stand for evaluation of wear rates in fuel injectors. The first two of these areas have resulted in valuable information about the limitations of lubricity and viscosity additives that are presently available in terms of their impact on the viscosity of DME and on wear rates on injector hardware. The third area, that of development of an injector durability test stand, has not resulted in a functioning experiment. Some information is provided in this report to identify the remaining tasks that need to be performed to make the injector stand operational. The key observations from the work are that when blended at 25 wt.% in either diesel fuel or Biodiesel fuel, DME requires more than 5 wt

  6. Development of laser beam injection system for the Edge Thomson Scattering (ETS) in ITER

    Science.gov (United States)

    Yatsuka, E.; Hatae, T.; Suitoh, S.; Ohara, M.; Hagita, K.; Inoue, K.; Bassan, M.; Walsh, M.; Itami, K.

    2016-01-01

    This paper focuses on the design and development of the laser injection system for the ITER Edge Thomson Scattering system (ETS). The ITER ETS achieves a temporal resolution of 100 Hz by firing two 50 Hz laser beams alternatively. The use of dual lasers enables us to perform the Thomson scattering measurements at a temporal resolution of 50 Hz in case that one of the laser systems stops functioning. A new type of beam combiner was developed to obtain a single beam that is collinear and fixed linearly polarized from two laser beams using a motor-driven rotating half-wave plate. The rotating half-wave plate method does not induce misalignment even if the rotating mechanism malfunctions. The combined beam is relayed from the diagnostic hall to the plasma using mirror optics and is absorbed at the beam dump integrated on the inner blanket. The beam alignment system was designed to direct the laser beam onto the center of the beam dump head. The beam position at the beam dump is monitored by four alignment laser beams which propagate parallel to the diagnostic Nd:YAG laser beam and imaging systems installed outside the diagnostic port.

  7. Robust computer-controlled system for intracytoplasmic sperm injection and subsequent cell electro-activation.

    Science.gov (United States)

    Tan, K K; Huang, S; Tang, K Z

    2009-03-01

    Intracytoplasmic sperm injection (ICSI) and the subsequent cell electro-activation process is a relatively new enhanced procedure to address male factor infertility. The current method involves the engagement of experienced embryologists for such a purpose. More advanced methodologies, which use high precision instrumentation tools, will speed up the whole procedure. In this paper, the development of a computer-controlled system for ICSI and the subsequent cell electro-activation process is presented. The system is integrated to a microinjection workstation and piezo-actuator to perform the ICSI procedure, with vision capability to automatically position the components precisely. A micro-pump assembly is utilized for automatic medium refreshment and a heater plate assembly provides temperature control during the cell electro-activation process. The overall system is comprehensive, comprising modular functional components integrated within a hardware architecture. Experimental results on mice oocytes verified the effectiveness of the developed system over the current method. Further improvements on the instrumentation tools will improve the robustness and overall performance of the developed system.

  8. A New Four-Barrel Pellet Injection System for the TJ-II Stellarator

    Energy Technology Data Exchange (ETDEWEB)

    Combs, Stephen Kirk [ORNL; Foust, Charles R [ORNL; McGill, James M [ORNL; Baylor, Larry R [ORNL; Caughman, John B [ORNL; Fehling, Dan T [ORNL; Harris, Jeffrey H [ORNL; Meitner, Steven J [ORNL; Rasmussen, David A [ORNL; McCarthy, K. J. [EURATOM-CIEMAT, Madrid, Spain; Chamorro, M. [Laboratory Nacional de Fusion, Madrid, Spain; Garcia, R. [Laboratory Nacional de Fusion, Madrid, Spain; Hildago, C. [Laboratory Nacional de Fusion, Madrid, Spain; Medrano, M. [Laboratory Nacional de Fusion, Madrid, Spain; Unamuno, R. [Laboratory Nacional de Fusion, Madrid, Spain

    2011-01-01

    A new pellet injection system for the TJ-II stellarator has been developed/constructed as part of a collaboration between the Oak Ridge National Laboratory (ORNL) and the Centro de Investigaciones Energ ticas, Medioambientales y Tecnol gicas (CIEMAT). ORNL is providing most of the injector hardware and instrumentation, the pellet diagnostics, and the pellet transport tubes; CIEMAT is responsible for the injector stand/interface to the stellarator, cryogenic refrigerator, vacuum pumps/ballast volumes, gas manifolds, remote operations, plasma diagnostics, and data acquisition. The pellet injector design is an upgraded version of that used for the ORNL injector installed on the Madison Symmetric Torus (MST). It is a four-barrel system equipped with a cryogenic refrigerator for in situ hydrogen pellet formation and a combined mechanical punch/propellant valve system for pellet acceleration (speeds ~100 to 1000 m/s). On TJ-II, it will be used as an active diagnostic and for fueling. To accommodate the plasma experiments planned for TJ-II, pellet sizes significantly smaller than those typically used for the MST application are required. The system will initially be equipped with four different pellet sizes, with the gun barrel bores ranging between ~0.5 to 1.0 mm. The new system is almost complete and is described briefly here, highlighting the new features added since the original MST injector was constructed. Also, the future installation on TJ-II is reviewed.

  9. Demonstration of efficient spin injection and detection in various systems using Fe3O4 based spin injectors

    Directory of Open Access Journals (Sweden)

    Shwetha G. Bhat

    2016-05-01

    Full Text Available Half-metal based spin injector devices for spin injection and detection application have proven to be efficient owing to their enhanced injection and detection efficiency. In this study, we extend the all-electrical spin injection and detection studies into different systems like Si and GaAs using half-metal Fe3O4 as a spin injector in the presence and absence of tunnel barrier MgO. Injection into GaAs is verified using conventional Fe/MgO/GaAs devices. Room temperature spin injection into both p-type and n-type Si is achieved and the spin injection could be observed down to 100K. Obtained spin relaxation time for these n-type and p-type Si at different temperatures agree well with the existing reports. Further, the temperature dependent spin injection and detection is also successfully achieved in Fe3O4/GaAs (n-type Schottky devices, and a comparison study of the results with control experiment using Fe/MgO/GaAs (n-type devices confirm the relaxation to be similar in the GaAs substrate, as expected. Hence, even Fe3O4 material can be effectively used as an efficient spin injector as well as detector, making it an attractive candidate for the room temperature spintronics device applications.

  10. Application of an EGR system in a direct injection diesel engine to reduce NOx emissions

    Science.gov (United States)

    De Serio, D.; De Oliveira, A.; Sodré, J. R.

    2016-09-01

    This work presents the application of an exhaust gas recirculation (EGR) system in a direct injection diesel engine operating with diesel oil containing 7% biodiesel (B7). EGR rates of up to 10% were applied with the primary aim to reduce oxides of nitrogen (NOx) emissions. The experiments were conducted in a 44 kW diesel power generator to evaluate engine performance and emissions for different load settings. The use of EGR caused a peak pressure reduction during the combustion process and a decrease in thermal efficiency, mainly at high engine loads. A reduction of NOx emissions of up to 26% was achieved, though penalizing carbon monoxide (CO) and total hydrocarbons (THC) emissions.

  11. Technologies of bearings systems production from composite materials by polyester resin injection into the closed mold

    Directory of Open Access Journals (Sweden)

    Аnatoliy M. Turenko

    2014-12-01

    Full Text Available An analysis of modern technologies for manufacturing components and bearing systems made of composite materials has been conducted. These technologies are based on the polyester resin injection method and do not require high financial costs in manufacturing. The proposed method, due to the low cost of tooling, is convenient to produce a wide range of items made of composite materials, both in large-scale and single-piece production. Composite materials are intensively used in automotive industry, especially for motor racing vehicles’ parts. These technologies allow to solve the problem of creating ultra-light assemblies for modern car bodies, energy-absorbing passive safety elements and other high-loaded parts. They provide better strength and weight characteristics and better specific energy-output ratio of passive safety elements, as compared to conventional materials (metals and plastics. Considering the above, the most appropriate technology for the automotive industry has been assessed with that choice substantiation.

  12. Initial Results in Power System Identification from Injected Probing Signals Using a Subspace Method

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Ning; Pierre, John W.; Hauer, John F.

    2006-08-01

    In this paper, the authors use the Numerical algorithm for Subspace State Space System IDentification (N4SID) to extract dynamic parameters from phasor measurements collected on the western North American Power Grid. The data were obtained during tests on June 7, 2000, and they represent wide area response to several kinds of probing signals including Low-Level Pseudo-Random Noise (LLPRN) and Single-Mode Square Wave (SMSW) injected at the Celilo terminal of the Pacific HVDC In-tertie (PDCI). An identified model is validated using a cross vali-dation method. Also, the obtained electromechanical modes are compared with the results from Prony analysis of a ringdown and with signal analysis of ambient data measured under similar op-erating conditions. The consistent results show that methods in this class can be highly effective even when the probing signal is small.

  13. Injection Bucket Jitter Compensation Using Phase Lock System at Fermilab Booster

    Energy Technology Data Exchange (ETDEWEB)

    Seiya, K. [Fermilab; Drennan, C. [Fermilab; Pellico, W. [Fermilab; Chaurize, S. [Fermilab

    2017-05-12

    The extraction bucket position in the Fermilab Booster is controlled with a cogging process that involves the comparison of the Booster rf count and the Recycler Ring revolution marker. A one rf bucket jitter in the ex-traction bucket position results from the variability of the process that phase matches the Booster to the Recycler. However, the new slow phase lock process used to lock the frequency and phase of the Booster rf to the Recycler rf has been made digital and programmable and has been modified to correct the extraction notch position. The beam loss at the Recycler injection has been reduced by 20%. Beam studies and the phase lock system will be discussed in this paper.

  14. Upgrade of the SPS Injection Kicker System for the LHC High Luminosity Operation with Heavy Ion Beam

    CERN Document Server

    Kramer, T; Goddard, B; Ducimetière, L; Sermeus, L; Uythoven, J; Velotti, FM

    2014-01-01

    In the context of the LHC High Luminosity Upgrade project a performance upgrade for heavy ions is envisaged. One of the performance limitations is the rise time of the present SPS injection kicker system MKP. A reduction of the rise time for lead ions was studied in line with a modification of the whole injection system. This paper briefly describes the different rise time options studied for an initially proposed dedicated ion kicker system MKP-I, focuses however on a cost effective alternative using the presently installed 12 MKPS magnets connected to a new fast pulse forming line. As only 12 out of the 16 injection kicker magnets would be fast enough to be used in an upgraded system, additional deflection has to be provided by the septa. The beam optics for that variant is highlighted and first requirements for the septum elements are stipulated. The paper concludes with a failure analysis of the proposed scheme.

  15. Design of an acid stimulation system with chlorine dioxide for the treatment of water-injection wells

    Energy Technology Data Exchange (ETDEWEB)

    Cavallaro, A.N.; Baigorria, R.; Curci, E. [Repsol YPF, Buenos Aires, (Argentina)

    2000-06-01

    A method to remove solid residues resulting from formation damage in water-injection wells was presented. The method is based on a chemical stimulation system which uses a treatment fluid comprised of hydrochloric acid and chlorine dioxide. This fluid is more effective than conventional acidizing systems in treating the solid residues that get deposited in fractured reservoirs, particularly when the plugging material contains iron sulfide and bacterial agents. This is because of the high oxidative power of chlorine dioxide. Formation damage is a common occurrence in several secondary recovery oilfields in Argentina, resulting in injectivity losses. Internal or external cake formation is usually the mechanism associated with injection performance. The severity of the damage can be determined by examining the parameters such as particle size, shape and composition, injection rates, pore system properties such as permeability, and pore size. Clean-up treatments raise the injection maintenance costs and water treatment substantially. The system presented here differs from past treatments because the chlorine dioxide is not produced in-situ. Core flooding laboratory tests have been conducted which successfully demonstrate the effectiveness of the system in removing solid residues resulting from formation damage. A pilot study will be conducted in the near future. 7 refs., 1 tab., 7 figs.

  16. A spectrophotometric flow injection system for streptomycin determination in veterinary samples

    Science.gov (United States)

    Frugeri, Pedro Marcos; Lago, Ayla Campos do; Wisniewski, Célio; Luccas, Pedro Orival

    2014-01-01

    In this work a spectrophotometric flow injection analysis system for streptomycin determination in veterinary samples, is being proposed. The method is based on streptomycin alkaline hydrolysis that forms guanidine, followed by the reaction with Fe(II). The colored product has absorption peak at 520 nm. To evaluate and optimize the system parameters, chemometrics tools, such as factorial design, Pareto chart and Doelhert design, were used. The veterinary samples are diluted in water and introduced in the FIA system, therefore no sample preparation is required. The optimized system presented: linear range of 60 up to 1000 mg L-1, limit of detection of 18 mg L-1 and sampling rate of 36 readings per hour. The precision was checked and the CV for veterinary sample readings were always less than 6.5%. The accuracy was studied by comparison with chromatographic method, thus, five samples of pharmaceutical veterinary were determined by HPLC and by the proposed method, and the results are in agreement (t-test, p = 0.05).

  17. Potline dry scrubbing technology : development of an innovative alumina injection system

    Energy Technology Data Exchange (ETDEWEB)

    Vendette, H. [Solios Environnement Inc., Montreal, PQ (Canada); Moras, A. [Alcoa Canada, Deschambault, PQ (Canada); Dando, N.R. [Alcoa Technical Center, Alcoa Center, PA (United States)

    2006-07-01

    This paper presented the first test results of an innovative approach to alumina dry scrubbers used to capture fluoride emissions coming from aluminium electrolysis potlines. The concept behind the development of the new alumina injection system was also presented. The system was created for primary aluminium producers to recover fluoride compounds that are then recycled in the electrolysis cells of the Hall-Heroult potline. This paper described the relationship that exists between the emissions of gaseous fluoride and the fluoride saturation level of the alumina. An efficient air pollution control device was developed in response to concerns regarding fluoride emissions. The challenges facing the integration of this relation into the development of a new generation of alumina dry scrubber was discussed along with the proposed innovative scheme that challenged conventional industry practices. To validate this innovative approach, Solios in partnership with Alcoa Primary Metals, modified one of the Aluminerie de Deschambault's system by providing new temporary equipment to its operating units and submitting the equipment to several test campaigns. During the first trials of the alumina cascade feeding system, reductions in fluoride emissions were about 50 per cent. Although stack emissions account for only 10 to 20 per cent of the total plant fluoride emissions, and are therefore not the primary source of fluoride emissions, such drastic reductions from potline dry scrubbers should help smelter operators to maintain the lowest possible fluoride emissions year round, even during the hottest summer days. 5 refs., 5 figs.

  18. Neutral Beam Injection System for the C-2W Field Reversed Configuration Experiment

    Science.gov (United States)

    Dunaevsky, Alexander; Ivanov, Alexander; Kolmogorov, Vyacheslav; Smirnov, Artem; Korepanov, Sergey; Binderbauer, Michl; TAE Team; BINP Team

    2016-10-01

    C-2U Field-Reversed Configuration (FRC) experiment proved substantial reduction in turbulence-driven losses via tangential neutral beam injection (NBI) coupled with electrically biased plasma guns at the plasma ends. Under such conditions, highly reproducible, advanced beam-driven FRCs were produced and sustained for times significantly longer (more than 5 ms) than all characteristic plasma decay times without beams. To further improve FRC sustainment and demonstrate the FRC ramp-up, the C-2U experimental device is undergoing a major upgrade. The upgrade, C-2W, will have a new NBI system producing a record total hydrogen beam power of 20 + MW in a 30ms pulse. The NBI system consists of eight positive-ion based injectors featuring flexible, modular design. Four out of eight NBI injectors have a capability to switch the beam energy during a shot from the initial 15 keV to 40 keV at a constant beam current. This feature allows to increase the beam energy and thereby optimize the beam-plasma coupling during the magnetic field ramp up. This presentation provides an overview of the C-2W NBI system, including the design of the switchable energy injectors, layout of the power supply system, and results of the prototype testing.

  19. Superconducting technology for overcurrent limiting in a 25 kA current injection system

    Science.gov (United States)

    Heydari, Hossein; Faghihi, Faramarz; Sharifi, Reza; Poursoltanmohammadi, Amir Hossein

    2008-09-01

    Current injection transformer (CIT) systems are within the major group of the standard type test of high current equipment in the electrical industry, so their performance becomes very important. When designing high current systems, there are many factors to be considered from which their overcurrent protection must be ensured. The output of a CIT is wholly dependent on the impedance of the equipment under test (EUT). Therefore current flow beyond the allowable limit can occur. The present state of the art provides an important guide to developing current limiters not only for the grid application but also in industrial equipment. This paper reports the state of the art in the technology available that could be developed into an application of superconductivity for high current equipment (CIT) protection with no test disruption. This will result in a greater market choice and lower costs for equipment protection solutions, reduced costs and improved system reliability. The paper will also push the state of the art by using two distinctive circuits, closed-core and open-core, for overcurrent protection of a 25 kA CIT system, based on a flux-lock-type superconducting fault current limiter (SFCL) and magnetic properties of high temperature superconducting (HTS) elements. An appropriate location of the HTS element will enhance the rate of limitation with the help of the magnetic field generated by the CIT output busbars. The calculation of the HTS parameters for overcurrent limiting is also performed to suit the required current levels of the CIT.

  20. High heat flux engineering for the upgraded neutral beam injection systems of MAST-U

    Energy Technology Data Exchange (ETDEWEB)

    Dhalla, F., E-mail: Fahim.dhalla@ccfe.ac.uk; Mistry, S.; Turner, I.; Barrett, T.R.; Day, I.; McAdams, R.

    2015-10-15

    Highlights: • A new Residual Ion Dump (RID) and bend magnet system for the upgraded NBI systems have been designed for the 5 s MAST-U pulse requirements. • Design scoping was performed using numerical ion-tracing analysis software (MAGNET and OPERA codes). • A more powerful bending magnet will separate the residual ions into full, half and third energy components. • Three separate CuCrZr dumps spread the power loading resulting in acceptable power footprints. • FE thermo-mechanical analyses using ANSYS to validate the designs against the ITER SDC-IC code. • New bend magnet coils, yoke and CuCrZr water-cooled plates are in the procurement phase. - Abstract: For the initial phase of MAST-U operation the two existing neutral beam injection systems will be used, but must be substantially upgraded to fulfil expected operational requirements. The major elements are the design, manufacture and installation of a bespoke bending magnet and Residual Ion Dump (RID) system. The MAST-design full energy dump is being replaced with new actively-cooled full, half and third energy dumps, designed to receive 2.4 MW of ion power deflected by an iron-cored electromagnet. The main design challenge is limited space available in the vacuum vessel, requiring ion-deflection calculations to ensure acceptable heat flux distribution on the dump panels. This paper presents engineering and physics analysis of the upgraded MAST beamlines and reports the current status of manufacture.

  1. Effect of Injection Velocity on Structure Part Characteristic in AZ50 Die Casting Process with High Vacuum System

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    When diecasting large and thin Mg alloy parts, material defects occur, which include porosity, nonuniform mechanical properties, irregular surfaces, and incomplete filling. To resolve these problems, it is necessary to have uniform injection velocities and temperatures as well as control the melt. This study investigated the feasibility of producing large and thin components using a die caster by attaching a high vacuum system. In particular, the effects of injection velocity on surface quality and the mechanical properties of the products were investigated. Hence, an injection velocity scheme and a die structure capable of casting in a vacuum were proposed. As a result, it was found that the critical low injection velocity was 0.2 m/s to produce large thin Mg alloy structures having good mechanical properties.

  2. Study on a small diesel engine with direct injection impinging distribution spray combustion system. Optimum of injection system and combustion chamber; Shototsu kakusan hoshiki kogata diesel kikan ni kansuru kenkyu. Funshakei to nenshoshitsu no saitekika

    Energy Technology Data Exchange (ETDEWEB)

    Fujita, K.; Kato, S.; Saito, T. [Kanazawa Institute of Technology, Ishikawa (Japan); Tanabe, H. [Gunma University, Gunma (Japan)

    1997-10-01

    This study is concerned with a small bore (93mm) diesel engine using impinged fuel spray, named OSKA system. The higher rate of injection show lower smoke emission with higher NOx Emission. The exhaust emission and performance were investigated under different compression ratio with higher rate of injection. The experimental results show that this OSKA system is capable for reducing the smoke emission without the deterioration of NOx emission and fuel consumption compared with the conventional DI diesel engine. 5 refs., 8 figs., 3 tabs.

  3. Impact of physical properties of mixture of diesel and biodiesel fuels on hydrodynamic characteristics of fuel injection system

    Directory of Open Access Journals (Sweden)

    Filipović Ivan M.

    2014-01-01

    Full Text Available One of the alternative fuels, originating from renewable sources, is biodiesel fuel, which is introduced in diesel engines without major construction modifications on the engine. Biodiesel fuel, by its physical and chemical properties, is different from diesel fuel. Therefore, it is expected that by the application of a biodiesel fuel, the characteristic parameters of the injection system will change. These parameters have a direct impact on the process of fuel dispersion into the engine cylinder, and mixing with the air, which results in an impact on the quality of the combustion process. Method of preparation of the air-fuel mixture and the quality of the combustion process directly affect the efficiency of the engine and the level of pollutant emissions in the exhaust gas, which today is the most important criterion for assessing the quality of the engine. The paper presents a detailed analysis of the influence of physical properties of a mixture of diesel and biodiesel fuels on the output characteristics of the fuel injection system. The following parameters are shown: injection pressure, injection rate, the beginning and duration of injection, transformation of potential into kinetic energy of fuel and increase of energy losses in fuel injection system of various mixtures of diesel and biodiesel fuels. For the analysis of the results a self-developed computer program was used to simulate the injection process in the system. Computational results are verified using the experiment, for a few mixtures of diesel and biodiesel fuels. This paper presents the verification results for diesel fuel and biodiesel fuel in particular.

  4. Magnetospheric effects of ion and atom injections by the satellite power system

    Energy Technology Data Exchange (ETDEWEB)

    Chiu, Y.T.; Luhmann, J.G.; Schulz, M.; Cornwall, J.M.

    1980-07-01

    This is the final report of a two-year assessment of magnetospheric effects of the construction and operation of a satellite power system. This assessment effort is based on application of present scientific knowledge rather than on original scientific research. As such, it appears that mass and energy injections of the system are sufficient to modify the magnetosphere substantially, to the extent of possibly requiring mitigation measures for space systems but not to the extent of causing major redirection of efforts and concepts. The scale of the SPS is so unprecedentedly large, however, that these impressions require verification (or rejection) by in-depth assessment based on original scientific treatment of the principal issues. Indeed, it is perhaps appropriate to state that present ignorance far exceeds present knowledge in regard to SPS magnetospheric effects, even though we only seek to define the approximate limits of magnetospheric modifications here. Modifications of the space radiation environment, of the atmospheric airglow background, of the auroral response to solar activity and of the fluctuations in space plasma density are identified to be the principal impacts.

  5. Flow-injection determination of isoniazid using sodium dichloroisocyanurate- and trichloroisocyanuric acid-luminol chemiluminescence systems.

    Science.gov (United States)

    Safavi, A; Karimi, M A; Hormozi Nezhad, M R

    2004-06-01

    A chemiluminescent (CL) method for the determination of isoniazid is described. The method is based on the CL generated during the oxidation of luminol by sodium dichloroisocyanurate (SDCC) and trichloroisocyanuric acid (TCCA) in alkaline medium. It was found that isoniazid greatly enhances this CL intensity when present in the luminol solution. Based on this observation, a new flow-injection CL method for the determination of isoniazid has been proposed in this paper. The detection limits were 2 and 3 ng ml(-1) isoniazid for the SDCC-luminol and TCCA-luminol CL systems, respectively. The relative CL intensity was linear with the isoniazid concentration in the range of 4-100 and 100-200 ng ml(-1) for the SDCC-luminol CL system, and 6-200 and 200-1000 ng ml(-1) for the TCCA-luminol CL system. The results obtained for the assay of pharmaceutical preparations compared well with those obtained by the official methods and demonstrated good accuracy and precision.

  6. Automated dual capillary electrophoresis system with hydrodynamic injection for the concurrent determination of cations and anions

    Energy Technology Data Exchange (ETDEWEB)

    Pham, Thi Thanh Thuy; Mai, Thanh Duc [University of Basel, Department of Chemistry, Spitalstrasse 51, Basel 4056 (Switzerland); Centre for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Nguyen Trai Street 334, Hanoi (Viet Nam); Nguyen, Thanh Dam [Centre for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Nguyen Trai Street 334, Hanoi (Viet Nam); Sáiz, Jorge [Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering – University of Alcalá, Ctra. Madrid-Barcelona km 33.6, Alcalá de Henares, Madrid 28871 (Spain); Pham, Hung Viet, E-mail: phamhungviet@hus.edu.vn [Centre for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Nguyen Trai Street 334, Hanoi (Viet Nam); Hauser, Peter C., E-mail: Peter.Hauser@unibas.ch [University of Basel, Department of Chemistry, Spitalstrasse 51, Basel 4056 (Switzerland)

    2014-09-02

    Highlights: • Concurrent determination of cations and anions was carried out by electrophoretic separation. • Optimized conditions for each class of analystes was possible by using separate capillaries. • Simultaneous hydrodynamic injection was carried out. • Pneumatic actuation was used for flushing and sample handling. • The denitrification of drinking water was successfully demonstrated. - Abstract: The capillary electrophoresis instrument developed for the concurrent determination of cations and anions features two separate capillaries and individual detectors to allow independent optimization for each group of ions. The capillaries are joined in a common injector block. The sample is drawn into the injector with a small membrane pump and automated simultaneous injection into both capillaries is achieved by pressurization of the fluid with compressed air. Flushing of the injector and of the capillaries with the background electrolyte is also carried out automatically by the same means. The buffer consisted of 12 mM histidine and 2 mM 18-crown-6 adjusted to pH 4 with acetic acid and was suitable for the contactless conductivity detection employed. The system was optimized for the determination of cationic NH{sub 4}{sup +} and anionic NO{sub 3}{sup −} and NO{sub 2}{sup −}, and linear calibration curves from about 20 μM up to about 1.5 mM were obtained for these ions. In a test run over 8 h, the reproducibility for the peak areas was within ±7%. For demonstration, the instrument was successfully applied to the concurrent monitoring of the concentrations of the three ions during the biological removal of ammonium from contaminated groundwater in a sequencing batch reactor, where NO{sub 3}{sup −} and NO{sub 2}{sup −} are formed as intermediate products.

  7. Systemic injection of kainic acid differently affects LTP magnitude depending on its epileptogenic efficiency.

    Directory of Open Access Journals (Sweden)

    Luz M Suárez

    Full Text Available Seizures have profound impact on synaptic function and plasticity. While kainic acid is a popular method to induce seizures and to potentially affect synaptic plasticity, it can also produce physiological-like oscillations and trigger some forms of long-term potentiation (LTP. Here, we examine whether induction of LTP is altered in hippocampal slices prepared from rats with different sensitivity to develop status epilepticus (SE by systemic injection of kainic acid. Rats were treated with multiple low doses of kainic acid (5 mg/kg; i.p. to develop SE in a majority of animals (72-85% rats. A group of rats were resistant to develop SE (15-28% after several accumulated doses. Animals were subsequently tested using chronic recordings and object recognition tasks before brain slices were prepared for histological studies and to examine basic features of hippocampal synaptic function and plasticity, including input/output curves, paired-pulse facilitation and theta-burst induced LTP. Consistent with previous reports in kindling and pilocapine models, LTP was reduced in rats that developed SE after kainic acid injection. These animals exhibited signs of hippocampal sclerosis and developed spontaneous seizures. In contrast, resistant rats did not become epileptic and had no signs of cell loss and mossy fiber sprouting. In slices from resistant rats, theta-burst stimulation induced LTP of higher magnitude when compared with control and epileptic rats. Variations on LTP magnitude correlate with animals' performance in a hippocampal-dependent spatial memory task. Our results suggest dissociable long-term effects of treatment with kainic acid on synaptic function and plasticity depending on its epileptogenic efficiency.

  8. Finger-powered microfluidic systems using multilayer soft lithography and injection molding processes.

    Science.gov (United States)

    Iwai, Kosuke; Shih, Kuan Cheng; Lin, Xiao; Brubaker, Thomas A; Sochol, Ryan D; Lin, Liwei

    2014-10-07

    Point-of-care (POC) and disposable biomedical applications demand low-power microfluidic systems with pumping components that provide controlled pressure sources. Unfortunately, external pumps have hindered the implementation of such microfluidic systems due to limitations associated with portability and power requirements. Here, we propose and demonstrate a 'finger-powered' integrated pumping system as a modular element to provide pressure head for a variety of advanced microfluidic applications, including finger-powered on-chip microdroplet generation. By utilizing a human finger for the actuation force, electrical power sources that are typically needed to generate pressure head were obviated. Passive fluidic diodes were designed and implemented to enable distinct fluids from multiple inlet ports to be pumped using a single actuation source. Both multilayer soft lithography and injection molding processes were investigated for device fabrication and performance. Experimental results revealed that the pressure head generated from a human finger could be tuned based on the geometric characteristics of the pumping system, with a maximum observed pressure of 7.6 ± 0.1 kPa. In addition to the delivery of multiple, distinct fluids into microfluidic channels, we also employed the finger-powered pumping system to achieve the rapid formation of both water-in-oil droplets (106.9 ± 4.3 μm in diameter) and oil-in-water droplets (75.3 ± 12.6 μm in diameter) as well as the encapsulation of endothelial cells in droplets without using any external or electrical controllers.

  9. Modeling and investigation of refrigeration system performance with two-phase fluid injection in a scroll compressor

    Science.gov (United States)

    Gu, Rui

    Vapor compression cycles are widely used in heating, refrigerating and air-conditioning. A slight performance improvement in the components of a vapor compression cycle, such as the compressor, can play a significant role in saving energy use. However, the complexity and cost of these improvements can block their application in the market. Modifying the conventional cycle configuration can offer a less complex and less costly alternative approach. Economizing is a common modification for improving the performance of the refrigeration cycle, resulting in decreasing the work required to compress the gas per unit mass. Traditionally, economizing requires multi-stage compressors, the cost of which has restrained the scope for practical implementation. Compressors with injection ports, which can be used to inject economized refrigerant during the compression process, introduce new possibilities for economization with less cost. This work focuses on computationally investigating a refrigeration system performance with two-phase fluid injection, developing a better understanding of the impact of injected refrigerant quality on refrigeration system performance as well as evaluating the potential COP improvement that injection provides based on refrigeration system performance provided by Copeland.

  10. Comparing the survival rate of juvenile Chinook salmon migrating through hydropower systems using injectable and surgical acoustic transmitters

    Energy Technology Data Exchange (ETDEWEB)

    Deng, Z. D.; Martinez, J. J.; Li, H.; Harnish, R. A.; Woodley, C. M.; Hughes, J. A.; Li, X.; Fu, T.; Lu, J.; McMichael, G. A.; Weiland, M. A.; Eppard, M. B.; Skalski, J. R.; Townsend, R. L.

    2017-02-21

    Acoustic telemetry is one of the primary technologies for studying the behavior and survival of fishes throughout the world. The size and performance of the transmitters is still the key limiting factor despite that considerable effort has been expended to understand the biological effects of implantation of acoustic transmitters in yearling and subyearling Chinook salmon. The newly developed injectable transmitter is the first active acoustic tag that can be implanted via injection instead of surgery. It also lasts more than four times longer than the commercially-available transmitters. A two-part field study was conducted to evaluate the performance of the injectable transmitter and its effect on the survival of implanted fish. The injectable transmitter performed well and similarly to the other commercially-available transmitters tested. Snake River subyearling Chinook salmon smolts implanted with the injectable tag had a higher survival probability from release to each of 11 downstream detection arrays than concurrent releases of fish surgically implanted with commercially-available tags. In addition, reach-specific survival estimates were significantly higher for the injectable group in three of the eleven reaches examined. Overall, the injectable group had a 0.263 (SE = 0.017) survival probability over the entire 500 km study area compared to 0.199 (0.012) for the surgically implanted group. The differences in survival may have been caused by warm water temperatures and higher rates of infection experienced by the surgically implanted group due to the presence of sutures acting as an attachment site for pathogens. The reduction in size and ability to implant the new transmitter via injection has further reduced the tag or tagging effect bias associated with studying small fishes. The information gathered with this new technology is helping minimize the impact of dams on fish, leading to more environmentally sustainable energy systems.

  11. Development of a Kingdon ion trap system for trapping externally injected highly charged ions.

    Science.gov (United States)

    Numadate, Naoki; Okada, Kunihiro; Nakamura, Nobuyuki; Tanuma, Hajime

    2014-10-01

    We have developed a Kingdon ion trap system for the purpose of the laboratory observation of the x-ray forbidden transitions of highly charged ions (HCIs). Externally injected Ar(q+) (q = 5-7) with kinetic energies of 6q keV were successfully trapped in the ion trap. The energy distribution of trapped ions is discussed in detail on the basis of numerical simulations. The combination of the Kingdon ion trap and the time-of-flight mass spectrometer enabled us to measure precise trapping lifetimes of HCIs. As a performance test of the instrument, we measured trapping lifetimes of Ar(q+) (q = 5-7) under a constant number density of H2 and determined the charge-transfer cross sections of Ar(q+)(q = 5, 6)-H2 collision systems at binary collision energies of a few eV. It was confirmed that the present cross section data are consistent with previous data and the values estimated by some scaling formula.

  12. Investigation of ecological parameters of four-stroke SI engine, with pneumatic fuel injection system

    Science.gov (United States)

    Marek, W.; Śliwiński, K.

    2016-09-01

    The publication presents the results of tests to determine the impact of using waste fuels, alcohol, to power the engine, on the ecological parameters of the combustion engine. Alternatively fuelled with a mixture of iso- and n-butanol, indicated with "X" and "END, and gasoline and a mixture of fuel and alcohol. The object of the study was a four-stroke engine with spark ignition designed to work with a generator. Motor power was held by the modified system of pneumatic injection using hot exhaust gases developed by Prof. Stanislaw Jarnuszkiewicz, controlled by modern mechatronic systems. Tests were conducted at a constant speed for the intended use of the engine. The subject of the research was to determine the control parameters such as ignition timing, mixture composition and the degree of exhaust gas recirculation on the ecological parameters of the engine. Tests were carried out using partially quality power control. In summary we present the findings of this phase of the study.

  13. Operating characteristics of a new ion source for KSTAR neutral beam injection system.

    Science.gov (United States)

    Kim, Tae-Seong; Jeong, Seung Ho; Chang, Doo-Hee; Lee, Kwang Won; In, Sang-Ryul

    2014-02-01

    A new positive ion source for the Korea Superconducting Tokamak Advanced Research neutral beam injection (KSTAR NBI-1) system was designed, fabricated, and assembled in 2011. The characteristics of the arc discharge and beam extraction were investigated using hydrogen and helium gas to find the optimum operating parameters of the arc power, filament voltage, gas pressure, extracting voltage, accelerating voltage, and decelerating voltage at the neutral beam test stand at the Korea Atomic Energy Research Institute in 2012. Based on the optimum operating condition, the new ion source was then conditioned, and performance tests were primarily finished. The accelerator system with enlarged apertures can extract a maximum 65 A ion beam with a beam energy of 100 keV. The arc efficiency and optimum beam perveance, at which the beam divergence is at a minimum, are estimated to be 1.0 A/kW and 2.5 uP, respectively. The beam extraction tests show that the design goal of delivering a 2 MW deuterium neutral beam into the KSTAR Tokamak plasma is achievable.

  14. Development of a Twin-Screw D-2 Extruder for the ITER Pellet Injection System

    Energy Technology Data Exchange (ETDEWEB)

    Meitner, Steven J [ORNL; Baylor, Larry R [ORNL; Carbajo, Juan J [ORNL; Combs, Stephen Kirk [ORNL; Fehling, Dan T [ORNL; Foust, Charles R [ORNL; McFee, Marshall T [ORNL; McGill, James M [ORNL; Rasmussen, David A [ORNL; Sitterson, R G [ORNL; Sparks, Dennis O [ORNL; Qualls, A L [ORNL

    2009-07-01

    A twin-screw extruder for the ITER pellet injection system is under development at the Oak Ridge National Laboratory. The extruder will provide a stream of solid hydrogen isotopes to a secondary section, where pellets are cut and accelerated with single-stage gas gun into the plasma. A one-fifth ITER scale prototype extruder has been built to produce a continuous solid deuterium extrusion. Deuterium gas is precooled and liquefied before being introduced into the extruder. The precooler consists of a copper vessel containing liquid nitrogen surrounded by a deuterium gas filled copper coil. The liquefier is comprised of a copper cylinder connected to a Cryomech AL330 cryocooler, which is surrounded by a copper coil that the precooled deuterium flows through. The lower extruder barrel is connected to a Cryomech GB-37 cryocooler to solidify the deuterium (at approximate to 15 K) before it is forced through the extruder nozzle. A viewport located below the extruder nozzle provides a direct view of the extrusion. A camera is used to document the extrusion quality and duration. A data acquisition system records the extruder temperatures, torque, and speed, upstream, and downstream pressures. This paper will describe the prototype twin-screw extruder and initial extrusion results.

  15. Injected nanoparticles: the combination of experimental systems to assess cardiovascular adverse effects.

    Science.gov (United States)

    Vlasova, Maria A; Tarasova, Olga S; Riikonen, Joakim; Raula, Janne; Lobach, Anatoly S; Borzykh, Anna A; Smirin, Boris V; Kauppinen, Esko I; Eletskii, Alexander V; Herzig, Karl-Heinz; Salonen, Jarno; Tavi, Pasi; Lehto, Vesa-Pekka; Järvinen, Kristiina

    2014-05-01

    When nanocarriers are used for drug delivery they can often achieve superior therapeutic outcomes over standard drug formulations. However, concerns about their adverse effects are growing due to the association between exposure to certain nanosized particles and cardiovascular events. Here we examine the impact of intravenously injected drug-free nanocarriers on the cardiovasculature at both the systemic and organ levels. We combine in vivo and in vitro methods to enable monitoring of hemodynamic parameters in conscious rats, assessments of the function of the vessels after sub-chronic systemic exposure to nanocarriers and evaluation of the direct effect of nanocarriers on vascular tone. We demonstrate that nanocarriers can decrease blood pressure and increase heart rate in vivo via various mechanisms. Depending on the type, nanocarriers induce the dilation of the resistance arteries and/or change the responses induced by vasoconstrictor or vasodilator drugs. No direct correlation between physicochemical properties and cardiovascular effects of nanoparticles was observed. The proposed combination of methods empowers the studies of cardiovascular adverse effects of the nanocarriers.

  16. Fault Severity Evaluation and Improvement Design for Mechanical Systems Using the Fault Injection Technique and Gini Concordance Measure

    Directory of Open Access Journals (Sweden)

    Jianing Wu

    2014-01-01

    Full Text Available A new fault injection and Gini concordance based method has been developed for fault severity analysis for multibody mechanical systems concerning their dynamic properties. The fault tree analysis (FTA is employed to roughly identify the faults needed to be considered. According to constitution of the mechanical system, the dynamic properties can be achieved by solving the equations that include many types of faults which are injected by using the fault injection technique. Then, the Gini concordance is used to measure the correspondence between the performance with faults and under normal operation thereby providing useful hints of severity ranking in subsystems for reliability design. One numerical example and a series of experiments are provided to illustrate the application of the new method. The results indicate that the proposed method can accurately model the faults and receive the correct information of fault severity. Some strategies are also proposed for reliability improvement of the spacecraft solar array.

  17. Phosphite determination in fertilizers after online sequential sample preparation in a flow injection system.

    Science.gov (United States)

    Dametto, Patrícia Roberta; Franzini, Vanessa Pezza; Gomes Neto, José Anchieta

    2007-07-25

    A flow injection spectrophotometric system is proposed for phosphite determination in fertilizers by the molybdenum blue method after the processing of each sample two times on-line without and with an oxidizing step. The flow system was designed to add sulfuric acid or permanganate solutions alternately into the system by simply displacing the injector-commutator from one resting position to another, allowing the determination of phosphate and total phosphate, respectively. The concentration of phosphite is obtained then by difference between the two measurents. The influence of flow rates, sample volume, and dimension of flow line connecting the injector-commutator to the main analytical channel was evaluated. The proposed method was applied to phosphite determination in commercial liquid fertilizers. Results obtained with the proposed FIA system were not statistically different from those obtained by titrimetry at the 95% confidence level. In addition, recoveries within 94 and 100% of spiked fertilizers were found. The relative standard deviation (n = 12) related to the phosphite-converted-phosphate peak alone was

  18. System approach in the investigation of coolant parametrical oscillations in passive safety injection systems (PSIS)

    Energy Technology Data Exchange (ETDEWEB)

    Proskouriakov, K.N. [Moskovskij Ehnergeticheskij Inst., Moscow (Russian Federation)

    2001-07-01

    The use of thermal-hydraulic computer codes is an important part of the work programme for activities in the field of nuclear power plants (NPP) Safety Research as it will enable to define better the test configuration and parameter range extensions and to extrapolate the results of the small scale experiments towards full scale reactor applications. The CATHARE2, RELAP5, the WCOBRA/TRAC, and APROS codes are the estimate thermal hydraulic codes for the evaluation of large and small break loss of coolant accidents (LOCA). The relatively good agreement experimental data with the calculations have been presented. There was shown also some big mistakes in predicting distribution of flow when two phase are present. Model of parametrical oscillation (P.O.) worked out gives explanation for flow oscillations and indicates that the phenomenon of P.O. appears under certain combination of thermal-hydraulic parameters and structure of heat-removal system. (orig.)

  19. MO-FG-BRA-01: Development of An Image-Guided Dosimetric Planning System for Injectable Brachytherapy Using ELP Nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Lafata, K [Duke University, Durham, North Carolina (United States); Duke University Medical Center, Durham, NC (United States); Schaal, J; Liu, W [Duke University, Durham, North Carolina (United States); Cai, J [Duke University Medical Center, Durham, NC (United States)

    2015-06-15

    injection placement, and an injection volume-tapering technique, could be used to achieve D95% target coverage. Conclusion: We have preliminarily developed a novel planning framework for ELP brachytherapy. Its dosimetry accuracy has been validated against Monte Carlo, and we have started to investigate the potential advantages of injection-based planning. This system, once fully developed, will serve as the technical foundation for our novel approach.

  20. Heme precursor injection is effective for Arthromyces ramosus peroxidase fusion protein production by a silkworm expression system.

    Science.gov (United States)

    Hayashi, Kounosuke; Lee, Jae Man; Tomozoe, Yusuke; Kusakabe, Takahiro; Kamiya, Noriho

    2015-10-01

    Recombinant peroxidase from Arthromyces ramosus, fused with domains of antibody-binding proteins, was successfully obtained by a silkworm larvae expression system. The catalytic activity of the fusion peroxidase was increased 6-fold with the injection of 5-aminolevulinic acid into silkworm larvae as a heme precursor. Copyright © 2015 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  1. DURIP: Electrokinetic Injection and Separation System for Analysis of Protein and Peptide Transport, Adsorption and Kinetics Instrumentation Proposal

    Science.gov (United States)

    2015-03-18

    are investigating fundamental protein transport , adsorption, and kinetic interactions using a novel nanofluidics-based platform. Since nanofluidic... Protein and Peptide Transport , Adsorption and Kinetics Instrumentation Proposal The views, opinions and/or findings contained in this report are those of...Injection and Separation System for Analysis of Protein and Peptide Transport , Adsorption and Kinetics Instrumentation Proposal Report Title We requested

  2. Flow injection conductometric system with gas diffusion separation for the determination of Kjeldahl nitrogen in milk and chicken meat.

    Science.gov (United States)

    Junsomboon, Jaroon; Jakmunee, Jaroon

    2008-10-10

    A simple flow injection (FI) conductometric system with gas diffusion separation was developed for the determination of Kjeldahl nitrogen (or proteins) in milk and chicken meat. The sample was digested according to the Kjeldahl standard method and the digest was diluted and directly injected into the donor stream consisting of 4M NaOH. In alkaline medium, ammonium was converted to ammonia, which diffused through the PTFE membrane to dissolve in an acceptor stream (water). Dissociation of ammonia caused a change in conductance of the acceptor solution, which was linearly proportional to the concentration of ammonium originally present in the injected solution. A conductometric flow through cell and an amplifier circuit was fabricated, which helped improve sensitivity of the conductometric detection system. With using a plumbing Teflon tape as a gas diffusion membrane and without thermostating control of the system, a linear calibration graph in range of 10-100mgL(-1) N-NH(4) was obtained, with detection limit of 1mgL(-1) and good precision (relative standard deviation of 0.3% for 11 replicate injections of 50mgL(-1) N-NH(4)). The developed method was validated by the standard Kjeldahl distillation/titration method for the analysis of milk and chicken meat samples. The proposed system had sample throughput of 35h(-1) and consumed much smaller amounts of chemical than the standard method (275mg vs 17.5g of NaOH per analysis, respectively).

  3. Spectrophotometric determination of phosphorus in iron alloys employing a flow injection system

    Directory of Open Access Journals (Sweden)

    Gervasio Ana P. G.

    2001-01-01

    Full Text Available A flow-injection procedure for spectrophotometric determination of phosphorus in electrolytic iron and iron alloys is proposed. The method is based on the ammonium molybdate reaction followed by stannous chloride reduction in acidic medium. In order to circumvent the severe interference caused by the major constituents such as Fe(III and Cr(III, a mini-column packed with AG50W-X8 resin was coupled to the manifold. A sample throughput of 40 determinations per hour, a dynamical range from P 0.25 to 6.00 mg L-1, a reagent consumption of 25 mg ammonium molybdate and 2 mg stannous chloride per determination, and a relative standard deviation < 1% (n = 10 for a typical sample with 2.20 mg L-1 P were achieved. Three different types of samples were used to evaluate system performance. Accuracy was assessed by comparing the results with certified values and no significant difference at 95 % confidence level was observed.

  4. Study of the various factors influencing deposit formation and operation of gasoline engine injection systems

    Science.gov (United States)

    Stepien, Z.

    2016-09-01

    Generally, ethanol fuel emits less pollutants than gasoline, it is completely renewable product and has the potential to reduce greenhouse gases emission but, at the same time can present a multitude of technical challenges to engine operation conditions including creation of very adverse engine deposits. These deposits increasing fuel consumption and cause higher exhaust emissions as well as poor performance in drivability. This paper describes results of research and determination the various factors influencing injector deposits build-up of ethanol-gasoline blends operated engine. The relationship between ethanol-gasoline fuel blends composition, their treatment, engine construction as well as its operation conditions and fuel injectors deposit formation has been investigated. Simulation studies of the deposit formation endanger proper functioning of fuel injection system were carried out at dynamometer engine testing. As a result various, important factors influencing the deposit creation process and speed formation were determined. The ability to control of injector deposits by multifunctional detergent-dispersant additives package fit for ethanol-gasoline blends requirements was also investigated.

  5. Corrosion of carbon steel by bacteria from North Sea offshore seawater injection systems: laboratory investigation.

    Science.gov (United States)

    Stipanicev, Marko; Turcu, Florin; Esnault, Loïc; Rosas, Omar; Basseguy, Régine; Sztyler, Magdalena; Beech, Iwona B

    2014-06-01

    Influence of sulfidogenic bacteria, from a North Sea seawater injection system, on the corrosion of S235JR carbon steel was studied in a flow bioreactor; operating anaerobically for 100days with either inoculated or filtrated seawater. Deposits formed on steel placed in reactors contained magnesium and calcium minerals plus iron sulfide. The dominant biofilm-forming organism was an anaerobic bacterium, genus Caminicella, known to produce hydrogen sulfide and carbon dioxide. Open Circuit Potentials (OCP) of steel in the reactors was, for nearly the entire test duration, in the range -800corrosion rate, expressed as 1/(Rp/Ω), was lower in the inoculated seawater though they varied significantly on both reactors. Initial and final corrosion rates were virtually identical, namely initial 1/(Rp/Ω)=2×10(-6)±5×10(-7) and final 1/(Rp/Ω)=1.1×10(-5)±2.5×10(-6). Measured data, including electrochemical noise transients and statistical parameters (0.0545), suggested pitting on steel samples within the inoculated environment. However, the actual degree of corrosion could neither be directly correlated with the electrochemical data and nor with the steel corrosion in the filtrated seawater environment. Further laboratory tests are thought to clarify the noticed apparent discrepancies. © 2013.

  6. Medroxyprogesterone Injection

    Science.gov (United States)

    Medroxyprogesterone intramuscular (into a muscle) injection and medroxyprogesterone subcutaneous (under the skin) injection are used to prevent pregnancy. Medroxyprogesterone subcutaneous injection is also used to treat endometriosis (a condition in which ...

  7. Pentamidine Injection

    Science.gov (United States)

    Pentamidine injection is used to treat pneumonia caused by a fungus called Pneumocystis carinii. It is in ... Pentamidine injection comes as powder to be mixed with liquid to be injected intramuscularly (into a muscle) ...

  8. Beam injection into RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, W.; Hahn, H.; MacKay, W.W.; Satogata, T.; Tsoupas, N.; Zhang, W.

    1997-07-01

    During the RHIC sextant test in January 1997 beam was injected into a sixth of one of the rings for the first time. The authors describe the injection zone and its bottlenecks. They report on the commissioning of the injection system, on beam based measurements of the kickers and the application program to steer the beam.

  9. Modeling of the flow continuum and optimal design of control-oriented injection systems in liquid composite molding processes

    Science.gov (United States)

    Gokce, Ali

    Several methodologies are presented in this dissertation that aim to ensure successful filling of the mold cavity consistently, during the mold filling stage of Liquid Composite Molding (LCM) processes such as Resin Transfer Molding (RTM), Vacuum Assisted Resin Transfer Molding (VARTM) and Seemann Composites Resin Infusion Molding (SCRIMP). Key parameters that affect the resin flow in the mold cavity can be divided into two main groups as continuum-related parameters and injection-related parameters. Flow continuum, which consists of all the spaces resin can reach in the mold cavity, has two major components: the porous medium, which is made up of the fiber reinforcements, and the flow channels that are introduced into the flow continuum unintentionally and offer an easy flow path to the resin. The properties that characterize the porous medium and the unintentional flow channels are continuum-related parameters. The injection-related parameters include resin injection locations (gates), resin injection conditions and air drainage locations (vents). Modeling the flow continuum is crucial in predicting the resin flow in the mold cavity. In this study, permeability, the key property of the porous medium, is predicted using the Method of Cells, a proven method to predict macroscopic properties of heterogeneous materials. Unintentional flow channels, which are also called racetracking channels, are modeled using a probabilistic approach. Injection-related parameters are the key tools to influence the resin flow in the mold cavity. In this study, Branch and Bound Search is modified for single gate optimization. Due to its pertinence to injection system design, the parameters that govern gate effectiveness in steering the resin advance are studied. A combinatorial search algorithm is proposed for vent optimization. Vent optimization and gate optimization algorithms are integrated for simultaneous gate and vent optimization. Overall, these methodologies reduce the cycle

  10. Dimensioning of components of fuel injection systems for very high pressure applications; Auslegung von Dieseleinspritzkomponenten fuer Hoechstdruckanwendungen

    Energy Technology Data Exchange (ETDEWEB)

    Scheffold, Andreas; Rauscher, Thomas; Haeussler, Peter; Nonhoff, Sven; Maehrle, Thomas [Bosch GmbH, Stuttgart (Germany)

    2009-07-01

    Due to the aggravation of the exhaust emission standards and the reduction of the fuel consumption the available injection systems have to be developed with regard to higher injection pressures. Based on the method to ensure the fatigue strength under operational conditions to release the parts for serial production, the dimensioning concept in the early phase of the development will be presented. The main emphasis will be the presentation how to simulate pressure load collectives and the approach how to derivative standardized stress number curves. (orig.)

  11. Effect of dopamine injection on the hemocyte count and prophenoloxidase system of the white shrimp Litopenaeus vannamei

    Science.gov (United States)

    Pan, Luqing; Hu, Fawen; Zheng, Debin

    2011-09-01

    Effects of dopamine injection on the hemocyte count, phenoloxidase activity, serine proteinase activity, proteinase inhibitor activity and α2-macroglobulin-like activity in L. vannamei were studied. Results showed that dopamine injection resulted in a significant effect on the parameters measured ( P proteinase inhibitor activity reached the minimum in 3 h, and α2-macroglobulin-like activity reached the maximum in 3 h, and all the three parameters became stable after 12 h. The results suggest that the activating mechanisms of the proPO system triggered by dopamine are different from those triggered by invasive agents or spontaneously activated under a normal physical condition.

  12. Injection and extraction computer control system HIRFL-SSC The HIRFL-SSC is stated for Heavy Ion Research Facility of Lanzhou-Separated Sector Cyclotron

    CERN Document Server

    Zhang Wei; Chen Yun; Zhang Xia; Hu Jian Jun; Xu Xing Ming

    2002-01-01

    The injection and extraction computer control system of HIRFL-SSC (Heavy Ion Research Facility of Lanzhou-Separated Sector Cyclotron) have been introduced. Software is described briefly. Hardware structure is mainly presented. The computer control system realize that the adjustment of injection and extraction can done by PC and operate interface is Windows style. The system can make the adjustment convenient and veracious

  13. H$^{-}$ painting injection system for the JKJ 3 GeV high-intensity proton synchrotron

    CERN Document Server

    Sakai, I; Irie, Y; Ishi, Y; Machida, S; Noda, F; Shigaki, K; Shimada, T; Sugai, I; Takeda, Y; Watanabe, Y; Yamamoto, K

    2002-01-01

    The JAERI KEK Joint Project 3 GeV proton synchrotron is designed to accelerate 8.3*l0/sup 13/ protons per pulse at a 25 Hz repetition rate. The incoming beam emittance of the 400 MeV linac is 4 pi .mm.mrad and the acceptance in the 3 GeV synchrotron is 324 pi .mm.mrad in both the horizontal and vertical planes. Painting injection is designed to realize a uniform distribution of charged particles in real space. The bump orbit for painting injection is designed to have a full acceptance of the circulating orbit through the injection period. A full-acceptance bump orbit will enable both correlated and anticorrelated painting injection. (4 refs).

  14. Onset of liquid droplet entrainment on a direct vessel injection system for APR1400

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Han-sol; Lee, Jae-Young [Handong Global University, Pohang (Korea, Republic of); Kim, Jong-Rok; Euh, Dong-Jin [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    In this research, a series of visualization works was conducted to understand droplet entrainment of the flow pattern generated in direct vessel injection system(DVI) of Korea nuclear power plant, APR 1400. In the emergency situation of a nuclear power plant, reliability of DVI cooling can be an important issue. It is known that, the amount and the rate of entrainment during the DVI cooling process can significantly affect the total heat removal. To visualize the film Reynolds number closely related with onset of droplet entrainment induced by falling film flow and lateral air flow in a small gap, confocal chromatic sensing method for measuring accurately film thickness and depth averaging particle image velocimetry for film velocity were used. The results have been post processed 4G Insight software. By measuring two dimensional film Reynolds number, we can predict the onset of droplet entrainment and obtain visible breakup region intuitively. To visualize the droplet entrainment induced by falling film flow and lateral air flow in a small gap, shadowgraph method with CCD camera (2200fps, 1280 pixel X 800 pixel, ) on coated plate with super water-repellent agent was used. The results have been post processed using 4G Insight software. By measuring two dimensional film Reynolds number, we can predict the onset of droplet entrainment and obtain visible breakup region intuitively. By adopting both super hydrophobic coating method and shadowgraph method, entrainment in a narrow gap was successfully visualized that has rarely performed before and meaningful results for DVI system research fields have been made.

  15. Development of a Design Tool for Planning Aqueous Amendment Injection Systems Soluble Substrate Design Tool

    Science.gov (United States)

    2012-06-01

    injection with water to distribute the soluble substrate throughout the treatment zone. Once injected, the soluble substrate is fermented molecular...hydrogen (H2) and acetate by common subsurface microorganisms. This H2 and acetate are then used as electron donors for anaerobic biodegradation of the... fermentable organic substrate is diluted with water and distributed throughout the target treatment zone. The soluble substrate is fermented to molecular

  16. Smart gelation of chitosan solution in the presence of NaHCO3 for injectable drug delivery system.

    Science.gov (United States)

    Liu, Li; Tang, Ximin; Wang, Yuanyuan; Guo, Shengrong

    2011-07-29

    In situ gelling systems are attractive as injectable vehicles for drug delivery. The present work described a novel gelation process of acidic chitosan solution in the presence of sodium bicarbonate (NaHCO(3)). The NaHCO(3) concentration played an important role in this gelling system. When it came within the appropriate range, the chitosan/NaHCO(3) system would stay at sol state in certain condition and showed sol-gel transition from the top to the bottom after heating. The rheological properties of the gelling system, as well as the morphology and erosion behavior of the formed chitosan hydrogels were evaluated as a function of the NaHCO(3) concentration in sols. The hydrogels showed porous morphologies with some diversification depending on the NaHCO(3) concentration, which also affected their erosion behaviors and drug release rates. Moreover, the gelation mechanism of such chitosan/NaHCO(3) system was studied and proposed as the formation of three-dimensional chitosan network with physical junctions thanks to the deprotonation of -NH(3)(+) in chitosan accompanying with the gradual neutralization between HCO(3)(-) and acid. In vivo gelation test was also performed by the dorsal subcutaneous injection of chitosan/NaHCO(3) solution in rat. The formation of in situ gels suggested such system promising applications in injectable drug delivery system.

  17. Employing injection-locked FP LDs to set up a hybrid CATV/MW/MMW WDM light wave transmission system.

    Science.gov (United States)

    Lin, Chun-Yu; Lu, Hai-Han; Li, Chung-Yi; Wu, Po-Yi; Peng, Peng-Chun; Jhang, Tai-Wei; Lin, Che-Yu

    2014-07-01

    A hybrid cable television (CATV)/microwave (MW)/millimeter-wave (MMW) wavelength-division-multiplexing (WDM) light wave transmission system based on injection-locked Fabry-Perot laser diodes (FP LDs) is proposed and demonstrated. Different from conventional hybrid WDM light wave transmission systems, which need wavelength-selected distributed feedback laser diodes to support various services, the proposed systems employ injection-locked FP LDs to provide multiple applications. Over a 40 km single-mode fiber transport, impressive performances of carrier-to-noise ratio/composite second-order/composite triple-beat/bit error rate are obtained for 550 MHz CATV/20 GHz MW/40 GHz MMW/60 GHz MMW signal transmissions. Such a hybrid WDM light wave transmission system would be attractive for fiber links to provide broadband integrated services.

  18. Methods, systems and apparatus for optimization of third harmonic current injection in a multi-phase machine

    Science.gov (United States)

    Gallegos-Lopez, Gabriel

    2012-10-02

    Methods, system and apparatus are provided for increasing voltage utilization in a five-phase vector controlled machine drive system that employs third harmonic current injection to increase torque and power output by a five-phase machine. To do so, a fundamental current angle of a fundamental current vector is optimized for each particular torque-speed of operating point of the five-phase machine.

  19. Pre-injection of hyaluronic acid does not affect the systemic effects of intra-articular depot betamethasone injection at the knee joint.

    Science.gov (United States)

    Habib, George; Khatib, Muhamad; Sakas, Fahed; Artul, Suheil; Jabaly-Habib, Haneen

    2017-01-01

    Intra-articular injection (IAI) of both hyaluronic acid (HA) and depot-steroid preparations had the advantage of quick and prolonged favorable effects on pain relief among patients with symptomatic osteoarthritis of the knee (OAK). The effect of IAI of HA on the systemic effects of the intra-articular steroids had not been investigated. Non-selected patients attending the rheumatology clinic with symptomatic OAK who failed NSAIDS and physical therapy were offered an IAI of HA at the knee joint followed 20 min later by an IAI of 1 ml of Celestone Chronodose at the same joint (group 1). Morning serum levels of cortisol were obtained just prior to the IAI and 1, 2 and 8 days later. Demographic, clinical, and laboratory parameters were obtained also from all the patients. Age- and sex-matched group of patients from the same clinic were recruited as a control group (group 2). Mean baseline serum cortisol levels in group 1 was 381 ± 154 mmol/l vs. 376 ± 119 in group 2 (p = 0.954). Morning serum cortisol levels at day 1 and day 2 were 24 ± 6 and 22 ± 6 mmol/l, respectively, in group 1 patients vs. 27 ± 5.8 (p = 0.214) and 25 ± 5.6 mmol/l (p = 0.200), respectively, in group 2. These levels were significantly lower than baseline levels in each group. Morning serum cortisol levels at day 8 in group 1 and group 2 were 349 ± 128 and 314 ± 99 mmol/l, respectively (p = 0.419). Pre-injection of HA at the knee joint did not affect the systemic effect on the hypothalamic-pituitary-adrenal axis of IAI of Celestone Chronodose.

  20. Modeling Single Well Injection-Withdrawal (SWIW) Tests for Characterization of Complex Fracture-Matrix Systems

    Energy Technology Data Exchange (ETDEWEB)

    Cotte, F.P.; Doughty, C.; Birkholzer, J.

    2010-11-01

    The ability to reliably predict flow and transport in fractured porous rock is an essential condition for performance evaluation of geologic (underground) nuclear waste repositories. In this report, a suite of programs (TRIPOLY code) for calculating and analyzing flow and transport in two-dimensional fracture-matrix systems is used to model single-well injection-withdrawal (SWIW) tracer tests. The SWIW test, a tracer test using one well, is proposed as a useful means of collecting data for site characterization, as well as estimating parameters relevant to tracer diffusion and sorption. After some specific code adaptations, we numerically generated a complex fracture-matrix system for computation of steady-state flow and tracer advection and dispersion in the fracture network, along with solute exchange processes between the fractures and the porous matrix. We then conducted simulations for a hypothetical but workable SWIW test design and completed parameter sensitivity studies on three physical parameters of the rock matrix - namely porosity, diffusion coefficient, and retardation coefficient - in order to investigate their impact on the fracture-matrix solute exchange process. Hydraulic fracturing, or hydrofracking, is also modeled in this study, in two different ways: (1) by increasing the hydraulic aperture for flow in existing fractures and (2) by adding a new set of fractures to the field. The results of all these different tests are analyzed by studying the population of matrix blocks, the tracer spatial distribution, and the breakthrough curves (BTCs) obtained, while performing mass-balance checks and being careful to avoid some numerical mistakes that could occur. This study clearly demonstrates the importance of matrix effects in the solute transport process, with the sensitivity studies illustrating the increased importance of the matrix in providing a retardation mechanism for radionuclides as matrix porosity, diffusion coefficient, or retardation

  1. Pharmacokinetic of pseudoephedrine in rat serum with luminol-pepsin chemiluminescence system by flow injection analysis.

    Science.gov (United States)

    Luo, Kai; Li, Yajuan; Zheng, Xiaohui; Song, Zhenghua

    2015-02-01

    Pepsin (Pep) accelerated the electron transferring rate of excited 3-aminophathlate and enhanced luminol-dissolved oxygen chemiluminescence (CL) intensity, and the flow injection (FI) luminol-Pep CL system was first developed. It was found that the CL intensity of luminol-Pep reaction could be remarkably inhibited by pseudoephedrine (PE); the decrement of CL intensity was linear to the logarithm of PE concentration in the range of 0.1∼100.0 nmol L(-1) with a detection limit of 0.03 nmol mL(-1) (3σ). At a flow rate of 2.0 mL min(-1), the complete process including washing and sampling was performed within 40 s, offering a sample throughput of 90 h(-1). This proposed method was successfully applied to determining PE in rat serum for 18 h after intragastric administration with the elimination ratio of 42.34 % and recoveries from 90.3 to 110.6 %. The pharmacokinetic results showed that PE could be rapidly absorbed into serum with peak concentration (C max) of 1.45 ± 0.18 g L(-1) at the time (T max) of 1.49 ± 0.02 h; the absorption half-life (0.35 ± 0.04 h), elimination half-life (1.86 ± 0.24 h), the area under curve (109.81 ± 6.03 mg L(-1) h(-1)), mean residence time (3.82 ± 0.27 h), and elimination rate constant (2.26 ± 0.23 L g(-1) h(-1)) in rats vivo were derived, respectively. The possible CL mechanism of luminol-Pep-PE reaction was discussed by FI-CL, fluorescence, and molecular docking (MD) methods.

  2. Effectiveness and Safety of Computer-controlled Periodontal Ligament Injection System in Endodontic Access to the Mandibular Posterior Teeth

    Institute of Scientific and Technical Information of China (English)

    Quan Jing; Kuo Wan; Xiao-jun Wang; Lin Ma

    2014-01-01

    Objective To evaluate the effectiveness and safety of a computer-controlled periodontal ligament (PDL) injection system to the local soft tissues as the primary technique in endodontic access to mandibular posterior teeth in patients with irreversible pulpitis. Methods A total of 162 Chinese patients who had been diagnosed with irreversible pulpitis in their mandibular posterior teeth without acute infection or inflammation in the periodontal tissues were enrolled in this clinical study. The patients were divided into 3 groups according to the position of the involved tooth:the premolar group (PM, n=38), first molar group (FM, n=66), and second molar group (SM, n=58). All the patients received computer-controlled PDL injection with 4%articaine and 1∶100 000 epinephrine. Immediately after the injection, endodontic access was performed, and the degree of pain during the treatment was evaluated by the patients using Visual Analogue Scale for pain. The success rates were compared among the 3 groups. The responses of local soft tissues were evaluated 3-8 days and 3 weeks after the procedure. Results The overall success rate was 76.5%. There was a significant difference in success rates among the PM, FM, and SM groups (92.1%, 53.0%, 93.1%, respectively;χ2=34.3, P Conclusion The computer-controlled PDL injection system demonstrates both satisfactory anesthetic effects and safety in local soft tissues as primary anesthetic technique in endodontic access to the mandibular posterior teeth in patients with irreversible pulpitis.

  3. Effectiveness and safety of computer-controlled periodontal ligament injection system in endodontic access to the mandibular posterior teeth.

    Science.gov (United States)

    Jing, Quan; Wan, Kuo; Wang, Xiao-jun; Ma, Lin

    2014-03-01

    To evaluate the effectiveness and safety of a computer-controlled periodontal ligament (PDL) injection system to the local soft tissues as the primary technique in endodontic access to mandibular posterior teeth in patients with irreversible pulpitis. A total of 162 Chinese patients who had been diagnosed with irreversible pulpitis in their mandibular posterior teeth without acute infection or inflammation in the periodontal tissues were enrolled in this clinical study. The patients were divided into 3 groups according to the position of the involved tooth: the premolar group (PM, n=38), first molar group (FM, n=66), and second molar group (SM, n=58). All the patients received computer-controlled PDL injection with 4% articaine and 1:100 000 epinephrine. Immediately after the injection, endodontic access was performed, and the degree of pain during the treatment was evaluated by the patients using Visual Analogue Scale for pain. The success rates were compared among the 3 groups. The responses of local soft tissues were evaluated 3-8 days and 3 weeks after the procedure. The overall success rate was 76.5%. There was a significant difference in success rates among the PM, FM, and SM groups (92.1%, 53.0%, 93.1%, respectively; χ² = 34.3, Pcomputer-controlled PDL injection system demonstrates both satisfactory anesthetic effects and safety in local soft tissues as primary anesthetic technique in endodontic access to the mandibular posterior teeth in patients with irreversible pulpitis.

  4. Aperture and Field Constraints for the Vacuum System in the LHC Injection Septa

    CERN Document Server

    Gyr, Marcel; Jiménez, J M; Lacroix, Jean Michel; Sgobba, Stefano

    2005-01-01

    Each beam arriving from the SPS has to pass through five injection septum magnets before being kicked onto the LHC orbit. The injection layout implies that the vacuum chambers for the two circulating beams pass through the septum magnet yokes at a flange distance from the chamber of the beam to be injected. Specially designed vacuum chambers and interconnections provide the required straightness and alignment precision, thus optimising the aperture for both the circulating and injected beams, without affecting the quality of the magnetic dipole field seen by the injected beam. The circulating beams are shielded against the magnetic stray field by using µ-metal chambers with a thickness of 0.9 mm to avoid saturation of the µ-metal (0.8 T), coated with copper (0.4 mm) for impedance reasons and NEG for pumping and electron cloud purposes. A 2 mm gap between the iron yoke and the µ-metal chamber allows an in-situ bake-out at 200°C, based on a polyimide/stainless steel/polyimide sandwich structure with an over...

  5. Preliminary systems-interaction results from the Digraph Matrix Analysis of the Watts Bar Nuclear Power Plant safety-injection systems

    Energy Technology Data Exchange (ETDEWEB)

    Sacks, I.J.; Ashmore, B.C.; Champney, J.M.; Alesso, H.P.

    1983-06-01

    This report provides preliminary results generated by a Digraph Matrix Analysis (DMA) for a Systems Interaction analysis performed on the Safety Injection System of the Tennessee Valley Authority Watts Bar Nuclear Power Plant. An overview of DMA is provided along with a brief description of the computer codes used in DMA.

  6. Preliminary systems-interaction results from the Digraph Matrix Analysis of the Watts Bar Nuclear Power Plant safety-injection systems

    Energy Technology Data Exchange (ETDEWEB)

    Sacks, I.J.; Ashmore, B.C.; Champney, J.M.; Alesso, H.P.

    1983-06-01

    This report provides preliminary results generated by a Digraph Matrix Analysis (DMA) for a Systems Interaction analysis performed on the Safety Injection System of the Tennessee Valley Authority Watts Bar Nuclear Power Plant. An overview of DMA is provided along with a brief description of the computer codes used in DMA.

  7. Novel in vivo imaging analysis of an inner ear drug delivery system: Drug availability in inner ear following different dose of systemic drug injections.

    Science.gov (United States)

    Kanzaki, Sho; Watanabe, Kotaro; Fujioka, Masato; Shibata, Shinsuke; Nakamura, Masaya; Okano, Hirotaka James; Okano, Hideyuki; Ogawa, Kaoru

    2015-12-01

    Systemic application of drugs is commonly used in clinical situations. Some of these drugs are ototoxic. Since there are few studies on in vivo monitoring of drug delivery dynamics, the time course or bioavailability of drugs in the inner ear of live animals following systemic drug application remains unknown. For instance, it is unknown whether the volume of a drug delivered systemically correlates with its inner ear pharmacokinetics. We previously established a new in vivo imaging system to monitor drug delivery in live mice. In the present study, we used this system to compare drug concentration in the inner ear over time after systemic drug injections. We used transgenic GFAP-Luc mice that harbor a firefly luciferase gene expression cassette regulated by 12 kb of murine GFAP promoter and human beta-globin intron 2. Luciferin delivered into the inner ear of these mice reacts with luciferase, and the resulting signals are detected in GFAP-expressing cells in the cochlear nerve. Thus, we assessed in the inner ear the intensity and duration of luciferin/luciferase signals after systemic injections of different volumes of luciferin. An IVIS(®) imaging system was used to observe signals, and these signals were compared to the drug dynamics of luciferin delivered through subcutaneous (sc) injections. The volume of sc-injected drug correlated significantly with photon counts measured in the inner ear. Photons were detected almost immediately after injection, peaking 20 min after injection. Drug concentration did not affect inner ear signals. Luciferin injected systemically appeared in the inner ear between highest and lowest concentration. Drug volume is an important parameter to know if the inner ear requires a higher level of the drug. We observed that it is the volume of a drug-not its concentration-that is the important factor. Indeed, the more volume of a drug injected systemically increased the concentration of that drug in the inner ear. This study provides a

  8. Experimental investigation of hydraulic effects of two-stage fuel injection on fuel-injection systems and diesel combustion in a high-speed optical common-rail diesel engine

    OpenAIRE

    Herfatmanesh, MR; Zhao, H.

    2014-01-01

    In order to meet the ever more stringent emission standards, significant efforts have been devoted to the research and development of internal combustion engines. The requirements for more efficient and responsive diesel engines have led to the introduction and implementation of multiple injection strategies. However, the effects of such injection modes on the hydraulic systems, such as the high-pressure pipes and fuel injectors, must be thoroughly examined and compensated for since the combu...

  9. DIAGNOSTIC CARDIAC CATHETERIZATION USING THE MEDRAD AVANTA FLUID MANAGEMENT SYSTEM AS COMPARED TO THE TRADITIONAL MANUAL INJECTION METHOD

    Energy Technology Data Exchange (ETDEWEB)

    Winniford, Michael D

    2013-02-08

    Nearly 4 million patient procedures performed annually in US cardiac catheterization laboratories utilize contrast media to achieve vessel opacification. The amount of contrast media used is variable and depends on the complexity of the procedure, the method of contrast delivery as well as the skill-level of the operator. Since the total amount of contrast used for each procedure can have both patient safety and economic implications, it is essential for cardiologists to have the ability to control contrast delivery such that optimal angiographic image quality is achieved using the least amount of contrast. Although the complication rate associated with cardiac catheterization remains low, the most common serious complication, contrast-induced nephropathy (CIN), is associated with poor prognosis and a high mortality rate. Numerous interventional strategies for preventing and reducing the severity of CIN have demonstrated varying degrees of clinical benefit, but none has been shown to reliably prevent this serious complication. To date, the most effective approach for reducing the risk of CIN is to properly hydrate the patient and to minimize the amount of contrast media administered. Automated injection systems are intended for use in virtually all cardiac catheterization procedures and have numerous features which can provide potential advantages over traditional methods. With automated injection technology the operator is able to control and precisely monitor contrast delivery. Additionally, the MEDRAD Avanta Fluid Management Injection System utilizes a sterile contrast reservoir which eliminates the need to discard unused contrast in individual opened containers following each procedure. Considering that an average of 50% of opened contrast media is wasted using manual injection methods, this savings can provide a substantial economic benefit. Automated systems also facilitate the use of smaller (5 French) catheter sizes. Precise flow control and the use of

  10. Assessment of steam-injected gas turbine systems and their potential application

    Science.gov (United States)

    Stochl, R. J.

    1982-01-01

    Results were arrived at by utilizing and expanding on information presented in the literature. The results were analyzed and compared with those for simple gas turbine and combined cycles for both utility power generation and industrial cogeneration applications. The efficiency and specific power of simple gas turbine cycles can be increased as much as 30 and 50 percent, respectively, by the injection of steam into the combustor. Steam-injected gas turbines appear to be economically competitive with both simple gas turbine and combined cycles for small, clean-fuel-fired utility power generation and industrial cogeneration applications. For large powerplants with integrated coal gasifiers, the economic advantages appear to be marginal.

  11. Pain and Efficacy Rating of a Microprocessor-Controlled Metered Injection System for Local Anaesthesia in Minor Hand Surgery

    Directory of Open Access Journals (Sweden)

    André S. Nimigan

    2011-01-01

    Full Text Available Purpose. Little attention has been given to syringe design and local anaesthetic administration methods. A microprocessor-controlled anaesthetic delivery device has become available that may minimize discomfort during injection. The purpose of this study was to document the pain experience associated with the use of this system and to compare it with use of a conventional syringe. Methods. A prospective, randomized clinical trial was designed. 40 patients undergoing carpal tunnel release were block randomized according to sex into a two groups: a traditional syringe group and a microprocessor-controlled device group. The primary outcome measure was surgical pain and local anaesthetic administration pain. Secondary outcomes included volume of anaesthetic used and injection time. Results. Analysis showed that equivalent anaesthesia was achieved in the microprocessor-controlled group despite using a significantly lower volume of local anaesthetic (P=.0002. This same group, however, has significantly longer injection times (P<.0001. Pain during the injection process or during surgery was not different between the two groups. Conclusions. This RCT comparing traditional and microprocessor controlled methods of administering local anaesthetic showed similar levels of discomfort in both groups. While the microprocessor-controlled group used less volume, the total time for the administration was significantly greater.

  12. Synchronized droplet size measurements for Coal-Water-Slurry (CWS) diesel sprays of an electronically-controlled fuel injection system

    Science.gov (United States)

    Kihm, K. D.; Terracina, D. P.; Payne, S. E.; Caton, J. A.

    Experiments were completed to study intermittent coal-water slurry (CWS) fuel sprays injected from an electronically-controlled accumulator injector system. A laser diffraction particle analyzing (LDPA) technique was used to measure the spray diameters (Sauter mean diameter, SMD) assuming the Rosin-Rammler two parameter model. In order to ensure an accurate synchronization of the measurement with the intermittent sprays, a new synchronization technique was developed using the light extinction signal as a triggering source for the data taking initiation. This technique allowed measurement of SMD's near the spray tip where the light extinction was low and the data were free from the multiscattering bias. Coal-water slurry fuel with 50% coal loading in mass containing 5 (mu)m mass median diameter coal particulates was considered. Injection pressures ranging from 28 to 110 MPa, two different nozzle orifice diameters, 0.2 ad 0.4 mm, and four axial measurement locations from 60 to 120 mm from the nozzle orifice were studied. Measurements were made for pressurized (2.0 MPa in gauge) and for ambient chamber conditions. The spray SMD showed an increase with the distance of the axial measurement location and with the ambient gas density, and showed a decrease with increasing injection pressure. A correlation of the Sauter mean diameter with the injection conditions was determined. The results were also compared with previous SMD correlations that were available only for diesel fuel sprays.

  13. NUMERICAL ANALYSIS AND VISUALIZATION OF NATURAL GAS JET WITH MULTI-POINT INJECTION SYSTEM

    Institute of Scientific and Technical Information of China (English)

    Xu Boyan; Liang Fuyou; Cai Shaoli

    2005-01-01

    Aiming at the change in intake air flow caused by the injection of natural gas in intake manifold ifone simply replaces the gasoline injector with natural gas injector with the installing position of injector in intake manifold unchanged, and also the reflection of gas toward intake manifold inlet resulted from the impingement between the injected large volumetric natural gas jet and intake valve, an impulsively started natural gas jet injected from a gas injector is characterized as a three-dimensional unsteady compressible viscous turbulent flow, based on which its transient development process is numerically analyzed using general-purpose CFD codes. The predicted velocity vector maps show a vortex, which indicates the occurrence of an unsteady state jet region, is formed downstream of the jet. A schlieren apparatus is utilized to get several groups of visible schlieren photographs of natural gas jets. In the experiment, photographs of natural gas jets taken by a CCD camera are laid in a portrait processor where the shapes, tip penetration distance and injection angles of the gas jets are investigated. Comparisons between predicted results and measurements indicate an excellent agreement between simulations and experimental results.

  14. Electroanalysis of tetracycline using nickel-implanted boron-doped diamond thin film electrode applied to flow injection system.

    Science.gov (United States)

    Treetepvijit, Surudee; Chuanuwatanakul, Suchada; Einaga, Yasuaki; Sato, Rika; Chailapakult, Orawon

    2005-05-01

    The electrochemical analysis of tetracycline was investigated using nickel-implanted boron-doped diamond thin film electrode by cyclic voltammetry and amperometry with a flow injection system. Cyclic voltammetry was used to study the electrochemical oxidation of tetracycline. Comparison experiments were carried out using as-deposited boron-doped diamond thin film electrode (BDD). Nickel-implanted boron-doped diamond thin film electrode (Ni-DIA) provided well-resolved oxidation irreversible cyclic voltammograms. The current signals were higher than those obtained using the as-deposited BDD electrode. Results using nickel-implanted boron-doped diamond thin film electrode in flow injection system coupled with amperometric detection are presented. The optimum potential for tetracycline was 1.55 V versus Ag/AgCl. The linear range of 1.0 to 100 microM and the detection limit of 10 nM were obtained. In addition, the application for drug formulation was also investigated.

  15. [Clinical analysis of Cervus and Cucumis Polypeptide injection based on real world hospital information system].

    Science.gov (United States)

    Sun, Shuai-Ling; Xie, Yan-Ming; Li, Yuan-Yuan; Zhang, Yin; Yi, Dan-Hui; Zhuang, Yan

    2016-11-01

    To analyze the clinical application of Cervus and Cucumis Polypeptide injection in the real world, in order to define the characteristics of clinical drug use and correlation, and provide reference for risk management and further study for Cervus and Cucumis Polypeptide injection. Descriptive analysis and association rules analysis were performed on 37 721 cases using Cervus and Cucumis Polypeptide injection in 26 hospitals nationwide. Cervus and Cucumis Polypeptide injection were mostly adopted by patients aged between 45 and 64(39.84%); mainly used to treat fracture patients in clinic(17 362 cases, 33.97%); 12 mL(41.81%) was the commonest dosage. And the course of treatment mainly lasted for 1-3 days(28 467 cases, 76.26%), which was basically consistent with the description of package insert. In clinic, traditional Chinese medicines, such as blood activating and stasis removing agents and Bushen Zhuanggu agents, were frequently combined with it(rule support degree of 19.38%). Such western medicine as antibiotics and nutritional drugs were frequently combined with it(rule support 39.9%). The main single combined medicine were vitamin C(13 202 cases, 35%), and Jintiange capsule(7 285 cases, 19.31%). The commonly used combined drug pairs were Hulisan capsule and Jintiange capsule (rule support 4.458%), phenobarbital and ceftazidime azole oxazoline(rule support degree of 10.62%). Cervus and Cucumis Polypeptide injection is mainly adopted by elderly patients in clinic, used to treat fracture patients, and often combined with blood activating and stasis removing agents, Bushen Zhuanggu agents, antibiotics, and nutritional medicine to enhance fracture healing. In clinical application, attention shall be paid to drug safety of elderly patients and types of combined medicines and their interaction, so as to prevent adverse reactions. Copyright© by the Chinese Pharmaceutical Association.

  16. Determination of Free and Total Sulfites in Wine using an Automatic Flow Injection Analysis System with Voltammetric Detection

    OpenAIRE

    Gonçalves, Luís Moreira; Pacheco, João Grosso; Magalhães, Paulo Jorge; Rodrigues, José António; Barros, Aquiles Araújo

    2009-01-01

    Abstract An automated Flow Injection Analysis (FIA) system based on a initial analyte separation by gas-diffusion and subsequent determination by square-wave voltammetry (SWV) in a flow cell is proposed for the determination of total and free content of sulphur dioxide (SO2) in wine. The proposed method was compared with two iodometric methodologies (the Ripper method and the simplified method commonly used by the wine industry). The developed method shown repeatability (RSD lower ...

  17. Injection Molding of Titanium Alloy Implant For Biomedical Application Using Novel Binder System Based on Palm Oil Derivatives

    Directory of Open Access Journals (Sweden)

    R. Ibrahim

    2010-01-01

    Full Text Available Problem statement: Titanium alloy (Ti6Al4V has been widely used as an implant for biomedical application. In this study, the implant had been fabricated using high technology of Powder Injection Molding (PIM process due to the cost effective technique for producing small, complex and precision parts in high volume compared with conventional method through machining. Approach: Through PIM, the binder system is one of the most important criteria in order to successfully fabricate the implants. Even though, the binder system is a temporary, but failure in the selection and removal of the binder system will affect on the final properties of the sintered parts. Therefore, the binder system based on palm oil derivative which is palm stearin had been formulated and developed to replace the conventional binder system. Results: The rheological studies of the mixture between the powder and binders system had been determined properly in order to be successful during injection into injection molding machine. After molding, the binder held the particles in place. The binder system had to be removed completely through debinding step. During debinding step, solvent debinding and thermal pyrolysis had been used to remove completely of the binder system. The debound part was then sintered to give the required physical and mechanical properties. The in vitro biocompatibility also was tested using Neutral Red (NR and mouse fibroblast cell lines L-929 for the direct contact assay. Conclusion: The results showed that the properties of the final sintered parts fulfill the Standard Metal Powder Industries Federation (MPIF 35 for PIM parts except for tensile strength and elongation due to the formation of titanium carbide. The in vitro biocompatibility on the extraction using mouse fibroblast cell line L-929 by means of NR assays showed non toxic for the sintered specimen titanium alloy parts.

  18. Design and development of a helium injection system to improve external leakage detection during liquid nitrogen immersion tests

    Science.gov (United States)

    Townsend, Andrew; Mishra, Rakesh

    2016-10-01

    The testing of assemblies for use in cryogenic systems commonly includes evaluation at or near operating (therefore cryogenic) temperature. Typical assemblies include valves and pumps for use in liquid oxygen-liquid hydrogen rocket engines. One frequently specified method of cryogenic external leakage testing requires the assembly, pressurized with gaseous helium (GHe), be immersed in a bath of liquid nitrogen (LN2) and allowed to thermally stabilize. Component interfaces are then visually inspected for leakage (bubbles). Unfortunately the liquid nitrogen will be boiling under normal, bench-top, test conditions. This boiling tends to mask even significant leakage. One little known and perhaps under-utilized property of helium is the seemingly counter-intuitive thermodynamic property that when ambient temperature helium is bubbled through boiling LN2 at a temperature of -195.8 °C, the temperature of the liquid nitrogen will reduce. This paper reports on the design and testing of a novel proof-of-concept helium injection control system confirming that it is possible to reduce the temperature of an LN2 bath below boiling point through the controlled injection of ambient temperature gaseous helium and then to efficiently maintain a reduced helium flow rate to maintain a stabilized liquid temperature, enabling clear visual observation of components immersed within the LN2. Helium saturation testing is performed and injection system sizing is discussed.

  19. Reducing radiation exposure during kyphoplasty with the use of a remote control injection system: a prospective study.

    Science.gov (United States)

    Wang, Jianru; Liu, Hui; Zhang, Kuibo; Li, Bingxue; Yang, Hao; Wang, Hua; Zheng, Zhaomin

    2015-01-15

    A prospective study. To compare surgeons' radiation exposure during kyphoplasty with and without the use of a remote control injection system. Distance from radiation sources is a critical factor for reducing radiation exposure during spine surgery. A newly designed device was used to minimize operators' radiation exposure during kyphoplasty. Forty-four patients admitted for single-level osteoporotic vertebral compression fracture were randomly divided into 2 groups (groups A and B) and treated with kyphoplasty. The remote control injection system was used only in group B. The radiation doses to the surgeon's eyes, thyroid, chest, and right wrist were recorded with 4 unprotected radiometers simultaneously. Operation time, fluoroscopic time, cement amount, patient-reported pre- and postoperative visual analogue scale scores for pain, and complications were recorded. For group A, the radiation doses at the eyes, thyroid, and right wrist were 1.132 ± 0.104 mSv, 0.647 ± 0.049 mSv, 0.578 ± 0.056 mSv, and 1.877 ± 0.214 mSv, respectively; for Group B, these doses were 0.257 ± 0.067 mSv, 0.201 ± 0.049 mSv, 0.145 ± 0.033 mSv, and 0.353 ± 0.046 mSv, respectively (P remote control injection system can significantly reduce surgeons' radiation exposure without affecting the efficiency of procedures.

  20. Ignition assist systems for direct-injected, diesel cycle, medium-duty alternative fuel engines: Final report phase 1

    Energy Technology Data Exchange (ETDEWEB)

    Chan, A.K.

    2000-02-23

    This report is a summary of the results of Phase 1 of this contract. The objective was to evaluate the potential of assist technologies for direct-injected alternative fuel engines vs. glow plug ignition assist. The goal was to demonstrate the feasibility of an ignition system life of 10,000 hours and a system cost of less than 50% of the glow plug system, while meeting or exceeding the engine thermal efficiency obtained with the glow plug system. There were three tasks in Phase 1. Under Task 1, a comprehensive review of feasible ignition options for DING engines was completed. The most promising options are: (1) AC and the ''SmartFire'' spark, which are both long-duration, low-power (LDLP) spark systems; (2) the short-duration, high-power (SDHP) spark system; (3) the micropilot injection ignition; and (4) the stratified charge plasma ignition. Efforts concentrated on investigating the AC spark, SmartFire spark, and short-duration/high-power spark systems. Using proprietary pricing information, the authors predicted that the commercial costs for the AC spark, the short-duration/high-power spark and SmartFire spark systems will be comparable (if not less) to the glow plug system. Task 2 involved designing and performing bench tests to determine the criteria for the ignition system and the prototype spark plug for Task 3. The two most important design criteria are the high voltage output requirement of the ignition system and the minimum electrical insulation requirement for the spark plug. Under Task 3, all the necessary hardware for the one-cylinder engine test was designed. The hardware includes modified 3126 cylinder heads, specially designed prototype spark plugs, ignition system electronics, and parts for the system installation. Two 3126 cylinder heads and the SmartFire ignition system were procured, and testing will begin in Phase 2 of this subcontract.

  1. Effects of preheating of crude palm oil (CPO) on injection system, performance and emission of a diesel engine

    Energy Technology Data Exchange (ETDEWEB)

    Bari, S.; Lim, T.H.; Yu, C.W. [Universiti Sains Malaysia, School of Mechanical Engineering, Penang (Malaysia)

    2002-11-01

    Crude palm oil (CPO) is one of the vegetable oils that have potential for use as fuels for diesel engines. CPO is renewable, and is safe and easy to handle. However, at room temperature (30-32 deg C) CPO has a viscosity about 10 times higher than that of diesel. To lower CPO's viscosity to the level of diesel's viscosity, a heating temperature of at least 92 deg C is needed. At this temperature, there is a concern that the close-fitting parts of the injection system might be affected. This study focused on finding out the effects of preheating of fuel on the injection system utilising a modified method of friction test, which involves injecting fuel outside the combustion chamber during motoring. Results show that preheating of CPO lowered CPO's viscosity and provided smooth fuel flow, but did not affect the injection system, even heating up to 100 deg C. Nevertheless, heating up to such a high temperature offered no benefits in terms of engine performance. However, heating is necessary for smooth flow and to avoid fuel filter clogging. Both can be achieved by heating CPO to 60 deg C. Combustion analyses comparisons between CPO and diesel found that CPO produced a higher peak pressure of 6%, a shorter ignition delay of 2.6 deg, a lower maximum heat release rate and a longer combustion period. Over the entire load range, CPO combustion produced average CO and NO emissions that were 9.2 and 29.3% higher, respectively, compared with those from diesel combustion. (Author)

  2. Doripenem Injection

    Science.gov (United States)

    ... injection is in a class of medications called carbapenem antibiotics. It works by killing bacteria.Antibiotics such ... if you are allergic to doripenem injection; other carbapenem antibiotics such as imipenem/cilastatin (Primaxin) or meropenem ( ...

  3. Methotrexate Injection

    Science.gov (United States)

    Methotrexate injection is used alone or in combination with other medications to treat gestational trophoblastic tumors (a ... in bones) after surgery to remove the tumor. Methotrexate injection is also used to treat severe psoriasis ( ...

  4. Bendamustine Injection

    Science.gov (United States)

    Bendamustine injection is used to treat chronic lymphocytic leukemia (CLL; a type of cancer of the white ... injection. You should use birth control to prevent pregnancy in yourself or your partner during your treatment ...

  5. Caspofungin Injection

    Science.gov (United States)

    Caspofungin injection is used in adults and children 3 months of age and older to treat yeast ... people with a weakened ability to fight infection. Caspofungin injection is in a class of antifungal medications ...

  6. Temozolomide Injection

    Science.gov (United States)

    Temozolomide is used to treat certain types of brain tumors. Temozolomide is in a class of medications called alkylating ... Temozolomide injection comes as a powder to be added to fluid and injected over 90 minutes intravenously ( ...

  7. Pembrolizumab Injection

    Science.gov (United States)

    Pembrolizumab injection is used to treat melanoma (a type of skin cancer) that cannot be treated with ... who have a specific type of melanoma tumor. Pembrolizumab injection is also used to treat a certain ...

  8. Lacosamide Injection

    Science.gov (United States)

    ... injection is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in ... older (about 1 in 500 people) who took anticonvulsants like lacosamide injection to treat various conditions during ...

  9. Midazolam Injection

    Science.gov (United States)

    ... injection is in a class of medications called benzodiazepines. It works by slowing activity in the brain ... breast-feeding.talk to your doctor about the risks and benefits of receiving midazolam injection if you ...

  10. Paclitaxel Injection

    Science.gov (United States)

    ... with other medications. Paclitaxel injection manufactured with polyoxyethylated castor oil is used to treat ovarian cancer (cancer that ... cancer, and lung cancer. Paclitaxel injection with polyoxyethylated castor oil is also used to treat Kaposi's sarcoma (a ...

  11. Etanercept Injection

    Science.gov (United States)

    ... will be using the prefilled syringe or automatic injection device, tell your doctor if you or the person who will be injecting the medication for you are allergic to rubber or latex.tell your doctor and pharmacist what ...

  12. Cyclosporine Injection

    Science.gov (United States)

    Cyclosporine injection is used with other medications to prevent transplant rejection (attack of the transplanted organ by ... who have received kidney, liver, and heart transplants. Cyclosporine injection should only be used to treat people ...

  13. Estrogen Injection

    Science.gov (United States)

    The estradiol cypionate and estradiol valerate forms of estrogen injection are used to treat hot flushes (hot ... should consider a different treatment. These forms of estrogen injection are also sometimes used to treat the ...

  14. Cefotaxime Injection

    Science.gov (United States)

    Cefotaxime injection is used to treat certain infections caused by bacteria including pneumonia and other lower respiratory ... skin, blood, bone, joint, and urinary tract infections. Cefotaxime injection may also be used before surgery, and ...

  15. Effects of thermoacoustic oscillations on spray combustion dynamics with implications for lean direct injection systems

    Science.gov (United States)

    Chishty, Wajid Ali

    Thermoacoustic instabilities in modern high-performance, low-emission gas turbine engines are often observable as large amplitude pressure oscillations and can result in serious performance and structural degradations. These acoustic oscillations can cause oscillations in combustor through-flows and given the right phase conditions, can also drive unsteady heat release. To curb the potential harms caused by the existence of thermoacoustic instabilities, recent efforts have focused on the active suppression of these instabilities. Intuitively, development of effective active combustion control methodologies is strongly dependent on the knowledge of the onset and sustenance of thermoacoustic instabilities. Specially, non-premixed spray combustion environment pose additional challenges due to the inherent unstable dynamics of sprays. The understanding of the manner in which the combustor acoustics affect the spray characteristics, which in turn result in heat release oscillation, is therefore, of paramount importance. The experimental investigations and the modeling studies conducted towards achieving this knowledge have been presented in this dissertation. Experimental efforts comprise both reacting and non-reacting flow studies. Reacting flow experiments were conducted on a overall lean direct injection, swirl-stabilized combustor rig. The investigations spanned combustor characterization and stability mapping over the operating regime. The onset of thermoacoustic instability and the transition of the combustor to two unstable regimes were investigated via phase-locked chemiluminescence imaging and measurement and phase-locked acoustic characterization. It was found that the onset of the thermoacoustic instability is a function of the energy gain of the system, while the sustenance of instability is due to the in-phase relationship between combustor acoustics and unsteady heat release driven by acoustic oscillations. The presence of non-linearities in the system

  16. The role of lipopolysaccharide injected systemically in the reactivation of collagen-induced arthritis in mice

    Science.gov (United States)

    Yoshino, Shin; Ohsawa, Motoyasu

    2000-01-01

    We investigated the role of bacterial lipopolysaccharide (LPS) in the reactivation of autoimmune disease by using collagen-induced arthritis (CIA) in mice in which autoimmunity to the joint cartilage component type II collagen (CII) was involved.CIA was induced by immunization with CII emulsified with complete Freund's adjuvant at the base of the tail (day 0) followed by a booster injection on day 21. Varying doses of LPS from E. coli were i.p. injected on day 50.Arthritis began to develop on day 25 after immunization with CII and reached a peak on day 35. Thereafter, arthritis subsided gradually but moderate joint inflammation was still observed on day 50. An i.p. injection of LPS on day 50 markedly reactivated arthritis on a dose-related fashion. Histologically, on day 55, there were marked oedema of synovium which had proliferated by the day of LPS injection, new formation of fibrin, and intense infiltration of neutrophils accompanied with a large number of mononuclear cells. The reactivation of CIA by LPS was associated with increases in anti-CII IgG and IgG2a antibodies as well as various cytokines including IL-12, IFN-γ, IL-1β, and TNF-α. LPS from S. enteritidis, S. typhimurium, and K. neumoniae and its component, lipid A from E. coli also reactivated the disease. Polymyxin B sulphate suppressed LPS- or lipid A-induced reactivation of CIA.These results suggest that LPS may play an important role in the reactivation of autoimmune joint inflammatory diseases such as rheumatoid arthritis in humans. PMID:10742285

  17. Single bunch injection system for storage ring FEL using an rf photoinjector

    Science.gov (United States)

    O'Shea, P. G.; Lancaster, J. A.; Madey, J. M. J.; Sachtschale, R.; Jones, R.

    1997-05-01

    RF photoinjectors have gained acceptance as the source of choice for high-brightness electron accelerators, but have been quite expensive to build and difficult to operate. In this paper we describe the successful operation of an inexpensive, simple and reliable rf photoinjector suitable for single bunch injection into storage rings. For optimum storage ring FEL and Compton Backscatter performance, we require that the electrons be injected to specified ring rf buckets and no others. The injector-linac electron gun is a single-cell s-band rf gun with a LaB6 cathode. The gun is followed by an a-magnet momentum filter and buncher. The LaB6 cathode can be operated in a pure thermionic mode, a laser switched photoemission mode, or in a combined mode. The laser is a near-UV TEA nitrogen laser with a 600 ps pulse, and 0-50 Hz repetition rate. We routinely inject 0.1 nC bunches at 270 MeV. The ratio of charge in the primary ring bucket to that in the other buckets is better than 1000.

  18. Ustekinumab Injection

    Science.gov (United States)

    ... Do not inject into an area where the skin is tender, bruised, red, or hard or where you have scars or stretch marks.Your doctor or pharmacist will ... injection.you should know that ustekinumab injection may decrease your ability ... new or changing skin lesions, minor infections (such as open cuts or ...

  19. Ranitidine Injection

    Science.gov (United States)

    Ranitidine injection comes as a solution (liquid) to be mixed with another fluid and injected intravenously (into a vein) over 5 to 20 minutes. Ranitidine may also be injected into a muscle. It is usually given every 6 to 8 hours, but may also be given ...

  20. Field evaluation of the accuracy of vaccine deposition by two different commercially available in ovo injection systems.

    Science.gov (United States)

    Williams, C J; Hopkins, B A

    2011-01-01

    The location of injection and vaccine deposition in ovo is known to be critical to the efficacy of Marek's disease (MD) vaccine protection against MD viral challenge. Vaccine deposition into the amniotic sac or a s.c. or i.m. site of the embryo is required for MD vaccine efficacy. Vaccine deposition into the air cell or allantoic fluid results in chicks that are not adequately protected against subsequent MD viral challenge. A study was conducted in 2 commercial broiler hatcheries to evaluate the ability of 2 in ovo injection systems, the Embrex Inovoject system (Pfizer Poultry Health, Research Triangle Park, NC) and the Intelliject system (Avitech, Salisbury, MD; distributed by Merial Ltd., Gainesville, GA) to deliver a vaccine approved for use in ovo accurately and properly. A standard MD vaccine diluent mixed with a protein-staining dye was delivered through each machine to simulate in ovo vaccination. The location of the dye within the egg determined whether the vaccine was delivered correctly. Each egg was also evaluated for normal embryo development (normal eggs). Correct vaccine delivery included eggs in which the vaccine was injected into the amniotic sac or into s.c. or i.m. regions of the embryo. Incorrect vaccine delivery was defined as delivery into the air cell; allantoic sac; any combinations including air cell or allantois; the abdominal, cranial, orbital, or thoracic cavities of the embryo; or no vaccine delivery at all. In hatchery 1 (Chick Master, Newton, MS) 1,171 normal eggs were processed through the Inovoject system and 1,138 eggs were processed by the Intelliject system. The Inovoject system correctly vaccinated 94.62% of the normal eggs as compared with 61.16% delivery accuracy of normal eggs with the Intelliject system. In hatchery 2 (Jamesway Super J, Magee, MS) 926 normal eggs were processed by the Inovoject system and 910 normal eggs were processed by the Intelliject system. The Inovoject system correctly vaccinated 91.04% of the normal

  1. A Novel Framework for Agent-Based Production Remote Monitoring System Design: A Case Study of Injection Machines

    Directory of Open Access Journals (Sweden)

    Yun-Yao Chen

    2013-01-01

    Full Text Available Currently, many injection machine controllers in the market involve PC-based architecture, so engineers can conduct simple and quick operation on the controller via a human-machine interface. However, when there are too many machines in a factory, mining algorithms for multimachines and development of rear-end applications are often trivial and complicated. The operation systems of the machines in factories are different, and different machine models need different transfer protocols for data mining. Therefore, we need to develop different information platforms and machine production information mining systems for cross platform controllers. This research proposed an agent based remote monitoring system for injection machines to solve this problem. The agent-based production remote monitor system framework in this research has the following advantages. (1 It can transmit machine information cross platforms regard of constraints of different operating systems. Controlling frameworks can process data mining and transmission. (2 It can send back machine information actively to the manager without operation of machine operators, mine specific information effectively, and screen unnecessary machine information. (3 It can categorize the required information, filter extra information, and elicit data the user needs.

  2. Fabrication and characterization of injection molded multi level nano and microfluidic systems

    DEFF Research Database (Denmark)

    Matteucci, Marco; Christiansen, Thomas Lehrmann; Tanzi, Simone

    2013-01-01

    We here present a method for fabrication of multi-level all-polymer chips by means of silicon dry etching, electroplating and injection molding. This method was used for successful fabrication of microfluidic chips for applications in the fields of electrochemistry, cell trapping and DNA elongation......-treated foils and presentation of a simple model for estimating the delamination pressure. With UV surface treatments, foils of 100μm thickness were found to withstand pressures up to 9atm in Ø4mm cylindrical inlets when thermally bonded to micropatterned substrates of 2mm thickness....

  3. Pain and efficacy rating of a microprocessor-controlled metered injection system for local anaesthesia in minor hand surgery.

    Science.gov (United States)

    Nimigan, André S; Gan, Bing Siang

    2011-01-01

    Purpose. Little attention has been given to syringe design and local anaesthetic administration methods. A microprocessor-controlled anaesthetic delivery device has become available that may minimize discomfort during injection. The purpose of this study was to document the pain experience associated with the use of this system and to compare it with use of a conventional syringe. Methods. A prospective, randomized clinical trial was designed. 40 patients undergoing carpal tunnel release were block randomized according to sex into a two groups: a traditional syringe group and a microprocessor-controlled device group. The primary outcome measure was surgical pain and local anaesthetic administration pain. Secondary outcomes included volume of anaesthetic used and injection time. Results. Analysis showed that equivalent anaesthesia was achieved in the microprocessor-controlled group despite using a significantly lower volume of local anaesthetic (P = .0002). This same group, however, has significantly longer injection times (P microprocessor controlled methods of administering local anaesthetic showed similar levels of discomfort in both groups. While the microprocessor-controlled group used less volume, the total time for the administration was significantly greater.

  4. Identification of limiting case between DBA and SBDBA (CL break area sensitivity): A new model for the boron injection system

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Gonzalez, R., E-mail: r.gonzalez@ing.unipi.it [San Piero a Grado Nuclear Research Group (GRNSPG), University of Pisa, Via Livornese 1291, 56122 San Piero a Grado, Pisa (Italy); Petruzzi, A., E-mail: a.petruzzi@ing.unipi.it [San Piero a Grado Nuclear Research Group (GRNSPG), University of Pisa, Via Livornese 1291, 56122 San Piero a Grado, Pisa (Italy); D’Auria, F., E-mail: f.dauria@ing.unipi.it [San Piero a Grado Nuclear Research Group (GRNSPG), University of Pisa, Via Livornese 1291, 56122 San Piero a Grado, Pisa (Italy); Mazzantini, O., E-mail: mazzantini@na-sa.com.ar [Nucleo-electrica Argentina Sociedad Anonima (NA-SA), Buenos Aires (Argentina)

    2014-08-15

    Atucha-2 is a Siemens-designed Pressurized Heavy Water Reactor (PHWR) reactor under construction in the Republic of Argentina. Its geometrical complexity and peculiarity (e.g. oblique Control Rods, Positive Void coefficient) required a developed and validated complex three dimensional (3D) neutron kinetics (NK) coupled thermal hydraulic (TH) model. Reactor shut-down is obtained by oblique CRs and, during accidental conditions, by an emergency shut-down system (JDJ) injecting a highly concentrated boron solution (boron clouds) in the moderator tank. The boron clouds reconstruction is obtained using a Computational Fluid Dynamics (CFD) CFX code calculation. A complete Large Break Loss Of Coolant Accident (LBLOCA) calculation implies the application of the RELAP5-3D{sup ©} system code. Within the framework of the third Agreement “Nucleoelèctrica Argentina-Sociedad Anonima (NA-SA) – University of Pisa/GRNSPG” (Contract, 2009), a new RELAP5-3D control system for the boron injection system was developed and implemented in the validated coupled RELAP5-3D/NESTLE model of the Atucha 2 NPP. The aim of this activity is to find out the limiting case (maximum break area size) for the Peak Cladding Temperature for LOCAs under fixed boundary conditions.

  5. A flow injection system for the spectrophotometric determination of lead after preconcentration by solid phase extraction onto Amberlite XAD-4

    Directory of Open Access Journals (Sweden)

    Jintana Klamtet

    2008-07-01

    Full Text Available An on-line flow injection analysis (FIA system for determination of lead (II in water samples with a preconcentration step and spectrophotometric detection was investigated. The system is based on preconcentration of lead (II on a column packed with Amberlite XAD-4 resin and detection by means of 4-(2-pyridylazoresorcinol (PAR–lead complex formation with maximum absorption at 523 nm. Chemical and FIA variables influencing performance of the system were optimised. Two linear calibration curves with a range of 0.01 - 0.40 and 0.40 – 0.80 mg L-1 were obtained. The developed system allowed a throughput rate of 16 samples h-1 with a 9-fold enrichment factor and a detection limit of 7 µg L-1. Relative standard deviation for 10 replicated injections of 0.25 mg L-1 was 2.3%. Recoveries of the method were in the range of 80-94 %. The procedure was validated by analysis of lead (II in real water samples, and the results were statistically compared with those obtained by flame atomic absorption spectrophotometry (FAAS. The results obtained both by the proposed method and by FAAS were in good agreement.

  6. Sequential injection system for on-line analysis of total nitrogen with UV-mineralization.

    Science.gov (United States)

    Oms, M T; Cerdà, A; Cerdà, V

    2003-02-01

    An automatic method for the determination of total nitrogen in wastewater by sequential injection analysis and mineralization with UV radiation has been developed. The method is based on the mineralization of the samples with sodium persulphate in basic medium under UV radiation. Small volumes of sample and reagents are firstly aspirated into a single channel and then propelled by flow reversal to the UV reactor and then to the detector. The organic and inorganic nitrogen compounds are oxidized to nitrate that is then measured at 226 nm. The sequential injection procedure has been optimized and the factors affecting the efficiency of the oxidation have been studied with a number of test substances with different chemical structures and properties. Solutions in the concentration range 1-56 gl(-1) of nitrogen can be analyzed with the described procedure. The sample rate is of 30-40 samples h(-1). The LOD is 0.6 mgl(-1) N and the reproducibility is 1.8% (28 mgl(-1) N). Organic carbon in the form of glucose was added to a number of test solutions to study the potential interference of organic matter. The method was compared with the Kjeldahl digestion method by analyzing 15 wastewater samples with both methods. The nitrate and nitrite content of the non-oxidized samples were subtracted from the corresponding nitrogen content determined after photo-oxidation and the value compared with the Kjeldahl nitrogen content.

  7. Blast Furnace Granulated Coal Injection System Demonstration Project public design report. Topical report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-01

    The public design report describes the Blast Furnace Granulated Coal Injection (BFGCI) project under construction at Bethlehem Steel Corporation`s (BSC) Burns Harbor, Indiana, plant. The project is receiving cost-sharing from the U.S. Department of Energy (DOE), and is being administrated by the Morgantown Energy Technology Center in accordance with the DOE Cooperative Agreement No. DE-FC21-91MC27362. The project is the first installation in the United States for the British Steel technology using granular coal in blast furnaces. The objective is to demonstrate that granular coal is an economic and reliable fuel which can successfully be applied to large North American blast furnaces. These include: coal grind size, coal injection rate, coal source (type) and blast furnace conversion method. To achieve the program objectives, the demonstration project is divided into the following three Phases: Phase I-Design; Phase II-Procurement & Construction; and Phase III-Operation. Preliminary design (Phase I) began in 1991 with detailed design commencing in April 1993. Construction at Burns Harbor (Phase II) began August 1993. Construction is expected to be complete in the first quarter of 1995 which will be followed by a demonstration test program (Phase III).

  8. State and National Energy and Environmental Risk Analysis Systems for underground injection control. Summary annual report, April 1992--April 1993

    Energy Technology Data Exchange (ETDEWEB)

    Haas, M.R.

    1993-04-01

    ICF Resources` project, entitled {open_quotes}State and National Energy and Environmental Risk Analysis Systems for Underground Injection Control{close_quotes} includes two primary tasks (development of state and national systems respectively) and a technology transfer element. The state system was designed to assist states with data management related to underground injection control (UIC). However, during the current period, external changes (primarily pending regulatory changes at the federal level) have made the risk assessment protocol aspect of the state system of increased importance relative to data management. This protocol would assess the relative risk of groundwater contamination due to UIC activities in various areas of the state. The risk assessment system could be used to assist states in allocating scarce resources and potentially could form the analytical basis of a state variance program to respond to pending federal regulatory changes. Consequently, a substantial portion of the effort to date has been focused on this aspect of the project, The national energy and environmental risk analysis system (EERAS) is designed to enhance DOE`s analytical capabilities. This concept will be demonstrated using UIC data. The initial system design for EERAS has been completed but may be revised based on input from DOE and on the pending UIC regulatory changes. Data have been collected and organized and can be input once the file structure is finalized. The further development options for EERAS defined as part of this project will allow for the full development of the system beyond the current prototype phase which will enhance DOE`s analytical capabilities for responding to regulatory initiatives and for evaluating the benefits of risk-based regulatory approaches.

  9. Evaluation of a novel PTFE material for separation and preconcentration of trace levels of metal ions in sequential injection (SI) and sequential injection lab-on-valve (SI-LOV) systems interfaced with detection by ETAAS

    DEFF Research Database (Denmark)

    Long, Xiangbao; Chomchoei, Roongrat; Gała, Piotr

    The operational characteristics of a novel PTFE bead material, granular Algoflon®, used for separation and preconcentration of metal ions via adsorption of on-line generated non-charged metal complexes, were evaluated in a sequential injection (SI) system furnished with an external packed column...

  10. Mathematical Modeling of Fuel Pressure inside High Pressure Fuel Pipeline of Combination Electronic Unit Pump Fuel Injection System

    Directory of Open Access Journals (Sweden)

    Qaisar Hayat

    2013-08-01

    Full Text Available In order to completely understand the trend of pressure variations inside High Pressure (HP fuel pipeline of Combination Electronic Unit Pump (CEUP fuel injection system and study the impact of two major physical properties of fuel i.e., density and dynamic viscosity on pressure a 1D nonlinear dynamic mathematical model of fuel pressure inside pipeline using Wave Equation (WE has been developed in MATLAB using finite difference method. The developed model is based on the structural parameters of CEUP fuel injection system. The impact of two major physical properties of the fuel has been studied as a function of pressure at various operating conditions of diesel engine. Nearly 13.13 bars of increase in pressure is observed by increasing the density from 700 kg/m3 to 1000 kg/m3. Whereas an increase of viscosity from 2 kg/m.s to 6 kg/m.s results in decrease of pressures up to 44.16 bars. Pressure corrections in the mathematical model have been incorporated based on variations of these two fuel properties with the pressure. The resultant pressure profiles obtained from mathematical model at various distances along the pipeline are verified by correlating them with the profiles obtained from simulated AMESim numerical model of CEUP. The results show that MATLAB mathematical results are quite coherent with the AMESim simulated results and validate that the model is an effective tool for predicting pressure inside HP pipelines. The application of the this mathematical model with minute changes can therefore be extended to pressure modeling inside HP rail of Common Rail (CR fuel injection system.

  11. [Optimization of reaction conditions and methodological investigation on microtox-based fast testing system for traditional Chinese medicine injection].

    Science.gov (United States)

    Gao, Hong-Li; Li, Xiao-Rong; Yan, Liang-Chun; Zhao, Jun-Ning

    2016-05-01

    Vibrio fischeri CS234 was used to establish and optimize microtox assay system, laying a foundation for the application of this method in comprehensive acute toxicity test of traditional Chinese medicine (TCM) injections. Firstly, the Plackett-Burman method was carried out to optimize the factors which would affect Vibrio fischeri CS234 luminescence. Secondly, ZnSO4•7H2O was chosen as reference substance to establish its reaction system with quality control samples. The optimal luminescence conditions were achieved as follows: ①At a temperature of (15±1) ℃, Vibrio fischeri CS234 lyophilized powders were balanced for 15 min, then, 1 mL resuscitation fluid was added and blended for 10 min. 100 μL bacteria suspension was taken to measure the initial luminescence intensity, and then 1 mL resuscitation fluid or test sample was immediately added; after reaction for 10 min, corresponding luminescence intensity was measured again. Resuscitation diluent, osmotic pressure regulator and ZnSO4•7H2O stock solution showed no interference to the determination of Vibrio fischeri CS234 luminescence intensity, so this method was of good specificity. The within-and between-batch precisions of quality controls and the lower limit of quantification (LLOQ) samples were testing needs of the vast majority of traditional Chinese medicine injections. The Vibrio fischeri strain CS234 assay system was specific, stable, sensitive, accurate and adaptable after optimization, so it was suitable for the comprehensive acute toxicity assessment of TCM injections. Copyright© by the Chinese Pharmaceutical Association.

  12. Injection of Deuterium Pellets

    DEFF Research Database (Denmark)

    Sørensen, H.; Andersen, P.; Andersen, S. A.

    1984-01-01

    A pellet injection system made for the TFR tokamak at Fontenay-aux-Roses, Paris is described. 0.12-mg pellets are injected with velocities of around 600-700 m/s through a 5-m long guide tube. Some details of a new light gas gun are given; with this gun, hydrogen pellets are accelerated...

  13. Clinical efficacy of bone cement injectable pedicle screw system combined with intervertebral fusion in treatment of lumbar spondylolysis and osteoporosis

    Directory of Open Access Journals (Sweden)

    Peng-yi DAI

    2016-10-01

    Full Text Available Objective  To observe the therapeutic effect of bone cement injectable pedicle screw system combined with intervertebral fusion for lumbar spondylolysis and osteoporosis. Methods  The clinical data were analyzed retrospectively of 21 patients with lumbar spondylolysis and osteoporosis who received treatment of bone cement injectable pedicle screw system and intervertebral fusion from Aug. 2013 to Nov. 2015. The 21 patients (9 males and 12 females aged from 60 to 80 years (mean 64 years old; 6 of them presented degenerative spondylolysis, 15 with isthmic spondylolisthesis; 2 cases had I degree slippage, 13 had Ⅱdegree slippage, 6 had Ⅲdegree slippage, and all the cases were unisegmental slippage including 9 cases in L4 and 12 cases in L5. Bone mineral density of lumbar vertebrae (L2-L5 was measured with dual-energy X-ray absorptiometry, and T values conforming to the diagnostic criteria of osteoporosis were less than or equal to -2.5; All patients were operated with whole lamina resection for decompression, bone cement injectable pedicle screws system implantation, propped open reduction and fixation intervertebral fusion. The clinical outcomes were determined by the radiographic evaluation including intervertebral height, height of intervertebral foramen, slip distance, slip rate and slip angle, and Oswestry disability index (ODI on preoperative, 3 months after operation and the end of the time, and the interbody fusion were followed up. Results  Cerebrospinal fluid leakage of incision was observed in two cases after operation, compression and dressing to incision, Trendelenburg position, dehydration and other treatments were taken, and the stitches of incisions were taken out on schedule. Slips in the 21 patients were reset to different extent, and lumbar physiological curvatures were recovered. The intervertebral height and height of intervertebral foramen were obviously higher 3 months after operation than that before operation (P0

  14. Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system

    Institute of Scientific and Technical Information of China (English)

    José F. Ovalles; Máximo Gallignani; María R. Brunetto; Rebeca A. Rondón; Carlos Ayala

    2014-01-01

    The quantitative estimation of amikacin (AMK) in AMK sulfate injection samples is reported using FTIR-derivative spectrometric method in a continuous flow system. Fourier transform of mid-IR spectra were recorded without any sample pretreatment. A good linear calibration (r40.999, %RSDo 2.0) in the range of 7.7-77.0 mg/mL was found. The results showed a good correlation with the manufacturer's and overall they all fell within acceptable limits of most pharmacopoeial monographs on AMK sulfate.

  15. Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system

    Directory of Open Access Journals (Sweden)

    José F. Ovalles

    2014-04-01

    Full Text Available The quantitative estimation of amikacin (AMK in AMK sulfate injection samples is reported using FTIR-derivative spectrometric method in a continuous flow system. Fourier transform of mid-IR spectra were recorded without any sample pretreatment. A good linear calibration (r>0.999, %RSD<2.0 in the range of 7.7–77.0 mg/mL was found. The results showed a good correlation with the manufacturer's and overall they all fell within acceptable limits of most pharmacopoeial monographs on AMK sulfate.

  16. Kinetic enzymatic determination of glycerol in wine and beer using a sequential injection system with spectrophotometric detection.

    Science.gov (United States)

    Oliveira, Hugo M; Segundo, Marcela A; Lima, José L F C; Grassi, Viviane; Zagatto, Elias A G

    2006-06-14

    A sequential injection system for the automatic determination of glycerol in wine and beer was developed. The method is based on the rate of formation of NADH from the reaction of glycerol and NAD+ catalyzed by the enzyme glycerol dehydrogenase in solution. The determination of glycerol was performed between 0.3 and 3.0 mmol L(-1) (0.028 and 0.276 g L(-1)), and good repeatability was attained (rsd production was 2.12 mL per assay. Results obtained for samples were in agreement with those obtained with the batch enzymatic method.

  17. Biogas upgrading by injection of hydrogen in a two-stage Continuous Stirred-Tank Reactor system

    DEFF Research Database (Denmark)

    Bassani, Ilaria; Kougias, Panagiotis; Treu, Laura;

    An innovative method for biogas upgrading (i.e. CH4 content more than 90%) combines the coupling of H2, which could be produced by water electrolysis using surplus renewable electricity produced from wind mills, with the CO2 of the biogas. CO2 is biologically converted to CH4 by hydrogenotrophic...... methanogens. In this study, a novel serial biogas reactor system is presented, in which the produced biogas from the first stage reactor was introduced in the second stage, where also H2 was injected. The effects of the H2 addition on the process performance and on the microbial community were investigated...

  18. How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System

    Directory of Open Access Journals (Sweden)

    F. Castiglione

    2012-01-01

    Full Text Available The immune system is able to respond more vigorously to the second contact with a given antigen than to the first contact. Vaccination protocols generally include at least two doses, in order to obtain high antibody titers. We want to analyze the relation between the time elapsed from the first dose (priming and the second dose (boost on the antibody titers. In this paper, we couple in vivo experiments with computer simulations to assess the effect of delaying the second injection. We observe that an interval of several weeks between the prime and the boost is necessary to obtain optimal antibody responses.

  19. Construction and 60 kV tests of the prototype pulser for the LHC injection kicker system

    CERN Document Server

    Barnes, M J; Carlier, E; Ducimetière, L; Schröder, G; Vossenberg, Eugène B

    1999-01-01

    The European Laboratory for Particle Physics (CERN) is constructing the Large Hadron Collider (LHC). Two counter-rotating proton beams will be injected into the LHC at an energy of 450 GeV by two kicker magnet systems, producing magnetic field pulses of approximately 900 ns rise time and 6.6 mu s flat top duration with a ripple of less than +or-0.5Both injection systems are composed of 4 travelling wave kicker magnets of 2.17 m length each, powered by pulse forming networks (PFNs). To achieve the high-required kick strength of 1.2 Tm, for a compact and cost efficient design, a characteristic impedance of 5 Ohms has been chosen. The design strategy for the magnets and generators has been defined after detailed analysis of existing systems. The electrical circuit has been optimised using the circuit analysis software PSpice. Most known parasitics have been modelled. A prototype PFN has been constructed at CERN and successfully tested at 60 kV. A calibration procedure has been developed and utilised for obtainin...

  20. Subcutaneous Injections

    DEFF Research Database (Denmark)

    Thomsen, Maria

    This thesis is about visualization and characterization of the tissue-device interaction during subcutaneous injection. The tissue pressure build-up during subcutaneous injections was measured in humans. The insulin pen FlexTouchr (Novo Nordisk A/S) was used for the measurements and the pressure...... build-up was evaluated indirectly from the changes in the flow rate between subcutaneous injections and air injections. This method enabled the tissue counter pressure to be evaluated without a formal clinical study approval. The measurements were coupled to a model for the pressure evolution...

  1. Distribution of intravascularly injected lanthanum ions in ganglia of the autonomic nervous system of the rat.

    Science.gov (United States)

    DePace, D M

    1984-12-01

    Intravascular injection of lanthanum revealed that tight junctions of capillaries in sympathetic ganglia are impermeable to small ions and thus behave like capillaries of the blood-brain barrier. The failure of lanthanum to accumulate in the extracellular space suggests that fenestrated capillaries are not as ion-permeable as use of horseradish peroxidase (HRP) by some authors has indicated. A possible toxic action associated with high concentrations of HRP may be responsible for the high permeability of this substance. Testing with lanthanum demonstrated that sympathetic ganglia possess anatomic features that provide a hematic barrier. The blood-ganglion barrier resembles, but has not yet been demonstrated to be as absolute as the blood-brain barrier.

  2. Flow-injection chemiluminescence determination of tryptophan using galangin-potassium permanganate-polyphosphoric acid system

    Institute of Scientific and Technical Information of China (English)

    Hui Chen; Li Li; Min Zhou; Yong Jun Ma

    2008-01-01

    A high sensitive flow-injection chemiluminescence (FI-CL)method for the determination of tryptephan has been developed.The method is based on the chemiluminescence reaction of galangin-potassium perrnanganate-tryptophan in polyphosphoric acid (PPA)media.Under the optimized conditions,tryptophan was determined in the range 0.05-10 μg/mL with the detection limit (30)of 5.0× 10-3 μg/mL.The relative standard deviation (RSD)was 1.0% for 11 replicate determinations of 1.0 μg/mL tryptophan.Three synthetic samples were determined selectively with recoveries in the range from 99.6% to 102.0% in the presence of other amino acids.

  3. Role of Shenfu Injection (参附注射液) in Rats with Systemic Inflammatory Response Syndrome

    Institute of Scientific and Technical Information of China (English)

    WANG Jin; QIAO Li-fen; YANG Guang-tian

    2008-01-01

    Objective: To investigate the role of Shenfu Injection (参附注射液SFI) in rats with systemic inflammatory response syndrome (SIRS). Methods: The SIRS rat model was induced by the intravenous injection of lipopolysaccharide (LPS). Forty-five male Wistar rats were randomly divided into 3 groups, the sham operative control group (control group, n=5), the SIRS model group (model group, n=20) and the SFI treatment group (SFI group, n=20). LPS was injected through the external jugular vein (12 mg/kg, 6 mg/mL) to all rats except for those in the control group, and SFI (10 mL/kg) was given to those in the SF group only once through intraperitoneal injection, while the normal saline (10 mL/kg) was given to those in the model group. For those in the control group, normal saline was given through the external jugular vein (2 mL/kg) and intraperitoneal injection (10 mL/kg). Then, rats in the model group and SFI group were divided into 4 subgroups according to the time points, i.e., 1 h, 2 h, 4 h and 6 h subgroups, 5 rats in each group. The activity of nuclear factor of κ B(NF-κ B) of in blood mononuclear cells and the plasma levels of tumor necrosis factor-α (TNF-α) nd interleukin 6-(IL-6) were determined using enzyme-linked immunoabsordent assay (ELISA) at 1 h, 2 h, 4 h and 6 h after modeling. Histopathologic changes of the lung and liver were observed under a light microscope. Results: Compared with the control group, the activity of NF- κ B in mononuclear cells and the plasma level of TNF-α were obviously increased at each time points (all P<0.01), reaching the peaks at 2 h after modeling. The plasma level of IL-6 increased gradually as time went by in the model group (P<0.01). Pathological examination showed pulmonary alveoli hemorrhage, edema and inflammatory cell infiltration in the lung tissue, and angiotelectasis, congestion, and local necrosis in the liver tissue in the model group. Compared with the model group, the activity of NF- κ B and the levels of

  4. Efficacy of articaine and lidocaine in a primary intraligamentary injection administered with a computer-controlled local anesthetic delivery system.

    Science.gov (United States)

    Berlin, Jeffrey; Nusstein, John; Reader, Al; Beck, Mike; Weaver, Joel

    2005-03-01

    The purpose of this prospective, randomized, double-blind study was to compare the anesthetic efficacy of the intraligamentary injection of 4% articaine with 1:100,000 epinephrine and of 2% lidocaine with 1:100,000 epinephrine, administered with computer-controlled local anesthetic delivery system, in mandibular posterior teeth. Using a crossover design, intraligamentary injections of 1.4 mL of 4% articaine with 1:100,000 epinephrine and of 1.4 mL of 2% lidocaine with 1:100,000 epinephrine were randomly administered with a computer-controlled local anesthetic delivery system, in a double-blind manner on the mesial and distal aspects of a mandibular first molar, at 2 separate appointments to 51 subjects. A pulp tester was used to test for anesthesia, in 2-minute cycles for 60 minutes, of the mandibular first and second molars and second premolar. Anesthesia was considered successful when 2 consecutive 80 readings (highest output) were obtained within 20 minutes. Successful pulpal anesthesia was obtained 86% of the time for the first molar using the articaine solution and 74% of the time using the lidocaine solution. There were no significant differences (P > .05) between the articaine and lidocaine solutions. The mean onset times of pulpal anesthesia for the first molar were 1.3 minutes with articaine solution and 2.2 minutes with lidocaine solution. Duration of pulpal anesthesia for the first molar was 34 minutes for the articaine solution and 31 minutes for the lidocaine solution. The efficacy of 4% articaine with 1:100,000 epinephrine was similar to the efficacy of 2% lidocaine with 1:100,000 epinephrine for intraligamentary injections.

  5. Experimental autoimmune encephalomyelitis (EAE): lesion visualization on a 3 tesla Clinical whole-body system after intraperitoneal contrast injection

    Energy Technology Data Exchange (ETDEWEB)

    Heckl, S.; Naegele, T.; Klose, U. [Dept. of Neuroradiology, Medical School, Univ. of Tuebingen (Germany); Herrmann, M.; Gaertner, S.; Weissert, R. [Dept. of Neurology, Medical School, Univ. of Tuebingen (Germany); Schick, F. [Dept. of Radiology, Medical School, Univ. of Tuebingen (Germany); Kueker, W. [Dept. of Neuroradiology, Medical School, Univ. of Tuebingen (Germany); Dept. of Neuroradiology, Radcliffe Infirmary, Oxford, England (United Kingdom)

    2004-11-01

    Purpose: To investigate the intravital visibility of CNS lesions in rats with experimental autoimmune encephalomyelitis (EAE), the animal correlate of multiple sclerosis, using a 3-Tesla (T) wholebody MR system. Materials and Methods: Three healthy Dark Agouti (DA) rats and 16 DA rats with clinical signs of EAE were examined on a 3T whole body-system using a normal wrist coil. In total, 25 examinations were preformed using T2- and T1-weighted images in transverse and sagittal orientation with a slice thickness of 2 mm or 1 mm (voxel size up to 0.2 x 0.2 x 1 mm). Sedation was achieved by intraperitoneal injection of ketamine and xylazine. In addition, T1-weighted images were obtained after the instillation of 1.0 ml of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) (0.5 mmol/ml) into the peritoneal cavity. Results: T2- and T1-weighted images of the brain and spinal cord with high spatial and contrast resolution could be obtained in all animals. The anatomical details of the olfactory bulb glomeruli, cerebellum foliae, ventricles and corpus callosum were clearly visible. The EAE lesions presented as hyperintense area in T2-weighted images and could be demonstrated in all clinically affected animals by MRI and histologically verified. In total, the 16 affected rats had 28 cerebral and 2 spinal cord lesions (range 1 to 4, median 2). Contrast enhancement was noted in 12 animals and ranked as severe in ten and moderate in two cases. No adverse effects were noted due to sedation or intraperitoneal contrast injection. Conclusions: The intravital demonstration of cerebral and spinal cord EAE lesions in rats is possible on a 3T whole-body MR scanner using a normal wrist coil. Intraperitoneal injection of ketamine/xylazine and contrast agent is an easy, safe and effective procedure in rats. (orig.)

  6. Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9

    Directory of Open Access Journals (Sweden)

    Jonathan Dashkoff

    2016-01-01

    Full Text Available The capacity of certain adeno-associated virus (AAV vectors to cross the blood–brain barrier after intravenous delivery offers a unique opportunity for noninvasive brain delivery. However, without a well-tailored system, the use of a peripheral route injection may lead to undesirable transgene expression in nontarget cells or organs. To refine this approach, the present study characterizes the transduction profiles of new self-complementary AAV9 (scAAV9 expressing the green fluorescent protein (GFP either under an astrocyte (glial fibrillary acidic (GFA protein or neuronal (Synapsin (Syn promoter, after intravenous injection of adult mice (2 × 1013 vg/kg. ScAAV9-GFA-GFP and scAAV9-Syn-GFP robustly transduce astrocytes (11% and neurons (17%, respectively, without aberrant expression leakage. Interestingly, while the percentages of GFP-positive astrocytes with scAAV9-GFA-GFP are similar to the performances observed with scAAV9-CBA-GFP (broadly active promoter, significant higher percentages of neurons express GFP with scAAV9-Syn-GFP. GFP-positive excitatory as well as inhibitory neurons are observed, as well as motor neurons in the spinal cord. Additionally, both activated (GFAP-positive and resting astrocytes (GFAP-negative express the reporter gene after scAAV9-GFA-GFP injection. These data thoroughly characterize the gene expression specificity of AAVs fitted with neuronal and astrocyte-selective promoters after intravenous delivery, which will prove useful for central nervous system (CNS gene therapy approaches in which peripheral expression of transgene is a concern.

  7. State and national energy environmental risk analysis systems for underground injection control. Final report, April 7, 1992--May 31, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-05-01

    The purpose of this effort is to develop and demonstrate the concept of a national Energy and Environmental Risk Analysis System that could support DOE policy analysis and decision-making. That effort also includes the development and demonstration of a methodology for assessing the risks of groundwater contamination from underground injection operations. EERAS is designed to enhance DOE`s analytical capabilities by working with DOE`s existing resource analysis models for oil and gas. The full development of EERAS was not planned as part of this effort. The design and structure for the system were developed, along with interfaces that facilitate data input to DOE`s other analytical tools. The development of the database for EERAS was demonstrated with the input of data related to underground injection control, which also supported the risk assessment being performed. The utility of EERAS has been demonstrated by this effort and its continued development is recommended. Since the absolute risk of groundwater contamination due to underground injection is quite low, the risk assessment methodology focuses on the relative risk of groundwater contamination. The purpose of this methodology is to provide DOE with an enhanced understanding of the relative risks posed nationwide as input to DOE decision-making and resource allocation. Given data problems encountered, a broad assessment of all oil reservoirs in DOE`s resource database was not possible. The methodology was demonstrated using a sample of 39 reservoirs in 15 states. While data difficulties introduce substantial uncertainties, the results found are consistent with expectations and with prior analyses. Therefore the methodology for performing assessments appears to be sound. Recommendations on steps that can be taken to resolve uncertainties or obtain improved data are included in the report.

  8. Degradation of multi-DNAPLs by a UV/persulphate/ethanol system with the additional injection of a base solution.

    Science.gov (United States)

    Jung, Jae-Gu; Do, Si-Hyun; Kwon, Yong-Jae; Kong, Sung-Ho

    2015-01-01

    This study was conducted to investigate the inhibited influences on and solution to the degradation of four types of dense non-aqueous phase liquids (DNAPLs) (i.e. perchloroethylene [PCE], trichloroethylene [TCE], chloroform [CF], and carbon tetrachloride [CT]) all at the same instance in groundwater (GW). Degradations of DNAPLs in de-ionized water (DW) and GW were carried out by applying an ultraviolet radiation-activated persulphate (UV/PS) system. PCE and TCE were degraded by over 90% and CT was only degraded by 25% in both DW and GW. However, CF was degraded by over 90% in DW, while it was only degraded by 50% in GW. First of all, degradations with an inorganic anion (either Cl- or HCO3-) indicated that the lower degradation of CF in GW was caused by the existence of the chloride ion. Moreover, the low CF degradation in GW was overcome by the additional injection of a base solution (sodium hydroxide [NaOH]) into the UV/PS system. The results showed that PCE, TCE, and CF were degraded by over 90%, respectively, when a molar ratio of [base]0:[PS]0 was larger than 0.5:1, but CT was still not effectively degraded in the UV/PS system. To achieve effective CT degradation, UV/PS with the ethanol (EtOH) system was evaluated and it was found that it degraded CT over 90%. However, at this time, CF was not effectively degraded in the UV/PS/EtOH system. Finally, degradations of DNAPLs in the UV/PS/EtOH system with the additional injection of a base solution were conducted and it showed that multi-DNAPLs were degraded by over 90%, respectively, when the molar ratio of [PS]0:[EtOH]0:[base]0 was 1:1:3.

  9. Determination of trace metals in seawater by an automated flow injection ion chromatograph pretreatment system with ICPMS.

    Science.gov (United States)

    Ho, Tung-Yuan; Chien, Chia-Te; Wang, Bing-Nan; Siriraks, Archava

    2010-09-15

    A novel flow injection ion chromatograph (FI-IC) system has been developed to fully automate pretreatment procedures for multi-elemental analysis of trace metals in seawater by inductively coupled plasma mass spectrometer (ICPMS). By combining 10-port, 2 position and 3-way valves in the FI-IC manifold, the system effectively increase sample throughput by simultaneously processing three seawater samples online for: sample loading, injection, buffering, preconcentration, matrix removal, metal elution, and sample collection. Forty-two seawater samples can be continuously processed without any manual handing. Each sample pretreatment takes about 10 min by consuming 25 mL of seawater and producing 5 mL of processed concentrated samples for multi-elemental offline analysis by ICPMS. The offline analysis improve analytical precision and significantly increase total numbers of isotopes determined by ICPMS, which include the metals Al, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, Ti, V, and Zn. The blank value and detection limits of trace metals using the system with ICPMS analysis all range from 0.1 to 10 parts per trillion (ppt), except Al, Fe, and Zn. The accuracy of the pretreatment system was validated by measuring open-ocean and coastal reference seawater, NASS-5 and CASS-4. Using the system with ICPMS analysis, we have obtained reliable trace metal concentrations in the water columns of the South China Sea. Possessing the features of full automation, high throughput, low blank, and low reagent volume used, the system automates and simplifies rigorous and complicated pretreatment procedures for multi-elemental analysis of trace metals in seawater and effectively enhances analytical capacity for trace metal analysis in environmental and seawater samples.

  10. Dimethyl Ether Injection Studies

    DEFF Research Database (Denmark)

    Sorenson, Spencer C.; Glensvig, Michael; Abata, Duane L.

    1998-01-01

    effects of DME in high pressure injection have also been observed. DME has a higher compressibility than diesel fuel, resulting in larger pressure oscillations in the injection system during the injection process. The oscillations with DME also have a slower delay rate than those of diesel fuel......A series of preliminary investigations has been performed in order to investigate the behavior of DME in a diesel injection environment. These studies have in-cluded visual observations of the spray penetration and angles for high pressure injection into Nitrogen using conventional jerk pump...... in the same system. As a first attempt to simulate combustion of DME in Diesel engines, the results of the spray studies have been incorporated into a simplified spray combustion model. A turbulent jet structure was adjusted to fit the penetration rates of the observed sprays. The observed spray widths agreed...

  11. Injection MD

    CERN Document Server

    Bartmann, W; Bracco, C; Drosdal, L; Gianfelice, E; Goddard, B; Kain, V; Papaphilippou, Y; Vanbavinckhove, G

    2012-01-01

    This note summarizes the results obtained at injection during the 2nd MD block and the floating MD block in July. Highlights are presented for injection in the LHC with the Q20 SPS optics, influence of the supercycle and injection with 25 ns bunch spacing. Beams were successfully injected into the LHC using the Q20 optics [1, 3]. Small corrections were needed to steer the beam in the transfer lines. Dispersion measurements were conducted for both beams. The horizontal normalized dispersion in TI2 was a factor 2 smaller for Q20 with respect to Q26, for TI8 on the other hand the opposite was observed. The results for injection loss dependency on super cycle composition show only a small increase in losses for beam 2. The losses observed must therefore mainly come from other sources such as shot-by-shot stability or quality of scraping. For the injection with 25 ns bunch spacing bunches were injected for both beams. For B1 up to the maximum of 288 bunches. For B2 on the other only up to 144 bunches were injected...

  12. Design of Injection and Extraction Systems with Optimisation of Lattice and Layout for the CERN PS2 Synchrotron

    CERN Document Server

    Bartmann, W

    2009-01-01

    The CERN Proton Synchrotron PS2 is one of the foreseen accelerators for the LHC injector upgrade. This upgrade aims first at increasing the instantaneous luminosity of LHC and second at providing a reliable beam for the CERN accelerator complex. From this aspect, the main characteristics of the PS2 are high reliability for high intensity beams. The goal of this thesis was the design of the machine’s lattice and injection/extraction systems meeting the constraints coming mainly from the LHC beam type but also from beam requirements of experiments at PS2 and the SPS. In the design, the given energy range together with filling schemes for different beam types and RF cogging were first used to define the circumference of the machine. Estimates on the space requirements of injection/extraction systems were made in order to divide the total machine length between arc and long straight section. Existing tunnels for transfer lines together with the minimisation of the total transfer line length favoured a race trac...

  13. Monitoring Lipase/Esterase Activity by Stopped Flow in a Sequential Injection Analysis System Using p-Nitrophenyl Butyrate

    Directory of Open Access Journals (Sweden)

    Jorge Pliego

    2015-01-01

    Full Text Available Lipases and esterases are biocatalysts used at the laboratory and industrial level. To obtain the maximum yield in a bioprocess, it is important to measure key variables, such as enzymatic activity. The conventional method for monitoring hydrolytic activity is to take out a sample from the bioreactor to be analyzed off-line at the laboratory. The disadvantage of this approach is the long time required to recover the information from the process, hindering the possibility to develop control systems. New strategies to monitor lipase/esterase activity are necessary. In this context and in the first approach, we proposed a lab-made sequential injection analysis system to analyze off-line samples from shake flasks. Lipase/esterase activity was determined using p-nitrophenyl butyrate as the substrate. The sequential injection analysis allowed us to measure the hydrolytic activity from a sample without dilution in a linear range from 0.05–1.60 U/mL, with the capability to reach sample dilutions up to 1000 times, a sampling frequency of five samples/h, with a kinetic reaction of 5 min and a relative standard deviation of 8.75%. The results are promising to monitor lipase/esterase activity in real time, in which optimization and control strategies can be designed.

  14. A system for accurate and automated injection of hyperpolarized substrate with minimal dead time and scalable volumes over a large range

    Science.gov (United States)

    Reynolds, Steven; Bucur, Adriana; Port, Michael; Alizadeh, Tooba; Kazan, Samira M.; Tozer, Gillian M.; Paley, Martyn N. J.

    2014-02-01

    Over recent years hyperpolarization by dissolution dynamic nuclear polarization has become an established technique for studying metabolism in vivo in animal models. Temporal signal plots obtained from the injected metabolite and daughter products, e.g. pyruvate and lactate, can be fitted to compartmental models to estimate kinetic rate constants. Modeling and physiological parameter estimation can be made more robust by consistent and reproducible injections through automation. An injection system previously developed by us was limited in the injectable volume to between 0.6 and 2.4 ml and injection was delayed due to a required syringe filling step. An improved MR-compatible injector system has been developed that measures the pH of injected substrate, uses flow control to reduce dead volume within the injection cannula and can be operated over a larger volume range. The delay time to injection has been minimized by removing the syringe filling step by use of a peristaltic pump. For 100 μl to 10.000 ml, the volume range typically used for mice to rabbits, the average delivered volume was 97.8% of the demand volume. The standard deviation of delivered volumes was 7 μl for 100 μl and 20 μl for 10.000 ml demand volumes (mean S.D. was 9 ul in this range). In three repeat injections through a fixed 0.96 mm O.D. tube the coefficient of variation for the area under the curve was 2%. For in vivo injections of hyperpolarized pyruvate in tumor-bearing rats, signal was first detected in the input femoral vein cannula at 3-4 s post-injection trigger signal and at 9-12 s in tumor tissue. The pH of the injected pyruvate was 7.1 ± 0.3 (mean ± S.D., n = 10). For small injection volumes, e.g. less than 100 μl, the internal diameter of the tubing contained within the peristaltic pump could be reduced to improve accuracy. Larger injection volumes are limited only by the size of the receiving vessel connected to the pump.

  15. A system for accurate and automated injection of hyperpolarized substrate with minimal dead time and scalable volumes over a large range☆

    Science.gov (United States)

    Reynolds, Steven; Bucur, Adriana; Port, Michael; Alizadeh, Tooba; Kazan, Samira M.; Tozer, Gillian M.; Paley, Martyn N.J.

    2014-01-01

    Over recent years hyperpolarization by dissolution dynamic nuclear polarization has become an established technique for studying metabolism in vivo in animal models. Temporal signal plots obtained from the injected metabolite and daughter products, e.g. pyruvate and lactate, can be fitted to compartmental models to estimate kinetic rate constants. Modeling and physiological parameter estimation can be made more robust by consistent and reproducible injections through automation. An injection system previously developed by us was limited in the injectable volume to between 0.6 and 2.4 ml and injection was delayed due to a required syringe filling step. An improved MR-compatible injector system has been developed that measures the pH of injected substrate, uses flow control to reduce dead volume within the injection cannula and can be operated over a larger volume range. The delay time to injection has been minimized by removing the syringe filling step by use of a peristaltic pump. For 100 μl to 10.000 ml, the volume range typically used for mice to rabbits, the average delivered volume was 97.8% of the demand volume. The standard deviation of delivered volumes was 7 μl for 100 μl and 20 μl for 10.000 ml demand volumes (mean S.D. was 9 ul in this range). In three repeat injections through a fixed 0.96 mm O.D. tube the coefficient of variation for the area under the curve was 2%. For in vivo injections of hyperpolarized pyruvate in tumor-bearing rats, signal was first detected in the input femoral vein cannula at 3–4 s post-injection trigger signal and at 9–12 s in tumor tissue. The pH of the injected pyruvate was 7.1 ± 0.3 (mean ± S.D., n = 10). For small injection volumes, e.g. less than 100 μl, the internal diameter of the tubing contained within the peristaltic pump could be reduced to improve accuracy. Larger injection volumes are limited only by the size of the receiving vessel connected to the pump. PMID:24355621

  16. Subcutaneous Injections

    DEFF Research Database (Denmark)

    Thomsen, Maria

    This thesis is about visualization and characterization of the tissue-device interaction during subcutaneous injection. The tissue pressure build-up during subcutaneous injections was measured in humans. The insulin pen FlexTouchr (Novo Nordisk A/S) was used for the measurements and the pressure...... build-up was evaluated indirectly from the changes in the flow rate between subcutaneous injections and air injections. This method enabled the tissue counter pressure to be evaluated without a formal clinical study approval. The measurements were coupled to a model for the pressure evolution...... in subcutaneous tissue, based on mass conservation and flow in a porous medium. From the measurements the flow permeability and bulk modulus of the tissue were determined. In the adipose tissue the drug forms a bolus from where it is absorbed by the blood capillaries. The spatial distribution of the injected...

  17. The efficiency of intratympanic dexamethasone injection as a sequential treatment after initial systemic steroid therapy for sudden sensorineural hearing loss.

    Science.gov (United States)

    Lee, Jong Bin; Choi, Seong Jun; Park, Keehyun; Park, Hun Yi; Choo, Oak-Sung; Choung, Yun-Hoon

    2011-06-01

    The effect of intratympanic steroid injection is controversial as salvage or initial treatment option for sudden sensorineural hearing loss (SSNHL) and almost unknown if it is consecutively to use after initial systemic steroids. This study aimed to analyze the efficiency of intratympanic dexamethasone injection (ITDI) as a sequential treatment in the patients who failed initial systemic steroid treatments for SSNHL. Forty-six patients with SSNHL who did not respond to initial systemic steroids were prospectively included in the study. The patients were randomly classified into two groups; the ITDI group (21 patients) did not take four sequential ITDI within 2 weeks after systemic steroids, and the control group (25 patients) took any more medications. Hearing improvement was defined as a 10 dB or more decrease in the pure tone average (PTA) of the four-frequencies (0.5, 1, 2, and 3 kHz). Hearing improvement was observed in 10 (47.6%) of 21 ITDI patients and in 4 (16.0%) of 25 control patients (P = 0.027). An improvement of the mean PTA was 11.4 dB in the ITDI group and 1.7 dB in the control group (P = 0.004). The ITDI group showed significant hearing improvement at low frequency (500 Hz) than the control group. The patients with 70 or more dB in PTA before ITDI showed significant hearing improvement than the other patients with better PTAs (P = 0.038). The sequential ITDI, which is performed immediately after initial systemic steroid therapy, may be a simple, effective second-line treatment of choice for the patients who show poor response to initial treatments for SSNHL.

  18. Flow injection-chemiluminescence determination of ascorbic acid based on luminol–ferricyanide–gold nanoparticles system

    Energy Technology Data Exchange (ETDEWEB)

    Dong, Yong Ping, E-mail: dongyp@ahut.edu.cn [School of chemistry and chemical engineering, Anhui University of Technology, Maanshan, China, 243002 (China); Gao, Ting Ting; Chu, Xiang Feng; Chen, Jun [School of chemistry and chemical engineering, Anhui University of Technology, Maanshan, China, 243002 (China); Wang, Cheng Ming, E-mail: chmwang@ustc.edu.cn [Hefei National Laboratory for Physical Science at the Microscale, University of Science and Technology of China, Hefei, China, 230026 (China)

    2014-10-15

    A novel flow-injection chemiluminescence (CL) method for the determination of ascorbic acid (AA) is proposed, based upon its enhancing effect on the CL reaction of luminol with ferricyanide catalyzed by gold nanoparticles in alkaline solution. Different sizes gold nanoparticles exhibited different catalyzing effect towards luminol CL and 38 nm gold nanoparticles exhibited the best enhancing effect. Under the optimal experimental conditions, a linear relationship was obtained between the CL intensity and the concentration of ascorbic acid in the range of 1.0×10{sup −10}–1.0×10{sup −6} mol L{sup −1}. The detection limit was 2.0×10{sup –11} mol {sup −1} and the relative standard deviation for 1.0×10{sup −6} mol L{sup −1} ascorbic acid was 0.71% (n=10). This method has been successfully applied in the determination of ascorbic acid in several real samples. - Highlights: • Gold nanoparticles could enhance luminol–K{sub 3}Fe(CN){sub 6} CL signal. • 38 nm gold nanoparticles exhibited the best catalyzing effect. • Ascorbic acid could further enhance luminol–K{sub 3}Fe(CN){sub 6}–gold nanoparticles CL. • Ascorbic acid could be detected sensitively based on its enhancing effect.

  19. A sequential injection system for the spectrophotometric determination of calcium, magnesium and alkalinity in water samples.

    Science.gov (United States)

    Mesquita, Raquel B R; Rangel, António O S S

    2004-08-01

    A sequential injection methodology for the spectrophotometric determination of calcium, magnesium and alkalinity in water samples is proposed. A single manifold is used for the determination of the three analytes, and the same protocol sequence allows the sequential determination of calcium and magnesium (the sum corresponds to the water hardness). The determination of both metals is based on their reaction with cresolphtalein complexone; mutual interference is minimized by using 8-hydroxyquinoline for the determination of calcium and ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA) for the determination of magnesium. Alkalinity determination is based on a reaction with acetic acid, and corresponding color change of Bromcresol Green. Working ranges of 0.5 - 5 mg dm(-3) for Ca, 0.5 - 10 mg dm(-3) for Mg, and 10 - 100 mg HCO3- dm(-3), for alkalinity have been achieved. The results for water samples were comparable to those of the reference methods and to a certified reference water sample. RSDs lower than 5% were obtained, a low reagent consumption and a reduced volume of effluent have been accomplished. The determination rate for calcium and magnesium is 80 h(-1), corresponding to 40 h(-1) per element, while 65 determinations of alkalinity per hour could be carried out.

  20. The evaluation of physical properties of injection molded systems based on poly(ethylene oxide) (PEO).

    Science.gov (United States)

    Pajander, Jari; Rensonnet, Alexia; Hietala, Sami; Rantanen, Jukka; Baldursdottir, Stefania

    2017-02-25

    The effect of product design parameters on the formation and properties of an injection molded solid dosage form consisting of poly(ethylene oxide)s (PEO) and two different active pharmaceutical ingredients (APIs) was studied. The product design parameters explored were melting temperature and the duration of melting, API loading degree and the molecular weight (Mw) of PEO. The solid form composition of the model APIs, theophylline and carbamazepine, was of specific interest, and its possible impact on the in vitro drug release behavior. Mw of PEO had the greatest impact on the release rate of both APIs. High Mw resulted in slower API release rate. Process temperature had two-fold effect with PEO 300,000g/mol. Firstly, higher process temperature transformed the crystalline part of the polymer into metastable folded form (more folded crystalline regions) and less into the more stable extended form (more extended crystalline regions), which lead to enhanced theophylline release rate. Secondly, the higher process temperature seemed to induce carbamazepine polymorphic transformation from p-monoclinic form III (carbamazepine (M)) into trigonal form II (carbamazepine (T)). The results indicated that the actual content of carbamazepine (T) affected drug release behavior more than the magnitude of transformation.

  1. Screening and determination of sulphonamide residues in bovine milk samples using a flow injection system.

    Science.gov (United States)

    Fernandes, Flávio Cesar Bedatty; Silva, Aline Santana; Rufino, José Luiz; Pezza, Helena Redigolo; Pezza, Leonardo

    2015-01-01

    A new, simple, rapid and sensitive flow injection spectrophotometric method was developed for the screening and determination of sulphonamides in bovine milk samples. The method is based on the condensation of sulphathiazole, sulphamethazine, and sulphadimethoxine with p-dimethylaminobenzaldehyde (p-DAB) in acid medium, in the presence of sodium dodecyl sulphate (SDS), producing a yellow compound (λmax=465 nm). Optimisation of the experimental parameters was performed using a multivariate methodology. The linear range was 90-500 μg/L and the limits of detection and quantification were in the ranges 25-29 μg/L and 84-88 μg/L, respectively. The procedure was applied for the determination of sulphonamide antibiotics in bovine milk samples submitted to a prior extraction procedure based on QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) methodology. Recoveries of 60.5-70.5% were achieved for milk samples spiked with 0.09, 0.1, 0.2, and 0.3 μg/g of each sulphonamide.

  2. Mixing in a three-phase system: Enhanced production of oil-wet reservoirs by CO2 injection

    Science.gov (United States)

    Jiménez-Martínez, Joaquín.; Porter, Mark L.; Hyman, Jeffrey D.; Carey, J. William; Viswanathan, Hari S.

    2016-01-01

    We recreate three-phase reservoir conditions (high-pressure/temperature) using a microfluidics system and show that the use of scCO2 for restimulation operations, such as hydraulic fracturing, can enhance mixing and production. The results inform hydrocarbon extraction from deep shale formations, which has recently generated an energy boom that has lowered hydrocarbon costs. However, production decreases rapidly and methods to increase efficiency or allow restimulation of wells are needed. In our experiments, the presence of residual brine from initial production creates spatiotemporal variability in the system that causes the injected scCO2 to more effectively interact-mix with trapped hydrocarbon, thereby increasing recovery. We apply volume-averaging techniques to upscale brine saturation, which allows us to analyze the complex three-phase system in the framework of well characterized two-phase systems. The upscaled three-phase system behaves like a two-phase system: greater mixing with larger non-wetting content and higher heterogeneity. The results are contrary to previous observations in water-wet systems.

  3. Electrokinetic gated injection-based microfluidic system for quantitative analysis of hydrogen peroxide in individual HepG2 cells.

    Science.gov (United States)

    Zhang, Xinyuan; Li, Qingling; Chen, Zhenzhen; Li, Hongmin; Xu, Kehua; Zhang, Lisheng; Tang, Bo

    2011-03-21

    A microfluidic system to determine hydrogen peroxide (H(2)O(2)) in individual HepG2 cells based on the electrokinetic gated injection was developed for the first time. A home-synthesized fluorescent probe, bis(p-methylbenzenesulfonate)dichlorofluorescein (FS), was employed to label intracellular H(2)O(2) in the intact cells. On a simple cross microchip, multiple single-cell operations, including single cell injection, cytolysis, electrophoresis separation and detection of H(2)O(2), were automatically carried out within 60 s using the electrokinetic gated injection and laser-induced fluorescence detection (LIFD). The performance of the method was evaluated under the optimal conditions. The linear calibration curve was over a range of 4.39-610 amol (R(2)=0.9994). The detection limit was 0.55 amol or 9.0×10(-10) M (S/N=3). The relative standard deviations (RSDs, n=6) of migration time and peak area were 1.4% and 4.8%, respectively. With the use of this method, the average content of H(2)O(2) in single HepG2 cells was found to be 16.09±9.84 amol (n=15). Separation efficiencies in excess of 17,000 theoretical plates for the cells were achieved. These results demonstrated that the efficient integration and automation of these single-cell operations enabled the sensitive, reproducible, and quantitative examination of intracellular H(2)O(2) at single-cell level. Owing to the advantages of simple microchip structure, controllable single-cell manipulation and ease in building, this platform provides a universal way to automatically determine other intracellular constituents within single cells.

  4. High conversion self-curing sealer based on a novel injectable polyurethane system for root canal filling

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Bin [Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064 (China); Zuo, Yi, E-mail: zoae@scu.edu.cn [Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064 (China); Li, Jidong; Wang, Li [Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064 (China); Tang, Kuangyun [The State Key Laboratory of Oral Diseases and Orthognathic Surgery, Sichuan University West China College of Stomatology, Chengdu 610064 (China); Huang, Di; Du, Jingjing; Luo, Peipei; Li, Yubao [Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064 (China)

    2013-08-01

    Low monomer–polymer conversion is the key factor leading to cytotoxicity for resin-containing restorative materials. This paper provides a new root canal filling system based on self-curing injectable polyurethane which can achieve high conversion in a short time. Traced FTIR spectra show more than 90% NCO group participated in the curing reaction after 4 h, and only about 5% remained after 24 h. The calculated data also testified the curing process supports a third-order reaction, and this efficient and sufficient reaction is postulated to weaken the toxic stimulation. By culturing with L929 murine fibroblasts, the PU sealer is shown to be favorable for cell attachment and proliferation. Then physicochemical properties of the injectable PU-based sealer were evaluated according to the Standard [ISO 6876:2001 (E)] for clinical application. A series of physicochemical properties of PU sealer have been tested comparing with AH Plus and Apexit Plus. And the results present that the self-curing PU sealer could not only match the clinic requirements, but even has better properties than the other two commercial sealers. We expect the high conversion PU sealer has a tremendous potential in the field of root canal filling after further biological evaluation. - Highlights: • A new root canal sealer based on self-curing injectable polyurethane was provided. • More than 90% NCO group reacted after 4h, and only about 5% remained after 24 h. • By culturing with L929 murine fibroblasts, the PU sealer showed perfect cytocompatibility. • Volumetric dilatancy after curing will make the sealer achieve a tight seal.

  5. Automated resolution of dichlorvos and methylparaoxon pesticide mixtures employing a Flow Injection system with an inhibition electronic tongue.

    Science.gov (United States)

    Valdés-Ramírez, G; Gutiérrez, M; Del Valle, M; Ramírez-Silva, M T; Fournier, D; Marty, J-L

    2009-01-01

    An amperometric biosensor array has been developed to resolve pesticide mixtures of dichlorvos and methylparaoxon. The biosensor array has been used in a Flow Injection system, in order to operate automatically the inhibition procedure. The sensors used were three screen-printed amperometric biosensors that incorporated three different acetylcholinesterase enzymes: the wild type from Electric eel and two different genetically modified enzymes, B1 and B394 mutants, from Drosophila melanogaster. The inhibition response triplet was modelled using an Artificial Neural Network which was trained with mixture solutions that contain dichlorvos from 10(-4) to 0.1 microM and methylparaoxon from 0.001 to 2.5 microM. This system can be considered an inhibition electronic tongue.

  6. Negative cooperative effect of cytotoxicity of a di-component initiating system for a novel injectable tissue engineering hydrogel

    Institute of Scientific and Technical Information of China (English)

    DUAN Shifeng; ZHU Wen; YU Lin; DING Jiandong

    2005-01-01

    Chemically cross-linked hydrogels constitute a novel injectable tissue engineering material. At present, one of the key problems is to find an appropriate initiator. This study evaluated the cytotoxicity in vitro of a water-soluble redox initiating system consisting of ammonium persulfate (APS) and N, N, N′, N′-tetramethylethylenediamine (TEM- ED). Gelation time of PEG diacrylate macromer in phosphate buffer saline solution was first adjusted to guarantee that the examined initiator concentrations are sufficiently high to trigger polymerization of macromers. NIH/3T3 fibroblasts were employed to examine cytotoxicity via MTT measurements and optical microscopic observations. It has been found that the combined APS/TEMED system exhibits negative cooperative effect, for the underlying cytotoxicity is even lower than that of APS or TEMED at certain concentrations.

  7. Determination of free and total sulfites in wine using an automatic flow injection analysis system with voltammetric detection.

    Science.gov (United States)

    Goncalves, Luis Moreira; Grosso Pacheco, Joao; Jorge Magalhaes, Paulo; Antonio Rodrigues, Jose; Araujo Barros, Aquiles

    2010-02-01

    An automated flow injection analysis (FIA) system, based on an initial analyte separation by gas-diffusion and subsequent determination by square-wave voltammetry (SWV) in a flow cell, was developed for the determination of total and free sulfur dioxide (SO(2)) in wine. The proposed method was compared with two iodometric methodologies (the Ripper method and a simplified method commonly used by the wine industry). The developed method displayed good repeatability (RSD lower than 6%) and linearity (between 10 and 250 mg l(-1)) as well as a suitable LOD (3 mg l(-1)) and LOQ (9 mg l(-1)). A major advantage of this system is that SO(2) is directly detected by flow SWV.

  8. X-tip intraosseous injection system as a primary anesthesia for irreversible pulpitis of posterior mandibular teeth: A randomized clinical trail.

    Science.gov (United States)

    Razavian, Hamid; Kazemi, Shantia; Khazaei, Saber; Jahromi, Maryam Zare

    2013-03-01

    Successful anesthesia during root canal therapy may be difficult to obtain. Intraosseous injection significantly improves anesthesia's success as a supplemental pulpal anesthesia, particularly in cases of irreversible pulpitis. The aim of this study was to compare the efficacy of X-tip intraosseous injection and inferior alveolar nerve (IAN) block in primary anesthesia for mandibular posterior teeth with irreversible pulpitis. Forty emergency patients with an irreversible pulpitis of mandibular posterior teeth were randomly assigned to receive either intraosseous injection using the X-tip intraosseous injection system or IAN block as the primary injection method for pulpal anesthesia. Pulpal anesthesia was evaluated using an electric pulp tester and endo ice at 5-min intervals for 15 min. Anesthesia's success or failure rates were recorded and analyzed using SPSS version 12 statistical software. Success or failure rates were compared using a Fisher's exact test, and the time duration for the onset of anesthesia was compared using Mann-Whitney U test. P < 0.05 was considered significant. Intraosseous injection system resulted in successful anesthesia in 17 out of 20 patients (85%). Successful anesthesia was achieved with the IAN block in 14 out of 20 patients (70%). However, the difference (15%) was not statistically significant (P = 0.2). Considering the relatively expensive armamentarium, probability of penetrator separation, temporary tachycardia, and possibility of damage to root during drilling, the authors do not suggest intraosseous injection as a suitable primary technique.

  9. X-tip intraosseous injection system as a primary anesthesia for irreversible pulpitis of posterior mandibular teeth: A randomized clinical trail

    Directory of Open Access Journals (Sweden)

    Hamid Razavian

    2013-01-01

    Full Text Available Background: Successful anesthesia during root canal therapy may be difficult to obtain. Intraosseous injection significantly improves anesthesia′s success as a supplemental pulpal anesthesia, particularly in cases of irreversible pulpitis. The aim of this study was to compare the efficacy of X-tip intraosseous injection and inferior alveolar nerve (IAN block in primary anesthesia for mandibular posterior teeth with irreversible pulpitis. Materials and Methods: Forty emergency patients with an irreversible pulpitis of mandibular posterior teeth were randomly assigned to receive either intraosseous injection using the X-tip intraosseous injection system or IAN block as the primary injection method for pulpal anesthesia. Pulpal anesthesia was evaluated using an electric pulp tester and endo ice at 5-min intervals for 15 min. Anesthesia′s success or failure rates were recorded and analyzed using SPSS version 12 statistical software. Success or failure rates were compared using a Fisher′s exact test, and the time duration for the onset of anesthesia was compared using Mann-Whitney U test. P < 0.05 was considered significant. Results: Intraosseous injection system resulted in successful anesthesia in 17 out of 20 patients (85%. Successful anesthesia was achieved with the IAN block in 14 out of 20 patients (70%. However, the difference (15% was not statistically significant ( P = 0.2. Conclusion: Considering the relatively expensive armamentarium, probability of penetrator separation, temporary tachycardia, and possibility of damage to root during drilling, the authors do not suggest intraosseous injection as a suitable primary technique.

  10. Fluoroscopy-guided intra-articular steroid injection for sternoclavicular joint arthritis secondary to limited cutaneous systemic sclerosis: a case report

    Science.gov (United States)

    Güler, Emel; Cüce, Isa; Erol, Kemal

    2017-01-01

    We report a case of fluoroscopy-guided intraarticular steroid injection for sternoclavicular joint (SCJ) arthritis caused by limited cutaneous systemic sclerosis (SSc). A 50-year-old woman diagnosed with limited cutaneous SSc presented with swelling and pain in the right SCJ. MRI revealed signs of inflammation consistent with right-sided sternoclavicular joint arthritis. After the failure of oral medications, we performed fluoroscopy-guided injection in this region. She reported complete resolution of her symptoms at 4 and 12-week follow-ups. This outcome suggests that a fluoroscopy-guided SCJ injection might be a safe and successful treatment option for sternoclavicular joint arthritis. PMID:28119772

  11. Control by damping Injection of Electrodynamic Tether System in an Inclined Orbit

    DEFF Research Database (Denmark)

    Larsen, Martin Birkelund; Blanke, Mogens

    2009-01-01

    Control of a satellite system with an electrodynamic tether as actuator is a time-periodic and underactuated control problem. This paper considers the tethered satellite in a Hamiltonian framework and determines a port-controlled Hamiltonian formulation that adequately describes the nonlinear...... dynamical system. Based on this model, a nonlinear controller is designed that will make the system asymptotically stable around its open-loop equilibrium. The control scheme handles the time-varying nature of the system in a suitable manner resulting in a large operational region. The performance...

  12. Systems interaction results from the digraph matrix analysis of the Watts Bar Nuclear Power Plant high pressure safety injection systems. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Sacks, I.J.; Ashmore, B.C.; Alesso, H.P.

    1983-07-01

    Spatial and functional coupling (including human actions) of nuclear power plant systems that lead to interdependencies are called Systems Interactions. At present, the US Nuclear Regulatory Commission (NRC) is investigating ways of integrating a systems interactions study with existing Probabilistic Risk Assessment efforts. One approach is based on graph-theoretic methods utilizing matrix representations of logic diagrams called Digraph Matrix Analysis (DMA). The objective in this report is to demonstrate the capabilities of Digraph Matrix Analysis to model an accident sequence (including front-line systems, support systems and human actions) as a continuous, well-integrated logic model in order to identify and evaluate functional systems interactions. The selected accident sequence, loss of high pressure safety injection during a LOCA, was modeled and qualitative and quantitative comparisons were made to the Reactor Safety Study (WASH 1400) and other studies.

  13. Systems interaction results from the digraph matrix analysis of the Watts Bar Nuclear Power Plant high pressure safety injection systems. Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Sacks, I.J.; Ashmore, B.C.; Alesso, H.P.

    1983-07-01

    Spatial and functional coupling of nuclear power plant systems that lead to interdependencies are called Systems Interactions. At present, the US Nuclear Regulatory Commission (NRC) is investigating ways of integrating a systems interactions study with existing Probabilistic Risk Assessment efforts. One approach is based on graph-theoretic methods utilizing matrix representations of logic diagrams called Digraph Matrix Analysis (DMA). The objective in this report is to demonstrate the capabilities of Digraph Matrix Analysis to model an accident sequence (including front line systems, support systems and human actions) as a continuous, well-integrated logic model in order to identify and evaluate functional systems interactions. The selected accident sequence, loss of high pressure safety injection during an S1 LOCA, was modeled and qualitative and quantitative comparisons were made to WASH 1400 aand other studies.

  14. Influencing Mechanism of Opening Pressure on Fuel Injection Quantity of Electronic Unit Pump Injection System%启喷压力对电控单体泵供油系统喷油量的影响机理

    Institute of Scientific and Technical Information of China (English)

    严明; 杨青; 王沛; 刘福水

    2015-01-01

    以电控单体泵燃油系统为研究对象,研究了启喷压力对循环喷油量的影响。通过计算各工况下循环喷油量随启喷压力变化的百分比,研究了各工况循环喷油量随启喷压力变化的敏感程度,在此基础上进行了启喷压力对循环喷油量影响的机理分析。结果表明:循环喷油量随启喷压力的增加呈减小趋势,随着转速的增加,启喷压力对循环喷油量的影响程度越来越小;在各确定转速下,随着喷油脉宽的增加,循环喷油量对启喷压力变化的敏感程度越来越低;低速时启喷压力主要通过影响喷油器针阀开启关闭的运动过程而影响循环喷油量,中高速时启喷压力主要通过影响有效喷油脉宽而影响循环喷油量。%For the electronic unit pump (EUP) fuel system ,the influence of opening pressure on fuel injection quantity per cy‐cle was researched .The sensitivity of fuel injection quantity to opening pressure was revealed by calculating the changed per‐centage of fuel injection quantity per cycle to opening pressure and the influencing mechanism of opening pressure on fuel injec‐tion quantity per cycle was researched .The results show that the fuel injection quantity decreases with the increase of opening pressure and is less influenced by the opening pressure with the increase of speed .At each certain speed ,the sensitivity of fuel injection quantity per cycle to opening pressure becomes weaker with the increase of injection pulse width .The fuel injection quantity per cycle is influenced by the opening and closing movement of injector needle valve at low speed and is influenced by the change of effective injection pulse width at medium and high speed .

  15. In situ staining of the primo vascular system in the ventricles and subarachnoid space of the brain by trypan blue injection into the lateral ventricle

    Institute of Scientific and Technical Information of China (English)

    Jingxing Dai; Byung-Cheon Lee; Ping An; Zhendong Su; Rongmei Qu; Ki Hoon Eom; Kwang-Sup Soh

    2011-01-01

    We examined a new method for visualization of the primo vascular system in the rat brain in-volving lateral ventricle injection of trypan blue. Results showed that the primo vascular system in the lateral ventricles and arachnoid mater of the brain were preferentially stained relative to blood vessels and fascia. The primo-vessels along blood vessels in the brain were clearly ex-hibited. In addition, the primo vascular system was evident between the fourth ventricle and the quadrigeminal cistern. Our experimental findings indicate that this new technique of lateral ventricle injection of trypan blue can visualize the primo vascular system in lateral ventricles and arachnoid mater of rats in situ.

  16. Controllable Photovoltaic Grid Power Injection with an Assistance of Energy Storage System

    DEFF Research Database (Denmark)

    Morvaj, Boran; Dragicevic, Tomislav; Krajcar, Slavko

    2013-01-01

    This paper focuses on modeling and simulation of controllable Photovoltaic Battery Power System (PV BPS) interconnected to the electrical utility. After elaboration of modeling principles for different components appearing in the system, simulations of two types of PV plants connected to one branch...

  17. FLOW INJECTION ANALYSIS SYSTEM COUPLED WITH ICP-EOS FOR DETERMINATION OF SOME METALLIC ELEMENTS IN DRINKING WATER

    Directory of Open Access Journals (Sweden)

    Cristina Dinu

    2009-06-01

    Full Text Available The European Drinking Water Directive (98/83/EC, transposed in Romanian Legislation as Low 458/2002, amended by Low 311/2004, imposes the limit of concentration for metallic elements in water intended for human consumption. The toxic metals arsenic and selenium are among these elements and the limit value is 10 μg/L. In the paper there are presented the working conditions for determination of As and Se from drinking water using modern techniques based on the fl ow injection-hydride generation with the inductively coupled plasma atomic emission spectrometry (FIAS-ICP-EOS. The analyses were performed on Optima 5300 DV Perkin Elmer equipment with FIAS 400 Flow Injection System, Perkin Elmer type. For the hydride generation two types of solution were used: 10% (v/v HCl as a carrier solution and 0.2 % NaBH4 in 0.05%NaOH solution as a reducing agent [1]. The treatment step of the samples and standard solutions consisted in reducing with mixed solutions of KI and ascorbic acid in acidic condition (HCl for As and only with HCl and high temperature for Se [2,3]. The paper contains the characteristic parameters of the methods, such as: low detection limit, quantifi cation limit, repeatability, precision, recovery, which were evaluated using Certifi ed Reference Materials for each element.

  18. Multi-point injection: A general purpose delivery system for treatment and containment of hazardous and radiological waste

    Energy Technology Data Exchange (ETDEWEB)

    Kauschinger, J.L. [Ground Environmental Services, Alpharetta, GA (United States); Kubarewicz, J. [Jacobs Engineering, Oak Ridge, TN (United States); Van Hoesen, S.D. [Lockheed Martin Energy Systems, Oak Ridge, TN (United States)

    1997-12-31

    The multi-point injection (MPI) technology is a proprietary jetting process for the in situ delivery of various agents to treat radiological and/or chemical wastes. A wide variety of waste forms can be treated, varying from heterogeneous solid waste dumped into shallow burial trenches, bottom sludge (heel material) inside of underground tanks, and contaminated soils with widely varying soil composition (gravel, silts/clays, soft rock). The robustness of the MPI system is linked to the use of high speed mono-directional jets to deliver various types of agents for a variety of applications, such as: pretreatment of waste prior to insitu vitrification, solidification of waste for creating low conductivity monoliths, oxidants for insitu destruction of organic waste, and grouts for creating barriers (vertical, inclined, and bottom seals). The only strict limitation placed upon the MPI process is that the material can be pumped under high pressure. This paper describes the procedures to inject ordinary grout to form solidified monoliths of solid wastes.

  19. Effect of Dopamine Injection on the Hemocyte Count and Prophenoloxidase System of the White Shrimp Litopenaeus vannamei

    Institute of Scientific and Technical Information of China (English)

    PAN Luqing; HU Fawen; ZHENG Debin

    2011-01-01

    Effects of dopamine injection on the hemocyte count,phenoloxidase activity,serine proteinase activity,proteinase inhibitor activity and α2-macroglobulin-like activity in L.vannamei were studied.Results showed that dopamine injection resulted in a significant effect on the parameters measured (P<0.05),while no significant difference was observed in the control group (0.85% NaCl).In the experimental groups,the hemocyte count reached the minimum in 3 h; granular and semi-granular cells became stable after 12 h and hyaline cells and the total hemocyte count became stable after 18 h.Phenoloxidase activity reached the minimum in 6 h,and then became stable after 9h.Serine protease activity and proteinase inhibitor activity reached the minimum in 3 h,and α2-macroglobulin-like activity reached the maximum in 3 h,and all the three parameters became stable after 12 h.The results suggest that the activating mechanisms of the proPO system triggered by dopamine are different from those triggered by invasive agents or spontaneously activated under a normal physical condition.

  20. Performance and combustion analysis of Mahua biodiesel on a single cylinder compression ignition engine using electronic fuel injection system

    Directory of Open Access Journals (Sweden)

    Gunasekaran Anandkumar

    2016-01-01

    Full Text Available In this investigation, experiment is carried out on a 1500 rpm constant speed single cylinder Diesel engine. The test is carried out with Neat diesel, neat biodiesel, and blend B20. The engine considered was run with electronic fuel injection system supported by common rail direct injection to obtain high atomization and effective air utilization inside the combustion chamber. The performance of the engine in terms of break thermal efficiency and brake specific energy consumption was found and compared. The B20 blend shows 1.11% decrease in break thermal efficiency and 3.35% increase in brake specific energy consumption than diesel. The combustion characteristics found are in-cylinder pressure, rate of pressure rise, and heat release rate and compared for peak pressure load to understand the nature of combustion process. For each fuel test run, the maximum peak pressure is observed at part load condition. The rate of change of pressure and heat release rate of diesel is high compared to pure biodiesel and B20 blend. The diffusion combustion is observed to be predominant in case of B100 than B20 and Neat diesel.

  1. Injectable in situ forming drug delivery system for cancer chemotherapy using a novel tissue adhesive: characterization and in vitro evaluation.

    Science.gov (United States)

    Kakinoki, Sachiro; Taguchi, Tetsushi; Saito, Hirofumi; Tanaka, Junzo; Tateishi, Tetsuya

    2007-06-01

    Injectable polymers that are biocompatible and biodegradable are important biomaterials for drug delivery system (DDS) and tissue engineering. We have already developed novel tissue adhesives consisting of biomacromolecules and organic acid derivatives with active ester groups. The resulting tissue adhesive forms in situ as a gel and has high bonding strength for living tissue as well as it has good biocompatibility and biodegradability. Here, we report on the physicochemical properties and in vitro evaluation of this novel tissue adhesive consisting of human serum albumin (HSA) and tartaric acid derivative (TAD) containing doxorubicin hydrochloride (DOX). The results of the measurement of physicochemical characteristics indicate that the gelation time and gel strength of HSA-TAD gels can be controlled according to the material composition. The bonding strength of HSA-TAD adhesives was found to be sufficient to adhere at focus and to correspond with the cross-linking density of HSA-TAD gels. Furthermore, the release of DOX from HSA-TAD gels was sustained for approximately 100 h in an in vitro evaluation. The novel tissue adhesive, therefore, is expected to be applicable for use as an injectable in situ forming DDS.

  2. Delivery of interleukin-10 via injectable hydrogels improves renal outcomes and reduces systemic inflammation following ischemic acute kidney injury in mice.

    Science.gov (United States)

    Soranno, Danielle E; Rodell, Christopher B; Altmann, Christopher; Duplantis, Jane; Andres-Hernando, Ana; Burdick, Jason A; Faubel, Sarah

    2016-08-01

    Injectable hydrogels can be used to deliver drugs in situ over a sustained period of time. We hypothesized that sustained delivery of interleukin-10 (IL-10) following acute kidney injury (AKI) would mitigate the local and systemic proinflammatory cascade induced by AKI and reduce subsequent fibrosis. Wild-type C57BL/6 mice underwent ischemia-reperfusion AKI with avertin anesthesia. Three days later, mice were treated with either hyaluronic acid injectable hydrogel with or without IL-10, or IL-10 suspended in saline, injected under the capsule of the left kidney, or hydrogel with IL-10 injected subcutaneously. Untreated AKI served as controls. Serial in vivo optical imaging tracked the location and degradation of the hydrogel over time. Kidney function was assessed serially. Animals were killed 28 days following AKI and the following were evaluated: serum IL-6, lung inflammation, urine neutrophil gelatinase-associated lipocalin, and renal histology for fibroblast activity, collagen type III deposition and fibrosis via Picrosirius Red staining and second harmonic imaging. Our model shows persistent systemic inflammation, and renal inflammation and fibrosis 28 days following AKI. The hydrogels are biocompatible and reduced serum IL-6 and renal collagen type III 28 days following AKI even when delivered without IL-10. Treatment with IL-10 reduced renal and systemic inflammation, regardless of whether the IL-10 was delivered in a sustained manner via the injectable hydrogel under the left kidney capsule, as a bolus injection via saline under the left kidney capsule, or via the injectable hydrogel subcutaneously. Injectable hydrogels are suitable for local drug delivery following renal injury, are biocompatible, and help mitigate local and systemic inflammation. Copyright © 2016 the American Physiological Society.

  3. Mepolizumab Injection

    Science.gov (United States)

    ... or do not go away: pain, redness, swelling, warmth, burning, or itching in the place mepolizumab was injected headache dry and itchy skin with or without red, scaly rashes back pain muscle spasms Some side ...

  4. Metoclopramide Injection

    Science.gov (United States)

    ... and feeling of fullness that lasts long after meals. Metoclopramide injection is also used to prevent nausea ... tranylcypromine (Parnate); narcotic medications for pain; sedatives; sleeping pills; tetracycline (Bristacycline, Sumycin); tranquilizers. Your doctor may need ...

  5. Ramucirumab Injection

    Science.gov (United States)

    ... dose of ramucirumab injection. Tell your doctor or nurse if you experience any of the following while you receive ramucirumab: uncontrollable shaking of a part of the body; back pain or spasms; chest pain and tightness; chills; flushing; ...

  6. Alemtuzumab Injection

    Science.gov (United States)

    Alemtuzumab injection is used to treat B-cell chronic lymphocytic leukemia (a slowly developing cancer in which ... of white blood cell accumulate in the body). Alemtuzumab is in a class of medications called monoclonal ...

  7. Ferumoxytol Injection

    Science.gov (United States)

    Ferumoxytol injection is used to treat iron-deficiency anemia (a lower than normal number of red blood ... pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or ...

  8. Fludarabine Injection

    Science.gov (United States)

    Fludarabine injection is used to treat chronic lymphocytic leukemia (CLL; a type of cancer of the white ... a reliable method of birth control to prevent pregnancy during this time. Talk to your doctor for ...

  9. Insulin Injection

    Science.gov (United States)

    ... or buttocks. Do not inject insulin into muscles, scars, or moles. Use a different site for each ... you are using insulin.Alcohol may cause a decrease in blood sugar. Ask your doctor about the ...

  10. Tigecycline Injection

    Science.gov (United States)

    ... in a person who was not in the hospital), skin infections, and infections of the abdomen (area between the ... that developed in people who were in a hospital or foot infections in people who have diabetes. Tigecycline injection is ...

  11. Golimumab Injection

    Science.gov (United States)

    Golimumab injection is used alone or with other medications to relieve the symptoms of certain autoimmune disorders ( ... did not help or could not be tolerated. Golimumab is in a class of medications called tumor ...

  12. Albiglutide Injection

    Science.gov (United States)

    ... will develop tumors of the thyroid gland, including medullary thyroid carcinoma (MTC; a type of thyroid cancer). ... symptoms or those listed in the IMPORTANT WARNING section, stop using albiglutide injection and call your doctor ...

  13. Dexamethasone Injection

    Science.gov (United States)

    ... body tissues,) gastrointestinal disease, and certain types of arthritis. Dexamethasone injection is also used for diagnostic testing. ... effects.tell your doctor if you have a fungal infection (other than on your skin or nails). ...

  14. Hydrocortisone Injection

    Science.gov (United States)

    ... own organs), gastrointestinal disease, and certain types of arthritis. Hydrocortisone injection is also used to treat certain ... effects.tell your doctor if you have a fungal infection (other than on your skin or nails). ...

  15. Methylprednisolone Injection

    Science.gov (United States)

    ... own organs), gastrointestinal disease, and certain types of arthritis. Methylprednisolone injection is also used to treat certain ... effects.tell your doctor if you have a fungal infection (other than on your skin or nails). ...

  16. Glatiramer Injection

    Science.gov (United States)

    ... To inject glatiramer, follow these steps: Remove one blister pack from the carton of glatiramer syringes and place ... paper label and remove the syringe from the blister pack. Check your prefilled syringe to be sure it ...

  17. Dexrazoxane Injection

    Science.gov (United States)

    ... that are used to treat or prevent certain side effects that may be caused by chemotherapy medications. Dexrazoxane injection (Zinecard) is used to prevent or decrease heart damage caused by doxorubicin in women who are ...

  18. Evolocumab Injection

    Science.gov (United States)

    ... autoinjector in hot water, microwave, or place in sunlight.Before you use evolocumab injection, look at the ... chills pain or burning during urination muscle or back pain dizziness stomach pain Some side effects can be ...

  19. Cidofovir Injection

    Science.gov (United States)

    Cidofovir injection is used along with another medication (probenecid) to treat cytomegaloviral retinitis (CMV retinitis) in people with acquired immunodeficiency syndrome (AIDS). Cidofovir is in a class of medications called antivirals. ...

  20. Brivaracetam Injection

    Science.gov (United States)

    ... older. Brivaracetam in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in ... older (about 1 in 500 people) who took anticonvulsants like brivaracetam injection to treat various conditions during ...

  1. Diphenhydramine Injection

    Science.gov (United States)

    ... not to use diphenhydramine injection if you are breastfeeding because of the risk of harm to infants.tell your doctor if you have or have ever had asthma or other types of lung disease; glaucoma (a ...

  2. Cefazolin Injection

    Science.gov (United States)

    ... valve, respiratory tract (including pneumonia), biliary tract, and urinary tract infections. Cefazolin injection also may be used before, during, ... to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( ...

  3. Ceftazidime Injection

    Science.gov (United States)

    ... skin, blood, bone, joint, female genital tract, and urinary tract infections. Ceftazidime injection is in a class of medications ... to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( ...

  4. Fluconazole Injection

    Science.gov (United States)

    ... and fungal infections of the eye, prostate (a male reproductive organ), skin and nails. Fluconazole injection is ... Motrin, others) and naproxen (Aleve, Anaprox, Naprelan); oral contraceptives (birth control pills); oral medication for diabetes such ...

  5. Moxifloxacin Injection

    Science.gov (United States)

    ... available.Moxifloxacin injection is in a class of antibiotics called fluoroquinolones. It works by killing the bacteria that cause ... you are allergic to moxifloxacin, other quinolone or fluoroquinolone antibiotics such as ciprofloxacin (Cipro), gatifloxacin (Tequin) (not available ...

  6. Levofloxacin Injection

    Science.gov (United States)

    ... available. Levofloxacin injection is in a class of antibiotics called fluoroquinolones. It works by killing bacteria that cause infections. ... severe reaction to levofloxacin; any other quinolone or fluoroquinolone antibiotic such as ciprofloxacin (Cipro), gatifloxacin (Tequin) (not available ...

  7. Ciprofloxacin Injection

    Science.gov (United States)

    ... available. Ciprofloxacin injection is in a class of antibiotics called fluoroquinolones. It works by killing bacteria that cause infections. ... reaction to ciprofloxacin or any other quinolone or fluoroquinolone antibiotic such as gatifloxacin (Tequin) (not available in the ...

  8. Alirocumab Injection

    Science.gov (United States)

    ... further decrease the amount of low-density lipoprotein (LDL) cholesterol ('bad cholesterol') in the blood. Alirocumab injection is ... antibodies. It works by blocking the production of LDL cholesterol in the body to decrease the amount of ...

  9. Chloramphenicol Injection

    Science.gov (United States)

    ... an arm or leg sudden changes in vision pain with eye movement Chloramphenicol injection may cause a condition called gray syndrome in premature and newborn infants. There have also been reports of gray ...

  10. Physicochemical and biological properties of a novel injectable polyurethane system for root canal filling

    Directory of Open Access Journals (Sweden)

    Wang J

    2015-01-01

    Full Text Available Jian Wang,1 Yi Zuo,1 Minghui Zhao,1 Jiaxing Jiang,1 Yi Man,2 Jun Wu,3 Yunjiu Hu,3 Changlei Liu,4 Yubao Li,1 Jidong Li11Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2College of Stomatology, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 3Department of Orthopedics, Chongqing Medical University, Chongqing, People’s Republic of China; 4College of Chemistry, Sichuan University, Chengdu, Sichuan, People’s Republic of ChinaAbstract: A root canal sealer with antibacterial activity can be efficacious in preventing reinfection that results from residual microorganisms and/or the leakage of microorganisms. In the present study, a series of injectable, self-curing polyurethane (PU-based antibacterial sealers with different concentrations of silver phosphate (Ag3PO4 were fabricated. Subsequently, their physicochemical properties, antibacterial abilities, and preliminary cytocompatibilities were evaluated. The results indicated that the fabricated PU-based sealers can achieve a high conversion rate in a short amount of time. More than 95% of the isocyanate group of PU sealers with 3 wt% (PU3 and 5 wt% (PU5 concentrations of Ag3PO4 were included in the curing reaction after 7 hours. With the exception of those for film thickness for PU5, the results of setting time, film thickness, and solubility were able to meet the requirements of the International Organization for Standardization. The antibacterial tests showed that PU3 and PU5 exhibit stronger antimicrobial effects than that achieved with 1 wt% Ag3PO4 (PU1 and AH Plus (positive control against Streptococcus mutans. The cytocompatibility evaluation revealed that the PU1 and PU3 sealers possess good cytocompatibility and low cytotoxicity. These results demonstrate that the PU3 sealer offers good physicochemical and antimicrobial properties along with cytocompatibility, which may hold great

  11. Experimental Study of SBLOCA Simulation of Safety-Injection Line Break with Single Train Passive Safety System of SMART-ITL

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Sung Uk; Bae, Hwang; Ryu, Hyo Bong; Byun, Sun Joon; Kim, Woo Shik; Shin, Yong Cheol; Yi, Sung Jae; Park, Hyun Sik [KAERI, Daejon (Korea, Republic of)

    2016-03-15

    An experimental study of the thermal-hydraulic characteristics of passive safety systems (PSSs) was conducted using a system-integrated modular advanced reactor-integral test loop (SMART-ITL). The present passive safety injection system for the SMART-ITL consists of one train with the core makeup tank (CMT), the safety injection tank, and the automatic depressurization system. The objective of this study is to investigate the injection effect of the PSS on the small-break loss-of-coolant accident (SBLOCA) scenario for a 0.4 inch line break in the safety-injection system (SIS). The steady-state condition was maintained for 746 seconds before the break. When the major parameters of the target value and test results were compared, most of the thermal-hydraulic parameters agreed closely with each other. The water level of the reactor pressure vessel (RPV) was maintained higher than that of the fuel assembly plate during the transient, for the present CMT and safety injection tank (SIT) flow rate conditions. It can be seen that the capability of an emergency core cooling system is sufficient during the transient with SMART passive SISs.

  12. Evaluation of a novel PTFE material for separation and preconcentration of trace levels of metal ions in sequential injection (SI) and sequential injection lab-on-valve (SI-LOV) systems interfaced with detection by ETAAS

    DEFF Research Database (Denmark)

    Long, Xiangbao; Chomchoei, Roongrat; Gała, Piotr

    The operational characteristics of a novel PTFE bead material, granular Algoflon®, used for separation and preconcentration of metal ions via adsorption of on-line generated non-charged metal complexes, were evaluated in a sequential injection (SI) system furnished with an external packed column...... and in a sequential injection lab-on-valve (SI-LOV) system. Employed for the determination of cadmium(II), complexed with diethyldithiophosphate (DDPA), and detection by electrothermal atomic absorption spectrometry (ETAAS), its performance was compared to that of a previously used material, Aldrich PTFE, which had...... demonstrated that PTFE was the most promising for solid-state pretreatments. By comparing the two materials, the Algoflon® beads exhibited much higher sensitivity (1.6107 versus 0.2956 μg l-1 per integrated absorbance (s)), and better retention efficiency (82% versus 74%) and enrichment factor (20.8 versus 17...

  13. A tetra-layer microfluidic system for peptide affinity screening through integrated sample injection.

    Science.gov (United States)

    Wang, Weizhi; Huang, Yanyan; Jin, Yulong; Liu, Guoquan; Chen, Yi; Ma, Huimin; Zhao, Rui

    2013-05-21

    A novel integrated microfluidic system was designed and fabricated for affinity peptide screening with in situ detection. A tetra-layer microfluidic hybrid chip containing two top eccentric diffluent layers, an inter-layer and a bottom screening layer, was developed as the core device of the system. The eccentric diffluent layers were ingeniously invented for the vertical sample delivery from 2 top-inlets into 12 bottom-inlets, which eliminated the use of excessive accessories and complicated pipelines currently used in other systems. By using six pH gradient generators, the magnetic bead-based screening in 36 parallel chambers was simultaneously carried out under 6 different pH conditions from 5.4 to 8.2. This allowed simultaneous screening of 6 compounds and each under 6 different pH conditions. The fabricated chip system was applied to screening of affinity peptides towards β-endorphin antibody. The affinities of the peptide ligands to the antibody were assessed by on-chip confocal detection. The results from the screening study using this system indicated that the pentapeptide with the sequence of YGGFL had the highest affinity towards β-endorphin antibody at pH 7.1, which was further confirmed by the ELISA assay using a 96-well plate format. This microfluidic screening system is automatic, low-cost and reusable for not only peptide screening but also other bioactive compounds screening towards target molecules.

  14. An RF driven H{sup {minus}} source and a low energy beam injection system for RFQ operation

    Energy Technology Data Exchange (ETDEWEB)

    Leung, K.N.; Bachman, D.A.; Chan, C.F.; McDonald, D.S.

    1992-12-31

    An RF driven H{sup {minus}} source has been developed at LBL for use in the Superconducting Super Collider (SSC). To date, an H{sup {minus}} current of {approx}40 mA can be obtained from a 5.6-cm-diam aperture with the source operated at a pressure of about 12 m Torr and 50 kW of RF power. In order to match the accelerated H{sup {minus}} beam into the SSC RFQ, a low-energy H{sup {minus}} injection system has been designed. This injector produces an outgoing H{sup {minus}} beam free of electron contamination, with small radius, large convergent angle and small projectional emittance.

  15. Atomic absorption spectroscopy for mercury, automated by sequential injection and miniaturized in lab-on-valve system.

    Science.gov (United States)

    Erxleben, Holger; Ruzicka, Jaromir

    2005-08-15

    Sodium borohydride-based hydride generation was automated by using programmable flow within the lab-on-valve module. Mercury vapor, generated in the reaction mixture, was extracted in a gas/liquid separator. The gas-expansion separator was miniaturized and compared with the performance of a novel gas separator that exploits the combination of Venturi effect and reduced pressure. Cold vapor atomic spectroscopy was used as a model system, with detection of mercury by absorption at 254 nm and limit of detection of 9 microg of Hg/L, using 300 microL of sample and 100 microL of borohydride. This work introduces, for the first time, sequential injection technique for hydride generation, highlights advantages of using programmable flow, and outlines means for miniaturization of assays based on spectroscopy of volatile species.

  16. Flow-injection chemiluminescence determination of acetylsalicylic acid based on its enhancing effect on the lucigenin–hydrogen peroxide system.

    Science.gov (United States)

    Wabaidur, S M; Alam, S M; Alothmana, Z A; Eldesokya, Gaber

    2014-09-01

    A sensitive flow-injection chemiluminescence method for the determination of acetylsalicylic acid is described. It is based on the enhanced chemiluminescent emission of the alkaline lucigenin–H2O2 system by acetylsalicylic acid. The difference in chemiluminescent intensity of alkaline lucigenin–H2O2 in the presence of acetylsalicylic acid from that in the absence of acetylsalicylic acid was linear at acetylsalicylic acid concentrations in the range of 0.0029–47.37 μg/mL, with detection and quantification limits of 0.0011 and 0.0029 μg/mL, respectively. The correlation coefficient of the working curve was 0.9983. The relative standard deviation (n = 10) for 25 μg/mL acetylsalicylic acid is 1.95%. All experimental parameters were optimized. The method was successfully applied to the determination of acetylsalicylic acid in pharmaceutical preparations. The recovery results obtained by the method were satisfactory.

  17. A novel flow-injection analysis system for evaluation of antioxidants by using sodium dichloroisocyanurate as a source of hypochlorite anion.

    Science.gov (United States)

    Ichiba, H; Hanami, K; Yagasaki, K; Tanaka, M; Ito, H; Fukushima, T

    2012-02-01

    A flow injection analysis (FIA) system for evaluation of the antioxidant activity of a compound capable of scavenging a hypochlorite anion (OCl⁻), one of the reactive oxygen species (ROS), was developed. Aminophenyl fluorescein (APF), a fluorescence indicator of ROS, was mixed manually with the test compounds and the mixed solution was injected into the FIA system. The injected solution was reacted in-line with OCl⁻, that was produced by using sodium dichloroisocyanurate in the presence of 0.1 M CH3CO2Na in H2O. The fluorescence intensity of fluorescein generated from non-fluorescent APF was significantly attenuated in compounds that had a scavenging effect on OCl⁻. The precision obtained by the FIA system was satisfactory (relative standard deviation OCl⁻. Therefore, the proposed FIA system can be used as a screening assay for OCl⁻-scavenging compounds.

  18. Stabilization of periodic solutions in a tethered satellite system by damping injection

    DEFF Research Database (Denmark)

    Larsen, Martin Birkelund; Blanke, Mogens

    2009-01-01

    presents a control design for stabilizing these periodic solutions. The design consists of a control law for stabilizing the open-loop equilibrium and a bias term which forces the system trajectory away from the equilibrium. The tether needs to be positioned away from open-loop equilibrium for the tether...... to affect the orbit parameters. An approximation of the periodic solutions of the closed loop system is found as a series expansion in the parameter plane spanned by the controller gain and the bias term. The stability of the solutions is investigated using linear Floquet analysis of the variational...

  19. Development of a direct-injected natural gas engine system for heavy-duty vehicles: Final report phase 2

    Energy Technology Data Exchange (ETDEWEB)

    Cox, G.B.; DelVecchio, K.A.; Hays, W.J.; Hiltner, J.D.; Nagaraj, R.; Emmer, C.

    2000-03-02

    This report summarizes the results of Phase 2 of this contract. The authors completed four tasks under this phase of the subcontract. (1) They developed a computational fluid dynamics (CFD) model of a 3500 direct injected natural gas (DING) engine gas injection/combustion system and used it to identify DING ignition/combustion system improvements. The results were a 20% improvement in efficiency compared to Phase 1 testing. (2) The authors designed and procured the components for a 3126 DING engine (300 hp) and finished assembling it. During preliminary testing, the engine ran successfully at low loads for approximately 2 hours before injector tip and check failures terminated the test. The problems are solvable; however, this phase of the program was terminated. (3) They developed a Decision & Risk Analysis model to compare DING engine technology with various other engine technologies in a number of commercial applications. The model shows the most likely commercial applications for DING technology and can also be used to identify the sensitivity of variables that impact commercial viability. (4) MVE, Inc., completed a preliminary design concept study that examines the major design issues involved in making a reliable and durable 3,000 psi LNG pump. A primary concern is the life of pump seals and piston rings. Plans for the next phase of this program (Phase 3) have been put on indefinite hold. Caterpillar has decided not to fund further DING work at this time due to limited current market potential for the DING engine. However, based on results from this program, the authors believe that DI natural gas technology is viable for allowing a natural gas-fueled engine to achieve diesel power density and thermal efficiency for both the near and long terms.

  20. Computer controlled-flow injection potentiometric system based on virtual instrumentation for the monitoring of metal-biosorption processes.

    Science.gov (United States)

    Florido, A; Valderrama, C; Nualart, S; Velazco-Molina, L; Arias de Fuentes, O; del Valle, M

    2010-05-23

    A completely automated flow-injection system was developed for the monitoring of biosorption studies of Cu(II) ion on vegetable waste by-products. The system employed flow-through Cu(II)-selective electrodes, of epoxy-resin-CuS/Ag(2)S heterogeneous crystalline type, and computer controlled pumps and valves for the flow operation. Computer automation was done through a specially devised virtual instrument, which commanded and periodically calibrated the system, allowing for the monitoring of Cu(II) ions between 0.6 and 6530 mg L(-1) at a typical frequency of 15 h(-1). Grape stalk wastes were used as biosorbent to remove Cu(II) ions in a fixed-bed column with a sorption capacity of 5.46 mg g(-1), obtained by the developed flow system, while the reference determination performed by FAAS technique supplied a comparable value of 5.41 mg g(-1). Copyright 2010 Elsevier B.V. All rights reserved.

  1. Evaluation of Coordinate Compensator Structure Based on Power Injection Model for Loading Margin Enhancement in Power Systems

    Directory of Open Access Journals (Sweden)

    Reza Sedaghati

    2013-09-01

    Full Text Available In this paper, the structure of Hybrid Power Flow Controller (HPFC is proposed in order to improve static voltage stability characteristics. HPFC forms a hybrid controller using IPFC series converters as a hybrid with existing parallel and passive compensator (SVC in power system. Utilization of hybrid structures makes it possible to use converters for improving performance of both old and existing compensators in power networks. In this study, the power injection model (PIM is used to model the hybrid power flow controller in Newton load flow. The aforementioned model is simulated in MATLAB software. The P-V curves of PQ buses of a typical system are evaluated by a continuous power flow (CPF method to analyses the effect of this controller on static voltage stability characteristics. Meanwhile, SVC as existing devices in the system and UPFC and IPFC as state-of-the-art compensator devices are compared with the proposed hybrid structure. The amount of active and reactive power loss and improvement of loading limit of the system are used as main parameters in our comparison.

  2. Stabilization of Periodic Solutions in a Thedered Satellite System by Damping Injection

    DEFF Research Database (Denmark)

    Larsen, Martin Birkelund; Blanke, Mogens

    2009-01-01

    presents a control design for stabilizing these periodic solutions. The design consists of a control law for stabilising the open-loo equibrilibrium and a bias term which forces the system trajectory away from the equilibrium. The tether needs to be positioned away from open-loop equilibrium for the tether...

  3. REDUCED PERMEABILITY IN GROUNDWATER REMEDIATION SYSTEMS: ROLE OF MOBILIZED COLLOIDS AND INJECTED CHEMICALS

    Science.gov (United States)

    The success of pump-and-treat or in situ remediation of contaminated aquifers depends in part on the ability to maintain the permeability of the aquifer, withdrawal wells, and delivery systems at a reasonable cost while moving significant quantities of water. We have considered o...

  4. Stabilization of periodic solutions in a tethered satellite system by damping injection

    DEFF Research Database (Denmark)

    Larsen, Martin Birkelund; Blanke, Mogens

    2009-01-01

    presents a control design for stabilizing these periodic solutions. The design consists of a control law for stabilizing the open-loop equilibrium and a bias term which forces the system trajectory away from the equilibrium. The tether needs to be positioned away from open-loop equilibrium for the tether...

  5. DEMONSTRATION BULLETIN: PNEUMATIC FRACTURING EXTRACTION™ AND HOT GAS INJECTION, PHASE I - ACCUTECH REMEDIAL SYSTEMS, INC.

    Science.gov (United States)

    The Pneumatic Fracturing Extraction(PFE) process developed by Accutech Remedial Systems, Inc. makes it possible to use vapor extraction to remove volatile organics at increased rates from a broader range of vadose zones. The low permeability of silts, clays, shales, etc. would ot...

  6. Strategies of detecting Profile-injection attacks in E-Commerce Recommender System: A survey Partha

    Directory of Open Access Journals (Sweden)

    Sarathi Chakraborty,

    2015-12-01

    Full Text Available E-commerce recommender systems are vulnerable to different types of shilling attack where the attacker influences the recommendation procedure in favor of him by inserting fake user-profiles into the system. From one point of view, the attacks can be of type push or nuke-either to promote or to demote a product. On the other hand, attacks can be classified as high-knowledge or low-knowledge attack depending on the amount of system knowledge required for making the attack successful. Several research works have been done in the last two decades for defending attacks on recommender systems. In this paper, we have surveyed the major works done in this area by different researchers. After a brief explanation of different attack types and attack models, we discussed the attack detection strategies proposed by the researchers mainly under five categories- Generic and model specific attribute based, rating distribution based, outlier analysis based, statistical approach based and clustering based.

  7. Injecting a liquid bacteria-based repair system to make porous network conrete healed

    NARCIS (Netherlands)

    Sangadji, S.; Wiktor, V.A.C.; Jonkers, H.M.; Schlangen, H.E.J.G.

    2013-01-01

    Bacteria induced calcite precipitation has been proven to be effective in making concrete structure self-healing. In Microlab TU Delft, the concept has been enhanced by developing a liquid bacteria-based concrete repair system. The solution contains calcite precipitating bacteria, nutrients and buff

  8. Flow Injection Analysis and Liquid Chromatography for Multifunctional Chemical Analysis (MCA) Systems

    Science.gov (United States)

    Mayo, Ana V.; Loegel, Thomas N.; Bretz, Stacey Lowery; Danielson, Neil D.

    2013-01-01

    The large class sizes of first-year chemistry labs makes it challenging to provide students with hands-on access to instrumentation because the number of students typically far exceeds the number of research-grade instruments available to collect data. Multifunctional chemical analysis (MCA) systems provide a viable alternative for large-scale…

  9. A Traffic injection methodology with support for system-level synchronization

    DEFF Research Database (Denmark)

    Mahadevan, Shankar; Angiolini, Federico; Sparsø, Jens;

    2007-01-01

    models to be still unavailable when tuning communication performance. Traditionally, synthetic traffic generators have been used to overcome such an issue. However, target applications increasingly present non-trivial execution flows and synchronization patterns, especially in presence of underlying...... operating systems and when exploiting interrupt facilities. This property makes it very difficult to generate realistic test traffic. This paper presents a selection of application flows, representative of a wide class of applications with complex interrupt-based synchronization; a reference methodology...

  10. Efficient, radiation-hardened, 400- and 800-keV neutral-beam injection systems

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, O.A.; Cooper, W.S.; Fink, J.A.; Goldberg, D.A.; Ruby, L.; Soroka, L.; Tanabe, J.

    1983-04-01

    We present designs for two negative-ion based neutral beam lines with reactor-level power output. Both beam lines make use of such technologically advanced features as high-current-density surface-conversion ion sources, transverse-field-focussing (TFF) acceleration and transport, and laser photodetachment. For the second of these designs, we also presented detailed beam and vacuum calculations, as well as a brief description of a proof-of-principle test system currently under development.

  11. Exploiting the Automatic Dependent Surveillance-Broadcast System via False Target Injection

    Science.gov (United States)

    2012-03-01

    IEEE Xplore . 8. Hal Stoen. (2001) VFR Flight. Retrieved February 15, 2012 from http://stoenworks.com/vfr%20flight.html 9. Cohen, B., & Smith, A...7. Gilbert, G. (1973). Historical development of the air traffic control system. IEEE Transactions on Communications, 364-375. Retrieved from...1998. Proceedings., 17th DASC. the AIAA/ IEEE /SAE,2 F44/1- F44/8 vol.2. 10. Livack, G. S., McDaniel, J. I., Battiste, V., & Johnson, W. W. (2000

  12. Serological response to administration of Brucella abortus strain RB51 vaccine in beef and dairy heifers, using needle-free and standard needle-based injection systems

    Science.gov (United States)

    The purpose of this study was to compare immunologic responses of heifers vaccinated with 10**10 colony-forming units (CFU) of Brucella abortus strain RB51 (SRB51) by standard needle-and-syringe system or a needle-free injection system. Heifers were randomly assigned to control and vaccination gro...

  13. Improved performance of the JAERI injection and free electron laser system

    CERN Document Server

    Nishimori, N; Hajima, R; Shizuma, T; Sawamura, M; Kikuzawa, N; Minehara, E J

    2000-01-01

    Several modifications have been made for the JAERI Free Electron Laser (FEL) system in order to extract greater average lasing power. The electron gun was improved to produce an electron beam with 1 ns pulse width, 600 mA peak current, amplitude fluctuation less than 1% and timing jitter less than 0.1 ns. In addition, the 180 deg. bending arc was modified to match the beam envelope inside the undulator. After these modifications, we obtained an FEL power of 180 W in macro-pulse average at wavelength of 23 mu m.

  14. Experimental Validation of RELAP5 and TRACE5 for Licensing Studies of the Boron Injection System of Atucha II

    Directory of Open Access Journals (Sweden)

    Alejandro I. Lazarte

    2011-01-01

    Full Text Available This paper presents an experimental validation of RELAP5 and TRACE5 for licensing studies of the Atucha II-PHWR nuclear power plant. A scaled experimental facility, representing the boron injection system of Atucha II, was built. The system has a fundamental importance for loss of coolant accidents (LOCA and anticipated transients without scram (ATWS. The experiment consists of the discharge of a tank that represents the boron tank filled with air or a mixture of air-water onto a discharge tank that represents the moderator tank. Both tanks are connected by a pipe which includes a valve and an orifice plate to model the pressure losses due to the fittings in the real system. The pressure and water level measured in the tanks are compared with the RELAP5 and TRACE5 predictions. The codes predict the pressure in the tanks accurately. However, both codes overpredict the heat transfer in the boron tank air-water interface which produces a greater expansion of the air which leads to a small discrepancy in the boron tank level prediction.

  15. A Comparative Analysis of Taguchi Methodology and Shainin System DoE in the Optimization of Injection Molding Process Parameters

    Science.gov (United States)

    Khavekar, Rajendra; Vasudevan, Hari, Dr.; Modi, Bhavik

    2017-08-01

    Two well-known Design of Experiments (DoE) methodologies, such as Taguchi Methods (TM) and Shainin Systems (SS) are compared and analyzed in this study through their implementation in a plastic injection molding unit. Experiments were performed at a perfume bottle cap manufacturing company (made by acrylic material) using TM and SS to find out the root cause of defects and to optimize the process parameters for minimum rejection. Experiments obtained the rejection rate to be 8.57% from 40% (appx.) during trial runs, which is quiet low, representing successful implementation of these DoE methods. The comparison showed that both methodologies gave same set of variables as critical for defect reduction, but with change in their significance order. Also, Taguchi methods require more number of experiments and consume more time compared to the Shainin System. Shainin system is less complicated and is easy to implement, whereas Taguchi methods is statistically more reliable for optimization of process parameters. Finally, experimentations implied that DoE methods are strong and reliable in implementation, as organizations attempt to improve the quality through optimization.

  16. Sequential injection system for phospholipase A2 activity evaluation: studies on liposomes using an environment-sensitive fluorescent probe.

    Science.gov (United States)

    Araujo, André R T S; Gaspar, Diana; Lúcio, Marlene; Reis, Salette; Saraiva, M Lúcia M F S; Lima, José L F C

    2009-09-15

    This work reports the development of an automatic methodology based on the use of 1-anilinonaphthalene-8-sulfonate (ANS) as an interfacial fluorescent probe for detecting the hydrophobic environment shift around the probe, caused by the hydrolytic action of PLA(2) on the liposomes. The implementation of this reaction in a sequential injection analysis (SIA) system along with the use of the mixing chambers permitted the evaluation of PLA(2) activity and assessment of the inhibitory effect of the non-steroidal anti-inflammatory drugs (NSAIDs) on PLA(2) activity. Several studies were performed with the aim of establishing the appropriate flow system configuration: the liposome substrate; PLA(2) and ANS optimum concentrations and incubation times before and after the enzyme addition. Based on these studies, the optimum reaction conditions were selected. It was shown that PLA(2) is effectively inhibited by the NSAIDs tested (meloxicam, tolmetin and ibuprofen) and by the alpha-lipoic acid, used as a positive control. Results obtained from the flow system are in agreement with those provided by the comparison batch procedures. The proposed methodology is in fact more efficient and rapid than the comparison batch experiments, enabling the exact timing of fluidic manipulations and precise control of the reaction conditions.

  17. Flow injection potentiometric system for the simultaneous determination of inositol phosphates and phosphate: phosphorus nutritional evaluation on seeds and grains.

    Science.gov (United States)

    Parra, Aleix; Ramon, Meritxell; Alonso, Julián; Lemos, Sherlan G; Vieira, Edivan C; Nogueira, Ana R A

    2005-10-05

    A simple flow injection potentiometric (FIP) system, which uses a tubular cobalt electrode, has been developed for phosphorus nutritional evaluation of seeds and grains. Inorganic phosphorus, P(i), is determined using a 1 x 10(-2) mol.L(-1) potassium phthalate buffer solution adjusted at pH 4. A sensitivity of 47 mV/decade and an operating range from 10 to 1000 mg.L(-1) (1 x 10(-4)-1 x 10(-2) M) of dihydrogen phosphate are obtained. The inositol phosphates amount, which is referred to the organic phosphorus, P(org), is directly determined from extracts using a 1 x 10(-2) mol.L(-1) Tris-HCl buffer solution adjusted at pH 8. A sensitivity of 127 mV/decade and an operating range of 10-1000 mg.L(-1) (2.5 x 10(-4)-5 x 10(-3) M) of P(org) (expressed as inositol hexakisphosphoric acid monocalcium) are achieved. Some samples of seed and grain are analyzed by an ICP-OES and a spectrophotometric method to compare results to the developed flow system; no significant differences at the 95% confidence level are observed using a paired t test. Other samples such as animal nursing feed, soybean meal, and corn are also analyzed with the proposed FIP system, showing a good correlation to the ICP-OES values.

  18. Systemic effects of locally injected platelet rich plasma in a rat model: an analysis on muscle and bloodstream.

    Science.gov (United States)

    Borrione, P; Grasso, L; Racca, S; Abbadessa, G; Carriero, V; Fagnani, F; Quaranta, F; Pigozzi, F

    2015-01-01

    Abundant evidence suggests that growth factors, contained in platelets alpha granules, may play a key role in the early stages of the muscle healing process with particular regard to the inflammatory phase. Although the contents of the platelet-rich plasma preparations have been extensively studied, the biological mechanisms involved as well as the systemic effects and the related potential doping implications of this approach are still largely unknown. The aim of the present study was to investigate whether local platelet-rich plasma administration may modify the levels of specific cytokines and growth factors both in treated muscle and bloodstream in rats. An additional aim was to investigate more deeply whether the local platelet-rich plasma administration may exert systemic effects by analyzing contralateral lesioned but untreated muscles. The results showed that platelet-rich plasma treatment induced a modification of certain cytokines and growth factor levels in muscle but not in the bloodstream, suggesting that local platelet-rich plasma treatment influenced directly or, more plausibly, indirectly the synthesis or recruitment of cytokines and growth factors at the site of injury. Moreover, the observed modifications of cytokine and growth factor levels in contralateral injured but not treated muscles, strongly suggested a systemic effect of locally injected platelet-rich plasma.

  19. New processing route for ZrSiO{sub 4} by powder injection moulding using an eco-friendly binder system

    Energy Technology Data Exchange (ETDEWEB)

    Abajo, C.; Jimenez-Morales, A.; Torralba, J. M.

    2015-10-01

    New processing route has been developed for zircon based on powder injection moulding (PIM). Raw zircon powders, obtained from mineral sands, have been processed using a new water soluble binder system composed of PEG and CAB. Water solvent debinding stage has been studied in depth. On one hand, influence of some debinding parameters (temperature, debinding rate, additives and the use of climate chamber) has been tested. On the other hand, new binder systems were tested and compared with previous studied ones. The full PIM process has been carried out. Mixing, injection molding, solvent and thermal debinding and finally sintering, have been performed with the optimal binder system composition. Homogeneity along the process has been assessed by thermo-gravimetric analysis and by density measurements. After sintering, dimensional variation, density and fracture surface obtained after flexural strength test, have been analyzed. A competitive flexural strength has been achieved for injected zircon samples. (Author)

  20. System Identification Based Proxy Model of a Reservoir under Water Injection

    Directory of Open Access Journals (Sweden)

    Berihun M. Negash

    2017-01-01

    Full Text Available Simulation of numerical reservoir models with thousands and millions of grid blocks may consume a significant amount of time and effort, even when high performance processors are used. In cases where the simulation runs are required for sensitivity analysis, dynamic control, and optimization, the act needs to be repeated several times by continuously changing parameters. This makes it even more time-consuming. Currently, proxy models that are based on response surface are being used to lessen the time required for running simulations during sensitivity analysis and optimization. Proxy models are lighter mathematical models that run faster and perform in place of heavier models that require large computations. Nevertheless, to acquire data for modeling and validation and develop the proxy model itself, hundreds of simulation runs are required. In this paper, a system identification based proxy model that requires only a single simulation run and a properly designed excitation signal was proposed and evaluated using a benchmark case study. The results show that, with proper design of excitation signal and proper selection of model structure, system identification based proxy models are found to be practical and efficient alternatives for mimicking the performance of numerical reservoir models. The resulting proxy models have potential applications for dynamic well control and optimization.

  1. Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: roles of the peripheral vasopressin and central cholinergic systems

    Directory of Open Access Journals (Sweden)

    B. Cam-Etoz

    2012-03-01

    Full Text Available Our objective was to investigate in conscious Sprague-Dawley (6-8 weeks, 250-300 g female rats (N = 7 in each group the effects of intracerebroventricularly (icv injected adrenomedullin (ADM on blood pressure and heart rate (HR, and to determine if ADM and calcitonin gene-related peptide (CGRP receptors, peripheral V1 receptors or the central cholinergic system play roles in these cardiovascular effects. Blood pressure and HR were observed before and for 30 min following drug injections. The following results were obtained: 1 icv ADM (750 ng/10 µL caused an increase in both blood pressure and HR (DMAP = 11.8 ± 2.3 mmHg and ΔHR = 39.7 ± 4.8 bpm. 2 Pretreatment with a CGRP receptor antagonist (CGRP8-37 and ADM receptor antagonist (ADM22-52 blocked the effect of central ADM on blood pressure and HR. 3 The nicotinic receptor antagonist mecamylamine (25 µg/10 µL, icv and the muscarinic receptor antagonist atropine (5 µg/10 µL, icv prevented the stimulating effect of ADM on blood pressure. The effect of ADM on HR was blocked only by atropine (5 µg/10 µL, icv. 4 The V1 receptor antagonist [β-mercapto-β-β-cyclopentamethylenepropionyl¹, O-me-Tyr²,Arg8]-vasopressin (V2255; 10 µg/kg, that was applied intravenously, prevented the effect of ADM on blood pressure and HR. This is the first study reporting the role of specific ADM and CGRP receptors, especially the role of nicotinic and muscarinic central cholinergic receptors and the role of peripheral V1 receptors in the increasing effects of icv ADM on blood pressure and HR.

  2. Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: roles of the peripheral vasopressin and central cholinergic systems

    Energy Technology Data Exchange (ETDEWEB)

    Cam-Etoz, B.; Isbil-Buyukcoskun, N.; Ozluk, K. [Department of Physiology, Uludag University Medical Faculty, Gorukle/Bursa (Turkey)

    2012-03-02

    Our objective was to investigate in conscious Sprague-Dawley (6-8 weeks, 250-300 g) female rats (N = 7 in each group) the effects of intracerebroventricularly (icv) injected adrenomedullin (ADM) on blood pressure and heart rate (HR), and to determine if ADM and calcitonin gene-related peptide (CGRP) receptors, peripheral V{sub 1} receptors or the central cholinergic system play roles in these cardiovascular effects. Blood pressure and HR were observed before and for 30 min following drug injections. The following results were obtained: 1) icv ADM (750 ng/10 µL) caused an increase in both blood pressure and HR (ΔMAP = 11.8 ± 2.3 mmHg and ΔHR = 39.7 ± 4.8 bpm). 2) Pretreatment with a CGRP receptor antagonist (CGRP{sub 8-37}) and ADM receptor antagonist (ADM{sub 22-52}) blocked the effect of central ADM on blood pressure and HR. 3) The nicotinic receptor antagonist mecamylamine (25 µg/10 µL, icv) and the muscarinic receptor antagonist atropine (5 µg/10 µL, icv) prevented the stimulating effect of ADM on blood pressure. The effect of ADM on HR was blocked only by atropine (5 µg/10 µL, icv). 4) The V{sub 1} receptor antagonist [β-mercapto-β-β-cyclopentamethylenepropionyl{sup 1}, O-me-Tyr{sup 2},Arg{sup 8}]-vasopressin (V2255; 10 µg/kg), that was applied intravenously, prevented the effect of ADM on blood pressure and HR. This is the first study reporting the role of specific ADM and CGRP receptors, especially the role of nicotinic and muscarinic central cholinergic receptors and the role of peripheral V{sub 1} receptors in the increasing effects of icv ADM on blood pressure and HR.

  3. [Biopersistence and systemic distribution of intramuscularly injected particles: what impact on long-term tolerability of alum adjuvants?].

    Science.gov (United States)

    Gherardi, Romain K; Cadusseau, Josette; Authier, François-jérôme

    2014-01-01

    Aluminium oxyhydroxide (alum), a nanocrystalline compound that forms agglomerates, has been widely used as a vaccine adjuvant since 1927, but the mechanisms by which it stimulates immune responses remain poorly understood. Although generally well tolerated, alum may occasionally cause chronic health problems in presumably susceptible individuals. Some individuals may rarely develop delayed-onset diffuse myalgia, chronic exhaustion and cognitive dysfunction, associated with long-term persistence (up to 12 years) of alum-loaded macrophages at site of i.m. immunization, defining so-called macrophagic myofasciitis (MMF). Symptoms are consistent with the chronic fatigue/myalgic encephalomyelitis (CFS/ME) syndrome, and have been used as a paradigm of the "autoimmune/inflammatory syndrome induced by adjuvants" (ASIA). Cognitive dysfunction is reminiscent of that described in workers exposed to inhaled Al particles. Individual susceptibility may influence both alum biopersistence and difusion away from injection sites. Biopersistent particles such as fluorescent alum-coated nanohybrids, when injected into mouse muscle, are captured by monocyte-lineage cells and then carried to distant organs, draining lymph nodes and blood, probably via the thoracic duct, with delayed and accumulative translocation to the brain (microglial cells). Brain penetration occurs at extremely low levels in normal conditions, possibly explaining the good tolerance of alum despite its high neurotoxic potential. However, systemic diffusion is considerably enhanced by the potentiating effect of MCP-1, the main monocyte chemoattractant factor, the production of which is subject to marked variations linked to age and to genetic and environmental factors. Selective MCP-1 elevation is the only known circulating biomarker of MMF.

  4. Electrically assisted turbocompound systems for high speed direct injection diesel engines

    Energy Technology Data Exchange (ETDEWEB)

    Shahed, S.M.; Beatty, D.J. [Allied Signal Turbocharging Systems (United States)

    1999-07-01

    Turbocharged diesel engines are already the most efficiency prime movers. Further fuel economy gains are being realized by down-sizing engines but with compromised response. AlliedSignal's Electrical Turbocompounding system solves this challenge and further improves fuel economy and power density. It provides additional boost at low speeds and transfers excess turbocharger power to the crankshaft at high speeds. Analysis using a typical baseline engine shows that at low speeds, boost is increased by 100 to 407 mbars and torque by 12 to 50%, by supplying 0.5 to 2.0 kW power assist. At high speeds, up to 10kW of power can be recovered from the turbocharger, improving efficiency by 6-10%. Transient response analysis shows that with electrical assist turbochargers can reach full boost within 0.3-0.5 seconds. (author)

  5. Postaurical injection is a systemic delivery supported by symmetric distribution of Gd-DOTA in both the ipsilateral and contralateral ears☆

    Institute of Scientific and Technical Information of China (English)

    Jing Zou

    2015-01-01

    Postaurical injection of therapeutics was recently applied in clinical practice to treat inner ear diseases based on supposed existence of a direct channel from the postaurical area to the inner ear. Doubting on the associated reports and aiming to provide evidence on the inner ear uptake mechanism, the present study tracked the dynamic distribution of gadolinium-tetra-azacyclo-dodecane-tetra-acetic acid (Gd-DOTA) in rat inner ears after postaurical injection using MRI. A targeted tympanic medial wall delivery was utilized as control. The results showed that, at the early time points after postaurical injection, Gd-DOTA distributed mainly in tissues surrounding the bulla, temporal bone and skull and neck space. In the inner ear, there was gradual uptake of Gd-DOTA on both the ipsilateral and contralateral sides with equal signal intensities. There was no sign of direct channel carrying the agent from the postaurical area to the inner ear. Targeted tympanic medial wall delivery induced significantly greater uptake of Gd-DOTA in the inner ear than did postaurical injection. At 30 min post-administration, targeted tympanic medial wall delivery yielded 4.6-folds higher signal intensity than did postaurical injection. The total dose of Gd-DOTA delivered by the targeted tympanic medial wall approach was only 0.1% of that delivered by postaurical injection. In conclusion, postaurical injection is a systemic administration, which is similar to hypodermic injection, rather than a focal delivery method. By contraries, targeted tympanic medial wall delivery induces fast and abundant uptake of Gd-DOTA in the ipsilateral inner ear without significant distribution in unwanted areas.

  6. Sarilumab Injection

    Science.gov (United States)

    ... the needle. Do not try to warm the medication by heating it in a microwave, placing it in warm water or in direct sunlight, or through any other method.Before injecting, check the prefilled syringe to be sure that the expiration date printed on the package has not passed. Look ...

  7. Enfuvirtide Injection

    Science.gov (United States)

    ... inject enfuvirtide into any skin that has a tattoo, scar, bruise, mole, a burn site, or has ... Enfuvirtide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: itching, swelling, pain, tingling, discomfort, ...

  8. Fluorouracil Injection

    Science.gov (United States)

    ... of a doctor who is experienced in giving chemotherapy medications for cancer. Treatment with fluorouracil injection may cause serious side effects. ... this medication.If you experience a serious side effect, you or your doctor ... (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/ ...

  9. Lanreotide Injection

    Science.gov (United States)

    Lanreotide injection is used to treat people with acromegaly (condition in which the body produces too much growth hormone, causing enlargement of the hands, feet, and facial features; joint pain; and other symptoms) who have not successfully, or cannot be treated ...

  10. Paliperidone Injection

    Science.gov (United States)

    ... the body slow movements or shuffling walk painful erection of the penis that lasts for hours cough, chills and/or other signs of infection Paliperidone injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.If you experience a ...

  11. Ziprasidone Injection

    Science.gov (United States)

    ... stiffness falling confusion sweating loss of consciousness painful erection of the penis that lasts for hours Ziprasidone injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.If you experience a ...

  12. Risperidone Injection

    Science.gov (United States)

    ... control slow movements or shuffling walk falling painful erection of the penis that lasts for hours Risperidone extended-release injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.If you experience a ...

  13. Determination of Gallic Acid by Flow Injection Analysis Based on LuminoI-AgNO3-Ag NPs Chemiluminescence System

    Institute of Scientific and Technical Information of China (English)

    李世凤; 孙惠敏; 王东; 钱莉; 朱燕; 陶善军

    2012-01-01

    A novel flow injection procedure has been developed for the determination of gallic acid based on the en- hancement function for luminol-AgNO3-Ag NPs chemiluminescence (CL) system by gallic acid. The enhancement mechanism was proposed for the reinforcing effect of the gallic acid on the CL system. The UV-vis absorption spectrum and CL emission spectrum were applied to confirm the mechanism. The method is simple, rapid and sen- sitive with a detection limit of 5 × 10^-10 g.mL-l and a linear range of 8.0 × 10^-10- 1.0 × 10-7 g.mL-1. The relative standard deviation (RSD) is 1.3% for eleven measurements of 5 × 10^-8 g-mL-1 gallic acid. The method has been successfully applied to the determination of gallic acid in Chinese proprietary medicine--Jianmin Yanhou tablets and synthesized samples.

  14. Harmonic Injection-Based Power Fluctuation Control of Three-Phase PV Systems under Unbalanced Grid Voltage Conditions

    Directory of Open Access Journals (Sweden)

    Nian-Cheng Zhou

    2015-02-01

    Full Text Available Unbalanced voltage will inevitably cause power and DC voltage fluctuations in a three-phase PV system. The deterioration of power quality will do great harm to the PV panels and the loads, so it is necessary to suppress the power fluctuations. This paper further explores the coefficients control strategy of PV converters under unbalanced voltage conditions, aiming to suppress power fluctuations by controlling the injection of some specific orders of current harmonics into the grid. In order to achieve this, the current reference of the PV inverter has been changed by bringing in two control coefficients, and the expression of each order of the current harmonics has been deduced. Based on the standards of PV systems, the regions from which the coefficients can be selected are determined. Then, by tuning these coefficients in the feasible regions, the output parameters (power fluctuation, current THD and odd harmonics can be controlled precisely. The model of this method is built and simulated in PSCAD/EMTDC, and as a result, it is shown that the power fluctuations can be restricted according to different power quality requirements.

  15. Detection of Total Phenol in Green and Black Teas by Flow Injection System and Unmodified Screen Printed Electrode

    Directory of Open Access Journals (Sweden)

    Ivanildo Luiz de Mattos

    2010-01-01

    Full Text Available A flow injection system using an unmodified gold screen-printed electrode was employed for total phenol determination in black and green teas. In order to avoid passivation of the electrode surface due to the redox reaction, preoxidation of the sample was realized by hexacyanoferrate(III followed by addition of an EDTA solution. The complex formed in the presence of EDTA minimizes or avoids polymerization of the oxidized phenols. The previously filtered tea sample and hexacyanoferrate(III reagent were introduced simultaneously into two-carrier streams producing two reproducible zones. At confluence point, the pre-oxidation of the phenolic compounds occurs while this zone flows through the coiled reactor and receives the EDTA solution before phenol detection. The consumption of ferricyanide was monitorized at 360 mV versus Ag/AgCl and reflected the total amount of phenolic compounds present in the sample. Results were reported as gallic acid equivalents (GAEs. The proposed system is robust, versatile, environmentally-friendly (since the reactive is used only in the presence of the sample, and allows the analysis of about 35–40 samples per hour with detection limit = 1 mg/L without the necessity for surface cleaning after each measurement. Precise results are in agreement with those obtained by the Folin-Ciocalteu method.

  16. Influence of binder system and temperature on rheological properties of water atomized 316L powder injection moulding feedstocks

    Directory of Open Access Journals (Sweden)

    Uğur GÖKMEN

    2016-02-01

    Full Text Available In order to obtain a proper powder injection molding the rheological behavior of feedstocks should be known. To determine the binder effect on the rheological behavior of 316L stainless steel powders feedstock two different feedstock were prepared. In the current experiments water atomized 316L stainless steel powders (-20 µm were used. Two types of binders, one of which is mainly paraffin wax can be dissolved in heptane and the other Polietilenglikol (PEG based and can be dissolved in water, were used. Polypropylene was used as binder and steric acid was used as lubricant for both binder systems as skeleton binder. Dry binder system were mixed for 30 min in a three dimensional Turbola. Capillary rheometer was used to characterize the rheological properties of feed stocks at 150-200 °C and a pressures of 0.165-2.069 MPa. Powder loading capacity of PEG and PW based feed stocks were found to be %55 and %61 respectively. The lowest viscosity of PEG and PW based feed stocks were found to be 304.707 Pa.s and 48.857 Pa.s respectively.Keywords: PIM, Binder, Rheological properties

  17. A New System for Measuring Auto-Fluorescence Changes in Neovascular-AMD after Intravitreal Injection of Bavecizumab

    Directory of Open Access Journals (Sweden)

    Mohammad Norouzifard

    2011-07-01

    Full Text Available Age-Related Macular Degeneration (AMD is the second disease diabetes which causes blindness in aged people. The only remedy for AMD is intravenous injection of bavecizumab. To prove the efficiency of remedy, the degenerated cells in Macula should be measured. In this article, a modern system is introduced to measure Auto-Fluorescence in Macula part of retina in order to obtain number of degenerated cells. The system consists of three main parts: Pre-processing stage is omission of margins and reversion of images in retina. Analysis stage is in charge of classification of images and elicitation of their features. In classification the target areas are identified by methods like morphology, dynamic threshold and connected comportments and the features of target area including Euclidean distance to the center of image and density. In the stage of understanding by gathering the features of each class, we will get the measurable parameter of evaluating Auto Fluorescence by the help of which we can count the number of degenerated cells of Macula area. The results are coming from statistical analysis, including linear regression and correlation of data. Experiments have been done on a database of 34 retina images of AMD patients. The average statistical error rate is equal to76 percent. In clinical reviews, the founded relation to disinflation of Macula has been proved, while there were no proved relations to the vision decreasing or increasing of patients.

  18. Amperometric detection of acetaminophen by an electrochemical sensor based on cobalt oxide nanoparticles in a flow injection system

    Energy Technology Data Exchange (ETDEWEB)

    Razmi, Habib, E-mail: h.razmi@azaruniv.ed [Electrochemistry Research Laboratory, Faculty of Sciences, Azarbaijan University of Tarbiat Moallem, P.O. Box 53714-161, Tabriz (Iran, Islamic Republic of); Habibi, Esmaeil [Electrochemistry Research Laboratory, Faculty of Sciences, Azarbaijan University of Tarbiat Moallem, P.O. Box 53714-161, Tabriz (Iran, Islamic Republic of)

    2010-12-01

    This paper reports the use of a carbon ceramic electrode as a highly-porous substrate for the electrochemical formation of cobalt oxide nanoparticles. The electrocatalyst was characterized by energy dispersive X-ray (EDX) spectroscopy, scanning electron microscopy (SEM) and cyclic voltammetry techniques, and it was used in a homemade flow injection analysis (FIA) system for acetaminophen determination using 0.1 M KOH as the carrier solution. The rate constant (k{sub s}) and charge transfer coefficient ({alpha}) were calculated for the electron exchange reaction of the modified film. The kinetic parameters and the mechanism of acetaminophen electrooxidation at the electrode surface were studied by cyclic voltammetry and chronoamperometry. The effects of working potential and flow rate on the performance of the FIA system were studied. Under optimized conditions, the electrode response due to the electrocatalytic oxidation of acetaminophen at 450 mV (vs. SCE) is proportional to the concentration of acetaminophen over a 5-35 {mu}M range with an associated detection limit (S/N = 3) of 0.37 {mu}M and a sensitivity of 0.0296 {mu}A/{mu}M. The relative standard deviation (RSD) was 1.6% for eight replicate measurements. The modified electrode was used to determine the acetaminophen content in tablet samples.

  19. Comparing the survival rate of juvenile Chinook salmon migrating through hydropower systems using injectable and surgical acoustic transmitters

    Science.gov (United States)

    Deng, Z. D.; Martinez, J. J.; Li, H.; Harnish, R. A.; Woodley, C. M.; Hughes, J. A.; Li, X.; Fu, T.; Lu, J.; McMichael, G. A.; Weiland, M. A.; Eppard, M. B.; Skalski, J. R.; Townsend, R. L.

    2017-01-01

    Acoustic telemetry is one of the primary technologies for studying the behavior and survival of fishes throughout the world. The size and performance of the transmitter are key limiting factors. The newly developed injectable transmitter is the first acoustic transmitter that can be implanted via injection instead of surgery. A two-part field study was conducted to evaluate the performance of the injectable transmitter and its effect on the survival of implanted fish. The injectable transmitter performed well and similarly to the proceeding generation of commercially-available JSATS transmitters tested concurrently. Snake River subyearling Chinook salmon smolts implanted with the injectable transmitter had a higher survival probability from release to each of eleven downstream detection arrays, because reach-specific survival estimates were significantly higher for the injectable group in three of the eleven reaches examined. Overall, the injectable group had a 0.263 (SE = 0.017) survival probability over the entire 500 km study area compared to 0.199 (0.012) for the surgically implanted group. The reduction in size and ability to implant the new transmitter via injection has reduced the tag or tagging effect bias associated with studying small fishes. The information gathered with this new technology is helping to evaluate the impacts of dams on fishes. PMID:28220850

  20. Comparing the survival rate of juvenile Chinook salmon migrating through hydropower systems using injectable and surgical acoustic transmitters.

    Science.gov (United States)

    Deng, Z D; Martinez, J J; Li, H; Harnish, R A; Woodley, C M; Hughes, J A; Li, X; Fu, T; Lu, J; McMichael, G A; Weiland, M A; Eppard, M B; Skalski, J R; Townsend, R L

    2017-02-21

    Acoustic telemetry is one of the primary technologies for studying the behavior and survival of fishes throughout the world. The size and performance of the transmitter are key limiting factors. The newly developed injectable transmitter is the first acoustic transmitter that can be implanted via injection instead of surgery. A two-part field study was conducted to evaluate the performance of the injectable transmitter and its effect on the survival of implanted fish. The injectable transmitter performed well and similarly to the proceeding generation of commercially-available JSATS transmitters tested concurrently. Snake River subyearling Chinook salmon smolts implanted with the injectable transmitter had a higher survival probability from release to each of eleven downstream detection arrays, because reach-specific survival estimates were significantly higher for the injectable group in three of the eleven reaches examined. Overall, the injectable group had a 0.263 (SE = 0.017) survival probability over the entire 500 km study area compared to 0.199 (0.012) for the surgically implanted group. The reduction in size and ability to implant the new transmitter via injection has reduced the tag or tagging effect bias associated with studying small fishes. The information gathered with this new technology is helping to evaluate the impacts of dams on fishes.