UV/H2O2 process performance improvement by ultrafiltration and physicochemical clarification systems for industrial effluent pretreatment

Directory of Open Access Journals (Sweden)

Ivanildo Hespanhol

2012-12-01

Full Text Available The present study evaluated the removal of TOC from an effluent with high organic load resulted from the treatment of oil-water emulsion by thermal process. Hollow Fiber Ultrafiltration membrane (HF-UF and physicochemical clarification process were used as pretreatment options to assess the influence of feed effluent quality on the UV/H2O2 oxidation process. Results for TOC removals showed HF-UF and physicochemical clarification processes can significantly improve the efficiency of UV/H2O2 oxidation process, when compared with the direct effluent oxidation. Reaction time for obtaining a TOC removal higher than 90% was reduced to approximately half of the time needed when no pretreatment was applied. Considering both pretreatment processes it was not possible to notice any significant difference on the UV/H2O2 oxidation process performance. However, the complexity of physicochemical process due to the use of three different chemicals and sludge production made the HF-UF process the best pretreatment alternative, without increasing the Total Dissolved Solids of the effluent, a very important issue when water reuse is considered.

Clarification of dissolved irradiated light-water-reactor fuel

International Nuclear Information System (INIS)

Rodrigues, G.C.

1983-02-01

Bench-scale studies with actual dissolved irradiated light water reactor (LWR) fuels showed that continuous centrifugation is a practical clarification method for reprocessing. Dissolved irradiated LWR fuel was satisfactorily clarified in a bench-scale, continuous-flow bowl centrifuge. The solids separated were successfully reslurried in water. When the reslurried solids were mixed with clarified centrate, the resulting suspension behaved similar to the original dissolver solution during centrifugation. Settling rates for solids in actual irradiated fuel solutions were measured in a bottle centrifuge. The results indicate that dissolver solutions may be clarified under conditions achievable by available plant-scale centrifuge technology. The effective particle diameter of residual solids was calculated to be 0.064 microns for Oconee-1 fuel and 0.138 microns for Dresden-1 fuel. Filtration was shown unsuitable for clarification of LWR fuel solutions. Conventional filtration with filter aid would unacceptably complicate remote canyon operation and maintenance, might introduce dissolved silica from filter aids, and might irreversibly plug the filter with dissolver solids. Inertial filtration exhibited irreversible pluggage with nonradioactive stand-in suspensions under all conditions tested

Optimization of the Clarification System for Raw Water from the Pakra Reservoir Lake

Directory of Open Access Journals (Sweden)

Zečević, N.

2011-10-01

Full Text Available The first step in processing raw water from the Pakra lake for use in fertilizer production at Petrokemija is oxidation of total organic carbon matter with gaseous chlorine, Cl2. Thereupon it is clarified and filtered with the help of a clarification reactor and sand filters. Construction of the clarification reactor and process sand filters enables only the removal of the suspended matter from the raw water, without affecting its overall hardness. Process control of the clarification reactor and removal of the suspended matter from the raw water is achieved by adding corresponding mass concentration water solutions of aluminum sulphate, Al2(SO43 · 18 H2O and organic polyelectrolyte. The effectiveness of flocculation is carried out by laboratory determination of the m-alkalinity difference between inlet and outlet of raw water from the clarification reactor. For the most effective clarification of raw water, the optimal empirical value of the m-alkalinity difference is 0.65 mmol L-1 in the pH range of raw water from 7.0 to 8.0. Prior to processing clarified water by ionic decarbonatisation and demineralisation for protection of the ionic exchange resin from excess free Cl2, a corresponding mass concentration of a sodium bisulfite water solution, NaHSO3, is added. An improved system is proposed for continuous measurement of mass concentrations of free Cl2 in raw and clarified water, and pH difference value at the inlet and outlet of the clarification reactor. The proposed system can achieve optimal dosage of gaseous Cl2 in the raw water, improving the clarification process in the reactor as well as optimal dosage of water solution of NaHSO3. It is shown that the average pH difference from 0.65 to 0.75 at the inlet and outlet of the clarification reactor in the pH range of the raw water from 7.0 to 8.0 is an equally effective replacement for the laboratory determination of m-alkalinity. Also shown is the connection between dosage mass of the

Process cost and facility considerations in the selection of primary cell culture clarification technology.

Science.gov (United States)

Felo, Michael; Christensen, Brandon; Higgins, John

2013-01-01

The bioreactor volume delineating the selection of primary clarification technology is not always easily defined. Development of a commercial scale process for the manufacture of therapeutic proteins requires scale-up from a few liters to thousands of liters. While the separation techniques used for protein purification are largely conserved across scales, the separation techniques for primary cell culture clarification vary with scale. Process models were developed to compare monoclonal antibody production costs using two cell culture clarification technologies. One process model was created for cell culture clarification by disc stack centrifugation with depth filtration. A second process model was created for clarification by multi-stage depth filtration. Analyses were performed to examine the influence of bioreactor volume, product titer, depth filter capacity, and facility utilization on overall operating costs. At bioreactor volumes 5,000 L, clarification using centrifugation followed by depth filtration offers significant cost savings. For bioreactor volumes of ∼ 2,000 L, clarification costs are similar between depth filtration and centrifugation. At this scale, factors including facility utilization, available capital, ease of process development, implementation timelines, and process performance characterization play an important role in clarification technology selection. In the case study presented, a multi-product facility selected multi-stage depth filtration for cell culture clarification at the 500 and 2,000 L scales of operation. Facility implementation timelines, process development activities, equipment commissioning and validation, scale-up effects, and process robustness are examined. © 2013 American Institute of Chemical Engineers.

Values Clarification: Your Job or Mine?

Science.gov (United States)

McGough, Kris

1977-01-01

The author criticizes values clarification techniques done without parental consent in non-elective courses because they invade privacy, lead to ethical relativism, and have the potential to damage children's ego-strength. (Author/AV)

Towards a Kieselguhr- and PVPP-Free Clarification and Stabilization Process of Rough Beer at Room-Temperature Conditions.

Science.gov (United States)

Cimini, Alessio; Moresi, Mauro

2018-01-01

In this work, the main constraint (that is, beer chilling and chill haze removing) of the current beer conditioning techniques using Kieselguhr filtration and Polyvinylpolypyrrolidone (PVPP) treatment was overcome by developing a novel higher-throughput conditioning process, operating at room temperatures with no use of filter aids. The effect of filtration temperature (T F ) in the range of 0 to 40 °C on the hydraulic permeability of ceramic hollow-fiber (HF) membranes with nominal pore size of 0.2 to 1.4 μm, as well as on their limiting permeation flux (J * ) when feeding precentrifuged rough beer, was preliminarily assessed. When using the 1.4-μm HF membrane operating at T F ≥ 20 °C, it was possible to enhance the average permeation flux at values (676 to 1844 L/m 2 /h), noticeably higher than those (250 to 500 L/m 2 /h) characteristics of conventional powder filtration. Despite its acceptable permanent haze, the resulting beer permeate still exhibited colloidal instability. By resorting to the commercial enzyme preparation Brewers Clarex® before beer clarification, it was possible to significantly improve its colloidal stability as measured using a number of European Brewing Convention forcing tests, especially with respect to that of precentrifuged rough beer by itself. By combining the above enzymatic treatment with membrane clarification at 30 °C across the ceramic 1.4-μm HF membrane module, it was possible to limit the haze development due to chilling, sensitive proteins, and alcohol addition to as low as 0.78, 4.1, and 4.0 EBC-U, respectively, the enzymatic treatment being by far more effective than that using PVPP. A novel Kieselguhr- and PVPP-free rough beer conditioning process at room temperatures was set up. By submitting precentrifuged rough beer to commercial preparation Brewers Clarex ® and then to membrane clarification at 30 °C across a ceramic 1.4-μm hollow-fiber membrane module, it was possible to obtain a clear and stable beer with

42 CFR 84.100 - Man tests 1, 2, 3, and 4; requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Man tests 1, 2, 3, and 4; requirements. 84.100 Section 84.100 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing Apparatus § 84.100 Man tests 1...

Recombinant human parathyroid hormone related protein 1-34 and 1-84 and their roles in osteoporosis treatment.

Directory of Open Access Journals (Sweden)

Hua Wang

Full Text Available Osteoporosis is a common disorder characterized by compromised bone strength that predisposes patients to increased fracture risk. Parathyroid hormone related protein (PTHrP is one of the candidates for clinical osteoporosis treatment. In this study, GST Gene Fusion System was used to express recombinant human PTHrP (hPTHrP 1-34 and 1-84. To determine whether the recombinant hPTHrP1-34 and 1-84 can enhance renal calcium reabsorption and promote bone formation, we examined effects of recombinant hPTHrP1-34 and 1-84 on osteogenic lineage commitment in a primary bone marrow cell culture system and on osteoporosis treatment. Results revealed that both of recombinant hPTHrP1-34 and 1-84 increased colony formation and osteogenic cell differentiation and mineralization in vitro; however, the effect of recombinant hPTHrP1-84 is a little stronger than that of hPTHrP1-34. Next, ovariectomy was used to construct osteoporosis animal model (OVX to test activities of these two recombinants in vivo. HPTHrP1-84 administration elevated serum calcium by up-regulating the expression of renal calcium transporters, which resulted in stimulation of osteoblastic bone formation. These factors contributed to augmented bone mass in hPTHrP1-84 treated OVX mice but did not affect bone resorption. There was no obvious bone mass alteration in hPTHrP1-34 treated OVX mice, which may be, at least partly, associated with shorter half-life of hPTHrP1-34 compared to hPTHrP1-84 in vivo. This study implies that recombinant hPTHrP1-84 is more effective than hPTHrP1-34 to enhance renal calcium reabsorption and to stimulate bone formation in vivo.

Effect of magnetic starch on the clarification of hematite tailings wastewater

Science.gov (United States)

Yue, Tao; Wu, Xiqing

2018-02-01

The magnetic starch solution, synthesized by mixing the caustic starch, the Fe2+ solution (in some cases containing the Zn2+, Cu2+, Mn2+ or Mg2+ ions) and H2O2 solution, was used as the flocculant to investigate its clarification effect on hematite tailings wastewater. Based on the clarification tests and adsorption analysis it was demonstrated that the magnetic starch produced better clarification effect than the caustic starch, and the adsorption of magnetic starch onto hematite tailings particles was also stronger than the caustic starch. AFM found that the magnetic interaction between magnetic seeds and hematite is characteristic of long range force and greatly strengthens the adsorption of magnetic seeds onto fine hematite for agglomeration. FTIR indicates the starch adsorbed onto the surfaces of hematite and magnetic seeds, thus acting as the bridging between hematite particles and magnetic seeds, resulting in an intensified coverage of the starch onto hematite and positive action in the clarification.

77 FR 77063 - List of Correspondence From April 1, 2012, Through June 30, 2012

Science.gov (United States)

2012-12-31

... parents in private schools when free appropriate public education (FAPE) is at issue and clarification of... DEPARTMENT OF EDUCATION List of Correspondence From April 1, 2012, Through June 30, 2012 AGENCY: Office of Special Education and Rehabilitative Services; Department of Education. ACTION: Notice. SUMMARY...

Study of virgin olive oil clarification by settling under dynamic conditions.

Science.gov (United States)

Gila, Abraham; Bejaoui, Mohamed Aymen; Beltrán, Gabriel; Aguilera, María Paz; Jiménez, Antonio

2018-04-16

Vertical centrifugation is the main method for virgin olive oil (VOO) clarification. However, in recent years, settling tanks are also being used to clarify the oils from decanters. They can operate under static or dynamic conditions. In this work, vertical centrifugation and settling under dynamic conditions for VOO clarification and their effects on VOO characteristics were compared. VOO quality parameters were not affected by the clarification systems studied. The vertical centrifugal separator (VCS) showed higher clarification efficiency, giving clarified oils with higher phenol content and better sensory characteristics. VOOs clarified by dynamic settling showed notable losses of phenols and worse sensory characteristics, since the tank purge system was not efficient, with most of the impurities remaining in the tanks. The VCS with minimal water addition is a quick operation with low water consumption and is a better option to produce VOOs of improved quality, especially in terms of longer shelf life and preservation of positive sensory notes. © 2018 Society of Chemical Industry. © 2018 Society of Chemical Industry.

Clarification of vaccines: An overview of filter based technology trends and best practices.

Science.gov (United States)

Besnard, Lise; Fabre, Virginie; Fettig, Michael; Gousseinov, Elina; Kawakami, Yasuhiro; Laroudie, Nicolas; Scanlan, Claire; Pattnaik, Priyabrata

2016-01-01

Vaccines are derived from a variety of sources including tissue extracts, bacterial cells, virus particles, recombinant mammalian, yeast and insect cell produced proteins and nucleic acids. The most common method of vaccine production is based on an initial fermentation process followed by purification. Production of vaccines is a complex process involving many different steps and processes. Selection of the appropriate purification method is critical to achieving desired purity of the final product. Clarification of vaccines is a critical step that strongly impacts product recovery and subsequent downstream purification. There are several technologies that can be applied for vaccine clarification. Selection of a harvesting method and equipment depends on the type of cells, product being harvested, and properties of the process fluids. These techniques include membrane filtration (microfiltration, tangential-flow filtration), centrifugation, and depth filtration (normal flow filtration). Historically vaccine harvest clarification was usually achieved by centrifugation followed by depth filtration. Recently membrane based technologies have gained prominence in vaccine clarification. The increasing use of single-use technologies in upstream processes necessitated a shift in harvest strategies. This review offers a comprehensive view on different membrane based technologies and their application in vaccine clarification, outlines the challenges involved and presents the current state of best practices in the clarification of vaccines. Copyright © 2015 Elsevier Inc. All rights reserved.

78 FR 20901 - Combined Notice of Filings #1

Science.gov (United States)

2013-04-08

... Marketing Inc. submits Category Seller Clarification to be effective 3/29/2013. Filed Date: 3/29/13... submits Cost- Based Tariffs Compliance Filing to be effective 4/1/2013. Filed Date: 3/29/13. Accession... to be effective N/A. Filed Date: 3/29/13. Accession Number: 20130329-5223. Comments Due: 5 p.m. ET 4...

A Critique of Values: Clarification in Drug Education.

Science.gov (United States)

Chng, Chwee Lye

1980-01-01

Values clarification is widely used in drug education programs. Criticisms are offered on the role of content in valuing, the position of ethical relativism, the danger of indoctrination, and the social pressure to conform. (Author)

Effects of goal clarification on impulsivity and academic procrastination of college students

OpenAIRE

Juan F. Muñoz-Olano; Camilo Hurtado-Parrado

2017-01-01

Nearly 50% of the college population struggles with academic procrastination, which is an impulsivity problem that often leads to emotional difficulties and college dropout. This study aimed to assess whether an online intervention on clarification of academic goals could reduce impulsivity and academic procrastination in college students. Forty-eight participants were assigned to three different types of interventions: (a) SMART-type goal clarification treatment (setting specific, measurable...

78 FR 35335 - Self-Regulatory Organizations; ICE Clear Europe Limited; Notice of Filing of Amendment No. 2 to...

Science.gov (United States)

2013-06-12

.... securities, add additional clarification surrounding the operation of the combined F&O Guaranty Fund and the... Notice, ICE Clear Europe's clearing operations with respect to the LIFFE securities products, and... of securities and funds in the custody or control of ICE Clear Europe, and the protection of...

AN OPEN-LABEL EXTENSION STUDY OF PARATHYROID HORMONE RHPTH(1-84) IN ADULTS WITH HYPOPARATHYROIDISM.

Science.gov (United States)

Lakatos, Peter; Bajnok, Laszlo; Lagast, Hjalmar; Valkusz, Zsuzsanna

2016-05-01

Hypoparathyroidism is characterized by inadequate parathyroid hormone (PTH), resulting in hypocalcemia, hyperphosphatemia, and bone abnormalities. Adults with hypoparathyroidism treated with recombinant human PTH, rhPTH(1-84), in the 24-week, phase III REPLACE study maintained serum calcium despite reductions in oral calcium and active vitamin D. This study assessed the long-term efficacy and safety of rhPTH(1-84) for hypoparathyroidism. This was a 24-week, open-label, flexible-dose extension study of REPLACE (REPEAT) conducted in 3 outpatient centers in Hungary. Patients who previously completed or enrolled in REPLACE received 50 μg/day rhPTH(1-84), escalated to 75 and then to 100 μg/day, if needed, to reduce active vitamin D and oral calcium. The primary endpoint was ≥50% reduction in oral calcium (or ≤500 mg/day) and active vitamin D (or calcitriol ≤0.25 μg/day or alfacalcidol ≤0.50 μg/day) with normocalcemia. Twenty-four patients (n = 16 previously treated with rhPTH[1-84]; n = 8 rhPTH[1-84]-naïve) were enrolled and completed the study. At Week 24, 75% of patients (95% confidence interval [CI], 53.3-90.2%) achieved the study endpoint; 58% eliminated oral calcium and active vitamin D. Urinary calcium, serum phosphate, and calcium × phosphate (Ca × P) product decreased by Week 24. Mean serum bone turnover markers increased with rhPTH(1-84). Treatment-emergent adverse events (TEAEs) were reported by 92% of patients. No serious adverse events (AEs) occurred. This study used a simplified treatment algorithm intended to better mimic typical clinical practice and demonstrated the extended efficacy and safety of rhPTH(1-84) in patients with hypoparathyroidism and confirmed the REPLACE findings. Sustained rhPTH(1-84) efficacy up to 48 weeks was observed despite treatment interruption between studies.

A Conversation-Analytic Perspective on the Organization of Teacher-Led Clarification and Its Implications for L2 Teacher Training

Science.gov (United States)

Atar, Cihat; Seedhouse, Paul

2018-01-01

This study analyses teacher-led clarification sequences in a university second language classroom setting from a conversation-analytic perspective. In the literature, there are many studies of clarification requests, but the focus is on individual categories and quantification. No previous study has examined clarification, as reconceptualised in…

Optimization of enzymatic clarification of green asparagus juice using response surface methodology.

Science.gov (United States)

Chen, Xuehong; Xu, Feng; Qin, Weidong; Ma, Lihua; Zheng, Yonghua

2012-06-01

Enzymatic clarification conditions for green asparagus juice were optimized by using response surface methodology (RSM). The asparagus juice was treated with pectinase at different temperatures (35 °C-45 °C), pH values (4.00-5.00), and enzyme concentrations (0.6-1.8 v/v%). The effects of enzymatic treatment on juice clarity and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging capacity were investigated by employing a 3-factor central composite design coupled with RSM. According to response surface analysis, the optimal enzymatic treatment condition was pectinase concentration of 1.45%, incubation temperature of 40.56 °C and pH of 4.43. The clarity, juice yield, and soluble solid contents in asparagus juice were significantly increased by enzymatic treatment at the optimal conditions. DPPH radical-scavenging capacity was maintained at the level close to that of raw asparagus juice. These results indicated that enzymatic treatment could be a useful technique for producing green asparagus juice with high clarity and high-antioxidant activity. Treatment with 1.45% pectinase at 40.56 ° C, pH 4.43, significantly increased the clarity and yield of asparagus juice. In addition, enzymatic treatment maintained antioxidant activity. Thus, enzymatic treatment has the potential for industrial asparagus juice clarification. © 2012 Institute of Food Technologists®

Influence of prefermentary clarification on the composition of apple musts.

Science.gov (United States)

Hubert, Bertrand; Baron, Alain; Le Quere, Jean-Michel; Renard, Catherine M G C

2007-06-27

The polyphenol contents and colors of cider apple juices were compared before (NCM, not clarified must) and after five clarification treatments: enzymatic depectinization by pectinases followed by (i) sedimentation (depectinized and decanted juice), (ii) tangential microfiltration (microfiltered juice) or (iii) fining using gelatin (gelatin-treated juice); (iv) enzymatic gelification of pectin by pectin methylesterase followed by natural keeving by a cider manufacturer (producer keeved juice), or (v) flotation (floated with nitrogen gas juice). The pressing of the apples led to the highly selective extraction of the flavan-3-ols with the lowest molecular weights: In the apples, the number average degree of polymerization of the flavanols was 14.7, and it dropped to 2.2 in the NCM. Keeving had the highest impact on the reduction of both flavanol content and number average degree of polymerization. The flavanol concentrations were decreased in the permeate by fining (30%) much more than by depectinization. The clarification step led to a further decrease of the number average degree of polymerization. Hydroxycinnamic acids were less affected by the extraction process (with extraction yields >50%) and not affected by clarification. The color evolved with all treatments: L*, a*, b*, and chromaticity distance index measures indicated a reduction of orange-yellow saturation except after sedimentation.

78 FR 54517 - Water Quality Standards Regulatory Clarifications

Science.gov (United States)

2013-09-04

... 131 Water Quality Standards Regulatory Clarifications; Proposed Rule #0;#0;Federal Register / Vol. 78... AGENCY 40 CFR Part 131 [EPA-HQ-OW-2010-0606; FRL-9839-7] RIN 2040-AF 16 Water Quality Standards... Environmental Protection Agency (EPA) is proposing changes to the federal water quality standards (WQS...

GPR84 and TREM-1 signaling contribute to the pathogenesis of reflux esophagitis.

Science.gov (United States)

Abdel-Aziz, Heba; Schneider, Mathias; Neuhuber, Winfried; Kassem, Abdel Meguid; Khailah, Saleem; Müller, Jürgen; Gamaleldeen, Hadeel; Khairy, Ahmed; Khayyal, Mohamed T; Shcherbakova, Anastasiia; Efferth, Thomas; Ulrich-Merzenich, Gudrun

2015-11-24

Gastro-esophageal reflux disease (GERD) is one of the most common disorders in gastroenterology. Patients present with or without increased acid exposure indicating a non-uniform etiology. Thus the common treatment with proton pump inhibitors (PPIs) fails to control symptoms in up to 40% of patients.To further elucidate the pathophysiology of the condition and explore new treatment targets, transcriptomics, proteomics and histological methods were applied to a surgically induced sub-chronic reflux esophagitis model in Wistar rats after treatment with either omeprazole (PPI) or STW5, a herbal preparation shown to ameliorate esophagitis without affecting refluxate pH. The normal human esophageal squamous cellline HET-1A and human endoscopic biopsies were used to confirm our findings to the G-protein coupled receptor (GPR) 84 in human tissue.Both treatments reduced reflux-induced macroscopic and microscopic lesions of the esophagi as well as known pro-inflammatory cytokines. Proteomic and transcriptomic analyses identified CINC1-3, MIP-1/3α, MIG, RANTES and IL-1β as prominent mediators in GERD. Most regulated cyto-/chemokines are linked to the TREM-1 signaling pathway. The fatty acid receptor GPR84 was up-regulated in esophagitis but significantly decreased in treated groups, a finding supported by Western blot and immunohistochemistry in both rat tissue and HET-1A cells. GPR84 was also found to be significantly up-regulated in patients with grade B reflux esophagitis.The expression of GPR84 in esophageal tissue and its potential involvement in GERD are reported for the first time. IL-8 (CINC1-3) and the TREM-1 signaling pathway are proposed, besides GPR84, to play an important role in the pathogenesis of GERD.

76 FR 35922 - Notice of Issuance of Regulatory Guide

Science.gov (United States)

2011-06-20

.... Proposed Revision 1 of Regulatory Guide (RG) 8.4, ``Personnel Monitoring Device--Direct-Reading Pocket...'' at http://www.nrc.gov/reading-rm/doc-collections/ . In addition, regulatory guides are available for... NUCLEAR REGULATORY COMMISSION [NRC-2010-0148] Notice of Issuance of Regulatory Guide AGENCY...

21 CFR 1.90 - Notice of sampling.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Notice of sampling. 1.90 Section 1.90 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GENERAL ENFORCEMENT REGULATIONS Imports and Exports § 1.90 Notice of sampling. When a sample of an article offered for import has...

Experimental data and theoretical predictions for the rate of electrophoretic clarification of colloidal suspensions

Energy Technology Data Exchange (ETDEWEB)

Johnson, T.J.; Davis, E.J.

2000-05-01

An experimental and theoretical investigation of the electrophoretic clarification rate of colloidal suspensions was conducted. The suspensions included a coal-washing effluent and a model system of TiO{sub 2} particles. A parametric study of TiO{sub 2} suspensions was performed to validate and analysis of the electrophoretic motion of the clarification front formed between a clear zone and the suspension. To measure the electric field strength needed in the prediction of the location of the front, a moveable probe and salt bridge were connected to a reference electrode. Using the measured electric field strengths, it was found that the numerical solution to the unit cell electrophoresis model agrees with the measured clarification rates. For suspensions with moderately thick electric double layers and high particle volume fractions the deviations from classical Smoluchowski theory are substantial, and the numerical analysis is in somewhat better agreement with the data than a prior solution of the problem. The numerical model reduces to the predictions of previous theories as the thickness of the electric double layer decreases, and it is in good agreement with the clarification rate measured for a coal-washing effluent suspension with thin electric double layers.

Structural, thermal and optical behavior of 84 MeV oxygen and 120 MeV silicon ions irradiated PES

International Nuclear Information System (INIS)

Samra, Kawaljeet Singh; Thakur, Sonika; Singh, Lakhwant

2011-01-01

In order to study structural, thermal and optical behavior, thin flat samples of polyethersulfone were irradiated with oxygen and silicon ions. The changes in properties were analyzed using different techniques viz: X-ray diffraction, thermo-gravimetric analysis, Fourier transform infrared, UV-visible and photoluminescence spectroscopy. A noticeable increase in the intensity of X-ray diffraction peaks was observed after irradiation with 84 MeV oxygen ions at low and medium fluences, which may be attributed to radiation-induced cross-linking in polymer. Fourier transform infrared and thermo-gravimetric analysis corroborated the results of X-ray diffraction analysis. No noticeable change in the Fourier transform infrared spectra of oxygen ion irradiated polyethersulfone were observed even at the highest fluence of 1 x 10 13 ions cm -2 , but after irradiation with silicon ions, a reduction in intensity of almost all characteristic bands was revealed. An increase in the activation energy of decomposition of polyethersulfone was observed after irradiation with 84 MeV oxygen ions up to medium fluences but degradation was revealed at higher fluences. Similar trends were observed by photoluminescence analysis.

MUCILAGINOUS PLANTS IN THE CLARIFICATION OF SUGAR CANE JUICE

Directory of Open Access Journals (Sweden)

Walter Francisco Quezada Moreno

2016-04-01

Full Text Available The aim is to incorporate mucilaginous solutions in the juice clarification process as an alternative for improving the final products that are produced in the agribusiness panela in Ecuador. The study was conducted with 14 mucilaginous plants properties, five plant species: Mallow wild (Malva peruviana L., Yausabara (Pavonia sepium A. St-Hil Yausa (Abutilon famous Planch, black Cadillo (Triumfetta Lappula L and False Joaquín (Hibiscus rosa-sinensis, it was obtained excellent results as clarifying agents. Three factors were assayed experimentally such as solution concentration, amount of solution added to the juice and incorporation temperature on two levels, judged by turbidity variable as a response. The results indicated that the factors tested affect significantly the juice clarification (clear and bright and the best results were achieved with turbidity (Yausabara and Yausa Malva silvestre, Falso Joaquín y Cadillo negro and with the combinations obtaining juices.

34 CFR 84.640 - Employee.

Science.gov (United States)

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Employee. 84.640 Section 84.640 Education Office of the...) Definitions § 84.640 Employee. (a) Employee means the employee of a recipient directly engaged in the performance of work under the award, including— (1) All direct charge employees; (2) All indirect charge...

Relations between must clarification and organoleptic attributes of wine varietes

Directory of Open Access Journals (Sweden)

Vladimír Vietoris

2014-02-01

Full Text Available Blowdown musts is important operation performed in winemaking, which can have a major impact on the future quality of the wine. Blowdown of the wine removes components that may carry elements that negatively affect the hygienic and sensory quality of the wine. Fining of musts and wines is carried either by a static method or using different fining preparations. The aim of this work was to evaluate the effect of different methods of decanting on the wine quality varieties of Sauvignon. The overall sensory quality was evaluated (100 - points system, and semantic differential and the aromatic profile (profile method. All sensory evaluations were practiced by skilled sensory panel in controled conditions of Faculty sensory lab. Wine samples were clarified by static manner or with the assistance of the preparation applied to the clarification of wine in two different doses. By the results and their visualization of flavour and smell profile by spider plots we could conclude that pure cultures have positive effect on processed wine. Based on the results we found a beneficial effect of clearing by the clarification of the preparation based on cellulose, polyvinylpolypyrrolidone, gelatin and mineral adsorbents at 100 g.100 L-1  of the sensory quality of the wine.

77 FR 43585 - Combined Notice of Filings #1

Science.gov (United States)

2012-07-25

...-000. Applicants: Mehoopany Wind Energy LLC. Description: Notice of Self-Certification of Exempt Wholesale Generator Status of Mehoopany Wind Energy LLC. Filed Date: 7/17/12. Accession Number: 20120717... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...

26 CFR 301.6155-1 - Payment on notice and demand.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Payment on notice and demand. 301.6155-1... for Payment of Tax § 301.6155-1 Payment on notice and demand. Upon receipt of notice and demand from...) stated in such notice and demand. ...

76 FR 41785 - Combined Notice of Filings #1

Science.gov (United States)

2011-07-15

..., Doswell Limited Partnership, FPL Energy Cape, LLC, FPL Energy Illinois Wind, LLC, FPL Energy Maine Hydro... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... on Friday, July 22, 2011. Take notice that the Commission received the following electric rate...

Experimental data and theoretical predictions of the rate of electrophoretic clarification of colloidal suspensions

Energy Technology Data Exchange (ETDEWEB)

Johnson, T.J.; Davis, E.J. [University of Washington, Seattle, WA (USA). Dept. of Chemical Engineering

2000-05-01

An experimental and theoretical investigation of the electrophoretic clarification rate of colloidal suspensions was conducted. The suspensions included a coal-washing effluent and a model system of TiO{sub 2} particles. A parametric study of TiO{sub 2} suspensions was performed to validate an analysis of the electrophoretic motion of the clarification front formed between a clear zone and the suspension. To measure the electric field strength needed in the prediction of the location of the front, a moveable probe and salt bridge were connected to a reference electrode. Using the measured electric field strength, it was found that the numerical solution to the unit cell electrophoresis model agrees with the measured clarification rates. For suspensions with moderately thick electric double layers and high particle volume fractions the deviations from classical Smoluchowski theory are substantial, and the numerical analysis is in somewhat better agreement with the data than a prior solution of the problem. The numerical model reduces to the predictions of previous theories as the thickness of the electric double layer decreases, and it is in good agreement with the clarification rate measured for a coal-washing effluent suspension with thin electric double layers. 21 refs., 8 figs., 4 tabs.

16 CFR 1.84 - Draft environmental impact statements: Availability and comment.

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Draft environmental impact statements... Environmental Policy Act of 1969 § 1.84 Draft environmental impact statements: Availability and comment. Except for proposals for legislation, environmental impact statements shall be prepared in two stages: Draft...

77 FR 15747 - Combined Notice of Filings #1

Science.gov (United States)

2012-03-16

... Wholesale Generator Status of Magic Valley Wind Farm I, LLC. Filed Date: 3/7/12. Accession Number: 20120307..., LLC. Description: Notice of Self-Certification of Exempt Wholesale Generator Status of Wildcat Wind... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...

78 FR 25261 - Combined Notice of Filings #1

Science.gov (United States)

2013-04-30

...- 004; ER12-2496-004. Applicants: Bangor Hydro Electric Company, Emera Energy Services, Inc., Emera.... Description: Notice of Change in Status of Bangor Hydro Electric Company, et al. Filed Date: 4/22/13... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...

28 CFR 513.12 - Inmate request for record clarification.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Inmate request for record clarification. 513.12 Section 513.12 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE GENERAL MANAGEMENT AND ADMINISTRATION ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.12...

Polyelectrolyte flocculation of grain stillage for improved clarification and water recovery within bioethanol production facilities.

Science.gov (United States)

Menkhaus, Todd J; Anderson, Jason; Lane, Samuel; Waddell, Evan

2010-04-01

Polyelectrolytes were investigated for flocculation of a corn whole stillage stream to improve solid-liquid clarification operations and reduce downstream utility requirements for evaporation and drying within a bioethanol process. Despite a negative zeta potential for the stillage solids, an anionic polyelectrolyte was found to provide the best flocculation. At the optimal dosage of 1.1mg polymer/g dry suspended solids, an anionic flocculant provided a clarified stream with only 0.15% w/w suspended solids (equivalent to a total dissolved solid to total suspended solid ratio greater than 40, and a viscosity reduction of 39% compared to an unflocculated "clarified" stream). The resulting solids cake had greater than 40% w/w solids, and more than 80% water recovery was found in the clarified stream. Addition of flocculant improved filtration flux by six fold and/or would allow for up to a 4-times higher flow rate if using a decanting centrifuge for clarification of corn stillage. Copyright 2009 Elsevier Ltd. All rights reserved.

78 FR 19475 - Combined Notice of Filings #1

Science.gov (United States)

2013-04-01

... Wholesale Generator Status of Alta Wind X, LLC. Filed Date: 3/21/13. Accession Number: 20130321-5127...: Notice of Self-Certification of Exempt Wholesale Generator Status of Alta Wind XI, LLC. Filed Date: 3/21... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...

26 CFR 1.6036-1 - Notice of qualification as executor or receiver.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Notice of qualification as executor or receiver. 1.6036-1 Section 1.6036-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... executor or receiver. For provisions relating to the notice required of fiduciaries, see the regulations...

78 FR 69407 - Combined Notice of Filings #1

Science.gov (United States)

2013-11-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric corporate filings: Docket Numbers: EC14-24-000... of Eldorado Co-Tenancy and Communication Agreement to be effective 1/1/2014. Filed Date: 11/7/13...

[The replacement therapy of rPTH(1-84) in established rat model of hypothyroidism].

Science.gov (United States)

Ding, Zhiwei; Li, Tiancheng; Liu, Yuhe; Xiao, Shuifang

2015-12-01

To investigate the replacement therapy of rPTH(1-84) (recombinant human parathyroid hormone (1-84)) to hypothyroidism in established rat model. Rat model of hypothyroidism was established by resecting parathyroids. A total of 30 rats with removal of parathyroids were divided into 6 groups randomly, 5 in each group, and applied respectively with saline injection (negative control group), calcitriol treatment (positive control group) and quadripartite PTH administration with dose of 20, 40, 80 and 160 µg/kg (experimental groups). Saline and rPTH(1-84) were injected subcutaneously daily. Calcitriol was gavaged once a day. Sham-operation was conducted in 5 rats of negative control group. To verify the authenticity of the rat model with hypothyroidism, the serum was insolated centrifugally from rat blood that was obtained from angular vein at specific time to measure calcium and phosphorus concentration. Urine in 12 hours was collected by metabolic cages and the calcium concentration was measured. After 10-week drug treatment, the experiment was terminated and bilateral femoral bone and L2-5 lumbar vertebra were removed from rats. Bone mineral density (BMD)of bilateral femoral bone and lumbar vertebra was analyzed by dual X-ray absorptiometry (DXA). The concentration of bone alkaline phosphatase (BALP) in serum was determined by radioimmunoassay. The rat model with hypothyroidism was obtained by excising parathyroid gland and was verified by monitoring calcium and phosphorus concentration subsequently. Administration of rPTH(1-84) in the dose of 80 or 160 µg/kg made serum calcium and phosphorus back to normal levels, with no significant difference between the doses (P>0.05). The BMD in each group of rats with rPTH(1-84) administration was increased significantly (P0.05). Calcium and phosphorus return to normal level by administration of rPTH(1-84) in the dose of 80 µg/kg or 160 µg/kg, with increase in BMD. Calcitriol can return the level of calcium to normal and

Acid activation of upper Eocene Ca-bentonite for soybean oil clarification.

Science.gov (United States)

Chakroun, Salima; Herchi, Mongi; Mechti, Wafa; Gaied, Mohamed Essghaier

2017-10-01

In central Tunisia, many upper Eocene outcrops supply smectitic claystone which are characterized by several analytical techniques (calcimetry, XRD, SediGraph, chemical analysis, surface area, etc.). Beidellite is the main mineral detected by the XRD method. Representative raw samples M1, taken from Henchir Souar (Zaghouan, Tunisia), were acid activated in order to improve their physicochemical properties. This study consists in optimizing the activation conditions with HCl 3 N by varying the following parameters: time (2, 4, and 6 h) and temperature (25, 50, 75, and 90 °C). The characterization by XRD and chemical analysis was carried out on the samples (M1, activated for 2 and 6 h at 75 °C), showing a structural modification of the clay by reduction of intensity reflection 001 order of smectite and dissolution of metal ions (Al 3+ , Fe 3+ , and Mg 2+ ) from clay structure. Optimum condition for soybean oil clarification is obtained using a variety of amount raw clays (0.5, 0.75, and 1%). Thus, the best clarification yield is given at 0.75% of clay, showing a capacity of about 55%. Various forms of activated materials were used with a 75% proportion to leach soybean oil. Results were compared with commercial bentonite (Tonsil) having surface area (378 m 2 /g). The activated sample M1 during 4 h at 75 °C possesses a decolorizing capacity of about 85% greater than the oil treated by Tonsil in laboratory (58%).

78 FR 6815 - Combined Notice of Filings #1

Science.gov (United States)

2013-01-31

.... Applicants: Bangor Hydro Electric Company, Emera Energy U.S. Subsidiary No. 1, Inc, Emera Energy U.S... Status of Bangor Hydro Electric Company, et al. Filed Date: 1/22/13. Accession Number: 20130122-5373... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...

29 CFR 1902.12 - Opportunity for modifications and clarifications.

Science.gov (United States)

2010-07-01

... 29 Labor 5 2010-07-01 2010-07-01 false Opportunity for modifications and clarifications. 1902.12 Section 1902.12 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR STATE PLANS FOR THE DEVELOPMENT AND ENFORCEMENT OF STATE STANDARDS Procedures for Submission, Approval and Rejection of...

75 FR 70248 - Endocrine Disruptor Screening Program; Second List of Chemicals for Tier 1 Screening

Science.gov (United States)

2010-11-17

... 1457. Today's publication provides public notice of EPA's tentative decision-making in advance of the... difficulties and cannot contact you for clarification, EPA may not be able to consider your comment. Electronic... women, the elderly, [[Page 70251

42 CFR 84.256 - Quality control requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Quality control requirements. 84.256 Section 84.256... § 84.256 Quality control requirements. (a) In addition to the construction and performance requirements specified in §§ 84.251, 84.252, 84.253, 84.254, and 84.255, the quality control requirements in paragraphs...

Effects of 1.84 GHz radio-frequency electromagnetic field on sperm ...

African Journals Online (AJOL)

sunny t

Key words: 1.84 GHz, radio-frequency electromagnetic field (RF-EMF), epididymis, ... Author(s) agree that this article remains permanently open access under the terms of the ..... mouse testis after the long-term administration of nickel in feed.

34 CFR 84.655 - Individual.

Science.gov (United States)

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Individual. 84.655 Section 84.655 Education Office of the Secretary, Department of Education GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 84.655 Individual. Individual means a natural person. (Authority: E.O.s 12549 and...

45 CFR 84.45 - Housing.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Housing. 84.45 Section 84.45 Public Welfare... PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Postsecondary Education § 84.45 Housing. (a) Housing provided by the recipient. A recipient that provides housing to its nonhandicapped students shall...

Comparison between microfiltration and addition of coagulating agents in the clarification of sugar cane juice - doi: 10.4025/actascitechnol.v34i4.8890

Directory of Open Access Journals (Sweden)

Rosa Maria Cripa Moreno

2012-10-01

Full Text Available This study accomplished a comparison between microfiltration and addition of coagulating agents to clarify sugar cane juice. Microfiltration tests were carried out using ceramic tubular membranes made with TiO2/a-Al2O3, with pore diameter of 0.2; 0.4 and 0.6 mm. The transmembrane pressures applied were 1.0, 2.0 and 3.0 bar, and temperature was kept constant at 20ºC. Clarification test with addition of coagulating agents were performed with PAC and Ca (OH2 at 65ºC. The highest permeate flow was 76 kg h-1 m-2 at 1.0 bar with 0.6 μm-membrane. The clarification process with membranes achieved a reduction of turbidity and color superior to 92 and 16%, respectively. In the clarification by adding coagulating agents we verified a reduction superior to 78 and 46% to turbidity and color, respectively.

78 FR 28210 - Combined Notice of Filings #1

Science.gov (United States)

2013-05-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... Company of New Mexico. Description: City of Gallup Network Integration Transmission Service Agreement to..., Section III--Distribution of Revenues to be effective 7/1/2013. Filed Date: 4/30/13. Accession Number...

34 CFR 84.605 - Award.

Science.gov (United States)

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Award. 84.605 Section 84.605 Education Office of the Secretary, Department of Education GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 84.605 Award. Award means an award of financial assistance by the Department of Education or...

45 CFR 84.11 - Discrimination prohibited.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discrimination prohibited. 84.11 Section 84.11... § 84.11 Discrimination prohibited. (a) General. (1) No qualified handicapped person shall, on the basis of handicap, be subjected to discrimination in employment under any program or activity to which this...

78 FR 17391 - Combined Notice of Filings #1

Science.gov (United States)

2013-03-21

... Electric Company, Emera Energy Services, Inc., Emera Energy U.S. Subsidiary No. 1, Inc., Emera Energy U.S... in Status of Bangor Hydro Electric Company, et al. Filed Date: 3/13/13. Accession Number: 20130313... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...

78 FR 79428 - Combined Notice of Filings #1

Science.gov (United States)

2013-12-30

.... Comments Due: 5 p.m. ET 1/8/14. Docket Numbers: ER14-655-000. Applicants: Bangor Hydro Electric Company. Description: Bangor Hydro Electric Company submits Filing to Effect Succession to Rate Schedules and Service... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...

29 CFR 20.84 - Collections.

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Collections. 20.84 Section 20.84 Labor Office of the Secretary of Labor FEDERAL CLAIMS COLLECTION Salary Offset § 20.84 Collections. (a) Whenever feasible, and... 15 percent of disposable pay for an officially established pay interval, collection must be made in...

26 CFR 1.854-2 - Notice to shareholders.

Science.gov (United States)

2010-04-01

... shall, upon notice by the Internal Revenue Service that the regulated investment company has failed to... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Notice to shareholders. 1.854-2 Section 1.854-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED...

Using Task Clarification, Goal Setting, and Feedback to Decrease Table Busing Times in a Franchise Pizza Restaurant

Science.gov (United States)

Amigo, Seth; Smith, Andrew; Ludwig, Timothy

2008-01-01

The current study investigated the effects of task-clarification, and manager verbal and graphic feedback on employee busing times at a pizza restaurant. Using an ABC design, task-clarification was provided in a memo, which described the process, priority, and goal time of busing. The busing time decreased slightly, from an average of 315 seconds…

76 FR 36089 - Circular Welded Non-Alloy Steel Pipe From the Republic of Korea: Final Results of the Antidumping...

Science.gov (United States)

2011-06-21

... Tube From Brazil, the Republic of Korea, Mexico, and Venezuela, 61 FR 11608 (March 21, 1996), pipe...) (``Assessment Policy Notice''). This clarification will apply to entries of subject merchandise during the... transaction. See Assessment Policy Notice for a full discussion of this clarification. Cash Deposit...

Applying critical thinking skills to character education and values clarification with students who are deaf or hard of hearing.

Science.gov (United States)

Easterbrooks, Susan R; Scheetz, Nanci A

2004-01-01

Students who are deaf or hard of hearing must learn to think critically. Character education (CE) refers to the effort to teach basic values and moral reasoning (Doyle & Ponder, 1977). Values clarification (VC) is the process of examining one's basic values and moral reasoning (Rokeach, 1973). Character education and values clarification as subject matter foster the development of critical thinking (CT), a tool used both to develop and to modify values and moral reasoning. These three areas mutually support one another. The development of a set of values and their underlying moral reasoning is the foundation for thinking critically about values. The authors examine the components of critical thinking, character education, and values clarification, summarize the literature, and provide a template for appropriate lesson plans. They also describe strategies that promote the development of critical thinking, character education, and values clarification.

Structure of non-(1-84) PTH fragments secreted by parathyroid glands in primary and secondary hyperparathyroidism.

Science.gov (United States)

D'Amour, Pierre; Brossard, Jean-Hugues; Rousseau, Louise; Nguyen-Yamamoto, Loan; Nassif, Edgard; Lazure, Claude; Gauthier, Dany; Lavigne, Jeffrey R; Zahradnik, Richard J

2005-09-01

Non-(1-84) parathyroid hormone (PTH) fragments are large circulating carboxyl-terminal (C) fragments with a partially preserved amino-terminal (N) structure. hPTH (7-84), a synthetic surrogate, has been demonstrated to exert biologic effects in vivo and in vitro which are opposite to those of hPTH (1-34) on the PTH/PTHrP type I receptor through a C-PTH receptor. We wanted to determine the N structure of non-(1-84) PTH fragments. Parathyroid cells isolated from glands obtained at surgery from three patients with primary hyperparathyroidism and three patients with secondary hyperparathyroidism were incubated with 35S-methionine to internally label their secretion products. Incubations were performed for 8 hours at the patient-ionized calcium concentration and in the presence of various protease inhibitors. The supernatant was fractionated by high-performance liquid chromatography (HPLC) and fractions were analyzed with PTH assays having (1 to 4) and (12 to 23) epitopes, respectively. The serum of each patient was similarly analyzed. Peaks of immunoreactivity identified were submitted to sequence analysis to recover the 35S-methionine residues in positions 8 and 18. Three regions of interest were identified with PTH assays. They corresponded to non-(1-84) PTH fragments (further divided in regions 3 and 4), a peak of N-PTH migrating in front of hPTH (1-84) (region 2) and a peak of immunoreactivity corresponding to the elution position of hPTH (1-84) (region 1). The last corresponded to a single sequence starting at position 1. Region 2 gave similar results in all cases (a major signal starting at position 1) but also sometimes minor sequences starting at position 4 or 7. Regions 3 and 4 always identified a major sequence starting at positions 7 and minor sequences starting at positions 8, 10, and 15. Surprisingly, a major signal starting at position 1 was also present in region 3. The HPLC profile obtained from a given patient's parathyroid cells was qualitatively

21 CFR 814.84 - Reports.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Reports. 814.84 Section 814.84 Food and Drugs FOOD... APPROVAL OF MEDICAL DEVICES Postapproval Requirements § 814.84 Reports. (a) The holder of an approved PMA... otherwise, any periodic report shall: (1) Identify changes described in § 814.39(a) and changes required to...

34 CFR 84.665 - State.

Science.gov (United States)

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false State. 84.665 Section 84.665 Education Office of the...) Definitions § 84.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico, or any territory or possession of the United States. (Authority: E.O.s 12549 and...

78 FR 22034 - Proposed Collection; Comment Request for Notice 2001-1

Science.gov (United States)

2013-04-12

... Notice 2001-1, Employer-designed Tip Reporting Program for the Food and Beverage Industry (EmTRAC). DATES... Program for the Food and Beverage Industry (EmTRAC). OMB Number: 1545-1716. Notice Number: Notice 2001-1...

26 CFR 301.6223(b)-1 - Notice group.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Notice group. 301.6223(b)-1 Section 301.6223(b... ADMINISTRATION PROCEDURE AND ADMINISTRATION Assessment In General § 301.6223(b)-1 Notice group. (a) In general. If a group of partners having in the aggregate a 5 percent or more interest in the profits of a...

Clarification of Orange Press Liquors by PVDF Hollow Fiber Membranes

Directory of Open Access Journals (Sweden)

Silvia Simone

2016-01-01

Full Text Available Press liquors are typical by-products of the citrus juice processing characterized by a high content of organic compounds and associated problems of environmental impact, which imply high treatment costs. However, these wastes contain a great number of health promoting substances, including fibers, carotenoids and phenolic compounds (mainly flavonoids, whose recovery against waste-destruction technologies is very attractive for new business opportunities. In this work, the clarification of orange press liquor by using microfiltration (MF membranes is studied as a preliminary step to obtain a permeate stream enriched in antioxidant compounds which can be further processed to produce extracts of nutraceutical and/or pharmaceutical interest. MF poly(vinylidene fluoride (PVDF hollow fibers were prepared by the dry/wet spinning technique. A series of fibers was produced from the same polymeric dope, in order to investigate the effect of selected spinning parameters, i.e., bore fluid composition and flowrate, on their properties. The morphology of the produced fibers was analyzed by Scanning Electron Microscopy (SEM. Fibers were further characterized for their mechanical properties, porosity, bubble point, pore size distribution and pure water permeability (PWP. Some of the produced fibers exhibited high permeability (pure water permeability ~530 L/m2·h·bar, coupled to good mechanical resistance and pore size in the range of MF membranes. These fibers were selected and used for the clarification of press liquor from orange peel processing. In optimized operating conditions, the selected fibers produced steady-state fluxes of about 41 L/m2·h with rejections towards polyphenols and total antioxidant activity of 4.1% and 1.4%, respectively.

78 FR 5436 - Combined Notice of Filings #1

Science.gov (United States)

2013-01-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...: New Mexico Green Initiatives, LLC. Description: New Mexico Green Initiatives, LLC submits tariff...: Docket Numbers: QF12-174-000. Applicants: Winona County Wind, LLC. [[Page 5437

76 FR 44319 - Combined Notice of Filings #1

Science.gov (United States)

2011-07-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric corporate filings: Docket Numbers: EC11-96-000. Applicants: Dartmouth Power Associates Limited Partnership, Camden Plant Holding, LLC, Pedricktown...

Influence de colorants dissous sur le point de clarification de phases nématiques

OpenAIRE

Diot , P.; Foitzik , J.K.; Haase , W.

1985-01-01

Les systèmes « guest-host » dopés avec des colorants dichroïques sont importants pour certains types d'afficheurs. Ce travail rapporte l'influence des propriétés des colorants dissous sur le comportement de clarification. Les phases nématiques suivantes ont été choisies : CB-7, PCH-7 et ZLI-1083, un mélange eutectique ternaire de PCH-3, PCH-5 et PCH-7; quatre dérivés anthraquinoniques ont été choisis comme colorants. L'influence des colorants sur le comportement de clarification est discutée ...

78 FR 25260 - Combined Notice of Filings #1

Science.gov (United States)

2013-04-30

.... Description: Interconnection Agreement Between Massachusetts Electric Co. and Pepperell Hydro to be effective... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-3063-001...

78 FR 70297 - Combined Notice of Filings #1

Science.gov (United States)

2013-11-25

...-002. Applicants: ISO New England Inc., Bangor Hydro Electric Company, Central Maine Power Company... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric corporate filings: Docket Numbers: EC14-28-000...

77 FR 2284 - Combined Notice of Filings #1

Science.gov (United States)

2012-01-17

...: CPV Cimarron Renewable Energy Company, LLC. Description: CPV Cimarron Renewable Energy Company, LLC... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... Service Company of New Mexico. Description: Public Service Company of New Mexico submits tariff filing per...

77 FR 30536 - Final Notice Regarding Updates and Clarifications of the Implementation of the Scholarships for...

Science.gov (United States)

2012-05-23

... dental hygiene and behavioral and mental health discipline (clinical psychology, clinical social work... physical therapy); mental and behavioral health (graduate degree programs in clinical psychology, clinical... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Resources and Services Administration Final Notice...

77 FR 58121 - Combined Notice of Filings #1

Science.gov (United States)

2012-09-19

... following exempt wholesale generator filings: Docket Numbers: EG12-108-000. Applicants: Prairie Rose Wind... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice.... Applicants: NRG Energy, Inc, GenOn Energy, Inc. Description: NRG Energy, Inc et al. submits additional...

77 FR 51991 - Combined Notice of Filings #1

Science.gov (United States)

2012-08-28

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric corporate filings: Docket Numbers: EC12-135-000. Applicants: Energia Sierra Juarez U.S., LLC. Description: Section 203 Application of Energia Sierra Juarez U...

77 FR 73028 - Combined Notice of Filings #1

Science.gov (United States)

2012-12-07

.... Applicants: ISO New England Inc. & Bangor Hydro-Electric Company. Description: Bangor Hydro Electric Company... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-1790-008; ER10...

78 FR 62612 - Combined Notice of Filings #1

Science.gov (United States)

2013-10-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric corporate filings: Docket Numbers: EC14-3-000...: PE Hydro Generation, LLC Description: Self-Certification of EG of PE Hydro Generation, LLC. Filed...

Clarification of TMI action plan requirements. Requirements for emergency response capability

International Nuclear Information System (INIS)

1983-01-01

This document, Supplement 1 to NUREG-0737, is a letter from D. G. Eisenhut, Director of the Division of Licensing, NRR, to licensees of operating power reactors, applicants for operating licenses, and holders of construction permits forwarding post-TMI requirements for emergency response capability which have been approved for implementation. On October 30, 1980, the NRC staff issued NUREG-0737, which incorporated into one document all TMI-related items approved for implementation by the Commission at that time. In this NRC report, additional clarification is provided regarding Safety Parameter Display Systems, Detailed Control Room Design Reviews, Regulatory Guide 1.97 (Revision 2) - Application to Emergency Response Facilities, Upgrade of Emergency Operating Procedures, Emergency Response Facilities, and Meteorological Data

45 CFR 84.4 - Discrimination prohibited.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discrimination prohibited. 84.4 Section 84.4... § 84.4 Discrimination prohibited. (a) General. No qualified handicapped person shall, on the basis of... discrimination under any program or activity which receives Federal financial assistance. (b) Discriminatory...

76 FR 64339 - Combined Notice of Filings #1

Science.gov (United States)

2011-10-18

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER04-157-033; ER04-714-022; EL05-89-011. Applicants: Bangor Hydro-Electric Company; Florida Power & Light Company New...

78 FR 21926 - Combined Notice of Filings #1

Science.gov (United States)

2013-04-12

...., Astoria Energy LLC, Astoria Energy II LLC, Calumet Energy Team, LLC, FirstLight Hydro Generating Company... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-2669-007; ER10...

77 FR 20815 - Combined Notice of Filings #1

Science.gov (United States)

2012-04-06

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER04-157-034; ER04-714-023; EL05-89-012. Applicants: Bangor Hydro-Electric Company, Florida Power & Light Company--New...

77 FR 37397 - Combined Notice of Filings #1

Science.gov (United States)

2012-06-21

..., Emera Energy U.S. Subsidiary No. 2, Inc., Bangor Hydro Electric Company. Description: Change in Status Filing of Bangor Hydro Electric Company, et al. Filed Date: 6/13/12. Accession Number: 20120613-5023... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...

77 FR 27223 - Combined Notice of Filings #1

Science.gov (United States)

2012-05-09

... Power Energy Services (US) LLC, Auburndale Power Partners, L.P., Cadillac Renewable Energy, LLC... County, LLC, FPL Energy New Mexico Wind, LLC, FPL Energy North Dakota Wind, LLC, FPL Energy North Dakota... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...

Mode 2 Knowledge Production in the Context of Medical Research: A Call for Further Clarifications.

Science.gov (United States)

Soofi, Hojjat

2018-03-01

The traditional researcher-driven environment of medical knowledge production is losing its dominance with the expansion of, for instance, community-based participatory or participant-led medical research. Over the past few decades, sociologists of science have debated a shift in the production of knowledge from traditional discipline-based (Mode 1) to more socially embedded and transdisciplinary frameworks (Mode 2). Recently, scholars have tried to show the relevance of Mode 2 knowledge production to medical research. However, the existing literature lacks detailed clarifications on how a model of Mode 2 knowledge production can be constructed in the context of medical research. This paper calls for such further clarifications. As a heuristic means, the advocacy for a controversial experimental stem cell therapy (Stamina) is examined. It is discussed that the example cannot be considered a step towards Mode 2 medical knowledge production. Nonetheless, the example brings to the fore some complexities of medical knowledge production that need to be further examined including: (1) the shifting landscape of defining and addressing vulnerability of research participants, (2) the emerging overlap between research and practice, and (3) public health implications of revising the standard notions of quality control and accountability.

32 CFR 776.84 - Ethics investigation.

Science.gov (United States)

2010-07-01

... 32 National Defense 5 2010-07-01 2010-07-01 false Ethics investigation. 776.84 Section 776.84... Complaint Processing Procedures § 776.84 Ethics investigation. (a) Whenever an ethics investigation is... ethics investigation: (1) To request a hearing before the investigating officer (IO); (2) To inspect all...

Immobilization of tomato (Lycopersicon esculentum) pectinmethylesterase in calcium alginate beads and its application in fruit juice clarification.

Science.gov (United States)

Bogra, Pushpa; Kumar, Ashwani; Kuhar, Kalika; Panwar, Surbhi; Singh, Randhir

2013-11-01

Clarity of fruit juices is desirable to maintain an aesthetically pleasing quality and international standards. The most commonly used enzymes in juice industries are pectinases. A partially-purified pectinmethylesterase from tomato was entrapped in calcium alginate beads and used for juice clarification. The activity yield was maximum at 1 % (w/v) CaCl2 and 2.5 % (w/v) alginate. The immobilized enzyme retained ~55 % of its initial activity (5.7 × 10(-2) units) after more than ten successive batch reactions. The Km, pH and temperature optima were increased after immobilization. The most effective clarification of fruit juice (%T620 ~60 %) by the immobilized enzyme was at 4 °C with a holding time of 20 min. The viscosity dropped by 56 % and the filterability increased by 260 %. The juice remains clear after 2 months of storage at 4 °C.

77 FR 38044 - Combined Notice of Filings #1

Science.gov (United States)

2012-06-26

...-000. Applicants: NaturEner Rim Rock Wind Energy, LLC. Description: Notice of Self Certification of Exempt Wholesale Generator Status of NaturEner Rim Rock Wind Energy, LLC. Filed Date: 6/18/12. Accession... Glacier Wind Energy 1, LLC. Description: Notice of Self-Certification of Exempt Wholesale Generator Status...

77 FR 14512 - Combined Notice of Filings #1

Science.gov (United States)

2012-03-12

... Company. Description: Schedule 4 & 10--Energy & Generator Imbalance Changes to be effective 3/5/2012... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...: 5 p.m. ET 3/23/12. Docket Numbers: ER12-458-004. Applicants: Quantum Choctaw Power, LLC. Description...

26 CFR 1.7476-2 - Notice to interested parties.

Science.gov (United States)

2010-04-01

... 1.7476-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES The Tax Court § 1.7476-2 Notice to interested parties. (a) In general... Internal Revenue Service before the date on which section 410 applies to the plan. (b) Nature of notice...

45 CFR 84.39 - Private education.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Private education. 84.39 Section 84.39 Public... Secondary Education § 84.39 Private education. (a) A recipient that provides private elementary or secondary education may not, on the basis of handicap, exclude a qualified handicapped person if the person can, with...

33 CFR 84.23 - Maneuvering light.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Maneuvering light. 84.23 Section... RULES ANNEX I: POSITIONING AND TECHNICAL DETAILS OF LIGHTS AND SHAPES § 84.23 Maneuvering light. Notwithstanding the provisions of § 84.03(f), the maneuvering light described in Rule 34(b) shall be placed...

78 FR 31914 - Combined Notice of Filings #1

Science.gov (United States)

2013-05-28

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...: ISO New England Inc. Rhode Island Engine Genco LLC Resource Termination Filing. Filed Date: 5/17/13... information, call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Dated: May 17, 2013. Nathaniel J...

78 FR 40470 - Combined Notice of Filings #1

Science.gov (United States)

2013-07-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following exempt wholesale generator filings: Docket Numbers: EG13-44...-005; ER10-1416-005; ER13- 1487-000; ER13-1488-000; ER13-1489-000. Applicants: Quantum Auburndale Power...

77 FR 6105 - Combined Notice of Filings #1

Science.gov (United States)

2012-02-07

..., FPL Energy New Mexico Wind, LLC, FPL Energy North Dakota Wind, LLC, FPL Energy North Dakota Wind II... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice.... Applicants: Alta Wind VIII, LLC, BAIF U.S. Renewable Power Holdings LLC. Description: Alta Wind VIII, LLC, et...

75 FR 11632 - Proposed Collection; Comment Request for Notice 2001-1

Science.gov (United States)

2010-03-11

... comments concerning Notice 2001-1, Employer-designed Tip Reporting Program for the Food and Beverage... Reporting Program for the Food and Beverage Industry (EmTRAC). OMB Number: 1545-1716. Notice Number: Notice...

75 FR 65472 - Combined Notice of Filings No. 1

Science.gov (United States)

2010-10-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings No. 1 September 07, 2010. Take notice that the Commission has received the following Natural Gas Pipeline Rate and..., September 15, 2010. Docket Numbers: RP10-1280-000. Applicants: Venice Gathering System, LLC. Description...

50 CFR 17.84 - Special rules-vertebrates.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 2 2010-10-01 2010-10-01 false Special rules-vertebrates. 17.84 Section 17.84 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR....84 Special rules—vertebrates. (a) Delmarva Peninsula fox squirrel (Sciurus niger cinereus). (1) The...

75 FR 61741 - Combined Notice of Filings No. 1

Science.gov (United States)

2010-10-06

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings No. 1 September 20, 2010. Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings: Docket Numbers: RP10-1305-000. Applicants: Venice Gathering System, L.L.C...

75 FR 72820 - Combined Notice Of Filings No. 1

Science.gov (United States)

2010-11-26

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice Of Filings No. 1 November 17, 2010. Take notice that the Commission has received the following Natural Gas Pipeline Rate and.... Eastern Time on Monday, November 29, 2010. Docket Numbers: RP11-1532-000. Applicants: Venice Gathering...

75 FR 65467 - Combined Notice of Filings No. 1

Science.gov (United States)

2010-10-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings No. 1 October 19, 2010. Take notice that the Commission has received the following Natural Gas Pipeline Rate and...: Venice Gathering System, L.L.C. Description: Venice Gathering System, L.L.C. submits tariff filing per...

The complex patient: A concept clarification.

Science.gov (United States)

Manning, Eli; Gagnon, Marilou

2017-03-01

Over the last decade, the concept of the "complex patient" has not only been more widely used in multidisciplinary healthcare teams and across various healthcare disciplines, but it has also become more vacuous in meaning. The uptake of the concept of the "complex patient" spans across disciplines, such as medicine, nursing, and social work, with no consistent definition. We review the chronological evolution of this concept and its surrogate terms, namely "comorbidity," "multimorbidity," "polypathology," "dual diagnosis," and "multiple chronic conditions." Drawing on key principles of concept clarification, we highlight disciplinary usage in the literature published between 2005 and 2015 in health sciences, attending to overlaps and revealing nuances of the complex patient concept. Finally, we discuss the implications of this concept for practice, research, and theory. © 2017 John Wiley & Sons Australia, Ltd.

34 CFR 84.635 - Drug-free workplace.

Science.gov (United States)

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Drug-free workplace. 84.635 Section 84.635 Education Office of the Secretary, Department of Education GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 84.635 Drug-free workplace. Drug-free workplace means a site for the...

Impact of Ovine Whey Protein Concentrates and Clarification By-Products on the Yield and Quality of Whey Cheese

OpenAIRE

Carlos D. Pereira; Olga Díaz; Angel Cobos

2007-01-01

The effects of the addition of whey protein concentrates and clarification by-products obtained from ovine cheese whey and deproteinized whey (Sorelho) on the yield and quality of the whey cheese (Requeijão) have been evaluated. Whey protein concentrates were obtained by ultrafiltration of skimmed whey and Sorelho. The clarification by-products were obtained after the treatment of the skimmed whey and Sorelho by thermocalcic precipitation and microfiltration with two membranes (0.20 and 0.65 ...

75 FR 71548 - Clarification of the Post Office Box Lock Replacement Fee

Science.gov (United States)

2010-11-24

... POSTAL SERVICE 39 CFR Part 111 Clarification of the Post Office Box Lock Replacement Fee AGENCY... of the lock replacement fee for Post Office TM boxes to reflect current practice. DATES: January 2... Standards for Domestic Mailing Services (75 FR 39477-39492). The applicability of the lock replacement fee...

Effect of membrane property and operating conditions on phytochemical properties and permeate flux during clarification of pineapple juice

KAUST Repository

Laorko, Aporn

2010-10-01

The effects of membrane property on the permeate flux, membrane fouling and quality of clarified pineapple juice were studied. Both microfiltration (membrane pore size of 0.1 and 0.2 μm) and ultrafiltration (membrane molecular weight cut-off (MWCO) of 30 and 100 kDa) membranes were employed. Membrane filtration did not have significant effects on the pH, reducing sugar and acidity of clarified juice whereas the suspended solids and microorganism were completely removed. The 0.2 μm membrane gave the highest permeate flux, total vitamin C content, total phenolic content and antioxidant capacity as well as the highest value of irreversible fouling. Based on these results, the membrane with pore size of 0.2 μm was considered to be the most suitable membrane for the clarification of pineapple juice. The optimum operating conditions for the clarification pineapple juice by membrane filtration was a cross-flow velocity of 3.4 ms-1 and transmembrane pressure (TMP) of 0.7 bar. An average flux of about 37 lm-2 h-1 was obtained during the microfiltration of pineapple juice under the optimum conditions using batch concentration mode. © 2010 Elsevier Ltd. All rights reserved.

Effect of membrane property and operating conditions on phytochemical properties and permeate flux during clarification of pineapple juice

KAUST Repository

Laorko, Aporn; Li, Zhenyu; Tongchitpakdee, Sasitorn; Chantachum, Suphitchaya; Youravong, Wirote

2010-01-01

The effects of membrane property on the permeate flux, membrane fouling and quality of clarified pineapple juice were studied. Both microfiltration (membrane pore size of 0.1 and 0.2 μm) and ultrafiltration (membrane molecular weight cut-off (MWCO) of 30 and 100 kDa) membranes were employed. Membrane filtration did not have significant effects on the pH, reducing sugar and acidity of clarified juice whereas the suspended solids and microorganism were completely removed. The 0.2 μm membrane gave the highest permeate flux, total vitamin C content, total phenolic content and antioxidant capacity as well as the highest value of irreversible fouling. Based on these results, the membrane with pore size of 0.2 μm was considered to be the most suitable membrane for the clarification of pineapple juice. The optimum operating conditions for the clarification pineapple juice by membrane filtration was a cross-flow velocity of 3.4 ms-1 and transmembrane pressure (TMP) of 0.7 bar. An average flux of about 37 lm-2 h-1 was obtained during the microfiltration of pineapple juice under the optimum conditions using batch concentration mode. © 2010 Elsevier Ltd. All rights reserved.

75 FR 74706 - Notice of Baseline Filings

Science.gov (United States)

2010-12-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Baseline Filings November 24, 2010. Centana Intrastate Pipeline, LLC. Docket No. PR10-84-001. Centana Intrastate Pipeline, LLC... applicants listed above submitted a revised baseline filing of their Statement of Operating Conditions for...

Effects of Inner Nuclear Membrane Proteins SUN1/UNC-84A and SUN2/UNC-84B on the Early Steps of HIV-1 Infection.

Science.gov (United States)

Schaller, Torsten; Bulli, Lorenzo; Pollpeter, Darja; Betancor, Gilberto; Kutzner, Juliane; Apolonia, Luis; Herold, Nikolas; Burk, Robin; Malim, Michael H

2017-10-01

Human immunodeficiency virus type 1 (HIV-1) infection of dividing and nondividing cells involves regulatory interactions with the nuclear pore complex (NPC), followed by translocation to the nucleus and preferential integration into genomic areas in proximity to the inner nuclear membrane (INM). To identify host proteins that may contribute to these processes, we performed an overexpression screen of known membrane-associated NE proteins. We found that the integral transmembrane proteins SUN1/UNC84A and SUN2/UNC84B are potent or modest inhibitors of HIV-1 infection, respectively, and that suppression corresponds to defects in the accumulation of viral cDNA in the nucleus. While laboratory strains (HIV-1 NL4.3 and HIV-1 IIIB ) are sensitive to SUN1-mediated inhibition, the transmitted founder viruses RHPA and ZM247 are largely resistant. Using chimeric viruses, we identified the HIV-1 capsid (CA) protein as a major determinant of sensitivity to SUN1, and in vitro -assembled capsid-nucleocapsid (CANC) nanotubes captured SUN1 and SUN2 from cell lysates. Finally, we generated SUN1 -/- and SUN2 -/- cells by using CRISPR/Cas9 and found that the loss of SUN1 had no effect on HIV-1 infectivity, whereas the loss of SUN2 had a modest suppressive effect. Taken together, these observations suggest that SUN1 and SUN2 may function redundantly to modulate postentry, nuclear-associated steps of HIV-1 infection. IMPORTANCE HIV-1 causes more than 1 million deaths per year. The life cycle of HIV-1 has been studied extensively, yet important steps that occur between viral capsid release into the cytoplasm and the expression of viral genes remain elusive. We propose here that the INM components SUN1 and SUN2, two members of the linker of nucleoskeleton and cytoskeleton (LINC) complex, may interact with incoming HIV-1 replication complexes and affect key steps of infection. While overexpression of these proteins reduces HIV-1 infection, disruption of the individual SUN2 and SUN1 genes

Peer-assisted learning: time for nomenclature clarification

Directory of Open Access Journals (Sweden)

Alexander Olaussen

2016-07-01

Full Text Available Background: Peer-assisted learning (PAL is used throughout all levels of healthcare education. Lack of formalised agreement on different PAL programmes may confuse the literature. Given the increasing interest in PAL as an education philosophy, the terms need clarification. The aim of this review is to 1 describe different PAL programmes, 2 clarify the terminology surrounding PAL, and 3 propose a simple pragmatic way of defining PAL programmes based on their design. Methods: A review of current PAL programmes within the healthcare setting was conducted. Each programme was scrutinised based on two aspects: the relationship between student and teacher, and the student to teacher ratio. The studies were then shown to fit exclusively into the novel proposed classification. Results: The 34 programmes found, demonstrate a wide variety in terms used. We established six terms, which exclusively applied to the programmes. The relationship between student and teacher was categorised as peer-to-peer or near-peer. The student to teacher ratio suited three groupings, named intuitively ‘Mentoring’ (1:1 or 1:2, ‘Tutoring’ (1:3–10, and ‘Didactic’ (1:>10. From this, six novel terms – all under the heading of PAL – are suggested: ‘Peer Mentoring’, ‘Peer Tutoring’, ‘Peer Didactic’, ‘Near-Peer Mentoring’, ‘Near-Peer Tutoring’, and ‘Near-Peer Didactic’. Conclusions: We suggest herein a simple pragmatic terminology to overcome ambiguous terminology. Academically, clear terms will allow effective and efficient research, ensuring furthering of the educational philosophy.

Peer-assisted learning: time for nomenclature clarification

Science.gov (United States)

Olaussen, Alexander; Reddy, Priya; Irvine, Susan; Williams, Brett

2016-01-01

Background Peer-assisted learning (PAL) is used throughout all levels of healthcare education. Lack of formalised agreement on different PAL programmes may confuse the literature. Given the increasing interest in PAL as an education philosophy, the terms need clarification. The aim of this review is to 1) describe different PAL programmes, 2) clarify the terminology surrounding PAL, and 3) propose a simple pragmatic way of defining PAL programmes based on their design. Methods A review of current PAL programmes within the healthcare setting was conducted. Each programme was scrutinised based on two aspects: the relationship between student and teacher, and the student to teacher ratio. The studies were then shown to fit exclusively into the novel proposed classification. Results The 34 programmes found, demonstrate a wide variety in terms used. We established six terms, which exclusively applied to the programmes. The relationship between student and teacher was categorised as peer-to-peer or near-peer. The student to teacher ratio suited three groupings, named intuitively ‘Mentoring’ (1:1 or 1:2), ‘Tutoring’ (1:3–10), and ‘Didactic’ (1:>10). From this, six novel terms – all under the heading of PAL – are suggested: ‘Peer Mentoring’, ‘Peer Tutoring’, ‘Peer Didactic’, ‘Near-Peer Mentoring’, ‘Near-Peer Tutoring’, and ‘Near-Peer Didactic’. Conclusions We suggest herein a simple pragmatic terminology to overcome ambiguous terminology. Academically, clear terms will allow effective and efficient research, ensuring furthering of the educational philosophy. PMID:27415590

77 FR 52610 - Pesticides; Microbial Pesticide Definitions and Applicability; Clarification and Availability of...

Science.gov (United States)

2012-08-30

... corrections to words and references. Finally, EPA is announcing the availability of a final microbial... nationally recognized culture collection. Collectively, the final rule clarifications and revisions, as well... sample in a nationally recognized culture collection, did not have an accompanying test guideline and...

Task clarification, performance feedback, and social praise: Procedures for improving the customer service of bank tellers.

Science.gov (United States)

Crowell, C R; Anderson, D C; Abel, D M; Sergio, J P

1988-01-01

Customer service for bank tellers was defined in terms of 11 verbal behavior categories. An audio-recording system was used to track the occurrence of behaviors in these categories for six retail banking tellers. Three behavior management interventions (task clarification, performance feedback, and social praise), applied in sequence, were designed to improve overall teller performance with regard to the behavioral categories targeted. Clarification was accomplished by providing clear delineation of the various target categories, with specific examples of the behaviors in each. Feedback entailed presentation of ongoing verbal and visual information regarding teller performance. Praise consisted of verbal recognition of teller performance by branch managers. Results showed that clarification effects emerged quickly, producing an overall increase in desired behaviors of 12% over baseline. Feedback and praise effects occurred more gradually, resulting in overall increases of 6% and 7%, respectively. A suspension of all procedures led to a decline in overall performance, whereas reinstatement of feedback and praise was again accompanied by performance improvement. These findings extend the generality of behavior management applications and help to distinguish between possible antecedent and consequent effects of performance feedback.

45 CFR 84.21 - Discrimination prohibited.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discrimination prohibited. 84.21 Section 84.21... Discrimination prohibited. No qualified handicapped person shall, because a recipient's facilities are... in, or otherwise be subjected to discrimination under any program or activity to which this part...

All Values Are Equal, But Some Are More Equal Than Others: A Critique and Redefinition of Values Clarification. Monograph Series No. 102 Code C-9.

Science.gov (United States)

McKnight, Richard

This literature review presents the essentials of the theory of Values Clarification and its fundamental terms, and makes a critical analysis of the Values Clarification Theory of Valuation. (Author/JLL)

Values clarification as a technique for family planning education.

Science.gov (United States)

Toohey, J V; Valenzuela, G J

1983-02-01

A Spanish language family planning education program utilizing the dynamics of values clarification has been designed and implemented in the state of Oaxaca, Mexico. The design of the program features three basic personality identification activities to help individuals identify other dimensions of adult life expression than child rearing. In addition, a series of simple and precise scenarios specifically related to family planning are presented. Each scenario is accompanied by a set of valuing questions that direct the learner to respond to the scenario. The activity booklet is entitled, "Clarification De Valores En La Planificacion Familar." The booklet requires the learner to make responses to the learning materials. Responses are then used as a basis for inferring that people are comprehending and above all personalizing knowledge about themselves and their culture and family planning. The program is cross cultural and can be used in Spanish speaking communities in the U.S. Its English language form can be used with English speaking target populations. Statistical analysis of seven critical categories of the program indicated that the shifts in attitudes from pre-to post-values, whether positive or negative (desirable or undesirable), were not significant at the .05 level of confidence. It should, however, be noted that small shifts in the rate of natural increase, or rate of natural decrease for population growth can have a dramatic effect on population growth when multiplied by time.

A low plasma 1,25(OH)2 vitamin D/PTH (1-84) ratio predicts worsening of renal function in patients with chronic heart failure.

Science.gov (United States)

Masson, Serge; Barlera, Simona; Colotta, Francesco; Magnoli, Michela; Bonelli, Fabrizio; Moro, Milena; Marchioli, Roberto; Tavazzi, Luigi; Tognoni, Gianni; Latini, Roberto

2016-12-01

Dysregulation of the vitamin D system promotes renal dysfunction and has direct detrimental effects on the heart. Progressive deterioration of renal function is common in patients with chronic heart failure (HF) and is invariably associated with unfavorable outcomes which can be improved by early identification and timely interventions. We examined the relation between two plasma markers of vitamin D metabolism and worsening of renal function (WRF) in a large cohort of patients with chronic HF. Plasma levels of 1,25-dihydroxyvitamin D (1,25(OH) 2 D) and parathyroid hormone PTH (1-84) were measured in 1237 patients with clinical evidence of chronic and stable HF enrolled in the multicentre GISSI-HF trial and followed for 3.9years. We examined the relation of 1,25(OH) 2 D, PTH(1-84), and their ratio with WRF, defined as first increase in serum creatinine concentration ≥0.3mg/dL and ≥25% at two consecutive measurements at any time during the study. Lower 1,25(OH) 2 D/PTH(1-84) ratio was associated with a higher baseline serum concentration of creatinine, winter season, female sex and older age; 335 patients (29.6%) experienced an episode of WRF. After adjustment, a lower 1,25(OH) 2 D/PTH(1-84) ratio remained significantly associated with a higher risk of WRF (HR=0.75 [0.62-0.90], p=0.002) and correctly reclassified events. This ratio also independently predicted mortality and admission to hospital for cardiovascular reasons. The plasma 1,25(OH) 2 D/PTH(1-84) ratio is a promising indicator of future risk of deterioration of renal function in patients with chronic HF and mild renal impairment, that may serve to optimize therapies and improve outcomes. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

24 CFR 8.4 - Discrimination prohibited.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Discrimination prohibited. 8.4... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT General Provisions § 8.4 Discrimination prohibited. (a) No... in, be denied the benefits of, or otherwise be subjected to discrimination under any program or...

Increasing Customer Service Behaviors Using Manager-Delivered Task Clarification and Social Praise

Science.gov (United States)

Rice, Anna; Austin, John; Gravina, Nicole

2009-01-01

This project assessed an intervention to improve employee customer service behaviors (correct greetings and closing behaviors). A combination of task clarification and manager-delivered social praise resulted in increased correct greeting from 11.5% to 66% and correct closing from 8% to 70%. The effect was maintained at a 48-week follow-up for…

Clarification technologies for monoclonal antibody manufacturing processes: Current state and future perspectives.

Science.gov (United States)

Singh, Nripen; Arunkumar, Abhiram; Chollangi, Srinivas; Tan, Zhijun George; Borys, Michael; Li, Zheng Jian

2016-04-01

Considerable progress has been made increasing productivity of cell cultures to meet the rapidly growing demand for antibody biopharmaceuticals through increased cell densities and longer culture times. This in turn has dramatically increased the burden of process and product related impurities on the purification processes. In addition, current trends in the biopharmaceutical industry point toward both increased productivity and targeting smaller patient populations for new indications. Taken together, these developments are driving the industry to explore alternative separation technologies as a future manufacturing strategy. Clarification technologies well established in other industries, such as flocculation and precipitation are increasingly considered as a viable solution to address this bottleneck in antibody processes. However, several technical issues need to be fully addressed including suitability as a platform application, robustness, process cost, toxicity, and clearance. This review will focus on recent efforts to incorporate new generation clarification technologies for mammalian cell cultures producing monoclonal antibodies as well as challenges to their implementation supported by a case study. © 2015 Wiley Periodicals, Inc.

47 CFR 1.403 - Notice and availability.

Science.gov (United States)

2010-10-01

... and Related Pleadings § 1.403 Notice and availability. All petitions for rule making (other than..., nature of the proposal, and date of filing, Petitions for rule making are available at the Commission's...

45 CFR 84.23 - New construction.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false New construction. 84.23 Section 84.23 Public... construction. (a) Design and construction. Each facility or part of a facility constructed by, on behalf of, or... of the facility is readily accessible to and usable by handicapped persons, if the construction was...

Pits and adatoms at the interface of 1-ML C84/Ag (111)

International Nuclear Information System (INIS)

Wang Peng; Zhang Han-Jie; Li Yan-Jun; Sheng Chun-Qi; Li Wen-Jie; Xing Xiu-Na; Li Hai-Yang; He Pi-Mo; Bao Shi-Ning; Li Hong-Nian

2013-01-01

We prepare a well-defined C 84 monolayer on the surface of Ag (111) and study the geometric structure by scanning tunneling microscopy (STM). The C 84 molecules form a nearly close-packed incommensurate R30° lattice. The lattice is long-distance ordered with numerous local disorders. The monolayer exhibits complex bright/dim contrast; the largest height difference between the molecules can be greater than 0.4 nm. Annealing the monolayer at 380 °C can desorb part of the molecules, but more than sixty percent molecules stay on the Ag (111) surface even after the sample has been annealed at 650 °C. Our analyses reveal that the 7-atom pits form beneath many molecules. Some other molecules sit at the 1-atom pits. Ag adatoms (those removed substrate atoms, accompanying the pit formation) play a very important role in this system. The adatoms can either stabilize or destabilize the monolayer, depending on the distribution manner of the adatoms at the interface. The distribution manner is determined by the co-play of the following factors: the dimension of the interstitial regions of the C 84 overlayer, the number of the adatoms, and the long-distance migration of part adatoms. (condensed matter: structural, mechanical, and thermal properties)

Energy research program 84

International Nuclear Information System (INIS)

1984-01-01

The energy research program 84 (EFP-84) is prepared by the Danish Ministry of Energy in order to continue the extension of the Danish energy research and development started through the former Trade Ministry's programs EM-1 (1976) and EM-2 (1978), and the Ministry of Energy's programs EFP-80, EFP-81, EFP-82 and EFP-83. The new program is a continuation of the activities in the period 1984-86 with a total budget of 112 mio. DKK. The program gives a brief description of background, principles, organization and financing, and a detailed description of each research area. (ln)

Hints for clarification of influencing factors in case of occupational liver diseases

Energy Technology Data Exchange (ETDEWEB)

Zober, A; Raithel, H; Valentin, H

1981-05-01

Clarification of influencing factors is of great importance in suspected occupational liver diseases. Hints are given on the basis of the author's own experience and after critical evaluation of the relevant literature. Most important are: 1) Establishment of a comprehensive working anamnesis with special regard to specific features of the job, exposure patterns, and all working materials; 2) assessment of the hepatotoxic potential of the suspected working material according to the present state of knowledge in working medicine and toxicology; 3) objectification and quantification of the suspected noxious substances at the place of work by means of air analysis and analysis of the biological matter; 4) differential diagnosis in view of possible competitive influencing factors.

24 CFR 84.24 - Program income.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Program income. 84.24 Section 84.24... income. (a) HUD shall apply the standards set forth in this section in requiring recipient organizations to account for program income related to projects financed in whole or in part with Federal funds. (b...

78 FR 17389 - Texas Eastern Transmission, LP; Notice of Application for Certificate of Public Convenience and...

Science.gov (United States)

2013-03-21

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. CP13-84-000; PF12-19-000] Texas Eastern Transmission, LP; Notice of Application for Certificate of Public Convenience and Necessity and Authorization for Abandonment Take notice that on February 27, 2013, Texas Eastern...

24 CFR 84.50 - Purpose of reports and records.

Science.gov (United States)

2010-04-01

... Records § 84.50 Purpose of reports and records. Sections 84.51 through 84.53 set forth the procedures for monitoring and reporting on the recipient's financial and program performance and the necessary standard... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Purpose of reports and records. 84...

Role Clarification Processes for Better Integration of Nurse Practitioners into Primary Healthcare Teams: A Multiple-Case Study

Directory of Open Access Journals (Sweden)

Isabelle Brault

2014-01-01

Full Text Available Role clarity is a crucial issue for effective interprofessional collaboration. Poorly defined roles can become a source of conflict in clinical teams and reduce the effectiveness of care and services delivered to the population. Our objective in this paper is to outline processes for clarifying professional roles when a new role is introduced into clinical teams, that of the primary healthcare nurse practitioner (PHCNP. To support our empirical analysis we used the Canadian National Interprofessional Competency Framework, which defines the essential components for role clarification among professionals. A qualitative multiple-case study was conducted on six cases in which the PHCNP role was introduced into primary care teams. Data collection included 34 semistructured interviews with key informants involved in the implementation of the PHCNP role. Our results revealed that the best performing primary care teams were those that used a variety of organizational and individual strategies to carry out role clarification processes. From this study, we conclude that role clarification is both an organizational process to be developed and a competency that each member of the primary care team must mobilize to ensure effective interprofessional collaboration.

Role clarification processes for better integration of nurse practitioners into primary healthcare teams: a multiple-case study.

Science.gov (United States)

Brault, Isabelle; Kilpatrick, Kelley; D'Amour, Danielle; Contandriopoulos, Damien; Chouinard, Véronique; Dubois, Carl-Ardy; Perroux, Mélanie; Beaulieu, Marie-Dominique

2014-01-01

Role clarity is a crucial issue for effective interprofessional collaboration. Poorly defined roles can become a source of conflict in clinical teams and reduce the effectiveness of care and services delivered to the population. Our objective in this paper is to outline processes for clarifying professional roles when a new role is introduced into clinical teams, that of the primary healthcare nurse practitioner (PHCNP). To support our empirical analysis we used the Canadian National Interprofessional Competency Framework, which defines the essential components for role clarification among professionals. A qualitative multiple-case study was conducted on six cases in which the PHCNP role was introduced into primary care teams. Data collection included 34 semistructured interviews with key informants involved in the implementation of the PHCNP role. Our results revealed that the best performing primary care teams were those that used a variety of organizational and individual strategies to carry out role clarification processes. From this study, we conclude that role clarification is both an organizational process to be developed and a competency that each member of the primary care team must mobilize to ensure effective interprofessional collaboration.

42 CFR 84.103 - Man tests; performance requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Man tests; performance requirements. 84.103 Section 84.103 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing Apparatus § 84.103 Man tests;...

Study of alternative strategies to the task clarification activity of the market-pull product development process model

OpenAIRE

Motte, Damien

2009-01-01

A very large majority of the current product development process models put forward in textbooks present a homogenous structure, what Ulrich & Eppinger [1] call the market-pull model, presented as a generic one, while other possible product development process models are merely seen as variants. This paper focuses on the task clarification and derived activities (mainly the systematic search for customer needs through market study and the supplementary development costs it entails) and in...

Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFα enhances GPR84 expression in adipocytes.

Science.gov (United States)

Nagasaki, Hiroshi; Kondo, Takaaki; Fuchigami, Masahiro; Hashimoto, Hiroyuki; Sugimura, Yoshihisa; Ozaki, Nobuaki; Arima, Hiroshi; Ota, Akira; Oiso, Yutaka; Hamada, Yoji

2012-02-17

In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity. Copyright © 2012 Federation of European Biochemical Societies. All rights reserved.

45 CFR 84.38 - Preschool and adult education.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Preschool and adult education. 84.38 Section 84.38..., and Secondary Education § 84.38 Preschool and adult education. A recipient to which this subpart applies that provides preschool education or day care or adult education may not, on the basis of handicap...

45 CFR 84.53 - Drug and alcohol addicts.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Drug and alcohol addicts. 84.53 Section 84.53... Social Services § 84.53 Drug and alcohol addicts. A recipient to which this subpart applies that operates... drug or alcohol abuser or alcoholic who is suffering from a medical condition, because of the person's...

42 CFR 84.101 - Man test 5; requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Man test 5; requirements. 84.101 Section 84.101 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing Apparatus § 84.101 Man test 5; requirements....

42 CFR 84.102 - Man test 6; requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Man test 6; requirements. 84.102 Section 84.102 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing Apparatus § 84.102 Man test 6; requirements....

42 CFR 84.52 - Respiratory hazards; classification.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Respiratory hazards; classification. 84.52 Section... SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Classification of Approved Respirators; Scope of Approval; Atmospheric Hazards; Service Time § 84.52 Respiratory...

26 CFR 301.6303-1 - Notice and demand for tax.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Notice and demand for tax. 301.6303-1 Section... demand for tax. (a) General rule. Where it is not otherwise provided by the Code, the district director... demanding payment thereof. Such notice shall be given as soon as possible and within 60 days. However, the...

Clarification of olive mill and winery wastewater by means of clay-polymer nanocomposites

Energy Technology Data Exchange (ETDEWEB)

Rytwo, Giora, E-mail: rytwo@telhai.ac.il [Tel Hai College, Dept. of Environmental Sciences, Upper Galilee 12210 (Israel); Environmental Physical Chemistry Laboratory, MIGAL, Galilee Technological Center, Kiryat Shmona (Israel); Lavi, Roy; Rytwo, Yuval; Monchase, Hila [Environmental Physical Chemistry Laboratory, MIGAL, Galilee Technological Center, Kiryat Shmona (Israel); Dultz, Stefan [Institute of Soil Science, Leibniz University Hannover, Herrenhaeuser Str. 2, D-30419 Hannover (Germany); Koenig, Tom N. [Environmental Physical Chemistry Laboratory, MIGAL, Galilee Technological Center, Kiryat Shmona (Israel)

2013-01-01

Highly polluted effluents from olive mills and wineries, among others, are unsuitable for discharge into standard sewage-treatment plants due to the large amounts of organic and suspended matter. Efficiency of all management practices for such effluents depends on an effective pretreatment that lowers the amount of suspended solids. Such pretreatments are usually based on three separate stages, taking a total of 2 to 6 h: coagulation-neutralizing the colloids, flocculation-aggregating the colloids into larger particles, and separation via filtration or decanting. Previous studies have presented the concept of coagoflocculation based on the use of clay-polymer nanocomposites. This process adds a higher density clay particle to the flocs, accelerating the process to between 15 and 60 min. This study examined suitable nanocomposites based on different clays and polymers. The charge of the compounds increased proportionally to the polymer-to-clay ratio. X-ray diffraction (XRD) measurements indicated that in sepiolite-based nanocomposites there is no change in the structure of the mineral, whereas in smectite-based nanocomposites, the polymer intercalates between the clay layers and increases the spacing depending on the polymer-to-clay ratio. Efficiency of the coagoflocculation process was studied with a dispersion analyzer. Sequential addition of olive mill or winery effluents with a boosting dose of nanocomposites may yield a very efficient and rapid clarification pretreatment. Highlights: Black-Right-Pointing-Pointer Nanocomposites yielded clarification of olive mill (OMW) and winery effluents (WW). Black-Right-Pointing-Pointer In smectite based nanocomposites intercalation of the polymer was measured. Black-Right-Pointing-Pointer In sepiolite based nanocomposites no changes in the spacing were observed. Black-Right-Pointing-Pointer Colloidal neutralization is the main clarification process in WW but not in OMW. Black-Right-Pointing-Pointer Several cycles of

Clarification of olive mill and winery wastewater by means of clay–polymer nanocomposites

International Nuclear Information System (INIS)

Rytwo, Giora; Lavi, Roy; Rytwo, Yuval; Monchase, Hila; Dultz, Stefan; König, Tom N.

2013-01-01

Highly polluted effluents from olive mills and wineries, among others, are unsuitable for discharge into standard sewage-treatment plants due to the large amounts of organic and suspended matter. Efficiency of all management practices for such effluents depends on an effective pretreatment that lowers the amount of suspended solids. Such pretreatments are usually based on three separate stages, taking a total of 2 to 6 h: coagulation—neutralizing the colloids, flocculation—aggregating the colloids into larger particles, and separation via filtration or decanting. Previous studies have presented the concept of coagoflocculation based on the use of clay–polymer nanocomposites. This process adds a higher density clay particle to the flocs, accelerating the process to between 15 and 60 min. This study examined suitable nanocomposites based on different clays and polymers. The charge of the compounds increased proportionally to the polymer-to-clay ratio. X-ray diffraction (XRD) measurements indicated that in sepiolite-based nanocomposites there is no change in the structure of the mineral, whereas in smectite-based nanocomposites, the polymer intercalates between the clay layers and increases the spacing depending on the polymer-to-clay ratio. Efficiency of the coagoflocculation process was studied with a dispersion analyzer. Sequential addition of olive mill or winery effluents with a boosting dose of nanocomposites may yield a very efficient and rapid clarification pretreatment. Highlights: ► Nanocomposites yielded clarification of olive mill (OMW) and winery effluents (WW). ► In smectite based nanocomposites intercalation of the polymer was measured. ► In sepiolite based nanocomposites no changes in the spacing were observed. ► Colloidal neutralization is the main clarification process in WW but not in OMW. ► Several cycles of effluents might be added to an initial dose of nanocomposites.

15 CFR 2003.1 - Notice of public hearings.

Science.gov (United States)

2010-01-01

... UNITED STATES TRADE REPRESENTATIVE REGULATIONS OF TRADE POLICY STAFF COMMITTEE § 2003.1 Notice of public... generalized tariff preferences for the listed articles; (b) Whenever the Special Representative or the Deputy...

78 FR 58500 - Water Quality Standards Regulatory Clarifications Proposed Rule; Public Meeting and Public Webinars

Science.gov (United States)

2013-09-24

... the proposed rule ``Water Quality Standards Regulatory Clarifications,'' which was published... the federal water quality standards (WQS) regulation at 40 CFR Part 131 which helps implement the..., the proposed rule will lead to improved water quality standard development, implementation and...

48 CFR 52.230-1 - Cost Accounting Standards Notices and Certification.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Cost Accounting Standards... Provisions and Clauses 52.230-1 Cost Accounting Standards Notices and Certification. As prescribed in 30.201-3, insert the following provisions: Cost Accounting Standards Notices and Certification (OCT 2008...

12 CFR 34.84 - Future bank expansion.

Science.gov (United States)

2010-01-01

..., the bank shall state, by resolution of the board of directors or an appropriately authorized bank... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Future bank expansion. 34.84 Section 34.84 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY REAL ESTATE LENDING AND...

43 CFR 12.84 - Termination for convenience.

Science.gov (United States)

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Termination for convenience. 12.84 Section 12.84 Public Lands: Interior Office of the Secretary of the Interior ADMINISTRATIVE AND AUDIT... Termination for convenience. Except as provided in § 12.83 awards may be terminated in whole or in part only...

On the suitability of fast and frugal heuristics for designing values clarification methods in patient decision aids: a critical analysis.

Science.gov (United States)

Pieterse, Arwen H; de Vries, Marieke

2013-09-01

Increasingly, patient decision aids and values clarification methods (VCMs) are being developed to support patients in making preference-sensitive health-care decisions. Many VCMs encourage extensive deliberation about options, without solid theoretical or empirical evidence showing that deliberation is advantageous. Research suggests that simple, fast and frugal heuristic decision strategies sometimes result in better judgments and decisions. Durand et al. have developed two fast and frugal heuristic-based VCMs. To critically analyse the suitability of the 'take the best' (TTB) and 'tallying' fast and frugal heuristics in the context of patient decision making. Analysis of the structural similarities between the environments in which the TTB and tallying heuristics have been proven successful and the context of patient decision making and of the potential of these heuristic decision processes to support patient decision making. The specific nature of patient preference-sensitive decision making does not seem to resemble environments in which the TTB and tallying heuristics have proven successful. Encouraging patients to consider less rather than more relevant information potentially even deteriorates their values clarification process. Values clarification methods promoting the use of more intuitive decision strategies may sometimes be more effective. Nevertheless, we strongly recommend further theoretical thinking about the expected value of such heuristics and of other more intuitive decision strategies in this context, as well as empirical assessments of the mechanisms by which inducing such decision strategies may impact the quality and outcome of values clarification. © 2011 John Wiley & Sons Ltd.

34 CFR 84.100 - What does this part do?

Science.gov (United States)

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false What does this part do? 84.100 Section 84.100 Education Office of the Secretary, Department of Education GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 84.100 What does this part do? This part carries out the...

75 FR 34988 - Notice of Intent To Grant Exclusive Patent License; Fiber Optic Sensor Systems Technology...

Science.gov (United States)

2010-06-21

...; Fiber Optic Sensor Systems Technology Corporation AGENCY: Department of the Navy, DoD. ACTION: Notice. SUMMARY: The Department of the Navy hereby gives notice of its intent to grant to Fiber Optic Sensor... inventions described in U.S. Patent No. 7,149,374: Fiber Optic Pressure Sensor, Navy Case No. 84,557.//U.S...

26 CFR 1.414(r)-4 - Qualified separate line of business-fifty-employee and notice requirements.

Science.gov (United States)

2010-04-01

...-employee and notice requirements. 1.414(r)-4 Section 1.414(r)-4 Internal Revenue INTERNAL REVENUE SERVICE... Bonus Plans, Etc. § 1.414(r)-4 Qualified separate line of business—fifty-employee and notice... business (as determined under § 1.414(r)-3) satisfies the 50-employee and notice requirements of § 1.414(r...

34 CFR 84.105 - Does this part apply to me?

Science.gov (United States)

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Does this part apply to me? 84.105 Section 84.105 Education Office of the Secretary, Department of Education GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE... Education; or (2) A(n) ED awarding official. (See definitions of award and recipient in §§ 84.605 and 84.660...

78 FR 58202 - Federal Tort Claims Act (FTCA) Medical Malpractice Program Regulations: Clarification of FTCA...

Science.gov (United States)

2013-09-23

...) Medical Malpractice Program Regulations: Clarification of FTCA Coverage for Services Provided to Non... not limit coverage to childhood vaccinations; and (3) To add the following new example as subsection 6... that have substantial direct effects on the states, the relationship between the national government...

Swimming Pool Hygiene: Self-Monitoring, Task Clarification, and Performance Feedback Increase Lifeguard Cleaning Behaviors

Science.gov (United States)

Rose, Henry M. S.; Ludwig, Timothy D.

2009-01-01

The effects of task clarification, self-monitoring, and performance feedback on cleaning behaviors of 9 lifeguards in 3 performance areas (vacuuming, lobby tidying, and pool deck maintenance) were investigated using an ABA reversal design at a county swim complex. A specific task in each performance area was used as a behavioral control. Following…

7 CFR 319.56-1 - Notice of quarantine.

Science.gov (United States)

2010-01-01

... quarantine. (a) Under section 412(a) of the Plant Protection Act, the Secretary of Agriculture may prohibit... 7 Agriculture 5 2010-01-01 2010-01-01 false Notice of quarantine. 319.56-1 Section 319.56-1 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION...

Chitosan-immobilized pectinolytics with novel catalytic features and fruit juice clarification potentialities.

Science.gov (United States)

Irshad, Muhammad; Murtza, Aimen; Zafar, Muddassar; Bhatti, Khizar Hayat; Rehman, Abdul; Anwar, Zahid

2017-11-01

Biological macromolecules are primarily composed of complex polysaccharides that strengthen microbial growth for the production of industrially relevant enzymes. The presence of polysaccharides in the form of the disrupted cell wall and cell materials are among major challenges in the fruit juice industry. The breakdown of such biological macromolecules including cellulose and pectin is vital for the juices processing. In this background, pectinolytic enzymes including polygalacturonase (PG), pectin lyase (PL), and pectin methylesterase (PME) were isolated from Aspergillus ornatus, statistically optimized and purified via ammonium sulfate fractionation (ASF), dialysis, and Sephadex G-100 gel permeation chromatography. After passing through Sephadex G-100 column, PG, PL, and PME were 2.60-fold, 3.30-fold, and 4.52-fold purified with specific activities of 475.2U/mg, 557.1U/mg, and 205.7U/mg. The active PG, PL, and PME, each separately, were surface immobilized using various concentrations of chitosan and dextran polyaldehyde as a macromolecular crosslinking agent. Prior to exploit for juice clarification purposes, various parameters including pH, thermal and Michaelis-Menten kinetic constants of purified and chitosan-immobilized fractions were investigated. A considerable improvement in the pH and thermal profiles was recorded after immobilization. However, the negligible difference between the K m and V max values of purified free and chitosan-immobilized fractions revealed that the conformational flexibility of pectinolytics was retained as such. A significant color and turbidity reductions were recorded after 60min treatment with CTS-PG, followed by CTS-PME, and CTS-PL. It can be concluded that the clarification of apples, mango, peach, and apricot juices was greatly affected by CTS-PG, CTS-PME, and CTS-PL treatments rendering them as potential candidatures for food industry applications. Copyright © 2017 Elsevier B.V. All rights reserved.

Comparison of GRCop-84 to Other High Thermal Conductive Cu Alloys

Science.gov (United States)

deGroh, Henry C., III; Ellis, David L.; Loewenthal, William S.

2007-01-01

The mechanical properties of five copper alloys (GRCop-84, AMZIRC, GlidCop Al-15, Cu-1Cr-0.1Zr, Cu-0.9Cr) competing in high temperature, high heat flux applications such as rocket nozzles, were compared. Tensile, creep, thermal expansion, and compression tests are presented. Tests were done on as-received material, and on material which received a simulated brazing heat treatment at 935 C. The 935 C heat treatment weakened AMZIRC, Cu-1Cr-0.1Zr, and Cu-0.9Cr, and the strength of as-received AMZIRC dropped precipitously as test temperatures exceeded 500 C. The properties of GlidCop Al-15 and GRCop-84 were not significantly affected by the 935 C heat treatment. Thus GRCop-84 is better than AMZIRC, Cu-1Cr-0.1Zr, and Cu-0.9Cr at temperatures greater than 500 C. Ductility was lowest in GlidCop Al-15 and Cu-0.9Cr. The creep properties of GRCop-84 were superior to those of brazed AMZIRC, Cu-1Cr-0.1Zr, and Cu-0.9Cr. At equivalent rupture life and stress, GRCop-84 had a 150 C temperature advantage over brazed AMZIRC; for equivalent rupture life and temperature GRCop-84 was two times stronger. The advantages of GRCop-84 over GlidCop Al-15 associated with ease of processing were confirmed by GlidCop s marginal ductility. In the post brazed condition, GRCop-84 was found to be superior to the other alloys due to its greater strength and creep resistance (compared to AMZIRC, Cu-1Cr-0.1Zr, and Cu-0.9Cr) and ductility (compared to GlidCop Al-15)

Performance of Hollow Fiber Ultrafiltration Membranes in the Clarification of Blood Orange Juice

Directory of Open Access Journals (Sweden)

Carmela Conidi

2015-12-01

Full Text Available The clarification of blood orange juice by ultrafiltration (UF was investigated by using three hollow fiber membrane modules characterized by different membrane materials (polysulfone (PS and polyacrylonitrile (PAN and molecular weight cut-off (MWCO (50 and 100 kDa. The performance of selected membranes was investigated in terms of productivity and selectivity towards total anthocyanin content (TAC, total phenolic content (TPC, and total antioxidant activity (TAA. All selected membranes allowed a good preservation of antioxidant compounds; however, the most suitable membrane for the clarification of the juice was found to be the PS 100 kDa membrane. In optimized operating conditions this membrane exhibited steady-state fluxes of 7.12 L/m2h, higher than those measured for other investigated membranes. Rejections towards TPC and TAA were of the order of 17.5% and 15%, respectively. These values were lower than those determined for PS 50 kDa and PAN 50 kDa membranes. In addition, the PS 100 kDa membrane exhibited a lower rejection (7.3% towards TAC when compared to the PS 50 kDa membrane (9.2%.

33 CFR 84.24 - High-speed craft.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false High-speed craft. 84.24 Section... RULES ANNEX I: POSITIONING AND TECHNICAL DETAILS OF LIGHTS AND SHAPES § 84.24 High-speed craft. (a) The masthead light of high-speed craft with a length to breadth ratio of less than 3.0 may be placed at a...

42 CFR 84.197 - Respirator containers; minimum requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Respirator containers; minimum requirements. 84.197... Cartridge Respirators § 84.197 Respirator containers; minimum requirements. Respirators shall be equipped with a substantial, durable container bearing markings which show the applicant's name, the type and...

42 CFR 84.174 - Respirator containers; minimum requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Respirator containers; minimum requirements. 84.174... Air-Purifying Particulate Respirators § 84.174 Respirator containers; minimum requirements. (a) Except..., durable container bearing markings which show the applicant's name, the type of respirator it contains...

Impact of Ovine Whey Protein Concentrates and Clarification By-Products on the Yield and Quality of Whey Cheese

Directory of Open Access Journals (Sweden)

Carlos D. Pereira

2007-01-01

Full Text Available The effects of the addition of whey protein concentrates and clarification by-products obtained from ovine cheese whey and deproteinized whey (Sorelho on the yield and quality of the whey cheese (Requeijão have been evaluated. Whey protein concentrates were obtained by ultrafiltration of skimmed whey and Sorelho. The clarification by-products were obtained after the treatment of the skimmed whey and Sorelho by thermocalcic precipitation and microfiltration with two membranes (0.20 and 0.65 μm pore size. Next, the liophilization of the corresponding retentates was carried out. Each powder was added in three different mass ratios: 0.5, 1.0 and 1.5 %. The addition of the powders caused higher yields of the whey cheese – mainly the one with the additional whey powder – but it did not affect the strength of the products. The retention of water and other components of whey and milk in the whey cheese was influenced by the protein composition of the powders. In relation to colour parameters, the whey cheese manufactured with ultrafiltration and microfiltration retentate powders showed lower values of ligthness than the control whey cheese – mainly the whey cheese with 1.5 % of added powders. The microstructure constituted of small aggregates in the whey cheese manufactured with ultrafiltration and 0.20-μm microfiltration retentate powders and also by large, smooth structures in the other whey cheeses, especially in batches with added Sorelho powders.

26 CFR 1.853-3 - Notice to shareholders.

Science.gov (United States)

2010-04-01

... respect to the holders of interest in the unit investment trust, it shall so notify the Internal Revenue... Internal Revenue Service that the regulated investment company has failed to comply with the agreement... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Notice to shareholders. 1.853-3 Section 1.853-3...

42 CFR 84.134 - Respirator containers; minimum requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Respirator containers; minimum requirements. 84.134... Respirators § 84.134 Respirator containers; minimum requirements. Supplied-air respirators shall be equipped with a substantial, durable container bearing markings which show the applicant's name, the type and...

42 CFR 84.1134 - Respirator containers; minimum requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Respirator containers; minimum requirements. 84... Combination Gas Masks § 84.1134 Respirator containers; minimum requirements. (a) Except as provided in paragraph (b) of this section each respirator shall be equipped with a substantial, durable container...

42 CFR 84.74 - Apparatus containers; minimum requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Apparatus containers; minimum requirements. 84.74...-Contained Breathing Apparatus § 84.74 Apparatus containers; minimum requirements. (a) Apparatus may be equipped with a substantial, durable container bearing markings which show the applicant's name, the type...

75 FR 6672 - HIV/AIDS Bureau; Policy Notice 99-02 Amendment #1

Science.gov (United States)

2010-02-10

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Resources and Services Administration HIV/AIDS...). ACTION: Notice of rescinded Policy Notice 99-02, Amendment 1. SUMMARY: The HRSA HIV/AIDS Bureau (HAB... Service (PHS) Act, Ryan White HIV/AIDS Program funds for housing referral services and short-term or...

76 FR 61660 - Cost Accounting Standards: Clarification of the Exemption From Cost Accounting Standards for Firm...

Science.gov (United States)

2011-10-05

... Accounting Standards: Clarification of the Exemption From Cost Accounting Standards for Firm-Fixed-Price... Management and Budget (OMB), Office of Federal Procurement Policy, Cost Accounting Standards Board. ACTION: Proposed rule. SUMMARY: The Office of Federal Procurement Policy (OFPP), Cost Accounting Standards (CAS...

The Improvement of Basic Support and Advance Clarification Skill with Problem Solving

OpenAIRE

Safira, Novi Ayu; Diawati, Chansyanah; Rosilawati, Ila

2013-01-01

The low-creative critical thinking skill of the student is because many schools use low-level abilities in learning. The use of problem solving model in the learning is one of the efforts for practice the critical thinking skill students. This research aimed to describe the problem solving model that are effective in improving the basic support and advance clarification skill. This research using a quasi-experimental methods with Non Equivalent Control Group Design. The sampling technique use...

37 CFR 1.311 - Notice of allowance.

Science.gov (United States)

2010-07-01

... fee, in which case the issue fee and publication fee (§ 1.211(e)) must both be paid within three... notice of allowance will operate as a request to charge the correct issue fee or any publication fee due... incorrect issue fee or publication fee; or (2) A fee transmittal form (or letter) for payment of issue fee...

45 CFR 84.33 - Free appropriate public education.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Free appropriate public education. 84.33 Section..., Elementary, and Secondary Education § 84.33 Free appropriate public education. (a) General. A recipient that operates a public elementary or secondary education program or activity shall provide a free appropriate...

24 CFR 84.20 - Purpose of financial and program management.

Science.gov (United States)

2010-04-01

... and Program Management § 84.20 Purpose of financial and program management. Sections 84.21 through 84.28 prescribe standards for financial management systems, methods for making payments and rules for... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Purpose of financial and program...

75 FR 7577 - Combined Notice of Filings # 1

Science.gov (United States)

2010-02-22

..., LLC, Baltimore Gas and Electric Company, Constellation Pwr Source Generation LLC, Constellation New... Operating Companies FERC Electric Third Revised Volume No. 1 Open Access Transmission Tariff. Filed Date: 02... Numbers: EG10-20-000. Applicants: Northeastern Power Company. Description: Notice of Self-Certification of...

An acidic pectin lyase from Aspergillus niger with favourable efficiency in fruit juice clarification.

Science.gov (United States)

Xu, S X; Qin, X; Liu, B; Zhang, D Q; Zhang, W; Wu, K; Zhang, Y H

2015-02-01

The pectin lyase gene pnl-zj5a from Aspergillus niger ZJ5 was identified and expressed in Pichia pastoris. PNL-ZJ5A was purified by ultrafiltration, anion exchange and gel chromatography. The Km and Vmax values determined using citrus pectin were 0.66 mg ml(-1) and 32.6 μmol min(-1) mg(-1) , respectively. PNL-ZJ5A exhibited optimal activity at 43°C and retained activity over 25-50°C. PNL-ZJ5A was optimally active at pH 5 and effective in apple juice clarification. Compared with controls, PNL-ZJ5A increased the fruit juice yield significantly. Furthermore, PNL-ZJ5A reduced the viscosity of apple juice by 38.8% and increased its transmittance by 86.3%. PNL-ZJ5A combined with a commercial pectin esterase resulted in higher juice volume. © 2014 The Society for Applied Microbiology.

Economic evaluation of schema therapy and clarification-oriented psychotherapy for personality disorders: A multicenter, randomized controlled trial

NARCIS (Netherlands)

Bamelis, L.L.M.; Arntz, A.; Wetzelaer, P.; Verdoorn, R.; Evers, S.M.A.A.

2015-01-01

Purpose: To compare from a societal perspective the cost-effectiveness and cost-utility of schema therapy, clarification-oriented psychotherapy, and treatment as usual for patients with avoidant, dependent, obsessive-compulsive, paranoid, histrionic, and/or narcissistic personality disorder. Method:

42 CFR 84.99 - Man tests; testing conditions; general requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Man tests; testing conditions; general requirements. 84.99 Section 84.99 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing Apparatus § 84.99...

26 CFR 1.508-1 - Notices.

Science.gov (United States)

2010-04-01

... a church, such as a men's or women's organization, religious school, mission society, or youth group... was organized, or before March 22, 1973, whichever comes later. Such notice is filed by submitting a...) of this subdivision or before March 22, 1973, whichever is later, in lieu of the period prescribed in...

75 FR 14589 - Combined Notice of Filings #1

Science.gov (United States)

2010-03-26

... Energy Marketing, LLC. Description: Public Service Company of New Mexico et al. submits Supplement to... as Second Revised Service Agreement No. 1688, effective 2/28/2010 with WM Renewable Energy LLC et al... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 March 18...

EBUS-TBNA for the clarification of PET positive intra-thoracic lymph nodes-an international multi-centre experience

NARCIS (Netherlands)

Rintoul, Robert C.; Tournoy, Kurt G.; El Daly, Hesham; Carroll, Nicholas R.; Buttery, Robert C.; van Kralingen, Klaas; van Meerbeeck, Jan P.; Rabe, Klaus F.; Annema, Jouke T.

2009-01-01

To determine the sensitivity and accuracy of endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) for clarification of the nature of fluorodeoxyglucose-positron emission tomography (FDG) positive hilar and/or mediastinal lymph nodes in patients with (suspected) lung cancer.

Effects of add on PTH(1-84) substitution therapy in hypoparathyroidism: results from a double-blind randomised controlled study

DEFF Research Database (Denmark)

Sikjær, Tanja Tvistholm; Rejnmark, Lars; Mosekilde, Leif

-phosphate levels within the physiological range. Compared with placebo, participants randomised to PTH (1-84) reduced their daily dose of calcium supplements by 68 % (pvitamin D dose by 53% (pneed of calcium supplements...... and 7 were not in need of active vitamin D. With the actual add on therapy there were no change in renal calcium excretion in response to treatment. Compared with placebo, bone mineral density (BMD) decreased significantly at the hip (-1.59 ± 0.57%), lumbar spine (-1.76 ± 1.03%) and whole body (-1...... bone packets. In conclusion, PTH substitution therapy is capable of maintaining normal p-calcium levels with a significantly reduced need for calcium supplements and active vitamin D. In contrast to the effect of PTH(1-84) treatment in patients with osteoporosis, causing an increase in BMD...

45 CFR 1356.84 - Sampling.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Sampling. 1356.84 Section 1356.84 Public Welfare....84 Sampling. (a) The State agency may collect and report the information required in section 1356.83(e) of this part on a sample of the baseline population consistent with the sampling requirements...

Theory-informed design of values clarification methods : A cognitive psychological perspective on patient health-related decision making

NARCIS (Netherlands)

Pieterse, A.H.; de Vries, M.; Kunneman, M.; Stiggelbout, A.M.; Feldman-Stewart, D.

2013-01-01

Healthcare decisions, particularly those involving weighing benefits and harms that may significantly affect quality and/or length of life, should reflect patients' preferences. To support patients in making choices, patient decision aids and values clarification methods (VCM) in particular have

75 FR 40812 - Combined Notice of Filings #1

Science.gov (United States)

2010-07-14

...: POSDEF Power Company, LP; FPL Energy Green Power Wind, LLC; Diablo Winds, LLC; High Winds, LLC; FPL Energy New Mexico Wind, LLC; Blythe Energy, LLC; NextEra Energy Power Marketing, LLC; FPL Energy Cabazon... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 July 2...

77 FR 74200 - Pennsylvania; Amendment No. 1 to Notice of an Emergency Declaration

Science.gov (United States)

2012-12-13

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Internal Agency Docket No. FEMA-3356-EM; Docket ID FEMA-2012-0002] Pennsylvania; Amendment No. 1 to Notice of an Emergency... notice of an emergency declaration for the Commonwealth of Pennsylvania (FEMA-3356-EM), dated October 29...

76 FR 65739 - Pennsylvania; Amendment No. 1 to Notice of an Emergency Declaration

Science.gov (United States)

2011-10-24

... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Internal Agency Docket No. FEMA-3340-EM; Docket ID FEMA-2011-0001] Pennsylvania; Amendment No. 1 to Notice of an Emergency... notice of an emergency declaration for the Commonwealth of Pennsylvania (FEMA-3340-EM), dated September 8...

75 FR 61726 - Combined Notice of Filings #1

Science.gov (United States)

2010-10-06

... submits a Notice of Cancellation of their market-based rate schedule, Electric Rate Schedule FERC 1. Filed...: Palama, LLC submits tariff filing per 35.12: Palama, LLC Baseline Market-Based Rate Tariff Filing to be... Time on Tuesday, October 12, 2010. Docket Numbers: ER10-2811-000. Applicants: Barclays Bank PLC...

76 FR 24045 - Notice of HUD-Held Multifamily Loan Sale (MLS 2011-1)

Science.gov (United States)

2011-04-29

..., the bidder's deposit was non-refundable and was applied toward the purchase price. Deposits were... Commissioner, HUD. ACTION: Notice of sale of mortgage loans. SUMMARY: This notice announces HUD's intention to... INFORMATION: HUD announces its intention to sell in MLS 2011-1 certain unsubsidized mortgage loans (Mortgage...

29 CFR 2590.606-1 - General notice of continuation coverage.

Science.gov (United States)

2010-07-01

... beyond the applicable maximum period, and the plan's requirements applicable to the payment of premiums...) Model notice. The appendix to this section contains a model notice that is intended to assist administrators in discharging the notice obligations of this section. Use of the model notice is not mandatory...

Mammalian Cell Culture Clarification: A Case Study Using Chimeric Anti-CEA Monoclonal Antibodies

Directory of Open Access Journals (Sweden)

Mohamed Ali Abol Hassan

2011-12-01

Full Text Available The extracellular expression of monoclonal antibodies (mAbs in mammalian cell culture provides both opportunities and restrictions for the design of robust harvest and clarification operations. With advances in cell culture media and cell lines, it is now possible to achieve high titers of over 5 g/l for mAbs. However, Mammalian cells are sensitive to breakage due to shear stress that can result in release of proteases and other host cell proteins (HCPs which eventually affects product stability and purity. There is larger number of mAbs undergoing clinical development and it has placed significant importance on platform technologies of process development. Generally, Centrifugation and microfiltration are the primary harvest techniques used in the industry and depth filtration is also used as a step operation on clarification. This study compares the unit operations; centrifugation, microfiltration and depth filtration for maximum recovery of monoclonal antibodies. The results have shown that the depth filtration as more suitable operation for mammalian cell culture clarification since it gives 96% recovery of mAbs in comparison to centrifugation and microfiltration. ABSTRAK: Pengungkapan luar sel dari antibodi monoklon (monoclonal antibodies ((mAbs dalam kultur sel mamalia memberi ruang dan batasan terhadap reka bentuk penuaian yang cekap dan penerangan operasi. Dengan kemajuan dalam media sel kultur dan cell lines (produk yang berupa sel kekal yang digunakan untuk tujuan kajian biologi, kini adalah berkemungkinan untuk memperolehi titer tinggi melebihi 5g/l untuk mAbs [2]. Walaupun begitu, sel mamalia sensitif terhadap retakan disebabkan tegasan ricih yang menyebabkan pengeluaran protease dan hos sel protein yang lain, (host cell proteins (HCPs akhirnya mempengaruhi kestabilan dan keaslian produk. Terdapat mAbs dalam jumlah besar yang masih menjalani pembangunan klinikal dan sesungguhnya ini penting sebagai satu landasan teknologi dalam

The role of G-protein receptor 84 in experimental neuropathic pain.

Science.gov (United States)

Nicol, Louise S C; Dawes, John M; La Russa, Federica; Didangelos, Athanasios; Clark, Anna K; Gentry, Clive; Grist, John; Davies, John B; Malcangio, Marzia; McMahon, Stephen B

2015-06-10

G-protein receptor 84 (GPR84) is an orphan receptor that is induced markedly in monocytes/macrophages and microglia during inflammation, but its pathophysiological function is unknown. Here, we investigate the role of GPR84 in a murine model of traumatic nerve injury. Naive GPR84 knock-out (KO) mice exhibited normal behavioral responses to acute noxious stimuli, but subsequent to partial sciatic nerve ligation (PNL), KOs did not develop mechanical or thermal hypersensitivity, in contrast to wild-type (WT) littermates. Nerve injury increased ionized calcium binding adapter molecule 1 (Iba1) and phosphorylated p38 MAPK immunoreactivity in the dorsal horn and Iba1 and cluster of differentiation 45 expression in the sciatic nerve, with no difference between genotypes. PCR array analysis revealed that Gpr84 expression was upregulated in the spinal cord and sciatic nerve of WT mice. In addition, the expression of arginase-1, a marker for anti-inflammatory macrophages, was upregulated in KO sciatic nerve. Based on this evidence, we investigated whether peripheral macrophages behave differently in the absence of GPR84. We found that lipopolysaccharide-stimulated KO macrophages exhibited attenuated expression of several proinflammatory mediators, including IL-1β, IL-6, and TNF-α. Forskolin-stimulated KO macrophages also showed greater cAMP induction, a second messenger associated with immunosuppression. In summary, our results demonstrate that GPR84 is a proinflammatory receptor that contributes to nociceptive signaling via the modulation of macrophages, whereas in its absence the response of these cells to an inflammatory insult is impaired. Copyright © 2015 Nicol et al.

Advances in post-fermented wine clarification by centrifugal technology

Directory of Open Access Journals (Sweden)

Giacomo Costagli

2016-11-01

Full Text Available Wine clarification processes are deeply determined by complex interaction of wine constituents and application of available technologies as well as use of fining agents. Among others, centrifuge is a consolidated technique applied for many separation duties in the winery. Important advances on improvement of the performance of centrifugal technology have beeen focused on gentle wine treatment, minimal dissolved oxygen and significant reduction of energy consumption helping to dispel old beliefs on a technique considered to be traditional. This paper reviews the development of technology and recent advances on centrifuge improvement and aims to show, through field experimental observation, the importance of removing a portion of particles responsible of haze in the light of very low level of dissolved oxygen and complementarity of alternative recent techniques of wine filtration like cross-flow microfiltration.

42 CFR 84.117 - Gas mask containers; minimum requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Gas mask containers; minimum requirements. 84.117... SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84.117 Gas mask containers; minimum requirements. (a) Gas masks shall be equipped with a substantial...

75 FR 11162 - Combined Notice of Filings #1

Science.gov (United States)

2010-03-10

... Notice of Exempt Wholesale Generator Status of El Cajon Energy, LLC. Filed Date: 03/03/2010. Accession...-1972-011; ER09-832-006; ER10-1-002. Applicants: Elk City Wind, LLC; FPL Energy Cowboy Wind, LLC; FPL Energy Oklahoma Wind, LLC; FPL Energy Sooner Wind, LLC; Gray County Wind Energy, LLC; NextEra Energy...

33 CFR 110.84b - Buffalo, N.Y.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Buffalo, N.Y. 110.84b Section 110... REGULATIONS Special Anchorage Areas § 110.84b Buffalo, N.Y. The area within the Port of Buffalo known as Port of Buffalo Small Boat Harbor commencing at a point on shore at latitude 42°51′05″ N., longitude 78°51...

45 CFR 84.52 - Health, welfare, and other social services.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Health, welfare, and other social services. 84.52..., Welfare, and Social Services § 84.52 Health, welfare, and other social services. (a) General. In providing health, welfare, or other social services or benefits, a recipient may not, on the basis of handicap: (1...

The Effects of Task Clarification, Feedback, and Goal Setting on Student Advisors' Office Behaviors and Customer Service

Science.gov (United States)

Tittelbach, Danielle; DeAngelis, Maureen; Sturmey, Peter; Alvero, Alicia M.

2007-01-01

This study evaluated the effects of feedback, task clarification and goal-setting on office behaviors and customer service of ten undergraduate participants that served as university advisors. A multiple baseline design was implemented across three target behaviors: client greeting, front-desk behaviors, and punctuality. During intervention the…

42 CFR 84.40 - Quality control plans; filing requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Quality control plans; filing requirements. 84.40... Control § 84.40 Quality control plans; filing requirements. As a part of each application for approval or... proposed quality control plan which shall be designed to assure the quality of respiratory protection...

Pedagogical competence and value clarification among health educators.

Science.gov (United States)

Wistoft, Karen

2009-09-01

Individual and social values are increasingly important in health education. This article examines how health educators in Greenland and Denmark engage in value clarification as part of their educational practices. It presents the results of a study of health professionals in a variety of settings, focusing in particular on how development work and experimentation can strengthen their pedagogical competences. The study focuses on belief, reasoning, interpretation and reflection, rather than routines, skills, or ethical rules, and takes a participatory approach that oscillates between dialogical and qualitative empirical methodologies. It observes pedagogical practice in selected settings in Greenland and the municipality of Copenhagen. Within the framework provided by four discourses that appear to organize communication about health, it shows how values became important to the progress of two research-based development projects. On this basis, the article argues that health education can be effectively grounded in the values, perceptions, and experiences of a given population, while being guided by the health educators' biomedical knowledge and educational values.

Clarification of TMI action plan requirements. Technical report

International Nuclear Information System (INIS)

1980-11-01

This document, NUREG-0737, is a letter from D.G. Eisenhut, Director of the Division of Licensing, NRR, to licensees of operating power reactors and applicants for operating licenses forwarding post-TMI requirements which have been approved for implementation. Following the accident at Three Mile Island Unit 2, the NRC staff developed the Action Plan, NUREG-0660, to provide a comprehensive and integrated plan to improve safety at power reactors. Specific items from NUREG-0660 have been approved by the Commission for implementation at reactors. In this NRC report, these specific items comprise a single document which includes additional information about schedules, applicability, method of implementation review, submittal dates, and clarification of technical positions. It should be noted that the total set of TMI-related actions have been collected in NUREG-0660, but only those items that the Commission has approved for implementation to date are included in this document, NUREG-0737

24 CFR 84.52 - Financial reporting.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Financial reporting. 84.52 Section... Financial reporting. (a) The following forms or such other forms as may be approved by OMB are authorized for obtaining financial information from recipients. (1) SF-269 or SF-269A, Financial Status Report...

Fabrication of Al-based composites reinforced with in situ devitrified Al{sub 84}Ni{sub 8.4}Y{sub 4.8}La{sub 1.8}Co{sub 1} particles by hot pressing consolidation

Energy Technology Data Exchange (ETDEWEB)

Yang, Qing, E-mail: buaayq00@gmail.com; Zhang, Yitan; Zhang, Haiping; Zheng, Ruixiao; Xiao, Wenlong; Ma, Chaoli, E-mail: machaoli@buaa.edu.cn

2015-11-05

In this study, Al{sub 84}Ni{sub 8.4}Y{sub 4.8}La{sub 1.8}Co{sub 1} particles reinforced Al-based composites were prepared by hot pressing sintering and subsequent hot extrusion. The glassy powders were produced by gas atomization and then employed to mechanical milling. After hot pressing sintering, the nano-scale intermetallic compounds precipitated from metallic glass matrix due to higher temperature than super-cooled liquid region. The mechanical properties of 2024 alloy were improved by addition of glassy particles. The ultimate compressive stress increased from 482 MPa for 2024 alloy to 545 MPa, 627 MPa and 735 MPa for composites with 20 w.t.% 40 w.t.% and 60 w.t.% glassy powders addition, respectively, together with considerable fracture strain ranging between 2.9% and 13.6%. And the mechanical properties could be predicted by using the Rule of Mixture, which predicts the mechanical properties of the bulks from the volume weighed average of the constituent properties. - Highlights: • The composites are fabricate by hot pressing and extrusion. • The single phase of amorphous alloy is obtained by sieving. • The nano-scale compounds precipitates from glassy matrix. • The compressive strength reaches to the value of 735 MPa. • The strength can fit well with rule of mixture.

78 FR 73854 - Combined Notice of Filings #1

Science.gov (United States)

2013-12-09

... Power Corporation. Description: Notice of Cancellation of Grandfathered Network Integration Transmission... Integration Transmission Service Agreement No. 120 of Niagara Mohawk Power Corporation. Filed Date: 11/26/13...-000. Applicants: KATBRO LLC. Description: Katbro LLC submits notice of cancellation of its market...

29 CFR 825.307 - Authentication and clarification of medical certification for leave taken because of an employee...

Science.gov (United States)

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Authentication and clarification of medical certification... ACT OF 1993 Employee and Employer Rights and Obligations Under the Act § 825.307 Authentication and... authentication. If an employee submits a complete and sufficient certification signed by the health care provider...

Relationships between the physical forms of starch and performance of carbonatation clarification and press filtration at the refinery

Science.gov (United States)

Laboratory studies were conducted to underpin if and how the different physical forms of starch (insoluble or soluble) affected carbonatation clarification and press filtration, by using simulated melt liquors. Carbonatated liquors containing =250 ppm/Brix (USDA starch research method) of total sta...

20 CFR 631.84 - Allowable projects.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Allowable projects. 631.84 Section 631.84... THE JOB TRAINING PARTNERSHIP ACT Disaster Relief Employment Assistance § 631.84 Allowable projects...) Shall be used exclusively to provide employment on projects that provide food, clothing, shelter and...

Pretreatment with ceramic membrane microfiltration in the clarification process of sugarcane juice by ultrafiltration

Directory of Open Access Journals (Sweden)

Priscilla dos Santos Gaschi

2014-04-01

Full Text Available In the present study, the sugar cane juice from COCAFE Mill, was clarified using tubular ceramic membranes (α-Al2O3/TiO2 with pore size of 0.1 and 0.3 µm, and membrane area of 0.005 m2. Experiments were performed in batch with sugar cane juice, in a pilot unit of micro and ultrafiltration using the principle of tangential filtration. The sugar cane juice was settled for one hour and the supernatant was treated by microfiltration. After that, the MF permeate was ultrafiltered. The experiments of micro and ultrafiltration were carried out at 65ºC and 1 bar. The ceramic membranes were able to remove the colloidal particles, producing a limpid permeated juice with color reduction. The clarification process with micro- followed by ultrafiltration produced a good result with an average purity rise of 2.74 units, 99.4% lower turbidity and 44.8% lighter color in the permeate.

76 FR 19347 - Combined Notice of Filings #1

Science.gov (United States)

2011-04-07

...: Notice of Cancellation of Interchange Agreement with LG&E Energy Marketing by Florida Power Corporation...-recertification] listed above, do not institute a proceeding regarding qualifying facility status. A notice of... the FERC Online links at http://www.ferc.gov . To facilitate electronic service, persons with Internet...

DISORGANIZATION, FEAR AND ATTACHMENT: WORKING TOWARDS CLARIFICATION

Science.gov (United States)

2018-01-01

ABSTRACT In 1990, M. Main and J. Solomon introduced the procedures for coding a new “disorganized” infant attachment classification for the Ainsworth Strange Situation procedure (M.D.S. Ainsworth, M. Blehar, E. Waters, & S. Wall, 1978). This classification has received a high degree of interest, both from researchers and from child welfare and clinical practitioners. Disorganized attachment has primarily been understood through the lens of E. Hesse and M. Main's concept of “fright without solution,” taken to mean that an infant experiences a conflict between a desire to approach and flee from a frightening parent when confronted by the Strange Situation. Yet, looking back, it can be observed that the way Hesse and Main's texts were formulated and read has generated confusion; there have been repeated calls in recent years for renewed theory and clarification about the relationship between disorganization and fear. Responding to these calls, this article revisits the texts that introduced the idea of fright without solution, clarifying their claims through articulating more precisely the different meanings of the term fear. This clarified account will then be applied to consideration of pathways to infant disorganized behaviors. PMID:29314076

14 CFR 399.84 - Price advertising.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Price advertising. 399.84 Section 399.84... STATEMENTS STATEMENTS OF GENERAL POLICY Policies Relating to Enforcement § 399.84 Price advertising. The Board considers any advertising or solicitation by a direct air carrier, indirect air carrier, or an...

Development of a promising filtration method for liquid clarification in nuclear facilities

International Nuclear Information System (INIS)

Collins, E.D.; Knauer, J.B.; Byrd, L.A.; Ross, R.G.; Savage, H.C.

1982-01-01

Conclusions reached are that deep beds of diatomaceous earths are especially attractive for clarification of radioactive solutions, or slurries containing insoluble radioactive material, because the diatomaceous material provides a noncompressible medium that is retentive for a wide variety of particle sizes. Also, the diatomaceous material, because of its inorganic composition, is resistant to degradation by radiation from the retained particulate matter. Its silicious character is especially appropriate for conversion to vitrified or cement-type waste forms. This paper studied the use of diatomaceous earth to filter synthetic TMI-2 water, reprocessing dissolver solutions, and zinc bromide solutions (hot-cell shielding)

75 FR 71112 - Combined Notice of Filings #1

Science.gov (United States)

2010-11-22

.... Description: Community Wind North 3 LLC Notice of Self- Certification of Exempt Wholesale Generator Status...: Community Wind North 5 LLC Notice of Self- Certification of Exempt Wholesale Generator Status. Filed Date... III LLC, Grand Ridge Energy IV LLC, Grand Ridge Energy V LLC, Vantage Wind Energy LLC, Beech Ridge...

76 FR 21722 - Combined Notice of Filings #1

Science.gov (United States)

2011-04-18

... Notice of Cancellation of Reactive Power Rate Schedule. Filed Date: 04/07/2011. Accession Number...)(2)(iii): Revisions to the Tariff and OA re Emerg. Load Response Program ``Reporting'' to be... Reactive Rate Schedule Notice of Succession to be effective 3/9/2011. Filed Date: 04/07/2011. Accession...

26 CFR 301.6323(j)-1 - Withdrawal of notice of federal tax lien in certain circumstances.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Withdrawal of notice of federal tax lien in certain circumstances. 301.6323(j)-1 Section 301.6323(j)-1 Internal Revenue INTERNAL REVENUE SERVICE... General Provisions § 301.6323(j)-1 Withdrawal of notice of federal tax lien in certain circumstances. (a...

77 FR 34344 - Circular Welded Non-Alloy Steel Pipe From the Republic of Korea: Final Results of the Antidumping...

Science.gov (United States)

2012-06-11

... of Korea, Mexico, and Venezuela, 61 FR 11608 (March 21, 1996). In accordance with this determination... Proceedings: Assessment of Antidumping Duties, 68 FR 23954 (May 6, 2003) (``Assessment Policy Notice''). This... transaction. See Assessment Policy Notice for a full discussion of this clarification. Cash Deposit...

Utility QA viewpoint: Quality assurance program conforming to 10CFR50, Appendix B and 10CFR71, subpart H

International Nuclear Information System (INIS)

Grodi, D.L.

1987-01-01

The Nuclear Regulatory Commission issued IE Information Notice No. 84-50: ''Clarification of Scope of Quality Assurance Programs for Transport Packages Pursuant to 10CFR50, Appendix B, in June, 1984. The reason for this notice was to eliminate confusion applicable to the quality assurance provisions of Appendix B, 10CFR50 to certain transport packages for which a quality assurance program is required by 10 CFR 71. The purpose of this paper is to provide methodology for establishing, implementing and verifying that all 10CFR71, Subpart H requirements are met with the utility's NRC approved 10CFR50, Appendix B Quality Assurance Program when utilizing a contractor (with a NRC approved Quality Assurance Program for Radioactive Waste Packaging and Transport) providing the radioactive waste solidification, packaging and transport for the utility. Collectively (utility and contractor) the quality assurance programs will meet the applicable regulatory requirements without the necessity of the utility establishing a separate and specific quality assurance program for Packaging and Transport of Radioactive Waste

ALX 111: ALX1-11, parathyroid hormone (1-84) - NPS Allelix, PREOS, PTH, recombinant human parathyroid hormone, rhPTH (1-84).

Science.gov (United States)

2003-01-01

ALX 111 [parathyroid hormone (1-84) - NPS Allelix, recombinant human parathyroid hormone, rhPTH (1-84), PREOS] is a full-length, recombinant human parathyroid hormone. It has potential as an anti-osteoporotic agent, due to its properties as a bone formation stimulant. This profile has been selected from R&D Insight, a pharmaceutical intelligence database produced by Adis International Ltd. It has been recommended that ALX 111 should be given for 1 to 2 years and may be given in combination with an antiresorptive agent, such as estrogen or a bisphosphonate. In December 1999, Allelix Biopharmaceuticals merged with NPS Pharmaceuticals. This combined company is operating as NPS Pharmaceuticals in the US and as NPS Allelix in Canada. The merger has enabled a phase III study of ALX 111 to begin in the US, Europe and South America. NPS harmaceuticals has signed an agreement with Bio-Imaging Technologies, which will provide all image handling and analysis for this trial. Until 1994, Allelix Biopharmaceuticals and Glaxo in Canada were involved in a joint venture to investigate the efficacy of ALX 111 in osteoporosis. Allelix was subsequently, until September 1998, collaborating with Astra of Sweden in developing ALX 111. Astra had acquired exclusive worldwide rights to ALX 111 and was responsible for development of the agent. However, Astra returned all rights to ALX 111 to Allelix as a result of its merger with Zeneca to form AstraZeneca. In December 1999, Allelix Biopharmaceuticals merged with NPS Pharmaceuticals. This combined company is operating as NPS Pharmaceuticals in the US and as NPS Allelix in Canada. The merger has enabled a phase III study of ALX 111 to begin in the US, Europe and South America. The phase III trial of ALX 111 for the treatment of osteoporosis has completed patient enrolment, and phase II trials have been completed in Canada and the Netherlands. The 18-month, phase III, multicentre, placebo-controlled trial (Treatment of Osteoporosis with

Decay of84fRb

International Nuclear Information System (INIS)

Passaro, A.M.P.

1987-01-01

For the first time, low intensity beta ramifications were determined in the decay of 84 Rb to 84 Kr. The methodology and apparatus employed are presented as well as the advantages and experimental array. (A.C.A.S.) [pt

Escherichia coli LF82 differentially regulates ROS production and mucin expression in intestinal epithelial T84 cells: implication of NOX1.

Science.gov (United States)

Elatrech, Imen; Marzaioli, Viviana; Boukemara, Hanane; Bournier, Odile; Neut, Christel; Darfeuille-Michaud, Arlette; Luis, José; Dubuquoy, Laurent; El-Benna, Jamel; My-Chan Dang, Pham; Marie, Jean-Claude

2015-05-01

Increased reactive oxygen species (ROS) production is associated with inflamed ileal lesions in Crohn's disease colonized by pathogenic adherent-invasive Escherichia coli LF82. We investigated whether such ileal bacteria can modulate ROS production by epithelial cells, thus impacting on inflammation and mucin expression. Ileal bacteria from patients with Crohn's disease were incubated with cultured epithelial T84 cells, and ROS production was assayed using the luminol-amplified chemiluminescence method. The gentamicin protection assay was used for bacterial invasion of T84 cell. The expression of NADPH oxidase (NOX) subunits, mucin, and IL-8 was analyzed by quantitative real-time PCR and Western blots. Involvement of NOX and ROS was analyzed using diphenyleneiodonium (DPI) and N-acetylcysteine (NAC). Among different bacteria tested, only LF82 induced an increase of ROS production by T84 cells in a dose-dependent manner. This response was inhibited by DPI and NAC. Heat- or ethanol-attenuated LF82 bacteria and the mutant LF82ΔFimA, which does not express pili type 1 and poorly adheres to epithelial cells, did not induce the oxidative response. The LF82-induced oxidative response coincides with its invasion in T84 cells, and both processes were inhibited by DPI. Also, we observed an increased expression of NOX1 and NOXO1 in response to LF82 bacteria versus the mutant LF82ΔFimA. Furthermore, LF82 inhibited mucin gene expression (MUC2 and MUC5AC) in T84 cells while increasing the chemotactic IL-8 expression, both in a DPI-sensitive manner. Adherent-invasive E. coli LF82 induced ROS production by intestinal NADPH oxidase and altered mucin and IL-8 expression, leading to perpetuation of inflammatory lesions in Crohn's disease.

29 CFR 1918.84 - Bulling cargo.

Science.gov (United States)

2010-07-01

... 29 Labor 7 2010-07-01 2010-07-01 false Bulling cargo. 1918.84 Section 1918.84 Labor Regulations...) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Handling Cargo § 1918.84 Bulling cargo. (a) Bulling cargo shall be done with the bull line led directly from the heel block. However, bulling may be done from the...

Interecotechnics '84

International Nuclear Information System (INIS)

1984-01-01

The Symposium Interekotechnika 84 was held in Bratislava from June 28-29, 1984. The proceedings supplement includes 8 papers of which only 2 were inputted in INIS. The subject area was the use of nuclear analytical methods in monitoring the pollution of environment. (E.S.)

48 CFR 352.234-1 - Notice of earned value management system-pre-award Integrated Baseline Review.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Notice of earned value management system-pre-award Integrated Baseline Review. 352.234-1 Section 352.234-1 Federal Acquisition... provision: Notice of Earned Value Management System—Pre-Award Integrated Baseline Review (October 2008) The...

77 FR 49026 - Agency Information Collection Activities: Comment Request

Science.gov (United States)

2012-08-15

... Register notice (77 FR 30330): Comment: One institutional Financial Official (FO) questioned why it was the... Management and Budget (OMB) for clearance simultaneously with the publication of this second notice. The full...: One institutional CO requested clarification of the ``current degree status''. Did it mean type of...

75 FR 77838 - Circular Welded Non-Alloy Steel Pipe From the Republic of Korea: Preliminary Results of the...

Science.gov (United States)

2010-12-14

..., the Republic of Korea (Korea), Mexico, and Venezuela, and Amendment to Final Determination of Sales at... Duties, 68 FR 23954 (May 6, 2003) (``Assessment Policy Notice''). Based on Hyundai HYSCO's certification... instructions do not alleviate the concerns which the Assessment Policy Notice clarification was intended to...

76 FR 49437 - Certain Circular Welded Non-Alloy Steel Pipe From Mexico: Preliminary Results of Antidumping Duty...

Science.gov (United States)

2011-08-10

... Non-Alloy Steel Pipe from Brazil, the Republic of Korea (Korea), Mexico, and Venezuela and Amendment... 23954 (May 6, 2003) (Assessment Policy Notice). Because ``as entered'' liquidation instructions do not... assessment'' regulation on May 6, 2003. See Assessment Policy Notice. This clarification will apply to POR...

75 FR 8757 - Nebraska Public Power District, Cooper Nuclear Station, Unit 1; Notice of Availability of the...

Science.gov (United States)

2010-02-25

..., Cooper Nuclear Station, Unit 1; Notice of Availability of the Draft Supplement 41 to the Generic... Renewal of Cooper Nuclear Station, Unit 1 Notice is hereby given that the U.S. Nuclear Regulatory... operating license DPR-46 for an additional 20 years of operation for Cooper Nuclear Station, Unit 1 (CNS-1...

Clean Cook Stove Technology for Artisanal Palm Oil Clarification and Biochar Production in Ghana

DEFF Research Database (Denmark)

Dorvlo, Selorm Y.; Addo, Ahmad; Abenney-Mickson, Stephen

the palm fruits) and simultaneously produce heat and biochar. The adopted design procedure was iterative and eight preliminary tests were conducted; each an improvement of the previous stove tested. The best stove configuration was adopted for the design calculations and the final stove fabricated...... with a biochar yield of 5%. A maximum CO emission of 5 ppm was measured. The study showed that the palm oil clarification process with the designed cook stove provided a smokeless work environment, heat and biochar....

Ti-84 Plus graphing calculator for dummies

CERN Document Server

McCalla

2013-01-01

Get up-to-speed on the functionality of your TI-84 Plus calculator Completely revised to cover the latest updates to the TI-84 Plus calculators, this bestselling guide will help you become the most savvy TI-84 Plus user in the classroom! Exploring the standard device, the updated device with USB plug and upgraded memory (the TI-84 Plus Silver Edition), and the upcoming color screen device, this book provides you with clear, understandable coverage of the TI-84's updated operating system. Details the new apps that are available for download to the calculator via the USB cabl

32 CFR 552.84 - Purpose.

Science.gov (United States)

2010-07-01

... 32 National Defense 3 2010-07-01 2010-07-01 true Purpose. 552.84 Section 552.84 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND NATIONAL CEMETERIES... training areas. Uninterrupted military use is vital to maintain and improve the combat readiness of the US...

On the suitability of fast and frugal heuristics for designing values clarification methods in patient decision aids : A critical analysis

NARCIS (Netherlands)

Pieterse, A.H.; de Vries, M.

2013-01-01

Background  Increasingly, patient decision aids and values clarification methods (VCMs) are being developed to support patients in making preference-sensitive health-care decisions. Many VCMs encourage extensive deliberation about options, without solid theoretical or empirical evidence showing that

Acute regulation of circulating parathyroid hormone (PTH) molecular forms by calcium: utility of PTH fragments/PTH(1-84) ratios derived from three generations of PTH assays.

Science.gov (United States)

D'Amour, Pierre; Räkel, Agnès; Brossard, Jean-Hugues; Rousseau, Louise; Albert, Caroline; Cantor, Tom

2006-01-01

The quantitative evaluation of circulating PTH peaks revealed by PTH assays after HPLC separation constitutes the best way to study the behavior of PTH molecular forms, but it is also impractical. The objective of the study was to investigate the regulation of circulating PTH molecular forms by calcium through the use of PTH fragments/PTH (1-84) ratios derived from PTH assays with different specificities before and after HPLC separation of circulating PTH. CaCl2 and Na citrate were infused in eight volunteers. PTH was measured in serum and HPLC fractions at different calcium concentrations in PTH assays reacting with regions 1-2 (CA), 12-18 (T), and 65-69 (C) of the PTH structure. From hypo- to hypercalcemia, the C/CA ratio had the highest range (1.92 to 9.75; P < 0.001), and the C/T ratio had a higher range (1.69 to 6.11; P < 0.01) than the T/CA ratio (1.15 to 1.86). Human (h) PTH (1-84) represented 32.7 and 4.3% of circulating PTH in hypo- and hypercalcemic HPLC profiles, respectively. These numbers were 5 and 0.9% for amino-terminal (N)-PTH, an amino-terminal form of PTH distinct from hPTH (1-84), 7.3 and 6.8% for non-(1-84) PTH or large C-PTH fragments with a partially preserved N structure, and 54.9 and 88.1% for C-PTH fragments missing a N structure. The HPLC C-PTH fragments to hPTH (1-84) ratio had the most extensive range (1.67 to 20.58). Despite their quantitative differences, all ratios identified identical behavior of PTH fragments relative to PTH (1-84). PTH assay ratios are an adequate tool to investigate the modulation of PTH molecular forms, even if all PTH assays show some undesirable cross-reactivity with certain circulating forms of PTH.

DISORGANIZATION, FEAR AND ATTACHMENT: WORKING TOWARDS CLARIFICATION.

Science.gov (United States)

Duschinsky, Robbie

2018-01-01

In 1990, M. Main and J. Solomon introduced the procedures for coding a new "disorganized" infant attachment classification for the Ainsworth Strange Situation procedure (M.D.S. Ainsworth, M. Blehar, E. Waters, & S. Wall, 1978). This classification has received a high degree of interest, both from researchers and from child welfare and clinical practitioners. Disorganized attachment has primarily been understood through the lens of E. Hesse and M. Main's concept of "fright without solution," taken to mean that an infant experiences a conflict between a desire to approach and flee from a frightening parent when confronted by the Strange Situation. Yet, looking back, it can be observed that the way Hesse and Main's texts were formulated and read has generated confusion; there have been repeated calls in recent years for renewed theory and clarification about the relationship between disorganization and fear. Responding to these calls, this article revisits the texts that introduced the idea of fright without solution, clarifying their claims through articulating more precisely the different meanings of the term fear. This clarified account will then be applied to consideration of pathways to infant disorganized behaviors. © 2018 The Authors. Infant Mental Health Journal published by Wiley Periodicals, Inc. on behalf of Michigan Association for Infant Mental Health.

17 CFR 249.10 - Form 1-N for notice registration as a national securities exchange.

Science.gov (United States)

2010-04-01

... registration as a national securities exchange. 249.10 Section 249.10 Commodity and Securities Exchanges... or Exemption of, and Notification of Action Taken by, National Securities Exchanges § 249.10 Form 1-N for notice registration as a national securities exchange. This form shall be used for notice, and...

The Effects of Task Clarification, Visual Prompts, and Graphic Feedback on Customer Greeting and Up-Selling in a Restaurant

Science.gov (United States)

Squires, James; Wilder, David A.; Fixsen, Amanda; Hess, Erica; Rost, Kristen; Curran, Ryan; Zonneveld, Kimberly

2007-01-01

An intervention consisting of task clarification, visual prompts, and graphic feedback was evaluated to increase customer greeting and up-selling in a restaurant. A combination multiple baseline and reversal design was used to evaluate intervention effects. Although all interventions improved performance over baseline, the delivery of graphic…

Thermophysical Properties of GRCop-84

Science.gov (United States)

Ellis, David L.; Keller, Dennis J.; Nathal, Michael (Technical Monitor)

2000-01-01

The thermophysical properties and electrical resistivity of GRCop-84 (Cu - 8 at.% Cr-4 at.% Nb) were measured from cryogenic temperatures to near its melting point. The data were analyzed using weighted regression to determine the properties as a function of temperature and assign appropriate confidence intervals. The results showed that the thermal expansion of GRCop-84 was significantly lower than NARloy-Z (Cu-3 wt. % Ag-0.5 wt. % Zr), the currently used thrust cell liner material. The lower thermal expansion is expected to translate into lower thermally induced stresses and increases in thrust cell liner lives between 2X and 41X over NARloy-Z. The somewhat lower thermal conductivity of GRCop-84 can be offset by redesigning the liners to utilize its much greater mechanical properties. Optimized designs are not expected to suffer from the lower thermal conductivity. Electrical resistivity data, while not central to the primary application, show that GRCop-84 has potential for applications where a combination of good electrical conductivity and strength is required.

27 CFR 6.84 - Point of sale advertising materials and consumer advertising specialties.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Point of sale advertising materials and consumer advertising specialties. 6.84 Section 6.84 Alcohol, Tobacco Products and Firearms....84 Point of sale advertising materials and consumer advertising specialties. (a) General. The act by...

Application of decolourized and partially purified polygalacturonase and α-amylase in apple juice clarification

Directory of Open Access Journals (Sweden)

Tapati Bhanja Dey

2014-01-01

Full Text Available Polygalacturonase and α-amylase play vital role in fruit juice industry. In the present study, polygalacturonase was produced by Aspergillus awamori Nakazawa MTCC 6652 utilizing apple pomace and mosambi orange (Citrus sinensis var mosambi peels as solid substrate whereas, α-amylase was produced from A. oryzae (IFO-30103 using wheat bran by solid state fermentation (SSF process. These carbohydrases were decolourized and purified 8.6-fold, 34.8-fold and 3.5-fold, respectively by activated charcoal powder in a single step with 65.1%, 69.8% and 60% recoveries, respectively. Apple juice was clarified by these decolourized and partially purified enzymes. In presence of 1% polygalacturonase from mosambi peels (9.87 U/mL and 0.4% α-amylase (899 U/mL, maximum clarity (%T660nm = 97.0% of juice was attained after 2 h of incubation at 50 ºC in presence of 10 mM CaCl2. Total phenolic content of juice was reduced by 19.8% after clarification, yet with slightly higher %DPPH radical scavenging property.

Application of decolourized and partially purified polygalacturonase and α-amylase in apple juice clarification.

Science.gov (United States)

Dey, Tapati Bhanja; Banerjee, Rintu

2014-01-01

Polygalacturonase and α-amylase play vital role in fruit juice industry. In the present study, polygalacturonase was produced by Aspergillus awamori Nakazawa MTCC 6652 utilizing apple pomace and mosambi orange (Citrus sinensis var mosambi) peels as solid substrate whereas, α-amylase was produced from A. oryzae (IFO-30103) using wheat bran by solid state fermentation (SSF) process. These carbohydrases were decolourized and purified 8.6-fold, 34.8-fold and 3.5-fold, respectively by activated charcoal powder in a single step with 65.1%, 69.8% and 60% recoveries, respectively. Apple juice was clarified by these decolourized and partially purified enzymes. In presence of 1% polygalacturonase from mosambi peels (9.87 U/mL) and 0.4% α-amylase (899 U/mL), maximum clarity (%T(660 nm) = 97.0%) of juice was attained after 2 h of incubation at 50 °C in presence of 10 mM CaCl2. Total phenolic content of juice was reduced by 19.8% after clarification, yet with slightly higher %DPPH radical scavenging property.

26 CFR 301.6223(e)-1 - Effect of Internal Revenue Service's failure to provide notice.

Science.gov (United States)

2010-04-01

... failed to provide notice to partnership A. Notwithstanding the Internal Revenue Service's notice to the... the partnership through the pass-thru partner. However, this rule does not apply if the indirect...: Example 1. Partnership ABC has as one of its partners, A, a partnership with three partners, X, Y, and Z...

G protein-coupled receptor 84, a microglia-associated protein expressed in neuroinflammatory conditions.

Science.gov (United States)

Bouchard, Caroline; Pagé, Julie; Bédard, Andréanne; Tremblay, Pierrot; Vallières, Luc

2007-06-01

G protein-coupled receptor 84 (GPR84) is a recently discovered member of the seven transmembrane receptor superfamily whose function and regulation are unknown. Here, we report that in mice suffering from endotoxemia, microglia express GPR84 in a strong and sustained manner. This property is shared by subpopulations of peripheral macrophages and, to a much lesser extent, monocytes. The induction of GPR84 expression by endotoxin is mediated, at least in part, by proinflammatory cytokines, notably tumor necrosis factor (TNF) and interleukin-1 (IL-1), because mice lacking either one or both of these molecules have fewer GPR84-expressing cells in their cerebral cortex than wild-type mice during the early phase of endotoxemia. Moreover, when injected intracerebrally or added to microglial cultures, recombinant TNF stimulates GPR84 expression through a dexamethasone-insensitive mechanism. Finally, we show that microglia produce GPR84 not only during endotoxemia, but also during experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. In conclusion, this study reports the identification of a new sensitive marker of microglial activation, which may play an important regulatory role in neuroimmunological processes, acting downstream to the effects of proinflammatory mediators.

7 CFR 160.84 - Identification of shipments.

Science.gov (United States)

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Identification of shipments. 160.84 Section 160.84... STANDARDS FOR NAVAL STORES Sales and Shipments § 160.84 Identification of shipments. The invoice or contract of sale of any naval stores in commerce shall identify and describe the article in accordance with...

75 FR 34980 - Circular Welded Non-Alloy Steel Pipe from the Republic of Korea: Final Results of the Antidumping...

Science.gov (United States)

2010-06-21

... Republic of Korea, Mexico, and Venezuela, 61 FR 11608 (March 21, 1996), pipe certified to the API 5L line... Antidumping Duties, 68 FR 23954 (May 6, 2003) (``Assessment Policy Notice''). This clarification will apply to... there is no rate for the intermediary involved in the transaction. See Assessment Policy Notice for a...

The Explication and Clarification of the Interpretation of the Concepts “Audit” and “Financial Audit”

OpenAIRE

Nazarenko Inna M.

2017-01-01

The aim of the scientific article is explication, clarification of the interpretation of the concepts “audit” and “financial audit” taking into account their functional significance. Based on analyzing fundamental scientific achievements, legislative and normative documents, it is justified that the identification of the concepts “audit” and “financial audit” is inexpedient, since the latter by means of a transformation expands the functional hypostasis of the audit. It is proved that one of ...

77 FR 3742 - India Infrastructure Business Development Mission-Clarification and Amendment

Science.gov (United States)

2012-01-25

... Administration, U.S. and Foreign Commercial Service (CS) is publishing this supplement to the Notice of the India... Basis Background Recruitment for this Mission began in December 2011. Due to the holidays, it has been..., press releases to general and trade media, direct mail, notices by industry trade associations and other...

37 CFR 10.84 - Representing a client zealously.

Science.gov (United States)

2010-07-01

... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Representing a client... Office Code of Professional Responsibility § 10.84 Representing a client zealously. (a) A practitioner shall not intentionally: (1) Fail to seek the lawful objectives of a client through reasonably available...

Comparison of GRCop-84 to Other Cu Alloys with High Thermal Conductivities

Science.gov (United States)

deGroh, Henry C., III; Ellis, David L.; Loewenthal, William S.

2007-01-01

The mechanical properties of six highly conductive copper alloys, GRCop-84, AMZIRC, GlidCop Al-15, Cu-1Cr-0.1Zr, Cu-0.9Cr, and NARloy-Z were compared. Tests were done on as-received hard drawn material, and after a heat treatment designed to simulate a brazing operation at 935 C. In the as-received condition AMZIRC, GlidCop Al-15, Cu- 1Cr-0.1Zr and Cu-0.9Cr had excellent strengths at temperatures below 500 C. However, the brazing heat treatment substantially decreased the mechanical properties of AMZIRC, Cu-1Cr-0.1Zr, Cu-0.9Cr, and NARloy-Z. The properties of GlidCop Al-15 and GRCop-84 were not significantly affected by the heat treatment. Thus there appear to be advantages to GRCop-84 over AMZIRC, Cu-1Cr-0.1Zr, Cu-0.9Cr, and NARloy-Z if use or processing temperatures greater than 500 C are expected. Ductility was lowest in GlidCop Al-15 and Cu-0.9Cr; reduction in area was particularly low in GlidCop Al-15 above 500 C, and as- received Cu-0.9Cr was brittle between 500 and 650 C. Tensile creep tests were done at 500 and 650 C; the creep properties of GRCop-84 were superior to those of brazed AMZIRC, Cu-1Cr- 0.1Zr, Cu-0.9Cr, and NARloy-Z. In the brazed condition, GRCop-84 was superior to the other alloys due to its greater strength and creep resistance (compared to AMZIRC, Cu-1Cr-0.1Zr, Cu-0.9Cr, and NARloy-Z) and ductility (compared to GlidCop Al-15).

33 CFR 110.129a - Apra Harbor, Guam. (Datum: WGS 84)

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Apra Harbor, Guam. (Datum: WGS 84) 110.129a Section 110.129a Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.129a Apra Harbor, Guam. (Datum: WGS 84) (a...

Pectinase production by Aspergillus niger using banana (Musa balbisiana) peel as substrate and its effect on clarification of banana juice.

Science.gov (United States)

Barman, Sumi; Sit, Nandan; Badwaik, Laxmikant S; Deka, Sankar C

2015-06-01

Optimization of substrate concentration, time of incubation and temperature for crude pectinase production from A. niger was carried out using Bhimkol banana (Musa balbisiana) peel as substrate. The crude pectinase produced was partially purified using ethanol and effectiveness of crude and partially purified pectinase was studied for banana juice clarification. The optimum substrate concentration, incubation time and temperature of incubation were 8.07 %, 65.82 h and 32.37 °C respectively, and the polygalacturonase (PG) activity achieved was 6.6 U/ml for crude pectinase. The partially purified enzyme showed more than 3 times of polygalacturonase activity as compared to the crude enzyme. The SDS-PAGE profile showed that the molecular weight of proteins present in the different pectinases varied from 34 to 42 kDa. The study further revealed that highest clarification was achieved when raw banana juice was incubated for 60 min with 2 % concentration of partially purified pectinase and the absorbance obtained was 0.10.

26 CFR 301.6326-1 - Administrative appeal of the erroneous filing of notice of federal tax lien.

Science.gov (United States)

2010-04-01

... tax lien. (a) In general. Any person may appeal to the district director of the district in which a notice of federal tax lien was filed on the property or rights to property of such person for a release... of notice of federal tax lien. 301.6326-1 Section 301.6326-1 Internal Revenue INTERNAL REVENUE...

77 FR 23228 - Notice of Submission for OMB Review; Small Business Innovation Research (SBIR) Program-Phase II...

Science.gov (United States)

2012-04-18

... business concerns to submit a Phase II application for the Small Business Innovation Research (SBIR) Program (CFDA 84.133). This is in response to Public Law 106-554, the ``Small Business Reauthorization Act... DEPARTMENT OF EDUCATION Notice of Submission for OMB Review; Small Business Innovation Research...

HLA-DPβ1 Asp84-Lys69 antigen-binding signature predicts event-free survival in childhood B-cell precursor acute lymphoblastic leukaemia: results from the MRC UKALL XI childhood ALL trial.

Science.gov (United States)

Taylor, G M; Wade, R; Hussain, A; Thompson, P; Hann, I; Gibson, B; Eden, T; Richards, S

2012-07-01

We previously reported that children in the UKALL XI ALL trial with HLA-DP 1 and -DP 3 supertypes had significantly worse event-free survival (EFS) than children with other DP supertypes. As DP 1 and DP 3 share two of four key antigen-binding amino-acid polymorphisms (aspartic acid84-lysine69), we asked whether Asp84-Lys69 or Asp84 alone were independent prognostic indicators in childhood acute lymphoblastic leukemia (ALL). We analysed EFS in 798 UKALL XI patients, stratified by Asp84-Lys69 vs non-Asp84-Lys69, for a median follow-up of 12.5 years. Asp84-Lys69 was associated with a significantly worse EFS than non-Asp84-Lys69 (5-year EFS: Asp84-Lys69: 58.8% (95% CI (confidence of interval): 52.7-64.9%); non-Asp84-Lys69: 67.3% (63.4-71.2%); 2P=0.007). Post-relapse EFS was 10% less in Asp84-Lys69 than non-Asp84-Lys69 patients. EFS was significantly worse (P=0.03) and post-relapse EFS marginally worse (P=0.06) in patients with Asp84 compared with Gly84. These results suggest that Asp84-Lys69 predicted adverse EFS in the context of UKALL XI because of Asp84, and may have influenced post-relapse EFS. We speculate that this may be due to the recruitment of Asp84-Lys69-restricted regulatory T cells in the context of this regimen, leading to the re-emergence of residual disease. However, functional and molecular studies of the prognostic value of this and other HLA molecular signatures in other childhood ALL trials are needed.

26 CFR 301.6036-1 - Notice required of executor or of receiver or other like fiduciary.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Notice required of executor or of receiver or... and Returns Returns and Records § 301.6036-1 Notice required of executor or of receiver or other like.... (b) Executors, administrators, and persons in possession of property of decedent. For provisions...

78 FR 13885 - Notice of HUD-Held Multifamily & Healthcare Loan Sale, Second Offering (MHLS 2013-1)

Science.gov (United States)

2013-03-01

...-708-2625, extension 3927. Hearing- or speech-impaired individuals may call 202-708-4594 (TTY). These... are eligible to submit bids on the Mortgage Loans in the second offering for MHLS 2013- 1. Freedom of... the Freedom of Information Act and all regulations promulgated thereunder. Scope of Notice This notice...

Membrane-associated proteomics of chickpea identifies Sad1/UNC-84 protein (CaSUN1), a novel component of dehydration signaling

Science.gov (United States)

Jaiswal, Dinesh Kumar; Mishra, Poonam; Subba, Pratigya; Rathi, Divya; Chakraborty, Subhra; Chakraborty, Niranjan

2014-02-01

Dehydration affects almost all the physiological processes including those that result in the accumulation of misfolded proteins in the endoplasmic reticulum (ER), which in turn elicits a highly conserved signaling, the unfolded protein response (UPR). We investigated the dehydration-responsive membrane-associated proteome of a legume, chickpea, by 2-DE coupled with mass spectrometry. A total of 184 protein spots were significantly altered over a dehydration treatment of 120 h. Among the differentially expressed proteins, a non-canonical SUN domain protein, designated CaSUN1 (Cicer arietinum Sad1/UNC-84), was identified. CaSUN1 localized to the nuclear membrane and ER, besides small vacuolar vesicles. The transcripts were downregulated by both abiotic and biotic stresses, but not by abscisic acid treatment. Overexpression of CaSUN1 conferred stress tolerance in transgenic Arabidopsis. Furthermore, functional complementation of the yeast mutant, slp1, could rescue its growth defects. We propose that the function of CaSUN1 in stress response might be regulated via UPR signaling.

21 CFR 7.84 - Opportunity for presentation of views before report of criminal violation.

Science.gov (United States)

2010-04-01

... report of criminal violation. 7.84 Section 7.84 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ENFORCEMENT POLICY Criminal Violations § 7.84 Opportunity for presentation of views before report of criminal violation. (a)(1) Except as provided in paragraph (a) (2) and...

Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor.

Science.gov (United States)

Suzuki, Masakatsu; Takaishi, Sachiko; Nagasaki, Miyuki; Onozawa, Yoshiko; Iino, Ikue; Maeda, Hiroaki; Komai, Tomoaki; Oda, Tomiichiro

2013-04-12

G protein-coupled receptor 84 (GPR84) is a putative receptor for medium-chain fatty acids (MCFAs), whose pathophysiological roles have not yet been clarified. Here, we show that GPR84 was activated by MCFAs with the hydroxyl group at the 2- or 3-position more effectively than nonhydroxylated MCFAs. We also identified a surrogate agonist, 6-n-octylaminouracil (6-OAU), for GPR84. These potential ligands and the surrogate agonist, 6-OAU, stimulated [(35)S]GTP binding and accumulated phosphoinositides in a GPR84-dependent manner. The surrogate agonist, 6-OAU, internalized GPR84-EGFP from the cell surface. Both the potential ligands and 6-OAU elicited chemotaxis of human polymorphonuclear leukocytes (PMNs) and macrophages and amplified LPS-stimulated production of the proinflammatory cytokine IL-8 from PMNs and TNFα from macrophages. Furthermore, the intravenous injection of 6-OAU raised the blood CXCL1 level in rats, and the inoculation of 6-OAU into the rat air pouch accumulated PMNs and macrophages in the site. Our results indicate a proinflammatory role of GPR84, suggesting that the receptor may be a novel target to treat chronic low grade inflammation associated-disease.

Clarification of radiation-control regulations for diagnostic x-ray equipment

International Nuclear Information System (INIS)

1989-03-01

The Office of Compliance and Surveillance of the Center for Devices and Radiological Health (CDRH) has received many requests for interpretation of the Federal regulations that relate to diagnostic x-ray equipment. Responses to these requests were originally issued as FDA Compliance Policy Guides, industry-wide letters, and letters to individuals. The document is a compilation of those responses that remain applicable. Guides or opinions that have been withdrawn or are now obsolete because they have been incorporated into the regulations are not included. The document consists of two sections: the General section, which contains information of a general nature; and the Specific section, which contains information specific to particular sections of the Federal Performance Standard for Diagnostic X-ray Equipment (21 CFR 1020.30-32). When the term 'Revised Language' appears in an item heading, it indicates English grammar correction; the term 'Revised' indicates an updated version of the original clarification

50 CFR 679.84 - Rockfish Program recordkeeping, permits, monitoring, and catch accounting.

Science.gov (United States)

2010-10-01

..., monitoring, and catch accounting. 679.84 Section 679.84 Wildlife and Fisheries FISHERY CONSERVATION AND..., permits, monitoring, and catch accounting. (a) Recordkeeping and reporting. See § 679.5(r). (b) Permits... cooperative or rockfish limited access fishery. The requirements under paragraphs (c)(1) through (9) of this...

36 CFR 51.84 - What special terms must I know to understand this part?

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false What special terms must I know to understand this part? 51.84 Section 51.84 Parks, Forests, and Public Property NATIONAL PARK... § 51.84 What special terms must I know to understand this part? To understand this subpart specifically...

STS-84 Insignia

Science.gov (United States)

1996-01-01

The STS-84 emblem depicts the Space Shuttle Atlantis launching into Earth orbit to join the Russian Space Station Mir as part of Phase One of the International Space Station program. The names of the eight astronauts who flew onboard Atlantis, including the two who changed their positions onboard Mir for a long duration flight, are shown along the border of the patch. The STS-84/Mir-23 team will transfer 7,000 pounds of experiments, Station hardware, food and clothing to and from Mir during the five-day period of docking. The Phase One program is represented by the rising Sun and by the Greek letter Phi followed by one star. This sixth Shuttle-Mir docking mission is symbolized by the six stars surrounding the word Mir in Cyrillic characters. Combined, the seven stars symbolize the current configuration of Mir, composed of six modules launched by the Russians and one module brought up by Atlantis on a previous docking flight.

40 CFR 60.84 - Emission monitoring.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Emission monitoring. 60.84 Section 60....84 Emission monitoring. (a) A continuous monitoring system for the measurement of sulfur dioxide... under § 60.13(d), shall be sulfur dioxide (SO2). Method 8 shall be used for conducting monitoring system...

Theory-informed design of values clarification methods: A cognitive psychological perspective on patient health-related decision making

OpenAIRE

Pieterse, A.H.; de Vries, M.; Kunneman, M.; Stiggelbout, A.M.; Feldman-Stewart, D.

2013-01-01

Healthcare decisions, particularly those involving weighing benefits and harms that may significantly affect quality and/or length of life, should reflect patients' preferences. To support patients in making choices, patient decision aids and values clarification methods (VCM) in particular have been developed. VCM intend to help patients to determine the aspects of the choices that are important to their selection of a preferred option. Several types of VCM exist. However, they are often des...

Far infrared near normal specular reflectivity of Nix(SiO2)1-x (x = 1.0, 0.84, 0.75, 0.61, 0.54, 0.28) granular films

KAUST Repository

Massa, Né stor E.; Denardin, Juliano C.; Socolovsky, Leandro M.; Knobel, Marcelo; De La Cruz, Fernando Pablo; Zhang, Xixiang

2010-01-01

of transition metal granular films with different metal fractions against what is known for conducting oxides. Films for Nix(SiO2)1-x (x = 1.0, 0.84, 0.75, 0.61, 0.54, 0.28) were studied by temperature dependent far infrared measurements. While for pure Ni

24 CFR 84.21 - Standards for financial management systems.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Standards for financial management... and Program Management § 84.21 Standards for financial management systems. (a) HUD shall require.... (b) Recipients' financial management systems shall provide for the following: (1) Accurate, current...

76 FR 27649 - HIV/AIDS Bureau Policy Notice 11-01 (Replaces Policy Notice 99-02)

Science.gov (United States)

2011-05-12

... Bureau Policy Notice 11-01 (Replaces Policy Notice 99- 02) AGENCY: Health Resources and Services.../AIDS Bureau (HAB) Policy Notice 99-02 established policies for the use of Ryan White HIV/AIDS Program... and short-term or emergency housing needs. Amendment 1 to Policy Notice 99-02, effective March 27...

21 CFR 1.281 - What information must be in a prior notice?

Science.gov (United States)

2010-04-01

... by truck, bus, or rail, the trip number; (v) For food arriving as containerized cargo by water, air... arrived by truck, bus, or rail, the trip number; (v) For food that arrived as containerized cargo by water... 21 Food and Drugs 1 2010-04-01 2010-04-01 false What information must be in a prior notice? 1.281...

Pregnancy and medical irradiation. ICRP-84; Embarazo e irradiacion medica. ICRP-84

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-07-01

A translation to Spanish of the ICRP document number 84. The exposure to ionising radiation of pregnant patients and radiation workers is a relevant subject in radiation protection, concerning not only the prevention but also the estimation of the associated risks. Great anxiety and unnecessary termination of pregnancies may be the consequences of the lack of correlation between the perception of risks by the pregnant woman and the involved professionals and their real magnitude. The International Commission on Radiation Protection has edited in 2000 the document ICRP 84 'Pregnancy and Medical Irradiation', addressed to medical and sanitary personnel. This document has been written as a practical guide which describes the effects of prenatal exposure to ionising radiation , the dose-thresholds and their relationship with the gestational age. It includes occupationally exposed women, patients undergoing medical procedures and public members. Most of diagnostic procedures properly done do not imply induction of deterministic effects in embryo/fetus. Therapeutical procedures could be associated with significant risks of deterministic effects. Childhood cancer induction is an stochastic effect without threshold and every 'in utero' exposure will increase their probability. With the aim of facilitating the diffusion of this document in the Ibero-American community , the Argentine Society of Radiation Protection (SAR) and the Spanish Society of Radiation Protection (SEPR) have worked together to producing a spanish version of ICRP84 , that is now presented in this publication, authorized by the ICRP.

iagnostic accuracy study comparing total alkaline phosphatase with intact parathyroid hormone 1-84 for the diagnosis of high turnover renal osteodystrophy in chronic renal failure on hemodialysis

Directory of Open Access Journals (Sweden)

Andrés Marcelo Rojas González

2014-09-01

Full Text Available INTRODUCTION High turnover renal osteodystrophy (HTRO is a highly prevalent complication in patients with chronic kidney disease and mineral bone disease (CKD-MBD, causing pain and significant fracture-associated morbidity and mortality. The diagnostic gold standard test is bone biopsy but there are other, more widely available screening tests such as 1-84 intact parathormone (1-84 iPTH and nonspecific markers such as total alkaline phosphatase (tALP. PURPOSE To determine the diagnostic value (ROC curve, predictive values and likelihood ratios of 1-84 iPTH and tALP for HTRO screening. METHODS A diagnostic accuracy study was performed on a sample of CKD-MDB patients, grouping them according to bone biopsy results and analyzing the results of the diagnostic tests as descriptive variables. RESULTS The study group comprised 188 patients with CKD-MDB, 36 of which had biopsy-confirmed HTRO (19.15%. The average age was 50.2 years in the biopsy group, and 53.4 years in the non-biopsy group (p=0.2385, most were male (63.8% and diabetic (80.5%. The mean time in dialysis was 5.02 years in the biopsy group, and 2.61 years for the non-biopsy group (p<0.001. The mean Kt/V was 1.44 in the biopsy group, and 1.40 in the non-biopsy group (p=0.5354. The mean tALP was 398.02 IU/L in the group with HTRO versus 141.76 IU/L in the group without HTRO (p<0.001. The best cut-off value for tALP was 300-350 IU/L with a near 80% post-test probability, but also with a 15-20% probability for HTRO if the test is negative. The mean 1-84 iPTH was 1248.01 pg/ml in the group with HTRO versus 350.76 pg/ml in the group without HTRO (p<0.001. The 1-84 iPTH cut-off reference value of 300 pg/ml was associated with a post-test probability of 30% for HTRO diagnosis and had a lower overall performance. The best cut-off value for iPTH 1-84 was 600 pg/ml with a post-test probability for HTRO of 70% if positive and less than 5% if the test results are negative. DISCUSSION Both markers show

Embelin and its derivatives unravel the signaling, proinflammatory and antiatherogenic properties of GPR84 receptor.

Science.gov (United States)

Gaidarov, Ibragim; Anthony, Todd; Gatlin, Joel; Chen, Xiaohua; Mills, David; Solomon, Michelle; Han, Sangdon; Semple, Graeme; Unett, David J

2018-05-01

GPR84 is an orphan G-protein coupled receptor, expressed on monocytes, macrophages and neutrophils and is significantly upregulated by inflammatory stimuli. The physiological role of GPR84 remains largely unknown. Medium chain fatty acids (MCFA) activate the receptor and have been proposed to be its endogenous ligands, although the high concentrations of MCFAs required for receptor activation generally exceed normal physiological levels. We identified the natural product embelin as a highly potent and selective surrogate GPR84 agonist (originally disclosed in patent application WO2007027661A2, 2007) and synthesized close structural analogs with widely varying receptor activities. These tools were used to perform a comprehensive study of GPR84 signaling and function in recombinant cells and in primary human macrophages and neutrophils. Activation of recombinant GPR84 by embelin in HEK293 cells results in G i/o as well as G12/13-Rho signaling. In human macrophages, GPR84 initiates PTX sensitive Erk1/2 and Akt phosphorylation, PI-3 kinase activation, calcium flux, and release of prostaglandin E2. In addition, GPR84 signaling in macrophages elicits G i Gβγ-mediated augmentation of intracellular cAMP, rather than the decrease expected from G iα engagement. GPR84 activation drives human neutrophil chemotaxis and primes them for amplification of oxidative burst induced by FMLP and C5A. Loss of GPR84 is associated with attenuated LPS-induced release of proinflammatory mediators IL-6, KC-GROα, VEGF, MIP-2 and NGAL from peritoneal exudates. While initiating numerous proinflammatory activities in macrophages and neutrophils, GPR84 also possesses GPR109A-like antiatherosclerotic properties in macrophages. Macrophage receptor activation leads to upregulation of cholesterol transporters ABCA1 and ABCG1 and stimulates reverse cholesterol transport. These data suggest that GPR84 may be a target of therapeutic value and that distinct modes of receptor modulation (inhibition vs

11 CFR 100.84 - Office building for State, local, or district party committees or organizations.

Science.gov (United States)

2010-01-01

... 11 Federal Elections 1 2010-01-01 2010-01-01 false Office building for State, local, or district party committees or organizations. 100.84 Section 100.84 Federal Elections FEDERAL ELECTION COMMISSION GENERAL SCOPE AND DEFINITIONS (2 U.S.C. 431) Exceptions to Contributions § 100.84 Office building for...

Molecular and Macromolecular Changes in Bottle-Aged White Wines Reflect Oxidative Evolution–Impact of Must Clarification and Bottle Closure

Directory of Open Access Journals (Sweden)

Christian Coelho

2018-04-01

Full Text Available Chardonnay wines from Burgundy, obtained from musts with three levels of clarification (Low, Medium and High during two consecutive vintages (2009 and 2010 and for two kinds of closures (screw caps and synthetic coextruded closures were analyzed chemically and sensorially. Three bottles per turbidity level were opened in 2015 in order to assess the intensity of the reductive and/or oxidative aromas (REDOX sensory scores by a trained sensory panel. The chemical analyses consisted in polyphenols and colloids quantification, followed by a proteomic characterization. For the two vintages, the REDOX sensory scores appeared to be driven both by the type of closure and to a lesser extent by the level of must clarification. Vintages and must racking prefermentative operations were also distinguished by chemical analyses. All white wines from the lowest must turbidity had the lowest REDOX sensory scores. Such wines exhibited lower concentrations in tyrosol and grape reaction product and higher concentrations in colloids with relatively low molecular weights. Among these macromolecules, grape proteins were also quantified, two of them exhibiting concentrations in bottled wines, which were statistically correlated to oxidative evolution in white wines.

Research integrity and misconduct: a clarification of the concepts.

Science.gov (United States)

Khanyile, T D; Duma, S; Fakude, L P; Mbombo, N; Daniels, F; Sabone, M S

2006-03-01

The commercialization of research and the ever changing scientific environment has led scholars to shift the focus from promoting research integrity to regulating misconduct. As a result, most literature explains research integrity in terms of avoidance of misconduct. The purpose of the paper is to stimulate reflection and discussion on research integrity and research misconduct. This article explores the meaning of research integrity and research misconduct, and how research integrity can be promoted to ensure safer research and scholarship. We believe that the discussion can help clarify some hazy areas in the research and publication processes, and appreciate some crucial aspects that they may have seen taken for granted. The purpose of this article is to share with the readers some clarification or analysis of the two concepts namely: research integrity and misconduct. The objectives are: (1) To explore and analyse the concepts of research integrity and research misconduct from the educational or developmental perspective and not the legal perspective as others in literature have done. (2) To stimulate the reflection and discussion on strategies to promote research integrity and thus prevent research misconduct Literature review and concept analysis was undertaken to clarify the two concepts. We argue that the two concepts can be viewed along a continuum, i.e. where research integrity ends, research misconduct starts. We also argue that it is the responsibility of the research community at large to always ensure that the scientific ethics balance is maintained throughout the research process to ensure research integrity and avoid research misconduct. We also argue that research integrity is interlinked with morality while misconduct is interlinked with immorality.

Account 1983-84

International Nuclear Information System (INIS)

1984-01-01

Account prepared pursuant to section 3 (4) of the Radiological Protection Act 1970 of the receipts and payments of the National Radiological Protection Board for the year ended 31st March 1984; together with the Report of the Comptroller and Auditor General thereon. (In continuation of House of Commons Paper No. 149 of 1983-84). (U.K.)

46 CFR 167.30-1 - Notice of repairs or alterations required.

Science.gov (United States)

2010-10-01

... Inspection, whenever repairs or alterations are required, or will be made on a nautical school ship. (b) Whenever a nautical school ship is placed upon the dock, it shall be the duty of the master, owner or agent... NAUTICAL SCHOOL SHIPS Repairs or Alterations § 167.30-1 Notice of repairs or alterations required. (a) It...

29 CFR 37.84 - What happens if CRC does not have jurisdiction over a complaint?

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true What happens if CRC does not have jurisdiction over a complaint? 37.84 Section 37.84 Labor Office of the Secretary of Labor IMPLEMENTATION OF THE... Procedures § 37.84 What happens if CRC does not have jurisdiction over a complaint? If CRC does not have...

RECIST 1.1-Update and clarification : From the RECIST committee

NARCIS (Netherlands)

Schwartz, Lawrence H.; Litiere, Saskia; Vries, de Elisabeth G. E.; Ford, Robert; Gwyther, Stephen; Mandrekar, Sumithra; Shankar, Lalitha; Bogaerts, Jan; Chen, Alice; Dancey, Janet; Hayes, Wendy; Hodi, F. Stephen; Hoekstra, Otto S.; Huang, Erich P.; Lin, Nancy; Liu, Yan; Therasse, Patrick; Wolchok, Jedd D.; Seymour, Lesley

The Response Evaluation Criteria in Solid Tumours (RECIST) were developed and published in 2000, based on the original World Health Organisation guidelines first published in 1981. In 2009, revisions were made (RECIST 1.1) incorporating major changes, including a reduction in the number of lesions

US Nuclear Regulatory Commission Human Factors Program Plan. Revision 1

International Nuclear Information System (INIS)

1984-09-01

The purpose of the NRC Human Factors Program Plan (NUREG-0985) is to ensure that proper consideration is given to human factors in the design, operation, and maintenance of nuclear facilities. This revised plan addresses nuclear power plants (NPPs) and describes (1) the technical assistance and research activities planned to provide the technical bases for the resolution of the remaining human factors related tasks described in NUREG-0660, THE NRC Action Plan developed as a result of the TMI-2 Accident, and NUREG-0737, Clarification of TMI Action Plan Requirements; (2) the additional human factors efforts identified during implementation of the Action Plan that should receive NRC attention; (3) conduct of developmental activities specified in NUREG-0985 during FY-83; and (4) the impact of Section 306 of the Nuclear Waste Policy Act of 1982, PL 97-425. The plan represents a systematic and comprehensive approach for addressing human factors concerns important to NPP safety in the FY-84 through FY-86 time frame

42 CFR 84.149 - Type C supplied-air respirator, demand and pressure demand class; minimum requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Type C supplied-air respirator, demand and pressure demand class; minimum requirements. 84.149 Section 84.149 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT... OF RESPIRATORY PROTECTIVE DEVICES Supplied-Air Respirators § 84.149 Type C supplied-air respirator...

46 CFR 35.20-1 - Notice to mariners; aids to navigation-T/OCLB.

Science.gov (United States)

2010-10-01

... Notices to Mariners (Great Lakes Edition), published by the Commander, 9th Coast Guard District, contain... of navigation on the Great Lakes. These notices may be obtained free of charge, by making application to Commander, 9th Coast Guard District. (c) Weekly Notices to Mariners (worldwide coverage) are...

STS-84 oxygen generator for Mir installation

Science.gov (United States)

1997-01-01

In the SPACEHAB Payload Processing Facility, McDonnell Douglas- SPACEHAB technicians prepare a Russian-made oxygen generator for flight in a SPACEHAB Double Module. The oxygen generator, manufactured in Russia by RSC Energia, will be carried aboard the Space Shuttle Atlantis on Mission STS-84 for the Shuttles scheduled docking with the Russian Space Station Mir next month. The nearly 300-pound generator will replace one of two Mir units that have been malfunctioning recently. The generator functions by electrolysis, which separates water into its oxygen and hydrogen components. The hydrogen is vented and the oxygen is used for breathing by the Mir crew. The generator is 4.2 feet in length and 1.4 feet in diameter. STS-84, which is planned to include a Mir crew exchange of astronaut C. Michael Foale for Jerry M. Linenger, is targeted for a May 15 liftoff. It will be the sixth Shuttle-Mir docking.

78 FR 13897 - Final Revision and Publication of the 2012 Form M-1, Notice

Science.gov (United States)

2013-03-01

... DEPARTMENT OF LABOR Employee Benefits Security Administration RIN 1210-AB51 Final Revision and Publication of the 2012 Form M-1, Notice AGENCY: Employee Benefits Security Administration, Department of... revisions to the Form M-1, Report for Multiple Employer Welfare Arrangements (MEWAs) and Certain Entities...

24 CFR 84.45 - Cost and price analysis.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Cost and price analysis. 84.45....45 Cost and price analysis. Some form of cost or price analysis shall be made and documented in the procurement files in connection with every procurement action. Price analysis may be accomplished in various...

21 CFR 522.84 - Beta-aminopropionitrile fumarate.

Science.gov (United States)

2010-04-01

... use in breeding animals since the effects on fertility, pregnancy, or fetal health have not been... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Beta-aminopropionitrile fumarate. 522.84 Section 522.84 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

40 CFR 425.84 - New source performance standards (NSPS).

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false New source performance standards (NSPS). 425.84 Section 425.84 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS LEATHER TANNING AND FINISHING POINT SOURCE CATEGORY Pigskin Subcategory § 425.84 New...

Agonists for G-protein-coupled receptor 84 (GPR84) alter cellular morphology and motility but do not induce pro-inflammatory responses in microglia.

Science.gov (United States)

Wei, Li; Tokizane, Kyohei; Konishi, Hiroyuki; Yu, Hua-Rong; Kiyama, Hiroshi

2017-10-03

Several G-protein-coupled receptors (GPCRs) have been shown to be important signaling mediators between neurons and glia. In our previous screening for identification of nerve injury-associated GPCRs, G-protein-coupled receptor 84 (GPR84) mRNA showed the highest up-regulation by microglia after nerve injury. GPR84 is a pro-inflammatory receptor of macrophages in a neuropathic pain mouse model, yet its function in resident microglia in the central nervous system is poorly understood. We used endogenous, natural, and surrogate agonists for GPR84 (capric acid, embelin, and 6-OAU, respectively) and examined their effect on mouse primary cultured microglia in vitro. 6-n-Octylaminouracil (6-OAU), embelin, and capric acid rapidly induced membrane ruffling and motility in cultured microglia obtained from C57BL/6 mice, although these agonists failed to promote microglial pro-inflammatory cytokine expression. Concomitantly, 6-OAU suppressed forskolin-induced increase of cAMP in cultured microglia. Pertussis toxin, an inhibitor of Gi-coupled signaling, completely suppressed 6-OAU-induced microglial membrane ruffling and motility. In contrast, no 6-OAU-induced microglial membrane ruffling and motility was observed in microglia from DBA/2 mice, a mouse strain that does not express functional GPR84 protein due to endogenous nonsense mutation of the GPR84 gene. GPR84 mediated signaling causes microglial motility and membrane ruffling but does not promote pro-inflammatory responses. As GPR84 is a known receptor for medium-chain fatty acids, those released from damaged brain cells may be involved in the enhancement of microglial motility through GPR84 after neuronal injury.

Molecular and macromolecular changes in bottle-aged white wines reflect oxidative evolution – Impact of must clarification and bottle closure

Science.gov (United States)

Coelho, Christian; Julien, Perrine; Nikolantonaki, Maria; Noret, Laurence; Magne, Mathilde; Ballester, Jordi; Gougeon, Régis D.

2018-04-01

Chardonnay wines from Burgundy, obtained from musts with three levels of clarification (Low, Medium and High) during two consecutive vintages (2009 and 2010) and for two kinds of closures (screw caps and synthetic coextruded closures) were analyzed chemically and sensorially. Three bottles per turbidity level were opened in 2015 in order to assess the intensity of the reductive and/or oxidative aromas (REDOX sensory scores) by a trained sensory panel. The chemical analyses consisted in polyphenols and colloids quantification, followed by a proteomic characterization. For the two vintages, the REDOX sensory scores appeared to be driven both by the type of closure and to a lesser extent by the level of must clarification. Vintages and must racking prefermentative operations were also distinguished by chemical analyses. All white wines from the lowest must turbidity had the lowest REDOX sensory scores. Such wines exhibited lower concentrations in tyrosol and grape reaction product and higher concentrations in colloids with relatively low molecular weights. Among these macromolecules, grape proteins were also quantified, two of them exhibiting concentrations in bottled wines, which were statistically correlated to oxidative evolution in white wines

G protein-coupled receptor 84 controls osteoclastogenesis through inhibition of NF-κB and MAPK signaling pathways.

Science.gov (United States)

Park, Ji-Wan; Yoon, Hye-Jin; Kang, Woo Youl; Cho, Seungil; Seong, Sook Jin; Lee, Hae Won; Yoon, Young-Ran; Kim, Hyun-Ju

2018-02-01

GPR84, a member of the G protein-coupled receptor family, is found predominantly in immune cells, such as macrophages, and functions as a pivotal modulator of inflammatory responses. In this study, we investigated the role of GPR84 in receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation. Our microarray data showed that GPR84 was significantly downregulated in osteoclasts compared to in their precursors, macrophages. The overexpression of GPR84 in bone marrow-derived macrophages suppressed the formation of multinucleated osteoclasts without affecting precursor proliferation. In addition, GPR84 overexpression attenuated the induction of c-Fos and nuclear factor of activated T cells, cytoplasmic 1 (NFATc1), which are transcription factors that are critical for osteoclastogenesis. Furthermore, knockdown of GPR84 using a small hairpin RNA promoted RANKL-mediated osteoclast differentiation and gene expression of osteoclastogenic markers. Mechanistically, GPR84 overexpression blocked RANKL-stimulated phosphorylation of IκBα and three MAPKs, JNK, ERK, and p38. GPR84 also suppressed NF-κB transcriptional activity mediated by RANKL. Conversely, GPR84 knockdown enhanced RANKL-induced activation of IκBα and the three MAPKs. Collectively, our results revealed that GPR84 functions as a negative regulator of osteoclastogenesis, suggesting that it may be a potential therapeutic target for osteoclast-mediated bone-destructive diseases. © 2017 Wiley Periodicals, Inc.

5 CFR 179.211 - Notice of salary offset.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Notice of salary offset. 179.211 Section... COLLECTION STANDARDS Salary Offset § 179.211 Notice of salary offset. (a) Upon receipt of proper... certification as the debtor, a written notice of salary offset. Such notice shall, at a minimum: (1) State that...

77 FR 273 - Combined Notice of Filings #1

Science.gov (United States)

2012-01-04

... Numbers: QF12-120-000. Applicants: The Coca-Cola Company. Description: Form 556--Notice of self-certification of qualifying cogeneration facility status of The Coca-Cola Company. Filed Date: 12/21/2011...

76 FR 54754 - Combined Notice of Filings #1

Science.gov (United States)

2011-09-02

...: Montgomery L'Energia Power Partners LP. Description: Notice of Cancellation of FERC Electric Rate Schedule Tariff of Montgomery L'Energia Power Partners LP. Filed Date: 08/24/2011. Accession Number: 20110824-5095...

75 FR 47299 - Combined Notice of Filings #1

Science.gov (United States)

2010-08-05

..., LLC, Metro Energy, L.L.C., DTE Energy Supply, Inc., Woodland Biomass Power Ltd. Description: Notice of...: ER10-2033-000. Applicants: Duke Energy Ohio, Inc. Description: Duke Energy Ohio, Inc. submits tariff...

78 FR 13101 - No FEAR Act Notice; Notice of Rights and Protections Available Under Federal Antidiscrimination...

Science.gov (United States)

2013-02-26

... No. 1] No FEAR Act Notice; Notice of Rights and Protections Available Under Federal... FEAR Act. The Act requires that federal agencies provide notice to their employees, former employees.... 1214(f). Nothing in the No FEAR Act alters existing laws or permits an agency to take unfounded...

76 FR 57956 - Renewable Energy and Energy Efficiency Executive Business Development Mission; Clarification and...

Science.gov (United States)

2011-09-19

... DEPARTMENT OF COMMERCE International Trade Administration Renewable Energy and Energy Efficiency... the Notice of the Renewable Energy and Energy Efficiency Executive Business Development Mission, 76 FR... for Recruitment and Applications section of the Notice of the Renewable Energy and Energy Efficiency...

78 FR 74157 - Notice of HUD-Held Multifamily Loan Sale (MLS 2014-1)

Science.gov (United States)

2013-12-10

... Street SW., Washington, DC 20410-8000; telephone 202-708-2625, extension 3927. Hearing- or speech... 2014-1. Freedom of Information Act Requests HUD reserves the right, in its sole and absolute discretion... to the Freedom of Information Act and all regulations promulgated thereunder. Scope of Notice This...

75 FR 3721 - Combined Notice of Filings #1

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2010-01-22

... Trading GP. Description: BNP Paribas Energy Trading GP submits a Tariff Amendment and Notice of Succession... Paragraph 36 of October 15 2009 Order on 2010 Business Plans Nad Budgets. Filed Date: 01/11/2010. Accession...

33 CFR 142.84 - Housekeeping.

Science.gov (United States)

2010-07-01

... CONTINENTAL SHELF ACTIVITIES WORKPLACE SAFETY AND HEALTH General Workplace Conditions § 142.84 Housekeeping..., footwear and flooring designed to reduce slipping substantially may be used instead of keeping the drill...

GPR84 sustains aberrant β-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis.

Science.gov (United States)

Dietrich, Philipp A; Yang, Chen; Leung, Halina H L; Lynch, Jennifer R; Gonzales, Estrella; Liu, Bing; Haber, Michelle; Norris, Murray D; Wang, Jianlong; Wang, Jenny Yingzi

2014-11-20

β-catenin is required for establishment of leukemic stem cells (LSCs) in acute myeloid leukemia (AML). Targeted inhibition of β-catenin signaling has been hampered by the lack of pathway components amenable to pharmacologic manipulation. Here we identified a novel β-catenin regulator, GPR84, a member of the G protein-coupled receptor family that represents a highly tractable class of drug targets. High GPR84 expression levels were confirmed in human and mouse AML LSCs compared with hematopoietic stem cells (HSCs). Suppression of GPR84 significantly inhibited cell growth by inducing G1-phase cell-cycle arrest in pre-LSCs, reduced LSC frequency, and impaired reconstitution of stem cell-derived mixed-lineage leukemia (MLL) AML, which represents an aggressive and drug-resistant subtype of AML. The GPR84-deficient phenotype in established AML could be rescued by expression of constitutively active β-catenin. Furthermore, GPR84 conferred a growth advantage to Hoxa9/Meis1a-transduced stem cells. Microarray analysis demonstrated that GPR84 significantly upregulated a small set of MLL-fusion targets and β-catenin coeffectors, and downregulated a hematopoietic cell-cycle inhibitor. Altogether, our data reveal a previously unrecognized role of GPR84 in maintaining fully developed AML by sustaining aberrant β-catenin signaling in LSCs, and suggest that targeting the oncogenic GPR84/β-catenin signaling axis may represent a novel therapeutic strategy for AML. © 2014 by The American Society of Hematology.

76 FR 6607 - Combined Notice of Filings #1

Science.gov (United States)

2011-02-07

...: Blackstone Wind Farm LLC; Blackstone Wind Farm II LLC; High Trail Wind Farm LLC; Meadow Lake Wind Farm LLC... Farm, LLC. Description: Notice of non-material change in status of Blackstone Wind Farm LLC. Filed Date...

78 FR 23243 - Combined Notice of Filings #1

Science.gov (United States)

2013-04-18

...-000 Applicants: BayWa r.e. Mozart, LLC Description: Notice of Self-Certification of Exempt Wholesale Generator Status of BayWa r.e. Mozart, LLC. Filed Date: 4/10/13 Accession Number: 20130410-5093 Comments Due...

Production of slow particle in 1.7 AGeV 84Kr induced emulsion interaction

International Nuclear Information System (INIS)

Li Huiling; Zhang Donghai; Li Xueqin; Jia Huiming

2008-01-01

The production of slow particle in 1.7 AGeV 84 Kr induced emulsion interaction was studied. The experimental results show that the average multiplicity of black, grey and heavily ionized track particle increases with the increase of impact centrality and target size. The average multiplicity of grey track particle and heavily ionized track particle increases with the increase of the number of black track particle. The average multiplicity of heavily ionized track particle increases with the increase of the number of grey track particle, but average multiplicity of black track particle increases with the increase of the number of grey track particle and then saturated. The average multiplicity of grey track particle increases with the increase of the number of heavily ionized track particle, but average multiplicity of black track particle increases with the increase of the number of heavily ionized track particle and then saturated. Those experimental results can be well explained by using the nuclear impact geometry model. (authors)

77 FR 34457 - Pipeline Safety: Mechanical Fitting Failure Reports

Science.gov (United States)

2012-06-11

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No... notice provides clarification to owners and operators of gas distribution pipeline facilities when... of a gas distribution pipeline facility to file a written report for any mechanical fitting failure...

77 FR 57563 - Combined Notice Of Filings #1

Science.gov (United States)

2012-09-18

.... Applicants: New York Independent System Operator, Inc., Niagara Mohawk Power Corporation. Description.... Take notice that the Commission received the following electric reliability filings: Docket Numbers: RR12-13-000. Applicants: North American Electric Reliability Corporation. Description: Update to...

78 FR 14350 - Notice of Single Family Loan Sales (SFLS 2013-1)

Science.gov (United States)

2013-03-05

...-708- 2625, extension 3927. Hearing- or speech-impaired individuals may call 202-708-4594 (TTY). These... backing Ginnie Mae mortgage-backed securities extinguished and terminated by Ginnie Mae. Freedom of... Freedom of Information Act and all regulations promulgated thereunder. Scope of Notice This notice applies...

28 CFR 16.84 - Exemption of Immigration Appeals System.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Exemption of Immigration Appeals System... MATERIAL OR INFORMATION Exemption of Records Systems Under the Privacy Act § 16.84 Exemption of Immigration...) Decisions of the Board of Immigration Appeals (JUSTICE/BIA-001). This exemption applies only to the extent...

Learner-Generated Noticing Behavior by Novice Learners: Tracing the Effects of Learners' L1 on Their Emerging L2

Science.gov (United States)

Park, Eun Sung

2013-01-01

This study examines novice learners' self-generated input noticing approaches and strategies. It is motivated by previous research on input enhancement which yielded insights that learners are naturally prone to notice certain aspects of L2 input on their own without any external means to channel their attention. Two L1 groups (Japanese and…

76 FR 11256 - Notice of HUD-Held Healthcare Loan Sale (HCLS 2011-1)

Science.gov (United States)

2011-03-01

...-8000; telephone 202-708-2625, extension 3927. Hearing- or speech-impaired individuals may call 202-708... to determine whether they are eligible to submit bids on the Mortgage Loans in HCLS 2011-1. Freedom... pursuant to the Freedom of Information Act and all regulations promulgated thereunder. Scope of Notice This...

48 CFR 49.607 - Delinquency notices.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Delinquency notices. 49... MANAGEMENT TERMINATION OF CONTRACTS Contract Termination Forms and Formats 49.607 Delinquency notices. The formats of the delinquency notices in this section may be used to satisfy the requirements of 49.402-3...

75 FR 35011 - Combined Notice of Filings #1

Science.gov (United States)

2010-06-21

... Processes Manual Incorporating Proposed Revisions to the Reliability Standards Development Process. Filed..., June 21, 2010. Take notice that the Commission received the following electric reliability filings: Docket Numbers: RR10-12-000. Applicants: North American Electric Reliability Corp. Description: Petition...

A Low-Temperature Electron Microscopy and Electron Diffraction Study of La1.84Sr0.16CuO4

Science.gov (United States)

Onozuka, Takashi; Omori, Mamoru; Hirabayashi, Makoto; Syono, Yasuhiko

1987-10-01

A high-Tc superconducting compound, La1.84Sr0.16CuO4, has been investigated by electron microscopy and electron diffraction in the range from 10 K to ambient temperature. The tetragonal K2NiF4-type structure undergoes an orthorhombic distortion below about 130 K. In the low-temperature phase, extra diffraction spots and twin lamellae are observed reversibly on cooling and heating in situ. Based on the observed results, a plausible structure model with orthorhombic distortion is proposed.

31 CFR 315.84 - Payment to certain institutions.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Payment to certain institutions. 315.84 Section 315.84 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued..., for example, “Shriners' Hospital for Crippled Children, St. Louis, MO, by William A. Smith...

Clarification? Yes! Standarization? No. Or: What Kind of Cooperation for the Sociology of Culture?

Science.gov (United States)

Krause, Monika

2016-01-01

Christian Smith's paper "The Incoherence of 'Culture' in American Sociology" is a valuable provocation that can prompt us to reflect on the role of concepts and on the role of agreement on the definition of concepts in scientific research. In this comment paper, I raise questions about Smith's empirical expectation that sociologists should agree on a concept of culture based on debates in the sociology of science. I also suggest that in terms of the future agenda for the sociology of culture, we should distinguish between dialogue and clarification on the one hand, which I agree is needed, and standardization on the other hand, which seems incompatible with open-minded empirical research. Rather than work on agreement on what culture is, we might work on clarifying relevant distinctions among dimensions of culture.

76 FR 36528 - Combined Notice of Filings #1

Science.gov (United States)

2011-06-22

...: Dominion Energy Marketing, Inc., Dominion Nuclear Connecticut, Inc., Dominion Energy Kewaunee, Inc... filings, the notices of self-certification [or self-recertification] listed above, do not institute a... encourages electronic submission of protests and interventions in lieu of paper, using the FERC Online links...

31 CFR 353.84 - Payment to certain institutions.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Payment to certain institutions. 353.84 Section 353.84 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued...' Hospital for Crippled Children, St. Louis, MO, by William A. Smith, Superintendent”, or “St. Mary's Roman...

Identification and Structural Characterization of I84C and I84A Mutations That Are Associated with High-Level Resistance to Human Immunodeficiency Virus Protease Inhibitors and Impair Viral Replication▿

Science.gov (United States)

Mo, Hongmei; Parkin, Neil; Stewart, Kent D.; Lu, Liangjun; Dekhtyar, Tatyana; Kempf, Dale J.; Molla, Akhteruzzaman

2007-01-01

Two novel human immunodeficiency virus protease mutations, I84C and I84A, were identified in patient isolates. The mutants with I84C displayed high-level resistance (median, at least 56-fold) to nelfinavir and saquinavir, but the majority remained susceptible to lopinavir. In contrast, isolates with the I84A mutation exhibited ≥33-fold median increased levels of resistance to nelfinavir, indinavir, amprenavir, ritonavir, lopinavir, saquinavir, and atazanavir. Isolates with the I84A or I84C mutation tended to be more resistant than the isolates with the I84V mutation. Modeling of the structure of the mutant proteases indicated that the I84V, I84C, and I84A mutations all create unoccupied volume in the active site, with I84A introducing the greatest change in the accessible surface area from that of the wild-type structure. PMID:17101675

76 FR 30934 - Combined Notice of Filings #1

Science.gov (United States)

2011-05-27

... 19, 2011. Docket Numbers: EC11-84-000. Applicants: Montgomery L'Energia Power Partners LP, Tanner... Montgomery L'Energia Power Partners LP, et. al. Filed Date: 05/23/2011. Accession Number: 20110523-5016...

76 FR 57725 - Combined Notice of Filings #1

Science.gov (United States)

2011-09-16

... for Disposition of Jurisdictional Facilities and Request for Expedition and Certain Waivers of Black... Management Company, LLC. Description: Thornwood Management Company LLC submits a notice of cancellation under..., 2011. Docket Numbers: ER11-4467-000. Applicants: ISO New England Inc. Description: ISO New England Inc...

75 FR 41843 - Combined Notice of Filings #1

Science.gov (United States)

2010-07-19

... Service and Interconnection Agreement with Monterey Regional Waste Management District. Filed Date: 07/07...-1749-000. Applicants: ISO New England Inc. Description: Request of ISO New England, Inc for limited... qualifying facility filings, the notices of self-certification [or self-recertification] listed above, do not...

78 FR 70032 - Combined Notice of Filings #1

Science.gov (United States)

2013-11-22

.... Applicants: Florida Power & Light Company. Description: FPL Errata to the NITSA No. 162 Reallocation of.... ET 12/4/13. Docket Numbers: ER14-394-000. Applicants: Ethical Electric, Inc. Description: Ethical.... Docket Numbers: ER14-396-000. Applicants: Southern California Edison Company. Description: Notice of...

Agonists for G-protein-coupled receptor 84 (GPR84) alter cellular morphology and motility but do not induce pro-inflammatory responses in microglia

OpenAIRE

Wei, Li; Tokizane, Kyohei; Konishi, Hiroyuki; Yu, Hua-Rong; Kiyama, Hiroshi

2017-01-01

Background Several G-protein-coupled receptors (GPCRs) have been shown to be important signaling mediators between neurons and glia. In our previous screening for identification of nerve injury-associated GPCRs, G-protein-coupled receptor 84 (GPR84) mRNA showed the highest up-regulation by microglia after nerve injury. GPR84 is a pro-inflammatory receptor of macrophages in a neuropathic pain mouse model, yet its function in resident microglia in the central nervous system is poorly understood...

A low-temperature electron microscopy and electron diffraction study of La1.84Sr0.16CuO4

International Nuclear Information System (INIS)

Onozuka, Takashi; Omori, Mamoru; Hirabayashi, Makoto; Syono, Yasuhiko

1987-01-01

A high-T c superconducting compound, La 1.84 Sr 0.16 CuO 4 , has been investigated by electron microscopy and electron diffraction in the range from 10 K to ambient temperature. The tetragonal K 2 NiF 4 -type structure undergoes an orthorhombic distortion below about 130 K. In the low-temperature phase, extra diffraction spots and twin lamellae are observed reversibly on cooling and heating in situ. Based on the observed results, a plausible structure model with orthorhombic distortion is proposed. (author)

17 CFR 240.19h-1 - Notice by a self-regulatory organization of proposed admission to or continuance in membership or...

Science.gov (United States)

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Notice by a self-regulatory... Notice by a self-regulatory organization of proposed admission to or continuance in membership or... statutory disqualification. (1) Any self-regulatory organization proposing, conditionally or unconditionally...

76 FR 62790 - Combined Notice of Filings #1

Science.gov (United States)

2011-10-11

... Tuesday, October 18, 2011. Docket Numbers: ER11-4651-000. Applicants: Ford Motor Company. Description: Notice of Termination of Ford Motor Company. Filed Date: 09/27/2011. Accession Numbers: 20110927-5136... England Power Company. Description: New England Power Company submits tariff filing per 35.17(b...

75 FR 61739 - Combined Notice of Filings #1

Science.gov (United States)

2010-10-06

.... Applicants: Champion Energy Marketing, LLC. Description: Champion Energy Marketing, LLC submits tariff filing... filings, the notices of self-certification [or self-recertification] listed above, do not institute a... submission of protests and interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov...

76 FR 46791 - Combined Notice of Filings #1

Science.gov (United States)

2011-08-03

... Trading and Marketing, LLC, Duke Energy Vermillion II, LLC, Duke Energy Washington II, LLC, Happy Jack...] listed above, do not institute a proceeding regarding qualifying facility status. A notice of self... the FERC Online links at http://www.ferc.gov . To facilitate electronic service, persons with Internet...

75 FR 61742 - Combined Notice of Filings #1

Science.gov (United States)

2010-10-06

...- 1255-004. Applicants: ArcLight Energy Marketing, LLC, Oak Creek Wind Power, LLC, Coso Geothermal Power...] listed above, do not institute a proceeding regarding qualifying facility status. A notice of self... the FERC Online links at http://www.ferc.gov . To facilitate electronic service, persons with Internet...

75 FR 42730 - Combined Notice of Filings #1

Science.gov (United States)

2010-07-22

..., 2010. Docket Numbers: ER10-1778-000. Applicants: EWO Marketing, Inc. Description: EWO Marketing, Inc... institute a proceeding regarding qualifying facility status. A notice of self-certification [or self... electronic submission of protests and interventions in lieu of paper, using the FERC Online links at http...

76 FR 13608 - Combined Notice of Filings #1

Science.gov (United States)

2011-03-14

... Corporation, FirstLight Power Resources Management, LLC, GDF SUEZ Energy Marketing NA, Inc., Green Mountain... institute a proceeding regarding qualifying facility status. A notice of self-certification [or self... electronic submission of protests and interventions in lieu of paper, using the FERC Online links at http...

77 FR 47831 - Combined Notice of Filings #1

Science.gov (United States)

2012-08-10

... Corporation for Approval of an Interpretation to Reliability Standard CIP-004-4--Personnel and Training. Filed... Due: 5 p.m. ET 8/23/12. Take notice that the Commission received the following electric reliability filings. Docket Numbers: RD12-5-000. Applicants: North American Electric Reliability Corporation...

76 FR 41186 - Salmonella Verification Sampling Program: Response to Comments on New Agency Policies and...

Science.gov (United States)

2011-07-13

... Service [Docket No. FSIS-2008-0008] Salmonella Verification Sampling Program: Response to Comments on New Agency Policies and Clarification of Timeline for the Salmonella Initiative Program (SIP) AGENCY: Food... Federal Register notice (73 FR 4767- 4774), which described upcoming policy changes in the FSIS Salmonella...

78 FR 56217 - Steel Threaded Rod from India: Postponement of Preliminary Determination of Countervailing Duty...

Science.gov (United States)

2013-09-12

... rental space, freight charges, airfare and advertising. The deadline for completion of the preliminary..., the preliminary determination is due the next business day, i.e., November 25, 2013. See Notice of Clarification: Application of ``Next Business Day'' Rule for Administrative Determination Deadlines Pursuant to...

Beer Clarification by Novel Ceramic Hollow-Fiber Membranes: Effect of Pore Size on Product Quality.

Science.gov (United States)

Cimini, Alessio; Moresi, Mauro

2016-10-01

In this work, the crossflow microfiltration performance of rough beer samples was assessed using ceramic hollow-fiber (HF) membrane modules with a nominal pore size ranging from 0.2 to 1.4 μm. Under constant operating conditions (that is, transmembrane pressure difference, TMP = 2.35 bar; feed superficial velocity, v S = 2.5 m/s; temperature, T = 10 °C), quite small steady-state permeation fluxes (J * ) of 32 or 37 L/m 2 /h were achieved using the 0.2- or 0.5-μm symmetric membrane modules. Both permeates exhibited turbidity beer quality parameters. Moreover, it exhibited J * values of the same order of magnitude of those claimed for the polyethersulfone HF membrane modules currently commercialized. The 1.4-μm asymmetric membrane module yielded quite a high steady-state permeation flux (196 ± 38 L/m 2 /h), and a minimum decline in permeate quality parameters, except for the high levels of turbidity at room temperature and chill haze. In the circumstances, such a membrane module might be regarded as a real valid alternative to conventional powder filters on condition that the resulting permeate were submitted to a final finishing step using 0.45- or 0.65-μm microbially rated membrane cartridges prior to aseptic bottling. A novel combined beer clarification process was thus outlined. © 2016 Institute of Food Technologists®.

76 FR 59769 - Clarification on the Division 1.1 Fireworks Approvals Policy

Science.gov (United States)

2011-09-27

... issuing the EX approval. While APA Standard 87-1 references two instances where Division 1.1 fireworks may... test laboratory if the firework device is manufactured in accordance with APA Standard 87-1 (IBR, see... certify that the firework device conforms to the APA Standard 87-1 and that the descriptions and technical...

78 FR 61942 - Combined Notice of Filings #1

Science.gov (United States)

2013-10-07

...-Certification Of Exempt Wholesale Generator Status Of Mountain Wind Power, LLC. Filed Date: 9/26/13. Accession...: Mountain Wind Power, LLC. Description: Notice Of Self-Certification Of Exempt Wholesale Generator Status Of... Winds, LLC, FPL Energy Cabazon Wind, LLC, FPL Energy Green Power Wind, LLC, FPL Energy Montezuma Wind...

75 FR 51451 - Combined Notice of Filings # 1

Science.gov (United States)

2010-08-20

... & Trading, LP; GP Big Island, LLC; Brunswick Cellulose, Inc.; Georgia-Pacific Cedar Springs LLC; Georgia...-Pacific Toledo LLC; Leaf River Cellulose, LLC. Description: Notice of Non-material Change in Status... submission of protests and interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov...

78 FR 29128 - Combined Notice of Filings #1

Science.gov (United States)

2013-05-17

...-2495- 004; ER12-2496-004. Applicants: Bangor Hydro Electric Company, Emera Energy Services, Inc., Emera... Marketing Company, Electric Energy, Inc., Midwest Electric Power, Inc., AmerenEnergy Medina Valley Cogen, L.... Description: Supplement to April 22, 2013 Notice of Change in Status of Bangor Hydro Electric Company, et al...

76 FR 67165 - Combined Notice of Filings #1

Science.gov (United States)

2011-10-31

... Thursday, November 10, 2011. Docket Numbers: ER12-141-000. Applicants: NAP Trading and Marketing, Inc. Description: NAP Trading and Marketing, Inc submits Notice of Cancellation of Market-Based Rate Tariff to be... of Affiliate Restrictions to be effective 10/20/2011. Filed Date: 10/20/2011. Accession Number...

76 FR 39862 - Combined Notice of Filings #1

Science.gov (United States)

2011-07-07

... Operating Company, LLC, Dynegy Power Marketing, Inc., Casco Bay Energy Company, LLC, Dynegy Marketing and... filings, the notices of self-certification [or self-recertification] listed above, do not institute a... submission of protests and interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov...

76 FR 3622 - Combined Notice of Filings #1

Science.gov (United States)

2011-01-20

..., NexEra Energy Power Marketing, LLC. Description: NextEra Energy Entities Notification of Non-Material... filings, the notices of self-certification [or self-recertification] listed above, do not institute a... submission of protests and interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov...

76 FR 19986 - Combined Notice of Filings #1

Science.gov (United States)

2011-04-11

...: ER10-2614-004. Applicants: ENMAX Energy Marketing, Inc. Description: ENMAX Energy Marketing Inc... filings, the notices of self-certification [or self-recertification] listed above, do not institute a... submission of protests and interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov...

Study of new materials for use as flooded filter media in waste water treatment; Estudio de nuevos materiales como soporte en filtros inundados en la depuracion de aguas residuales

Energy Technology Data Exchange (ETDEWEB)

Zamorano, M.; Hontoria, E. [Universidad de Granada, (Spain)

1998-06-01

The purpose of this study was to investigate pulverized brick taken from brick factories and recycled plastic used to cover crops as supported beds in submerged bi filters for the purification of residual water, which also permit the re-used of recycled or waste products and the clarification and improvement of the effluent flow from the filter. The study of this landfills shows that the ceramic efficiency was 92% COD-removal and 91% SS-removal, with secondary clarification. The study of recycled plastic shows that the efficiency was 88% COD-removal and 84% SS-removal, without secondary clarification. Although the functioning of the system with these materials have not improved 100%, this study has opened up a new field of investigation that will perfect the system and materials. (Author) 10 refs.

76 FR 799 - Publication of Year 2010 Form M-1 With Electronic Filing Option, Notice

Science.gov (United States)

2011-01-06

... DEPARTMENT OF LABOR Employee Benefits Security Administration Publication of Year 2010 Form M-1 With Electronic Filing Option, Notice AGENCY: Employee Benefits Security Administration, Department of... Employer Welfare Arrangements and Certain Entities Claiming Exception. It is generally identical to the...

76 FR 43681 - Combined Notice of Filings #1

Science.gov (United States)

2011-07-21

... Marketing, LLC, Milford Wind Corridor Phase I, LLC, Milford Wind Corridor Phase II, LLC, Stetson Wind II... filings, the notices of self-certification [or self-recertification] listed above, do not institute a... submission of protests and interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov...

76 FR 28264 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Science.gov (United States)

2011-05-16

... Effectiveness of Proposed Rule Change Relating to the Strategy Fee Cap and Clarifications to the CBOE Fees... Chicago Board Options Exchange, Incorporated (``CBOE'' or ``Exchange'') proposes to amend its strategy fee... Statutory Basis for, the Proposed Rule Change 1. Purpose The Exchange currently caps market-maker and broker...

Clarification of sodium silicate solutions derived from diatomites, to improve their industrial expectations

International Nuclear Information System (INIS)

Aguilar Cantillano, Eduardo

2000-01-01

solutions of soluble silicates synthesized have been clarified in Costa Rica from diatomite in almost 50% of their initial coloration. Clarification and removal of iron oxides have been achieved in a higher order of 50% m/m expressed as Fe 2 O 3 . Activated carbon treatment has clarified the scope of [31-57]%, but not significantly decreases the iron content. The application of NaClO to 3% m/m clarifies the scope of [28-51]%, and reduced iron by 48% m/m. The land alone has been shown that is not very effective filter to clarify, [0-14]%, but is effective for the stripping of iron by 68% m/m. Other procedures are effective in clarifying the scope of [42-51]% and reduced the amount of iron in the field of [48-66]%. The synthesis of soluble glasses is possible to clarify for conditioning with commercial purposes diverse, treatment methodologies and analytical control, simple and economical. (author) [es

42 CFR 84.157 - Airflow resistance test; Type C supplied-air respirator, pressure-demand class; minimum...

Science.gov (United States)

2010-10-01

... test; Type C supplied-air respirator, pressure-demand class; minimum requirements. (a) The static... 42 Public Health 1 2010-10-01 2010-10-01 false Airflow resistance test; Type C supplied-air respirator, pressure-demand class; minimum requirements. 84.157 Section 84.157 Public Health PUBLIC HEALTH...

42 CFR 84.156 - Airflow resistance test; Type C supplied-air respirator, demand class; minimum requirements.

Science.gov (United States)

2010-10-01

... C supplied-air respirator, demand class; minimum requirements. (a) Inhalation resistance shall not... 42 Public Health 1 2010-10-01 2010-10-01 false Airflow resistance test; Type C supplied-air respirator, demand class; minimum requirements. 84.156 Section 84.156 Public Health PUBLIC HEALTH SERVICE...

42 CFR 85.6 - Advance notice of visits.

Science.gov (United States)

2010-10-01

... investigation. Advance notice will not be given when, in the judgment of the NIOSH officer, giving such notice..., advance notice will be given by NIOSH to the employer. Upon the request of the employer, NIOSH will inform... 42 Public Health 1 2010-10-01 2010-10-01 false Advance notice of visits. 85.6 Section 85.6 Public...

7 CFR 3015.84 - Request for advance or reimbursement.

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Request for advance or reimbursement. 3015.84 Section 3015.84 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER, DEPARTMENT OF AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Financial Reporting...

75 FR 51990 - Combined Notice of Filings #1

Science.gov (United States)

2010-08-24

...-1225-009; ER09- 1321-005. Applicants: Blue Canyon Windpower II LLC, Cloud County Wind Farm, LLC, Blue... Ohio, Inc et al submits filing as next of their proposed move from Midwest ISO to PJM following the... the entity making the filing has determined the facility named in the notice meets the applicable...

20 CFR 336.5 - Notice to employee.

Science.gov (United States)

2010-04-01

... DURATION OF NORMAL AND EXTENDED BENEFITS Normal Benefits § 336.5 Notice to employee. The Board will notify... will be exhausted. Such notice will include information about the availability of extended benefits... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Notice to employee. 336.5 Section 336.5...

76 FR 38089 - Federal Acquisition Regulation; Organizational Conflicts of Interest

Science.gov (United States)

2011-06-29

... Councils) and the Office of Federal Procurement Policy (OFPP), in consultation with the Office of Government Ethics (OGE). This proposed rule was preceded by an Advance Notice of Proposed Rulemaking (ANPR..., Procurement Analyst, at (202) 501-2658, for clarification of content. For information pertaining to status or...

77 FR 56698 - Air Traffic Procedures Advisory Committee

Science.gov (United States)

2012-09-13

...The FAA is issuing this notice to advise the public that a meeting of the Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification, and upgrading of terminology and procedures.

78 FR 66098 - Air Traffic Procedures Advisory Committee

Science.gov (United States)

2013-11-04

...The FAA is issuing this notice to advise the public that a meeting of the Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification, and upgrading of terminology and procedures.

75 FR 22892 - Air Traffic Procedures Advisory Committee

Science.gov (United States)

2010-04-30

...The FAA is issuing this notice to advise the public that a meeting of the Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification, and upgrading of terminology and procedures.

76 FR 59481 - Air Traffic Procedures Advisory Committee

Science.gov (United States)

2011-09-26

...The FAA is issuing this notice to advise the public that a meeting of the Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification, and upgrading of terminology and procedures.

77 FR 2603 - Air Traffic Procedures Advisory Committee

Science.gov (United States)

2012-01-18

...The FAA is issuing this notice to advise the public that a meeting of the Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification, and upgrading of terminology and procedures.

78 FR 2711 - Air Traffic Procedures Advisory Committee

Science.gov (United States)

2013-01-14

...The FAA is issuing this notice to advise the public that a meeting of the Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification, and upgrading of terminology and procedures.

76 FR 27168 - Air Traffic Procedures Advisory Committee

Science.gov (United States)

2011-05-10

...The FAA is issuing this notice to advise the public that a meeting of the Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification, and upgrading of terminology and procedures.

75 FR 63255 - Air Traffic Procedures Advisory Committee Meeting

Science.gov (United States)

2010-10-14

...The FAA is issuing this notice to advise the public that a meeting of the Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification, and upgrading of terminology and procedures.

42 CFR 84.145 - Motor-operated blower test; minimum requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Motor-operated blower test; minimum requirements... Supplied-Air Respirators § 84.145 Motor-operated blower test; minimum requirements. (a) Motor-operated... connection between the motor and the blower shall be so constructed that the motor may be disengaged from the...

Improved control of sucrose losses and clarified juice turbidity with lime saccharate in hot lime clarification of sugarcane juice and other comparisons with milk of lime

Science.gov (United States)

A comparative investigation of adding milk of lime (MOL) versus lime saccharate (SACCH) in hot lime clarification of juice at a U.S. sugarcane factory was undertaken to quantify performance across the 2009 processing season after a preliminary factory study in 2008. SACCH was prepared by adding hyd...

78 FR 13669 - Notice of Debarment

Science.gov (United States)

2013-02-28

... Fred Spies Mellon & Spies 312 E. College Street, Suite 216 Iowa City, IA 52240 Re: Notice of Debarment... Initiation of Debarment Proceeding, 27 FCC Rcd 12311 (Enf. Bur. 2012) (Attachment 1) (Suspension Notice). \\3...

49 CFR 27.15 - Notice.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Notice. 27.15 Section 27.15 Transportation Office of the Secretary of Transportation NONDISCRIMINATION ON THE BASIS OF DISABILITY IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE General § 27.15 Notice. (a) A recipient shall take...

78 FR 8504 - Combined Notice of Filings #1

Science.gov (United States)

2013-02-06

...; ER10-2488-006 Applicants: Avenal Park LLC, Sand Drag LLC, Sun City Project LLC, Eurus Combine Hills I... Power Pool, Inc. Description: Revisions to Attachment X, Article 3 and Appendix E to be effective 3/30... New England Inc. and The City of Holyoke Gas and Electric Department submit a Notice of Cancellation...

77 FR 23705 - Combined Notice of Filings #1

Science.gov (United States)

2012-04-20

... Agreement SCE--RE Victor Phelan Solar One LLC to be effective 4/12/2012. Filed Date: 4/11/12. Accession...-000. Applicants: EGP Stillwater Solar, LLC. Description: EGP Stillwater Solar, LLC Notice of Change in.... ET 5/2/12. Docket Numbers: ER12-1517-000. Applicants: Energia Sierra Juarez U.S., LLC, San Diego Gas...

78 FR 49503 - Combined Notice of Filings #1

Science.gov (United States)

2013-08-14

... Notice of Succession and MBR Tariff Revisions to be effective 8/3/2013. Filed Date: 8/2/13. Accession...: ER13-2106-000. Applicants: NedPower Mount Storm, LLC. Description: New Baseline--NedPower MBR Tariff to... MBR Wholesale Power Sale Tariff to be effective 8/5/2013. Filed Date: 8/2/13. Accession Number...

78 FR 39722 - Combined Notice of Filings #1

Science.gov (United States)

2013-07-02

... Solar, LLC. Description: Notice of Change in Status of the EDF-RE MBR Companies. Filed Date: 6/21/13.... Docket Numbers: ER13-1747-000. Applicants: eBay Inc. Description: eBay Inc. MBR Application and Initial MBR Tariff to be effective 8/26/2013. Filed Date: 6/21/13. Accession Number: 20130621-5118. Comments...

40 CFR 763.84 - General local education agency responsibilities.

Science.gov (United States)

2010-07-01

... exterminators) who may come in contact with asbestos in a school are provided information regarding the... 40 Protection of Environment 30 2010-07-01 2010-07-01 false General local education agency responsibilities. 763.84 Section 763.84 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC...

Penambahan Natrium Bikarbonat 8,4% pada Lidokain 2% untuk Mengurangi Nyeri Saat Infiltrasi Anestetik Lokal

Directory of Open Access Journals (Sweden)

Doni Arief Rahmansyah

2014-04-01

Full Text Available Local anesthetic infiltration in the area of epidural injections using lidocaine can cause pain. This research was done in June–July 2013, in Dr. Hasan Sadikin Hospital, to determine the effectiveness of adding 8.4% sodium bicarbonate to lidocaine HCl 2 % with 1:10 ratio. This was a double-blind randomized control study involving 44 patients undergoing surgery with epidural techniques. Subjects were divided into two groups, the experimental group ( LB was given 2% lidocaine HCl with sodium bicarbonate 8.4% 1:10 ratio as a local anestetich while the control group (L was given lidocaine 2%. Numeric rating scale (NRS was assessed during infiltration. Data was analyzed using chi-squere test, t-test and Mann-Whitney Test , with 95% confidence level and 94% strength tes and considered significant if p0.05. In conclusion, alkalinization of 2% lidocaine HCl by addition of 8.4% sodium bicarbonate with 1:10 ratio has an effect in reducing NRS.

The Re-evaluation of 84Rb decay data

International Nuclear Information System (INIS)

Huang Xiaolong; Zhou Chunmei

1996-01-01

The 84 Rb is an important radionuclide and its decay data are fundamental data in nuclear applications. The decay data for 84 Rb were re-evaluated. The energies and intensities of γ rays and their internal conversion coefficients, energies and intensities of Auger electrons, conversion electrons and x-rays, were recommended. The decay scheme was also given. The balance of radiation rays intensities and energies was checked. (9 tabs., 2 figs.)

18 CFR 157.9 - Notice of application and notice of schedule for environmental review.

Science.gov (United States)

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Notice of application and notice of schedule for environmental review. 157.9 Section 157.9 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR CERTIFICATES OF PUBLIC...

49 CFR 28.111 - Notice.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Notice. 28.111 Section 28.111 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION § 28.111 Notice. The Department shall...

SurR9C84A protects and recovers human cardiomyocytes from hypoxia induced apoptosis

Energy Technology Data Exchange (ETDEWEB)

Ashok, Ajay [Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research (NLIMBR), School of Medicine (SoM), Faculty of Health, Centre for Molecular and Medical Research - C-MMR, Deakin University, Waurn Ponds, Victoria 3216 (Australia); Department of Pathology, Case Western Reserve University, 2103 Cornell Rd. WRB 5128, Cleveland, OH 44106-7288 (United States); Kanwar, Jagat Rakesh [Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research (NLIMBR), School of Medicine (SoM), Faculty of Health, Centre for Molecular and Medical Research - C-MMR, Deakin University, Waurn Ponds, Victoria 3216 (Australia); Krishnan, Uma Maheswari [Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), School of Chemical & Biotechnology (SCBT), SASTRA University, Thanjavur 613401 (India); Kanwar, Rupinder Kaur, E-mail: rupinder.kanwar@deakin.edu.au [Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research (NLIMBR), School of Medicine (SoM), Faculty of Health, Centre for Molecular and Medical Research - C-MMR, Deakin University, Waurn Ponds, Victoria 3216 (Australia)

2017-01-01

Survivin, as an anti-apoptotic protein and a cell cycle regulator, is recently gaining importance for its regenerative potential in salvaging injured hypoxic cells of vital organs such as heart. Different strategies are being employed to upregulate survivin expression in dying hypoxic cardiomyocytes. We investigated the cardioprotective potential of a cell permeable survivin mutant protein SurR9C84A, for the management of hypoxia mediated cardiomyocyte apoptosis, in a novel and clinically relevant model employing primary human cardiomyocytes (HCM). The aim of this research work was to study the efficacy and mechanism of SurR9C84A facilitated cardioprotection and regeneration in hypoxic HCM. To mimic hypoxic microenvironment in vitro, well characterized HCM were treated with 100 µm (48 h) cobalt chloride to induce hypoxia. Hypoxia induced (HI) HCM were further treated with SurR9C84A (1 µg/mL) in order to analyse its cardioprotective efficacy. Confocal microscopy showed rapid internalization of SurR9C84A and scanning electron microscopy revealed the reinstatement of cytoskeleton projections in HI HCM. SurR9C84A treatment increased cell viability, reduced cell death via, apoptosis (Annexin-V assay), and downregulated free cardiac troponin T and MMP-9 expression. SurR9C84A also upregulated the expression of proliferation markers (PCNA and Ki-67) and downregulated mitochondrial depolarization and ROS levels thereby, impeding cell death. Human Apoptosis Array further revealed that SurR9C84A downregulated expression of pro-apoptotic markers and augmented expression of HSPs and HTRA2/Omi. SurR9C84A treatment led to enhanced levels of survivin, VEGF, PI3K and pAkt. SurR9C84A proved non-toxic to normoxic HCM, as validated through unaltered cell proliferation and other marker levels. Its pre-treatment exhibited lesser susceptibility to hypoxia/damage. SurR9C84A holds a promising clinical potential for human cardiomyocyte survival and proliferation following hypoxic injury

HSB 84A pumping test

Energy Technology Data Exchange (ETDEWEB)

Maloney, W.

2000-03-06

Two constant discharge, multiple well pumping tests were performed in the Congaree aquifer at the H-Area seepage basins during the weeks of April 30 through May 11. The purpose of the tests was to collect information that might determine the source of groundwater contamination in the Congaree aquifer and to estimate the hydraulic parameters of the aquifer. Transmissivity estimates from data collected in Test One ranged from 1,644 ft{sup 2}/day to 2,253 ft{sup 2}/day with an average of 2,013 ft{sup 2}/day and from 1,812 ft{sup 2}/day to 2,562 ft{sup 2}/day with an average of 2,269 ft{sup 2}/day in Test Two. Some leakage through the confining bed was apparent in the vicinity of observation well HSB 69A. This report includes the data collected, the analyses, results and interpretation of the pumping tests performed at HSB 84A. It should serve as a good baseline for future studies on the subject of contaminant migration in the Congaree aquifer on the Savannah River Site.

HSB 84A pumping test

International Nuclear Information System (INIS)

Maloney, W.

2000-01-01

Two constant discharge, multiple well pumping tests were performed in the Congaree aquifer at the H-Area seepage basins during the weeks of April 30 through May 11. The purpose of the tests was to collect information that might determine the source of groundwater contamination in the Congaree aquifer and to estimate the hydraulic parameters of the aquifer. Transmissivity estimates from data collected in Test One ranged from 1,644 ft 2 /day to 2,253 ft 2 /day with an average of 2,013 ft 2 /day and from 1,812 ft 2 /day to 2,562 ft 2 /day with an average of 2,269 ft 2 /day in Test Two. Some leakage through the confining bed was apparent in the vicinity of observation well HSB 69A. This report includes the data collected, the analyses, results and interpretation of the pumping tests performed at HSB 84A. It should serve as a good baseline for future studies on the subject of contaminant migration in the Congaree aquifer on the Savannah River Site

78 FR 53426 - Expansion of Foreign-Trade Zone 84; Houston, Texas

Science.gov (United States)

2013-08-29

... 84; Houston, Texas Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as..., the Port of Houston Authority, grantee of Foreign-Trade Zone 84, submitted an application to the Board for authority to expand FTZ 84 to include a site in Brazos County, Texas, adjacent to the Houston...

42 CFR 84.159 - Man tests for gases and vapors; supplied-air respirators; general performance requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Man tests for gases and vapors; supplied-air respirators; general performance requirements. 84.159 Section 84.159 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES...

39 CFR 6.3 - Notice of meetings.

Science.gov (United States)

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Notice of meetings. 6.3 Section 6.3 Postal Service UNITED STATES POSTAL SERVICE THE BOARD OF GOVERNORS OF THE U.S. POSTAL SERVICE MEETINGS (ARTICLE VI) § 6.3 Notice of meetings. The Chairman or the members of the Board may give the notice required under...

31 CFR 50.91 - Notice to Congress.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Notice to Congress. 50.91 Section 50... PROGRAM Cap on Annual Liability § 50.91 Notice to Congress. Pursuant to section 103(e)(3) of the Act, the Secretary shall provide an initial notice to Congress within 15 days of the certification of an act of...

The President's Report, 1983-84.

Science.gov (United States)

Bok, Derek

The 1983-84 annual report of the President of Harvard University to members of the Board of Overseers addresses the advantages and disadvantages of the utilization of new technologies by a university, comments on the instructional uses of computers (including computer assisted instruction (CAI)) and video technology, and cites specific examples in…

76 FR 32188 - Hatch Solar Energy Center 1, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Science.gov (United States)

2011-06-03

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3635-000] Hatch Solar Energy Center 1, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Hatch Solar Energy Center 1, LLC's application for market-based rate authority, with an accompanying...

76 FR 44322 - Copper Mountain Solar 1, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2011-07-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-4055-000] Copper Mountain Solar 1, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Copper Mountain Solar 1, LLC's application for market-based rate authority, with an accompanying rate...

24 CFR 84.46 - Procurement records.

Science.gov (United States)

2010-04-01

... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards § 84... for lack of competition when competitive bids or offers are not obtained; and (c) Basis for award cost or price. ...

Biological treatment: potential reusing of recycled plastics from grenhouses; La depuracin biolgica: posible reutilizacin de plsticos reciclados procedentes de invernaderos

Energy Technology Data Exchange (ETDEWEB)

Zamorano, M.; Hontaria, E. [Universidad de Granada (Spain)

1997-12-31

The purpose of this study was to investigate recycled plastic used to cover crops as support beds in submerged biofilters for the purification of residual water, which also permit the re-used of recycled or waste products and the clarification and improvement of the effluent flow from the filter. The recycled plastic shows that the efficiency was 88% COD-removal and 84% SS-removal, without secondary clarification. The functioning of the system with this material has not improved 100%, this study has opened up a new field of investigation that will perfect the system and materials. (Author) 10 refs.

21 CFR 500.84 - Conditions for approval of the sponsored compound.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Conditions for approval of the sponsored compound. 500.84 Section 500.84 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Used in Food-Producing Animals § 500.84 Conditions for approval of the sponsored compound. (a) On the...

26 CFR 301.6330-1 - Notice and opportunity for hearing prior to levy.

Science.gov (United States)

2010-04-01

... receipt requested, to the taxpayer's last known address. For further guidance regarding the definition of... validity of the CDP Notice. Q-A10. What if the taxpayer does not receive the CDP Notice because the IRS did... or employee and the taxpayer, or the taxpayer's representative, to hold a face-to-face meeting. A CDP...

30 CFR 817.84 - Coal mine waste: Impounding structures.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Coal mine waste: Impounding structures. 817.84... ACTIVITIES § 817.84 Coal mine waste: Impounding structures. New and existing impounding structures constructed of coal mine waste or intended to impound coal mine waste shall meet the requirements of § 817.81...

40 CFR 86.601-84 - Applicability.

Science.gov (United States)

2010-07-01

... Auditing of New Light-Duty Vehicles, Light-Duty Trucks, and Heavy-Duty Vehicles § 86.601-84 Applicability... of the section number. A section remains in effect for subsequent model years until it is superseded...

Design and Synthesis of 2-Alkylpyrimidine-4,6-diol and 6-Alkylpyridine-2,4-diol as Potent GPR84 Agonists.

Science.gov (United States)

Liu, Yang; Zhang, Qing; Chen, Lin-Hai; Yang, Hui; Lu, Wei; Xie, Xin; Nan, Fa-Jun

2016-06-09

A series of alkylpyrimidine-4,6-diol derivatives were designed and synthesized as novel GRP84 agonists based on a high-throughput screening (HTS) hit 1. 6-Nonylpyridine-2,4-diol was identified as the most potent agonist of GPR84 reported so far, with an EC50 of 0.189 nM. These novel GPR84 agonists will provide valuable tools for the study of the physiological functions of GPR84.

22 CFR 231.15 - Notice.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Notice. 231.15 Section 231.15 Foreign Relations... WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUBLIC LAW 108-11-STANDARD TERMS AND CONDITIONS § 231.15 Notice. Any communication to USAID pursuant to this Guarantee shall be in writing in the English language...

77 FR 34033 - Public Utility District No. 1 of Douglas County; Notice of Authorization for Continued Project...

Science.gov (United States)

2012-06-08

... District No. 1 of Douglas County; Notice of Authorization for Continued Project Operation On May 27, 2010, the Public Utility District No. 1 of Douglas County, licensee for the Wells Hydroelectric Project... regulations thereunder. The Wells Hydroelectric Project is located on the Columbia River in Douglas, Okanogan...

Pregnancy and medical irradiation. ICRP-84

International Nuclear Information System (INIS)

2001-01-01

A translation to Spanish of the ICRP document number 84. The exposure to ionising radiation of pregnant patients and radiation workers is a relevant subject in radiation protection, concerning not only the prevention but also the estimation of the associated risks. Great anxiety and unnecessary termination of pregnancies may be the consequences of the lack of correlation between the perception of risks by the pregnant woman and the involved professionals and their real magnitude. The International Commission on Radiation Protection has edited in 2000 the document ICRP 84 'Pregnancy and Medical Irradiation', addressed to medical and sanitary personnel. This document has been written as a practical guide which describes the effects of prenatal exposure to ionising radiation , the dose-thresholds and their relationship with the gestational age. It includes occupationally exposed women, patients undergoing medical procedures and public members. Most of diagnostic procedures properly done do not imply induction of deterministic effects in embryo/fetus. Therapeutical procedures could be associated with significant risks of deterministic effects. Childhood cancer induction is an stochastic effect without threshold and every 'in utero' exposure will increase their probability. With the aim of facilitating the diffusion of this document in the Ibero-American community , the Argentine Society of Radiation Protection (SAR) and the Spanish Society of Radiation Protection (SEPR) have worked together to producing a spanish version of ICRP84 , that is now presented in this publication, authorized by the ICRP

34 CFR 303.403 - Prior notice; native language.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Prior notice; native language. 303.403 Section 303.403... TODDLERS WITH DISABILITIES Procedural Safeguards General § 303.403 Prior notice; native language. (a... file a complaint and the timelines under those procedures. (c) Native language. (1) The notice must be...

33 CFR 325.3 - Public notice.

Science.gov (United States)

2010-07-01

... for both protection and utilization of important resources. The benefit which reasonably may be... national security.” (d) Distribution of public notices. (1) Public notices will be distributed for posting... concerned Federal agencies, to local, regional and national shipping and other concerned business and...

78 FR 65321 - Notice of Meetings

Science.gov (United States)

2013-10-31

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Agency for Healthcare Research and Quality Notice of Meetings AGENCY: Agency for Healthcare Research and Quality (AHRQ), HHS. ACTION: Notice of Five AHRQ...) 5. Healthcare Information Technology Research (HITR) Date: October 31-November 1, 2013 (Open from 8...

42 CFR 84.1155 - Filters used with canisters and cartridges; location; replacement.

Science.gov (United States)

2010-10-01

...; location; replacement. 84.1155 Section 84.1155 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH... Efficiency Respirators and Combination Gas Masks § 84.1155 Filters used with canisters and cartridges; location; replacement. (a) Particulate matter filters used in conjunction with a canister or cartridge...

75 FR 76710 - Combined Notice of Filings No. 1

Science.gov (United States)

2010-12-09

...: Paradise Solar Urban Renewal, L.L.C. Description: Notice of Self-Certification of Exempt Wholesale Generator Status of Paradise Solar Urban Renewal, L.L.C. Filed Date: 11/23/2010. Accession Number: 20101123... on Tuesday, December 14, 2010. Docket Numbers: ER11-2020-001. Applicants: Domtar Paper Company, LLC...

75 FR 39225 - Combined Notice of Filings No. 1

Science.gov (United States)

2010-07-08

... Gas and Electric Company. Description: Notice of Termination of Certain Agreements with Big Creek... settlement procedures for the Meter Data Error Correction Request etc. Filed Date: 06/23/2010. Accession..., DC. There is an eSubscription link on the Web site that enables subscribers to receive e-mail...

75 FR 40821 - Public Utility District No. 1 of Douglas County; Notice of Settlement Agreement and Soliciting...

Science.gov (United States)

2010-07-14

... District No. 1 of Douglas County; Notice of Settlement Agreement and Soliciting Comments July 7, 2010. Take...: Public Utility District No. 1 of Douglas County, Washington. e. Location: The existing project is located at river mile 515.6 on the Columbia River in Chelan, Douglas, and Okanogan Counties in central...

28 CFR 16.204 - Public notice.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Public notice. 16.204 Section 16.204 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Public Observation of Parole Commission Meetings § 16.204 Public notice. (a) Requirements. Every open meeting and...

Two UGT84 Family Glycosyltransferases Catalyze a Critical Reaction of Hydrolyzable Tannin Biosynthesis in Pomegranate (Punica granatum).

Science.gov (United States)

Ono, Nadia N; Qin, Xiaoqiong; Wilson, Alexander E; Li, Gang; Tian, Li

2016-01-01

Hydrolyzable tannins (HTs) play important roles in plant herbivore deterrence and promotion of human health. A critical step in HT production is the formation of 1-O-galloyl-β-D-glucopyranoside (β-glucogallin, ester-linked gallic acid and glucose) by a UDP-glucosyltransferase (UGT) activity. We cloned and biochemically characterized four candidate UGTs from pomegranate (Punica granatum), of which only UGT84A23 and UGT84A24 exhibited β-glucogallin forming activities in enzyme assays. Although overexpression and single RNAi knockdown pomegranate hairy root lines of UGT84A23 or UGT84A24 did not lead to obvious alterations in punicalagin (the prevalent HT in pomegranate) accumulation, double knockdown lines of the two UGTs resulted in largely reduced levels of punicalagins and bis-hexahydroxydiphenyl glucose isomers. An unexpected accumulation of galloyl glucosides (ether-linked gallic acid and glucose) was also detected in the double knockdown lines, suggesting that gallic acid was utilized by an unidentified UGT activity for glucoside formation. Transient expression in Nicotiana benthamiana leaves and immunogold labeling in roots of pomegranate seedlings collectively indicated cytosolic localization of UGT84A23 and UGT84A24. Overall, functional characterization and localization of UGT84A23 and UGT84A24 open up opportunities for further understanding the regulatory control of HT metabolism in plants and its coordination with other biochemical pathways in the metabolic network.

The selective dopamine uptake inhibitor, D-84, suppresses cocaine self-administration, but does not occasion cocaine-like levels of generalization.

Science.gov (United States)

Batman, Angela M; Dutta, Aloke K; Reith, Maarten E A; Beardsley, Patrick M

2010-12-01

A successful replacement pharmacotherapy for treating cocaine dependency would likely reduce cocaine's abuse, support a low abuse liability, overlap cocaine's subjective effects, and have a long duration of action. Inhibitors with varying selectivity at the dopamine transporter (DAT) have approximated these properties. The objective of the present study was to characterize the behavioural effects of an extremely selective DAT inhibitor, (+) trans-4-(2-Benzhydryloxyethyl)-1-(4-fluorobenzyl) piperadin-3-ol (D-84), a 3-hydroxy substituted piperidine derivative of GBR-12935, for its cocaine-like discriminative stimulus effects, its effects on cocaine self-administration, and for its own self-administration. During cocaine discrimination tests, cocaine occasioned the 10 mg/kg cocaine training stimulus with an ED(50) value of 3.13 (1.54-6.34) mg/kg, and reduced response rates with an ED(50) value of 20.39 (7.24-57.44) mg/kg. D-84 incompletely generalized to the cocaine stimulus occasioning a maximal 76% cocaine-lever responding, while reducing response rates with lower potency than cocaine (ED(50)=30.94 (12.34-77.60) mg/kg). Pretreatment with D-84 (9.6-30.4 mg/kg) significantly (P<0.05) reduced cocaine intake at 17.1 mg/kg D-84 when cocaine was self-administered at 0.5 mg/kg/infusion, and at 30.4 mg/kg D-84 when cocaine was self-administered at 0.1, 0.5 .and 1.0 mg/kg/infusion. During self-administration tests with D-84 (0.1-1 mg/kg/infusion), numbers of infusions significantly exceeded vehicle levels at 0.3 mg/kg/infusion. These results show that D-84 pretreatment can decrease cocaine intake especially when high doses of cocaine are being self-administered. This observation, combined with its incomplete generalization to the cocaine discriminative stimulus and its reported long duration of action, provides a profile consistent with a potential replacement therapy for treating cocaine-abusing patients. Copyright © 2010 Elsevier B.V. All rights reserved.

12 CFR 22.10 - Notice of servicer's identity.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Notice of servicer's identity. 22.10 Section 22... SPECIAL FLOOD HAZARDS § 22.10 Notice of servicer's identity. (a) Notice requirement. When a bank makes... designee) in writing of the identity of the servicer of the loan. The Director of FEMA has designated the...

9 CFR 3.84 - Cleaning, sanitization, housekeeping, and pest control.

Science.gov (United States)

2010-01-01

..., and pest control. 3.84 Section 3.84 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION..., sanitization, housekeeping, and pest control. (a) Cleaning of primary enclosures. Excreta and food waste must... from becoming soiled, and to reduce disease hazards, insects, pests, and odors. Dirt floors, floors...

42 CFR 84.1130 - Respirators; description.

Science.gov (United States)

2010-10-01

...; Pesticide; Paint Spray; Powered Air-Purifying High Efficiency Respirators and Combination Gas Masks § 84...., dust clouds produced in mining, quarrying, and tunneling, and in dusts produced during industrial... respective vapors, or from the chemical reaction between their respective vapors and gases. (3) Air-purifying...

45 CFR 84.22 - Existing facilities.

Science.gov (United States)

2010-10-01

... HANDICAP IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Accessibility § 84.22 Existing facilities. (a) Accessibility. A recipient shall operate its program or activity so that when each part is..., welfare, or other social services at alternate accessible sites, alteration of existing facilities and...

24 CFR 84.41 - Recipient responsibilities.

Science.gov (United States)

2010-04-01

.... Matters concerning violation of statute are to be referred to such Federal, State or local authority as... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards § 84... authority, without recourse to HUD, regarding the settlement and satisfaction of all contractual and...

75 FR 19633 - Combined Notice of Filings No. 1

Science.gov (United States)

2010-04-15

.... Eastern Time on Tuesday, April 27, 2010. Docket Numbers: ER10-1025-000. Applicants: Just Energy Ohio, LLC.... Accession Number: 20100407-5039. Comment Date: 5 p.m. Eastern Time on Wednesday, April 28, 2010. Docket.... Accession Number: 20100407-5040. Comment Date: 5 p.m. Eastern Time on Wednesday, April 28, 2010. Take notice...

76 FR 24064 - Arizona Public Service Company, Palo Verde Nuclear Generating Station, Units 1, 2, and 3, Notice...

Science.gov (United States)

2011-04-29

... Service Company, Palo Verde Nuclear Generating Station, Units 1, 2, and 3, Notice of Issuance of Renewed... Company (licensee), the operator of the Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (PVNGS... Plants: Supplement 43, Regarding Palo Verde Nuclear Generating Station,'' issued January 2011, discusses...

77 FR 34030 - BOST1 Hydroelectric LLC; Notice of Intent To File License Application, Filing of Pre-Application...

Science.gov (United States)

2012-06-08

... Hydroelectric LLC; Notice of Intent To File License Application, Filing of Pre-Application Document, and.... Date Filed: March 21, 2012. d. Submitted By: BOST1 Hydroelectric LLC (BOST1). e. Name of Project: Coon Rapids Dam Hydroelectric Project. f. Location: Mississippi River in Hennepin and Anoka counties...

STS-84 oxygen generator for Mir on display at SPACEHAB

Science.gov (United States)

1997-01-01

Representatives of RSC Energia in Russia and other onlookers in the SPACEHAB Payload Processing Facility examine an oxygen generator which the Space Shuttle Atlantis will carry to the Russian Mir Space Station on Mission STS-84. Sergei Romanov, second from right in the white shirt, is the spokesperson for generator manufacturer RSC Energia. The nearly 300-pound generator will be strapped down on the inside surface of a SPACEHAB Double Module for the trip to Mir. It will replace one of two Mir units that have been malfunctioning recently. The generator functions by electrolysis, which separates water into its oxygen and hydrogen components. The hydrogen is vented and the oxygen is used for breathing by the Mir crew. The generator is 4.2 feet in length and 1.4 feet in diameter. STS-84, which is planned to include a Mir crew exchange of astronaut C. Michael Foale for Jerry M. Linenger, is targeted for a May 15 liftoff. It will be the sixth Shuttle-Mir docking.

10 CFR 205.84 - DOE evaluation.

Science.gov (United States)

2010-01-01

... determines that there is insufficient information upon which to base a decision and if upon request... ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Interpretation § 205.84 DOE evaluation. (a) Processing... relevant to any request for interpretation provided that the person making the request is afforded an...

Clarification of Stevia rebaudiana (Bert. Bertoni extract by adsorption in modified zeolites Clarificação de extrato de Stevia rebaudiana (Bert. Bertoni por adsorção em zeólitas modificadas

Directory of Open Access Journals (Sweden)

Elida de Paula Moraes

2001-05-01

Full Text Available Selective adsorption on zeolites X and A was studied with Stevia rebaudiana (Bert. Bertoni (Asteraceae extract clarification. Ionic exchanges were made with calcium and barium ions in zeolites NaX and NaA and the effect of contact of aqueous extract of dry Stevia rebaudiana Bertoni leaves with CaX, BaX, CaA and BaA zeolites was evaluated. Stevia extract in contact with the zeolite CaX showed highest clarification and did not present alterations of initial characteristics in concentration, glycosides and flavor. In batch tests at room temperature, the contact of Stevia aqueous extract and CaX zeolite provided 70-80% clarification. Since zeolite may be reused, an approximate clarification of 65-70% is possible in regenerated zeolite.No presente trabalho, foi estudada a adsorção seletiva do extrato de Stevia rebaudiana (Bert. Bertoni (Asteraceae nas zeólitas X e A. Foram feitas trocas com íons de cálcio e bário nas zeólitas NaX e NaA. Foi avaliado o efeito do contato do extrato aquoso de Stevia com as zeólitas CaX, BaX, CaA and BaA. Os resultados mostraram que o extrato que ficou em contato com a zeólita CaX foi o que obteve maior descoloração e não teve as características iniciais alteradas, em termos de concentração, glicosídeos e sabor. Com testes feitos em batelada à temperatura ambiente, o contato entre o extrato aquoso de Stevia e a zeólita CaX, proporcionou uma descoloração entre 70-80%. Os testes mostraram ser possível a regeneração da zeólita, sendo possível a utilização da zeólita por mais de uma vez no processo, sendo alcançada uma descoloração entre 65-70%.

26 CFR 301.6323(b)-1 - Protection for certain interests even though notice filed.

Science.gov (United States)

2010-04-01

.... Subsequent to his purchase, B learns of the existence of the tax lien against A. Even though notice of lien... the basis of the facts and circumstances of each individual case. It is immaterial that the notice of... savings deposit, share, or other account evidenced by a passbook (as defined in subparagraph (2) of this...

78 FR 49748 - Ameren Corporation; Notice of Filing

Science.gov (United States)

2013-08-15

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. AC11-46-000] Ameren Corporation; Notice of Filing Take notice that on July 22, 2013, Ameren Corporation (Ameren) submitted a... Refund Report and Providing Guidance, issued on June 13, 2013.\\1\\ \\1\\ Ameren Corporation, 143 FERC ] 61...

Information on the REAL84 exercise

International Nuclear Information System (INIS)

Zijp, W.L.; Cullen, D.E.

1986-01-01

This document gives information on the interlaboratory exercise REAL84. This exercise has as aim the improvement of the assessment of accuracies in radiation damage predictions by using good quality input data and proper calculation methods. In the exercise integral damage parameters (such as displacements per atom, or produced gas atoms) and spectrum characteristics are calculated for neutron spectra which are adjusted to fit experimental reaction rates obtained with activation spectrometry. The main difference with the preceding exercise REAL80 is that now improved information can be applied in the input data sets of the exercise. The improvement concerns mainly the availability of uncertainty information for the neutron spectrum and cross-section data. All parties interested are encouraged to participate in the exercise and to request from the IAEA the magnetic tape R84, which contains all input information. In order to meet the time schedule (see appendix) fast action is required. (author)

19 CFR 10.84 - Automotive vehicles and articles for use as original equipment in the manufacture of automotive...

Science.gov (United States)

2010-04-01

... original equipment in the manufacture of automotive vehicles. 10.84 Section 10.84 Customs Duties U.S... vehicles and articles for use as original equipment in the manufacture of automotive vehicles. (a)(1... his declaration that the articles are being imported for use as original equipment in the manufacture...

Low-temperature electron microscopy and electron diffraction study of La/sub 1. 84/Sr/sub 0. 16/CuO/sub 4/

Energy Technology Data Exchange (ETDEWEB)

Onozuka, Takashi; Omori, Mamoru; Hirabayashi, Makoto; Syono, Yasuhiko

1987-10-01

A high-T/sub c/ superconducting compound, La/sub 1.84/Sr/sub 0.16/CuO/sub 4/, has been investigated by electron microscopy and electron diffraction in the range from 10 K to ambient temperature. The tetragonal K/sub 2/NiF/sub 4/-type structure undergoes an orthorhombic distortion below about 130 K. In the low-temperature phase, extra diffraction spots and twin lamellae are observed reversibly on cooling and heating in situ. Based on the observed results, a plausible structure model with orthorhombic distortion is proposed

24 CFR 84.13 - Debarment and suspension; Drug-Free Workplace.

Science.gov (United States)

2010-04-01

... Workplace. 84.13 Section 84.13 Housing and Urban Development Office of the Secretary, Department of Housing... Debarment and suspension; Drug-Free Workplace. (a) Recipients and subrecipients shall comply with the... and subrecipients shall comply with the requirements of the Drug-Free Workplace Act of 1988 (42 U.S.C...

33 CFR 117.40 - Advance notice for drawbridge opening.

Science.gov (United States)

2010-07-01

... of the advanced notice for the drawbridge will be added to subpart B of this part. [USCG-2001-10881... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Advance notice for drawbridge... SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS General Requirements § 117.40 Advance notice for...

12 CFR 25.44 - Public notice by banks.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Public notice by banks. 25.44 Section 25.44... Public notice by banks. A bank shall provide in the public lobby of its main office and each of its branches the appropriate public notice set forth in appendix B of this part. Only a branch of a bank having...

Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels.

LENUS (Irish Health Repository)

Alzamora, Rodrigo

2011-01-01

Berberine is a plant alkaloid with multiple pharmacological actions, including antidiarrhoeal activity and has been shown to inhibit Cl(-) secretion in distal colon. The aims of this study were to determine the molecular signaling mechanisms of action of berberine on Cl(-) secretion and the ion transporter targets. Monolayers of T84 human colonic carcinoma cells grown in permeable supports were placed in Ussing chambers and short-circuit current measured in response to secretagogues and berberine. Whole-cell current recordings were performed in T84 cells using the patch-clamp technique. Berberine decreased forskolin-induced short-circuit current in a concentration-dependent manner (IC(50) 80 ± 8 μM). In apically permeabilized monolayers and whole-cell current recordings, berberine inhibited a cAMP-dependent and chromanol 293B-sensitive basolateral membrane K(+) current by 88%, suggesting inhibition of KCNQ1 K(+) channels. Berberine did not affect either apical Cl(-) conductance or basolateral Na(+)-K(+)-ATPase activity. Berberine stimulated p38 MAPK, PKCα and PKA, but had no effect on p42\\/p44 MAPK and PKCδ. However, berberine pre-treatment prevented stimulation of p42\\/p44 MAPK by epidermal growth factor. The inhibitory effect of berberine on Cl(-) secretion was partially blocked by HBDDE (∼65%), an inhibitor of PKCα and to a smaller extent by inhibition of p38 MAPK with SB202190 (∼15%). Berberine treatment induced an increase in association between PKCα and PKA with KCNQ1 and produced phosphorylation of the channel. We conclude that berberine exerts its inhibitory effect on colonic Cl(-) secretion through inhibition of basolateral KCNQ1 channels responsible for K(+) recycling via a PKCα-dependent pathway.

Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels.

LENUS (Irish Health Repository)

Alzamora, Rodrigo

2012-02-01

Berberine is a plant alkaloid with multiple pharmacological actions, including antidiarrhoeal activity and has been shown to inhibit Cl(-) secretion in distal colon. The aims of this study were to determine the molecular signaling mechanisms of action of berberine on Cl(-) secretion and the ion transporter targets. Monolayers of T84 human colonic carcinoma cells grown in permeable supports were placed in Ussing chambers and short-circuit current measured in response to secretagogues and berberine. Whole-cell current recordings were performed in T84 cells using the patch-clamp technique. Berberine decreased forskolin-induced short-circuit current in a concentration-dependent manner (IC(50) 80 +\\/- 8 muM). In apically permeabilized monolayers and whole-cell current recordings, berberine inhibited a cAMP-dependent and chromanol 293B-sensitive basolateral membrane K(+) current by 88%, suggesting inhibition of KCNQ1 K(+) channels. Berberine did not affect either apical Cl(-) conductance or basolateral Na(+)-K(+)-ATPase activity. Berberine stimulated p38 MAPK, PKCalpha and PKA, but had no effect on p42\\/p44 MAPK and PKCdelta. However, berberine pre-treatment prevented stimulation of p42\\/p44 MAPK by epidermal growth factor. The inhibitory effect of berberine on Cl(-) secretion was partially blocked by HBDDE ( approximately 65%), an inhibitor of PKCalpha and to a smaller extent by inhibition of p38 MAPK with SB202190 ( approximately 15%). Berberine treatment induced an increase in association between PKCalpha and PKA with KCNQ1 and produced phosphorylation of the channel. We conclude that berberine exerts its inhibitory effect on colonic Cl(-) secretion through inhibition of basolateral KCNQ1 channels responsible for K(+) recycling via a PKCalpha-dependent pathway.

Lauric Acid Stimulates Mammary Gland Development of Pubertal Mice through Activation of GPR84 and PI3K/Akt Signaling Pathway.

Science.gov (United States)

Meng, Yingying; Zhang, Jing; Zhang, Fenglin; Ai, Wei; Zhu, Xiaotong; Shu, Gang; Wang, Lina; Gao, Ping; Xi, Qianyun; Zhang, Yongliang; Liang, Xingwei; Jiang, Qingyan; Wang, Songbo

2017-01-11

It has been demonstrated that dietary fat affects pubertal mammary gland development. However, the role of lauric acid (LA) in this process remains unclear. Thus, this study aimed to investigate the effects of LA on mammary gland development in pubertal mice and to explore the underlying mechanism. In vitro, 100 μM LA significantly promoted proliferation of mouse mammary epithelial cell line HC11 by regulating expression of proliferative markers (cyclin D1/3, p21, PCNA). Meanwhile, LA activated the G protein-coupled receptor 84 (GPR84) and PI3K/Akt signaling pathway. In agreement, dietary 1% LA enhanced mammary duct development, increased the expression of GPR84 and cyclin D1, and activated PI3K/Akt in mammary gland of pubertal mice. Furthermore, knockdown of GPR84 or inhibition of PI3K/Akt totally abolished the promotion of HC11 proliferation induced by LA. These results showed that LA stimulated mammary gland development of pubertal mice through activation of GPR84 and PI3K/Akt signaling pathway.

75 FR 81264 - Public Utility District No. 1 of Douglas County; Notice of Intent To Prepare an Environmental...

Science.gov (United States)

2010-12-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 2149-152] Public Utility District No. 1 of Douglas County; Notice of Intent To Prepare an Environmental Impact Statement December 16, 2010. On May 27, 2010, Public Utility District No. 1 of Douglas County filed an application for the...

75 FR 51257 - Public Utility District No. 1 of Douglas County (Douglas PUD); Notice of Application Ready for...

Science.gov (United States)

2010-08-19

... District No. 1 of Douglas County (Douglas PUD); Notice of Application Ready for Environmental Analysis and...: May 27, 2010. d. Applicant: Public Utility District No. 1 of Douglas County (Douglas PUD). e. Name of... in Douglas, Okanogan, and Chelan Counties, Washington. The project currently occupies 15.15 acres of...

The Re-evaluation of {sup 84}Rb decay data

Energy Technology Data Exchange (ETDEWEB)

Xiaolong, Huang; Chunmei, Zhou [Chinese Nuclear Data Center, Beijing, BJ (China)

1996-06-01

The {sup 84}Rb is an important radionuclide and its decay data are fundamental data in nuclear applications. The decay data for {sup 84}Rb were re-evaluated. The energies and intensities of {gamma} rays and their internal conversion coefficients, energies and intensities of Auger electrons, conversion electrons and x-rays, were recommended. The decay scheme was also given. The balance of radiation rays intensities and energies was checked. (9 tabs., 2 figs.).

76 FR 51126 - Proposed Collection; Comment Request for Notice; Notice

Science.gov (United States)

2011-08-17

... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Notice; Notice AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... in electing investment partnership (EIP). DATES: Written comments should be received on or before...

Neutron transition multipole moment for /sup 88/Sr(. cap alpha. ,. cap alpha. ')/sup 88/Sr (2/sup +/, 1. 84 MeV)

Energy Technology Data Exchange (ETDEWEB)

Datta, S.K.; Ray, S.; Majumdar, H.; Ghosh, S.K.; Samanta, C.; Dasgupta, P.; Chintalapudi, S.N.; Banerjee, S.R.

1989-04-01

The neutron transition multipole moment, M/sub n/, for (0/sup +/..-->..2/sup +/, 1.84 MeV) transition is inferred by measuring the (..cap alpha..,..cap alpha..') angular distribution at E/sub ..cap alpha../ = 50 MeV and comparing it with a microscopic distorted-wave Born approximation calculation. Proton transition densities are taken from electron scattering data. M/sub n//M/sub p/ is found to be substantially less than N/Z in agreement with the (p,p') result.

Diindolylmethane Derivatives: Potent Agonists of the Immunostimulatory Orphan G Protein-Coupled Receptor GPR84.

Science.gov (United States)

Pillaiyar, Thanigaimalai; Köse, Meryem; Sylvester, Katharina; Weighardt, Heike; Thimm, Dominik; Borges, Gleice; Förster, Irmgard; von Kügelgen, Ivar; Müller, Christa E

2017-05-11

The G i protein-coupled receptor GPR84, which is activated by (hydroxy)fatty acids, is highly expressed on immune cells. Recently, 3,3'-diindolylmethane was identified as a heterocyclic, nonlipid-like GPR84 agonist. We synthesized a broad range of diindolylmethane derivatives by condensation of indoles with formaldehyde in water under microwave irradiation. The products were evaluated at the human GPR84 in cAMP and β-arrestin assays. Structure-activity relationships (SARs) were steep. 3,3'-Diindolylmethanes bearing small lipophilic residues at the 5- and/or 7-position of the indole rings displayed the highest activity in cAMP assays, the most potent agonists being di(5-fluoro-1H-indole-3-yl)methane (38, PSB-15160, EC 50 80.0 nM) and di(5,7-difluoro-1H-indole-3-yl)methane (57, PSB-16671, EC 50 41.3 nM). In β-arrestin assays, SARs were different, indicating biased agonism. The new compounds were selective versus related fatty acid receptors and the arylhydrocarbon receptor. Selected compounds were further investigated and found to display an ago-allosteric mechanism of action and increased stability in comparison to the lead structure.

47 CFR 51.329 - Notice of network changes: Methods for providing notice.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Notice of network changes: Methods for providing notice. 51.329 Section 51.329 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED...) Filing a public notice with the Commission; or (2) Providing public notice through industry fora...

42 CFR 84.194 - Filters used with chemical cartridges; location; replacement.

Science.gov (United States)

2010-10-01

...; replacement. 84.194 Section 84.194 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN...; replacement. (a) Particulate matter filters used in conjunction with a chemical cartridge shall be located on... replacement on the cartridge. ...

24 CFR 84.42 - Codes of conduct.

Science.gov (United States)

2010-04-01

..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards § 84.42 Codes of... substantial or the gift is an unsolicited item of nominal value. The standards of conduct shall provide for...

40 CFR 86.607-84 - Sample selection.

Science.gov (United States)

2010-07-01

... Auditing of New Light-Duty Vehicles, Light-Duty Trucks, and Heavy-Duty Vehicles § 86.607-84 Sample..., once a manufacturer ships any vehicle from the test sample, it relinquishes the prerogative to conduct...

49 CFR 1242.84 - Marketing, sales, and public relations and advertising (accounts XX-63-88, XX-63-89 and XX-63-93).

Science.gov (United States)

2010-10-01

... 49 Transportation 9 2010-10-01 2010-10-01 false Marketing, sales, and public relations and advertising (accounts XX-63-88, XX-63-89 and XX-63-93). 1242.84 Section 1242.84 Transportation Other... PASSENGER SERVICE FOR RAILROADS 1 Operating Expenses § 1242.84 Marketing, sales, and public relations and...

PTH(1-84) Replacement Therapy in Hypoparathyroidism (HypoPT): a Randomized Controlled Trial on Pharmacokinetics and Dynamic effects Following 24 Weeks of treatment

DEFF Research Database (Denmark)

Sikjær, Tanja Tvistholm; Amstrup, Anne Kristine; Rolighed, Lars

In HypoPT, lack of PTH necessitates treatment with calcium and vitamin D analogues in order to avoid hypocalcemia. To study if replacement with the missing hormone possesses advantages, we randomized 62 patients with HypoPT to 24-wks with a daily SC injection in the thigh of PTH(1-84) 100 μg...... or similar placebo, as add to conventional therapy. At end of study, we performed a 24h biochemical monitoring on 39 patients (22 on PTH) in order to assess effects on diurnal variations in calcium-phosphate homeostasis. Following injection, blood samples were obtained at 0.25, 0.5, 1.0, 1.5, 2, 3, 4, 5, 6...

Efficiency of enzymatic and other alternative clarification and fining treatments on turbidity and haze in cherry juice

DEFF Research Database (Denmark)

Meyer, Anne Boye Strunge; Köser, C.; Adler-Nissen, Jens

2001-01-01

function. Individual and interactive effects on turbidity and haze formation in precentrifuged and uncentrifuged cherry juice of treatments with pectinase, acid protease, bromelain, gallic acid, and gelatin-silica sol were investigated in a factorial experimental design with 32 different parameter...... combinations. Gelatin-silica sol consistently had the best effect on juice clarity. Centrifugation of cherry juice (10000g for 15 min) prior to clarification treatment significantly improved juice clarity and diminished the rate of haze formation during cold storage of juice. Both treatment of precentrifuged...... cherry juice with Novozym 89L protease and co- addition of pectinase and gallic acid improved cherry juice clarity and diminished haze levels. None of the alternative treatments produced the unwieldy colloids notorious to gelatin- silica sol treatment. The data suggest that several alternative...

75 FR 39230 - Combined Notice of Filings

Science.gov (United States)

2010-07-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings July 1, 2010. Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report..., July 12, 2010. Docket Numbers: RP10-922-000. Applicants: Venice Gathering System, LLC. Description...

75 FR 53303 - Notice of Public Hearing

Science.gov (United States)

2010-08-31

... FINANCIAL CRISIS INQUIRY COMMISSION Notice of Public Hearing AGENCY: Financial Crisis Inquiry Commission. ACTION: Notice. SUMMARY: The next public hearing of the Financial Crisis Inquiry Commission (FCIC....gov . DATES: The hearing will be held on: Wednesday, September 1, 2010, 9 a.m. EDT; and Thursday...

17 CFR 8.11 - Notice of charges.

Science.gov (United States)

2010-04-01

... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Notice of charges. 8.11 Section 8.11 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION EXCHANGE PROCEDURES FOR DISCIPLINARY, SUMMARY, AND MEMBERSHIP DENIAL ACTIONS Disciplinary Procedure § 8.11 Notice of...

Far infrared near normal specular reflectivity of Nix(SiO2)1-x (x = 1.0, 0.84, 0.75, 0.61, 0.54, 0.28) granular films

KAUST Repository

Massa, Néstor E.

2010-04-01

One of the current issues at the basis of the understanding of novel materials is the degree of the role played by spatial inhomogeneities due to subtle phase separations. To clarify this picture here we compare the plain glass network response of transition metal granular films with different metal fractions against what is known for conducting oxides. Films for Nix(SiO2)1-x (x = 1.0, 0.84, 0.75, 0.61, 0.54, 0.28) were studied by temperature dependent far infrared measurements. While for pure Ni the spectrum shows a flat high reflectivity, those for x ∼ 0.84 and ∼0.75 have a Drude component, vibrational modes mostly carrier screened, and a long tail that extents toward near infrared. This is associated with hopping electron conductivity and strong electron-phonon interactions. The relative reduction of the number of carriers in Ni0.75(SiO2)0.25 allows less screened phonon bands on the top of a continuum and a wide and overdamped oscillator at mid-infrared frequencies. Ni0.54(SiO2)0.46 and Ni0.28(SiO2)0.72 have well defined vibrational bands and a sharp threshold at ∼1450 cm-1. It is most remarkable that a distinctive resonant peak at ∼1250 cm-1 found for p-polarized angle dependent specular reflectivity. It originates in an electron cloud traced to electrons that are not able to overcome the metal-dielectric interface that, beating against the positive background, generates the electric dipole. Overall, we conclude that the spectra are analogous to those regularly found in conducting oxides where with a suitable percolating network polarons are formed. © 2009 Elsevier B.V. All rights reserved.

Tannase Production by Penicillium Atramentosum KM under SSF and its Applications in Wine Clarification and Tea Cream Solubilization.

Science.gov (United States)

Selwal, Manjit K; Yadav, Anita; Selwal, Krishan K; Aggarwal, N K; Gupta, Ranjan; Gautam, S K

2011-01-01

Tannin acyl hydrolase commonly known as tannase is an industrially important enzyme having a wide range of applications, so there is always a scope for novel tannase with better characteristics. A newly isolated tannase-yielding fungal strain identified as Penicillium atramentosum KM was used for tannase production under solid-state fermentation (SSF) using different agro residues like amla (Phyllanthus emblica), ber (Zyzyphus mauritiana), jamun (Syzygium cumini), Jamoa (Eugenia cuspidate) and keekar (Acacia nilotica) leaves. Among these substrates, maximal extracellular tannase production i.e. 170.75 U/gds and 165.56 U/gds was obtained with jamun and keekar leaves respectively at 28ºC after 96 h. A substrate to distilled water ratio of 1:2 (w/v) was found to be the best for tannase production. Supplementation of sodium nitrate (NaNO3) as nitrogen source had enhanced tannase production both in jamun and keekar leaves. Applications of the enzyme were studied in wine clarification and tea cream solubilization. It resulted in 38.05% reduction of tannic acid content in case of jamun wine, 43.59% reduction in case of grape wine and 74% reduction in the tea extract after 3 h at 35°C.

Collectivity of high spin states in {sup 84}Zr

Energy Technology Data Exchange (ETDEWEB)

Lister, C.J.; Blumenthal, D.; Crowell, B. [and others

1995-08-01

{sup 84}Zr is one of the most extensively studied of the A {approximately} 80 rotors, both from theoretical and experimental approaches. It was predicted to be a good candidate to support superdeformation, and to show interesting spectroscopic properties including saturation of its shell-model space at lower spin. We performed an experiment using Gammasphere in its early implementation phase. The reaction of {sup 29}Si on {sup 58}Ni was used to strongly populate {sup 84}Zr at high spin. Thin and thick targets were used to allow the extraction of transitional matrix elements at very high spin, and to allow a sensitive search for superdeformed states. Data analysis is in progress. The large data set allowed us to extend the previously known bands considerably. Candidates for a staggered M1-band, found previously {sup 86}Zr, were located. To date, no evidence for superdeformed bands was found. Analysis was slowed by the relocation of all the participants in this experiment, but we hope to complete the lifetime analysis this year. This analysis has become especially topical, due to reported measurements of superdeformation in this region.

US Army Medical Bioengineering Research and Development Laboratory Annual Progress Report for FY 84. Volume 1

Science.gov (United States)

1984-10-01

guanidIne nitrate, is biodegraded slowly in surface waters alone and relatively rapidly if present with metabolizable carbon, in which case the compound...Operation." AORN Journal 40 (1984):330. Goethals, Gerald B. "So, You Want to be in Movies ?" Today’s OR Nurse 6 (1984):36-37. Goyal, Sagar M., S.A. Schaub...Development Laboratory MR 8-84 (May 1984). Mitchell, Wayne R. Preliminarx Results of Biodegradation Studies for Guanidine Nitrate. US Army Medical

New design centrifugal contactor remotely controlled for solvent extraction operations for feed clarification

International Nuclear Information System (INIS)

Candelieri, T.; Gerardi, A.; Petrigliano, G.; Siepe, V.

1987-01-01

The project concept of the nuclear facilities has gone through an important evolution in the past years in relation to the need of: garantiing the remote maintenance reducing workers exposure when operating in high-risk areas; making easier final decommissioning operations of the plants. In this way the ITREC pilot plant (built in 1970s') for its modular characteristic based on Rack Removal System (R.R.S.) was the first example of this new concept of project. A further development, in the field of remote maintenance and decommissioning operations, we can obtain associating to the R.R.S. concept that of projecting the single components (only for the critical ones) remotely demountable in their higher radioactive parts to consent the maintenance-substitution and/or decommissioning operations without interfering with remaining parts of the plant which it is connected. All of this helps in the realization of the aim making better plant operations reducing drastically work time and therefore non-functioning period of the plants. These principles have been applicated in the realization of two important components in reprocessing plant: the centrifugal contactor for solvent extraction and feed clarification centrifuge

76 FR 388 - Southern Nuclear Operating Company; Vogtle Electric Generating Plant, Unit Nos. 1 and 2; Notice...

Science.gov (United States)

2011-01-04

... Operating Company; Vogtle Electric Generating Plant, Unit Nos. 1 and 2; Notice of Consideration of Issuance... Web site http://www.regulations.gov . Because your comments will not be edited to remove any... will not edit their comments to remove any identifying or contact information, and therefore, they...

12 CFR Appendix B to Part 25 - CRA Notice

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false CRA Notice B Appendix B to Part 25 Banks and... DEPOSIT PRODUCTION REGULATIONS Pt. 25, App. B Appendix B to Part 25—CRA Notice (a) Notice for main offices... the Federal Community Reinvestment Act (CRA), the Comptroller of the Currency evaluates our record of...

21 CFR 1.283 - What happens to food that is imported or offered for import without adequate prior notice?

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false What happens to food that is imported or offered for import without adequate prior notice? 1.283 Section 1.283 Food and Drugs FOOD AND DRUG... Imported Food Consequences § 1.283 What happens to food that is imported or offered for import without...

GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer's disease.

Science.gov (United States)

Audoy-Rémus, Julie; Bozoyan, Lusine; Dumas, Aline; Filali, Mohammed; Lecours, Cynthia; Lacroix, Steve; Rivest, Serge; Tremblay, Marie-Eve; Vallières, Luc

2015-05-01

Microglia surrounds the amyloid plaques that form in the brains of patients with Alzheimer's disease (AD), but their role is controversial. Under inflammatory conditions, these cells can express GPR84, an orphan receptor whose pathophysiological role is unknown. Here, we report that GPR84 is upregulated in microglia of APP/PS1 transgenic mice, a model of AD. Without GPR84, these mice display both accelerated cognitive decline and a reduced number of microglia, especially in areas surrounding plaques. The lack of GPR84 affects neither plaque formation nor hippocampal neurogenesis, but promotes dendritic degeneration. Furthermore, GPR84 does not influence the clinical progression of other diseases in which its expression has been reported, i.e., experimental autoimmune encephalomyelitis (EAE) and endotoxic shock. We conclude that GPR84 plays a beneficial role in amyloid pathology by acting as a sensor for a yet unknown ligand that promotes microglia recruitment, a response affecting dendritic degeneration and required to prevent further cognitive decline. Copyright © 2015 Elsevier Inc. All rights reserved.

Production, Characterization of Tannase from Penicillium montanense URM 6286 under SSF Using Agroindustrial Wastes, and Application in the Clarification of Grape Juice (Vitis vinifera L.)

Science.gov (United States)

Cruz, Roberta; Fonseca, Julyanna Cordoville; de Medeiros, Erika Valente; Maciel, Marília de Holanda Cavalcanti; Moreira, Keila Aparecida; Motta, Cristina Maria de Souza

2014-01-01

Tannase is an enzyme that hydrolyzes esters and lateral bonds of tannins, such as tannic acid, releasing glucose and gallic acid and stands out in the clarification of wines and juices. Fungi of the genera Aspergillus and Penicillium are excellent producers of this enzyme. The search for fungi that produce high levels of tannase as well as new substrates for the enzyme production by the SSF is required. The objectives of this study were to evaluate the production of tannase by Aspergillus and Penicillium species through SSF using leaves and agroindustrial waste barbados cherry and mangaba fruit as substrate, select the best producer, optimize production, characterize the crude enzyme extract, and apply it the clarification of grape juice. Selecting the best producer was performed by planning Placket-Burman and RSM. P. montanense showed highest activity with 41.64 U/mL after 72 h of fermentation residue using barbados cherry, with 3.5% tannic acid and 70% moisture. The enzyme showed the highest activity at pH 9.0 and 50°C. The tannase of P. montanense was stable over a wide pH range and temperature and, when applied to grape juice, showed higher efficiency by reducing 46% of the tannin content after incubation 120 m. PMID:25506607

Production, Characterization of Tannase from Penicillium montanense URM 6286 under SSF Using Agroindustrial Wastes, and Application in the Clarification of Grape Juice (Vitis vinifera L.

Directory of Open Access Journals (Sweden)

Juliana Silva de Lima

2014-01-01

Full Text Available Tannase is an enzyme that hydrolyzes esters and lateral bonds of tannins, such as tannic acid, releasing glucose and gallic acid and stands out in the clarification of wines and juices. Fungi of the genera Aspergillus and Penicillium are excellent producers of this enzyme. The search for fungi that produce high levels of tannase as well as new substrates for the enzyme production by the SSF is required. The objectives of this study were to evaluate the production of tannase by Aspergillus and Penicillium species through SSF using leaves and agroindustrial waste barbados cherry and mangaba fruit as substrate, select the best producer, optimize production, characterize the crude enzyme extract, and apply it the clarification of grape juice. Selecting the best producer was performed by planning Placket-Burman and RSM. P. montanense showed highest activity with 41.64 U/mL after 72 h of fermentation residue using barbados cherry, with 3.5% tannic acid and 70% moisture. The enzyme showed the highest activity at pH 9.0 and 50°C. The tannase of P. montanense was stable over a wide pH range and temperature and, when applied to grape juice, showed higher efficiency by reducing 46% of the tannin content after incubation 120 m.

Production, characterization of tannase from Penicillium montanense URM 6286 under SSF using agroindustrial wastes, and application in the clarification of grape juice (Vitis vinifera L.).

Science.gov (United States)

de Lima, Juliana Silva; Cruz, Roberta; Fonseca, Julyanna Cordoville; de Medeiros, Erika Valente; Maciel, Marília de Holanda Cavalcanti; Moreira, Keila Aparecida; Motta, Cristina Maria de Souza

2014-01-01

Tannase is an enzyme that hydrolyzes esters and lateral bonds of tannins, such as tannic acid, releasing glucose and gallic acid and stands out in the clarification of wines and juices. Fungi of the genera Aspergillus and Penicillium are excellent producers of this enzyme. The search for fungi that produce high levels of tannase as well as new substrates for the enzyme production by the SSF is required. The objectives of this study were to evaluate the production of tannase by Aspergillus and Penicillium species through SSF using leaves and agroindustrial waste barbados cherry and mangaba fruit as substrate, select the best producer, optimize production, characterize the crude enzyme extract, and apply it the clarification of grape juice. Selecting the best producer was performed by planning Placket-Burman and RSM. P. montanense showed highest activity with 41.64 U/mL after 72 h of fermentation residue using barbados cherry, with 3.5% tannic acid and 70% moisture. The enzyme showed the highest activity at pH 9.0 and 50°C. The tannase of P. montanense was stable over a wide pH range and temperature and, when applied to grape juice, showed higher efficiency by reducing 46% of the tannin content after incubation 120 m.

42 CFR 84.161 - Man test for gases and vapors; Type B and Type BE respirators; test requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Man test for gases and vapors; Type B and Type BE respirators; test requirements. 84.161 Section 84.161 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Supplied-Air...

42 CFR 84.160 - Man test for gases and vapors; Type A and Type AE respirators; test requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Man test for gases and vapors; Type A and Type AE respirators; test requirements. 84.160 Section 84.160 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Supplied-Air...

17 CFR 248.5 - Annual privacy notice to customers required.

Science.gov (United States)

2010-04-01

... customers required. 248.5 Section 248.5 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... Safeguarding Personal Information Privacy and Opt Out Notices § 248.5 Annual privacy notice to customers required. (a)(1) General rule. You must provide a clear and conspicuous notice to customers that accurately...

Clarification of Employer’s Continuing Obligation To Make and Maintain an Accurate Record of Each Recordable Injury and Illness. Final rule.

Science.gov (United States)

2017-05-03

Under the Congressional Review Act, Congress has passed, and the President has signed, Public Law 115-21, a resolution of disapproval of OSHA's final rule titled, "Clarification of Employer's Continuing Obligation to Make and Maintain an Accurate Record of each Recordable Injury and Illness." OSHA published the rule, which contained various amendments to OSHA's recordkeeping regulations, on December 19, 2016. The amendments became effective on January 18, 2017. Because Public Law 115-21 invalidates the amendments to OSHA's recordkeeping regulations contained in the rule promulgated on December 19, 2016, OSHA is hereby removing those amendments from the Code of Federal Regulations.

7 CFR 8.4 - Basic premises.

Science.gov (United States)

2010-01-01

... the Secretary of Agriculture 4-H CLUB NAME AND EMBLEM § 8.4 Basic premises. (a) The 4-H Club Name and Emblem are held in trust by the Secretary of Agriculture of the United States Department of Agriculture.... (b) The 4-H Club Name and Emblem may be used by authorized representatives of the United States...

78 FR 39254 - Foreign-Trade Zone 84-Houston, Texas; Application for Expansion

Science.gov (United States)

2013-07-01

...). FTZ 84 currently consists of 25 sites (2,756.74 acres total) at port facilities, industrial parks and... stated--are as follows: Site 1 (420.70 acres)--Houston Ship Channel Turning Basin, Clinton Drive at Highway 610 East Loop; Site 2 (97 acres)--Houston Ship Channel (Bulk Materials Handling Plant), north bank...

17 CFR 160.9 - Delivering privacy and opt out notices.

Science.gov (United States)

2010-04-01

... the web site; or (2) The customer has requested that you refrain from sending any information regarding the customer relationship, and your current privacy notice remains available to the customer upon... that a consumer will receive actual notice of your annual privacy notice if: (1) The customer uses your...

12 CFR 573.9 - Delivering privacy and opt out notices.

Science.gov (United States)

2010-01-01

... the web site; or (2) The customer has requested that you refrain from sending any information regarding the customer relationship, and your current privacy notice remains available to the customer upon... that a customer will receive actual notice of your annual privacy notice if: (1) The customer uses your...

77 FR 9232 - Lock+ Hydro Friends Fund XXXVIII; FFP Project 1, LLC; Notice Announcing Preliminary Permit Drawing

Science.gov (United States)

2012-02-16

...+ Hydro Friends Fund XXXVIII; FFP Project 1, LLC; Notice Announcing Preliminary Permit Drawing The..., or her designee, will conduct a random drawing to determine the filing priority of the applicants... section 4.37 of its regulations.\\2\\ The priority established by this drawing will be used to determine...

76 FR 45312 - Notice of Intent To Prepare an Environmental Assessment, Notice of Public Meetings, and Notice To...

Science.gov (United States)

2011-07-28

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Notice of Intent To Prepare an Environmental Assessment, Notice of Public Meetings, and Notice To Request Public Scoping Comments for the Air Tour Management Plan Program at Golden Gate National Recreation Area, San Francisco Maritime National Historical Park and Point Reyes National...

42 CFR 84.75 - Half-mask facepieces, full facepieces, mouthpieces; fit; minimum requirements.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Half-mask facepieces, full facepieces, mouthpieces... RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing Apparatus § 84.75 Half-mask facepieces, full facepieces, mouthpieces; fit; minimum requirements. (a) Half-mask facepieces and full facepieces shall be...

75 FR 27338 - San Diego Gas & Electric Company; Notice of Filing

Science.gov (United States)

2010-05-14

..., Order on Rehearing and Motions for Clarification and Accounting, 125 FERC ] 61,214. Any person desiring... protests and interventions in lieu of paper using the ``eFiling'' link at http://www.ferc.gov . Persons...

10 CFR 10.22 - Notice to individual.

Science.gov (United States)

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Notice to individual. 10.22 Section 10.22 Energy NUCLEAR... NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.22 Notice to individual. A... Counsel, and signed by the Director, Office of Administration, must be presented to each individual whose...

12 CFR 40.9 - Delivering privacy and opt out notices.

Science.gov (United States)

2010-01-01

... conspicuous manner on the web site; or (2) The customer has requested that the bank refrain from sending any information regarding the customer relationship, and the bank's current privacy notice remains available to... that a customer will receive actual notice of the bank's annual privacy notice if: (1) The customer...

76 FR 30206 - Southern Nuclear Operating Company, Inc., Vogtle Electric Generating Plant, Unit 1 and 2; Notice...

Science.gov (United States)

2011-05-24

... Operating Company, Inc., Vogtle Electric Generating Plant, Unit 1 and 2; Notice of Consideration of Issuance..., http://www.regulations.gov . Because your comments will not be edited to remove any identifying or... received from other persons for submission to the NRC inform those persons that the NRC will not edit their...

75 FR 10546 - Shipping Coordinating Committee; Notice of Committee Meeting

Science.gov (United States)

2010-03-08

... prevent explosions on oil and chemical tankers transporting low flash point cargoes --Clarification of... on evacuation analysis for new and existing passenger ships --Consideration of IACS unified interpretations --Fixed hydrocarbon gas detection systems on double-hull tankers --Harmonization of the...

TRIAM-1 turbulent heating experiment

Energy Technology Data Exchange (ETDEWEB)

Nakamura, Yukio; Hiraki, Naoji; Nakamura, Kazuo; Kikuchi, Mitsuru; Nagao, Akihiro [Kyushu Univ., Fukuoka (Japan). Research Inst. for Applied Mechanics

1983-02-01

The experimental studies on the containment of high temperature plasma and turbulent heating using the tokamak device with strong magnetic field (TRIAM-1) started in 1977 have achieved much results up to fiscal 1979, and the anticipated objectives were almost attained. The results of these studies were summarized in the ''Report of the results of strong magnetic field tokamak TRIAM-1 experiment''. In this report, the results obtained by the second stage project of the TRIAM-1 project are summarized. The second stage was the two-year project for fiscal 1980 and 81. In the second stage project, by the complete preparation of measuring instrument and the improvement of the experimental setup, the carefully planned experiment on turbulent heating was performed, in particular, the clarification of the mechanism of turbulent heating was the central theme. As the important results obtained, the detection of ion sound waves at the time of turbulent heating, the formation of high energy ions by wave-particle interaction and the clarification of the process of their energy relaxation, and the verification of the effectiveness of double pulse turbulent heating are enumerated.

TRIAM-1 turbulent heating experiment

International Nuclear Information System (INIS)

Nakamura, Yukio; Hiraki, Naoji; Nakamura, Kazuo; Kikuchi, Mitsuru; Nagao, Akihiro

1983-01-01

The experimental studies on the containment of high temperature plasma and turbulent heating using the tokamak device with strong magnetic field (TRIAM-1) started in 1977 have achieved much results up to fiscal 1979, and the anticipated objectives were almost attained. The results of these studies were summarized in the ''Report of the results of strong magnetic field tokamak TRIAM-1 experiment''. In this report, the results obtained by the second stage project of the TRIAM-1 project are summarized. The second stage was the two-year project for fiscal 1980 and 81. In the second stage project, by the complete preparation of measuring instrument and the improvement of the experimental setup, the carefully planned experiment on turbulent heating was performed, in particular, the clarification of the mechanism of turbulent heating was the central theme. As the important results obtained, the detection of ion sound waves at the time of turbulent heating, the formation of high energy ions by waveparticle interaction and the clarification of the process of their energy relaxation, and the verification of the effectiveness of double pulse turbulent heating are enumerated. (Kako, I.)

5 CFR 630.1206 - Notice of leave.

Science.gov (United States)

2010-01-01

... medical treatment, the employee shall provide notice to the agency of his or her intention to take leave... placement or planned medical treatment requires leave to begin within 30 calendar days, the employee shall... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Notice of leave. 630.1206 Section 630...

42 CFR 476.84 - Changes as a result of DRG validation.

Science.gov (United States)

2010-10-01

... 42 Public Health 4 2010-10-01 2010-10-01 false Changes as a result of DRG validation. 476.84... § 476.84 Changes as a result of DRG validation. A provider or practitioner may obtain a review by a QIO... in DRG assignment as a result of QIO validation activities. ...

17 CFR 248.123 - Contents of opt out notice; consolidated and equivalent notices.

Science.gov (United States)

2010-04-01

... EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.123 Contents of opt out notice; consolidated and equivalent notices. (a) Contents of opt out...) The name of the affiliate(s) providing the notice. If the notice is provided jointly by multiple...

Screening and Characterization of Polygalacturonase as Potential Enzyme for Keprok Garut Orange (Citrus nobilis var. chrysocarpa) Juice Clarification

Science.gov (United States)

Widowati, E.; Utami, R.; Kalistyatika, K.

2017-11-01

Use of thermostable enzyme from bacilli for industrial application is significant. This research aimed to isolate thermophilic pectinolytic bacteria from orange peel and vegetable waste which produced thermostable polygalacturonase, to investigate the polygalacturonase ability in clarifying keprok Garut orange juice, and to characterize polygalacturonase based on pH optimum, temperature optimum, enzyme stability, enzyme kinetics KM, and Vmax. Obtained, 14 isolates that further selected to 4 best isolates based on highest polygalacturonase activity and keprok Garut orange juice clarification ability. Four selected enzyme isolates were AR 2, AR 4, KK 4, and KK 5 had ability to increase juice transmittance, decrease juice viscosity and also reduce total soluble solid. Furthermore 4 selected isolates were partially purified by ammonium sulphate precipitation and dialysis method. Four partially purified enzymes were known that enzyme character of AR 2 optimum at pH 6; AR 4 optimum at pH 5.5; KK 4 optimum at pH 6; and KK 5 optimum at pH 4.5. Four enzymes were optimum at temperature 60°C thus stable at temperature 50-60°C, this characteristic indicate that enzymes were thermostable. AR 2 showed active activity stable at pH 4-7; AR 4 showed active activity stable at pH 6-7; KK 4 showed active activity stable at pH 4-6; however KK 5 stable at pH 4-5. Enzyme AR 2 and KK 4 was getting inactive at pH 11, thus AR 4 and KK 5 inactive at pH 12. KM value of AR 2, AR 4, KK 4, and KK 5 was 0.0959; 0.0974; 0.0966; and 0.178 mg/ml respectively. Vmax of AR 2, AR 4, KK 4, and KK 5 was 0.0203; 0.0202; 0.0185; and 0.0229 U/ml respectively. Enzyme AR 2 was the most compatible enzyme to be applied in keprok Garut orange juice clarification for it had the lowest KM value.

42 CFR 84.163 - Man test for gases and vapors; Type C supplied-air respirators, demand and pressure-demand...

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Man test for gases and vapors; Type C supplied-air respirators, demand and pressure-demand classes; test requirements. 84.163 Section 84.163 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

6 CFR 13.12 - Notice of hearing.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Notice of hearing. 13.12 Section 13.12 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.12 Notice of hearing. (a) When the ALJ receives the Complaint and answer, the ALJ will promptly serve a...

29 CFR 1956.84 - Location of plan for inspection and copying.

Science.gov (United States)

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Location of plan for inspection and copying. 1956.84... PLANS Illinois § 1956.84 Location of plan for inspection and copying. A copy of the plan may be inspected and copied during normal business hours at the following locations: Office of State Programs, U.S...

75 FR 8266 - Final Clarification for Chemical Identification Describing Activated Phosphors for TSCA Inventory...

Science.gov (United States)

2010-02-24

... mixture of metal oxides, carbonates, phosphates or acid phosphates, chlorides, and/or fluorides, most... normally included with a new chemical notice submission, such as toxicity data on the chemical substance...

Friction Stir Welding of GR-Cop 84 for Combustion Chamber Liners

Science.gov (United States)

Russell, Carolyn K.; Carter, Robert; Ellis, David L.; Goudy, Richard

2004-01-01

GRCop-84 is a copper-chromium-niobium alloy developed by the Glenn Research Center for liquid rocket engine combustion chamber liners. GRCop-84 exhibits superior properties over conventional copper-base alloys in a liquid hydrogen-oxygen operating environment. The Next Generation Launch Technology program has funded a program to demonstrate scale-up production capabilities of GR-Cop 84 to levels suitable for main combustion chamber production for the prototype rocket engine. This paper describes a novel method of manufacturing the main combustion chamber liner. The process consists of several steps: extrude the GR-Cop 84 powder into billets, roll the billets into plates, bump form the plates into cylinder halves and friction stir weld the halves into a cylinder. The cylinder is then metal spun formed to near net liner dimensions followed by finish machining to the final configuration. This paper describes the friction stir weld process development including tooling and non-destructive inspection techniques, culminating in the successful production of a liner preform completed through spin forming.

77 FR 67862 - Air Traffic Procedures Advisory Committee

Science.gov (United States)

2012-11-14

...The FAA is issuing this notice to advise the public that the FAA's Air Traffic Procedures Advisory Committee (ATPAC) two year charter has been coordinated and signed by the FAA Administrator. The ATPAC charter is valid for two years and provides a venue to review air traffic control procedures and practices for standardization, revision, clarification, and upgrading of terminology and procedures.

77 FR 27835 - Air Traffic Procedures Advisory Committee

Science.gov (United States)

2012-05-11

...The FAA is issuing this notice to advise the public that a meeting of the Federal Aviation Administration Air Traffic Procedures Advisory Committee (ATPAC) will be held to review present air traffic control procedures and practices for standardization, revision, clarification, and upgrading of terminology and procedures. Class B airspace will be a major topic of discussion on the ATPAC Agenda.