Sample records for nostrums

  1. [Traditional nostrum]. (United States)

    Sugiyama, Shigeru


    The commercialization of drugs started toward the end of Heian period (794-1192) when not only aristocrats and monks who were traditional patrons to drug makers, but also local clans and landlords who became powerful as a result of the disbanding of aristocratic manors accumulated enough wealth to spend money on medicine. Although traveling around the country was still a dangerous endeavor, merchants assembled groups to bring lucrative foreign drugs (mainly Chinese) to remote areas. The spread of commercial drugs to common people, however, did not happen until the early Edo period (1603-1867), when the so-called barrier system was installed nationwide to make domestic travel safe. Commercialization started in large cities and gradually spread to other areas. Many nostrums popular until recently appeared in the Genroku period (1688-1703) or later. Many such nostrums were all-cures, often consisting of such active ingredients as Saussureae radix, Agalloch, or Gambir. Even in the Edo period, many people living in agricultural or fishing villages, as well as those in the lower tier, were still poor. Much of the medication available to those people was therefore made of various plant or animal-derived substances that were traditionally used as folk medicines.

  2. The big bang cosmology - enigmas and nostrums

    International Nuclear Information System (INIS)

    Dicke, R.H.; Peebles, P.J.E.


    Some outstanding problems in connection with the big bang cosmology and relativity theory are reviewed under the headings: enigmas; nostrums and elixirs (the universe as Phoenix (an oscillating universe), the anthropomorphic universe (existence of observers in the present universe), reproducing universes (could a mini big bang bounce, perhaps adding entropy and matter and eventually developing into a suitable home for observers), variable strength of the gravitational interaction and oscillating universes (possible bounce models that have led eventually to the present hospitable environment). (U.K.)

  3. Fractal analysis of the dark matter and gas distributions in the Mare-Nostrum universe

    International Nuclear Information System (INIS)

    Gaite, José


    We develop a method of multifractal analysis of N-body cosmological simulations that improves on the customary counts-in-cells method by taking special care of the effects of discreteness and large scale homogeneity. The analysis of the Mare-Nostrum simulation with our method provides strong evidence of self-similar multifractal distributions of dark matter and gas, with a halo mass function that is of Press-Schechter type but has a power-law exponent -2, as corresponds to a multifractal. Furthermore, our analysis shows that the dark matter and gas distributions are indistinguishable as multifractals. To determine if there is any gas biasing, we calculate the cross-correlation coefficient, with negative but inconclusive results. Hence, we develop an effective Bayesian analysis connected with information theory, which clearly demonstrates that the gas is biased in a long range of scales, up to the scale of homogeneity. However, entropic measures related to the Bayesian analysis show that this gas bias is small (in a precise sense) and is such that the fractal singularities of both distributions coincide and are identical. We conclude that this common multifractal cosmic web structure is determined by the dynamics and is independent of the initial conditions

  4. El Mare Nostrum digital: Mito, ideología y realidad de un imaginario sociotécnico

    Directory of Open Access Journals (Sweden)

    Francisco García García


    Full Text Available En el imaginario social de la Red ha aparecido con fuerza el dibujo de una nueva generación formada por jóvenes nacidos en un entorno esencialmente digital. Bajo términos contrastantes como el de ""nativos digitales"" se engloba a un vasto grupo poblacional relacionado estrechamente con las TIC y que ha hecho de las redes un espacio social y personal básico de su actividad, de su forma de habitar y relacionase con el mundo. Pero, ¿cuáles son realmente las características que los definen?, ¿son un grupo realmente homogéneo?, ¿disponen de competencias, habilidades y conductas similares?, ¿cuál es la frontera real que separa a los nativos y a los inmigrantes digitales? ¿Son estos términos apropiados para definir esta nueva realidad social? ¿Responde la realidad social de Internet a este concepto bipolar?Tomando como referencia los principales estudios realizados hasta la fecha, el artículo realiza un ejercicio metafórico dirigido a repensar los rasgos de este universo (nuestro Mare Nostrum Digital con la finalidad de acotar, interpretar y arrojar luz sobre este relevante fenómeno de nuestra actualidad.

  5. Contemporary statecraft for sustained and 'sustainable' growth

    African Journals Online (AJOL)

    Put plainly, the current dominant nostrums and prescriptions informing 'sound' statecraft – 'good governance', 'failing and fragile states', the 'big' or 'new' ...... empirical investigation. American. Economic Review, 91(5), pp. 1369-1401. AMSDEN, A.H. 1997. Bringing production back in: Understanding government's economic ...

  6. How to Get the Teachers We Want (United States)

    Hess, Frederick M.


    "Human capital" is quickly becoming the new site-based management. While few are sure what it means, everyone craves it, has a model to deliver it, and is quick to tout its restorative powers. It's trendy and impressive sounding, but too often settles for recycling familiar nostrums or half-baked ideas in the guise of new jargon. To…

  7. Valores de toxicidad de Co para un cultivo acumulador en suelos agrícolas mediterráneos representativos


    Sacristán Moraga, Daniel; Recatalá Boix, Luis


    4 páginas, 1 tabla. Comunicación presentada al V Simposio Nacional sobre Control de la Degradación y Uso Sostenible de Suelo. 27-30 Junio 2011. Campus Mare Nostrum. Murcia. - Área temática 2: Causas y procesos de la degradación del suelo.

  8. Current and Future Development of a Non-hydrostatic Unified Atmospheric Model (NUMA) (United States)


    following capabilities: 1.  Highly scalable on current and future computer architectures ( exascale computing and beyond and GPUs) 2.  Flexibility... Exascale Computing •  10 of Top 500 are already in the Petascale range •  Should also keep our eyes on GPUs (e.g., Mare Nostrum) 2.  Numerical

  9. Why Band-Aids Don't Work: Analyzing and Evaluating No Child Left Behind (NCLB) in Light of Constructivist Philosophy, Theory, and Practice (United States)

    Shapiro, Arthur; Thompson, Alana S.


    In this paper the No Child Left Behind (NCLB) Act, a top-down, one-size-fits-all coercive nostrum constructed by politicians purportedly to improve all American public schools that piddles with symptoms rather than deal with root causes, is first delineated and analyzed. Its departure from local educational governance to an accountability-focused…

  10. The geopolitical fabric of the border regime in the EU-African borderlands

    NARCIS (Netherlands)

    van Houtum, H.; Mamadouh, V.; Mamadouh, V.; de Jong, S.M.; Thissen, F.; van der Schee, J.; van Meeteren, M.


    The Mediterranean Sea has long been a Mare Nostrum but since the decolonisation in the twentieth century it has become a sharp divide between Europe and Africa. In the past decade, the closure of that border has become symbolized by the desperate attempts of migrants from the global South, mainly

  11. Dust modelling and forecasting in the Barcelona Supercomputing Center: Activities and developments

    Energy Technology Data Exchange (ETDEWEB)

    Perez, C; Baldasano, J M; Jimenez-Guerrero, P; Jorba, O; Haustein, K; Basart, S [Earth Sciences Department. Barcelona Supercomputing Center. Barcelona (Spain); Cuevas, E [Izanaa Atmospheric Research Center. Agencia Estatal de Meteorologia, Tenerife (Spain); Nickovic, S [Atmospheric Research and Environment Branch, World Meteorological Organization, Geneva (Switzerland)], E-mail:


    The Barcelona Supercomputing Center (BSC) is the National Supercomputer Facility in Spain, hosting MareNostrum, one of the most powerful Supercomputers in Europe. The Earth Sciences Department of BSC operates daily regional dust and air quality forecasts and conducts intensive modelling research for short-term operational prediction. This contribution summarizes the latest developments and current activities in the field of sand and dust storm modelling and forecasting.

  12. Dust modelling and forecasting in the Barcelona Supercomputing Center: Activities and developments

    International Nuclear Information System (INIS)

    Perez, C; Baldasano, J M; Jimenez-Guerrero, P; Jorba, O; Haustein, K; Basart, S; Cuevas, E; Nickovic, S


    The Barcelona Supercomputing Center (BSC) is the National Supercomputer Facility in Spain, hosting MareNostrum, one of the most powerful Supercomputers in Europe. The Earth Sciences Department of BSC operates daily regional dust and air quality forecasts and conducts intensive modelling research for short-term operational prediction. This contribution summarizes the latest developments and current activities in the field of sand and dust storm modelling and forecasting.

  13. Health Equity in a Trump Administration. (United States)

    Stone, Deborah


    Donald Trump's rhetoric and leadership are destroying the "culture of community" necessary for progress on health equity. His one-line promises to provide "quality health care at a fraction of the cost" smack of neoliberal nostrums that shifted ever more costs onto patients, thereby preventing many people from getting care. The dangers of Trump go far beyond health policy, however; Trump's presidency threatens the political and cultural institutions that make any good policy possible. Copyright © 2017 by Duke University Press.

  14. Optimización del proceso de bioadsorción de Cr (VI) mediante biomasa Opuntia


    Avilés González, María Dolores; Angosto, J.M.; Fernández López, José Antonio


    Centro Universitario de la Defensa. Escuela de Turismo de Cartagena. Escuela Técnica Superior de Ingeniería Industrial UPCT. Escuela Técnica Superior de Ingeniería de Telecomunicación (ETSIT). Escuela de Ingeniería de Caminos y Minas (EICM). Escuela de Arquitectura e Ingeniería de Edificación (ARQ&IDE). Parque Tecnológico de Fuente Álamo. Navantia. Campus Mare Nostrum. Estación Experimental Agroalimentaria Tomás Ferro. En este estudio se presentan las condiciones óptimas de operación para ...

  15. Disseny de la imatge d’una fruiteria “to take away”


    Pérez Zamora, Angel


    L’idea principal del projecte es crear l’identitat corporativa d’una empresa de restauració on es vendrà fruita tallada llesta per menjar-la, el model de restaurant conegut com a “take away”. Famós i conegut per empreses, la majoria d’elles franquícies, com: McDonalds, Starbucks, Telepizza, Burguer King, Pans & Company, Nostrum, Smöoy, Llaollao, Farggi, Olivier (aquestes quatre ultimes competència directe). El client a l’entrar dins de la botiga percebrà que esta en un lloc d’a...

  16. [Ether Day--no laughing matter. The birth of modern anaesthesia]. (United States)

    Goerig, Michael; Wulf, Hinnerk


    Since centuries the first public demonstration of the anaesthetic properties of ether by William Thomas Green Morton at the Massachusetts General Hospital in Boston on October 16th 1846 is celebrated as "Ether Day" world-wide. The news of the beneficial effects, primarily disposed as a "Yankee Invention", spread over all continents quickly. This was the result of an article, published in the Boston Medical and Surgical Journal on November 18th, 1846. It is mentioning worth that this article was written when Morton had disclosed that the used "preparation", later named as "Nostrum" or "Letheon", was sulphuric ether. The important discovery later became a patent case and was overshadowed by a long lasting priority claim. Nevertheless the readers of the New England Journal of Medicine voted in a survey that this article was the most important publication in the 200 years journals history ever. © Georg Thieme Verlag Stuttgart · New York.

  17. Venice and I: How a City Can Determine the Fate of a Career. (United States)

    Malanotte-Rizzoli, Paola


    Quoting the ancient Romans: Audentes Fortuna iuvat. Being in the right place at the right time is useless if you do not grasp your Fortuna and build upon it. In this article, I expound on the milestones of my multiform research career, which over more than 40 years brought me from Venice to California to MIT; from the Venice problem to highly nonlinear, coherent structures in the ocean and atmosphere; and from the mare nostrum (the Mediterranean Sea), a laboratory for global processes, to the tropical ocean-atmosphere systems and regional coupled climate models of the Maritime Continent. The climate system, with its daunting complexity, is arguably the greatest challenge for, and the future of, the entirety of the earth sciences. Finally, living in and working for Venice has been the privilege and Fortuna of my life.

  18. Psycho-socioeconomic factors affecting complementary and alternative medicine use among selected rural communities in Malaysia: a cross-sectional study. (United States)

    Ganasegeran, Kurubaran; Rajendran, Anantha Kumar; Al-Dubai, Sami Abdo Radman


    The use of complementary and alternative medicine (CAM) as a source of cure has gained much spectrum worldwide, despite skeptics and advocates of evidence-based practice conceptualized such therapies as human nostrum. This study aimed to explore the factors affecting CAM use among rural communities in Malaysia. A cross-sectional study was carried out on 288 occupants across four rural villages within the District of Selama, Perak, Malaysia. A survey that consisted of socio-economic characteristics, history of CAM use and the validated Holistic Complementary and Alternative Medicine Questionnaire (HCAMQ) were used. The prevalence of self-reported CAM use over the past one year was 53.1%. Multiple logistic regression analyses yielded three significant predictors of CAM use: monthly household income of less than MYR 2500, higher education level, and positive attitude towards CAM. Psycho-socioeconomic factors were significantly associated with CAM use among rural communities in Malaysia.

  19. Migration and determinants of health: clinical epidemiological characteristics of migrants in Malta (2010-11). (United States)

    Padovese, Valeska; Egidi, Ada Maristella; Melillo Fenech, Tanya; Podda Connor, Marika; Didero, Daniele; Costanzo, Gianfranco; Mirisola, Concetta


    Over recent years Malta has experienced a growing influx of migrants from Africa. With the aim of defining demographic characteristics and assessing the prevalence of conditions of public health significance among asylum seekers in Malta, a clinical research study was implemented in the framework of the European Union project 'Mare nostrum'. From August 2010 to June 2011 a dermatologist and an infectious diseases specialist performed general and specialist health assessment of migrants hosted in open centres. Migrants included in the study were 2216, 82.7% were males, their mean age was 25 years and 70.1% were from Somalia. Out of the total females, 42.5% had undergone some type of Female Genital Mutilation/Cutting. A total of 5077 diagnoses were set, most common were skin diseases (21.9%), respiratory diseases (19.8%) and gastro-enteric diseases (14.2%), whereas 31% of migrants reported good health conditions. Immigrants have a lower morbidity burden compared with their fellow countrymen living in the origin country. However, living conditions during the journey, in transit countries and after arrival can influence their health status. The present study provides a comprehensive picture of this growing population that is in need for health promotion, mental health services and fair policy planning. © The Author 2013. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail:

  20. Migrants, the EU and NGOs: The ‘Practice’ of Non-Governmental SAR Operations

    Directory of Open Access Journals (Sweden)

    Daniela Irrera


    Full Text Available Migration issues are dominating current debates at all levels. The perception of migrants as a threat quite often prevails over the human dimension and is associated to the immediate emergency management phase, particularly in respect of recent developments in the Mediterranean. The analysis of the roles of NGOs, a combination of traditional assistance to development and social integration and more active interventions i.e. Search and rescue operation in the Mediterranean may offer some interesting insights. The paper is a preliminary analysis of such trends, and is enriched by the results of an expert survey research on the performance of Mare Nostrum and its capacity to manage the crisis. There are three major considerations consisting in an assessment of the literature on the role played by NGOs in EU migration policies, an analysis of the use of SAR by different actors, including the non-governmental, in order to investigate the impact on the management of the crisis and finally empirical data which are used to assess current trends and raise future perspectives.

  1. Structural Biology in the context of EGEE

    CERN Document Server

    García, D; Carazo, J M; Valverde, J R; Moscicki, J; Muraru, A


    Electron microscopy (EM) is a crucial technique, which allows Structural Biology researchers to characterize macromolecular assemblies in distinct functional states. Image processing in three dimensional EM (3D-EM) is used by a flourishing community (exemplarized by the EU funded 3D-EM NoE) and is characterized by voluminous data and large computing requirements, making this a problem well suited for Grid computing and the EGEE infrastructure. There are various steps in the 3D-EM refinement process that may benefit from Grid computing. To start with, large numbers of experimental images need to be averaged. Nowadays, typically tens of thousands of images are used, while future studies may routinely employ millions of images. Our group has been developing Xmipp, a package for single-particle 3D-EM image processing. Using Xmipp, the classification of 91,000 ribosome projections into 4 classes took more than 2500 CPU hours using the resources of the MareNostrum supercomputer at the Barcelona Supercomputing Centr...

  2. Earth system modelling on system-level heterogeneous architectures: EMAC (version 2.42) on the Dynamical Exascale Entry Platform (DEEP) (United States)

    Christou, Michalis; Christoudias, Theodoros; Morillo, Julián; Alvarez, Damian; Merx, Hendrik


    We examine an alternative approach to heterogeneous cluster-computing in the many-core era for Earth system models, using the European Centre for Medium-Range Weather Forecasts Hamburg (ECHAM)/Modular Earth Submodel System (MESSy) Atmospheric Chemistry (EMAC) model as a pilot application on the Dynamical Exascale Entry Platform (DEEP). A set of autonomous coprocessors interconnected together, called Booster, complements a conventional HPC Cluster and increases its computing performance, offering extra flexibility to expose multiple levels of parallelism and achieve better scalability. The EMAC model atmospheric chemistry code (Module Efficiently Calculating the Chemistry of the Atmosphere (MECCA)) was taskified with an offload mechanism implemented using OmpSs directives. The model was ported to the MareNostrum 3 supercomputer to allow testing with Intel Xeon Phi accelerators on a production-size machine. The changes proposed in this paper are expected to contribute to the eventual adoption of Cluster-Booster division and Many Integrated Core (MIC) accelerated architectures in presently available implementations of Earth system models, towards exploiting the potential of a fully Exascale-capable platform.

  3. Interstellar rendezvous missions employing fission propulsion systems

    International Nuclear Information System (INIS)

    Lenard, Roger X.; Lipinski, Ronald J.


    There has been a conventionally held nostrum that fission system specific power and energy content is insufficient to provide the requisite high accelerations and velocities to enable interstellar rendezvous missions within a reasonable fraction of a human lifetime. As a consequence, all forms of alternative mechanisms that are not yet, and may never be technologically feasible, have been proposed, including laser light sails, fusion and antimatter propulsion systems. In previous efforts, [Lenard and Lipinski, 1999] the authors developed an architecture that employs fission power to propel two different concepts: one, an unmanned probe, the other a crewed vehicle to Alpha Centauri within mission times of 47 to 60 years. The first portion of this paper discusses employing a variant of the ''Forward Resupply Runway'' utilizing fission systems to enable both high accelerations and high final velocities necessary for this type of travel. The authors argue that such an architecture, while expensive, is considerably less expensive and technologically risky than other technologically advanced concepts, and, further, provides the ability to explore near-Earth stellar systems out to distances of 8 light years or so. This enables the ability to establish independent human societies which can later expand the domain of human exploration in roughly eight light-year increments even presuming that no further physics or technology breakthroughs or advances occur. In the second portion of the paper, a technology requirement assessment is performed. The authors argue that reasonable to extensive extensions to known technology could enable this revolutionary capability

  4. Lethal Lullabies: A History of Opium Use in Infants. (United States)

    Obladen, Michael


    Poppy extract accompanied the human infant for more than 3 millenia. Motives for its use included excessive crying, suspected pain, and diarrhea. In antiquity, infantile sleeplessness was regarded as a disease. When treatment with opium was recommended by Galen, Rhazes, and Avicenna, baby sedation made its way into early medical treatises and pediatric instructions. Dabbing maternal nipples with bitter substances and drugging the infant with opium were used to hasten weaning. A freerider of gum lancing, opiates joined the treatment of difficult teething in the 17th century. Foundling hospitals and wet-nurses used them extensively. With industrialization, private use was rampant among the working class. In German-speaking countries, poppy extracts were administered in soups and pacifiers. In English-speaking countries, proprietary drugs containing opium were marketed under names such as soothers, nostrums, anodynes, cordials, preservatives, and specifics and sold at the doorstep or in grocery stores. Opium's toxicity for infants was common knowledge; thousands of cases of lethal intoxication had been reported from antiquity. What is remarkable is that the willingness to use it in infants persisted and that physicians continued to prescribe it for babies. Unregulated trade, and even that protected by governments, led to greatly increased private use of opiates during the 19th century. Intoxication became a significant factor in infant mortality. As late as 1912, the International Hague Convention forced governments to implement legislation that effectively curtailed access to opium and broke the dangerous habit of sedating infants. © The Author(s) 2015.

  5. Two Jungs. Apropos a paper by Mark Saban. (United States)

    Giegerich, Wolfgang


    Jung's idea of the 'personal equation' amounts to the reflection that theoretical differences between the psychologies that people teach are rooted in their personalities, in other words, that they are due to the psychology each one 'has'. This concept also applies to different interpretations of Jung's work. The serious difficulties that Mark Saban has with my psychology are a case in point. Recourse to the concept of the personal equation reveals that Saban has his Jung and I have mine. With his insistence on his Talmudic methodological principle of dream interpretation, that 'the dream is its own interpretation', according to Saban Jung means nothing but a rejection of Freudian free association. My Jung goes far beyond that. Jung understands this methodological principle above all in terms of what he calls 'circumambulation'. The main part of this paper is devoted to an elucidation of what circumambulation involves as a mode of dream interpretation. The paper concludes with the distinction Jung himself introduced between two types of reading of his work, either as 'paper' and 'dead nostrums' or as 'fire and wind', and pleads for a reconstruction of Jung's psychology as a whole in terms of his most advanced, deepest insights, instead of a dogmatic reading mainly based on the early Jung, a reading for which his later revolutionary insights are at best negligible embellishments. © 2015, The Society of Analytical Psychology.

  6. Amniotic membrane-derived stem cells: immunomodulatory properties and potential clinical application

    Directory of Open Access Journals (Sweden)

    Insausti CL


    Full Text Available Carmen L Insausti,1 Miguel Blanquer,1 Ana M García-Hernández,1 Gregorio Castellanos,2 José M Moraleda11Unidad de Trasplante Hematopoyético y Terapia Celular, 2Servicio de Cirugía, Hospital Clínico Universitario Virgen de la Arrixaca, IMIB, Campus Mare Nostrum, Universidad de Murcia, El Palmar, Murcia, SpainAbstract: Epithelial and mesenchymal cells isolated from the amniotic membrane (AM possess stem cell characteristics, differentiation potential toward lineages of different germ layers, and immunomodulatory properties. While their expansion and differentiation potential have been well studied and characterized, knowledge about their immunomodulatory properties and the mechanisms involved is still incomplete. These mechanisms have been evaluated on various target cells of the innate and the adaptive system and in animal models of different inflammatory diseases. Some results have evidenced that the immunomodulatory effect of AM-derived cells is dependent on cell-cell contact, but many of them have demonstrated that these properties are mediated through the secretion of suppressive molecules. In this review, we present an update on the described immunomodulatory properties of the derived amniotic cells and some of the proposed involved mechanisms. Furthermore, we describe some assays in animal models of different inflammatory diseases which reveal the potential use of these cells to treat such diseases.Keywords: epithelial cells, mesenchymal cells, cell therapy, immunomodulation

  7. Radithor and the era of mild radium therapy

    International Nuclear Information System (INIS)

    Macklis, R.M.


    Soon after the discovery of radium, a school of practitioners arose who were interested primarily in the physiological rather than the tumoricidal powers of this new radioactive element. This treatment philosophy was called mild radium therapy and involved the oral or parenteral administration of microgram quantities of radium and its daughter isotopes, often as cures for rheumatic diseases, hypertension, and metabolic disorders. Manufacturers of patent medicines responded to this market by producing a variety of over-the-counter radioactive preparations including pills, elixirs, and salves. One such nostrum was Radithor, a popular and expensive mixture of radium 226 and radium 228 in distilled water. Radithor was advertised as an effective treatment for over 150 endocrinologic diseases, especially lassitude and sexual impotence. Over 400,000 bottles, each containing over 2 muCi (74 kBq) of radium, were apparently marketed and sold worldwide between 1925 and 1930. The death of the Pittsburgh millionaire sportsman Eben M. Byers, who was an avid Radithor user, by radium poisoning in 1932 brought an end to this era and prompted the development of regulatory controls for all radiopharmaceuticals

  8. [Established treatment options for male stress urinary incontinence]. (United States)

    Hampel, C; Gillitzer, R; Wiesner, C; Thüroff, J W


    Nowadays, male stress urinary incontinence is rare and almost always of iatrogenic origin (radiotherapy, pelvic surgery). However, the prognosis of urinary incontinence following surgery is good and can be improved by pelvic floor muscle exercises in combination with biofeedback systems. For the remaining patient cohort with persistent urinary incontinence, several established surgical treatment options are available. Suburothelial injections of bulking agents can easily be performed in an ambulatory setting. However, regardless of the material used, long-term results are disappointing. Moreover, the residual urethral function deteriorates due to cicatrization of the suburothelial plexus with consequent loss of urethral elasticity. The fascial sling procedure in males has to be performed in preoperated areas and is as technically demanding for the surgeon as it is burdening for the patient. Alloplastic material is not used, thus minimizing risks for arrosion or infection. Since the sling tension can neither be standardized nor postoperatively readjusted, the risk of overcorrection is considerable and the success of the procedure is heavily dependent on the surgeon's experience. Despite wear and high revision rates, the technically mature artificial sphincter produces excellent continence results and has become the gold standard in the therapy of male stress urinary incontinence. The circumferential and continuous urethral compression by the cuff is highly effective, but at the price of an almost inevitable urethral atrophy. To overcome this problem, various surgical techniques have been developed (tandem cuff, cuff downsizing, transcorporal cuff placement). However, the expensive artificial sphincter is not a nostrum for every incontinent man, since it requires certain minimal cognitive and manual capabilities. Therefore, the search for less demanding treatment alternatives seems to be necessary, even if one has to accept lower continence rates.

  9. Tra Storia eMito: L’ossimoro Siciliano Secondo Gesualdo Bufalino

    Directory of Open Access Journals (Sweden)

    Flaviano Pisanelli


    Full Text Available Definindo-se um “siciliano europeu”, Gesualdo Bufalino, em sua obra literária e poética (especialmente em L’amaro miele e Museo d’ombre assim como em seus inúmeros artigos jornalísticos e intervenções críticas reunidos em volume (Cere perse, La luce e il lutto, elabora sonoridades e significados que tentam devolver as nuances cromáticas e a imagem em formato de mosaico de uma Sicília que não é apenas “metáfora” - como Leonardo Sciascia escreveu – de uma civilização mediterrânea em contínua transformação, mas também um espaço em que, por meio do dispositivo da memória, é possível revisitar um patrimônio histórico e cultural, material e imaterial, capaz de se afirmar como principio identitário em constante evolução. Nessa perspectiva, o espaço insular siciliano se torna uma fonte inesgotável de representações e autorrepresentações nas quais Bufalino desenvolve uma poética personalíssima e um imaginário que devolvem à Sicília sua vocação natural de “ilha-ponte” e de “ilha-plural” desde sempre influenciada pelo racionalismo europeu e por uma espécie de magismo mítico que sopra com força das margens sulistas do mare nostrum

  10. Development and application of a free energy force field for all atom protein folding

    International Nuclear Information System (INIS)

    Verma, A.


    Proteins are the workhorses of all cellular life. They constitute the building blocks and the machinery of all cells and typically function in specific three-dimensional conformations into which each protein folds. Currently over one million protein sequences are known, compared to about 40,000 structures deposited in the Protein Data Bank (the world-wide database of protein structures). Reliable theoretical methods for protein structure prediction could help to reduce the gap between sequence and structural databases and elucidate the biological information in structurally unresolved sequences. In this thesis we explore an approach for protein structure prediction and folding that is based on the Anfinsen's hypothesis that most proteins in their native state are in thermodynamic equilibrium with their environment. We have developed a free energy forcefield (PFF02) that locates the native conformation of many proteins from all structural classes at the global minimum of the free-energy model. We have validated the forcefield against a large decoy set (Rosetta). The average root mean square deviation (RMSD) for the lowest energy structure for the 32 proteins of the decoy set was only 2.14 Aa from the experimental conformation. We have successfully implemented and used stochastic optimization methods, such as the basin hopping technique and evolutionary algorithms for all atom protein structure prediction. The evolutionary algorithm performs exceptionally well on large supercomputational architectures, such as BlueGene and MareNostrum. Using the PFF02 forcefield, we were able to fold 13 proteins (12-56 amino acids), which include helix, sheet and mixed secondary structure. On average the predicted structure of these proteins deviated from their experimental conformation by only 2.89 Aa RMSD. (orig.)

  11. The Journal “Geopolitica” and Formation of the Italian Geopolitical School

    Directory of Open Access Journals (Sweden)

    Maximilian Al’bertovich Shepelev


    Full Text Available The article reveals the origins, methodological features and the process of institutionalization of Italian geopolitical school, place and role of the journal “Geopolitica” in this process. The article analyzes the characteristics of Italian geopolitical perception of the world and its geostrategic priorities, formulated by the representatives of the Italian geopolitical schools in the period of its formation in 20-40-ies of the XX century (the Mediterranean - Mare nostrum, Euroafrica. The source of the formation of the Italian geopolitical school was the intellectual influence of irredentism un the age of the Risorgimento. The process of its formation was correlated with the formation of the modern national school of geographical science, in which was dominated the perception of geography as “utilitarian science” and developed the direction of “dynamic political geography”. Its specifical features was the “antideterminism” and “geographic humanism”, the recognition that the environment does not have absolute power over society, but political will is a determining factor in anthropogeographical area. The institutionalization of Italian political school promoted the creation of several research centres in the 20-30-ies and publishing from January 1939 to December 1942 magazine “Geopolitica”. The draft edition of this magazine received support from the minister of national education Giuseppe Bottai, it was headed by Professor Giorgio Roletto and his disciple, Ernesto Massi. Italian geopolitics maintained close ties with their German colleagues, but they were theoretically justified differences between “Latin” and “German” geopolitical worldviews. Unlike the German geopolitics, the concept of “living space” was used primarily in the economic sense, but it was not used in a racial-demographic sense. Italian geopolitics acted against the world order enshrined in the Treaty of Versailles, because it was protected

  12. Reseña. Al Cabo de las Velas. Expediciones Científicas en Colombia. Siglos XVIII, XIX y XX

    Directory of Open Access Journals (Sweden)

    Efraim Otero Ruiz


    Full Text Available

    Acogemos como Miembro de la Sociedad Colombiana de Historia de la Medicina a un joven científico cuyas inquietudes investigativas, instiladas desde la casa paterna, lo han llevado a explorar desde lo infinitamente pequeño hasta lo prodigiosamente grande, desde el microcosmos hasta el macrocosmos: yen cada ocasión dejando huella de su talento, primero como graduando en Bioquímica e Inmunología de la Sorbona y del Instituto Pasteur y después como investigador del Instituto de Genética Humana de la Universidad Javeriana.

    Pero es el resultado de una de sus actividades macrocósmicas, la de la Expedición Humana, lo que nos lo trae aquí esta noche al presentarnos el libro de las grandes Expediciones en Colombia, que él ha titulado “Al Cabo de las Velas-Expediciones Científicas en Colombia, Siglos XVIII, XIX Y XX”.

    Efectivamente los viajes clásicos, tal como hoy los conocemos por los historiadores o los cronistas, se dividieron en “exploraciones” y “expediciones”, según aquellas se dedicaran a recorrer los diferentes territorios y sus accidentes geográficos y a describirlos en forma más o menos detallada para el beneficio de futuros viajeros; mientras que éstas se formaban por grupos selectos, dirigidos a lugares geográficos definidos y dotados de un fin específico, para registrar, colonizar, analizar o explotar sus recursos.

    Esa definición, sin embargo, se confunde en la práctica; tecnológicamente, los viajes marinos sólo se harán posibles cuando el diseño de voluminosas embarcaciones con quilla y timón, con suficiente velamen y capacidad para albergar un número grande de fornidos remeros les permitiera, no sólo transportar las provisiones suficientes de agua, comida, algunas armas e implementos, sino poder sortear las inconsistencias y las inclemencias del tiempo, desde las calmas chichas hasta los huracanes.

    Por eso los viajes clásicos se inician en el Mare Nostrum, en Creta y en

  13. Radiation beamline testbeds for the simulation of planetary and spacecraft environments for human and robotic mission risk assessment (United States)

    Wilkins, Richard

    The Center for Radiation Engineering and Science for Space Exploration (CRESSE) at Prairie View A&M University, Prairie View, Texas, USA, is establishing an integrated, multi-disciplinary research program on the scientific and engineering challenges faced by NASA and the inter-national space community caused by space radiation. CRESSE focuses on space radiation research directly applicable to astronaut health and safety during future long term, deep space missions, including Martian, lunar, and other planetary body missions beyond low earth orbit. The research approach will consist of experimental and theoretical radiation modeling studies utilizing particle accelerator facilities including: 1. NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory; 2. Proton Synchrotron at Loma Linda University Med-ical Center; and 3. Los Alamos Neutron Science Center (LANSCE) at Los Alamos National Laboratory. Specifically, CRESSE investigators are designing, developing, and building experimental test beds that simulate the lunar and Martian radiation environments for experiments focused on risk assessment for astronauts and instrumentation. The testbeds have been designated the Bioastronautics Experimental Research Testbeds for Environmental Radiation Nostrum Investigations and Education (BERT and ERNIE). The designs of BERT and ERNIE will allow for a high degree of flexibility and adaptability to modify experimental configurations to simulate planetary surface environments, planetary habitats, and spacecraft interiors. In the nominal configuration, BERT and ERIE will consist of a set of experimental zones that will simulate the planetary atmosphere (Solid CO2 in the case of the Martian surface.), the planetary surface, and sub-surface regions. These experimental zones can be used for dosimetry, shielding, biological, and electronic effects radiation studies in support of space exploration missions. BERT and ERNIE are designed to be compatible with the

  14. The Evaluation of the Spanish Air Quality Modelling System: CALIOPE. Dynamics and Chemistry over Europe and Iberian Peninsula for 2004 at high horizontal resolution (United States)

    Piot, M.; Pay, M.; Jorba, O.; Lopez, E.; Pirez, C.; Gasso, S.; Baldasano, J. M.


    In Europe, human exposure to air pollution often exceeds standards set by the EU commission (Directives 1996/62/EC, 2002/3/EC, 2008/50/EC) and the World Health Organization (WHO). Urban/suburban areas are predominantly impacted upon, although exceedances of particulate matter (PM10 and PM2.5) and Ozone (O3) also take place in rural areas. Within the CALIOPE project, a high-resolution air quality forecasting system, namely WRF-ARW/HERMES04/CMAQ/BSC-DREAM, has been developed and applied to the European domain (12x12 sq. km, 1hr) as well as the Spanish domain (4x4 sq. km, 1hr). The simulation of such high-resolution model system has been made possible by its implementation on the MareNostrum supercomputer. This contribution describes a thorough quantitative evaluation study performed for the reference year 2004. The WRF-ARW meteorological model contains 38 vertical layers reaching up to 50 hPa. The vertical resolution of the CMAQ chemistry-transport model for gas-phase and aerosols has been increased from 8 to 15 layers in order to simulate vertical exchanges more accurately. Gas phase boundary conditions are provided by the LMDz-INCA2 global climate-chemistry model. For the European simulation, emissions are disaggregated from the EMEP emission inventory for 2004 to the utilized resolution using the criteria implemented in the HERMES04 emission model. The HERMES04 model system, running through a bottom-up approach, is used to estimate emissions for Spain at a 1x1 sq. km horizontal resolution, every hour. In order to evaluate the performances of the CALIOPE system, the model simulation for Europe was compared with ground-based measurements from the EMEP and the Spanish air quality networks (total of 60 stations for O3, 43 for NO2, 31 for SO2, 25 for PM10 and 16 for PM2.5). The model simulation for Europe satisfactorily reproduces O3 concentrations throughout the year (annual correlation: 0.66) with relatively small errors: MNGE values range from 13% to 26%, and MNBE

  15. Migration, Socially Engaged Museum Theme, and Why Slovenian Museums Successfully Avoid it?

    Directory of Open Access Journals (Sweden)

    Verena Perko


    Full Text Available In the last year, the refugee crisis has turned into a human tragedy, in many ways resembling that of World War Two. The Mediterranean Sea, the highly praised Mare Nostrum, has become a horrifying collective tomb for countless people. Another consequence of war is also the destruction of historical urban centres, monuments, and other cultural heritage in so-called crisis areas – a destruction which has reached unfathomable proportions. Museums all across the world have actively responded to society’s needs. Their goal has been to encourage an open dialogue in our society, as well as alleviate fear of the unknown, and reduce the tide of hatred before it reaches world-shattering proportions. During the refugee crisis, it has become apparent that an intersocietal dialogue is both a necessity and a definitive imperative; without it, the society of the future cannot possibly be assured. Modern society has given museums the role of being a credible medium with a mission to communicate heritage contents. By using a metaphorical and metonymic language museums have an extraordinary social power and represent a bridge between science and modern society, between societies of the past and present, between the elites and marginal groups. The museum reformers of the second half of the 20th century were of the opinion that, despite many reorganizations, museums cannot serve the needs of modern society. This was the reason a new museology emerged that substantiates museums as a socially responsible institution. It equips that institution with specific theoretical knowledge that enables the conversion of heritage into a socially relevant communication of a nonverbal nature. The article theoretically argues for modern museum concepts and, using them, contemplates social responsibility in the inner workings of Slovenian museums. Contemporary museums or post-museums are institutions that carry out active social tasks. An engaged manner brings along social

  16. Air quality over Europe and Iberian Peninsula for 2004 at high horizontal resolution: evaluation of the CALIOPE modelling system (United States)

    Jorba, O.; Piot, M.; Pay, M. T.; Jiménez-Guerrero, P.; López, E.; Pérez, C.; Gassó, S.; Baldasano, J. M.


    In the frame of the CALIOPE project (Baldasano et al., 2008a), a high-resolution air quality forecasting system, WRF-ARW/HERMES/CMAQ/DREAM, is under development and applied to the European domain (12km x 12km, 1hr) as well as to the Iberian Peninsula domain (4km x 4km, 1hr) to provide air quality forecasts for Spain ( The simulation of such high-resolution model system is possible by its implementation on the MareNostrum supercomputer. To reassure potential users and reduce uncertainties, the model system must be evaluated to assess its performances in terms of air quality levels and dynamics reproducibility. The present contribution describes a thorough quantitative evaluation study performed for a reference year (2004). CALIOPE is a complex system that integrates a variety of environmental models. WRF-ARW provides high-resolution meteorological fields to the system. It is configured with 38 vertical layers reaching up to 50 hPa. Meteorological initial and boundary conditions are obtained from the NCEP final analysis data. The HERMES emission model (Baldasano et al., 2008b) computes the emissions for the Iberian Peninsula simulation at 4 km horizontal resolution every hour using a bottom-up approach. For the European domain, HERMES disaggregates the EMEP expert emission inventory for 2004. The CMAQ chemical transport model solves the physico-chemical processes in the system. The vertical resolution of CMAQ for gas-phase and aerosols has been increased from 8 to 15 layers in order to simulate vertical exchanges more accurately. Chemical boundary conditions are provided by the LMDz-INCA2 global climate-chemistry model (see Hauglustaine et al., 2004). Finally, the DREAM model simulates long-range transport of mineral dust over the domains under study. In order to evaluate the performances of the CALIOPE system, model simulations were compared with ground-based measurements from the EMEP and Spanish air quality networks. For the European

  17. Evaluating the CALIOPE air quality modelling system: dynamics and chemistry over Europe and Iberian Peninsula for 2004 at high horizontal resolution (United States)

    Piot, M.; Pay, M. T.; Jorba, O.; Baldasano, J. M.; Jiménez-Guerrero, P.; López, E.; Pérez, C.; Gassó, S.


    Often in Europe, population exposure to air pollution exceeds standards set by the EU and the World Health Organization (WHO). Urban/suburban areas are predominantly impacted upon, although exceedances of particulate matter (PM10 and PM2.5) and Ozone (O3) also take place in rural areas. In the frame of the CALIOPE project (Baldasano et al., 2008a), a high-resolution air quality forecasting system, WRF-ARW/HERMES/CMAQ/DREAM, has been developed and applied to the European domain (12km x 12km, 1hr) as well as to the Iberian Peninsula domain (4km x 4km, 1hr) to provide air quality forecasts for Spain ( The simulation of such high-resolution model system has been made possible by its implementation on the MareNostrum supercomputer. To reassure potential users and reduce uncertainties, the model system must be evaluated to assess its performances in terms of air quality levels and dynamics reproducibility. The present contribution describes a thorough quantitative evaluation study performed for a reference year (2004). The CALIOPE modelling system is configured with 38 vertical layers reaching up to 50 hPa for the meteorological core. Atmospheric initial and boundary conditions are obtained from the NCEP final analysis data. The vertical resolution of the CMAQ chemistry-transport model for gas-phase and aerosols has been increased from 8 to 15 layers in order to simulate vertical exchanges more accurately. Gas phase boundary conditions are provided by the LMDz-INCA2 global climate-chemistry model (see Hauglustaine et al., 2004). The DREAM model simulates long-range transport of mineral dust over the domains under study. For the European simulation, emissions are disaggregated from the EMEP expert emission inventory for 2004 to the utilized resolution using the criteria implemented in the HERMES emission model (Baldasano et al., 2008b). The HERMES model system, using a bottom-up approach, was adopted to estimate emissions for the Iberian

  18. 32nd International Austrian Winter Symposium : Zell am See, the Netherlands. 20-23 January 2016. (United States)

    Langsteger, W; Rezaee, A; Loidl, W; Geinitz, H S; Fitz, F; Steinmair, M; Broinger, G; Pallwien-Prettner, L; Beheshti, M; Imamovic, L; Beheshti, M; Rendl, G; Hackl, D; Tsybrovsky, O; Steinmair, M; Emmanuel, K; Moinfar, F; Pirich, C; Langsteger, W; Bytyqi, A; Karanikas, G; Mayerhöfer, M; Koperek, O; Niederle, B; Hartenbach, M; Beyer, T; Herrmann, K; Czernin, J; Rausch, I; Rust, P; DiFranco, M D; Lassen, M; Stadlbauer, A; Mayerhöfer, M E; Hartenbach, M; Hacker, M; Beyer, T; Binzel, K; Magnussen, R; Wei, W; Knopp, M U; Flanigan, D C; Kaeding, C; Knopp, M V; Leisser, A; Nejabat, M; Hartenbach, M; Kramer, G; Krainer, M; Hacker, M; Haug, A; Lehnert, Wencke; Schmidt, Karl; Kimiaei, Sharok; Bronzel, Marcus; Kluge, Andreas; Wright, C L; Binzel, K; Zhang, J; Wuthrick, Evan; Maniawski, Piotr; Knopp, M V; Blaickner, M; Rados, E; Huber, A; Dulovits, M; Kulkarni, H; Wiessalla, S; Schuchardt, C; Baum, R P; Knäusl, B; Georg, D; Bauer, M; Wulkersdorfer, B; Wadsak, W; Philippe, C; Haslacher, H; Zeitlinger, M; Langer, O; Bauer, M; Feldmann, M; Karch, R; Wadsak, W; Zeitlinger, M; Koepp, M J; Asselin, M-C; Pataraia, E; Langer, O; Zeilinger, M; Philippe, C; Dumanic, M; Pichler, F; Pilz, J; Hacker, M; Wadsak, W; Mitterhauser, M; Nics, L; Steiner, B; Hacker, M; Mitterhauser, M; Wadsak, W; Traxl, A; Wanek, Thomas; Kryeziu, Kushtrim; Mairinger, Severin; Stanek, Johann; Berger, Walter; Kuntner, Claudia; Langer, Oliver; Mairinger, S; Wanek, T; Traxl, A; Krohn, M; Stanek, J; Filip, T; Sauberer, M; Kuntner, C; Pahnke, J; Langer, O; Svatunek, D; Denk, C; Wilkovitsch, M; Wanek, T; Filip, T; Kuntner-Hannes, C; Fröhlich, J; Mikula, H; Denk, C; Svatunek, D; Wanek, T; Mairinger, S; Stanek, J; Filip, T; Fröhlich, J; Mikula, H; Kuntner-Hannes, C; Balber, T; Singer, J; Fazekas, J; Rami-Mark, C; Berroterán-Infante, N; Jensen-Jarolim, E; Wadsak, W; Hacker, M; Viernstein, H; Mitterhauser, M; Denk, C; Svatunek, D; Sohr, B; Mikula, H; Fröhlich, J; Wanek, T; Kuntner-Hannes, C; Filip, T; Pfaff, S; Philippe, C; Mitterhauser, M; Hartenbach, M; Hacker, M; Wadsak, W; Wanek, T; Halilbasic, E; Visentin, M; Mairinger, S; Stieger, B; Kuntner, C; Trauner, M; Langer, O; Lam, P; Aistleitner, M; Eichinger, R; Artner, C; Eidherr, H; Vraka, C; Haug, A; Mitterhauser, M; Nics, L; Hartenbach, M; Hacker, M; Wadsak, W; Kvaternik, H; Müller, R; Hausberger, D; Zink, C; Aigner, R M; Cossío, U; Asensio, M; Montes, A; Akhtar, S; Te Welscher, Y; van Nostrum, R; Gómez-Vallejo, V; Llop, J; VandeVyver, F; Barclay, T; Lippens, N; Troch, M; Hehenwarter, L; Egger, B; Holzmannhofer, J; Rodrigues-Radischat, M; Pirich, C; Pötsch, N; Rausch, I; Wilhelm, D; Weber, M; Furtner, J; Karanikas, G; Wöhrer, A; Mitterhauser, M; Hacker, M; Traub-Weidinger, T; Cassou-Mounat, T; Balogova, S; Nataf, V; Calzada, M; Huchet, V; Kerrou, K; Devaux, J-Y; Mohty, M; Garderet, L; Talbot, J-N; Stanzel, S; Pregartner, G; Schwarz, T; Bjelic-Radisic, V; Liegl-Atzwanger, B; Aigner, R; Stanzel, S; Quehenberger, F; Aigner, R M; Marković, A Koljević; Janković, Milica; Jerković, V Miler; Paskaš, M; Pupić, G; Džodić, R; Popović, D; Fornito, M C; Familiari, D; Koranda, P; Polzerová, H; Metelková, I; Henzlová, L; Formánek, R; Buriánková, E; Kamínek, M; Thomson, W H; Lewis, C; Thomson, W H; O'Brien, J; James, G; Notghi, A; Huber, H; Stelzmüller, I; Wunn, R; Mandl, M; Fellner, F; Lamprecht, B; Gabriel, M; Fornito, M C; Leonardi, G; Thomson, W H; O'Brien, J; James, G; Hudzietzová, J; Sabol, J; Fülöp, M


    -through reactorS Pfaff, C Philippe, M Mitterhauser, M Hartenbach, M Hacker, W WadsakA22 Influence of 24-nor-ursodeoxycholic acid on hepatic disposition of [18F]ciprofloxacin measured with positron emission tomographyT Wanek, E Halilbasic, M Visentin, S Mairinger, B Stieger, C Kuntner, M Trauner, O LangerA23 Automated 18F-flumazenil production using chemically resistant disposable cassettesP Lam, M Aistleitner, R Eichinger, C ArtnerA24 Similarities and differences in the synthesis and quality control of 177Lu-DOTA-TATE, 177Lu -HA-DOTA-TATE and 177Lu-DOTA-PSMA (PSMA-617)H Eidherr, C Vraka, A Haug, M Mitterhauser, L Nics, M Hartenbach, M Hacker, W WadsakA25 68Ga- and 177Lu-labelling of PSMA-617H Kvaternik, R Müller, D Hausberger, C Zink, RM AignerA26 Radiolabelling of liposomes with 67Ga and biodistribution studies after administration by an aerosol inhalation systemU Cossío, M Asensio, A Montes, S Akhtar, Y te Welscher, R van Nostrum, V Gómez-Vallejo, J LlopA27 Fully automated quantification of DaTscan SPECT: Integration of age and gender differencesF VandeVyver, T Barclay, N Lippens, M TrochA28 Lesion-to-background ratio in co-registered 18F-FET PET/MR imaging - is it a valuable tool to differentiate between low grade and high grade brain tumor?L Hehenwarter, B Egger, J Holzmannhofer, M Rodrigues-Radischat, C PirichA29 [11C]-methionine PET in gliomas - a retrospective data analysis of 166 patientsN Pötsch, I Rausch, D Wilhelm, M Weber, J Furtner, G Karanikas, A Wöhrer, M Mitterhauser, M Hacker, T Traub-WeidingerA30 18F-Fluorocholine versus 18F-Fluorodeoxyglucose for PET/CT imaging in patients with relapsed or progressive multiple myeloma: a pilot studyT Cassou-Mounat, S Balogova, V Nataf, M Calzada, V Huchet, K Kerrou, J-Y Devaux, M Mohty, L Garderet, J-N TalbotA31 Prognostic benefit of additional SPECT/CT in sentinel lymph node mapping of breast cancer patientsS Stanzel, G Pregartner, T Schwarz, V Bjelic-Radisic, B Liegl-Atzwanger, R AignerA32 Evaluation of diagnostic value