WorldWideScience

Sample records for nos imas permanentes

  1. A educação permanente da equipe de enfermagem para o cuidado nos serviços de saúde mental

    OpenAIRE

    Tavares,Cláudia Mara de Melo

    2006-01-01

    Estudio exploratório, cuyo objetivo fue analizar la necesidad de la educación permanente del equipo de enfermera para cuidar en los servicios de la salud mental. Fueron estudiadas treinta siete profesionales de enfermería mental. Como resultados, se verificó que él equipe de la enfermería demanda calificación de vasto espectro. Se concluye que la educación permanente del equipo del oficio de enfermera de la salud mental exige más allá de programas educativos establecidos en la def...

  2. The permanental process

    DEFF Research Database (Denmark)

    McCullagh, Peter; Møller, Jesper

    2006-01-01

    We extend the boson process first to a large class of Cox processes and second to an even larger class of infinitely divisible point processes. Density and moment results are studied in detail. These results are obtained in closed form as weighted permanents, so the extension i called a permanental...... process. Temporal extensions and a particularly tractable case of the permanental process are also studied. Extensions of the fermion process along similar lines, leading to so-called determinantal processes, are discussed....

  3. Academic formation and permanent education: influences on leadership styles of nurses Formação acadêmica e educação permanente: influências nos estilos de liderança de enfermeiros

    Directory of Open Access Journals (Sweden)

    Karen Cristina Kades Andrigue

    2017-10-01

    Full Text Available Objetivo: conhecer as influências da formação acadêmica e da Educação Permanente em Saúde (EPS nos estilos de liderança adotados pelos enfermeiros no âmbito hospitalar. Método: pesquisa qualitativa do tipo descritiva, apoiada no referencial de Hersey e Blanchard. Participaram do estudo seis enfermeiros da rede hospitalar de Chapecó (SC, que tipificavam diferentes estilos de liderança. Os dados foram coletados por meio de entrevistas semiestruturadas e analisados conforme Análise Temática. Resultados: os participantes sentiram-se pouco influenciados para liderar diante da formação obtida na graduação e ressaltaram dificuldades de integração ensino-serviço, que interferiram no exercício da liderança. Quanto à EPS, sinalizaram a falta de investimentos na qualificação. Conclusão: destaca-se a importância de o ensino na graduação fortalecer as práticas de aprendizagem da liderança e entende-se que a liderança é aperfeiçoada ao longo da vida profissional.    Objective: to know the influences of academic training and Continuing Health Education (EPS on the leadership styles adopted by nurses in the hospital environment. Method: it is qualitative descriptive-type research supported in the references of Hersey and Blanchard. Six nurses from the hospital network of Chapecó, Santa Catarina, participated in this study and typified different leadership styles. The data were collected through semi-structured interviews and analyzed according to Thematic Analysis. Results: the participants felt only slightly influenced to lead during the training obtained in their graduation course and highlighted difficulties in integrating education service, which interfered in exercising leadership. As for the Continuing Health Education (EPS, it indicated a lack of investment in qualification. Conclusion: standing it was highlighted the importance of education in graduation studies to strengthen leadership learning practices and it is

  4. Mediación de la cultura docente en los proyectos de formación permanente (Mediation of culture teaching in lifelong learning projects (Médiation de la culture de l'enseignant dans les projets de formation continue (Mediação da cultura docente nos projectos de formação permanente

    Directory of Open Access Journals (Sweden)

    Rosa Amaya-de Rebolledo

    2010-12-01

    Full Text Available ResumenLa formación permanente del docente juega un papel clave en el cambio educativo; sin embargo, su con- creción práctica representa un reto epistemológico y metodológico. La problemática ha sido abordada des- de diferentes ángulos, en los cuales la relación entre cultura docente y formación permanente no ha sido claramente desvelada. En este artículo, que constituye un avance en la investigación de tesis doctoral de la Facultad de Ciencias de la Educación de la Universidad de Carabobo, se analiza por qué la cultura docente necesita ser reconocida como una realidad dinámica, dialéctica y relacional que afecta la calidad de la for- mación permanente del docente venezolano.AbstractThe continuous training of the teacher plays a key role in educational change; however, to take it to the practice rep- resents an epistemological and meth- odological challenge. The problem has been approached from different angles, where the relation between culture of the teacher and continuous training has not been clearly discussed. In this article, which constitutes an advance in the investigation of doctoral thesis of the Faculty of Sciences of the Education of Carabobo's University, it is analyzed why the culture of the teacher needs to be recognized as a dynamic reality, dialectic and relational that affects the quality of the continuous training in Venezuelan.RésuméLa formation continue des enseignants joue un rôle essentiel dans le changement éducatif, cependant, sa concrétion prati- que représente un défi épistémologique et méthodologique. La problématique a été envisagée dès perspectives différen- tes, dans lesquelles la relation entre la culture de l'enseignant et la formation continue n'a pas encore été nettement dévoilée. Dans cet article, qui constitue une avance dans la recherche de thèse doctorale de la Faculté de Sciences de l'Éducation de l'Université de Carabobo, on

  5. Construction of a NMR permanent magnet; Construcao de um ima permanente para RMN

    Energy Technology Data Exchange (ETDEWEB)

    Colnago, Luiz Alberto; Martins Neto, Ladislau; Oste, Rene de [Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA), Sao Carlos, SP (Brazil). Nucleo de Pesquisa e Desenvolvimento de Instrumentacao Agropecuaria

    1992-12-31

    Viewing the development of the pulsed, low resolution NMR spectrometers for quantitative analysis, the electronic part of a NMR spectrometer has first been constructed, based on a 1.4 Tesla magnet of a 60 MHz Varian device, with a gap increased to 23 mm, therefore reducing the field to .66 Tesla (28 MHz for the hydrogen). For the complete construction of the spectrometer in Brazil, a permanent magnet for NMR has also been constructed 9 refs., 3 figs.

  6. del establecimiento permanente

    Directory of Open Access Journals (Sweden)

    V. Ma. Antonieta Martin Granados

    2002-01-01

    Full Text Available A pesar de que en México se han realizado adiciones a la legislación en materia civil y mercantil relacionadas con el uso de medios electrónicos como instrumentos para realizar actos jurídicos, éstas resultan insuficientes, pues nada se ha hecho en materia procesal, penal y laboral, entre otras. En este trabajo se presentan, en materia fiscal, algunas consideraciones acerca del concepto de establecimiento permanente tanto en la legislación mexicana como en el Convenio Modelo (CM de la Organización para la Cooperación y Desarrollo Económico (OCDE y se argumenta que a pesar de que la definición de la legislación mexicana es mucho más amplia que la que se encuentra en el mencionado convenio, el comercio electrónico presenta algunos retos para determinar el lugar en donde residen las partes involucradas, el lugar en donde se celebran las operaciones y se pagan o cobran, sobre todo tratándose de servicios o adquisición de bienes intangibles. Por último, se señala que en materia fiscal es necesario que las autoridades mexicanas permitan el uso de la factura electrónica

  7. A study of compositional verification based IMA integration method

    Science.gov (United States)

    Huang, Hui; Zhang, Guoquan; Xu, Wanmeng

    2018-03-01

    The rapid development of avionics systems is driving the application of integrated modular avionics (IMA) systems. But meanwhile it is improving avionics system integration, complexity of system test. Then we need simplify the method of IMA system test. The IMA system supports a module platform that runs multiple applications, and shares processing resources. Compared with federated avionics system, IMA system is difficult to isolate failure. Therefore, IMA system verification will face the critical problem is how to test shared resources of multiple application. For a simple avionics system, traditional test methods are easily realizing to test a whole system. But for a complex system, it is hard completed to totally test a huge and integrated avionics system. Then this paper provides using compositional-verification theory in IMA system test, so that reducing processes of test and improving efficiency, consequently economizing costs of IMA system integration.

  8. Achieving Kaiser Permanente quality.

    Science.gov (United States)

    McHugh, Matthew D; Aiken, Linda H; Eckenhoff, Myra E; Burns, Lawton R

    2016-01-01

    The Kaiser Permanente model of integrated health delivery is highly regarded for high-quality and efficient health care. Efforts to reproduce Kaiser's success have mostly failed. One factor that has received little attention and that could explain Kaiser's advantage is its commitment to and investment in nursing as a key component of organizational culture and patient-centered care. The aim of this study was to investigate the role of Kaiser's nursing organization in promoting quality of care. This was a cross-sectional analysis of linked secondary data from multiple sources, including a detailed survey of nurses, for 564 adult, general acute care hospitals from California, Florida, Pennsylvania, and New Jersey in 2006-2007. We used logistic regression models to examine whether patient (mortality and failure-to-rescue) and nurse (burnout, job satisfaction, and intent-to-leave) outcomes in Kaiser hospitals were better than in non-Kaiser hospitals. We then assessed whether differences in nursing explained outcomes differences between Kaiser and other hospitals. Finally, we examined whether Kaiser hospitals compared favorably with hospitals known for having excellent nurse work environments-Magnet hospitals. Patient and nurse outcomes in Kaiser hospitals were significantly better compared with non-Magnet hospitals. Kaiser hospitals had significantly better nurse work environments, staffing levels, and more nurses with bachelor's degrees. Differences in nursing explained a significant proportion of the Kaiser outcomes advantage. Kaiser hospital outcomes were comparable with Magnet hospitals, where better outcomes have been largely explained by differences in nursing. An important element in Kaiser's success is its investment in professional nursing, which may not be evident to systems seeking to achieve Kaiser's advantage. Our results suggest that a possible strategy for achieving outcomes like Kaiser may be for hospitals to consider Magnet designation, a proven and

  9. La formación permanente del profesorado en entornos virtuales de aprendizaje

    OpenAIRE

    Sonia Mª SANTOVEÑA CASAL

    2012-01-01

    La educación permanente nos permite adaptarnos a las exigencias sociales y a las demandas de la sociedad del conocimiento. En este contexto se hace imprescindible una formación permanente con apoyo de entornos virtuales de aprendizaje de calidad. El objetivo principal de esta investigación es el estudio de la calidad de los cursos virtuales destinados a la formación del profesorado desde diferentes instituciones públicas. La muestra está formada por cuatro cursos de formación permanente desti...

  10. Study of the influence of the temperature in the magnetic properties and in microstructure in the permanent magnets Pr-Fe-B-Nb-Co based obtained by hydrogen; Estudo da influencia da temperatura nas propriedades magneticas e na microestrutura nos imas permanentes a base de Pr-Fe-B-Nb-Co obtidos com hidrogenio

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Suelanny Carvalho da

    2007-07-01

    Fine magnetic powders were produced using the hydrogenation disproportionation desorption and recombination (HDDR) process. The first stage in this work involved an investigation of the effect of the Co content and range of desorption/ recombination temperatures between 800 and 900 deg C with the purpose of optimizing the HDDR treatment for Pr{sub 14}Fe{sub 80}B{sub 6} and Pr{sub 14}Fe{sub bal}Co{sub x}B{sub 6}Nb{sub 0,1} (x= 0, 4, 8, 10, 12, 16) alloys. The cast alloys were annealed at 1100 deg C for 20 hours for homogenization. The processing temperature (desorption/ recombination) affected the microstructure and magnetic properties of the bonded magnets. The alloy with low cobalt content (4 at.%) required the highest reaction temperature (880 deg C) to yield anisotropic bonded magnets. The optimum temperature for alloys with 8 at.% Co and 10 at.% Co were 840 deg C and 820 deg C, respectively. Alloys with high cobalt content (12 at.% and 16 at.%) were processed at 840 deg C. The optimum desorption temperature for achieving high anisotropy for Pr{sub 14}Fe{sub 80}B{sub 6} and Pr{sub 14}Fe{sub 79,9}B{sub 6}Nb{sub 0,1} was 820 deg C. The best remanence (862 mT) was achieved with the Pr{sub 14}Fe{sub 67,9}B{sub 6}Co{sub 12}Nb{sub 0,1} magnet, processed at 840 deg C. Each alloy required an optimum reaction temperature and exhibited a particular microstructure according to the composition. The second stage of the work involved the characterization, for each temperature, of the Pr{sub 14}Fe{sub 80}B{sub 6} HDDR powder processed using X-ray diffraction analysis. The samples of the HDDR material were studied by synchrotron radiation powder diffraction using the Rietveld method for cell refinement, phase quantification and crystallite sizes determination. Scanning electron microscopy has also been employed to reveal the morphology of the HDDR powder. (author)

  11. ) Ima Field: A Type Marginal Field-Challenges and Prospects

    International Nuclear Information System (INIS)

    Afolabi, T. J.

    2003-01-01

    The IMA Field is located in the south-eastern Niger Delta in approximately 30' of water. Discovered in 1972 by Japan Petroleum, commercial accumulation was not established until 1994 by the AMNI/Abacan Joint Venture, with the drilling of ima-3 well, which discovered the major reservoirs in the C and D sands. Recoverable Reserve of 48MMBO. Ten wells have been drilled on the IMA structure to date, with a cumulative production of 16 Million barrels of condensates.The IMA Field is a typical Niger Delta rollover anticlinal structure trending northeast southwest with a regional tilt to the northeast. The major trapping mechanism is the anticline.The sediments of IMA Field are Miocene Agbada Fm. They are deltaic deposits with high sand/shale ratio. The reservoirs are loosely compacted sandstones with porosity values ranging from 21% to 27% while permeability is generally measured in darcies.The development of IMA Field posed financial and logistical challenges since the partners had decided to fast track this process, and since neither had the resources to drill the development wells, assemble/install the crude processing and storage facilities; a mixture of debt financing and contractor financing arrangements were made.The prospects in IMA Field are to be found in early realisation of the limitations of a marginal field, particularly the management of cash flow. Workers and field development funding is financed by current production. Appraisal and exploration drilling within the same lease have required equity financing (participation)

  12. Isoflavone Malonyltransferases GmIMaT1 and GmIMaT3 Differently Modify Isoflavone Glucosides in Soybean (Glycine max under Various Stresses

    Directory of Open Access Journals (Sweden)

    Muhammad Z. Ahmad

    2017-05-01

    Full Text Available Malonylated isoflavones are the major forms of isoflavonoids in soybean plants, the genes responsible for their biosyntheses are not well understood, nor their physiological functions. Here we report a new benzylalcohol O-acetyltransferase, anthocyanin O-hydroxycinnamoyltransferase, anthranilate N-hydroxycinnamoyl/benzoyltransferase, deacetylvindoline 4-O-acetyltransferase (BAHD family isoflavone glucoside malonyltransferase GmIMaT1, and GmIMaT3, which is allelic to the previously characterized GmMT7 and GmIF7MaT. Biochemical studies showed that recombinant GmIMaT1 and GmIMaT3 enzymes used malonyl-CoA and several isoflavone 7-O-glucosides as substrates. The Km values of GmIMaT1 for glycitin, genistin, and daidzin were 13.11, 23.04, and 36.28 μM, respectively, while these of GmIMaT3 were 12.94, 26.67, and 30.12 μM, respectively. Transgenic hairy roots overexpressing both GmIMaTs had increased levels of malonyldaidzin and malonylgenistin, and contents of daidzin and glycitin increased only in GmIMaT1-overexpression lines. The increased daidzein and genistein contents were detected only in GmIMaT3-overexpression lines. Knockdown of GmIMaT1 and GmIMaT3 reduced malonyldaidzin and malonylgenistin contents, and affected other isoflavonoids differently. GmIMaT1 is primarily localized to the endoplasmic reticulum while GmIMaT3 is primarily in the cytosol. By examining their transcript changes corresponding to the altered isoflavone metabolic profiles under various environmental and hormonal stresses, we probed the possible functions of GmIMaTs. Two GmIMaTs displayed distinct tissue expression patterns and respond differently to various factors in modifying isoflavone 7-O-glucosides under various stresses.

  13. Educação permanente em enfermagem em um hospital universitário

    OpenAIRE

    Jesus,Maria Cristina Pinto de; Figueiredo,Mariangela Aparecida Gonçalves; Santos,Sueli Maria dos Reis; Amaral,Arlete Maria Moreira do; Rocha,Letícia de Oliveira; Thiollent,Michel Jean Marie

    2011-01-01

    A educação permanente enfatiza a interdisciplinaridade da equipe de saúde, focaliza a prática como fonte do conhecimento e coloca o profissional para atuar ativamente no processo educativo. Este estudo objetivou identificar demandas e expectativas, fatores que interferem na qualificação de trabalhadores de enfermagem de um hospital universitário e propor práticas de capacitação na perspectiva da educação permanente. O processo investigativo fundamentado nos princípios da pesquisa-ação foi rea...

  14. Ambient iron-mediated aeration (IMA) for water reuse.

    Science.gov (United States)

    Deng, Yang; Englehardt, James D; Abdul-Aziz, Samer; Bataille, Tristan; Cueto, Josenrique; De Leon, Omar; Wright, Mary E; Gardinali, Piero; Narayanan, Aarthi; Polar, Jose; Tomoyuki, Shibata

    2013-02-01

    Global water shortages caused by rapidly expanding population, escalating water consumption, and dwindling water reserves have rendered water reuse a strategically significant approach to meet current and future water demand. This study is the first to our knowledge to evaluate the technical feasibility of iron-mediated aeration (IMA), an innovative, potentially economical, holistic, oxidizing co-precipitation process operating at room temperature, atmospheric pressure, and neutral pH, for water reuse. In the IMA process, dissolved oxygen (O₂) was continuously activated by zero-valent iron (Fe⁰) to produce reactive oxygen species (ROS) at ambient pH, temperature, and pressure. Concurrently, iron sludge was generated as a result of iron corrosion. Bench-scale tests were conducted to study the performance of IMA for treatment of secondary effluent, natural surface water, and simulated contaminated water. The following removal efficiencies were achieved: 82.2% glyoxylic acid, ~100% formaldehyde as an oxidation product of glyoxylic acid, 94% of Ca²⁺ and associated alkalinity, 44% of chemical oxygen demand (COD), 26% of electrical conductivity (EC), 98% of di-n-butyl phthalate (DBP), 80% of 17β-estradiol (E2), 45% of total nitrogen (TN), 96% of total phosphorus (TP), 99.8% of total Cr, >90% of total Ni, 99% of color, 3.2 log removal of total coliform, and 2.4 log removal of E. Coli. Removal was attributed principally to chemical oxidation, precipitation, co-precipitation, coagulation, adsorption, and air stripping concurrently occurring during the IMA treatment. Results suggest that IMA is a promising treatment technology for water reuse. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. ProxImaL: efficient image optimization using proximal algorithms

    KAUST Repository

    Heide, Felix

    2016-07-11

    Computational photography systems are becoming increasingly diverse, while computational resources-for example on mobile platforms-are rapidly increasing. As diverse as these camera systems may be, slightly different variants of the underlying image processing tasks, such as demosaicking, deconvolution, denoising, inpainting, image fusion, and alignment, are shared between all of these systems. Formal optimization methods have recently been demonstrated to achieve state-of-the-art quality for many of these applications. Unfortunately, different combinations of natural image priors and optimization algorithms may be optimal for different problems, and implementing and testing each combination is currently a time-consuming and error-prone process. ProxImaL is a domain-specific language and compiler for image optimization problems that makes it easy to experiment with different problem formulations and algorithm choices. The language uses proximal operators as the fundamental building blocks of a variety of linear and nonlinear image formation models and cost functions, advanced image priors, and noise models. The compiler intelligently chooses the best way to translate a problem formulation and choice of optimization algorithm into an efficient solver implementation. In applications to the image processing pipeline, deconvolution in the presence of Poisson-distributed shot noise, and burst denoising, we show that a few lines of ProxImaL code can generate highly efficient solvers that achieve state-of-the-art results. We also show applications to the nonlinear and nonconvex problem of phase retrieval.

  16. The level of Ischemic Modified Albumin (IMA) as risk marker for ...

    African Journals Online (AJOL)

    Background: Recent literature reports show large interest in ischemic modified albumin (IMA) biochemical marker for detection of myocardial injury. Special attention is focused in estimation of IMA test for the diagnosis and evaluation of myocardial ischemia as well as others acute coronary syndrome in emergency patients.

  17. Agenesia en dentición permanente

    OpenAIRE

    Beltrán Morera, Jazmín

    2009-01-01

    Objetivo Determinar la frecuencia de agenesia dental en dentición permanente.Materiales y Métodos Se incluyeron 112 pacientes que acudieron al servicio de imagenología de la Facultad de Odontología, Universidad Nacional Autónoma de México, de enero a julio del 2008, mayores de 13 años, sin extracciones dentales ni síndromes genéticos, a quienes se les tomó ortopantomografía. Se registraron variablessociodemográficas y antecedentes familiares de agenesia dental. Lainformación se procesó en SPS...

  18. The applications and clinical significance of IMA, H-FABP joint CKMB in acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    Xiao-Hui Zeng

    2016-01-01

    Full Text Available Objective: To investigate the applications and clinical significance of ischemia-modified protein (IMA, heart-type fatty acid binding protein (H-FABP joint creatine kinase isoenzyme (CK-MB in acute myocardial infarction (AMI. Methods: From January 2014 to December 2014, 84 clinical materials of patients with AMI in Department of cardiology were collected, and 80 cases of normal projects were the control group. IMA was determinated with albumincobalt ion binding assay. The levels of H-FABP and CK-MB of 84 cases of AMI patients and 80 cases of normal subjects were determinated with immunoturbidimetric. The value of IMA, H-FABP and CK-MB of AMI patients were analyzed with subject-specific curve (ROC. Results: The levels of serum IMA, H-FABP and CK-MB of AMI group were significantly higher than those of the control group. Differences showed statistical significance (P < 0.05. The levels of serum IMA, H-FABP and CK-MB increased as the increase of coronary lesion vessels in patients with AMI (P < 0.05. The levels of IMA, H-FABP and CK-MB of the death group were significantly higher than those of the surviving group (P < 0.05. ROC curve analysis showed that when IMA, H-FABP and CK-MB joint detections of sensitivity, specificity, positive predictive value and negative predictive value were greater than singleindex detection (P < 0.05. Conclusions: The expression levels of IMA, H-FABP and CK-MB are closely related to the occurrence and development of disease progression in patients with AMI. IMA, H-FABP joint CK-MB detection can improve the sensitivity and specificity for early diagnosis of AMI.

  19. Digital image processing in the nuclear field with ImaWin 5.0

    International Nuclear Information System (INIS)

    Marajofsky, A.; Trafelati, A.A.; Lavagnino, C.E.

    2000-01-01

    ImaWin is a software project designed to cover a broad set of applications of Digital Image Processing in the Nuclear Field. Since 1994 the system has evolved in a complete tool that helped to face problems like densitometry calculus, quality control in pellets, deposit administration and surveillance. Neural network kernel and ImaScript scripting language are included within the package. The open and incremental development of ImaWin software has been allowing easy expansion upon a common re-engineering framework. (author)

  20. El establecimiento permanente en un contexto virtual

    Directory of Open Access Journals (Sweden)

    Andrés Mauricio Rengifo

    2002-01-01

    Full Text Available La inmediatez, la informalidad y la total irrelevancia de la localización, la distancia y los límites nacionales son ventajas innegables del comercio en Internet. Al mismo, tiempo, son características que plantean interrogantes para los Estados, quienes, conscientes de la importancia de controlar el volumen y la magnitud de las operaciones realizadas en red (al gravarlas directa o indirectamente pueden conseguir fuentes de ingreso para el mantenimiento de las estructuras y la financiación de gastos gubernamentales se cuestionan cuál debe ser el sujeto pasivo de las obligaciones tributarias en un mercado donde las empresas están deslocalizadas o aún, no existen físicamente. El presente artículo aporta a la resolución del problema tras un completo estudio del concepto de establecimiento Permanente de carácter virtual, elaborado por la Organización para la Cooperación y el Desarrollo Económico.

  1. El establecimiento permanente en un contexto virtual

    Directory of Open Access Journals (Sweden)

    Andrés Mauricio Rengifo

    2002-06-01

    Full Text Available La inmediatez, la informalidad y la total irrelevancia de la localización, la distancia y los límites nacionales son ventajas innegables del comercio en Internet. Al mismo, tiempo, son características que plantean interrogantes para los Estados, quienes, conscientes de la importancia de controlar el volumen y la magnitud de las operaciones realizadas en red (al gravarlas directa o indirectamente pueden conseguir fuentes de ingreso para el mantenimiento de las estructuras y la financiación de gastos gubernamentales se cuestionan cuál debe ser el sujeto pasivo de las obligaciones tributarias en un mercado donde las empresas están deslocalizadas o aún, no existen físicamente. El presente artículo aporta a la resolución del problema tras un completo estudio del concepto de establecimiento Permanente de carácter virtual, elaborado por la Organización para la Cooperación y el Desarrollo Económico.

  2. Permanent magnet generator for direct drive for vertical axis turbine; Gerador de imas permanentes de acionamento direto para turbina de eixo vertical

    Energy Technology Data Exchange (ETDEWEB)

    Eriksson, Sandra; Semberg, Tobias; Bernhoff, Hans; Leijon, Mats [Universidade de Uppsala (Sweden)

    2011-10-15

    The design and construction of a synchronous generator specifically designed to be directly driven by a vertical axis wind turbine are described here. The generator is unique in many respects: it has several poles, large diameter, relatively high voltage, low speed and high overload capability. Among other important aspects, the article discusses the differences between the simulated geometry and the obtained.

  3. Educación permanente y continua en una perspectiva de integridad del ser

    Directory of Open Access Journals (Sweden)

    Izabel Cristina Feijó de Andrade

    2014-12-01

    Full Text Available Este artículo buscó discutir las articulaciones y distinciones entre los conceptos de educación permanente y educación continua de modo que favorezca la perspectiva de integridad del ser, vínculo que requiere saberes hasta entonces poco privilegiados en las Universidades y que demandan el rescate de dimensiones basadas en la experiencia, la didáctica y la existencia del educador, tanto individual, comportamental, cultural, social y espiritual. Consideramos que las nociones de educación permanente y educación continua poseen elementos entrelazables que nos permiten desarrollar la capacidad de reaccionar críticamente por medio de una relación autoformativa. Las revisiones teóricas implementadas permitieron algunas consideraciones sobre los procesos formativos actuales y las prácticas de profesores rumbo a una Educación para la Integridad. Concluimos provisoriamente que las aproximaciones y distinciones entre EP y EC pueden proporcionar a los profesores la toma de conciencia de su vinculación todo/parte y del sentido de la vida.

  4. The Design and Implementation of a Prototype Web-Portal for the Integrated Mobile Alerting System (IMAS)

    National Research Council Canada - National Science Library

    Le, Phong D; Hsu, Michael

    2006-01-01

    .... It demonstrates that a web-portal written in PHP script supported by a relational database is a good configuration for IMAS. Additionally, a proof of concept system that converts messages into disseminated mobile alerts is presented. This thesis marks the founding steps in developing the IMAS.

  5. Properties and simulation of α-permanental random fields

    DEFF Research Database (Denmark)

    Møller, Jesper; Rubak, Ege Holger

    An α-permanental random field is briefly speaking a model for a collection of random variables with positive associations, where α is a positive number and the probability generating function is given in terms of a covariance or more general function so that density and moment expressions are given...... by certain α-permanents. Though such models possess many appealing probabilistic properties, many statisticians seem unaware of  α-permanental random fields and their potential applications. The purpose of this paper is first to summarize useful probabilistic results using the simplest possible setting......, and second to study stochastic constructions and simulation techniques, which should provide a useful basis for discussing the statistical aspects in future work. The paper also discusses some examples of  α-permanental random fields....

  6. Ahvid õppisid kahel jalal käima puu otsas / Alo Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Alo

    2007-01-01

    Vt. ka Postimees : na russkom jazõke 15. juuni, lk. 9. Suurbritannia Birminghami ülikooli teadlased eesotsas Susannah Thorpe'iga väidavad ajakirjas Science avaldatud töös, et ahvid õppisid kahel jalal käima puu otsas turnides

  7. Transformation of Inhibitor of Meristem Activity (IMA Gene into Jatropha curcas L.

    Directory of Open Access Journals (Sweden)

    Asri Pirade Paserang

    2015-09-01

    Full Text Available Jatropha is one of the many biodiesel plants developed in tropical countries. Efforts to increase its productivity can be done using various methods of breeding. One of the breeding methods is the introduction of genes into the Jatropha plant. The aim of this study is to assess the success of genetic transformation using the Inhibitor of Meristem Activity (IMA gene in Jatropha curcas. The research procedures included inoculation of explants with Agrobacterium tumefaciens, callus induction, screening test of selection media, regeneration, and gene expression analysis using Polymerase Chain Reaction (PCR. IMA is one of the genes that controls flowering genes and ovule development. It was first isolated from tomato plants and has been successfully overexpressed in these plants using the Cauliflower Mosaic Virus (CaMV 35S promoter. In this experiment, plant transformation was performed on J. curcas as the target. Explant callus formation in both the control and treated samples was good, but shoot formation decreased dramatically in the treated explants. PCR analysis indicated that IMA genes can be inserted into J. curcas with the size of the IMA gene is 500 bp.

  8. Kuperjanovlased lükkasid prügikoristuskampaania käima / Elina Kononenko

    Index Scriptorium Estoniae

    Kononenko, Elina, 1981-

    2008-01-01

    Eelmise nädala neljapäeval lükkasid ligi 160 Kuperjanovi üksik-jalaväepataljoni sõdurit Võrumaal käima kodanikualgatusliku kampaania "Teeme ära 2008" ning kaardistasid illegaalseid prügimägesid viies vallas

  9. On the parameter estimation of first order IMA model corrupted with ...

    African Journals Online (AJOL)

    In this paper, we showed how the autocovariance functions can be used to estimate the true parameters of IMA(1) models corrupted with white noise . We performed simulation studies to demonstrate our findings. The simulation studies showed that under the presence of errors in not more than 30% of total data points, our ...

  10. Pure NOTES rectosigmoid resection: transgastric endoscopic IMA dissection and transanal rectal mobilization in animal models.

    Science.gov (United States)

    Park, Sun Jin; Lee, Kil Yeon; Choi, Sung Il; Kang, Byung Mo; Huh, Chang; Choi, Dong Hyun; Lee, Chang Kyun

    2013-07-01

    We report a pure natural orifice translumenal endoscopic surgery (NOTES(®); American Society for Gastrointestinal Endoscopy [Oak Brook, IL] and the Society of American Gastrointestinal and Endoscopic Surgeons [Los Angeles, CA]) rectosigmoidectomy in animal models using transgastric endoscopic inferior mesenteric artery (IMA) dissection and transanal rectal mobilization. Ten live animals (2 pigs weighing 35-40 kg each and 8 dogs weighing 25-30 kg each) were used. A gastrotomy was made using a needle-knife puncture and the balloon dilatation technique or following the creation of a submucosal tunnel. A circular stapler shaft was transanally inserted up to the sigmoid colon for spatial orientation and traction of the mesocolon. The IMA was endoscopically dissected using a Coagrasper™ (Olympus, Tokyo, Japan) and then clipped. Endoscopic division of the sigmoid mesocolon was conducted laterally toward the marginal artery. Transanal full-thickness circumferential rectal and mesorectal dissections were performed, and a colorectal anastomosis was performed using a circular stapler with a single stapling technique. During the transanal approach, the gastrotomy was closed using four endoscopic clips. Endoscopic dissection of the IMA was successful in all cases, but minor bleedings occurred in 3 cases. The mean time from dissection and clipping to division of the IMA was 36.7 minutes (range, 25-45 minutes). The mean operation time was 180.5 minutes (range, 145-210 minutes). There were no intraoperative complications or hemodynamic instability. The mean length of the resected specimen was 11.2 cm (range, 9-17 cm). A pure NOTES approach to rectosigmoid resection using transgastric endoscopic IMA dissection is technically feasible in animal models.

  11. Educação Permanente em Saúde no Brasil: educação ou gerenciamento permanente?

    Directory of Open Access Journals (Sweden)

    Cristiane Lopes Simão Lemos

    2016-03-01

    Full Text Available Resumo O objetivo do estudo foi analisar a concepção e os fundamentos da Educação Permanente em Saúde (EPS constante da Política Nacional de Educação Permanente em Saúde (PNEPS no Brasil. A metodologia baseou-se na análise de documentos do Ministério da Saúde e de artigos científicos relacionados. Constatou-se que a concepção da EPS na PNEPS transcende um significado pedagógico, respondendo a um processo de reestruturação dos serviços diante das novas demandas do modelo. Justamente no momento em que o trabalho se encontra cada vez mais instável e precarizado, o Ministério da Saúde apresenta um discurso sobre uma gestão inovadora, dando centralidade à questão da EPS. A ideia não é de educação permanente, mas de gerenciamento permanente. Ao contrário de um instrumento de transformação radical, a EPS converte-se em uma ideologia que seduz pela sua aparência de novidade pedagógica.

  12. Le tecnologie mobili dell’apprendimento permanente, il progetto MOTILL

    Directory of Open Access Journals (Sweden)

    Marco Arrigo

    2013-03-01

    Full Text Available In questo articolo vengono presentati alcuni dei risultati del progetto MOTILL. MOTILL, ovvero «Le Tecnologie Mobili nell’apprendimento permanente: buone pratiche», è un progetto finanziato dalla Comunità Europea, nell’ambito del National Lifelong Learning Strategies (NLLS. Il progetto, durato un anno e terminato a Marzo 2010, si è focalizzato sull’uso delle tecnologie mobili in contesti di lifelong learning (LLL. L’articolo sarà dedicato a una breve introduzione del progetto, dei suoi obiettivi e delle azioni portate avanti, e a un rapido riassunto dei principali risultati ottenuti, i quali sono stati resi disponibili online alla comunità scientifica e diffusi ai policy makers impegnati nei programmi di apprendimento permanente.

  13. Intersection local times, loop soups and permanental Wick powers

    CERN Document Server

    Jan, Yves Le; Rosen, Jay

    2017-01-01

    Several stochastic processes related to transient Lévy processes with potential densities u(x,y)=u(y-x), that need not be symmetric nor bounded on the diagonal, are defined and studied. They are real valued processes on a space of measures \\mathcal{V} endowed with a metric d. Sufficient conditions are obtained for the continuity of these processes on (\\mathcal{V},d). The processes include n-fold self-intersection local times of transient Lévy processes and permanental chaoses, which are `loop soup n-fold self-intersection local times' constructed from the loop soup of the Lévy process. Loop soups are also used to define permanental Wick powers, which generalizes standard Wick powers, a class of n-th order Gaussian chaoses. Dynkin type isomorphism theorems are obtained that relate the various processes. Poisson chaos processes are defined and permanental Wick powers are shown to have a Poisson chaos decomposition. Additional properties of Poisson chaos processes are studied and a martingale extension is obt...

  14. ImaSim, a software tool for basic education of medical x-ray imaging in radiotherapy and radiology

    Science.gov (United States)

    Landry, Guillaume; deBlois, François; Verhaegen, Frank

    2013-11-01

    Introduction: X-ray imaging is an important part of medicine and plays a crucial role in radiotherapy. Education in this field is mostly limited to textbook teaching due to equipment restrictions. A novel simulation tool, ImaSim, for teaching the fundamentals of the x-ray imaging process based on ray-tracing is presented in this work. ImaSim is used interactively via a graphical user interface (GUI). Materials and methods: The software package covers the main x-ray based medical modalities: planar kilo voltage (kV), planar (portal) mega voltage (MV), fan beam computed tomography (CT) and cone beam CT (CBCT) imaging. The user can modify the photon source, object to be imaged and imaging setup with three-dimensional editors. Objects are currently obtained by combining blocks with variable shapes. The imaging of three-dimensional voxelized geometries is currently not implemented, but can be added in a later release. The program follows a ray-tracing approach, ignoring photon scatter in its current implementation. Simulations of a phantom CT scan were generated in ImaSim and were compared to measured data in terms of CT number accuracy. Spatial variations in the photon fluence and mean energy from an x-ray tube caused by the heel effect were estimated from ImaSim and Monte Carlo simulations and compared. Results: In this paper we describe ImaSim and provide two examples of its capabilities. CT numbers were found to agree within 36 Hounsfield Units (HU) for bone, which corresponds to a 2% attenuation coefficient difference. ImaSim reproduced the heel effect reasonably well when compared to Monte Carlo simulations. Discussion: An x-ray imaging simulation tool is made available for teaching and research purposes. ImaSim provides a means to facilitate the teaching of medical x-ray imaging.

  15. Two designs for image digital processing applications in the nuclear area using ImaWin

    International Nuclear Information System (INIS)

    Lavagnino, Carlos E.; Marajofsky, Adolfo

    1999-01-01

    In this work two designs of image processing systems of low cost for the nuclear area are presented. They have the advantage of the adaptability given by the ImaWin software and the connection with Internet, applied to digitalisation in research and development fields. The first design is the development of a digitalisation system for inspection and study of fuel plate radiographs for test reactors, while the second one describes the specification and design of an intelligent system of intrusion signals continuous inspection and administrative control of fissile material deposits. (author)

  16. Biopoder e UPPs: alteridade na experiência do policiamento permanente em comunidades cariocas

    Directory of Open Access Journals (Sweden)

    Thiago Benedito Livramento Melicio

    2012-12-01

    Full Text Available O artigo visa refletir sobre a experiência do efetivo policial permanente em dois conjuntos de comunidades cariocas, inserido no escopo das Unidades de Polícia Pacificadora (UPP. Foram realizados dois estudos exploratórios, em agosto e dezembro de 2010. Na esteira do conceito foucaultiano de biopoder, discute-se a UPP como rede de relações de poder que a compõe e a legitima, pensando-se o local em que se instala, a política de Estado a que responde, os atores com que opera e as produções históricas das relações entre Estado e territórios populares. O campo de análise constitui-se, assim, nas práticas e saberes localizados no cotidiano e nos efeitos produzidos com a presença do policial na paisagem da favela. Se novas regras são trazidas com as UPPs, novas identificações são mobilizadas e as modulações de conjunto abrem lacunas, o governo de si não se produz sozinho, mas combina-se com diversidades na gestão da vida.

  17. Flexibilidad laboral: ¿fin del trabajo permanente?

    Directory of Open Access Journals (Sweden)

    Carmen Añez Hernández

    2016-05-01

    Full Text Available Los trabajos transitorios o atípicos, siguen posicionándose y funcionando trastocando la protección del sistema de regulación y protección del trabajo permanente. De ahí, la importancia de reflexionar teóricamente sobre el tema. Para su desarrollo se plantean los siguientes objetivos: demostrar que la flexibilización laboral ha incidido en la ruptura de las relaciones laborales, caracterizar como la subcontratación laboral encubre dichas relaciones, analizar el despido laboral y sus consecuencias en los trabajadores. El artículo se desarrolló teóricamente, especialmente tomando como referencia autores como: Bravo (2010, Quintero (2010, González (2012 De La Garza (2007, Ugarte (2007, entre otros, lo cual permitió analizar la temática abordada. Los resultados reflejan que dicha estrategia está impulsando la agudización de las condiciones precarias de los derechos laborales, con lo cual se está ante un capitalismo irracional, que tiene como propósito que los trabajadores sufraguen los efectos de las pretensiones de los capitalistas por conseguir mayores tasas de ganancia y niveles más altos de productividad. En consecuencia, la flexibilización de las relaciones laborales está destinada a ocultar los derechos de los trabajadores, agudizar el despido laboral, y propiciar el fin de un trabajo permanente.

  18. Development of a power train for the hybrid automobile - the Civic IMA

    Energy Technology Data Exchange (ETDEWEB)

    Matsuki, Masato; Sato, Toshiyuki; Wakashiro, Teruo; Kaku, Toshiaki; Kamiyama, Toshihiro; Kanda, Masahiro [Tochigi R and D Center (Japan); Brachmann, T. [Tochigi Offenbach R und D Center (Germany)

    2003-07-01

    The Civic Hybrid was developed as a compact passenger hybrid car that achieves both low fuel consumption and cleaner operation from the viewpoints of preserving the global environment and conserving resources. The engine has been improved for Hybrid applications, which were added to the base i-DSI, 4-cylinder, 1.3-liter SOHC, 2-ignition plugs/cylinder engine mounted in the Honda 'Jazz'. In addition, the cylinder idling system has been adopted to increase the regenerated energy during deceleration. The hybrid system is based on the Honda IMA system, and the maximum regenerative torque has been increased by approximately 30% by improving the magnetic circuits of an ultra-thin DC brushless motor and adopting a new rotor manufacturing method. Fuel economy is improved by a new hybrid power train, thus achieving low fuel consumption of 4.9 1/100 km in the European UDC+EUCD combined mode by at the same time meeting EURO IV standards. The power control unit, which is the IMA system control unit, was downsized and located behind the rear seat, thus ensuring comparable trunk capacity to the base vehicle of the Civic 4-Door. Hybrid vehicles have a lot to offer. This paper introduces evolutionary developments of Hybrid vehicles within the Honda Motor Company. (orig.)

  19. Tallinna-Tartu liinil jääb käima üks rong / Hindrek Riikoja

    Index Scriptorium Estoniae

    Riikoja, Hindrek

    2001-01-01

    Teede- ja sideminister Toivo Jürgenson ning Edelaraudtee juhatuse esimees Henn Ruubel allkirjastasid reisijateveo lepingu, mille järgi jääb Tallinna-Tartu liinil käima üks rong päevas. Uued bussiliinid

  20. Image microarrays derived from tissue microarrays (IMA-TMA: New resource for computer-aided diagnostic algorithm development

    Directory of Open Access Journals (Sweden)

    Jennifer A Hipp

    2012-01-01

    Full Text Available Background: Conventional tissue microarrays (TMAs consist of cores of tissue inserted into a recipient paraffin block such that a tissue section on a single glass slide can contain numerous patient samples in a spatially structured pattern. Scanning TMAs into digital slides for subsequent analysis by computer-aided diagnostic (CAD algorithms all offers the possibility of evaluating candidate algorithms against a near-complete repertoire of variable disease morphologies. This parallel interrogation approach simplifies the evaluation, validation, and comparison of such candidate algorithms. A recently developed digital tool, digital core (dCORE, and image microarray maker (iMAM enables the capture of uniformly sized and resolution-matched images, with these representing key morphologic features and fields of view, aggregated into a single monolithic digital image file in an array format, which we define as an image microarray (IMA. We further define the TMA-IMA construct as IMA-based images derived from whole slide images of TMAs themselves. Methods: Here we describe the first combined use of the previously described dCORE and iMAM tools, toward the goal of generating a higher-order image construct, with multiple TMA cores from multiple distinct conventional TMAs assembled as a single digital image montage. This image construct served as the basis of the carrying out of a massively parallel image analysis exercise, based on the use of the previously described spatially invariant vector quantization (SIVQ algorithm. Results: Multicase, multifield TMA-IMAs of follicular lymphoma and follicular hyperplasia were separately rendered, using the aforementioned tools. Each of these two IMAs contained a distinct spectrum of morphologic heterogeneity with respect to both tingible body macrophage (TBM appearance and apoptotic body morphology. SIVQ-based pattern matching, with ring vectors selected to screen for either tingible body macrophages or apoptotic

  1. MENADŽMENT LJUDSKIH POTENCIJALA U VELIKIM HRVATSKIM PODUZEĆIMA

    OpenAIRE

    Pološki Vokić, Nina

    2004-01-01

    Budući da je menadžment ljudskih potencijala osnovica za ostvarivanje konkurentskih prednosti uz pomoć ljudi i zato što je značajno povezan s uspješnošću organizacija, u radu se nastojala istražiti važnost i razvijenost te funkcije u velikim hrvatskim poduzećima. U radu su postavljene dvije hipoteze: (1) da hrvatska poduzeća nemaju razvijenu praksu MLJP (menadžment ljudskih potencijala) i (2) da postoje aktivnosti MLJP, provođenje kojih je značajno povezano s općom uspješnošću poduzeća; obje ...

  2. The Design and Implementation of a Prototype Web-Portal for the Integrated Mobile Alerting System (IMAS)

    Science.gov (United States)

    2006-06-01

    employed in small to medium sized applications. Its cost and ease of management allow beginners to easily develop their own databases within...that it can run stored procedures written with various programming languages such as C/C++, Perl, Java, and Python . Unlike MySQL, PostgreSQL fully...server combination utilizes the LAMP configuration. LAMP stands 38 for Linux, Apache, MySQL, and Perl/PHP/ Python . IMAS utilizes the LAMP

  3. Magneto-static Modeling from Sunrise/IMaX: Application to an Active Region Observed with Sunrise II

    Energy Technology Data Exchange (ETDEWEB)

    Wiegelmann, T.; Solanki, S. K.; Barthol, P.; Gandorfer, A.; Gizon, L.; Hirzberger, J.; Riethmüller, T. L.; Noort, M. van [Max-Planck-Institut für Sonnensystemforschung, Justus-von-Liebig-Weg 3, D-37077 Göttingen (Germany); Neukirch, T. [School of Mathematics and Statistics, University of St. Andrews, St. Andrews KY16 9SS (United Kingdom); Nickeler, D. H. [Astronomical Institute, AV CR, Fricova 298, 25165 Ondrejov (Czech Republic); Rodríguez, J. Blanco [Grupo de Astronomía y Ciencias del Espacio, Universidad de Valencia, E-46980 Paterna, Valencia (Spain); Iniesta, J. C. Del Toro; Suárez, D. Orozco [Instituto de Astrofísica de Andalucía (CSIC), Apartado de Correos 3004, E-18080 Granada (Spain); Schmidt, W. [Kiepenheuer-Institut für Sonnenphysik, Schöneckstr. 6, D-79104 Freiburg (Germany); Pillet, V. Martínez [National Solar Observatory, 3665 Discovery Drive, Boulder, CO 80303 (United States); Knölker, M., E-mail: wiegelmann@mps.mpg.de [High Altitude Observatory, National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307-3000 (United States)

    2017-03-01

    Magneto-static models may overcome some of the issues facing force-free magnetic field extrapolations. So far they have seen limited use and have faced problems when applied to quiet-Sun data. Here we present a first application to an active region. We use solar vector magnetic field measurements gathered by the IMaX polarimeter during the flight of the Sunrise balloon-borne solar observatory in 2013 June as boundary conditions for a magneto-static model of the higher solar atmosphere above an active region. The IMaX data are embedded in active region vector magnetograms observed with SDO /HMI. This work continues our magneto-static extrapolation approach, which was applied earlier to a quiet-Sun region observed with Sunrise I. In an active region the signal-to-noise-ratio in the measured Stokes parameters is considerably higher than in the quiet-Sun and consequently the IMaX measurements of the horizontal photospheric magnetic field allow us to specify the free parameters of the model in a special class of linear magneto-static equilibria. The high spatial resolution of IMaX (110–130 km, pixel size 40 km) enables us to model the non-force-free layer between the photosphere and the mid-chromosphere vertically by about 50 grid points. In our approach we can incorporate some aspects of the mixed beta layer of photosphere and chromosphere, e.g., taking a finite Lorentz force into account, which was not possible with lower-resolution photospheric measurements in the past. The linear model does not, however, permit us to model intrinsic nonlinear structures like strongly localized electric currents.

  4. ImaEdge - a platform for quantitative analysis of the spatiotemporal dynamics of cortical proteins during cell polarization.

    Science.gov (United States)

    Zhang, Zhen; Lim, Yen Wei; Zhao, Peng; Kanchanawong, Pakorn; Motegi, Fumio

    2017-12-15

    Cell polarity involves the compartmentalization of the cell cortex. The establishment of cortical compartments arises from the spatial bias in the activity and concentration of cortical proteins. The mechanistic dissection of cell polarity requires the accurate detection of dynamic changes in cortical proteins, but the fluctuations of cell shape and the inhomogeneous distributions of cortical proteins greatly complicate the quantitative extraction of their global and local changes during cell polarization. To address these problems, we introduce an open-source software package, ImaEdge, which automates the segmentation of the cortex from time-lapse movies, and enables quantitative extraction of cortical protein intensities. We demonstrate that ImaEdge enables efficient and rigorous analysis of the dynamic evolution of cortical PAR proteins during Caenorhabditis elegans embryogenesis. It is also capable of accurate tracking of varying levels of transgene expression and discontinuous signals of the actomyosin cytoskeleton during multiple rounds of cell division. ImaEdge provides a unique resource for quantitative studies of cortical polarization, with the potential for application to many types of polarized cells.This article has an associated First Person interview with the first authors of the paper. © 2017. Published by The Company of Biologists Ltd.

  5. La incapacidad permanente en una empresa pública en el periodo 1995-2009 Permanent incapacity in a public company from 1995-2009

    Directory of Open Access Journals (Sweden)

    José Carlos Marchena Aparicio

    2011-09-01

    Full Text Available Objetivos: La cuantificación de las relaciones entre salud, medio laboral y capacidad para el trabajo nos permite descifrar aspectos importantes de la incapacidad permanente. Este trabajo tiene como objetivo describir las características de la población trabajadora de la Diputación Provincial de Cádiz a la que se le concedió una incapacidad permanente en el periodo 1995-2009. Métodos: Se llevó a cabo un estudio descriptivo retrospectivo sobre el total de trabajadores/as con incapacidad permanente en el periodo descrito que considera las siguientes variables: sexo, edad, antigüedad, tipo de ocupación, causa de la incapacidad permanente, días de incapacidad temporal y número de incapacidades temporales concedidas en los 5 años previos, recogidas a través de archivos documentales. Resultados: El número de incapacidades permanentes concedidas ascendió a 192. Un 53,1% fueron mujeres; funcionarios el 59,9%; la edad de concesión fue de 54,06 años de media con 24,98 años de antigüedad en la empresa; el tipo de trabajo en el que más incapacidad permanente se concedieron es el manual, 44,8%; El tipo de patología más frecuente de incapacidad permanente fueron las enfermedades músculo-esqueléticas (29,7%, neoplasias (23,4% y trastornos mentales (18,8%, asociándose significativamente dicha variable con el sexo (p=0,006, el tipo de trabajo desempeñado (p=0,007, la edad de concesión (pObjectives: The quantifying relationship between health, working environment and work capacity allows us to unravel important aspects of permanent incapacity (PI. One of the objectives of this study is to describe working population characteristics of the Provincial Council of Cadiz who were granted permanent incapacity from 1995 to 2009. Method: A retrospective descriptive study was carried out amongst all the workers with PI in the period described with the following variables taken into account: gender, age, time working for the company, type of

  6. Driving and control strategies in alternative current machines of permanent magnet with non-sinusoidal flux; Estrategias de acionamento e controle em maquinas CA de ima permanente com fluxo nao senoidal

    Energy Technology Data Exchange (ETDEWEB)

    Monteiro, Jose Roberto Boffino de Almeida

    1997-07-01

    The aim of this work is to study and analyze the torque performance of brush less machines with non-sinusoidal distributed magnetic fluxes. The machine type considered is a surface mount permanent magnet brush less machine. Three mathematical models for the machine are considered: the per stator phase, the vectorial and the linear second order speed-voltage models. Machines with different stator windings are compared including the permanent magnet synchronous machines with sinusoidal distributed stator windings. The torque outputs of these machines are obtained considering two kinds of open loop driving systems: one with a six-pulse waveform and other with a sinusoidal waveform. Finally, a vectorial control is proposed for the non-sinusoidal machines. The torque ripple as well the overall performance of non-sinusoidal machines with vectorial control is compared to that of sinusoidal machines. (author)

  7. Study of the influence of zirconium and gallium on the magnetic properties and microstructures of praseodymium-based permanent magnets; Estudo da influencia do zirconio e galio nas propriedades magneticas e na microestrutura dos imas permanentes a base de praseodimio

    Energy Technology Data Exchange (ETDEWEB)

    Fusco, Alexandre Giardini

    2006-07-01

    In this work was studied the influence of the addition of 0.5 at. % of zirconium and gallium on praseodymium-based HD sintered magnets obtained using a mixture of alloys. The alloys used in this study were: Pr{sub 12.6}Fe{sub 68.3}Co{sub 11.6}B{sub 6}Zr{sub 0.5}Ga{sub 1}, Pr{sub 16}Fe{sub 75.5}B{sub 8}Zr{sub 0.5}, Pr{sub 13}Fe{sub 80.5}B{sub 6}Zr{sub 0.5}. The investigation started by measuring the magnetic properties and observing the microstructure of the magnets. After that, the magnets were annealed at 1000 deg C for 2 hours followed by rapid cooling, in a total of 10 hours. This heat treatment was followed by 5 hours at the same temperature up to a total of 35 hours. Changes in the microstructure were compared to the change in the magnetic properties aiming at a proper understanding of the role of each added element in relation to the magnetically hard phase (phase {phi}). It has been shown that gallium and zirconium act as grain refiners of the matrix phase {phi}. Gallium acts in the grain and favoring of the shape stability and improvement of the magnetic properties. For the Pr{sub 14.3}Fe{sub 71.9}Co{sub 5.8}B{sub 7}Zr{sub 0.5}Ga{sub 0.5} sintered magnet the evolution of the magnetic properties after 15 hours heat treatment was: remanence from (1.25{+-}0.02) T to (1.30{+-}0.02) T, intrinsic coercivity from (1.11{+-}0.02) T to (0.87{+-}0.02) T, squareness factor from (0.68{+-}0.02) to (0.82{+-}0.02) and energy product from (285{+-}5) kJ/m{sup 3} to (317{+-}5) kJ/m{sup 3}. Zirconium has two effects on the sintered magnets. Firstly, avoiding random grain growth and enhancing anisotropy. However, by concentrating on the grain boundaries, yield reverse domains and is detrimental to the intrinsic coercivity. For the sintered Pr{sub 14.5}Fe{sub 78}B{sub 7}Zr{sub 0.5} magnet the evolution of the magnetic properties achieved after a heat treatment of 15 hours was: remanence from (1.19{+-}0.02) T to (1.25{+-}0.02) T, coercivity from (0.74{+-}0.02) T to (0.94{+-}0.02) T, squareness factor from (0.88{+-}0.02) to (0,85{+-}0.02) and energy product from (258{+-}5) kJ/m{sup 3} to (291{+-}5) kJ/m{sup 3}. For the Pr{sub 16}Fe{sub 75.5}B{sub 8}Zr{sub 0.5} sintered magnet the evolution of magnetic properties after 20 hours heat treatment was: remanence from (1.17{+-}0,02) T to (1.24{+-}0.02) T, coercivity from (0.90{+-}0,02) T to (1.22{+-}0.02) T, squareness factor from (0,93{+-}0,02) to (0.66{+-}0.02) and energy product from (258{+-}5) kJ/m{sup 3} to (291{+-}5) kJ/m{sup 3}. (author)

  8. Políticas y prácticas en la formación permanente del profesorado en TIC en Cataluña

    OpenAIRE

    Adriana Ornellas; Joan\\u2010Anton Sánchez; Leticia Fraga Colman; Laura Domingo

    2015-01-01

    En este artículo presentamos los resultados que emergen de una de las dimensiones investigadas en el proyecto “Políticas y prácticas en torno a las TIC en la enseñanza obligatoria: Implicaciones para la innovación y la mejora” (Ministerio de Ciencia e Innovación. SEJ2007-­‐67562). Nos centramos aquí en uno de los factores determinantes del éxito o fracaso de las políticas destinadas a transformar las prácticas educativas a partir de la integración de las TIC: la formación inicial y permanente...

  9. Educação Permanente em Saúde e Manoel de Barros: uma Aproximação Desformadora

    Directory of Open Access Journals (Sweden)

    Eluana Borges Leitão de Figueiredo

    Full Text Available RESUMO Trata-se de uma reflexão que promove diálogo entre pressupostos da Educação Permanente em Saúde (EPS e proposições desformadoras do poeta Manoel de Barros, com o objetivo de contribuir para a transvisão da formação e do trabalho em saúde. Optou-se por desvelar tal aproximação com base nos versos do poema “As lições de RQ”, que funcionaram como plataforma para os saltos reflexivos. A discussão encontrou respaldo principal em Paulo Freire e Adolfo Sanchez Vázquez, uma vez que caminhou na perspectiva de uma práxis revolucionária, transformadora e libertadora.

  10. Políticas y prácticas en la formación permanente del profesorado en TIC en Cataluña

    Directory of Open Access Journals (Sweden)

    Adriana Ornellas

    2015-01-01

    Full Text Available En este artículo presentamos los resultados que emergen de una de las dimensiones investigadas en el proyecto “Políticas y prácticas en torno a las TIC en la enseñanza obligatoria: Implicaciones para la innovación y la mejora” (Ministerio de Ciencia e Innovación. SEJ2007-­‐67562. Nos centramos aquí en uno de los factores determinantes del éxito o fracaso de las políticas destinadas a transformar las prácticas educativas a partir de la integración de las TIC: la formación inicial y permanente del profesorado.

  11. Genito-Urinary Function and Quality of Life after Elective Totally Laparoscopic Sigmoidectomy after at Least One Episode of Complicated Diverticular Disease According to Two Different Vascular Approaches: the IMA Low Ligation or the IMA Preservation.

    Science.gov (United States)

    Mari, Giulio; Crippa, Jacopo; Costanzi, Andrea; Mazzola, Michele; Magistro, Carmelo; Ferrari, Giovanni; Maggioni, Dario

    2017-01-01

    The arterial ligation during elective laparoscopic sigmoidectomy for diverticular disease can affect genito-urinary function injuring the superior hypogastric plexus, and can weaken the distal colonic stump arterial perfusion. Ligation of the inferior mesenteric artery distal to the left colic artery or the complete preservation of the inferior mesenteric artery can therefore be compared in terms of preservation of the descending sympathetic fibres running along the aorta to the rectum resulting in a different post operative genito urinary function. From January 2015 to March 2016, 66 patients underwent elective laparoscopic sigmoidectomy for diverticular disease among two enrolling hospitals. In one centre 35 patients underwent laparoscopic sigmoidectomy with the ligation of the inferior mesenteric artery distal to the left colic artery (low ligation). In the other centre 31 patient were operated on the same procedure with complete inferior mesenteric artery preservation (IMA preservation). There was no difference in terms of major complication occurred, first passage of stool and length of hospital stay between the two groups. Time of surgery was significantly shorter in LL group compared to IMA preserving group and intra operative blood loss was significantly lower in the LL group. There were no differences in the genito urinary function between the two group pre operatively, at 1 and 9 months post operatively. Genito urinary function did not significantly change across surgery in each groups. The low ligation and the IMA preserving vascular approach are safe end feasible techniques in elective laparoscopic sigmoidectomy for diverticular disease. They both prevent from genito-urinary post-operative disfunction and allow good post operative quality of life. The low ligation approach is related to shorter operative time and slower intra operative blood loss. Celsius.

  12. Um teste direto da teoria de renda permanente: o caso brasileiro

    Directory of Open Access Journals (Sweden)

    Fábio Augusto Reis Gomes

    2012-01-01

    Full Text Available O presente artigo busca averiguar se a teoria da renda permanente (TRP é capaz de explicar a evolução do consumo no Brasil através de um teste direto com base em revisões de consumo induzidas por inovações na renda. De acordo com a TRP, o consumo reage às mudanças na renda na medida em que a renda corrente contem informação sobre a renda permanente. Para mensurar esta relação, foi estimado um modelo ARIMA (p,1,q para a renda corrente e, como resultado, foi possível verificar se as revisões de consumo e renda permanente se assemelham. Por fim, a TRP foi rejeitada.

  13. Las enfermedades neoplásicas como causa de la incapacidad permanente

    OpenAIRE

    Ares Camerino, A.; Sainz Vera, B.; Marchena Aparicio, J.C.; Soto Pino, M.L.

    2008-01-01

    El cáncer es la primera causa de mortalidad en hombres y la segunda en mujeres, tras las enfermedades cardiovasculares. Desde el punto de vista económico, los costes atribuibles a las enfermedades neoplásicas son principalmente indirectos (pérdida de productividad asociada a la mortalidad o a la incapacidad permanente). Analizando las incapacidades permanentes producidas en la Diputación Provincial de Cádiz en el período 1990-2005, que fueron un total de 208, se concluye, por orden de frecuen...

  14. Investing in Obesity Treatment: Kaiser Permanente's Approach to Chronic Disease Management.

    Science.gov (United States)

    Tsai, Adam G; Histon, Trina; Donahoo, W Troy; Hashmi, Shahid; Murali, Sameer; Latare, Peggy; Oliver, Lajune; Slovis, Jennifer; Grall, Sarah; Fisher, David; Solomon, Loel

    2016-09-01

    Kaiser Permanente, an integrated health care delivery system in the USA, takes a "whole systems" approach to the chronic disease of obesity that begins with efforts to prevent it by modifying the environment in communities and schools. Aggressive case-finding and substantial investment in intensive lifestyle modification programs target individuals at high risk of diabetes and other weight-related conditions. Kaiser Permanente regions are increasingly standardizing their approach when patients with obesity require treatment intensification using medically supervised diets, prescription medication to treat obesity, or weight loss surgery.

  15. Tu nos aposte protege

    DEFF Research Database (Denmark)

    Frederiksen, Britta Olrik

    2007-01-01

    Aspirationen af p, t og k i dansk er stedmoderligt behandlet af den gren af den historiske sprogforskning der bygger på skriftligt kildemateriale. Skrivemåden tu nos aposte protege for tu nos ab hoste protege 'bekyt du os mod fjenden' i en tilskrift fra anden halvdel af 1300-tallet i...

  16. UPRAVLJANJE ODNOSIMA S POTROŠAČIMA U FUNKCIJI ZADRŽAVANJA POTROŠAČA

    Directory of Open Access Journals (Sweden)

    Branimir Dukić

    2015-12-01

    Full Text Available Poput mnogi drugih suvremenih pojmova i pojam upravljanja odnosima s potrošačima (CRM u svakodnevnoj praksi izaziva dvojbe vezane za njegovo značenje i njegov obuhvat. Razlog tome treba tražiti u činjenici kako je CRM ujedno i strategija i proces i sustav, stoga je teško jednoznačno definirati pojam koji obuhvaća toliko široko područje. No, prilikom proučavanja CRM-a treba uzeti u obzir kako je to koncept razvijen u okvirima marketing odnosa i poslovne filozofije koja teži zadovoljavanjem individualnih potreba potrošača; potrošača učiniti zadovoljnim i kroz izgradnju sustavne interakcije s potrošačem, potrošača transformirati u klijenta. Kako bi se to uspjelo, potrebno je uspostaviti sustav komunikacije s potrošačem koji će osigurati neposrednu interakciju s potrošačem. Kroz takvu se interakciju potrošač od anonimne jedinke u masi potrošača transformira u individualiziranu i personaliziranu jedinku, o kojoj se sustavno prikupljaju informacije, ali i kojoj se sustavno pružaju informacije. Takav sustav komunikacije, posebice kada je riječ o većem broju potrošača, nije moguće izgraditi bez upotrebe suvremene informacijsko-komunikacijske tehnologije. Zbog toga se CRM sustav integrira u marketing i informacijske sustave, kao i menadžment. Prikupljeni su podatci u točki dodira temelj za kreiranje slike o potrošaču te učinkovito zadovoljavanje njegovih potreba. Takav sustav, također omogućava izbor kvalitetnih potrošača u smislu osiguranja lojalnosti kvalitetnih potrošača. Prema tome CRM omogućava izgradnju defanzivne marketinške strategije koja teži zadržavanju i boljem iskorištenju postojećih potrošača, što u naravi zahtjeva manje napora i sredstava za provedbu od ofanzivne marketinške strategije.

  17. The impact of removing financial incentives from clinical quality indicators: longitudinal analysis of four Kaiser Permanente indicators.

    NARCIS (Netherlands)

    Lester, H.; Schmittdiel, J.; Selby, J.; Fireman, B.; Campbell, S.M.; Lee, J.; Whippy, A.; Madvig, P.

    2010-01-01

    OBJECTIVE: To evaluate the effect of financial incentives on four clinical quality indicators common to pay for performance plans in the United Kingdom and at Kaiser Permanente in California. DESIGN: Longitudinal analysis. SETTING: 35 medical facilities of Kaiser Permanente Northern California,

  18. Un caso de aorta destrocardica o enfermedad azul permanente

    Directory of Open Access Journals (Sweden)

    Héctor Pedraza

    1935-11-01

    Full Text Available Se trata del niño E. S. de 28 meses de edad, que fue recibido por uno de nosotros en el Hospital de La Misericordia en los primeros días de mayo de 1935. El padre, oriundo, como su hijo, de la hacienda de "El Chocho", en el municipio de Fusagasugá, lo trajo a Bogotá con el objeto de que su hijo mejorara de una afección que la sufría permanentemente y desde los primeros momentos de su vida. El padre nos refiere que jamás el niño ha podido comer por más de unos cinco minutos, que el simple ejercicio de la succión del pezón de la madre o del chupo lo fatiga, que tiene que descansar cada momento, en tal forma que nunca queda satisfecho su apetito. Tampoco puede dormir tranquilo; varias veces, durante la noche o el día, se despierta asustado, fatigoso, sobresaltado. Dice que desde que nació le ha notado un tinte morado en los tegumentos y especialmente en las uñas, labios y en las conjuntivas oculares, color que lo ve aumentarse cuando el niño hace el ejercicio natural para comer o cuando se despierta repentinamente del sueño en que estaba. Además nota que el desarrollo no le satisface, es poco relativamente lo que ha crecido, tiene ya 28 meses y los padres se muestran afanosos porque no puede caminar y apenas trata de sentarse; los miembros, poco desarrollados, y su dentición comenzó únicamente a los 14 meses.

  19. La educación permanente y las plataformas web en España

    Directory of Open Access Journals (Sweden)

    Medina, Beatriz

    2014-04-01

    Full Text Available La Educación Permanente en España, actualmente disfrutando de una etapa de consolidación, está haciéndose eco de las novedades educativas relacionadas con las Tecnologías de la Información y la Comunicación. En este sentido, realizamos un estudio con el objetivo de conocer la presencia de la Educación Permanente en internet y su oferta formativa, para lograrlo utilizamos la metodología comparada. Las distintas administraciones competentes ofrecen una variada oferta de recursos en plataformas web para hacer más accesible la Educación Permanente. Entre los principales hallazgos tenemos que todas las comunidades y ciudades autónomas del país poseen páginas o portales web dirigidos a las personas adultas que se encuentran en esta etapa del sistema educativo español, excepto Baleares; solo la comunidad autónoma Andalucía tiene un portal exclusivo para la Educación Permanente.

  20. EDUCACIÓN PERMANENTE EN SERVICIO DE FORMACIÓN DE PROFESIONALES DE ENFERMERÍA

    Directory of Open Access Journals (Sweden)

    Rosa Gomes Ferreira

    2015-12-01

    Full Text Available A formação é um processo contínuo e deve estar presente no cotidiano de trabalho e para tal, surge a educação permanente, como pactuação teoria-prática. Nossos objetivos são o de descrever as práticas educativas em saúde, enfatizando a educação permanente e analisar os contrapontos e intersecções à efetividade da assistência, mediante a prática de educação permanente. Estudo qualitativo, descritivo, exploratório. O estudo aponta que a educação permanente emerge como ferramenta capaz de despertar desejo, no trabalhador, em discutir e refletir acerca da prática. No entanto, todas as práticas educativas, tal como a educação continuada, tem valor e penetrância no campo do trabalho.  DOI: http://dx.doi.org/10.12957/sustinere.2015.18127

  1. Kaiser Permanente's performance improvement system, part 2: developing a value framework.

    Science.gov (United States)

    Schilling, Lisa; Deas, Dennis; Jedlinsky, Maile; Aronoff, Deborah; Fershtman, Juliette; Wali, Abdul

    2010-12-01

    In 2008, Kaiser Permanente began phased implementation of a nationwide performance improvement (PI) system. The aim was to improve performance by providing consistent, highly meaningful performance measurement, increase PI skills in staff at all levels, develop organizational capabilities, and provide support for making improvements in medical centers and across regions. Evaluating the PI System: The intermediate results of the PI system were assessed in the 22 medical centers in four of the eight Kaiser Permanente regions. Implementation for 3 of these medical centers occurred in January 2008 through November 2008, with implementation for the remaining 19 medical centers occurring from September 2008 through September 2009. The 22 medical centers that were evaluated achieved a 61% improvement in selected capabilities, and improvement advisors (IAs) successfully completed 84% of initial PI projects. For each dollar invested, estimates suggested an average return on investment of $2.36. Critical factors include adequate dedicated time for PI activities by staff with necessary expertise, expert support to operations, alignment of projects with regional and national strategic priorities, and close working relationships between PI staff and operational management. Involving finance leaders in improvement planning, prioritization, and oversight is important. These elements can be adapted to smaller systems and single hospitals. The initial evaluation of the Kaiser Permanente PI system indicated that (1) IAs successfully led projects in conjunction with frontline teams, (2) organizational capabilities increased, and (3) the investment in PI infrastructure and staff was sound. Expansion throughout the entire Kaiser Permanente system is under way.

  2. Kaiser Permanente's performance improvement system, Part 1: From benchmarking to executing on strategic priorities.

    Science.gov (United States)

    Schilling, Lisa; Chase, Alide; Kehrli, Sommer; Liu, Amy Y; Stiefel, Matt; Brentari, Ruth

    2010-11-01

    By 2004, senior leaders at Kaiser Permanente, the largest not-for-profit health plan in the United States, recognizing variations across service areas in quality, safety, service, and efficiency, began developing a performance improvement (PI) system to realizing best-in-class quality performance across all 35 medical centers. MEASURING SYSTEMWIDE PERFORMANCE: In 2005, a Web-based data dashboard, "Big Q," which tracks the performance of each medical center and service area against external benchmarks and internal goals, was created. PLANNING FOR PI AND BENCHMARKING PERFORMANCE: In 2006, Kaiser Permanente national and regional continued planning the PI system, and in 2007, quality, medical group, operations, and information technology leaders benchmarked five high-performing organizations to identify capabilities required to achieve consistent best-in-class organizational performance. THE PI SYSTEM: The PI system addresses the six capabilities: leadership priority setting, a systems approach to improvement, measurement capability, a learning organization, improvement capacity, and a culture of improvement. PI "deep experts" (mentors) consult with national, regional, and local leaders, and more than 500 improvement advisors are trained to manage portfolios of 90-120 day improvement initiatives at medical centers. Between the second quarter of 2008 and the first quarter of 2009, performance across all Kaiser Permanente medical centers improved on the Big Q metrics. The lessons learned in implementing and sustaining PI as it becomes fully integrated into all levels of Kaiser Permanente can be generalized to other health care systems, hospitals, and other health care organizations.

  3. La incapacidad permanente y su impacto en el sistema español de Seguridad Social

    Directory of Open Access Journals (Sweden)

    César Luis Gómez Garcillán

    Full Text Available Se analizan datos de incapacidad permanente de los últimos años en la seguridad social. Conclusiones: El desglose provincial muestra grandes diferencias a nivel territorial cuyo origen o motivación no se puede determinar actualmente en tanto no se dispone de dos parámetros básicos, el código de diagnóstico de la patología principal determinante de la incapacidad permanente y el código identificativo de la actividad laboral (profesión habitual del interesado que permitirían realizar un análisis fiable de la situación. Entre los factores que podrían incidir de alguna manera en la mayor o menor incidencia de la incapacidad permanente, podemos analizar dos grandes componentes, la población protegida y su composición a nivel de regímenes y la iniciativa en la incoación de los procedimientos. El grupo de provincias con una incidencia más elevada en incapacidad permanente acusa tasas de paro también más elevadas que el grupo con incidencia menor. La tendencia en el número de procedimientos de IP incoados resulta claramente a la baja con una caída de más del 9% en cinco años. El INSS desestima un porcentaje creciente de los mismos, la razón de ese comportamiento no reside en una valoración restrictiva o más exigente por parte de la gestora, sino porque se instruyen menos procesos de incapacidad permanente y porque va tomando mayor protagonismo en la iniciativa de incoación el procedimiento a instancia de parte, cuyo porcentaje de desestimación es el más elevado.

  4. Matematika u vojnotehničkim dostignućima / Mathematics in military-technical achievements

    Directory of Open Access Journals (Sweden)

    Natalija B. Jelenković

    2010-10-01

    Full Text Available Matematika se definiše kao vrsta filozofije ili pogleda na svet, sredstvo za razvijanje apstraktnog mišljenja, a služi i za pojednostavljenje prirodnih nauka. Prilično je specijalna - izučava količinu i poredak; uopšteno, to je nauka o formalnim strukturama. Ona je i kombinacija slobode kreativne misli i strogih logičkih pravila, ali i deduktivna nauka koja daje pravila i zakone pomoću kojih baratamo brojevima i prostorom. Kao takva, matematika je i savremeni alat za vojnotehnička dostignuća modernog doba, kao što su: sve vrste radio i radio-relejnih veza, radarska sredstva, sredstva za upravljanje, navigaciju, televizijska, optoelektronska, hidro- akustična sredstva, sredstva za protivelektronsku borbu, kao i mnoga elektronska tehnička sredstava, naoružanje i vojna oprema Kopnene vojske, Vazduhoplovstva i protiv-vazduhoplovne odbrane, Ratne mornarice. Prethodno istaknute definicije matematike su korišćene kao osnova za uopšteno sistematizovano izlaganje metodom uporednog opisivanja, nabrajanjem činjenica, definisanjem pojmova. Cilj članka je da se na osnovu nabrojanja postojećih primena matematike i proširivanjem znanja može dalje napredovati u istraživanju mnogih vojnih oblasti. Pored toga, članak ima i pedagoški cilj, a to je da kroz opise i karakteristike sredstava ratne tehnike zainteresuje i afirmiše značaj i lepotu vojnog poziva. Rezultati razvoja informacionih tehnologija su, pored ostalog, i savršenija vojnotehnička dostignuća, a predstavljaju i inspiraciju za mnoge inovacije i uspehe. / In this article, mathematics is dealt with as a science necessary for the design, development and implementation of certain military-technical achievements such as many electronic devices, smart missiles, miniature antennas, camouflage military clothing and other military equipment. Some areas of applied, discrete and continuous mathematics are underlined in particular. Application of mathematics The importance of

  5. Building an industry-wide occupational exposure database for respirable mineral dust - experiences from the IMA dust monitoring programme

    International Nuclear Information System (INIS)

    Houba, Remko; Jongen, Richard; Vlaanderen, Jelle; Kromhout, Hans

    2009-01-01

    Building an industry-wide database with exposure measurements of respirable mineral dust is a challenging operation. The Industrial Minerals Association (IMA-Europe) took the initiative to create an exposure database filled with data from a prospective and ongoing dust monitoring programme that was launched in 2000. More than 20 industrial mineral companies have been collecting exposure data following a common protocol since then. Recently in 2007 ArboUnie and IRAS evaluated the quality of the collected exposure data for data collected up to winter 2005/2006. The data evaluated was collected in 11 sampling campaigns by 24 companies at 84 different worksites and considered about 8,500 respirable dust measurements and 7,500 respirable crystalline silica. In the quality assurance exercise four criteria were used to evaluate the existing measurement data: personal exposure measurements, unique worker identity, sampling duration not longer than one shift and availability of a limit of detection. Review of existing exposure data in the IMA dust monitoring programme database showed that 58% of collected respirable dust measurements and 62% of collected respirable quartz could be regarded as 'good quality data' meeting the four criteria mentioned above. Only one third of the measurement data included repeated measurements (within a sampling campaign) that would allow advanced statistical analysis incorporating estimates of within- and between-worker variability in exposure to respirable mineral dust. This data came from 7 companies comprising measurements from 23 sites. Problematic data was collected in some specific countries and to a large extent this was due to local practices and legislation (e.g. allowing 40-h time weighted averages). It was concluded that the potential of this unique industry-wide exposure database is very high, but that considerable improvements can be made. At the end of 2006 relatively small but essential changes were made in the dust monitoring

  6. Política de Educação Permanente em Saúde: análise de sua implementação

    Directory of Open Access Journals (Sweden)

    Katerine Gonçalves Moraes

    2015-12-01

    Full Text Available Introdução: A política nacional de educação permanente em saúde define novas diretrizes para a gestão democrática na área da educação na saúde, tais como: a gestão participativa, o protagonismo dos trabalhadores e usuários e o fortalecimento do controle social. Objetivo: Analisar o processo de implementação da Política de Educação Permanente em Saúde no Distrito Federal, Brasil. Métodos: Estudo de caso utilizando a teoria da política pública foi realizado no Distrito Federal, envolvendo 24 participantes chave responsáveis pela gestão e implementação dessa política. Resultados: Os achados apontam para um modelo centralizado de gestão com pouca participação de outros segmentos da sociedade civil, obstáculos de financiamento devido a questões burocráticas e desvalorização dos espaços de execução da política. Conclusão: Pode-se concluir que as mudanças políticas e de gestão não têm sido realizadas com a amplitude necessária para a construção coletiva do conhecimento nos serviços de saúde.

  7. Sulfosalt systematics: a review. Report of the sulfosalt sub-committee of the IMA Commission on Ore Mineralogy

    DEFF Research Database (Denmark)

    Moelo, Y.; Makovicky, E.; Mozgova, N.N.

    2008-01-01

    , Nomenclature and Classification (CNMNC-IMA). Part I presents generalities of sulfosalt definition and nomenclature. After an extended chemical definition of sulfosalts, attention is focused on "classic" sulfosalts with As3+, Sb3+, Bi3+ or Te4+ as cations, corresponding to the general formula (Me+, Me'(2+), etc......This report deals with a general reexamination of the systematics of sulfosalts. It represents an update of the activity of the Sulfosalt Sub-Committee within the Commission on Ore Mineralogy of the International Mineralogical Association, in connection with the Commission on New Minerals.......), [(Bi, Sb, As)(3+), Te4+](y) [(S, Se, Te)(2-)](z) (Me, Me': various metals). General aspects of their chemistry and classification principles are summarized, especially with regard to chemical substitutions and modular analysis of complex crystal structures. On this basis, Part II presents a review...

  8. EDUCAÇÃO PERMANENTE EM SAÚDE: Reflexões e desafios

    OpenAIRE

    Palhares Guimarães,Eliane Marina; Haueisen Martin,Sandra; Paolinelli Rabelo,Flávia Cristina

    2010-01-01

    Este trabalho é resultado de uma reflexão sobre o processo de educação permanente em saúde e na enfermagem. Tem como objetivo apresentar algumas perspectivas e tendências da educação em saúde e na enfermagem, com ênfase em educação permanente. Analisa a importância dos avanços tecnológicos e sua incorporação no processo de ensinar e de aprender. O texto é dividido em três partes, abordando inicialmente as mudanças organizacionais e, conseqüentemente, na educação, decorrentes da incorporação t...

  9. Los entornos personales de aprendizaje en el marco de la educación permanente

    Directory of Open Access Journals (Sweden)

    Elvira E. Navas

    2013-01-01

    Full Text Available En este trabajo se presenta un estudio documental sobre el surgimiento, evolución y estado actual de la utilización y desarrollo de los Entornos Personales de Aprendizaje (Personal Learning Environment, PLE en el marco de la Educación Permanente o Aprendizaje para Toda la vida (Lifelong Learning. En primer lugar, se hace una revisión del concepto de Educación Permanente desde la literatura de inicios de siglo XX. A continuación, se procede a estudiar el término PLE, desde sus orígenes hasta la interpretación actual. Se presentan experiencias tanto nacionales como internacionales donde se ejemplifica de forma práctica la utilización de PLE en la educación universitaria. Finalmente, se hace una reflexión de cierre sobre las proyecciones de futuro del uso de los PLE en el marco de la educación permanente.

  10. Kaiser Permanente's performance improvement system, Part 4: Creating a learning organization.

    Science.gov (United States)

    Schilling, Lisa; Dearing, James W; Staley, Paul; Harvey, Patti; Fahey, Linda; Kuruppu, Francesca

    2011-12-01

    In 2006, recognizing variations in performance in quality, safety, service, and efficiency, Kaiser Permanente leaders initiated the development of a performance improvement (PI) system. Kaiser Permanente has implemented a strategy for creating the systemic capacity for continuous improvement that characterizes a learning organization. Six "building blocks" were identified to enable Kaiser Permanente to make the transition to becoming a learning organization: real-time sharing of meaningful performance data; formal training in problem-solving methodology; workforce engagement and informal knowledge sharing; leadership structures, beliefs, and behaviors; internal and external benchmarking; and technical knowledge sharing. Putting each building block into place required multiple complex strategies combining top-down and bottom-up approaches. Although the strategies have largely been successful, challenges remain. The demand for real-time meaningful performance data can conflict with prioritized changes to health information systems. It is an ongoing challenge to teach PI, change management, innovation, and project management to all managers and staff without consuming too much training time. Challenges with workforce engagement include low initial use of tools intended to disseminate information through virtual social networking. Uptake of knowledge-sharing technologies is still primarily by innovators and early adopters. Leaders adopt new behaviors at varying speeds and have a range of abilities to foster an environment that is psychologically safe and stimulates inquiry. A learning organization has the capability to improve, and it develops structures and processes that facilitate the acquisition and sharing of knowledge.

  11. LA SELECCIÓN DE LOS BENEFICIARIOS PARA LOS PROGRAMAS CONTRA LA POBREZA: la experiencia del IMAS

    Directory of Open Access Journals (Sweden)

    Juan Diego Trejos Solórzano

    2007-12-01

    Full Text Available Resumen Los esfuerzos por erradicar la pobreza en el país han llevado a la creación de un amplio andamiaje institucional que ha requerido del desarrollo de sistemas de selección de la población beneficiaria con el fin de canalizar los recursos de manera más eficiente y eficaz. Dentro de estos esfuerzos, el IMAS es el que más ha avanzado y en este artículo se busca presentar y evaluar el sistema desarrollado, conocido como SIPO. Para ello se enmarca conceptualmente el enfoque en las políticas sociales selectivas, se analiza el sistema SIPO y se confronta con una base externa, la encuesta de ingresos y gastos, con el fin de determinar tanto su cobertura específica como su capacidad de enfoque. Se obtiene que el instrumento muestra una amplia capacidad potencial de enfoque, pero falla en alcanzar esa cobertura, que permitiría la inclusión de una parte significativa de la población pobre. Se concluye con algunas recomendaciones sobre posibles acciones a tomar para consolidar el sistema.   Abstract Efforts to eradicate poverty in the country have led to the creation of a broad institutional framework that has required the development of systems for selecting the target population in order to channel resources more efficiently and effectively. Within these efforts, the IMAS is the most advanced and this article seeks to present and evaluate the system developed, known as SIPO. The conceptual approach is based upon targeted social policies, the system SIPO is examined and confronted with an external basis, the income and expenditure survey, in order to determine its specific coverage as its focus ability. It turns out that the instrument has a wide potential in its focus ability, but fails to achieve a coverage broad enough to include a significant proportion of the poor population. It concludes with some recommendations on possible actions to be taken to strengthen the system.

  12. LA FORMACIÓN AMBIENTAL PERMANENTE DEL DIRECTIVO EDUCACIONAL DEL SIGLO XXI

    Directory of Open Access Journals (Sweden)

    Mavel Moré Estupiñán

    2013-12-01

    Full Text Available La situación ambiental actual impone nuevos retos a los sistemas educativos, entre ellos el de incorporar la educación ambiental para el desarrollo sostenible al proceso pedagógico en los diferentes subsistemas de educación. Para lograr este propósito, es decisivo el rol del directivo educacional, desde la implementación del sistema de dirección institucional. Por ello, la formación ambiental de este profesional constituye un imperativo y se declara como problema científico de la presente investigación, que se sustenta teórica y metodológicamente en los fundamentos de la formación ambiental permanente del directivo educacional y delimita como objetivo: proponer un Modelo para orientar hacia el desarrollo sostenible este proceso. Garantizan el cumplimiento del objetivo, el empleo de métodos teóricos, estadísticos y/o de procesamiento matemático y empíricos, de corte cuantitativo y cualitativo, que se articulan a partir de las técnicas de la investigación-acción-participativa. El Modelo constituye la contribución a la teoría pedagógica y son aportes de significación práctica los programas de las formas organizativas de la formación permanente. El criterio de la práctica, como resultado de la sistematización de una secuencia de ciclos, y las valoraciones de diferentes evaluadores confirman la pertinencia, relevancia y efectividad del Modelo de formación ambiental permanente del directivo educacional.

  13. Making the business case for hospital information systems--a Kaiser Permanente investment decision.

    Science.gov (United States)

    Garrido, Terhilda; Raymond, Brian; Jamieson, Laura; Liang, Louise; Wiesenthal, Andrew

    2004-01-01

    Further evidence in favor of the clinical IT business case is set forth in Kaiser Permanente's cost/benefit analysis for an electronic hospital information system. This article reviews the business case for an inpatient electronic medical record system, including 36 categories of quantifiable benefits that contribute to a positive cumulative net cash flow within an 8.5 year period. However, the business case hinges on several contingent success factors: leadership commitment, timely implementation, partnership with labor, coding compliance, and workflow redesign. The issues and constraints that impact the potential transferability of this business case across delivery systems raise questions that merit further attention.

  14. La normativa de atribución de rentas a establecimientos permanentes en Colombia

    OpenAIRE

    Navarro Ibarrola, Aitor

    2016-01-01

    En el presente trabajo se analizan las reglas para la determinación de la renta de establecimientos permanentes situados en Colombia. A tal efecto, el autor lleva a cabo un estudio sobre la base de las pautas que la OCDE establece en la materia, ya que el sistema de conceptos propuesto por este organismo internacional se adoptó como referencia por parte del legislador colombiano a partir de 2012. En concreto, en el marco del concepto de entidad funcionalmente separada, se analiza el contenido...

  15. Análisis de series temporales en estaciones permanentes GPS

    OpenAIRE

    García Cañada, Laura

    2016-01-01

    En los ultimos años el número de estaciones permanentes GPS ha aumentado considerablemente para diferentes aplicaciones geodésicas y se comienza a disponer de series de coordenadas suficientemente largas como para poder aplicar ánalisis de series temporales. El principal objetivo de esta tesis es estudiar la influencia de la red de estaciones utilizada, marco de referencia y/o estrategia de procesado en las series temporales de coordenadas de estaciones CGPS y todos aquellos parámetros que se...

  16. Análisis de series temporales en estaciones permanentes GPS

    OpenAIRE

    García Cañada, Laura

    2015-01-01

    En los ultimos años el número de estaciones permanentes GPS ha aumentado considerablemente para diferentes aplicaciones geodésicas y se comienza a disponer de series de coordenadas suficientemente largas como para poder aplicar ánalisis de series temporales. El principal objetivo de esta tesis es estudiar la influencia de la red de estaciones utilizada, marco de referencia y/o estrategia de procesado en las series temporales de coordenadas de estaciones CGPS y todos aquellos parámetros que s...

  17. The Kaiser Permanente Northwest Cardiovascular Risk Factor Management Program: A Model for All

    Science.gov (United States)

    Joyce, Jodi S; Fetter, Martina M; Klopfenstein, Dean H; Nash, Michael K

    2005-01-01

    Proof of the effectiveness of preventive measures that reduce established risk traits for atherothrombotic disorders has spurred attempts to systematically apply these interventions among susceptible populations. One such attempt is the Cardiovascular Risk Factor Management (CVRFM) Program, launched in 2003 to optimize clinical management and outcomes for 75,000 Kaiser Permanente Northwest Region (KPNW) members with atherosclerotic cardiovascular disease (CVD) or hypertension. The CVRFM Program is a centralized, multidisciplinary, proactive telephone-based clinical management intervention consisting of an “outreach” call, an interview, a mailed individualized care plan and information packet, regular follow-up (including protocolized medication management) and—when “goal status” is achieved—transfer of the patient to a maintenance plan. Quarterly evaluation of effectiveness entailed measurement of a range of clinical, utilization, and member satisfaction outcomes. Results by the fourth quarter were outstanding: For example, >98% of participants with coronary disease or diabetes had LDL cholesterol testing, >90% of coronary patients received aspirin or statin treatment, 99% were “extremely” or “very” satisfied with the program, and reductions were observed in the number of hospitalizations and visits to the emergency department and clinic. Mathematical models predict a decrease in myocardial infarctions and cardiovascular mortality within two years after implementing the program, the underlying principles of which should yield similar improvement in other Kaiser Permanente (KP) Regions and in other health care organizations. PMID:21660155

  18. Caracterização das atividades educativas de trabalhadores de enfermagem na ótica da educação permanente

    Directory of Open Access Journals (Sweden)

    Adriana Marques da Silva

    2009-09-01

    Full Text Available Este estudo discute a reciprocidade entre práticas de saúde e educativas e objetiva caracterizar os trabalhadores deenfermagem e suas atividades educativas em região do município de São Paulo. Estudo exploratório-descritivoquantitativo, realizado em 18 serviços de saúde entre 2005/2006, cuja coleta de dados foi feita por meio de entrevistae aplicação de dois formulários. Identificou-se que 84,8% dos trabalhadores de enfermagem atuam nos hospitais epronto socorro (PS; 22,5% são enfermeiros, 15,2%, técnicos de enfermagem (TE e 62,3%, auxiliares deenfermagem (AE. Das 245 ações educativas mapeadas, 78,4% são realizadas nos hospitais e PS,predominantemente, focadas na recuperação da saúde; 46,9% estão direcionadas aos enfermeiros, 39,6% aosenfermeiros, TE e AE e 13,5%, aos TE e AE; 21,2% ações utilizam estratégias tradicionais de ensino e 15,1%, asparticipativas; 69% têm duração de 01-20h; 55,5% são realizadas fora do serviço. Apesar de predominar atividadeseducativas voltadas aos enfermeiros, orientadas para recuperação da saúde, com utilização de estratégias de ensinotradicionais, a presença de ações ancoradas no cotidiano de trabalho, remete à concepção de educação permanente eassinala possibilidades de mudança da abordagem das práticas educativas de trabalhadores na perspectiva daintegralidade da saúde e do cuidado integral de enfermagem.

  19. Environmental policy. Resolution of the German Federal Government concerning the Air Pollution Abatement Programme of the Federal Republic of Germany based on the fourth report of the Interdepartmental Working Group on Carbon Dioxide Reduction (IMA `CO{sub 2} Reduction`); Umweltpolitik. Beschluss der Bundesregierung zum Klimaschutzprogramm der Bundesrepublik Deutschland auf der Basis des Vierten Berichts der Interministeriellen Arbeitsgruppe ``CO{sub 2}-Reduktion`` (IMA ``CO{sub 2}-Reduktion``)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    Air pollution abatement is a key issue in German environmental policy. This was stressed again in the 4th report of the Interdepartmental Working Group on Carbon Dioxide Reduction (IMA `CO{sub 2}-Reduktion`), in which the Federal Government confirmed its goal of a 25% reduction of carbon dioxide emissions by 2005 as referred to 1990. This report contains the government decision, the formulatio of the task assigned to the IMA, and the 4th report of the IMA. (orig./SR) [Deutsch] Klimavorsorge ist ein Schwerpunkt der deutschen Umweltpolitik. Dies hat das Bundeskabinett mit der Verabschiedung des 4. Berichts der Interministeriellen Arbeitsgruppe (IMA) ``CO{sub 2}-Reduktion`` nachdruecklich unterstrichen. Mit diesem Beschluss bekraeftigt die Bundesregierung erneut ihr Ziel, die CO{sub 2} Emissionen bis 2005 um 25 % gegenueber 1990 zu senken. Der vorliegende Bericht enthaelt den Beschluss, der Bundesregierung, den Auftrag der Bundesregierung an die Interministerielle Arbeitsgruppe (IMA) und den 4. Bericht der IMA ``CO{sub 2}-Reduktion``. (orig./SR)

  20. True NOTES TME resection with splenic flexure release, high ligation of IMA, and side-to-end hand-sewn coloanal anastomosis.

    Science.gov (United States)

    Marks, John H; Lopez-Acevedo, Nicolas; Krishnan, Barath; Johnson, Matthew N; Montenegro, Grace A; Marks, Gerald J

    2016-10-01

    Natural orifice transluminal endoscopic surgery (NOTES) represents the ultimate expression of minimally invasive surgery. We have developed and present here an initial feasibility and safety study of transanal total mesorectal excision (TME) with splenic flexure release, high ligation of the IMA and IMV, and side-to-end coloanal anastomosis with temporary diverting ileostomy for rectal cancer. A program of full NOTES TME resection with release of the splenic flexure, high ligation of the IMA/IMV, with side-to-end coloanal anastomosis was performed transanally from December 2013 to July 2014. Demographics, preoperative, perioperative, and postoperative data were prospectively obtained. Operative components were broken into TME, colonic mobilization, splenic flexure release, IMA/IMV transection, transanal extraction of specimen, and coloanal anastomosis for analysis of performance completion. There were 3 women and 1 man on whom we operated. Mean age was 56 (46-65). Mean BMI was 26 (23.8-30.2). The operation was completed entirely transanally in 2 patients. Transanal component completion of the operation was as follows: TME in 3/4; colonic mobilization in 4/4; splenic flexure release in 3/4; IMA/IMV transection in 3/4; transanal specimen extraction in 4/4; coloanal anastomosis in 4/4. Abdominal time for completion of component parts was: splenic flexure release 4:53 (min:s), IMA/IMV 19:43, completion of TME 13:41. Mean EBL was 194 cc (25-500). Aside from stoma site, there were no abdominal incisions. There were no mortalities. Mesorectum was intact in all 4 patients and with negative circumferential and distal margins. This experience supports the feasibility and safety of a true NOTES TME. The critical anatomic views demonstrated on video affirm the potential of this approach for distal rectal cancer. Colorectal surgery represents the most logical application for NOTES. While highly promising, a great deal of work remains to develop the technique and applicability

  1. Kaiser Permanente-Sandia National Health Care Model: Phase 1 prototype final report. Part 2 -- Domain analysis

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, D.; Yoshimura, A.; Butler, D.; Judson, R.; Mason, W.; Napolitano, L.; Mariano, R. [Sandia National Labs., Livermore, CA (United States); Eddy, D.; Schlessinger, L. [Kaiser Permanente, Pasadena, CA (United States)

    1996-11-01

    This report describes the results of a Cooperative Research and Development Agreement between Sandia National Laboratories and Kaiser Permanente Southern California to develop a prototype computer model of Kaiser Permanente`s health care delivery system. As a discrete event simulation, SimHCO models for each of 100,000 patients the progression of disease, individual resource usage, and patient choices in a competitive environment. SimHCO is implemented in the object-oriented programming language C{sup 2}, stressing reusable knowledge and reusable software components. The versioned implementation of SimHCO showed that the object-oriented framework allows the program to grow in complexity in an incremental way. Furthermore, timing calculations showed that SimHCO runs in a reasonable time on typical workstations, and that a second phase model will scale proportionally and run within the system constraints of contemporary computer technology.

  2. Offre pour nos membres

    CERN Multimedia

    Staff Association

    2016-01-01

    Walibi Rhône-Alpes accueille son événement Halloween FreakShow le week-end du 15 et 16 octobre puis tous les jours du 20 octobre au 02 novembre 2016 ! ouverture prolongée jusqu’à 19h et feu d’artifices chaque soir 29, 30 et 31 octobre ! Loup-garou show; 1 labyrinthe; jeu de piste sur le parc (et nombreux lots à gagner); animations (sculpture sur citrouilles et maquillage) et d'autres surpises ! Tarifs pour nos membres : Entrée "Zone terrestre": 23 € au lieu de 29 €. Entrée gratuite pour les enfants de moins de 3 ans, avec accès aux attractions limité. Parking gratuit.

  3. Resultados da correção cirúrgica da exotropia permanente em pacientes amblíopes e não-amblíopes

    Directory of Open Access Journals (Sweden)

    Adriana Valim Portes

    2011-08-01

    Full Text Available A exotropia permanente (XT acomete cerca de 1 a 2% da população. Seu tratamento é clínico: antiambliogênico e correção dos erros refrativos, e cirúrgico. O objetivo do tratamento cirúrgico é alinhar os olhos na posição primária do olhar, proporcionando melhor resultado estético. Há muito tempo diversos autores estudam os fatores pré, per e pós-operatórios relacionados ao resultado cirúrgico, uma vez que a taxa de sucesso varia de 60 a 80%. Ainda são poucos os estudos que comparam a presença de ambliopia como fator de influência no resultado final. OBJETIVO: Comparar o resultado cirúrgico dos pacientes amblíopes e não-amblíopes submetidos à cirurgia de correção de XT. MÉTODOS: Análise retrospectiva de 37 prontuários de pacientes amblíopes (Grupo A e não-amblíopes (Grupo B submetidos à correção cirúrgica de XT por retrocessoressecção monocular, sendo avaliados os registros pós-operatórios imediatos e tardios. Idade: grupo A 24,7 ± 14,2 anos, grupo B 22,6 ±18,6 anos; Desvio pré-operatório: grupo A 29,1± 7,2Δ, grupo B 28,4 ± 6,8Δ. RESULTADOS: A taxa de sucesso foi de 60% e 100% (p<0,05, no pós-operatório imediato e 50% e 82,3% (p=0,082, no pós-operatório final, nos grupos A e B, respectivamente. Não houve diferença significante quanto aos desvios pós-operatórios imediatos, tardios e variação do desvio. CONCLUSÃO: Pode-se concluir que o grupo B mostrou melhor resultado no pós-operatório imediato; porém não houve diferença no resultado cirúrgico de correção de exotropia permanente entre pacientes amblíopes e não-amblíopes no período pós-operatório de seis meses.

  4. The implementation of CMOS sensors within a real time digital mammography intelligent imaging system: The I-ImaS System

    Science.gov (United States)

    Esbrand, C.; Royle, G.; Griffiths, J.; Speller, R.

    2009-07-01

    The integration of technology with healthcare has undoubtedly propelled the medical imaging sector well into the twenty first century. The concept of digital imaging introduced during the 1970s has since paved the way for established imaging techniques where digital mammography, phase contrast imaging and CT imaging are just a few examples. This paper presents a prototype intelligent digital mammography system designed and developed by a European consortium. The final system, the I-ImaS system, utilises CMOS monolithic active pixel sensor (MAPS) technology promoting on-chip data processing, enabling the acts of data processing and image acquisition to be achieved simultaneously; consequently, statistical analysis of tissue is achievable in real-time for the purpose of x-ray beam modulation via a feedback mechanism during the image acquisition procedure. The imager implements a dual array of twenty 520 pixel × 40 pixel CMOS MAPS sensing devices with a 32μm pixel size, each individually coupled to a 100μm thick thallium doped structured CsI scintillator. This paper presents the first intelligent images of real breast tissue obtained from the prototype system of real excised breast tissue where the x-ray exposure was modulated via the statistical information extracted from the breast tissue itself. Conventional images were experimentally acquired where the statistical analysis of the data was done off-line, resulting in the production of simulated real-time intelligently optimised images. The results obtained indicate real-time image optimisation using the statistical information extracted from the breast as a means of a feedback mechanisms is beneficial and foreseeable in the near future.

  5. Permanent education in health. An instrument to enhance interpersonal relations in nursing work La educación permanente en salud. Instrumento potenciador de las relaciones interpersonales del trabajo en enfermería Educação permanente em saúde. Instrumento potencializador das relações interpessoais no trabalho da enfermagem

    Directory of Open Access Journals (Sweden)

    Juliane Portella Ribeiro

    2012-08-01

    ção com direção na técnica do trabalho, nos processos educativos, como estratégia de capacitação para os serviços de saúde, acaba por reforçar a fragmentação do cuidado, das equipes e do processo de trabalho. Conclui-se que a Educação Permanente em Saúde, além de servir como prática de ensino e aprendizagem para a atualização e transformação das práticas, atua nas relações da equipe, transformando os processos de ação conjunta e, ao mesmo tempo, implicando cada sujeito-trabalhador envolvido nas práticas de saúde.

  6. Is the Kaiser Permanente model superior in terms of clinical integration?: a comparative study of Kaiser Permanente, Northern California and the Danish healthcare system.

    Science.gov (United States)

    Strandberg-Larsen, Martin; Schiøtz, Michaela L; Silver, Jeremy D; Frølich, Anne; Andersen, John S; Graetz, Ilana; Reed, Mary; Bellows, Jim; Krasnik, Allan; Rundall, Thomas; Hsu, John

    2010-04-08

    Integration of medical care across clinicians and settings could enhance the quality of care for patients. To date, there is limited data on the levels of integration in practice. Our objective was to compare primary care clinicians' perceptions of clinical integration and three sub-aspects in two healthcare systems: Kaiser Permanente, Northern California (KPNC) and the Danish healthcare system (DHS). Further, we examined the associations between specific organizational factors and clinical integration within each system. Comparable questionnaires were sent to a random sample of primary care clinicians in KPNC (n = 1103) and general practitioners in DHS (n = 700). Data were analysed using multiple logistic regression models. More clinicians in KPNC perceived to be part of a clinical integrated environment than did general practitioners in the DHS (OR = 3.06, 95% CI: 2.28, 4.12). Further, more KPNC clinicians reported timeliness of information transfer (OR = 2.25, 95% CI: 1.62, 3.13), agreement on roles and responsibilities (OR = 1.79, 95% CI: 1.30, 2.47) and established coordination mechanisms in place to ensure effective handoffs (OR = 6.80, 95% CI: 4.60, 10.06). None of the considered organizational factors in the sub-country analysis explained a substantial proportion of the variation in clinical integration. More primary care clinicians in KPNC reported clinical integration than did general practitioners in the DHS. Focused measures of clinical integration are needed to develop the field of clinical integration and to create the scientific foundation to guide managers searching for evidence based approaches.

  7. Formación permanente del profesorado en Jalisco: evaluación y propuesta

    OpenAIRE

    Camacho Buenrostro, Benita

    2016-01-01

    Este trabajo tiene como objetivo realizar una evaluación del modelo de formación permanente para docentes de Educación Básica implementado en Jalisco durante el período 2007-2012. La investigación se ubica en el paradigma naturalista o interpretativo y busca lograr el objetivo a través del enfoque de la evaluación comprensiva. También utiliza métodos cualitativo y cuantitativo y se apoya en distintas técnicas: análisis de documentos, observación directa de este fenómeno, entrevistas a funcion...

  8. Educação permanente no contexto da enfermagem e na saúde

    OpenAIRE

    Mancia,Joel Rolim; Cabral,Leila Chaves; Koerich,Magda Santos

    2004-01-01

    Neste trabalho os autores discutem a proposta atual de educação permanente do Ministério da Saúde, voltada para a formação de recursos humanos para o Sistema Único de Saúde. Traz um resgate da educação em geral e especificamente da educação de adultos, questão que afeta diretamente a enfermagem, visto que esta contribui com o maior contingente de trabalhadoras na área da saúde, constituindo-se em foco central das políticas públicas. Assim apresentam as principais controvérsias e apontam para ...

  9. A retrospective analysis of health systems in Denmark and Kaiser Permanente

    DEFF Research Database (Denmark)

    Frølich, Anne; Schiøtz, Michaela L; Strandberg-Larsen, Martin

    2008-01-01

    ABSTRACT: BACKGROUND: To inform Danish health care reform efforts, we compared health care system inputs and performance and assessed the usefulness of these comparisons for informing policy. METHODS: Retrospective analysis of secondary data in the Danish Health Care System (DHS) with 5.3 million...... citizens and the Kaiser Permanente integrated delivery system (KP) with 6.1 million members in California. We used secondary data to compare population characteristics, professional staff, delivery structure, utilisation and quality measures, and direct costs. We adjusted the cost data to increase...... comparability. RESULTS: A higher percentage of KP patients had chronic conditions than did patients in the DHS: 6.3% vs. 2.8% (diabetes) and 19% vs. 8.5% (hypertension), respectively. KP had fewer total physicians and staff compared to DHS, with134 physicians/100,000 individuals versus 311 physicians/100...

  10. Tratamiento de un molar permanente inmaduro necrótico mediante pulpotomía

    OpenAIRE

    Boj Quesada, Juan Ramón; Cortés Lillo, Olga; Canalda Sahli, Carlos

    1995-01-01

    Se describe un caso que afecta al primer molar permanente inferior derecho, con tumefacción, fluctuación y fístula , con ápices no cerrados. El tratamiento de elección hubiese sido una técnica clásica de apicoformación con hidróxido de calcio. Pero por motivos de colaboración, se realizó una pulpotomía con hidróxido de calcio. Tras los controles radiológicos a los 3 meses, al año y al año y medio se comprobó que continuaba el desarrollo radicular y finalizaba el cierre apical.

  11. Probabilidad de retención de segundos molares permanentes mandibulares (Estudio piloto

    Directory of Open Access Journals (Sweden)

    Paulo Sandoval Vidal

    Full Text Available Objetivos: Determinar la frecuencia del segundo molar mandibular permanente (MM2 con probabilidad de impactación, en un grupo de pacientes de Ortodoncia de Temuco, Chile. Método: Estudio de corte transversal, con muestra por conveniencia. Se revisaron 2095 fichas de individuos de ambos sexos, con ausencia de patología sindrómica. Los datos recolectados se obtuvieron de radiografías panorámicas. Se midió el ángulo del segundo molar con respecto al plano oclusal, la invasión distal del primer molar y la distancia entre distal del primer molar y el borde anterior de la rama mandibular. Resultados: El promedio de edad de los pacientes relevados fue de 10 años. Se observó un 1,43% de probabilidad de retención de MM2 (n=30; en promedio y el plano el ángulo MM2 resultó de 27° el izquierdo y 26° el derecho; la invasión de MM2 en distal del primer molar resultó de 1,5 mm; el ángulo entre MM2 y el planos oclusal es de 123°; la distancia entre la cara distal del primer molar y el borde anterior de la rama mandibular fue 13 mm. Conclusiones: Existe una baja prevalencia de segundos molares mandibulares permanentes con probabilidad de impactación. La invasión a la cara distal del primer molar fue mayor en pacientes con riesgo de impactación

  12. Prevalencia preoperatoria de la fibrilación auricular permanente en cirugía cardíaca

    Directory of Open Access Journals (Sweden)

    Fernando Hornero

    2005-07-01

    Conclusiones: La FA permanente se presenta en nuestro medio quirúrgico preoperatorio en el 13,6%, preferentemente asociada a enfermedad mitral. Los factores de riesgo cardiovasculares están presentes con similar prevalencia en los pacientes con FA que en el resto, excepto el tamaño auricular.

  13. Kinetics and oxidative mechanism for H2O2-enhanced iron-mediated aeration (IMA) treatment of recalcitrant organic compounds in mature landfill leachate

    International Nuclear Information System (INIS)

    Deng Yang; Englehardt, James D.

    2009-01-01

    A hydrogen peroxide (H 2 O 2 )-enhanced iron (Fe 0 )-mediated aeration (IMA) process has been recently demonstrated to effectively remove organic wastes from mature landfill leachate. In this paper, the kinetics and oxidative mechanisms of the enhanced IMA treatment were studied. Bench-scale full factorial tests were conducted in an orbital shaker reactor for treatment of a mature leachate with an initial chemical oxygen demand (COD) of 900-1200 mg/L. At the maximum aeration rate (8.3 mL air/min mL sample), process variables significantly influencing the rates of H 2 O 2 decay and COD removal were pH (3.0-8.0), initial H 2 O 2 doses (0.21-0.84 M), and Fe 0 surface area concentrations (0.06-0.30 m 2 /L). Empirical kinetic models were developed and verified for the degradation of H 2 O 2 and COD. High DO maintained by a high aeration rate slowed the H 2 O 2 self-decomposition, accelerated Fe 0 consumption, and enhanced the COD removal. In hydroxyl radical (OH·) scavenging tests, the rate of removal of glyoxylic acid (target compound) was not inhibited by the addition of para-chlorobenzoic acid (OH· scavenger) at pH 7.0-7.5, ruling out hydroxyl radical as the principal oxidant in neutral-weakly basic solution. These experimental results show that this enhanced IMA technology is a potential alternative for the treatment of high strength recalcitrant organic wastewaters.

  14. Kinetics and oxidative mechanism for H2O2-enhanced iron-mediated aeration (IMA) treatment of recalcitrant organic compounds in mature landfill leachate.

    Science.gov (United States)

    Deng, Yang; Englehardt, James D

    2009-09-30

    A hydrogen peroxide (H(2)O(2))-enhanced iron (Fe(0))-mediated aeration (IMA) process has been recently demonstrated to effectively remove organic wastes from mature landfill leachate. In this paper, the kinetics and oxidative mechanisms of the enhanced IMA treatment were studied. Bench-scale full factorial tests were conducted in an orbital shaker reactor for treatment of a mature leachate with an initial chemical oxygen demand (COD) of 900-1200 mg/L. At the maximum aeration rate (8.3 mL air/min mL sample), process variables significantly influencing the rates of H(2)O(2) decay and COD removal were pH (3.0-8.0), initial H(2)O(2) doses (0.21-0.84 M), and Fe(0) surface area concentrations (0.06-0.30 m(2)/L). Empirical kinetic models were developed and verified for the degradation of H(2)O(2) and COD. High DO maintained by a high aeration rate slowed the H(2)O(2) self-decomposition, accelerated Fe(0) consumption, and enhanced the COD removal. In hydroxyl radical (OH*) scavenging tests, the rate of removal of glyoxylic acid (target compound) was not inhibited by the addition of para-chlorobenzoic acid (OH* scavenger) at pH 7.0-7.5, ruling out hydroxyl radical as the principal oxidant in neutral-weakly basic solution. These experimental results show that this enhanced IMA technology is a potential alternative for the treatment of high strength recalcitrant organic wastewaters.

  15. Kinetics and oxidative mechanism for H{sub 2}O{sub 2}-enhanced iron-mediated aeration (IMA) treatment of recalcitrant organic compounds in mature landfill leachate

    Energy Technology Data Exchange (ETDEWEB)

    Deng Yang, E-mail: yang.deng@upr.edu [Department of Civil Engineering and Surveying, University of Puerto Rico, PO BOX 9041, Mayaguez, PR 00681 (Puerto Rico); Englehardt, James D. [Department of Civil, Architectural and Environmental Engineering, University of Miami, PO BOX 248294, Coral Gables, FL 33124-0630 (United States)

    2009-09-30

    A hydrogen peroxide (H{sub 2}O{sub 2})-enhanced iron (Fe{sup 0})-mediated aeration (IMA) process has been recently demonstrated to effectively remove organic wastes from mature landfill leachate. In this paper, the kinetics and oxidative mechanisms of the enhanced IMA treatment were studied. Bench-scale full factorial tests were conducted in an orbital shaker reactor for treatment of a mature leachate with an initial chemical oxygen demand (COD) of 900-1200 mg/L. At the maximum aeration rate (8.3 mL air/min mL sample), process variables significantly influencing the rates of H{sub 2}O{sub 2} decay and COD removal were pH (3.0-8.0), initial H{sub 2}O{sub 2} doses (0.21-0.84 M), and Fe{sup 0} surface area concentrations (0.06-0.30 m{sup 2}/L). Empirical kinetic models were developed and verified for the degradation of H{sub 2}O{sub 2} and COD. High DO maintained by a high aeration rate slowed the H{sub 2}O{sub 2} self-decomposition, accelerated Fe{sup 0} consumption, and enhanced the COD removal. In hydroxyl radical (OH{center_dot}) scavenging tests, the rate of removal of glyoxylic acid (target compound) was not inhibited by the addition of para-chlorobenzoic acid (OH{center_dot} scavenger) at pH 7.0-7.5, ruling out hydroxyl radical as the principal oxidant in neutral-weakly basic solution. These experimental results show that this enhanced IMA technology is a potential alternative for the treatment of high strength recalcitrant organic wastewaters.

  16. Study of adverse events following immunisation with universal and newer vaccines in the Serampore IMA Child Clinic over a period of 7 years.

    Science.gov (United States)

    Das, Pradip Kumar

    2013-04-01

    Immunisation is an important part of childcare practice. It is one of the most beneficial and cost effective measures for the prevention of diseases. From the previous retrospective studies, it was evident that smallpox has been completely eradicated throughout now-a-days with the wholehearted and sincere efforts of healthcare providers by applying efficient and safe vaccine against smallpox, same is true also to polio which is now close to worldwide eradication and measles and rubella are no longer endemic in certain parts of the world. Not only has that with the introduction of safer and more efficient newer vaccines, the incidence of most other vaccine preventable disease of childhood also reduced considerably. The aim of the present study is to estimate the incidence and clinical presentation of adverse events following immunisation with universal and newer vaccines for a period of seven years using prospective active surveillance. Children under the age of 7 years were taken for universal and newer scheduled vaccinations given in the Serampore IMA Child Clinic under the supervision of the clinicians maintaining strictly the guidelines of Expanded Programme of Immunisation (Government of India). This study of adverse events following immunisation in the Serampore IMA Child Clinic confirms that the adverse events such as fever (0.37%), pain and swelling at the site of injection (0.32%0, urticarial rash (0.02%), anaphylactic shock (0.003%) are negligible. There were only two reports of anaphylaxis following preschool and infant schedule vaccines, including measles, mumps and rubella (MMR), Haemophilus influenzae type B vaccines and typhoid vaccines in approximately 52,000 infants received over a period of 7 years starting from 1st April, 2005 to 31st March, 2012 and there were no deaths or longterm effects reported during the post follow-up period in the Serampore IMA Child Clinic.

  17. Rasprava o osiguranju kvalitete softvera u malim i srednjim poduzećima za proizvodnju softvera: empirijsko istraživanje

    OpenAIRE

    Pusatli, O. Tolga; Misra, Sanjay

    2011-01-01

    U okviru proučavanja osnovnih aktivnosti uključujući ispitivanje, pregled i testiranje softvera prema postignutom nivou osiguranja kvalitete u malim i srednjim poduzećima (SMEs), članak daje suvremeni pogled na takve kompanije u odnosu na mjere u osiguranju kvalitete. Iznose se rezultati lokalnog empirijskog ispitivanja standarda kvalitete u turskoj industriji proizvodnje softvera. Istraženo je stanje u oko 150 softverskih kompanija od kojih se 17, da bi osigurale kvalitetu softvera pridržava...

  18. Primjena podvodne masaže zračnim mjehurićima kod oboljelih od multiple skleroze – opservacijska pilot-studija

    OpenAIRE

    RENDULIĆ SLIVAR, Senka; KRAML, Oto

    2010-01-01

    Podvodna masaža zračnim mjehurićima – biserna kupka, jedan je od oblika hidroterapije. Podatci iz nekih studija pokazuju da biserna kupka može dovesti do subjektivnog poboljšanja u aktivnostima svakodnevnog života. U radu je provedena usporedba primjene biserne kupke u bolesnika s multiplom sklerozom u specijalnoj bolnici za medicinsku rehabilitaciju i u kućnim uvjetima. U istraživanje je uključeno 15 ispitanika obaju spolova. Oni su prema uputama specijalista fizijatra tri tjedna svaki drugi...

  19. Prijedlog dorade pravnog režima za nautički turizam radi podizanja njegove konkurentnosti

    Directory of Open Access Journals (Sweden)

    Petar Kragić

    2018-02-01

    Full Text Available Cilj rada je predložiti određene dorade u domaćem pravnom režimu za nautički turizam radi podizanja njegove konkurentnosti. Pomorskopravni odnosi su specifični zbog međunarodnog karaktera plovidbe i konkurencije pravnih režima više država u uređenju pravnih odnosa koji proističu iz plovidbe. Zato, sugerira autor, za ocjenu da li je neka država pomorska nije odlučna dužina ili razvedenost njene obale, već da li njena vlada razumije specifične odnose vezane za pomorstvo i da li ih uređuje na način koji omogućuje razvoj pomorske privrede. Europska unija je prepoznala specifičnost pomorstva i dopustila svojim članicama da urede porezni sustav za brodarstvo drugačije od općeg poreznog sustava. Sada bi, drži autor, poseban sustav za uređenje nautičkog turizma trebalo kreirati i za jahte, u kojem niz odnosa – vezanih za tu djelatnost – treba urediti drugačije od općih odredbi. Sve to u cilju podizanja konkurentnosti hrvatskog nautičkog turizma, koji se bori na tržištu Sredozemlja s drugim, posebice za velike jahte, vrlo atraktivnim destinacijama. U radu se obrađuju administrativne procedure; kabotaža u uvjetima članstva u Europskoj uniji; porez na dodanu vrijednost na najamninu jahti; boravak posade jahti u Hrvatskoj; porezi na dohodak i doprinosi članova posade jahte; porez po tonaži i privremeni uvoz jahti. Posebice se razmatra članstvo Hrvatske u Europskoj uniji koje donosi prilike, ali i nameće ograničenja za standardne mjere protekcionizma i intervencionizma koje su povijesno koristile zemlje u razvoju da dostignu one razvijene. Ovaj je rad dio prijedloga većeg zahvata u zakonodavstvo za izmjenu određenog broja zakonskih rješenja primjenjivih na nautički turizam, koja nisu logična ili optimalna za tu gospodarsku granu.

  20. j_ima_mosaic

    DEFF Research Database (Denmark)

    2010-01-01

    Mosaicking software for JEM-X images included in the INTEGRAL Offline Science Analysis (OSA) software maintained by ISDC, University of Geneva, Switzerland. It is a C-program running under UNIX and Linux to merge images obtained by the JEM-X telescope and weighted by their relative exposure time...

  1. NOAA NOS SOS, EXPERIMENTAL - Currents

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have currents data. *These services are for testing and evaluation use...

  2. NOAA NOS SOS, EXPERIMENTAL - Wind

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have wind data. *These services are for testing and evaluation use only*...

  3. Gestão participativa na educação permanente em saúde: olhar das enfermeiras Gestión participativa en la educación permanente en salud: visión de las enfermeras Participative management in permanent health education: view of the nurses

    Directory of Open Access Journals (Sweden)

    Adriane Calvetti de Medeiros

    2010-02-01

    Full Text Available Este estudo de abordagem qualitativa teve como objetivo conhecer as estratégias de gestão, com base na Educação Permanente em Saúde (EPS. Os participantes da pesquisa foram seis enfermeiras assistenciais de uma unidade de terapia intensiva de um hospital universitário do Estado do Rio Grande do Sul. Utilizou-se como instrumento de coleta de dados o Método de Círculo de Cultura de Freire. Os dados foram coletados nos meses de junho a agosto/2007. Os resultados apontam para o planejamento participativo e tomada de decisão como estratégias da EPS que promovem a autonomia, a valorização, a competência técnica e a construção do trabalho em equipe, em seu próprio percurso de aprendizagem.Este estudio de abordaje cualitativa tuvo como objetivo conocer las estrategias de gestión, con base en la Educación Permanente en Salud (EPS. Los participantes de la investigación fueron seis enfermeras asistenciales de una unidad de terapia intensiva de un hospital universitario del Estado de Rio Grande do Sul. Se utilizó como instrumento de recollección de datos el Método de Círculo de Cultura de Freire. Los dados fueran recogidos en los meses de junio a agosto/2007. Los resultados apuntan para la planificación participativo y toma de decisión como estrategias de la EPS que promueven la autonomía, la valorización, la competencia técnica y la construcción del trabajo en equipo, en su propio recorrido de aprendizajeThis study is of qualitative approach, and aimed at knowing the management strategies, on the basis of the Permanent Education in Health (PEH. The participants of the research had been six nurses of an intensive care unit from an university hospital in the State of Rio Grande do Sul, Brazil. The Method Circle of Culture of Freire was used like as instrument for collection of data. The data were collected in the period from June to august, 2007. Results point out participative planning and decision making as strategies of the

  4. EDUCAÇÃO PERMANENTE EM ENFERMAGEM E A INTERFACE COM A OUVIDORIA HOSPITALAR

    Directory of Open Access Journals (Sweden)

    Raquel Costa Rodrigues de Souza

    2010-01-01

    Full Text Available Se trata de un estudio descriptivo-exploratorio, con enfoque cualitativo, cuyo objetivo fue investigar las demandas de los usuarios del servicio de Defensoría del Pueblo relacionadas con la asistencia de enfermería y discutir su contribución para la educación permanente. La investigación se desarrolló en hospital público federal, con notoriedad en realización de procedimientos diagnósticos y terapéuticos de alta complejidad en Ortopedia. La recolección de datos se basó en la técnica de análisis documental, incluyendo la gestión de informaciones y materiales, de las demandas de los usuarios que figuran en los registros de la Oficina de Defensoría del Pueblo, relativos al año 2009, (total de 3.895 declaraciones. Hemos clasificado las declaraciones recibidas- en este estudio- según la naturaleza de la comunicación: elogio, pedido de información, queja, sugerencia y denuncia. Hemos considerado la importancia del Servicio de Defensoría del Pueblo para mejorar la actuación de enfermería, teniendo en cuenta las contribuciones extraídas del contexto de las demandas y que la relación interdisciplinar permite percibir y evaluar las necesidades evidenciadas.

  5. CONTROL DE GESTIÓN: DIMENSIONES Y DIAGNÓSTICO PERMANENTE

    Directory of Open Access Journals (Sweden)

    Maritza Hernández Torres

    2003-04-01

    Full Text Available

    Los actuales entornos competitivos en los que se desarrolla la actividad empresarial, junto a la necesidad de responder de forma adecuada a los continuos cambios y constante incertidumbre a los que las organizaciones han de enfrentarse, conllevan una significativa modificación en lo que a la gestión empresarial se refiere, resultando esencial en este sentido, el papel del control de gestión, que como elemento del proceso de dirección, es el que más contribuye a mejorar las actuaciones de cualquier sistema. Las empresas deben tomar decisiones estratégicas adecuadas que permitan alcanzar alguna ventaja competitiva en la búsqueda de la excelencia empresarial a través de un proceso flexible de mejora continua. Para contribuir a tal propósito, en el presente trabajo se realizan algunas reflexiones acerca del control de gestión, abarcando desde el enfoque clásico hasta el moderno, su evolución y situación en las organizaciones cubanas; así como, el análisis de sus dimensiones soportado en un procedimiento para su permanente diagnóstico en correspondencia con las particularidades en que las diferentes empresas desarrollan su actividad.

  6. Breaching the security of the Kaiser Permanente Internet patient portal: the organizational foundations of information security.

    Science.gov (United States)

    Collmann, Jeff; Cooper, Ted

    2007-01-01

    This case study describes and analyzes a breach of the confidentiality and integrity of personally identified health information (e.g. appointment details, answers to patients' questions, medical advice) for over 800 Kaiser Permanente (KP) members through KP Online, a web-enabled health care portal. The authors obtained and analyzed multiple types of qualitative data about this incident including interviews with KP staff, incident reports, root cause analyses, and media reports. Reasons at multiple levels account for the breach, including the architecture of the information system, the motivations of individual staff members, and differences among the subcultures of individual groups within as well as technical and social relations across the Kaiser IT program. None of these reasons could be classified, strictly speaking, as "security violations." This case study, thus, suggests that, to protect sensitive patient information, health care organizations should build safe organizational contexts for complex health information systems in addition to complying with good information security practice and regulations such as the Health Insurance Portability and Accountability Act (HIPAA) of 1996.

  7. Las Lesson Study en Andalucía: un modelo de formación permanente

    Directory of Open Access Journals (Sweden)

    Rosa M.ª Caparrós Vida

    2015-01-01

    Full Text Available El presente artículo ofrece los resultados de un estudio de casos desarrollado en el marco de un proyecto de investigación I+D de la Universidad de Málaga a través de una de las modalidades de formación permanente ofertadas por un Centro de Formación del Profesorado, bajo la demanda de un grupo de docentes de una escuela de la comarca de la Axarquía en Málaga. Las Lesson Study se convierten en el eje del estudio de los procesos de comprensión y reconstrucción del conocimiento práctico de una maestra de 1º de primaria sobre la enseñanza y el aprendizaje de la lectura y escritura, encontrando evidencias significativas sobre cómo esta estrategia metodológica y de investigación contribuye a la reconstrucción del mismo.

  8. La cátedra abierta y permanente de Ética

    Directory of Open Access Journals (Sweden)

    Ana María Caballero

    2015-06-01

    Full Text Available La Cátedra Abierta y Permanente de Ética se propuso como un espacio de discusión y reflexión ético-política para debatir las diferentes corrientes del pensamiento axiológico y político, que propicie la resignificación de las representaciones culturales y sociales de sentido que permitan desarrollar una mirada socio histórica sobre las relaciones entre educación, ética y cultura colombiana, de tal manera que los estudiantes de la Universidad Pedagógica Nacional asuman una conciencia clara de su función como actores sociales en la construcción de la sociedad civil, la democracia, la promoción y la defensa de los derechos humanos, el crecimiento económico y el desarrollo social. La formación de valores morales que fundamenten una ética cívica parte del conocimiento de la realidad nacional y global, de la autoconciencia de cada individuo que aspira a constituirse en un ser autónomo usando su pensamiento crítico y participando en la construcción de la democracia, como modelo de gobierno que garantiza las libertades individuales, propiciando espacios para la conquista de los ideales de libertad, equidad, solidaridad y tolerancia, que permitan la convivencia ciudadana y la construcción de la nacionalidad colombiana.

  9. Estrategias del Teatro del Oprimido para la formación permanente del profesorado

    Directory of Open Access Journals (Sweden)

    Tomás Motos-Teruel

    2012-01-01

    Full Text Available Este artículo relata una experiencia y su valoración de formación permanente del profesorado basada en el aprendizaje vivencial utilizando como estrategia metodológica el Teatro del Oprimido (TO para estimular y favorecer la reflexión sobre la práctica educativa. Sus objetivos básicos fueron dar a conocer la formulación teórica y la metodología del TO y hacer la transferencia de las estrategias metodológicas vivenciadas a la práctica docente. El estudio se ha planteado desde una óptica cualitativa con el estudio de caso único. Y como resultados más destacables hay que reseñar el interés y la percepción de la utilidad personal y profesional del TO como instrumento de reflexión sobre la acción y generador de clima positivo. El Teatro del Oprimido es una formulación teórica y un método estético cuya teoría y praxis están inspiradas en la Pedagogía del Oprimido de Paulo Freire, utiliza las técnicas dramáticas como un instrumento eficaz para la comprensión y la búsqueda de alternativas a problemas sociales, interpersonales e individuales.

  10. Kaiser Permanente/Sandia National health care model. Phase I prototype final report. Part 1 - model overview

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, D.; Yoshimura, A.; Butler, D.; Judson, R. [and others

    1996-11-01

    This report describes the results of a Cooperative Research and Development Agreement between Sandia National Laboratories and Kaiser Permanente Southern California to develop a prototype computer model of Kaiser Permanente`s health care delivery system. As a discrete event simulation, SimHCO models for each of 100,000 patients the progression of disease, individual resource usage, and patient choices in a competitive environment. SimHCO is implemented in the object-oriented programming language C++, stressing reusable knowledge and reusable software components. The versioned implementation of SimHCO showed that the object-oriented framework allows the program to grow in complexity in an incremental way. Furthermore, timing calculations showed that SimHCO runs in a reasonable time on typical workstations, and that a second phase model will scale proportionally and run within the system constraints of contemporary computer technology. This report is published as two documents: Model Overview and Domain Analysis. A separate Kaiser-proprietary report contains the Disease and Health Care Organization Selection Models.

  11. The impact of removing financial incentives from clinical quality indicators: longitudinal analysis of four Kaiser Permanente indicators.

    Science.gov (United States)

    Lester, Helen; Schmittdiel, Julie; Selby, Joe; Fireman, Bruce; Campbell, Stephen; Lee, Janelle; Whippy, Alan; Madvig, Philip

    2010-05-11

    To evaluate the effect of financial incentives on four clinical quality indicators common to pay for performance plans in the United Kingdom and at Kaiser Permanente in California. Longitudinal analysis. 35 medical facilities of Kaiser Permanente Northern California, 1997-2007. 2 523 659 adult members of Kaiser Permanente Northern California. Main outcomes measures Yearly assessment of patient level glycaemic control (HbA(1c) financial incentives were attached to screening for diabetic retinopathy (1999-2003), the rate rose from 84.9% to 88.1%. This was followed by four years without incentives when the rate fell year on year to 80.5%. During the two initial years when financial incentives were attached to cervical cancer screening (1999-2000), the screening rate rose slightly, from 77.4% to 78.0%. During the next five years when financial incentives were removed, screening rates fell year on year to 74.3%. Incentives were then reattached for two years (2006-7) and screening rates began to increase. Across the 35 facilities, the removal of incentives was associated with a decrease in performance of about 3% per year on average for screening for diabetic retinopathy and about 1.6% per year for cervical cancer screening. Policy makers and clinicians should be aware that removing facility directed financial incentives from clinical indicators may mean that performance levels decline.

  12. Educação permanente: reflexão na prática da enfermagem hospitalar.

    Directory of Open Access Journals (Sweden)

    José Reginaldo PINTO

    2015-08-01

    Full Text Available Na prática hospitalar, a Educação Permanente é indispensável à formação dos trabalhadores, os quais necessitam ter conhecimentos renovados em sua prática profissional. Nesta perspectiva, buscou-se analisar por meio dessa pesquisa a percepção dos enfermeiros de um hospital de ensino acerca da educação permanente no ambiente hospitalar. Trata-se de uma pesquisa descritiva com abordagem qualitativa, realizada com nove enfermeiros coordenadores de setores, utilizando-se três grupos focais, constituído por três enfermeiros em cada grupo. A investigação ocorreu no Hospital do Coração do município de Sobral, Ceará. Utilizaram-se entrevistas que foram gravadas nas reuniões dos grupos. A análise de conteúdo de Bardin estruturou os achados encontrados. Esses resultados foram separados por unidades temáticas. Foram respeitados os princípios éticos de acordo com a resolução 466/12. A primeira unidade temática investigou o conhecimento dos sujeitos acerca da Educação Permanente, Continuada e em Serviço. Os primeiros achados identificaram divergências de opiniões dos participantes quando conceituaram a diferenciação entre as modalidades de educação em saúde. A segunda unidade resgatou a opinião dos sujeitos sobre as estratégias para implantar uma comissão de educação permanente no hospital. As falas dos participantes revelaram que a comissão deveria motivar os profissionais a continuarem se qualificando no serviço. Ainda indagaram que essas comissões deveria ter caráter multidisciplinar. A última unidade analisada referiu-se a forma de atuar das comissões de educação permanente. Os investigados assinalaram que elas deveriam proporcionar a melhoria do ensino aos profissionais aplicando as metodologias ativas.

  13. Photospheric Response to an Ellerman Bomb-like Event—An Analogy of Sunrise/IMaX Observations and MHD Simulations

    Energy Technology Data Exchange (ETDEWEB)

    Danilovic, S.; Solanki, S. K.; Barthol, P.; Gandorfer, A.; Gizon, L.; Hirzberger, J.; Riethmüller, T. L.; Van Noort, M. [Max-Planck-Institut für Sonnensystemforschung, Justus-von-Liebig-Weg 3, D-37077 Göttingen (Germany); Rodríguez, J. Blanco [Grupo de Astronomía y Ciencias del Espacio, Universidad de Valencia, E-46980 Paterna, Valencia (Spain); Del Toro Iniesta, J. C.; Suárez, D. Orozco [Instituto de Astrofísica de Andalucía (CSIC), Apartado de Correos 3004, E-18080 Granada (Spain); Schmidt, W. [Kiepenheuer-Institut für Sonnenphysik, Schöneckstr. 6, D-79104 Freiburg (Germany); Pillet, V. Martínez [National Solar Observatory, 3665 Discovery Drive, Boulder, CO 80303 (United States); Knölker, M., E-mail: danilovic@mps.mpg.de [High Altitude Observatory, National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307-3000 (United States)

    2017-03-01

    Ellerman Bombs are signatures of magnetic reconnection, which is an important physical process in the solar atmosphere. How and where they occur is a subject of debate. In this paper, we analyze Sunrise/IMaX data, along with 3D MHD simulations that aim to reproduce the exact scenario proposed for the formation of these features. Although the observed event seems to be more dynamic and violent than the simulated one, simulations clearly confirm the basic scenario for the production of EBs. The simulations also reveal the full complexity of the underlying process. The simulated observations show that the Fe i 525.02 nm line gives no information on the height where reconnection takes place. It can only give clues about the heating in the aftermath of the reconnection. However, the information on the magnetic field vector and velocity at this spatial resolution is extremely valuable because it shows what numerical models miss and how they can be improved.

  14. Métodos construtivos de pontes estaiadas - estudo da distribuição de forças nos estais.

    OpenAIRE

    María Fernanda Quintana Ytza

    2009-01-01

    As pontes estaiadas são pontes que consistem de um tabuleiro suportado por cabos retos e inclinados (estais) fixados nos mastros. Este tipo de estrutura é altamente hiperestática, bastante sensível à seqüência construtiva, mas mesmo assim aceitando, por conta a flexibilidade do tabuleiro uma considerável gama de esforços de instalação dos estais. É importante escolher uma distribuição inicial apropriada para esses esforços sob carregamento permanente tal que a flexão no tabuleiro seja limitad...

  15. A Internet que nos protege

    Directory of Open Access Journals (Sweden)

    Luana Negrelly Saraiva

    2001-02-01

    Full Text Available A partir de uma análise das relações interpessoais nos canais de chat, pretende-se mostrar a Internet como um espaço de proteção da mesma sociedade repressora que a criou, abrindo portas para o desenvolvimento e o resgate dos valores humanos.

  16. TENDENCIATEMPORALDE LAINCAPACIDAD LABORAL PERMANENTE EN ESPAÑA (1992-2010

    Directory of Open Access Journals (Sweden)

    Xavier Duran

    2012-01-01

    Full Text Available Fundamentos: La incapacidad permanente (IP es un problema de salud laboral en el que intervienen factores laborales, sanitarios o legales, los cuales han variado en España a lo largo de los últimos años. El objetivo del presente estudio es describir la tendencia temporal de la IP en España desde 1992 a 2010 por gravedad de la incapacidad y diferentes variables sociodemográficas y de afiliación a la seguridad social. Métodos: A partir de los datos de la Seguridad Social sobre afiliación y altas de IP en España se describió la tendencia temporal de la incidencia anual de la IP en el periodo comprendido entre 1992 y 2010. Para valorar las tendencias se estimó el porcentaje de cambio anual (PCA y el intervalo de confianza al 95% mediante un modelo de regresión binomial negativa. Resultados: La tendencia de la incidencia de IP se subdividió en tres periodos. El primero (1992 a 1997 presentó una incidencia aproximadamente constante de 75 casos por 10.000 trabajadores (PCA1= -0,1; IC 95%:-1,6 a 1,4. Seguidamente las tasas descendieron durante un período de tres años (PCA2:-12,1%; IC 95%:-13,9 a -10,4, situándose alrededor de 50 nuevos casos por 10.000 trabajadores en el año 2000. A partir de este año la incidencia de IP se mantuvo aproximadamente constante hasta el año 2010 (PCA3=0,4; IC 95%:-0,2 a 1,0. Conclusiones: Apesar del incremento de trabajadores afiliados a la seguridad social en el periodo estudiado, la incidencia de IP se mantiene bastante estable, con un descenso entre 1997 y 2000 que se podría atribuir a las medidas de evaluación y seguimiento de las IP adoptados en 1995.

  17. A Community-Level Initiative to Prevent Obesity: Results From Kaiser Permanente's Healthy Eating Active Living Zones Initiative in California.

    Science.gov (United States)

    Cheadle, Allen; Atiedu, Akpene; Rauzon, Suzanne; Schwartz, Pamela M; Keene, Laura; Davoudi, Mehrnaz; Spring, Rebecca; Molina, Michelle; Lee, Lynda; Boyle, Kathryn; Williamson, Dana; Steimberg, Clara; Tinajero, Roberta; Ravel, Jodi; Nudelman, Jean; Azuma, Andrea Misako; Kuo, Elena S; Solomon, Loel

    2018-05-01

    A growing number of health systems are leading health promotion efforts in their wider communities. What impact are these efforts having on health behaviors and ultimately health status? This paper presents evaluation results from the place-based Kaiser Permanente Healthy Eating Active Living Zones obesity prevention initiative, implemented in 2011-2015 in 12 low-income communities in Kaiser Permanente's Northern and Southern California Regions. The Healthy Eating Active Living Zones design targeted places and people through policy, environmental, and programmatic strategies. Each Healthy Eating Active Living Zone is a small, low-income community of 10,000 to 20,000 residents with high obesity rates and other health disparities. Community coalitions planned and implemented strategies in each community. A population-dose approach and pre and post surveys were used to assess impact of policy, program, and environmental change strategies; the analysis was conducted in 2016. Population dose is the product of reach (number of people affected by a strategy divided by target population size) and strength (the effect size or relative change in behavior for each person exposed to the strategy). More than 230 community change strategies were implemented over 3 years, encompassing policy, environmental, and programmatic changes as well as efforts to build community capacity to sustain strategies and make changes in the future. Positive population-level results were seen for higher-dose strategies, particularly those targeting youth physical activity. Higher-dose strategies were more likely to be found in communities with the longest duration of investment. These results demonstrate that strong (high-dose), community-based obesity prevention strategies can lead to improved health behaviors, particularly among youth in school settings. This article is part of a supplement entitled Building Thriving Communities Through Comprehensive Community Health Initiatives, which is

  18. EDUCAÇÃO PERMANENTE NO CONTEXTO HOSPITALAR: A EXPERIÊNCIA QUE RESSIGNIFICA O CUIDADO EM ENFERMAGEM

    OpenAIRE

    Flores,Giovana Ely; Oliveira,Dora Lúcia Leidens de; Zocche,Denise Antunes de Azambuja

    2016-01-01

    Resumo O artigo aborda o processo de formação vivenciado por enfermeiras educadoras no contexto hospitalar, na perspectiva da educação permanente em saúde, com destaques para as experiências que constituíram esse processo, os sentidos dessa formação e as mudanças decorridas no desenvolvimento do cuidado de enfermagem com base nas aprendizagens significativas. Tratou-se de estudo qualitativo exploratório-descritivo, desenvolvido por meio de grupos focais com sete enfermeiras que atuavam no Pro...

  19. Ätiologie und Prävalenz permanenter kindlicher Hörstörungen in Deutschland

    OpenAIRE

    Spormann-Lagodzinski, ME; Nubel, K; König, O; Gross, M; Gross, M

    2003-01-01

    Permanente Hörstörungen bei Kindern haben in den letzten Jahren bezüglich Ätiologie und Prävalenz einen deutlichen Wandel erlebt. In den westlichen Industrienationen ist sie auf 1 bis 3 pro 1.000 Neugeborene gesunken. Nach Ergebnissen des Deutschen Zentralregisters für kindliche Hörstörungen (DZH) liegt die Prävalenz in Deutschland bei ca. 1,2:1.000. Von 6.200 ausgewerteten Datensätzen des DZH haben 36% aller permanenten Hörstörungen eine (vermutlich oder gesichert) genetische Ursache, 18% si...

  20. Minería de datos en la encuesta permanente de hogares 2009, universidad nacional del litoral, argentina

    OpenAIRE

    Denis Lizazo Torres; Roberto Delfor Meyer; Verena Torres Cárdenas

    2011-01-01

    En este trabajo se aplicó por primera vez la Minería de Datos a la información generada por la Encuesta Permanente de Hogares del año 2009, del Observatorio Social de la Universi-dad del Litoral en Santa Fe, Argentina. El objetivo fue utilizar algoritmos de clasificación que poseen enfoques descriptivos, y es una de las tareas más utilizada en Minería de Datos para obtener nuevos conocimientos sobre la familia santafecina. La base de datos fue confeccio-nada con la información en el relevamie...

  1. Las ciencias naturales me generan... emociones vinculadas a las ciencias en la formación docente permanente

    OpenAIRE

    Mengascini, Adriana

    2017-01-01

    Presentamos y discutimos resultados de una indagación realizada en el contexto de una propuesta de formación docente permanente, respecto de las emociones asociadas a las ciencias naturales, a su enseñanza y a la realización de trabajos experimentales entre docentes de primaria y secundaria de Argentina. Las emociones manifestadas hacia las ciencias fueron positivas (interés, atracción, motivación), aunque respecto de su enseñanza y la realización de actividades experimentales se expresaron a...

  2. Educação permanente de docentes: análise crítica de experiências não sistematizadas

    Directory of Open Access Journals (Sweden)

    Henriqueta Galvanin Guidio de Almeida

    Full Text Available Quando alterações curriculares abrangentes são propostas para os cursos de Medicina, como no caso da implantação de um currículo integrado, exige-se do professor a modificação de seu papel central de transmissor de conhecimentos para um papel mais cooperativo efacilitador do processo de ensino-aprendizagem, o que pode gerar insegurança, sensação de perda de poder e resistência. A capacitação formal dos docentes para suas novas funções é imperiosa para o sucesso nas mudanças. Além das ações educativas sistematizadas, atividades alternativas podem contribuir para aperfeiçoar a função docente. Este artigo analisa a experiência de docentes do curso de Medicina da Universidade Estadual de Londrina (UEL, membros das comissões de apoio ao colegiado, que desenvolveram, nos primeiros anos da implantação do currículo integrado, atividades não sistematizadas de educação permanente junto a docentes do curso. São comentadas informações a respeito: da reunião semanal realizada com os tutores; da pesquisação sobre a inserção e o desenvolvimento docente no currículo integrado; da revisão dos conteúdos dos módulos temáticos; da pesquisação com os coordenadores dos módulos temáticos; e do inquérito realizado com os preceptores de áreas do internato médico. As atividades analisadas forneceram respostas a demandas locais e contribuíram com a dinâmica de um processo de implantação que deve permanecer em contínua renovação.

  3. Evaluación de la formación permanente del profesorado: enfoque de resultados || Evaluation of permanent teacher training: approach of results

    Directory of Open Access Journals (Sweden)

    José Domínguez

    2015-07-01

    Full Text Available La evolución del sistema educativo ha provocado cambios significativos en la formación permanente del profesorado, por tanto, es necesario un diagnóstico de necesidades utilizando instrumentos y metodologías que informen de las demandas formativas profesionales. En este sentido, el objetivo principal del estudio se centra en aportar luz sobre las percepciones y expectativas del profesorado acerca de la formación permanente en la Comunidad Autónoma de Galicia. Para ello, se utilizó una metodología evaluativa centrada en el contexto, entrada, proceso y producto (diseño CIPP. Los resultados confirman que la evolución de la formación se viene incrementando en su oferta pero disminuyendo su eficacia. Además, se ha comprobado la necesidad de reestructurar la formación permanente, apostando por un modelo más global, con cobertura en todas las necesidades formativas del profesorado. El gran reto de la formación permanente del profesorado es la transferibilidad de la misma al contexto del aula, una cuestión sencilla pero muy difícil de evaluar. Mejorar la calidad educativa depende directamente de la eficiencia y excelencia en la formación docente, la cual debería someterse a un proceso de revisión y actualización permanente.

  4. Control permanente de la gestión sanitaria por monitoreo de costos mediante acontecimientos indicadores

    Directory of Open Access Journals (Sweden)

    Horacio Villanueva

    2001-12-01

    Full Text Available Objetivos. Determinar el costo operacional de un servicio quirúrgico, comparar los resultados con estándares y determinar la incidencia de costos. Obtener una metodología eficaz para este fin, extrapolable a todo tipo de servicio asistencial y de fácil instrumentación en una herramienta informática convencional (base de datos de alta difusión y bajo costo que pueda usarse en el control permanente de la gestión. Métodos. El estudio se realizó durante 1999 en el Servicio de Ortopedia y Traumatología del Hospital Estatal "Domingo Funes", Córdoba, Argentina. De los 817 pacientes sometidos a procedimientos diagnósticos o terapéuticos en ese servicio a lo largo del año, se seleccionaron los 154 que necesitaron internación y maniobras quirúrgicas o instrumentales. Se utilizó el método de acontecimientos indicadores descrito por Kessner. Dichos acontecimientos, clasificados en función de su complejidad (alta, mediana, escasa o nula, fueron seleccionados y definidos por consenso de expertos: especialistas médicos y economistas. Se valoraron los costos directos e indirectos para estudiar su peso en el costo total, en cuya estimación se utilizaron nueve variables que se aplicaron a los diferentes acontecimientos indicadores. Resultados. El mayor peso del costo total, tanto estándar como real, recayó en ambos casos sobre la variable "día cama". De la variable "día cama" en el total de acontecimientos indicadores, el 51,2% correspondió a la internación social (costo indirecto y el 48,8% a la internación terapéutica (costo directo. Su diferencia con respecto al costo estándar fue un aumento del orden del 117%. Los costos indirectos (internación social e insumos terapéuticos absorbieron casi la mitad del costo real total. El costo real de todos los acontecimientos investigados, sin incluir los costos indirectos, solo superó al costo estándar en un 6,4%. Incluyendo los costos indirectos (internación social e insumos terap

  5. A epilepsia nos tumores cerebrais

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    Luís Marques-Assis

    1969-03-01

    Full Text Available De 411 casos de tumores cerebrais foram estudados 86 (19,4% que apresentaram manifestações epilépticas. A epilepsia foi estudada quanto à duração, ao tipo de manifestação e à severidade, em relação à natureza e à localização dos tumores cerebrais. A análise dos resultados permitiu aos autores chegarem às seguintes conclusões: 1 a epilepsia incidiu em 19,4% dos casos; 2 o oligodendroglioma, as metástases carcinomatosas e o glioblastoma multiforme foram, pela ordem, os tumores mais epileptogênicos; 3 as áreas frontal, parietal e temporal foram, nessa ordem, as localizações mais epileptogênicas; 4 os carcinomas metastáticos predominaram nos casos com epilepsia com menos de um ano de evolução, enquanto que os astrocitomas predominaram nos casos com mais de três anos; quanto à topografia, predominou a região frontal no primeiro grupo e a temporal, no segundo; 5 nas formas mais severas de epilepsia predominaram os oligodendrogliomas e os meningeomas, quanto à natureza, e a região frontotemporal e a foice, quanto à localização; 6 os craniofaringeomas e os meduloblastomas foram os tumores que mais freqüentemente determinaram o aparecimento de convulsões puras; nesses casos, a sela túrsica e a fossa posterior foram as sedes mais freqüentes; 7 os carcinomas metastáticos e os meningeomas, quanto à natureza, e as regiões frontoparietal e parietal, quanto à localização, foram os mais freqüentemente encontrados nos casos com crises de tipo bravais-jacksoniano.

  6. Formación permanente y distribución del profesorado de Educación Secundaria por comarcas y departamentos. El caso de Asturias

    OpenAIRE

    Paula GONZÁLEZ-VALLINAS; José Luis SAN FABIÁN MAROTO

    2009-01-01

    Este estudio se centra en la formación del profesorado y explora las relaciones existentes entre la formación permanente y diversas características del profesorado, las comarcas y departamentos de los IES en Asturias. Como resultado de una investigación basada en el análisis de datos secundarios cuantitativos del profesorado y municipios de Asturias se obtiene una radiografía de la formación permanente de su profesorado (modalidad y materia de formación). Se realizan análisis a nivel de depar...

  7. Desvelamento crítico da pessoa estomizada: em ação o programa de educação permanente em saúde Develamiento crítico de la persona ostomizada: programa de educación permanente en salud en acción Critical unveiling of people with stomas: the continuing health education program in action

    Directory of Open Access Journals (Sweden)

    Regina Ribeiro Cunha

    2012-01-01

    Full Text Available OBJETIVO: Apresentar o desvelamento crítico do Itinerário de Pesquisa Freireano na atenção à pessoa estomizada. MÉTODOS: Estudo qualitativo em saúde articulado com o referencial metodológico de Freire, que compreende a obtenção e análise dos dados nos círculos dialógicos, constituído por três momentos dialéticos, interdisciplinarmente entrelaçados: investigação temática, codificação e descodificação e desvelamento crítico. Ocorreu no período de abril de 2009 e fevereiro de 2010, com número irregular de participantes, no auditório da Unidade de Referência Especializada Presidente Vargas, no Município de Belém/PA. RESULTADOS: A deficiente qualificação dos profissionais de saúde foi um dos temas geradores mais relevantes, sendo desvelada a necessidade de implantação de um Programa de Educação Permanente na Atenção à pessoa estomizada. CONCLUSÃO: O desvelamento proposto constituiu uma vivência para que essas pessoas estomizadas habilitem-se a "ler o mundo" e, assim, conheçam e caminhem rumo à transformação de sua realidade.OBJETIVO: Presentar el develamiento crítico del Itinerario de Investigación Freireano en la atención a la persona ostomizada. MÉTODOS: Estudio cualitativo en salud articulado con el referencial metodológico de Freire, que comprende la obtención y análisis de los datos en los círculos dialógicos, constituido por tres momentos dialécticos, interdisciplinariamente entrelazados: investigación temática, codificación y decodificación y develamiento crítico. Se llevó a cabo en el período de abril del 2009 y febrero del 2010, con un número irregular de participantes, en el auditorio de la Unidad de Referencia Especializada Presidente Vargas, en el Municipio de Belém/PA. RESULTADOS: La deficiente calificación de los profesionales de salud fue uno de los temas generadores más relevantes, siendo develada la necesidad de implantación de un Programa de Educación Permanente

  8. Un estudio de las concepciones docentes acerca de la formación permanente Um estudo das concepções docentes sobre a formação permanente A Survey of Teachers' Thoughts on Continuing Education

    Directory of Open Access Journals (Sweden)

    Irene Marina Macera

    2012-12-01

    Full Text Available Este trabajo presenta las concepciones docentes acerca de su formación permanente. Se identificaron distintos puntos de análisis relacionados con la antigüedad en la profesión, intereses metodológicos, intereses de actualización de conocimientos, intereses de incorporación de nuevos saberes y, por último, el lugar que ocupa la formación en la subjetividad docente. En los inicios de la docencia, la formación permanente funciona y se concibe como un modo de mantenerse activos mientras se insertan en el mercado laboral. En cambio, para los docentes que ya tienen una trayectoria, esta se concibe como una fuga del trabajo, un recurso que en ocasiones le otorga sentido al trabajo, asumiendo de este modo un lugar subjetivo importante en el quehacer docente. Pero, cualquiera que sea la motivación, la adquisición de nuevos saberes es la razón más antigua que los docentes asumen para formarse.Este trabalho apresenta as concepções docentes sobre sua formação permanente. Identificaram-se diferentes pontos de análise relacionados com a antiguidade na profissão, interesses metodológicos, interesses de atualização de conhecimentos, interesses de incorporação de novos saberes e, por último, o lugar que a formação ocupa na subjetividade docente. No início da docência, a formação permanente funciona e se concebe como um modo de se manterem ativos enquanto se inserem no mercado de trabalho. Em compensação, para os docentes que já têm uma trajetória, esta se concebe como uma fuga do trabalho, um recurso que em ocasiões outorga sentido ao trabalho e assume, desse modo, um lugar subjetivo importante no fazer docente. Contudo, qualquer que seja a motivação, a aquisição de novos saberes é a razão mais antiga que os docentes assumem para se formar.This study delves into what teachers think about their own continuing education. Different points of analysis are identified with respect to seniority in the profession

  9. Gestión de la formación permanente del docente: reflexión y propuesta

    Directory of Open Access Journals (Sweden)

    MSc. Silvia M. Sarmiento-Berrezueta

    2015-11-01

    Full Text Available La práctica educativa actual exige implementar un nuevo Modelode Gestión de la formación permanente de los docentes basado en los estándares de calidad. Este artículo se centra en cómo alcanzar la calidad de la gestión formativa profesional mediante una propuesta de autoformación y co-formación basada sobre la reflexión, valoración y motivación, normada desde el Código de Convivencia, que conlleva a aprender y desaprender en los colectivos de docentes de educación básica superior en el Ecuador.

  10. Inmunización y militarización del cuerpo social en Colombia: el Estado en emergencia permanente

    Directory of Open Access Journals (Sweden)

    Juan Pablo Aranguren Romero

    2015-12-01

    Full Text Available En este artículo analizo cómo las estrategias de guerra contrainsurgente emprendidas en Colombia durante las décadas de los sesenta y los setenta recrean un dispositivo inmunitario en donde la nación es entendida como un cuerpo social amenazado e infectado por ideologías comunistas y en donde su seguridad y protección contra los actos violentos, suponen la administración de la violencia. Sostengo que este dispositivo inmunitario, opera bajo una lógica autodestructiva y una noción de amenaza deslocalizada que incentivó la militarización de la sociedad, la gestión del miedo y el sostenimiento de un Estado en emergencia permanente. Hechos que, a su vez, permitieron la apelación a la excepcionalidad constitucional como forma de gobierno normalizada.

  11. MERCOSUR ambiental. El aporte del Laudo 1/2012 del Tribunal Permanente de Revisión

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    Alberto Cesar Moreira

    2014-03-01

    Full Text Available El trabajo reflexiona acerca de la dimensión ambiental del MERCOSUR, identificando los desarrollos institucionales y normativos más significativos e intentando desentrañar algunas de las causas que dificultan su consolidación. En ese orden de ideas, destaca la escasa utilización que los Estados han hecho del sistema de solución de controversias de este esquema y pone de resalto el aporte del laudo 1/2012 del Tribunal Permanente de Revisión, ya que al resolver sobre su competencia en razón de la materia, reconoce y acompaña a las distintas dimensiones que el MERCOSUR ha ido desarrollado, entre ellas la ambiental.

  12. COMPETENCIAS EMPRENDEDORAS DEL ALUMNADO DE EDUCACIÓN PERMANENTE DE ADULTOS EN ANDALUCÍA. PERCEPCIÓN DEL PROFESORADO

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    José Ma. Fernández Batanero

    2017-01-01

    Full Text Available En el presente trabajo analizamos la percepción que tiene el profesorado de Educación Permanente de Personas Adultas en Andalucía (España acerca del grado de presencia de competencias emprendedoras en su alumnado. Para dar respuesta al objetivo planteado adoptamos un diseño de investigación de tipo descriptivo, donde el enfoque de recolección y análisis de datos se ha definido como mixto, en el que se integran técnicas cualitativas (entrevistas en profundidad y cuantitativas (cuestionario. Para la validación del cuestionario, se utilizó la técnica de juicio de expertos, seleccionados mediante el procedimiento de «Coeficiente de competencia experta» o «Coeficiente K». El análisis de la fiabilidad del cuestionario a través de la prueba de Cronbach fue de 0,957. El cuestionario ha sido respondido por 549 profesores y profesoras de Centros de Educación Permanente de Andalucía y se han realizado 23 entrevistas en profundidad a informantes claves (directores de centros y coordinadores de sección. Los resultados muestran con claridad la percepción, tanto del profesorado como de aquellos que ejercen el ejercicio de la dirección, que el alumnado de estos centros educativos no están lo suficientemente preparados para iniciar por su cuenta un proyecto empresarial, a pesar de cursar contenidos curriculares de cultura emprendedora. Consideran que aún no poseen las competencias emprendedoras necesarias para crear y gestionar eficazmente un proyecto empresarial, constituyendo la falta de creatividad uno de los mayores obstáculos para dicho fin. Así mismo, se desprende del estudio la escasa incidencia que ejercen los programas de cultura emprendedora que se desarrollan en este tipo de centros.

  13. Kaiser Permanente Creatinine Safety Program: A Mechanism to Ensure Widespread Detection and Care for Chronic Kidney Disease.

    Science.gov (United States)

    Sim, John J; Rutkowski, Mark P; Selevan, David C; Batech, Michael; Timmins, Royann; Slezak, Jeff M; Jacobsen, Steven J; Kanter, Michael H

    2015-11-01

    Chronic kidney disease is highly prevalent but is challenging to diagnose because of the need to establish chronicity. Within the current healthcare environment, a single abnormal creatinine measurement often can go without a follow-up, which can lead to missed diagnoses or diagnostic errors. The Kaiser Permanente Southern California creatinine safety program (the Creatinine SureNet) was created to help ensure that all single abnormal creatinine results had a follow-up evaluation. In the period February 1, 2010, to March 1, 2014, the electronic health records were used to capture individuals with single abnormal creatinine results that went >90 days without a repeat measurement. A coordinated effort among a centralized regional nurse and providers was used to communicate with patients and order a repeat creatinine measurement. A total of 12,396 individuals were identified (84% ambulatory care encounters). A total of 6981 individuals (52%) followed up with a repeat measurement. Female patients, non-Hispanic whites, and older individuals were more likely to obtain a repeat measurement. Subsequently, 3668 individuals had chronic kidney disease confirmed. Within 6 months, 1550 patients had chart documentation of their chronic kidney disease and 336 patients had a nephrology consultation. The ambulatory care environment, given its high volume and various prioritizations, is an under-recognized area where diagnostic errors are not uncommon and failure to follow up on abnormal test results can occur routinely. The Kaiser Permanente Southern California Creatinine SureNet program leverages the electronic health records and its multidisciplinary resources in an effort to ensure that patients with potential chronic kidney disease are identified and managed properly. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. MGE-derived nNOS+ interneurons promote fear acquisition in nNOS-/- mice.

    Science.gov (United States)

    Zhang, Lin; Yuan, Hong-Jin; Cao, Bo; Kong, Cheng-Cheng; Yuan, Fang; Li, Jun; Ni, Huan-Yu; Wu, Hai-Yin; Chang, Lei; Liu, Yan; Luo, Chun-Xia

    2017-12-02

    Neuronal nitric oxide synthase (nNOS) 1 , mainly responsible for NO release in central nervous system (CNS) 2 , plays a significant role in multiple physiological functions. However, the function of nNOS + interneurons in fear learning has not been much explored. Here we focused on the medial ganglionic eminences (MGE) 3 -derived nNOS + interneurons in fear learning. To determine the origin of nNOS + interneurons, we cultured neurons in vitro from MGE, cortex, lateral ganglionic eminence (LGE) 4 , caudal ganglionic eminences (CGE) 5 and preoptic area (POA) 6 . The results showed that MGE contained the most abundant precursors of nNOS + interneurons. Moreover, donor cells from E12.5 embryos demonstrated the highest positive rate of nNOS + interneurons compared with other embryonic periods (E11.5, E12, E13, E13.5 and E14). Additionally, these cells from E12.5 embryos showed long axonal and abundant dendritic arbors after 10 days culture, indicating the capability to disperse and integrate in host neural circuits after transplantation. To investigate the role of MGE-derived nNOS + interneurons in fear learning, donor MGE cells were transplanted into dentate gyrus (DG) 7 of nNOS knock-out (nNOS -/- ) or wild-type mice. Results showed that the transplantation of MGE cells promoted the acquisition of nNOS -/- but not the wild-type mice, suggesting the importance of nNOS + neurons in fear acquisition. Moreover, we transplanted MGE cells from nNOS -/- mice or wild-type mice into DG of the nNOS -/- mice and found that only MGE cells from wild-type mice but not the nNOS -/- mice rescued the deficit in acquisition of the nNOS -/- mice, further confirming the positive role of nNOS + neurons in fear learning. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Neuronal NOS localises to human airway cilia.

    Science.gov (United States)

    Jackson, Claire L; Lucas, Jane S; Walker, Woolf T; Owen, Holly; Premadeva, Irnthu; Lackie, Peter M

    2015-01-30

    Airway NO synthase (NOS) isoenzymes are responsible for rapid and localised nitric oxide (NO) production and are expressed in airway epithelium. We sought to determine the localisation of neuronal NOS (nNOS) in airway epithelium due to the paucity of evidence. Sections of healthy human bronchial tissue in glycol methacrylate resin and human nasal polyps in paraffin wax were immunohistochemically labelled and reproducibly demonstrated nNOS immunoreactivity, particularly at the proximal portion of cilia; this immunoreactivity was blocked by a specific nNOS peptide fragment. Healthy human epithelial cells differentiated at an air-liquid interface (ALI) confirmed the presence of all three NOS isoenzymes by immunofluorescence labelling. Only nNOS immunoreactivity was specific to the ciliary axonemeand co-localised with the cilia marker β-tubulin in the proximal part of the ciliary axoneme. We report a novel localisation of nNOS at the proximal portion of cilia in airway epithelium and conclude that its independent and local regulation of NO levels is crucial for normal cilia function. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. Caries dental aguda del primer molar permanente en niños de 12 años

    Directory of Open Access Journals (Sweden)

    Daniel Enrique Reyes Romagosa

    Full Text Available Introducción: el primer molar permanente es considerado la llave de la oclusión dentaria, la presencia de caries en éste es elevada, lo que dificulta el logro de las metas trazadas por organizaciones de salud a nivel mundial en este grupo de edad. Objetivo: determinar el comportamiento de la caries dental aguda en primer molar permanente en una población de 12 años de edad atendida en la Clínica Estomatológica Santa Cruz de la Parroquia Goaigoaza. Métodos: se realizó un estudio descriptivo transversal en la Clínica Estomatológica Santa Cruz. Parroquia Goaigoaza, municipio Puerto Cabello, estado Carabobo, en el período comprendido entre abril del 2009 a abril 2010. Se seleccionaron 97 pacientes de 12 años de edad los que constituyeron el universo y la muestra. Acudieron a la consulta por dolor debido a la presencia de caries dental aguda. Se registraron las variables: edad, sexo, grado clínico de la caries dental, estímulos externos que provocaron dolor, la cara dental y la arcada dentaria más afectadas. La información fue recogida mediante interrogatorio y examen clínico. Resultados: el sexo masculino representó el 63,9 %. La caries dental de 3er grado estuvo presente en un 68 %. Los estímulos externos que provocaron dolor fueron: el frío presente en 75,2 % y los alimentos dulces en 69,1 % en ambos sexos. El primer molar inferior derecho resultó más afectado (46,4 % que el izquierdo (36,1 %, así como la arcada dentaria inferior (25,8 % y la cara oclusal (64,9 %. Conclusiones: predominaron el sexo masculino y la caries dental aguda de 3er grado. El frío y los alimentos dulces fueron los estímulos externos más frecuentes. Los más afectados resultaron el primer molar inferior derecho, la cara oclusal y la arcada dentaria inferior.

  17. The organizational dynamics enabling patient portal impacts upon organizational performance and patient health: a qualitative study of Kaiser Permanente.

    Science.gov (United States)

    Otte-Trojel, Terese; Rundall, Thomas G; de Bont, Antoinette; van de Klundert, Joris; Reed, Mary E

    2015-12-16

    Patient portals may lead to enhanced disease management, health plan retention, changes in channel utilization, and lower environmental waste. However, despite growing research on patient portals and their effects, our understanding of the organizational dynamics that explain how effects come about is limited. This paper uses qualitative methods to advance our understanding of the organizational dynamics that influence the impact of a patient portal on organizational performance and patient health. The study setting is Kaiser Permanente, the world's largest not-for-profit integrated delivery system, which has been using a portal for over ten years. We interviewed eighteen physician leaders and executives particularly knowledgeable about the portal to learn about how they believe the patient portal works and what organizational factors affect its workings. Our analytical framework centered on two research questions. (1) How does the patient portal impact care delivery to produce the documented effects?; and (2) What are the important organizational factors that influence the patient portal's development? We identify five ways in which the patient portal may impact care delivery to produce reported effects. First, the portal's ability to ease access to services improves some patients' satisfaction as well as changes the way patients seek care. Second, the transparency and activation of information enable some patients to better manage their care. Third, care management may also be improved through augmented patient-physician interaction. This augmented interaction may also increase the 'stickiness' of some patients to their providers. Forth, a similar effect may be triggered by a closer connection between Kaiser Permanente and patients, which may reduce the likelihood that patients will switch health plans. Finally, the portal may induce efficiencies in physician workflow and administrative tasks, stimulating certain operational savings and deeper involvement of

  18. Minería de datos en la encuesta permanente de hogares 2009, universidad nacional del litoral, argentina

    Directory of Open Access Journals (Sweden)

    Denis Lizazo Torres

    2011-04-01

    Full Text Available En este trabajo se aplicó por primera vez la Minería de Datos a la información generada por la Encuesta Permanente de Hogares del año 2009, del Observatorio Social de la Universi-dad del Litoral en Santa Fe, Argentina. El objetivo fue utilizar algoritmos de clasificación que poseen enfoques descriptivos, y es una de las tareas más utilizada en Minería de Datos para obtener nuevos conocimientos sobre la familia santafecina. La base de datos fue confeccio-nada con la información en el relevamiento de 2009, denominado Onda 2009, y se procesó con el software de minería de datos Weka 3.6.2. Los algoritmos de clasificación que mejores resultados aportaron fueron: ZeroR, Ridor y J48, pertenecientes a los grupos de Reglas y Árboles de Decisión, siendo el algoritmo de clasificación J48 el que mejor clasifica a la En-cuesta Permanente de Hogares 2009 del Observatorio Social de la Universidad Nacional del Litoral. In this work it was applied the Data Mining for the first time, to the information generated by the Permanent Survey of Homes of the year 2009, of the Social Observatory of the University of the Litoral in Santa Fe, Argentina. The objective was to use classification algorithms that possess descriptive focuses and it is one of the tasks more used in Data Mining, to obtain new knowledge on the family of Santa Fe. The database was made with the information of the Permanent Survey of Homes of the year 2009 and it was processed with the software of data mining Weka 3.6.2. The classification algorithms that better results contributed were: ZeroR, Ridor and J48, belonging to the groups of Rules and Trees of Decision, being the classifica-tion algorithm J48 the one that better it classifies to the Permanent Survey of Homes 2009, of the Social Observatory of the National University of the Litoral.

  19. Modelagem da vida de fadiga e do acúmulo de deformações permanentes em pavimentos asfálticos por meio de um modelo de dano contínuo

    Directory of Open Access Journals (Sweden)

    Victor Ferreira Teixeira

    2009-10-01

    Full Text Available

    É sabido que as condições das rodovias brasileiras têm grande impacto sobre a economia nacional. Diante disso, nasce a necessidade de uma busca por métodos de análise de pavimentos que possam prever com maior precisão as falhas as quais o pavimento está submetido. Dentre os principais métodos utilizados atualmente, pode-se citar os métodos puramente empíricos e aqueles mecanístico-empíricos que fazem uso da resposta estrutural do pavimento. A aprimoração de técnicas numéricas como o Método dos Elementos Finitos (MEF ou o Método dos Elementos de Contorno (MEC tem feito com que os métodos mecanístico-empíricos ganhem cada vez mais espaço e sejam mais usados no dimensionamento de pavimentos. O presente trabalho apresenta um modelo mecanístico que considera a evolução do dano causado pelos carregamentos e, conseqüentemente, possibilita uma melhor simulação da vida de fadiga da camada asfáltica. O modelo também possibilita uma melhor modelagem do acúmulo de deformação permanente nos pavimentos através do uso da Teoria da Viscoelasticidade, permitindo assim avaliar as duas principais falhas dos pavimentos flexíveis.

  20. Valoración "in vitro" de las fuerzas de adhesión de un sistema adhesivo convencional y otro autograbante en esmalte de dientes temporales y permanentes

    OpenAIRE

    Herrera Martínez, Gilberto de Jesús

    2012-01-01

    El presente trabajo trata de aportar más información sobre un nuevo adhesivo autograbante a esmalte de dientes temporales y permanentes. El objetivo es valorar las fuerzas de adhesión en MPa de los sistemas adhesivos (convencional y autograbante),en el esmalte de dientes temporales y permanentes. Métodos: utilizando una muestra de 160 dientes (temporales y permanentes)a nivel de la estructura del esmalte, divididos en cuatro grupos, no tomándose en cuenta para el criterio de selección la p...

  1. Historias de vida de mujeres afincadas de forma permanente en situación de exclusión social

    Directory of Open Access Journals (Sweden)

    Gabriela Moriana Mateo

    2016-07-01

    Full Text Available Este artículo presenta parte de los resultados de un trabajo de campo etnográfico realizado en distintos centros de Servicios Sociales Especializados para mujeres de la Generalitat Valenciana. Su objetivo es conocer los tipos de violencia y los factores de exclusión social que subyacen en las historias de vida de las mujeres institucionalizadas. La metodología de investigación utilizada ha sido de índole cualitativa. Se ha realizado observación participante y entrevistas tanto informales como biográficas que, junto con documentos personales e informes sociales, han permitido elaborar 15 historias de vida. Aunque en esta aproximación tan sólo se analizan las cuatro afincadas en la situación de exclusión social de forma permanente. Respecto a los resultados, cabe señalar que en las trayectorias vitales analizadas subyacen distintos factores de exclusión social que afectan tanto a los hombres como a las mujeres, pero también importantes factores específicos de género, como la violencia contra las mujeres intrafamiliar y de género.

  2. Educação permanente: uma ferramenta para o desenvolvimento docente na graduação

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Lazarini

    Full Text Available OBJETIVO: Descrever a percepção dos docentes tutores e dos docentes da Unidade de Prática Profissional (UPP da primeira série dos cursos de Medicina e Enfermagem da Famema quanto à relevância de participar do programa de Educação Permanente (EP. MÉTODOS: Estudo exploratório com questionário semiestruturado. Empregou-se a técnica de análise temática do Discurso do Sujeito Coletivo. RESULTADOS: A quase totalidade dos sujeitos considerou a atividade de EP como relevante. Os docentes da UPP apontaram ótimo espaço para aprendizagem, troca de experiências e reflexão sobre a prática. As ideias centrais dos tutores foram bom espaço de discussão e reflexão, porém um momento mal aproveitado. CONSIDERAÇÕES: Para os docentes da UPP, a proposta da EP (reflexão sobre a prática vem sendo atingida, mas não tem respondido às expectativas e ao entendimento dos tutores. Dada a importância do desenvolvimento docente para a sustentação de um currículo inovador, é necessário problematizar os sentidos implícitos nesta fala em busca de uma EP mais responsiva aos tutores

  3. NOAA NOS SOS, EXPERIMENTAL, 1902-present, Salinity

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have salinity data. *These services are for testing and evaluation use...

  4. NOAA NOS SOS, EXPERIMENTAL, 1902-present, Conductivity

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have conductivity data. *These services are for testing and evaluation use...

  5. Educação permanente em saúde e no trabalho de enfermagem: perspectiva de uma práxis transformadora.

    OpenAIRE

    da Silva, Luiz Anildo Anacleto; Centro de Educação Superior Norte da Universidade Federal de Santa Maria; Ferraz, Fabiane; Universidade Federal de Santa Catarina; Lino, Mônica Motta; Universidade Federal de Santa Catarina; Backes, Vânia Marli Schubert; Universidade Federal de Santa Catarina; Schmidt, Sandra Marcia Soares; Universidade Federal de Santa Maria

    2011-01-01

    Trata-se de uma reflexão teórica que tem por objetivo estimular os leitores a repensar o papel da educação permanente dos sujeitos-trabalhadores da saúde e de enfermagem na perspectiva do desenvolvimento individual e coletivo, por meio da práxis transformadora. Procurou-se fazer uma articulação reflexiva dos princípios da práxis transformadora apresentada pelo filósofo Adolfo Sánchez Vázquez com os preceitos de educação permanente em saúde e no trabalho de enfermagem. Tal articulação apresent...

  6. A proposta da educação permanente em saúde na atualização da equipe de saúde em diabetes mellitus

    OpenAIRE

    Rodrigues,Andreia Cristinha Seabra; Vieira,Gisele de Lacerda Chaves; Torres,Heloisa de Carvalho

    2010-01-01

    O objetivo do estudo foi relatar a experiência da Educação Permanente em Saúde na atualização da equipe de saúde de uma Unidade Básica de Saúde para a atenção integral e humanizada às pessoas com diabetes tipo 2. A metodologia de escolha para a capacitação das equipes de saúde foi a Educação em Permanente em Saúde, por meio de oficinas educativas em diabetes com enfoque na problematização do processo educativo e profissional. Buscou-se, assim, construir um programa de educação em diabetes vis...

  7. La aspiración de Brasil al asiento permanente en el Consejo de Seguridad de la Organización de las Naciones Unidas: un breve panorama

    Directory of Open Access Journals (Sweden)

    Renata de Melo Rosa

    2009-12-01

    Full Text Available Este artículo analiza la posición de Brasil frente a la aspiración de un asiento permanente al Consejo de Seguridad de las Naciones Unidas. Los esfuerzos entabulados por Brasil en el escenario internacional, los discursos del primer rango del gobierno, así como un protagonismo más acelerado frente a los vecinos latino-americanos confirman esta aspiración. Pero, Brasil aún enfrenta serios problemas internos de seguridad nacional y tendrá que enfrentar otros compañeros regionales también, aspirantes a un assiento de miembro permanente en el Consejo de Seguridad de la ONU, como Canadá, por ejemplo. La ocupación del assiento temporario en el bienio de 2010-2011 también es uno de los factores analizados en este trabajo.

  8. Educação Permanente no cotidiano da Atenção Básica no Mato Grosso do Sul

    Directory of Open Access Journals (Sweden)

    Jacinta de Fátima Franco Pereira Machado

    Full Text Available O artigo analisou as ações de Educação Permanente em Saúde na Atenção Básica em Mato Grosso do Sul, Brasil, na perspectiva de 184 equipes participantes da primeira fase do Programa de Melhoria do Acesso e da Qualidade (PMAQ, de junho de 2012 a fevereiro de 2013. Entre as ações de Educação Permanente, os cursos presenciais foram mais prevalentes, seguidos por troca de experiência, teleducação, ensino à distância e tutoria/preceptoria, tanto na capital quanto no interior. As ações de planejamento e apoio à gestão foram mais prevalentes na capital. As ações de apoio da gestão estavam diretamente relacionadas com o planejamento e a organização do processo de trabalho.

  9. EL DESARROLLO PROFESIONAL MEDIANTE LA FORMACION PERMANENTE DE LOS PROFESORES CUBANOS DE MATEMÁTICA Y CIENCIAS PARA TRABAJAR EN PAISES DE HABLA INGLESA

    Directory of Open Access Journals (Sweden)

    Noelio Vázquez Vargas

    2014-12-01

    Full Text Available Este artículo trata sobre el desarrollo profesional. Se presenta un estudio histórico sobre la enseñanza del inglés con fines específicos (IFE durante la formación permanente de los profesores cubanos de Matemática y Ciencias, además, se presentan las competencias básicas de los profesores de estas asignaturas, teniendo en cuenta el criterio de diferentes autores.

  10. Nitric Oxide Synthase Enzymes in the Airways of Mice Exposed to Ovalbumin: NOS2 Expression Is NOS3 Dependent

    Directory of Open Access Journals (Sweden)

    Jennifer M. Bratt

    2010-01-01

    Full Text Available Objectives and Design. The function of the airway nitric oxide synthase (NOS isoforms and the lung cell types responsible for its production are not fully understood. We hypothesized that NO homeostasis in the airway is important to control inflammation, which requires upregulation, of NOS2 protein expression by an NOS3-dependent mechanism. Materials or Subjects. Mice from a C57BL/6 wild-type, NOS1−/−, NOS2−/−, and NOS3−/− genotypes were used. All mice strains were systemically sensitized and exposed to filtered air or ovalbumin (OVA aerosol for two weeks to create a subchronic model of allergen-induced airway inflammation. Methods. We measured lung function, lung lavage inflammatory and airway epithelial goblet cell count, exhaled NO, nitrate and nitrite concentration, and airway NOS1, NOS2, and NOS3 protein content. Results. Deletion of NOS1 or NOS3 increases NOS2 protein present in the airway epithelium and smooth muscle of air-exposed animals. Exposure to allergen significantly reduced the expression of NOS2 protein in the airway epithelium and smooth muscle of the NOS3−/− strain only. This reduction in NOS2 expression was not due to the replacement of epithelial cells with goblet cells as remaining epithelial cells did not express NOS2. NOS1−/− animals had significantly reduced goblet cell metaplasia compared to C57Bl/6 wt, NOS2−/−, and NOS3−/− allergen-exposed mice. Conclusion. The airway epithelial and smooth muscle cells maintain a stable airway NO concentration under noninflammatory conditions. This “homeostatic” mechanism is unable to distinguish between NOS derived from the different constitutive NOS isoforms. NOS3 is essential for the expression of NOS2 under inflammatory conditions, while NOS1 expression contributes to allergen-induced goblet cell metaplasia.

  11. Nitric Oxide Synthase Enzymes in the Airways of Mice Exposed to Ovalbumin: NOS2 Expression Is NOS3 Dependent

    Science.gov (United States)

    Bratt, Jennifer M.; Williams, Keisha; Rabowsky, Michelle F.; Last, Michael S.; Franzi, Lisa M.; Last, Jerold A.; Kenyon, Nicholas J.

    2010-01-01

    Objectives and Design. The function of the airway nitric oxide synthase (NOS) isoforms and the lung cell types responsible for its production are not fully understood. We hypothesized that NO homeostasis in the airway is important to control inflammation, which requires upregulation, of NOS2 protein expression by an NOS3-dependent mechanism. Materials or Subjects. Mice from a C57BL/6 wild-type, NOS1−/−, NOS2−/−, and NOS3−/− genotypes were used. All mice strains were systemically sensitized and exposed to filtered air or ovalbumin (OVA) aerosol for two weeks to create a subchronic model of allergen-induced airway inflammation. Methods. We measured lung function, lung lavage inflammatory and airway epithelial goblet cell count, exhaled NO, nitrate and nitrite concentration, and airway NOS1, NOS2, and NOS3 protein content. Results. Deletion of NOS1 or NOS3 increases NOS2 protein present in the airway epithelium and smooth muscle of air-exposed animals. Exposure to allergen significantly reduced the expression of NOS2 protein in the airway epithelium and smooth muscle of the NOS3−/− strain only. This reduction in NOS2 expression was not due to the replacement of epithelial cells with goblet cells as remaining epithelial cells did not express NOS2. NOS1−/− animals had significantly reduced goblet cell metaplasia compared to C57Bl/6 wt, NOS2−/−, and NOS3−/− allergen-exposed mice. Conclusion. The airway epithelial and smooth muscle cells maintain a stable airway NO concentration under noninflammatory conditions. This “homeostatic” mechanism is unable to distinguish between NOS derived from the different constitutive NOS isoforms. NOS3 is essential for the expression of NOS2 under inflammatory conditions, while NOS1 expression contributes to allergen-induced goblet cell metaplasia. PMID:20953358

  12. Necesidades y motivaciones de los estudiantes de educación permanente en España. El caso del Centro de Educación Permanente Valle del Guadiato en Córdoba

    Directory of Open Access Journals (Sweden)

    Beatriz del V. Medina F

    2013-05-01

    Full Text Available El objetivo de la investigación en la que está basado el artículo fue identificar las necesidades y las motivaciones de los estudiantes del Centro de Educación Permanente (CEPER Valle del Guadiato de Córdoba, España. Se parte de diferentes teorías para su fundamentación, como las aportadas por Maslow (2005, McClelland (1989, García Aretio (1988, Paz (1984, Palladino (1981, entre otros. Se utilizó la metodología comparada cuyas unidades de comparación se corresponden con las unidades espaciales, que en este estudio son los municipios: Belmez, Espiel, Fuente Obejuna, Peñarroya-Pueblonuevo, Villanueva del Rey y Villaviciosa de Córdoba. Para la recogida de datos se utiliza el estudio documental, el cuestionario escrito y la observación cualitativa. El universo poblacional del CEPER Valle del Guadiato lo conformaron 606 personas adultas del período escolar 2011-2012 (592 estudiantes, 14 maestros, siendo la muestra de 265 personas (251 estudiantes, 14 maestros. Entre las principales conclusiones destacan que las necesidades sociales, laborales y personales de los estudiantes del Centro objeto de estudio se derivan básicamente del deseo de aprender, del deseo de superación personal, y del interés por el tema. Las motivaciones giran en torno a la oportunidad de ocupar sus tiempos libres, a la posibilidad de tener mejores oportunidades de encontrar trabajo, y al apoyo de la familia.

  13. Necesidades y motivaciones de los estudiantes de educación permanente en España. El caso del Centro de Educación Permanente Valle del Guadiato en Córdoba

    Directory of Open Access Journals (Sweden)

    Beatriz del V. Medina F

    2013-01-01

    Full Text Available El objetivo de la investigación en la que está basado el artículo fue identifi-car las necesidades y las motivaciones de los estudiantes del Centro de Educación Permanente (CEPER Valle del Guadiato de Córdoba, España. Se parte de dife-rentes teorías para su fundamentación, como las aportadas por Maslow (2005,McClelland (1989, García Aretio (1988, Paz (1984, Palladino (1981, entre otros. Se utilizó la metodología comparada cuyas unidades de comparación se co-rresponden con las unidades espaciales, que en este estudio son los municipios: Belmez, Espiel, Fuente Obejuna, Peñarroya-Pueblo nuevo, Villanueva del Rey y Villaviciosa de Córdoba. Para la recogida de datos se utiliza el estudio documental, el cuestionario escrito y la observación cualitativa. El universo poblacional del “CEPER Valle del Guadiato” lo conformaron 606 personas adultas del período escolar 2011-2012 (592 estudiantes, 14 maestros, siendo la muestra de 265 personas (251 estudiantes, 14 maestros. Entre las principales conclusiones destacan que las necesidades sociales, laborales y personales de los estudiantes del Centro objeto de estudio se derivan básicamente del deseo de aprender, del deseo de superación personal, y del interés por el tema. Las motivaciones giran en torno a la oportunidad de ocupar sus tiempos libres, a la posibilidad de tener mejores oportunidades de encontrar trabajo, y al apoyo de la familia.

  14. IMAS-Fish: Integrated MAnagement System to support the sustainability of Greek Fisheries resources. A multidisciplinary web-based database management system: implementation, capabilities, utilization and future prospects for fisheries stakeholde

    Directory of Open Access Journals (Sweden)

    S. KAVADAS

    2013-03-01

    Full Text Available This article describes in detail the “IMAS-Fish” web-based tool implementation technicalities and provides examples on how can it be used for scientific and management purposes setting new standards in fishery science. “IMAS-Fish” was developed to support the assessment of marine biological resources by: (i homogenizing all the available datasets under a relational database, (ii facilitating quality control and data entry, (iii offering easy access to raw data, (iv providing processed results through a series of classical and advanced fishery statistics algorithms, and (v visualizing the results on maps using GIS  technology. Available datasets cover among others: Fishery independent experimental surveys data (locations, species, catch compositions, biological data; Commercial fishing activities (fishing gear, locations, catch compositions, discards; Market sampling data (species, biometry, maturity, ageing; Satellite derived ocean data (Sea surface temperature, Salinity, Wind speed, Chlorophyll-a concentrations, Photosynthetically active radiation; Oceanographic parameters (CTD measurements; Official national fishery statistics; Fishing fleet registry and VMS  data; Fishing ports inventory; Fishing legislation archive (national and EU; Bathymetry grids. Currently, the homogenized database holds a total of more than 100,000,000 records. The web-based application is accessible through an internet browser and can serve as a valuable tool for all involved stakeholders: fisheries scientists, state officials responsible for management, fishermen cooperatives, academics, students and NGOs.

  15. Multifaceted NOS Instruction: Contextualizing Nature of Science with Documentary Films

    Science.gov (United States)

    Bloom, Mark; Binns, Ian C.; Koehler, Catherine

    2015-01-01

    This research focuses on inservice science teachers' conceptions of nature of science (NOS) before and after a two-week intensive summer professional development (PD). The PD combined traditional explicit NOS instruction, numerous interactive interventions that highlighted NOS aspects, along with documentary films that portrayed NOS in context of…

  16. Orthodontic force stimulates eNOS and iNOS in rat osteocytes

    NARCIS (Netherlands)

    Tan, S.D.; Xie, R.; Klein Nulend, J.; van Rheden, R.E.; Bronckers, A.L.J.J.; Kuijpers-Jagtman, A.M.; Von den Hoff, J.W.; Maltha, J.C.

    2009-01-01

    Mechanosensitive osteocytes are essential for bone remodeling. Nitric oxide, an important regulator of bone remodeling, is produced by osteocytes through the activity of constitutive endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). We hypothesized that these

  17. Orthodontic force stimulates eNOS and iNOS in rat osteocytes.

    NARCIS (Netherlands)

    Tan, S.D.; Xie, R.; Klein-Nulend, J.; Rheden, R.E.M. van; Bronckers, A.L.; Kuijpers-Jagtman, A.M.; Hoff, J.W. Von den; Maltha, J.C.

    2009-01-01

    Mechanosensitive osteocytes are essential for bone remodeling. Nitric oxide, an important regulator of bone remodeling, is produced by osteocytes through the activity of constitutive endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). We hypothesized that these

  18. Integrated modeling of agricultural scenarios (IMAS) to support pesticide action plans: the case of the Coulonge drinking water catchment area (SW France).

    Science.gov (United States)

    Vernier, Françoise; Leccia-Phelpin, Odile; Lescot, Jean-Marie; Minette, Sébastien; Miralles, André; Barberis, Delphine; Scordia, Charlotte; Kuentz-Simonet, Vanessa; Tonneau, Jean-Philippe

    2017-03-01

    Non-point source pollution is a cause of major concern within the European Union. This is reflected in increasing public and political focus on a more sustainable use of pesticides, as well as a reduction in diffuse pollution. Climate change will likely to lead to an even more intensive use of pesticides in the future, affecting agriculture in many ways. At the same time, the Water Framework Directive (WFD) and associated EU policies called for a "good" ecological and chemical status to be achieved for water bodies by the end of 2015, currently delayed to 2021-2027 due to a lack of efficiency in policies and timescale of resilience for hydrosystems, especially groundwater systems. Water managers need appropriate and user-friendly tools to design agro-environmental policies. These tools should help them to evaluate the potential impacts of mitigation measures on water resources, more clearly define protected areas, and more efficiently distribute financial incentives to farmers who agree to implement alternative practices. At present, a number of reports point out that water managers do not use appropriate information from monitoring or models to make decisions and set environmental action plans. In this paper, we propose an integrated and collaborative approach to analyzing changes in land use, farming systems, and practices and to assess their effects on agricultural pressure and pesticide transfers to waters. The integrated modeling of agricultural scenario (IMAS) framework draws on a range of data and expert knowledge available within areas where a pesticide action plan can be defined to restore the water quality, French "Grenelle law" catchment areas, French Water Development and Management Plan areas, etc. A so-called "reference scenario" represents the actual soil occupation and pesticide-spraying practices used in both conventional and organic farming. A number of alternative scenarios are then defined in cooperation with stakeholders, including socio

  19. Educação permanente em saúde e as Diretrizes Curriculares Nacionais para Educação das relações étnico-raciais e para ensino de História e Cultura Afro-Brasileira e Africana

    Directory of Open Access Journals (Sweden)

    Rosana Batista Monteiro

    Full Text Available Resumo Este texto é um ensaio sobre algumas contribuições que o curso de especialização em Saúde da Mulher Negra pode ter produzido para a abordagem dos conteúdos relacionados nas Diretrizes Curriculares Nacionais para a Educação das Relações Étnico-raciais e para o Ensino de História e Cultura Afro-brasileira e Africana, bem como em atenção à Política Nacional de Saúde Integral da População Negra, com destaque para a educação permanente. A partir de breve contextualização sobre o debate no campo das relações raciais e ações afirmativas no Brasil passamos a apresentar a organização e funcionamento do curso, destacando seus objetivos, conteúdos, estratégias. Com foco nos profissionais da saúde, o curso contou com significativa presença de profissionais da educação básica pública, municipal e estadual, das cidades de São Luís e Pinheiro, no Maranhão, implicando a discussão do tema saúde da população negra (especialmente da mulher negra no âmbito da escola. O curso propiciou a elaboração de projetos de pesquisa relacionados diretamente com o atendimento à saúde de mulheres negras e sua relação com processos formativos de profissionais da área da saúde, bem como educação escolar e saúde de mulheres negras. Pode-se concluir, ainda que provisoriamente, que o curso, na perspectiva da educação permanente, resultou em estratégia eficaz para o desenvolvimento de conteúdos relacionados às DCNERER e, especialmente, de viabilização de implementação da Política Nacional de Saúde Integral da População Negra, realizadas ou desencadeadas nos serviços de saúde pelos cursistas.

  20. Expansão rápida da maxila ancorada em implantes: uma nova proposta para expansão ortopédica na dentadura permanente Rapid maxillary expansion anchored by implants: a new proposal to orthopedic expansion in the permanent dentition

    Directory of Open Access Journals (Sweden)

    Daniela Gamba Garib

    2007-06-01

    Full Text Available OBJETIVO: este trabalho apresenta um método para expansão ortopédica da maxila, na dentadura permanente, utilizando implantes como ancoragem. METODOLOGIA: detalharam-se os procedimentos cirúrgicos e laboratoriais da confecção de um expansor com ancoragem dento-óssea em crânio seco humano. Dois implantes de titânio foram colocados na região anterior do palato, e o parafuso Hyrax adaptado de modo que a expansão ancorou-se nos implantes e nos primeiros molares permanentes. RESULTADOS: o experimento laboratorial em crânio seco mostrou que o procedimento apresenta-se anatômica e operacionalmente viável. Os implantes suportaram a força gerada pela ativação do parafuso expansor, redundando na separação transversal das hemimaxilas. CONCLUSÕES: vislumbra-se que a expansão rápida da maxila ancorada em implantes (ERMAI poderá potencializar a eficiência da expansão ortopédica, assim como reduzir o custo periodontal dos procedimentos convencionais de expansão. Futuros estudos clínicos são necessários para testar essas hipóteses.AIM: This study presents a method for maxillary orthopedic expansion, in the permanent dentition, using implants as anchorage. METHODS: Surgical and laboratorial procedures for the construction of a tooth-bone-borne expansor was detailed in a human dry skull. Two titanium implants were placed in the anterior region of the palate and a Hyrax screw was adapted in a way that the expansion was anchored both on the palatal implants and on permanent first molars. RESULTS: The laboratorial experiment in dry skull showed that the procedure is operationally and anatomically possible. The implants supported the force generated by the expansion screw activation and the maxilla halves were transversally split. CONCLUSIONS: Rapid maxillary expansion anchored on implants can increase the efficiency of orthopedic expansion and decrease the periodontal sequela caused by conventional RME. Further clinical studies are

  1. Programa de Capacitação Permanente de Conselheiros Populares de Saúde na cidade de São Paulo São Paulo city: Permanent Skills Improvement Course for elected representatives to the Municipal Health Councils

    Directory of Open Access Journals (Sweden)

    Cláudia Maria Bógus

    2003-12-01

    Full Text Available O Movimento Popular de Saúde do Município de São Paulo vem elegendo Conselhos Populares de Saúde desde 1979. A questão da formação política e capacitação técnica de lideranças sempre foi uma preocupação do movimento de saúde. Durante a gestão municipal de 1993 a 2000 a interlocução entre o governo local e a representação popular foi rompida e disto decorreu um período de refluxo dos movimentos sociais. Porém, no início de 1998, os movimentos organizados de saúde das regiões leste e sudeste conseguiram se articular para eleger conselheiros para os Conselhos Populares de Saúde. Foram eleitos 1.039 conselheiros. Após vários esforços isolados de capacitação de conselheiros optou-se por realizar um Programa de Capacitação Permanente de Conselheiros de Saúde como forma de envolver o conjunto de bairros e regiões. Por meio de um convênio entre o Ministério da Saúde e o Centro de Educação Permanente da Faculdade de Saúde Pública da Universidade de São Paulo foram realizados 52 cursos para 1.011 desses conselheiros eleitos. Neste trabalho, a partir de análise documental, os autores descrevem esse processo de capacitação, caracterizam o perfil sócio econômico dos conselheiros e analisam a avaliação dos participantes nos cursos de capacitação.The popular health movement from São Paulo City has been electing Popular Health Councils since 1979. The issue of political and technical capabilities of its leaders has been an important point for the movement. During the years 1993 to 2000, the communication channels between the municipal government and popular leadership have been broken, leading back the social movement related to public health. However, in the beginningof 1988, the organized health movements located both at the east and southeast parts of São Paulo City, were succeeded in electing 1.039 members for those popular councils. After several scattered efforts to provide capability and skills to the

  2. Obtención del Valor Genético Predicho en Animales Incluyendo el Efecto del Medio Ambiente Permanente Obtención del Valor Genético Predicho en Animales Incluyendo el Efecto del Medio Ambiente Permanente

    Directory of Open Access Journals (Sweden)

    Mauricio Valencia Posadas

    2012-02-01

    Full Text Available The genetic improvement of the animals based in productive records and genealogical information, is a fundamental mechanism to increase the economic income of the commercial farms, through the estimation of the predicted breeding values (VGP’s. The VGP’s allows the identification of animals genetically superior to be used as parents of the next generation. In many parts of the world the best linear unbiased predictor procedure (MPLI is used as an animal model, for its appropriate properties, to obtain the VGP’s. In these models the permanent environment effect is usually included in order to increase the accuracy of the VGP’s. In this work a developed example is presented using supposed data to obtain VGP’s with the MPLI procedure and an animal model where the methodology, interpretation and use of the VGP’s are shown.El mejoramiento genético de los animales, con base en los registros de rendimiento e información genealógica, es un mecanismo fundamental para incrementar los rendimientos económicos de las explotaciones comerciales, a partir de la estimación de valores genéticos predichos (VGP’s. Los VGP permiten identificar a los animales genéticamente superiores de una forma objetiva, para que sean utilizados como padres de la siguiente generación. En muchas partes del mundo se utiliza el procedimiento del mejor predictor lineal insesgado (MPLI con un modelo animal por sus adecuadas propiedades para obtenerlos VGP’s. En dichos modelos se suele incluir el efecto del medio ambiente permanente con el objeto de incrementar la precisión de los VGP’s. En este trabajos e presenta un ejemplo desarrollado utilizando datos supuestos para obtener VGP’s con el procedimiento MPLI y un modelo animal, donde se muestra la metodología, interpretación y uso que tienen los VGP’s.

  3. Marketing plan NOS: introducing pay per view

    OpenAIRE

    Pereira, Pedro Azeredo

    2016-01-01

    NOS, NOS Comunicações S.A., is a private telecommunications company of the portuguese market which is proud of being the “best communications and entertainment company in the market”. The company was born from a fusion between two of the biggest communications corporations in the country: on the fixed service (TV, fixed phone, fixed internet, etc.) from ZON; and on the mobile service (mobile phone, internet, etc.) from Optimus. It is a leader in all the sectors it operates. Bes...

  4. Association between clinical parameters and the presence of active caries lesions in first permanent molars Associação entre parâmetros clínicos e a presença de lesões ativas de cárie em primeiros molares permanentes

    Directory of Open Access Journals (Sweden)

    Juliana Maria Quaglio

    2006-12-01

    ativas em outros dentes, índice de placa, arco dentário do dente (superior ou inferior, lado do dente (direito ou esquerdo, presença de placa visível e grau de erupção dos primeiros molares permanentes. Os primeiros molares permanentes foram avaliados usando inspeção visual por dois examinadores para avaliar a presença de lesões de cárie ativas ou inativas sobre a superfície oclusal. Análises univariada e multivariada para avaliação da associação dos parâmetros clínicos e presença de lesões ativas nesses dentes foram realizadas. A presença de manchas brancas ativas em outros dentes apresentou associação significante com a presença de lesões ativas de cárie nos primeiros molares permanentes, em ambas as análises univariada e multivariada ("Odds ratio" = 8,8 e 1,9, respectivamente. A presença de placa visível abundante sobre a superfície oclusal dos primeiros molares permanentes ("Odds ratio" = 3,5 na análise univariada, e 3,9 na análise multivariada também apresentou associação significante. Em conclusão, a presença de manchas brancas ativas em outros dentes e a presença de placa visível abundante apresentaram associação com a presença de lesões ativas de cárie sobre a superfície oclusal dos primeiros molares permanentes.

  5. Educação à Distância como estratégia para a educação permanente em saúde: possibilidades e desafios Educación a la Distancia como estratégia para la educación permanente en salud: posibilidades y desafíos Distance Education as strategy for permanent education in health: possibilities and challenges

    Directory of Open Access Journals (Sweden)

    Marluce Alves Nunes Oliveira

    2007-10-01

    Full Text Available Este estudo objetivou refletir sobre a importância da Educação Permanente em Saúde (EPS na promoção do processo de mudança nos docentes da UEFS; estabelecer estratégias para a promoção da EPS e apontar as possibilidades e os desafios para a operacionalização da EAD como estratégia para a EPS. Estudo de revisão bibliográfica. O resultado aponta que a EPS é uma das estratégias para a formação do profissional através de trabalhos coletivos entre os docentes. Como possibilidade: EAD possibilita construir um novo estilo na formação. Desafios: necessidade de conhecimento para utilizar as novas tecnologias da informação e comunicação; dificuldade de acesso a estas tecnologias; escassez de tempo para desenvolver as atividades do curso. Apreendemos que a EAD apresenta nova perspectiva para EPS.Este estudio buscó reflexionar al respecto de la importancia de la Educación Permanente em Salud (EPS em la promoción del proceso de cambios em los docentes de la Universidad Estatal de Feira de Santana (UEFS; establecer estratégias para la promoción de la EPS y apuntar las posibilidades y los desafíos para la operacionalización de la Educación a la Distancia (EAD como estratégia para la EPS. Estudio de una revización bibliográfica. El resultado apunta a que la EPS és una de las estratégias para la formación del profesional por médio de trabajos colectivos entre los docentes. Como posibilidad: EAD posibilita construir um nuevo estilo em lá formación. Desafíos: necesidad de conocimiento para utilizar las nuevas tecnologíes de la información y comunicación; dificultad de acceso a estas tecnologias; poco tiempo para desarrollar las actividades del curso. Aprendimos que la EAD presenta nueva perspectiva para la EPS.The point of this study is to reflect about how important Permanent Education in Health (PEH is in the promotion of the changes process of professors of UEFS; to establish strategies to promote PEH and show the

  6. A nova gestão pública na Inglaterra: a permanente instabilidade da reforma neoliberal

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    David Hall

    2015-09-01

    Full Text Available RESUMO: A reforma da educação na Inglaterra tem sido intimamente associada a um programa mais amplo da nova gestão pública, centrado na reforma dos serviços públicos. Este artigo analisa as características deste programa de reformas inspirado na NGP, tendo em vista que o sistema educacional inglês se deslocou de uma forma cívica e de proteção social ("cívico-welfarista" para um modo em que o neoliberalismo despontou em ascendência. Atenção particular é dada tanto aos aspectos centralizadores da reforma, em que tem havido um acentuado aumento na intervenção do governo central na educação, quanto aos aspectos descentralizadores da reforma, incluindo a criação de escolas como unidades de negócios e a mercantilização da educação em termos mais gerais. As origens das reformas estão situadas em uma construção discursiva de uma crise educacional, inspirada na Nova Direita, que encontrou posterior expressão em uma série de alterações na legislação que emergiram de e cimentaram um consenso educacional trans-político-partidário que já perdura por mais de trinta anos neste contexto. Este artigo examina os efeitos dessas reformas da NGP na educação na Inglaterra, e as continuidades e descontinuidades entre as diferentes administrações políticas, considerando que a Inglaterra passou por sucessivas ondas de reformas até chegarmos a um período pós-NGP. Concluímos que a permanente instabilidade do sistema educacional inglês pode ser identificado nas tensões que atingem o próprio âmago do processo da NGP, de formas que, antecipamos, continuarão a perturbar um setor rapidamente privatizador.

  7. Evaluación de la formación permanente del profesorado en la República Dominicana : el caso del Infocam

    OpenAIRE

    Ayala de la Cruz, María Esperanza

    2016-01-01

    El presente estudio estuvo orientado a describir y valorar la calidad del sistema de formación, relacionándolo con la aplicación de las políticas educativas y de formación permanente o continua del profesorado en la República Dominicana. Su conexión con las necesidades e intereses de los docentes, su incidencia en el desarrollo personal, profesional, y de desempeño. Teniendo como intención estratégica generar y aportar líneas para avanzar hacia un sistema de evaluación de la formación...

  8. Ações de educação permanente dos enfermeiros facilitadores de um núcleo de educação em enfermagem

    OpenAIRE

    Lavich, Claudia Rosane Perico; Gomes Terra, Marlene; Lemos Mello, Amanda; Raddatz, Michele; Arnemann, Cristiane Trivisiol

    2017-01-01

    Objetivo: Identificar ações desenvolvidas por enfermeiros facilitadores de um Núcleo de Educação Permanente de um Hospital de Ensino.Método: Estudo de caso único com abordagem qualitativa, realizado com oito enfermeiros de um hospital no Estado do Rio Grande do Sul. A produção dos dados foi por meio de análise documental, observação sistemática e grupo focal, realizada de abril a setembro de 2013.Resultados: O estudo aponta para as seguintes categorias: estratégias potentes para promover açõe...

  9. La aspiración de Brasil al asiento permanente en el Consejo de Seguridad de la Organización de las Naciones Unidas: un breve panorama

    OpenAIRE

    Renata de Melo Rosa; Ana Carolina Gomes Lira Linhares

    2009-01-01

    Este artículo analiza la posición de Brasil frente a la aspiración de un asiento permanente al Consejo de Seguridad de las Naciones Unidas. Los esfuerzos entabulados por Brasil en el escenario internacional, los discursos del primer rango del gobierno, así como un protagonismo más acelerado frente a los vecinos latino-americanos confirman esta aspiración. Pero, Brasil aún enfrenta serios problemas internos de seguridad nacional y tendrá que enfrentar otros compañeros regionales también, aspir...

  10. Parálisis facial permanente: corrección quirúrgica con la técnica de Labbé

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    Rubén Yangali

    2008-12-01

    Full Text Available La parálisis facial genera un gran déficit estético y funcional. Las diversas técnicas quirúrgicas han ido evolucionando, a fin de corregir este defecto de la forma más estructural y fisiológica posible. Consideramos que la mioplastia de alargamiento del temporal constituye actualmente la técnica de elección para corregir los casos de parálisis facial permanente.

  11. Extração de eletrodo de marcapasso endocárdico permanente pela aplicação de radiofreqüência

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    Roberto COSTA

    1998-04-01

    Full Text Available Introdução: Uma nova opção terapêutica para a remoção de cabos-eletrodo endocárdicos permanentes desativados é apresentada, utilizando a radiofreqüência para facilitar a liberação do eletrodo a partir do endocárdio, permitindo a extração transvenosa do sistema. Os resultados obtidos nos 4 primeiros pacientes tratados são apresentados. Casuística: Quatro pacientes portadores de processos infecciosos em eletrodos transvenosos abandonados foram submetidos a procedimento para remoção do cateter. Todos os pacientes eram portadores de eletrodos de fixação passiva por aletas implantados no ventrículo direito de 8,5 a 18,8 anos (M = 12,9 ± 5,6 antes. Em todos os casos a técnica da tração contínua havia sido utilizada exaustivamente, não se conseguindo a remoção. Métodos: Utilizou-se gerador de radiofreqüência Radionics RFG3D com anodo de 85 cm2 justaposto ao dorso do paciente e usou-se como catodo o próprio eletrodo a ser removido. Concomitante à tração contínua do cabo-eletrodo a aplicação de radiofreqüência era iniciada. Para cada paciente foram realizadas até três aplicações de 50 W com um tempo máximo de aplicação de 60 segundos em cada aplicação. O tempo e a potência foram determinados empiricamente pela equipe médica, considerando-se insucesso a não liberação do eletrodo a partir do miocárdio após a aplicação do montante de energia acima descrito. Resultados: O cabo-eletrodo foi removido completamente em 2 pacientes. Em 1, a radiofreqüência dissolveu a solda do condutor à ponta do eletrodo, que ficou presa ao miocárdio e no último paciente não houve liberação do cabo após o uso da máxima energia preestabelecida. Não houve complicações ou óbitos. Conclusões: A radiofreqüência pode ser usada como opção terapêutica para a liberação transvenosa de eletrodos abandonados. Maior experiência deve ser obtida para determinar a energia que deve ser utilizada para maximizar os

  12. El conocimiento de los records como motivación en la preparación del equipo permanente de atletismo de la ESBU Antero Fernández Vargas del municipio San Juan y Martínez

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    José Manuel Vives Morejón

    2009-09-01

    Full Text Available Ha sido en los últimos años la introducción del deporte participativo, una de las vías que facilite a la gran masa estudiantil la práctica del deporte de forma masiva y organizada. Los profesores preparan a sus alumnos en los deportes según el nivel de enseñanza, lo que representa un gran estimulo para el profesor de Educación Física y sus alumnos, los cuales transitan desde la base hasta el nivel nacional, de ahí que se necesite conocer el estado en que se encuentran sus alumnos desde el punto de vista físico, deportivo y motivacional. El atletismo es uno de los deportes que está presente en todos los niveles de participación, pero en nuestra escuela ocupa el último lugar dentro de la preferencia de los estudiantes, lo que nos incitó investigar al respecto con vistas a lograr niveles óptimos de motivación para la práctica sistemática de este deporte, de ahí que durante la realización de las pruebas de eficiencia física, competencias mensuales de atletismo, deporte participativo, hemos recopilado cada uno de los eventos y diseñado en el centro un sistema de estimulación desde la clase, el mural de educación física y los actos centrales de la escuela para dar a cono cer los mejores resultados, quedando establecidos como records dentro de la escuela de forma permanente, esto ha motivado a los estudiantes a querer conocer sus potencialidades en cada uno de los eventos y si han superado los resultados alcanzados por los estudiantes en cursos anteriores, lo que se ha convertido en un recurso importante para estimular la preparación de los integrantes del equipo de atletismo de nuestra escuela, donde todos quieren estar en el equipo y entre los recordistas del centro.

  13. Prevalência de cárie em dentes permanentes de escolares do Município de São Paulo, SP, 1970-1996 Dental caries prevalence in permanent teeth of schoolchildren in Brazil, 1970-1996

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    Paulo C Narvai

    2000-04-01

    Full Text Available OBJETIVO: Estudar a evolução da prevalência de cárie em dentes permanentes da população infantil do Município de São Paulo, SP, no período 1970-1996, com base em levantamento epidemiológico em escolares das redes pública e privada de ensino. MÉTODOS: Utilizando metodologia recomendada pela Organização Mundial da Saúde, foram examinados 2.491 escolares de 103 unidades das redes de ensino público e privado. Foi obtida amostra probabilística, com base no cadastro das escolas do município. Os elementos amostrais foram identificados ao acaso. RESULTADOS: Observou-se que de uma situação de prevalência "muito alta" de cárie dentária nos anos 60 e 70, a população de referência evoluiu positivamente, na idade-índice de 12 anos, para um quadro de "baixa" prevalência. CONCLUSÃO: Entre 1986 e 1996 o declínio na cárie dentária, aos 12 anos de idade, foi da ordem de 68,2% entre escolares do Município de São Paulo.OBJECTIVE: To assess the evolution of dental caries in permanent teeth of schoolchildren in S. Paulo City, Brazil, during the period of 1970-1996. METHODS: The World Health Organization methodology for oral health surveys was applied in 2,491 shoolchildren, both male and female from 103 public and private schools. A probabilistic sample stratified by age, school category, and city zones was obtained by the Education State Service data system. Computational resources were used. RESULTS: Data from the 1996 S.Paulo survey were compared with others data provided by studies such as the one conducted in the same city and the reference-population in the second half of the 20th century. In the 60s and 70s the DMF-T Index among 12-year-old schoolchildren was around 7.0. In 1986 it was 6.5 and in 1996 it was registered 2.1, a decline of 68%. CONCLUSION: Dental caries in permanent teeth among S. Paulo City 12-year-old schoolchildren changed from a "very high" to "low" prevalence.

  14. Internet infrastructures and health care systems: a qualitative comparative analysis on networks and markets in the British National Health Service and Kaiser Permanente.

    Science.gov (United States)

    Séror, Ann C

    2002-12-01

    The Internet and emergent telecommunications infrastructures are transforming the future of health care management. The costs of health care delivery systems, products, and services continue to rise everywhere, but performance of health care delivery is associated with institutional and ideological considerations as well as availability of financial and technological resources. to identify the effects of ideological differences on health care market infrastructures including the Internet and telecommunications technologies by a comparative case analysis of two large health care organizations: the British National Health Service and the California-based Kaiser Permanente health maintenance organization. A qualitative comparative analysis focusing on the British National Health Service and the Kaiser Permanente health maintenance organization to show how system infrastructures vary according to market dynamics dominated by health care institutions ("push") or by consumer demand ("pull"). System control mechanisms may be technologically embedded, institutional, or behavioral. The analysis suggests that telecommunications technologies and the Internet may contribute significantly to health care system performance in a context of ideological diversity. The study offers evidence to validate alternative models of health care governance: the national constitution model, and the enterprise business contract model. This evidence also suggests important questions for health care policy makers as well as researchers in telecommunications, organizational theory, and health care management.

  15. Antecedentes históricos del proceso de formación permanente del maestro tutor y su sistematización

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    MSc. Nirma Pérez-Pelipiche

    2016-02-01

    Full Text Available El estudio histórico realizado permitió evidenciar que la formación permanente de los maestros tutores de los estudiantes de Licenciatura en Educación Primaria ha transitado desde de una concepción espontánea, ocasional y a veces improvisada, hacia una más organizada en la que se han asumido posiciones de constantes cambios a favor del proceso formativo universitario pedagógico. Sin embargo, aún persisten restricciones epistemológicas y praxiológicas que limitan su efectividad, siendo notorio en el contexto de la microuniversidad durante la práctica laboral de los estudiantes en formación. Los estudios revelan que si bien el maestro tutor se erige en una figura esencial del proceso formativo pedagógico, no siempre su preparación ha sido efectiva, por lo que se requiere de una dinámica contextualizada de formación permanente que propicie nuevos sistemas de relaciones, vías y actitudes que actualicen y renueven las formas de ejercer sus funciones formativas en correspondencia con la realidad educativa contemporánea.

  16. A Linguagem Motion Graphics nos Videoclipes Brasileiros

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    Herom Vargas

    2013-08-01

    Full Text Available Com o desenvolvimento das tecnologias digitais de edição, animação e pós-produção, a linguagem motion graphics se configurou como ferramenta criativa nas relações entre som e imagem. Este artigo tem como objetivo identificar e analisar aspectos inovadores da utilização da linguagem motion graphics nos videoclipes de artistas brasileiros, no período de 1990 a 2010. Por meio de categorias de avaliação relacionadas 1 aos softwares de composição visual, 2 à evolução da linguagem do clipe no período e 3 às relações entre música, vídeo e gráficos utilizados, quatro estágios de aplicação criativa dos recursos dessa linguagem nos videoclipes brasileiros foram estabelecidos.

  17. ¿Las emociones nos distraen?

    Directory of Open Access Journals (Sweden)

    Antonia Pilar Pacheco-Unguetti

    2014-06-01

    Full Text Available ¿Leerás este artículo hasta el final sin interrupciones? Puede que, mientras lo intentas, recibas algún mensaje de whatsapp, se abra una ventana emergente en tu ordenador con una oferta de viajes al Caribe o el cartero llame dos veces a tu puerta. También puede ser que simplemente no tengas un buen día y te resulte especialmente difícil concentrarte. Vivimos expuestos a multitud de estímulos distractores externos, algunos tan inesperados o extraños que entorpecen irremediablemente nuestra concentración en una tarea (distracción por novedad. Pero la distracción también puede tener una causa interna y cómo nos sentimos puede influir en cuánto nos distraemos.

  18. Educação Médica nos Tempos Modernos

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    Luiz Carlos Lobo

    Full Text Available O artigo enfatiza o aprendizado do aluno e a flexibilização do processo educacional, em regra muito centrado no professor. Propõe o desenvolvimento e a oferta, via internet, de módulos autoinstrucionais sobre a fisiologia e fisiopatologia dos vários sistemas orgânicos, enfatizando sua relação com a clínica, a discussão dos principais agravos à saúde da população e a interação do homem com seu meio físico, biológico e social. Tais módulos poderiam atuar como oportunidades de aprendizagem supletiva e núcleo de discussão dos temas por alunos e professores. Propõe a adoção de uma pedagogia híbrida, em que o aluno teria acesso ao conhecimento via internete a oportunidade de aplicá-lo na solução de problemas de saúde de uma população. Admitindo a limitação da formação profissional desenvolvida apenas no hospital de ensino, o autor propõe a participação ativa e comprometida dos alunos, sob supervisão permanente, nos vários níveis de atenção à saúde, atuando na comunidade, unidades de saúde da família, centros integrados de saúde, hospitais secundários e regionais. Essa proposta é particularmente oportuna no momento em que se cogita a criação de novas escolas de Medicina no País.

  19. Qualidade de Organossolo sob diferentes usos antrópicos em áreas de preservação permanente no Distrito Federal Quality of Histosol under different on anthropic uses in permanent preservation areas in the Distrito Federal

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    Luciano N. de A. e Moura

    2013-01-01

    Full Text Available O uso e a ocupação das terras devem ser planejados de forma racional a fim de evitar impactos ambientais negativos nos recursos naturais, particularmente em áreas ambientalmente protegidas por lei. O objetivo deste trabalho foi avaliar atributos de qualidade dos solos em áreas de preservação permanente da Microbacia do Ribeirão do Gama, Distrito Federal, Brasil, para verificar o efeito do uso antrópico. Foram avaliados atributos físicos, químicos e biológicos de qualidade de organossolos em cinco áreas de uso e ocupação diversificada das terras: três áreas cultivadas (hortaliças, eucalipto e mandioca e duas áreas preservadas (pastagem nativa e mata de galeria. As amostras de solo foram coletadas nas camadas de 0-10 e 10-20 cm. Os dados obtidos pelas análises físicas, químicas e biológicas dos solos foram avaliados estatisticamente por meio do software Sisvar 4.6. Os resultados obtidos mostraram influência dos usos e ocupações diferentes das terras em relação aos atributos de qualidade dos solos. O manejo dos solos adotado nessas áreas foi considerado o principal fator de alteração dos atributos físicos, químicos e biológicos, destacando-se a compactação dos solos sob áreas de vegetação nativa e diminuição da matéria orgânica nos solos em sistemas cultivados.The use and occupation of soil should be planned in a rational way to avoid negative environmental impacts on natural resources, particularly in areas environmentally protected by law. This study aimed to evaluate quality attributes of soil in permanent preservation areas of a Ribeirão do Gama Watershed, Distrito Federal, Brazil, to verify the influence of anthropic use. The physical, chemical and biological attributes of Histosol quality were assessed in five areas of diversified use and soil occupation: three areas under cultivation (vegetables, eucalyptus and cassava and two preserved areas (native pasture and gallery forest. Soil samples were

  20. La formación del profesorado de Historia en Chile. La formación inicial y permanente de los educadores de la V región en el marco de la reforma educacional

    OpenAIRE

    Vásquez Lara, Nelson Lorenzo

    2004-01-01

    [spa] Objetivos Generales:A. Conocer las principales características que ha tenido la formación inicial de los Profesores de Historia, Geografía y Ciencias Sociales chilenos.B. Conocer las principales características que ha tenido la formación permanente de los profesores de Historia, Geografía y Ciencias Sociales chilenos.C. Averiguar la percepción que los profesores de historia chilenos tienen sobre el grado de utilidad de la formación inicial y permanente.D. Averiguar la percepción que lo...

  1. Formación del profesorado de Historia en Chile. La formación inicial y permanente de los educadores de la V región en el marco de la reforma educacional, La

    OpenAIRE

    Vásquez Lara, Nelson Lorenzo

    2004-01-01

    Objetivos Generales:A. Conocer las principales características que ha tenido la formación inicial de los Profesores de Historia, Geografía y Ciencias Sociales chilenos.B. Conocer las principales características que ha tenido la formación permanente de los profesores de Historia, Geografía y Ciencias Sociales chilenos.C. Averiguar la percepción que los profesores de historia chilenos tienen sobre el grado de utilidad de la formación inicial y permanente.D. Averiguar la percepción que los prof...

  2. Aprendizado organizacional nos ciclos de planejamento estratégico de uma instituição financeira pública brasileira

    Directory of Open Access Journals (Sweden)

    Sonia Maria Goulart Gonçalves

    2010-08-01

    Full Text Available As organizações precisam responder, com rapidez, à complexidade dos problemas gerados em ambientes de constantes mudanças, e o planejamento estratégico é a forma encontrada, para combinar conhecimentos e habilidades dos indivíduos e da organização, a fim de criar estratégias que efetivamente gerem resultados sustentáveis e garantam a competitividade da organização. As empresas capazes de se renovarem continuamente por meio da criação de estratégias inovadoras, associadas a um processo constante de aprendizagem organizacional, fundada no questionamento permanente, no diálogo e na interdisciplinaridade, serão as construtoras de amplas vantagens competitivas. Com base nessas premissas, esse artigo visa mostrar a evolução da aprendizagem organizacional nos ciclos de planejamento estratégico de uma instituição fnanceira pública brasileira, de 1992 a 2005, sob a ótica participativa, com base nos conceitos e práticas da interdisciplinaridade.

  3. Educação permanente e qualidade da assistência à saúde: aprendizagem significativa no trabalho da enfermagem

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    Fernanda Maria do Carmo da Silveira Neves de Oliveira

    2011-01-01

    Full Text Available El objetivo de este artículo es analizar la educación permanente en la práctica de la enfermería. En la actualidad, existe preocupación por los cambios introducidos en la estructura de enseñanza y la aplicación de metodologías activas para capacitar profesionales de salud. En el artículo se reflexiona sobre aspectos cotidianos de la enfermería y la manera actual de suministrar o proporcionar información tecnocientífica al enfermero durante la práctica en el hospital, tratando de enriquecer la asistencia de enfermería mediante la educación permanente. Se describen las prácticas trasformadoras aplicadas por el enfermero asistencial como elemento facilitador del proceso enseñanza-aprendizaje. Se lleva a cabo una revisión amplia de las bases de datos informáticas. En consecuencia, la selección de los textos se basa en los criterios de inclusión y exclusión, y dio origen a 50 artículos científicos. En años recientes, la educación permanente se introdujo como un método en el área de la salud, convirtiéndose en un aspecto indispensable en las prácticas de formación, atención, gestión, formulación de políticas públicas y control social. Así se estableció la idea de cuidado total y se trasformaron e integraron los saberes y las prácticas en el ámbito real del público al que va dirigido. Se concluye que la motivación para actualizar permanentemente la práctica profesional del equipo de enfermería prevé la aplicación de un instrumento interdisciplinario de solubilidad que promueva la visibilidad de las acciones por los clientes y sus familias.

  4. La Educación Permanente en Bibliotecología y Archivología: relato de una experiencia universitaria en Uruguay (1994-2001

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    Edelweiss Zahn

    2013-12-01

    Full Text Available Se indica cómo han variado los roles de la información y la situación relativa de las unindades de información, la producción tecnológica de vías alternativas del almacenamiento documental, tales como las bilbiotecas virtuales o digitales, los archivos y museos electrónicos. El avance de la investigación y del conocimiento en cualquier disciplina, el crecimiento de expectativas y necesidades de formación y actualización por parte de los profesionales, nuevos requerimientos y desafíos en el ámbito laboral y social, y la implantación generalizada de nuevas tecnologías, se han conjugado para obligar a una reflexión profunda de las instituciones responsables de formación especializada. En las Universidades se plantean al menos tres niveles educativos: el grado, los posgrados, y la educación continua o permanente que involucre conocimientos teórico-prácticos y metodológicos, que contribuya a mejorar el desempeño y la jerarquía profesional en la línea de conocimientos "just in time", y que habilite a niveles superiores de conocimiento y a la investigación disciplinaria. Se define y caracteriza la eduación permanente como fenómeno educativo. Se relata el proceso de institucionalización de la Educación Permanente en la Universidad de la República y en la Escuela Universitaria de Bibliotecología y Ciencias Afines en particular. Se desarrollar criterios y políticas académicos, formas de financiación del programa, su evaluación y su proección a futuro. Se presentan datos estadísticos sobre cursos, profesores, y participantes en el período 1994-2001 en la EUBCA     

  5. Custo-efetividade da escovação dental supervisionada convencional e modificada na prevenção da cárie em molares permanentes de crianças de 5 anos de idade Cost-effectiveness of conventional and modified supervised toothbrushing in preventing caries in permanent molars among 5-year-old children

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    Paulo Frazão

    2012-02-01

    Full Text Available O custo-efetividade de um programa modificado de escovação dental supervisionada foi comparado ao programa convencional. Participaram 284 crianças de 5 anos com, pelo menos, um molar permanente com a superfície oclusal irrompida/hígida. Nas unidades de controle, o programa convencional composto de atividade educativa com distribuição de escova e creme dental fluorado foi desenvolvido quatro vezes por ano. Nas unidades de teste, as crianças receberam também escovação profissional nas superfícies oclusais desses dentes, realizada por auxiliar de saúde bucal, empregando-se a técnica de escovação vestíbulo-lingual cinco vezes por ano. Cárie de esmalte/dentina foi registrada nas superfícies vestibular, oclusal e lingual dos molares permanentes durante 18 meses. A razão da densidade de incidência (RDI foi estimada usando o modelo de regressão de Poisson, sendo 50% menor entre os meninos no grupo de teste (p = 0,016. O programa modificado custou R$ 3,04 por criança. A razão de custo-efetividade marginal foi de R$ 10,71 por lesão evitada entre os meninos. O programa modificado foi custo-efetivo nos meninos.The cost-effectiveness of a modified supervised toothbrushing program was compared to a conventional program. A total of 284 five-year-old children presenting at least one permanent molar with emerged/sound occlusal surface participated. In the control group, oral health education and dental plaque dying followed by toothbrushing with fluoride dentifrice was carried outfour times per year. With the test group, children also underwent professional cross-brushing on surfaces of first permanent molar rendered by a dental assistant five times per year. Enamel/dentin caries were recorded on buccal, occlusal and lingual surfaces of permanent molars for a period of18 months. The incidence density (ID ratio was estimated using Poisson's regression model. The ID was 50% lower among boys in the test group (p = 0.016. The cost of the

  6. Apoio Institucional Paideia como estratégia para educação permanente em saúde

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    Cristiane Pereira de Castro

    Full Text Available Trata-se de uma pesquisa-intervenção do tipo apoio. Nesta investigação, avaliaram-se os efeitos do curso-intervenção Cogestão da Clínica Ampliada e Compartilhada, especialmente no que se refere à incorporação de saberes que auxiliam os profissionais a desenvolverem a capacidade de trabalhar em rede, em equipe e com cogestão do trabalho em saúde. O curso foi oferecido aos profissionais que compunham as equipes do Centro de Saúde Aeroporto e do Centro de Atenção Psicossocial David Capistrano e a apoiadores institucionais do Distrito Sudoeste de Campinas, São Paulo. Para a produção de dados, utilizaram-se duas técnicas: observação e realização de grupos focais de avaliação com os profissionais que participaram do curso. Constataram-se mudanças relevantes nos profissionais no que diz respeito às dimensões clínica, político-institucional e do governo de si mesmos.

  7. Movements of permanent health education triggered by the training of facilitators Movimientos de la educación permanente en salud desencadenados a partir de la formación de facilitadores Movimentos da educação permanente em saúde, desencadeados a partir da formação de facilitadores

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    Cinira Magali Fortuna

    2011-04-01

    Full Text Available This study mapped the movements of Permanent Health Education in the region of Araraquara, São Paulo, Brazil, begun by the Permanent Health Education Facilitators program, promoted by the Ministry of Health and the National School of Public Health. This qualitative study was grounded on the theoretical framework of institutional and schizoanalysis. Data were collected from operative groups of individuals who finished the program. The results were grouped into two plans: micropolitics and organization. Micropolitics indicates the production of different concepts concerning permanent education and different ways to establish it. Autonomy and control and also a tenuous relationship between tutorship and autonomy were highlighted, in the plan of organization. In conclusion, the program was an important device that suffered captures/overcoding but also produced changes in practice.Se tuvo por objetivo cartografiar los movimientos de educación permanente en salud, en la región de Araraquara, Sao Paulo, Brasil, iniciados a partir del curso de Facilitadores de Educación Permanente en Salud, del Ministerio de la Salud y Escuela Nacional de Salud Pública. Es un estudio de abordaje cualitativo, sustentado por el referencial teórico del análisis institucional en la línea esquizoanalítica, siendo los datos recolectados mediante grupos operativos con alumnos terminando el referido curso. Los resultados fueron agrupados en dos planos: micropolítica y organización. Con relación a la micropolítica, apuntan que hubo producción de diferentes conceptos sobre educación permanente y diferentes formas de institucionalización de la misma. En el plano de la organización se destacan la autonomía y el control y también la tenue relación entre tutela y autonomía. Concluimos que el curso fue un importante dispositivo que sufrió capturas, pero también produjo cambios en las prácticas.Tem-se, aqui, por objetivo, cartografar os movimentos de educa

  8. Educação permanente: instrumento de trabalho do enfermeiro na instituição de longa permanência

    OpenAIRE

    Silva, Bárbara Tarouco da; Barlem, Edison Luiz Devos; Lunardi, Valeria Lerch; Santos, Silvana Sidney Costa

    2008-01-01

    A questão educacional na enfermagem é ampla, podendo referir-se à educação formal em cursos técnicos, de graduação e de pós-graduação, ou à educação em saúde voltada aos treinamentos em serviço. Ante a problemática do envelhecimento populacional, as características da sociedade moderna e o uso crescente de Instituições de Longa Permanência (ILPs) como residência dos idosos, a proposta deste texto reflexivo é enfatizar a relevância e necessidade da educação permanente para os trabalhadores que...

  9. REFORMAS EDUCATIVAS Y FORMACIÓN PERMANENTE DEL PROFESORADO EN LA ÚLTIMA OBRA DE JULIA VARELA: MEMORIA Y OLVIDO

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    Alberto Luís Gómez

    2009-01-01

    Full Text Available En este artículo se analizan la complejidad del proceso de construcción de los Centros de Profesores y el papel desempeñado por una diversidad de instancias y personas que, desde distintos puntos de vista, defendieron su articulación dentro del más amplio campo de la formación permanente del profesorado español entre 1983 y 1990. Habiendo tomado como punto de partida de nuestras reflexiones el último libro de Julia Varela ¿Las reformas educativas a debate (1982-2006¿ defendemos tanto su interés como la asimetría existente entre la relevancia política de esta obra y su debilidad historiográfica.

  10. Estudo comparativo entre ensino presencial e a distância para educação permanente de profissionais auxiliares e técnicos de enfermagem

    OpenAIRE

    Silva, Adriane das Neves

    2014-01-01

    As mudanças ocorridas no mundo do trabalho têm exigido do profissional atualização constante de saberes que possibilitem o desenvolvimento de atitude crítico-reflexiva. Este estudo buscou analisar a aplicabilidade das tecnologias da informação e da comunicação na Educação Permanente dos profissionais auxiliares e técnicos de Enfermagem em um hospital público municipal. É um estudo do tipo ensaio clínico, que lançou mão de técnicas quantitativas e qualitativas através de um experimento que oco...

  11. Deformación permanente de materiales granulares en pavimentos flexibles: estado del conocimiento Permanent strain of granular materials in flexible pavements: state of the art

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    Hugo Alexánder Rondón

    2009-01-01

    Full Text Available Diversos estudios han sido desarrollados en el área de los pavimentos para comprender el comportamiento elastoplástico que experimentan materiales granulares bajo carga cíclica. Este es el segundo de dos artículos que presentan el estado del conocimiento de investigaciones desarrolladas en esta área. Basado en una amplia revisión bibliográfica, este artículo da cuenta de la forma como ha sido estudiado el fenómeno de deformación permanente en materiales granulares empleados para conformar capas de base y sub-base de estructuras de pavimentos flexibles. Además, se exponen y se discuten los factores que afectan la resistencia a la deformación permanente y la evolución de las ecuaciones matemáticas desarrolladas para predecir la deformación que experimentan estos materiales bajo carga cíclica. Un estado del conocimiento sobre el comportamiento resiliente de estos materiales es presentado en el primer artículo (Rondón y Reyes, 2007.Several studies have been conducted in pavement field for trying to understand the elastoplastic behavior experienced by granular materials under a cyclic load. This is the second out of two articles which show state-of-the-art of researches conducted in this field. Based on a wide literature review, this article accounts for the way how permanent strain phenomenon has been studied in granular materials used for creating base and sub-base layers of flexible pavement structures. Besides, this article displays and discusses factors which affect resistance to permanent strain and evolution of mathematical equations developed for predicting that strain experienced by these materials under a cyclic load. A state-of-the-art about resilient behavior of these materials has been presented in the first article (Rondón and Reyes, 2007.

  12. Fórum Permanente da Agenda 21 Paraná: seus vínculos com o processo de mobilização social

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    Myrian Del Vecchio De Lima

    2016-12-01

    Full Text Available Este artigo utiliza a construção dos vínculos entre públicos envolvidos, proposta por Márcio Simeone Henriques (2004, para analisar a ocorrência de um processo de mobilização social, conforme entendimento teórico do sociólogo Bernardo Toro. O trabalho realiza esta proposta especificamente em relação às ações desenvolvidas pelo Fórum Permanente da Agenda 21 no Paraná. O objetivo é observar, por meio dos critérios dos vínculos, as ações de caráter mobilizador com relação a questões socioambientais empreendidas por esse coletivo, a partir do entendimento dos dois autores citados. Para tanto, o texto reflete sobre a compreensão do conceito central em questão, a mobilização social, e o papel da comunicação nesse processo. Após uma breve apresentação do Fórum Permanente da Agenda 21, verifica-se por meio de análise de conteúdo se há, no interior deste coletivo, vínculos que permitam atos de comunicação propícios à mobilização social em torno das diretrizes socioambientais propostas pela Agenda para orientar as políticas públicas.DOI: http://dx.doi.org/10.21882/ruc.v4i7.655 Recebido: 19/09/2016 Publicado: 07/12/2016

  13. NOS3 Polymorphisms and Chronic Kidney Disease

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    Alejandro Marín Medina

    2018-05-01

    Full Text Available ABSTRACT Chronic kidney disease (CKD is a multifactorial pathophysiologic irreversible process that often leads to a terminal state in which the patient requires renal replacement therapy. Most cases of CKD are due to chronic-degenerative diseases and endothelial dysfunction is one of the factors that contribute to its pathophysiology. One of the most important mechanisms for proper functioning of the endothelium is the regulation of the synthesis of nitric oxide. This compound is synthesized by the enzyme nitric oxide synthase, which has 3 isoforms. Polymorphisms in the NOS3 gene have been implicated as factors that alter the homeostasis of this mechanism. The Glu298Asp polymorphisms 4 b/a and -786T>C of the NOS3 gene have been associated with a more rapid deterioration of kidney function in patients with CKD. These polymorphisms have been evaluated in patients with CKD of determined and undetermined etiology and related to a more rapid deterioration of kidney function.

  14. Low shear stress induces vascular eNOS uncoupling via autophagy-mediated eNOS phosphorylation.

    Science.gov (United States)

    Zhang, Jun-Xia; Qu, Xin-Liang; Chu, Peng; Xie, Du-Jiang; Zhu, Lin-Lin; Chao, Yue-Lin; Li, Li; Zhang, Jun-Jie; Chen, Shao-Liang

    2018-05-01

    Uncoupled endothelial nitric oxide synthase (eNOS) produces O 2 - instead of nitric oxide (NO). Earlier, we reported rapamycin, an autophagy inducer and inhibitor of cellular proliferation, attenuated low shear stress (SS) induced O 2 - production. Nevertheless, it is unclear whether autophagy plays a critical role in the regulation of eNOS uncoupling. Therefore, this study aimed to investigate the modulation of autophagy on eNOS uncoupling induced by low SS exposure. We found that low SS induced endothelial O 2 - burst, which was accompanied by reduced NO release. Furthermore, inhibition of eNOS by L-NAME conspicuously attenuated low SS-induced O 2 - releasing, indicating eNOS uncoupling. Autophagy markers such as LC3 II/I ratio, amount of Beclin1, as well as ULK1/Atg1 were increased during low SS exposure, whereas autophagic degradation of p62/SQSTM1 was markedly reduced, implying impaired autophagic flux. Interestingly, low SS-induced NO reduction could be reversed by rapamycin, WYE-354 or ATG5 overexpression vector via restoration of autophagic flux, but not by N-acetylcysteine or apocynin. eNOS uncoupling might be ascribed to autophagic flux blockade because phosphorylation of eNOS Thr495 by low SS or PMA stimulation was also regulated by autophagy. In contrast, eNOS acetylation was not found to be regulated by low SS and autophagy. Notably, although low SS had no influence on eNOS Ser1177 phosphorylation, whereas boosted eNOS Ser1177 phosphorylation by rapamycin were in favor of the eNOS recoupling through restoration of autophagic flux. Taken together, we reported a novel mechanism for regulation of eNOS uncoupling by low SS via autophagy-mediated eNOS phosphorylation, which is implicated in geometrical nature of atherogenesis. Copyright © 2018 Elsevier B.V. All rights reserved.

  15. DOENÇAS DE SUÍNOS

    OpenAIRE

    Juliana Sperotto Brum

    2013-01-01

    Esta tese envolveu o estudo de doenças de suínos, incluindo a descrição de um sarcoma granulocítico eosinofílico e surtos de intoxicação por sal. O estudo das características e frequência das doenças na população suína na região de abrangência do Laboratório de Patologia Veterinária (LPV) da Universidade Federal de Santa Maria (UFSM) foi realizado através de um estudo retrospectivo de todos os diagnósticos de necropsias. Foram separados 564 casos com diagnósticos conclusivos. A...

  16. Renal nerves and nNOS

    DEFF Research Database (Denmark)

    Kompanowska-Jezierska, Elzbieta; Wolff, Helle; Kuczeriszka, Marta

    2008-01-01

    ). This was tested by NaLoad after chronic renal denervation with and without inhibition of nNOS by S-methyl-thiocitrulline (SMTC). In addition, the acute effects of renal denervation on MABP and sodium balance were assessed. Rats were investigated in the conscious, catheterized state, in metabolic cages...... of acutely and chronically denervated rats were less than control (15% and 9%, respectively, P reduced by renal denervation (14.5 +/- 0.2 vs. 19.3 +/- 1.3 mIU/l, P reduced...... PRC (P sodium excretion six-fold, irrespective of renal denervation and SMTC. The metabolic data demonstrated that renal denervation lowered sodium balance during the first days after denervation (P

  17. Nuevos retos para el profesorado de secundaria obligatoria: formación permanente para la atención a la diversidad en las aulas (New challenges for teachers of compulsory secondary: lifelong learning for attention to diversity in the classrooms (Nouveaux défis pour le professorat de secondaire obligatoire :formation permanente pour l’attention à la diversité dans la salle de classe (Novos desafios para os professores do ensino médio obrigatório: formação permanente para a atenção à diversidade na sala de aula

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    Mar Prats

    2009-12-01

    Full Text Available La llegada reciente de alumnos inmigrantes a los centros educativos en España ha enfrentado al profesorado a nuevos retos. El presente artículo pone de manifiesto cuáles son estos nuevos retos que afrontan los docentes de la etapa de Educación Secundaria Obligatoria, ESO, a partir de sus propias voces, para conocer las necesidades formativas derivadas de esta situación educativa, con el fin de hacer propuestas de formación permanente para los docentes, como apoyo institucional en la atención de la diversidad de alumnado que coexiste en las aulas. Utilizando como método el estudio de casos múltiples hemos analizado e interpretado la información que conduce a conclusiones prácticas, con muchas posibilidades de ser tenidas en cuenta para la formación permanente de los implicados.

  18. iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat.

    Science.gov (United States)

    Fujii, Naoto; Meade, Robert D; Alexander, Lacy M; Akbari, Pegah; Foudil-Bey, Imane; Louie, Jeffrey C; Boulay, Pierre; Kenny, Glen P

    2016-02-01

    Nitric oxide synthase (NOS) contributes to sweating and cutaneous vasodilation during exercise in younger adults. We hypothesized that endothelial NOS (eNOS) and neuronal NOS (nNOS) mediate NOS-dependent sweating, whereas eNOS induces NOS-dependent cutaneous vasodilation in younger adults exercising in the heat. Further, aging may upregulate inducible NOS (iNOS), which may attenuate sweating and cutaneous vasodilator responses. We hypothesized that iNOS inhibition would augment sweating and cutaneous vasodilation in exercising older adults. Physically active younger (n = 12, 23 ± 4 yr) and older (n = 12, 60 ± 6 yr) adults performed two 30-min bouts of cycling at a fixed rate of metabolic heat production (400 W) in the heat (35°C). Sweat rate and cutaneous vascular conductance (CVC) were evaluated at four intradermal microdialysis sites with: 1) lactated Ringer (control), 2) nNOS inhibitor (nNOS-I, NPLA), 3) iNOS inhibitor (iNOS-I, 1400W), or 4) eNOS inhibitor (eNOS-I, LNAA). In younger adults during both exercise bouts, all inhibitors decreased sweating relative to control, albeit a lower sweat rate was observed at iNOS-I compared with eNOS-I and nNOS-I sites (all P exercise protocol (all P exercise bouts (all P > 0.05). We show that iNOS and eNOS are the main contributors to NOS-dependent sweating and cutaneous vasodilation, respectively, in physically active younger adults exercising in the heat, and that iNOS inhibition does not alter sweating or cutaneous vasodilation in exercising physically active older adults. Copyright © 2016 the American Physiological Society.

  19. Soil carbon and nitrogen mineralization under different tillage systems and Permanent Groundcover cultivation between Orange trees Mineralização do carbono e nitrogênio sob diferentes preparos de solo e coberturas permanentes intercalares em pomar de laranjeira

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    Elcio Liborio Balota

    2011-06-01

    Full Text Available The objective of this work was to evaluate the alterations in carbon and nitrogen mineralization due to different soil tillage systems and groundcover species for intercropped orange trees. The experiment was established in an Ultisol soil (Typic Paleudults originated from Caiuá sandstone in northwestern of the state of Paraná, Brazil, in an area previously cultivated with pasture (Brachiaria humidicola. Two soil tillage systems were evaluated: conventional tillage (CT in the entire area and strip tillage (ST with a 2-m width, each with different groundcover vegetation management systems. The citrus cultivar utilized was the 'Pera' orange (Citrus sinensis grafted onto a 'Rangpur' lime rootstock. The soil samples were collected at a 0-15-cm depth after five years of experiment development. Samples were collected from under the tree canopy and from the inter-row space after the following treatments: (1 CT and annual cover crop with the leguminous Calopogonium mucunoides; (2 CT and perennial cover crop with the leguminous peanut Arachis pintoi; (3 CT and evergreen cover crop with Bahiagrass Paspalum notatum; (4 CT and cover crop with spontaneous B. humidicola grass vegetation; and (5 ST and maintenance of the remaining grass (pasture of B. humidicola. The soil tillage systems and different groundcover vegetation influenced the C and N mineralization, both under the tree canopy and in the inter-row space. The cultivation of B. humidicola under strip tillage provided higher potential mineralization than the other treatments in the inter-row space. Strip tillage increased the C and N mineralization compared to conventional tillage. The grass cultivation increased the C and N mineralization when compared to the others treatments cultivated in the inter-row space.No presente trabalho, foi avaliada a mineralização do Carbono e Nitrogênio devido ao cultivo intercalar de diferentes coberturas permanentes em pomar de laranjeira. O experimento foi

  20. Vascular nitric oxide: Beyond eNOS

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    Yingzi Zhao

    2015-10-01

    Full Text Available As the first discovered gaseous signaling molecule, nitric oxide (NO affects a number of cellular processes, including those involving vascular cells. This brief review summarizes the contribution of NO to the regulation of vascular tone and its sources in the blood vessel wall. NO regulates the degree of contraction of vascular smooth muscle cells mainly by stimulating soluble guanylyl cyclase (sGC to produce cyclic guanosine monophosphate (cGMP, although cGMP-independent signaling [S-nitrosylation of target proteins, activation of sarco/endoplasmic reticulum calcium ATPase (SERCA or production of cyclic inosine monophosphate (cIMP] also can be involved. In the blood vessel wall, NO is produced mainly from l-arginine by the enzyme endothelial nitric oxide synthase (eNOS but it can also be released non-enzymatically from S-nitrosothiols or from nitrate/nitrite. Dysfunction in the production and/or the bioavailability of NO characterizes endothelial dysfunction, which is associated with cardiovascular diseases such as hypertension and atherosclerosis.

  1. Impacto de la rehabilitación cardiaca intrahospitalaria en pacientes con I.M.A Impact of cardiac intra-hospital rehabilitation in patients with Acute Myocardial Infarction

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    Liván Cruz Benítez

    2006-12-01

    Full Text Available Se realizó un estudio retrospectivo longitudinal y descriptivo sobre las ventajas de la aplicación de la fase 1 de la RC en el 100% de los pacientes con IMA de bajo riesgo atendidos en el periodo 2003-2004 en el Hospital General Docente ""Comandante Pinares"" en la provincia Pinar del Río. La investigación se basó en la toma de datos obtenidos en los expedientes clínicos de estos pacientes, que están archivados; donde las variables que se exploraron en las encuestas aplicadas incluyen anamnesis, examen físico, electrocardiograma, telecardiografía, aparición de complicaciones mayores y finalmente la clasificación funcional dada al alta hospitalaria. Todos los resultados demostraron las ventajas de la rehabilitación como parte esencial de la atención y terapéutica a la que deben tener acceso los pacientes con afecciones cardíacas de cualquier edad, para mejorar su calidad de vida.A retrospective, longitudinal and descriptive study was done on the advantages of applying the stage I of the RC in 100% of low-risk AMI patients assisted at Comandante Pinares General Teaching Hospital (HGCP during 2003-2004 in Pinar del Río province. The research was based on data collected from the clinical records of these patients, which are filed. The variables explored during the surveys include: anamnesis, physical examination, electrocardiogram, telecardiography, ocurrence of major complications and finally the functional classification done at hospital discharge. All results showed the rehabilitation advantages as essential part of the assistance and therapy which patients of any age and with cardiac disorders should have access to in order to improve their quality of life.

  2. End-Stage Renal Disease Outcomes among the Kaiser Permanente Southern California Creatinine Safety Program (Creatinine SureNet): Opportunities to Reflect and Improve.

    Science.gov (United States)

    Sim, John J; Batech, Michael; Danforth, Kim N; Rutkowski, Mark P; Jacobsen, Steven J; Kanter, Michael H

    2017-01-01

    The Kaiser Permanente Southern California (KPSC) creatinine safety program (Creatinine SureNet) identifies and outreaches to thousands of people annually who may have had a missed diagnosis for chronic kidney disease (CKD). We sought to determine the value of this outpatient program and evaluate opportunities for improvement. Longitudinal cohort study (February 2010 through December 2015) of KPSC members captured into the creatinine safety program who were characterized using demographics, laboratory results, and different estimations of glomerular filtration rate. Age- and sex-adjusted rates of end-stage renal disease (ESRD) were compared with those in the overall KPSC population. Among 12,394 individuals, 83 (0.7%) reached ESRD. The age- and sex-adjusted relative risk of ESRD was 2.7 times higher compared with the KPSC general population during the same period (94.7 vs 35.4 per 100,000 person-years; p creatinine measurements, only 13% had a urine study performed (32% among patients with confirmed CKD). Our study found a higher incidence of ESRD among individuals captured into the KPSC creatinine safety program. If the Chronic Kidney Disease Epidemiology Collaboration equation were used, fewer people would have been captured while improving the accuracy for diagnosing CKD. Urine testing was low even among patients with confirmed CKD. Our findings demonstrate the importance of a creatinine safety net program in an integrated health system but also suggest opportunities to improve CKD care and screening.

  3. A Origem Histórica do Conceito de Área de Preservação Permanente no Brasil

    Directory of Open Access Journals (Sweden)

    Glaucus Vinicius Biasetto Ribeiro

    2011-01-01

    Full Text Available A nossa atualidade vem sendo marcada por uma crescente preocupação com as questões ligadas ao meio ambiente e com a preservação do nosso planeta. De uma maneira geral o aquecimento global, a influência antrópica, a degradação de ambientes naturais, os processos ecológicos, a biodiversidade, a sustentabilidade, bem como a cidadania ambiental tem se tornado temas de discussão nas diversas esferas de convívio social.Dentro da história brasileira podemos identificar uma série de regramentos de caráter ambiental considerando-se como marco a Lei 4.771 de 15 de setembro de 1965, que instituiu o novo Código Florestal Brasileiro. Ao longo do presente artigo procuraremos investigar a origem da conceituação das áreas de preservação permanentes, tema alvo de grandes discussões na atualidade, tal qual surgiu e foi inserida na legislação brasileira, procurando recuperar esse aspecto específico da história do Brasil.

  4. Técnica para identificar faltas transitorias y permanentes en líneas de transmisión, utilizando la transformada Wavelet

    Directory of Open Access Journals (Sweden)

    Miguel Martínez

    2009-01-01

    Full Text Available En el presente documento, se presenta un algoritmo que permite distinguir de forma clara y precisa, las faltas transitorias de las permanentes. Adicionalmente se determina el instante de extinción del arco secundario, para así evitar o controlar de forma efectiva y segura la operación de reconexión monofásica en sistemas de transporte de energía. El método de identificación se basa en la determinación de las características de alta frecuencia que posee la señal de tensión de la fase en falta antes del despeje y de la corriente en una fase sana y las relaciona de forma independiente mediante una auto-correlación cruzada. Para el análisis de la señal y extracción de los componentes de alta frecuencia, se ha utilizado la transformada Wavelet. El algoritmo propuesto se probó en un sistema base de 380 kV, funcionando de forma correcta en todos los escenarios planteados y logrando una identificación precisa en los primeros 25 ms de la falta.

  5. Propuesta de un plan permanente de relaciones públicas para educar adolescentes sobre los riesgos que existen en las redes sociales

    Directory of Open Access Journals (Sweden)

    Gina Gilbert Toral

    2014-06-01

    redes sociales, utilizadas como un medio de comunicación altamente efectivo; hoy en día existe un notorio cambio en la manera en que los adolescentes se relacionan e interactúan entre sí, se evidencia que los niños a temprana edad adquieren dominio sobre las redes sociales y el internet en general, por lo que están expuestos a peligros de tipo psicológico, tales como: ciberbullying, sexting, grooming y morphing. Por lo antes expuesto, y con el fin de incidir de manera positiva en los adolescentes, el presente trabajo de investigación propone la creación de un plan permanente de relaciones públicas, que entre otras actividades conlleva: charlas de psicología, talleres de concientización, la elaboración de un código de conducta online que minimice los riesgos, y finalmente el desarrollo de campañas en internet y medios tradicionales.

  6. Perspectivas de las Tecnologías de la Información y las Comunicaciones en la formación permanente del profesorado universitario

    Directory of Open Access Journals (Sweden)

    Dr. C. Oscar Antonio Martínez Molina

    2018-02-01

    Full Text Available El acelerado avance científico y tecnológico pasa por el ámbito educativo haciendo que asuma nuevos retos de elevación del nivel educativo. Las Tecnologías de la Información y las Comunicaciones en la educación proporcionan potencia, fortalecimiento y transformación en el quehacer educativo, al momento que incrementa, en la práctica docente, la calidad del servicio. En el presente artículo se exponen las herramientas tecnológicas en el uso de las TIC en la formación permanente del profesorado universitario, haciéndose una adecuada utilización de las Tecnologías de la Información y las Comunicaciones lo que marcará gran impacto en la organización, desarrollo y productos en el proceso de enseñanza-aprendizaje si se tiene en cuenta que las nuevas tecnologías de la información y de la comunicación han evolucionado espectacularmente en los últimos años, debido especialmente a su capacidad de interconexión a través de la Red. Esta nueva fase de desarrollo va a tener gran impacto en la organización de la enseñanza y el proceso de aprendizaje

  7. Usos da terra e Áreas de Preservação Permanente (APP na Bacia do Rio da Prata, Castelo-ES

    Directory of Open Access Journals (Sweden)

    Luciano Melo Coutinho

    Full Text Available Este trabalho avaliou o uso da terra e identificou Áreas de Preservação Permanente (APPs na Bacia Hidrográfica do Rio da Prata (BRP, município de Castelo-ES, via técnicas de geoprocessamento. A BRP é marcada pela supressão de vegetação nativa, para expansão da fronteira agropecuária. As classes de uso da terra foram vetorizadas por fotointerpretação de aerofotos ortorretificadas. A delimitação das APPs foi realizada a partir de dados de hidrografia e altimetria de cartas topográficas digitais, com respeito às determinações do Código Florestal Brasileiro. A principal forma de uso da terra é a agropecuária (60,84% da área total, composta pela agricultura (30,21% e pela pecuária (30,63%, sendo que a área preservada com floresta nativa é de 36,85%. As APPs representam 55,48% da área total e sua maior parte (50,40% é utilizada para fins socioeconômicos, enquanto a cobertura florestal representa apenas 49,60%.

  8. La formación inicial y permanente del profesorado de Educación Física a través del practicum

    Directory of Open Access Journals (Sweden)

    Herminia María García Ruso

    2013-05-01

    Full Text Available En este artículo se muestran los aspectos más importantes del desarrollo de un proyecto de innovación educativa realizado durante las prácticas de enseñanza. En el proyecto intervinieron cuatro alumnos, futuros maestros especialistas de Educación Física, cuatro tutoras y dos supervisoras. Trataremos de exponer, con cierto matiz descriptivo, las fases seguidas en la realización de un proyecto de investigación-acción, los objetivos formulados, la metodología empleada, la elaboración de una unidad didáctica de expresión corporal y el análisis e interpretación de la información. Finalmente, explicaremos las conclusiones que giran alrededor de tres ejes: la relación de la Universidad y los Centros Educativos, la relación del supervisor y el tutor, y la valoración del propio seminario de investigación-acción como herramienta para la investigación y la formación inicial y permanente del profesorado.

  9. As equações dos estados quase-permanentes e uma visão alternativa da indução eletromagnética

    Directory of Open Access Journals (Sweden)

    Ferreira G. F. Leal

    2001-01-01

    Full Text Available Apresenta-se o sistema de equações que descreve consistentemente os estados quase-permanentes, campos e potenciais, abrangendo a eletrostática, a magnetostática e a lei de indução de Faraday. Mostra-se que ele é correto até a ordem de v² = c² e de wr = c² em que v e w são a velocidade e a aceleração tópicas das cargas, c a velocidade da luz e r a distância ao ponto considerado. Pode-se então obter o campo elétrico de uma carga em movimento nessa aproximação, o qual corrige o campo de Coulomb por termos dependentes da velocidade e da aceleração da carga. Mostra-se assim, como feito anteriormente por Ritz e O'Rahilly, que a indução eletromagnética pode ser atribuída à aceleração das cargas do circuito indutor, propiciando uma visão alternativa dessa interação, usualmente atribuída à variação do fluxo no interior do circuito.

  10. Educação permanente em saúde: uma estratégia de gestão para pensar, refletir e construir práticas educativas e processos de trabalhos Permanent education in the healthcare field: a management strategy to think, reflect and build educational practices and work processes

    Directory of Open Access Journals (Sweden)

    Flávia Carotta

    2009-03-01

    Full Text Available Este trabalho relata a experiência de implantação da Política Nacional de Educação Permanente em Saúde (EPS, proposta pelo Ministério da Saúde (Portaria 198 de fevereiro de 2004 no município de Embu, Estado de São Paulo, Essa implantação foi adotada pela gestão municipal com o objetivo de identificar e definir ações educativas que qualifiquem a atenção e a gestão em saúde através da formação e do desenvolvimento dos trabalhadores do setor. A EPS trabalha com ferramentas que buscam a reflexão crítica sobre a prática cotidiana dos serviços de saúde, sendo, por si só, um processo educativo aplicado ao trabalho que possibilita mudanças nas relações, nos processos, nos atos de saúde e nas pessoas. Outras potencialidades dessa estratégia são: fortalecimento do controle social; repolitização do Sistema Único de Saúde (SUS; incentivo ao protagonismo de usuários e trabalhadores no processo saúde e doença e a produção de um impacto positivo sobre a saúde individual e coletiva da população.The present work reports the experience of the local authority of Embu, in the State of São Paulo, in the implementation of the National Policy of Permanent Health Education (PHE proposed by the Ministry of Health. This strategy was adopted by the municipal management with the objective of identifying and defining educational actions that qualify health care and management through the education and development of the workers of the sector. PHE works with tools that aim at the critical reflection on the daily practice of the health services, being an educational process applied to work that enables changes in the relations, processes, healthcare practices and persons. Other potentialities of this strategy are: strengthening of social control; re-politicization of the Brazilian public health system (SUS; stimulation to the leading role of users and workers in the health and disease process; and production of a positive impact

  11. Estrategias del Teatro del Oprimido para la formación permanente del profesorado (Strategies from the Theatre of the Oppressed for Permanent Training of Teaching Staff (Stratégies du théâtre de l'opprimé pour la formation permanente du corps d'enseignants (Estratégias do teatro do oprimido para a formação permanente do professorado

    Directory of Open Access Journals (Sweden)

    Tomás Motos-Teruel

    2012-06-01

    Full Text Available ResumenEste artículo relata una experiencia y su valoración de forma- ción permanente del profesorado basada en el aprendizaje vi- vencial utilizando como estrategia metodológica el Teatro del Oprimido (TO para estimular y favorecer la reflexión sobre la práctica educativa. Sus objetivos básicos fueron dar a conocer la formulación teórica y la metodología del TO y hacer la trans- ferencia de las estrategias metodológicas vivenciadas a la práctica docente. El estudio se ha planteado desde una óptica cualitativa con el estudio de caso único. Y como resultados más destacables hay que reseñar el interés y la percepción de la utili- dad personal y profesional del TO como instrumento de reflexión sobre la acción y generador de clima positivo. El Teatro del Opri- mido es una formulación teórica y un método estético cuya teo- ría y praxis están inspiradas en la Pedagogía del Oprimido de Paulo Freire, utiliza las técnicas dramáticas como un instrumen- to eficaz para la comprensión y la búsqueda de alternativas a problemas sociales, interpersonales e individuales.AbstractThis paper describes an experience and its as- sessment for application in permanent training of teaching staff, based on experiential learning and using the Theatre of the Oppressed (TO to stimu- late the thought about educational practice. The principal aims were to bring to the attention the theory and methodology of TO and to transfer its experiential methodological strategies to educa- tion practice. The study was designed as a quali- tative analysis of a single case study. The principal results include the interest and perception of use- fulness both at personal and professional levels, of TO as an instrument of thought and a generator of positive environments. The Theatre of the Oppres- sed is a theoretic concept and aesthetic method, the theory and praxis of which are inspired by Paulo Freire's Pedagogy of the Oppressed. It uses dra- ma techniques as

  12. NOS CO-OPS Water Level Data, Verified, High Low

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has verified (quality-controlled), daily, high low water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and Services...

  13. NOS CO-OPS Active Currents Data, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has surface Active Currents data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These raw data have not...

  14. NOS CO-OPS Water Level Data, Verified, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has verified (quality-controlled), 6-minute, water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS)....

  15. NOS CO-OPS Water Level Data, Preliminary, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has recent, preliminary (not quality-controlled), 6-minute, water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and...

  16. NOS CO-OPS Meteorological Data, Relative Humidity, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Relative Humidity data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not...

  17. NOAA NOS SOS, EXPERIMENTAL, 1853-present, Air Temperature

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have air temperature data. *These services are for testing and evaluation...

  18. NOAA NOS SOS, EXPERIMENTAL, 1853-present, Barometric Pressure

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have barometric pressure data. *These services are for testing and...

  19. NOAA NOS SOS, EXPERIMENTAL, 1853-present, Water Temperature

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have water temperature data. *These services are for testing and evaluation...

  20. NOAA/NOS and USCGS Seabed Descriptions from Hydrographic Surveys

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA/NOS and USCGS Seabed Descriptions from Hydrographic Surveys database is a compilation of surficial sediment composition from multiple sources for over...

  1. NOS CO-OPS Water Level Data, Verified, Hourly

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has verified (quality-controlled), hourly, water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS)....

  2. NOS CO-OPS Meteorological Data, Rain Fall, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Rain Fall data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not been...

  3. NOAA NOS SOS, EXPERIMENTAL, 1853-present, Water Level

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have water surface height above a reference datum. *These services are for...

  4. NOS CO-OPS Meteorological Data, Wind, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Wind data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not been subjected...

  5. NOS CO-OPS Meteorological Data, Air Temperature, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Air Temperature data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not...

  6. NOS CO-OPS Meteorological Data, Visibility, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Visibility data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not been...

  7. NOS CO-OPS Meteorological Data, Conductivity, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Conductivity data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not been...

  8. NOS CO-OPS Meteorological Data, Water Temperature, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Water Temperature data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not...

  9. NOS CO-OPS Meteorological Data, Barometric Pressure, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Barometric Pressure data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not...

  10. NOS CO-OPS Water Level Data, Preliminary, 1-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has recent, preliminary (not quality-controlled), 1-minute, water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and...

  11. Resíduos biológicos nos Institutos de Medicina Legal de Goiás: implicações para os trabalhadores

    Directory of Open Access Journals (Sweden)

    Izildinha Pedreira Barros

    2006-12-01

    Full Text Available Os objetivos deste estudo foram identificar o manejo dos resíduos biológicos nos Institutos de Medicina legal, segundo as diferentes etapas previstas na legislação nacional vigente; verificar a situação de risco biológico ocupacional para os trabalhadores dos Institutos de Medicina Legal (IML do Estado de Goiás A coleta de dados foi realizada por meio de observação direta, entrevista e questionário com os trabalhadores. Apesar desses serviços gerarem resíduos semelhantes ao de qualquer instituição de saúde, estes não são segregados, acondicionados e dispostos conforme as normas legais vigentes. O manejo de perfurocortantes foi o principal risco para o trabalhador, gerando exposição percutânea. Embora, haja uma consciência, entre os trabalhadores, acerca do risco biológico envolvido em suas atividades, há baixa adesão às medidas de proteção. A maioria não usa os equipamentos de proteção individual recomendados, e não têm esquema completo para as vacinas contra o vírus da hepatite B e contra o tétano. Os resultados mostram a ausência de uma política voltada para o gerenciamento dos resíduos biológicos nos IML, a vulnerabilidade dos profissionais quanto aos riscos com material biológico e a premente necessidade de educação permanente em relação às medidas de biossegurança.

  12. Resíduos biológicos nos institutos de medicina legal de Goiás: implicações para os trabalhadores

    Directory of Open Access Journals (Sweden)

    Izildinha Pedreira Barros

    2006-12-01

    Full Text Available Os objetivos deste estudo foram identificar o manejo dos resíduos biológicos nos Institutos de Medicina legal, segundo as diferentes etapas previstas na legislação nacional vigente; verificar a situação de risco biológico ocupacional para os trabalhadores dos Institutos de Medicina Legal (IML do Estado de Goiás A coleta de dados foi realizada por meio de observação direta, entrevista e questionário com os trabalhadores. Apesar desses serviços gerarem resíduos semelhantes ao de qualquer instituição de saúde, estes não são segregados, acondicionados e dispostos conforme as normas legais vigentes. O manejo de perfurocortantes foi o principal risco para o trabalhador, gerando exposição percutânea. Embora, haja uma consciência, entre os trabalhadores, acerca do risco biológico envolvido em suas atividades, há baixa adesão às medidas de proteção. A maioria não usa os equipamentos de proteção individual recomendados, e não têm esquema completo para as vacinas contra o vírus da hepatite B e contra o tétano. Os resultados mostram a ausência de uma política voltada para o gerenciamento dos resíduos biológicos nos IML, a vulnerabilidade dos profissionais quanto aos riscos com material biológico e a premente necessidade de educação permanente em relação às medidas de biossegurança.

  13. eNOS-uncoupling in age-related erectile dysfunction

    OpenAIRE

    Johnson, JM; Bivalacqua, TJ; Lagoda, GA; Burnett, AL; Musicki, B

    2011-01-01

    Aging is associated with ED. Although age-related ED is attributed largely to increased oxidative stress and endothelial dysfunction in the penis, the molecular mechanisms underlying this effect are not fully defined. We evaluated whether endothelial nitric oxide synthase (eNOS) uncoupling in the aged rat penis is a contributing mechanism. Correlatively, we evaluated the effect of replacement with eNOS cofactor tetrahydrobiopterin (BH4) on erectile function in the aged rats. Male Fischer 344 ...

  14. Genetic Ancestry Is not Associated with Breast Cancer Recurrence or Survival in U.S. Latina Women Enrolled in the Kaiser Permanente Pathways Study.

    Science.gov (United States)

    Engmann, Natalie J; Ergas, Isaac J; Yao, Song; Kwan, Marilyn L; Roh, Janise M; Ambrosone, Christine B; Kushi, Lawrence H; Fejerman, Laura

    2017-09-01

    Background: The U.S. Hispanic/Latino population is heterogeneous both socioculturally and by the proportion of European, Indigenous American, and African ancestry of the regions from which individuals originate. A previous study reported that genetic ancestry was associated with breast cancer survival among Latinas, independent of sociodemographic and tumor characteristics, suggesting that a genetic factor associated with ancestry may affect breast cancer survival. Methods: We evaluated the association of genetic ancestry with breast cancer outcomes among 506 Latina women with invasive breast cancer in the Pathways Study, a cohort study within Kaiser Permanente, an integrated health care delivery system. Proportional hazards models were used to assess the effect of ancestry on breast cancer recurrence (53 events), breast cancer-specific mortality (31 events) and all-cause mortality (54 events), with a mean follow-up time of 6 years. Results: Indigenous American ancestry was not associated with breast cancer recurrence [HR = 1.00 per 10% increase; 95% confidence interval (CI), 0.86-1.16], breast cancer mortality (HR = 0.95; 95% CI, 0.77-1.17), or all-cause mortality (HR = 0.93; 95% CI, 0.80-1.08). Adjustment for sociodemographic variables, tumor characteristics, and treatment did not alter the associations. Conclusions: Our results suggest that previously reported differences in breast cancer survival by genetic ancestry may be overcome by improving health care access and/or quality. Impact: Improving health care access and quality may reduce breast cancer disparities among U.S. Latinas. Cancer Epidemiol Biomarkers Prev; 26(9); 1466-9. ©2017 AACR . ©2017 American Association for Cancer Research.

  15. Contação de história: tecnologia cuidativa na educação permanente para o envelhecimento ativo

    Directory of Open Access Journals (Sweden)

    Nadia Pinheiro da Costa

    Full Text Available RESUMO Objetivo: avaliar pertinência e efetividade da tecnologia cuidativo-educacional "contação de histórias" como estratégia no cultivo do envelhecimento ativo (EA para usuários idosos de uma Unidade Básica de Saúde (UBS, da Amazônia. Método: Pesquisa Convergente Assistencial (PCA, realizada em UBS de Belém, estado do Pará, com oito idosas para testagem da tecnologia. Aplicou-se questionário de avaliação do EA e WHOQOL - breve, avaliação de qualidade de vida. Após capacitação com vistas à educação permanente, idosas contaram histórias para uma plateia que se manifestou respondendo à pergunta: "O que você tirou dela para a sua vida?" Resultados: histórias populares contadas provocaram reações das quais emergiram as categorias: Solidariedade; Respeito ao outro; Imaginação, sonhos, esperança e Cultura do imaginário amazônida. Tal prática resultou positiva, com mudança na qualidade de vida das idosas, no domínio psicológico. Conclusão: "contação de histórias" revelou-se uma tecnologia inovadora, recurso pertinente e efetivo à educação em saúde, especialmente para o envelhecimento ativo.

  16. Diversidad y carbono almacenado en el área forestal permanente de Álvaro Obregón, Calakmul, Campeche

    Directory of Open Access Journals (Sweden)

    Ligia Guadalupe Esparza Olguín

    2018-01-01

    Full Text Available El Área Forestal Permanente (AFP del ejido Álvaro Obregón en Calakmul resguarda selvas subperennifolias que han estado expuestas al manejo forestal. Dada su importancia como reservorios de carbono y biodiversidad, el objetivo de este estudio fue analizar la diversidad arbórea, la acumulación de biomasa y la captura de carbono en diferentes comunidades de dicho tipo de vegetación (selva mediana – SMSP y selva inundable - SI presentes en el AFP, las cuales están en periodo de recuperación desde hace más de 20 años. El trabajo se realizó en parcelas circulares de 1 000 m2, en donde se etiquetaron, midieron (altura y diámetro a la altura de 1.30 m, e identificaron los taxa arbóreos presentes. En las SMSP se determinó una riqueza de 90 especies, con densidades de 5 170 y 3 720 ind ha-1, con una diversidad (H intermedia (2.8 a 2.65. En las SI se identificaron 75 especies, con una densidad (5 920 a 8 630 ind ha-1, y una diversidad (H alta (3.02 a 3.06. La diversidad estructural promedio (Hsdh fue baja para SMSP y SI, con valores de carbono de 16.6 a 37.17 Mg C ha-1, en SMSP; y 36.44 a 44.58 en SI. Se concluye que las selvas subperennifolias analizadas están en recuperación, con procesos de regeneración y captura de carbono importantes para la conservación de la diversidad.

  17. Estimación de la carga de enfermedad por incapacidad laboral permanente en España durante el período 2009-2012

    Directory of Open Access Journals (Sweden)

    María Andrée López

    2014-01-01

    Full Text Available Fundamentos: La incapacidad laboral permanente (IP supone una importante carga social y económica. El objetivo de este estudio fue estimar la carga de enfermedad debida a la IP en España. Métodos: A partir de la Muestra Continua de Vidas Laborales (MCVL se imputó como diagnóstico de la IP (2009-2012 el de la incapacidad temporal (IT iniciada en 2009 en los individuos que cumplieron dos criterios: larga duración de la IT y corta duración del período entre la IT y la IP. Para los casos con diagnóstico imputado se calculó la carga de enfermedad por IP a partir de los años potenciales de vida laboral perdidos (APVLP, definidos como la diferencia entre la edad de jubilación (65 años y la edad de inicio de la IP. Resultados: Según la MCVL, 163.135 (13,6% personas sufrieron de IT en 2009, de las cuáles a 4.738 (0,39% se le reconoció una IP entre 2009-2012. Se pudo establecer el diagnóstico de IP en 3.073 (64,9% casos. Las causas más frecuentes de IP fueron los trastornos musculo-esqueléticos (27,4% y mentales (11,6% que, asimismo, produjeron mayor cantidad de APVLP por IP: 11.086 (26,5% y 7.052 (16,9%, respectivamente. Los trastornos mentales destacaron por producir IP a edades más jóvenes (mediana=49 años. Conclusiones: Los trastornos mentales y los musculo-esqueléticos representaron la mayor carga de enfermedad en individuos en situación de IP.

  18. Role of iNOS and eNOS expression in a group of Egyptian diabetic and nondiabetic nephropathy patients

    Directory of Open Access Journals (Sweden)

    Mayssa I. Aly

    2013-01-01

    Conclusion The presence of iNOS is associated with tubular damage resulting in renal failure. The upregulation of NO in diabetes mellitus type 2 may explain the endothelial dysfunction that is associated with almost all diabetic complications.

  19. Analysis of land use and occupancy in permanent preservation areas according to the hydrography of Ribeirão Água Fria - Bofete, SP - Brazil Análise do uso e ocupação do solo em áreas de preservação permanente, segundo a hidrografia do Ribeirão Água Fria - Bofete - SP

    Directory of Open Access Journals (Sweden)

    Rafael C. Nardini

    2012-10-01

    '30" de latitude sul com uma área de 15.242,84 ha. O mapa de uso do solo foi elaborado por meio da interpretação diretamente na tela do computador de imagem digital de satélite. Nos dados orbitais, a área de estudo está inserida no quadrante A, da imagem TM/Landsat-5, órbita 220, ponto 76, passagem de 8/09/2007. O Sistema de Informação Geográfica empregado foi o Cartalinx. As áreas de conflito da microbacia foram obtidas a partir do cruzamento entre os mapas de uso do solo e de APPs. Os resultados permitiram concluir que mais da metade da área (51,09% está ocupada por pastagens, reflexo de solos arenosos e de baixa fertilidade. Constatou-se, ainda, que apesar de quase metade da microbacia estar coberta com algum tipo de vegetação (48,78% de mata natural/reflorestamento, possui aproximadamente um terço das áreas de preservação permanente utilizadas inadequadamente por pastagens (88,15%, reflorestamento (10,42% e solo exposto (1,43%, totalizando 343,07 ha de áreas conflitantes em um total de 993,26 ha de APPs.

  20. IMA Genome-F 5G

    OpenAIRE

    Wingfield, Brenda D.; Barnes, Irene; Wilhelm de Beer, Z.; De Vos, Lieschen; Duong, Tuan A.; Kanzi, Aquillah M.; Naidoo, Kershney; Nguyen, Hai D.T.; Santana, Quentin C.; Sayari, Mohammad; Seifert, Keith A.; Steenkamp, Emma T.; Trollip, Conrad; van der Merwe, Nicolaas A.; van der Nest, Magriet A.

    2015-01-01

    The genomes of Ceratocystis eucalypticola, Chrysoporthe cubensis, Chrysoporthe deuterocubensis, Davidsoniella virescens, Fusarium temperatum, Graphilbum fragrans, Penicillium nordicum and Thielaviopsis musarum are presented in this genome announcement. These seven genomes are from plant pathogens and otherwise economically important fungal species. The genome sizes range from 28 Mb in the case of T. musarum to 45 Mb for Fusarium temperatum. These genomes include the first reports of genomes f...

  1. Saag käima! / Laurence Lumiere

    Index Scriptorium Estoniae

    Lumiere, Laurence

    2006-01-01

    Tallinnas on ekraanil õudusfilm "Texase mootorsaemõrvad : algus" ("The Texas Chainsaw Massacre : The Beginning") : režissöör Jonathan Liebesman : Ameerika Ühendriigid 2006. Ülevaade sama teema ja pealkirjaga rohketest eelkäijatest kuni esimeseni - 1974.a. valminud Tobe Hooperi filmini "Texase mootorsaemõrvad"

  2. IMA RESERVISTS: MISSION ENHANCEMENTS OR ADMINISTRATIVE BURDENS

    Science.gov (United States)

    2015-11-01

    experience and brings corporate ideas into the military environment. Statistically , the average age of a Reserve officer is 41, and the average enlisted...the RIO. However, in the event these items become delinquent , both the Active Duty unit and Reserve Detachment are responsible for enforcing... delinquent . It is well understood that keeping an Active Duty unit roster deployment ready is a time-intensive task. In July 2014, the Air Force

  3. R-ES-ONANCE--IMa-rc-h

    Indian Academy of Sciences (India)

    English language appears in Shakespeare where he mockingly and ... Understanding the laws of Energy ... physics with the advent of quantum of engineers ... of sources and suggested reading, arranged chapter-wise. ... engineering career.

  4. RE-SONANCE--IMa-rc-h

    Indian Academy of Sciences (India)

    are thought of. Some people still do not agree with the ... does it matter as to what scheme is used, it is the same for allf" ... interview or a traditional short answer test. While some .... candidate can have a strategy of randomly guessing out.

  5. R-ES-ONANCE--IMa-rc-h

    Indian Academy of Sciences (India)

    in South American rain forests to the human body and right upto the working of the planet itself. ... parts, the similarities and differences between the realm of living and ... such as the development of plants and animals from embryo to adult, the ...

  6. ES-ONANC-.E--IMaY

    Indian Academy of Sciences (India)

    with equal feliCity apply a grammatical dictum to the same purpose. Sundararaja , a contemporary. Tamil astronomer, refers to Nllakal)!ha as facf - darshani - piirangata , one who had mastered the six systems of Indian philosophy. Another major work of Nllakar:ttha is his 8ho~a on Aryabhatiyam of. Aryabhata (476 A.D).

  7. R-ES-ONANCE--IMaY

    Indian Academy of Sciences (India)

    judae. This association cannot be a general phenomenon because one can notice several guava trees ... I have little idea about insect behaviour. At the end it is clear to me that readers are agreed with my observations but they are not satisfied ...

  8. Melanoma NOS1 expression promotes dysfunctional IFN signaling.

    Science.gov (United States)

    Liu, Qiuzhen; Tomei, Sara; Ascierto, Maria Libera; De Giorgi, Valeria; Bedognetti, Davide; Dai, Cuilian; Uccellini, Lorenzo; Spivey, Tara; Pos, Zoltan; Thomas, Jaime; Reinboth, Jennifer; Murtas, Daniela; Zhang, Qianbing; Chouchane, Lotfi; Weiss, Geoffrey R; Slingluff, Craig L; Lee, Peter P; Rosenberg, Steven A; Alter, Harvey; Yao, Kaitai; Wang, Ena; Marincola, Francesco M

    2014-05-01

    In multiple forms of cancer, constitutive activation of type I IFN signaling is a critical consequence of immune surveillance against cancer; however, PBMCs isolated from cancer patients exhibit depressed STAT1 phosphorylation in response to IFN-α, suggesting IFN signaling dysfunction. Here, we demonstrated in a coculture system that melanoma cells differentially impairs the IFN-α response in PBMCs and that the inhibitory potential of a particular melanoma cell correlates with NOS1 expression. Comparison of gene transcription and array comparative genomic hybridization (aCGH) between melanoma cells from different patients indicated that suppression of IFN-α signaling correlates with an amplification of the NOS1 locus within segment 12q22-24. Evaluation of NOS1 levels in melanomas and IFN responsiveness of purified PBMCs from patients indicated a negative correlation between NOS1 expression in melanomas and the responsiveness of PBMCs to IFN-α. Furthermore, in an explorative study, NOS1 expression in melanoma metastases was negatively associated with patient response to adoptive T cell therapy. This study provides a link between cancer cell phenotype and IFN signal dysfunction in circulating immune cells.

  9. Cenários ambientais para o ordenamento territorial de áreas de preservação permanente no município de Sorocaba, SP

    Directory of Open Access Journals (Sweden)

    Kaline de Mello

    2014-04-01

    Full Text Available Este estudo objetivou analisar a importância das Áreas de Preservação Permanente (APP para a manutenção dos remanescentes florestais no município de Sorocaba, SP. O mapa desses remanescentes foi elaborado com base em fotografias aéreas de 2006, e mapas de hidrografia e de declividade foram usados para determinação das APP. Compararam-se dois cenários: real (mata atual e ideal (mata atual acrescida da restauração das APP, com base em métricas da paisagem. Os resultados indicaram que 19% do município se enquadra como APP e, dessa área, apenas 45% possui cobertura florestal. As APP preservadas representam 50% do total de cobertura florestal da paisagem. A restauração das APP representaria aumento de 16,68% para 28% de cobertura florestal da paisagem e possibilitaria o surgimento de fragmentos maiores que 3.000 ha, enquanto no cenário real os maiores fragmentos atingem 300 ha. Os remanescentes florestais se apresentaram intimamente ligados às APP: margens de rios, áreas alagáveis e encostas, onde a ocupação urbana foi dificultada e existe o instrumento legal de proteção. Esse quadro evidencia que as APP possuem papel fundamental na conservação florestal em um município bastante urbanizado, onde as áreas naturais sofrem muita pressão. A avaliação dos cenários mostrou que a incorporação dos dispositivos legais no planejamento e ordenamento territorial subsidia as estratégias voltadas para a manutenção de hábitats naturais e, consequentemente, a diminuição dos efeitos negativos sobre a biodiversidade. Entretanto, as mudanças recentes no Código Florestal podem representar um retrocesso no cenário ambiental nacional diante da crescente urbanização.

  10. Prevalencia de defectos del desarrollo del esmalte en los incisivos permanentes de escolares: un estudio fotográfico en el Sur de Brasil

    Directory of Open Access Journals (Sweden)

    Renata Barbieri Bogo

    2011-01-01

    presencia de DDE en los incisivos permanentes de los escolares en el sur de Brasil fue alta, es importante que el cirujano dentista sea capaz de diagnosticar e identificar los posibles factores etiológicos.

  11. Consumo no Brasil: teoria da renda permanente, formação de hábito e restrição à liquidez

    Directory of Open Access Journals (Sweden)

    Fábio Augusto Reis Gomes

    2004-09-01

    Full Text Available Este artigo analisa a série de consumo agregado do Brasil. Como usual, investiga-se, primeiramente, a aplicabilidade da hipótese do passeio aleatório do consumo, derivada teoricamente a partir das hipóteses de ciclo de vida/renda permanente e expectativas racionais (TRP. Utilizando a decomposição de Beveridge e Nelson (1981 verificamos que o consumo apresenta, além de uma tendência estocástica, uma parte cíclica estacionaria, o que não é compatível com a TRP. Este resultado está em conformidade com o resultado de Reis et alii (1998 de que grande parte da população brasileira está restrita a consumir sua renda corrente, existindo um ciclo comum entre consumo e renda. Em uma tentativa de gerar um processo estocástico para o consumo compatível com a evidência empírica introduzimos formação de hábito nas preferências de um consumidor representativo. No entanto, o processo daí derivado não se mostrou significativo diante da possibilidade dos consumidores serem restritos à liquidez.This article analyzes the behavior of aggregate consumption series in Brazil. As usual, the random walk hypothesis of consumption, derived theoretically from the life cycle/permanent income and rational expectations hypothesis (PIH, is tested. The Beveridge e Nelson (1981 decomposition indicates that the consumption series has a stochastic trend and a cyclical stationary component, incompatible with the PIH. This result is in line with Reis et alii (1998, who concluded that a large fraction of Brazilian people is credit constrained, which generates a common cycle between consumption and income. Following, we introduce habit formation in the preference of a representative consumer in order to attempt to produce a process of consumption compatible with the empirical evidence. However, such a process does not prove itself statistically significant amidst the possibility of credit constraint consumers.

  12. Incidence of Norovirus and Other Viral Pathogens That Cause Acute Gastroenteritis (AGE among Kaiser Permanente Member Populations in the United States, 2012-2013.

    Directory of Open Access Journals (Sweden)

    Scott P Grytdal

    Full Text Available Noroviruses and other viral pathogens are increasingly recognized as frequent causes of acute gastroenteritis (AGE. However, few laboratory-based data are available on the incidence of AGE caused by viral pathogens in the U.S. This study examined stool specimens submitted for routine clinical diagnostics from patients enrolled in Kaiser Permanente (KP health plans in metro Portland, OR, and the Maryland, District of Columbia, and northern Virginia geographic areas to estimate the incidence of viral enteropathogens in these populations. Over a one-year study period, participating laboratories randomly selected stools submitted for routine clinical diagnostics for inclusion in the study along with accompanying demographic and clinical data. Selected stools were tested for norovirus, rotavirus, sapovirus, and astrovirus using standardized real-time RT-PCR protocols. Each KP site provided administrative data which were used in conjunction with previously published data on healthcare utilization to extrapolate pathogen detection rates into population-based incidence rates. A total of 1,099 specimens collected during August 2012 to September 2013 were included. Mean age of patients providing stool specimens was 46 years (range: 0-98 years. Noroviruses were the most common viral pathogen identified among patients with AGE (n = 63 specimens, 6% of specimens tested. In addition, 22 (2% of specimens were positive for rotavirus; 19 (2% were positive for sapovirus; and 7 (1% were positive for astrovirus. Incidence of norovirus-associated outpatient visits was 5.6 per 1,000 person-years; incidence of norovirus disease in the community was estimated to be 69.5 per 1,000 person-years. Norovirus incidence was highest among children 65 years (outpatient incidence = 7.8 per 1,000 person-years; community incidence = 75.8 per 1,000 person-years. Outpatient incidence rates of rotavirus, sapovirus, and astrovirus were 2.0, 1.6, 0.6 per 1,000 person

  13. Expression analysis of NOS family and HSP genes during thermal stress in goat ( Capra hircus)

    Science.gov (United States)

    Yadav, Vijay Pratap; Dangi, Satyaveer Singh; Chouhan, Vikrant Singh; Gupta, Mahesh; Dangi, Saroj K.; Singh, Gyanendra; Maurya, Vijay Prakash; Kumar, Puneet; Sarkar, Mihir

    2016-03-01

    Approximately 50 genes other than heat shock protein (HSP) expression changes during thermal stress. These genes like nitric oxide synthase (NOS) need proper attention and investigation to find out their possible role in the adaptation to thermal stress in animals. So, the present study was undertaken to demonstrate the expressions of inducible form type II NOS (iNOS), endothelial type III NOS (eNOS), constitutively expressed enzyme NOS (cNOS), HSP70, and HSP90 in peripheral blood mononuclear cells (PBMCs) during different seasons in Barbari goats. Real-time polymerase chain reaction, western blot, and immunocytochemistry were applied to investigate messenger RNA (mRNA) expression, protein expression, and immunolocalization of examined factors. The mRNA and protein expressions of iNOS, eNOS, cNOS, HSP70, and HSP90 were significantly higher ( P goats.

  14. Suspended sediment entrainment estimation in unsteady turbulent flows by means of a stochastic meted; Computo de la incorporacion de sedimento en suspension en flujos turbulentos no permanentes utilizando un enfoque estocastico

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, Jose Fernando; Garcia, Marcelo Horacio [Universidad de Illinois (United States); Admiraal, David Mark [Universidad de Nebraska en Lincoln (United States)

    2001-06-01

    bibliografia, pero todas ellas han sido derivadas para condiciones de flujo permanente y uniforme. La bondad de estas relaciones para predecir tasas de incorporacion en flujos no permanentes no ha sido demostrada y tampoco se ha intentado desarrollar una formulacion general que sea aplicable tanto en condiciones permanentes como no permanentes. El enfoque tradicional relacionada la incorporacion de sedimento con el esfuerzo de corte asociado con la friccion de grano en una forma deterministica, proveyendo solo una relacion entre valores medios. Una alternativa es considerar el esfuerzo de corte y la incorporacion como magnitudes estocasticas turbulentas y expresarlas en terminos de sus funciones de densidad de probabilidad (PDF). De esta manera se pueden obtener estadisticos de la incorporacion a partir de las PDF del esfuerzo de corte tanto en situaciones de flujos permanentes como no permanentes, dado que el efecto de la impermanencia esta implicito en el PDF. Esta nueva metodologia fue usada para estimar la incorporacion de sedimento debido al paso de embarcaciones en los rios Mississippi e Illinois. Al usar una expansion en cumulantes de bajo orden para describir la PDF del esfuerzo de corte y una version generalizada de la relacion de incorporacion de Garcia y Parker, se obtuvo una expresion para el promedio de la incorporacion, en funcion del promedio, varianza, asimetria y kurtosis del esfuerzo de corte. Los resultados se comparan satisfactoriamente con valores mencionados en la literatura.

  15. Defectos del esmalte, caries en dentición primaria, fuentes de fluoruro y su relación con caries en dientes permanentes Enamel defects, caries in primary dentition and fluoride sources: relationship with caries in permanent teeth

    Directory of Open Access Journals (Sweden)

    Ana Alicia Vallejos-Sánchez

    2007-06-01

    Full Text Available Objetivo: Explorar la relación entre la presencia de defectos del esmalte (DE, la experiencia de caries en la dentición temporal, y la exposición a diversas fuentes de fluoruros, con la presencia de caries en la dentición permanente de niños con dentición mixta. Material y métodos: Se realizó un estudio transversal en 713 sujetos de 6-9 años de edad de 4 escuelas de Campeche, México, mediante un cuestionario dirigido a las madres, y un examen clínico bucal a los niños. La variable dependiente fue la prevalencia de caries en la dentición permanente. Resultados: El promedio de dientes temporales cariados, extraídos y obturados (ceod y dientes permanentes cariados, perdidos y obturados (CPOD fue de 2,48 (2,82 (ceod > 0 = 58,9% y 0,40 (0,98 (CPOD > 0 = 18,2%, respectivamente. El índice SiC (índice de caries significativa, calculado en la dentición temporal fue de 5,85 para los niños de 6 años de edad. En el análisis de regresión logística multivariado permanecieron significativas, después de ajustar por variables de exposición a fluoruros, la mayor edad (odds ratio [OR] = 2,99, el ceod > 0 (OR = 5,46, la menor escolaridad de la madre (OR = 1,57 y una interacción entre sexo y defectos del esmalte. Conclusiones: Las caries en la dentición temporal y permanente fueron relativamente menores que las observaciones publicadas por otros estudios en México. Los resultados confirmaron que la caries en la dentición temporal se asoció fuertemente con la caries en la dentición permanente. No hubo una relación significativa entre las fuentes de fluoruro y la caries dental en la dentición permanente.Objective: To examine the relationship between the presence of enamel defects, dental caries in primary teeth, and exposure to various fluoride technologies and the presence of dental caries in permanent teeth in children with mixed dentition. Materials and methods: A cross-sectional study was conducted in 713 children aged 6-9 years old

  16. Hacia un espacio europeo de aprendizaje para toda la vida. Evolución y desarrollo de la Educación Permanente en la Unión Europea.

    Directory of Open Access Journals (Sweden)

    Fernando López Noguero

    2008-01-01

    Full Text Available En sus inicios, la Unión Europea (UE concedió una mínima importancia a la educación en el marco de los derechos y las políticas sociales europeas, aumentando su peso paulatinamente, como comprobaremos en la propia evolución de la Educación Permanente en la UE, desarrollo que hemos dividido en cuatro etapas fundamentales. Así, desde la proclamación del Año Europeo de la Educación y la Formación Permanentes en 1996, en el que se fomentó en el seno de la UE el concepto de aprendizaje durante toda la vida, la Educación Permanente ha cambiado radicalmente en Europa hacia una nueva realidad que se ha dado en llamar “Espacio Europeo de Aprendizaje para toda la vida”, que analizamos en profundidad a través del análisis de la legislación y programas educativos existentes en la UE. ------------------------------------------------------------------------ In its early years, the European Union (EU granted a minimal importance to education in the framework of rights and social policies in Europe, increasing its weight gradually, as we Hill check on the evolution of Continuing Education in EU development which we have divided into tour Basic stages. So we will check how, since the proclamation of the European Year of Education and Training Standing in 1996, which fostered within the EU the concept of lifelong learning, Continuing Education has changed dramatically in Europe towards a new reality that has been termed a “European Area Learning for Life” which analyzed in depth through the analysis of legislation and educational programs existing in the EU.

  17. Las redes sociales en los procesos de adaptación a cambios permanentes de hábitat* Un estudio con habitantes de la Depresión Momposina (Norte de Colombia)

    OpenAIRE

    Gabriel Garrido Escudero; Camilo Madariaga

    2001-01-01

    En este artículo se describen las redes sociales durante los procesos de adaptación a los permanentes cambios que viven los pobladores de la Depresión Momposina en La Travesía, corregimiento de Mompox (Colombia). La información se recogió en una muestra de 262 personas, mediante la triangulación se compararon los resultados cuantitativos y los cuantitativos y se contrastó la información desde diversas estrategias para describir de mejor forma los fenómenos estudiados. Con ba...

  18. "Estudo in vitro do potencial cariostático dos selantes resinosos, dos cimentos ionoméricos, do diamino fluoreto de prata e do verniz fluoretado, aplicados em superfície oclusal de molares permanentes humanos".

    OpenAIRE

    Thereza Christina Lopes Coutinho

    2002-01-01

    O objetivo deste trabalho foi avaliar, in vitro, ao Microscópio de Luz Polarizada (MLP), o potencial cariostático dos selantes resinosos, dos cimentos ionoméricos, do diamino fluoreto de prata e do verniz fluoretado aplicados em superfície oclusal de molares permanentes humanos. Para tanto, 70 terceiros molares humanos hígidos, extraídos por razões clínicas, foram divididos aleatoriamente em sete grupos (N=10): GI – controle (sem selamento); GII – selante resinoso sem flúor Delton ®; G III – ...

  19. Envolvimento nos direitos humanos e sistemas de valores

    OpenAIRE

    Pereira,Cícero; Ribeiro,Ana Raquel Correia; Cardoso,Sandro José

    2004-01-01

    Com base no modelo da análise quantitativa das representações sociais, o estudo (N = 300) tratou do posicionamento de estudantes universitários em relação aos Direitos Humanos (DHs) e à ancoragem social desse posicionamento nos sistemas de valores dos estudantes. Os resultados mostram que as representações dos estudantes sobre o envolvimento nos DHs envolvem quatro princípios organizadores: pessoal-abstrato; pessoal-concreto; governamental-abstrato; governamental-concreto. Em relação à ancora...

  20. Formación del formador de personas adultas: de la realización profesional a la transformación permanente de los entornos comunitarios

    Directory of Open Access Journals (Sweden)

    Antonio MEDINA RIVILLA

    2009-11-01

    Full Text Available RESUMEN: La formación y actualización permanente es un deber y un derecho de los formadores, y un compromiso de las administraciones e instituciones educativas. Los modelos y estrategias de formación del formador se han ido adaptando a las situaciones en las que actúan los formadores. Entre los modelos que más hemos desarrollado con los formadores destacamos:El proceso de autoconocimiento e identidad profesional desde la narrativa justificada de la propia autobiografía formativa.La construcción del saber práctico.El proceso de desarrollo profesional en equipo, con apoyo entre colegas.La creación de una cultura de colaboración. Estas amplias perspectivas se complementan con la transformación de la práctica reflexiva individualizada, que facilita el avance del conocimiento profesional y la madurez formativa de los formadores.Estas perspectivas se integran en un modelo pensativo-colaborativo, fundamentado en un proceso de indagación continua y de avance del saber profesional en coherencia con las teorías implícitas de los formadores/as. El formador/a ha de encontrar las claves para diseñar su itinerario de profesionalización y vivirlo en continua mejora y diálogo con colegas, abierto a las demandas de la comunidad y a los retos -sociolaborales, necesitados de un aprendizaje a lo largo de la vida.ABSTRACT: The formation and permanent update is a duty and a right of the forming ones, and a commitment of the administrations and educational institutions. The models and strategies of formation of the forming one have been adapting to situations in which they actuate the forming ones. Among the models that more we have developed with the forming ones we stand out:The process of self-knowledge and identity professional from the narrative of the own formative autobiography.The construction of to know practically.The process of professional development in equipment, with support between colleagues.The creation of a culture of collaboration

  1. Interfaz visual para un Autocolimador Nikon 6D mediante procesamiento de imágenes con precisión sub-píxel: un caso de estudio

    Directory of Open Access Journals (Sweden)

    C. Schurrer

    2014-07-01

    Full Text Available Resumen: Este documento tiene el objetivo de describir el potencial de una interfaz visual ba'sica en un Autocolimador del tipo Nikon 6B/6D, para reemplazar al operario en una medición de calidad metrológica. La interfaz visual implementada consta de una cámara con sensor CMOS adosada al ocular del autocolimador, partes posicionales, y un sistema de procesamiento digital de imágenes propio, escrito en lenguaje Matlab OR, que analiza la imagen de la ret́ıcula para detectar la escala y la cruz de medición a nivel sub-ṕıxel. Mediante un experimento controlado, realizado con un nivel electrónico trazable internacionalmente, se obtuvieron, con este sistema, ángulos de cabeceo (αy con una resolución tres veces mejor que la del instrumento sin interfaz. Este ejemplo sugiere que el valor de 0.06 ṕıxeles para la incertidumbre asociada con la posición sub-ṕıxel de las diferentes ĺıneas que conforman la ret́ıcula de medición es realista, y permite seguir trabajando en una interfaz robusta para todos los parámetros angulares posibles de ser medidos por el autocolimador. Abstract: The goal of this paper is to describe the potential of a ba- sic visual interfase applied to a Nikon 6B/6D autocollimator in order to replace human operator within a “laboratory grade” measurement. The implemented optical interface consists of a CMOS sensor-based camera attached to the autocollimator ocu- lar, camera positioning devices and a proprietary digital image processing package, built around Matlab OR environment, used to analyze the reticle's image to detect both the scale and the measuring cross at sub-pixel level. In a controlled experiment the system performance was compared against an electronic le- vel with internationally traceable certification. Pitch angles we- re obtained with a resolution three times better than the original of the instrument. This example shows that

  2. Los medios de comunicación ¿nos igualan o nos diferencian?

    Directory of Open Access Journals (Sweden)

    Javier BALLESTA PAGÁN

    2009-05-01

    Full Text Available RESUMEN: En este artículo presentamos los resultados obtenidos en una investigación llevada a cabo en los centros educativos de Educación Secundaria Obligatoria de la Región de Murcia donde se ha pretendido valorar el equipamiento, el acceso a la información y el consumo de medios de comunicación en el hogar, por parte del alumnado inmigrante en comparación con el autóctono. Los datos aportados de dicho estudio nos confirman que la mayoría de los recursos más utilizados en el hogar es menor en los hogares del alumnado inmigrante de Educación Secundaria Obligatoria (ESO respecto al resto de la muestra en general de los alumnos. Por otra parte, el acceso a los medios, para estos alumnos inmigrantes, corrobora que son considerados recursos de gran importancia como vehículos en su acercamiento al aprendizaje y al entretenimiento. En cuanto al uso personal de dichos medios de comunicación observamos que mientras el ordenador, el móvil y el DVD son muy utilizados, comprobamos cómo desciende su uso e interés cuando abordamos otros medios de papel impreso, entre los que destacamos el libro y el periódico. Sin embargo, el uso de la televisión es bastante similar en ambos colectivos. Con relación al acceso a Internet, los resultados analizados parecen confirmar que el hogar se convierte en el lugar adecuado para su uso en ambas muestras, por encima de otros espacios públicos o privados. Sin embargo, si comprobamos la disponibilidad de acceso al mismo en el hogar por parte del alumnado inmigrante, destacamos que es menor de la que disponen los hogares autóctonos. En relación con la lectura, el nivel lector de estos jóvenes inmigrantes es también menor, aunque no existe una gran diferencia, respecto de la muestra de alumnos autóctonos. Al valorar el uso que hacen de la biblioteca comprobamos que más de la mitad de los alumnos afirman ir a ella, pero preferentemente a la pública más que la biblioteca del centro o a la de otras

  3. Las Rocas Nos Cuentan (Rocks Tell Their Stories)

    Science.gov (United States)

    Llerandi-Roman, Pablo A.

    2012-01-01

    Many Earth science lessons today still focus on memorizing the names of rocks and minerals. This led the author to develop a lesson that reveals the fascinating stories told by rocks through the study of their physical properties. He first designed the lesson for Puerto Rican teachers, hence its Spanish title: "Las Rocas Nos Cuentan Su Historia."…

  4. Pubertal development of penile Nitric Oxide Synthase (NOS ...

    African Journals Online (AJOL)

    Conclusion: The number of NADPH-positive fibers increases with age; however similar tumescence was recorded following electrostimulation in all age groups. NOS-nerve growth correlates with serum testosterone level. The increase of NADPH-positive fibers was accompanied by a decrease in the delay of onset of penile ...

  5. Biomasa microbiana y actividad ureasa del suelo en una pradera permanente pastoreada de Chile Soil microbial biomass and urease activity in a grazed permanent pasture from Chile

    Directory of Open Access Journals (Sweden)

    Pedro Antonio Núñez Ramos

    2012-12-01

    Full Text Available En los sistemas de pasturas; la productividad de la pradera puede estar influenciada por el manejo; debido a su impacto sobre los microorganismos del suelo y el reciclaje de nutrientes. El objetivo de este trabajo fue evaluar la biomasa microbiana (BM del suelo asociada al nitrógeno (BMN; carbono (BMC y la actividad ureasa (AU en una pradera permanente del sur de Chile. Entre la primavera de 2005 y el invierno de 2006 fueron evaluados dos sistemas de pastoreo: pastoreo intenso (PI; pastoreo suave (PS y un tratamiento control (C. El diseño fue en bloques al azar con tres repeticiones. En relación a los valores promedios medidos de las variables en pre y post pastoreo; se produjo un incremento en los contenidos de CB en un 21,8 y 8,6% para PI y PS; mientras que en el control fue sólo de 1,9%. Los contenidos de NB también fueron incrementados en un 16 y 19% para PI y PS; respectivamente en comparación con el control (4%. La actividad ureasa aumentó en 13 y 27% para PI y PS; respectivamente en comparación con el control (5%. El pastoreo; produce un flujo más alto de residuos orgánicos en el suelo; lo que estimula la actividad de la biomasa microbiana y; por tanto; aumentó la AU y los contenidos de CB y NB. Esto sugiere que; en los sistemas de pastoreo; se mejora la fertilidad biológica de los suelos y la disponibilidad de nutrientes.In pasture systems, management practices can affect pasture productivity differently due to their impact on soil microorganisms and nutrient cycling. The objective of this study was to evaluate the relationship between soil microbial biomass (MB nitrogen (MBN, carbon (MBC and urease activity (UA in a permanent pasture in southern Chile. Two grazing systems were evaluated between spring 2005 and winter 2006 : heavy grazing (HG, light grazing (LG and a control treatment (C. Treatments were arranged in a randomized block design with three replications. Concerning the average values of the variables measured at

  6. Incidence of Norovirus and Other Viral Pathogens That Cause Acute Gastroenteritis (AGE) among Kaiser Permanente Member Populations in the United States, 2012-2013.

    Science.gov (United States)

    Grytdal, Scott P; DeBess, Emilio; Lee, Lore E; Blythe, David; Ryan, Patricia; Biggs, Christianne; Cameron, Miriam; Schmidt, Mark; Parashar, Umesh D; Hall, Aron J

    2016-01-01

    Noroviruses and other viral pathogens are increasingly recognized as frequent causes of acute gastroenteritis (AGE). However, few laboratory-based data are available on the incidence of AGE caused by viral pathogens in the U.S. This study examined stool specimens submitted for routine clinical diagnostics from patients enrolled in Kaiser Permanente (KP) health plans in metro Portland, OR, and the Maryland, District of Columbia, and northern Virginia geographic areas to estimate the incidence of viral enteropathogens in these populations. Over a one-year study period, participating laboratories randomly selected stools submitted for routine clinical diagnostics for inclusion in the study along with accompanying demographic and clinical data. Selected stools were tested for norovirus, rotavirus, sapovirus, and astrovirus using standardized real-time RT-PCR protocols. Each KP site provided administrative data which were used in conjunction with previously published data on healthcare utilization to extrapolate pathogen detection rates into population-based incidence rates. A total of 1,099 specimens collected during August 2012 to September 2013 were included. Mean age of patients providing stool specimens was 46 years (range: 0-98 years). Noroviruses were the most common viral pathogen identified among patients with AGE (n = 63 specimens, 6% of specimens tested). In addition, 22 (2%) of specimens were positive for rotavirus; 19 (2%) were positive for sapovirus; and 7 (1%) were positive for astrovirus. Incidence of norovirus-associated outpatient visits was 5.6 per 1,000 person-years; incidence of norovirus disease in the community was estimated to be 69.5 per 1,000 person-years. Norovirus incidence was highest among children age (outpatient incidence = 25.6 per 1,000 person-years; community incidence = 152.2 per 1,000 person-years), followed by older adults aged >65 years (outpatient incidence = 7.8 per 1,000 person-years; community incidence = 75.8 per 1,000 person

  7. La representación parlamentaria en América latina. Las comisiones permanentes y los partidos en el congreso

    Directory of Open Access Journals (Sweden)

    Luisa BÉJAR

    2009-04-01

    Full Text Available RESUMEN: El principal argumento de este escrito es que la heterogeneidad de los diseños institucionales que prima en el campo electoral en América Latina (Carroll y Shugart, 2005 también se reproduce en el parlamentario. El perfil morfológico del sistema de comisiones propio de cada Congreso y el lugar que la ley les asigna en el proceso legislativo son prueba evidente de ello. Mientras el marco normativo de algunas legislaturas no deja lugar a dudas en cuanto a la intención de delegar en los partidos las decisiones encomendadas a estos cuerpos; en otros casos, ello ocurre en menor medida. En los casos formalmente ceñidos a una lógica de partido, por otra parte, se alientan esquemas de delegación de corte muy diverso. En este escrito se revisa el acomodo institucional del sistema de comisiones de la Cámara Baja en: Argentina; Bolivia; Brasil; Colombia; Chile; México; Paraguay; República Dominicana y Uruguay. En este sentido, el estudio examina tanto la importancia concedida a su trabajo, como algunos aspectos de su morfología que afectan la estructura de incentivos que acota el desarrollo del proceso legislativo. Asimismo, se analizan los procedimientos utilizados en cada Congreso para enfrentar los problemas de acción colectiva. Por último, se presentan algunas ideas para la elaboración de una futura taxonomía sobre la relación que guardan en la región los partidos y las comisiones permanentes del Congreso.ABSTRACT: The main argument of this paper is that the heterogeneity of the institutional framework that prevails in Latin America’s electoral field (Carroll y Shugart, 2005, also reproduces itself in the parliamentary one. This is proved by the morphologic profile of each Congress’ commission system and the place that the law assigns to the system. While some legislative frameworks clearly intend to delegate to parties the decisions entrusted to this bodies; in other cases, this takes place in a less important way. In

  8. Modèle mathématique pour l'étude des équilibres physico-chimiques de permanentes.

    Science.gov (United States)

    Chiodi, F

    1989-12-01

    Résumé La plupart des permanentes du commerce sont constituées d'acide thioglycolique (éventuellement associéà l'acide thiolactique), neutralisé par l'ammoniac, elles sont additionnées de carbonate d'ammonium comme tampon. Le système peut etre traité comme la neutralisation d'un mélange d'acides thioglycolique et carbonique par l'ammoniac, et il est complètement défini par trois paramètres, trois concentrations, ou deux concentrations et le pH, ou trois paramètres analytiques indépendants. Les calculs théoriques de l'équilibre sont compliqués du fait qu'il s'agit de l'équilibre de deux diacides faibles neutralisés par une base faible. Un modèle mathématique développé exclusivement par des équations théoriques permet l'interprétation des équilibres et la réalisation des calculs fiable pour la préparation des formules remplissant certaines caractéristiques. Le modèle permet de réaliser facilement des simulations en faisant varier les concentrations, les acides (par la voie des constantes de dissociation) ou d'associer différents acids et/ou bases organiques ou minérales. Une application complémentaire du modèle est de tracer la courbe dérivée à la courbe de neutralisation et de cette façon mesurer l'effet tampon en différents points par la mesure de sa pente. Synopsis Mathematical model for the study of physico-chemical equilibria in permanent wave solutions Most waving lotions on the market are prepared with thioglycolic acid (eventually associated with thiolactic acid) neutralized with ammonium hydroxide and buffered with ammonium bicarbonate. The system can be treated as the neutralization of a mix of carbonic acid and thioglycolic acid by ammonia and it is completely defined by three parameters: three concentrations; or two concentrations and pH; or three independent analytical parameters. Theoretical calculations of the equilibrium are difficult because the equilibrium involves at least two weak acids with a weak base

  9. Construcción narrativa de los vínculos de familias sustitutas permanentes del programa aldeas infantiles SOS Bogotá

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    Carlos Arturo Castelblanco

    2012-07-01

    Full Text Available Abstract This article presents a research intervention from a systemic approach-constructivist-constructionist based on the conversational narrative - the phenomenon is to understand the narrative construction of permanent substitute families of the ONG children’s villages SOS Bogota-Colombia in relation to the senses of family identity, belonging, permanence and organizational process associated with the construction of possibilities of welfare and autonomy. Participated two foster families consisting of mother, aunt, nine children or young people, as well as juvenile companions, the psychosocial team and management of the organization. The approach is qualitative design of conversational scenarios and reflective equipment. As results is understandable experience to link families based in the relational discursive dynamics, narrated, lived and validated in multiple ways and strategies against the dilemmas that live to build family in an organizational context. It redefines the concept of family as well, seeing it now as a metaphor, generative system where they develop and strengthen the dimensions of being, allowing their emancipation. It also covers the conversational narrative as reflective gear construction itself, which accounts for the self-adaptive learning context recursive structures in language. Resumen El presente artículo expone una investigación-intervención desde un enfoque sistémico-constructivista-construccionista basado en la narrativa conversacional, cuyo objeto consistió en comprender la construcción narrativa de los vínculos de las familias sustitutas permanentes de la ONG Aldeas Infantiles SOS Bogotá-Colombia, en relación con los sentidos de identidad familiar, pertenencia, permanencia y proceso organizacional, asociados a la construcción de posibilidades de bienestar y autonomía. Participaron dos familias sustitutas, constituidas por madre, tía social y nueve niños o jóvenes, además de acompa

  10. Incidence of Norovirus and Other Viral Pathogens That Cause Acute Gastroenteritis (AGE) among Kaiser Permanente Member Populations in the United States, 2012–2013

    Science.gov (United States)

    Grytdal, Scott P.; Biggs, Christianne; Cameron, Miriam; Schmidt, Mark; Parashar, Umesh D.; Hall, Aron J.

    2016-01-01

    Noroviruses and other viral pathogens are increasingly recognized as frequent causes of acute gastroenteritis (AGE). However, few laboratory-based data are available on the incidence of AGE caused by viral pathogens in the U.S. This study examined stool specimens submitted for routine clinical diagnostics from patients enrolled in Kaiser Permanente (KP) health plans in metro Portland, OR, and the Maryland, District of Columbia, and northern Virginia geographic areas to estimate the incidence of viral enteropathogens in these populations. Over a one-year study period, participating laboratories randomly selected stools submitted for routine clinical diagnostics for inclusion in the study along with accompanying demographic and clinical data. Selected stools were tested for norovirus, rotavirus, sapovirus, and astrovirus using standardized real-time RT-PCR protocols. Each KP site provided administrative data which were used in conjunction with previously published data on healthcare utilization to extrapolate pathogen detection rates into population-based incidence rates. A total of 1,099 specimens collected during August 2012 to September 2013 were included. Mean age of patients providing stool specimens was 46 years (range: 0–98 years). Noroviruses were the most common viral pathogen identified among patients with AGE (n = 63 specimens, 6% of specimens tested). In addition, 22 (2%) of specimens were positive for rotavirus; 19 (2%) were positive for sapovirus; and 7 (1%) were positive for astrovirus. Incidence of norovirus-associated outpatient visits was 5.6 per 1,000 person-years; incidence of norovirus disease in the community was estimated to be 69.5 per 1,000 person-years. Norovirus incidence was highest among children incidence = 25.6 per 1,000 person-years; community incidence = 152.2 per 1,000 person-years), followed by older adults aged >65 years (outpatient incidence = 7.8 per 1,000 person-years; community incidence = 75.8 per 1,000 person

  11. Voces de Complementariedad: una Nueva Propuesta Para la Prevención de la Violencia en el Ámbito de la Educación Permanente

    Directory of Open Access Journals (Sweden)

    Cecilia Vicentini

    2003-01-01

    Full Text Available Se realizó una investigación de carácter cualitativo para demostrar que exis-te necesidad en este nuevo siglo de construir un nuevo pensamiento racional a través de la práctica de la complementariedad si queremos disminuir los niveles de violencia en el planeta. Hasta ahora hemos aceptado un mundo basado en polaridades y opuestos y hemos hecho la guerra porque no podemos aceptar las diferencias entre las personas. Hemos aceptado vivir en un mundo dividido donde la separación es vista como algo normal, como el resultado de la prácti-ca de viejas formas de pensamiento; esta situación es una de las causas princi-pales de la violencia hoy día, estamos tan distantes unos de otros que no pode-mos construir espacios comunes donde encontramos y estar juntos El objetivo principal del estudio fue proponer la necesidad de la complemen-tariedad a través de la construcción de puentes entre los seres humanos, entre hombres y mujeres, entre grupos en conflicto dentro de una nación y entre naciones. Nosotros, como seres humanos, necesitamos participar en la cons-trucción de nuevas realidades, necesitamos desarrollar el poder de imaginar y sonar nuevas formas de existencia en el planeta tierra. De Beauport es una experta educativa emergente que propone un modelo de inteligencias múltiples como camino de prevención de la violencia; ella plantea que hay 3 obstáculosp rincipales a la paz: la creencia de que para resolver los conflictos debemos utili-zar la fuerza, sea mental o física; el manejo inadecuado del miedo y las frustra-ciones y la práctica de un dualismo que ocasiona que la gente se vea como opuestos y en permanente confrontación. Estos tres factores forman la plataforma del presente estudio, realizado en el contexto de una sociedad muy polarizada en el aspecto político, en el cual la violencia se está convirtiendo en una situación crítica: la sociedad venezolana. El objetivo principal del estudio fue experimentar estrategias para

  12. The influence of authentic scientific research experiences on teachers' conceptions of the nature of science (NOS) and their NOS teaching practices

    Science.gov (United States)

    Moriarty, Meghan A.

    This study explored the influence of teachers' authentic scientific research experiences (ASREs) on teachers' conceptions of the nature of science (NOS) and teachers' NOS instruction. Twelve high school biology teachers participated in this study. Six of the participants had authentic scientific research experience (ASRE) and six had not participated in authentic scientific research. Data included background surveys, modified Views of the Nature of Science (VNOS) questionnaires, interviews, and teaching observations. Data was coded based on the eight NOS understandings outlined in 2013 in the Next Generation Science Standards (NGSS). Evidence from this study indicates participating in authentic scientific research as a member of a scientific community has dual benefits of enabling high school science teachers with informed understandings of the NOS and positioning them to teach with the NOS. However, these benefits do not always result from an ASRE. If the nature of the ASRE is limited, then it may limit teachers' NOS understandings and their NOS teaching practices. The results of this study suggest that participation in ASREs may be one way to improve teachers' NOS understandings and teaching practices if the experiences themselves offer a comprehensive view of the NOS. Because ASREs and other science learning experiences do not always offer such experiences, pre-service teacher education and professional development opportunities may engage science teachers in two ways: (1) becoming part of a scientific community may enable them to teach with NOS and (2) being reflective about what being a scientist means may improve teachers' NOS understandings and better position them to teach about NOS.. Keywords: nature of science, authentic scientific research experiences, Next Generation Science Standards, teaching about NOS, teaching with NOS.

  13. Los derechos humanos y los sociales, susceptibles de permanente reinvención: una mirada innovadora desde el presente en sintonía con el pasado.

    Directory of Open Access Journals (Sweden)

    María José Lacalzada-de-Mateo

    2018-05-01

    Full Text Available Es conocido que el Trabajo social defiende la autonomía de la persona y favorece la inclusión en el medio, mejorando sus oportunidades. La palabra “innovación” hoy adquiere protagonismo en la intervención, en particular, y para la estructuración de los Estados y las relaciones políticas, en general. Los Derechos Humanos y su derivación en sociales arrostran tales dificultades, tales presiones estructurales, que quienes los defienden han de mantener una actitud que parezca innovadora. Es la clave con la que se presupone credibilidad dentro del culto a lo inmediato que nos envuelve hoy. Defender los derechos de las personas es recoger un testigo humanizador que toma por referente la dignidad humana. Siempre que se ha tenido esta actitud han mejorado las relaciones en sociedad. Está en el fundamento de los Estados de Bienestar, estableciendo reglas que han mejorado el acceso al reparto de las riquezas, objetivando normas y derechos en el espacio público. Si nos situamos historiográficamente en el siglo XIX encontraremos una perspectiva que fue reformadora e innovadora en el pasado y que mantiene su fuerza revolucionaria en el presente: ajustar el ángulo de visión desde la dignidad y sentido integral de la persona humana. Discurrir así, tiene capacidad para mejorar las intervenciones y para objetivar normas para hacer viable la justicia social y con ello orientar la práctica del Trabajo Social hacia la promoción de las personas y colectivos más vulnerables de la sociedad. Llevaremos la atención sobre esta forma de discurso que recoge cierto legado humanista que encamina a construir un mundo más sostenible.

  14. Educação Permanente em SBV e SAVC: impacto no conhecimento dos profissionais de enfermagem Educación permanente en SBV y SAV: impacto en el conocimiento de los profesionales de enfermería Permanent Education in BLS and ACLS: impact on the knowledge of nursing professionals

    Directory of Open Access Journals (Sweden)

    Sandro Gonçalves de Lima

    2009-12-01

    Full Text Available FUNDAMENTO: O conhecimento teórico e as habilidades práticas das equipes de Suporte Básico de Vida (SBV e Suporte Avançado de Vida (SAV estão entre os determinantes mais importantes das taxas de sucesso em reanimação cardiopulmonar. OBJETIVO: Avaliar o impacto de um programa permanente de treinamento em SBV e SAV no conhecimento dos profissionais de enfermagem. MÉTODO: Estudo de corte transversal. A população foi composta por profissionais de enfermagem de um hospital de nível terciário. Foram realizadas avaliações antes e após o treinamento. Abordaram-se pontos críticos das diretrizes do International Liaison Committee on Resuscitation (ILCOR. RESULTADOS: Foram avaliados 213 profissionais (76 enfermeiros, 35,7%; 38 auxiliares, 17,8%; e 99 técnicos, 46,7%. As médias na avaliação pré-curso foram estatisticamente diferentes (pFUNDAMENTO: El conocimiento teórico y las habilidades prácticas de los equipos de Soporte Básico de Vida (SBV y Soporte Avanzado de Vida (SAV están entre los determinantes más importantes de los índices de éxito en reanimación cardiopulmonar. OBJETIVO: Evaluar el impacto de un programa permanente de entrenamiento en SBV y SAV en el conocimiento de los profesionales de enfermería. MÉTODO: Estudio de corte transversal. La población estaba compuesta por profesionales de enfermería de un hospital de nivel terciario. Se realizaron evaluaciones antes y después del entrenamiento. Se abordaron puntos críticos de las directrices del International Liaison Committee on Resuscitation (ILCOR. RESULTADOS: Se evaluaron 213 profesionales (76 enfermeros, 35,7%, 38 auxiliares, 17,8% y 99 técnicos, 46,7%. Los promedios en la evaluación previa al curso fueron estadísticamente diferentes (pBACKGROUND: The theoretical knowledge and practical skills of the Basic Life Support (BLS and the Advanced Life Support (ALS are among the most important determining factors of the cardiopulmonary reanimation success rates

  15. Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS

    Directory of Open Access Journals (Sweden)

    Mohamed A. Morsy

    2014-01-01

    Full Text Available Gentamicin, an aminoglycoside antibiotic, is used for the treatment of serious Gram-negative infections. However, its usefulness is limited by its nephrotoxicity. Sildenafil, a selective phosphodiesterase-5 inhibitor, was reported to prevent or decrease tissue injury. The aim of this study is to evaluate the potential protective effects of sildenafil on gentamicin-induced nephrotoxicity in rats. Male Wistar rats were injected with gentamicin (100 mg/kg/day, i.p. for 6 days with and without sildenafil. Sildenafil administration resulted in nephroprotective effect in gentamicin-intoxicated rats as it significantly decreased serum creatinine and urea, urinary albumin, and renal malondialdehyde and nitrite/nitrate levels, with a concomitant increase in renal catalase and superoxide dismutase activities compared to gentamicin-treated rats. Moreover, immunohistochemical examination revealed that sildenafil treatment markedly reduced inducible nitric oxide synthase (iNOS expression, while expression of endothelial nitric oxide synthase (eNOS was markedly enhanced. The protective effects of sildenafil were verified histopathologically. In conclusion, sildenafil protects rats against gentamicin-induced nephrotoxicity possibly, in part, through its antioxidant activity, inhibition of iNOS expression, and induction of eNOS production.

  16. Effects of cyclooxygenase inhibitor pretreatment on nitric oxide production, nNOS and iNOS expression in rat cerebellum.

    Science.gov (United States)

    Di Girolamo, G; Farina, M; Riberio, M L; Ogando, D; Aisemberg, J; de los Santos, A R; Martí, M L; Franchi, A M

    2003-07-01

    1. The therapeutic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is thought to be due mainly to its inhibition of cyclooxygenase (COX) enzymes, but there is a growing body of research that now demonstrates a variety of NSAIDs effects on cellular signal transduction pathways other than those involving prostaglandins. 2. Nitric oxide (NO) as a free radical and an agent that gives rise to highly toxic oxidants (peroxynitrile, nitric dioxide, nitron ion), becomes a cause of neuronal damage and death in some brain lesions such as Parkinson and Alzheimer disease, and Huntington's chorea. 3. In the present study, the in vivo effect of three NSAIDs (lysine clonixinate (LC), indomethacine (INDO) and meloxicam (MELO)) on NO production and nitric oxide synthase expression in rat cerebellar slices was analysed. Rats were treated with (a) saline, (b) lipopolysaccharide (LPS) (5 mg kg(-1), i.p.), (c) saline in combination with different doses of NSAIDs and (d) LPS in combination with different doses of NSAIDs and then killed 6 h after treatment. 4. NO synthesis, evaluated by Bred and Snyder technique, was increased by LPS. This augmentation was inhibited by coadministration of the three NSAIDs assayed. None of the NSAIDs tested was able to modify control NO synthesis. 5. Expression of iNOS and neural NOS (nNOS) was detected by Western blotting in control and LPS-treated rats. LC and INDO, but not MELO, were able to inhibit the expression of these enzymes. 6. Therefore, reduction of iNOS and nNOS levels in cerebellum may explain, in part, the anti-inflammatory effect of these NSAIDs and may also have importance in the prevention of NO-mediated neuronal injury.

  17. Contribution of the nos-pdt operon to virulence phenotypes in methicillin-sensitive Staphylococcus aureus.

    Directory of Open Access Journals (Sweden)

    April M Sapp

    Full Text Available Nitric oxide (NO is emerging as an important regulator of bacterial stress resistance, biofilm development, and virulence. One potential source of endogenous NO production in the pathogen Staphylococcus aureus is its NO-synthase (saNOS enzyme, encoded by the nos gene. Although a role for saNOS in oxidative stress resistance, antibiotic resistance, and virulence has been recently-described, insights into the regulation of nos expression and saNOS enzyme activity remain elusive. To this end, transcriptional analysis of the nos gene in S. aureus strain UAMS-1 was performed, which revealed that nos expression increases during low-oxygen growth and is growth-phase dependent. Furthermore, nos is co-transcribed with a downstream gene, designated pdt, which encodes a prephenate dehydratase (PDT enzyme involved in phenylalanine biosynthesis. Deletion of pdt significantly impaired the ability of UAMS-1 to grow in chemically-defined media lacking phenylalanine, confirming the function of this enzyme. Bioinformatics analysis revealed that the operon organization of nos-pdt appears to be unique to the staphylococci. As described for other S. aureus nos mutants, inactivation of nos in UAMS-1 conferred sensitivity to oxidative stress, while deletion of pdt did not affect this phenotype. The nos mutant also displayed reduced virulence in a murine sepsis infection model, and increased carotenoid pigmentation when cultured on agar plates, both previously-undescribed nos mutant phenotypes. Utilizing the fluorescent stain 4-Amino-5-Methylamino-2',7'-Difluorofluorescein (DAF-FM diacetate, decreased levels of intracellular NO/reactive nitrogen species (RNS were detected in the nos mutant on agar plates. These results reinforce the important role of saNOS in S. aureus physiology and virulence, and have identified an in vitro growth condition under which saNOS activity appears to be upregulated. However, the significance of the operon organization of nos-pdt and

  18. cuidado nos serviços de saúde mental

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    Cláudia Mara de Melo Tavares

    2006-01-01

    Full Text Available Estudio exploratório, cuyo objetivo fue analizar la necesidad de la educación permanente del equipo de enfermera para cuidar en los servicios de la salud mental. Fueron estudiadas treinta siete profesionales de enfermería mental. Como resultados, se verificó que él equipe de la enfermería demanda calificación de vasto espectro. Se concluye que la educación permanente del equipo del oficio de enfermera de la salud mental exige más allá de programas educativos establecidos en la definición de las capacidades específicas, de procesos educativos crítico que tienen como objetivo el desarrollo del conocimiento del carácter a interdisciplinar.

  19. A utilização de novos sistemas construtivos para a redução no uso de insumos nos canteiros de obras: Light Steel Framing

    Directory of Open Access Journals (Sweden)

    Hylton Olivieri

    Full Text Available Resumo A utilização de novos sistemas construtivos pode representar reduções consideráveis no uso de insumos e operações nos canteiros de obras, tais como menor consumo de mão de obra na produção, redução na geração de resíduos, otimização da logística local, menor consumo de água e redução dos prazos de obra. Nesse contexto, o sistema Light Steel Framing (LSF apresenta-se como um processo de grande potencial quando utilizado como um sistema construtivo para a produção de fachadas, em substituição ao sistema tradicional, composto de alvenaria de vedação e revestimento externo aderido, principalmente em edifícios com múltiplos pavimentos. O objetivo deste trabalho é comparar o LSF e o sistema tradicional de produção de fachadas, considerando-se quantitativamente a utilização de mão de obra, geração de resíduos, consumo de água e prazos de obra, por meio da análise de quatro estudos de caso em dois países (Brasil e Alemanha, que consideram empreendimentos para fins de moradia permanente ou temporária. As principais contribuições deste estudo estão relacionadas aos índices de consumo de mão de obra do LSF, apurados a partir dos estudos de caso, além de suas potenciais vantagens em comparação ao sistema tradicional.

  20. Participação nos Lucros ou Resultados

    Directory of Open Access Journals (Sweden)

    Luiz Felipe Ferreira

    2007-03-01

    Full Text Available A participação nos lucros ou resultados é uma forma de remuneração variável, pela qual não há incidência de encargos sociais, além de incentivar o aumento da produtividade, podendo assim ser utilizada pelas empresas como estratégia, para enfrentarem os desafios dinâmicos e competitivos em que atuam. Esta pesquisa caracteriza-se como sendo exploratória, com abordagem qualitativa e tem como objetivo conceituar e explanar as formas pela quais são praticadas a participação nos lucros ou resultados em empresas do setor alimentício em Santa Catarina, que foram escolhidas por meio do critério de acessibilidade e disponibilidade. Dos dados coletados, pode-se verificar que as empresas: COC Alimentos, Moinho Catarinense e Pepsico do Brasil utilizam a participação nos resultados e a Perdigão utiliza a participação mista. A Moinho Catarinense distribui para todos os empregados um salário nominal, como a CDC Alimentos, exceto para os gerentes. A Perdigão beneficia todos os empregados, sendo que 60% da distribuição é pelo lucro líquido e 40% por indicadores de desempenho. A Pepsico do Brasil distribui aos empregados operacionais 50% de um salário nominal e para os empregados da administração central um salário nominal, atrelado ao cumprimento de metas, especificadas no programa de participação nos lucros ou resultados.

  1. Tratamento de dejetos suínos com biorreator UASB

    Directory of Open Access Journals (Sweden)

    Pablo Costa da Silva

    2014-05-01

    Full Text Available Esse trabalho tem por objetivo analisar a importância do biodigestor UASB no tratamento de dejetos suínos. A suinocultura possui papel importante quanto ao desenvolvimento econômico do Brasil. No entanto, o aumento de produção vem causando problemas ambientais graves, por conta do grande volume de resíduos sólidos gerados pela atividade. O desenvolvimento de métodos de tratamento de dejetos que agreguem valor à produção e respeitem as leis ambientais é um dos grandes desafios do setor. A biodigestão anaeróbia é um dos métodos mais eficazes para o tratamento de dejetos de suinoculturas. Este método de digestão, denominado UASB, tem como característica principal a produção de biogás e de biofertilizante, produto rico em nutrientes, e livre de patógenos. O método oferece vantagens como a promoção do bem estar animal, o aumento da fertilidade do solo, a diminuição da poluição e da emissão de gases geradores do efeito estufa e a melhoria da qualidade de vida, nos centros produtores de suínos, além de minimizar problemas relacionados ao déficit de energia elétrica. Portanto, a utilização de biodigestores UASB para o tratamento de dejetos de suínos é uma opção interessante, que deve ser avaliada com seriedade.

  2. Pragmatismo e os pragmáticos nos estudos organizacionais

    Directory of Open Access Journals (Sweden)

    Francis Kanashiro Meneghetti

    Full Text Available O objetivo central deste ensaio teórico é avaliar as contribuições do pragmatismo nos Estudos Organizacionais e, os específicos, avaliar se as contribuições teóricas de Charles Peirce e John Dewey possibilitam afirmar o pragmatismo como senso comum, ciência ou teoria do conhecimento; analisar as contribuições - possibilidadese limites - do pragmatismo como conhecimento científico; compreender os percursos do pragmatismo nos Estudos Organizacionais. Chaga-se a conclusão de que ser pragmático é diferente de conceber estudos articulados no campo epistemológico do pragmatismo. O sujeito pragmático vê na sua utilidade e na necessidade deação, o ponto de tensão que coloca em dúvida a veracidade dos pressupostos do pragmatismo como ciência. O que ocorre nos Estudos Organizacionais éa conversão do pragmatismo como conhecimento científico emsubordinação irracional à utilidade e à ação prática, sobretudo, no campo da economia, da política, da ciência, da cultura, da educação, e assim por diante.

  3. Penser Système : Découvrir nos modèles d'organisation

    NARCIS (Netherlands)

    Bryan, B.; Goodman, M.; Schaveling, J.

    2011-01-01

    Pourquoi le travail s’accumule-t-il sur nos bureaux alors que nous travaillons de plus en plus? Parfois « nos solutions » aggravent nos problèmes. Comment pouvons-nous éviter ces paradoxes ? Penser système donne de nouvelles perspectives dans des situations complexes. Cela vous permettra de

  4. Control permanente de la gestión sanitaria por monitoreo de costos mediante acontecimientos indicadores Ongoing health management control by cost monitoring through tracer indicators

    Directory of Open Access Journals (Sweden)

    Horacio Villanueva

    2001-12-01

    Full Text Available Objetivos. Determinar el costo operacional de un servicio quirúrgico, comparar los resultados con estándares y determinar la incidencia de costos. Obtener una metodología eficaz para este fin, extrapolable a todo tipo de servicio asistencial y de fácil instrumentación en una herramienta informática convencional (base de datos de alta difusión y bajo costo que pueda usarse en el control permanente de la gestión. Métodos. El estudio se realizó durante 1999 en el Servicio de Ortopedia y Traumatología del Hospital Estatal "Domingo Funes", Córdoba, Argentina. De los 817 pacientes sometidos a procedimientos diagnósticos o terapéuticos en ese servicio a lo largo del año, se seleccionaron los 154 que necesitaron internación y maniobras quirúrgicas o instrumentales. Se utilizó el método de acontecimientos indicadores descrito por Kessner. Dichos acontecimientos, clasificados en función de su complejidad (alta, mediana, escasa o nula, fueron seleccionados y definidos por consenso de expertos: especialistas médicos y economistas. Se valoraron los costos directos e indirectos para estudiar su peso en el costo total, en cuya estimación se utilizaron nueve variables que se aplicaron a los diferentes acontecimientos indicadores. Resultados. El mayor peso del costo total, tanto estándar como real, recayó en ambos casos sobre la variable "día cama". De la variable "día cama" en el total de acontecimientos indicadores, el 51,2% correspondió a la internación social (costo indirecto y el 48,8% a la internación terapéutica (costo directo. Su diferencia con respecto al costo estándar fue un aumento del orden del 117%. Los costos indirectos (internación social e insumos terapéuticos absorbieron casi la mitad del costo real total. El costo real de todos los acontecimientos investigados, sin incluir los costos indirectos, solo superó al costo estándar en un 6,4%. Incluyendo los costos indirectos (internación social e insumos terap

  5. The Permanent Disposal of Highly Radioactive Wastes by Incorporation into Glass; Elimination Permanente de Dechets Hautement Radioactifs par Incorporation dans le Verre; 041e 041a 041e 041d 0427 0414 ; La Evacuacion Permanente de Desechos de Elevada Radiactividad Incorporandolos en Vidrio

    Energy Technology Data Exchange (ETDEWEB)

    Watson, L. C.; Aikin, A. M.; Bancroft, A. I. [Atomic Energy of Canada Ltd. (Canada)

    1960-07-01

    Development of a process for the incorporation of the high-level wastes from chemical processing operations into glass for permanent disposal has continued at Chalk River. The process has been demonstrated by making glass containing up to 50 curies of five- to six-year old mixed fission products per kg. The operation was batch wise, on a scale of four kg per batch. These operations showed that the fission products could be incorporated into glass safely and conveniently. Consideration of the many problems involved in the permanent storage or disposal of the highly radioactive glass has resulted in the conclusion that it should be buried in the ground or stored in artificial vaults. In such conditions, the disposal may always be-subjected to further control if required. If disposal is made directly to the ground, the principal method by which fission products can be released to the environment is by leaching from the glass into water. It is therefore considered important to know the rate at which fission products will be dispersed by this mechanism. Considerable data on leaching by water have been obtained in the laboratory. It has been found that the rates of release depend on the composition of the glass. For all the compositions tested the measurements showed that the rate of leaching of fission products from the glass decreased with time. After several months in water the rate of release of several compositions was about 10{sup -4} per cent per year from a two kg hemisphere of glass. The data obtained have been used to estimate the release of fission products from glass containing the large quantities of fission products which will accumulate from operation of power reactors. (author) [French] On poursuit a Chalk River les travaux de mise au point d'un procede permettant d'incorporer dans le verre, pour elimination permanente, des dechets hautement radioactifs provenant d'operations de traitement chimique! Aux fins de demonstration du procede, on a fabrique du

  6. Preceptoria de território, novas práticas e saberes na estratégia de educação permanente em saúde da família: o estudo do caso de Sobral, CE Preceptorship of territory, new practices and knowledge in the strategy of continuing education in family health strategy: the case study of Sobral, Ceara, Brazil

    Directory of Open Access Journals (Sweden)

    Rosani Pagani

    2012-05-01

    Full Text Available O presente trabalho pretende apresentar um novo ator no Sistema Único de Saúde - o preceptor de território - bem como discutir sua atuação. Com a implantação da Estratégia Saúde da Família, bastante se tem discutido sobre o desafio de formar profissionais para atuarem neste modelo através de educação permanente em saúde. Nesse processo, o município de Sobral, CE, criou em 1999 a residência multiprofissional e a preceptoria de território; em 2001, a Escola de Formação em Saúde da Família Visconde de Sabóia. Este estudo teve como objetivos analisar a implantação e a atuação da preceptoria de território, descrevendo o processo de trabalho dos preceptores e identificando suas competências; além disso, descreveu-se o processo de educação permanente desenvolvido na Estratégia de Saúde da Família em Sobral. Utilizou-se uma abordagem qualitativa do tipo estudo de caso, com os seguintes instrumentos: entrevistas, questionários e grupo focal. Para a organização os dados foram analisados através da técnica do Discurso do Sujeito Coletivo (DSC. Entre os achados do estudo, identifica-se o preceptor de território como um profissional que atua diretamente com os residentes nos territórios das equipes da estratégia de saúde da família, destacando-se por suas amplas competências. Entre estas, podem ser mencionados conhecimentos conceituais nos campos da saúde coletiva e das relações humanas, bem como conhecimento e desenvoltura na utilização de métodos de ensino (problematização, educação permanente em saúde e educação popular. Deve também ser capaz de desenvolver relações harmônicas e de participação. O debate vem auxiliando o preceptor de território de Sobral a estabelecer seu papel e consolidar sua função de educador na construção do SUS.This paper aims to present a new actor in the Health's Unique System of Brazil (SUS, the preceptor of territory, and discuss his performance. The

  7. The effect of high protein diet and exercise on irisin, eNOS, and iNOS expressions in kidney.

    Science.gov (United States)

    Tastekin, Ebru; Palabiyik, Orkide; Ulucam, Enis; Uzgur, Selda; Karaca, Aziz; Vardar, Selma Arzu; Yilmaz, Ali; Aydogdu, Nurettin

    2016-08-01

    Long-term effects of high protein diets (HPDs) on kidneys are still not sufficiently studied. Irisin which increases oxygen consumption and thermogenesis in white fat cells was shown in skeletal muscles and many tissues. Nitric oxide synthases (NOS) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. We aimed to investigate the effects of HPD, irisin and NO expression in kidney and relation of them with exercise and among themselves. Animals were grouped as control, exercise, HPD and exercise combined with HPD (exercise-HPD). Rats were kept on a HPD for 5 weeks and an exercise program was given them as 5 exercise and 2 rest days per week exercising on a treadmill with increasing speed and angle. In our study, while HPD group had similar total antioxidant capacity (TAC) levels with control group, exercise and exercise-HPD groups had lower levels (p highly selective and quite clear in this study. Effects of exercise and HPD on kidney should be evaluated with different exercise protocols and contents of the diet. İrisin, eNOS, and iNOS staining localizations should be supported with various research studies.

  8. La difusión e interpretación del Patrimonio cultural e histórico-educativo como tema de estudio en el Centro de Formación Permanente de la Universidad de Sevilla

    Directory of Open Access Journals (Sweden)

    Pablo Álvarez Domínguez

    2010-06-01

    Full Text Available (ES Recoge este texto el resultado de una experiencia educativa organizada por el Museo Pedagógico Andaluz y desarrollada el pasado mes de mayo de 2010 en el Centro de Formación Permanente de la Universidad de Sevilla, con la finalidad de propiciar una reflexión teórico-práctica ligada a las nuevas posibilidades didácticas y de difusión del patrimonio cultural e histórico-educativo que se pueden desplegar en el ámbito museístico, con el fin de facilitar su estudio, comprensión y valoración.

  9. La Diputación Permanente en la Constitución de Cádiz o el intento frustrado de crear un órgano con funciones de garantía constitucional

    Directory of Open Access Journals (Sweden)

    Ángel Luis Alonso de Antonio

    2012-01-01

    Full Text Available La Diputación Permanente de la Constitución de 1812 es el órgano de continuidad parlamentaria para mantener la representación de la voluntad popular en los períodos en los que las Cortes no estuvieran trabajando en plenitud. Significó también un intento frustrado de establecer un mecanismo eficaz para garantizar el cumplimiento del propio texto constitucional y por tanto su defensa ante las violaciones por parte de otros órganos del Estado. The Permanent Delegation of the Constitution of 1812 is the parliamentary body to maintain continuity of the representation of popular will in the periods in which the courts were not working fully. It also meant an unsuccessful attempt to establish an effective mechanism to ensure compliance with the constitutional text itself and therefore its defense against violations by other state bodies.

  10. Métodos para determinação de parâmetros de máquinas síncronas de ímãs permanentes

    OpenAIRE

    Guilherme Homrich

    2016-01-01

    A teoria de duplo eixo é geralmente utilizada para modelar e caracterizar máquinas síncronas de polos salientes. O conhecimento das indutâncias de eixo direto e eixo em quadratura são fundamentais para o desenvolvimento destes modelos e para o projeto de controladores destas máquinas. No entanto, métodos tradicionais para determinação destas indutâncias através de ensaios tornam-se impraticáveis em máquinas síncronas de ímãs permanentes pela impossibilidade de controlar a corrente de campo. R...

  11. Anomalías dentomaxilofaciales en dientes permanentes y su relación con traumas en la primera infancia Dental-maxillary-facial anomalies in permanent teeth and their relation to traumas in early childhood

    Directory of Open Access Journals (Sweden)

    Arlene Liset Corrales León

    2009-03-01

    Full Text Available Se realizó un estudio descriptivo, longitudinal y retrospectivo que incluyó niños de 7 a 14 años de edad, pertenecientes al área de salud de la "Clínica Estomatológica Docente Guama" del municipio Pinar del Río, en el período comprendido entre febrero del 2003 a marzo de 2005, con el objetivo de determinar la presencia de anomalías dentomaxilofaciales en dentición permanente y su relación con traumas en la primera infancia. El universo de estudio estuvo constituido por 250 niños, y de ellos, se seleccionó una muestra de 60 niños y se les confeccionó una planilla recolectora de datos para la investigación. Los resultados obtenidos fueron procesados estadísticamente mediante el sistema automatizado STATISTIC y la prueba de CHI CUADRADO, en su aplicación de bondad de ajuste, y el paquete SPSS, para la prueba de comparación de proporciones. En todos los casos se prefija un nivel de significación de 0,05. Entre los resultados globales más significativos encontramos que fueron los traumas ocurridos en las edades de 5-6 años los que más anomalías dentomaxilofaciales causaron en la dentición permanente. Resultó el sexo masculino el más afectado por estas alteraciones, fueron los traumas recibidos directamente sobre los dientes, los mayores causantes de anomalías en la dentición permanente. Resultaron las hipoplasias del esmalte, como otras anomalías no ortodóncicas las más frecuentes; se comprobó que el sexo femenino tuvo mayor implicación psicosocial por estas alteraciones y se divulgaron a estomatólogos, padres y maestros orientaciones sobre la relación entre los traumas en la primera infancia y las anomalías dentomaxilofaciales en la dentición permanente.A descriptive, longitudinal and retrospective research was carried out including children from 7 to 14 years old belonging to the health area of "Guama" Dental University Clinic in Pinar del Rio Municipality, from February 2003 to March 2005 aimed at determining

  12. A influência da perda bilateral do primeiro molar inferior permanente na morfologia dentofacial: um estudo cefalométrico The influence of bilateral lower first permanent molar loss on dentofacial morfology: a cephalometric study

    Directory of Open Access Journals (Sweden)

    David Normando

    2010-12-01

    Full Text Available OBJETIVO: avaliar as alterações cefalométricas em pacientes com perda bilateral do primeiro molar inferior permanente. MÉTODOS: foram analisadas 68 telerradiografias laterais de pacientes de consultórios particulares. A amostra foi dividida em dois grupos pareados quanto ao sexo e idade - 34 indivíduos sem perdas (grupo controle e 34 com perda bilateral do primeiro molar inferior permanente (grupo com perda. Foram excluídos da amostra pacientes que haviam perdido outros dentes que não o primeiro molar inferior, casos de agenesia e pacientes com menos de 16 anos de idade. Buscou-se avaliar somente indivíduos que tivessem relatado a perda há pelo menos 5 anos. RESULTADOS: demonstraram que a perda bilateral do primeiro molar inferior permanente leva ao suave fechamento do ângulo GnSN (P=0,05, um giro anti-horário do plano oclusal (P=0,0001, uma suave diminuição da altura facial anteroinferior (P=0,05, uma acentuada inclinação lingual (P=0,04 e retrusão dos incisivos inferiores (P=0,03. Por outro lado, a perda bilateral do primeiro molar inferior permanente não foi capaz de influenciar a relação maxilomandibular no sentido anteroposterior (P=0,21, a quantidade de mento (P=0,45, a inclinação dos incisivos superiores (P=0,12 e a posição anteroposterior dos incisivos superiores (P=0,46. CONCLUSÃO: a perda bilateral dos primeiros molares inferiores é capaz de produzir alterações marcantes no posicionamento dos incisivos inferiores e no plano oclusal, além de uma suave redução vertical da faceOBJECTIVE: To evaluate cephalometric changes in patients after bilateral loss of lower first permanent molar teeth. METHODS: Sixty-eight lateral radiographs of patients from private practices were analyzed. The sample was divided into two groups matched for age and gender: 34 individuals without loss (control group and 34 presenting with bilateral loss of lower first permanent molar teeth (loss group. Patients who had lost teeth other

  13. Implantação das mesas nacionais de negociação permanente do Sistema Único de Saúde em secretarias estaduais e municipais de saúde

    Directory of Open Access Journals (Sweden)

    Carinne Magnago

    Full Text Available Resumo O objetivo deste artigo é avaliar a implantação da mesa de negociação permanente e identificar os entraves e os avanços decorridos dos processos de negociação no âmbito dos estados e dos municípios brasileiros. O método usado foi estudo descritivo e exploratório, de abrangência nacional. A coleta de dados se deu em 2012 e 2013, por meio de survey com 519 gestores de saúde e grupos focais com 49 gestores e 11 integrantes da Mesa Nacional de Negociação Permanente. Dados foram analisados por estatística descritiva e por análise de conteúdo. Verificou-se existência de 132 mesas de negociação, das quais apenas 87 estão em funcionamento. Os principais motivos para não implantação das mesas são a falta de assessoria técnica e a utilização de outras ferramentas para negociação do trabalho. As principais mudanças nas relações de trabalho em decorrência da atuação das mesas de negociação foram a realização de concursos e de processos seletivos públicos, políticas de desprecarização do trabalho e a implantação de planos de cargos, carreiras e salários. Conclui-se que apesar da potencialidade das mesas como dispositivos de negociação, sua implantação e seu pleno funcionamento esbarram em grandes desafios.

  14. Política de formação e educação permanente em saúde no brasil: bases legais e referências teóricas

    Directory of Open Access Journals (Sweden)

    Renata Lúcia Gigante

    Full Text Available Resumo Este artigo teve como objetivo discutir as inter-relações dos relatórios das Conferências Nacionais de Saúde com as propostas apresentadas em documentos oficiais do Sistema Único de Saúde referentes à formação e desenvolvimento de recursos humanos, buscando relacioná-los à incorporação de novos referenciais pedagógicos pautados pelas metodologias ativas de ensino-aprendizagem. O estudo aqui apresentado foi do tipo exploratório, referente à pesquisa na literatura das áreas de saúde e educação, no período de 1941 – realização da 1a Conferência Nacional de Saúde – até 2007, quando foi publicada a portaria n. 1.996 GM/MS. Essa portaria definiu novas diretrizes e estratégias para a implementação da Política Nacional de Educação Permanente em Saúde, com o objetivo de evidenciar a importância da formação de recursos humanos para a consolidação do Sistema Único de Saúde. Verificou-se que há correlação entre as reivindicações que emergem de necessidades sociais identificadas na construção do Sistema Único de Saúde e as propostas inscritas nas legislações pertinentes. Destaca-se que o sucesso de projetos de educação permanente depende de profunda imbricação entre processos educativos e de intervenção institucional, que contemplem a complexidade dos modos de fazer saúde.

  15. Historia poblacional, orígenes africanos y microevolución de los actuales afro-colombianos inferidos desde caracteres epigenéticos en la dentición decidua y permanente

    Directory of Open Access Journals (Sweden)

    Delgado Burbano, Miguel E.

    2006-01-01

    Full Text Available Setenta y cinco rasgos coronales no-métricos en la dentición permanente y decidua fueron registrados en 178 modelos dentales de individuos afro-colombianos pertenecientes a la comunidad de Guapi. Se recolectaron datos comparativos de 33 grupos africanos, otro grupo afro-estadounidense en la dentición permanente, en 4 grupos afro-americanos y otros 12 grupos de diferente ascendencia étnica, en la dentición decidua. Un análisis multivariado de componentes principales basado en frecuencias dentales, mostró que los afro-colombianos poseen gran afinidad genética con el Africa Sub-Sahariana, específicamente con grupos del Occidente, del Oriente y del Sur-Oriente africano. Este mismo análisis detectó una marcada divergencia dental con las poblaciones Norafricanas. Los resultados de esta investigación concuerdan con recientes estudios genéticos, basados en marcadores de ADNmt. A pesar que la dentición es evolutivamente conservativa y estable en una escala diacrónica corta, se concluyó que en 400 años de microevolución de los africanos en Colombia, su pool genético original se ha modificado levemente, debido a la influencia de presiones selectivas y flujo génico interétnico, con nativos americanos y grupos de origen caucásico. Se sugiere que los grupos afro-descendientes del Norte, Centro y Sur de América poseen historias poblacionales y evolutivas distintas, debido tanto a procesos de diferenciación fenotípica regional y local como a orígenes geográficos y étnicos diferentes.

  16. Simulación del Comportamiento Dinámico de un Pequeño Aerogenerador de Imán Permanente Sin Multiplicador en operación autónoma haciendo uso del MatLab

    Directory of Open Access Journals (Sweden)

    Osley López González

    2011-10-01

    Full Text Available En este trabajo los autores hacen uso del software MATLAB SIMULINK versión 7.7.0.471 R2008b para el análisis del comportamiento de un sistema generación eólico de 2 kW autónomo sin multiplicador con generador de imanes permanentes y batería de Plomo-ácido. Se utilizan para ello los modelos de los generadores de imanes permanentes, batería, convertidores así como otros elementos del sistema eléctrico existente en el toolbox SimPowerSystems de este software y se obtiene y discute el comportamiento dinámico de las variables del conjuntoturbina-generador, las variables del bus de directa, así como también las variables de la carga, ante diferentes condiciones de trabajo del sistema. Los resultados basados en simulaciones muestran el correcto funcionamiento de todas las variables de control que regulan el sistema generador eólico-elemento almacenador-carga eléctrica consumida, cuando se somete a perturbaciones típicas como lo son la variación en racha del viento y variación de la carga repentina. The utilization of the popular software MATLAB SIMULINK 7.7.0.471 in order to analyze a 2kW Direct driven Permanent Magnet generator for wind turbine in autonomous operation, including battery of Lead-acid is exposed by the authors. The existent models of the SimPowerSystems MATLAB toolbox are used in order to obtain and discuss the dynamic behavior of the principal variables under different conditions of work of the system.

  17. Reporting on a Talk I Gave Some Months Ago, the Headline in "La Opinion," Los Angeles' Premier Spanish Language Newspaper, Declared the City's School System "en crisis permanente." No One Wrote in to Disagree. The Claremont Letter. Volume 3, Issue 1

    Science.gov (United States)

    Kerchner, Charles T.

    2008-01-01

    Reporting on a talk the author gave some months ago, the headline in "La Opinion," Los Angeles' premier Spanish language newspaper, declared the city's school system "en crisis permanente." No one wrote in to disagree. Indeed, at the end of "Learning from L.A.: Institutional Change in American Public Education" (Harvard Education Press) the author…

  18. Percepção da educação permanente, continuada e em serviço para enfermeiros de um hospital de ensino La percepción de la educación permanente, continuada y en servicio para el enfermero del hospital de enseñanza The perception of permanent, continuous, in service education for nurses in a school hospital

    Directory of Open Access Journals (Sweden)

    Amarílis Schiavon Paschoal

    2007-09-01

    Full Text Available Este estudo tem como objetivo discutir a concepção de educação permanente, continuada e em serviço junto a enfermeiros de um hospital de ensino. É uma pesquisa de natureza qualitativa, na qual a coleta dos dados foi realizada pela técnica do grupo focal, durante seis sessões gravadas em áudio e vídeo. Participaram deste estudo nove enfermeiros de um hospital de ensino. Para analisar os dados, utilizou-se a técnica do discurso do sujeito coletivo, que consiste na organização e tabulação de dados qualitativos de natureza verbal obtidos por meio de depoimentos, da qual resultou um único discurso. A pesquisa demonstrou que os enfermeiros diferenciaram os termos educação permanente, continuada e em serviço, construindo conceitos próprios, ressaltando a importância da diferenciação para definir o tipo de ação a ser tomada diante da necessidade educativa apresentada.Este estudio tiene como objetivo la discusión de la concepción de los términos de la educación permanente, continuada y en servicio con enfermeros del hospital de enseñanza. Es una investigación de naturaleza cualitativa, en que fueron recogidos los datos a través de la técnica del grupo focal, durante seis sesiones grabadas en audio y video. Participaron de este estudio nueve enfermeros de un hospital de enseñanza. Para analizar los datos fue utilizada la técnica del discurso del sujeto colectivo, que consiste en la organización y tabulación de datos cualitativos de naturaleza verbal obtenidos por medio de deposiciones, que resultó de un único discurso. La investigación demostró que los enfermeros diferenciaron los términos educación permanente, continuada y en servicio, construyendo conceptos propios, resaltando la importancia de la diferenciación para definir el tipo de acción a ser tomada delante de la necesidad educativa representada.This study is aimed at discussing the conception of permanent, continuous, in service education among nurses

  19. Expression of Beta-catenin, COX-2 and iNOS in Colorectal Cancer: Relevance of COX-2 and iNOS Inhibitors for Treatment in Malaysia

    Directory of Open Access Journals (Sweden)

    Seok Kwan Hong

    2004-01-01

    Conclusions: The accumulation of β-catenin does not seem to be sufficient to activate pathways that lead to increased COX-2 and iNOS expression. A high proportion of colorectal cancers were found to express COX-2 and a significant number produced iNOS, suggesting that their inhibitors may be potentially useful as chemotherapeutic agents in the management of colorectal cancer.

  20. Using a Professional Development Program for Enhancing Chilean Biology Teachers' Understanding of Nature of Science (NOS) and Their Perceptions about Using History of Science to Teach NOS

    Science.gov (United States)

    Pavez, José M.; Vergara, Claudia A.; Santibañez, David; Cofré, Hernán

    2016-01-01

    A number of authors have recognized the importance of understanding the nature of science (NOS) for scientific literacy. Different instructional strategies such as decontextualized, hands-on inquiry, and history of science (HOS) activities have been proposed for teaching NOS. This article seeks to understand the contribution of HOS in enhancing…

  1. Beer elicits vasculoprotective effects through Akt/eNOS activation.

    Science.gov (United States)

    Vilahur, Gemma; Casani, Laura; Mendieta, Guiomar; Lamuela-Raventos, Rosa M; Estruch, Ramon; Badimon, Lina

    2014-12-01

    There is controversy regarding the effect of alcohol beverage intake in vascular vasodilatory function in peripheral arteries. The effects of beer intake in coronary vasodilation remain unknown. We investigated whether regular beer intake (alcohol and alcohol-free) protects against hypercholesterolaemia-induced coronary endothelial dysfunction and the mechanisms behind this effect. Pigs were fed 10 days: (i) a Western-type hypercholesterolaemic diet (WD); (ii) WD+low-dose beer (12·5 g alcohol/day); (iii) WD+moderate-dose beer (25 g alcohol/day); or (iv) WD+moderate-dose alcohol-free-beer (0·0 g alcohol/day). Coronary responses to endothelium-dependent vasoactive drugs (acetylcholine: receptor mediated; calcium ionophore-A23189: nonreceptor mediated), endothelium-independent vasoactive drug (SNP) and L-NMMA (NOS-antagonist) were evaluated in the LAD coronary artery by flow Doppler. Coronary Akt/eNOS activation, MCP-1 expression, oxidative DNA damage and superoxide production were assessed. Lipid profile, lipoproteins resistance to oxidation and urinary isoxanthohumol concentration were evaluated. Alcoholic and nonalcoholic beer intake prevented WD-induced impairment of receptor- and non-receptor-operated endothelial-dependent coronary vasodilation. All animals displayed a similar vasodilatory response to SNP and L-NMMA blunted all endothelial-dependent vasorelaxation responses. Haemodynamic parameters remained unchanged. Coronary arteries showed lower DNA damage and increased Akt/eNOS axis activation in beer-fed animals. Animals taking beer showed HDL with higher antioxidant capacity, higher LDL resistance to oxidation and increased isoxanthohumol levels. Weight, lipids levels, liver enzymes and MCP-1 expression were not affected by beer intake. Non-alcoholic-related beer components protect against hyperlipemia-induced coronary endothelial dysfunction by counteracting vascular oxidative damage and preserving the Akt/eNOS pathway. Light-to-moderate beer

  2. A Fast Response Capability within NOAA/NOS/CO-OPS

    Science.gov (United States)

    2007-01-01

    A Fast Response Capability within NOAA/NOS/CO-OPS P. B. Burke NOAA/National Ocean Service/CO-OPS 1305 East-West Hwy. Silver Spring, MD 20910...USA pat.burke@noaa.gov T. Graff NOAA/National Ocean Service/CO-OPS 1305 East-West Hwy. Silver Spring, MD 20910 USA tammy.graff@noaa.gov... flotation hull, an instrumentation tower mounted atop the hull and a current meter mount with a mooring attachment. The triangular tower housed two

  3. O trabalho de vigilância nos centros comerciais

    OpenAIRE

    Gadea,Charles; Cruz,Sofia Alexandra

    2013-01-01

    Este artigo visa escrutinar em termos sociológicos a atividade profissional dos vigilantes nos centros comerciais, analisando o tipo de competências profissionais exigidas, a configuração da hierarquia profissional da vigilância e sua articulação com a comunicação cotidiana entre os vigilantes e, por fim, os desafios e dilemas subjacentes ao ato de vigiar. A pesquisa baseia-se metodologicamente em dados obtidos a partir de entrevistas semidiretivas a vigilantes e observação direta dos seus es...

  4. Medo de que? : uma historia do horror nos filmes brasileiros

    OpenAIRE

    Laura Loguercio Canepa

    2008-01-01

    Resumo: Neste trabalho, examinam-se as manifestações do gênero horror nos longas-metragens sonoros brasileiros realizados entre 1937 e 2007, elaborando-se um panorama histórico desses filmes, desde os primeiros registros cinematográficos deste gênero de ficção no cinema nacional até os mais recentes, e propondo-se um modelo descritivo para as configurações do horror ficcional no cinema brasileiro. Para isso, partiu-se dos estudos de gêneros cinematográficos, de história do cinema mundial e de...

  5. Non-ergodicity of Nosé–Hoover dynamics

    International Nuclear Information System (INIS)

    Legoll, Frédéric; Luskin, Mitchell; Moeckel, Richard

    2009-01-01

    The Nosé–Hoover dynamics is a deterministic method that is commonly used to sample the canonical Gibbs measure. This dynamics extends the physical Hamiltonian dynamics by the addition of a 'thermostat' variable, which is coupled nonlinearly with the physical variables. The accuracy of the method depends on the dynamics being ergodic. Numerical experiments have been published earlier that are consistent with non-ergodicity of the dynamics for some model problems. The authors recently proved the non-ergodicity of the Nosé–Hoover dynamics for the one-dimensional harmonic oscillator. In this paper, this result is extended to non-harmonic one-dimensional systems. We also show that, for some multidimensional systems, the averaged dynamics for the limit of infinite thermostat 'mass' has many invariants, thus giving theoretical support for either non-ergodicity or slow ergodization. Numerical experiments for a two-dimensional central force problem and the one-dimensional pendulum problem give evidence for non-ergodicity

  6. Ergodicity of the Stochastic Nosé-Hoover Heat Bath

    Science.gov (United States)

    Wei Chung Lo,; Baowen Li,

    2010-07-01

    We numerically study the ergodicity of the stochastic Nosé-Hoover heat bath whose formalism is based on the Markovian approximation for the Nosé-Hoover equation [J. Phys. Soc. Jpn. 77 (2008) 103001]. The approximation leads to a Langevin-like equation driven by a fluctuating dissipative force and multiplicative Gaussian white noise. The steady state solution of the associated Fokker-Planck equation is the canonical distribution. We investigate the dynamics of this method for the case of (i) free particle, (ii) nonlinear oscillators and (iii) lattice chains. We derive the Fokker-Planck equation for the free particle and present approximate analytical solution for the stationary distribution in the context of the Markovian approximation. Numerical simulation results for nonlinear oscillators show that this method results in a Gaussian distribution for the particles velocity. We also employ the method as heat baths to study nonequilibrium heat flow in one-dimensional Fermi-Pasta-Ulam (FPU-β) and Frenkel-Kontorova (FK) lattices. The establishment of well-defined temperature profiles are observed only when the lattice size is large. Our results provide numerical justification for such Markovian approximation for classical single- and many-body systems.

  7. A sociologia funcionalista nos estudos organizacionais: foco em Durkheim

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    Augusto Cabral

    Full Text Available O tema que estrutura este ensaio é o da sociologia funcionalista, particularmente em termos de sua influência nos estudos organizacionais. O seu foco de análise é duplo. Em um primeiro momento, as obras de Durkheim. Em um segundo momento, o impacto e a supremacia dos enfoques funcionalistas nos estudos organizacionais. Embora seus segmentos estejam inter-relacionados, ele é composto de quatro partes. Na primeira, é feita uma análise histórica da emergência e sistematização das ciências sociais, de modo a traçar sua evolução até o surgimento dos trabalhos de Durkheim. Na segunda, tomando como referencial a obra de Burrell e Morgan (1979, é estudado o paradigma funcionalista em termos de sua origem e expoentes, com destaque para Comte e Spencer, visando chegar a uma compreensão inicial do pensamento de Durkheim e de sua sociologia. Na terceira, a vida e as principais obras de Durkheim são sumariadas e discutidas. Por fim, o status atual dos estudos organizacionais -vistos como um conjunto impreciso, elástico e eclético de teorias e pesquisas sociais voltados para os problemas das organizações -é analisado em termos de seus pressupostos epistemológicos e ontológicos subjacentes, como meio de explicitar a supremacia dos enfoques positivistas-funcionalistas.

  8. Zinc regulates iNOS-derived nitric oxide formation in endothelial cells

    Directory of Open Access Journals (Sweden)

    Miriam M. Cortese-Krott

    2014-01-01

    Full Text Available Aberrant production of nitric oxide (NO by inducible NO synthase (iNOS has been implicated in the pathogenesis of endothelial dysfunction and vascular disease. Mechanisms responsible for the fine-tuning of iNOS activity in inflammation are still not fully understood. Zinc is an important structural element of NOS enzymes and is known to inhibit its catalytical activity. In this study we aimed to investigate the effects of zinc on iNOS activity and expression in endothelial cells. We found that zinc down-regulated the expression of iNOS (mRNA+protein and decreased cytokine-mediated activation of the iNOS promoter. Zinc-mediated regulation of iNOS expression was due to inhibition of NF-κB transactivation activity, as determined by a decrease in both NF-κB-driven luciferase reporter activity and expression of NF-κB target genes, including cyclooxygenase 2 and IL-1β. However, zinc did not affect NF-κB translocation into the nucleus, as assessed by Western blot analysis of nuclear and cytoplasmic fractions. Taken together our results demonstrate that zinc limits iNOS-derived high output NO production in endothelial cells by inhibiting NF-κB-dependent iNOS expression, pointing to a role of zinc as a regulator of iNOS activity in inflammation.

  9. iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants.

    Science.gov (United States)

    Cassini-Vieira, Puebla; Araújo, Fernanda Assis; da Costa Dias, Filipi Leles; Russo, Remo Castro; Andrade, Silvia Passos; Teixeira, Mauro Martins; Barcelos, Luciola Silva

    2015-01-01

    There is considerable interest in implantation techniques and scaffolds for tissue engineering and, for safety and biocompatibility reasons, inflammation, angiogenesis, and fibrosis need to be determined. The contribution of inducible nitric oxide synthase (iNOS) in the regulation of the foreign body reaction induced by subcutaneous implantation of a synthetic matrix was never investigated. Here, we examined the role of iNOS in angiogenesis, inflammation, and collagen deposition induced by polyether-polyurethane synthetic implants, using mice with targeted disruption of the iNOS gene (iNOS(-/-)) and wild-type (WT) mice. The hemoglobin content and number of vessels were decreased in the implants of iNOS(-/-) mice compared to WT mice 14 days after implantation. VEGF levels were also reduced in the implants of iNOS(-/-) mice. In contrast, the iNOS(-/-) implants exhibited an increased neutrophil and macrophage infiltration. However, no alterations were observed in levels of CXCL1 and CCL2, chemokines related to neutrophil and macrophage migration, respectively. Furthermore, the implants of iNOS(-/-) mice showed boosted collagen deposition. These data suggest that iNOS activity controls inflammation, angiogenesis, and fibrogenesis in polyether-polyurethane synthetic implants and that lack of iNOS expression increases foreign body reaction to implants in mice.

  10. Zinc regulates iNOS-derived nitric oxide formation in endothelial cells

    Science.gov (United States)

    Cortese-Krott, Miriam M.; Kulakov, Larissa; Opländer, Christian; Kolb-Bachofen, Victoria; Kröncke, Klaus-D.; Suschek, Christoph V.

    2014-01-01

    Aberrant production of nitric oxide (NO) by inducible NO synthase (iNOS) has been implicated in the pathogenesis of endothelial dysfunction and vascular disease. Mechanisms responsible for the fine-tuning of iNOS activity in inflammation are still not fully understood. Zinc is an important structural element of NOS enzymes and is known to inhibit its catalytical activity. In this study we aimed to investigate the effects of zinc on iNOS activity and expression in endothelial cells. We found that zinc down-regulated the expression of iNOS (mRNA+protein) and decreased cytokine-mediated activation of the iNOS promoter. Zinc-mediated regulation of iNOS expression was due to inhibition of NF-κB transactivation activity, as determined by a decrease in both NF-κB-driven luciferase reporter activity and expression of NF-κB target genes, including cyclooxygenase 2 and IL-1β. However, zinc did not affect NF-κB translocation into the nucleus, as assessed by Western blot analysis of nuclear and cytoplasmic fractions. Taken together our results demonstrate that zinc limits iNOS-derived high output NO production in endothelial cells by inhibiting NF-κB-dependent iNOS expression, pointing to a role of zinc as a regulator of iNOS activity in inflammation. PMID:25180171

  11. 78 FR 49305 - Luminant Generation Company LLC, Comanche Peak Nuclear Power Plant, Unit Nos. 1 and 2...

    Science.gov (United States)

    2013-08-13

    ... NUCLEAR REGULATORY COMMISSION [Docket Nos. 50-445 and 50-446; NRC-2013-0182] Luminant Generation Company LLC, Comanche Peak Nuclear Power Plant, Unit Nos. 1 and 2; Application for Amendment to Facility... Operating License Nos. NPF-87 and NPF-89 for the Comanche Peak Nuclear Power Plant, Unit Nos. 1 and 2...

  12. Crianças usuárias de lente de contato nos serviços público e privado: análise comparativa Pediatric contact lens users in public and private services: comparative analysis

    Directory of Open Access Journals (Sweden)

    Daniela Araújo Toscano

    2009-04-01

    Full Text Available OBJETIVOS: Analisar as indicações, tipo, complicações do uso de lentes de contato e acuidade visual em crianças de serviços de Oftalmologia público e privado. MÉTODOS: Os dados dos prontuários de 59 crianças usuárias de lentes de contato em serviço privado (Hospital de Olhos de Pernambuco - Grupo 1, e 43 no serviço público (Fundação Altino Ventura - Grupo 2, foram analisados. A coleta de dados incluiu características sociodemográficas, idade da primeira consulta, indicação do uso da lente, tipo de lente, complicações e acuidade visual. RESULTADOS: As mais comuns indicações do uso de lente de contato no grupo 1 foram: ametropia (55,9%, anisometropia (18,6% e esotropia (16,9%. Neste grupo o leucoma e phthisis não estavam presentes. No grupo 2, as indicações mais comuns foram: anisometropia (23,2%, ametropia e leucoma (18,6% cada, e phthisis (16,3%. A esotropia não apareceu no grupo 2. O tipo de lente de contato mais prescrita foi a gelatinosa de uso permanente (não descartável no grupo 1 (45,8% e no grupo 2 (32,6%. A complicação mais encontrada no grupo 1 foi desconforto (33,3% e no grupo 2 perda da lente (60%. CONCLUSÕES: A indicação de ametropia predominou nos pacientes privados e as anisometropias nos públicos. O tipo de lente de contato mais prescrita nos dois grupos foi a gelatinosa de uso permanente. A complicação mais frequente no grupo 1 foi desconforto e no grupo 2 perda da lente. A acuidade visual na maioria dos pacientes manteve-se.PURPOSE: To analyze the indications, type and complications of contact lens use and visual acuity in children, in ophthalmological, public and private, services. METHODS: The information from the medical records of 59 contact lens users at a private service (Hospital de Olhos de Pernambuco - Recife - PE- Brazil - group 1, and 43 at public service (Fundação Altino Ventura - Recife - PE - Brazil - group 2, was analyzed. The collected data included: demographic information

  13. Changes of serum NO/iNOS after whole abdominal irradiation in rats

    International Nuclear Information System (INIS)

    Lin Hong; Wu Wei; Zhang Kunhe; Chen Jiang; Wang Yang; Luo Hui; Huang Xiaoqing

    2004-01-01

    Objective: To observe the changes of serum NO/NOS concentrations in rats after whole abdominal irradiation and their relationships with intestinal radiation injury. Methods: Thirty health rats were randomly divided into three groups: normal control group, irradiation control group, and IgY protection group. The sera of rats were collected and the NO and iNOS were assayed. Results: NO and iNOS levels increased evidently in the irradiation control group in contrast with those of the normal control group (P<0.01). NO and iNOS levels increased slightly in the IgY protection group in contrast with the irradiation control group (P<0.01) and were close to the levels of the normal control group. The changes of NO and NOS concentrations were synchronous. Conclusion: NO and iNOS are good indices for detecting intestinal radiation injury. (authors)

  14. Avaliação da qualidade das águas subterrâneas em áreas de preservação permanente (sistema aquífero guarani – sag, bacia hidrográfica do Rio Pardo, RS, Brasil

    Directory of Open Access Journals (Sweden)

    Adilson Ben da Costa

    2010-01-01

    Full Text Available O objetivo principal deste estudo foi avaliar a qualidade das águas subterrâneas em áreas de preservação permanente (SistemaAqüífero Guarani – SAG da Bacia Hidrográfica do Rio Pardo, RS, Brasil, através de variáveis físicas, químicas emicrobiológicas, tendo como base a resolução nº 396 do Conselho Nacional do Meio Ambiente – CONAMA. Nove pontos decoleta foram distribuídos ao longo da bacia, nos quais as águas subterrâneas foram classificadas quanto aos íons de maiorocorrência quantitativa através do diagrama de Piper. Os resultados indicaram que a maioria dos poços avaliados enquadraram-sena Classe 4 de usos da água, correspondendo a águas de usos menos restritivos. Entretanto, deve-se considerar que os aquíferos seapresentam em diferentes contextos geológicos, e que possuem características físicas, químicas e biológicas intrínsecas, comvariações hidrogeoquímicas, sendo necessário que as suas classes de qualidade sejam pautadas nessas especificidades, como seobservou no diagrama de Piper, onde as amostras P1, P2, P3, P5 e P9 classificaram-se como bicarbonatadas cálcicas, as águas dospontos P4, P6, P7 como bicarbonatadas sódicas e P8 se classificou como sulfatada. Verificou-se que a qualidade das águas depoços com profundidade inferior a 6 m está mais vulnerável devido a alterações antrópicas em função da concentração de nitrato,coliformes totais e termotolerantes, enquanto que a qualidade das águas de poços mais profundos depende basicamente de suascaracterísticas hidrogeológicas e hidrogeoquímicas naturais, em função das variáveis sulfato e sódio. Contudo, tambémapresentaram contaminação por atividade antrópica, principalmente pela variável nitrato.Abstract The aim of this research was to evaluate thequality of groundwater in areas of permanent preservation(Guarani Aquifer System – GAS in the Rio PardoHydrographical Basin, RS, Brazil, using physical, chemicaland

  15. Educação permanente com agentes comunitários de saúde: uma proposta de cuidado com crianças asmáticas Continuing education with community health agents: a proposal for care of asthmatic children

    Directory of Open Access Journals (Sweden)

    Maria Wanderleya de Lavor Coriolano

    2012-06-01

    Full Text Available O uso de metodologias ativas nos processos de formação dos trabalhadores de saúde é uma diretriz recomendada na Política Nacional de Educação Permanente em Saúde (PNEPS para trabalhadores do Sistema Único de Saúde (SUS. Neste estudo, formulou-se uma intervenção educativa para agentes comunitários de saúde (ACS sobre cuidados dirigidos a crianças/famílias com asma. O objetivo é descrever uma ação educativa com agentes comunitários de saúde sobre conhecimentos relacionados à asma, adotando as diretrizes da PNEPS no contexto da atenção primária. Tratase de estudo 'quantiqualitativo', com avaliação préteste e pósteste autopreenchida pelos agentes comunitários de saúde, além de metodologias ativas em três grupos focais vivenciais, que tiveram sua trajetória gravada e transcrita para posterior análise de dados, com uso da técnica análise de conteúdo na modalidade temática proposta por Bardin. Os conhecimentos dos ACS sobre mitos relacionados à asma apontaram acréscimo após a ação educativa. Dos grupos focais emergiram as temáticas: Educação em saúde para prevenção das doenças respiratórias; Significado atribuído à asma; Bombinhas: desmistificando conceitos; Fatores desencadeantes para asma; Adaptando cuidados preventivos; Avaliando os conhecimentos construídos. A utilização de metodologias ativas favoreceu o desenvolvimento de competências por parte dos ACS, despertando motivação na abordagem educativa junto às crianças/famílias com asma.The use of active methods in the health worker training process is a guideline that is recommended under the National Continuing Education in Health Policy (PNEPS for National Health System (SUS employees. In this study, the authors created an educational intervention for community health agents (CHA regarding care aimed at children/families with asthma. The aim is to describe an educational action involving community health workers about asthmarelated

  16. Construção de descritores para o processo de educação permanente em atenção básica Building descriptors for the permanent basic care education process

    Directory of Open Access Journals (Sweden)

    Rosita Saupe

    2007-11-01

    Full Text Available Educação permanente e atenção básica fazem parte do sistema de saúde brasileiro desde suas origens. Recentemente estas políticas públicas foram atualizadas, gerando um movimento inovador de construção de conhecimento visando apoiar sua implementação e consolidação. Este estudo, através de uma metodologia quantitativa, procurou evidenciar os principais descritores que devem orientar os processos de educação permanente em atenção básica. O método é originário da Universidade da Carolina do Norte. É desenvolvido em duas etapas. Os dados apresentados neste artigo dizem respeito à primeira etapa, que inclui as seguintes fases: elaboração de um diagrama com todos os componentes a serem avaliados; sua análise por um grupo de especialistas, indicando o que deve ser mantido, retirado ou incluído; avaliação por juízes, utilizando escala Likert de 1 a 5; verificação da concordância entre os juízes. O diagrama foi decomposto em quatro dimensões, procurando responder as seguintes questões: para quem? - audiências ou população alvo; o quê? - módulos de conteúdos e experiências de aprendizagem; para quê? - competências a serem desenvolvidas; e como? - metodologia a ser priorizada. Os resultados evidenciaram a procedência dos descritores propostos e avaliados, constituindo em material que pode contribuir para a tomada de decisão sobre educação permanente em atenção básica.Permanent education and basic care have been part of the Brazilian health system from the beginning. These public policies were recently updated, leading to an innovative knowledge construction movement to support their implementation and consolidation. This study, which used a quantitative approach, attempted to single-out the main descriptors that must guide the permanent basic care education processes. The method originated at the University of North Carolina and is carried out in two stages. The data shown in this article concern the

  17. Circulating Blood eNOS Contributes to the Regulation of Systemic Blood Pressure and Nitrite Homeostasis

    Science.gov (United States)

    Wood, Katherine C.; Cortese-Krott, Miriam M.; Kovacic, Jason C.; Noguchi, Audrey; Liu, Virginia B.; Wang, Xunde; Raghavachari, Nalini; Boehm, Manfred; Kato, Gregory J.; Kelm, Malte; Gladwin, Mark T.

    2013-01-01

    Objective Mice genetically deficient in endothelial nitric oxide synthase (eNOS−/−) are hypertensive with lower circulating nitrite levels, indicating the importance of constitutively produced nitric oxide (NO•) to blood pressure regulation and vascular homeostasis. While the current paradigm holds that this bioactivity derives specifically from expression of eNOS in endothelium, circulating blood cells also express eNOS protein. A functional red cell eNOS that modulates vascular NO• signaling has been proposed. Approach and Results To test the hypothesis that blood cells contribute to mammalian blood pressure regulation via eNOS-dependent NO• generation, we cross-transplanted WT and eNOS−/− mice, producing chimeras competent or deficient for eNOS expression in circulating blood cells. Surprisingly, we observed a significant contribution of both endothelial and circulating blood cell eNOS to blood pressure and systemic nitrite levels, the latter being a major component of the circulating NO• reservoir. These effects were abolished by the NOS inhibitor L-NAME and repristinated by the NOS substrate L-Arginine, and were independent of platelet or leukocyte depletion. Mouse erythrocytes were also found to carry an eNOS protein and convert 14C-Arginine into 14C-Citrulline in a NOS-dependent fashion. Conclusions These are the first studies to definitively establish a role for a blood borne eNOS, using cross transplant chimera models, that contributes to the regulation of blood pressure and nitrite homeostasis. This work provides evidence suggesting that erythrocyte eNOS may mediate this effect. PMID:23702660

  18. GEOPROCESSAMENTO APLICADO NO DIAGNÓSTICO DOS CONFLITOS DE USO E OCUPAÇÃO DO SOLO EM ÁREAS DE PRESERVAÇÃO PERMANENTE NO RIBEIRÃO DAS AGULHAS – BOTUCATU (SP

    Directory of Open Access Journals (Sweden)

    Sérgio Campos et al.

    2017-03-01

    Las Áreas de Preservación Permanente (APP tienen una función ambiental para preservar los recursos naturales, la biodiversidad, el flujo genético de fauna y flora, el suelo y la seguridad del bienestar de las poblaciones humanas. La degradación de los bosques ribereños contribuye a la sedimentación e incremento en la turbidez del agua, a la erosión de las orillas de los cursos de agua y al transporte de sustancias contaminantes, como pesticidas y fertilizantes agrícolas. El trabajo tuvo como objetivo determinar el uso incorrecto de las áreas de preservación permanente de la cuenca del río das Agulhas – Botucatu (SP, basada en la carta planialtimétrica de Botucatu y la imagen de satélite de 2011. La metodología consistió en el uso de GIS-IDRISI Selva para la georreferenciación, la generación de los amortiguamientos de las APPs y la superposición de los conflictos de uso y ocupación. El gran uso de la cuenca se correspondió con pastizales, 675,34ha. Las APPs (166,10ha se utilizan inadecuadamente, con 93, 33ha de pastizales. El diagnóstico indica la necesidad de un plan de protección vinculado al medio ambiente, y destinado a la recuperación de áreas degradadas, que permita la regeneración de la cubierta natural de las APPs, que se utilizan sin cumplir con la legislación ambiental brasileña. Las geotecnologías fueron herramientas indispensables para el diagnóstico del uso y ocupación del suelo en el área analizada. Palabras clave: SIG; Uso y Ocupación del Suelo; Preservación del Medio Ambiente.

  19. Crime e castigo nos Estados Unidos: de Nixon a Clinton

    Directory of Open Access Journals (Sweden)

    Loïc Wacquant

    1999-11-01

    Full Text Available Este artigo analisa o crescimento exponencial do número de detentos ocorrido nos Estados Unidos a partir de meados dos anos 70. Procura mostrar que esse crescimento não corresponde a um aumento da criminalidade, mas à conjugação de três séries causais, quais sejam: o declínio do "ideal de reabilitação" dos prisioneiros, a instrumentalização do medo da violência pelos políticos e pela mídia e a função de mecanismo de controle racial assumido pelo sistema penal americano. Em suma, a hiperflação carcerária revela a contraface do enfraquecimento do Estado de Bem-Estar Social e a sua substituição por um Estado penal.

  20. A metodologia nos processos midiáticos

    OpenAIRE

    GOMES S. J, PEDRO GILBERTO

    2011-01-01

    Um grande desafio que temos hoje é a definiç ão e o estabelecimento do objeto da comunicaç ão. Este texto pretende discutir tanto a questão do objeto quando da metodologia nos processos mediáticos. Dizemos que o objeto precede ao método. Não podemos escolher um método se não se coñ éese o objeto. Para isso realiza um pequeno recorrido sobre o problema do método nas ciencias sociais e sua relaç ão com o objeto. A importância dessa discussão no âmbito da comunicaç ão está relacionada com o prob...

  1. Technical Specifications, Braidwood Station, Unit Nos. 1 and 2 (Docket Nos. STN 50-456 and STN 50-457). Appendix ''A'' to License No. NPF-59

    International Nuclear Information System (INIS)

    1986-10-01

    Information is presented for Braidwood Station Unit Nos. 1 and 2 in the areas of: safety limits and limiting safety system settings; limiting conditions for operation and surveillance requirements; design features; and administrative controls

  2. Crataegus Special Extract WS 1442 Effects on eNOS and microRNA 155.

    Science.gov (United States)

    Wang, Xinwen; Liang, Yan; Shi, Jian; Zhu, Hao-Jie; Bleske, Barry E

    2018-04-16

    Increased expression of microRNA 155 (miR-155) results in a decrease in endothelial nitric oxide synthase (eNOS) expression and impaired endothelial function. Factors that have been shown to increase expression of miR-155 may be mitigated by WS 1442, an extract of hawthorn leaves and flowers ( Crataegus special extract) that contains a range of pharmacologically active substances including oligomeric proanthocyanidins and flavonoids. The purpose of this study is to determine the effect of WS 1442 on the expression of miR-155 and eNOS in the presence of tumor necrosis factor (TNF- α ). Human umbilical vein endothelial cells (HUVECs) were studied after the exposure to TNF- α , with or without simvastatin (positive control) and WS 1442. The expression levels of eNOS, phosphorylated eNOS, and miR-155 in the different HUVEC treatment groups were determined by western blot and quantitative real-time polymerase chain reaction, respectively. To evaluate the effect of WS 1442 on the eNOS activity, the medium and intracellular nitrate/nitrite (NO) concentrations were also analyzed using a colorimetric Griess assay kit. The results demonstrated that TNF- α upregulated miR-155 expression and decreased eNOS expression and NO concentrations. WS 1442 also increased miR-155 expression and decreased eNOS expression but, unlike TNF- α , increased phosphorylated eNOS expression and NO concentrations. Surprisingly, WS 1442 increased miR-155 expression; however, WS 1442 mitigated the overall negative effect of miR-155 on decreasing eNOS expression by increasing expression of phosphorylated eNOS and resulting in an increase in NO concentrations. In the setting where miR-155 may be expressed, WS 1442 may offer vascular protection by increasing the expression of phosphorylated eNOS. Georg Thieme Verlag KG Stuttgart · New York.

  3. Expression of beta-catenin, COX-2 and iNOS in colorectal cancer: relevance of COX-2 adn iNOS inhibitors for treatment in Malaysia.

    Science.gov (United States)

    Hong, Seok Kwan; Gul, Yunus A; Ithnin, Hairuszah; Talib, Arni; Seow, Heng Fong

    2004-01-01

    Promising new pharmacological agents and gene therapy targeting cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) could modulate treatment of colorectal cancer in the future. The aim of this study was to elucidate the expression fo beta-catenin and teh presence of COX-2 and iNOS in colorectal cancer specimens in Malaysia. This is a useful prelude to future studies investigating interventions directed towards COX-2 adn iNOS. A cross-section study using retrospective data over a 2-year period (1999-2000) involved 101 archival, formalin-fixed, paraffin-embedded tissue samples of colorectal cancers that were surgically resected in a tertiary referral. COX-2 production was detected in adjacent normal tissue in 34 sample (33.7%) and in tumour tissue in 60 samples (59.4%). More tumours expressed iNOS (82/101, 81.2%) than COX-2. No iNOS expression was detected in adjacent normal tissue. Intense beta-catenin immunoreactivity at the cell-to-cell border. Poorly differentiated tumours had significantly lower total beta-catenin (p = 0.009) and COX-2 scores (p = 0.031). No significant relationships were established between pathological stage and beta-catenin, COX-2 and iNOS scores. the accumulation of beta-catenin does not seem to be sufficient to activate pathways that lead to increased COX-2 and iNOS expression. A high proportion of colorectal cancers were found to express COX-2 and a significant number produced iNOS, suggesting that their inhibitors may be potentially useful as chemotherapeutic agents in the management of colorectal cancer.

  4. Diagnóstico ambiental e delimitação de Áreas de Preservação Permanente em um assentamento rural = Environmental diagnosis and delimitation of PPAs (Permanent Preservation Areas in a rural settlement

    Directory of Open Access Journals (Sweden)

    Nelson Alexandre Fagundes

    2008-01-01

    Full Text Available Leia-se neste artigo a tentativa de diagnosticar, delimitar e situar as Áreas de Preservação Permanentes e de Reserva Legal dentro de um assentamento rural, do Incra; visando à experimentação de ferramentas de geoprocessamento para a restauração das matas ribeirinhas, pela delimitação destas áreas, respeitando a legislação ambiental vigente, e partindo de uma ampla avaliação ambiental descritiva da paisagem, encontrada no Projeto de Assentamento Federal Capela. Um diagnóstico da paisagem local é apresentado na forma de um memorial fotográfico. Neste trabalho, serão delimitadas e quantificadas somente asAPP’s de entorno de corpos d’água.This article aims to diagnose, demarcate and situate Permanent Preservation Areas and Legal Reserves within an Incra Rural Settlement. This effort was conducted while testing the effective application of geoprocessing tools in the restoration of riparian forests and the delimitation of these areas, in accordance withexisting environmental legislation, and based on a broad descriptive environmental evaluation of the local landscape, located at the Capela Federal Settlement Project. A landscape diagnosis is shown in a photographic memorial as well. For this study, only the PPAs surrounding water bodies will be delimited and quantified.

  5. Las redes sociales en los procesos de adaptación a cambios permanentes de hábitat* Un estudio con habitantes de la Depresión Momposina (Norte de Colombia

    Directory of Open Access Journals (Sweden)

    Gabriel Garrido Escudero

    2001-01-01

    Full Text Available En este artículo se describen las redes sociales durante los procesos de adaptación a los permanentes cambios que viven los pobladores de la Depresión Momposina en La Travesía, corregimiento de Mompox (Colombia. La información se recogió en una muestra de 262 personas, mediante la triangulación se compararon los resultados cuantitativos y los cuantitativos y se contrastó la información desde diversas estrategias para describir de mejor forma los fenómenos estudiados. Con base en lo encontrado se observa que las redes continúan teniendo funcionalidad y un alto grado de intensidad cuando los pobladores se desplazan de un lugar a otro, debido a la cercanía física, a la cercanía económica y a la cercanía emocional existente, lo cual hace patente la importancia de las redes como potenciadoras de desarrollo social en el contexto de la cultura anfibia.

  6. Endodoncia regenerativa: utilización de fibrina rica en plaquetas autóloga en dientes permanentes vitales con patología pulpar. Revisión narrativa de la literatura*

    Directory of Open Access Journals (Sweden)

    Tatiana Ramírez Giraldo

    2014-01-01

    Full Text Available Actualmente una de las mayores controversias en el tratamiento de dientes permanentes con diagnóstico de pulpitis está en la decisión de realizar una Terapia Pulpar Vital (TPV o un tratamiento convencional de conductos. Diferentes estudios han reportado que se pueden obtener resultados previsibles mediante la realización de una TPV. El éxito del tratamiento dependerá de una adecuada comprensión de la  biología pulpar, un estricto protocolo de tratamiento y una adecuada selección del caso. Con este fin, diferentes materiales han sido sugeridos. Recientemente se ha utilizado la Fibrina Rica en Plaquetas, biomaterial que cumple con propiedades biológicas para lograr una mayor rapidez y adecuada cicatrizacion del tejido. Es necesario desarrollar tratamientos dirigidos a preservar la vitalidad de la pulpa, evitando recurrir como primera opción al tratamiento convencional de conductos, teniendo como objetivo conservar o regenerar el complejo dentino pulpar.

  7. La formación permanente en competencia digital docente y la mejora de la calidad del centro educativo desde la perspectiva de los docentes: un estudio de caso

    Directory of Open Access Journals (Sweden)

    Mercè Gisbert Cervera

    2015-07-01

    Full Text Available La sociedad del s. XXI demanda sistemas educativos flexibles y con capacidad de adaptación constante, capaces de hacer frente a las necesidades formativas, en forma de competencias, propias de un ciudadano que utiliza las TIC de forma natural y habitual en su vida cotidiana. Para ello se precisa de docentes competentes digitales que puedan formar a estas nuevas generaciones de ciudadanos. La formación permanente en TIC de los maestros, además de necesaria, dado el carácter dinámico de la tecnología, es un elemento de mejora de la calidad institucional de los centros educativos. Este trabajo, realizado a partir de una investigación-acción, evidencia que el propio centro de trabajo es capaz de organizar y diseñar su plan de formación, como parte de un proceso más amplio de mejora de la calidad basado en la incorporación de las TIC. A la vez, gestiona los ejes articuladores de una estrategia formativa que facilita la transferencia de ésta a la actividad del docente y aumenta la calidad del centro como institución. 

  8. DELIMITAÇÃO E PROTEÇÃO DAS ÁREAS DE PRESERVAÇÃO PERMANENTE DE CHAPADAS: ESTUDO DE CASO DA MINERAÇÃO DE AREIA EM ENCOSTAS NO NORTE DE MINAS GERAIS

    Directory of Open Access Journals (Sweden)

    Vitor Vieira Vasconcelos

    2011-12-01

    Full Text Available A mineração de areia de encosta para construção civil, na região Norte de Minas Gerais, tem causado uma séria de conflitos sócio-ambientais. A Polícia Ambiental e os órgãos de licenciamento ambiental têm encontrado dificuldades técnicas e administrativas para lidar com a situação. Este artigo apresenta uma proposta de utilização de técnicas de geoprocessamento e topografia, integradas à interpretação do direito ambiental, com fins de abordar os problemas citados de forma mais eficiente. Enfatiza-se, especialmente, a delimitação e a proteção de Áreas de Preservação Permanente de bordas de chapadas, onde ocorre tipicamente a mineração de areia de encosta. Por fim, apresentam-se propostas que auxiliem na transição para um modelo mais sustentável da mineração para construção civil na Região Norte de Minas Gerais.

  9. Limites e possibilidades do ensino à distância (EaD na educação permanente em saúde: revisão integrativa

    Directory of Open Access Journals (Sweden)

    Adriane das Neves Silva

    2015-04-01

    Full Text Available Trata-se de um estudo sobre o uso do ensino a distância (EaD como uma estratégia de ensino na educação permanente em saúde (EPS, que teve como objetivo identificar e analisar os limites e possibilidades do uso da EaD na EPS. Estudo de revisão integrativa. O resultado aponta que a EaD é uma estratégia inovadora possível e potencial para a EPS, facilitando o desenvolvimento da aprendizagem dentro ou fora da instituição de saúde, porém é evidente a escassez de pesquisas na área. As limitações para a realização dos programas estão relacionadas à variável tempo, preparação para lidar com as tecnologias e importância do tutor como facilitador da aprendizagem. Conclui-se que o uso da EaD tem tido uma importante contribuição para o desenvolvimento dos recursos humanos em saúde, seja no processo de formação e/ou no processo contínuo de conhecimento.

  10. Endodoncia regenerativa: utilización de fibrina rica en plaquetas autóloga en dientes permanentes vitales con patología pulpar. Revisión narrativa de la literatura*

    Directory of Open Access Journals (Sweden)

    Tatiana Ramírez Giraldo

    2014-07-01

    Full Text Available Actualmente una de las mayores controversias en el tratamiento de dientes permanentes con diagnóstico de pulpitis está en la decisión de realizar una Terapia Pulpar Vital (TPV o un tratamiento convencional de conductos. Diferentes estudios han reportado que se pueden obtener resultados previsibles mediante la realización de una TPV. El éxito del tratamiento dependerá de una adecuada comprensión de la  biología pulpar, un estricto protocolo de tratamiento y una adecuada selección del caso. Con este fin, diferentes materiales han sido sugeridos. Recientemente se ha utilizado la Fibrina Rica en Plaquetas, biomaterial que cumple con propiedades biológicas para lograr una mayor rapidez y adecuada cicatrizacion del tejido. Es necesario desarrollar tratamientos dirigidos a preservar la vitalidad de la pulpa, evitando recurrir como primera opción al tratamiento convencional de conductos, teniendo como objetivo conservar o regenerar el complejo dentino pulpar.

  11. Qualidade física do solo em pomar de laranjeira no noroeste do paraná com manejo da cobertura permanente na entrelinha Soil physical quality in an orange orchard in northwestern parana as affected by groundcover management

    Directory of Open Access Journals (Sweden)

    Jonez Fidalski

    2007-06-01

    Full Text Available O tráfego de máquinas e a compactação do solo ocorrem próximo à copa das plantas de citros, aumentando as restrições físicas do solo ao crescimento das raízes. Estratégias de manejo incluem o uso de coberturas permanentes do solo nas entrelinhas de pomares de laranjeira, mas são desconhecidos os seus efeitos na qualidade física do solo. O objetivo deste estudo foi quantificar o impacto de sistemas de manejo com cobertura permanente do solo em alguns indicadores de qualidade física do solo em um pomar de laranjeira. O estudo foi realizado em um experimento de longa duração de laranjeira 'Pêra' sobre limoeiro 'Cravo' com sistemas de cobertura permanente do solo nas entrelinhas, no município de Alto Paraná, noroeste do Paraná, em um Argissolo Vermelho distrófico latossólico, com horizonte superficial de textura arenosa. Os tratamentos de cobertura permanente nas entrelinhas com a gramínea mato-grosso ou batatais (Paspalum notatum manejada com roçada e a leguminosa amendoim forrageiro (Arachis pintoi foram comparados ao manejo tradicional, em que a vegetação espontânea foi dessecada com herbicida pós-emergente. O delineamento experimental utilizado foi de bloco ao acaso com três repetições. Em maio de 2003, a amostragem de solo foi realizada sob rodado e entrerrodado das máquinas nas entrelinhas do pomar. As amostras indeformadas de solo obtidas no centro da camada de 0-15 cm de profundidade foram utilizadas para determinação dos seguintes indicadores: conteúdo de água na capacidade de campo, porosidade total do solo e densidade do solo, a partir dos quais foram estimados os indicadores capacidade de aeração do solo e capacidade de armazenamento de água do solo. Amostras de solo deformadas foram coletadas nas camadas de 0-5 e 10-15 cm de profundidade, para determinação dos teores de C orgânico do solo e cálculo da taxa de estratificação de C orgânico do solo. Os indicadores de qualidade do solo

  12. Transgressões no campo da Ciência da Informação: abordagens de uma prática científica em permanente constituição

    Directory of Open Access Journals (Sweden)

    Meri Nadia Marques Gerlin

    2017-04-01

    Full Text Available O estudo apresenta conceitos ligados à disciplinaridade no campo da Ciência da Informação, assim como, inicia uma discussão em torno da natureza interdisciplinar dessa ciência atravessada pela transgressão metodológica. Reflete sobre a capacidade de interação com outras disciplinas que a atravessam, buscando, com isso, obter soluções de problemas perante a composição de seu objeto: a informação. Para tanto, dialoga-se com autores como Le Coadic, Bicalho e Oliveira, Francelin, Japiassú, Marques, Morin, Pinheiro, Tálamo e Smit. Considera-se que compreender como se deram as transgressões disciplinares no campo da Ciência da Informação torna-se condição essencial para dar conta de pensar a relação inter, multi e, principalmente, transdisciplinar necessária à manutenção de uma prática científica em permanente constituição.

  13. MECANISMOS DE GERAÇÃO DE ESCOAMENTO E ÁREAS HIDROLOGICAMENTE SENSÍVEIS: UMA ABORDAGEM HIDROGEOMORFOLÓGICA PARA DELIMITAÇÃO DE ÁREAS DE PRESERVAÇÃO PERMANENTE

    Directory of Open Access Journals (Sweden)

    Cesar Augusto Crovador SIEFERT

    2012-03-01

    Full Text Available Este artigo apresenta uma revisão conceitual sobre a relação entre os mecanismos de geração de escoamento e as áreas hidrologicamente sensíveis (AHS. Propõe-se a aproximação do conceito de AHSs na delimitação de áreas de preservação permanente (APPs devido à capacidade de geração de escoamento superficial por saturação destas áreas, estabelecendo assim a transferência de sedimentos e poluentes incidentes à jusante em direção aos canais. Reconhece-se a importância das AHSs como um novo paradigma na delimitação de APPs de acordo com características hidrogeomorfológicas da bacia hidrográfica. Por fim, observa-se ainda a necessidade de um aprofundamento na busca de um indicador de sensibilidade hidrológica das paisagens que possa ser utilizado em bacias hidrográficas com distintas características fisiográficas.

  14. Implementación de un mantenimiento basado en la condición usando modelado y simulación: caso de estudio de un motor sin-crónico de imanes permanentes

    Directory of Open Access Journals (Sweden)

    Jabid Quiroga Méndez

    2011-05-01

    Full Text Available Este artículo introduce la arquitectura de un CBM (mantenimiento basado en la condición en una aplicación eléctrica. La detección de fallas de manera oportuna y eficiente constituye uno de los retos más importantes asociados al CBM y el enfoque basado en modelos en el medio para conseguirlo. Un caso de estudio en un motor sincrónico de imanes permanentes (PMSM es ejecutado para ilustrar cómo el modelado es utilizado en la implementación de un CBM. El monitoreo fue implementado en tiempo real usando Matlab® y dSpace®. Se emplea como indicadora de falla la diferencia entre los valores de la componente secuencial negativa para las corrientes predichas usando una red neuronal multicapa y la corriente obtenida del motor. Resultados experimentales demostraron la efectividad del modelo propuesto en la detección de la falla de cortocircuito en el estator en distintos niveles de severidad y carga, obteniendo una confiabilidad en la detección mayor al 95%.

  15. Asiatic Acid Alleviates Hemodynamic and Metabolic Alterations via Restoring eNOS/iNOS Expression, Oxidative Stress, and Inflammation in Diet-Induced Metabolic Syndrome Rats

    Directory of Open Access Journals (Sweden)

    Poungrat Pakdeechote

    2014-01-01

    Full Text Available Asiatic acid is a triterpenoid isolated from Centella asiatica. The present study aimed to investigate whether asiatic acid could lessen the metabolic, cardiovascular complications in rats with metabolic syndrome (MS induced by a high-carbohydrate, high-fat (HCHF diet. Male Sprague-Dawley rats were fed with HCHF diet with 15% fructose in drinking water for 12 weeks to induce MS. MS rats were treated with asiatic acid (10 or 20 mg/kg/day or vehicle for a further three weeks. MS rats had an impairment of oral glucose tolerance, increases in fasting blood glucose, serum insulin, total cholesterol, triglycerides, mean arterial blood pressure, heart rate, and hindlimb vascular resistance; these were related to the augmentation of vascular superoxide anion production, plasma malondialdehyde and tumor necrosis factor-alpha (TNF-α levels (p < 0.05. Plasma nitrate and nitrite (NOx were markedly high with upregulation of inducible nitric oxide synthase (iNOS expression, but dowregulation of endothelial nitric oxide synthase (eNOS expression (p < 0.05. Asiatic acid significantly improved insulin sensitivity, lipid profiles, hemodynamic parameters, oxidative stress markers, plasma TNF-α, NOx, and recovered abnormality of eNOS/iNOS expressions in MS rats (p < 0.05. In conclusion, asiatic acid improved metabolic, hemodynamic abnormalities in MS rats that could be associated with its antioxidant, anti-inflammatory effects and recovering regulation of eNOS/iNOS expression.

  16. Expression profiles of eNOS, iNOS and microRNA-27b in the corpus cavernosum of rats submitted to chronic alcoholism and Diabetes mellitus.

    Science.gov (United States)

    Cunha, Joao Paulo da; Lizarte, Fermino Sanches; Novais, Paulo Cezar; Gattas, Daniela; Carvalho, Camila Albuquerque Mello de; Tirapelli, Daniela Pretti da Cunha; Molina, Carlos Augusto Fernandes; Tirapelli, Luis Fernando; Tucci, Silvio

    2017-01-01

    To evaluate the expression of endothelial and inducible NOS in addition to the miRNA-27b in the corpus cavernosum and peripheral blood of healthy rats, diabetic rats, alcoholic rats and rats with both pathologies. Forty eight Wistar rats were divided into four groups: control (C), alcoholic (A), diabetic (D) and alcoholic-diabetic (AD). Samples of the corpus cavernosum were prepared to study protein expressions of eNOS and iNOS by immunohistochemistry and expression of miRNA-27b in the corpus cavernosum and peripheral blood. Immunohistochemistry for eNOS and iNOS showed an increase in cavernosal smooth muscle cells in the alcoholic, diabetic and alcoholic-diabetic groups when compared with the control group. Similarly, the mRNA levels for eNOS were increased in cavernosal smooth muscle (CSM) in the alcoholic, diabetic and alcoholic-diabetic groups and miRNA-27b were decreased in CSM in the alcoholic, diabetic and alcoholic-diabetic groups. The major new finding of our study was an impairment of relaxation of cavernosal smooth muscle in alcoholic, diabetic, and alcoholic-diabetic rats that involved a decrease in the nitric oxide pathway by endothelium-dependent mechanisms accompanied by a change in the corpus cavernosum contractile sensitivity.

  17. NOS3 Variants, Physical Activity, and Blood Pressure in the European Youth Heart Study

    DEFF Research Database (Denmark)

    Grøntved, Anders; Andersen, Lars Bo; Franks, Paul W

    2011-01-01

    BackgroundIn this study, we examined the influence of genetic variation in NOS3 on resting blood pressure (BP) in children and adolescents from the European Youth Heart Study (EYHS). Because the NOS3 gene expression is altered by physical activity (PA), we also tested for interaction between...

  18. Suggesting a NOS Map for Nature of Science for Science Education Instruction

    Science.gov (United States)

    Oh, Jun-Young

    2017-01-01

    The aims of this research are 1) to explore the inter-relationships within the individual elements or tenets of Nature of Science (NOS), based on the dimensions of scientific knowledge in science learning, and 2) to consider Kuhn's concept of how scientific revolution takes place. This study suggests that instruction according to our NOS Flowchart…

  19. Association between nucleotide mutation of eNOS gene and serum ...

    African Journals Online (AJOL)

    Various mutation on endothelial nitric oxide synthase (eNOs) gene cause reduced production of NO, the expansion factor (VEF) and may accelerate the process of atherosclerosis. The study was designed to investigate the frequency of T-786C polymorphism of the gene or nucleotide mutation of eNOS gene in patients ...

  20. Complex posttraumatic stress disorder: an exploratory investigation of PTSD and DES NOS among Dutch war veterans

    NARCIS (Netherlands)

    Jongedijk, R. A.; Carlier, I. V.; Schreuder, B. J.; Gersons, B. P.

    1996-01-01

    The recently developed concept Disorder of Extreme Stress Not Otherwise Specified (DES NOS) or complex posttraumatic stress disorder (complex PTSD) is designed to encompass long-standing symptoms not present in PTSD. An exploratory investigation of PTSD and DES NOS was performed with the Structured

  1. Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus

    DEFF Research Database (Denmark)

    Harvey, Brian H; Oosthuizen, Frasia; Brand, Linda

    2004-01-01

    . The NOS isoform involved, and the role of stress-mediated corticosterone release in NOS activation, was verified with the administration of selective iNOS and nNOS inhibitors, aminoguanidine (50 mg/kg/day i.p.) and 7-nitroindazole (12.5 mg/kg/day i.p.), and the steroid synthesis inhibitor, ketoconazole...... (24 mg/kg/day i.p.), administered for 21 days prior to and during the stress procedure. RESULTS: Stress evoked a sustained increase in NOS activity, but reduced NMDA receptor density and total GABA levels. Aminoguanidine or ketoconazole, but not 7-nitroindazole or saline, blocked stress-induced NOS...

  2. Obesity, inflammation, and exercise training: relative contribution of iNOS and eNOS in the modulation of vascular function in the mouse aorta

    Directory of Open Access Journals (Sweden)

    Josiane Fernandes da Silva

    2016-09-01

    Full Text Available Background - The understanding of obsesity-related vascular dysfunction remains controversial mainly because of the diseases associated with vascular injury. Exercise training is known to prevent vascular dysfunction. Using an obesity model without comorbidities, we aimed at investigating the underlying mechanism of vascular dysfunction and how exercise interferes with this process.Methods - High-sugar diet was used to induce obesity in mice. Exercise training was performed 5 days/week. Body weight, energy intake, and adipose tissues were assessed; blood metabolic and hormonal parameters were determined; and serum TNFα was measured. Blood pressure and heart rate were assessed by plethysmography. Changes in aortic isometric tension were recorded on myograph. Western blot was used to analyze protein expression. Nitric oxide (NO was evaluated using fluorescence microscopy. Antisense oligodeoxynucleotides were used for inducible nitric oxide synthase isoform (iNOS knockdown.Results - Body weight, fat mass, total cholesterol, low-density lipoprotein cholesterol fraction, insulin, and leptin were higher in the sedentary obese group (SD than in the sedentary control animals (SS. Exercise training prevented these changes. No difference in glucose tolerance, insulin sensitivity, blood pressure, and heart rate was found. Decreased vascular relaxation and reduced endothelial nitric oxide synthase (eNOS functioning in the SD group were prevented by exercise. Contractile response to phenylephrine was decreased in the aortas of the wild SD mice, compared with that of the SS group; however, no alteration was noted in the SD iNOS-/- animals. The decreased contractility was endothelium-dependent, and was reverted by iNOS inhibition or iNOS silencing. The aortas from the SD group showed increased basal NO production, serum TNFα, TNF receptor-1, and phospho-IκB. Exercise training attenuated iNOS-dependent reduction in contractile response in high-sugar diet

  3. Phenotyping of nNOS neurons in the postnatal and adult female mouse hypothalamus.

    Science.gov (United States)

    Chachlaki, Konstantina; Malone, Samuel A; Qualls-Creekmore, Emily; Hrabovszky, Erik; Münzberg, Heike; Giacobini, Paolo; Ango, Fabrice; Prevot, Vincent

    2017-10-15

    Neurons expressing nitric oxide (NO) synthase (nNOS) and thus capable of synthesizing NO play major roles in many aspects of brain function. While the heterogeneity of nNOS-expressing neurons has been studied in various brain regions, their phenotype in the hypothalamus remains largely unknown. Here we examined the distribution of cells expressing nNOS in the postnatal and adult female mouse hypothalamus using immunohistochemistry. In both adults and neonates, nNOS was largely restricted to regions of the hypothalamus involved in the control of bodily functions, such as energy balance and reproduction. Labeled cells were found in the paraventricular, ventromedial, and dorsomedial nuclei as well as in the lateral area of the hypothalamus. Intriguingly, nNOS was seen only after the second week of life in the arcuate nucleus of the hypothalamus (ARH). The most dense and heavily labeled population of cells was found in the organum vasculosum laminae terminalis (OV) and the median preoptic nucleus (MEPO), where most of the somata of the neuroendocrine neurons releasing GnRH and controlling reproduction are located. A great proportion of nNOS-immunoreactive neurons in the OV/MEPO and ARH were seen to express estrogen receptor (ER) α. Notably, almost all ERα-immunoreactive cells of the OV/MEPO also expressed nNOS. Moreover, the use of EYFP Vglut2 , EYFP Vgat , and GFP Gad67 transgenic mouse lines revealed that, like GnRH neurons, most hypothalamic nNOS neurons have a glutamatergic phenotype, except for nNOS neurons of the ARH, which are GABAergic. Altogether, these observations are consistent with the proposed role of nNOS neurons in physiological processes. © 2017 Wiley Periodicals, Inc.

  4. Nos caminhos do pai: influências de Francisco Palmério na formação do escritor Mário Palmério

    Directory of Open Access Journals (Sweden)

    André Azevedo da Fonseca

    2011-12-01

    Full Text Available O artigo traça uma biografia de Francisco Palmério (1867-1947, pai do escritor mineiro Mário Palmério (1916-1996 – autor de Vila dos Confins (1956 e Chapadão do Bugre (1965. Através de fontes primárias e análise documental, a pesquisa desenvolve interpretações sobre as influências paternas de caráter moral, cultural, intelectual e profissional que marcaram a primeira geração da família Palmério no Brasil e, particularmente, condicionaram as experiências que mais tarde seriam ressignificadas na obra literária e na trajetória pessoal de Mário Palmério. Notamos que as permanentes viagens a trabalho do pai e as suas diversas atividades profissionais favoreceram uma consciência familiar das particularidades da região. Essa experiência favoreceu a criação de vínculos econômicos, políticos e afetivos com a cultura regional e estimulou nos filhos um profundo conhecimento histórico e geográfico do Oeste mineiro. Além disso, o pai parece ter exercido uma profunda influência sobre os filhos no que diz respeito ao gosto pela política regional. O artigo desenvolve a hipótese de que todas essas experiências foram elementos presentes na formação de Mário Palmério e, mais tarde, apareceriam de modo explícito em sua literatura marcada pela descrição da natureza, do cotidiano e das intrigas políticas regionalistas. Palavras-chave: Regionalismo; Literatura regionalista; Literatura mineira; Mário Palmério; Vila dos Confins; Chapadão do Bugre.

  5. Institucionalizacao da saude publica paulista nos anos 1930-1940

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    Andre Mota

    2013-10-01

    Full Text Available O objetivo do estudo foi interpretar e compreender a institucionalização da saúde pública paulista nos anos 1930-1940, com base na história das especialidades médicas. Foram analisadas novas fontes documentais em diálogo com a literatura existente, levando à identificação de novos indícios relativamente à questão eugênica e à presença de crenças religiosas de médicos como um movimento social. Os médicos, à medida que se especializavam como sanitaristas, propunham um projeto para elevar a raça brasileira, mesclando discursos higienistas com ações sanitárias. São Paulo buscou a primazia nesse projeto, por se acreditar um Estado detentor de uma raça já constituída de “homens historicamente saudáveis”. Crenças religiosas influenciaram o debate e as decisões de época para a ordem sanitária. Historicamente, o discurso sanitário compõe questões técnico-científicas com as político-ideológicas e as culturais, produzindo uma mescla dos diferentes interesses e perspectivas de ordem corporativa da profissão.

  6. Assédio moral nos ambientes corporativos

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    Yumara Lúcia Vasconcelos

    Full Text Available Resumo:Esse artigo teve como objetivo caracterizar o assédio moral nos ambientes corporativos à luz do paradigma conceitual do que se concebe como "dignidade humana" e violação do princípio jurídico da boa-fé. Especificamente, visou identificar padrões na argumentação jurídica e no enquadramento de práticas nocivas à saúde mental do trabalhador. O estudo, de natureza qualitativa, tomou por base o estudo de situações jurídicas, orientando-se pela demanda por definição e caracterização da prática assediadora no âmbito organizacional e dos limites do conceito da dignidade humana. Como principal resultado, o estudo colocou em contraste a necessidade de contextualização do fato propulsor da denúncia e caracterização do assédio, sem olvidar a relevância do significado ou sentido atribuído pelo indivíduo ao fenômeno analisado.

  7. Heterose em suínos na fase de aleitamento

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    José Bento Sterman Ferraz

    1991-12-01

    Full Text Available Visando avaliar o ganho de produtividade, advindo da heterose, no peso de suínos em fase de aleitamento, analisaram-se os pesos ao nascimento(PO, 21 dias de idade (P21 e desmama (PD de 746leitões, sendo 201 da raça Landrace, 136 Wessex-Saddleback e 409 mestiços, pelo método dos quadrados mínimos, considerando-se, ainda, os efeitos fixos de época e ano de nascimento, ordem do parto, sexo do leitão e tamanho da leitegada, além de raças paterna e materna e suas interações. Os efeitos não genéticos tiveram influência significativa em quase todas as características. Os mestiços mostraram, em geral, pesos superiores aos puros, com estimativas de heterose de 2,6% para PO, 9,7% para P21 e 13,9% para PD, indicando a importância da herança não aditiva à medida que os leitões ficam menos dependentes de suas mães. Os efeitos de interação entre as raças paterna e materna foram cada vez maiores com o avançar da idade. Os resultados indicam haver ganho de produtividade coma utilização deste tipo de cruzamento.

  8. Empirical support for a reclassification of eating disorders NOS.

    Science.gov (United States)

    Helverskov, J L; Lyng, B; Clausen, L; Mors, O; Frydenberg, M; Thomsen, P H; Rokkedal, K

    2011-01-01

    To explore the empirical support for a reclassification of the eating disorders NOS (EDNOS) category. In a cross-sectional design eight specific subgroups of EDNOS were compared to anorexia nervosa (AN) and bulimia nervosa (BN) on interview-based data and questionnaire measures. The sample consisted of 965 patients in the age 13-54 years admitted to treatment for an eating disorder. According to the DSM-IV 176(18%) presented with AN, 290(30%) with BN and 499(52%) with EDNOS. Of all EDNOS cases 34% could be reclassified as AN or BN. Three specific subgroups emerged as separate diagnostic entities. A heterogeneous subgroup of 122 patients (13% of all) was proposed as 'true' EDNOS. Implications of the results on the DSM-V are discussed. The results support a broader definition of AN and BN and suggest subgroups of EDNOS as separate diagnostic entities. This results in a substantial reduction of the heterogeneous EDNOS group. Copyright © 2010 John Wiley & Sons, Ltd and Eating Disorders Association.

  9. Identification of hamster inducible nitric oxide synthase (iNOS) promoter sequences that influence basal and inducible iNOS expression

    Science.gov (United States)

    Saldarriaga, Omar A.; Travi, Bruno L.; Choudhury, Goutam Ghosh; Melby, Peter C.

    2012-01-01

    IFN-γ/LPS-activated hamster (Mesocricetus auratus) macrophages express significantly less iNOS (NOS2) than activated mouse macrophages, which contributes to the hamster's susceptibility to intracellular pathogens. We determined a mechanism responsible for differences in iNOS promoter activity in hamsters and mice. The HtPP (1.2 kb) showed low basal and inducible promoter activity when compared with the mouse, and sequences within a 100-bp region (−233 to −133) of the mouse and hamster promoters influenced this activity. Moreover, within this 100 bp, we identified a smaller region (44 bp) in the mouse promoter, which recovered basal promoter activity when swapped into the hamster promoter. The mouse homolog (100-bp region) contained a cis-element for NF-IL-6 (−153/−142), which was absent in the hamster counterpart. EMSA and supershift assays revealed that the hamster sequence did not support the binding of NF-IL-6. Introduction of a functional NF-IL-6 binding sequence into the hamster promoter or its alteration in the mouse promoter revealed the critical importance of this transcription factor for full iNOS promoter activity. Furthermore, the binding of NF-IL-6 to the iNOS promoter (−153/−142) in vivo was increased in mouse cells but was reduced in hamster cells after IFN-γ/LPS stimulation. Differences in the activity of the iNOS promoters were evident in mouse and hamster cells, so they were not merely a result of species-specific differences in transcription factors. Thus, we have identified unique DNA sequences and a critical transcription factor, NF-IL-6, which contribute to the overall basal and inducible expression of hamster iNOS. PMID:22517919

  10. St36 electroacupuncture activates nNOS, iNOS and ATP-sensitive potassium channels to promote orofacial antinociception in rats.

    Science.gov (United States)

    Almeida, R T; Galdino, G; Perez, A C; Silva, G; Romero, T R; Duarte, I D

    2017-02-01

    Orofacial pain is pain perceived in the face and/or oral cavity, generally caused by diseases or disorders of regional structures, by dysfunction of the nervous system, or through referral from distant sources. Treatment of orofacial pain is mainly pharmacological, but it has increased the number of reports demonstrating great clinical results with the use of non-pharmacological therapies, among them electroacupuncture. However, the mechanisms involved in the electroacupuncture are not well elucidated. Thus, the present study investigate the involvement of the nitric oxide synthase (NOS) and ATP sensitive K + channels (KATP) in the antinociception induced by electroacupuncture (EA) at acupoint St36. Thermal nociception was applied in the vibrissae region of rats, and latency time for face withdrawal was measured. Electrical stimulation of acupoint St36 for 20 minutes reversed the thermal withdrawal latency and this effect was maintained for 150 min. Intraperitoneal administration of specific inhibitors of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS) and a KATP channels blocker reversed the antinociception induced by EA. Furthermore, nitrite concentration in cerebrospinal fluid (CSF) and plasma, increased 4 and 3-fold higher, respectively, after EA. This study suggests that NO participates of antinociception induced by EA by nNOS, iNOS and ATP-sensitive K + channels activation.

  11. Modelación y análisis de susceptibilidad a la deformación permanente de mezclas asfálticas Modeling and analysis of susceptibility to permanent deformation in asphalt mixtures

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    Julián Vidal V

    2011-08-01

    Full Text Available La deformación permanente de mezclas asfálticas del Área Metropolitana del Valle de Aburra - Antioquia, las cuales se fabrican en nuestro medio bajo las especificaciones INVIAS (Instituto Nacional de Vías y del Valle de Aburrá, se estudiaron utilizando un modelo constitutivo propuesto anteriormente. Este modelo mostró previamente ser efectivo en predecir la deformación de mezclas asfálticas en el Reino Unido bajo diferentes tipos de carga bajo condiciones uniaxiales y triaxiales, y temperaturas comprendidas entre 0 °C y 40 °C. Para el caso de las mezclas del Valle de Aburrá se emplearon temperaturas en un intervalo de 20 °C a 50 °C y se implementó el modelo propuesto con el fin de predecir la susceptibilidad a la deformación permanente. Mediante el estudio experimental de las mezclas se encontró que el comportamiento de estado estable de estas siguió el modelo modificado de Cross (Wang, 2011, con las mezclas exhibiendo comportamiento viscoso lineal y no-lineal a bajos y altos niveles de esfuerzos, respectivamente. Tanto para condiciones de carga como de recuperación se observó una dependencia de la temperatura en el material que fue adecuadamente predicha por el modelo de Arrheniusbajo el intervalo de temperaturas estudiado. Al realizar la modelación del comportamiento de las mezclas se encontró que el modelo propuesto por Ossa et al. (2010 aplica a las mezclas estudiadas y se determinó que la susceptibilidad a la deformación de estas varía considerablemente dependiendo de los materiales utilizados por el productor y en especial el agregado empleado, a pesar de ser mezclas teóricamente similares.Permanent deformation of asphaltic mixtures in the Metropolitan Area of Valle de Aburra - Antioquia, which are built under IVIAS' specifications (Instituto Nacional de Vías and Valle de Aburrá, were studied by employing a constitutive model proposed previously. This model had proved to be effective in predicting deformations of

  12. Electroacupuncture Delays Hypertension Development through Enhancing NO/NOS Activity in Spontaneously Hypertensive Rats

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    Hye Suk Hwang

    2011-01-01

    Full Text Available Using spontaneously hypertensive rats (SHR, this study investigated whether electroacupuncture (EA could reduce early stage hypertension by examining nitric oxide (NO levels in plasma and nitric oxide synthase (NOS levels in the mesenteric resistance artery. EA was applied to the acupuncture point Governor Vessel 20 (GV20 or to a non-acupuncture point in the tail twice weekly for 3 weeks under anesthesia. In conscious SHR and normotensive Wistar Kyoto (WKY rats, blood pressure was determined the day after EA treatment by the tail-cuff method. We measured plasma NO concentration, and evaluated endothelial NO syntheses (eNOS and neuronal NOS (nNOS protein expression in the mesenteric artery. Systolic blood pressure (SBP and diastolic blood pressure (DBP were lower after 3 weeks of GV20 treatment than EA at non-acupuncture point and no treatment control in SHR. nNOS expression by EA was significantly different between both WKY and no treatment SHR control, and EA at GV20 in SHR. eNOS expression was significantly high in EA at GV 20 compared with no treatment control. In conclusion, EA could attenuate the blood pressure elevation of SHR, along with enhancing NO/NOS activity in the mesenteric artery in SHR.

  13. Identification and molecular characterization of nitric oxide synthase (NOS) gene in the intertidal copepod Tigriopus japonicus.

    Science.gov (United States)

    Jeong, Chang-Bum; Kang, Hye-Min; Seo, Jung Soo; Park, Heum Gi; Rhee, Jae-Sung; Lee, Jae-Seong

    2016-02-10

    In copepods, no information has been reported on the structure or molecular characterization of the nitric oxide synthase (NOS) gene. In the intertidal copepod Tigriopus japonicus, we identified a NOS gene that is involved in immune responses of vertebrates and invertebrates. In silico analyses revealed that nitric oxide (NO) synthase domains, such as the oxygenase and reductase domains, are highly conserved in the T. japonicus NOS gene. The T. japonicus NOS gene was highly transcribed in the nauplii stages, implying that it plays a role in protecting the host during the early developmental stages. To examine the involvement of the T. japonicus NOS gene in the innate immune response, the copepods were exposed to lipopolysaccharide (LPS) and two Vibrio sp. After exposure to different concentrations of LPS and Vibrio sp., T. japonicus NOS transcription was significantly increased over time in a dose-dependent manner, and the NO/nitrite concentration increased as well. Taken together, our findings suggest that T. japonicus NOS transcription is induced in response to an immune challenge as part of the conserved innate immunity. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. Tratamento adjuvante nos GISTs Adjuvant treatment in GISTs

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    Laercio Gomes Lourenço

    2011-09-01

    Full Text Available INTRODUÇÃO: O tumor estromal gastrointestinal (GIST é o sarcoma mais comum do aparelho digestivo. Essa neoplasia ocorre devido à mutação do gene KIT com consequente ativação constitutiva da proteína KIT. O tratamento primário é cirúrgico e consiste na sua ressecção completa. Entretanto, alguns grupos de pacientes apresentam risco elevado de recorrência mesmo após operação com ressecção completa (R0, indicando diferenças no comportamento biológico. Estudos clínicos comprovaram a atividade clínica do mesilato de imatinibe, fazendo dele a primeira linha de tratamento padrão nos GISTs metastáticos ou irressecáveis, mudando muito o desfecho clínico dessa doença em relação aos benefícios anteriormente obtidos com a quimioterapia antineoplásica. MÉTODO: Foi realizada revisão da literatura com consulta nos periódicos das bases Medline/Pubmed, Scielo e Lilacs cruzando os descritores: tumor estromal gastrointestinal, Gist, tratamento, adjuvância. Além desta revisão foi adicionada a experiência pessoal dos autores. CONCLUSÃO: Melhor refinamento dos critérios de prognóstico tem permitido selecionar de forma mais adequada pacientes para o tratamento adjuvante com imatinibe. Os resultados de maior evidência até o momento respaldam o tratamento adjuvante por um ano, o que produz benefício significativo na sobrevida livre de recidiva, mas não na sobrevida global desses pacientes.INTRODUCTION: Gastrointestinal stromal tumor (GIST is the most common sarcoma of the digestive tract. This cancer occurs due to mutation of the KIT gene resulting in constitutive activation of KIT protein. The primary treatment is surgical and consists of complete resection. However, some groups of patients at high risk of recurrence even after surgery with complete resection (R0, indicate differences in biological behavior. Clinical studies have demonstrated the clinical activity of imatinib mesylate, making it the standard first

  15. MAPEAMENTO GEOMORFOLÓGICO DE DETALHE PARA DELIMITAÇÃO DE ÁREAS DE PRESERVAÇÃO PERMANENTE (APP DE ZONAS COSTEIRAS EM ATENDIMENTO AO CADASTRO AMBIENTAL RURAL (CAR

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    Anderson Targino da Silva Ferreira

    2016-12-01

    Full Text Available Este trabalho teve como objetivo apresentar a metodologia para o mapeamento de Áreas de Preservação Permanente (APP de zonas costeiras em atendimento ao Cadastro Ambiental Rural (CAR, adequada para escala de detalhe que exige o imóvel rural. A metodologia consistiu na geração do Modelo Digital de Elevação (MDE da zona costeira, a partir do posicionamento GNSS (Global Navigation Satellite Systems; no mapeamento das feições morfológicas costeiras, com reconhecimento in situ; e no atendimento à legislação ambiental vigente quanto às definições de APP. No controle de qualidade do MDE do estudo de caso, as discrepâncias entre as altitudes do modelo e as de referência tiveram erro médio quadrático de 0,047 m. No mapa de APP, o índice de exatidão kappa com valor de 83% indicou que a probabilidade das categorias mapeadas (40% de APP e 60% passível de uso terem sido classificadas corretamente representou uma avaliação muito boa, indicando a alta sensibilidade do mapa em classificar as unidades geomorfológicas do terreno. Os resultados obtidos mostraram que a metodologia empregada tem amplo potencial (acurácia, eficiência, rapidez e baixo custo na delimitação de APP de zonas costeiras em atendimento ao CAR, onde as feições morfológicas são normalmente de pequenas dimensões.

  16. FEIÇÕES GEOMORFOLÓGICAS, ÁREAS DE PRESERVAÇÃO PERMANENTE E IMPLANTAÇÃO DE MEGAPROJETO DE INFRAESTRUTURA URBANA/HOTELEIRA NA VIA COSTEIRA DE NATAL/RN

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    Marceu Melo

    2018-04-01

    Full Text Available O litoral do planeta sustenta diversas atividades econômicas, abriga grande parte da população mundial e é considerado ambiente de relativa fragilidade. O desenvolvimento da atividade turística no Rio Grande do Norte está diretamente associada ao litoral e adquiriu maior relevância no final da década de 1970 e início da década de 1980, no contexto da política dos megaprojetos turísticos, através da implantação do projeto Via Costeira em Natal, que objetivava ampliar a infraestrutura hoteleira da capital do estado. O projeto foi aprovado e parcialmente implantado, embora tenha sofrido diversas críticas e reformulações, sobretudo devido às características naturais da área proposta para sua instalação, composta majoritariamente por dunas móveis ou cobertas por vegetação do Bioma Mata Atlântica. O objetivo deste trabalho foi verificar quais elementos geomorfológicos foram afetados pela sua implantação e, a partir destes, delimitar as Áreas de Preservação Permanente (APPs definidas pela legislação. Os resultados demonstraram que o projeto foi realizado em quase sua totalidade sobre APPs. Concluímos que a medida mais adequada é declarar os trechos não ocupados como áreas non aedificandi e executar projetos de recuperação das áreas degradadas.

  17. Tipo de arcada y plano terminal molar de la dentición temporal y su correlación con las clases de maloclusión de la dentición permanente

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    Ana Pascual Serna

    2015-12-01

    Full Text Available El objetivo fue establecer la correlación del tipo de arcada y plano terminal molar de la dentición temporal con las clases de maloclusión de Angle en niños de 5 años de edad que acuden al Hospital Nacional “Daniel Alcides Carrión”de Cerro de Pasco, 2010 - 2011. La investigación se desarrolló bajo un diseño descriptivo longitudinal prospectivo. La muestra estuvo conformada por 40 niños escogidos por muestreo no probabilístico. Se realizó inicialmente la evaluación clínica del tipo de arcada y plano terminal molar de la dentición temporal y posteriormente al erupcionar las primeras molares permanentes se verificó la correlación con las clases de maloclusión de Angle, el tratamiento estadístico de la hipótesis fue con la Chi Cuadrada. Entre los resultados podemos mencionar que existe diferencia estadística significativa para asumir que el tipo de plano terminal molar y tipo de arcada de la dentición temporal se correlaciona con las clases de maloclusión de Angle, teniendo en consideración que la X2c=12,724>X2t = 9,488(4gl-95 %, rechazándose la Ho. En conclusión, el tipo de plano terminal molar recto y el tipo de arcada abierta de la dentición temporal se relaciona con mayor frecuencia con la normoclusión y la Clase I de maloclusión. Mientras que el tipo de plano terminal molar escalón mesial y el tipo de arcada cerrada de la dentición temporal se relaciona con la Clase III de maloclusión.

  18. La inclusión educativa de alumnos con discapacidades graves y permanentes en la Unión Europea. [Educational inclusion of students with severe and permanent disabilities in the European Union

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    López-Torrijo, Manuel

    2009-06-01

    Full Text Available This article presents a comparative study of the care of students with severe and permanent educational needs in the six EU countries with greater rates of educational inclusion, (Italy, Greece, Portugal, Norway, Cyprus and Iceland. Such study has been done bearing in mind the following indicators: Analysis of educational needs, identification of deficit, schooling of students in Specific Centres for Special Education, legislative frame, responsibility for schooling and rendering of services, frame and models of schooling, state and functions of Specific Centres of Special Education, curricula of the inclusion, Human resources, family role and funding. From the aforementioned lines are deduced the trends in policies and educational practices carried out are followed. Conclude the necessary changes for the improvement of the future educational educational inclusion. Este artículo presenta un estudio comparado de la atención realizada a los alumnos con discapacidades graves y permanentes en los seis países de la UE que presentan mayores índices de inclusión educativa (Italia, Grecia, Portugal, Noruega, Chipre e Islandia. Dicho estudio está realizado teniendo en cuenta los siguientes indicadores: concepción de las necesidades educativas especiales, identificación de los déficit, alumnado escolarizado en Centros Específicos de Educación Especial, marco legislativo, responsabilidad de escolarización y prestación de servicios, modelo y modalidades de escolarización, estado y funciones de los Centros Específicos de Educación Especial, currículo de la inclusión, recursos humanos, papel de las familias y financiación. De ahí se deducen las tendencias en las políticas y las prácticas educativas realizadas y se concluyen los cambios necesarios para mejorar la inclusión educativa en un futuro.

  19. (INTERSUBJETIVIDADE NOS ESTUDOS DE REDES SOCIAIS: DISSOLVENDO FRONTEIRAS

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    Sayonara Costa

    2014-07-01

    Full Text Available As redes sociais da internet (RSI se multiplicam e todas elas, embora tenham esquemas enunciativos distintos, ampliam as possibilidades de por em cena (intersubjetividades. Muitos papeis sociais são desempenhados nesses ambientes digitais que dão guarida às múltiplas faces de um sujeito que se (desconstrói em meio a um processo heterogêneo. Diante disso, a pergunta que norteia esse ensaio é: Como estudar esse processo de (desconstrução da subjetividade em redes sociais? A proposição que defendemos neste trabalho é a de que o sujeito adepto das redes sociais da internet encontra-se em um tempo-espaço propício a excitações que vão muito além das percepções idiossincráticas de cada indivíduo. Em função disso, propomos que estudar as (intersubjetividades nas RSI pode ser produtivo se relacionarmos as noções de caosmose (Guattari, self (Goffman e enunciação linguística (Benveniste. A conclusão a que chegamos é a de que o viés da enunciação linguística pode ser uma alternativa metodológica que auxilie na conexão entre uma concepção mais transversalista da subjetividade e a tese de que a interação social assemelha-se a uma encenação teatral e, por isso, pode tomar rumos diversos, de acordo com roteiros pré-estabelecidos e socialmente partilhados nos cenários digitais das RSI.

  20. Macrophages activate iNOS signaling in adventitial fibroblasts and contribute to adventitia fibrosis.

    Science.gov (United States)

    Zhang, Guannan; Li, Xiaodong; Sheng, Chengyu; Chen, Xiaohui; Chen, Yu; Zhu, Dingliang; Gao, Pingjin

    2016-12-30

    A large amount of NO is generated through the inducible nitric oxide synthase (iNOS) pathway from the vascular adventitia in various vascular diseases. However, it is currently not fully understood how the iNOS signaling pathway is activated. In the present study, this question was addressed in the context of adventitial cellular interactions. A rat model of acute hypertension in the contralateral carotid arteries was established through transverse aortic constriction (TAC) surgery. In this model, activated macrophages were found surrounded by a large quantity of iNOS-expressing adventitial fibroblasts (AFs), suggesting a possible causal relationship between macrophages and iNOS activation of the neighboring AFs. In an in vitro model, a macrophage-like cell line RAW 264.7 was first activated by LPS treatment. The supernatant was then harvested and applied to treat primary rat AFs. iNOS in AFs was activated robustly by the supernatant treatment but not by LPS itself. Treating AFs with interleukin-1β (IL-1β) also activated iNOS signaling, suggesting that the IL-1β pathway might be a possible mediator. As a consequence of the iNOS activation, total protein nitration and S-nitrosylation significantly increased in those AFs. Additionally, increased deposition of type I and type III collagens was observed in both in vitro and in vivo models. The collagen deposition was partially restored by an iNOS inhibitor, 1400 W. These findings highlight the importance of iNOS signaling during vascular inflammation, and advance our understanding of its activation through a cellular interaction perspective. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. iNOS inhibits hair regeneration in obese diabetic (ob/ob) mice.

    Science.gov (United States)

    Sasaki, Mari; Shinozaki, Shohei; Morinaga, Hironobu; Kaneki, Masao; Nishimura, Emi; Shimokado, Kentaro

    2018-07-02

    Previous studies have shown that androgenic alopecia is associated with metabolic syndrome and diabetes. However, the detailed mechanism whereby diabetes causes alopecia still remains unclear. We focused on the inflammatory response that is caused by diabetes or obesity, given that inflammation is a risk factor for hair loss. Inducible nitric oxide synthase (iNOS) is known to be upregulated under conditions of acute or chronic inflammation. To clarify the potential role of iNOS in diabetes-related alopecia, we generated obese diabetic iNOS-deficient (ob/ob; iNOS-KO mice). We observed that ob/ob; iNOS-KO mice were potentiated for the transition from telogen (rest phase) to anagen (growth phase) in the hair cycle compared with iNOS-proficient ob/ob mice. To determine the effect of nitric oxide (NO) on the hair cycle, we administered an iNOS inhibitor intraperitoneally (compound 1400 W, 10 mg/kg) or topically (10% aminoguanidine) in ob/ob mice. We observed that iNOS inhibitors promoted anagen transition in ob/ob mice. Next, we administered an NO donor (S-nitrosoglutathione, GSNO), to test whether NO has the telogen elongation effects. The NO donor was sufficient to induce telogen elongation in wild-type mice. Together, our data indicate that iNOS-derived NO plays a role in telogen elongation under the inflammatory conditions associated with diabetes in mice. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  2. Technical Specifications: Vogtle Electric Generating Plant, Unit Nos. 1 and 2 (Docket Nos. 50-424 and 50-425): Appendix ''A'' to License Nos. NPF-68 and NPF-79

    International Nuclear Information System (INIS)

    1989-02-01

    The Vogtle Electric Generating Plant, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear facility as set forth in Section 50.36 of 10 CFR 50 for the protection of the health and safety of the public

  3. Technical Specifications, Vogtle Electric Generating Plant, Unit Nos. 1 and 2 (Docket Nos. 50-424 and 50-425): Appendix ''A'' to License Nos. NPF-68 and NPF-81

    International Nuclear Information System (INIS)

    1989-03-01

    The Vogtle Electric Generating Plant, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear facility as set forth in Section 50.36 of 10 CFR 50 for the protection of the health and safety of the public

  4. Technical Specifications, South Texas Project, Unit Nos. 1 and 2 (Docket Nos. 50-498 and 50-499): Appendix ''A'' to License Nos. NPF-76 and NPF-80

    International Nuclear Information System (INIS)

    1989-03-01

    The South Texas Project, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public

  5. Technical specifications, South Texas Project, Unit Nos. 1 and 2 (Docket Nos. 50-498 and 50-499): Appendix ''A'' to License Nos. NPF-76 and NPF-78

    International Nuclear Information System (INIS)

    1989-01-01

    The South Texas Project, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public

  6. História e oralidade nos estudos comunicacionais

    Directory of Open Access Journals (Sweden)

    Juniele Rabêlo Almeida

    2016-05-01

    Full Text Available Concepções, métodos e formas do conhecimento histórico são expressos em diversos estudos na área de comunicação social. Buscamos analisar, na interface história e narrativa oral, aspectos da chamada mediação cultural, na qual a comunicação está para além da condição de canal. Acreditamos que os estudos comunicacionais não recaem, necessariamente, sobre especificidades técnicas, mas sobre a posição que a comunicação assume no campo histórico-cultural. Interações, expressas nos trabalhos de história oral, se configuram (e resultam em processos comunicacionais que indicam construções sócio históricas e diferentes referenciais de pertencimento. Palavras-chave: Estudos comunicacionais, História, Narrativas Orais.   Abstract: Conceptions, methods and historical knowledge forms are expressed in several studies in the area of social communication. We analyze, history and oral narrative interface, called aspects of cultural mediation, in which the communication is in addition to the channel condition. We believe that communication studies do not fall necessarily on technicalities, but on the position that the communication is in the historical-cultural field. Interactions, expressed in the works of oral history, are configured (and result in communication processes that indicate historical social constructions and different frames of belonging. Keywords: communication Studies, History, Oral Narratives.   Resumen: Conceptos, métodos y formas de conocimiento histórico se expresan en varios estudios en el área de la comunicación social. Analizamos, la historia y la interfaz de la narrativa oral, llamados aspectos de mediación cultural, en el que la comunicación es, además de la condición de canal. Creemos que los estudios de comunicación no caen necesariamente en técnicos, sino a la posición de que la comunicación es en el campo histórico-cultural. Interacciones, expresados en las obras de la historia oral, est

  7. NOS CO-OPS Water Level Data, High Low Tide Prediction

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has High Low Tide Predictions from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). The official Tide and Tidal Current...

  8. NOS CO-OPS Water Level Data, Tide Prediction, 60-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has High Low Tide Predictions from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). The official Tide and Tidal Current...

  9. NODC Standard Format NOS Coastal Wave Program (F182) Data (1979-1983) (NODC Accession 0014203)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data type was designed for analyzed wave data originating from the National Ocean Service (NOS) Coastal Wave Program. The data are organized into 3 record...

  10. NOS CO-OPS Water Level Data, Tide Prediction, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has High Low Tide Predictions from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). The official Tide and Tidal Current...

  11. Endogenous angiotensin II modulates nNOS expression in renovascular hypertension

    Directory of Open Access Journals (Sweden)

    T.M.C. Pereira

    2009-07-01

    Full Text Available Nitric oxide (NO influences renal blood flow mainly as a result of neuronal nitric oxide synthase (nNOS. Nevertheless, it is unclear how nNOS expression is modulated by endogenous angiotensin II, an inhibitor of NO function. We tested the hypothesis that the angiotensin II AT1 receptor and oxidative stress mediated by NADPH oxidase contribute to the modulation of renal nNOS expression in two-kidney, one-clip (2K1C hypertensive rats. Experiments were performed on male Wistar rats (150 to 170 g body weight divided into 2K1C (N = 19 and sham-operated (N = 19 groups. nNOS expression in kidneys of 2K1C hypertensive rats (N = 9 was compared by Western blotting to that of 2K1C rats treated with low doses of the AT1 antagonist losartan (10 mg·kg-1·day-1; N = 5 or the superoxide scavenger tempol (0.2 mmol·kg-1·day-1; N = 5, which still remain hypertensive. After 28 days, nNOS expression was significantly increased by 1.7-fold in the clipped kidneys of 2K1C rats and by 3-fold in the non-clipped kidneys of 2K1C rats compared with sham rats, but was normalized by losartan. With tempol treatment, nNOS expression increased 2-fold in the clipped kidneys and 1.4-fold in the non-clipped kidneys compared with sham rats. The changes in nNOS expression were not followed by changes in the enzyme activity, as measured indirectly by the cGMP method. In conclusion, AT1 receptors and oxidative stress seem to be primary stimuli for increased nNOS expression, but this up-regulation does not result in higher enzyme activity.

  12. Angiotensin II blockade causes acute renal failure in eNOS-deficient mice

    Directory of Open Access Journals (Sweden)

    Jürgen Schnermann

    2001-03-01

    Full Text Available Compared with wild-type mice, adult endothelial nitric oxide synthase (eNOS knockout mice (eight months of age have increased blood pressure (BP (126±9 mmHg vs. 100±4 mmHg, and an increased renal vascular resistance (155±16 vs. 65±4 mmHg.min/ml. Renal vascular resistance responses to i.v. administration of noradrenaline were markedly enhanced in eNOS knockout mice. Glomerular filtration rate (GFR of anaesthetised eNOS -/- mice was 324±57 µl/min gKW, significantly lower than the GFR of 761±126 µl/min.gKW in wild-type mice. AT1-receptor blockade with i.v. candesartan (1—1.5 mg/kg reduced arterial blood pressure and renal vascular resistance, and increased renal blood flow (RBF to about the same extent in wild-type and eNOS -/- mice. Candesartan did not alter GFR in wild-type mice (761±126 vs. 720±95 µl/min.gKW, but caused a marked decrease in GFR in eNOS -/- mice (324.5±75.2 vs. 77±18 µl/min.gKW. A similar reduction in GFR of eNOS deficient mice was also caused by angiotensin-converting enzyme (ACE inhibition. Afferent arteriolar granularity, a measure of renal renin expression, was found to be reduced in eNOS -/- compared with wild-type mice. In chronically eNOS-deficient mice, angiotensin II (Ang II is critical for maintaining glomerular filtration pressure and GFR, presumably through its effect on efferent arteriolar tone.

  13. A central role of eNOS in the protective effect of wine against metabolic syndrome.

    Science.gov (United States)

    Leighton, Federico; Miranda-Rottmann, Soledad; Urquiaga, Inés

    2006-01-01

    The positive health effects derived from moderate wine consumption are pleiotropic. They appear as improvements in cardiovascular risk factors such as plasma lipids, haemostatic mechanisms, endothelial function and antioxidant defences. The active principles would be ethanol and mainly polyphenols. Results from our and other laboratories support the unifying hypothesis that the improvements in risk factors after red wine consumption are mediated by endothelial nitric oxide synthase (eNOS). Many genes are involved, but the participation of eNOS would be a constant feature. The metabolic syndrome is a cluster of metabolic risk factors associated with high risk of cardiovascular disease (CVD). The National Cholesterol Education Programmmes Adult Treatment Panel III (NCEPATP III) clinical definition of the metabolic syndrome requires the presence of at least three risk factors, from among abdominal obesity, high plasma triacylglycerols, low plasma HDL, high blood pressure and high fasting plasma glucose. The molecular mechanisms responsible for the metabolic syndrome are not known. Since metabolic syndrome apparently affects 10-30% of the population in the world, research on its pathogenesis and control is needed. The recent finding that eNOS knockout mice present a cluster of cardiovascular risk factors comparable to those of the metabolic syndrome suggests that defects in eNOS function may cause human metabolic syndrome. These mice are hypertensive, insulin resistant and dyslipidemic. Further support for a pathogenic role of eNOS comes from the finding in humans that eNOS polymorphisms associate with insulin resistance and diabetes, with hypertension, with inflammatory and oxidative stress markers and with albuminuria. So, the data sustain the hypothesis that eNOS enhancement should reduce metabolic syndrome incidence and its consequences. Therefore red wine, since it enhances eNOS function, should be considered as a potential tool for the control of metabolic

  14. Permanente homoseksuele verhoudings van liefde en trou

    Directory of Open Access Journals (Sweden)

    J Potgieter

    2006-09-01

    Full Text Available In this article, the argument is made that homosexual relationships of love and commitment was known by the writers of the Bible. Though definitions like �gay� or �homosexuality� was not known, sexual identity was known. According to the anthropology of the Mediterranean people, somebody�s identity was found in the way he or she lived: �If I have a homosexual relationship, then my identity was homosexual�. This article shows that permanent homosexual relationships of love and commitment were known among the Greek philosophers. People like Plato, Aristotle and Pausanius had permanent homosexual partners. Even Paul knew about permanent homosexual relationships of love and commitment. Sufficient evidence has been found in cities like Rome, Corinth and Ephesus on the existence of such relationships.

  15. Forsegling af okklusal dentincaries i permanente molarer

    DEFF Research Database (Denmark)

    Qvist, Vibeke; Borum, Mette Kit; Dynes Møller, Kirsten

    2017-01-01

    Der findes ingen eksakte tal for forekomsten af fødevareallergi i den danske befolkning. Den kumulerede forekomst af fødevareallergi hos børn i de første tre leveår skønnes at være på 7-8 %, hvoraf hovedparten vokser sig fra det. Punktprævalensen af diagnosticeret fødevareallergi hos voksne er 3 ...

  16. LA ENTREVISTA, UN DIÁLOGO PERMANENTE.

    Directory of Open Access Journals (Sweden)

    Yolanda Puyana V.

    2012-04-01

    Full Text Available El objeto del presente artículo es mostrar tres escenarios sobre la entrevista que son útiles para la docencia y acción profesional de trabajo social. Se busca profundizar sobre la entrevista desde diferentes perspectivas teóricas y metodológicas. En primer término, se tratará el enfoque humanista de Karl Rogers y la mirada etnográfica de Roberta Greene. En segundo término, se esboza el aporte de Sigmud Freud. Finalmente se señala la contribución a la entrevista del modelo sistémico de la Escuela de Terapia Familiar de Milán.

  17. Activation of Endothelial Nitric Oxide (eNOS Occurs through Different Membrane Domains in Endothelial Cells.

    Directory of Open Access Journals (Sweden)

    Jason Tran

    Full Text Available Endothelial cells respond to a large range of stimuli including circulating lipoproteins, growth factors and changes in haemodynamic mechanical forces to regulate the activity of endothelial nitric oxide synthase (eNOS and maintain blood pressure. While many signalling pathways have been mapped, the identities of membrane domains through which these signals are transmitted are less well characterized. Here, we manipulated bovine aortic endothelial cells (BAEC with cholesterol and the oxysterol 7-ketocholesterol (7KC. Using a range of microscopy techniques including confocal, 2-photon, super-resolution and electron microscopy, we found that sterol enrichment had differential effects on eNOS and caveolin-1 (Cav1 colocalisation, membrane order of the plasma membrane, caveolae numbers and Cav1 clustering. We found a correlation between cholesterol-induced condensation of the plasma membrane and enhanced high density lipoprotein (HDL-induced eNOS activity and phosphorylation suggesting that cholesterol domains, but not individual caveolae, mediate HDL stimulation of eNOS. Vascular endothelial growth factor (VEGF-induced and shear stress-induced eNOS activity was relatively independent of membrane order and may be predominantly controlled by the number of caveolae on the cell surface. Taken together, our data suggest that signals that activate and phosphorylate eNOS are transmitted through distinct membrane domains in endothelial cells.

  18. Technical specifications, Braidwood Station, Unit Nos. 1 and 2 (Docket Nos. STN 50-456 and STN 50-457): Appendix ''A'' to License No. NPF-70

    International Nuclear Information System (INIS)

    1987-05-01

    The Braidwood Station, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public. 18 figs., 55 tabs

  19. Conformance to Regulatory Guide 1.97, Shearon Harris Nuclear Power Plant, Unit Nos. 1 and 2 (Docket Nos. 50-400 and 50-401)

    International Nuclear Information System (INIS)

    Stoffel, J.W.

    1985-09-01

    This EG and G Idaho, Inc. report reviews the submittals for Regulatory Guide 1.97, Revision 3, for Unit Nos. 1 and 2 of the Shearon Harris Nuclear Power Plant and identifies areas of nonconformance to the regulatory guide. Exceptions to Regulatory Guide 1.97 are evaluated and those areas where sufficient basis for acceptability is not provided are identified. 7 refs

  20. Conformance to Regulatory Guide 1.97, Perry Nuclear Power Plant, Unit Nos. 1 and 2 (Docket Nos. 50-440 and 50-441)

    International Nuclear Information System (INIS)

    Udy, A.C.

    1985-03-01

    This EG and G Idaho, Inc., report provides a review of the submittals for Regulatory Guide 1.97, Revision 2, for the Perry Nuclear Power Plant, Unit Nos. 1 and 2. Any exception to the guidelines of Regulatory Guide 1.97 are evaluated

  1. Conformance to Regulatory Guide 1.97 Slurry Power Station, Unit Nos. 1 and 2 (Docket Nos. 50-280 and 50-281)

    International Nuclear Information System (INIS)

    Stoffel, J.W.

    1985-09-01

    This EG and G Idaho, Inc., report reviews the submittals for Regulatory Guide 1.97, Revision 3, for Unit Nos. 1 and 2 of the Surry Power Station and identifies areas of nonconformance to the regulatory guide. Exceptions to Regulatory Guide 1.97 are evaluated and those areas where sufficient basis for acceptability is not provided are identified

  2. Overview on the permanent magnets technology of rare earth based on Nd-Fe-B; Panorama general sobre tecnologia de imanes permanentes de tierras raras a base de Nd-Fe-B

    Energy Technology Data Exchange (ETDEWEB)

    Rosales Vazquez, Maria Ines [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1990-12-31

    In this paper the technological development in the area of permanent magnetic materials, is shown, from the 1930`s when the first aluminum-nickel-cobalt (Al-Ni-Co) magnets appeared. As a result of the continuous worldwide research in this field, it was made known, during the 1980`s decade of a new type of magnets based on Neodymium (Nd). In accordance with the outstanding magnetic properties of these magnets, at the Instituto de Investigaciones Electricas (IIE), their development was initiated, focussed on the stages and parameters definition of their manufacturing process. Up to now, the research has been oriented to the preparation of magnets of the isotropic agglutinated type and the manufacturing process encompasses the following stages: a) Alloy preparation; b) Microcrystals obtainment; c) Magnet preparation. The preliminary results that have been obtained in the magnetic characterization show that the quality of the prepared magnets is comparable to the quality of the imported magnets and/or to the ones other research groups report. [Espanol] En este trabajo se muestra el desarrollo tecnologico del area de materiales magneticos permanentes a partir de los anos treinta en que surgieron los primeros imanes de aluminio-niquel-cobalto (Al-Ni-Co). Como resultado de la constante investigacion a nivel mundial en ese campo, durante el decenio de los ochenta se informo en torno a un nuevo tipo de imanes a base de neodimio (Nd). Atendiendo a las propiedades magneticas sobresalientes de estos imanes, en el Instituto de Investigaciones Electricas (IIE), se inicio el desarrollo de los mismos, enfocandolo a la definicion de las etapas y parametros del proceso de fabricacion. Hasta ahora, la investigacion se ha orientado a la preparacion de imanes de tipo isotropico aglutinado y el proceso de fabricacion comprende las etapas: a) preparacion de la aleacion; b) obtencion de microcristales, y c) preparacion de los imanes. Los resultados preliminares que se han obtenido en la

  3. Conflitos no uso da terra em Áreas de Preservação Permanente em um polo de produção de biodiesel no Estado do Pará

    Directory of Open Access Journals (Sweden)

    Arlete Silva de Almeida

    2014-07-01

    Full Text Available As Áreas de Preservação Permanente (APPs desempenham um papel fundamental na manutenção dos principais fatores que regulam os processos hidrológicos e de conservação biológica. Na Amazônia, as APPs vêm sendo ocupadas com atividades econômicas de alto impacto ambiental que levam à supressão de vegetação, desrespeitando o regime legal desse tipo de área protegida. Este artigo analisa os conflitos de uso da terra dentro das áreas destinadas à preservação e propõe uma delimitação dessas áreas de acordo com o Código Florestal Brasileiro de 2012, no municipio de Moju, um dos mais importantes polos de produção de biodiesel do estado do Pará. A pesquisa utilizou imagem multiespectral de alta resolução do satélite RapidEye de 2010 para uma classificação supervisionada que determinou oito classes de cobertura e uso da terra, com especial atenção para a floresta, o cultivo agrícola e cultivo de óleo de palma (Elaeis guineensis. As terras alteradas do município perfazem 30,29% do total, sendo que 17,07% estão ocupadas pela pecuária. Somente 5,2% do território de Moju é legalmente definido como APP. Destas áreas, 29,3% se encontram em uso conflituoso, onde predomina a pastagem, presente em 15,6% das APPs do município. O cultivo de palma corresponde a apenas 0,63% da área da APP e a 2,17% do município. A aplicação das novas regras de recomposição de APPs pelo novo Código Florestal Brasileiro irá resultar em perda de 60,69% de área recuperada em APPs neste município.

  4. Overview on the permanent magnets technology of rare earth based on Nd-Fe-B; Panorama general sobre tecnologia de imanes permanentes de tierras raras a base de Nd-Fe-B

    Energy Technology Data Exchange (ETDEWEB)

    Rosales Vazquez, Maria Ines [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1991-12-31

    In this paper the technological development in the area of permanent magnetic materials, is shown, from the 1930`s when the first aluminum-nickel-cobalt (Al-Ni-Co) magnets appeared. As a result of the continuous worldwide research in this field, it was made known, during the 1980`s decade of a new type of magnets based on Neodymium (Nd). In accordance with the outstanding magnetic properties of these magnets, at the Instituto de Investigaciones Electricas (IIE), their development was initiated, focussed on the stages and parameters definition of their manufacturing process. Up to now, the research has been oriented to the preparation of magnets of the isotropic agglutinated type and the manufacturing process encompasses the following stages: a) Alloy preparation; b) Microcrystals obtainment; c) Magnet preparation. The preliminary results that have been obtained in the magnetic characterization show that the quality of the prepared magnets is comparable to the quality of the imported magnets and/or to the ones other research groups report. [Espanol] En este trabajo se muestra el desarrollo tecnologico del area de materiales magneticos permanentes a partir de los anos treinta en que surgieron los primeros imanes de aluminio-niquel-cobalto (Al-Ni-Co). Como resultado de la constante investigacion a nivel mundial en ese campo, durante el decenio de los ochenta se informo en torno a un nuevo tipo de imanes a base de neodimio (Nd). Atendiendo a las propiedades magneticas sobresalientes de estos imanes, en el Instituto de Investigaciones Electricas (IIE), se inicio el desarrollo de los mismos, enfocandolo a la definicion de las etapas y parametros del proceso de fabricacion. Hasta ahora, la investigacion se ha orientado a la preparacion de imanes de tipo isotropico aglutinado y el proceso de fabricacion comprende las etapas: a) preparacion de la aleacion; b) obtencion de microcristales, y c) preparacion de los imanes. Los resultados preliminares que se han obtenido en la

  5. Avaliação quantitativa do efeito do jato de bicarbonato de sódio no esmalte de dentes permanentes jovens Quantitative analysis of the effect of sodium bicarbonate on the enamel surface of young permanent teeth

    Directory of Open Access Journals (Sweden)

    Sara Nader MARTA

    1999-01-01

    Full Text Available Avaliou-se clinicamente o efeito do jato de bicarbonato de sódio sob pressão, empregado na profilaxia da superfície de esmalte sadio de dentes permanentes jovens. Trabalhou-se com réplicas positivas, o que permitiu a análise antes e após a realização de tal procedimento. Foram feitas sessenta moldagens da superfície vestibular de incisivos centrais superiores, as quais sofreram um preparo para a análise quantitativa da rugosidade das superfícies de esmalte. A análise quantitativa foi efetuada utilizando-se o programa para computador Diracom-3, que mensura as sombras e penumbras das imagens dos espécimes. Estabeleceram-se três grupos experimentais com vinte crianças que nunca haviam sido submetidas à profilaxia com Profident, as quais foram moldadas em três momentos. Antes do procedimento ou controle (Grupo 1; imediatamente após (Grupo 2; e um mês após o tratamento (Grupo 3. A análise quantitativa dos dados mostrou não haver diferença estatisticamente significante entre os grupos analisados.The effect of sodium bicarbonate under pressure used in the prophylaxis of the healthful enamel surface of young permanent teeth was clinically evaluated. Positive reproductions were used, which permitted the analysis before and after the realization of such procedure. The moldings of the vestibular surface of central superior incisives made totalized sixty, which went trough a preparation for the quantitative rugosity analysis of the enamel surfaces. The computer program DIRACOM - 3, that measures the shades and half - shadows of the sample images was used for quantitative analysis for which the scanning electron microscopy was employed. Three experimental groups with twenty children each, who had never been submitted to that technique of prophylaxis were established and molds taken in three moments: Group 1 - before the procedure or control ; Group 2 - immediately after and Group 3 - one month after the treatment ( subgroup 2c . The

  6. ANÁLISE DA CORRELAÇÃO ENTRE AS VARIÁVEIS DE DENSIFICAÇÃO DO COMPACTADOR GIRATÓRIO SUPERPAVE E A RESISTÊNCIA À DEFORMAÇÃO PERMANENTE EM MISTURAS ASFÁLTICAS CONVENCIONAIS E COM UTILIZAÇÃO DE RESÍDUOS

    Directory of Open Access Journals (Sweden)

    Felipe Coutinho Onofre

    2011-09-01

    Full Text Available

    Quando se comparam as metodologias de dosagem Superpave e Marshall de misturas asfálticas, uma das vantagens da primeira é a obtenção do gráfico de compactação. Tem sido verificado para misturas densas e contínuas do tipo Concreto Asfáltico (CA que determinadas áreas observadas nesse gráfico podem diferenciar estas misturas quanto à trabalhabilidade e à resistência à deformação permanente. No presente estudo, os parâmetros Compaction Densification Index (CDI e Traffic Densification Index (TDI foram utilizados como indicadores da compactabilidade. Desenvolveu-se um estudo de correlação entre estas variáveis e a resistência à deformação permanente de misturas asfálticas. Foram avaliadas três misturas asfálticas contendo: (i apenas agregados graníticos, (ii 50% de agregados graníticos e 50% de escória de aciaria e (iii 50% de agregados graníticos e 50% de Resíduo de Construção e Demolição (RCD. As variáveis escolhidas para determinação da resistência à deformação permanente foram o ensaio uniaxial de carga repetida (amostras compactadas para dois percentuais de Volume de vazios e o ensaio com um simulador de tráfego do tipo LCPC. Foi utilizado também o Processamento Digital de Imagens (PDI para a determinação da esfericidade dos agregados estudados, propriedade que influencia na resistência à deformação permanente. Os resultados indicam que as variáveis CDI e TDI podem ser usadas como parâmetros de estudo para prever a resistência à deformação permanente, mesmo para misturas com utilização de resíduos. A caracterização pela técnica do PDI mostrou que o agregado de origem granítica possui uma forma menos próxima a uma esfera em relação aos res

  7. The protein inhibitor of nNOS (PIN/DLC1/LC8) binding does not inhibit the NADPH-dependent heme reduction in nNOS, a key step in NO synthesis

    International Nuclear Information System (INIS)

    Parhad, Swapnil S.; Jaiswal, Deepa; Ray, Krishanu; Mazumdar, Shyamalava

    2016-01-01

    The neuronal nitric oxide synthase (nNOS) is an essential enzyme involved in the synthesis of nitric oxide (NO), a potent neurotransmitter. Although previous studies have indicated that the dynein light chain 1 (DLC1) binding to nNOS could inhibit the NO synthesis, the claim is challenged by contradicting reports. Thus, the mechanism of nNOS regulation remained unclear. nNOS has a heme-bearing, Cytochrome P450 core, and the functional enzyme is a dimer. The electron flow from NADPH to Flavin, and finally to the heme of the paired nNOS subunit within a dimer, is facilitated upon calmodulin (CaM) binding. Here, we show that DLC1 binding to nNOS-CaM complex does not affect the electron transport from the reductase to the oxygenase domain. Therefore, it cannot inhibit the rate of NADPH-dependent heme reduction in nNOS, which results in L-Arginine oxidation. Also, the NO release activity does not decrease with increasing DLC1 concentration in the reaction mix, which further confirmed that DLC1 does not inhibit nNOS activity. These findings suggest that the DLC1 binding may have other implications for the nNOS function in the cell. - Highlights: • The effect of interaction of nNOS with DLC1 has been debatable with contradicting reports in literature. • Purified DLC1 has no effect on electron transport between reductase and oxygenase domain of purified nNOS-CaM. • The NO release activity of nNOS was not altered by DLC1, supporting that DLC1 does not inhibit the enzyme. • These findings suggest that the DLC1 binding may have other implications for the nNOS function in the cell.

  8. The protein inhibitor of nNOS (PIN/DLC1/LC8) binding does not inhibit the NADPH-dependent heme reduction in nNOS, a key step in NO synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Parhad, Swapnil S. [Tata Institute of Fundamental Research (TIFR), Homi Bhabha Road, Mumbai 400 005 (India); Jaiswal, Deepa [Tata Institute of Fundamental Research (TIFR), Homi Bhabha Road, Mumbai 400 005 (India); TIFR Centre for Interdisciplinary Sciences, 21 Brundavan Colony, Narsingi, Hyderabad 500075 (India); Ray, Krishanu, E-mail: krishanu@tifr.res.in [Tata Institute of Fundamental Research (TIFR), Homi Bhabha Road, Mumbai 400 005 (India); Mazumdar, Shyamalava, E-mail: shyamal@tifr.res.in [Tata Institute of Fundamental Research (TIFR), Homi Bhabha Road, Mumbai 400 005 (India)

    2016-03-25

    The neuronal nitric oxide synthase (nNOS) is an essential enzyme involved in the synthesis of nitric oxide (NO), a potent neurotransmitter. Although previous studies have indicated that the dynein light chain 1 (DLC1) binding to nNOS could inhibit the NO synthesis, the claim is challenged by contradicting reports. Thus, the mechanism of nNOS regulation remained unclear. nNOS has a heme-bearing, Cytochrome P450 core, and the functional enzyme is a dimer. The electron flow from NADPH to Flavin, and finally to the heme of the paired nNOS subunit within a dimer, is facilitated upon calmodulin (CaM) binding. Here, we show that DLC1 binding to nNOS-CaM complex does not affect the electron transport from the reductase to the oxygenase domain. Therefore, it cannot inhibit the rate of NADPH-dependent heme reduction in nNOS, which results in L-Arginine oxidation. Also, the NO release activity does not decrease with increasing DLC1 concentration in the reaction mix, which further confirmed that DLC1 does not inhibit nNOS activity. These findings suggest that the DLC1 binding may have other implications for the nNOS function in the cell. - Highlights: • The effect of interaction of nNOS with DLC1 has been debatable with contradicting reports in literature. • Purified DLC1 has no effect on electron transport between reductase and oxygenase domain of purified nNOS-CaM. • The NO release activity of nNOS was not altered by DLC1, supporting that DLC1 does not inhibit the enzyme. • These findings suggest that the DLC1 binding may have other implications for the nNOS function in the cell.

  9. Seasonal maturation of Glypthelmins vitellinophilum (Trematoda: Digenea in Lysapsus limellus (Anura: Pseudidae from an Argentinian subtropical permanent pond Maturação sazonal de Glypthelmins vitellinophilum (Trematoda: Digenea em Lysapsus limellus (Anura: Pseudidae em uma lagoa permanente subtropical da Argentina

    Directory of Open Access Journals (Sweden)

    M. I. Hamann

    2006-02-01

    Full Text Available From December 1995 to November 2000, the seasonal maturation of Glypthelmins vitellinophilum Dobbin, 1958, in its definitive host, the frog Lysapsus limellus Cope, 1862, was studied in a subtropical permanent pond in northeastern Argentina. The objectives of this study were: 1 to determine the infrapopulation dynamics of the parasite, analyzing the seasonal maturation cycle throughout the years; and 2 to examine the relationship between the intensity of trematode infection in different developmental stages (recruitment, growth and maturation and the host's body length. Of a total of 1,400 frogs examined over 60 months (5 years, 38% were found to be infected with G. vitellinophilum, and the intensity of infection was 1-15 trematodes per frog. Specimens of G. vitellinophilum were present in L. limellus throughout the years, but did not show a pronounced seasonal maturation cycle. Possible reasons for these findings are discussed with reference to climatic fluctuations and biotic factors. The infective period of the parasite (stage I occurred in summer, autumn and spring, coinciding with the time each frog cohort appeared. These infections were found principally in small body sizes (classes 1 and 2 of L. limellus. Juvenile and nongravid specimens of worms (stage II and III were found in frogs of different body sizes throughout the period of investigation. Gravid specimens of the parasite (stage IV were generally recorded in autumn, winter and spring, mainly in the bodies of larger frogs. The body length of Trematodes in stages I and IV was significantly and positively correlated with that of the frogs.De dezembro de 1995 a novembro de 2000, a maturação sazonal de Glypthelmins vitellinophilum Dobbin, 1958, em seu hospedeiro definitivo, a rã Lysapsus limellus Cope, 1862, foi estudada em uma lagoa permanente subtropical no nordeste da Argentina. Os objetivos deste estudo foram: 1 determinar a dinâmica de infrapopulação do parasita, analisando o

  10. A vivência no processo formativo do projeto Educanvisa: relato de uma experiência de formação permanente | The Experience in Process Formation Project Educanvisa: Report of a Permanent Training Experience

    Directory of Open Access Journals (Sweden)

    Ivanilde Alves Borba Rigo

    2015-02-01

    Full Text Available Este relato tem como objetivo apresentar a vivência no processo formativo dos educadores no Projeto Educanvisa, desenvolvido no Município de Lucas do Rio Verde/MT no ano de 2012, tendo como público os educadores da rede Municipal de Ensino das unidades de Educação Infantil e da Educação Básica. O relato foi focado na educação permanente de educadores, com a finalidade de capacitá-los para que se tornassem multiplicadores e mediadores do assunto em salas de aula. Neste processo de educação permanente, os educadores foram submetidos a palestras orientativas com profissionais da saúde como: nutricionista, farmacêutico, enfermeiros, médico bioquímico e representante da vigilância sanitária. Após adquirido o conhecimento, os educadores tornaram-se multiplicadores e mediadores nas escolas, fazendo o repasse para outros profissionais da educação, os quais tiveram a responsabilidade de efetivar o conhecimento nas salas de aula. O repasses aos educandos se deu por meio de palestras com profissionais da saúde, atividades didático-pedagógicas sobre temas como: A Saúde e a Promoção da Saúde; A Vigilância Sanitária; Os Medicamentos/Alimentos; A Propaganda de Medicamentos e de Alimentos e orientações a comunidade escolar. Nesta perspectiva teve-se, no ano de 2012, um envolvimento de 7.601 alunos, 407 educadores, 15 instituições de ensino mais a comunidade escolar, sendo estes contribuintes de uma reflexão sobre as práticas indevidas do uso de medicamentos e produtos sujeitos à vigilância sanitária. Neste contexto foi possível observar o aprendizado de forma integrada entres os vários atores sociais envolvidos no processo, o que possibilitou a construção de novos valores e experiências no coletivo, aspectos estes que só foram possíveis devido à formação e à multiplicação de conteúdos e experiências integralizadas na prática coletiva

  11. Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway

    Energy Technology Data Exchange (ETDEWEB)

    Nagane, Masaki; Yasui, Hironobu; Sakai, Yuri; Yamamori, Tohru [Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818 (Japan); Niwa, Koichi [Laboratory of Biochemistry, Department of Food and Cosmetic Science, Faculty of Bioindustry, Tokyo University of Agriculture, Abashiri 099-2493 (Japan); Hattori, Yuichi [Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194 (Japan); Kondo, Takashi [Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194 (Japan); Inanami, Osamu, E-mail: inanami@vetmed.hokudai.ac.jp [Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818 (Japan)

    2015-01-02

    Highlights: • eNOS activity is increased in BAECs exposed to X-rays. • ATM is involved in this increased eNOS activity. • HSP90 modulates the radiation-induced activation of ATM and eNOS. - Abstract: In this study, the involvement of ataxia telangiectasia mutated (ATM) kinase and heat shock protein 90 (HSP90) in endothelial nitric oxide synthase (eNOS) activation was investigated in X-irradiated bovine aortic endothelial cells. The activity of nitric oxide synthase (NOS) and the phosphorylation of serine 1179 of eNOS (eNOS-Ser1179) were significantly increased in irradiated cells. The radiation-induced increases in NOS activity and eNOS-Ser1179 phosphorylation levels were significantly reduced by treatment with either an ATM inhibitor (Ku-60019) or an HSP90 inhibitor (geldanamycin). Geldanamycin was furthermore found to suppress the radiation-induced phosphorylation of ATM-Ser1181. Our results indicate that the radiation-induced eNOS activation in bovine aortic endothelial cells is regulated by ATM and HSP90.

  12. Outcome after BCG treatment for urinary bladder cancer may be influenced by polymorphisms in the NOS2 and NOS3 genes.

    Science.gov (United States)

    Ryk, Charlotta; Koskela, Lotta Renström; Thiel, Tomas; Wiklund, N Peter; Steineck, Gunnar; Schumacher, Martin C; de Verdier, Petra J

    2015-12-01

    Bacillus Calmette-Guérin (BCG)-treatment is an established treatment for bladder cancer, but its mechanisms of action are not fully understood. High-risk non-muscle invasive bladder-cancer (NMIBC)-patients failing to respond to BCG-treatment have worse prognosis than those undergoing immediate radical cystectomy and identification of patients at risk for BCG-failure is of high priority. Several studies indicate a role for nitric oxide (NO) in the cytotoxic effect that BCG exerts on bladder cancer cells. In this study we investigated whether NO-synthase (NOS)-gene polymorphisms, NOS2-promoter microsatellite (CCTTT)n, and the NOS3-polymorphisms-786T>C (rs2070744) and Glu298Asp (rs1799983), can serve as possible molecular markers for outcome after BCG-treatment for NMIBC. All NMIBC-patients from a well-characterized population based cohort were analyzed (n=88). Polymorphism data were combined with information from 15-years of clinical follow-up. The effect of BCG-treatment on cancer-specific death (CSD), recurrence and progression in patients with varying NOS-genotypes were studied using Cox proportional hazard-models and log rank tests. BCG-treatment resulted in significantly better survival in patients without (Log rank: p=0.006; HR: 0.12, p=0.048), but not in patients with a long version ((CCTTT)n ≧13 repeats) of the NOS2-promoter microsatellite. The NOS3-rs2070744(TT) and rs1799983(GG)-genotypes showed decreased risk for CSD (Log rank(TT): p=0.001; Log rank(GG): p=0.010, HR(GG): 0.16, p=0.030) and progression (Log rank(TT): p<0.001, HR(TT): 0.05, p=0.005; Log rank(GG): p<0.001, HR(GG): 0.10, p=0.003) after BCG-therapy compared to the other genotypes. There was also a reduction in recurrence in BCG-treated patients that was mostly genotype independent. Analysis of combined genotypes identified a subgroup of 30% of the BCG-treated patients that did not benefit from BCG-treatment. Our results suggest that the investigated polymorphisms influence patient response

  13. iNOS-dependent increase in colonic mucus thickness in DSS-colitic rats.

    Directory of Open Access Journals (Sweden)

    Olof Schreiber

    Full Text Available AIM: To investigate colonic mucus thickness in vivo in health and during experimental inflammatory bowel disease. METHODS: Colitis was induced with 5% DSS in drinking water for 8 days prior to experiment, when the descending colonic mucosa of anesthetized rats was studied using intravital microscopy. Mucus thickness was measured with micropipettes attached to a micromanipulator. To assess the contributions of NOS and prostaglandins in the regulation of colonic mucus thickness, the non-selective NOS-inhibitor L-NNA (10 mg/kg bolus followed by 3 mg/kg/h, the selective iNOS-inhibitor L-NIL (10 mg/kg bolus followed by 3 mg/kg/h and the non-selective COX-inhibitor diclofenac (5 mg/kg were administered intravenously prior to experiment. To further investigate the role of iNOS in the regulation of colonic mucus thickness, iNOS -/- mice were used. RESULTS: Colitic rats had a thicker firmly adherent mucus layer following 8 days of DSS treatment than untreated rats (88±2 µm vs 76±1 µm. During induction of colitis, the thickness of the colonic mucus layer initially decreased but was from day 3 significantly thicker than in untreated rats. Diclofenac reduced the mucus thickness similarly in colitic and untreated rats (-16±5 µm vs -14±2 µm. While L-NNA had no effect on colonic mucus thickness in DSS or untreated controls (+3±2 µm vs +3±1 µm, L-NIL reduced the mucus thickness significantly more in colitic rats than in controls (-33±4 µm vs -10±3 µm. The importance of iNOS in regulating the colonic mucus thickness was confirmed in iNOS-/- mice, which had thinner colonic mucus than wild-type mice (35±3 µm vs 50±2 µm, respectively. Furthermore, immunohistochemistry revealed increased levels of iNOS in the colonic surface epithelium following DSS treatment. CONCLUSION: Both prostaglandins and nitric oxide regulate basal colonic mucus thickness. During onset of colitis, the thickness of the mucus layer is initially reduced followed by an iNOS

  14. Design and preliminary results of the IMA plasma focus experiment

    Energy Technology Data Exchange (ETDEWEB)

    Soliman, H M; Masoud, M M [Arab Republic of Egypt, Atomic Energy Authority Plasma physics and Nuclear Fusion department, Cairo (Egypt)

    1994-12-31

    The present paper describes the design, operation and characteristics of aton 1MA plasma focus device, which built in egypt at the plasma physics department, N.R.C., atomic energy authority. The main parts of the system are: the coaxial electrodes of mather type, the expansion chamber, the condenser bank of 75 kJ stored energy, the pressurized spark gap switches and Blumlein trigger system. Measurement of the breakdown voltage between plasma focus electrodes and discharge current, using half of the condenser bank, showed that, for U{sub c} h = 32 kV, the discharge current was 0.5 Ma. In the discharge current and voltage traces a sharp drop in discharge current correspondingly to a sudden rise in voltage have been observed, which characterize the focus regime. Time structure of the x-ray emission measurements have been performed by means of scintillation detectors. by using a hydrogen gas the results showed that, the x-ray intensity is increased with increasing the hydrogen gas pressure. plasma sheath current density, J-Z distribution in axial direction during the acceleration phase of the discharge is studied, using a miniature Rogovsky coil. The results cleared that J{sub z} is increased with the axial distance from breech to muzzle at different hydrogen gas pressures. 12 figs.

  15. ProxImaL: efficient image optimization using proximal algorithms

    KAUST Repository

    Heide, Felix; Diamond, Steven; Nieß ner, Matthias; Ragan-Kelley, Jonathan; Heidrich, Wolfgang; Wetzstein, Gordon

    2016-01-01

    domain-specific language and compiler for image optimization problems that makes it easy to experiment with different problem formulations and algorithm choices. The language uses proximal operators as the fundamental building blocks of a variety

  16. Role matky očima prvorodiček

    OpenAIRE

    VOSÁTKOVÁ, Kristýna

    2017-01-01

    The bachelor thesis deals with the issue Mother's role from the perspective of primiparous mothers. The work aims to find out how the role of mother is perceived by the primaries themselves, what is part of this role and what is not part of it. At the same time, the work focuses on fathers and their duties in relation to the child, and the distinction of original ideas from the reality of the mothers of the firstborn. In order to attain the goal of the work, qualitative research was used in t...

  17. Analysis of impurities in semiconductor by IMA (SIMS)

    International Nuclear Information System (INIS)

    Komori, Junko; Masuko, Yoji; Koyama, Hiroshi

    1988-01-01

    The report outlines the measuring mechanism of SIMS and its applications in the field of semiconductor production. SIMS is the only equipment currently available for micrometer-order analysis and ppb-level impurities detection required for evaluation of semiconductors. In SIMS, sputtering of the sample surface is performed with primary ions and the secondary ions released from the sample are analyzed to identify the atomic species existing in the surface. The sputtering process and ionization process are outlined in the report, though the details of sputtering has not been fully clarified yet. In actual observation, some problems may be caused due to interfering ions and residual ions. In general, various ions including multi-valent ions, cluster ions, molecular ions, hydrogenated/oxygenated ions and hydrocarbon ions are produced in addition to monovalent ions to interfere the atoms under analysis. Interference by these ions can cause serious problems in carrying out depth profile analysis as well as observation of mass spectra. Major applications of SIMS in the field of semiconductor production include the evaluation of silicon surface, light elements, insulating materials and semiconductor devices. Some requirements to be met by further studies are also listed. (N.K.)

  18. Design and preliminary results of the IMA plasma focus experiment

    International Nuclear Information System (INIS)

    Soliman, H.M.; Masoud, M.M.

    1993-01-01

    The present paper describes the design, operation and characteristics of aton 1MA plasma focus device, which built in egypt at the plasma physics department, N.R.C., atomic energy authority. The main parts of the system are: the coaxial electrodes of mather type, the expansion chamber, the condenser bank of 75 kJ stored energy, the pressurized spark gap switches and Blumlein trigger system. Measurement of the breakdown voltage between plasma focus electrodes and discharge current, using half of the condenser bank, showed that, for U c h = 32 kV, the discharge current was 0.5 Ma. In the discharge current and voltage traces a sharp drop in discharge current correspondingly to a sudden rise in voltage have been observed, which characterize the focus regime. Time structure of the x-ray emission measurements have been performed by means of scintillation detectors. by using a hydrogen gas the results showed that, the x-ray intensity is increased with increasing the hydrogen gas pressure. plasma sheath current density, J-Z distribution in axial direction during the acceleration phase of the discharge is studied, using a miniature Rogovsky coil. The results cleared that J z is increased with the axial distance from breech to muzzle at different hydrogen gas pressures. 12 figs

  19. Teist korda kodus kodus käimas / Sven Karja

    Index Scriptorium Estoniae

    Karja, Sven, 1968-

    1999-01-01

    Harold Pinteri "Kojutulek" Tallinna Linnateatris, lavastaja Andres Noormets, kunstnik Aime Unt, osades Ago Roo, Marko Matvere, Andres Raag, Allan Noormets, Jaan Tätte, Triinu Meriste. Esietendus 24. märtsil

  20. Intrigeeriv idee paneb mootori käima / Signe Sillasoo

    Index Scriptorium Estoniae

    Sillasoo, Signe

    2011-01-01

    Salto Arhitektuuribüroos (Maarja Kask, Ralf Lõoke, Karli Luik) projekteeritud hoonetest, koostööst klientidega, konkurssidel osalemisest, võidetud preemiatest. Pikemalt Tallinnasse püstitatud Põhuteatrist

  1. High BMI levels associate with reduced mRNA expression of IL10 and increased mRNA expression of iNOS (NOS2) in human frontal cortex

    DEFF Research Database (Denmark)

    Lauridsen, J K; Olesen, R H; Vendelbo, J

    2017-01-01

    unknown. Therefore we aim to examine the relationship between BMI and gene expression of central inflammatory markers in the human frontal cortex. Microarray data of 141 neurologically and psychiatrically healthy individuals were obtained through the BrainCloud database. A simple linear regression...... correlated (Plinear regression analyses with BMI, age, sex and race as variables were performed in order to identify potential confounders. In conclusion, increasing BMI could affect the IL10-mediated anti...... analysis was performed with BMI as variable on data on IL10, IL1β, IL6, PTGS2 (COX2) and NOS2 (iNOS). Increasing BMI is associated with a decrease in the mRNA expression of IL10 (P=0.014) and an increase in the expression of NOS2 (iNOS; P=0.040). Expressions of IL10 and NOS2 (iNOS) were negatively...

  2. High BMI levels associate with reduced mRNA expression of IL10 and increased mRNA expression of iNOS (NOS2) in human frontal cortex

    DEFF Research Database (Denmark)

    Lauridsen, J K; Olesen, R H; Vendelbo, J

    2017-01-01

    analysis was performed with BMI as variable on data on IL10, IL1β, IL6, PTGS2 (COX2) and NOS2 (iNOS). Increasing BMI is associated with a decrease in the mRNA expression of IL10 (P=0.014) and an increase in the expression of NOS2 (iNOS; P=0.040). Expressions of IL10 and NOS2 (iNOS) were negatively...... correlated (PIL10 was mostly affected by individuals with BMI ⩾40. Multiple linear regression analyses with BMI, age, sex and race as variables were performed in order to identify potential confounders. In conclusion, increasing BMI could affect the IL10-mediated anti...

  3. TERMOS AMBIENTAIS E SOCIAIS NOS RELATÓRIOS DA ADMINISTRAÇÃO

    Directory of Open Access Journals (Sweden)

    Ilse Maria Beuren

    2012-07-01

    Full Text Available O estudo objetiva verificar a tendência dos termos ambientais e sociais evidenciados nos relatórios da administração de 1997 a 2006 de empresas familiares brasileiras. Realizou-se pesquisa exploratória, com abordagem qualitativa, por meio de pesquisa documental e da técnica de análise de conteúdo nos RA de 1997 a 2006. No universo das 500 maiores empresas listadas na Revista Exame, edição 2006, identificaram-se 21 empresas familiares de capital aberto e de controle acionário brasileiro, mas dessas somente 16 publicaram seu RA nos dez anos considerados. Os resultados mostram que a oscilação na quantidade de páginas dos RA ao longo dos anos apresenta relação com algum evento ocorrido nas empresas. A evidenciação dos termos ambientais está mais relacionada às medidas tomadas para cuidar e preservar o meio ambiente do que aos passivos ambientais. A evidenciação dos termos sociais foi direcionada de maneira equilibrada ao público interno e externo. Conclui-se que há uma tendência nos termos ambientais e sociais evidenciados nos RA de 1997 a 2006 das empresas pesquisadas, ainda que tenham sido incorporados vários termos novos ao longo do período.

  4. Population structure from NOS genes correlates with geographical differences in coronary incidence across Europe.

    Science.gov (United States)

    Carreras-Torres, Robert; Ferran, Albert; Zanetti, Daniela; Esteban, Esther; Varesi, Laurent; Pojskic, Naris; Coia, Valentina; Chaabani, Hassen; Via, Marc; Moral, Pedro

    2016-12-01

    The population analysis of cardiovascular risk and non-risk genetic variation can help to identify adaptive or random demographic processes that shaped coronary incidence variation across geography. In this study, 114 single nucleotide polymorphisms and 17 tandem repeat polymorphisms from Nitric Oxide Synthases (NOS) regions were analyzed in 1686 individuals from 35 populations from Europe, North Africa, and the Middle East. NOS genes encode for key enzymes on nitric oxide availability, which is involved in several cardiovascular processes. These genetic variations were used to test for selection and to infer the population structure of NOS regions. Moreover, we tested whether the variation in the incidence of coronary events and in the levels of classical risk factors in 11 of these European populations could be explained by the population structure estimates. Our results supported, first, the absence of clear signs of selection for NOS genetic variants associated with cardiovascular diseases, and second, the presence of a continuous genetic pattern of variation across European and North African populations without a Mediterranean barrier for gene flow. Finally, population structure estimates from NOS regions are closely correlated with coronary event rates and classical risk parameters (explaining 39-98%) among European populations. Our results reinforce the hypothesis that genetic bases of cardiovascular diseases and associated complex phenotypes could be geographically shaped by random demographic processes. © 2016 Wiley Periodicals, Inc.

  5. Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma.

    Science.gov (United States)

    Morelatto, Rosana; Itoiz, María-Elina; Guiñazú, Natalia; Piccini, Daniel; Gea, Susana; López-de Blanc, Silvia

    2014-05-01

    The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied. Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative (p=0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found. NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes.

  6. Expression of leptin and iNOS in oral melanomas in dogs.

    Science.gov (United States)

    Greene, V R; Wilson, H; Pfent, C; Roethele, J; Carwile, J; Qin, Y; Grimm, E; Ellerhorst, J A

    2013-01-01

    Oral melanoma (OM) in dogs is an aggressive malignancy, with clinical behavior resembling cutaneous melanomas in humans. Melanoma in humans is promoted by an inflammatory environment that is contributed to by leptin and inducible nitric oxide synthase (iNOS). To determine if the patterns of leptin and iNOS expression are similar in OM in dogs and cutaneous melanomas in humans. Twenty client-owned dogs. Retrospective case study. Immunostaining of the OM tumors from each dog was scored for percentage and intensity of leptin and iNOS expression. Mitotic index was used as an indicator of tumor aggression. Leptin was detected in ≥75% of the tumor cells in specimens from 11 dogs. One tumor expressed leptin in ≤25% of the cells. The intensity of leptin expression was variable with 6, 9, and 5 cases exhibiting low-, moderate-, and high-intensity staining, respectively. OM with the lowest percentage of iNOS positive cells displayed the highest mitotic indices (P = .006, ANOVA). The expression of leptin is a common finding in melanomas in dogs. These data suggest that the possibility of future clinical applications, such as measuring the concentrations of plasma leptin as a screening tool or leptin as a target for therapy. The relevance of iNOS is not as clear in dogs with OM, for which other directed therapeutics might be more appropriate. Copyright © 2013 by the American College of Veterinary Internal Medicine.

  7. Assessing depression outcome in patients with moderate dementia: sensitivity of the HoNOS65+ scale.

    Science.gov (United States)

    Canuto, Alessandra; Rudhard-Thomazic, Valérie; Herrmann, François R; Delaloye, Christophe; Giannakopoulos, Panteleimon; Weber, Kerstin

    2009-08-15

    To date, there is no widely accepted clinical scale to monitor the evolution of depressive symptoms in demented patients. We assessed the sensitivity to treatment of a validated French version of the Health of the Nation Outcome Scale (HoNOS) 65+ compared to five routinely used scales. Thirty elderly inpatients with ICD-10 diagnosis of dementia and depression were evaluated at admission and discharge using paired t-test. Using the Brief Psychiatric Rating Scale (BPRS) "depressive mood" item as gold standard, a receiver operating characteristic curve (ROC) analysis assessed the validity of HoNOS65+F "depressive symptoms" item score changes. Unlike Geriatric Depression Scale, Mini Mental State Examination and Activities of Daily Living scores, BPRS scores decreased and Global Assessment Functioning Scale score increased significantly from admission to discharge. Amongst HoNOS65+F items, "behavioural disturbance", "depressive symptoms", "activities of daily life" and "drug management" items showed highly significant changes between the first and last day of hospitalization. The ROC analysis revealed that changes in the HoNOS65+F "depressive symptoms" item correctly classified 93% of the cases with good sensitivity (0.95) and specificity (0.88) values. These data suggest that the HoNOS65+F "depressive symptoms" item may provide a valid assessment of the evolution of depressive symptoms in demented patients.

  8. iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants

    Science.gov (United States)

    Cassini-Vieira, Puebla; Araújo, Fernanda Assis; da Costa Dias, Filipi Leles; Russo, Remo Castro; Andrade, Silvia Passos; Teixeira, Mauro Martins; Barcelos, Luciola Silva

    2015-01-01

    There is considerable interest in implantation techniques and scaffolds for tissue engineering and, for safety and biocompatibility reasons, inflammation, angiogenesis, and fibrosis need to be determined. The contribution of inducible nitric oxide synthase (iNOS) in the regulation of the foreign body reaction induced by subcutaneous implantation of a synthetic matrix was never investigated. Here, we examined the role of iNOS in angiogenesis, inflammation, and collagen deposition induced by polyether-polyurethane synthetic implants, using mice with targeted disruption of the iNOS gene (iNOS−/−) and wild-type (WT) mice. The hemoglobin content and number of vessels were decreased in the implants of iNOS−/− mice compared to WT mice 14 days after implantation. VEGF levels were also reduced in the implants of iNOS−/− mice. In contrast, the iNOS−/− implants exhibited an increased neutrophil and macrophage infiltration. However, no alterations were observed in levels of CXCL1 and CCL2, chemokines related to neutrophil and macrophage migration, respectively. Furthermore, the implants of iNOS−/− mice showed boosted collagen deposition. These data suggest that iNOS activity controls inflammation, angiogenesis, and fibrogenesis in polyether-polyurethane synthetic implants and that lack of iNOS expression increases foreign body reaction to implants in mice. PMID:26106257

  9. Modulation of liver mitochondrial NOS is implicated in thyroid-dependent regulation of O(2) uptake.

    Science.gov (United States)

    Carreras, M C; Peralta, J G; Converso, D P; Finocchietto, P V; Rebagliati, I; Zaninovich, A A; Poderoso, J J

    2001-12-01

    Changes in O(2) uptake at different thyroid status have been explained on the basis of the modulation of mitochondrial enzymes and membrane biophysical properties. Regarding the nitric oxide (NO) effects, we tested whether liver mitochondrial nitric oxide synthase (mtNOS) participates in the modulation of O(2) uptake in thyroid disorders. Wistar rats were inoculated with 400 microCi (131)I (hypothyroid group), 20 microg thyroxine (T(4))/100 g body wt administered daily for 2 wk (hyperthyroid group) or vehicle (control). Basal metabolic rate, mitochondrial function, and mtNOS activity were analyzed. Systemic and liver mitochondrial O(2) uptake and cytochrome oxidase activity were lower in hypothyroid rats with respect to controls; mitochondrial parameters were further decreased by L-arginine (-42 and -34%, P activity (260%) were selectively increased in hypothyroidism and reverted by hormone replacement without changes in other nitric oxide isoforms. Moreover, mtNOS activity correlated with serum 3,5,3'-triiodothyronine (T(3)) and O(2) uptake. Increased mtNOS activity was also observed in skeletal muscle mitochondria from hypothyroid rats. Therefore, we suggest that modulation of mtNOS is a substantial part of thyroid effects on mitochondrial O(2) uptake.

  10. The protein inhibitor of nNOS (PIN/DLC1/LC8) binding does not inhibit the NADPH-dependent heme reduction in nNOS, a key step in NO synthesis.

    Science.gov (United States)

    Parhad, Swapnil S; Jaiswal, Deepa; Ray, Krishanu; Mazumdar, Shyamalava

    2016-03-25

    The neuronal nitric oxide synthase (nNOS) is an essential enzyme involved in the synthesis of nitric oxide (NO), a potent neurotransmitter. Although previous studies have indicated that the dynein light chain 1 (DLC1) binding to nNOS could inhibit the NO synthesis, the claim is challenged by contradicting reports. Thus, the mechanism of nNOS regulation remained unclear. nNOS has a heme-bearing, Cytochrome P450 core, and the functional enzyme is a dimer. The electron flow from NADPH to Flavin, and finally to the heme of the paired nNOS subunit within a dimer, is facilitated upon calmodulin (CaM) binding. Here, we show that DLC1 binding to nNOS-CaM complex does not affect the electron transport from the reductase to the oxygenase domain. Therefore, it cannot inhibit the rate of NADPH-dependent heme reduction in nNOS, which results in l-Arginine oxidation. Also, the NO release activity does not decrease with increasing DLC1 concentration in the reaction mix, which further confirmed that DLC1 does not inhibit nNOS activity. These findings suggest that the DLC1 binding may have other implications for the nNOS function in the cell. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.

    Science.gov (United States)

    Cerqueira, Fernanda M; Laurindo, Francisco R M; Kowaltowski, Alicia J

    2011-03-31

    Enhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR). Since treatment of mice with dinitrophenol (DNP) promotes health and lifespan benefits similar to those observed in CR, we hypothesized that it could also impact biogenesis. We found that DNP and CR increase citrate synthase activity, PGC-1α, cytochrome c oxidase and mitofusin-2 expression, as well as fasting plasma levels of NO• products. In addition, eNOS and Akt phosphorylation in skeletal muscle and visceral adipose tissue was activated in fasting CR and DNP animals. Overall, our results indicate that systemic mild uncoupling activates eNOS and Akt-dependent pathways leading to mitochondrial biogenesis.

  12. Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.

    Directory of Open Access Journals (Sweden)

    Fernanda M Cerqueira

    2011-03-01

    Full Text Available Enhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR. Since treatment of mice with dinitrophenol (DNP promotes health and lifespan benefits similar to those observed in CR, we hypothesized that it could also impact biogenesis. We found that DNP and CR increase citrate synthase activity, PGC-1α, cytochrome c oxidase and mitofusin-2 expression, as well as fasting plasma levels of NO• products. In addition, eNOS and Akt phosphorylation in skeletal muscle and visceral adipose tissue was activated in fasting CR and DNP animals. Overall, our results indicate that systemic mild uncoupling activates eNOS and Akt-dependent pathways leading to mitochondrial biogenesis.

  13. Fluxo do transporte de suínos para abate no Estado de Mato Grosso

    OpenAIRE

    Pereira,Thuanny Lúcia; Corassa,Anderson

    2014-01-01

    Objetivou-se descrever o fluxo de suínos para abate produzidos no Estado de Mato Grosso entre os anos de 2008 e 2012. Foram utilizados dados de 9.426.729 suínos produzidos no Estado de Mato Grosso e transportados para abate de janeiro de 2008 a dezembro de 2012, no qual realizou-se análise descritiva das informações, com frequências de origem e destino; machos e fêmeas em função dos meses e anos e as distâncias percorridas. Observou-se crescimento no número de viagens e de suínos transportado...

  14. Synthesis of a Potent Aminopyridine-Based nNOS-Inhibitor by Two Recent No-Carrier-Added $^{18}$F-Labelling Methods

    OpenAIRE

    Drerup, Christian; Ermert, Johannes; Coenen, Heinrich Hubert

    2016-01-01

    Nitric oxide (NO), an important multifunctional signaling molecule, is produced by three isoforms of NO-synthase (NOS) and has been associated with neurodegenerative disorders. Selective inhibitors of the subtypes iNOS (inducible) or nNOS (neuronal) are of great interest for decoding neurodestructive key factors, and 18F-labelled analogues would allow investigating the NOS-function by molecular imaging with positron emission tomography. Especially, the highly selective nNOS inhibitor 6-((3-((...

  15. Effects of Paracetamol on NOS, COX, and CYP Activity and on Oxidative Stress in Healthy Male Subjects, Rat Hepatocytes, and Recombinant NOS

    Science.gov (United States)

    Trettin, Arne; Böhmer, Anke; Suchy, Maria-Theresia; Probst, Irmelin; Staerk, Ulrich; Stichtenoth, Dirk O.; Frölich, Jürgen C.

    2014-01-01

    Paracetamol (acetaminophen) is a widely used analgesic drug. It interacts with various enzyme families including cytochrome P450 (CYP), cyclooxygenase (COX), and nitric oxide synthase (NOS), and this interplay may produce reactive oxygen species (ROS). We investigated the effects of paracetamol on prostacyclin, thromboxane, nitric oxide (NO), and oxidative stress in four male subjects who received a single 3 g oral dose of paracetamol. Thromboxane and prostacyclin synthesis was assessed by measuring their major urinary metabolites 2,3-dinor-thromboxane B2 and 2,3-dinor-6-ketoprostaglandin F1α, respectively. Endothelial NO synthesis was assessed by measuring nitrite in plasma. Urinary 15(S)-8-iso-prostaglanding F2α was measured to assess oxidative stress. Plasma oleic acid oxide (cis-EpOA) was measured as a marker of cytochrome P450 activity. Upon paracetamol administration, prostacyclin synthesis was strongly inhibited, while NO synthesis increased and thromboxane synthesis remained almost unchanged. Paracetamol may shift the COX-dependent vasodilatation/vasoconstriction balance at the cost of vasodilatation. This effect may be antagonized by increasing endothelial NO synthesis. High-dosed paracetamol did not increase oxidative stress. At pharmacologically relevant concentrations, paracetamol did not affect NO synthesis/bioavailability by recombinant human endothelial NOS or inducible NOS in rat hepatocytes. We conclude that paracetamol does not increase oxidative stress in humans. PMID:24799980

  16. Religião e patriotismo: o anticomunismo católico nos Estados Unidos e no Brasil nos anos da Guerra Fria

    Directory of Open Access Journals (Sweden)

    Carla Simone Rodeghero

    2002-01-01

    Full Text Available O artigo analisa e compara o anticomunismo católico no Brasil e nos Estados Unidos no período da Guerra Fria. Depois de situar o campo de estudos constituído no Brasil sobre o tema, discute as relações entre americanismo e anticomunismo, procurando situar o catolicismo norte-americano neste meio. Utiliza-se de uma produção recente sobre cultura da Guerra Fria nos Estados Unidos. Levanta, finalmente, uma série de elementos de comparação sobre a forma que o anticomunismo católico assumiu nos dois países.This article analyses and compares the Catholic anticommunism in the Brazil and in United States during the Cold War years. After showing the recent studies produced in Brazil about the fight against communism, it discusses the relationship between Americanism, anticommunism and Catholicism. This step is based on recent historical research about the Cold War culture in the United States. Finally, it makes comparisons between the forms that anticommunism assumed in each country.

  17. Intoxicação experimental de suínos por fumonisinas

    Directory of Open Access Journals (Sweden)

    Dilkin Paulo

    2004-01-01

    Full Text Available Os efeitos da exposição oral prolongada (28 dias à fumonisina foram estudados em suínos jovens. Os animais foram divididos em três grupos experimentais e alimentados com ração ad libitum contendo: A 0mg de FB1.kg-1 (controle; B 10mg de FB1.kg-1; C 30mg de FB1.kg-1. Os suínos foram observados duas vezes por dia; seus pesos e consumo alimentar foram registrados semanalmente. Entre o 20º e 24º dia de intoxicação, os suínos do tratamentos C apresentaram diminuição do consumo de ração e ganho de peso, sinais característicos de edema pulmonar, razão pela qual um animal foi levado a óbito aos 23 dias de intoxicação. Após 28 dias, os animais foram necropsiados e os órgãos submetidos a análises macroscópica, histopatológica e ao estudo da morfologia e histologia intestinal. Nos suínos que apresentaram sinais clínicos de intoxicação, observaram-se lesões pulmonares, hepáticas e diminuição de altura das vilosidades e profundidade das criptas e hiperplasia glandular em segmentos intestinais. Conclui-se, portanto, que substanciais perdas de produtividade podem ser induzidas em suínos alimentados com ração contaminada com baixos níveis de fumonisinas.

  18. Inducible nitric oxide synthase (iNOS) regulatory region variation in non-human primates.

    Science.gov (United States)

    Roodgar, Morteza; Ross, Cody T; Kenyon, Nicholas J; Marcelino, Gretchen; Smith, David Glenn

    2015-04-01

    Inducible nitric oxide synthase (iNOS) is an enzyme that plays a key role in intracellular immune response against respiratory infections. Since various species of nonhuman primates exhibit different levels of susceptibility to infectious respiratory diseases, and since variation in regulatory regions of genes is thought to play a key role in expression levels of genes, two candidate regulatory regions of iNOS were mapped, sequenced, and compared across five species of nonhuman primates: African green monkeys (Chlorocebus sabaeus), pig-tailed macaques (Macaca nemestrina), cynomolgus macaques (Macaca fascicularis), Indian rhesus macaques (Macaca mulatta), and Chinese rhesus macaques (M. mulatta). In addition, we conducted an in silico analysis of the transcription factor binding sites associated with genetic variation in these two candidate regulatory regions across species. We found that only one of the two candidate regions showed strong evidence of involvement in iNOS regulation. Specifically, we found evidence of 13 conserved binding site candidates linked to iNOS regulation: AP-1, C/EBPB, CREB, GATA-1, GATA-3, NF-AT, NF-AT5, NF-κB, KLF4, Oct-1, PEA3, SMAD3, and TCF11. Additionally, we found evidence of interspecies variation in binding sites for several regulatory elements linked to iNOS (GATA-3, GATA-4, KLF6, SRF, STAT-1, STAT-3, OLF-1 and HIF-1) across species, especially in African green monkeys relative to other species. Given the key role of iNOS in respiratory immune response, the findings of this study might help guide the direction of future studies aimed to uncover the molecular mechanisms underlying the increased susceptibility of African green monkeys to several viral and bacterial respiratory infections. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. Textura do solo e a estimativa do teor de água no ponto de murcha permanente com psicrômetro Soil texture and the estimation by Dewpoint Potential Meter of water retention at wilting point

    Directory of Open Access Journals (Sweden)

    Vilson Antonio Klein

    2010-07-01

    Full Text Available A determinação do volume de água disponível às plantas é fundamental para o correto manejo da irrigação e definição quanto ao uso dos solos agrícolas. Os principais fatores que exercem influência na retenção e disponibilidade de água às plantas são a textura e a estrutura do solo. O objetivo deste trabalho foi quantificar a influência da textura na retenção da água, na condição de ponto de murcha permanente (PMP das plantas (-1,5MPa, sendo utilizado um psicrômetro modelo WP4-T. Determinaram-se a textura de 100 amostras de solo e o teor de água no PMP. Os resultados indicaram que, em potenciais maiores que -1,0MPa, o psicrômetro mostrou-se pouco preciso, não se recomendando a sua utilização nessa condição. O PMP aumentou de 0,059 para 0,29g g-1, quando o teor de argila aumentou de 120 para 779g kg-1. Obteve-se um bom ajuste dos resultados do teor de água no PMP em função do teor de argila do solo, e 91% da variação do teor de água no PMP puderam ser atribuídos à variação no teor de argila. Conclui-se que o psicrômetro é um equipamento que pode ser utilizado para determinar o PMP, e a equação PMP (g g-1=0,0003*Argila (g kg-1+0,0118 pode ser utilizada para estimar o PMP.The determination of the available water to plants is essential to right irrigation management and definition regarding the use in agricultural soils. The main factors that exert influence on retention and availability of water to plants are texture and soil structure. The aim of this study was to quantify the influence of the texture on water retention in the condition of permanent wilting point (PWP of plants (-1,5MPa using a WP4-T Dewpoint Potentia Meter. The texture of 100 soil sample and soil moisture at PWP was determined. Results indicated that, in potentials higher than -1,0MPa, WP4-T seemed not very precise, therefore its use is not recommended in this condition. PWP increased from 0,059 to 0,29g g-1, while the clay content

  20. Análise comparativa de envoltórios para drenos tubulares em condições de fluxo não-permanente Comparative analysis of envelopes for tubular drains under non-steady state flow conditions

    Directory of Open Access Journals (Sweden)

    Denise M. de Almeida

    2001-04-01

    Full Text Available Com esta pesquisa, objetivou-se avaliar a eficiência de envoltórios em drenos tubulares sob condições de fluxo não-permanente; para tanto, foram utilizados, em tanques de alvenaria, os envoltórios de geotêxteis XT-4, XT-2, bidim OP-30 e bidim OP-20, envelopes de brita no 1, com espessuras de 0,05, 0,10 e 0,15 m, além de um tratamento com ausência de envoltório. As variáveis-resposta utilizadas para se testar os tratamentos consistiram da lâmina drenada num tempo de 30 min, da massa de areia carreada após este tempo de drenagem e do desempenho hidráulico dos drenos, com base no cálculo da resistência de entrada ao fluxo e da relação entre vazão e carga hidráulica a 0,55 m da interface solo-dreno. As lâminas drenadas não diferiram estatisticamente a nível de 5% de probabilidade; no entanto, os geotêxteis bidim OP-20 e XT-4 mostraram-se, nesta ordem, como as melhores opções, face à análise de desempenho e se considerando os aspectos custo e facilidade de instalação. Quanto à análise da variável carreamento de areia, verificou-se a influência da espessura do envoltório ao se analisar os tratamentos com brita, além da opção das mantas, como excelente filtro. Os dados de resistência de entrada demonstraram a importância do uso de envoltórios ao se comparar o tratamento sem envoltório (r ent = 0,0102 d m-1 com o tratamento brita 0,15m (r ent = 0,0032 d m-1 cuja redução foi de 68,7%.The aim of the research was to evaluate the performance of eight types of envelopes installed around tubular drains in a horizontal tank model, with the treatments bidim OP-20, bidim OP-30, XT-2 and XT-4, 0.15, 0.10 and 0.05 m thick gravel and the treatment drain without a wrapper. The response-variables for the treatments used consisted of the depth of water drained in thirty minutes, the mass of sediment transported by the water during this same time interval and the hydraulic performance of the drains based on the entrance

  1. Nutrição e produção da laranjeira "Folha Murcha" em porta-enxertos e plantas de cobertura permanente na entrelinha Nutrition and yield of the 'Folha Murcha' orange in rootstocks and groundcover management systems

    Directory of Open Access Journals (Sweden)

    Jonez Fidalski

    2006-06-01

    Full Text Available O estado nutricional e a produção de citros não são conhecidos para as diferentes combinações copa/porta-enxertos e plantas de coberturas permanente na entrelinha. O estudo foi instalado em um experimento de laranjeira "Folha Murcha" [Citrus sinensis (L. Osb.] com oito anos de idade, conduzido entre 1997 a 2002, no município de Paranavaí, região Noroeste do Paraná. O solo corresponde a um Argissolo Vermelho distr��fico típico textura areia/franco arenoso. O delineamento experimental foi de blocos ao acaso, sendo os tratamentos constituídos por sete porta-enxertos: limoeiro "Cravo", limoeiro "Rugoso da África", limoeiro "Volcameriano", tangerineira "Cleópatra", tangerineira "Sunki", citrangeiro "C-13" e Trifoliata, com três plantas em cada parcela experimental. As repetições foram constituídas por três blocos com a cobertura Paspalum notatum e por um bloco com Arachis pintoi. Foram avaliados os teores dos nutrientes foliares e a produção de frutos da laranjeira "Folha Murcha". O manejo das entrelinhas com a leguminosa elevou os teores de N à faixa excessiva nas folhas do porta-enxerto limoeiro "Cravo", e reduziu a produção de frutos da laranjeira "Folha Murcha" em relação à gramínea. Nas entrelinhas com gramínea, a produção de frutos da laranjeira "Folha Murcha" foi dependente das safras agrícolas e dos teores foliares de Ca, Mg e Zn. A absorção máxima de Ca pelas folhas de laranjeira "Folha Murcha" precede a de Mg e Zn. Nestas condições, os porta-enxertos tangerineira "Cleópatra" e limoeiro "Rugoso da África" apresentaram maior produção de frutos de laranjeira "Folha Murcha".The nutritional status and yield of citrus are not known for different canopy/rootstocks and soil groundcover management systems. The study was set up in a 8-year-old 'Folha Murcha' [Citrus sinensis (L. Osb.] orange experiment, and was carried out from 1997 to 2002 in Paranavai, in the northwest region of the state of Parana

  2. A vast amount of various invariant tori in the Nosé-Hoover oscillator.

    Science.gov (United States)

    Wang, Lei; Yang, Xiao-Song

    2015-12-01

    This letter restudies the Nosé-Hoover oscillator. Some new averagely conservative regions are found, each of which is filled with different sequences of nested tori with various knot types. Especially, the dynamical behaviors near the border of "chaotic region" and conservative regions are studied showing that there exist more complicated and thinner invariant tori around the boundaries of conservative regions bounded by tori. Our results suggest an infinite number of island chains in a "chaotic sea" for the Nosé-Hoover oscillator.

  3. A vast amount of various invariant tori in the Nosé-Hoover oscillator

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Lei [School of Mathematics and Statistics, Huazhong University of Science and Technology, Wuhan 430074 (China); Department of Mathematics and Physics, Hefei University, Hefei 230601 (China); Yang, Xiao-Song, E-mail: yangxs@hust.edu.cn [School of Mathematics and Statistics, Huazhong University of Science and Technology, Wuhan 430074 (China)

    2015-12-15

    This letter restudies the Nosé-Hoover oscillator. Some new averagely conservative regions are found, each of which is filled with different sequences of nested tori with various knot types. Especially, the dynamical behaviors near the border of “chaotic region” and conservative regions are studied showing that there exist more complicated and thinner invariant tori around the boundaries of conservative regions bounded by tori. Our results suggest an infinite number of island chains in a “chaotic sea” for the Nosé-Hoover oscillator.

  4. A vast amount of various invariant tori in the Nosé-Hoover oscillator

    Science.gov (United States)

    Wang, Lei; Yang, Xiao-Song

    2015-12-01

    This letter restudies the Nosé-Hoover oscillator. Some new averagely conservative regions are found, each of which is filled with different sequences of nested tori with various knot types. Especially, the dynamical behaviors near the border of "chaotic region" and conservative regions are studied showing that there exist more complicated and thinner invariant tori around the boundaries of conservative regions bounded by tori. Our results suggest an infinite number of island chains in a "chaotic sea" for the Nosé-Hoover oscillator.

  5. Circulating NOS3 modulates left ventricular remodeling following reperfused myocardial infarction.

    Directory of Open Access Journals (Sweden)

    Simone Gorressen

    Full Text Available Nitric oxide (NO is constitutively produced and released from the endothelium and several blood cell types by the isoform 3 of the NO synthase (NOS3. We have shown that NO protects against myocardial ischemia/reperfusion (I/R injury and that depletion of circulating NOS3 increases within 24 h of ischemia/reperfusion the size of myocardial infarction (MI in chimeric mice devoid of circulating NOS3. In the current study we hypothesized that circulating NOS3 also affects remodeling of the left ventricle following reperfused MI.To analyze the role of circulating NOS3 we transplanted bone marrow of NOS3-/- and wild type (WT mice into WT mice, producing chimerae expressing NOS3 only in vascular endothelium (BC-/EC+ or in both, blood cells and vascular endothelium (BC+/EC+. Both groups underwent 60 min of coronary occlusion in a closed-chest model of reperfused MI. During the 3 weeks post MI, structural and functional LV remodeling was serially assessed (24 h, 4 d, 1 w, 2 w and 3 w by echocardiography. At 72 hours post MI, gene expression of several extracellular matrix (ECM modifying molecules was determined by quantitative RT-PCR analysis. At 3 weeks post MI, hemodynamics were obtained by pressure catheter, scar size and collagen content were quantified post mortem by Gomori's One-step trichrome staining.Three weeks post MI, LV end-systolic (53.2±5.9 μl; ***p≤0.001; n = 5 and end-diastolic volumes (82.7±5.6 μl; *p<0.05; n = 5 were significantly increased in BC-/EC+, along with decreased LV developed pressure (67.5±1.8 mm Hg; n = 18; ***p≤0.001 and increased scar size/left ventricle (19.5±1.5%; n = 13; **p≤0.01 compared to BC+/EC+ (ESV: 35.6±2.2 μl; EDV: 69.1±2.6 μl n = 8; LVDP: 83.2±3.2 mm Hg; n = 24; scar size/LV13.8±0.7%; n = 16. Myocardial scar of BC-/EC+ was characterized by increased total collagen content (20.2±0.8%; n = 13; ***p≤0.001 compared to BC+/EC+ (15.9±0.5; n = 16, and increased collagen type I and III subtypes

  6. Nitrous oxide discretely up-regulates nNOS and p53 in neonatal rat brain.

    Science.gov (United States)

    Cattano, D; Valleggi, S; Abramo, A; Forfori, F; Maze, M; Giunta, F

    2010-06-01

    Animal studies suggest that neuronal cell death often results from anesthetic administration during synaptogenesis. Volatile anesthetics are strongly involved in triggering neuronal apoptosis, whereas other inhalational agents (xenon) demonstrate protective effects. Nitrous oxide (N2O) has modest pro-apoptotic effects on its own and potent, synergistic toxic effects when combined with volatile agents. Recent findings suggest that, during periods of rapid brain development, the enhanced neurodegeneration triggered by anesthetic drugs may be caused by a compensatory increase in intracellular free calcium, a potent activator of neuronal nitric oxide synthase (nNOS). Anesthesia-induced neuro-apoptosis is also activated via the intrinsic and the extrinsic apoptotic pathways because both pathways involve p53, a key regulatory gene. The molecular events related to neuronal cell apoptosis are not completely understood. To gain further insight into the events underlying neuro-apoptosis, we analyzed the transcriptional consequences of N2O exposure on nNOS, iNOS and p53 mRNA levels. The study used 2 groups of postnatal day seven Sprague/Dawley rats (N=6 each) that were exposed for 120 minutes to air (75% N2, 25% O2) or N2O (75% N2O, 25% O2; this N2O concentration is commonly used to induce anesthesia and has been demonstrated to trigger neurodegeneration in postnatal day seven rats). Total RNA was isolated from each brain and expression analyses on iNOS and nNOS transcripts were performed using relative Real-Time C-reactive protein PCR (using G3PDH as a housekeeping gene). A semi-quantitative RT-PCR analysis was performed on the p53 transcript (using Ciclophylin A as a housekeeping gene). Statistical analysis (REST 2005) revealed a significant, 11-fold up-regulation (P=0.026) of the nNOS transcript but no significant changes in iNOS transcription. The p53 mRNA was up-regulated almost 2-fold (P=0.0002; Student's t-Test; GraphPad Prism 4.00) in N2O-treated samples relative to

  7. O papel de imunoglobulinas na nefropatia da leptospirose em suínos

    Directory of Open Access Journals (Sweden)

    Larissa M.F. Gonçalves

    2014-06-01

    Full Text Available A leptospirose é uma antropozoonose endêmica em todo o mundo, que afeta o homem e várias espécies de animais domésticos e silvestres. No início da infecção há produção de IgM para o controle da infecção e após alguns dias, IgG são produzidas e provocam lise das leptospiras circulantes. Objetivou-se neste estudo identificar depósitos de antígeno de leptospiras e imunoglobulinas no tecido renal, para avaliar o papel de imunoglobulinas na patogênese da nefropatia da leptospirose em suínos. Foram colhidas 139 amostras de sangue e rim de suínos das cidades de Teresina/PI e Timon/MA, que foram avaliadas pela SAM, imunoistoquímica e PCR. Nefrite intersticial, fibrose, vasculite, tumefação do tufo glomerular e hipercelularidade difusa foram as principais alterações histopatológicas encontradas. A imunoistoquímica detectou antígeno de leptospira em 60 suínos. Depósitos de IgG, IgM e IgA foram observados no endotélio de capilares glomerulares, dos capilares intertubulares e na cápsula de Bowman, com marcação focal, difusa, global e segmentar. A deposição de IgM e IgA foi significantemente maior nos suínos infectados. Estranhamente depósitos de IgG foi significantemente maior nos suínos não infectados, onde não havia presença de antígeno de leptospiras e nem lesão túbulo-intersticial. Concluímos que antígeno de leptospiras no rim de suínos está relacionado a depósitos de IgM e IgA mas não a depósitos de IgG.

  8. ICoNOs MM: The IT-enabled Collaborative Networked Organizations Maturity Model

    NARCIS (Netherlands)

    Santana Tapia, R.G.

    2009-01-01

    The focus of this paper is to introduce a comprehensive model for assessing and improving maturity of business-IT alignment (B-ITa) in collaborative networked organizations (CNOs): the ICoNOs MM. This two dimensional maturity model (MM) addresses five levels of maturity as well as four domains to

  9. Resting Tension Affects eNOS Activity in a Calcium-Dependent Way in Airways

    Directory of Open Access Journals (Sweden)

    Paschalis-Adam Molyvdas

    2007-03-01

    Full Text Available The alteration of resting tension (RT from 0.5 g to 2.5 g increased significantly airway smooth muscle contractions induced by acetylcholine (ACh in rabbit trachea. The decrease in extracellular calcium concentration [Ca2+]o from 2 mM to 0.2 mM reduced ACh-induced contractions only at 2.5 g RT with no effect at 0.5 g RT. The nonselective inhibitor of nitric oxide synthase (NOS, NG-nitro-L-arginine methyl ester (L-NAME increased ACh-induced contractions at 2.5 g RT. The inhibitor of inducible NOS, S-methylsothiourea or neuronal NOS, 7-nitroindazole had no effect. At 2.5 g RT, the reduction of [Ca2+]o from 2 mM to 0.2 mM abolished the effect of L-NAME on ACh-induced contractions. The NO precursor L-arginine or the tyrosine kinase inhibitors erbstatin A and genistein had no effect on ACh-induced contractions obtained at 2.5 g RT. Our results suggest that in airways, RT affects ACh-induced contractions by modulating the activity of epithelial NOS in a calcium-dependent, tyrosine-phosphorylation-independent way.

  10. Induction of expression of iNOS by N-nitrosodimethylamine (NDMA) in human leukocytes.

    Science.gov (United States)

    Ratajczak-Wrona, Wioletta; Jablonska, Ewa; Jablonski, Jakub; Marcinczyk, Magdalena

    2009-01-01

    The aim of this study was to assess the influence of N-nitrosodimethylamine (NDMA) on expression of inducible nitric oxide synthase (iNOS), as well as production of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) by human neutrophils (PMN) and peripheral blood mononuclear cells (PBMC), and the participation of the p38 MAPK kinase in this process. Furthermore, the ability of neutrophils to release superoxide anion was determined. The influence of N-nitrosodimethylamine on iNOS expression was determined in isolated PMN and PBMC cells from peripheral blood of healthy individuals. The mononuclear cells showed higher sensitivity to NDMA. Moreover, cytotoxic effect of NDMA can be influenced in some way by the impact of this xenobiotic on nitric oxide and superoxide anion release from human leukocytes. Furthermore, increased generation of these radicals by human leukocytes suggest that neutrophils and mononuclear cells that are exposed to NDMA activity can play a key role in endogenous NDMA generation. However the relationship between iNOS expression and phospho-p38 MAPK in neutrophils and mononuclear cells shows that p38 MAPK pathway participates in induction of iNOS expression in the presence of NDMA.

  11. Inhibition of iNOS and DNA Oxidation by Methanol Extract of ...

    African Journals Online (AJOL)

    Purpose: To investigate the antioxidant properties of the methanol extract of S. tenuifolia as well as its effect on inducible nitric oxide synthase (iNOS) and cycleooxygenase-2 (COX-2) expression in lipopolysaccharides (LPS)-induced cell damage in macrophage cells. Methods: The antioxidant activities of the plant extract ...

  12. nNOS inhibitors attenuate methamphetamine-induced dopaminergic neurotoxicity but not hyperthermia in mice.

    Science.gov (United States)

    Itzhak, Y; Martin, J L; Ail, S F

    2000-09-11

    Methamphetamine (METH)-induced dopaminergic neurotoxicity is associated with hyperthermia. We investigated the effect of several neuronal nitric oxide synthase (nNOS) inhibitors on METH-induced hyperthermia and striatal dopaminergic neurotoxicity. Administration of METH (5 mg/kg; q. 3 h x 3) to Swiss Webster mice produced marked hyperthermia and 50-60% depletion of striatal dopaminergic markers 72 h after METH administration. Pretreatment with the nNOS inhibitors S-methylthiocitrulline (SMTC; 10 mg/kg) or 3-bromo-7-nitroindazole (3-Br-7-NI; 20 mg/kg) before each METH injection did not affect the persistent hyperthermia produced by METH, but afforded protection against the depletion of dopaminergic markers. A low dose (25 mg/kg) of the nNOS inhibitor 7-nitroindazole (7-NI) did not affect METH-induced hyperthermia, but a high dose (50 mg/kg) produced significant hypothermia. These findings indicate that low dose of selective nNOS inhibitors protect against METH-induced neurotoxicity with no effect on body temperature and support the hypothesis that nitric oxide (NO) and peroxynitrite have a major role in METH-induced dopaminergic neurotoxicity.

  13. From Orthodoxy to Plurality in the Nature of Science (NOS) and Science Education: A Metacommentary

    Science.gov (United States)

    Bazzul, Jesse

    2017-01-01

    This article provides a metacommentary on the special issue on nature of science (NOS). The issue is composed of senior scholars discussing Hodson and Wong's (2017, this issue) critique of the consensus view of nature of science, which on a basic level states that there are agreed-upon aspects of science that can be taught in K-12 schools. Each…

  14. Role of iNOS in Bystander Signaling Between Macrophages and Lymphoma Cells

    International Nuclear Information System (INIS)

    Ghosh, Somnath; Maurya, Dharmendra Kumar; Krishna, Malini

    2008-01-01

    Purpose: The present report describes the bystander effects of radiation between similar and dissimilar cells and the role of iNOS in such communication. Materials and Methods: EL-4 and RAW 264.7 cells were exposed to 5 Gy γ-irradiation. The medium from irradiated cells was transferred to unirradiated cells. Results: Irradiated EL-4 cells as well as those cultured in the presence of medium from γ-irradiated EL-4 cells showed an upregulation of NF-κB, iNOS, p53, and p21/waf1 genes. The directly irradiated and the bystander EL-4 cells showed an increase in DNA damage, apoptosis, and NO production. Bystander signaling was also found to exist between RAW 264.7 (macrophage) and EL-4 (lymphoma) cells. Unstimulated or irradiated RAW 264.7 cells did not induce bystander effect in unirradiated EL-4 cells, but LPS stimulated and irradiated RAW 264.7 cells induced an upregulation of NF-κB and iNOS genes and increased the DNA damage in bystander EL-4 cells. Treatment of EL-4 or RAW 264.7 cells with L-NAME significantly reduced the induction of gene expression and DNA damage in the bystander EL-4 cells, whereas treatment with cPTIO only partially reduced the induction of gene expression and DNA damage in the bystander EL-4 cells. Conclusions: It was concluded that active iNOS in the irradiated cells was essential for bystander response

  15. Decreased NOS1 expression in the anterior cingulate cortex in depression

    NARCIS (Netherlands)

    Gao, Shang-Feng; Qi, Xin-Rui; Zhao, Juan; Balesar, Rawien; Bao, Ai-Min; Swaab, Dick F.

    2013-01-01

    Decreased function of the anterior cingulate cortex (ACC) is crucially involved in the pathogenesis of depression. A key role of nitric oxide (NO) has also been proposed. We aimed to determine the NO content in the cerebrospinal fluid (CSF) and the expression of NO synthase (NOS) isoforms, that is,

  16. Animal Certifié Conforme: Déchiffrer nos Relations avec le Vivant

    Directory of Open Access Journals (Sweden)

    Daniel W. Gade

    2014-01-01

    Full Text Available Review of Animal Certifié Conforme: Déchiffrer nos Relations avec le Vivant. Bernadette Lizet and Jacqueline Milliet, eds. 2012. Dunod/Muséum National d’Histoire Naturelle, Paris. Pp 256. €22 (paperback. ISBN 9782100582853.

  17. Neuronal Nitric Oxide Synthase (NOS1) Polymorphisms Interact with Financial Hardship to Affect Depression Risk

    Science.gov (United States)

    Sarginson, Jane E; Deakin, JF William; Anderson, Ian M; Downey, Darragh; Thomas, Emma; Elliott, Rebecca; Juhasz, Gabriella

    2014-01-01

    There is increasing evidence that genetic factors have a role in differential susceptibility to depression in response to severe or chronic adversity. Studies in animals suggest that nitric oxide (NO) signalling has a key role in depression-like behavioural responses to stress. This study investigated whether genetic variation in the brain-expressed nitric oxide synthase gene NOS1 modifies the relationship between psychosocial stress and current depression score. We recruited a population sample of 1222 individuals who provided DNA and questionnaire data on symptoms and stress. Scores on the List of Life-Threatening Experiences (LTE) questionnaire for the last year and self-rated current financial hardship were used as measures of recent/ongoing psychosocial stress. Twenty SNPs were genotyped. Significant associations between eight NOS1 SNPs, comprising two regional haplotypes, and current depression score were identified that survived correction for multiple testing when current financial hardship was used as the interaction term. A smaller three-SNP haplotypes (rs10507279, rs1004356 and rs3782218) located in a regulatory region of NOS1 showed one of the strongest effects, with the A-C-T haplotype associating with higher depression scores at low adversity levels but lower depression scores at higher adversity levels (p=2.3E-05). These results suggest that NOS1 SNPs interact with exposure to economic and psychosocial stressors to alter individual's susceptibility to depression. PMID:24917196

  18. Enhancing Students' NOS Views and Science Knowledge Using Facebook-Based Scientific News

    Science.gov (United States)

    Huang, Hsi-Yu; Wu, Hui-Ling; She, Hsiao-Ching; Lin, Yu-Ren

    2014-01-01

    This study investigated how the different discussion approaches in Facebook influenced students' scientific knowledge acquisition and the nature of science (NOS) views. Two eighth- and two ninth-grade classes in a Taiwanese junior high school participated in the study. In two of the classes students engaged in synchronous discussion, and in the…

  19. Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background

    Directory of Open Access Journals (Sweden)

    Sara N. Koenig

    2015-03-01

    Full Text Available Thoracic aortic aneurysms (TAA are a significant cause of morbidity and mortality in humans. While the exact etiology is unknown, genetic factors play an important role. Mutations in NOTCH1 have been linked to bicuspid aortic valve (BAV and aortopathy in humans. The aim of this study was to determine if haploinsufficiency of Notch1 contributes to aortopathy using Notch1+/−; Nos3−/− mice. Echocardiographic analysis of Notch1+/−; Nos3−/− mice reveals effacement of the sinotubular junction and a trend toward dilation of the aortic sinus. Furthermore, examination of the proximal aorta of Notch1+/−; Nos3−/− mice reveals elastic fiber degradation, a trend toward increased matrix metalloproteinase 2 expression, and increased smooth muscle cell apoptosis, features characteristic of aneurysmal disease. Although at a lower penetrance, we also found features consistent with aortopathic changes in Notch1 heterozygote mice and in Nos3-null mice. Our findings implicate a novel role for Notch1 in aortopathy of the proximal aorta.

  20. Association between nucleotide mutation of eNOS gene and serum ...

    African Journals Online (AJOL)

    Galaxy

    2013-05-15

    May 15, 2013 ... spasm among Japanese (Nakayama et al., 1999; Casas et al., 2006). It is believed that these mutations might result in altered NO metabolism and impaired .... ship between T-786C mutation of eNOS gene and CAD specifically in the Iranian population. To our knowledge, this polymorphism has never been ...

  1. Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts.

    NARCIS (Netherlands)

    Ayub, H.; Khan, M.I.; Micheal, S.; Akhtar, F.; Ajmal, M.; Shafique, S.; Ali, S.H.; Hollander, A.I. den; Ahmed, A.; Qamar, R.

    2010-01-01

    PURPOSE: To investigate the involvement of stress-regulating genes, endothelial nitric oxide synthase (eNOS) and heat shock protein 70 (HSP70) with primary open angle glaucoma (POAG) and primary closed angle glaucoma (PCAG). METHODS: POAG and PCAG patients recruited from different areas of Pakistan

  2. Morus alba extract modulates blood pressure homeostasis through eNOS signaling.

    Science.gov (United States)

    Carrizzo, Albino; Ambrosio, Mariateresa; Damato, Antonio; Madonna, Michele; Storto, Marianna; Capocci, Luca; Campiglia, Pietro; Sommella, Eduardo; Trimarco, Valentina; Rozza, Francesco; Izzo, Raffaele; Puca, Annibale A; Vecchione, Carmine

    2016-10-01

    Morus alba is a promising phytomedicine cultivated in oriental countries that is extensively used to prevent and treat various cardiovascular problems. To date, despite its beneficial effects, the molecular mechanisms involved remain unclear. Thus, we investigate the vascular and haemodynamic effects of Morus alba extract in an experimental model focusing our attention on the molecular mechanisms involved. Through vascular reactivity studies, we demonstrate that Morus alba extract evokes endothelial vasorelaxation through a nitric oxide-dependent pathway. Our molecular analysis highlights an increase in endothelial nitric oxide synthase (eNOS) phosphorylation. In vivo administration of Morus alba extract reduces blood pressure levels exclusively in wild-type mice, whereas it fails to evoke any haemodynamic effects in eNOS-deficient mice. Molecular analyses revealed that its beneficial action on vasculature is mediated by the activation of two important proteins that act as stress sensors and chaperones: PERK and heat shock protein 90. Finally, Morus alba extract exerts antihypertensive action in an experimental model of arterial hypertension. Through its action on eNOS signaling, Morus alba extract could act as a food supplement for the regulation of cardiovascular system, mainly in clinical conditions characterized by eNOS dysfunction, such as arterial hypertension. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Association of the NOS3 intron-4 VNTR polymorphism with aneurysmal subarachnoid hemorrhage

    DEFF Research Database (Denmark)

    Staalsø, Jonatan Myrup; Edsen, Troels; Kotinis, Alexandros

    2014-01-01

    OBJECT: The nitric oxide system has been linked to the pathogenesis of aneurysmal subarachnoid hemorrhage (SAH). The authors performed a case-control study to investigate the association between SAH and common genetic variants within the endothelial nitric oxide synthase gene (NOS3). METHODS: Thr...

  4. Neuronal nitric oxide synthase (NOS1) polymorphisms interact with financial hardship to affect depression risk.

    Science.gov (United States)

    Sarginson, Jane E; Deakin, J F William; Anderson, Ian M; Downey, Darragh; Thomas, Emma; Elliott, Rebecca; Juhasz, Gabriella

    2014-11-01

    There is increasing evidence that genetic factors have a role in differential susceptibility to depression in response to severe or chronic adversity. Studies in animals suggest that nitric oxide (NO) signalling has a key role in depression-like behavioural responses to stress. This study investigated whether genetic variation in the brain-expressed nitric oxide synthase gene NOS1 modifies the relationship between psychosocial stress and current depression score. We recruited a population sample of 1222 individuals who provided DNA and questionnaire data on symptoms and stress. Scores on the List of Life-Threatening Experiences (LTE) questionnaire for the last year and self-rated current financial hardship were used as measures of recent/ongoing psychosocial stress. Twenty SNPs were genotyped. Significant associations between eight NOS1 SNPs, comprising two regional haplotypes, and current depression score were identified that survived correction for multiple testing when current financial hardship was used as the interaction term. A smaller three-SNP haplotypes (rs10507279, rs1004356 and rs3782218) located in a regulatory region of NOS1 showed one of the strongest effects, with the A-C-T haplotype associating with higher depression scores at low adversity levels but lower depression scores at higher adversity levels (p=2.3E-05). These results suggest that NOS1 SNPs interact with exposure to economic and psychosocial stressors to alter individual's susceptibility to depression.

  5. Psychomteric Validation of the Health of Nation Outcome Scales (HoNOS) in Traumatized Refugees

    DEFF Research Database (Denmark)

    Palic, Sabina; Elklit, Ask; Makransky, Guido

    -treatment data from 448 consecutive patients at three Danish psychiatric clinics for refugees. A10-item HoNOS version (physical problems and daily function items excluded) of pre-treatment data fit the Rasch model well. A cross validation showed excellent fit of the post-treatment data to the 10-item model...

  6. 77 FR 12010 - Marine Mammals; File Nos. 1076-1789 and 14502

    Science.gov (United States)

    2012-02-28

    ... NMFS to study and document the health and biology of wild marine mammals as well as those marine... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XB040 Marine Mammals; File Nos. 1076-1789 and 14502 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic...

  7. Using Video Modeling to Teach Children with PDD-NOS to Respond to Facial Expressions

    Science.gov (United States)

    Axe, Judah B.; Evans, Christine J.

    2012-01-01

    Children with autism spectrum disorders often exhibit delays in responding to facial expressions, and few studies have examined teaching responding to subtle facial expressions to this population. We used video modeling to train 3 participants with PDD-NOS (age 5) to respond to eight facial expressions: approval, bored, calming, disapproval,…

  8. Sociodemographic, neuropsychiatric and cognitive characteristics of pathological gambling and impulse control disorders NOS in Parkinson's disease.

    Science.gov (United States)

    Pontieri, Francesco E; Assogna, Francesca; Pellicano, Clelia; Cacciari, Claudia; Pannunzi, Sara; Morrone, Annalucia; Danese, Emanuela; Caltagirone, Carlo; Spalletta, Gianfranco

    2015-01-01

    Despite of previous evidence supporting the association between impulse control disorder (ICD) and several demographic, clinical and therapeutic features in Parkinson's disease (PD), the relationships between pathological gambling (PG) or other variants of ICD (ICD-NOS) and specific neuropsychiatric or cognitive domains are not entirely defined. In this study, 155 PD patients without dementia or cognitive impairment underwent: i. the ICD diagnoses, using the Questionnaire for Impulsive-Compulsive Disorders, ii. the mood and anxiety disorders diagnoses, according to the DSM-IV-TR criteria, and iii. a comprehensive battery for measuring severity of psychopathology and neuropsychology domains. Patients were divided in those with pathological gambling (PG), ICDs not otherwise specified (ICD-NOS), or the lack of ICD (No-ICD). There was a progression in age and age at onset from the younger PG subjects throughout ICD-NOS to No-ICD. PG and ICD-NOS subjects had longer disease duration and were taking significantly higher dosages of antiparkinsonian drugs than No-ICD ones. PG subjects had significantly higher severity of depressive and anxious symptoms with respect to the other 2 groups. Both PG and ICD-NOS subjects suffer from increased severity of psychotic symptoms than No-ICD ones. The 3 groups did not differ in any cognitive measure. Our results support the concept that the different sociodemographic and neuropsychiatric profiles of PD patients are associated with different ICDs. Moreover, we clearly demonstrate the lack of relationship between ICD and cognitive performances in undemented PD patients. Copyright © 2014 Elsevier B.V. and ECNP. All rights reserved.

  9. Gender, exercise training, and eNOS expression in porcine skeletal muscle arteries.

    Science.gov (United States)

    Laughlin, M Harold; Welshons, Wade V; Sturek, Michael; Rush, James W E; Turk, James R; Taylor, Julia A; Judy, Barbara M; Henderson, Kyle K; Ganjam, V K

    2003-07-01

    Our purpose was to determine the effects of gender and exercise training on endothelial nitric oxide synthase (eNOS) and superoxide dismutase (SOD) protein content of porcine skeletal muscle arteries and to evaluate the role of 17beta-estradiol (E2) in these effects. We measured eNOS and SOD content with immunoblots and immunohistochemistry in femoral and brachial arteries of trained and sedentary male and female pigs and measured estrogen receptor (ER) mRNA and alpha-ER and beta-ER protein in aortas of male and female pigs. Results indicate that female arteries contain more eNOS than male arteries and that exercise training increases eNOS content independent of gender. Male and female pigs expressed similar levels of alpha-ER mRNA and protein and similar amounts beta-ER protein in their arteries. E2 concentrations as measured by RIA were 180 +/- 34 pg/ml in male sera and approximately 5 pg/ml in female sera, and neither was changed by training. However, bioassay indicated that biologically active estrogen equivalent to only 35 +/- 5 pg/ml was present in male sera. E2 in female pigs, whether measured by RIA or bioassay, was approximately 24 pg/ml at peak estrous and 2 pg/ml on day 5 diestrus. The free fraction of E2 in sera did not explain the low measurements, relative to RIA, of E2. We conclude that 1). gender has significant influence on eNOS and SOD content of porcine skeletal muscle arteries; 2). the effects of gender and exercise training vary among arteries of different anatomic origin; 3). male sera contains compounds that cause RIA to overestimate circulating estrogenic activity; and 4). relative to human men, the male pig is not biologically estrogenized by high levels of E2 reported by RIA, whereas in female pigs E2 levels are lower than in the blood of human women.

  10. Effects of a selective iNOS inhibitor versus norepinephrine in the treatment of septic shock.

    Science.gov (United States)

    Su, Fuhong; Huang, Hongchuan; Akieda, Kazuki; Occhipinti, Giovanna; Donadello, Katia; Piagnerelli, Michael; De Backer, Daniel; Vincent, Jean-Louis

    2010-09-01

    Inhibition of NOS is not beneficial in septic shock; selective inhibition of the inducible form (iNOS) may represent a better option. We compared the effects of the selective iNOS inhibitor BYK191023 with those of norepinephrine (NE) in a sheep model of septic shock. Twenty-four anesthetized, mechanically ventilated ewes received 1.5 g/kg body weight of feces into the abdominal cavity to induce sepsis. Animals were randomized into three groups (each n = 8): NE-only, BYK-only, and NE + BYK. The sublingual microcirculation was evaluated with sidestream dark-field videomicroscopy. MAP was higher in the NE + BYK group than in the other groups, but there were no significant differences in cardiac index or systemic vascular resistance. Mean pulmonary arterial pressure was lower in BYK-treated animals than in the NE-only group. PaO2/FiO2 was higher and lactate concentration lower in the BYK groups than in the NE-only group. Mesenteric blood flow was higher in BYK groups than in the NE-only group. Renal blood flow was higher in the NE + BYK group than in the other groups. Functional capillary density and proportion of perfused vessels were higher in the BYK groups than in the NE-only group 18 h after induction of peritonitis. Survival times were similar in the three groups. In this model of peritonitis, selective iNOS inhibition had more beneficial effects than NE on pulmonary artery pressures, gas exchange, mesenteric blood flow, microcirculation, and lactate concentration. Combination of this selective iNOS inhibitor with NE allowed a higher arterial pressure and renal blood flow to be maintained.

  11. Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin

    NARCIS (Netherlands)

    Lechner, Matthias; Lirk, Philipp; Rieder, Josef

    2005-01-01

    Inducible nitric oxide synthase (iNOS) is one of three key enzymes generating nitric oxide (NO) from the amino acid l-arginine. iNOS-derived NO plays an important role in numerous physiological (e.g. blood pressure regulation, wound repair and host defence mechanisms) and pathophysiological

  12. Nitric oxide synthase (NOS) in the trigeminal vascular system and other brain structures related to pain in rats

    DEFF Research Database (Denmark)

    Ramachandran, Roshni; Ploug, Kenneth Beri; Hay-Schmidt, Anders

    2010-01-01

    to measure the respective levels of mRNA and protein for nNOS and eNOS in peripheral and central tissues involved in migraine pain: dura mater, pial arteries, trigeminal ganglion (TG) trigeminal nucleus caudalis (TNC), periaqueductal grey (PAG), thalamus, hypothalamus, cortex, pituitary gland, hippocampus...... and cerebellum. iNOS was excluded from the present study because it was not induced. In the trigeminal vascular system we found the highest expression of nNOS mRNA in pial arteries. However, protein expression of nNOS was maximum in TNC. Among other brain structures, nNOS mRNA and protein expression...... was remarkably higher in the cerebellum than in any other tissues. Regarding eNOS in the trigeminovascular system, the highest mRNA expression was found in pial arteries. In the other brain structures, eNOS mRNA expression was similar but with lowest mRNA concentration in the pituitary gland and the highest...

  13. ONE PROBABLE MECHANISM OF THE LEARNING-MEMORY DAMAGE BY LEAD: THE CHANGES OF NOS IN HIPPOCAMPUS

    Institute of Scientific and Technical Information of China (English)

    王静; 赵义; 杨章民; 张进; 李积胜; 司履生; 王一理

    2003-01-01

    Objective To study the effects of lead on the activity and expression of nitric oxide synthase (NOS) and relationship between the effects of lead on learning-memory and changes of NOS in subfields of hippocampus. Methods Y-maze test was used to study the effects of lead on ability of learning-memory; NADPH-d histochemistry and immunohistochemistry methods were used to investigate the changes of NOS in subfields of hippocampus. Results Compared with the control group, the ability of learning- memory in lead-exposed rats was significantly decreased (P<0.05); the number of NOS positive neurons in CA1 region and dentate gyrus of lead-exposed rats was significantly decreased(P<0.05), but no marked changes in CA3 region; the number of nNOS positive neurons in CA1 of lead-exposed rats was also significantly decreased(P<0.05), but no obvious changes in CA3. Conclusion Lead could damage the ability of learning-memory in rats. Lead could decrease the activity and expression of NOS in hippocampus and had different effects on NOS in different subfields of hippocampus. The changes of NOS in hippocampus induced by lead may be the mechanism of the learning-memory damage by lead.

  14. 76 FR 1469 - Calvert Cliffs Nuclear Power Plant, LLC; Calvert Cliffs Nuclear Power Plant, Unit Nos. 1 and 2...

    Science.gov (United States)

    2011-01-10

    ... Nuclear Power Plant, LLC; Calvert Cliffs Nuclear Power Plant, Unit Nos. 1 and 2 Environmental Assessment... Plant, LLC, the licensee, for operation of the Calvert Cliffs Nuclear Power Plant, Unit Nos. 1 and 2... Impact Statement for License Renewal of Nuclear Plants, Calvert Cliffs Nuclear Power Plant (NUREG-1437...

  15. 75 FR 66802 - Calvert Cliffs Nuclear Power Plant, LLC; Calvert Cliffs Nuclear Power Plant, Unit Nos. 1 and 2...

    Science.gov (United States)

    2010-10-29

    ... Nuclear Power Plant, LLC; Calvert Cliffs Nuclear Power Plant, Unit Nos. 1 and 2; Notice of Withdrawal of...) has granted the request of Calvert Cliffs Nuclear Power Plant, LLC, the licensee, to withdraw its... for the Calvert Cliffs Nuclear Power Plant, Unit Nos. 1 and 2, located in Calvert County, MD. The...

  16. 75 FR 6223 - PSEG Nuclear LLC; Hope Creek Generating Station and Salem Nuclear Generating Station, Unit Nos. 1...

    Science.gov (United States)

    2010-02-08

    ... NUCLEAR REGULATORY COMMISSION [Docket Nos. 50-272, 50-311 and 50-354; NRC-2010-0043] PSEG Nuclear LLC; Hope Creek Generating Station and Salem Nuclear Generating Station, Unit Nos. 1 and 2...-70, and DPR-75, issued to PSEG Nuclear LLC (PSEG, the licensee), for operation of the Hope Creek...

  17. Common Variation in the NOS1AP Gene Is Associated With Drug-Induced QT Prolongation and Ventricular Arrhythmia

    NARCIS (Netherlands)

    Jamshidi, Yalda; Nolte, Ilja M.; Dalageorgou, Chrysoula; Zheng, Dongling; Johnson, Toby; Bastiaenen, Rachel; Ruddy, Suzanne; Talbott, Daniel; Norris, Kris J.; Snieder, Harold; George, Alfred L.; Marshall, Vanessa; Shakir, Saad; Kannankeril, Prince J.; Munroe, Patricia B.; Camm, A. John; Jeffery, Steve; Roden, Dan M.; Behr, Elijah R.

    2012-01-01

    Objectives This study sought to determine whether variations in NOS1AP affect drug-induced long QT syndrome (LQTS). Background Use of antiarrhythmic drugs is limited by the high incidence of serious adverse events including QT prolongation and torsades de pointes. NOS1AP gene variants play a role in

  18. Exposure to diesel exhaust up-regulates iNOS expression in ApoE knockout mice

    International Nuclear Information System (INIS)

    Bai Ni; Kido, Takashi; Kavanagh, Terrance J.; Kaufman, Joel D.; Rosenfeld, Michael E.; Breemen, Cornelis van; Eeden, Stephan F. van

    2011-01-01

    Traffic related particulate matter air pollution is a risk factor for cardiovascular events; however, the biological mechanisms are unclear. We hypothesize that diesel exhaust (DE) inhalation induces up-regulation of inducible nitric oxide synthase (iNOS), which is known to contribute to vascular dysfunction, progression of atherosclerosis and ultimately cardiovascular morbidity and mortality. Methods: ApoE knockout mice (30-week) were exposed to DE (at 200 μg/m 3 of particulate matter) or filtered-air (control) for 7 weeks (6 h/day, 5 days/week). iNOS expression in the blood vessels and heart was evaluated by immunohistochemistry and western blotting analysis. To examine iNOS activity, thoracic aortae were mounted in a wire myograph, and vasoconstriction stimulated by phenylephrine (PE) was measured with and without the presence of the specific inhibitor for iNOS (1400 W). NF-κB (p65) activity was examined by ELISA. The mRNA expression of iNOS and NF-κB (p65) was determined by real-time PCR. Results: DE exposure significantly enhanced iNOS expression in the thoracic aorta (4-fold) and heart (1.5 fold). DE exposure significantly attenuated PE-stimulated vasoconstriction by ∼ 20%, which was partly reversed by 1400 W. The mRNA expression of iNOS and NF-κB was significantly augmented after DE exposure. NF-κB activity was enhanced 2-fold after DE inhalation, and the augmented NF-κB activity was positively correlated with iNOS expression (R 2 = 0.5998). Conclusions: We show that exposure to DE increases iNOS expression and activity possibly via NF-κB-mediated pathway. We suspect that DE exposure-caused up-regulation of iNOS contributes to vascular dysfunction and atherogenesis, which could ultimately lead to urban air pollution-associated cardiovascular morbidity and mortality. - Highlights: → Exposed ApoE knockout mice (30-week) to diesel exhaust (DE) for 7 weeks. → Examine iNOS expression and activity in the blood vessels and heart. → DE exposure

  19. Changes and significance of TNF - α, NOS activity and NO in the plasma of patients with chronic congestive heart failure

    International Nuclear Information System (INIS)

    Zhou Yafeng; Cheng Xujie; Liu Zhihua

    2003-01-01

    Objective: To study changes and interrelations of TNF - α, NOS activity and NO in the plasma of patients with chronic congestive heart failure (CHF). Methods: The blood samples were taken from eighty patients and twenty healthy subjects. Plasma TNF - α was measured by RIA. Plasma NOS activity and NO were assessed with colorimetric analysis. Results: The level of plasma TNF - α, NOS activity and NO were significantly higher in CHF patients than that in healthy subjects and were increased with the severity of heart failure. The levels of TNF - α, NOS activity and NO showed significant relation with each other and all of them were closely related to the ejection fraction. Conclusion: TNF - α, NOS activity and NO increase greatly in patients of CHF and they maybe play an important roles in the progress of CHF. They can be used as markers for the severity and prognosis of heart failure

  20. Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice

    International Nuclear Information System (INIS)

    Xu, Qin; Zhu, Zhiwei; Xu, Jialu; Gu, Weizhong; Zhao, Zhengyan

    2012-01-01

    Nitric oxide (NO), synthesized as needed by NO synthase (NOS), is involved in spinogenesis and synaptogenesis. Immature spine morphology is characteristic of fragile X syndrome (FXS). The objective of this research was to investigate and compare changes of postnatal neuronal NOS (nNOS) expression in the hippocampus of male fragile X mental retardation 1 gene knockout mice (FMR1 KO mice, the animal model of FXS) and male wild-type mice (WT) at postnatal day 7 (P7), P14, P21, and P28. nNOS mRNA levels were analyzed by real-time quantitative PCR (N = 4-7) and nNOS protein was estimated by Western blot (N = 3) and immunohistochemistry (N = 1). In the PCR assessment, primers 5′-GTGGCCATCGTGTCCTACCATAC-3′ and 5′-GTTTCGAGGCAGGTGGAAGCTA-3′ were used for the detection of nNOS and primers 5′-CCGTTTCTCCTGGCTCAGTTTA-3′ and 5′-CCCCAATACCACATCATCCAT-3′ were used for the detection of β-actin. Compared to the WT group, nNOS mRNA expression was significantly decreased in FMR1 KO mice at P21 (KO: 0.2857 ± 0.0150, WT: 0.5646 ± 0.0657; P < 0.05). Consistently, nNOS immunoreactivity also revealed reduced staining intensity at P21 in the FMR1 KO group. Western blot analysis validated the immunostaining results by demonstrating a significant reduction in nNOS protein levels in the FMR1 KO group compared to the WT group at P21 (KO: 0.3015 ± 0.0897, WT: 1.7542 ± 0.5455; P < 0.05). These results suggest that nNOS was involved in the postnatal development of the hippocampus in FXS and impaired NO production may retard spine maturation in FXS

  1. Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Qin; Zhu, Zhiwei; Xu, Jialu [Department of Children' s Health Care, Children' s Hospital, Zhejiang University, Hangzhou Zhejiang (China); Gu, Weizhong [Department of Pathology, Children' s Hospital, Zhejiang University, Hangzhou Zhejiang (China); Zhao, Zhengyan [Department of Children' s Health Care, Children' s Hospital, Zhejiang University, Hangzhou Zhejiang (China)

    2012-10-05

    Nitric oxide (NO), synthesized as needed by NO synthase (NOS), is involved in spinogenesis and synaptogenesis. Immature spine morphology is characteristic of fragile X syndrome (FXS). The objective of this research was to investigate and compare changes of postnatal neuronal NOS (nNOS) expression in the hippocampus of male fragile X mental retardation 1 gene knockout mice (FMR1 KO mice, the animal model of FXS) and male wild-type mice (WT) at postnatal day 7 (P7), P14, P21, and P28. nNOS mRNA levels were analyzed by real-time quantitative PCR (N = 4-7) and nNOS protein was estimated by Western blot (N = 3) and immunohistochemistry (N = 1). In the PCR assessment, primers 5′-GTGGCCATCGTGTCCTACCATAC-3′ and 5′-GTTTCGAGGCAGGTGGAAGCTA-3′ were used for the detection of nNOS and primers 5′-CCGTTTCTCCTGGCTCAGTTTA-3′ and 5′-CCCCAATACCACATCATCCAT-3′ were used for the detection of β-actin. Compared to the WT group, nNOS mRNA expression was significantly decreased in FMR1 KO mice at P21 (KO: 0.2857 ± 0.0150, WT: 0.5646 ± 0.0657; P < 0.05). Consistently, nNOS immunoreactivity also revealed reduced staining intensity at P21 in the FMR1 KO group. Western blot analysis validated the immunostaining results by demonstrating a significant reduction in nNOS protein levels in the FMR1 KO group compared to the WT group at P21 (KO: 0.3015 ± 0.0897, WT: 1.7542 ± 0.5455; P < 0.05). These results suggest that nNOS was involved in the postnatal development of the hippocampus in FXS and impaired NO production may retard spine maturation in FXS.

  2. Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice

    Directory of Open Access Journals (Sweden)

    Qin Xu

    2012-12-01

    Full Text Available Nitric oxide (NO, synthesized as needed by NO synthase (NOS, is involved in spinogenesis and synaptogenesis. Immature spine morphology is characteristic of fragile X syndrome (FXS. The objective of this research was to investigate and compare changes of postnatal neuronal NOS (nNOS expression in the hippocampus of male fragile X mental retardation 1 gene knockout mice (FMR1 KO mice, the animal model of FXS and male wild-type mice (WT at postnatal day 7 (P7, P14, P21, and P28. nNOS mRNA levels were analyzed by real-time quantitative PCR (N = 4-7 and nNOS protein was estimated by Western blot (N = 3 and immunohistochemistry (N = 1. In the PCR assessment, primers 5’-GTGGCCATCGTGTCCTACCATAC-3’ and 5’-GTTTCGAGGCAGGTGGAAGCTA-3’ were used for the detection of nNOS and primers 5’-CCGTTTCTCCTGGCTCAGTTTA-3’ and 5’-CCCCAATACCACATCATCCAT-3’ were used for the detection of β-actin. Compared to the WT group, nNOS mRNA expression was significantly decreased in FMR1 KO mice at P21 (KO: 0.2857 ± 0.0150, WT: 0.5646 ± 0.0657; P < 0.05. Consistently, nNOS immunoreactivity also revealed reduced staining intensity at P21 in the FMR1 KO group. Western blot analysis validated the immunostaining results by demonstrating a significant reduction in nNOS protein levels in the FMR1 KO group compared to the WT group at P21 (KO: 0.3015 ± 0.0897, WT: 1.7542 ± 0.5455; P < 0.05. These results suggest that nNOS was involved in the postnatal development of the hippocampus in FXS and impaired NO production may retard spine maturation in FXS.

  3. Parliament representation in Latin America. The permanent commissions and the parties in Congress La representación parlamentaria en América latina. Las comisiones permanentes y los partidos en el congreso

    Directory of Open Access Journals (Sweden)

    Luisa BÉJAR

    2009-04-01

    delegación de corte muy diverso. En este escrito se revisa el acomodo institucional del sistema de comisiones de la Cámara Baja en: Argentina; Bolivia; Brasil; Colombia; Chile; México; Paraguay; República Dominicana y Uruguay. En este sentido, el estudio examina tanto la importancia concedida a su trabajo, como algunos aspectos de su morfología que afectan la estructura de incentivos que acota el desarrollo del proceso legislativo. Asimismo, se analizan los procedimientos utilizados en cada Congreso para enfrentar los problemas de acción colectiva. Por último, se presentan algunas ideas para la elaboración de una futura taxonomía sobre la relación que guardan en la región los partidos y las comisiones permanentes del Congreso.ABSTRACT: The main argument of this paper is that the heterogeneity of the institutional framework that prevails in Latin America’s electoral field (Carroll y Shugart, 2005, also reproduces itself in the parliamentary one. This is proved by the morphologic profile of each Congress’ commission system and the place that the law assigns to the system. While some legislative frameworks clearly intend to delegate to parties the decisions entrusted to this bodies; in other cases, this takes place in a less important way. In the cases formally related with a party logic, on the other hand, diverse delegation schemes are encouraged. In this article we analyze the institutional framework of the commission systems of the low chamber in: Argentina; Bolivia; Brazil; Colombia; Chile; Mexico; Paraguay; Dominican Republic and Uruguay. In this sense, this work examines the importance given to their job and some aspects of its morphology that affect the structure of incentives that narrows the development of the legislative process. We also analyze the procedures used by each Congress to solve its problems of collective action. Lastly, some ideas for the elaboration of a future taxonomy on the relationship between parties and permanent commissions in

  4. A Teoria Fundamentada nos Dados nos estudos de Pós-Graduação Stricto Sensu da Enfermagem brasileira

    Directory of Open Access Journals (Sweden)

    Marcelle Miranda da Silva

    2011-12-01

    Full Text Available Estudo documental e quantitativo, que objetivou identificar as teses e dissertações defendidas nos Programas de Pós- Graduação em Enfermagem do Brasil que utilizaram o referencial metodológico da Teoria Fundamentada nos Dados (TFD e analisar os aspectos epistemológicos destacados. Os dados foram coletados no Banco de Teses da CAPES, no recorte temporal entre 1996 a 2010. Foram levantados 99 resumos. Realizou-se a leitura analítica dos mesmos para constituição do tema ou problema da pesquisa e do enquadramento teórico. O maior número de produção foi em 2005, na soma dos dois níveis acadêmicos, e 54% das defesas foram sediadas na USP. As áreas temáticas mais expressivas foram: Saúde da Criança/Adolescente; Gestão em Saúde/Enfermagem; Saúde Coletiva e Saúde da Mulher. O principal referencial teórico utilizado foi o Interacionismo Simbólico. A TFD compreende uma metodologia que pode ser empregada na enfermagem, capaz de contribuir no desenvolvimento de novas investigações para o seu aprimoramento contínuo.

  5. β-Adrenergic induced SR Ca2+ leak is mediated by an Epac-NOS pathway.

    Science.gov (United States)

    Pereira, Laëtitia; Bare, Dan J; Galice, Samuel; Shannon, Thomas R; Bers, Donald M

    2017-07-01

    Cardiac β-adrenergic receptors (β-AR) and Ca 2+ -Calmodulin dependent protein kinase (CaMKII) regulate both physiological and pathophysiological Ca 2+ signaling. Elevated diastolic Ca 2+ leak from the sarcoplasmic reticulum (SR) contributes to contractile dysfunction in heart failure and to arrhythmogenesis. β-AR activation is known to increase SR Ca 2+ leak via CaMKII-dependent phosphorylation of the ryanodine receptor. Two independent and reportedly parallel pathways have been implicated in this β-AR-CaMKII cascade, one involving exchange protein directly activated by cAMP (Epac2) and another involving nitric oxide synthase 1 (NOS1). Here we tested whether Epac and NOS function in a single series pathway to increase β-AR induced and CaMKII-dependent SR Ca 2+ leak. Leak was measured as both Ca 2+ spark frequency and tetracaine-induced shifts in SR Ca 2+ , in mouse and rabbit ventricular myocytes. Direct Epac activation by 8-CPT (8-(4-chlorophenylthio)-2'-O-methyl-cAMP) mimicked β-AR-induced SR Ca 2+ leak, and both were blocked by NOS inhibition. The same was true for myocyte CaMKII activation (assessed via a FRET-based reporter) and ryanodine receptor phosphorylation. Inhibitor and phosphorylation studies also implicated phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt) downstream of Epac and above NOS activation in this pathway. We conclude that these two independently characterized parallel pathways function mainly via a single series arrangement (β-AR-cAMP-Epac-PI3K-Akt-NOS1-CaMKII) to mediate increased SR Ca 2+ leak. Thus, for β-AR activation the cAMP-PKA branch effects inotropy and lusitropy (by effects on Ca 2+ current and SR Ca 2+ -ATPase), this cAMP-Epac-NOS pathway increases pathological diastolic SR Ca 2+ leak. This pathway distinction may allow novel SR Ca 2+ leak therapeutic targeting in treatment of arrhythmias in heart failure that spare the inotropic and lusitropic effects of the PKA branch. Copyright © 2017 Elsevier Ltd. All

  6. Utilização do Sig na Delimitação das Áreas de Preservação Permanente (APP’s) na Bacia do Rio Sagrado (Morretes/PR) / Use of Gis in the Delimitation of Mandatory Preservation Areas in the Hydrographic Basin of Sagrado River (Morretes/PR)

    OpenAIRE

    Alexei Nowatzki; Leonardo José Cordeiro Santos; Eduardo Vedor de Paula

    2010-01-01

    O presente trabalho se enquadra no Programa CAD (Contaminantes, Assoreamento e Dragagem) no Estuário de Paranaguá/PR, tendo por objetivo a utilização do SIG (Sistema de Informações Geográficas) para a delimitação das Áreas de Preservação Permanente (APP's), na bacia hidrográfica do Rio Sagrado (Morretes/PR). Como etapa preliminar efetuou-se o estudo da legislação brasileira vigente (Código Florestal e resoluções CONAMA) no que se refere à delimitação das APP's. Em seguida, por meio do softwar...

  7. Irrompimento do primeiro molar permanente em crianças de 5 e 6 anos de idade: implicações da análise longitudinal para prevenção da cárie oclusal Emergence of the first permanent molar in 5-6-year-old children: implications from a longitudinal analysis for occlusal caries prevention

    Directory of Open Access Journals (Sweden)

    Paulo Frazão

    2011-06-01

    Full Text Available O tempo de irrompimento dentário é essencial para o planejamento de medidas de prevenção da cárie oclusal. Com a ampliação do ensino fundamental de oito para nove anos de duração, um número maior de crianças entre cinco e seis anos de idade é incluído na primeira série do ensino fundamental. OBJETIVO: O objetivo foi estimar as tendências do irrompimento dos primeiros molares permanentes em meninos e meninas de 5 e 6 anos de idade. MÉTODOS: Em estudo longitudinal, espaços dentários de 497 crianças de 60 meses e mais de idade foram examinados quatro vezes por um dentista calibrado (kappa > 0,97 durante 18 meses. O primeiro molar permanente foi considerado irrompido quando qualquer parte de sua superfície podia ser tocada por uma sonda de ponta esférica. A idade dos participantes foi medida em meses. Intervalos para 95% de confiança dos valores de prevalência e incidência foram apurados conforme o sexo para três coortes etárias: 60,0 a 65,9; 66,0 a 71,9; 72,0 a 77,9 meses. A razão entre as taxas de incidência foi estimada por meio de análise de regressão de Poisson. RESULTADOS: A maioria das crianças entre 66,0 e 71,9 meses e entre 72,0 e 77,9 meses tem pelo menos um molar permanente irrompido. No grupo de 66,0 a 71,9 meses, de cada três crianças pelo menos uma apresentou os quatro primeiros molares permanentes irrompidos. CONCLUSÃO. As tendências de irrompimento observadas justificam a necessidade da adoção de medidas de vigilância e de proteção específica em relação à lesão de cárie oclusal.The timing of tooth emergence is of considerable importance in the planning of prevention of occlusal caries. OBJECTIVE: The aim was to estimate the trends of emergence of the first permanent molars in girls and boys between 5-6 years of age, since more children are included in the first grade after Brazilian elementary education has been extended from eight to nine years of duration. METHODS: Dental spaces of 497

  8. Inclusión educativa de alumnos con discapacidades graves y permanentes : análisis de un modelo : la Comunidad Valenciana (España = Educational inclusion of students with severe and permanent disabilities : analysis of a model : the Region of Valencia

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    Manuel López-Torrijo

    2014-09-01

    Full Text Available Este artículo analiza la inclusión educativa del alumnado con discapacidades graves y permanentes en la Comunidad Valenciana (España a través de los siguientes indicadores: concepción de las discapacidades graves y permanentes; responsabilidad de la escolarización y prestación de servicios; marco normativo; identificación, valoración y atención temprana; incidencia en la población; modelos y modalidades de escolarización; propuesta curricular; Centros y Unidades Específicos de Educación Especial; recursos personales y materiales; papel de las familias y financiación. Utiliza el método descriptivo en la revisión legislativa, documental, y bibliográfica, así como en el análisis de las fuentes estadísticas. Concluye señalando las mejoras inmediatas aplicables para una inclusión educativa real y de calidad.This article analyzes the educational inclusion of students with severe and permanent disabilities in the Region of Valencia with the following indicators: design of severe and permanent disabilities, regulatory framework, responsibility for providing schooling and services, identification and assessment of deficits, prevalence, proposed curriculum (model and modalities of care, special schools, human and material resources, role of families and funding. It utilizes the descriptive method in the legislative, documental and bibliographic revision, as well as in the analysis of statistical sources. The analysis concludes by pointing out the challenges that must guide future improvements to achieve a true educational equality.

  9. A meta-analysis of eNOS and ACE gene polymorphisms and risk of pre-eclampsia in women.

    Science.gov (United States)

    Shaik, A P; Sultana, A; Bammidi, V K; Sampathirao, K; Jamil, K

    2011-10-01

    A meta-analyses of endothelial nitric oxide synthase (eNOS) and angiotensin-converting enzyme (ACE) gene polymorphisms in pre-eclampsia was performed. We shortlisted 33 studies (17 for ACE; 16 for eNOS gene polymorphisms), of which 29 articles (16 for ACE and 15 for eNOS) were analysed. Overall, 1,620 cases with pre-eclampsia and 2,158 controls were analysed for intron 16 insertion-deletion polymorphism in ACE gene. A total of 1,610 subjects with pre-eclampsia and 2,875 controls were analysed for the Glu298Asp in eNOS gene. Overall, the random-effects odds ratio (OR) with Glu298Asp in eNOS gene was 0.958 (95% confidence intervals, CI 0.747-1.228, p > 0.05), and for the insertion-deletion/ACE polymorphism was 0.987 (95% CI 0.698-1.395, p > 0.05). Significant heterogeneity was observed in the studies that evaluated polymorphisms in ACE (Q value = 55.6; I(2) = 73; p value = 0.000); and eNOS (Q value = 37.2; I(2) = 62.4; p value = 0.001) polymorphisms. No significant risk of pre-eclampsia was observed in both eNOS and ACE genes with these polymorphisms.

  10. Qualitative and quantitative immunohistochemical evaluation of iNOS expression in the spleen of dogs naturally infected with Leishmania chagasi.

    Science.gov (United States)

    dos Santos, Fernando Rocha; Vieira, Paula Melo Abreu; Correa-Oliveira, Rodrigo; Giunchetti, Rodolfo Cordeiro; Carneiro, Claudia Martins; Reis, Alexandre Barbosa; Malaquias, Luiz Cosme Cotta

    2011-06-01

    Nitric oxide (NO), the product of the nitric oxide synthase enzymes has been detected in Leishmania-infected animals. Besides its role on the immunity to infection, the role of NO and the inducible nitric oxide synthase (iNOS) in the pathogenesis of canine visceral leishmaniasis (CVL) is not well understood. This study aimed at evaluating immunohistochemically the iNOS expression in the spleen of dogs naturally infected (ID) with Leishmania (L.) chagasi compared with non-infected dogs (NID). The ID was grouped according to the clinical form and the parasite load. Symptomatic dogs (SD) presented higher parasite load in relation to oligosymptomatic (OD) and asymptomatic (AD). The qualitative expression of iNOS was observed only in ID. SD presented strong and prominent labeling of iNOS, followed by OD and AD. Quantitatively, the results showed that the median expression of iNOS was higher in SD and OD compared to NID. Also, dog spleens with high parasitism load showed marked iNOS expression. Taken together, the results suggest that the expression of iNOS in the spleen of infected dogs with CVL was associated with clinical worsening of the disease and with high parasitism.

  11. Gallic Acid Enriched Fraction of Phyllanthus emblica Potentiates Indomethacin-Induced Gastric Ulcer Healing via e-NOS-Dependent Pathway

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    Ananya Chatterjee

    2012-01-01

    Full Text Available The healing activity of gallic acid enriched ethanolic extract (GAE of Phyllanthus emblica fruits (amla against the indomethacin-induced gastric ulceration in mice was investigated. The activity was correlated with the ability of GAE to alter the cyclooxygenase- (COX- dependent healing pathways. Histology of the stomach tissues revealed maximum ulceration on the 3rd day after indomethacin (18 mg/kg, single dose administration that was associated with significant increase in inflammatory factors, namely, mucosal myeloperoxidase (MPO activity and inducible nitric oxide synthase (i-NOS expression. Proangiogenic parameters such as the levels of prostaglandin (PG E2, vascular endothelial growth factor (VEGF, hepatocyte growth factor (HGF, von Willebrand Factor VIII, and endothelial NOS (e-NOS were downregulated by indomethacin. Treatment with GAE (5 mg/kg/day and omeprazole (3 mg/kg/day for 3 days led to effective healing of the acute ulceration, while GAE could reverse the indomethacin-induced proinflammatory changes of the designated biochemical parameters. The ulcer healing activity of GAE was, however, compromised by coadministration of the nonspecific NOS inhibitor, N-nitro-L-arginine methyl ester (L-NAME, but not the i-NOS-specific inhibitor, L-N6-(1-iminoethyl lysine hydrochloride (L-NIL. Taken together, these results suggested that the GAE treatment accelerates ulcer healing by inducing PGE2 synthesis and augmenting e-NOS/i-NOS ratio.

  12. Science learning based on local potential: Overview of the nature of science (NoS) achieved

    Science.gov (United States)

    Wilujeng, Insih; Zuhdan Kun, P.; Suryadarma, IGP.

    2017-08-01

    The research concerned here examined the effectiveness of science learning conducted with local potential as basis from the point of a review of the NoS (nature of science) achieved. It used the non equivalent control group design and took place in the regions of Magelang and Pati, Province of Central Java, and the regions of Bantul and Sleman, Province of the Special Region of Yogyakarta. The research population consisted of students of the first and second grades at each junior high school chosen with research subjects sampled by means of cluster sampling. The instruments used included: a) an observation sheet, b) a written test, and c) a questionnaire. The learning and research instruments had been declared valid and reliable according to previous developmental research. In conclusion, the science learning based on local potential was effective in terms of all the NoS aspects.

  13. O papel da arte nos centros de atenção psicossocial - CAPS

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    Claudia Mara de Melo Tavares

    2003-02-01

    Full Text Available Estudo sobre o uso da abordagem artística nos cuidados desenvolvidos nos Centros de Atenção Psicossocial (CAPS. Fundamentado em bases conceituais da Reforma Psiquiátrica, o objeto de estudo foi abordado por meio de uma pesquisa exploratória de campo, através da entrevista com profissionais dos CAPS. Os resultados encontrados indicam que atividades de base artística são utilizadas visando a uma interação positiva com o usuário do serviço na perspectiva de sua reabilitação psicossocial. Concluímos que o trabalho no CAPS atualiza a potencialidade criativa dos profissionais e usuários, sendo a arte tomada como uma estratégia de cuidar.

  14. COMPORTAMENTO DOS PREÇOS NOS MERCADOS BRASILEIROS DE SUINOS, MILHO E SOJA

    OpenAIRE

    Rosado, Patricia Lopes; Gomes, Marilia Fernandes Maciel; Figueiredo, Adelson Martins

    2006-01-01

    O comportamento das séries históricas de preços de suínos e dos principais insumos usados no seu processo produtivo como, milho e soja, pode apresentar oscilações que o produtor, geralmente, não consegue prever, o que contribui para elevar o risco da atividade. Destarte, como forma de fornecer subsídios teóricos e empíricos aos agentes econômicos envolvidos em operações com suínos, milho e soja, buscou-se, neste trabalho, detectar a existência dos componentes estocásticos e, ou, determinístic...

  15. A CRISE DO PLANEJAMENTO DE TRANSPORTES NOS PAÍSES EM DESENVOLVIMENTO: REAVALIANDO PRESSUPOSTOS E ALTERNATIVAS

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    Eduardo A. Vasconcellos

    2010-04-01

    Full Text Available O artigo faz inicialmente uma sistematização dos problemas verificados nos países em desenvolvimento, como contribuição ao entendimento da crise urbana e seus efeitos sobre as condições de transporte, são sugeridos novos pressupostos e novos objetivos de orientação do processo de planejamento de transportes.

  16. A RELIGIOSIDADE POPULAR NOS EXERCÍCIOS ESPIRITUAIS DE SANTO INÁCIO DE LOYOLA

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    Victor Codina

    1987-01-01

    Full Text Available Uma primeira impressão frente ao texto e à prática dos Exercícios Espirituais de Santo Inácio (EE nos levaria à conclusão de que os EE se dirigem prioritariamente aos setores não populares da sociedade e da Igreja, e que tanto seu conteúdo como sua estrutura respondem a uma espiritualidade culta e quase elitista.

  17. Fracionamento de manganês acumulado nos tecidos de mudas de caramboleira

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    Amanda Hernandes

    2011-10-01

    Full Text Available A caramboleira (Averrhoa carambola tende a acumular grande quantidade de Mn nos seus tecidos, mas são escassas as informações sobre a forma como o excesso desse nutriente permanece na planta. Com o objetivo de contribuir para o esclarecimento desse aspecto, neste trabalho foram cultivadas mudas de caramboleira em solução nutritiva de Furlani (1999 com concentrações crescentes de Mn (0; 0,5; 25; e 50 mg L-1 de Mn, e aos 30, 60, 90 e 120 dias os tecidos de caule, folha e raiz foram colhidos e submetidos a uma sequência de soluções extratoras: água, DTPA (ácido dietilenotriaminopentacético e HCl (ácido clorídrico 1 mol L-1, com posterior determinação da quantidade de Mn nos extratos e nos tecidos remanescentes. Foram encontrados teores crescentes de Mn nos extratos de água, DTPA e HCl 1 mol L-1. A maior parte (cerca de 50 % do Mn permaneceu no tecido vegetal, mesmo após subsequentes extrações com as diferentes soluções extratoras, indicando que essa parte está fortemente ligada aos tecidos. Os maiores teores de Mn foram encontrados nas raízes e, os menores, no caule e nas folhas, sugerindo que a caramboleira tende a fixar o Mn nas raízes, possivelmente como mecanismo para limitar o transporte para a parte área, evitando a intoxicação da planta.

  18. Cumulative Author Index for Soviet Laser Bibliographies Nos. 67-93, September 1983-February 1989

    Science.gov (United States)

    1990-02-01

    C) 0 00 I: Cumulative Author Index for Soviet Laser Bibliographies September 1983 - February 1989 A Defense S&T Intelligence Special Purpose Document...90 CUMULATIVE AUTHOR INDEX FOR SOVIET LASER BIBLIOGRAPHIES Nos. 67-93 SEPTEMBER 1983 - FEBRUARY 1989 Date of Report March 31, 19 Vice Director for...RECIPIENT’S CATALOG NUMBER DST-2700Z-001-90 4. TITLE (and Subtitle) S. TYPE OF REPORT & PERIOD COVERED CUMULATIVE AUTHOR INDEX FOR SOVIET LASER

  19. Recommendations on AECB draft licensing guides nos. 40,41,42

    International Nuclear Information System (INIS)

    1981-06-01

    This report contains the recommendations of the Advisory Committee on Nuclear Safety (ACNS) to the Atomic Energy Control Board concerning the draft AECB Licensing Guides 40, 41 and 42 which were issued subsequently as Consultative Documents Nos. 7, 8 and 9. Since the report focusses on points of principle or generic concern, most of its recommendations apply generally to all three documents, although some specific recommendations are included [fr

  20. Differential response of nNOS knockout mice to MDMA ("ecstasy")- and methamphetamine-induced psychomotor sensitization and neurotoxicity.

    Science.gov (United States)

    Itzhak, Yossef; Anderson, Karen L; Ali, Syed F

    2004-10-01

    It has been shown that mice deficient in neuronal nitric oxide synthase (nNOS) gene are resistant to cocaine-induced psychomotor sensitization and methamphetamine (METH)-induced dopaminergic neurotoxicity. The present study was undertaken to investigate the hypothesis that nNOS has a major role in dopamine (DA)- but not serotonin (5-hydroxytryptamine; 5-HT)-mediated effects of psychostimulants. The response of nNOS knockout (KO) and wild-type (WT) mice to the psychomotor-stimulating and neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy") and METH were investigated. Repeated administration of MDMA for 5 days resulted in psychomotor sensitization in both WT and nNOS KO mice, while repeated administration of METH caused psychomotor sensitization in WT but not in KO mice. Sensitization to both MDMA and METH was persistent for 40 days in WT mice, but not in nNOS KO mice. These findings suggest that the induction of psychomotor sensitization to MDMA and METH is NO independent and NO dependent, respectively, while the persistence of sensitization to both drugs is NO dependent. For the neurochemical studies, a high dose of MDMA caused marked depletion of 5-HT in several brain regions of both WT and KO mice, suggesting that the absence of the nNOS gene did not afford protection against MDMA-induced depletion of 5-HT. Striatal dopaminergic neurotoxicity caused by high doses of MDMA and METH in WT mice was partially prevented in KO mice administered with MDMA, but it was fully precluded in KO mice administered with METH. The differential response of nNOS KO mice to the behavioral and neurotoxic effects of MDMA and METH suggests that the nNOS gene is required for the expression and persistence of DA-mediated effects of METH and MDMA, while 5-HT-mediated effects of MDMA (induction of sensitization and 5-HT depletion) are not dependent on nNOS.

  1. Diagnosticos de enfermagem em pacientes classificados nos niveis I e II de prioridade do Protocolo Manchester

    Directory of Open Access Journals (Sweden)

    Cristiane Chaves de Souza

    2013-12-01

    Full Text Available O estudo objetivou identificar possíveis diagnósticos de enfermagem em pacientes classificados nos níveis I e II de prioridade do protocolo Manchester. Trata-se de estudo descritivo retrospectivo, cuja amostra foi de 40 prontuários de pacientes classificados nos níveis I e II de prioridade. Para identificação dos diagnósticos de enfermagem dois especialistas analisaram sinais e sintomas registrados nos prontuários dos pacientes no momento da classificação de risco. No nível I de prioridade, os diagnósticos de enfermagem mais frequentes foram: dor aguda (65,0%, padrão respiratório ineficaz (45,0% e troca de gases prejudicada (40,0%. No nível II de prioridade foram: dor aguda (80,0%, náusea (10,0% e risco de desequilíbrio eletrolítico (10,0%. Percebeu-se que a utilização do protocolo de Manchester favorece a identificação de características definidoras e fatores relacionados/fatores de risco que subsidiam a elaboração de diagnósticos de enfermagem na classificação de risco.

  2. Acetylcholine and bradykinin trigger preconditioning in the heart through a pathway that includes Akt and NOS.

    Science.gov (United States)

    Krieg, Thomas; Qin, Qining; Philipp, Sebastian; Alexeyev, Mikhail F; Cohen, Michael V; Downey, James M

    2004-12-01

    In the rabbit heart, bradykinin and ACh trigger preconditioning by a mechanism involving ATP-sensitive potassium channel-dependent production of reactive oxygen species (ROS). Recent evidence indicates that the pathway by which bradykinin causes ROS generation includes nitric oxide synthase (NOS) and protein kinase G (PKG). On the other hand, Akt was shown to be essential for ACh to generate ROS. This study determines whether these two G-coupled receptor agonists indeed have similar signaling targets, i.e., whether Akt is involved in bradykinin's pathway and whether NOS is involved in ACh's pathway. Isolated adult rabbit cardiomyocytes were incubated for 15 min in reduced MitoTracker red, which becomes fluorescent only after exposure to ROS. Bradykinin (400 nM) and ACh (250 microM) caused a 51.4 +/- 14.8% and 39.8 +/- 11.7% increase, respectively, in ROS production (P hydrochloride (L-NIO, 5 microM). L-NIO also blocked the anti-infarct effect of ACh (550 microM) in isolated rabbit hearts exposed to 30 min of regional ischemia. We conclude that both bradykinin and ACh trigger ROS generation by sequentially activating Akt and NOS.

  3. Anemia nos pacientes com insuficiência cardíaca avançada

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    Juliano Cardoso

    2010-10-01

    Full Text Available FUNDAMENTO: Anemia está associada à pior evolução nos pacientes com insuficiência cardíaca (IC. Entretanto, há poucos estudos sobre a anemia nos pacientes com IC avançada. OBJETIVO: Avaliar as características da anemia na IC em fase avançada. MÉTODOS: Foram incluídos 99 pacientes hospitalizados para compensação de IC (CF IV/NYHA, com idade > 18 anos e FEVE 12 g/dl. A anemia foi marcador independente de mau prognóstico na análise multivariada (mortalidade 47% vs 24,6%, p = 0,016, risco relativo 2,54. CONCLUSÃO: Anemia acomete, aproximadamente, 1/3 dos pacientes com IC avançada, e a deficiência de ferro é uma importante etiologia. Pacientes anêmicos são mais idosos e apresentaram função renal mais deteriorada. A melhora da congestão não foi suficiente para melhorar a anemia na maioria dos casos. Nos pacientes com IC avançada, a anemia é marcador independente de mau prognóstico.

  4. Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North China

    Directory of Open Access Journals (Sweden)

    Yingjie Dai

    2013-01-01

    Full Text Available Nitric oxide (NO is an important messenger molecule and effector molecule. This study aimed to investigate the relation of neuronal nitric oxide synthase (nNOS gene polymorphism with ischemic stroke in Han Chinese of North China. This was a case-control study. A total of 413 patients with ischemic stroke were recruited from Han Chinese of North China. There were 201 males and 212 females. In addition, 477 healthy subjects served as controls including 224 males and 253 females. Multiplex SNaPshot was employed to detect nNOS gene polymorphism (rs2293050, rs2139733, rs7308402, and rs1483757. Results showed that the rs1483757, rs2139733, and rs2293050 genotypes and allele frequencies were comparable between patients and controls. However, ischemic stroke patients had significantly reduced AG genotype and A allele frequency when compared with controls (P=0.037, P=0.041. After adjusting confounding factors (gender, age, smoking, history of drinking, hypertension, and diabetes, AG genotype and A allele were still related to ischemic stroke (OR=0.572, 95% CI: 0.335–0.978, P=0.041; OR=0.611, 95% C: 0.378–0.985, and P=0.041 and both were found to be protective factors. Our results showed that rs7308402 gene polymorphism of nNOS is related to ischemic stroke in Han Chinese of North China.

  5. Association of NOS3 gene variants and clinical contributors of hypoxic-ischemic encephalopathy

    Energy Technology Data Exchange (ETDEWEB)

    Kuzmanić Šamija, R. [Department of Pediatrics, University Hospital Split, Split (Croatia); Primorac, D. [School of Medicine Split, University of Split, Split (Croatia); Department of Pediatrics, School of Medicine, University of Osijek, Osijek (Croatia); Eberly College of Science, Penn State University, University Park, PA (United States); St. Catherine Speciality Hospital, Zabok (Croatia); Rešić, B. [School of Medicine Split, University of Split, Split (Croatia); Pavlov, V. [Department of Neonatology, University Hospital Split, Split (Croatia); Čapkun, V. [Department of Nuclear Medicine, University Hospital Split, Split (Croatia); Punda, H. [School of Medicine Split, University of Split, Split (Croatia); Lozić, B. [Department of Pediatrics, University Hospital Split, Split (Croatia); Zemunik, T. [Department of Medical Biology, School of Medicine Split, University of Split, Split (Croatia)

    2014-08-15

    The aim of this study was to analyze the association of different clinical contributors of hypoxic-ischemic encephalopathy with NOS3 gene polymorphisms. A total of 110 children with hypoxic-ischemic encephalopathy and 128 control children were selected for this study. Association of gender, gestational age, birth weight, Apgar score, cranial ultrasonography, and magnetic resonance imaging findings with genotypic data of six haplotype-tagging single nucleotide polymorphisms and the most commonly investigated rs1800779 and rs2070744 polymorphisms was analyzed. The TGT haplotype of rs1800783, rs1800779, and rs2070744 polymorphisms was associated with hypoxic-ischemic encephalopathy. Children with the TGT haplotype were infants below 32 weeks of gestation and they had the most severe brain damage. Increased incidence of the TT genotype of the NOS3 rs1808593 SNP was found in the group of hypoxic-ischemic encephalopathy patients with medium and severe brain damage. The probability of brain damage was twice as high in children with the TT genotype than in children with the TG genotype of the same polymorphism. Furthermore, the T allele of the same polymorphism was twice as frequent in children with lower Apgar scores. This study strongly suggests associations of NOS3 gene polymorphism with intensity of brain damage and severity of the clinical picture in affected children.

  6. Música da Borda d'Água: nos textos e imagens de Alves Redol

    Directory of Open Access Journals (Sweden)

    Domingos Morais

    2013-01-01

    Full Text Available António Alves Redol, escritor português natural de Vila Franca de Xira, nasceu a 29 de dezembro de 1911 e faleceu a 29 de novembro de 1969. Figura central do Neorrealismo português, foi autor de uma vasta obra ficcional, que inclui o teatro e o conto. Na noite de 25 de outubro de 1940, no Sport Lisboa e Vila Franca, realizou uma palestra sobre a "Música da Borda d'Água" de que não há registo conhecido. Tentamos refazer essa palestra, ou pelo menos as linhas orientadoras do seu discurso, recorrendo a textos de Redol, alguns inéditos, dos anos de 1938 e 1939, que nos foi possível consultar e digitalizar nos acervos do seu filho, António Mota Redol, em outubro de 2012. Na obra de Redol, as referências à música e dança são estruturantes das situações que descreve. Sem entrar em detalhes técnicos que talvez ignorasse, o que nos diz é revelador de como o movimento neorrealista, que tem em Fernando Lopes-Graça um solitário mentor, não descurou os repertórios e cancioneiros populares, contrapondo-os às práticas e gostos musicais das classes dominantes.

  7. Association of NOS3 gene variants and clinical contributors of hypoxic-ischemic encephalopathy

    International Nuclear Information System (INIS)

    Kuzmanić Šamija, R.; Primorac, D.; Rešić, B.; Pavlov, V.; Čapkun, V.; Punda, H.; Lozić, B.; Zemunik, T.

    2014-01-01

    The aim of this study was to analyze the association of different clinical contributors of hypoxic-ischemic encephalopathy with NOS3 gene polymorphisms. A total of 110 children with hypoxic-ischemic encephalopathy and 128 control children were selected for this study. Association of gender, gestational age, birth weight, Apgar score, cranial ultrasonography, and magnetic resonance imaging findings with genotypic data of six haplotype-tagging single nucleotide polymorphisms and the most commonly investigated rs1800779 and rs2070744 polymorphisms was analyzed. The TGT haplotype of rs1800783, rs1800779, and rs2070744 polymorphisms was associated with hypoxic-ischemic encephalopathy. Children with the TGT haplotype were infants below 32 weeks of gestation and they had the most severe brain damage. Increased incidence of the TT genotype of the NOS3 rs1808593 SNP was found in the group of hypoxic-ischemic encephalopathy patients with medium and severe brain damage. The probability of brain damage was twice as high in children with the TT genotype than in children with the TG genotype of the same polymorphism. Furthermore, the T allele of the same polymorphism was twice as frequent in children with lower Apgar scores. This study strongly suggests associations of NOS3 gene polymorphism with intensity of brain damage and severity of the clinical picture in affected children

  8. Mormo em eqüídeos nos Estados de Pernambuco e Alagoas

    Directory of Open Access Journals (Sweden)

    Mota Rinaldo A.

    2000-01-01

    Full Text Available Com base em aspectos clínico-patológicos, epidemiológicos e sorológicos, bem como pelo isolamento de Burkholderia mallei, diagnosticaram-se focos de mormo em eqüídeos na Zona da Mata dos Estados de Pernambuco e Alagoas. Clinicamente observaram-se hipertermia, respiração ruidosa, inapetência, emagrecimento progressivo até caquexia, congestão nasal e descarga mucopurulenta, erosões, úlceras e cicatrizes na mucosa nasal. Os linfonodos mandibulares e cervicais superficiais apresentavam-se aumentados de volume, com abscessos e fístulas exsudando material purulento. Na pele, ao longo dos vasos linfáticos, havia formação de nódulos firmes e abscessos que, nos casos crônicos, fistulavam e ulceravam deixando cicatrizes estrelares. A histopatologia dos nódulos de diversos sítios, tanto dos eqüídeos como dos cobaios utilizados na prova de Straus, revelou lesões granulomatosas e piogranulomas. Os dados deste estudo evidenciam a emergência da doença nesta área e permitem recomendar inquéritos soro-epidemiológicos nos Estados de ocorrência dos surtos e nos Estados limítrofes.

  9. PEDAGOGIA NOS CURSOS DE PEDAGOGIA? da ausência e dos impactos no trabalho pedagógico

    OpenAIRE

    Liliana Soares Ferreira

    2017-01-01

    Esse artigo sistematiza pesquisa realizada nos últimos cinco anos, com o objetivo de estudar os movimentos de sentidos, a historicidade e o trabalho de pedagogas(os) (e, portanto, trabalho pedagógico) descritos nos projetos pedagógicos dos cursos de Pedagogia gaúchos. Com base nesse estudo inicial, objetivou-se entender qual concepção de Pedagogia e de trabalho pedagógico das futuras(os) pedagogas(os) estão na base da elaboração desses projetos pedagógicos e nos discursos de gestores desses c...

  10. KONSUMSI MIKRONUTRIEN DAN EKSPRESI GEN eNOS3 ALEL INTRO 4a4b PADA PENDERITA HIPERTENSI ETNIK MINANGKABAU

    Directory of Open Access Journals (Sweden)

    Delmi Sulastri

    2011-05-01

    Full Text Available AbstrakGen eNOS3 varian intron 4a4b merupakan salah satu gen yang berhubungan dengan kejadian hipertensi esensial. Kemampuan Gen eNOS3 varian ini untuk mensintesis enzim nitric oxide synthase (NOS berkurang sehingga sintesis Nitric oxide (NO menurun. Senyawa NO adalah suatu senyawa vasoaktif yang menyebabkan vasodilatasi pembuluh darah.Penelitian pada subjek hipertensi dan normotensi berusia 30-65 tahun bertujuan untuk melihat pengaruh mikronutrien terhadap ekspresi gen eNOS3 alel intron 4a4b. 130 subjek, diwawancara pola makannya lalu dilakukan analisis asupan mikronutrien, gen eNOS3, serta kadar NO plasma. Data yang diperoleh dianalisis menggunakan uji T dan chi-square.Kadar NO plasma penderita hipertensi adalah 26.91 + 15.40 μM/L dan normotensi 25.79 + 15.04 μM/L. 55.5% subjek hipertensi memiliki gen eNOS3 varian intron 4b dan 69% subjek normotensi mempunyai varian intron 4a4b. Kadar NO plasma rendah, (66.7% ditemukan pada subjek hipertensi dengan varian intron 4b. Tidak terdapat hubungan bermakna asupan mikronutrien dengan kadar NO plasma pada subjek hipertensi.Hasil ini tidak mendukung pengaruh konsumsi mikronutrien terhadap kadar NO plasma pada penderita hipertensi dengan gen eNOS3 varian intron 4a4b.Kata Kunci : hipertensi esensial, gen eNOS3, kadar NO plasmaAbstracteNOS 3 gene intron 4a4b allel is one of the important genes which is related to hypertesion essensial. This gene expresses the nitric oxide synthase (NOS enzyme which regulates the synthesis of Nitric oxide (NO in human body. NO causes vasodilatation, which decreases peripheral resistant and blood pressure.A research has been done based on cross sectional study on hypertension patients and those with normal blood pressure in the range of 30-65 years old. The main of this research is to evaluate the influence of micronutrient consumption on eNOS3 gene intron 4a4b allel expression in hypertension subjects in Minangkabau ethnicity. 130 subjects interviewed about micronutrient

  11. The NF-κB p65 and p50 homodimer cooperate with IRF8 to activate iNOS transcription

    International Nuclear Information System (INIS)

    Simon, Priscilla S.; Sharman, Sarah K.; Lu, Chunwan; Yang, Dafeng; Paschall, Amy V.; Tulachan, Sidhartha S.; Liu, Kebin

    2015-01-01

    Inducible nitric oxide synthase (iNOS) metabolizes L-arginine to produce nitric oxide (NO) which was originally identified in myeloid cells as a host defense mechanism against pathogens. Recent studies, however, have revealed that iNOS is often induced in tumor cells and myeloid cells in the tumor microenvironment. Compelling experimental data have shown that iNOS promotes tumor development in certain cellular context and suppresses tumor development in other cellular conditions. The molecular mechanisms underlying these contrasting functions of iNOS is unknown. Because iNOS is often induced by inflammatory signals, it is therefore likely that these contrasting functions of iNOS could be controlled by the inflammatory signaling pathways, which remains to be determined. iNOS is expressed in colon carcinoma and myeloid cells in the tumor microenvironment. Colon carcinoma and myeloid cell lines were used to elucidate the molecular mechanisms underlying iNOS expression. Chromatin immunoprecipitation and electrophoretic mobility shift assay were used to determine the IFNγ-activated pSTAT1 and NF-κB association with the chromatin DNA of the nos2 promoter. We show here that iNOS is dramatically up-regulated in inflammed human colon tissues and in human colon carcinoma as compared to normal colon tissue. iNOS is expressed in either the colon carcinoma cells or immune cells within the tumor microenvironment. On the molecular level, the proinflammatory IFNγ and NF-κB signals induce iNOS expression in human colon cancer cells. We further demonstrate that NF-κB directly binds to the NOS2 promoter to regulate iNOS expression. Although neither the IFNγ signaling pathway nor the NF-κB signaling pathway alone is sufficient to induce iNOS expression in myeloid cells, IFNγ and NF-κB synergistically induce iNOS expression in myeloid cells. Furthermore, we determine that IFNγ up-regulates IRF8 expression to augment NF-κB induction of iNOS expression. More interestingly, we

  12. Elementary school science teachers' reflection for nature of science: Workshop of NOS explicit and reflective on force and motion learning activity

    Science.gov (United States)

    Patho, Khanittha; Yuenyong, Chokchai; Chamrat, Suthida

    2018-01-01

    The nature of science has been part of Thailand's science education curriculum since 2008. However, teachers lack of understanding about the nature of science (NOS) and its teaching, particularly element school science teachers. In 2012, the Science Institute of Thailand MOE, started a project of Elementary Science Teacher Professional Development to enhance their thinking about the Nature of Science. The project aimed to enhance teachers' understanding of NOS, science teaching for explicit and reflective NOS, with the aim of extending their understanding of NOS to other teachers. This project selected 366 educational persons. The group was made up of a teacher and a teacher supervisor from 183 educational areas in 74 provinces all Thailand. The project provided a one week workshop and a year's follow up. The week-long workshop consisted of 11 activities of science teaching for explicit reflection on 8 aspects of NOS. Workshop of NOS explicit and reflective on force and motion learning activity is one of eight activities. This activity provided participants to learn force and motion and NOS from the traditional toy "Bang-Poh". The activity tried to enhance participants to explicit NOS for 5 aspects including empirical basis, subjectivity, creativity, observation and inference, and sociocultural embeddedness. The explicit NOS worksheet provided questions to ask participants to reflect their existing ideas about NOS. The paper examines elementary school science teachers' understanding of NOS from the force and motion learning activity which provided explicit reflection on 5 NOS aspects. An interpretive paradigm was used to analyse the teachers' reflections in a NOS worksheet. The findings indicated that majority of them could reflect about the empirical basis of science and creativity but few reflected on observation and inference, or sociocultural embeddedness. The paper will explain the teachers' NOS thinking and discuss the further enhancing of their understanding

  13. Influência da competição catiônica nos valores de fator de retardamento e coeficiente de dispersão-difusão de zinco e cobre no solo Effect of the cationic competition on the retarding factor and dispersion-diffusion coefficient of zinc and copper in soil

    Directory of Open Access Journals (Sweden)

    Mauro A. Martinez

    2001-05-01

    Full Text Available Objetivando-se avaliar os efeitos da competição catiônica nos valores do fator de retardamento (f r e do coeficiente de dispersão-difusão (D realizaram-se ensaios de mobilidade de metais em colunas de lixiviação submetidas a escoamento permanente e saturado. Foram aplicadas soluções de zinco (700 mg L-1, cobre (200 mg L-1 e de zinco mais cobre, nas mesmas concentrações, para obtenção das respectivas curvas de eluição. Os materiais de solo utilizados foram retirados dos horizontes A, B e C de um Latossolo Vermelho-Amarelo, álico (LVa e de um Podzólico Vermelho-Amarelo, câmbico fase terraço (PVc coletados no município de Viçosa, MG. Nos solos estudados em todos os horizontes, o cobre apresentou maiores valores de fator de retardamento que o zinco, indicando apresentar maior interação com a fração sólida do solo. As baixas velocidades de avanço das soluções proporcionaram a obtenção de baixos valores de coeficiente de dispersão-difusão no solo e a competição catiônica diminuiu a capacidade de retenção dos cátions no solo.The effects of the cationic competition on the retarding factor (fr and the dispersion-diffusion coefficient (D were evaluated with conducting metal mobility trials in leaching columns submitted to a saturated and steady flow. Solutions of zinc (700 mg L-1, copper (200 mg L-1 and zinc plus copper in the same concentrations, were used to obtain elution curves. Soil materials from the A, B and C horizons of Oxisol (LVa and of Ultisol (PVc, collected in Viçosa, MG, were used. In all soil materials used, copper presented higher retarding factor values than zinc, which indicates a higher copper-soil interaction. The low velocities of the solutions resulted in low dispersion-diffusion coefficient values. Cationic competition decreased the soil retention capacity for the cations.

  14. Archive of information about geosamples curated by NMNH collected during NOAA/NOS and USCGS hydrographic surveys

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Prior to August 2001, physical sediment samples collected by U.S. Coast and Geodetic Survey (USCGS) and NOAA National Ocean Service (NOS) personnel during...

  15. Clinical significance of measurement of serum NO/NOS and TNF-α levels after treatment in patients with schizophrenia

    International Nuclear Information System (INIS)

    Nan Deqi; Du Liang; Yang Sixue; Qin Yong

    2007-01-01

    Objective: To explore the significance of changes of serum NO/NOS and TNF-α levels in patients with schizophrenia. Methods: Serum TNF-α (with R/A) and NO/NOS (with bio-chemistry) levels were determined in 41 patients with schizophrenia both before and after treatment as well as in 35 controls. Results:Before treatment the serum NOS, TNF-α levels in the patients were significantly higher than those in controls (P <0.01 ). After six weeks treatment, the levels in patients, though dropped markedly, remained significantly higher (P<0.05). Conclusion: Serum NO/NOS and TNF-α levels were closely related to the diseases process of schizophrenia and were of prognostic values. (authors)

  16. Disruption of COX-2 and eNOS does not confer protection from cardiovascular failure in lipopolysaccharide-treated conscious mice and isolated vascular rings

    DEFF Research Database (Denmark)

    Stæhr, Mette; Madsen, Kirsten; Vanhoutte, Paul M

    2011-01-01

    (NS 398), disruption of COX-2, endothelium removal, or eNOS deletion (eNOS(-/-)) did not improve vascular reactivity after LPS, while the NO synthase blockers 1400W and N(G)-nitro-l-arginine methyl ester prevented loss of tone. COX-2 and eNOS activities are not necessary for LPS-induced decreases...... in blood pressure, heart rate, and vascular reactivity. Inducible NOS activity appears crucial. COX-2 and eNOS are not obvious therapeutic targets for cardiovascular rescue during gram-negative endotoxemic shock....

  17. Mechanisms of suppression of inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells by andrographolide

    Science.gov (United States)

    Chiou, Wen-Fei; Chen, Chieh-Fu; Lin, Jin-Jung

    2000-01-01

    Andrographolide, an active component found in leaves of Andrographis paniculata, has been reported to exhibit nitric oxide (NO) inhibitory property in endotoxin-stimulated macrophages, however, the detailed mechanisms remain unclear. In the present study we investigated the effect of andrographolide on the expression of inducible NO synthase (iNOS) mRNA, protein, and enzyme activity in RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS) plus interferon-γ (IFN-γ).RAW 264.7 cells stimulated with LPS/IFN-γ activated NO production; in this condition andrographolide (1–100 μM) inhibited NO production in a dose-dependent manner with an IC50 value of 17.4±1.1 μM. Andrographolide also reduces the expression of iNOS protein level but without a significant effect on iNOS mRNA. The reduction of iNOS activity is thought to be caused by decreased expression of iNOS protein.In a protein stability assay, andrographolide moderately but significantly reduced the amount of iNOS protein as suggested by accelerating degradation. Furthermore, andrographolide also inhibited total protein de novo synthesis as demonstrated by [35S]-methionine incorporation.As a whole, these data suggest that andrographolide inhibits NO synthesis in RAW 264.7 cells by reducing the expression of iNOS protein and the reduction could occur through two additional mechanisms: prevention of the de novo protein synthesis and decreasing the protein stability via a post-transcriptional mechanism. It is also possible that inhibition of iNOS protein expression and NO production under immune stimulation and/or bacteria infection may explain, in part, the beneficial effects of andrographolide as an anti-inflammatory agent. PMID:10780958

  18. Educação permanente em saúde: uma estratégia para a formação dos agentes comunitários de saúde Educación continua en materia de salud: una estrategia para la formación de agentes de salud de la comunidad Continuing health educating: a strategy for the training of community health agents

    Directory of Open Access Journals (Sweden)

    Vanessa Baliego de Andrade Barbosa

    2012-03-01

    Full Text Available Este artigo teve por objetivo descrever e analisar o processo de educação dos Agentes Comunitários da Saúde (ACS utilizado pelos enfermeiros na Estratégia Saúde da Família. Trata-se de uma pesquisa qualitativa, e contou com 17 sujeitos. Para a coleta de dados, utilizou-se entrevista semiestruturada, e a análise dos dados foi realizada por meio da técnica de análise de conteúdo. Identificou-se a categoria: organização do processo de educação nas unidades de saúde da família, cujas temáticas elencadas foram: enfermeiros como líderes da equipe de referência, educação permanente, metodologias tradicionais e educação centrada nas necessidades dos ACS. Através deste estudo, pudemos compreender que os enfermeiros têm pouco contato com a ferramenta da Educação Permanente, realizando as atividades de capacitação fundamentadas na metodologia tradicional de ensino, sendo necessário um investimento dos gestores no sentido de capacitá-los, no que se refere à educação permanente, possibilitando-lhes a atuação com os ACS.Este artículo objetivó describir y analizar el proceso de educacional de los Agentes Comunitarios de Salud (ACS, usan todo el enfermeros en la estrategia de la Salud de la Familia. Acerca de una pesquisa cualitativa, contó con 17 sujetos. Para la colección de datos, eligió-se la entrevista semi-estructurada y el análisis través la técnica del análisis del contenido .Fue identificada una categoría: la organización del proceso educacional en las unidades de la Salud de la Familia, cuyas temáticas elegidas fueron: enfermeros como líderes del equipo de referencia, educación permanente, metodologías tradicionales y educación centrada en las necesidades de los ACS. Través de este estudio pudimos comprender que los enfermeros poseen poca aproximación con la herramienta de educación permanente, realizando las actividades de capacitación de los ACS basadas en la metodología tradicional de ense

  19. A gestão urbana e ocupação em áreas de preservação permanente na cidade de Guarapuava (PR: o caso do arroio do Carro Quebrado / Management in urban areas and occupation of permanent preservation areas in the city of Guarapuava (PR: the case of the

    Directory of Open Access Journals (Sweden)

    Nilmar Pussinini

    2011-04-01

    Full Text Available Na cidade, o capitalismo se reproduz de forma muito dinâmica. É nela, que o ambiente, antes natural, torna-se cada vez mais artificial, ou seja, ambiente construído. Com isso, cada vez mais o relevo e os rios são cobertos pelas edificações. Neste contexto, falar de áreas de preservação permanente nas cidades correlacionando-as com as políticas públicas que gerenciam e gestam as cidades, bem como o processo de produção e reprodução do espaço urbano é algo complexo, pois envolve muitos interesses, principalmente dos agentes que o produzem. Neste contexto o trabalho visa discutir as condições socioambientais das áreas de preservação permanente na cidade. As áreas de preservação permanente são preocupações da temática ambiental relacionadas à sociedade e ao ambiente. Preservá-las é uma preocupação social, que envolve a discussão de conceitos como a natureza, preservação, e qualidade de vida no meio ambiente urbano. Através de imagens de satélite, fotografias aéreas e dados coletados, diretamente no campo, buscamos localizar e espacializar as informações, de forma a obter uma visão de conjunto da distribuição do curso hídrico estudado, juntamente com as condições das áreas ao seu em torno que, a priori, deveriam ser destinadas à preservação permanente. Em Guarapuava, há uma importante rede de drenagem, contudo, os rios urbanos estão praticamente todos canalizados, e aqueles que ainda preservam seu curso original, estão degradados pelo lançamento de esgoto e assoreamento. Pensar condições e formas de planejamento e de gestão pública voltados para a conservação dessas áreas que a priori seriam de preservação, é um caminho para a recuperação dos cursos hídricos que ainda resistem à expansão da cidade. AbstractIn the urban area, capitalism increases really dinamically, it is in this place that the natural environment becomes more and more artificial, that is, a built environment. Thus

  20. Conformance to Generic Letter 83-28, Items 3.1.3 and 3.2.3, Beaver Valley, Unit No. 1, North Anna, Unit Nos. 1 and 2, Surry Unit Nos. 1 and 2 (Docket Nos. 50-334, 50-338, 50-339, 50-280, and 50-281)

    International Nuclear Information System (INIS)

    Haroldsen, R.

    1985-09-01

    This report provides a review of the submittals for Beaver Valley, Unit No. 1, North Anna, Unit Nos. 1 and 2, and Surry, Unit Nos. 1 and 2, for conformance to Generic Letter 83-28, Items 3.1.3 and 3.2.3. The specific plants selected were reviewed as a group because of similarity in type and applicability of review items