WorldWideScience

Sample records for normal performance envelope

  1. Benchmarking energy performance of residential buildings using two-stage multifactor data envelopment analysis with degree-day based simple-normalization approach

    International Nuclear Information System (INIS)

    Wang, Endong; Shen, Zhigang; Alp, Neslihan; Barry, Nate

    2015-01-01

    Highlights: • Two-stage DEA model is developed to benchmark building energy efficiency. • Degree-day based simple normalization is used to neutralize the climatic noise. • Results of a real case study validated the benefits of this new model. - Abstract: Being able to identify detailed meta factors of energy performance is essential for creating effective residential energy-retrofitting strategies. Compared to other benchmarking methods, nonparametric multifactor DEA (data envelopment analysis) is capable of discriminating scale factors from management factors to reveal more details to better guide retrofitting practices. A two-stage DEA energy benchmarking method is proposed in this paper. This method includes (1) first-stage meta DEA which integrates the common degree day metrics for neutralizing noise energy effects of exogenous climatic variables; and (2) second-stage Tobit regression for further detailed efficiency analysis. A case study involving 3-year longitudinal panel data of 189 residential buildings indicated the proposed method has advantages over existing methods in terms of its efficiency in data processing and results interpretation. The results of the case study also demonstrated high consistency with existing linear regression based DEA.

  2. MHTGR thermal performance envelopes: Reliability by design

    International Nuclear Information System (INIS)

    Etzel, K.T.; Howard, W.W.; Zgliczynski, J.B.

    1992-05-01

    This document discusses thermal performance envelopes which are used to specify steady-state design requirements for the systems of the Modular High Temperature Gas-Cooled Reactor to maximize plant performance reliability with optimized design. The thermal performance envelopes are constructed around the expected operating point accounting for uncertainties in actual plant as-built parameters and plant operation. The components are then designed to perform successfully at all points within the envelope. As a result, plant reliability is maximized by accounting for component thermal performance variation in the design. The design is optimized by providing a means to determine required margins in a disciplined and visible fashion

  3. Performance measurement with fuzzy data envelopment analysis

    CERN Document Server

    Tavana, Madjid

    2014-01-01

    The intensity of global competition and ever-increasing economic uncertainties has led organizations to search for more efficient and effective ways to manage their business operations.  Data envelopment analysis (DEA) has been widely used as a conceptually simple yet powerful tool for evaluating organizational productivity and performance. Fuzzy DEA (FDEA) is a promising extension of the conventional DEA proposed for dealing with imprecise and ambiguous data in performance measurement problems. This book is the first volume in the literature to present the state-of-the-art developments and applications of FDEA. It is designed for students, educators, researchers, consultants and practicing managers in business, industry, and government with a basic understanding of the DEA and fuzzy logic concepts.

  4. The performance of energy efficient residential building envelope systems

    Energy Technology Data Exchange (ETDEWEB)

    Proskiw, G.

    1996-08-01

    The adequacy and durability of residential building envelope systems under actual field conditions were evaluated. A building envelope offers protection from cold, heat, moisture, wind and noise. However, they are exposed to thermal, structural, and moisture stresses and their performance can degrade over time. Envelope performance was evaluated at 20 energy efficient and four conventional, detached modern homes in Winnipeg, Canada. The three complementary measurement tools were wood moisture content (WMC) of framing members, thermographic examinations, and airtightness tests. As expected, energy efficient building envelope systems performed better than the conventional systems. No evidence of envelope degradation was found in any of the energy efficient houses. The building envelopes using polyethylene air barriers performed slightly better than those which used the airtight drywall approach, although both were considered satisfactory. WMC levels were a bit lower in the polyethylene-clad house. 1 ref., 1 tab.

  5. Preserving Envelope Efficiency in Performance Based Code Compliance

    Energy Technology Data Exchange (ETDEWEB)

    Thornton, Brian A. [Thornton Energy Consulting (United States); Sullivan, Greg P. [Efficiency Solutions (United States); Rosenberg, Michael I. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Baechler, Michael C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-06-20

    The City of Seattle 2012 Energy Code (Seattle 2014), one of the most progressive in the country, is under revision for its 2015 edition. Additionally, city personnel participate in the development of the next generation of the Washington State Energy Code and the International Energy Code. Seattle has pledged carbon neutrality by 2050 including buildings, transportation and other sectors. The United States Department of Energy (DOE), through Pacific Northwest National Laboratory (PNNL) provided technical assistance to Seattle in order to understand the implications of one potential direction for its code development, limiting trade-offs of long-lived building envelope components less stringent than the prescriptive code envelope requirements by using better-than-code but shorter-lived lighting and heating, ventilation, and air-conditioning (HVAC) components through the total building performance modeled energy compliance path. Weaker building envelopes can permanently limit building energy performance even as lighting and HVAC components are upgraded over time, because retrofitting the envelope is less likely and more expensive. Weaker building envelopes may also increase the required size, cost and complexity of HVAC systems and may adversely affect occupant comfort. This report presents the results of this technical assistance. The use of modeled energy code compliance to trade-off envelope components with shorter-lived building components is not unique to Seattle and the lessons and possible solutions described in this report have implications for other jurisdictions and energy codes.

  6. Thermal performance envelopes for MHTGRs - Reliability by design

    International Nuclear Information System (INIS)

    Etzel, K.T.; Howard, W.W.; Zgliczynski, J.

    1992-01-01

    Thermal performance envelopes are used to specify steady-state design requirements for the systems of the modular high-temperature gas-cooled reactor (MHTGR) to maximize plant performance reliability with optimized design. The thermal performance envelopes are constructed around the expected operating point to account for uncertainties in actual plant as-built parameters and plant operation. The components are then designed to perform successfully at all points within the envelope. As a result, plant reliability is maximized by accounting for component thermal performance variation in the design. The design is optimized by providing a means to determine required margins in a disciplined and visible fashion. This is accomplished by coordinating these requirements with the various system and component designers in the early stages of the design, applying the principles of total quality management. The design is challenged by the more complex requirements associated with a range of operating conditions, but in return, high probability of delivering reliable performance throughout the plant life is ensured

  7. Performance Based Envelopes: A Theory of Spatialized Skins and the Emergence of the Integrated Design Professional

    Directory of Open Access Journals (Sweden)

    Franca Trubiano

    2013-10-01

    Full Text Available Realigning the design of building envelopes within the measures of air, light and heat has rendered possible an inventive form of practice whose benefits are far in excess of the metrics of data and analysis. For many of its most advanced practitioners, the contemporary design of facades engages the true potential of “performance” when it deepens, broadens and complicates the theoretical dimension of this most liminal of surfaces. Of particular interest to this paper is a discussion of new theoretical paradigms associated with the design and operation of high performance envelopes of which four characteristics of this emergent sub-discipline are herein examined. To begin with, the way in which building envelopes are no longer separators, dividers and barriers between a building’s interior and exterior conditions, but rather, “spatially” defined environments that fully engage the totality of a building’s engineering systems, is discussed. Cantilevered Louvers, Double Skin Facades and Hybrid Conditioned Atria are representative of this new paradigm as is the use of Responsive Technologies to optimize their behaviors. Lastly, the paper examines the rise of the new integrated design building envelope professional called upon to deliver ever-better performing skins, whether in the guise of energy modeler, climate engineer or façade construction specialist. Hence, this paper develops a theoretical structure within which to describe, analyze and interpret the values made possible by this new and expanding field of performance based envelopes.

  8. Photoperiodic envelope: application of the generative design based on the performance of architectural envelopes, the exploring its shape and performance optimization

    International Nuclear Information System (INIS)

    Viquez Alas, Ernesto Alonso

    2013-01-01

    An alternative method of design is demonstrated to be used in the creation of an architectural envelope, through the application of tools and techniques such as algorithms, optimization, parametrization and simulation. The aesthetic criteria of the form are enriched to achieve the decrease in solar radiation rates. The methods and techniques of optimization, simulation, analysis and synthesis are habituated through the study of the contemporary paradigm of generative design and design by performance. Some of the applying of potential benefits an alternative design method and conditions to be met are designed to facilitate its application in the design of envelopes. A study of application and testing is demonstrated to explore the surround topology. The optimization results in relation to reducing the solar incidence are examined in a simulated environment [es

  9. Performative building envelope design correlated to solar radiation and cooling energy consumption

    Science.gov (United States)

    Jacky, Thiodore; Santoni

    2017-11-01

    Climate change as an ongoing anthropogenic environmental challenge is predominantly caused by an amplification in the amount of greenhouse gases (GHGs), notably carbon dioxide (CO2) in building sector. Global CO2 emissions are emitted from HVAC (Heating, Ventilation, and Air Conditioning) occupation to provide thermal comfort in building. In fact, the amount of energy used for cooling or heating building is implication of building envelope design. Building envelope acts as interface layer of heat transfer between outdoor environment and the interior of a building. It appears as wall, window, roof and external shading device. This paper examines performance of various design strategy on building envelope to limit solar radiation and reduce cooling loads in tropical climate. The design strategies are considering orientation, window to wall ratio, material properties, and external shading device. This research applied simulation method using Autodesk Ecotect to investigate simultaneously between variations of wall and window ratio, shading device composition and the implication to the amount of solar radiation, cooling energy consumption. Comparative analysis on the data will determine logical variation between opening and shading device composition and cooling energy consumption. Optimizing the building envelope design is crucial strategy for reducing CO2 emissions and long-term energy reduction in building sector. Simulation technology as feedback loop will lead to better performative building envelope.

  10. Environmental performance evaluation of large-scale municipal solid waste incinerators using data envelopment analysis

    International Nuclear Information System (INIS)

    Chen, H.-W.; Chang, N.-B.; Chen, J.-C.; Tsai, S.-J.

    2010-01-01

    Limited to insufficient land resources, incinerators are considered in many countries such as Japan and Germany as the major technology for a waste management scheme capable of dealing with the increasing demand for municipal and industrial solid waste treatment in urban regions. The evaluation of these municipal incinerators in terms of secondary pollution potential, cost-effectiveness, and operational efficiency has become a new focus in the highly interdisciplinary area of production economics, systems analysis, and waste management. This paper aims to demonstrate the application of data envelopment analysis (DEA) - a production economics tool - to evaluate performance-based efficiencies of 19 large-scale municipal incinerators in Taiwan with different operational conditions. A 4-year operational data set from 2002 to 2005 was collected in support of DEA modeling using Monte Carlo simulation to outline the possibility distributions of operational efficiency of these incinerators. Uncertainty analysis using the Monte Carlo simulation provides a balance between simplifications of our analysis and the soundness of capturing the essential random features that complicate solid waste management systems. To cope with future challenges, efforts in the DEA modeling, systems analysis, and prediction of the performance of large-scale municipal solid waste incinerators under normal operation and special conditions were directed toward generating a compromised assessment procedure. Our research findings will eventually lead to the identification of the optimal management strategies for promoting the quality of solid waste incineration, not only in Taiwan, but also elsewhere in the world.

  11. Environmental performance evaluation of large-scale municipal solid waste incinerators using data envelopment analysis.

    Science.gov (United States)

    Chen, Ho-Wen; Chang, Ni-Bin; Chen, Jeng-Chung; Tsai, Shu-Ju

    2010-07-01

    Limited to insufficient land resources, incinerators are considered in many countries such as Japan and Germany as the major technology for a waste management scheme capable of dealing with the increasing demand for municipal and industrial solid waste treatment in urban regions. The evaluation of these municipal incinerators in terms of secondary pollution potential, cost-effectiveness, and operational efficiency has become a new focus in the highly interdisciplinary area of production economics, systems analysis, and waste management. This paper aims to demonstrate the application of data envelopment analysis (DEA)--a production economics tool--to evaluate performance-based efficiencies of 19 large-scale municipal incinerators in Taiwan with different operational conditions. A 4-year operational data set from 2002 to 2005 was collected in support of DEA modeling using Monte Carlo simulation to outline the possibility distributions of operational efficiency of these incinerators. Uncertainty analysis using the Monte Carlo simulation provides a balance between simplifications of our analysis and the soundness of capturing the essential random features that complicate solid waste management systems. To cope with future challenges, efforts in the DEA modeling, systems analysis, and prediction of the performance of large-scale municipal solid waste incinerators under normal operation and special conditions were directed toward generating a compromised assessment procedure. Our research findings will eventually lead to the identification of the optimal management strategies for promoting the quality of solid waste incineration, not only in Taiwan, but also elsewhere in the world. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

  12. Fast digital envelope detector based on generalized harmonic wavelet transform for BOTDR performance improvement

    International Nuclear Information System (INIS)

    Yang, Wei; Yang, Yuanhong; Yang, Mingwei

    2014-01-01

    We propose a fast digital envelope detector (DED) based on the generalized harmonic wavelet transform to improve the performance of coherent heterodyne Brillouin optical time domain reflectometry. The proposed DED can obtain undistorted envelopes due to the zero phase-shift ideal bandpass filter (BPF) characteristics of the generalized harmonic wavelet (GHW). Its envelope average ability benefits from the passband designing flexibility of the GHW, and its demodulation speed can be accelerated by using a fast algorithm that only analyses signals of interest within the passband of the GHW with reduced computational complexity. The feasibility and advantage of the proposed DED are verified by simulations and experiments. With an optimized bandwidth, Brillouin frequency shift accuracy improvements of 19.4% and 11.14%, as well as envelope demodulation speed increases of 39.1% and 24.9%, are experimentally attained by the proposed DED over Hilbert transform (HT) and Morlet wavelet transform (MWT) based DEDs, respectively. Spatial resolution by the proposed DED is undegraded, which is identical to the undegraded value by HT-DED with an allpass filter characteristic and better than the degraded value by MWT-DED with a Gaussian BPF characteristic. (paper)

  13. 14 CFR 27.87 - Height-speed envelope.

    Science.gov (United States)

    2010-01-01

    ... applicable power failure condition in paragraph (b) of this section, a limiting height-speed envelope must be... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Height-speed envelope. 27.87 Section 27.87... STANDARDS: NORMAL CATEGORY ROTORCRAFT Flight Performance § 27.87 Height-speed envelope. (a) If there is any...

  14. Biomimetic Envelopes

    OpenAIRE

    Ilaria Mazzoleni

    2010-01-01

    How to translate the lessons learned from the analysis and observation of the animal world is the design learning experience presented in this article. Skin is a complex and incredibly sophisticated organ that performs various functions, including protection, sensation and heat and water regulation. In a similar way building envelopes serve multiple roles, as they are the interface between the building inhabitants and environmental elements. The resulting architectural building envelopes prot...

  15. Using data envelopment analysis to evaluate the performance of post-hurricane electric power restoration activities

    International Nuclear Information System (INIS)

    Reilly, Allison C.; Davidson, Rachel A.; Nozick, Linda K.; Chen, Thomas; Guikema, Seth D.

    2016-01-01

    Post-hurricane restoration of electric power is attracting increasing scrutiny as customers’ tolerance for even short power interruptions decreases. At the peak, 8.5 million customers were without power after Hurricane Sandy and over 1 million customers were without power more than a week after the storm made landfall. Currently, restoration processes are typically evaluated on a case-by-case basis by a regional public service commission or similar body and lack systematic comparisons to other restoration experiences. This paper introduces a framework using data envelopment analysis to help evaluate post-hurricane restorations through comparison with the experiences of other companies in similar storms. The method accounts for the variable severity of the hurricanes themselves, so that companies are not penalized for outages that are long only because the hurricane that caused them was particularly severe. The analysis is illustrated through an application comparing 27 recent post-hurricane restoration experiences across 13 different electric power companies in the United States. The results of the study show some consistency in performance among individual utilities after the hurricanes they experience. The method could be applied to other types of infrastructure systems and other extreme events as well. - Highlights: • A Data Envelopment Analysis (DEA) framework is developed to compare post- hurricane power-outage restoration performance. • Hurricane severity is considered, so that utilities are not penalized for long outages caused by severe storms. • A case study using real data compares 27 recent post-hurricane restoration experiences. • The results of the study show utilities tend to perform consistently after the hurricanes they experience.

  16. Building envelope influence on the annual energy performance in office buildings

    Directory of Open Access Journals (Sweden)

    Harmati Norbert L.

    2016-01-01

    Full Text Available The objective of the research is to determine the quantitative influence of building envelope on the annual heating and cooling energy demand in office buildings demonstrated on a reference office-tower building located in Novi Sad, Serbia. The investigation intended to find preferable and applicable solutions for energy performance improvement in currently inefficient office buildings. A comparative and evaluative analysis was performed among the heating energy expenses and simulated values from the multi-zone model designed in EnergyPlus engine. The research determines an improved window to wall ratio using dynamic daylight simulation and presents the influence of glazing parameters (U-value, Solar heat gain coefficient - SHGC on the annual energy performance. Findings presented window to wall ratio reduction down to 30% and point out the significance of the SHGC parameter on the overall energy performance of buildings with high internal loads. The calculation of the air-ventilation energy demand according to EN 15251 is included respectively. Results offer effective methods for energy performance improvement in temperate climate conditions.

  17. Data Envelopment Analysis as a Tool for Evaluation of Employees Performance

    Directory of Open Access Journals (Sweden)

    ZBRANEK

    2013-02-01

    Full Text Available Employee performance evaluation systems, which are well designed and properly used, are essential for the effective functioning of the organization. Due to some disadvantages of traditional methods, there is a need to develop new evaluation procedures. The main contribution of this paper is to apply a multidimensional approach, represented by the method of Data Envelopment Analysis (DEA to measure the performance and efficiency of employees. This approach overcomes several weaknesses of traditional systems of the employees’ performance evaluation and provides a comprehensive indicator of the performance of individual employees, their technical efficiency score. The input variables of the used model were the motivational factors (salary, working conditions and benefits; the output was the indirectly assessed performance through work motivation, job satisfaction and organizational commitment. Furthermore, we applied the nonparametric methods for compliance testing of mean values to validate the stated hypotheses. In a baking company using the DEA method, we identified 12 efficient employees and 48 employees who need to improve their outputs to achieve their maximum efficiency.

  18. Benchmarking the energy performance of office buildings: A data envelopment analysis approach

    Directory of Open Access Journals (Sweden)

    Molinos-Senante, María

    2016-12-01

    Full Text Available The achievement of energy efficiency in buildings is an important challenge facing both developed and developing countries. Very few papers have assessed the energy efficiency of office buildings using real data. To overcome this limitation, this paper proposes an energy efficiency index for buildings having a large window-to-wall ratio, and uses this index to identify the main architectural factors affecting energy performance. This paper assesses, for the first time, the energy performances of 34 office buildings in Santiago, Chile, by using data envelopment analysis. Overall energy efficiency is decomposed into two indices: the architectural energy efficiency index, and the management energy efficiency index. This decomposition is an essential step in identifying the main drivers of energy inefficiency and designing measures for improvement. Office buildings examined here have significant room for improving their energy efficiencies, saving operational costs and reducing greenhouse gas emissions. The methodology and results of this study will be of great interest to building managers and policymakers seeking to increase the sustainability of cities.

  19. High-tech industries' overseas investment performance evaluation - Application of data envelopment analysis

    Directory of Open Access Journals (Sweden)

    Ridong Hu

    2013-12-01

    Full Text Available With the rapid change of the social environment, Mainland China has become a new economic market due to the great domestic demand caused by its enormous population and the increasing economic growth rate. Taiwanese businesses have gradually turned to develop in China under the pressure of increasing domestic wages and land costs for expanding factories as well as the enhancement of environmental protection. Mainland China presents the advantages of ample land, low labor costs, monoethnicity, and easy language communication making it an attractive major investment location for Taiwanese high-tech industries. Data Envelopment Analysis (DEA is applied to measure overseas investment efficiency evaluation of Taiwanese high-tech businesses in China, where the Delphi Method is used for selecting the inputs of the number of employees, R&D expenses, and gross sales in total assets. Sensitivity Analysis is further utilized for acquiring the most efficient unit and individual units with operating efficiency. The research results show that 1.Three high-tech businesses that present constant returns to scale perform optimally with overseas investment efficiency 2.Two high-tech companies with decreasing returns to scale appear that they could improve the overseas investment efficiency by decreasing the scale to enhancing the marginal returns, and 3.Sixteen high-tech enterprises reveal increasing returns to scale, showing that they could expand the scale to enhance the marginal returns and further promote efficiency.

  20. 78 FR 63902 - Special Conditions: Embraer S.A., Model EMB-550 Airplanes; Flight Envelope Protection: Normal...

    Science.gov (United States)

    2013-10-25

    ...): (a) The positive limiting load factor must not be less than: (1) 2.5g for the normal state of the... is readily achievable at operational speeds. For the FAA to consider a trajectory change as...

  1. Performance analysis: a study using data envelopment analysis in 26 Brazilian hospitals.

    Science.gov (United States)

    Guerra, Mariana; de Souza, Antônio Artur; Moreira, Douglas Rafael

    2012-01-01

    This article describes a proposal for analyzing the performance of public Brazilian hospitals using financial and non-financial rates (i.e., operational rates), and thereby highlights the effectiveness (or otherwise) of the financial management of organizations in this study. A total of 72 hospitals in the Brazilian Unified Health Care System (in Portuguese, Sistema Unico de Saúde-SUS), were selected for accessibility and completeness of their data. Twenty-six organizations were used for the study sample, consisting of entities that had publicly disclosed financial statements for the period from 2008 (in particular, via the Internet) and whose operational data could be found in the SUS database. Our proposal, based on models using the method of Data Envelopment Analysis (DEA), was the construction of six initial models that were later compiled into a standard model. The relations between the rates that comprised the models were based on the variables and the notes of: Schuhmann, McCue and Nayar, Barnum and Kutzin, Younis, Younies, and Okojie, Marinho, Moreno, and Cavalini, and Ersoy, Kavuncubasi, Ozcan, and Harris II. We put forward an enhanced grant proposal applicable to Brazil aiming to (i) confirm or refute the rates that show the effectiveness or ineffectiveness of financial management of national hospitals; and (ii) determine the best performances, which could be used as a reference for future studies. Obtained results: (i) for all financial indicators considered, only one showed no significance in all models; and (ii) for operational indicators, the results were not relevant when the number of occupied beds was considered. Though the analysis was related to only services provided by SUS, we conclude that our study has great potential for analyzing the financial management performance of Brazilian hospitals in general, for the following reasons: (i) it shows the relationship of financial and operational rates that can be used to analyze the performance of

  2. 78 FR 76249 - Special Conditions: Airbus, Model A350-900 Series Airplane; Flight Envelope Protection: Normal...

    Science.gov (United States)

    2013-12-17

    ..., and accommodates side-by-side placement of LD-3 containers in the cargo compartment. The basic Airbus... availability of this excess maneuver capacity in case of extreme emergency such as upset recoveries or... factor must not be less than: (a) 2.5g for the EFCS normal state with the high lift devices retracted up...

  3. Design of the Building Envelope: A Novel Multi-Objective Approach for the Optimization of Energy Performance and Thermal Comfort

    Directory of Open Access Journals (Sweden)

    Fabrizio Ascione

    2015-08-01

    Full Text Available According to the increasing worldwide attention to energy and the environmental performance of the building sector, building energy demand should be minimized by considering all energy uses. In this regard, the development of building components characterized by proper values of thermal transmittance, thermal capacity, and radiative properties is a key strategy to reduce the annual energy need for the microclimatic control. However, the design of the thermal characteristics of the building envelope is an arduous task, especially in temperate climates where the energy demands for space heating and cooling are balanced. This study presents a novel methodology for optimizing the thermo-physical properties of the building envelope and its coatings, in terms of thermal resistance, capacity, and radiative characteristics of exposed surfaces. A multi-objective approach is adopted in order to optimize energy performance and thermal comfort. The optimization problem is solved by means of a Genetic Algorithm implemented in MATLAB®, which is coupled with EnergyPlus for performing dynamic energy simulations. For demonstration, the methodology is applied to a residential building for two different Mediterranean climates: Naples and Istanbul. The results show that for Naples, because of the higher incidence of cooling demand, cool external coatings imply significant energy savings, whereas the insulation of walls should be high but not excessive (no more than 13–14 cm. The importance of high-reflective coating is clear also in colder Mediterranean climates, like Istanbul, although the optimal thicknesses of thermal insulation are higher (around 16–18 cm. In both climates, the thermal envelope should have a significant mass, obtainable by adopting dense and/or thick masonry layers. Globally, a careful design of the thermal envelope is always necessary in order to achieve high-efficiency buildings.

  4. Thermal performance analysis of PCM in refrigerated container envelopes in the Italian context – Numerical modeling and validation

    International Nuclear Information System (INIS)

    Copertaro, Benedetta; Principi, Paolo; Fioretti, Roberto

    2016-01-01

    Highlights: • A refrigerated container with PCMs was evaluated in the Italian climatic context. • The numerical results were validated by an experimental campaign. • A 4.23% of mean bias was achieved comparing the numerical and experimental results. • PCMs application leads to a reduction in peak heat load of 20%. • An energy rate reduction of 4.65% was obtained in the PCMs added container. - Abstract: Due to external climatic conditions, radiation and temperature, refrigerated containers are subjected to high thermal stresses during storage in yards, warehouses, ships or during transport by rail or road. Moreover the consequent high thermal load has a great influence on both the electric and fuel energy consumption and on combined greenhouse gas emissions into the atmosphere. The aim of this research is the theoretical evaluation, using a previously validated Finite Element Method (FEM), of the related energy benefits deriving from the application of PCMs (Phase Change Materials) to a traditional refrigerated container envelope. Specifically the numerical analysis was performed for several kinds of PCMs, climatic conditions and exposures. The study also provides a numerical tool to be used in the prediction of the thermal performance of refrigerated container envelopes with PCM in the Italian context. An experimental analysis was carried out in order to test the accuracy of the numerical model and to validate it. Results show that PCM application to a 20’ ISO container envelope can reduce and shift the daily heat load phases with respect to a traditional envelope fitted only with insulating materials.

  5. Prospective national and regional environmental performance: Boundary estimations using a combined data envelopment - stochastic frontier analysis approach

    International Nuclear Information System (INIS)

    Vaninsky, Alexander

    2010-01-01

    The environmental performance of regions and largest economies of the world - actually, the efficiency of their energy sectors - is estimated for the period 2010-2030 by using forecasted values of main economic indicators. Two essentially different methodologies, data envelopment analysis and stochastic frontier analysis, are used to obtain upper and lower boundaries of the environmental efficiency index. Greenhouse gas emission per unit of area is used as a resulting indicator, with GDP, energy consumption, and population forming a background of comparable estimations. The dynamics of the upper and lower boundaries and their average is analyzed. Regions and national economies having low level or negative dynamics of environmental efficiency are determined.

  6. Evaluation of thermal power plant operational performance in Taiwan by data envelopment analysis

    International Nuclear Information System (INIS)

    Liu, C.H.; Lin, Sue J.; Lewis, Charles

    2010-01-01

    Electricity is essential in the economic development of a nation. Due to the rapid growth of economy and industrial development in Taiwan, the demand for use of electricity has increased rapidly. This study evaluates the power-generation efficiency of major thermal power plants in Taiwan during 2004-2006 using the data envelopment analysis (DEA) approach. A stability test was conducted to verify the stability of the DEA model. According to the results, all power plants studied achieved acceptable overall operational efficiencies during 2004-2006, and the combined cycle power plants were the most efficient among all plants. The most important variable in this DEA model is the 'heating value of total fuels'. Findings from this study can be beneficial in improving some of the existing power plants and for more efficient operational strategies and related policy-making for future power plants in Taiwan.

  7. H2-O2 fuel cell and advanced battery power systems for autonomous underwater vehicles: performance envelope comparisons

    International Nuclear Information System (INIS)

    Schubak, G.E.; Scott, D.S.

    1993-01-01

    Autonomous underwater vehicles have traditionally been powered by low energy density lead-acid batteries. Recently, advanced battery technologies and H 2 -O 2 fuel cells have become available, offering significant improvements in performance. This paper compares the solid polymer fuel cell to the lithium-thionyl chloride primary battery, sodium-sulfur battery, and lead acid battery for a variety of missions. The power system performance is simulated using computer modelling techniques. Performance envelopes are constructed, indicating domains of preference for competing power system technologies. For most mission scenarios, the solid polymer fuel cell using liquid reactant storage is the preferred system. Nevertheless, the advanced battery systems are competitive with the fuel cell systems using gaseous hydrogen storage, and they illustrate preferred performance for missions requiring high power density. 11 figs., 4 tabs., 15 refs

  8. Building envelope

    CSIR Research Space (South Africa)

    Gibberd, Jeremy T

    2009-01-01

    Full Text Available for use in the building. This is done through photovoltaic and solar water heating panels and wind turbines. Ideally these are integrated in the design of the building envelope to improve the aesthetic quality of the building and minimise material... are naturally ventilated. Renewable energy The building envelope includes renewable energy generation such as photovoltaics, wind turbines and solar water heaters and 10% of the building’s energy requirements are generated from these sources. Views All...

  9. PV System Performance Evaluation by Clustering Production Data to Normal and Non-Normal Operation

    NARCIS (Netherlands)

    Tsafarakis, O.; Sinapis, K.; van Sark, W.G.J.H.M.

    2018-01-01

    The most common method for assessment of a photovoltaic (PV) system performance is by comparing its energy production to reference data (irradiance or neighboring PV system). Ideally, at normal operation, the compared sets of data tend to show a linear relationship. Deviations from this linearity

  10. Designing Performance Measurement For Supply Chain's Actors And Regulator Using Scale Balanced Scorecard And Data Envelopment Analysis

    Science.gov (United States)

    Kusrini, Elisa; Subagyo; Aini Masruroh, Nur

    2016-01-01

    This research is a sequel of the author's earlier conducted researches in the fields of designing of integrated performance measurement between supply chain's actors and regulator. In the previous paper, the design of performance measurement is done by combining Balanced Scorecard - Supply Chain Operation Reference - Regulator Contribution model and Data Envelopment Analysis. This model referred as B-S-Rc-DEA model. The combination has the disadvantage that all the performance variables have the same weight. This paper investigates whether by giving weight to performance variables will produce more sensitive performance measurement in detecting performance improvement. Therefore, this paper discusses the development of the model B-S-Rc-DEA by giving weight to its performance'variables. This model referred as Scale B-S-Rc-DEA model. To illustrate the model of development, some samples from small medium enterprises of leather craft industry supply chain in province of Yogyakarta, Indonesia are used in this research. It is found that Scale B-S-Rc-DEA model is more sensitive to detecting performance improvement than B-S- Rc-DEA model.

  11. Balancing energy and daylighting performances for envelope design: A new index and proposition of a case study in Hong Kong

    International Nuclear Information System (INIS)

    Xie, Jing Chao; Xue, Peng; Mak, Cheuk Ming; Liu, Jia Ping

    2017-01-01

    Highlights: •Daylighting and energy performances were studied simultaneously. •Energy demands of lighting and air-conditioning systems were both included. •Luminous comfort was quantified by Ave. DA 300 with the range from 29.6% to 57.8%. •Energy Daylight Rate was proposed as a simple multi-objective optimization approach. •Optimal scenarios for all directions were tested and chosen by EDR method. -- Abstract: Being healthy and energy saving have become two important principles of building development. Daylight is an influential factor with the characteristics of both photometry and radiometry. Irradiance brings solar heat gains that transfer to building cooling load, while illuminance provides a luminous environment and affects artificial lighting system at the same time. To balance the energy and daylighting performances, it is reasonable to minimize the environmental load under moderate comfort conditions. This study first quantified luminous comfort with a dynamic daylighting metric, average daylight autonomy (Ave. DA 300 ), from a questionnaire survey and simulation work. The benchmark of this metric should range from 29.6% to 57.8% for high-rise residential buildings. With this guideline, the Hong Kong public housing units is found that part of units lack of daylight due to the high building floor and density, while some units have potential to save energy by compromising daylighting performance. Therefore, a new index, energy daylight rate (EDR), is proposed to help decide the best scenario of envelope design for both daylighting and shading purposes. The results show that opening a secondary window is an efficient way to bring more light in and lengthening overhang is an efficient way to block excessive sunlight. This method and the new index are proved to have the ability to help defining proper building envelope design at the early stage.

  12. Airports’ Operational Performance and Efficiency Evaluation Based on Multicriteria Decision Analysis (MCDA and Data Envelopment Analysis (DEA Tools

    Directory of Open Access Journals (Sweden)

    João Jardim

    2015-12-01

    Full Text Available Airport benchmarking depends on airports’ operational performance and efficiency indicators, which are important for business agents, operational managers, regulatory agencies, airlines and passengers. There are several sets of single and complex indicators to evaluate airports’ performance and efficiency as well as several techniques to benchmark such infrastructures. The general aim of this work is twofold: to balance the data envelopment analysis (DEA and multicriteria decision analysis (MCDA tools and to show that airport benchmarking is also possible using a multicriteria decision analysis tool called Measuring Attractiveness by a Categorical Based Evaluation Technique (MACBETH. Whilst DEA measures the relative performance in the presence of multiple inputs and outputs, MCDA/ MACBETH uses performance and efficiency indicators to support benchmark results, being useful for evaluating the real importance and weight of the selected indicators. The work is structured as follows: first, a state-of-the-art review concerning either airport benchmarking and performance indicators or DEA and MCDA tool techniques; second, an overview of the impacts on airports’ operational performance and efficiency of emergent operational factors (sudden meteorological/natural phenomena; third, two case studies on a set of worldwide airports and Madeira (FNC Airport; and fourth, some insights into and challenges for future research that are still under development.

  13. Evaluating knowledge outsourcing performance Of public sectors with data envelopment Analysis

    Directory of Open Access Journals (Sweden)

    Liu, Hong-Cheng

    2014-11-01

    Full Text Available With the governmental sectors imitating the reformation of enterprises stressing on Knowledge, Contracting Out and Deregulation have become the core policies. Contracting Out is not based on the arbitrariness of an administrator, but the selective efficiency and competition. Connecting the resources between Public and Private Sectors is a concern of Contracting Out, while Knowledge Outsourcing is an innovation to enhance organizational knowledge and the reduction of organizational ignorance. Based on a Knowledge Outsourcing Investigation by the Kaohsiung City Government (Taiwan in the past few years, Data Envelopment Analysis (DEA and Sensitivity Analysis are integrated for measuring the total efficiency (TE, pure technical efficiency (PTE, and scale efficiency (SE of Knowledge Outsourcing of the sectors in the Kaohsiung City Government for the improvement reference of other counties and cities. From the message acquired from the efficiency and variables with the DEA, one DMU (Data Management Unit, or about 5% of all DMUs, appears to have strong Knowledge Outsourcing efficiency 1, showing favorable Knowledge Outsourcing efficiency. Two DMUs, comprising about 10% of all DMUs, reveal the marginal Knowledge Outsourcing inefficiency between 0.9 and 1. This implies that such sectors could better enhance the Knowledge Outsourcing efficiency. 17 DMUs, representing about 85% of all DMUs, exhibit an obvious Knowledge Outsourcing inefficiency of less than 0.9, so that the Finance and Transportation Bureaus present the lowest Knowledge Outsourcing efficiency.En la medida en que el sector público imita la reforma de aquellas empresas que ponen el acento en el conocimiento, la subcontratación y la desregulación se han convertido en las principales políticas. La subcontratación no se basa en la arbitrariedad de un gestor público, sino en la eficacia selectiva y la competencia. El interés de la subcontratación consiste en poner en contacto los recursos

  14. Energy performance and optimal control of air-conditioned buildings with envelopes enhanced by phase change materials

    International Nuclear Information System (INIS)

    Zhu Na; Wang Shengwei; Ma Zhenjun; Sun Yongjun

    2011-01-01

    Highlights: → Impact of PCM on the energy consumption and peak load demand as well as electricity cost of air-conditioned buildings. → Impact of load shifting control on energy consumption, peak load and electricity cost of air-conditioned PCM buildings. → Impact of demand limiting control on energy consumption, peak load and electricity cost of air-conditioned PCM buildings. → Energy/cost effects of different control strategies and use of PCM in energy-plus-demand-based pricing policy. → Energy/cost effects of different control strategies and use of PCM in time-based pricing policy. - Abstract: Studies are conducted to investigate the impacts of shape-stabilized phase change material (SSPCM) and different control strategies on the energy consumption and peak load demand as well as electricity cost of building air-conditioning systems at typical summer conditions in two climates (subtropical and dry continental climates). An office building using a typical variable air volume (VAV) air-conditioning system was selected and simulated as the reference building in this study. Its envelopes were enhanced by integrating the SSPCM layers into its walls while the air-conditioning system and other configurations of the building remained unchanged. The building system was tested under two typical weather conditions and two typical electricity pricing policies (i.e. time-based pricing and energy-plus-demand-based pricing). Test results show that the use of SSPCM in the building could reduce the building electricity cost significantly (over 11% in electricity cost reduction and over 20% in peak load reduction), under two pricing policies by using load shifting control and demand limiting control respectively. This paper presents the test results and the evaluation on the energy performance and the optimal control strategies of air-conditioned commercial buildings with envelopes enhanced by SSPCM.

  15. Development of Data Envelopment Analysis for the Performance Evaluation of Green Supply Chain with Undesirable Outputs

    Directory of Open Access Journals (Sweden)

    Alireza Alinezhad

    2016-08-01

    Full Text Available A fundamental problem is the use of DEA in multistep or multilevel processes such as supply chain, lack of attention to processes’ internal communications in a way that the recent studies on DEA in the context of serial processes have focused on closed systems that the outputs of one level become the inputs of the next level and none of the inputs enter the mediator process. The present study aimed to examine the general dimensions of an open multilevel process. Here, some of the data such as inputs and outputs are supposed to leave the system while other outputs turn into the inputs of the next level. The new inputs can enter the next level as well. We expand this mode for network structures. The overall performance of such a structure is considered as a weighted average of sectors’ performance or distinct steps. Therefore, this suggested model in this study, not only provides the possibility to evaluate the performance of the entire network, but creates the performance analysis for each of the sub-processes. On the other hand, considering the data with undesirable structure leads to more correct performance estimation. In the real world, all productive processes do not comprise desirable factors. Therefore, presenting a structure that is capable of taking into account the undesirable structure is of crucial importance. In this study, a new model in the DEA by network structure is offered that can analyze the performance considering undesirable factors.

  16. Performance Evaluation of Modern Building Thermal Envelope Designs in the Semi-Arid Continental Climate of Tehran

    Directory of Open Access Journals (Sweden)

    Shaghayegh Mohammad

    2013-10-01

    Full Text Available In this paper we evaluate the thermal performance of a range of modern wall constructions used in the residential buildings of Tehran in order to find the most appropriate alternative to the traditional un-fired clay and brick materials, which are increasingly being replaced in favor of more slender wall constructions employing hollow clay, autoclaved aerated concrete or light expanded clay aggregate blocks. The importance of improving the building envelope through estimating the potential for energy saving due to the application of the most energy-efficient wall type is presented and the wall constructions currently erected in Tehran are introduced along with their dynamic and steady-state thermal properties. The application of a dynamic simulation tool is explained and the output of the thermal simulation model is compared with the dynamic thermal properties of the wall constructions to assess their performance in summer and in winter. Finally, the best and worst wall type in terms of their cyclic thermal performance and their ability to moderate outdoor conditions is identified through comparison of the predicted indoor temperature and a target comfort temperature.

  17. Evaluation of Teaching Performance of English Courses by Applying Data Envelopment Analysis and Two-phase Segmentation

    Directory of Open Access Journals (Sweden)

    Bernard Montoneri

    2013-05-01

    Full Text Available Effective teaching performance is a crucial factor contributing to students’ learning improvement. Students’ ratings of teachers at the end of each semester can indirectly provide valuable information about teachers’ performance. This paper selects classes of freshmen students taking a course of English in a university of Taiwan from the academic year 2004 to 2006 as the research object. We adopt the data envelopment analysis, a reliable and robust evaluation method, to identify the relative efficiencies of each class. The calculation is performed in two phases. In phase 1, all the classes are in the same pool. The results of numerical analysis in phase 1 are used to clarify whether the existing teaching methods can achieve the desired results and what are the improved methods. Based on the calculation of phase 1, we segment all the classes into 2 groups according to their contribution of output indicators in calculating efficiency values. The empirical results are expected to identify more objective classes and to reveal that the evaluated classes refer to different efficient classes in different phases and their ranking order changes accordingly. This method can help to provide some concrete and practical teaching strategies for the inefficient classes.

  18. A framework for performance measurement in university using extended network data envelopment analysis (DEA) structures

    Science.gov (United States)

    Kashim, Rosmaini; Kasim, Maznah Mat; Rahman, Rosshairy Abd

    2015-12-01

    Measuring university performance is essential for efficient allocation and utilization of educational resources. In most of the previous studies, performance measurement in universities emphasized the operational efficiency and resource utilization without investigating the university's ability to fulfill the needs of its stakeholders and society. Therefore, assessment of the performance of university should be separated into two stages namely efficiency and effectiveness. In conventional DEA analysis, a decision making unit (DMU) or in this context, a university is generally treated as a black-box which ignores the operation and interdependence of the internal processes. When this happens, the results obtained would be misleading. Thus, this paper suggest an alternative framework for measuring the overall performance of a university by incorporating both efficiency and effectiveness and applies network DEA model. The network DEA models are recommended because this approach takes into account the interrelationship between the processes of efficiency and effectiveness in the system. This framework also focuses on the university structure which is expanded from the hierarchical to form a series of horizontal relationship between subordinate units by assuming both intermediate unit and its subordinate units can generate output(s). Three conceptual models are proposed to evaluate the performance of a university. An efficiency model is developed at the first stage by using hierarchical network model. It is followed by an effectiveness model which take output(s) from the hierarchical structure at the first stage as a input(s) at the second stage. As a result, a new overall performance model is proposed by combining both efficiency and effectiveness models. Thus, once this overall model is realized and utilized, the university's top management can determine the overall performance of each unit more accurately and systematically. Besides that, the result from the network

  19. Financial performance monitoring of the technical efficiency of critical access hospitals: a data envelopment analysis and logistic regression modeling approach.

    Science.gov (United States)

    Wilson, Asa B; Kerr, Bernard J; Bastian, Nathaniel D; Fulton, Lawrence V

    2012-01-01

    From 1980 to 1999, rural designated hospitals closed at a disproportionally high rate. In response to this emergent threat to healthcare access in rural settings, the Balanced Budget Act of 1997 made provisions for the creation of a new rural hospital--the critical access hospital (CAH). The conversion to CAH and the associated cost-based reimbursement scheme significantly slowed the closure rate of rural hospitals. This work investigates which methods can ensure the long-term viability of small hospitals. This article uses a two-step design to focus on a hypothesized relationship between technical efficiency of CAHs and a recently developed set of financial monitors for these entities. The goal is to identify the financial performance measures associated with efficiency. The first step uses data envelopment analysis (DEA) to differentiate efficient from inefficient facilities within a data set of 183 CAHs. Determining DEA efficiency is an a priori categorization of hospitals in the data set as efficient or inefficient. In the second step, DEA efficiency is the categorical dependent variable (efficient = 0, inefficient = 1) in the subsequent binary logistic regression (LR) model. A set of six financial monitors selected from the array of 20 measures were the LR independent variables. We use a binary LR to test the null hypothesis that recently developed CAH financial indicators had no predictive value for categorizing a CAH as efficient or inefficient, (i.e., there is no relationship between DEA efficiency and fiscal performance).

  20. [Performance of normal young adults in two temporal resolution tests].

    Science.gov (United States)

    Zaidan, Elena; Garcia, Adriana Pontin; Tedesco, Maria Lucy Fraga; Baran, Jane A

    2008-01-01

    temporal auditory processing is defined as the perception of sound or of sound alteration within a restricted time interval and is considered a fundamental ability for the auditory perception of verbal and non verbal sounds, for the perception of music, rhythm, periodicity and in the discrimination of pitch, duration and of phonemes. to compare the performance of normal Brazilian adults in two temporal resolution tests: the Gaps-in-Noise Test (GIN) and the Random Gap Detection Test (RGDT), and to analyze potential differences of performance in these two tests. twenty-five college students with normal hearing (11 males and 14 females) and no history of educational, neurological and/or language problems, underwent the GIN and RGDT at 40dB SL. statistically significant gender effects for both tests were found, with female participants showing poorer performance on both temporal processing tests. In addition, a comparative analysis of the results obtained in the GIN and RGDT revealed significant differences in the threshold measures derived for these two tests. In general, significantly better gap detection thresholds were observed for both male and female participants on the GIN test when compared to the results obtained for the RGDT. male participants presented better performances on both RGDT and GIN, when compared to the females. There were no differences in performance between right and left ears on the GIN test. Participants of the present investigation, males and females, performed better on the GIN when compared to the RGDT. The GIN presented advantages over the RGDT, not only in terms of clinical validity and sensibility, but also in terms of application and scoring.

  1. Optimum Application of Thermal Factors to Artificial Neural Network Models for Improvement of Control Performance in Double Skin-Enveloped Buildings

    Directory of Open Access Journals (Sweden)

    Kyung-Il Chin

    2013-08-01

    Full Text Available This study proposes an artificial neural network (ANN-based thermal control method for buildings with double skin envelopes that has rational relationships between the ANN model input and output. The relationship between the indoor air temperature and surrounding environmental factors was investigated based on field measurement data from an actual building. The results imply that the indoor temperature was not significantly influenced by vertical solar irradiance, but by the outdoor and cavity temperature. Accordingly, a new ANN model developed in this study excluded solar irradiance as an input variable for predicting the future indoor temperature. The structure and learning method of this new ANN model was optimized, followed by the performance tests of a variety of internal and external envelope opening strategies for the heating and cooling seasons. The performance tests revealed that the optimized ANN-based logic yielded better temperature conditions than the non-ANN based logic. This ANN-based logic increased overall comfortable periods and decreased the frequency of overshoots and undershoots out of the thermal comfort range. The ANN model proved that it has the potential to be successfully applied in the temperature control logic for double skin-enveloped buildings. The ANN model, which was proposed in this study, effectively predicted future indoor temperatures for the diverse opening strategies. The ANN-based logic optimally determined the operation of heating and cooling systems as well as opening conditions for the double skin envelopes.

  2. Data envelopment analysis model for the appraisal and relative performance evaluation of nurses at an intensive care unit.

    Science.gov (United States)

    Osman, Ibrahim H; Berbary, Lynn N; Sidani, Yusuf; Al-Ayoubi, Baydaa; Emrouznejad, Ali

    2011-10-01

    The appraisal and relative performance evaluation of nurses are very important and beneficial for both nurses and employers in an era of clinical governance, increased accountability and high standards of health care services. They enhance and consolidate the knowledge and practical skills of nurses by identification of training and career development plans as well as improvement in health care quality services, increase in job satisfaction and use of cost-effective resources. In this paper, a data envelopment analysis (DEA) model is proposed for the appraisal and relative performance evaluation of nurses. The model is validated on thirty-two nurses working at an Intensive Care Unit (ICU) at one of the most recognized hospitals in Lebanon. The DEA was able to classify nurses into efficient and inefficient ones. The set of efficient nurses was used to establish an internal best practice benchmark to project career development plans for improving the performance of other inefficient nurses. The DEA result confirmed the ranking of some nurses and highlighted injustice in other cases that were produced by the currently practiced appraisal system. Further, the DEA model is shown to be an effective talent management and motivational tool as it can provide clear managerial plans related to promoting, training and development activities from the perspective of nurses, hence increasing their satisfaction, motivation and acceptance of appraisal results. Due to such features, the model is currently being considered for implementation at ICU. Finally, the ratio of the number DEA units to the number of input/output measures is revisited with new suggested values on its upper and lower limits depending on the type of DEA models and the desired number of efficient units from a managerial perspective.

  3. Thermal Inertia Performance Evaluation of Light-Weighted Construction Space Envelopes Using Phase Change Materials in Mexico City’s Climate

    Directory of Open Access Journals (Sweden)

    Adriana Lira-Oliver

    2017-10-01

    Full Text Available The present study’s main objective was to determine the applicability of organic phase change materials (PCMs in a building’s envelope construction system for the passive provision of comfortable indoor thermal conditions over one year based on thermal inertia in Mexico City. Research on PCMs relate mainly to their use in building envelope construction systems to reduce energy consumption for mechanical indoor thermal conditioning—not in passive systems. Computer simulation results of mean indoor temperature variations are presented with the objective of evaluating these construction systems’ thermal inertia properties. In the present study, dynamic thermal simulations (DTS, using EnergyPlus software, of ten 1 m3 test units with envelope construction systems combining organic PCMs of different fusion temperatures with conventional materials were performed. Based on the results, it is concluded that the implementation of organic PCMs with a fusion temperature around 25 °C in combination with aerated concrete in a space envelope results in the highest number of hours the indoor temperatures remain within the comfort range throughout a typical year, due to the decrement of indoor temperature oscillations and, to a large extent, to thermal lag.

  4. Building Envelope Thermal Performance Assessment Using Visual Programming and BIM, based on ETTV requirement of Green Mark and GreenRE

    Directory of Open Access Journals (Sweden)

    Taki Eddine Seghier

    2017-09-01

    Full Text Available Accomplishment of green building design requirements and the achievement of the targeted credit points under a specific green rating system are known to be a task that is very challenging. Building Information Modeling (BIM design process and tools have already made considerable advancements in green building design and performance analysis. However, Green building design process is still lack of tools and workflows that can provide real-time feedback of building sustainability and rating during the design stage. In this paper, a new workflow of green building design assessment and rating is proposed based on the integration of Visual Programing Language (VPL and BIM. Thus, the aim of this study is to develop a BIM-VPL based tool for building envelope design and assessment support. The focus performance metric in this research is building Envelope Thermal Transfer Value (ETTV which is an Energy Efficiency (EE prerequisite requirement (up to 15 credits in both Green Mark and GreenRE rating systems. The development of the tool begins first by creating a generic integration framework between BIM-VPL functionalities and ETTV requirements. Then, data is extracted from the BIM 3D model and managed using Revit, Excel and Dynamo for visual scripting. A sample project consisting of a hypothetical residential building is run and its envelope ETTV performance and rating score are obtained for the validation of the tool. This tool will support project team in building envelope design and assessment by allowing them to select the most appropriate façade configuration according to its performance efficiency and the green rating. Furthermore, this tool serves as proof of concept that building sustainability rating and compliance checking can be automatically processed through customized workflows developed based on BIM and VPL technologies.

  5. On Innovative Cool-Colored Materials for Building Envelopes: Balancing the Architectural Appearance and the Thermal-Energy Performance in Historical Districts

    Directory of Open Access Journals (Sweden)

    Federica Rosso

    2017-12-01

    Full Text Available Architectural expression and energy performance are key decision-drivers in the selection of a particular construction element, with the purpose of Urban Heat Island mitigation, energy-consumption reductions, and cultural heritage preservation in historical centers. In historical centers, the external layer of the envelope and the visible parts of the building are built with traditional materials and technological solutions, such as single-layer walls or brickworks, depending on the country’s context, while the energy performance is usually optimized by means of internal insulation layers, or other active and passive solutions. Thermal-energy efficient materials and construction elements for the temperate, warm climate of the Mediterranean area are usually light-colored to reflect the largest part of solar radiation, thus reducing energy demands for cooling and improving thermal comfort conditions for occupants. On the other hand, many historical centers in such areas are characterized by reddish or grayish colors. In this work, we considered Italian historical areas, and other countries in the Mediterranean area with present similar situations. Thus, in this study, innovative, cool-colored, cement-based materials were developed to improve the thermal-energy performance of the external envelope of historical/historic built environments, without altering their appearance. These materials were prepared directly on-site, by mixing two types of pigments to achieve the desired color saturation. Optic and thermal properties were assessed, and yearly dynamic simulations of a historic, listed, case study building were performed, by comparing traditional-colored mortar and the prototype cool mortar envelopes. The research demonstrates that such cool-colored materials can maintain lower surface temperatures (−8 °C, while reducing energy demands for cooling (−3%.

  6. Safeguards Envelope Progress FY08

    International Nuclear Information System (INIS)

    Bean, Robert; Metcalf, Richard; Bevill, Aaron

    2008-01-01

    The Safeguards Envelope Project met its milestones by creating a rudimentary safeguards envelope, proving the value of the approach on a small scale, and determining the most appropriate path forward. The Idaho Chemical Processing Plant's large cache of reprocessing process monitoring data, dubbed UBER Data, was recovered and used in the analysis. A probabilistic Z test was used on a Markov Monte Carlo simulation of expected diversion data when compared with normal operating data. The data regarding a fully transient event in a tank was used to create a simple requirement, representative of a safeguards envelope, whose impact was a decrease in operating efficiency by 1.3% but an increase in material balance period of 26%. This approach is operator, state, and international safeguards friendly and should be applied to future reprocessing plants. Future requirements include tank-to-tank correlations in reprocessing facilities, detailed operations impact studies, simulation inclusion, automated optimization, advanced statistics analysis, and multi-attribute utility analysis

  7. Integrating dynamic fuzzy C-means, data envelopment analysis and artificial neural network to online prediction performance of companies in stock exchange

    Science.gov (United States)

    Jahangoshai Rezaee, Mustafa; Jozmaleki, Mehrdad; Valipour, Mahsa

    2018-01-01

    One of the main features to invest in stock exchange companies is their financial performance. On the other hand, conventional evaluation methods such as data envelopment analysis are not only a retrospective process, but are also a process, which are incomplete and ineffective approaches to evaluate the companies in the future. To remove this problem, it is required to plan an expert system for evaluating organizations when the online data are received from stock exchange market. This paper deals with an approach for predicting the online financial performance of companies when data are received in different time's intervals. The proposed approach is based on integrating fuzzy C-means (FCM), data envelopment analysis (DEA) and artificial neural network (ANN). The classical FCM method is unable to update the number of clusters and their members when the data are changed or the new data are received. Hence, this method is developed in order to make dynamic features for the number of clusters and clusters members in classical FCM. Then, DEA is used to evaluate DMUs by using financial ratios to provide targets in neural network. Finally, the designed network is trained and prepared for predicting companies' future performance. The data on Tehran Stock Market companies for six consecutive years (2007-2012) are used to show the abilities of the proposed approach.

  8. Data envelopment analysis with upper bound on output to measure efficiency performance of departments in Malaikulsaleh University

    Science.gov (United States)

    Abdullah, Dahlan; Suwilo, Saib; Tulus; Mawengkang, Herman; Efendi, Syahril

    2017-09-01

    The higher education system in Indonesia can be considered not only as an important source of developing knowledge in the country, but also could create positive living conditions for the country. Therefore it is not surprising that enrollments in higher education continue to expand. However, the implication of this situation, the Indonesian government is necessarily to support more funds. In the interest of accountability, it is essential to measure the efficiency for this higher institution. Data envelopment analysis (DEA) is a method to evaluate the technical efficiency of production units which have multiple input and output. The higher learning institution considered in this paper is Malikussaleh University located in Lhokseumawe, a city in Aceh province of Indonesia. This paper develops a method to evaluate efficiency for all departments in Malikussaleh University using DEA with bounded output. Accordingly, we present some important differences in efficiency of those departments. Finally we discuss the effort should be done by these departments in order to become efficient.

  9. Enveloping Aerodynamic Decelerator

    Science.gov (United States)

    Nock, Kerry T. (Inventor); Aaron, Kim M. (Inventor); McRonald, Angus D. (Inventor); Gates, Kristin L. (Inventor)

    2018-01-01

    An inflatable aerodynamic deceleration method and system is provided for use with an atmospheric entry payload. The inflatable aerodynamic decelerator includes an inflatable envelope and an inflatant, wherein the inflatant is configured to fill the inflatable envelope to an inflated state such that the inflatable envelope surrounds the atmospheric entry payload, causing aerodynamic forces to decelerate the atmospheric entry payload.

  10. Investigating Performance Installation of Hospital Room Surgery of Six Hospitals in Special Region of Yogyakarta by Using Data Envelopment Analysis Model Constant Return to Scale

    Directory of Open Access Journals (Sweden)

    Bhimo Rizky Samudro

    2018-03-01

    Full Text Available This study aims to investigate the efficiency level of hospital surgery hospital installation in Special Region of Yogyakarta Province. Research conceptual constructs are based on input and output performance in institutional performance processes. This research approach uses positivist pattern and is derived by quantitative method. This is to explain the efficiency pattern of the installation of hospital and private hospital surgery rooms. The quantitative method chosen is the concept of Data Envelopment Analysis (DEA. The results showed that 1 the installation of a private hospital surgery room tends to be more efficient than government property; 2 the installation of a special hospital surgical hospital is not absolutely more efficient than a public hospital. As a recommendation, this research provides scenario for setting input usage for efficient performance.

  11. N-Back auditory test performance in normal individuals

    Directory of Open Access Journals (Sweden)

    Vanessa Tomé Gonçalves

    Full Text Available Abstract The working memory construct refers to the capacity to maintain information for a limited time. Objectives: To devise stimuli and adapt the 5-back test and to verify the effect of age in normal Brazilian individuals. Methods: 31 healthy adults (15 young adults and 16 older adults were evaluated by batteries of auditory stimuli to verify the inter-group differences (age effect in working memory span, total correct answers and intrusions, and the intra-group effect of type of stimulus. Results: There was no intra-group stimulus effect. Individuals from both groups processed di and tri-syllables similarly. No difference between groups (no age effect was observed for any N-Back parameters: total score, span, number of intrusions, in either di or tri-syllable presentation. Conclusion: the processing capacity of 5 elements in phonological working memory was not affected by age.

  12. WAIS Performance in Unincarcerated Groups of MMPI-Defined Sociopaths and Normal Controls

    Science.gov (United States)

    Allain, Albert N.

    1974-01-01

    This investigation examines WAIS performance in groups of 32 sociopaths and 33 normal controls defined by Minnesota Multiphasic Personality Inventory criteria. Sociopaths and normal controls show no differences in overall level of intellectual functioning. (Author)

  13. Relation between temporal envelope coding, pitch discrimination, and compression estimates in listeners with sensorineural hearing loss

    DEFF Research Database (Denmark)

    Bianchi, Federica; Santurette, Sébastien; Fereczkowski, Michal

    2015-01-01

    Recent physiological studies in animals showed that noise-induced sensorineural hearing loss (SNHL) increased the amplitude of envelope coding in single auditory-nerve fibers. The present study investigated whether SNHL in human listeners was associated with enhanced temporal envelope coding...... resolvability. For the unresolved conditions, all five HI listeners performed as good as or better than NH listeners with matching musical experience. Two HI listeners showed lower amplitude-modulation detection thresholds than NH listeners for low modulation rates, and one of these listeners also showed a loss......, whether this enhancement affected pitch discrimination performance, and whether loss of compression following SNHL was a potential factor in envelope coding enhancement. Envelope processing was assessed in normal-hearing (NH) and hearing-impaired (HI) listeners in a behavioral amplitude...

  14. Performance evaluation and ranking of participation Asian countries in 2012 London Olympic Games through Data Envelopment Analysis

    Directory of Open Access Journals (Sweden)

    Hadi Shirouyehzad

    2014-07-01

    Full Text Available The Olympic Games ranking is done through lexicographic multi criteria method in each period. According to this method, the country receiving the most gold medals will have the highest score, and in case of having equal silver medals, comparison will be done according to bronze ones. The problem of this method is to pay the most attention merely to gold medals. Using data envelopment analysis, some studies have recently suggested various ranking for the Olympic Games. The present research uses DEA to rank the participating Asian countries in London Olympic that have at least won one medal. As an output-oriented BCC model, this one considers the number of male and female athletes, received medals in two previous Olympic as well as the number of their presence in the Olympic games as the inputs. Gold, silver and bronze medals are the only output of the model. This model is solved in two forms of female and male athlete combination and their separation. Solving this model makes this opportunity to present a new rankings model for participating Asian countries in the Olympic Games that can be compared with the ranking used by Olympic committee.

  15. Analysis of WWER-440 fuel performance under normal operating conditions

    Energy Technology Data Exchange (ETDEWEB)

    Gunduz, Oe; Koese, S; Akbas, T [Atomenerjisi Komisyonu, Ankara (Turkey); Colak, Ue [Ankara Nuclear Research and Training Center (Turkey)

    1994-12-31

    FRAPCON-2 code originally developed for LWR fuel behaviour simulation is used to analyse the WWER-440 fuel rod behaviour at normal operational conditions. The code is capable of utilizing different models for mechanical analysis and gas release calculations. Heat transfer calculations are accomplished through a collocation technique by the method of weighted residuals. Temperature and burnup element properties are evaluated using MATPRO package. As the material properties of Zr-1%Nb used as cladding in WWER-440s are not provided in the code, Zircaloy-4 is used as a substitute for Zr-1%Nb. Mac-Donald-Weisman model is used for gas release calculation. FRACAS-1 and FRACAS-2 models are used in the mechanical calculations. It is assumed that the reactor was operated for 920 days (three consecutive cycles), the burnup being 42000 Mwd/t U. Results of the fuel rod behaviour analysis are given for three axial nodes: bottom node, central node and top node. The variations of the following characteristic fuel rod parameters are studied through the prescribed power history: unmoved gap thickness, gap heat transfer coefficient, fuel axial elongation, cladding axial elongation, fuel centerline temperature and ZrO-thickness at cladding surface. The value of each parameter is calculated as a function of the effective power days for the three nodes by using FRACAS-1 and FRACAS-2 codes for comparison.The results show that calculations with deformable pellet approximation with FRACAS-II model could provide better information for the behaviour of a typical fuel rod. Calculations indicate that fuel rod failure is not observed during the operation. All fuel rod parameters investigated are found to be within the safety limits. It is concluded, however, that for better assessment of reactor safety these calculations should be extended for transient conditions such as LOCA. 1 tab., 10 figs., 4 refs.

  16. ECOENVELOPES R&D. Passive architectural envelopes high thermal performance and low environmental impact for tropical geoclimatic zones

    Directory of Open Access Journals (Sweden)

    Varini, C.

    2013-09-01

    Full Text Available “Ecoenvelopes” is about the development of building envelope solutions for tropical humid climates involving passive control of thermal gains on their surfaces, allowing for better internal conditions and comfort without the use of thermal machines. Environmental principles, design, and technological aspects are specifically defined based on the peculiar conditions (geo-climatic, technological, of biodiversity, economic and anthropic present in the Colombian low altitude regions, marked by constant high temperatures. Thermal and CFD simulations orient the process of experimental verification in a permanent laboratory counting on partnerships and available know-how.“Ecoenvolventes” plantea el desarrollo de soluciones de envolventes arquitectónicas para clima tropical húmedo, que permiten el control pasivo de las ganancias térmicas en sus superficies permitiendo el mejoramiento de las condiciones internas e generar condiciones de confort sin el uso de máquinas térmicas. Principios, diseño, tecnologías y aspectos medioambientales son expresamente definidos en función de las peculiares condiciones (e.i. geo-climáticas, tecnológicas, de biodiversidad, económicas y antrópicas presentes en las regiones colombianas con baja altitud, caracterizadas por altas temperaturas a lo largo de todo el año. Simulaciones térmicas y CFD orientan el proceso de verificación experimental en un laboratorio permanente contando con convenios con empresas locales y know-how disponible in situ.

  17. Moisture dynamics in building envelopes

    Energy Technology Data Exchange (ETDEWEB)

    Peuhkuri, R.

    2003-07-01

    The overall scope of this Thesis 'Moisture dynamics in building envelopes' has been to characterise how the various porous insulation materials investigated performed hygro thermally under conditions similar to those in a typical building envelope. As a result of the changing temperature and moisture conditions in the exterior weather and indoor climate the materials dynamically absorb and release moisture. The complexity of the impact of these conditions on the resulting moisture transport and content of the materials has been studied in this Thesis with controlled laboratory tests. (au)

  18. Moisture Dynamics in Building Envelopes

    DEFF Research Database (Denmark)

    Peuhkuri, Ruut Hannele

    2003-01-01

    The overall scope of this Thesis "Moisture dynamics in building envelopes" has been to characterise how the various porous insulation materials investigated performed hygrothermally under conditions similar to those in a typical building envelope. As a result of the changing temperature...... part of the Thesis consists of a theory and literature review on the moisture storage and transport processes (Chapter 2), on the non-Fickian moisture transport (Chapter 3)and on the methods for determining the moisture properties (Chapter 4). In the second part, the conducted experimental work...

  19. Comparing and contrasting poverty reduction performance of social welfare programs across jurisdictions in Canada using Data Envelopment Analysis (DEA): an exploratory study of the era of devolution.

    Science.gov (United States)

    Habibov, Nazim N; Fan, Lida

    2010-11-01

    In the mid-1990s, the responsibilities to design, implement, and evaluate social welfare programs were transferred from federal to local jurisdictions in many countries of North America and Europe through devolution processes. Devolution has caused the need for a technique to measure and compare the performances of social welfare programs across multiple jurisdictions. This paper utilizes Data Envelopment Analysis (DEA) for a comparison of poverty reduction performances of jurisdictional social welfare programs across Canadian provinces. From the theoretical perspective, findings of this paper demonstrates that DEA is a promising method to evaluate, compare, and benchmark poverty reduction performance across multiple jurisdictions using multiple inputs and outputs. This paper demonstrates that DEA generates easy to comprehend composite rankings of provincial performances, identifies appropriate benchmarks for each inefficient province, and estimates sources and amounts of improvement needed to make the provinces efficient. From a practical perspective the empirical results presented in this paper indicate that Newfoundland, Prince Edwards Island, and Alberta achieve better efficiency in poverty reduction than other provinces. Policy makers and social administrators of the ineffective provinces across Canada may find benefit in selecting one of the effective provinces as a benchmark for improving their own performance based on similar size and structure of population, size of the budget for social programs, and traditions with administering particular types of social programs. Copyright (c) 2009 Elsevier Ltd. All rights reserved.

  20. Diffusion-weighted MRI in prostatic lesions: Diagnostic performance of normalized ADC using normal peripheral prostatic zone as a reference

    Directory of Open Access Journals (Sweden)

    Tamer F. Taha Ali

    2018-03-01

    Full Text Available Aim of study: Evaluate the potential value of the normal peripheral zone as a reference organ to normalize prostatic lesion apparent diffusion coefficient (ADC to improve its evaluation of prostatic lesions. Patients and methods: This prospective study included 38 patients with clinical suspicion of cancer prostate (increased PSA levels (>4 ng/ml, hard prostate in digital rectal examination and who are scheduled to undergo a TRUS-guided biopsy. Conventional and DW-MRI was done and ADC was calculated. The normalized ADC value was calculated by dividing the ADC of lesion by ADC of reference site (healthy peripheral zone. DWI-MRI results were compared to the results of biopsy. Comparison of ADCs and nADCs of benign and malignant lesions was done. Receiver operating characteristics (ROC curve analysis was done. Results: The patients were classified by histopathology into non-malignant group (16 patients and malignant group (22 patients. Significant negative correlation between ADC and normalized ADC (nADC and malignancy was detected. There was no significant difference between the mean ADC of peripheral health prostatic zones (PZ between benign and malignant cases (2.221 ± 0.356 versus 1.99 ± 0.538x10−3 mm2/sec, p = 0.144.There was significant difference between the mean ADC and mean nADC in benign and malignant lesions (1.049 ± 0.217 versus 0.659 ± 0.221x10−3 mm2/sec, p < 0.001 and (0.475 ± 0.055 versus 0.328 ± 0.044, p < 0.001 respectively.There was significant higher diagnostic performance of nADC than ADC with ADC Cut-off value 0.75 × 10−3 mm2/sec and nADC cut-off value 0.39 could significantly differentiate between benign and malignant lesion with sensitivity, specificity, PPV,NPV of 86.36,75,82.61 and 80% respectively, p < 0.0001 for ADC and 95.45, 93.75, 95.45 and 93.75%, p < 0.0001 for nADC. Conclusion: diagnostic performance of nADC using normal peripheral zone is higher than

  1. Storage envelopes or sleeves

    International Nuclear Information System (INIS)

    Freshwater, J.R.; Wagman, P.I.

    1980-01-01

    A storage envelope or sleeve particularly for processed X-ray films is described. It consists of front and back panels joined together at a hinge line and connected along the intermediate sides by connecting flaps. An inner pocket is formed from a third flap which is folded to lie against the inner face of the back panel. The panels may have additional score lines parallel to the closed sides of the envelope and the inner pocket so that the envelope and the inner pocket can accommodate bulky contents. The free edge of the pocket is inset from the open side of the envelope, and finger cut-outs may be provided to facilitate access to the contents of the envelope and the pocket. (author)

  2. Investigating the Financial Performance of Universities of Medical Science and Health Services in Iran, Using Data Envelopment Analysis.

    Science.gov (United States)

    Nasiripour, Amir Ashkan; Toloie-Ashlaghy, Abbas; Ta-Bibi, Seyed Jamaleddin; Maleki, Mohammad Reza; Gorji, Hassan Abolghasem

    2014-01-01

    Universities of Medical Science and Health Services (UMSHSs) are among the main organizations in Iran's health-care section. Improving their efficiency in financial resource management through creating an appropri-ate coordination between consumption and resources is strategically vital. Investigating the financial performance as well as ranking the Iranian UMSHSs is the research objective. The study is of descriptive and applied type. The study population includes the UMSHSs of Iran (n=42) among which 24 UMSHSs are selected. DEA is used with the aim to model and assess the financial performance in-cluding 4 inputs and 3 outputs. Also, linear regression is applied to determine the effectiveness of the applied indices as well as the level of the financial performance. Data are obtained from the Budgeting Center in the Ministry of Health and Medical Education, during 2010 mainly through forms designed based on the available balance sheets. The average score of financial performance assessment for UMSHSs based on the DEA of input-oriented data is 0.74, assuming a constant scale of DEA-CRS. Thus, approximately 25% of the studied UMSHSs have maxi-mum relative performance and totally, there is about a 30% capacity to increase the financial performance in these UMSHSs. Most Iranian UMSHSs do not have high financial performance. This can be due to problems in financial resource management especially in asset combining. Therefore, compilation and execution of a comprehensive pro-gram for organizational change and agility with the aim to create a kind of optimized combination of resources and assets is strongly recommended.

  3. 14 CFR 29.87 - Height-velocity envelope.

    Science.gov (United States)

    2010-01-01

    ... Category A engine isolation requirements, the height-velocity envelope for complete power failure must be... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Height-velocity envelope. 29.87 Section 29... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Flight Performance § 29.87 Height-velocity envelope. (a...

  4. Protective plasma envelope

    International Nuclear Information System (INIS)

    Bocharov, V.N.; Konstantinov, S.G.; Kudryavtsev, A.M.; Myskin, O.K.; Panasyuk, V.M.; Tsel'nik, F.A.

    1984-06-01

    A method of creating an annular plasma envelope used to protect the hot plasma from flows of impurities and gases from the walls of the vacuum chamber is described. The diameter of the envelope is 30 cm, the thickness of the wall is 1.5 cm, the length is 2.5 m, and its density is from 10 13 to 10 14 cm -3 . The envelope attenuates the incident (from outside) flow of helium 10-fold and the low of hydrogen 20-fold

  5. Safeguards Envelope Progress FY08

    Energy Technology Data Exchange (ETDEWEB)

    Robert Bean; Richard Metcalf; Aaron Bevill

    2008-09-01

    The Safeguards Envelope Project met its milestones by creating a rudimentary safeguards envelope, proving the value of the approach on a small scale, and determining the most appropriate path forward. The Idaho Chemical Processing Plant’s large cache of reprocessing process monitoring data, dubbed UBER Data, was recovered and used in the analysis. A probabilistic Z test was used on a Markov Monte Carlo simulation of expected diversion data when compared with normal operating data. The data regarding a fully transient event in a tank was used to create a simple requirement, representative of a safeguards envelope, whose impact was a decrease in operating efficiency by 1.3% but an increase in material balance period of 26%. This approach is operator, state, and international safeguards friendly and should be applied to future reprocessing plants. Future requirements include tank-to-tank correlations in reprocessing facilities, detailed operations impact studies, simulation inclusion, automated optimization, advanced statistics analysis, and multi-attribute utility analysis.

  6. Primacy Performance of Normal and Retarded Children: Stimulus Familiarity or Spatial Memory?

    Science.gov (United States)

    Swanson, Lee

    1978-01-01

    Explores the effect of stimulus familiarity on the spatial primacy performance of normal and retarded children. Assumes that serial recall tasks reflect spatial memory rather than verbal rehearsal. (BD)

  7. Safe operating envelope

    Energy Technology Data Exchange (ETDEWEB)

    Oliva, N [Ontario Hydro, Toronto, ON (Canada)

    1997-12-01

    Safe Operating Envelope is described representing: The outer bound of plant conditions within which day-to-day plant operation must be maintained in order to comply with regulatory requirements, associated safety design criteria and corporate nuclear safety goals. Figs.

  8. Safe operating envelope

    International Nuclear Information System (INIS)

    Oliva, N.

    1997-01-01

    Safe Operating Envelope is described representing: The outer bound of plant conditions within which day-to-day plant operation must be maintained in order to comply with regulatory requirements, associated safety design criteria and corporate nuclear safety goals. Figs

  9. On self-propagating methodological flaws in performance normalization for strength and power sports.

    Science.gov (United States)

    Arandjelović, Ognjen

    2013-06-01

    Performance in strength and power sports is greatly affected by a variety of anthropometric factors. The goal of performance normalization is to factor out the effects of confounding factors and compute a canonical (normalized) performance measure from the observed absolute performance. Performance normalization is applied in the ranking of elite athletes, as well as in the early stages of youth talent selection. Consequently, it is crucial that the process is principled and fair. The corpus of previous work on this topic, which is significant, is uniform in the methodology adopted. Performance normalization is universally reduced to a regression task: the collected performance data are used to fit a regression function that is then used to scale future performances. The present article demonstrates that this approach is fundamentally flawed. It inherently creates a bias that unfairly penalizes athletes with certain allometric characteristics, and, by virtue of its adoption in the ranking and selection of elite athletes, propagates and strengthens this bias over time. The main flaws are shown to originate in the criteria for selecting the data used for regression, as well as in the manner in which the regression model is applied in normalization. This analysis brings into light the aforesaid methodological flaws and motivates further work on the development of principled methods, the foundations of which are also laid out in this work.

  10. Cardiorespiratory performance and physical activity in normal weight and overweight Finnish adolescents from 2003 to 2010.

    Science.gov (United States)

    Palomäki, Sanna; Heikinaro-Johansson, Pilvikki; Huotari, Pertti

    2015-01-01

    We investigated changes in cardiorespiratory performance, BMI and leisure-time physical activity among Finnish adolescents from 2003 to 2010. In addition, we compared cardiorespiratory performance levels between normal weight and overweight adolescents, grouped according to their physical activity. Participants were a national representative samples of 15-16-year-old adolescents in their final (ninth) year of comprehensive school in 2003 (n = 2258) and in 2010 (n = 1301). They performed an endurance shuttle run test and reported their height and weight and leisure time physical activity on a questionnaire. Results showed no significant secular changes in cardiorespiratory performance from 2003 to 2010. The mean BMI increased in boys. Leisure-time physical activity increased among normal weight girls. Adolescents of normal weight had better cardiorespiratory performance than those classified as overweight at both assessment points. BMI-adjusted physical activity was a significant determinant for cardiorespiratory performance among overweight adolescents, and very active overweight adolescents had similar cardiorespiratory performance levels as moderately active adolescents of normal weight. The results of the present study support the idea that the physical activity has the great importance for the cardiorespiratory performance in adolescents. Overweight adolescents, in particular, benefit from higher levels of physical activity.

  11. The Best and the Rest: Revisiting the Norm of Normality of Individual Performance

    Science.gov (United States)

    O'Boyle, Ernest, Jr.; Aguinis, Herman

    2012-01-01

    We revisit a long-held assumption in human resource management, organizational behavior, and industrial and organizational psychology that individual performance follows a Gaussian (normal) distribution. We conducted 5 studies involving 198 samples including 633,263 researchers, entertainers, politicians, and amateur and professional athletes.…

  12. HIV-1 envelope glycoprotein

    Science.gov (United States)

    Caulfield, Michael; Cupo, Albert; Dean, Hansi; Hoffenberg, Simon; King, C. Richter; Klasse, P. J.; Marozsan, Andre; Moore, John P.; Sanders, Rogier W.; Ward, Andrew; Wilson, Ian; Julien, Jean-Philippe

    2017-08-22

    The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization, electron microscopy and other biophysical, biochemical and immunological studies for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions, which are formulated into the vaccines of the present invention.

  13. Common envelope evolution

    NARCIS (Netherlands)

    Taam, Ronald E.; Ricker, Paul M.

    2010-01-01

    The common envelope phase of binary star evolution plays a central role in many evolutionary pathways leading to the formation of compact objects in short period systems. Using three dimensional hydrodynamical computations, we review the major features of this evolutionary phase, focusing on the

  14. Off-normal performance of EBR-II [Experimental Breeder Reactor] driver fuel

    International Nuclear Information System (INIS)

    Seidel, B.R.; Batte, G.L.; Lahm, C.E.; Fryer, R.M.; Koenig, J.F.; Hofman, G.L.

    1986-09-01

    The off-normal performance of EBR-II Mark-II driver fuel has been more than satisfactory as demonstrated by robust reliability under repeated transient overpower and undercooled loss-of-flow tests, by benign run-beyond-cladding-breach behavior, and by forgiving response to fabrication defects including lack of bond. Test results have verified that the metallic driver fuel is very tolerant of off-normal events. This behavior has allowed EBR-II to operate in a combined steady-state and transient mode to provide test capability without limitation from the metallic driver fuel

  15. (Quasi-)Poisson enveloping algebras

    OpenAIRE

    Yang, Yan-Hong; Yao, Yuan; Ye, Yu

    2010-01-01

    We introduce the quasi-Poisson enveloping algebra and Poisson enveloping algebra for a non-commutative Poisson algebra. We prove that for a non-commutative Poisson algebra, the category of quasi-Poisson modules is equivalent to the category of left modules over its quasi-Poisson enveloping algebra, and the category of Poisson modules is equivalent to the category of left modules over its Poisson enveloping algebra.

  16. Thermal Activated Envelope

    DEFF Research Database (Denmark)

    Foged, Isak Worre; Pasold, Anke

    2015-01-01

    The research studies the making of a responsive architectural envelope based on bi-materials. The bi-materials are organized according to a method that combines different isotropic metals and plastic into an active composite structure that reacts to temperature variations. Through an evolutionary......, environmental dynamics and occupancy dynamics. Lastly, a physical prototype is created, which illustrates the physical expression of the bi-materials and the problems related to manufacturing of these composite structures.......The research studies the making of a responsive architectural envelope based on bi-materials. The bi-materials are organized according to a method that combines different isotropic metals and plastic into an active composite structure that reacts to temperature variations. Through an evolutionary...

  17. The performance of a novel flat heat pipe based thermal and PV/T (photovoltaic and thermal systems) solar collector that can be used as an energy-active building envelope material

    International Nuclear Information System (INIS)

    Jouhara, H.; Milko, J.; Danielewicz, J.; Sayegh, M.A.; Szulgowska-Zgrzywa, M.; Ramos, J.B.; Lester, S.P.

    2016-01-01

    A novel flat heat pipe design has been developed and utilised as a building envelope and thermal solar collector with and without (PV) bonded directly to its surface. The design of the new solar collector has been validated through full scale testing in Cardiff, UK where solar/thermal, uncooled PV and PV/T tests were carried out on three identical systems, simultaneously. The tests showed a solar/thermal energy conversion efficiency of around 64% for the collector with no PV and 50% for the system with the PV layer on it. The effect of cooling on the solar/electrical energy conversion efficiency was also investigated and an efficiency increase of about 15% was recorded for the cooled PV system due to the provided homogenous cooling. The new flat heat pipe solar collector is given the name “heat mat” and, in addition to being an efficient solar collector type, it is also designed to convert a building envelope materials to become energy-active. A full size roof that utilise this new building envelope material is reported in this paper to demonstrate the way this new collector is integrated as a building envelope material to form a roof. A thermal absorption test, in a controlled environment, from the ambient to the heat mat with no solar radiation is also reported. The test has proved the heat mat as an efficient thermal absorber from the ambient to the intermediate fluid that deliver the heat energy to the heat pump system. - Highlights: • A new flat heat pipe PV/T system that can be used as building materials is reported. • The new solar collector enhanced the performance of the PV by about 15%. • The new solar collector is capable of absorbing heat from ambient efficiently. • The new system is efficient from the solar/thermal conversion point of view.

  18. Identification and quantification of amino acids from psoriatic and normal epidermis by high performance liquid chromatography

    International Nuclear Information System (INIS)

    Mahesar, S.M.; Khuhawar, M.Y.

    2010-01-01

    In this study, a modified fluorescence technique high performance liquid chromatography (HPLC) was adapted to separate the amino acids from the hydrolyzed keratin samples. These samples obtained from the epidermal layer of the normal and psoriatic human subjects. The keratin extracts are quantified in gram percentage of the dried skin and the amino acids concentrations are measured in mu g/g, mean retention time (tR), slope value and the coefficient of determination (r2) of each eluted amino acid is calculated. The coefficients of variation for amino acid standards ranged from 0.12% to 0.28%, mean, standard deviation of peak area and coefficients of variation of peak area were calculated. From the normal hydrolysated keratin protein fraction, 12 amino acids were determined and identified as aspartic acid, glutamic acid, asparagines, serine, glutamine, glycine, histidine, citrulline, arganine, fi-alanine, tyrosine, and valine. These amino acids were also determined in psoriatic samples while standard deviations (SD), standard error mean (SEM) and coefficient variation (CV%) of normal and psoriatic samples were also calculated. The higher concentration of amino acids in normal samples against psoriatic samples determined as glutamic acid 92.76+- 16. 83/50. 87+-9.88, glutamine 198.05+-18.74/19.74+-3.74 while higher concentrations of amino acids determined in psoriatic samples against normal samples as asparagines 81. 06+-10+-10.62/29. 98+-3.641; arganine 164.42+-35. 11/46. 14+-46, tyrosine 214.38+-29. 61/59. 64+-8. 82, and valine 169.7+-19.35/128.06+-15.14.1 is concluded that the absolute concentration of amino acids in psoriatic skin indicated a number of variations as compared to normal skin samples. (author)

  19. How age affects memory task performance in clinically normal hearing persons.

    Science.gov (United States)

    Vercammen, Charlotte; Goossens, Tine; Wouters, Jan; van Wieringen, Astrid

    2017-05-01

    The main objective of this study is to investigate memory task performance in different age groups, irrespective of hearing status. Data are collected on a short-term memory task (WAIS-III Digit Span forward) and two working memory tasks (WAIS-III Digit Span backward and the Reading Span Test). The tasks are administered to young (20-30 years, n = 56), middle-aged (50-60 years, n = 47), and older participants (70-80 years, n = 16) with normal hearing thresholds. All participants have passed a cognitive screening task (Montreal Cognitive Assessment (MoCA)). Young participants perform significantly better than middle-aged participants, while middle-aged and older participants perform similarly on the three memory tasks. Our data show that older clinically normal hearing persons perform equally well on the memory tasks as middle-aged persons. However, even under optimal conditions of preserved sensory processing, changes in memory performance occur. Based on our data, these changes set in before middle age.

  20. Featured Image: Orbiting Stars Share an Envelope

    Science.gov (United States)

    Kohler, Susanna

    2016-03-01

    This beautiful series of snapshots from a simulation (click for a better look!) shows what happens when two stars in a binary system become enclosed in the same stellar envelope. In this binary system, one of the stars has exhausted its hydrogen fuel and become a red giant, complete with an expanding stellar envelope composed of hydrogen and helium. Eventually, the envelope expands so much that the companion star falls into it, where it releases gravitational potential energy into the common envelope. A team led by Sebastian Ohlmann (Heidelberg Institute for Theoretical Studies and University of Wrzburg) recently performed hydrodynamic simulations of this process. Ohlmann and collaborators discovered that the energy release eventually triggers large-scale flow instabilities, which leads to turbulence within the envelope. This process has important consequences for how these systems next evolve (for instance, determining whether or not a supernova occurs!). You can check out the authors video of their simulated stellar inspiral below, or see their paper for more images and results from their study.CitationSebastian T. Ohlmann et al 2016 ApJ 816 L9. doi:10.3847/2041-8205/816/1/L9

  1. Safeguards Envelope Progress FY10

    International Nuclear Information System (INIS)

    Metcalf, Richard

    2010-01-01

    The Safeguards Envelope is a strategy to determine a set of specific operating parameters within which nuclear facilities may operate to maximize safeguards effectiveness without sacrificing safety or plant efficiency. This paper details the additions to the advanced operating techniques that will be applied to real plant process monitoring (PM) data from the Idaho Chemical Processing Plant (ICPP). Research this year focused on combining disparate pieces of data together to maximize operating time with minimal downtime due to safeguards. A Chi-Square and Croiser's cumulative sum were both included as part of the new analysis. Because of a major issue with the original data, the implementation of the two new tests did not add to the existing set of tests, though limited one-variable optimization made a small increase in detection probability. Additional analysis was performed to determine if prior analysis would have caused a major security or safety operating envelope issue. It was determined that a safety issue would have resulted from the prior research, but that the security may have been increased under certain conditions.

  2. Visual determinants of reduced performance on the Stroop color-word test in normal aging individuals.

    Science.gov (United States)

    van Boxtel, M P; ten Tusscher, M P; Metsemakers, J F; Willems, B; Jolles, J

    2001-10-01

    It is unknown to what extent the performance on the Stroop color-word test is affected by reduced visual function in older individuals. We tested the impact of common deficiencies in visual function (reduced distant and close acuity, reduced contrast sensitivity, and color weakness) on Stroop performance among 821 normal individuals aged 53 and older. After adjustment for age, sex, and educational level, low contrast sensitivity was associated with more time needed on card I (word naming), red/green color weakness with slower card 2 performance (color naming), and reduced distant acuity with slower performance on card 3 (interference). Half of the age-related variance in speed performance was shared with visual function. The actual impact of reduced visual function may be underestimated in this study when some of this age-related variance in Stroop performance is mediated by visual function decrements. It is suggested that reduced visual function has differential effects on Stroop performance which need to be accounted for when the Stroop test is used both in research and in clinical settings. Stroop performance measured from older individuals with unknown visual status should be interpreted with caution.

  3. Uncertain data envelopment analysis

    CERN Document Server

    Wen, Meilin

    2014-01-01

    This book is intended to present the milestones in the progression of uncertain Data envelopment analysis (DEA). Chapter 1 gives some basic introduction to uncertain theories, including probability theory, credibility theory, uncertainty theory and chance theory. Chapter 2 presents a comprehensive review and discussion of basic DEA models. The stochastic DEA is introduced in Chapter 3, in which the inputs and outputs are assumed to be random variables. To obtain the probability distribution of a random variable, a lot of samples are needed to apply the statistics inference approach. Chapter 4

  4. Normalized Point Source Sensitivity for Off-Axis Optical Performance Evaluation of the Thirty Meter Telescope

    Science.gov (United States)

    Seo, Byoung-Joon; Nissly, Carl; Troy, Mitchell; Angeli, George

    2010-01-01

    The Normalized Point Source Sensitivity (PSSN) has previously been defined and analyzed as an On-Axis seeing-limited telescope performance metric. In this paper, we expand the scope of the PSSN definition to include Off-Axis field of view (FoV) points and apply this generalized metric for performance evaluation of the Thirty Meter Telescope (TMT). We first propose various possible choices for the PSSN definition and select one as our baseline. We show that our baseline metric has useful properties including the multiplicative feature even when considering Off-Axis FoV points, which has proven to be useful for optimizing the telescope error budget. Various TMT optical errors are considered for the performance evaluation including segment alignment and phasing, segment surface figures, temperature, and gravity, whose On-Axis PSSN values have previously been published by our group.

  5. What Limits Cardiac Performance during Exercise in Normal Subjects and in Healthy Fontan Patients?

    Directory of Open Access Journals (Sweden)

    André La Gerche

    2010-01-01

    Full Text Available Exercise is an important determinant of health but is significantly reduced in the patient with a univentricular circulation. Normal exercise physiology mandates an increase in pulmonary artery pressures which places an increased work demand on the right ventricle (RV. In a biventricular circulation with pathological increases in pulmonary vascular resistance and/or reductions in RV function, exercise-induced augmentation of cardiac output is limited. Left ventricular preload reserve is dependent upon flow through the pulmonary circulation and this requires adequate RV performance. In the Fontan patient, the reasons for exercise intolerance are complex. In those patients with myocardial dysfunction or other pathologies of the circulatory components, it is likely that these abnormalities serve as a limitation to cardiac performance during exercise. However, in the healthy Fontan patient, it may be the absence of a sub-pulmonary pump which limits normal increases in pulmonary pressures, trans-pulmonary flow requirements and cardiac output. If so, performance will be exquisitely dependent on pulmonary vascular resistance. This provides a potential explanation as to why pulmonary vasodilators may improve exercise tolerance. As has recently been demonstrated, these agents may offer an important new treatment strategy which directly addresses the physiological limitations in the Fontan patient.

  6. Normalized performance and load data for the deepwind demonstrator in controlled conditions

    DEFF Research Database (Denmark)

    Battisti, L.; Benini, E.; Brighenti, A.

    2016-01-01

    , derived from real scale measurements on a three-bladed Troposkien vertical-axis wind turbine, are manipulated in a convenient form to be easily compared with the typical outputs provided by simulation codes. The here proposed data complement and support the measurements already presented in "Wind Tunnel......Performance and load normalized coefficients, deriving from an experimental campaign of measurements conducted at the large scale wind tunnel of the Politecnico di Milano (Italy), are presented with the aim of providing useful benchmark data for the validation of numerical codes. Rough data...... Testing of the DeepWind Demonstrator in Design and Tilted Operating Conditions" (Battisti et al., 2016) [1]....

  7. Physical self-perception and motor performance in normal-weight, overweight and obese children.

    Science.gov (United States)

    Morano, M; Colella, D; Robazza, C; Bortoli, L; Capranica, L

    2011-06-01

    The aim of this study was to examine the relationships among physical self-perception, body image and motor performance in Italian middle school students. Two hundred and sixty children were categorized into normal-weight (n=103), overweight (n=86) or obese (n=71) groups. Perceived coordination, body fat and sports competence were assessed using the Physical Self-Description Questionnaire, while body image was measured using Collins' Child Figure Drawings. Individuals' perceptions of strength, speed and agility were assessed using the Perceived Physical Ability Scale. Tests involving the standing long jump, 2 kg medicine-ball throw, 10 × 5 m shuttle-run and 20 and 30 m sprints were also administered. Girls, when compared with boys, and overweight and obese participants, when compared with normal-weight peers, reported lower perceived and actual physical competence, higher perceived body fat and greater body dissatisfaction. Body dissatisfaction mediated all the associations between body mass index (BMI) and the different aspects of physical self-perception in boys, but not in girls. The same pattern of results was found for physical self-perception as a mediator of the relationship between BMI and body dissatisfaction. In conclusion, obesity proved to have adverse effects on both motor performance and physical self-perception. © 2010 John Wiley & Sons A/S.

  8. Normal weight children have higher cognitive performance - Independent of physical activity, sleep, and diet.

    Science.gov (United States)

    Hjorth, Mads F; Sørensen, Louise B; Andersen, Rikke; Dyssegaard, Camilla B; Ritz, Christian; Tetens, Inge; Michaelsen, Kim F; Astrup, Arne; Egelund, Niels; Sjödin, Anders

    2016-10-15

    Aside from the health consequences, observational studies indicate that being overweight may also negatively affect cognitive function. However, existing evidence has to a large extent not controlled for the possible confounding effect of having different lifestyles. Therefore, the objective was to examine the independent associations between weight status and lifestyle indicators with cognitive performance in 8-11year old Danish children. The analyses included 828 children (measured in 2011-2012) each having one to three measurement occasions separated by approximately 100days. Dietary intake, physical activity, sedentary time, and sleep duration were measured using dietary records and accelerometers. The Children's Sleep Habits Questionnaire was used to access sleep problems and the Andersen test was carried out to estimate cardio-respiratory fitness (CRF). Weight status (underweight, normal weight, and overweight/obese) was defined according to body mass index and cognitive performance was assessed using the d2-test of attention, a reading test, and a math test. A linear mixed model including a number of fixed and random effects was used to test associations between lifestyle indicators as well as BMI category and cognitive performance. After adjustment for demographics, socioeconomics, and multiple lifestyle indicators, normal weight children had higher cognitive test scores than overweight/obese and underweight children of up to 89% and 48% of expected learning within one school year (Pbreakfast consumption, fewer sleep problems, higher CRF, less total physical activity, more sedentary time, and less light physical activity were associated with higher cognitive performance independently of each other in at least one of the three cognitive tests (Pperformance compared to overweight/obese as well as underweight children, independent of multiple lifestyle indicators. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Full waveform inversion using envelope-based global correlation norm

    Science.gov (United States)

    Oh, Ju-Won; Alkhalifah, Tariq

    2018-05-01

    To increase the feasibility of full waveform inversion on real data, we suggest a new objective function, which is defined as the global correlation of the envelopes of modelled and observed data. The envelope-based global correlation norm has the advantage of the envelope inversion that generates artificial low-frequency information, which provides the possibility to recover long-wavelength structure in an early stage. In addition, the envelope-based global correlation norm maintains the advantage of the global correlation norm, which reduces the sensitivity of the misfit to amplitude errors so that the performance of inversion on real data can be enhanced when the exact source wavelet is not available and more complex physics are ignored. Through the synthetic example for 2-D SEG/EAGE overthrust model with inaccurate source wavelet, we compare the performance of four different approaches, which are the least-squares waveform inversion, least-squares envelope inversion, global correlation norm and envelope-based global correlation norm. Finally, we apply the envelope-based global correlation norm on the 3-D Ocean Bottom Cable (OBC) data from the North Sea. The envelope-based global correlation norm captures the strong reflections from the high-velocity caprock and generates artificial low-frequency reflection energy that helps us recover long-wavelength structure of the model domain in the early stages. From this long-wavelength model, the conventional global correlation norm is sequentially applied to invert for higher-resolution features of the model.

  10. SSRI effects on pyschomotor performance: assessment of citalopram and escitalopram on normal subjects.

    Science.gov (United States)

    Paul, Michel A; Gray, Gary W; Love, Ryan J; Lange, Marvin

    2007-07-01

    Standard aeromedical doctrine dictates that aircrew receiving treatment for depression are grounded during treatment and follow-up observation, generally amounting to at least 1 yr. The Canadian Forces has initiated a program to return selected aircrew being treated for depression to restricted flying duties once stabilized on an approved antidepressant with resolution of depression. The currently approved medications are sertraline (a selective serotonin reuptake inhibitor) and bupropion (noradrenaline and dopamine reuptake inhibitor). This study was undertaken to determine whether or not citalopram or escitalopram affect psychomotor performance. In a double-blind crossover protocol with counter-balanced treatment order, 24 normal volunteer subjects (14 men and 10 women) were assessed for psychomotor performance during placebo, citalopram (40 mg), and escitalopram (20 mg) treatment. Each treatment arm lasted 2 wk, involving a daily morning ingestion of one capsule. There was a 1-wk washout period between medication courses. Subjects completed a drug side-effect questionnaire and were tested on three psychomotor test batteries once per week. Neither citalopram nor escitalopram affected serial reaction time, logical reasoning, serial subtraction, multitask, or MacWorth clock task performance. While we found some of the expected side effects due to citalopram and escitalopram, there was no impact on psychomotor performance. These findings support the possibility of using citalopram and escitalopram for returning aircrew to restricted flight duties (non-tactical flying) under close observation as a maintenance treatment after full resolution of depression.

  11. Cognitive levels of performance account for hemispheric lateralisation effects in dyslexic and normally reading children.

    Science.gov (United States)

    Heim, Stefan; Grande, Marion; Meffert, Elisabeth; Eickhoff, Simon B; Schreiber, Helen; Kukolja, Juraj; Shah, Nadim Jon; Huber, Walter; Amunts, Katrin

    2010-12-01

    Recent theories of developmental dyslexia explain reading deficits in terms of deficient phonological awareness, attention, visual and auditory processing, or automaticity. Since dyslexia has a neurobiological basis, the question arises how the reader's proficiency in these cognitive variables affects the brain regions involved in visual word recognition. This question was addressed in two fMRI experiments with 19 normally reading children (Experiment 1) and 19 children with dyslexia (Experiment 2). First, reading-specific brain activation was assessed by contrasting the BOLD signal for reading aloud words vs. overtly naming pictures of real objects. Next, ANCOVAs with brain activation during reading the individuals' scores for all five cognitive variables assessed outside the scanner as covariates were performed. Whereas the normal readers' brain activation during reading showed co-variation effects predominantly in the right hemisphere, the reverse pattern was observed for the dyslexics. In particular, middle frontal gyrus, inferior parietal cortex, and precuneus showed contralateral effects for controls as compared to dyslexics. In line with earlier findings in the literature, these data hint at a global change in hemispheric asymmetry during cognitive processing in dyslexic readers, which, in turn, might affect reading proficiency. Copyright © 2010 Elsevier Inc. All rights reserved.

  12. A correlational method to concurrently measure envelope and temporal fine structure weights: effects of age, cochlear pathology, and spectral shaping.

    Science.gov (United States)

    Fogerty, Daniel; Humes, Larry E

    2012-09-01

    The speech signal may be divided into spectral frequency-bands, each band containing temporal properties of the envelope and fine structure. This study measured the perceptual weights for the envelope and fine structure in each of three frequency bands for sentence materials in young normal-hearing listeners, older normal-hearing listeners, aided older hearing-impaired listeners, and spectrally matched young normal-hearing listeners. The availability of each acoustic property was independently varied through noisy signal extraction. Thus, the full speech stimulus was presented with noise used to mask six different auditory channels. Perceptual weights were determined by correlating a listener's performance with the signal-to-noise ratio of each acoustic property on a trial-by-trial basis. Results demonstrate that temporal fine structure perceptual weights remain stable across the four listener groups. However, a different weighting typography was observed across the listener groups for envelope cues. Results suggest that spectral shaping used to preserve the audibility of the speech stimulus may alter the allocation of perceptual resources. The relative perceptual weighting of envelope cues may also change with age. Concurrent testing of sentences repeated once on a previous day demonstrated that weighting strategies for all listener groups can change, suggesting an initial stabilization period or susceptibility to auditory training.

  13. Normalized performance and load data for the deepwind demonstrator in controlled conditions

    Directory of Open Access Journals (Sweden)

    L. Battisti

    2016-09-01

    Full Text Available Performance and load normalized coefficients, deriving from an experimental campaign of measurements conducted at the large scale wind tunnel of the Politecnico di Milano (Italy, are presented with the aim of providing useful benchmark data for the validation of numerical codes. Rough data, derived from real scale measurements on a three-bladed Troposkien vertical-axis wind turbine, are manipulated in a convenient form to be easily compared with the typical outputs provided by simulation codes. The here proposed data complement and support the measurements already presented in “Wind Tunnel Testing of the DeepWind Demonstrator in Design and Tilted Operating Conditions” (Battisti et al., 2016 [1]. Keywords: VAWT, DeepWind Project, Troposkien rotor, Skewed flow, Wind tunnel measurements, Wind turbine benchmark data

  14. Structural performance of a multipurpose canister shell for HLNW under normal handling conditions

    International Nuclear Information System (INIS)

    Ladkany, S.G.; Rajagopalan, R.

    1994-01-01

    A Multipurpose Canister (MPC) is analyzed for critical stresses that occur during normal handling conditions and accidental scenarios. Linear and Non-linear Finite Element Analysis is performed and the stresses at various critical locations in the MPC and its weldments are studied extensively. Progressive failure analysis of the MPC's groove and fillet welds, is presented. The structural response of the MPC to dynamic lifting loads, to loads resulting from an accidental slippage of a crane cable carrying the MPC, and from the impact between two canisters, is evaluated. Nonlinear structural analysis is used in the evaluation of the local buckling and the ultimate failure phenomena in the shell when the steel is in the strain hardening state during impact. Results make a case for increasing the thickness of the shell and all the welds

  15. Caffeine effects on learning, performance, and anxiety in normal school-age children.

    Science.gov (United States)

    Bernstein, G A; Carroll, M E; Crosby, R D; Perwien, A R; Go, F S; Benowitz, N L

    1994-01-01

    The purpose of this investigation was to study the acute effects of caffeine on learning, performance, and anxiety in normal prepubertal children. Twenty-one children were evaluated in a double-blind, placebo-controlled crossover design. Subjects were studied during four sessions, 1 week apart, under the following conditions: baseline, placebo, 2.5 mg/kg caffeine, and 5.0 mg/kg caffeine. Subjects were randomized to order of placebo and the two dosages of caffeine. Dependent measures included tests of attention, manual dexterity, short-term memory, and processing speed. Anxiety rating scales were also administered. Saliva samples were analyzed for caffeine levels. Caffeine improved performance on two of four measures of the Test of Variables of Attention and on a test of manual dexterity in the dominant hand. There was a trend toward increased current level of self-reported anxiety after caffeine on a visual analogue measure of anxiety. Children reported feeling significantly less "sluggish" after caffeine ingestion than after placebo ingestion. In a small sample size, there was indication that caffeine enhanced performance on a test of attention and on a motor task. Children also reported feeling less "sluggish" but somewhat more anxious. Because caffeine is so widely available and frequently consumed by children, these results are important and need replication.

  16. Performance analysis of MIMO wireless optical communication system with Q-ary PPM over correlated log-normal fading channel

    Science.gov (United States)

    Wang, Huiqin; Wang, Xue; Lynette, Kibe; Cao, Minghua

    2018-06-01

    The performance of multiple-input multiple-output wireless optical communication systems that adopt Q-ary pulse position modulation over spatial correlated log-normal fading channel is analyzed in terms of its un-coded bit error rate and ergodic channel capacity. The analysis is based on the Wilkinson's method which approximates the distribution of a sum of correlated log-normal random variables to a log-normal random variable. The analytical and simulation results corroborate the increment of correlation coefficients among sub-channels lead to system performance degradation. Moreover, the receiver diversity has better performance in resistance of spatial correlation caused channel fading.

  17. Drinking game participation, gender performance and normalization of intoxication among Nigerian university students.

    Science.gov (United States)

    Dumbili, Emeka; Williams, Clare

    2017-06-01

    Most research on drinking games (DGs) and the associated risks focuses on Western countries. In the Nigerian context, DGs activity has not attracted scholarly attention but growing media reports indicate that Nigerian youths play DGs, and that a number of gamers have died during or immediately after game-playing. Drawing on gender performance scripts, we explored the performance of gender through DGs practices and the factors that motivate DGs participation. Thirty-one in-depth interviews were conducted with male and female college students (aged 19-23 years) at a university in south-eastern Nigeria. The participants discussed the popularity of the DGs that students play on this campus, identifying the spaces where each game is played and the motivations for game-playing. Collective, contextual constructions of gender identities through 'Fastest-Drinker' DG were identified, and the participants also performed gender through 'Truth-or-Dare' and 'Endurance' DGs. Men dominated 'First-to-Finish' DGs, which are played at parties and bars, and consumed beer or stout, while women, who mainly played Truth-or-Dare games, drank spirits or sweetened alcoholic beverages. Boredom and fun seeking provoked game-playing among women while adherence to masculinity norms, which engendered the public performance of masculinity and gambling activities, motivated men to play DGs. To avoid 'collective shame', men's friendship groups provided support/care for inebriated game-playing members, but the immediacy of this support/care varied according to DGs type. DGs appear to normalize heavy drinking and the culture of intoxication on this campus. Measures to monitor alcohol sales outlets around campuses and interventions that target students' leisure spaces should be developed.

  18. Influence of age on left ventricular performance during exercise in normal Japanese subject

    International Nuclear Information System (INIS)

    Konishi, Tokuji; Koyama, Takao; Aoki, Toshikazu; Makino, Katsutoshi; Yamamuro, Masashi; Nakai, Kyudayu; Nakamura, Masayuki; Nakano, Takeshi.

    1990-01-01

    To assess the effects of age on left ventricular performance, multistage supine ergometer exercise radionuclide ventriculography (RNV) was performed in 92 normal subjects. The subjects ranged in age from 24 to 86 years and were free of cardiopulmonary disease and diabetes. Age-related changes in exercise duration, left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), cardiac output (CO) left ventricular ejection fraction (LVEF), left ventricular dv/dt, systolic and diastolic time indexes of dv/dt, and peak systolic pressure/left ventricular end-systolic volume (PSP/LVESV) were analyzed at rest and during the peak exercise stage. Age-related decrease in LVEDV and peak diastolic dv/dt were significant at rest. The time indexes of ECG R to peak systolic dv/dt and time of end-systole to peak diastolic dv/dt also were prolonged with age. Both maximum heart rate and exercise duration were shown to decline with age. No age-related difference was observed in LVESV, LVEF or PSP/LVESV either at rest or during exercise. However, the change of LVEF and LVESV during exercise was less in subjects aged 60 or more. These results indicate decreased left ventricular function during exercise in elderly subjects. (author)

  19. FREC-4A: a computer program to predict fuel rod performance under normal reactor operation

    International Nuclear Information System (INIS)

    Harayama, Yasuo; Izumi, Fumio

    1981-10-01

    The program FREC-4A (Fuel Reliability Evaluation Code-version 4A) is used for predicting fuel rod performance in normal reactor operation. The performance is calculated in accordance with the irradiation history of fuel rods. Emphasis is placed on the prediction of the axial elongation of claddings induced by pellet-cladding mechanical interaction, including the influence of initially preloaded springs inserted in fuel rod lower plenums. In the FREC-4A, an fuel rod is divided into axial segments. In each segment, it is assumed that the temperature, stress and strain are axi-symmetrical, and the axial strain in constant in fuel pellets and in a cladding, though the values in the pellets and in the cladding are different. The calculation of the contact load and the clearance along the length of a fuel rod and the stress and strain in each segment is explained. The method adopted in the FREC-4A is simple, and suitable to predict the deformation of fuel rods over their full length. This report is described on the outline of the program, the method of solving the stiffness equations, the calculation models, the input data such as irradiation history, output distribution, material properties and pores, the printing-out of input data and calculated results. (Kako, I.)

  20. Depressive Symptom Clusters and Neuropsychological Performance in Mild Alzheimer's and Cognitively Normal Elderly

    Directory of Open Access Journals (Sweden)

    James R. Hall

    2011-01-01

    Full Text Available Objectives. Determine the relationship between depressive symptom clusters and neuropsychological test performance in an elderly cohort of cognitively normal controls and mild Alzheimer's disease (AD. Design. Cross-sectional analysis. Setting. Four health science centers in Texas. Participants. 628 elderly individuals (272 diagnosed with mild AD and 356 controls from ongoing longitudinal study of Alzheimer's disease. Measurements. Standard battery of neuropsychological tests and the 30-item Geriatric Depression Scale with regressions model generated on GDS-30 subscale scores (dysphoria, apathy, meaninglessness and cognitive impairment as predictors and neuropsychological tests as outcome variables. Follow-up analyses by gender were conducted. Results. For AD, all symptom clusters were related to specific neurocognitive domains; among controls apathy and cognitive impairment were significantly related to neuropsychological functioning. The relationship between performance and symptom clusters was significantly different for males and females in each group. Conclusion. Findings suggest the need to examine disease status and gender when considering the impact of depressive symptoms on cognition.

  1. Effects of sex and normal aging on regional brain activation during verbal memory performance

    Science.gov (United States)

    Hazlett, Erin A.; Byne, William; Brickman, Adam M.; Mitsis, Effie M.; Newmark, Randall; Haznedar, M. Mehmet; Knatz, Danielle T.; Chen, Amy D.; Buchsbaum, Monte S.

    2010-01-01

    This study examined the main and interactive effects of age and sex on relative glucose metabolic rate (rGMR) within gray matter of 39 cortical Brodmann areas (BAs) and the cingulate gyrus using 18FDG-PET during a verbal memory task in 70 healthy normal adults, aged 20–87 years. Women showed significantly greater age-related rGMR decline in left cingulate gyrus than men (BAs 25, 24, 23, 31, 29). Both groups showed a decline in the anterior cingulate—a neuroanatomical structure that mediates effective cognitive-emotional interactions (BAs 32, 24, 25), while the other frontal regions did not show substantial decline. No sex differences in rGMR were identified within temporal, parietal and occipital lobes. Sex differences were observed for rGMR within subcomponents of the cingulate gyrus with men higher in BA25 and BA29, but lower in BA24 and BA 23 compared to women. For men, better memory performance was associated with greater rGMR in BA24, whereas in women better performance was associated with orbitofrontal-BA12. These results suggest that both age-related metabolic decline and sex differences within frontal regions are more marked in medial frontal and cingulate areas, consistent with some age-related patterns of affective and cognitive change. PMID:19027195

  2. A novel murmur-based heart sound feature extraction technique using envelope-morphological analysis

    Science.gov (United States)

    Yao, Hao-Dong; Ma, Jia-Li; Fu, Bin-Bin; Wang, Hai-Yang; Dong, Ming-Chui

    2015-07-01

    Auscultation of heart sound (HS) signals serves as an important primary approach to diagnose cardiovascular diseases (CVDs) for centuries. Confronting the intrinsic drawbacks of traditional HS auscultation, computer-aided automatic HS auscultation based on feature extraction technique has witnessed explosive development. Yet, most existing HS feature extraction methods adopt acoustic or time-frequency features which exhibit poor relationship with diagnostic information, thus restricting the performance of further interpretation and analysis. Tackling such a bottleneck problem, this paper innovatively proposes a novel murmur-based HS feature extraction method since murmurs contain massive pathological information and are regarded as the first indications of pathological occurrences of heart valves. Adapting discrete wavelet transform (DWT) and Shannon envelope, the envelope-morphological characteristics of murmurs are obtained and three features are extracted accordingly. Validated by discriminating normal HS and 5 various abnormal HS signals with extracted features, the proposed method provides an attractive candidate in automatic HS auscultation.

  3. Relating Memory To Functional Performance In Normal Aging to Dementia Using Hierarchical Bayesian Cognitive Processing Models

    Science.gov (United States)

    Shankle, William R.; Pooley, James P.; Steyvers, Mark; Hara, Junko; Mangrola, Tushar; Reisberg, Barry; Lee, Michael D.

    2012-01-01

    Determining how cognition affects functional abilities is important in Alzheimer’s disease and related disorders (ADRD). 280 patients (normal or ADRD) received a total of 1,514 assessments using the Functional Assessment Staging Test (FAST) procedure and the MCI Screen (MCIS). A hierarchical Bayesian cognitive processing (HBCP) model was created by embedding a signal detection theory (SDT) model of the MCIS delayed recognition memory task into a hierarchical Bayesian framework. The SDT model used latent parameters of discriminability (memory process) and response bias (executive function) to predict, simultaneously, recognition memory performance for each patient and each FAST severity group. The observed recognition memory data did not distinguish the six FAST severity stages, but the latent parameters completely separated them. The latent parameters were also used successfully to transform the ordinal FAST measure into a continuous measure reflecting the underlying continuum of functional severity. HBCP models applied to recognition memory data from clinical practice settings accurately translated a latent measure of cognition to a continuous measure of functional severity for both individuals and FAST groups. Such a translation links two levels of brain information processing, and may enable more accurate correlations with other levels, such as those characterized by biomarkers. PMID:22407225

  4. THE CONSTRUCTIVE RELATIONSHIP BETWEEN ACCOUNTING AND PERFORMANCE IN THE CONTEXT OF CORPORATE GOVERNANCE AND ACCOUNTING NORMALIZATION

    Directory of Open Access Journals (Sweden)

    Mihai SAVIN

    2014-05-01

    Full Text Available Since the emergence of the concept of corporate governance, there was a close connection between this concept and accounting, which is enforced by the fact that the latter must reflect, in a conventional manner, all the economic facts that affect the economic entity, meaning the facts related to the production, distribution and consumption of wealth, but also to the creation of value for shareholders and other stakeholders, in this sense being the most reliable, efficient and effective method of economic observation. The explanations provided by the economic science according to which an economic entity is considered an individual agent who seeks to maximize profits no longer constitute a support for explaining the continental, renan or Anglo-Saxon accounting model, and as such the scientific basis of accounting must be seeked in the scientific approach of the concept of corporate governance, which has as overall objective the study of the manner to lead, to steer, to structure, to develop, to control an entity (company, public institution etc., to create value for shareholders and other interest groups. Corporate governance and also the normalization of the accounting have managed for the first time to provide a complete and consistent representation of the economic entity, meaning they defined the essential tools to manage and control the economic activity, to measure its overall performance.

  5. Exercise left ventricular performance in patients with chest pain, ischemic-appearing exercise electrocardiograms, and angiographically normal coronary arteries

    International Nuclear Information System (INIS)

    Berger, H.J.; Sands, M.J.; Davies, R.A.; Wackers, F.J.; Alexander, J.; Lachman, A.S.; Williams, B.W.; Zaret, B.L.

    1981-01-01

    Left ventricular performance was evaluated using first-pass radionuclide angiocardiography in 31 patients with chest pain, an ischemic-appearing exercise electrocardiogram, and angiographically normal coronary arteries at rest and during maximal upright bicycle exercise. 201 Tl imaging was done in all patients after treadmill exercise and in selected patients after ergonovine provocation. Resting left ventricular performance was normal in all patients. An abnormal ejection fraction response to exercise was detected in 12 of 31 patients. Regional dysfunction was present during exercise in four patients, all of whom also had abnormal global responses. Three of these 12 patients and two additional patients had exercise-induced 201 Tl perfusion defects. In all nine patients who underwent ergonovine testing, there was no suggestion of coronary arterial spasm. Thus, left ventricular dysfunction during exercise, in the presence of normal resting performance, was found in a substantial number of patients with chest pain, an ischemic-appearing exercise electrocardiogram, and normal coronary arteries

  6. The LHC on an envelope

    CERN Multimedia

    2007-01-01

    The series of envelopes featuring CERN issued this summer was a huge success. The French postal services of the Pays de Gex will shortly be launching the second set of pre-paid envelopes issued in collaboration with the Laboratory this year, this time highlighting the LHC. Five thousand envelopes describing the accelerator’s capabilities will go on sale on 12 November, and some of the packs will even contain a small sample of the cables from the heart of the LHC magnets. The sets of ten pre-paid envelopes will tell you everything about CERN’s flagship accelerator, from its astounding technical capabilities to its spin-offs in the fields of technology and human resources. Each envelope will feature a different attribute or spin-off of the LHC. People will be invited to consult CERN’s public website for more detailed explanations if they want to know more. The new envelopes will be available from five post offices in the Pays ...

  7. The LHC in an envelope

    CERN Multimedia

    2007-01-01

    The series of envelopes featuring CERN issued this summer was a huge success. The French postal services of the Pays de Gex will shortly be launching the second set of pre-paid envelopes issued in collaboration with the Laboratory this year, this time highlighting the LHC. Five thousand envelopes describing the accelerator’s capabilities will go on sale on 12 November, and some of the packs will even contain a small sample of the cables from the heart of the LHC magnets. The sets of ten pre-paid envelopes will tell you everything about CERN’s flagship accelerator, from its astounding technical capabilities to its spin-offs in the fields of technology and human resources. Each envelope will feature a different attribute or spin-off of the LHC. People will be invited to consult CERN’s public website for more detailed explanations if they want to know more. The new envelopes will be available from five post offices in the Pays de Gex (Ferney-Voltaire, Prévessin...

  8. Is the performance of acceleromyography improved with preload and normalization? A comparison with mechanomyography

    DEFF Research Database (Denmark)

    Claudius, Casper; Skovgaard, Lene Theil; Viby-Mogensen, Jørgen

    2009-01-01

    to mechanomyography during recovery (e.g., from 0.15 to 0.05 at TOF 0.90); when the mechanomyographic TOF values were normalized as well, the bias was eliminated. However, normalization did not exclude wide individual differences between acceleromyography and mechanomyography (+/- 0.10-0.20 at TOF 0.90). CONCLUSION...

  9. Intelligent building envelopes. Architectural concept and applications for daylighting quality

    Energy Technology Data Exchange (ETDEWEB)

    Wyckmans, Annemie

    2005-11-15

    How does an intelligent building envelope manage the variable and sometimes conflictive occupant requirements that arise in a day lit indoor environment. This is the research question that provides the basis for this Ph.D. work. As it touches upon several fields of application, the research question is untangled into four steps, each of which corresponds to a chapter of the thesis. 1) What characterises intelligent behaviour for a building envelope. 2) What characterises indoor day lighting quality. 3) Which functions can an intelligent building envelope be expected to perform in the context of day lighting quality. 4) How are the materials, components and composition of an intelligent building envelope designed to influence this performance. The emphasis is on design, environmental aspects, energy conservation, functional analysis and physical applications.

  10. Performance of brain-damaged, schizophrenic, and normal subjects on a visual searching task.

    Science.gov (United States)

    Goldstein, G; Kyc, F

    1978-06-01

    Goldstein, Rennick, Welch, and Shelly (1973) reported on a visual searching task that generated 94.1% correct classifications when comparing brain-damaged and normal subjects, and 79.4% correct classifications when comparing brain-damaged and psychiatric patients. In the present study, representing a partial cross-validation with some modification of the test procedure, comparisons were made between brain-damaged and schizophrenic, and brain-damaged and normal subjects. There were 92.5% correct classifications for the brain-damaged vs normal comparison, and 82.5% correct classifications for the brain-damaged vs schizophrenic comparison.

  11. Shape Control of Responsive Building Envelopes

    DEFF Research Database (Denmark)

    Foged, Isak Worre; Kirkegaard, Poul Henning; Christensen, Jesper Thøger

    2010-01-01

    The present paper considers shape control of adaptive architectural structures for improvement of structural performance by recognizing changes in their environments and loads, adapting to meet goals, and using past events to improve future performance or maintain serviceability. The general scop...... environmental system to a primary structural system joint into a collective behavioral system equipment with an actuator system is presented....... alternatives. The adaptive structure is a proposal for a responsive building envelope which is an idea of a first level operational framework for present and future investigations towards performance based responsive architectures through a set of responsive typologies. A mock-up concept of a secondary...

  12. Drinking game participation, gender performance and normalization of intoxication among Nigerian university students

    Directory of Open Access Journals (Sweden)

    Emeka Dumbili

    2017-06-01

    Conclusion: DGs appear to normalize heavy drinking and the culture of intoxication on this campus. Measures to monitor alcohol sales outlets around campuses and interventions that target students' leisure spaces should be developed.

  13. Digital image envelope: method and evaluation

    Science.gov (United States)

    Huang, H. K.; Cao, Fei; Zhou, Michael Z.; Mogel, Greg T.; Liu, Brent J.; Zhou, Xiaoqiang

    2003-05-01

    Health data security, characterized in terms of data privacy, authenticity, and integrity, is a vital issue when digital images and other patient information are transmitted through public networks in telehealth applications such as teleradiology. Mandates for ensuring health data security have been extensively discussed (for example The Health Insurance Portability and Accountability Act, HIPAA) and health informatics guidelines (such as the DICOM standard) are beginning to focus on issues of data continue to be published by organizing bodies in healthcare; however, there has not been a systematic method developed to ensure data security in medical imaging Because data privacy and authenticity are often managed primarily with firewall and password protection, we have focused our research and development on data integrity. We have developed a systematic method of ensuring medical image data integrity across public networks using the concept of the digital envelope. When a medical image is generated regardless of the modality, three processes are performed: the image signature is obtained, the DICOM image header is encrypted, and a digital envelope is formed by combining the signature and the encrypted header. The envelope is encrypted and embedded in the original image. This assures the security of both the image and the patient ID. The embedded image is encrypted again and transmitted across the network. The reverse process is performed at the receiving site. The result is two digital signatures, one from the original image before transmission, and second from the image after transmission. If the signatures are identical, there has been no alteration of the image. This paper concentrates in the method and evaluation of the digital image envelope.

  14. Aspherical Dust Envelopes Around Oxygen-Rich AGB Stars

    Directory of Open Access Journals (Sweden)

    Kyung-Won Suh

    2006-12-01

    Full Text Available We model the aspherical dust envelopes around O-rich AGB stars. We perform the radiative transfer model calculations for axisymmetric dust distributions. We simulate what could be observed from the aspherical dust envelopes around O-rich AGB stars by presenting the model spectral energy distributions and images at various wavelengths for different optical depths and viewing angles. The model results are very different from the ones with spherically symmetric geometry.

  15. Used Nuclear Fuel Loading and Structural Performance Under Normal Conditions of Transport- Demonstration of Approach and Results on Used Fuel Performance Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Adkins, Harold [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Geelhood, Ken [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Koeppel, Brian [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Coleman, Justin [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bignell, John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Flores, Gregg [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Wang, Jy-An [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Sanborn, Scott [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Spears, Robert [Idaho National Lab. (INL), Idaho Falls, ID (United States); Klymyshyn, Nick [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2013-09-30

    This document addresses Oak Ridge National Laboratory milestone M2FT-13OR0822015 Demonstration of Approach and Results on Used Nuclear Fuel Performance Characterization. This report provides results of the initial demonstration of the modeling capability developed to perform preliminary deterministic evaluations of moderate-to-high burnup used nuclear fuel (UNF) mechanical performance under normal conditions of storage (NCS) and normal conditions of transport (NCT) conditions. This report also provides results from the sensitivity studies that have been performed. Finally, discussion on the long-term goals and objectives of this initiative are provided.

  16. Envelope enhancement increases cortical sensitivity to interaural envelope delays with acoustic and electric hearing.

    Directory of Open Access Journals (Sweden)

    Douglas E H Hartley

    Full Text Available Evidence from human psychophysical and animal electrophysiological studies suggests that sensitivity to interaural time delay (ITD in the modulating envelope of a high-frequency carrier can be enhanced using half-wave rectified stimuli. Recent evidence has shown potential benefits of equivalent electrical stimuli to deaf individuals with bilateral cochlear implants (CIs. In the current study we assessed the effects of envelope shape on ITD sensitivity in the primary auditory cortex of normal-hearing ferrets, and profoundly-deaf animals with bilateral CIs. In normal-hearing animals, cortical sensitivity to ITDs (±1 ms in 0.1-ms steps was assessed in response to dichotically-presented i sinusoidal amplitude-modulated (SAM and ii half-wave rectified (HWR tones (100-ms duration; 70 dB SPL presented at the best-frequency of the unit over a range of modulation frequencies. In separate experiments, adult ferrets were deafened with neomycin administration and bilaterally-implanted with intra-cochlear electrode arrays. Electrically-evoked auditory brainstem responses (EABRs were recorded in response to bipolar electrical stimulation of the apical pair of electrodes with singe biphasic current pulses (40 µs per phase over a range of current levels to measure hearing thresholds. Subsequently, we recorded cortical sensitivity to ITDs (±800 µs in 80-µs steps within the envelope of SAM and HWR biphasic-pulse trains (40 µs per phase; 6000 pulses per second, 100-ms duration over a range of modulation frequencies. In normal-hearing animals, nearly a third of cortical neurons were sensitive to envelope-ITDs in response to SAM tones. In deaf animals with bilateral CI, the proportion of ITD-sensitive cortical neurons was approximately a fifth in response to SAM pulse trains. In normal-hearing and deaf animals with bilateral CI the proportion of ITD sensitive units and neural sensitivity to ITDs increased in response to HWR, compared with SAM stimuli

  17. Data envelopment analysis - DEA and fuzzy sets to assess the performance of academic departments: a case study at Federal University of Santa Catarina - UFSC

    Directory of Open Access Journals (Sweden)

    Lopes Ana Lúcia Miranda

    2002-01-01

    Full Text Available This paper address the issue of performance evaluation - productivity and quality - of academic departments at an University. A DEA model was used to simulate a process of cross-evaluation between departments. The results of DEA in the dimensions of teaching, research, service and quality were modeled as fuzzy numbers and then aggregated through a weighted ordered aggregator. A single index of performance for each department was generated. The proposal is to identify departments with low performance in one or more dimensions that should receive additional evaluation from an external auditing committee. A by-product of the model is to enlarge the possibility of working with more variables than a conventional DEA model. The model applied to a set of fifty-eight departments of a Brazilian University showed fifteen with low performance. Zero correlation between department teaching, research and service were observed. Weak correlation was detected between research productivity and quality. Weak scale effects were detected.

  18. Investigating Performance Installation of Hospital Room Surgery of Six Hospitals in Special Region of Yogyakarta by Using Data Envelopment Analysis Model Constant Return to Scale

    OpenAIRE

    Bhimo Rizky Samudro; Yogi Pasca Pratama

    2018-01-01

    This study aims to investigate the efficiency level of hospital surgery hospital installation in Special Region of Yogyakarta Province. Research conceptual constructs are based on input and output performance in institutional performance processes. This research approach uses positivist pattern and is derived by quantitative method. This is to explain the efficiency pattern of the installation of hospital and private hospital surgery rooms. The quantitative method chosen is the concept of Dat...

  19. Envelope Protection for In-Flight Ice Contamination

    Science.gov (United States)

    Gingras, David R.; Barnhart, Billy P.; Ranaudo, Richard J.; Ratvasky, Thomas P.; Morelli, Eugene A.

    2010-01-01

    Fatal loss-of-control (LOC) accidents have been directly related to in-flight airframe icing. The prototype system presented in this paper directly addresses the need for real-time onboard envelope protection in icing conditions. The combinations of a-priori information and realtime aerodynamic estimations are shown to provide sufficient input for determining safe limits of the flight envelope during in-flight icing encounters. The Icing Contamination Envelope Protection (ICEPro) system has been designed and implemented to identify degradations in airplane performance and flying qualities resulting from ice contamination and provide safe flight-envelope cues to the pilot. Components of ICEPro are described and results from preliminary tests are presented.

  20. Building Envelope Thermal Performance Assessment Using Visual Programming and BIM, based on ETTV requirement of Green Mark and GreenRE

    OpenAIRE

    Taki Eddine Seghier; Lim Yaik Wah; Mohd Hamdan Ahmad; Williams Opeyemi Samuel

    2017-01-01

    Accomplishment of green building design requirements and the achievement of the targeted credit points under a specific green rating system are known to be a task that is very challenging. Building Information Modeling (BIM) design process and tools have already made considerable advancements in green building design and performance analysis. However, Green building design process is still lack of tools and workflows that can provide real-time feedback of building sustainability and rating du...

  1. A Look at the Memory Performance of Retarded and Normal Children Utilizing the Levels of Processing Framework.

    Science.gov (United States)

    Lupart, Judy L.; Mulcahy, Robert F.

    Memory performance differences of mental age matched (9-12 years) educable mentally retarded (EMR) (n=56) and normal (n=56) children were examined in two experiments using the F. Craik and R. Lockhart levels of processing framework. In experiment 1, Ss were randomly assigned to an incidental, intentional, or planned intentional learning condition,…

  2. Mathematical model and computer code for coated particles performance at normal operating conditions

    International Nuclear Information System (INIS)

    Golubev, I.; Kadarmetov, I.; Makarov, V.

    2002-01-01

    Computer modeling of thermo-mechanical behavior of coated particles during operating both at normal and off-normal conditions has a very significant role particularly on a stage of new reactors development. In Russia a big experience has been accumulated on fabrication and reactor tests of CP and fuel elements with UO 2 kernels. However, this experience cannot be using in full volume for development of a new reactor installation GT-MHR. This is due to very deep burn-up of the fuel based on plutonium oxide (up to 70% fima). Therefore the mathematical modeling of CP thermal-mechanical behavior and failure prediction becomes particularly important. The authors have a clean understanding that serviceability of fuel with high burn-ups are defined not only by thermo-mechanics, but also by structured changes in coating materials, thermodynamics of chemical processes, 'amoeba-effect', formation CO etc. In the report the first steps of development of integrate code for numerical modeling of coated particles behavior and some calculating results concerning the influence of various design parameters on fuel coated particles endurance for GT-MHR normal operating conditions are submitted. A failure model is developed to predict the fraction of TRISO-coated particles. In this model it is assumed that the failure of CP depends not only on probability of SiC-layer fracture but also on the PyC-layers damage. The coated particle is considered as a uniform design. (author)

  3. Pushing the Envelope

    DEFF Research Database (Denmark)

    Azawi, Nessn H; Christensen, Tom; Dahl, Claus

    2018-01-01

    PURPOSE OF REVIEW: The purposes of this review were to identify the possible limiting factors prohibiting laparoscopic nephrectomy being performed as an outpatient surgery and optimize these limiting factors. RECENT FINDINGS: Laparoscopic nephrectomy for patients who have kidney cancer can be per...

  4. Nature of 'unseen' galactic envelopes

    International Nuclear Information System (INIS)

    McCrea, W.H.

    1983-01-01

    In this paper, it is suggested that unseen matter in a galactic envelope or in a group of galaxies may consist of substellar bodies originating as the first permanent 'stars' in the formation of a very massive galaxy according to a model for galaxy-formation on the basis of simple big-bang cosmology. (Auth.)

  5. Handbook on data envelopment analysis

    CERN Document Server

    Cooper, William W; Zhu, Joe

    2011-01-01

    Focusing on extensively used Data Envelopment Analysis topics, this volume aims to both describe the state of the field and extend the frontier of DEA research. New chapters include DEA models for DMUs, network DEA, models for supply chain operations and applications, and new developments.

  6. The effect of font size and type on reading performance with Arabic words in normally sighted and simulated cataract subjects.

    Science.gov (United States)

    Alotaibi, Abdullah Z

    2007-05-01

    Previous investigations have shown that reading is the most common functional problem reported by patients at a low vision practice. While there have been studies investigating effect of fonts in normal and low vision patients in English, no study has been carried out in Arabic. Additionally, there has been no investigation into the use of optimum print sizes or fonts that should be used in Arabic books and leaflets for low vision patients. Arabic sentences were read by 100 normally sighted volunteers with and without simulated cataract. Subjects read two font types (Times New Roman and Courier) in three different sizes (N8, N10 and N12). The subjects were asked to read the sentences aloud. The reading speed was calculated as number of words read divided by the time taken, while reading rate was calculated as the number of words read correctly divided by the time taken. There was an improvement in reading performance of normally sighted and simulated visually impaired subjects when the print size increased. There was no significant difference in reading performance between the two types of font used at small print size, however the reading rate improved as print size increased with Times New Roman. The results suggest that the use of N12 print in Times New Roman enhanced reading performance in normally sighted and simulated cataract subjects.

  7. Data Envelopment Analysis (DEA) Model in Operation Management

    Science.gov (United States)

    Malik, Meilisa; Efendi, Syahril; Zarlis, Muhammad

    2018-01-01

    Quality management is an effective system in operation management to develops, maintains, and improves quality from groups of companies that allow marketing, production, and service at the most economycal level as well as ensuring customer satisfication. Many companies are practicing quality management to improve their bussiness performance. One of performance measurement is through measurement of efficiency. One of the tools can be used to assess efficiency of companies performance is Data Envelopment Analysis (DEA). The aim of this paper is using Data Envelopment Analysis (DEA) model to assess efficiency of quality management. In this paper will be explained CCR, BCC, and SBM models to assess efficiency of quality management.

  8. Condensins Exert Force on Chromatin-Nuclear Envelope Tethers to Mediate Nucleoplasmic Reticulum Formation in Drosophila melanogaster

    Science.gov (United States)

    Bozler, Julianna; Nguyen, Huy Q.; Rogers, Gregory C.; Bosco, Giovanni

    2014-01-01

    Although the nuclear envelope is known primarily for its role as a boundary between the nucleus and cytoplasm in eukaryotes, it plays a vital and dynamic role in many cellular processes. Studies of nuclear structure have revealed tissue-specific changes in nuclear envelope architecture, suggesting that its three-dimensional structure contributes to its functionality. Despite the importance of the nuclear envelope, the factors that regulate and maintain nuclear envelope shape remain largely unexplored. The nuclear envelope makes extensive and dynamic interactions with the underlying chromatin. Given this inexorable link between chromatin and the nuclear envelope, it is possible that local and global chromatin organization reciprocally impact nuclear envelope form and function. In this study, we use Drosophila salivary glands to show that the three-dimensional structure of the nuclear envelope can be altered with condensin II-mediated chromatin condensation. Both naturally occurring and engineered chromatin-envelope interactions are sufficient to allow chromatin compaction forces to drive distortions of the nuclear envelope. Weakening of the nuclear lamina further enhanced envelope remodeling, suggesting that envelope structure is capable of counterbalancing chromatin compaction forces. Our experiments reveal that the nucleoplasmic reticulum is born of the nuclear envelope and remains dynamic in that they can be reabsorbed into the nuclear envelope. We propose a model where inner nuclear envelope-chromatin tethers allow interphase chromosome movements to change nuclear envelope morphology. Therefore, interphase chromatin compaction may be a normal mechanism that reorganizes nuclear architecture, while under pathological conditions, such as laminopathies, compaction forces may contribute to defects in nuclear morphology. PMID:25552604

  9. Condensins exert force on chromatin-nuclear envelope tethers to mediate nucleoplasmic reticulum formation in Drosophila melanogaster.

    Science.gov (United States)

    Bozler, Julianna; Nguyen, Huy Q; Rogers, Gregory C; Bosco, Giovanni

    2014-12-30

    Although the nuclear envelope is known primarily for its role as a boundary between the nucleus and cytoplasm in eukaryotes, it plays a vital and dynamic role in many cellular processes. Studies of nuclear structure have revealed tissue-specific changes in nuclear envelope architecture, suggesting that its three-dimensional structure contributes to its functionality. Despite the importance of the nuclear envelope, the factors that regulate and maintain nuclear envelope shape remain largely unexplored. The nuclear envelope makes extensive and dynamic interactions with the underlying chromatin. Given this inexorable link between chromatin and the nuclear envelope, it is possible that local and global chromatin organization reciprocally impact nuclear envelope form and function. In this study, we use Drosophila salivary glands to show that the three-dimensional structure of the nuclear envelope can be altered with condensin II-mediated chromatin condensation. Both naturally occurring and engineered chromatin-envelope interactions are sufficient to allow chromatin compaction forces to drive distortions of the nuclear envelope. Weakening of the nuclear lamina further enhanced envelope remodeling, suggesting that envelope structure is capable of counterbalancing chromatin compaction forces. Our experiments reveal that the nucleoplasmic reticulum is born of the nuclear envelope and remains dynamic in that they can be reabsorbed into the nuclear envelope. We propose a model where inner nuclear envelope-chromatin tethers allow interphase chromosome movements to change nuclear envelope morphology. Therefore, interphase chromatin compaction may be a normal mechanism that reorganizes nuclear architecture, while under pathological conditions, such as laminopathies, compaction forces may contribute to defects in nuclear morphology. Copyright © 2015 Bozler et al.

  10. A recursive field-normalized bibliometric performance indicator: an application to the field of library and information science.

    Science.gov (United States)

    Waltman, Ludo; Yan, Erjia; van Eck, Nees Jan

    2011-10-01

    Two commonly used ideas in the development of citation-based research performance indicators are the idea of normalizing citation counts based on a field classification scheme and the idea of recursive citation weighing (like in PageRank-inspired indicators). We combine these two ideas in a single indicator, referred to as the recursive mean normalized citation score indicator, and we study the validity of this indicator. Our empirical analysis shows that the proposed indicator is highly sensitive to the field classification scheme that is used. The indicator also has a strong tendency to reinforce biases caused by the classification scheme. Based on these observations, we advise against the use of indicators in which the idea of normalization based on a field classification scheme and the idea of recursive citation weighing are combined.

  11. Thermal Responsive Envelope

    DEFF Research Database (Denmark)

    Foged, Isak Worre; Pasold, Anke

    2015-01-01

    The paper presents an architectural computational method and model, which, through additive and subtractive processes, create composite elements with bending behaviour based on thermal variations in the surrounding climatic environment. The present effort is focused on the manipulation of assembly...... alterations, their respective durability and copper’s architectural (visual and transformative) aesthetic qualities. Through the use of an evolutionary solver, the composite structure of the elements are organised to find the bending behaviour specified by and for the thermal environments. The entire model...... in which the behavioural composites are organised in modules and how they act and perform. Furthermore, a large full-scale prototype is made as a demonstrator and experimental setup for post-construct analysis and evaluation of the design research. The work finds that the presented method and model can...

  12. Design practice and operational experience of highly irradiated, high-performance normal magnets

    International Nuclear Information System (INIS)

    Schultz, J.H.

    1982-09-01

    The limitations of high performance magnets are discussed in terms of mechanical, temperature, and electrical limits. The limitations of magnets that are highly irradiated by neutrons, gamma radiation, or x radiation are discussed

  13. Hysteretic evaluation of seismic performance of normal and fiber reinforced concrete shear walls

    International Nuclear Information System (INIS)

    Choun, Young Sun; Hahm, Dae Gi

    2012-01-01

    The use of fibers in concrete or cement composites can enhance the performance of structural elements. Fibers have been used for a cement mixture to increase the toughness and tensile strength, and to improve the cracking and deformation characteristics. The addition of fibers into concrete can improve the ductility and increase the seismic resistance of concrete structures. The application of fibers to earthquake-resistant concrete structures has a major research topic. A recent study shows that an excellent seismic performance can be obtained in shear critical members constructed with high performance fiber reinforced cement composites. To increase the seismic performance of safety related concrete structures in nuclear power plants, fibers can be used. This study investigated the effect of fibers on the hysteretic behavior of a reinforced concrete (RC) shear wall by cyclic tests

  14. Hysteretic evaluation of seismic performance of normal and fiber reinforced concrete shear walls

    Energy Technology Data Exchange (ETDEWEB)

    Choun, Young Sun; Hahm, Dae Gi [KAERI, Daejeon (Korea, Republic of)

    2012-10-15

    The use of fibers in concrete or cement composites can enhance the performance of structural elements. Fibers have been used for a cement mixture to increase the toughness and tensile strength, and to improve the cracking and deformation characteristics. The addition of fibers into concrete can improve the ductility and increase the seismic resistance of concrete structures. The application of fibers to earthquake-resistant concrete structures has a major research topic. A recent study shows that an excellent seismic performance can be obtained in shear critical members constructed with high performance fiber reinforced cement composites. To increase the seismic performance of safety related concrete structures in nuclear power plants, fibers can be used. This study investigated the effect of fibers on the hysteretic behavior of a reinforced concrete (RC) shear wall by cyclic tests.

  15. Combined centroid-envelope dynamics of intense, magnetically focused charged beams surrounded by conducting walls

    International Nuclear Information System (INIS)

    Fiuza, K.; Rizzato, F.B.; Pakter, R.

    2006-01-01

    In this paper we analyze the combined envelope-centroid dynamics of magnetically focused high-intensity charged beams surrounded by conducting walls. Similar to the case where conducting walls are absent, it is shown that the envelope and centroid dynamics decouple from each other. Mismatched envelopes still decay into equilibrium with simultaneous emittance growth, but the centroid keeps oscillating with no appreciable energy loss. Some estimates are performed to analytically obtain characteristics of halo formation seen in the full simulations

  16. Predicting memory performance in normal ageing using different measures of hippocampal size

    International Nuclear Information System (INIS)

    Lye, T.C.; Creasey, H.; Kril, J.J.; Grayson, D.A.; Piguet, O.; Bennett, H.P.; Ridley, L.J.; Broe, G.A.

    2006-01-01

    A number of different methods have been employed to correct hippocampal volumes for individual variation in head size. Researchers have previously used qualitative visual inspection to gauge hippocampal atrophy. The purpose of this study was to determine the best measure(s) of hippocampal size for predicting memory functioning in 102 community-dwelling individuals over 80 years of age. Hippocampal size was estimated using magnetic resonance imaging (MRI) volumetry and qualitative visual assessment. Right and left hippocampal volumes were adjusted by three different estimates of head size: total intracranial volume (TICV), whole-brain volume including ventricles (WB+V) and a more refined measure of whole-brain volume with ventricles extracted (WB). We compared the relative efficacy of these three volumetric adjustment methods and visual ratings of hippocampal size in predicting memory performance using linear regression. All four measures of hippocampal size were significant predictors of memory performance. TICV-adjusted volumes performed most poorly in accounting for variance in memory scores. Hippocampal volumes adjusted by either measure of whole-brain volume performed equally well, although qualitative visual ratings of the hippocampus were at least as effective as the volumetric measures in predicting memory performance in community-dwelling individuals in the ninth or tenth decade of life. (orig.)

  17. Performance Envelopes and Optimal Appropriateness Measurement.

    Science.gov (United States)

    1984-12-01

    20370 Dr. Hans Crombag University of Leyden Mr. Raymond E. Christal Education Research Center AFHRL/MOE Boerhaavelaan 2 Brooks AFB, TX 78235 2334 EN... Leyden The NETHERLANDS Dr. Norman Cliff Department of Psychology CTB/McGraw-Hill Library Univ. of So. California 2500 Garden Road University Park...Psychology Dr William Montague University of Western Australia NPRDC Code 13 Nedlands W.A. 6009 San Diego, CA 92152 AUSTRALIA Ms. Kathleen Moreno Dr

  18. Constant envelope OFDM scheme for 6PolSK-QPSK

    Science.gov (United States)

    Li, Yupeng; Ding, Ding

    2018-03-01

    A constant envelope OFDM scheme with phase modulator (PM-CE-OFDM) for 6PolSK-QPSK modulation was demonstrated. Performance under large fiber launch power is measured to check its advantages in counteracting fiber nonlinear impairments. In our simulation, PM-CE-OFDM, RF-assisted constant envelope OFDM (RF-CE-OFDM) and conventional OFDM (Con-OFDM) are transmitted through 80 km standard single mode fiber (SSMF) single channel and WDM system. Simulation results confirm that PM-CE-OFDM has best performance in resisting fiber nonlinearity. In addition, benefiting from the simple system structure, the complexity and cost of PM-CE-OFDM system could be reduced effectively.

  19. Different effects of adding white noise on cognitive performance of sub-, normal and super-attentive school children.

    Directory of Open Access Journals (Sweden)

    Suzannah K Helps

    Full Text Available Noise often has detrimental effects on performance. However, because of the phenomenon of stochastic resonance (SR, auditory white noise (WN can alter the "signal to noise" ratio and improve performance. The Moderate Brain Arousal (MBA model postulates different levels of internal "neural noise" in individuals with different attentional capacities. This in turn determines the particular WN level most beneficial in each individual case-with one level of WN facilitating poor attenders but hindering super-attentive children. The objective of the present study is to find out if added WN affects cognitive performance differently in children that differ in attention ability.Participants were teacher-rated super- (N = 25; normal- (N = 29 and sub-attentive (N = 36 children (aged 8 to 10 years. Two non-executive function (EF tasks (a verbal episodic recall task and a delayed verbal recognition task and two EF tasks (a visuo-spatial working memory test and a Go-NoGo task were performed under three WN levels. The non-WN condition was only used to control for potential differences in background noise in the group testing situations.There were different effects of WN on performance in the three groups-adding moderate WN worsened the performance of super-attentive children for both task types and improved EF performance in sub-attentive children. The normal-attentive children's performance was unaffected by WN exposure. The shift from moderate to high levels of WN had little further effect on performance in any group.The predicted differential effect of WN on performance was confirmed. However, the failure to find evidence for an inverted U function challenges current theories. Alternative explanations are discussed. We propose that WN therapy should be further investigated as a possible non-pharmacological treatment for inattention.

  20. Different effects of adding white noise on cognitive performance of sub-, normal and super-attentive school children.

    Science.gov (United States)

    Helps, Suzannah K; Bamford, Susan; Sonuga-Barke, Edmund J S; Söderlund, Göran B W

    2014-01-01

    Noise often has detrimental effects on performance. However, because of the phenomenon of stochastic resonance (SR), auditory white noise (WN) can alter the "signal to noise" ratio and improve performance. The Moderate Brain Arousal (MBA) model postulates different levels of internal "neural noise" in individuals with different attentional capacities. This in turn determines the particular WN level most beneficial in each individual case-with one level of WN facilitating poor attenders but hindering super-attentive children. The objective of the present study is to find out if added WN affects cognitive performance differently in children that differ in attention ability. Participants were teacher-rated super- (N = 25); normal- (N = 29) and sub-attentive (N = 36) children (aged 8 to 10 years). Two non-executive function (EF) tasks (a verbal episodic recall task and a delayed verbal recognition task) and two EF tasks (a visuo-spatial working memory test and a Go-NoGo task) were performed under three WN levels. The non-WN condition was only used to control for potential differences in background noise in the group testing situations. There were different effects of WN on performance in the three groups-adding moderate WN worsened the performance of super-attentive children for both task types and improved EF performance in sub-attentive children. The normal-attentive children's performance was unaffected by WN exposure. The shift from moderate to high levels of WN had little further effect on performance in any group. The predicted differential effect of WN on performance was confirmed. However, the failure to find evidence for an inverted U function challenges current theories. Alternative explanations are discussed. We propose that WN therapy should be further investigated as a possible non-pharmacological treatment for inattention.

  1. Transparent ceramic lamp envelope materials

    Energy Technology Data Exchange (ETDEWEB)

    Wei, G C [OSRAM SYLVANIA, 71 Cherry Hill Drive, Beverly, MA 01915 (United States)

    2005-09-07

    Transparent ceramic materials with optical qualities comparable to single crystals of similar compositions have been developed in recent years, as a result of the improved understanding of powder-processing-fabrication- sintering-property inter-relationships. These high-temperature materials with a range of thermal and mechanical properties are candidate envelopes for focused-beam, short-arc lamps containing various fills operating at temperatures higher than quartz. This paper reviews the composition, structure and properties of transparent ceramic lamp envelope materials including sapphire, small-grained polycrystalline alumina, aluminium oxynitride, yttrium aluminate garnet, magnesium aluminate spinel and yttria-lanthana. A satisfactory thermal shock resistance is required for the ceramic tube to withstand the rapid heating and cooling cycles encountered in lamps. Thermophysical properties, along with the geometry, size and thickness of a transparent ceramic tube, are important parameters in the assessment of its resistance to fracture arising from thermal stresses in lamps during service. The corrosive nature of lamp-fill liquid and vapour at high temperatures requires that all lamp components be carefully chosen to meet the target life. The wide range of new transparent ceramics represents flexibility in pushing the limit of envelope materials for improved beamer lamps.

  2. Normal weight children have higher cognitive performance – Independent of physical activity, sleep, and diet

    DEFF Research Database (Denmark)

    Hjorth, Mads F.; Sørensen, Louise B.; Andersen, Rikke

    2016-01-01

    % of expected learning within one school year (P breakfast consumption, fewer sleep problems, higher CRF, less total physical activity, more sedentary time, and less light physical activity were associated with higher cognitive performance independently of each other in at least one of the three...

  3. INTRAOPERATIVE MOTIVE FOR PERFORMING A LAPAROSCOPIC APPENDECTOMY ON A POSTOPERATIVE HISTOLOGICAL PROVEN NORMAL APPENDIX

    NARCIS (Netherlands)

    Slotboom, T.; Hamminga, J. T. H.; Hofker, H. S.; Heineman, E.; Haveman, J. W.

    2014-01-01

    Background: Diagnostic laparoscopy is the ultimate tool to evaluate the appendix. However, the intraoperative evaluation of the appendix is difficult, as the negative appendectomy rate remains 12%-18%. The aim of this study is to analyze the intraoperative motive for performing a laparoscopic

  4. Differences in kata performance time and distance from a marker for experienced Shotokan karateka under normal sighted and blindfolded conditions.

    Science.gov (United States)

    Layton, Clive; Avenell, Leon

    2002-08-01

    10 experienced Shotokan karateka were tested on performance time and distance from a marker on the five Heian kata under normal sighted and blind-folded conditions. Whilst each kata's line of movement is different, it is the intention to start and finish at the same location. Analysis showed that despite an average of 16.8 yr. of training, whilst timing was not significantly affected on four of the kata by subjects being deprived of the visual sense, the group's mean change in distance from an original marker was significant for performances on three of the kata.

  5. Cognitive function predicts listening effort performance during complex tasks in normally aging adults

    Directory of Open Access Journals (Sweden)

    Jennine Harvey

    2017-01-01

    Full Text Available Purpose: This study examines whether cognitive function, as measured by the subtests of the Woodcock–Johnson III (WCJ-III assessment, predicts listening-effort performance during dual tasks across the adults of varying ages. Materials and Methods: Participants were divided into two groups. Group 1 consisted of 14 listeners (number of females = 11 who were 41–61 years old [mean = 53.18; standard deviation (SD = 5.97]. Group 2 consisted of 15 listeners (number of females = 9 who were 63–81 years old (mean = 72.07; SD = 5.11. Participants were administered the WCJ-III Memory for Words, Auditory Working Memory, Visual Matching, and Decision Speed subtests. All participants were tested in each of the following three dual-task experimental conditions, which were varying in complexity: (1 auditory word recognition + visual processing, (2 auditory working memory (word + visual processing, and (3 auditory working memory (sentence + visual processing in noise. Results: A repeated measures analysis of variance revealed that task complexity significantly affected the performance measures of auditory accuracy, visual accuracy, and processing speed. Linear regression revealed that the cognitive subtests of the WCJ-III test significantly predicted performance across dependent variable measures. Conclusion: Listening effort is significantly affected by task complexity, regardless of age. Performance on the WCJ-III test may predict listening effort in adults and may assist speech-language pathologist (SLPs to understand challenges faced by participants when subjected to noise.

  6. Impact of changed fuel performances on safety barrier effectiveness at normal operation of NPP with WWER

    International Nuclear Information System (INIS)

    Zhurbenko, A. V.; Semchenkov, Y. M.; Slavyagin, P.D.

    2007-01-01

    The paper presents the analysis of adopted safety barriers against propagation of fission product released from WWER core of active power plants. Relationship between system and equipment performances and safety barriers is demonstrated. The fundamental principles of methodological approach to the operational limit determination based on the assessment of iodine-131 specific activity in the primary circuit are discussed. Problems of substantiating the operational limit for primary coolant activity are analyzed for conditions of growing burnup (Authors)

  7. Performances on a cognitive theory of mind task: specific decline or general cognitive deficits? Evidence from normal aging.

    Science.gov (United States)

    Fliss, Rafika; Lemerre, Marion; Mollard, Audrey

    2016-06-01

    Compromised theory of mind (ToM) can be explained either by a failure to implement specific representational capacities (mental state representations) or by more general executive selection demands. In older adult populations, evidence supporting affected executive functioning and cognitive ToM in normal aging are reported. However, links between these two functions remain unclear. In the present paper, we address these shortcomings by using a specific task of ToM and classical executive tasks. We studied, using an original cognitive ToM task, the effect of age on ToM performances, in link with the progressive executive decline. 96 elderly participants were recruited. They were asked to perform a cognitive ToM task, and 5 executive tests (Stroop test and Hayling Sentence Completion Test to appreciate inhibitory process, Trail Making Test and Verbal Fluency for shifting assessment and backward span dedicated to estimate working memory capacity). The results show changes in cognitive ToM performance according to executive demands. Correlational studies indicate a significant relationship between ToM performance and the selected executive measures. Regression analyzes demonstrates that level of vocabulary and age as the best predictors of ToM performance. The results are consistent with the hypothesis that ToM deficits are related to age-related domain-general decline rather than as to a breakdown in specialized representational system. The implications of these findings for the nature of social cognition tests in normal aging are also discussed.

  8. Cerebral Blood Flow and Amyloid-β Interact to Affect Memory Performance in Cognitively Normal Older Adults

    Directory of Open Access Journals (Sweden)

    Katherine J. Bangen

    2017-06-01

    Full Text Available Cerebral blood flow (CBF alterations and amyloid-β (Aβ accumulation have been independently linked to cognitive deficits in older adults at risk for dementia. Less is known about how CBF and Aβ may interact to affect cognition in cognitively normal older adults. Therefore, we examined potential statistical interactions between CBF and Aβ status in regions typically affected in Alzheimer’s disease (AD within a sample of older adults from the Alzheimer’s Disease Neuroimaging Initiative (ADNI study. Sixty-two cognitively normal participants (mean age = 72 years underwent neuroimaging and memory testing. Arterial spin labeling magnetic resonance imaging was used to quantify CBF and florbetapir PET amyloid imaging was used to measure Aβ deposition. Aβ status (i.e., positivity versus negativity was determined based on established cutoffs (Landau et al., 2013. The Rey Auditory Verbal Learning Test was used to assess memory. Linear regression models adjusted for age, education, and sex, demonstrated significant interactions between CBF and Aβ status on memory performance. Among Aβ positive older adults, there were significant negative associations between higher CBF in hippocampus, posterior cingulate, and precuneus and poorer memory performance. In contrast, among Aβ negative older adults, there were no significant associations between CBF and cognition. Our findings extend previous CBF studies of dementia risk by reporting interactions between Aβ status and CBF on memory performance in a sample of well-characterized, cognitively normal older adults. Results suggest that differential CBF-cognition associations can be identified in healthy, asymptomatic Aβ positive older adults relative to Aβ negative individuals. Associations between higherCBF and poorer memory among Aβ positive older adults may reflect a cellular and/or vascular compensatory response to pathologic processes whereby higher CBF is needed to maintain normal memory

  9. A new insight into opaque envelopes in a passive solar house: Properties and roles

    International Nuclear Information System (INIS)

    Long, Linshuang; Ye, Hong; Liu, Minghou

    2016-01-01

    Highlights: • A new insight into the opaque envelopes of a passive solar house was gained. • Five parts of envelopes, i.e., roof, south/east/west/north walls, were discussed. • Each part of envelopes were analyzed separately rather than treated as a whole. • Ideal properties of materials for each envelope are diverse from one another. • Differences are related to the envelopes’ leading roles as a heater or a cooler. - Abstract: Passive solar houses are effective solutions for minimizing the operating energy of buildings. The building envelopes of passive solar houses exert a significant influence on the degree of indoor thermal comfort. The focus of this study was the construction of high-performance opaque envelopes, i.e., the roof and walls, for a passive solar house, and a new conception of the envelopes from the perspective of the relation between the properties and roles was provided. The discussion was conducted based on a comprehensive range of envelope materials that were distinguished by the thermal conductivity and volumetric heat capacity. For the first time, each part of the envelopes was analyzed separately rather than considered as an entire envelope. By analyzing each envelope individually, the optimum properties of each envelope were found to be distinct from each other. The distinctions are determined by the dominant role of each envelope, which is associated with the location and absorbed solar irradiation. For summer or hot climate applications, when the dominant role is a cooler, the envelope, e.g., the south wall, should consist of materials with high thermal conductivity and large heat capacity; if a heater is the dominant role, the envelope, e.g., the roof, should consist of materials with low thermal conductivity. For winter or cold climate applications, the envelopes with a leading role of a heater or a cooler require materials with high or low thermal conductivity, respectively. Under the guidance of the results, a discussion

  10. Effects of Age and Working Memory Capacity on Speech Recognition Performance in Noise Among Listeners With Normal Hearing.

    Science.gov (United States)

    Gordon-Salant, Sandra; Cole, Stacey Samuels

    2016-01-01

    This study aimed to determine if younger and older listeners with normal hearing who differ on working memory span perform differently on speech recognition tests in noise. Older adults typically exhibit poorer speech recognition scores in noise than younger adults, which is attributed primarily to poorer hearing sensitivity and more limited working memory capacity in older than younger adults. Previous studies typically tested older listeners with poorer hearing sensitivity and shorter working memory spans than younger listeners, making it difficult to discern the importance of working memory capacity on speech recognition. This investigation controlled for hearing sensitivity and compared speech recognition performance in noise by younger and older listeners who were subdivided into high and low working memory groups. Performance patterns were compared for different speech materials to assess whether or not the effect of working memory capacity varies with the demands of the specific speech test. The authors hypothesized that (1) normal-hearing listeners with low working memory span would exhibit poorer speech recognition performance in noise than those with high working memory span; (2) older listeners with normal hearing would show poorer speech recognition scores than younger listeners with normal hearing, when the two age groups were matched for working memory span; and (3) an interaction between age and working memory would be observed for speech materials that provide contextual cues. Twenty-eight older (61 to 75 years) and 25 younger (18 to 25 years) normal-hearing listeners were assigned to groups based on age and working memory status. Northwestern University Auditory Test No. 6 words and Institute of Electrical and Electronics Engineers sentences were presented in noise using an adaptive procedure to measure the signal-to-noise ratio corresponding to 50% correct performance. Cognitive ability was evaluated with two tests of working memory (Listening

  11. Effect of different types of music on exercise performance in normal individuals.

    Science.gov (United States)

    Thakur, Anuprita M; Yardi, Sujata S

    2013-01-01

    While exercising, people seem to enjoy listening to music believing that it relaxes them or helps give the necessary rhythm for exercise. But is music really beneficial? In view of different people listening to different types of music, this study was intended to assess effect of different types of music on exercise performance. 30 healthy female college students in the age group of 18 to 25 years were made to walk on the treadmill 3 times at one week interval: without music (A), with slow music (B), with fast music (C). Duration of exercise and rate of perceived exertion were recorded at the end of each session. The results showed an increase in the duration of exercise in Group B and Group C as compared to Group A and the increase was more in Group C as compared to Group B. It was observed that level of RPE was the same at the end of every exercise session. The reason for increase in exercise duration with music could be because of various factors like dissociation, arousal, motivation, etc. It can be thus suggested that exercises can be performed for longer duration with music than without music and the effect is more with fast music than with slow music. Also with music, the same level of exertion is perceived though the walking duration is considerably increased.

  12. Reading performance of monofocal pseudophakic patients with and without glasses under normal and dim light conditions.

    Science.gov (United States)

    Radner, Wolfgang; Radner, Stephan; Raunig, Valerian; Diendorfer, Gabriela

    2014-03-01

    To evaluate reading performance of patients with monofocal intraocular lenses (IOLs) (Acrysof SN60WF) with or without reading glasses under bright and dim light conditions. Austrian Academy of Ophthalmology, Vienna, Austria. Evaluation of a diagnostic test or technology. In pseudophakic patients, the spherical refractive error was limited to between +0.50 diopter (D) and -0.75 D with astigmatism of 0.75 D (mean spherical equivalent: right eye, -0.08 ± 0.43 [SD]; left eye, -0.15 ± 0.35). Near addition was +2.75 D. Reading performance was assessed binocularly with or without reading glasses at an illumination of 100 candelas (cd)/m(2) and 4 cd/m(2) using the Radner Reading Charts. In the 25 patients evaluated, binocularly, the mean corrected distance visual acuity was -0.07 ± 0.06 logMAR and the mean uncorrected distance visual acuity was 0.01 ± 0.11 logMAR. The mean reading acuity with reading glasses was 0.02 ± 0.10 logRAD at 100 cd/m(2) and 0.12 ± 0.14 logRAD at 4 cd/m(2). Without reading glasses, it was 0.44 ± 0.13 logRAD and 0.56 ± 0.16 logRAD, respectively (P light conditions. Copyright © 2014 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  13. Diagnosing dementia and normal aging: clinical relevance of brain ratios and cognitive performance in a Brazilian sample

    Directory of Open Access Journals (Sweden)

    Chaves M.L.F.

    1999-01-01

    Full Text Available The main objective of the present study was to evaluate the diagnostic value (clinical application of brain measures and cognitive function. Alzheimer and multiinfarct patients (N = 30 and normal subjects over the age of 50 (N = 40 were submitted to a medical, neurological and cognitive investigation. The cognitive tests applied were Mini-Mental, word span, digit span, logical memory, spatial recognition span, Boston naming test, praxis, and calculation tests. The brain ratios calculated were the ventricle-brain, bifrontal, bicaudate, third ventricle, and suprasellar cistern measures. These data were obtained from a brain computer tomography scan, and the cutoff values from receiver operating characteristic curves. We analyzed the diagnostic parameters provided by these ratios and compared them to those obtained by cognitive evaluation. The sensitivity and specificity of cognitive tests were higher than brain measures, although dementia patients presented higher ratios, showing poorer cognitive performances than normal individuals. Normal controls over the age of 70 presented higher measures than younger groups, but similar cognitive performance. We found diffuse losses of tissue from the central nervous system related to distribution of cerebrospinal fluid in dementia patients. The likelihood of case identification by functional impairment was higher than when changes of the structure of the central nervous system were used. Cognitive evaluation still seems to be the best method to screen individuals from the community, especially for developing countries, where the cost of brain imaging precludes its use for screening and initial assessment of dementia.

  14. The comparison of balance performance among children with cochlear implantation, post-aural aid and normal children

    Directory of Open Access Journals (Sweden)

    Arezoo Ahmad pour

    2014-11-01

    Full Text Available Background: This cross-sectional study was carried out to compare balance performance between children with cochlear implants and post-aural aid and normal children. Methods: The present study was done on 67 severe to profound hearing impaired children. Of these, 21 children with an average age of 7 years and 4 months (±1.7 wore cochlear implant, 46 children with an average age of 7 years and 7 months (±1.7 wore post-aural aid and 60 children with an average 8 years and one month (±11 months were considered as a control group. All of the children were tested with the 9-stage balance subtest of Bruininks-Oseretsky Test of Motor Proficiency2 (BOT2. Results: The mean total BOT2 score of hearing impaired children was significantly lower than the normal group (P≤0.001. The mean total BOT2 score among children with cochlear implant, post-aural aids and normal group showed that cochlear implant group significantly performed weaker than the other two groups (P≤0.001. Conclusion: Hearing impaired children particularly children with cochlear implant are exposed to the risk of balance deficit. Hearing impaired children specially those who wear cochlear implants must be screened for vestibular hypofunction.

  15. Performance improvement of two-dimensional EUV spectroscopy based on high frame rate CCD and signal normalization method

    International Nuclear Information System (INIS)

    Zhang, H.M.; Morita, S.; Ohishi, T.; Goto, M.; Huang, X.L.

    2014-01-01

    In the Large Helical Device (LHD), the performance of two-dimensional (2-D) extreme ultraviolet (EUV) spectroscopy with wavelength range of 30-650A has been improved by installing a high frame rate CCD and applying a signal intensity normalization method. With upgraded 2-D space-resolved EUV spectrometer, measurement of 2-D impurity emission profiles with high horizontal resolution is possible in high-density NBI discharges. The variation in intensities of EUV emission among a few discharges is significantly reduced by normalizing the signal to the spectral intensity from EUV_—Long spectrometer which works as an impurity monitor with high-time resolution. As a result, high resolution 2-D intensity distribution has been obtained from CIV (384.176A), CV(2x40.27A), CVI(2x33.73A) and HeII(303.78A). (author)

  16. [An improved algorithm for electrohysterogram envelope extraction].

    Science.gov (United States)

    Lu, Yaosheng; Pan, Jie; Chen, Zhaoxia; Chen, Zhaoxia

    2017-02-01

    Extraction uterine contraction signal from abdominal uterine electromyogram(EMG) signal is considered as the most promising method to replace the traditional tocodynamometer(TOCO) for detecting uterine contractions activity. The traditional root mean square(RMS) algorithm has only some limited values in canceling the impulsive noise. In our study, an improved algorithm for uterine EMG envelope extraction was proposed to overcome the problem. Firstly, in our experiment, zero-crossing detection method was used to separate the burst of uterine electrical activity from the raw uterine EMG signal. After processing the separated signals by employing two filtering windows which have different width, we used the traditional RMS algorithm to extract uterus EMG envelope. To assess the performance of the algorithm, the improved algorithm was compared with two existing intensity of uterine electromyogram(IEMG) extraction algorithms. The results showed that the improved algorithm was better than the traditional ones in eliminating impulsive noise present in the uterine EMG signal. The measurement sensitivity and positive predictive value(PPV) of the improved algorithm were 0.952 and 0.922, respectively, which were not only significantly higher than the corresponding values(0.859 and 0.847) of the first comparison algorithm, but also higher than the values(0.928 and 0.877) of the second comparison algorithm. Thus the new method is reliable and effective.

  17. Cortical processing of dynamic sound envelope transitions.

    Science.gov (United States)

    Zhou, Yi; Wang, Xiaoqin

    2010-12-08

    Slow envelope fluctuations in the range of 2-20 Hz provide important segmental cues for processing communication sounds. For a successful segmentation, a neural processor must capture envelope features associated with the rise and fall of signal energy, a process that is often challenged by the interference of background noise. This study investigated the neural representations of slowly varying envelopes in quiet and in background noise in the primary auditory cortex (A1) of awake marmoset monkeys. We characterized envelope features based on the local average and rate of change of sound level in envelope waveforms and identified envelope features to which neurons were selective by reverse correlation. Our results showed that envelope feature selectivity of A1 neurons was correlated with the degree of nonmonotonicity in their static rate-level functions. Nonmonotonic neurons exhibited greater feature selectivity than monotonic neurons in quiet and in background noise. The diverse envelope feature selectivity decreased spike-timing correlation among A1 neurons in response to the same envelope waveforms. As a result, the variability, but not the average, of the ensemble responses of A1 neurons represented more faithfully the dynamic transitions in low-frequency sound envelopes both in quiet and in background noise.

  18. Efficiency Enhancement of an Envelope Tracking Power Amplifier Combining Supply Shaping and Dynamic Biasing

    DEFF Research Database (Denmark)

    Tafuri, Felice Francesco; Sira, Daniel; Jensen, Ole Kiel

    2013-01-01

    This paper presents a new method to improve the performance of envelope tracking (ET) power amplifiers (PAs). The method consists of combining the supply modulation that characterizes the envelope tracking architecture with supply shaping and dynamic biasing. The inclusion of dynamic biasing allo...

  19. Incipient failure detection of space shuttle main engine turbopump bearings using vibration envelope detection

    Science.gov (United States)

    Hopson, Charles B.

    1987-01-01

    The results of an analysis performed on seven successive Space Shuttle Main Engine (SSME) static test firings, utilizing envelope detection of external accelerometer data are discussed. The results clearly show the great potential for using envelope detection techniques in SSME incipient failure detection.

  20. Methods and data for HTGR fuel performance and radionuclide release modeling during normal operation and accidents for safety analysis

    International Nuclear Information System (INIS)

    Verfondern, K.; Martin, R.C.; Moormann, R.

    1993-01-01

    The previous status report released in 1987 on reference data and calculation models for fission product transport in High-Temperature, Gas-Cooled Reactor (HTGR) safety analyses has been updated to reflect the current state of knowledge in the German HTGR program. The content of the status report has been expanded to include information from other national programs in HTGRs to provide comparative information on methods of analysis and the underlying database for fuel performance and fission product transport. The release and transport of fission products during normal operating conditions and during the accident scenarios of core heatup, water and air ingress, and depressurization are discussed. (orig.) [de

  1. Torsin Mediates Primary Envelopment of Large Ribonucleoprotein Granules at the Nuclear Envelope

    Directory of Open Access Journals (Sweden)

    Vahbiz Jokhi

    2013-04-01

    Full Text Available A previously unrecognized mechanism through which large ribonucleoprotein (megaRNP granules exit the nucleus is by budding through the nuclear envelope (NE. This mechanism is akin to the nuclear egress of herpes-type viruses and is essential for proper synapse development. However, the molecular machinery required to remodel the NE during this process is unknown. Here, we identify Torsin, an AAA-ATPase that in humans is linked to dystonia, as a major mediator of primary megaRNP envelopment during NE budding. In torsin mutants, megaRNPs accumulate within the perinuclear space, and the messenger RNAs contained within fail to reach synaptic sites, preventing normal synaptic protein synthesis and thus proper synaptic bouton development. These studies begin to establish the cellular machinery underlying the exit of megaRNPs via budding, offer an explanation for the “nuclear blebbing” phenotype found in dystonia models, and provide an important link between Torsin and the synaptic phenotypes observed in dystonia.

  2. Evolution of envelope solitons of ionization waves

    International Nuclear Information System (INIS)

    Ohe, K.; Hashimoto, M.

    1985-01-01

    The time evolution of a particle-like envelope soliton of ionization waves in plasma was investigated theoretically. The hydrodynamic equations of one spatial dimension were solved and the nonlinear dispersion relation was derived. For the amplitude of the wave the nonlinear Schroedinger equation was derived. Its soliton solution was interpreted as the envelope soliton which was experimentally found. The damping rate of the envelope soliton was estimated. (D.Gy.)

  3. High Performance Electrical Modeling and Simulation Software Normal Environment Verification and Validation Plan, Version 1.0; TOPICAL

    International Nuclear Information System (INIS)

    WIX, STEVEN D.; BOGDAN, CAROLYN W.; MARCHIONDO JR., JULIO P.; DEVENEY, MICHAEL F.; NUNEZ, ALBERT V.

    2002-01-01

    The requirements in modeling and simulation are driven by two fundamental changes in the nuclear weapons landscape: (1) The Comprehensive Test Ban Treaty and (2) The Stockpile Life Extension Program which extends weapon lifetimes well beyond their originally anticipated field lifetimes. The move from confidence based on nuclear testing to confidence based on predictive simulation forces a profound change in the performance asked of codes. The scope of this document is to improve the confidence in the computational results by demonstration and documentation of the predictive capability of electrical circuit codes and the underlying conceptual, mathematical and numerical models as applied to a specific stockpile driver. This document describes the High Performance Electrical Modeling and Simulation software normal environment Verification and Validation Plan

  4. Extending the application range of a fuel performance code from normal operating to design basis accident conditions

    International Nuclear Information System (INIS)

    Van Uffelen, P.; Gyori, C.; Schubert, A.; Laar, J. van de; Hozer, Z.; Spykman, G.

    2008-01-01

    Two types of fuel performance codes are generally being applied, corresponding to the normal operating conditions and the design basis accident conditions, respectively. In order to simplify the code management and the interface between the codes, and to take advantage of the hardware progress it is favourable to generate a code that can cope with both conditions. In the first part of the present paper, we discuss the needs for creating such a code. The second part of the paper describes an example of model developments carried out by various members of the TRANSURANUS user group for coping with a loss of coolant accident (LOCA). In the third part, the validation of the extended fuel performance code is presented for LOCA conditions, whereas the last section summarises the present status and indicates needs for further developments to enable the code to deal with reactivity initiated accident (RIA) events

  5. Association of Plasma Neurofilament Light Chain with Neocortical Amyloid-β Load and Cognitive Performance in Cognitively Normal Elderly Participants.

    Science.gov (United States)

    Chatterjee, Pratishtha; Goozee, Kathryn; Sohrabi, Hamid R; Shen, Kaikai; Shah, Tejal; Asih, Prita R; Dave, Preeti; ManYan, Candice; Taddei, Kevin; Chung, Roger; Zetterberg, Henrik; Blennow, Kaj; Martins, Ralph N

    2018-01-01

    The disruption of neurofilament, an axonal cytoskeletal protein, in neurodegenerative conditions may result in neuronal damage and its release into the cerebrospinal fluid and blood. In Alzheimer's disease (AD), neurofilament light chain (NFL), a neurofilament subunit, is elevated in the cerebrospinal fluid and blood. Investigate the association of plasma NFL with preclinical-AD features, such as high neocortical amyloid-β load (NAL) and subjective memory complaints, and cognitive performance in cognitively normal older adults. Plasma NFL concentrations were measured employing the single molecule array platform in participants from the Kerr Anglican Retirement Village Initiative in Ageing Health cohort, aged 65- 90 years. Participants underwent a battery of neuropsychological testing to evaluate cognitive performance and were categorized as low NAL (NAL-, n = 65) and high NAL (NAL+, n = 35) assessed via PET, and further stratified into subjective memory complainers (SMC; nNAL- = 51, nNAL+ = 25) and non-SMC (nNAL- = 14, nNAL+ = 10) based on the Memory Assessment Clinic- Questionnaire. Plasma NFL inversely correlated with cognitive performance. No significant difference in NFL was observed between NAL+ and NAL- participants; however, within APOEɛ4 non-carriers, higher NAL was observed in individuals with NFL concentrations within quartiles 3 and 4 (versus quartile 1). Additionally, within the NAL+ participants, SMC had a trend of higher NFL compared to non-SMC. Plasma NFL is inversely associated with cognitive performance in elderly individuals. While plasma NFL may not reflect NAL in individuals with normal global cognition, the current observations indicate that onset of axonal injury, reflected by increased plasma NFL, within the preclinical phase of AD may contribute to the pathogenesis of AD.

  6. Multinodal control room envelope model used for habitability analysis

    International Nuclear Information System (INIS)

    Blumberg, W.M.; Gore, D.E.

    1995-01-01

    This work analyzes the habitability of the control room envelope (CRE) during an off-normal ventilation system condition. The most limiting design basis accident utilized for this analysis is the postulated loss-of-coolant accident. The off-normal condition assumes two rooms within the CRE are at pressures that are lower than adjoining rooms outside the CRE. This pressure differential allows unfiltered in-leakage to enter the CRE through the doors and penetrations in these rooms. This paper quantifies the maximum unfiltered in-leakage

  7. Mosaic HIV envelope immunogenic polypeptides

    Science.gov (United States)

    Korber, Bette T. M.; Gnanakaran, S.; Perkins, Simon; Sodroski, Joseph; Haynes, Barton

    2018-01-02

    Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are sets of the disclosed mosaic Env polypeptides, which include two or more (for example, three) of the polypeptides. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject infected with HIV or at risk of HIV infection. In some embodiments, the methods include inducing an immune response to HIV in a subject comprising administering to the subject at least one (such as two, three, or more) of the immunogenic polypeptides or at least one (such as two, three, or more) nucleic acids encoding at least one of the immunogenic polypeptides disclosed herein.

  8. Implementation of an Improved Safe Operating Envelope

    International Nuclear Information System (INIS)

    Prime, Robyn; McIntyre, Mark; Reeves, David

    2008-01-01

    This paper is a continuation of the paper presented at IYNC 2004 on 'The Definition of a Safe Operating Envelope'. The current paper concentrates on the implementation process of the Safe Operating Envelope employed at the Point Lepreau Generating Station. (authors)

  9. Physical properties of the red giant envelopes

    Energy Technology Data Exchange (ETDEWEB)

    Maciel, W J [Instituto de Astronomia e Geofisico da Universidade de Sao Paulo (Brazil)

    1978-12-01

    In this work, several model envelopes are calculated for cool giant stars with mass loss due to the action of stellar radiation pressure on molecules and grains. Molecular profiles as well as average values of some physical parameters of the envelopes are obtained.

  10. Physical properties of the red giant envelopes

    International Nuclear Information System (INIS)

    Maciel, W.J.

    1978-01-01

    In this work, several model envelopes are calculated for cool giant stars with mass loss due to the action of stellar radiation pressure on molecules and grains. Molecular profiles as well as average values of some physical parameters of the envelopes are obtained [pt

  11. Implementation of an Improved Safe Operating Envelope

    Energy Technology Data Exchange (ETDEWEB)

    Prime, Robyn; McIntyre, Mark [NB Power Nuclear, P.O. Box 600, Lepreau, NB (Canada); Reeves, David [Atlantic Nuclear Services Ltd., PO Box 1268 Fredericton, NB (Canada)

    2008-07-01

    This paper is a continuation of the paper presented at IYNC 2004 on 'The Definition of a Safe Operating Envelope'. The current paper concentrates on the implementation process of the Safe Operating Envelope employed at the Point Lepreau Generating Station. (authors)

  12. Effect of musical training on pitch discrimination performance in older normal-hearing and hearing-impaired listeners

    DEFF Research Database (Denmark)

    Bianchi, Federica; Dau, Torsten; Santurette, Sébastien

    2017-01-01

    -discrimination performance for NH listeners. It is unclear whether a comparable effect of musical training occurs for listeners whose sensory encoding of F0 is degraded. To address this question, F0 discrimination was investigated for three groups of listeners (14 young NH, 9 older NH and 10 HI listeners), each......Hearing-impaired (HI) listeners, as well as elderly listeners, typically have a reduced ability to discriminate the fundamental frequency (F0) of complex tones compared to young normal-hearing (NH) listeners. Several studies have shown that musical training, on the other hand, leads to improved F0...... including musicians and non-musicians, using complex tones that differed in harmonic content. Musical training significantly improved F0 discrimination for all groups of listeners, especially for complex tones containing low-numbered harmonics. In a second experiment, the sensitivity to temporal fine...

  13. Associations of Body Mass Index, Motor Performance, and Perceived Athletic Competence with Physical Activity in Normal Weight and Overweight Children.

    Science.gov (United States)

    Morrison, Kyle M; Cairney, John; Eisenmann, Joe; Pfeiffer, Karin; Gould, Dan

    2018-01-01

    Children who are overweight and obese display lower physical activity levels than normal weight peers. Measures of weight status, perceived motor competence, and motor skill performance have been identified as potential correlates explaining this discrepancy. 1881 children (955 males; 926 females; 9.9 years) were assessed as part of the Physical Health Activity Study Team project. The age, habitual physical activity participation (PAP), body mass index (BMI), socioeconomic status (SES), motor performance (MP), and perceived athletic competence (PAC) of each child included were assessed. Gender-specific linear regression analyses (main effects model) were conducted to identify the percent variance in PAP explained by the following variables: BMI, MP, and PAC. For males, 18.3% of the variance in PAP was explained by BMI, MP, and PAC. PAC explained 17% of the variance, while MP, BMI, and SES only accounted for 0.6%, 0.7%, and 0.5%, respectively. PAC explained 17.5% of PAP variance in females; MP explained 0.8%. BMI, SES, and chronological age were not significant correlates of PAP in girls. An established repertoire of motor skill performance has been seen as a vehicle to PAP in children; however, this study indicates that PAC should not be overlooked in intervention strategies to promote increased PAP.

  14. Associations of Body Mass Index, Motor Performance, and Perceived Athletic Competence with Physical Activity in Normal Weight and Overweight Children

    Directory of Open Access Journals (Sweden)

    Kyle M. Morrison

    2018-01-01

    Full Text Available Children who are overweight and obese display lower physical activity levels than normal weight peers. Measures of weight status, perceived motor competence, and motor skill performance have been identified as potential correlates explaining this discrepancy. 1881 children (955 males; 926 females; 9.9 years were assessed as part of the Physical Health Activity Study Team project. The age, habitual physical activity participation (PAP, body mass index (BMI, socioeconomic status (SES, motor performance (MP, and perceived athletic competence (PAC of each child included were assessed. Gender-specific linear regression analyses (main effects model were conducted to identify the percent variance in PAP explained by the following variables: BMI, MP, and PAC. For males, 18.3% of the variance in PAP was explained by BMI, MP, and PAC. PAC explained 17% of the variance, while MP, BMI, and SES only accounted for 0.6%, 0.7%, and 0.5%, respectively. PAC explained 17.5% of PAP variance in females; MP explained 0.8%. BMI, SES, and chronological age were not significant correlates of PAP in girls. An established repertoire of motor skill performance has been seen as a vehicle to PAP in children; however, this study indicates that PAC should not be overlooked in intervention strategies to promote increased PAP.

  15. Living an unstable everyday life while attempting to perform normality - the meaning of living as an alcohol-dependent woman.

    Science.gov (United States)

    Thurang, Anna; Bengtsson Tops, Anita

    2013-02-01

    To illuminate the meaning of living with alcohol dependency as a woman. The number of women suffering from alcohol dependency is increasing. Today there are shortcomings in knowledge about the lived experiences of being a woman with alcohol dependency; knowledge which might be of importance for meeting these women's specific needs of care. The study has a qualitative design. Fourteen women with alcohol dependency participated in open in-depth interviews. Data were analysed according to a phenomenological-hermeneutic method, and interpreted by help from gender and caring perspectives as well as results from previous research of alcohol dependency. In relation to the women's senses of well-being, four main gender formations were found; An unstable self involving continual and rapid swings between emotional and bodily reactions. Ambivalence - meaning ambiguous feelings towards themselves as human beings and how they lead their lives. Introspectiveness - involving reflections, pondering and being introverted. Attempts to perform normality - covering - dealing with life through various strategies and facades to live up to the expectations of how to behave as a woman. Living with alcohol dependency as a woman constitutes of a rapid shifting everyday life resulting in senses of alienation as well as private introspection leading to self-degradation, and to a lesser extent meaningfulness and hope. It also constitutes of managing to perform normality. When supporting women with alcohol dependency towards wellbeing, professionals need to work towards approaching the woman's inner thoughts, share them and reflect over them together. To support these women to find balance in life, caregivers need to cooperate with the women to find out how best to live a life adjusted to the woman's abilities and wishes. © 2012 Blackwell Publishing Ltd.

  16. Spectral Envelope Transformation in Singing Voice for Advanced Pitch Shifting

    Directory of Open Access Journals (Sweden)

    José L. Santacruz

    2016-11-01

    Full Text Available The aim of the present work is to perform a step towards more natural pitch shifting techniques in singing voice for its application in music production and entertainment systems. In this paper, we present an advanced method to achieve natural modifications when applying a pitch shifting process to singing voice by modifying the spectral envelope of the audio excerpt. To this end, an all-pole model has been selected to model the spectral envelope, which is estimated using a constrained non-linear optimization. The analysis of the global variations of the spectral envelope was carried out by identifying changes of the parameters of the model along with the changes of the pitch. With the obtained spectral envelope transformation functions, we applied our pitch shifting scheme to some sustained vowels in order to compare results with the same transformation made by using the Flex Pitch plugin of Logic Pro X and pitch synchronous overlap and add technique (PSOLA. This comparison has been carried out by means of both an objective and a subjective evaluation. The latter was done with a survey open to volunteers on our website.

  17. Performance specifications for health physics instrumentation: portable instrumentation for use in normal work environments. Part 2. Test results

    International Nuclear Information System (INIS)

    Kenoyer, J.L.; Swinth, K.L.; Stoetzel, G.A.; Selby, J.M.

    1986-09-01

    The Pacific Northwest Laboratory evaluated a draft American National Standards Institute Standard N42.17 (ANSI N42.17) on performance specifications for health physics instrumentation through a project jointly funded by the US Department of Energy and the US Nuclear Regulatory Commission. The evaluation involved testing a representative cross section of instruments against criteria in the standard. This report presents results of the testing program. A brief history of the project is included in the introduction. The instrumentation tested is described in general terms (i.e., types, ranges); however, no direct relationship between the results and a specific instrument model is made in this report. Testing requirements in ANSI N42.17D4, Revision 1 (May 1985) are summarized and the methods by which the tests are performed are discussed. Brief descriptions of the testing equipment are included in the methods section of the report. More detailed information about the draft standard, testing requirements and procedures, and the test equipment is included in ''Performance Specifications for Health Physics Instrumentation - Portable Instrumentation for Use in Normal Work Environments, Part 1: Manual of Testing Procedures.'' Results of testing are given in two formats: test-by-test and instrument-by-instrument. Discussion is included on significant and interesting findings, on comparisons of results from the same type of instruments from same and different manufacturers, and on data grouped by manufacturer. Conclusions are made on the applicability and practicality of the proposed standard and on instrument performance. Changes that have been made to the proposed standard based on findings of the testing program are listed and discussed. 22 refs., 11 figs., 77 tabs

  18. Predicting word-recognition performance in noise by young listeners with normal hearing using acoustic, phonetic, and lexical variables.

    Science.gov (United States)

    McArdle, Rachel; Wilson, Richard H

    2008-06-01

    To analyze the 50% correct recognition data that were from the Wilson et al (this issue) study and that were obtained from 24 listeners with normal hearing; also to examine whether acoustic, phonetic, or lexical variables can predict recognition performance for monosyllabic words presented in speech-spectrum noise. The specific variables are as follows: (a) acoustic variables (i.e., effective root-mean-square sound pressure level, duration), (b) phonetic variables (i.e., consonant features such as manner, place, and voicing for initial and final phonemes; vowel phonemes), and (c) lexical variables (i.e., word frequency, word familiarity, neighborhood density, neighborhood frequency). The descriptive, correlational study will examine the influence of acoustic, phonetic, and lexical variables on speech recognition in noise performance. Regression analysis demonstrated that 45% of the variance in the 50% point was accounted for by acoustic and phonetic variables whereas only 3% of the variance was accounted for by lexical variables. These findings suggest that monosyllabic word-recognition-in-noise is more dependent on bottom-up processing than on top-down processing. The results suggest that when speech-in-noise testing is used in a pre- and post-hearing-aid-fitting format, the use of monosyllabic words may be sensitive to changes in audibility resulting from amplification.

  19. R Peak Detection Method Using Wavelet Transform and Modified Shannon Energy Envelope.

    Science.gov (United States)

    Park, Jeong-Seon; Lee, Sang-Woong; Park, Unsang

    2017-01-01

    Rapid automatic detection of the fiducial points-namely, the P wave, QRS complex, and T wave-is necessary for early detection of cardiovascular diseases (CVDs). In this paper, we present an R peak detection method using the wavelet transform (WT) and a modified Shannon energy envelope (SEE) for rapid ECG analysis. The proposed WTSEE algorithm performs a wavelet transform to reduce the size and noise of ECG signals and creates SEE after first-order differentiation and amplitude normalization. Subsequently, the peak energy envelope (PEE) is extracted from the SEE. Then, R peaks are estimated from the PEE, and the estimated peaks are adjusted from the input ECG. Finally, the algorithm generates the final R features by validating R-R intervals and updating the extracted R peaks. The proposed R peak detection method was validated using 48 first-channel ECG records of the MIT-BIH arrhythmia database with a sensitivity of 99.93%, positive predictability of 99.91%, detection error rate of 0.16%, and accuracy of 99.84%. Considering the high detection accuracy and fast processing speed due to the wavelet transform applied before calculating SEE, the proposed method is highly effective for real-time applications in early detection of CVDs.

  20. Research on Energy-Saving Optimization for the Performance Parameters of Rural-Building Shape and Envelope by TRNSYS-GenOpt in Hot Summer and Cold Winter Zone of China

    Directory of Open Access Journals (Sweden)

    Shilei Lu

    2017-02-01

    Full Text Available The aim of this paper is to optimize the building shape parameters and envelope parameters influencing the rural building energy consumption in cold winter and hot summer climate. Several typical models are established and optimized by integrated TRNSYS and GenOpt. Single-objective optimization has provided guidance to the multi-dimensional optimization. Building shape and envelope parameters are considered simultaneously by multi-dimensional optimization. Results of the optimization showed significant reduction in terms of EC (energy consumption. When O (building orientation was SW (south by west 10°, LWR (length-width ratio was 1.1, WWRS (window-wall ratio in south with the range of 0.6–0.8, ITE (insulation thickness of exterior wall and ITR (insulation thickness of roof was 0.05 m and 0.08 m respectively, the building had minimal energy consumption. The results also indicated that the optimal EWT (exterior window type was plastic single-frame Low-E insulating glazing filled with inert gas, and the optimal shape of building is Re (rectangle. An effective method was provided to optimize the design of the rural building for the purpose of reducing building energy consumption in cold winter and hot summer climate.

  1. Injection envelope matching in storage rings

    International Nuclear Information System (INIS)

    Minty, M.G.; Spence, W.L.

    1995-05-01

    The shape and size of the transverse phase space injected into a storage ring can be deduced from turn-by-turn measurements of the transient behavior of the beam envelope in the ring. Envelope oscillations at 2 x the β-tron frequency indicate the presence of a β-mismatch, while envelope oscillations at the β-tron frequency are the signature of a dispersion function mismatch. Experiments in injection optimization using synchrotron radiation imaging of the beam and a fast-gated camera at the SLC damping rings are reported

  2. AM Envelope. The potential of Additive Manufacturing for facade constructions

    Directory of Open Access Journals (Sweden)

    Holger Strauss

    2017-11-01

    Full Text Available This dissertation shows the potential of Additive Manufacturing (AM for the development of building envelopes: AM will change the way of designing facades, how we engineer and produce them. To achieve today’s demands from those future envelopes, we have to find new solutions. New technologies offer one possible way to do so. They open new approaches in designing, producing and processing building construction and facades. Finding the one capable of having big impact is difficult – Additive Manufacturing is one possible answer. The term ‘AM Envelope’ (Additive Manufacturing Envelope describes the transfer of this technology to the building envelope. Additive Fabrication is a building block that aids in developing the building envelope from a mere space enclosure to a dynamic building envelope. First beginnings of AM facade construction show up when dealing with relevant aspects like material consumption, mounting or part’s performance. From those starting points several parts of an existing post-and-beam façade system were optimized, aiming toward the implementation of AM into the production chain. Enhancements on all different levels of production were achieved: storing, producing, mounting and performance. AM offers the opportunity to manufacture facades ‘just in time’. It is no longer necessary to store or produce large numbers of parts in advance. Initial investment for tooling can be avoided, as design improvements can be realized within the dataset of the AM part. AM is based on ‘tool-less’ production, all parts can be further developed with every new generation. Producing tool-less also allows for new shapes and functional parts in small batch sizes – down to batch size one. The parts performance can be re-interpreted based on the demands within the system, not based on the limitations of conventional manufacturing. AM offers new ways of materializing the physical part around its function. It leads toward customized

  3. Performance Evaluation of Localization Accuracy for a Log-Normal Shadow Fading Wireless Sensor Network under Physical Barrier Attacks.

    Science.gov (United States)

    Hussein, Ahmed Abdulqader; Rahman, Tharek A; Leow, Chee Yen

    2015-12-04

    Localization is an apparent aspect of a wireless sensor network, which is the focus of much interesting research. One of the severe conditions that needs to be taken into consideration is localizing a mobile target through a dispersed sensor network in the presence of physical barrier attacks. These attacks confuse the localization process and cause location estimation errors. Range-based methods, like the received signal strength indication (RSSI), face the major influence of this kind of attack. This paper proposes a solution based on a combination of multi-frequency multi-power localization (C-MFMPL) and step function multi-frequency multi-power localization (SF-MFMPL), including the fingerprint matching technique and lateration, to provide a robust and accurate localization technique. In addition, this paper proposes a grid coloring algorithm to detect the signal hole map in the network, which refers to the attack-prone regions, in order to carry out corrective actions. The simulation results show the enhancement and robustness of RSS localization performance in the face of log normal shadow fading effects, besides the presence of physical barrier attacks, through detecting, filtering and eliminating the effect of these attacks.

  4. Performance Evaluation of Localization Accuracy for a Log-Normal Shadow Fading Wireless Sensor Network under Physical Barrier Attacks

    Science.gov (United States)

    Abdulqader Hussein, Ahmed; Rahman, Tharek A.; Leow, Chee Yen

    2015-01-01

    Localization is an apparent aspect of a wireless sensor network, which is the focus of much interesting research. One of the severe conditions that needs to be taken into consideration is localizing a mobile target through a dispersed sensor network in the presence of physical barrier attacks. These attacks confuse the localization process and cause location estimation errors. Range-based methods, like the received signal strength indication (RSSI), face the major influence of this kind of attack. This paper proposes a solution based on a combination of multi-frequency multi-power localization (C-MFMPL) and step function multi-frequency multi-power localization (SF-MFMPL), including the fingerprint matching technique and lateration, to provide a robust and accurate localization technique. In addition, this paper proposes a grid coloring algorithm to detect the signal hole map in the network, which refers to the attack-prone regions, in order to carry out corrective actions. The simulation results show the enhancement and robustness of RSS localization performance in the face of log normal shadow fading effects, besides the presence of physical barrier attacks, through detecting, filtering and eliminating the effect of these attacks. PMID:26690159

  5. Constructing canonical bases of quantized enveloping algebras

    OpenAIRE

    Graaf, W.A. de

    2001-01-01

    An algorithm for computing the elements of a given weight of the canonical basis of a quantized enveloping algebra is described. Subsequently, a similar algorithm is presented for computing the canonical basis of a finite-dimensional module.

  6. Evaluation of LWR fuel performance under transient and off-normal conditions. A review of recent reports

    International Nuclear Information System (INIS)

    Knudsen, P.

    1979-11-01

    Reports from the meetings at Petten (Nov. - Dec. 1978), Portland (April-May 1979) and Arles (May 1979) have been reviewed together with various reports related to the Three-Mile Island accident. The reports were selected to cover transients in normal operation (power ramps, load-following) as well as off-normal transients. (author)

  7. Creating a Lunar EVA Work Envelope

    Science.gov (United States)

    Griffin, Brand N.; Howard, Robert; Rajulu, Sudhakar; Smitherman, David

    2009-01-01

    A work envelope has been defined for weightless Extravehicular Activity (EVA) based on the Space Shuttle Extravehicular Mobility Unit (EMU), but there is no equivalent for planetary operations. The weightless work envelope is essential for planning all EVA tasks because it determines the location of removable parts, making sure they are within reach and visibility of the suited crew member. In addition, using the envelope positions the structural hard points for foot restraints that allow placing both hands on the job and provides a load path for reacting forces. EVA operations are always constrained by time. Tasks are carefully planned to ensure the crew has enough breathing oxygen, cooling water, and battery power. Planning first involves computers using a virtual work envelope to model tasks, next suited crew members in a simulated environment refine the tasks. For weightless operations, this process is well developed, but planetary EVA is different and no work envelope has been defined. The primary difference between weightless and planetary work envelopes is gravity. It influences anthropometry, horizontal and vertical mobility, and reaction load paths and introduces effort into doing "overhead" work. Additionally, the use of spacesuits other than the EMU, and their impacts on range of motion, must be taken into account. This paper presents the analysis leading to a concept for a planetary EVA work envelope with emphasis on lunar operations. There is some urgency in creating this concept because NASA has begun building and testing development hardware for the lunar surface, including rovers, habitats and cargo off-loading equipment. Just as with microgravity operations, a lunar EVA work envelope is needed to guide designers in the formative stages of the program with the objective of avoiding difficult and costly rework.

  8. The Arabidopsis Nuclear Pore and Nuclear Envelope

    OpenAIRE

    Meier, Iris; Brkljacic, Jelena

    2010-01-01

    The nuclear envelope is a double membrane structure that separates the eukaryotic cytoplasm from the nucleoplasm. The nuclear pores embedded in the nuclear envelope are the sole gateways for macromolecular trafficking in and out of the nucleus. The nuclear pore complexes assembled at the nuclear pores are large protein conglomerates composed of multiple units of about 30 different nucleoporins. Proteins and RNAs traffic through the nuclear pore complexes, enabled by the interacting activities...

  9. Cost Analysis of Simple Phase Change Material-Enhanced Building Envelopes in Southern U.S. Climates

    Energy Technology Data Exchange (ETDEWEB)

    Kosny, Jan [Fraunhofer CSE, Cambridge, MA (United States); Shukla, Nitin [Fraunhofer CSE, Cambridge, MA (United States); Fallahi, Ali [Fraunhofer CSE, Cambridge, MA (United States)

    2013-01-01

    Traditional thermal designs of building envelope assemblies are based on static energy flows, yet building envelopes are subject to varying environmental conditions. This mismatch between the steady-state principles and their dynamic operation can decrease thermal efficiency. Design work supporting the development of low-energy houses showed that conventional insulations may not always be the most cost effective solution to improvement envelope thermal performance. PCM-enhanced building envelopes that simultaneously reduce the total cooling loads and shift the peak-hour loads are the focus of this report.

  10. All the Universe in an envelope

    CERN Multimedia

    2007-01-01

    Do you know which force is hidden in an envelope or how many billions of years old are the atoms it contains? You will find the answers to these (curious) questions in a post office in the Pays de Gex. The French postal services of the Pays de Gex are again issuing pre-paid envelopes in collaboration with CERN (see Bulletin No. 24/2006). The new series presents some of the concepts of modern physics in an amazing way by showing what you can learn about the Universe with a single envelope. Packets of ten pre-stamped envelopes, each carrying a statement on fundamental physics, will be on sale from 7 July onwards. To learn more about the physics issues presented on the envelopes, people are invited to go to the CERN Web site where they will find the explanations. Five thousand envelopes will be put on sale in July and five thousand more during the French "Fête de la science" in October. They will be available from five post offices in the Pays de Gex (F...

  11. Genetic Diversity of Koala Retroviral Envelopes

    Directory of Open Access Journals (Sweden)

    Wenqin Xu

    2015-03-01

    Full Text Available Genetic diversity, attributable to the low fidelity of reverse transcription, recombination and mutation, is an important feature of infectious retroviruses. Under selective pressure, such as that imposed by superinfection interference, gammaretroviruses commonly adapt their envelope proteins to use alternative receptors to overcome this entry block. The first characterized koala retroviruses KoRV subgroup A (KoRV-A were remarkable in their absence of envelope genetic variability. Once it was determined that KoRV-A was present in all koalas in US zoos, regardless of their disease status, we sought to isolate a KoRV variant whose presence correlated with neoplastic malignancies. More than a decade after the identification of KoRV-A, we isolated a second subgroup of KoRV, KoRV-B from koalas with lymphomas. The envelope proteins of KoRV-A and KoRV-B are sufficiently divergent to confer the ability to bind and employ distinct receptors for infection. We have now obtained a number of additional KoRV envelope variants. In the present studies we report these variants, and show that they differ from KoRV-A and KoRV-B envelopes in their host range and superinfection interference properties. Thus, there appears to be considerable variation among KoRVs envelope genes suggesting genetic diversity is a factor following the KoRV-A infection process.

  12. Biodegradable drug-eluting nanofiber-enveloped implants for sustained release of high bactericidal concentrations of vancomycin and ceftazidime: in vitro and in vivo studies

    Directory of Open Access Journals (Sweden)

    Hsu YH

    2014-09-01

    Full Text Available Yung-Heng Hsu,1,2 Dave Wei-Chih Chen,1 Chun-Der Tai,3 Ying-Chao Chou,1,2 Shih-Jung Liu,2 Steve Wen-Neng Ueng,1 Err-Cheng Chan4 1Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Guishan Township, 2Department of Mechanical Engineering, Chang Gung University, Guishan Township, 3Graduate Institute of Medical Mechatronics, Chang Gung University, Guishan Township, 4School of Medical Technology, Chang Gung University, Guishan Township, Taiwan Abstract: We developed biodegradable drug-eluting nanofiber-enveloped implants that provided sustained release of vancomycin and ceftazidime. To prepare the biodegradable nanofibrous membranes, poly(D,L-lactide-co-glycolide and the antibiotics were first dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol. They were electrospun into biodegradable drug-eluting membranes, which were then enveloped on the surface of stainless plates. An elution method and a high-performance liquid chromatography assay were employed to characterize the in vivo and in vitro release rates of the antibiotics from the nanofiber-enveloped plates. The results showed that the biodegradable nanofiber-enveloped plates released high concentrations of vancomycin and ceftazidime (well above the minimum inhibitory concentration for more than 3 and 8 weeks in vitro and in vivo, respectively. A bacterial inhibition test was carried out to determine the relative activity of the released antibiotics. The bioactivity ranged from 25% to 100%. In addition, the serum creatinine level remained within the normal range, suggesting that the high vancomycin concentration did not affect renal function. By adopting the electrospinning technique, we will be able to manufacture biodegradable drug-eluting implants for the long-term drug delivery of different antibiotics. Keywords: biodegradable nanofiber-enveloped plates, electrospinning, antibiotics, release characteristics

  13. Gravitational Waves from Accreting Neutron Stars Undergoing Common-envelope Inspiral

    Science.gov (United States)

    Holgado, A. Miguel; Ricker, Paul M.; Huerta, E. A.

    2018-04-01

    The common-envelope phase is a likely formation channel for close binary systems containing compact objects. Neutron stars in common envelopes accrete at a fraction of the Bondi–Hoyle–Lyttleton accretion rate, since the stellar envelope is inhomogeneous, but they may still be able to accrete at hypercritical rates (though not enough to become black holes). We show that common-envelope systems consisting of a neutron star with a massive primary may be gravitational-wave (GW) sources detectable in the Advanced LIGO band as far away as the Magellanic Clouds. To characterize their evolution, we perform orbital integrations using 1D models of 12 M ⊙ and 20 M ⊙ primaries, considering the effects of density gradient on the accretion onto the NS and spin evolution. From the range of possible accretion rates relevant to common-envelope evolution, we find that these systems may be louder GW sources than low-mass X-ray binaries like Sco X-1, which are currently the target of directed searches for continuous GWs. We also find that their strain amplitude signal may allow for novel constraints on the orbital separation and inspiral timescale in common envelopes when combined with pre-common-envelope electromagnetic observations.

  14. An Assessment of Envelope Measures in Mild Climate Deep Energy Retrofits

    Energy Technology Data Exchange (ETDEWEB)

    Walker, Iain [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Less, Brennan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2014-06-01

    Energy end-uses and interior comfort conditions have been monitored in 11 Deep Energy Retrofits (DERs) in a mild marine climate. Two broad categories of DER envelope were identified: first, bringing homes up to current code levels of insulation and airtightness, and second, enhanced retrofits that go beyond these code requirements. The efficacy of envelope measures in DERs was difficult to determine, due to the intermingled effects of enclosure improvements, HVAC system upgrades and changes in interior comfort conditions. While energy reductions in these project homes could not be assigned to specific improvements, the combined effects of changes in enclosure, HVAC system and comfort led to average heating energy reductions of 76percent (12,937 kWh) in the five DERs with pre-retrofit data, or 80percent (5.9 kWh/ft2) when normalized by floor area. Overall, net-site energy reductions averaged 58percent (15,966 kWh; n=5), and DERs with code-style envelopes achieved average net-site energy reductions of 65percent (18,923 kWh; n=4). In some homes, the heating energy reductions were actually larger than the whole house reductions that were achieved, which suggests that substantial additional energy uses were added to the home during the retrofit that offset some heating savings. Heating system operation and energy use was shown to vary inconsistently with outdoor conditions, suggesting that most DERs were not thermostatically controlled and that occupants were engaged in managing the indoor environmental conditions. Indoor temperatures maintained in these DERs were highly variable, and no project home consistently provided conditions within the ASHRAE Standard 55-2010 heating season comfort zone. Thermal comfort and heating system operation had a large impact on performance and were found to depend upon the occupant activities, so DERs should be designed with the occupants needs and patterns of consumption in mind. Beyond-code building envelopes were not found to be

  15. Interior thermal insulation systems for historical building envelopes

    Science.gov (United States)

    Jerman, Miloš; Solař, Miloš; Černý, Robert

    2017-11-01

    The design specifics of interior thermal insulation systems applied for historical building envelopes are described. The vapor-tight systems and systems based on capillary thermal insulation materials are taken into account as two basic options differing in building-physical considerations. The possibilities of hygrothermal analysis of renovated historical envelopes including laboratory methods, computer simulation techniques, and in-situ tests are discussed. It is concluded that the application of computational models for hygrothermal assessment of interior thermal insulation systems should always be performed with a particular care. On one hand, they present a very effective tool for both service life assessment and possible planning of subsequent reconstructions. On the other, the hygrothermal analysis of any historical building can involve quite a few potential uncertainties which may affect negatively the accuracy of obtained results.

  16. Solitary Alfven wave envelopes and the modulational instability

    International Nuclear Information System (INIS)

    Kennel, C.F.

    1987-06-01

    The derivative nonlinear Schroedinger equation describes the modulational instability of circularly polarized dispersive Alfven wave envelopes. It also may be used to determine the properties of finite amplitude localized stationary wave envelopes. Such envelope solitons exist only in conditions of modulational stability. This leaves open the question of whether, and if so, how, the modulational instability produces envelope solitons. 12 refs

  17. Experiences when employing different alternatives for envelope upgrading

    Directory of Open Access Journals (Sweden)

    Peru Elguezabal Esnarrizaga

    2015-06-01

    Full Text Available The challenges of achieving the 2020 goals in terms of energy savings and improving efficiency are guiding numerous research initiatives looking for more insulated envelopes, dealing with thermal performance of insulation materials and envelope systems. Nevertheless, the envelope integrates within the building and this improvement on the insulation performance has to be properly adopted, taking into account the interrelation of main elements composing the overall system (facade, frame, slabs, openings, partitions etc., as well as side effects originated not only for new erected buildings, but specifically in renovation and retrofitting works. This paper describes real experiences when considering various options for upgrading the facade through the increase of the insulation capacity, starting from external overcladding prefabricated panels and ventilated facades, advancing to more sustainable low carbon systems and ending with even more highly insulated solutions employing aerogels. Lessons from these cases, where energy and hygrothermal assessments have being carried out, demonstrate the influence of the design and construction phases and the relevance of disregarded effects such as minor thermal bridges, uncontrolled craftsmanship on site, and moisture transfer for the different technologies considered. Finally, possible alternatives are provided to overcome some of the detected difficulties, such as combination with non-metallic structural components and building membranes, and being prepared for future challenges and new developments when these isolative elements are combined with other technologies, as for example, renewable energy harvesting devices.  

  18. Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins

    Energy Technology Data Exchange (ETDEWEB)

    Maric, Martina; Haugo, Alison C. [Department of Microbiology, University of Iowa, Iowa City, IA 52242 (United States); Dauer, William [Department of Neurology, University of Michigan, Ann Arbor, MI 48109 (United States); Johnson, David [Department of Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97201 (United States); Roller, Richard J., E-mail: richard-roller@uiowa.edu [Department of Microbiology, University of Iowa, Iowa City, IA 52242 (United States)

    2014-07-15

    Herpesvirus infection reorganizes components of the nuclear lamina usually without loss of integrity of the nuclear membranes. We report that wild-type HSV infection can cause dissolution of the nuclear envelope in transformed mouse embryonic fibroblasts that do not express torsinA. Nuclear envelope breakdown is accompanied by an eight-fold inhibition of virus replication. Breakdown of the membrane is much more limited during infection with viruses that lack the gB and gH genes, suggesting that breakdown involves factors that promote fusion at the nuclear membrane. Nuclear envelope breakdown is also inhibited during infection with virus that does not express UL34, but is enhanced when the US3 gene is deleted, suggesting that envelope breakdown may be enhanced by nuclear lamina disruption. Nuclear envelope breakdown cannot compensate for deletion of the UL34 gene suggesting that mixing of nuclear and cytoplasmic contents is insufficient to bypass loss of the normal nuclear egress pathway. - Highlights: • We show that wild-type HSV can induce breakdown of the nuclear envelope in a specific cell system. • The viral fusion proteins gB and gH are required for induction of nuclear envelope breakdown. • Nuclear envelope breakdown cannot compensate for deletion of the HSV UL34 gene.

  19. Study of an experimental methodology for thermal properties diagnostic of building envelop

    OpenAIRE

    Yang , Yingying; Sempey , Alain; Vogt Wu , Tingting; Sommier , Alain; Dumoulin , Jean; Batsale , Jean ,

    2017-01-01

    International audience; The building envelope plays a critical role in determining levels of comfort and building efficiency. Its real thermal properties characterization is of major interest to be able to diagnose energy efficiency performance of buildings (new construction and retrofitted existing old building). Research and development on a possible methodology for energy diagnostic of the building envelop is a hot topic and necessary trend. Many kinds of sensors and instruments are used f...

  20. Extended Cann Model for Behavioral Modeling of Envelope Tracking Power Amplifiers

    DEFF Research Database (Denmark)

    Tafuri, Felice Francesco; Larsen, Torben

    2013-01-01

    This paper deals with behavioral modeling of power amplifiers (PAs) for envelope tracking (ET) applications. In such a scenario, the power supply modulation brings in several additional challenges for the system design and, similarly, it becomes more difficult to obtain an accurate and general PA...... by the ET operation. The model performance is tested modeling data-sets acquired from an ET test bench including a commercial RFMD PA and an envelope modulator designed using a commercial IC from TI....

  1. Genetic algorithm for building envelope calibration

    International Nuclear Information System (INIS)

    Ramos Ruiz, Germán; Fernández Bandera, Carlos; Gómez-Acebo Temes, Tomás; Sánchez-Ostiz Gutierrez, Ana

    2016-01-01

    Highlights: • Calibration methodology using Multi-Objective Genetic Algorithm (NSGA-II). • Uncertainty analysis formulas implemented directly in EnergyPlus. • The methodology captures the heat dynamic of the building with a high level of accuracy. • Reduction in the number of parameters involved due to sensitivity analysis. • Cost-effective methodology using temperature sensors only. - Abstract: Buildings today represent 40% of world primary energy consumption and 24% of greenhouse gas emissions. In our society there is growing interest in knowing precisely when and how energy consumption occurs. This means that consumption measurement and verification plans are well-advanced. International agencies such as Efficiency Valuation Organization (EVO) and International Performance Measurement and Verification Protocol (IPMVP) have developed methodologies to quantify savings. This paper presents a methodology to accurately perform automated envelope calibration under option D (calibrated simulation) of IPMVP – vol. 1. This is frequently ignored because of its complexity, despite being more flexible and accurate in assessing the energy performance of a building. A detailed baseline energy model is used, and by means of a metaheuristic technique achieves a highly reliable and accurate Building Energy Simulation (BES) model suitable for detailed analysis of saving strategies. In order to find this BES model a Genetic Algorithm (NSGA-II) is used, together with a highly efficient engine to stimulate the objective, thus permitting rapid achievement of the goal. The result is a BES model that broadly captures the heat dynamic behaviour of the building. The model amply fulfils the parameters demanded by ASHRAE and EVO under option D.

  2. Comparing the information conveyed by envelope modulation for speech intelligibility, speech quality, and music quality.

    Science.gov (United States)

    Kates, James M; Arehart, Kathryn H

    2015-10-01

    This paper uses mutual information to quantify the relationship between envelope modulation fidelity and perceptual responses. Data from several previous experiments that measured speech intelligibility, speech quality, and music quality are evaluated for normal-hearing and hearing-impaired listeners. A model of the auditory periphery is used to generate envelope signals, and envelope modulation fidelity is calculated using the normalized cross-covariance of the degraded signal envelope with that of a reference signal. Two procedures are used to describe the envelope modulation: (1) modulation within each auditory frequency band and (2) spectro-temporal processing that analyzes the modulation of spectral ripple components fit to successive short-time spectra. The results indicate that low modulation rates provide the highest information for intelligibility, while high modulation rates provide the highest information for speech and music quality. The low-to-mid auditory frequencies are most important for intelligibility, while mid frequencies are most important for speech quality and high frequencies are most important for music quality. Differences between the spectral ripple components used for the spectro-temporal analysis were not significant in five of the six experimental conditions evaluated. The results indicate that different modulation-rate and auditory-frequency weights may be appropriate for indices designed to predict different types of perceptual relationships.

  3. Operating envelope to minimize probability of fractures in Zircaloy-2 pressure tubes

    International Nuclear Information System (INIS)

    Azer, N.; Wong, H.

    1994-01-01

    The failure mode of primary concern with Candu pressure tubes is fast fracture of a through-wall axial crack, resulting from delayed hydride crack growth. The application of operating envelopes is demonstrated to minimize the probability of fracture in Zircaloy-2 pressure tubes based on Zr-2.5%Nb pressure tube experience. The technical basis for the development of the operating envelopes is also summarized. The operating envelope represents an area on the pressure versus temperature diagram within which the reactor may be operated without undue concern for pressure tube fracture. The envelopes presented address both normal operating conditions and the condition where a pressure tube leak has been detected. The examples in this paper are prepared to illustrate the methodology, and are not intended to be directly applicable to the operation of any specific reactor. The application of operating envelopes to minimized the probability of fracture in 80 mm diameter Zircaloy-2 pressure tubes has been discussed. Both normal operating and leaking pressure tube conditions have been considered. 3 refs., 4 figs

  4. The Contribution of Matched Envelope Dynamic Range to the Binaural Benefits in Simulated Bilateral Electric Hearing

    Science.gov (United States)

    Chen, Fei; Wong, Lena L. N.; Qiu, Jianxin; Liu, Yehai; Azimi, Behnam; Hu, Yi

    2013-01-01

    Purpose: This study examined the effects of envelope dynamic-range mismatch on the intelligibility of Mandarin speech in noise by simulated bilateral electric hearing. Method: Noise-vocoded Mandarin speech, corrupted by speech-shaped noise at 5 and 0 dB signal-to-noise ratios, was presented unilaterally or bilaterally to 10 normal-hearing…

  5. Meta-analysis of prediction model performance across multiple studies: Which scale helps ensure between-study normality for the C-statistic and calibration measures?

    Science.gov (United States)

    Snell, Kym Ie; Ensor, Joie; Debray, Thomas Pa; Moons, Karel Gm; Riley, Richard D

    2017-01-01

    If individual participant data are available from multiple studies or clusters, then a prediction model can be externally validated multiple times. This allows the model's discrimination and calibration performance to be examined across different settings. Random-effects meta-analysis can then be used to quantify overall (average) performance and heterogeneity in performance. This typically assumes a normal distribution of 'true' performance across studies. We conducted a simulation study to examine this normality assumption for various performance measures relating to a logistic regression prediction model. We simulated data across multiple studies with varying degrees of variability in baseline risk or predictor effects and then evaluated the shape of the between-study distribution in the C-statistic, calibration slope, calibration-in-the-large, and E/O statistic, and possible transformations thereof. We found that a normal between-study distribution was usually reasonable for the calibration slope and calibration-in-the-large; however, the distributions of the C-statistic and E/O were often skewed across studies, particularly in settings with large variability in the predictor effects. Normality was vastly improved when using the logit transformation for the C-statistic and the log transformation for E/O, and therefore we recommend these scales to be used for meta-analysis. An illustrated example is given using a random-effects meta-analysis of the performance of QRISK2 across 25 general practices.

  6. Inhibition of enveloped viruses infectivity by curcumin.

    Directory of Open Access Journals (Sweden)

    Tzu-Yen Chen

    Full Text Available Curcumin, a natural compound and ingredient in curry, has antiinflammatory, antioxidant, and anticarcinogenic properties. Previously, we reported that curcumin abrogated influenza virus infectivity by inhibiting hemagglutination (HA activity. This study demonstrates a novel mechanism by which curcumin inhibits the infectivity of enveloped viruses. In all analyzed enveloped viruses, including the influenza virus, curcumin inhibited plaque formation. In contrast, the nonenveloped enterovirus 71 remained unaffected by curcumin treatment. We evaluated the effects of curcumin on the membrane structure using fluorescent dye (sulforhodamine B; SRB-containing liposomes that mimic the viral envelope. Curcumin treatment induced the leakage of SRB from these liposomes and the addition of the influenza virus reduced the leakage, indicating that curcumin disrupts the integrity of the membranes of viral envelopes and of liposomes. When testing liposomes of various diameters, we detected higher levels of SRB leakage from the smaller-sized liposomes than from the larger liposomes. Interestingly, the curcumin concentration required to reduce plaque formation was lower for the influenza virus (approximately 100 nm in diameter than for the pseudorabies virus (approximately 180 nm and the vaccinia virus (roughly 335 × 200 × 200 nm. These data provide insights on the molecular antiviral mechanisms of curcumin and its potential use as an antiviral agent for enveloped viruses.

  7. Inhibition of Enveloped Viruses Infectivity by Curcumin

    Science.gov (United States)

    Wen, Hsiao-Wei; Ou, Jun-Lin; Chiou, Shyan-Song; Chen, Jo-Mei; Wong, Min-Liang; Hsu, Wei-Li

    2013-01-01

    Curcumin, a natural compound and ingredient in curry, has antiinflammatory, antioxidant, and anticarcinogenic properties. Previously, we reported that curcumin abrogated influenza virus infectivity by inhibiting hemagglutination (HA) activity. This study demonstrates a novel mechanism by which curcumin inhibits the infectivity of enveloped viruses. In all analyzed enveloped viruses, including the influenza virus, curcumin inhibited plaque formation. In contrast, the nonenveloped enterovirus 71 remained unaffected by curcumin treatment. We evaluated the effects of curcumin on the membrane structure using fluorescent dye (sulforhodamine B; SRB)-containing liposomes that mimic the viral envelope. Curcumin treatment induced the leakage of SRB from these liposomes and the addition of the influenza virus reduced the leakage, indicating that curcumin disrupts the integrity of the membranes of viral envelopes and of liposomes. When testing liposomes of various diameters, we detected higher levels of SRB leakage from the smaller-sized liposomes than from the larger liposomes. Interestingly, the curcumin concentration required to reduce plaque formation was lower for the influenza virus (approximately 100 nm in diameter) than for the pseudorabies virus (approximately 180 nm) and the vaccinia virus (roughly 335 × 200 × 200 nm). These data provide insights on the molecular antiviral mechanisms of curcumin and its potential use as an antiviral agent for enveloped viruses. PMID:23658730

  8. Multiobjective optimization design of green building envelope material using a non-dominated sorting genetic algorithm

    International Nuclear Information System (INIS)

    Yang, Ming-Der; Lin, Min-Der; Lin, Yu-Hao; Tsai, Kang-Ting

    2017-01-01

    Highlights: • An effective envelope energy performance model (BEM) was developed. • We integrated NSGA-II with the BEM to optimize the green building envelope. • A tradeoff plan of green building design for three conflict objectives was obtained. • The optimal envelope design efficiently reduced the construction cost of green building. - Abstract: To realize the goal of environmental sustainability, improving energy efficiency in buildings is a major priority worldwide. However, the practical design of green building envelopes for energy conservation is a highly complex optimization problem, and architects must make multiobjective decisions. In practice, methods such as multicriteria analyses that entail capitalizing on possibly many (but in nearly any case limited) alternatives are commonly employed. This study investigated the feasibility of applying a multiobjective optimal model on building envelope design (MOPBEM), which involved integrating a building envelope energy performance model with a multiobjective optimizer. The MOPBEM was established to provide a reference for green designs. A nondominated sorting genetic algorithm-II (NSGA-II) was used to achieve a tradeoff design set between three conflicting objectives, namely minimizing the envelope construction cost (ENVCOST), minimizing the envelope energy performance (ENVLOAD), and maximizing the window opening rate (WOPR). A real office building case was designed using the MOPBEM to identify the potential strengths and weaknesses of the proposed MOPBEM. The results showed that a high ENVCOST was expended in simultaneously satisfying the low ENVLOAD and high WOPR. Various designs exhibited obvious cost reductions compared with the original architects' manual design, demonstrating the practicability of the MOPBEM.

  9. Left ventricular diastolic performance at rest in patients with angina and normal systolic function - assessment by equilibrium radionuclide angiography

    International Nuclear Information System (INIS)

    Maini, C.L.; Bonetti, M.G.; Valle, G.; Antonelli Incalzi, R.; Montenero, A.S.

    1985-01-01

    The aim of the study was to correlate diastolic function, as evaluated by peak filling rate (PFR) and relative time (TPFR), with the severity of ischemic heart disease, as evaluated by exercise electrocardiography. Accordingly, 83 ischemic patients with effort angina, but normal ejection function at rest and normal left ventricular size, were studied by equilibrium radionuclide angiocardiography within two weeks from the exercise ECG. Diastolic dysfunction, as determined from PFR and, to a lesser extent, from TPFR, is common in patients with ischemic heart disease and normal systolic function. The prevalence and severity of such dysfunction is related more to the severity of the ischemia, as evaluated by the exercise ECG, than to the presence of an old myocardial infarction. Such findings are consistent with the hypothesis that PFR reflects mainly the early diastolic active uncoupling process. (orig.) [de

  10. Addition of arginine and leucine to low or normal protein diets: performance, carcass characteristics and intramuscular fat of finishing pigs

    Directory of Open Access Journals (Sweden)

    Núria Tous

    2016-12-01

    Full Text Available The effect of dietary crude protein (CP reduction, supplementation with arginine or leucine on intramuscular fat (IMF content was evaluated in (Landrace × Duroc × Pietrain pigs. One-hundred and eight barrows (67 ± 4 kg were assigned to six diets (n=6 pens of 3 pigs each: four normal CP diets containing 16% CP from 60 to 90 kg and 13% CP from 90 to 115 kg live weight (normal protein; normal protein high Arg, normal protein high Leu or normal protein high Arg and Leu and two low CP diets containing 14% CP from 60 to 90 kg and 11.8% CP from 90 to 115 kg live weight (with or without supplementation of both amino acids. The high Leu and Arg diets were supplemented to obtain ratios of standard ileal digestible Leu/Lys and Arg/Lys of 4 and 2, respectively. While feed to gain ratio tended to increase (p<0.05, final weight (p<0.01, average daily feed intake (ADFI (p<0.05 and average daily gain (ADG (p<0.01 were reduced in animals fed low-protein diets supplemented with Arg and Leu compared to the ones fed low-protein diet unsupplemented. Marbling and IMF content in loin were reduced when Arg was supplemented (p<0.05 in normal protein diets. Supplementing these diets with Arg also reduced belly weight (p<0.01 and increased lean meat percentage (p<0.05. Contrary to the initial hypothesis, reduction of CP or dietary supplementation with Leu had no effect on IMF content and supplementation with Arg reduced it.

  11. Addition of arginine and leucine to low or normal protein diets: performance, carcass characteristics and intramuscular fat of finishing pigs

    Energy Technology Data Exchange (ETDEWEB)

    Tous, N.; Lizardo, R.; Vilà, B.; Gispert, M.; Font-i-Furnols, M.; Esteve-Garcia, E.

    2016-07-01

    The effect of dietary crude protein (CP) reduction, supplementation with arginine or leucine on intramuscular fat (IMF) content was evaluated in (Landrace × Duroc) × Pietrain pigs. One-hundred and eight barrows (67 ± 4 kg) were assigned to six diets (n=6 pens of 3 pigs each): four normal CP diets containing 16% CP from 60 to 90 kg and 13% CP from 90 to 115 kg live weight (normal protein; normal protein high Arg, normal protein high Leu or normal protein high Arg and Leu) and two low CP diets containing 14% CP from 60 to 90 kg and 11.8% CP from 90 to 115 kg live weight (with or without supplementation of both amino acids). The high Leu and Arg diets were supplemented to obtain ratios of standard ileal digestible Leu/Lys and Arg/Lys of 4 and 2, respectively. While feed to gain ratio tended to increase (p<0.05), final weight (p<0.01), average daily feed intake (ADFI) (p<0.05) and average daily gain (ADG) (p<0.01) were reduced in animals fed low-protein diets supplemented with Arg and Leu compared to the ones fed low-protein diet unsupplemented. Marbling and IMF content in loin were reduced when Arg was supplemented (p<0.05) in normal protein diets. Supplementing these diets with Arg also reduced belly weight (p<0.01) and increased lean meat percentage (p<0.05). Contrary to the initial hypothesis, reduction of CP or dietary supplementation with Leu had no effect on IMF content and supplementation with Arg reduced it.

  12. Addition of arginine and leucine to low or normal protein diets: performance, carcass characteristics and intramuscular fat of finishing pigs

    International Nuclear Information System (INIS)

    Tous, N.; Lizardo, R.; Vilà, B.; Gispert, M.; Font-i-Furnols, M.; Esteve-Garcia, E.

    2016-01-01

    The effect of dietary crude protein (CP) reduction, supplementation with arginine or leucine on intramuscular fat (IMF) content was evaluated in (Landrace × Duroc) × Pietrain pigs. One-hundred and eight barrows (67 ± 4 kg) were assigned to six diets (n=6 pens of 3 pigs each): four normal CP diets containing 16% CP from 60 to 90 kg and 13% CP from 90 to 115 kg live weight (normal protein; normal protein high Arg, normal protein high Leu or normal protein high Arg and Leu) and two low CP diets containing 14% CP from 60 to 90 kg and 11.8% CP from 90 to 115 kg live weight (with or without supplementation of both amino acids). The high Leu and Arg diets were supplemented to obtain ratios of standard ileal digestible Leu/Lys and Arg/Lys of 4 and 2, respectively. While feed to gain ratio tended to increase (p<0.05), final weight (p<0.01), average daily feed intake (ADFI) (p<0.05) and average daily gain (ADG) (p<0.01) were reduced in animals fed low-protein diets supplemented with Arg and Leu compared to the ones fed low-protein diet unsupplemented. Marbling and IMF content in loin were reduced when Arg was supplemented (p<0.05) in normal protein diets. Supplementing these diets with Arg also reduced belly weight (p<0.01) and increased lean meat percentage (p<0.05). Contrary to the initial hypothesis, reduction of CP or dietary supplementation with Leu had no effect on IMF content and supplementation with Arg reduced it.

  13. Envelope model for passive magnetic focusing of an intense proton or ion beam propagating through thin foils

    Directory of Open Access Journals (Sweden)

    Steven M. Lund

    2013-04-01

    Full Text Available Ion beams (including protons with low emittance and high space-charge intensity can be propagated with normal incidence through a sequence of thin metallic foils separated by vacuum gaps of order the characteristic transverse beam extent to transport/collimate the beam or to focus it to a small transverse spot. Energetic ions have sufficient range to pass through a significant number of thin foils with little energy loss or scattering. The foils reduce the (defocusing radial electric self-field of the beam while not altering the (focusing azimuthal magnetic self-field of the beam, thereby allowing passive self-beam focusing if the magnetic field is sufficiently strong relative to the residual electric field. Here we present an envelope model developed to predict the strength of this passive (beam generated focusing effect under a number of simplifying assumptions including relatively long pulse duration. The envelope model provides a simple criterion for the necessary foil spacing for net focusing and clearly illustrates system focusing properties for either beam collimation (such as injecting a laser-produced proton beam into an accelerator or for magnetic pinch focusing to a small transverse spot (for beam driven heating of materials. An illustrative example is worked for an idealization of a recently performed laser-produced proton-beam experiment to provide guidance on possible beam focusing and collimation systems. It is found that foils spaced on the order of the characteristic transverse beam size desired can be employed and that envelope divergence of the initial beam entering the foil lens must be suppressed to limit the total number of foils required to practical values for pinch focusing. Relatively modest proton-beam current at 10 MeV kinetic energy can clearly demonstrate strong magnetic pinch focusing achieving a transverse rms extent similar to the foil spacing (20–50  μm gaps in beam propagation distances of tens of mm

  14. Analytical study of envelope modes for a fully depressed beam in solenoidal and quadrupole periodic transport channels

    International Nuclear Information System (INIS)

    Bukh, Boris; Lund, Steven M.

    2003-01-01

    We present an analysis of envelope perturbations evolving in the limit of a fully space-charge depressed (zero emittance) beam in periodic, thin-lens focusing channels. Both periodic solenoidal and FODO quadrupole focusing channels are analyzed. The phase advance and growth rate of normal mode perturbations are analytically calculated as a function of the undepressed particle phase advance to characterize the evolution of envelope perturbations

  15. Genetic Interaction Maps in Escherichia coli Reveal Functional Crosstalk among Cell Envelope Biogenesis Pathways

    Science.gov (United States)

    Vlasblom, James; Gagarinova, Alla; Phanse, Sadhna; Graham, Chris; Yousif, Fouad; Ding, Huiming; Xiong, Xuejian; Nazarians-Armavil, Anaies; Alamgir, Md; Ali, Mehrab; Pogoutse, Oxana; Pe'er, Asaf; Arnold, Roland; Michaut, Magali; Parkinson, John; Golshani, Ashkan; Whitfield, Chris; Wodak, Shoshana J.; Moreno-Hagelsieb, Gabriel; Greenblatt, Jack F.; Emili, Andrew

    2011-01-01

    As the interface between a microbe and its environment, the bacterial cell envelope has broad biological and clinical significance. While numerous biosynthesis genes and pathways have been identified and studied in isolation, how these intersect functionally to ensure envelope integrity during adaptive responses to environmental challenge remains unclear. To this end, we performed high-density synthetic genetic screens to generate quantitative functional association maps encompassing virtually the entire cell envelope biosynthetic machinery of Escherichia coli under both auxotrophic (rich medium) and prototrophic (minimal medium) culture conditions. The differential patterns of genetic interactions detected among >235,000 digenic mutant combinations tested reveal unexpected condition-specific functional crosstalk and genetic backup mechanisms that ensure stress-resistant envelope assembly and maintenance. These networks also provide insights into the global systems connectivity and dynamic functional reorganization of a universal bacterial structure that is both broadly conserved among eubacteria (including pathogens) and an important target. PMID:22125496

  16. Genetic interaction maps in Escherichia coli reveal functional crosstalk among cell envelope biogenesis pathways.

    Directory of Open Access Journals (Sweden)

    Mohan Babu

    2011-11-01

    Full Text Available As the interface between a microbe and its environment, the bacterial cell envelope has broad biological and clinical significance. While numerous biosynthesis genes and pathways have been identified and studied in isolation, how these intersect functionally to ensure envelope integrity during adaptive responses to environmental challenge remains unclear. To this end, we performed high-density synthetic genetic screens to generate quantitative functional association maps encompassing virtually the entire cell envelope biosynthetic machinery of Escherichia coli under both auxotrophic (rich medium and prototrophic (minimal medium culture conditions. The differential patterns of genetic interactions detected among > 235,000 digenic mutant combinations tested reveal unexpected condition-specific functional crosstalk and genetic backup mechanisms that ensure stress-resistant envelope assembly and maintenance. These networks also provide insights into the global systems connectivity and dynamic functional reorganization of a universal bacterial structure that is both broadly conserved among eubacteria (including pathogens and an important target.

  17. Computation of Phase Equilibrium and Phase Envelopes

    DEFF Research Database (Denmark)

    Ritschel, Tobias Kasper Skovborg; Jørgensen, John Bagterp

    formulate the involved equations in terms of the fugacity coefficients. We present expressions for the first-order derivatives. Such derivatives are necessary in computationally efficient gradient-based methods for solving the vapor-liquid equilibrium equations and for computing phase envelopes. Finally, we......In this technical report, we describe the computation of phase equilibrium and phase envelopes based on expressions for the fugacity coefficients. We derive those expressions from the residual Gibbs energy. We consider 1) ideal gases and liquids modeled with correlations from the DIPPR database...... and 2) nonideal gases and liquids modeled with cubic equations of state. Next, we derive the equilibrium conditions for an isothermal-isobaric (constant temperature, constant pressure) vapor-liquid equilibrium process (PT flash), and we present a method for the computation of phase envelopes. We...

  18. Boundaries, injective envelopes, and reduced crossed products

    DEFF Research Database (Denmark)

    Bryder, Rasmus Sylvester

    In this dissertation, we study boundary actions, equivariant injective envelopes, as well as theideal structure of reduced crossed products. These topics have recently been linked to thestudy of C-simple groups, that is, groups with simple reduced group C-algebras.In joint work with Matthew Kennedy......, we consider reduced twisted crossed products overC-simple groups. For any twisted C-dynamical system over a C-simple group, we provethat there is a one-to-one correspondence between maximal invariant ideals in the underlyingC-algebra and maximal ideals in the reduced crossed product. When......*-algebras, and relate the intersection property for group actions on unital C*-algebras to the intersection property for theequivariant injective envelope. Moreover, we also prove that the equivariant injective envelopeof the centre of the injective envelope of a unital C*-algebra can be regarded as a C...

  19. A study of some Be star envelopes

    International Nuclear Information System (INIS)

    Kitchen, C.R.

    1976-01-01

    The envelope model and emission region radius of six Be stars have been determined from 36 lines on 15 spectra taken with the Isaac Newton telescope. The results have been compared with earlier determinations to search for changes with the time. No definite evidence for such changes has been found, although there may be an indication of a change in phi Per. A re-determination of the errors involved in the method of analysis shows that these are smaller than previously estimated and range from about 9% to 35% for both envelope model and emission region radius. (Auth.)

  20. Asymmetry of the SN 1987A envelope

    International Nuclear Information System (INIS)

    Chugaj, N.N.

    1991-01-01

    The origin of the peculiar structure in the profiles of the emission lines observed in the spectrum of SN 1987A, namely, (1) redshift of maxima, and (2) fine structure of hydrogen lines, is considered. Among the three proposed hypothesis for the redshift, at least two (electron scattering in the spherically-symmetric envelope, and geometrical effects in the fragmented envelope) have serious drawbacks. More favorable is the third hypothesis which invokes asymmetric distribution of 56 Ni and of the iron-peak elements

  1. Radio Imaging of Envelopes of Evolved Stars

    Science.gov (United States)

    Cotton, Bill

    2018-04-01

    This talk will cover imaging of stellar envelopes using radio VLBI techniques; special attention will be paid to the technical differences between radio and optical/IR interferomery. Radio heterodyne receivers allow a straightforward way to derive spectral cubes and full polarization observations. Milliarcsecond resolution of very bright, i.e. non thermal, emission of molecular masers in the envelopes of evolved stars can be achieved using VLBI techniques with baselines of thousands of km. Emission from SiO, H2O and OH masers are commonly seen at increasing distance from the photosphere. The very narrow maser lines allow accurate measurements of the velocity field within the emitting region.

  2. Global Envelope Tests for Spatial Processes

    DEFF Research Database (Denmark)

    Myllymäki, Mari; Mrkvička, Tomáš; Grabarnik, Pavel

    2017-01-01

    Envelope tests are a popular tool in spatial statistics, where they are used in goodness-of-fit testing. These tests graphically compare an empirical function T(r) with its simulated counterparts from the null model. However, the type I error probability α is conventionally controlled for a fixed d......) the construction of envelopes for a deviation test. These new tests allow the a priori selection of the global α and they yield p-values. We illustrate these tests using simulated and real point pattern data....

  3. Global envelope tests for spatial processes

    DEFF Research Database (Denmark)

    Myllymäki, Mari; Mrkvička, Tomáš; Grabarnik, Pavel

    Envelope tests are a popular tool in spatial statistics, where they are used in goodness-of-fit testing. These tests graphically compare an empirical function T(r) with its simulated counterparts from the null model. However, the type I error probability α is conventionally controlled for a fixed......) the construction of envelopes for a deviation test. These new tests allow the a priori selection of the global α and they yield p-values. We illustrate these tests using simulated and real point pattern data....

  4. Baking sunflower hulls within an aluminum envelope in a common laboratory oven yields charcoal.

    Science.gov (United States)

    Arnal, Pablo Maximiliano

    2015-01-01

    Charcoals have been widely used by scientist to research the removal of contaminants from water and air. One key feature of charcoal is that it keeps macropores from the parent material - though anisotropically contracted - and can even develop meso- and micropores. However, the controlled thermochemical conversion of biomass into charcoal at laboratory scale normally requires special setups which involve either vacuum or inert gas. Those setups may not be affordable in research groups or educational institutions where the research of charcoals would be highly welcome. In this work, I propose a simple and effective method to steer the thermochemical process that converts sunflower hulls (SFH) into charcoal with basic laboratory resources. The carbonization method: •Place SFH in an airtight aluminum envelope.•Thermally treat SFH within the envelope in a common laboratory oven.•Open the envelope to obtain the carbonized sunflower hulls.

  5. Multi-objective and multidisciplinary design optimization of large sports building envelopes : A case study

    NARCIS (Netherlands)

    Yang, D.; Sun, Y.; Turrin, M.; von Buelow, P.; Paul, J.C.

    2015-01-01

    Currently, in the conceptual envelope design of sports facilities, multiple engineering performance feedbacks (e.g. daylight, energy and structural performance) are expected to assist architectural design decision-making. In general, it is known as Building Performance Optimization in the conceptual

  6. Integrated Energy Design of the Building Envelope

    DEFF Research Database (Denmark)

    Nielsen, Martin Vraa

    This thesis describes the outcome of the PhD project Integrated energy design of the building envelope carried out through a combination of scientific dissemination reported through peer-reviewed journals and a wide range of affiliated projects involved in at an architectural firm. The research...

  7. SAFEGUARDS ENVELOPE: PREVIOUS WORK AND EXAMPLES

    International Nuclear Information System (INIS)

    Metcalf, Richard; Bevill, Aaron; Charlton, William; Bean, Robert

    2008-01-01

    The future expansion of nuclear power will require not just electricity production but fuel cycle facilities such as fuel fabrication and reprocessing plants. As large reprocessing facilities are built in various states, they must be built and operated in a manner to minimize the risk of nuclear proliferation. Process monitoring has returned to the spotlight as an added measure that can increase confidence in the safeguards of special nuclear material (SNM). Process monitoring can be demonstrated to lengthen the allowable inventory period by reducing accountancy requirements, and to reduce the false positive indications. The next logical step is the creation of a Safeguards Envelope, a set of operational parameters and models to maximize anomaly detection and inventory period by process monitoring while minimizing operator impact and false positive rates. A brief example of a rudimentary Safeguards Envelope is presented, and shown to detect synthetic diversions overlaying a measured processing plant data set. This demonstration Safeguards Envelope is shown to increase the confidence that no SNM has been diverted with minimal operator impact, even though it is based on an information sparse environment. While the foundation on which a full Safeguards Envelope can be built has been presented in historical demonstrations of process monitoring, several requirements remain yet unfulfilled. Future work will require reprocessing plant transient models, inclusion of 'non-traditional' operating data, and exploration of new methods of identifying subtle events in transient processes

  8. Multi-layered breathing architectural envelope

    DEFF Research Database (Denmark)

    Lund Larsen, Andreas; Foged, Isak Worre; Jensen, Rasmus Lund

    2014-01-01

    A multi layered breathing envelope is developed as a method of natural ventilation. The two main layers consist of mineral wool and air permeable concrete. The mineral wool works as a dynamic insulation and the permeable concrete as a heat recovery system with a high thermal mass for heat storage...

  9. Cost Allocation and Convex Data Envelopment

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Tind, Jørgen

    such as Data Envelopment Analysis (DEA). The convexity constraint of the BCC model introduces a non-zero slack in the objective function of the multiplier problem and we show that the cost allocation rules discussed in this paper can be used as candidates to allocate this slack value on to the input (or output...

  10. Moisture condensation on building envelopes in differential ventilated spaces in the tropics: quantitative assessment of influencing factors

    Directory of Open Access Journals (Sweden)

    Ali Maisarah

    2016-01-01

    Full Text Available Ventilation systems play a significant role in maintaining the indoor thermal and hygric balance. Nevertheless, the systems had been implicated to result in many problems. In the tropical climate, especially for energy efficiency purposes, building spaces are operated with differential ventilation. Such spaces operate on 24-hrs basis, some on 8-hrs while others are either naturally ventilated or served with mechanical supply-exhaust fan systems with non-conditioned outdoor air. This practice had been found to result in condensation problems. This study involves a quantitative appraisal of the effect of operative conditions and hygrothermal quality of building envelopes on condensation risk. The in-situ experiment is combined with an analytical approach to assessing the hygrothermal quality of building envelopes in a tropical climate building under differential ventilation between adjacent spaces. The case-studied building is with a known history of condensation and associated damages including mould growth. The microclimate measurement and hygrothermal performance of the wall and floor against condensation and mould growth risks had been previously reported elsewhere. As a step further, the present study evaluates the effects of various envelope insulation types and configurations together with the HVAC cooling set-points on envelope hygrothermal performance. The results revealed that overcooling the air-conditioned side increases condensation risk on the non-air-conditioned side of the envelopes. The envelopes failed criteria for surface condensation at existing operative conditions irrespective of envelope hygrothermal quality improvements. However, the envelope performed well at improved cooling operative conditions even at existing envelope hygrothermal quality. It is, therefore, important to ascertain the envelope hygrothermal quality as well the cooling operative conditions while embarking on energy efficiency operations in mechanical

  11. Binaural hearing in children using Gaussian enveloped and transposed tones.

    Science.gov (United States)

    Ehlers, Erica; Kan, Alan; Winn, Matthew B; Stoelb, Corey; Litovsky, Ruth Y

    2016-04-01

    Children who use bilateral cochlear implants (BiCIs) show significantly poorer sound localization skills than their normal hearing (NH) peers. This difference has been attributed, in part, to the fact that cochlear implants (CIs) do not faithfully transmit interaural time differences (ITDs) and interaural level differences (ILDs), which are known to be important cues for sound localization. Interestingly, little is known about binaural sensitivity in NH children, in particular, with stimuli that constrain acoustic cues in a manner representative of CI processing. In order to better understand and evaluate binaural hearing in children with BiCIs, the authors first undertook a study on binaural sensitivity in NH children ages 8-10, and in adults. Experiments evaluated sound discrimination and lateralization using ITD and ILD cues, for stimuli with robust envelope cues, but poor representation of temporal fine structure. Stimuli were spondaic words, Gaussian-enveloped tone pulse trains (100 pulse-per-second), and transposed tones. Results showed that discrimination thresholds in children were adult-like (15-389 μs for ITDs and 0.5-6.0 dB for ILDs). However, lateralization based on the same binaural cues showed higher variability than seen in adults. Results are discussed in the context of factors that may be responsible for poor representation of binaural cues in bilaterally implanted children.

  12. Moisture accumulation in a building envelope

    Energy Technology Data Exchange (ETDEWEB)

    Forest, T.W.; Checkwitch, K.

    1988-09-01

    In a large number of cases, the failure of a building envelope can be traced to the accumulation of moisture. In a cold winter climate, characteristic of the Canadian prairies, moisture is deposited in the structure by the movement of warm, moist air through the envelope. Tests on the moisture accumulation in a building envelope were initiated in a test house at an Alberta research facility during the 1987/88 heating season. The indoor moisture generation rate was measured and compared with the value inferred from the measured air infiltration rate. With the flue open, the moisture generation rate was approximately 5.5 kg/d of which 0.7 kg/d entered the building envelope; the remainder was exhausted through the flue. With the flue blocked, the moisture generation rate decreased to 3.4 kg/d, while the amount of moisture migrating through the envelope increased to 4.0 kg/d. The moisture accumulation in wall panels located on the north and south face of the test house was also monitored. Moisture was allowed to enter the wall cavity via a hole in the drywall. The fiberglass insulation remained dry throughout the test period. The moisture content of the exterior sheathing of the north panel increased to a maximum of 18% wt in the vicinity of the hole, but quickly dried when the ambient temperatures increased towards the end of the season. The south panel showed very little moisture accumlation due to the effects of solar radiation. 14 refs., 9 figs.

  13. Validating predictions from climate envelope models.

    Directory of Open Access Journals (Sweden)

    James I Watling

    Full Text Available Climate envelope models are a potentially important conservation tool, but their ability to accurately forecast species' distributional shifts using independent survey data has not been fully evaluated. We created climate envelope models for 12 species of North American breeding birds previously shown to have experienced poleward range shifts. For each species, we evaluated three different approaches to climate envelope modeling that differed in the way they treated climate-induced range expansion and contraction, using random forests and maximum entropy modeling algorithms. All models were calibrated using occurrence data from 1967-1971 (t1 and evaluated using occurrence data from 1998-2002 (t2. Model sensitivity (the ability to correctly classify species presences was greater using the maximum entropy algorithm than the random forest algorithm. Although sensitivity did not differ significantly among approaches, for many species, sensitivity was maximized using a hybrid approach that assumed range expansion, but not contraction, in t2. Species for which the hybrid approach resulted in the greatest improvement in sensitivity have been reported from more land cover types than species for which there was little difference in sensitivity between hybrid and dynamic approaches, suggesting that habitat generalists may be buffered somewhat against climate-induced range contractions. Specificity (the ability to correctly classify species absences was maximized using the random forest algorithm and was lowest using the hybrid approach. Overall, our results suggest cautious optimism for the use of climate envelope models to forecast range shifts, but also underscore the importance of considering non-climate drivers of species range limits. The use of alternative climate envelope models that make different assumptions about range expansion and contraction is a new and potentially useful way to help inform our understanding of climate change effects on

  14. Validating predictions from climate envelope models

    Science.gov (United States)

    Watling, J.; Bucklin, D.; Speroterra, C.; Brandt, L.; Cabal, C.; Romañach, Stephanie S.; Mazzotti, Frank J.

    2013-01-01

    Climate envelope models are a potentially important conservation tool, but their ability to accurately forecast species’ distributional shifts using independent survey data has not been fully evaluated. We created climate envelope models for 12 species of North American breeding birds previously shown to have experienced poleward range shifts. For each species, we evaluated three different approaches to climate envelope modeling that differed in the way they treated climate-induced range expansion and contraction, using random forests and maximum entropy modeling algorithms. All models were calibrated using occurrence data from 1967–1971 (t1) and evaluated using occurrence data from 1998–2002 (t2). Model sensitivity (the ability to correctly classify species presences) was greater using the maximum entropy algorithm than the random forest algorithm. Although sensitivity did not differ significantly among approaches, for many species, sensitivity was maximized using a hybrid approach that assumed range expansion, but not contraction, in t2. Species for which the hybrid approach resulted in the greatest improvement in sensitivity have been reported from more land cover types than species for which there was little difference in sensitivity between hybrid and dynamic approaches, suggesting that habitat generalists may be buffered somewhat against climate-induced range contractions. Specificity (the ability to correctly classify species absences) was maximized using the random forest algorithm and was lowest using the hybrid approach. Overall, our results suggest cautious optimism for the use of climate envelope models to forecast range shifts, but also underscore the importance of considering non-climate drivers of species range limits. The use of alternative climate envelope models that make different assumptions about range expansion and contraction is a new and potentially useful way to help inform our understanding of climate change effects on species.

  15. Performance, fatigue and stress in open-plan offices: The effects of noise and restoration on hearing impaired and normal hearing individuals

    Directory of Open Access Journals (Sweden)

    Helena Jahncke

    2012-01-01

    Full Text Available Hearing impaired and normal hearing individuals were compared in two within-participant office noise conditions (high noise: 60 L Aeq and low noise: 30 L Aeq . Performance, subjective fatigue, and physiological stress were tested during working on a simulated open-plan office. We also tested two between-participants restoration conditions following the work period with high noise (nature movie or continued office noise. Participants with a hearing impairment (N = 20 were matched with normal hearing participants (N = 18 and undertook one practice session and two counterbalanced experimental sessions. In each experimental session they worked for two hours with basic memory and attention tasks. We also measured physiological stress indicators (cortisol and catecholamines and self-reports of mood and fatigue. The hearing impaired participants were more affected by high noise than the normal hearing participants, as shown by impaired performance for tasks that involve recall of semantic information. The hearing impaired participants were also more fatigued by high noise exposure than participants with normal hearing, and they tended to have higher stress hormone levels during the high noise compared to the low noise condition. Restoration with a movie increased performance and motivation for the normal hearing participants, while rest with continued noise did not. For the hearing impaired participants, continued noise during rest increased motivation and performance, while the movie did not. In summary, the impact of noise and restorative conditions varied with the hearing characteristics of the participants. The small sample size does however encourage caution when interpreting the results.

  16. Performance in normal subjects on a novel battery of driving-related sensory-motor and cognitive tests.

    Science.gov (United States)

    Innes, Carrie R H; Jones, Richard D; Anderson, Tim J; Hollobon, Susan G; Dalrymple-Alford, John C

    2009-05-01

    Currently, there is no international standard for the assessment of fitness to drive for cognitively or physically impaired persons. A computerized battery of driving-related sensory-motor and cognitive tests (SMCTests) has been developed, comprising tests of visuoperception, visuomotor ability, complex attention, visual search, decision making, impulse control, planning, and divided attention. Construct validity analysis was conducted in 60 normal, healthy subjects and showed that, overall, the novel cognitive tests assessed cognitive functions similar to a set of standard neuropsychological tests. The novel tests were found to have greater perceived face validity for predicting on-road driving ability than was found in the equivalent standard tests. Test-retest stability and reliability of SMCTests measures, as well as correlations between SMCTests and on-road driving, were determined in a subset of 12 subjects. The majority of test measures were stable and reliable across two sessions, and significant correlations were found between on-road driving scores and measures from ballistic movement, footbrake reaction, hand-control reaction, and complex attention. The substantial face validity, construct validity, stability, and reliability of SMCTests, together with the battery's level of correlation with on-road driving in normal subjects, strengthen our confidence in the ability of SMCTests to detect and identify sensory-motor and cognitive deficits related to unsafe driving and increased risk of accidents.

  17. Mass-radius relations and core-envelope decompositions of super-Earths and sub-Neptunes

    International Nuclear Information System (INIS)

    Howe, Alex R.; Burrows, Adam; Verne, Wesley

    2014-01-01

    Many exoplanets have been discovered with radii of 1-4 R ⊕ , between that of Earth and Neptune. A number of these are known to have densities consistent with solid compositions, while others are 'sub-Neptunes' likely to have significant H 2 -He envelopes. Future surveys will no doubt significantly expand these populations. In order to understand how the measured masses and radii of such planets can inform their structures and compositions, we construct models both for solid layered planets and for planets with solid cores and gaseous envelopes, exploring a range of core masses, H 2 -He envelope masses, and associated envelope entropies. For planets in the super-Earth/sub-Neptune regime for which both radius and mass are measured, we estimate how each is partitioned into a solid core and gaseous envelope, associating a specific core mass and envelope mass with a given exoplanet. We perform this decomposition for both ''Earth-like'' rock-iron cores and pure ice cores, and find that the necessary gaseous envelope masses for this important sub-class of exoplanets must range very widely from zero to many Earth masses, even for a given core mass. This result bears importantly on exoplanet formation and envelope evaporation processes.

  18. Mass-radius relations and core-envelope decompositions of super-Earths and sub-Neptunes

    Energy Technology Data Exchange (ETDEWEB)

    Howe, Alex R.; Burrows, Adam [Department of Astrophysical Sciences, Princeton University, Peyton Hall, Princeton, NJ 08544 (United States); Verne, Wesley, E-mail: arhowe@astro.princeton.edu, E-mail: burrows@astro.princeton.edu [Department of Computer Science, Princeton University, Princeton, NJ 08544 (United States)

    2014-06-01

    Many exoplanets have been discovered with radii of 1-4 R {sub ⊕}, between that of Earth and Neptune. A number of these are known to have densities consistent with solid compositions, while others are 'sub-Neptunes' likely to have significant H{sub 2}-He envelopes. Future surveys will no doubt significantly expand these populations. In order to understand how the measured masses and radii of such planets can inform their structures and compositions, we construct models both for solid layered planets and for planets with solid cores and gaseous envelopes, exploring a range of core masses, H{sub 2}-He envelope masses, and associated envelope entropies. For planets in the super-Earth/sub-Neptune regime for which both radius and mass are measured, we estimate how each is partitioned into a solid core and gaseous envelope, associating a specific core mass and envelope mass with a given exoplanet. We perform this decomposition for both ''Earth-like'' rock-iron cores and pure ice cores, and find that the necessary gaseous envelope masses for this important sub-class of exoplanets must range very widely from zero to many Earth masses, even for a given core mass. This result bears importantly on exoplanet formation and envelope evaporation processes.

  19. Assessing Canadian Bank Branch Operating Efficiency Using Data Envelopment Analysis

    Science.gov (United States)

    Yang, Zijiang

    2009-10-01

    In today's economy and society, performance analyses in the services industries attract more and more attention. This paper presents an evaluation of 240 branches of one big Canadian bank in Greater Toronto Area using Data Envelopment Analysis (DEA). Special emphasis was placed on how to present the DEA results to management so as to provide more guidance to them on what to manage and how to accomplish the changes. Finally the potential management uses of the DEA results were presented. All the findings are discussed in the context of the Canadian banking market.

  20. Novel Real-Time Flight Envelope Monitoring System, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed innovation is an aircraft flight envelope monitoring system that will provide real-time in-cockpit estimations of aircraft flight envelope boundaries....

  1. Clarifying Normalization

    Science.gov (United States)

    Carpenter, Donald A.

    2008-01-01

    Confusion exists among database textbooks as to the goal of normalization as well as to which normal form a designer should aspire. This article discusses such discrepancies with the intention of simplifying normalization for both teacher and student. This author's industry and classroom experiences indicate such simplification yields quicker…

  2. The Myocardial Performance Index During Low Dose Dobutamine Echocardiography in Normals and Patients With a Recent Myocardial Infarction

    DEFF Research Database (Denmark)

    Nørager, Betina; Husic, Mirza; Møller, Jacob E

    2004-01-01

    BACKGROUND: Wall-motion analysis during low-dose dobutamine echocardiography (LDDE) is a semiquantitative measure of left ventricular contractile reserve after myocardial infarction (MI). The Doppler echocardiographic myocardial performance index (MPI) is a quantitative measure of combined left...

  3. Energy Optimized Envelope for Cold Climate Indoor Agricultural Growing Center

    Directory of Open Access Journals (Sweden)

    Caroline Hachem-Vermette

    2017-07-01

    Full Text Available This paper presents a study of the development of building envelope design for improved energy performance of a controlled indoor agricultural growing center in a cold climate zone (Canada, 54° N. A parametric study is applied to analyze the effects of envelope parameters on the building energy loads for heating, cooling and lighting, required for maintaining growing requirement as obtained in the literature. A base case building of rectangular layout, incorporating conventionally applied insulation and glazing components, is initially analyzed, employing the EnergyPlus simulation program. Insulation and glazing parameters are then modified to minimize energy loads under assumed minimal lighting requirement. This enhanced design forms a base case for analyzing effects of additional design parameters—solar radiation control, air infiltration rate, sky-lighting and the addition of phase change materials—to obtain an enhanced design that minimizes energy loads. A second stage of the investigation applies a high lighting level to the enhanced design and modifies the design parameters to improve performance. A final part of the study is an investigation of the mechanical systems and renewable energy generation. Through the enhancement of building envelope components and day-lighting design, combined heating and cooling load of the low level lighting configuration is reduced by 65% and lighting load by 10%, relative to the base case design. Employing building integrated PV (BIPV system, this optimized model can achieve energy positive status. Solid Oxide Fuel Cells (SOFC, are discussed, as potential means to offset increased energy consumption associated with the high-level lighting model.

  4. Inversion of Auditory Spectrograms, Traditional Spectrograms, and Other Envelope Representations

    DEFF Research Database (Denmark)

    Decorsière, Remi Julien Blaise; Søndergaard, Peter Lempel; MacDonald, Ewen

    2015-01-01

    Envelope representations such as the auditory or traditional spectrogram can be defined by the set of envelopes from the outputs of a filterbank. Common envelope extraction methods discard information regarding the fast fluctuations, or phase, of the signal. Thus, it is difficult to invert, or re...... to the framework is proposed, which leads to a more accurate inversion of traditional spectrograms...

  5. 200 Area Deactivation Project Facilities Authorization Envelope Document

    International Nuclear Information System (INIS)

    DODD, E.N.

    2000-01-01

    Project facilities as required by HNF-PRO-2701, Authorization Envelope and Authorization Agreement. The Authorization Agreements (AA's) do not identify the specific set of environmental safety and health requirements that are applicable to the facility. Therefore, the facility Authorization Envelopes are defined here to identify the applicable requirements. This document identifies the authorization envelopes for the 200 Area Deactivation

  6. Analysis of Building Envelope Construction in 2003 CBECS

    Energy Technology Data Exchange (ETDEWEB)

    Winiarski, David W.; Halverson, Mark A.; Jiang, Wei

    2007-06-01

    The purpose of this analysis is to determine "typical" building envelope characteristics for buildings built after 1980. We address three envelope components in this paper - roofs, walls, and window area. These typical building envelope characteristics were used in the development of DOE’s Reference Buildings .

  7. A two stage data envelopment analysis model with undesirable output

    Science.gov (United States)

    Shariff Adli Aminuddin, Adam; Izzati Jaini, Nur; Mat Kasim, Maznah; Nawawi, Mohd Kamal Mohd

    2017-09-01

    The dependent relationship among the decision making units (DMU) is usually assumed to be non-existent in the development of Data Envelopment Analysis (DEA) model. The dependency can be represented by the multi-stage DEA model, where the outputs from the precedent stage will be the inputs for the latter stage. The multi-stage DEA model evaluate both the efficiency score for each stages and the overall efficiency of the whole process. The existing multi stage DEA models do not focus on the integration with the undesirable output, in which the higher input will generate lower output unlike the normal desirable output. This research attempts to address the inclusion of such undesirable output and investigate the theoretical implication and potential application towards the development of multi-stage DEA model.

  8. Infrared spectrophotometry and radiative transfer in optically thick circumstellar dust envelopes

    International Nuclear Information System (INIS)

    Merrill, K.M.

    1976-01-01

    The Two-Micron Sky Survey of Neugebauer and Leighton and, more recently, the AFCRL Infrared Sky Survey of Walker and Price have detected numerous compact, isolated, bright infrared sources which are not identified with previously cataloged stars. Observations of many such objects suggest that extensive circumstellar dust envelopes modify the flux from a central source. The present investigations employ broad bandpass photometry at lambda lambda 1.65 μm to 12.5 μm and narrow bandpass spectrophotometry (Δ lambda/lambda approximately 0.015) at lambda lambda 2-4 μm and lambda lambda 8-13 μm to determine the properties of a large sample of such infrared sources. Infrared spectrophotometry can clearly differentiate between normal stars of spectral types M(''oxygen-rich'') and C (''carbon-rich'') on the basis of characteristic absorption bands arising in cool stellar atmospheres. Most of the 2 μ Sky Survey and many of the AFCRL Sky Survey sources appear to be stars of spectral types M and C which are differentiated from normal cool comparison stars only by the presence of extensive circumstellar dust envelopes. Due to the large optical depth of the envelopes, the flux from the star and from the dust cannot be simply separated. Hence solutions of radiative transfer through spherically symmetric envelopes of arbitrary optical depth were generated by a generalized computer code which employed opacities of real dust

  9. Magnified Neural Envelope Coding Predicts Deficits in Speech Perception in Noise.

    Science.gov (United States)

    Millman, Rebecca E; Mattys, Sven L; Gouws, André D; Prendergast, Garreth

    2017-08-09

    Verbal communication in noisy backgrounds is challenging. Understanding speech in background noise that fluctuates in intensity over time is particularly difficult for hearing-impaired listeners with a sensorineural hearing loss (SNHL). The reduction in fast-acting cochlear compression associated with SNHL exaggerates the perceived fluctuations in intensity in amplitude-modulated sounds. SNHL-induced changes in the coding of amplitude-modulated sounds may have a detrimental effect on the ability of SNHL listeners to understand speech in the presence of modulated background noise. To date, direct evidence for a link between magnified envelope coding and deficits in speech identification in modulated noise has been absent. Here, magnetoencephalography was used to quantify the effects of SNHL on phase locking to the temporal envelope of modulated noise (envelope coding) in human auditory cortex. Our results show that SNHL enhances the amplitude of envelope coding in posteromedial auditory cortex, whereas it enhances the fidelity of envelope coding in posteromedial and posterolateral auditory cortex. This dissociation was more evident in the right hemisphere, demonstrating functional lateralization in enhanced envelope coding in SNHL listeners. However, enhanced envelope coding was not perceptually beneficial. Our results also show that both hearing thresholds and, to a lesser extent, magnified cortical envelope coding in left posteromedial auditory cortex predict speech identification in modulated background noise. We propose a framework in which magnified envelope coding in posteromedial auditory cortex disrupts the segregation of speech from background noise, leading to deficits in speech perception in modulated background noise. SIGNIFICANCE STATEMENT People with hearing loss struggle to follow conversations in noisy environments. Background noise that fluctuates in intensity over time poses a particular challenge. Using magnetoencephalography, we demonstrate

  10. Separation of amino acids and antibiotics by narrow-bore and normal-bore high-performance liquid chromatography with pre-column derivatization.

    Science.gov (United States)

    Fiedler, H P; Plaga, A

    1987-01-16

    The selectivity, efficiency and lifetime of normal- and narrow-bore columns for high-performance liquid chromatography were investigated for the separation and quantification of amino acids and the amino acid-like antibiotics phosphinothricin and phosphinothricylalanylalanine in biological samples. These compounds were determined by an automated pre-column derivatization with o-phthalaldehyde-2-mercaptoethanol reagent and UV detection at 338 nm.

  11. 78 FR 6195 - Special Conditions: Embraer S.A., Model EMB-550 Airplanes; Flight Envelope Protection...

    Science.gov (United States)

    2013-01-30

    ... Envelope Protection: Performance Credit for Automatic Takeoff Thrust Control System (ATTCS) During Go... a result, if an engine failure occurs during a go-around, the remaining engine automatically applies... to limit the adverse performance effects of a combined engine and ATTCS failure, and ensures adequate...

  12. 77 FR 67309 - Special Conditions: Embraer S.A., Model EMB-550 Airplanes; Flight Envelope Protection...

    Science.gov (United States)

    2012-11-09

    ... Envelope Protection: Performance Credit for Automatic Takeoff Thrust Control System (ATTCS) During Go... a result, if an engine failure occurs during a go-around, the remaining engine automatically applies... serves to limit the adverse performance effects of a combined engine and ATTCS failure, and ensures...

  13. High "normal" blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the PATH through life study.

    Directory of Open Access Journals (Sweden)

    Moyra E Mortby

    Full Text Available Type 2 diabetes is associated with cerebral atrophy, cognitive impairment and dementia. We recently showed higher glucose levels in the normal range not to be free of adverse effects and to be associated with greater hippocampal and amygdalar atrophy in older community-dwelling individuals free of diabetes.This study aimed to determine whether blood glucose levels in the normal range (<6.1 mmol/L were associated with cerebral volumes in structures other than the hippocampus and amygdale, and whether these glucose-related regional volumes were associated with cognitive performance.210 cognitively healthy individuals (68-73 years without diabetes, glucose intolerance or metabolic syndrome were assessed in the large, community-based Personality and Total Health Through Life (PATH study.Baseline blood glucose levels in the normal range (3.2-6.1 mmol/l were used to determine regional brain volumes and associated cognitive function at wave 3.Higher blood glucose levels in the normal range were associated with lower grey/white matter regional volumes in the frontal cortices (middle frontal gyrus, inferior frontal gyrus precentral gyrus. Moreover, identified cerebral regions were associated with poorer cognitive performance and the structure-function associations were gender specific to men.These findings stress the need to re-evaluate what is considered as healthy blood glucose levels, and consider the role of higher normal blood glucose as a risk factor for cerebral health, cognitive function and dementia. A better lifetime management of blood glucose levels may contribute to improved cerebral and cognitive health in later life and possibly protect against dementia.

  14. Equivariant calculus in the differential envelope

    International Nuclear Information System (INIS)

    Kastler, D.

    1991-01-01

    The author shows how Z/2-graded cyclic cohomology is related to the equivariant calculus of S. Klimek, W. Kondracki, and A. Lesniewski (HUTMP 90/B247 (1990)). He uses the differential envelope of a complex unital differential algebra. After a presentation of fiber-preserved operators on equivariant functions valued in this algebra on a group he considers certain operators on this algebra. Finally he discusses explicitly the case G=Z/2. (HSI)

  15. Equivariant calculus in the differential envelope

    Energy Technology Data Exchange (ETDEWEB)

    Kastler, D. (Centre National de la Recherche Scientifique, 13 - Marseille (France). Centre de Physique Theorique)

    1991-01-01

    The author shows how Z/2-graded cyclic cohomology is related to the equivariant calculus of S. Klimek, W. Kondracki, and A. Lesniewski (HUTMP 90/B247 (1990)). He uses the differential envelope of a complex unital differential algebra. After a presentation of fiber-preserved operators on equivariant functions valued in this algebra on a group he considers certain operators on this algebra. Finally he discusses explicitly the case G=Z/2. (HSI).

  16. HIFISTARS Herschel/HIFI observations of VY Canis Majoris. Molecular-line inventory of the envelope around the largest known star

    Science.gov (United States)

    Alcolea, J.; Bujarrabal, V.; Planesas, P.; Teyssier, D.; Cernicharo, J.; De Beck, E.; Decin, L.; Dominik, C.; Justtanont, K.; de Koter, A.; Marston, A. P.; Melnick, G.; Menten, K. M.; Neufeld, D. A.; Olofsson, H.; Schmidt, M.; Schöier, F. L.; Szczerba, R.; Waters, L. B. F. M.

    2013-11-01

    Aims: The study of the molecular gas in the circumstellar envelopes of evolved stars is normally undertaken by observing lines of CO (and other species) in the millimetre-wave domain. In general, the excitation requirements of the observed lines are low at these wavelengths, and therefore these observations predominantly probe the cold outer envelope while studying the warm inner regions of the envelopes normally requires sub-millimetre (sub-mm) and far-infrared (FIR) observational data. Methods: To gain insight into the physical conditions and kinematics of the warm (100-1000 K) gas around the red hyper-giant VY CMa, we performed sensitive high spectral resolution observations of molecular lines in the sub-mm/FIR using the HIFI instrument of the Herschel Space Observatory. We observed CO, H2O, and other molecular species, sampling excitation energies from a few tens to a few thousand K. These observations are part of the Herschel guaranteed time key program HIFISTARS. Results: We detected the J = 6-5, J = 10-9, and J = 16-15 lines of 12CO and 13CO at ~100, 300, and 750 K above the ground state (and the 13CO J = 9-8 line). These lines are crucial for improving the modelling of the internal layers of the envelope around VY CMa. We also detected 27 lines of H2O and its isotopomers, and 96 lines of species such as NH3, SiO, SO, SO2 HCN, OH and others, some of them originating from vibrationally excited levels. Three lines were not unambiguously assigned. Conclusions: Our observations confirm that VY CMa's envelope must consist of two or more detached components. The molecular excitation in the outer layers is significantly lower than in the inner ones, resulting in strong self-absorbed profiles in molecular lines that are optically thick in this outer envelope, for instance, low-lying lines of H2O. Except for the most abundant species, CO and H2O, most of the molecular emission detected at these sub-mm/FIR wavelengths arise from the central parts of the envelope. The

  17. The cell envelope glycoconjugates of Mycobacterium tuberculosis

    Science.gov (United States)

    Angala, Shiva Kumar; Belardinelli, Juan Manuel; Huc-Claustre, Emilie; Wheat, William H.; Jackson, Mary

    2015-01-01

    Tuberculosis (TB) remains the second most common cause of death due to a single infectious agent. The cell envelope of Mycobacterium tuberculosis (Mtb), the causative agent of the disease in humans, is a source of unique glycoconjugates and the most distinctive feature of the biology of this organism. It is the basis of much of Mtb pathogenesis and one of the major causes of its intrinsic resistance to chemotherapeutic agents. At the same time, the unique structures of Mtb cell envelope glycoconjugates, their antigenicity and essentiality for mycobacterial growth provide opportunities for drug, vaccine, diagnostic and biomarker development, as clearly illustrated by recent advances in all of these translational aspects. This review focuses on our current understanding of the structure and biogenesis of Mtb glycoconjugates with particular emphasis on one of most intriguing and least understood aspect of the physiology of mycobacteria: the translocation of these complex macromolecules across the different layers of the cell envelope. It further reviews the rather impressive progress made in the last ten years in the discovery and development of novel inhibitors targeting their biogenesis. PMID:24915502

  18. Spectral envelope sensitivity of musical instrument sounds.

    Science.gov (United States)

    Gunawan, David; Sen, D

    2008-01-01

    It is well known that the spectral envelope is a perceptually salient attribute in musical instrument timbre perception. While a number of studies have explored discrimination thresholds for changes to the spectral envelope, the question of how sensitivity varies as a function of center frequency and bandwidth for musical instruments has yet to be addressed. In this paper a two-alternative forced-choice experiment was conducted to observe perceptual sensitivity to modifications made on trumpet, clarinet and viola sounds. The experiment involved attenuating 14 frequency bands for each instrument in order to determine discrimination thresholds as a function of center frequency and bandwidth. The results indicate that perceptual sensitivity is governed by the first few harmonics and sensitivity does not improve when extending the bandwidth any higher. However, sensitivity was found to decrease if changes were made only to the higher frequencies and continued to decrease as the distorted bandwidth was widened. The results are analyzed and discussed with respect to two other spectral envelope discrimination studies in the literature as well as what is predicted from a psychoacoustic model.

  19. Use of computerized tests to evaluate psychomotor performance in children with specific learning disabilities in comparison to normal children

    Directory of Open Access Journals (Sweden)

    Santosh Taur

    2014-01-01

    Full Text Available Background & objectives: Children with specific learning disabilities (SpLD have an unexplained difficulty in acquiring basic academic skills resulting in a significant discrepancy between their academic potential and achievements. This study was undertaken to compare the performance on a battery of six psychomotor tests of children with SpLD and those without any learning disabilities (controls using computerized tests. Methods: In this study, 25 children with SpLD and 25 controls (matched for age, socio-economic status and medium of instruction were given three training sessions over one week. Then children were asked to perform on the six computerized psychomotor tests. Results were compared between the two groups. Results: Children with SpLD fared significantly worse on finger tapping test, choice reaction test, digit picture substitution test and card sorting test compared to the controls ( p <0.05. Interpretation & conclusions: Children with SpLD have impairment of psychomotor skills like attention, sensory-motor coordination and executive functioning. Further research is needed to evaluate if the remedial education plan results in improvement in psychomotor performance of children with SpLD on these selected tests.

  20. Integrated energy design of the building envelope

    Energy Technology Data Exchange (ETDEWEB)

    Vraa Nielsen, M.

    2012-07-01

    This thesis describes the outcome of the PhD project Integrated energy design of the building envelope carried out through a combination of scientific dissemination reported through peer-reviewed journals and a wide range of affiliated projects involved in at an architectural firm. The research project analysed how the implementation of technical knowledge early in the building design process can quantify the effect of a building's facades on its energy efficiency and indoor climate and thereby facilitate a more qualified design development. The project was structured in the following way: 1) the importance of integrating knowledge in the early stages of design, and how it can be done; 2) understanding the facade's typology; and 3) the complex notion of comfort. The project touched not only on the technical capabilities and requirements governing facade design, but also the process by which it takes place. This was done by applying the methodology of Integrated Energy Design (IED) and analysing its applicability in the design of facades. A major part of the project was an actual engagement in the architectural process to test out incorporating a consciousness about energy and comfort as part of a more holistic performance evaluation. The research project illustrates the great potential in taking passive properties into account through a geometrical optimisation inherent in the development of the architectural concept. It demonstrates that integration of technical knowledge at the early stages of design not only can qualify the geometrical processing, but also facilitate the design development of the facade. Thereby a more holistic performance optimisation can be obtained through parameters such as overall facade geometry and orientation, functional organisation, room height and depth, facade layout, window geometry and transparency, design of the window aperture, etc. Through the wide range of affiliated project involved in at the architectural firm over

  1. Reuse and Upcycling of Municipal Waste for ZEB Envelope Design in European Urban Areas

    Directory of Open Access Journals (Sweden)

    Elisa Pennacchia

    2016-06-01

    Full Text Available Building energy efficiency and urban waste management are two focal issues for improving environmental status and reducing greenhouse gas emissions. The main aim of this paper is to compare economic costs of new building envelope structures designed by authors reusing and upcycling municipal waste in order to decrease energy demand from the building sector and, at the same time, improve eco-friendly waste management at the local scale. The reuse of waste for building envelope structures is one of the main principles of the Earthship buildings model, based on the use of passive solar principles in autonomous earth-sheltered homes. This Earthship principle has been analyzed in order to optimize buildings’ energy performance and reuse municipal waste for new building envelope structures in urban areas. Indeed, the elaborated structures have been designed for urban contexts, with the aim of reuse waste coming from surrounding landfills. The methods include an analysis of thermal performance of urban waste for designing new building envelope structures realized by assembling waste and isolating materials not foreseen in Earthship buildings. The reused materials are: cardboard tubes, automobile tires, wood pallets, and plastic and glass bottles. Finally, comparing economic costs of these new building envelope structures, the obtained results highlight their economic feasibility compared to a traditional structure with similar thermal transmittance.

  2. Advanced Envelope Research for Factory Built Housing, Phase 3 -- Design Development and Prototyping

    Energy Technology Data Exchange (ETDEWEB)

    Levy, E. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kessler, B. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Mullens, M. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Rath, P. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2014-01-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective alternative envelope designs. In the near term, these technologies will play a central role in meeting stringent energy code requirements. For manufactured homes, the thermal requirements, last updated by statute in 1994, will move up to the more rigorous IECC 2012 levels in 2013, the requirements of which are consistent with site built and modular housing. This places added urgency on identifying envelope technologies that the industry can implement in the short timeframe. The primary goal of this research is to develop wall designs that meet the thermal requirements based on 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing the new envelope technologies. This work is part of a four-phase, multi-year effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three selected methods for building high performance wall systems. Phase 2 focused on the development of viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped critique and select the most viable solution to move further in the research -- stud walls with continuous exterior insulation. Phase 3, the subject of the current report, focused on the design development of the selected wall concept and explored variations on the use of exterior foam insulation. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing.

  3. Advanced Envelope Research for Factory Built Housing, Phase 3. Design Development and Prototyping

    Energy Technology Data Exchange (ETDEWEB)

    Levy, E. [ARIES Collaborative, New York, NY (United States); Kessler, B. [ARIES Collaborative, New York, NY (United States); Mullens, M. [ARIES Collaborative, New York, NY (United States); Rath, P. [ARIES Collaborative, New York, NY (United States)

    2014-01-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective alternative envelope designs. In the near term, these technologies will play a central role in meeting stringent energy code requirements. For manufactured homes, the thermal requirements, last updated by statute in 1994, will move up to the more rigorous IECC 2012 levels in 2013, the requirements of which are consistent with site built and modular housing. This places added urgency on identifying envelope technologies that the industry can implement in the short timeframe. The primary goal of this research is to develop wall designs that meet the thermal requirements based on 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing the new envelope technologies. This work is part of a four-phase, multi-year effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three selected methods for building high performance wall systems. Phase 2 focused on the development of viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped critique and select the most viable solution to move further in the research -- stud walls with continuous exterior insulation. Phase 3, the subject of the current report, focused on the design development of the selected wall concept and explored variations on the use of exterior foam insulation. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing.

  4. Dynamic network data envelopment analysis for university hospitals evaluation

    Directory of Open Access Journals (Sweden)

    Maria Stella de Castro Lobo

    2016-01-01

    Full Text Available ABSTRACT OBJECTIVE To develop an assessment tool to evaluate the efficiency of federal university general hospitals. METHODS Data envelopment analysis, a linear programming technique, creates a best practice frontier by comparing observed production given the amount of resources used. The model is output-oriented and considers variable returns to scale. Network data envelopment analysis considers link variables belonging to more than one dimension (in the model, medical residents, adjusted admissions, and research projects. Dynamic network data envelopment analysis uses carry-over variables (in the model, financing budget to analyze frontier shift in subsequent years. Data were gathered from the information system of the Brazilian Ministry of Education (MEC, 2010-2013. RESULTS The mean scores for health care, teaching and research over the period were 58.0%, 86.0%, and 61.0%, respectively. In 2012, the best performance year, for all units to reach the frontier it would be necessary to have a mean increase of 65.0% in outpatient visits; 34.0% in admissions; 12.0% in undergraduate students; 13.0% in multi-professional residents; 48.0% in graduate students; 7.0% in research projects; besides a decrease of 9.0% in medical residents. In the same year, an increase of 0.9% in financing budget would be necessary to improve the care output frontier. In the dynamic evaluation, there was progress in teaching efficiency, oscillation in medical care and no variation in research. CONCLUSIONS The proposed model generates public health planning and programming parameters by estimating efficiency scores and making projections to reach the best practice frontier.

  5. Analysis of drug-protein binding using on-line immunoextraction and high-performance affinity microcolumns: Studies with normal and glycated human serum albumin.

    Science.gov (United States)

    Matsuda, Ryan; Jobe, Donald; Beyersdorf, Jared; Hage, David S

    2015-10-16

    A method combining on-line immunoextraction microcolumns with high-performance affinity chromatography (HPAC) was developed and tested for use in examining drug-protein interactions with normal or modified proteins. Normal human serum albumin (HSA) and glycated HSA were used as model proteins for this work. High-performance immunoextraction microcolumns with sizes of 1.0-2.0 cm × 2.1mm i.d. and containing anti-HSA polyclonal antibodies were developed and tested for their ability to bind normal HSA or glycated HSA. These microcolumns were able to extract up to 82-93% for either type of protein at 0.05-0.10 mL/min and had a binding capacity of 0.34-0.42 nmol HSA for a 1.0 cm × 2.1mm i.d. microcolumn. The immunoextraction microcolumns and their adsorbed proteins were tested for use in various approaches for drug binding studies. Frontal analysis was used with the adsorbed HSA/glycated HSA to measure the overall affinities of these proteins for the drugs warfarin and gliclazide, giving comparable values to those obtained previously using similar protein preparations that had been covalently immobilized within HPAC columns. Zonal elution competition studies with gliclazide were next performed to examine the specific interactions of this drug at Sudlow sites I and II of the adsorbed proteins. These results were also comparable to those noted in prior work with covalently immobilized samples of normal HSA or glycated HSA. These experiments indicated that drug-protein binding studies can be carried out by using on-line immunoextraction microcolumns with HPAC. The same method could be used in the future with clinical samples and other drugs or proteins of interest in pharmaceutical studies or biomedical research. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Cessna Citation X Business Aircraft Eigenvalue Stability – Part2: Flight Envelope Analysis

    Directory of Open Access Journals (Sweden)

    Yamina BOUGHARI

    2017-12-01

    Full Text Available Civil aircraft flight control clearance is a time consuming, thus an expensive process in the aerospace industry. This process has to be investigated and proved to be safe for thousands of combinations in terms of speeds, altitudes, gross weights, Xcg / weight configurations and angles of attack. Even in this case, a worst-case condition that could lead to a critical situation might be missed. To address this problem, models that are able to describe an aircraft’s dynamics by taking into account all uncertainties over a region within a flight envelope have been developed using Linear Fractional Representation. In order to investigate the Cessna Citation X aircraft Eigenvalue Stability envelope, the Linear Fractional Representation models are implemented using the speeds and the altitudes as varying parameters. In this paper Part 2, the aircraft longitudinal eigenvalue stability is analyzed in a continuous range of flight envelope with varying parameter of True airspeed and altitude, instead of a single point, like classical methods. This is known as the aeroelastic stability envelope, required for civil aircraft certification as given by the Circular Advisory “Aeroelastic Stability Substantiation of Transport Category Airplanes AC No: 25.629-18”. In this new methodology the analysis is performed in time domain based on Lyapunov stability and solved by convex optimization algorithms by using the linear matrix inequalities to evaluate the eigenvalue stability, which is reduced to search for the negative eigenvalues in a region of flight envelope. It can also be used to study the stability of a system during an arbitrary motion from one point to another in the flight envelope. A whole aircraft analysis results’ for its entire envelope are presented in the form of graphs, thus offering good readability, and making them easily exploitable.

  7. An additional simple denitrification bioreactor using packed gel envelopes applicable to industrial wastewater treatment.

    Science.gov (United States)

    Morita, Masahiko; Uemoto, Hiroaki; Watanabe, Atsushi

    2007-08-15

    A simple denitrification bioreactor for nitrate-containing wastewater without organic compounds was developed. This bioreactor consisted of packed gel envelopes in a single tank. Each envelope comprised two plates of gels containing Paracoccus denitrificans cells with an internal space between the plates. As an electron donor for denitrification, ethanol was injected into the internal space and not directly into the wastewater. P. denitrificans cells in the gel reduced nitrate to nitrogen gas by using the injected ethanol. Nitrate-containing desulfurization wastewater derived from a coal-fired thermal power plant was continuously treated with 20 packed gel envelopes (size, 1,000 x 900 x 12 mm; surface area, 1.44 m(2)) in a reactor tank (volume 1.5 m(3)). When the total nitrogen concentration in the inflow was around 150 mg-N x L(-1), the envelopes removed approximately 60-80% of the total nitrogen, and the maximum nitrogen removal rate was 5.0 g-N x day(-1) per square meter of the gel surface. This value corresponded to the volumetric nitrogen removal performance of 0.109 kg-N x m(-3) x day(-1). In each envelope, a high utilization efficiency of the electron donor was attained, although more than the double amount of the electron donor was empirically injected in the present activated sludge system to achieve denitrification when compared with the theoretical value. The bioreactor using the envelopes would be extremely effective as an additional denitrification system because these envelopes can be easily installed in the vacant spaces of preinstalled water treatment systems, without requiring additional facilities for removing surplus ethanol and sludge. (c) 2007 Wiley Periodicals, Inc.

  8. Maintaining Aura's Orbit Requirements While Performing Orbit Maintenance Maneuvers Containing an Orbit Normal Delta-V Component

    Science.gov (United States)

    Johnson, Megan R.; Petersen, Jeremy D.

    2014-01-01

    The Earth Observing System (EOS) Afternoon Constellation consists of five member missions (GCOM-W1, Aqua, CALIPSO, CloudSat, and Aura), each of which maintain a frozen, sun-synchronous orbit with a 16-day repeating ground track that follows the Worldwide Reference System-2 (WRS-2). Under nominal science operations for Aura, the propulsion system is oriented such that the resultant thrust vector is aligned 13.493 degrees away from the velocity vector along the yaw axis. When performing orbit maintenance maneuvers, the spacecraft performs a yaw slew to align the thrust vector in the appropriate direction. A new Drag Make Up (DMU) maneuver operations scheme has been implemented for Aura alleviating the need for the 13.493 degree yaw slew. The focus of this investigation is to assess the impact that no-slew DMU maneuver operations will have on Aura's Mean Local Time (MLT) which drives the required along track separation between Aura and the constellation members, as well as Aura's frozen orbit properties, eccentricity and argument of perigee. Seven maneuver strategies were analyzed to determine the best operational approach. A mirror pole strategy, with maneuvers alternating at the North and South poles, was implemented operationally to minimize impact to the MLT. Additional analysis determined that the mirror pole strategy could be further modified to include frozen orbit maneuvers and thus maintain both MLT and the frozen orbit properties under noslew operations.

  9. A thermal-optical analysis comparison between symmetric tubular absorber compound parabolic concentrating solar collector with and without envelope

    International Nuclear Information System (INIS)

    Tchinda, R.

    2005-11-01

    Equations describing the heat transfer in symmetric, compound parabolic concentrating solar collectors (CPCs) with and without envelope have been established. The model takes into account the non linear behavior of these two systems. A theoretical numerical model has been developed to outline the effect of the envelope on the thermal and optical performance of CPCs. The effects of the flow rate, the plate length, the selective coating, etc. are studied. The over-all thermal loss coefficient and the enclosure absorption factor for both types are defined. It is found that the efficient configuration has an envelope. Theoretical computed values are in good agreement with the experimental values published in the literature. (author)

  10. Analysis of the documents about the core envelopment of nuclear reactor at the Laguna Verde U-1 power plant

    International Nuclear Information System (INIS)

    Zamora R, L.; Medina F, A.

    1999-01-01

    The degradation of internal components at BWR type reactors is an important subject to consider in the performance availability of the power plant. The Wuergassen nuclear reactor license was confiscated due to the presence of cracking in the core envelopment. In consequence it is necessary carrying out a detailed study with the purpose to avoid these problems in the future. This report presents a review and analysis of documents and technical information referring to the core envelopment of a BWR/5/6 and the Laguna Verde Unit 1 nuclear reactor in Mexico. In this document are presented design data, documents about fabrication processes, and manufacturing of core envelopment. (Author)

  11. CISBAT 2007 - Design and renovation of building envelopes (bioclimatic architecture)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This is the second part of the proceedings of the 2007 CISBAT conference on Renewables in a changing climate, held in Lausanne, Switzerland. On the subject of sustainable building envelopes the following oral contributions are summarised: 'Flexible photovoltaics integrated in transparent membrane and pneumatic foil constructions', 'Development of a numerical thermal model for double skin facades', 'Thermal performance analysis for an electrochromic vacuum glazing with low emittance coatings', 'Challenging the public building sector: optimization of energy performance by sustainable strategies', 'Simulation of the thermal performance of a climate adaptive skin', 'Possibilities for upgrading prefabricated concrete building envelopes', 'Experimental study of airflow and heat transfer in a double skin facade with blinds', 'Energy efficiency of a glazing system - Case study: a dynamic glazing and double skin facades - the use of venetian blinds and night ventilation for saving energy on mediterranean climate'. Poster-sessions on the subject include 'Adaptive building envelopes design ', 'GRC facade panels in Brazil', 'Solar absorptance of building opaque surfaces', 'Evaluating the thermal behavior of exterior walls (in residential buildings of hot-dry climate of Yazd)', 'Energy performance of buildings and local energy policy: the case of new residential buildings in Greve in Chianti (Firenze)', 'Space heating and domestic hot water energy demand in high-level-insulation multi-storey buildings in Tuscany (Italy)', 'Is 2000 W society possible, affordable, and socially acceptable for the Vaud existing school building?', 'Development of simplified method for measuring solar shading performance of windows', 'Studies of ecological architecture in China's Loess Plateau region', 'Contemporary mud

  12. Birkhoff normalization

    NARCIS (Netherlands)

    Broer, H.; Hoveijn, I.; Lunter, G.; Vegter, G.

    2003-01-01

    The Birkhoff normal form procedure is a widely used tool for approximating a Hamiltonian systems by a simpler one. This chapter starts out with an introduction to Hamiltonian mechanics, followed by an explanation of the Birkhoff normal form procedure. Finally we discuss several algorithms for

  13. Monitoring of prestressed concrete pressure vessels. II. performance of selected concrete embedment strain meters under normal and extreme environmental conditions

    International Nuclear Information System (INIS)

    Naus, D.J.; Hurtt, C.C.

    1978-10-01

    Unique types of instrumentation are used in prestressed concrete pressure vessels (PCPVs) to measure strains, stresses, deflections, prestressing forces, moisture content, temperatures, and possibly cracking. Their primary purpose is to monitor these complex structures throughout their 20- to 30-year operating lifetime in order to provide continuing assurance of their reliability and safety. Numerous concrete embedment instrumentation systems are available commercially. Since this instrumentation is important in providing continuing assurance of satisfactory performance of PCPVs, the information provided must be reliable. Therefore, laboratory studies were conducted to evaluate the reliability of these commercially available instrumentation systems. This report, the second in a series related to instrumentation embedded in concrete, presents performance-reliability data for 13 types of selected concrete embedment strain meters which were subjected to a variety of loading environments, including unloaded, thermally loaded, simulated PCPV, and extreme environments. Although only a limited number of meters of each type were tested in any one test series, the composite results of the investigation indicate that the majority of these meters would not be able to provide reliable data throughout the 20- to 30-year anticipated operating life of a PCPV. Specific conclusions drawn from the study are: (1) Improved corrosion-resistant materials and sealing techniques should be developed for meters that are to be used in PCPV environments. (2) There is a need for the development of meters that are capable of surviving in concretes where temperatures in excess of 66 0 C are present for extended periods of time. (3) Research should be conducted on other measurement techniques, such as inductance, capacitance, and fluidics

  14. Comparison of spectrum normalization techniques for univariate ...

    Indian Academy of Sciences (India)

    Laser-induced breakdown spectroscopy; univariate study; normalization models; stainless steel; standard error of prediction. Abstract. Analytical performance of six different spectrum normalization techniques, namelyinternal normalization, normalization with total light, normalization with background along with their ...

  15. Effects of Delay Duration on the WMS Logical Memory Performance of Older Adults with Probable Alzheimer's Disease, Probable Vascular Dementia, and Normal Cognition.

    Science.gov (United States)

    Montgomery, Valencia; Harris, Katie; Stabler, Anthony; Lu, Lisa H

    2017-05-01

    To examine how the duration of time delay between Wechsler Memory Scale (WMS) Logical Memory I and Logical Memory II (LM) affected participants' recall performance. There are 46,146 total Logical Memory administrations to participants diagnosed with either Alzheimer's disease (AD), vascular dementia (VaD), or normal cognition in the National Alzheimer's Disease Coordinating Center's Uniform Data Set. Only 50% of the sample was administered the standard 20-35 min of delay as specified by WMS-R and WMS-III. We found a significant effect of delay time duration on proportion of information retained for the VaD group compared to its control group, which remained after adding LMI raw score as a covariate. There was poorer retention of information with longer delay for this group. This association was not as strong for the AD and cognitively normal groups. A 24.5-min delay was most optimal for differentiating AD from VaD participants (47.7% classification accuracy), an 18.5-min delay was most optimal for differentiating AD versus normal participants (51.7% classification accuracy), and a 22.5-min delay was most optimal for differentiating VaD versus normal participants (52.9% classification accuracy). Considering diagnostic implications, our findings suggest that test administration should incorporate precise tracking of delay periods. We recommend a 20-min delay with 18-25-min range. Poor classification accuracy based on LM data alone is a reminder that story memory performance is only one piece of data that contributes to complex clinical decisions. However, strict adherence to the recommended range yields optimal data for diagnostic decisions. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  16. The Use of Lexical Neighborhood Test (LNT) in the Assessment of Speech Recognition Performance of Cochlear Implantees with Normal and Malformed Cochlea.

    Science.gov (United States)

    Kant, Anjali R; Banik, Arun A

    2017-09-01

    The present study aims to use the model-based test Lexical Neighborhood Test (LNT), to assess speech recognition performance in early and late implanted hearing impaired children with normal and malformed cochlea. The LNT was administered to 46 children with congenital (prelingual) bilateral severe-profound sensorineural hearing loss, using Nucleus 24 cochlear implant. The children were grouped into Group 1-(early implantees with normal cochlea-EI); n = 15, 31/2-61/2 years of age; mean age at implantation-3½ years. Group 2-(late implantees with normal cochlea-LI); n = 15, 6-12 years of age; mean age at implantation-5 years. Group 3-(early implantees with malformed cochlea-EIMC); n = 9; 4.9-10.6 years of age; mean age at implantation-3.10 years. Group 4-(late implantees with malformed cochlea-LIMC); n = 7; 7-12.6 years of age; mean age at implantation-6.3 years. The following were the malformations: dysplastic cochlea, common cavity, Mondini's, incomplete partition-1 and 2 (IP-1 and 2), enlarged IAC. The children were instructed to repeat the words on hearing them. Means of the word and phoneme scores were computed. The LNT can also be used to assess speech recognition performance of hearing impaired children with malformed cochlea. When both easy and hard lists of LNT are considered, although, late implantees (with or without normal cochlea), have achieved higher word scores than early implantees, the differences are not statistically significant. Using LNT for assessing speech recognition enables a quantitative as well as descriptive report of phonological processes used by the children.

  17. Effects of acute lorazepam administration on aminergic activity in normal elderly subjects: relationship to performance effects and apolipoprotein genotype.

    Science.gov (United States)

    Pomara, Nunzio; Willoughby, Lisa M; Hashim, Audrey; Sershen, Henry; Sidtis, John J; Wesnes, Keith; Greenblatt, David J; Lajtha, Abel

    2004-07-01

    The effects of acute lorazepam challenges on plasma (p) HVA, MHPG, and 5-HIAA, and their relationship to drug-induced cognitive and motor deficits and the apolipoprotein (APOE)-epsilon4 allele were examined. Eighteen healthy elderly (8 epsilon4 carriers) received placebo or acute oral lorazepam doses (0.5 mg or 1 mg) in random sequence, 1-week apart. Cognitive assessment and plasma levels of pHVA, pMHPG, and p5-HIAA were determined at baseline and at 1, 2.5, and 5 h postchallenge. There was no drug-to-placebo difference in monoamine levels and no consistent relationship between changes in monoamine levels and cognitive performance, regardless of epsilon4 status. However, the 1.0 mg dose increased p5-HIAA in epsilon4 carriers, whereas it caused a reduction in noncarriers. Higher baseline pMHPG and p5-HIAA levels were associated with better baseline memory. The epsilon4 allele may modulate the effect of lorazepam on p5-HIAA, but further studies are needed to confirm this finding and elucidate its possible significance.

  18. Tightness of the thermal envelope of office and educational buildings; Klimaskaermens taethed i kontor- og undervisningsbygninger

    Energy Technology Data Exchange (ETDEWEB)

    Bergsoee, N.C. (SBi, Aalborg (Denmark)); Radisch, N.H.; Nickel, J.; Treldal, J. (Ramboell Danmark A/S, Koebenhavn (Denmark)); Bundesen, E.W.; Nielsen, Carsten (DanEjendomme, Hellerup (Denmark))

    2011-07-01

    In 2006 tightening of the energy regulations in the Danish Building Regulations were introduced including requirements regarding the tightness of the building envelope. The requirements are, with minor changes, continued in the current Building Regulations, BR10. During the past few years experience has been gained regarding both the actual execution of air tightness measurements and solutions that will lead to more air tight building envelopes. Experiences, however, are primarily related to single family houses. The report presents results of measurements in large buildings and discusses reasons for lack of knowledge and experience on the tightness of the building envelope in large buildings. Apparently, there is a need for dissemination of knowledge on the importance of a tight building envelope both in terms of energy consumption and indoor climate and in terms of the difficulties and costs associated with repairing leaks in a completed envelope. Air tightness must be brought into focus at an early stage in the planning process, and during the construction phase air tightness measurements should be performed, e.g. on facade sections or in parts of the building. The project team has attended a number of measurements in large buildings and further gained access to results of a large number of measurements. In summary, the results show that it is possible to achieve the required tightness, and in most buildings the results are better than the requirement of a maximum of 1.5 l/s per m{sub 2}. (Author)

  19. Geometric optimal design of a magneto-rheological brake considering different shapes for the brake envelope

    International Nuclear Information System (INIS)

    Nguyen, Q H; Lang, V T; Nguyen, N D; Choi, S B

    2014-01-01

    When designing a magneto-rheological brake (MRB), it is well known that the shape of the brake envelope significantly affects the performance characteristics of the brake. In this study, different shapes for the MR brake envelope, such as rectangular, polygonal or spline shape, are considered and the most suitable shape identified. MRBs with different envelope shapes are introduced followed by the derivation of the braking torque based on Bingham-plastic behavior of the magneto-rheological fluid (MRF). Optimization of the design of the MRB with different envelope shapes is then done. The optimization problem is to find the optimal value for the significant geometric dimensions of the MRB that can produce a certain required braking torque while the brake mass is minimized. A finite element analysis integrated with an optimization tool is employed to obtain optimal solutions for the MRBs. From the results, the most suitable shape for the brake envelope is identified and discussed with the reduction of mass. In addition, the results of the analysis are compared with the experimental results to verify the proposed optimal design characteristics. (paper)

  20. Geometric optimal design of a magneto-rheological brake considering different shapes for the brake envelope

    Science.gov (United States)

    Nguyen, Q. H.; Lang, V. T.; Nguyen, N. D.; Choi, S. B.

    2014-01-01

    When designing a magneto-rheological brake (MRB), it is well known that the shape of the brake envelope significantly affects the performance characteristics of the brake. In this study, different shapes for the MR brake envelope, such as rectangular, polygonal or spline shape, are considered and the most suitable shape identified. MRBs with different envelope shapes are introduced followed by the derivation of the braking torque based on Bingham-plastic behavior of the magneto-rheological fluid (MRF). Optimization of the design of the MRB with different envelope shapes is then done. The optimization problem is to find the optimal value for the significant geometric dimensions of the MRB that can produce a certain required braking torque while the brake mass is minimized. A finite element analysis integrated with an optimization tool is employed to obtain optimal solutions for the MRBs. From the results, the most suitable shape for the brake envelope is identified and discussed with the reduction of mass. In addition, the results of the analysis are compared with the experimental results to verify the proposed optimal design characteristics.

  1. Utilizing the building envelope for power generation and conservation

    International Nuclear Information System (INIS)

    Lee, M.C.; Kuo, C.H.; Wang, F.J.

    2016-01-01

    Heat loading of the building envelope is caused by strong solar radiation and incorrect material selection. As a result of the heat loading of the building envelope, the indoor air temperature is increased, resulting in high energy consumption by air conditioners to maintain a comfortable indoor thermal environment. This study explores the use of a hybrid wall integrated with heat collectors (water piping system) and solar thermal power generators, which absorbs solar radiation through water to reduce heat transmission thereby saving energy and generating power. Power generation is achieved by an OD (oscillator device) that installed between a water tank (hot side) and building interior (cold side). The device acts by temperature differences between hot air (expansion) and cold air (contraction). CFD (computational dynamic simulation) was used to assess the effects of the hybrid wall on the interior environment. The results show that exterior heat is absorbed by cool water thereby reducing the heat transmission into the building, resulting in less energy consumption by air conditioners and power generation by use of temperature differences. - Highlights: • This study explores a hybrid building wall to save energy and generate power. • Power generators operated by air pressure change via hot tank and cool interior. • Less energy consumption by air conditioners and heating water. • Performance of CFD simulated results and experiment results are similar. • The energy saving efficiency is around 15 kWh/day via hybrid wall in west façade.

  2. Residential building envelope heat gain and cooling energy requirements

    International Nuclear Information System (INIS)

    Lam, Joseph C.; Tsang, C.L.; Li, Danny H.W.; Cheung, S.O.

    2005-01-01

    We present the energy use situation in Hong Kong from 1979 to 2001. The primary energy requirement (PER) nearly tripled during the 23-year period, rising from 195,405 TJ to 572,684 TJ. Most of the PER was used for electricity generation, and the electricity use in residential buildings rose from 7556 TJ (2099 GWh) to 32,799 TJ (9111 GWh), an increase of 334%. Air-conditioning accounted for about 40% of the total residential sector electricity consumption. A total of 144 buildings completed in the month of June during 1992-2001 were surveyed. Energy performance of the building envelopes was investigated in terms of the overall thermal transfer value (OTTV). To develop the appropriated parameters used in OTTV calculation, long-term measured weather data such as ambient temperature (1960-2001), horizontal global solar radiation (1992-2001) and global solar radiation on vertical surfaces (1996-2001) were examined. The OTTV found varied from 27 to 44 W/m 2 with a mean value of 37.7 W/m 2 . Building energy simulation technique using DOE-2.1E was employed to determine the cooling requirements and hence electricity use for building envelope designs with different OTTVs. It was found that cooling loads and electricity use could be expressed in terms of a simple two-parameter linear regression equation involving OTTV

  3. A novel optical transmission link with DHT-based constant envelope optical OFDM signal

    Science.gov (United States)

    Ma, Jianxin; Liang, Hao

    2013-07-01

    In this paper, we have proposed a novel optical OFDM transmission link that takes advantages of discrete Hartley Transform (DHT) and constant envelope (CE) modulation, obtaining DHT-based constant envelope optical OFDM. The numerical results show that this design achieves better performance when compared with conventional O-OFDM in terms of bit error rate (BER) and peak-to-average power ratio (PAPR). The impact of phase modulation index (PMI) on both PAPR and noise tolerance is investigated. Since the scheme has simplified design, it is believed to be a cost-effective in the practical implement.

  4. Optimized Envelope Tracking Power Supply for Tetra2 Base Station RF Power Amplifier

    DEFF Research Database (Denmark)

    Høyerby, Mikkel Christian Wendelboe; Andersen, Michael Andreas E.

    2008-01-01

    An ultra-fast tracking power supply (UFTPS) for envelope tracking in a 50kHz 64-QAM Tetra2 base station power amplification system is demonstrated. A simple method for optimizing the step response of the PID+PD sliding-mode control system is presented and demonstrated, along with a PLL-based scheme...... application. Also demonstrated is the effect of non-zero UFTPS output impedance on envelope tracking performance. At 13W average (156W peak) RF output, a reduction of DC input power consumption from 93W (14% efficiency) to 54W (24% efficiency) is obtained by moving from a fixed RF power amplifier supply...

  5. Definition and means of maintaining the criticality detectors and alarms portion of the PFP safety envelope

    International Nuclear Information System (INIS)

    White, W.F.

    1997-01-01

    The Criticality Alarm System (CAS) provides continuous detection for high radiation (criticality) events and automatically initiates an evacuation signal to affected personnel. The Safety Envelope (SE) for PFP includes the necessary equipment and the required procedures to ensure the CAS is capable of performing its intended function. This document provides the definition and means of maintaining the SE for PFP related to the CAS. This document also identifies and provides a justification for those portions of the CAS excluded from the PFP Safety Envelope

  6. Modeling speech intelligibility based on the signal-to-noise envelope power ratio

    DEFF Research Database (Denmark)

    Jørgensen, Søren

    of modulation frequency selectivity in the auditory processing of sound with a decision metric for intelligibility that is based on the signal-to-noise envelope power ratio (SNRenv). The proposed speech-based envelope power spectrum model (sEPSM) is demonstrated to account for the effects of stationary...... through three commercially available mobile phones. The model successfully accounts for the performance across the phones in conditions with a stationary speech-shaped background noise, whereas deviations were observed in conditions with “Traffic” and “Pub” noise. Overall, the results of this thesis...

  7. Construction Project Success ranking through the Data Envelopment Analysis

    Directory of Open Access Journals (Sweden)

    Mazyar Zahedi-Seresht

    2014-09-01

    Full Text Available The purpose of this paper is to rank construction projects' success in a post delivery phase. To attain this objective, a data envelopment analysis (DEA approach is used. The model's output is a project success index which is calculated based on five project success criteria. These criteria which are determined by a two-round Delphi questionnaire survey are time performance, cost performance, quality, HSE, and customer satisfaction. The input factors which have effects on the output measures are Organizational Sponsorship, Project Manager Competency, Customer Organization, Project Operational Environment and Organizational Experience. The tool adopted to determine these factors is questionnaire. This model is applied for 9 projects with different importance of output and input factors and the reasonable result is achieved for ranking these projects.

  8. Medicalising normality? Using a simulated dataset to assess the performance of different diagnostic criteria of HIV-associated cognitive impairment

    Science.gov (United States)

    De Francesco, Davide; Leech, Robert; Sabin, Caroline A.; Winston, Alan

    2018-01-01

    Objective The reported prevalence of cognitive impairment remains similar to that reported in the pre-antiretroviral therapy era. This may be partially artefactual due to the methods used to diagnose impairment. In this study, we evaluated the diagnostic performance of the HIV-associated neurocognitive disorder (Frascati criteria) and global deficit score (GDS) methods in comparison to a new, multivariate method of diagnosis. Methods Using a simulated ‘normative’ dataset informed by real-world cognitive data from the observational Pharmacokinetic and Clinical Observations in PeoPle Over fiftY (POPPY) cohort study, we evaluated the apparent prevalence of cognitive impairment using the Frascati and GDS definitions, as well as a novel multivariate method based on the Mahalanobis distance. We then quantified the diagnostic properties (including positive and negative predictive values and accuracy) of each method, using bootstrapping with 10,000 replicates, with a separate ‘test’ dataset to which a pre-defined proportion of ‘impaired’ individuals had been added. Results The simulated normative dataset demonstrated that up to ~26% of a normative control population would be diagnosed with cognitive impairment with the Frascati criteria and ~20% with the GDS. In contrast, the multivariate Mahalanobis distance method identified impairment in ~5%. Using the test dataset, diagnostic accuracy [95% confidence intervals] and positive predictive value (PPV) was best for the multivariate method vs. Frascati and GDS (accuracy: 92.8% [90.3–95.2%] vs. 76.1% [72.1–80.0%] and 80.6% [76.6–84.5%] respectively; PPV: 61.2% [48.3–72.2%] vs. 29.4% [22.2–36.8%] and 33.9% [25.6–42.3%] respectively). Increasing the a priori false positive rate for the multivariate Mahalanobis distance method from 5% to 15% resulted in an increase in sensitivity from 77.4% (64.5–89.4%) to 92.2% (83.3–100%) at a cost of specificity from 94.5% (92.8–95.2%) to 85.0% (81.2–88

  9. Dispersion - does it degrade a pulse envelope

    International Nuclear Information System (INIS)

    Deighton, M.O.

    1985-01-01

    In hostile environments, transmitting information as ultrasonic Lamb wave pulses has advantages, since the stainless steel strip serving as a waveguide is very durable. Besides attenuation, velocity dispersion (inherent in Lamb waves) can be important even in fairly short guides. Theory shows that unlimited propagation of a pulsed r.f. envelope is possible, even with dispersion present. The constant group velocity needed would favour asub(o)-mode pulses over other modes, provided ordinary attenuation is small. An approximate formula indicates the useful range of a pulse, when group velocity does vary. (author)

  10. Snell Envelope with Small Probability Criteria

    Energy Technology Data Exchange (ETDEWEB)

    Del Moral, Pierre, E-mail: Pierre.Del-Moral@inria.fr; Hu, Peng, E-mail: Peng.Hu@inria.fr [Universite de Bordeaux I, Centre INRIA Bordeaux et Sud-Ouest and Institut de Mathematiques de Bordeaux (France); Oudjane, Nadia, E-mail: Nadia.Oudjane@edf.fr [EDF R and D Clamart (France)

    2012-12-15

    We present a new algorithm to compute the Snell envelope in the specific case where the criteria to optimize is associated with a small probability or a rare event. This new approach combines the Stochastic Mesh approach of Broadie and Glasserman with a particle approximation scheme based on a specific change of measure designed to concentrate the computational effort in regions pointed out by the criteria. The theoretical analysis of this new algorithm provides non asymptotic convergence estimates. Finally, the numerical tests confirm the practical interest of this approach.

  11. Assessment of cardiac performance with quantitative radionuclide angiocardiography: sequential left ventricular ejection fraction, normalized left ventricular ejection rate, and regional wall motion

    International Nuclear Information System (INIS)

    Marshall, R.C.; Berger, H.J.; Costin, J.C.; Freedman, G.S.; Wolberg, J.; Cohen, L.S.; Gotischalk, A.; Zaret, B.L.

    1977-01-01

    Sequential quantitative first pass radionuclide angiocardiograms (RA) were used to measure left ventricular ejection fraction (LVEF) and left ventricular ejection rate (LVER), and to assess regional wall motion (RWM) in the anterior (ANT) and left anterior oblique (LAO) positions. Studies were obtained with a computerized multicrystal scintillation camera suitable for acquiring high count-rate data. Background was determined in a new fashion by selecting frames temporally from the left ventricular region of interest time-activity curve. A ''representative'' cardiac cycle was formed by summing together counts over three to six cardiac cycles. From this background corrected, high count-rate ''representative''cardiac cycle, LVEF, LVER, and RWM were determined. In 22 patients with normal sinus rhythm in the absence of significant valvular regurgitation, RA LVEF correlated well with that measured by contrast angiography (r = 0.95). LVER correlated well with LVEF measured at contrast angiography (r = 0.90) and allowed complete separation of those with normal (LVER = 3.4 +- 0.17 sec -1 ) and abnormal (LVER = 1.22 +- 0.11 sec -1 ) (P < 0.001) left ventricular performance. This separation was independent of background. Isoproterenol infusion in five normal subjects caused LVER to increase by 81 +- 17% while LVEF increased by 10 +- 2.0%. RWM was correctly defined in 21/22 patients and 89% of left ventricular segments with abnormal wall motion

  12. Arterial pressure measurement: Is the envelope curve of the oscillometric method influenced by arterial stiffness?

    International Nuclear Information System (INIS)

    Gelido, G; Angiletta, S; Pujalte, A; Quiroga, P; Cornes, P; Craiem, D

    2007-01-01

    Measurement of peripheral arterial pressure using the oscillometric method is commonly used by professionals as well as by patients in their homes. This non invasive automatic method is fast, efficient and the required equipment is affordable with a low cost. The measurement method consists of obtaining parameters from a calibrated decreasing curve that is modulated by heart beats witch appear when arterial pressure reaches the cuff pressure. Diastolic, mean and systolic pressures are obtained calculating particular instants from the heart beats envelope curve. In this article we analyze the envelope of this amplified curve to find out if its morphology is related to arterial stiffness in patients. We found, in 33 volunteers, that the envelope waveform width correlates to systolic pressure (r=0.4, p<0.05), to pulse pressure (r=0.6, p<0.05) and to pulse pressure normalized to systolic pressure (r=0.6, p<0.05). We believe that the morphology of the heart beats envelope curve obtained with the oscillometric method for peripheral pressure measurement depends on arterial stiffness and can be used to enhance pressure measurements

  13. An Experimental Study of Cavitation Detection in a Centrifugal Pump Using Envelope Analysis

    Science.gov (United States)

    Tan, Chek Zin; Leong, M. Salman

    Cavitation represents one of the most common faults in pumps and could potentially lead to a series of failure in mechanical seal, impeller, bearing, shaft, motor, etc. In this work, an experimental rig was setup to investigate cavitation detection using vibration envelope analysis method, and measured parameters included sound, pressure and flow rate for feasibility of cavitation detection. The experiment testing included 3 operating points of the centrifugal pump (B.E.P, 90% of B.E.P and 80% of B.E.P). Suction pressure of the centrifugal pump was decreased gradually until the inception point of cavitation. Vibration measurements were undertaken at various locations including casing, bearing, suction and discharge flange of the centrifugal pump. Comparisons of envelope spectrums under cavitating and non-cavitating conditions were presented. Envelope analysis was proven useful in detecting cavitation over the 3 testing conditions. During the normal operating condition, vibration peak synchronous to rotational speed was more pronounced. It was however during cavitation condition, the half order sub-harmonic vibration component was clearly evident in the envelope spectrums undertaken at all measurement locations except at the pump bearing. The possible explanation of the strong sub-harmonic (½ of BPF) during cavitation existence in the centrifugal pump was due to insufficient time for the bubbles to collapse completely before the end of the single cycle.

  14. Effects of high-intensity interval training on body composition, aerobic and anaerobic performance and plasma lipids in overweight/obese and normal-weight young men.

    Science.gov (United States)

    Ouerghi, Nejmeddine; Fradj, Mohamed Kacem Ben; Bezrati, Ikram; Khammassi, Marwa; Feki, Moncef; Kaabachi, Naziha; Bouassida, Anissa

    2017-12-01

    To examine the effects of short high-intensity interval training (HIIT) on body composition, physical performance and plasma lipids in overweight/obese compared to normal-weight young men. Nine overweight/obese and nine normal-weight men (control group) aged 17 to 20 years underwent a HIIT programme three times per week for eight weeks. Body composition, indices of aerobic [maximal aerobic velocity (MAV) and maximal oxygen uptake (VO 2max )] and anaerobic [squat jump (SJ), counter-movement jump (CMJ), five-jump test (FJT), 10-m and 30-m sprint] performances, as well as fasting plasma lipids, were assessed in the two groups at PRE and POST HIIT. The HIIT programme resulted in significant reductions in body mass (-1.62%, P=0.016, ES=0.11) and fat mass (-1.59%, P=0.021, ES=0.23) in obese, but not in normal-weight subjects. MAV (+5.55%, P=0.005, ES=0.60 and +2.96%, P=0.009, ES=0.82), VO 2max (+5.27%, P=0.006, ES=0.63 and +2.88%, P=0.009, ES=0.41), FJT (+3.63%, P=0.005, ES=0.28 and +2.94%, P=0.009, ES=0.52), SJ (+4.92%, P=0.009, ES=0.25 and +6.94%, P=0.009, ES=0.70) and CMJ (+6.84%, P=0.014, ES=0.30 and +6.69%, P=0.002, ES=0.64) significantly increased in overweight/obese and normal-weight groups, respectively. 30-m sprint time significantly decreased in both groups (-1.77%, P=0.038, ES=0.12 and -0.72%, P=0.030, ES=0.16). Plasma total cholesterol (-11.8%, P=0.026, ES=0.96), LDL cholesterol (-11.9%, P=0.050, ES=0.77) and triglycerides (-21.3%, P=0.023, ES=1.08) significantly decreased in the obese group, but not in the normal-weight group. The eight-week HIIT programme resulted in a slight improvement in physical fitness and a significant decrease in plasma lipids in the obese. Short duration HIIT may contribute to an improved cardiometabolic profile in the obese.

  15. Assessment of characteristic failure envelopes for intact rock using results from triaxial tests

    OpenAIRE

    Muralha, J.; Lamas, L.

    2014-01-01

    The paper presents contributions to the statistical study of the parameters of the Mohr-Coulomb and Hoek-Brown strength criteria, in order to assess the characteristic failure envelopes for intact rock, based on the results of several sets of triaxial tests performed by LNEC. 10p DBB/NMMR

  16. Integrated modeling and robust control for full-envelope flight of robotic helicopters

    Science.gov (United States)

    La Civita, Marco

    Robotic helicopters have attracted a great deal of interest from the university, the industry, and the military world. They are versatile machines and there is a large number of important missions that they could accomplish. Nonetheless, there are only a handful of documented examples of robotic-helicopter applications in real-world scenarios. This situation is mainly due to the poor flight performance that can be achieved and---more important---guaranteed under automatic control. Given the maturity of control theory, and given the large body of knowledge in helicopter dynamics, it seems that the lack of success in flying high-performance controllers for robotic helicopters, especially by academic groups and by small industries, has nothing to do with helicopters or control theory as such. The problem lies instead in the large amount of time and resources needed to synthesize, test, and implement new control systems with the approach normally followed in the aeronautical industry. This thesis attempts to provide a solution by presenting a modeling and control framework that minimizes the time, cost, and both human and physical resources necessary to design high-performance flight controllers. The work is divided in two main parts. The first consists of the development of a modeling technique that allows the designer to obtain a high-fidelity model adequate for both real-time simulation and controller design, with few flight, ground, and wind-tunnel tests and a modest level of complexity in the dynamic equations. The second consists of the exploitation of the predictive capabilities of the model and of the robust stability and performance guarantees of the Hinfinity loop-shaping control theory to reduce the number of iterations of the design/simulated-evaluation/flight-test-evaluation procedure. The effectiveness of this strategy is demonstrated by designing and flight testing a wide-envelope high-performance controller for the Carnegie Mellon University robotic

  17. Ultraviolet extinction in M-supergiant circumstellar envelopes

    International Nuclear Information System (INIS)

    Buss, R.H. Jr.; Snow, T.P. Jr.

    1986-01-01

    Using International Ultraviolet (IUS) archival low-dispersion spectra, ultraviolet spectral extinctions were derived for the circumstellar envelopes of two M supergiants: HD 60414 and HD 213310. The observed stellar systems belong to a class of widely-separated spectroscopic binaries that are called VV Cephei stars. The total extinction was calculated by dividing the reddened fluxes with unreddened comparison fluxes of similar stars (g B2.5 for HD 213310 and a normalized s+B3 for HD 60414) from the reference atlas. After substracting the interstellar extinctions, which were estimated from the E(B-V) reddening of nearby stars, the resultant circumstellar extinctions were normalized at about 3.5 inverse microns. Not only is the 2175 A extinction bump absent in the circumstellar extinctions, but the far-ultraviolet extinction rise is also absent. The rather flat, ultraviolet extinction curves were interpreted as signatures of a population of noncarbonaceous, oxygen-rich grains with diameters larger than the longest observed wavelength

  18. Envelope as Climate Negotiator: Evaluating adaptive building envelope's capacity to moderate indoor climate and energy

    Science.gov (United States)

    Erickson, James

    Through manipulation of adaptable opportunities available within a given environment, individuals become active participants in managing personal comfort requirements, by exercising control over their comfort without the assistance of mechanical heating and cooling systems. Similarly, continuous manipulation of a building skin's form, insulation, porosity, and transmissivity qualities exerts control over the energy exchanged between indoor and outdoor environments. This research uses four adaptive response variables in a modified software algorithm to explore an adaptive building skin's potential in reacting to environmental stimuli with the purpose of minimizing energy use without sacrificing occupant comfort. Results illustrate that significant energy savings can be realized with adaptive envelopes over static building envelopes even under extreme summer and winter climate conditions; that the magnitude of these savings are dependent on climate and orientation; and that occupant thermal comfort can be improved consistently over comfort levels achieved by optimized static building envelopes. The resulting adaptive envelope's unique climate-specific behavior could inform designers in creating an intelligent kinetic aesthetic that helps facilitate adaptability and resiliency in architecture.

  19. 77 FR 69569 - Special Conditions: Embraer S.A., Model EMB-550 Airplanes; Flight Envelope Protection: Pitch and...

    Science.gov (United States)

    2012-11-20

    ... attitude protection functions through the normal modes of the electronic flight control system that will...-1211; Notice No. 25-12-10-SC] Special Conditions: Embraer S.A., Model EMB-550 Airplanes; Flight Envelope Protection: Pitch and Roll Limiting Functions AGENCY: Federal Aviation Administration (FAA), DOT...

  20. 77 FR 69572 - Special Conditions: Embraer S.A., Model EMB-550 Airplanes; Flight Envelope Protection: High Speed...

    Science.gov (United States)

    2012-11-20

    ... electronic flight control system which contains fly-by-wire control laws, including envelope protections, for... airplane incorporates an overspeed protection system in the normal mode. This mode prevents the pilot from... contain appropriate standards for high speed protection systems. Discussion As further discussed...

  1. 78 FR 11562 - Special Conditions: Embraer S.A., Model EMB-550 Airplanes; Flight Envelope Protection: High Speed...

    Science.gov (United States)

    2013-02-19

    ... electronic flight control system which contains fly-by-wire control laws, including envelope protections, for... airplane incorporates an overspeed protection system in the normal mode. This mode prevents the pilot from... contain appropriate standards for high speed protection systems. Discussion As further discussed...

  2. Grain formation in cool stellar envelopes

    International Nuclear Information System (INIS)

    Deguchi, S.

    1980-01-01

    The nucleation and growth of dust grains in the stellar envelope are investigated for the case of oxygen-rich stars, where the mass loss occurs as a result of the radiation pressure on the dust grains. The number density of grains, the final grain sizes, and the final amount of metals remaining in gaseous states are calculated based on the grain-nucleation theory proposed by Yamamoto and Hasegawa and Draine and Salpeter. It is shown that, even if we base our calculations on the Lothe-Pound nucleation rate equation instead of the classical, homogeneous nucleation rate equation, the proposed theory gives a number density of grains quite similar to that based on the classical rate equation. The approximate solution of the flow, in this paper, brings physical insight to the problem of how the formation of grains couples the flow passing the sonic point. The metals in the outer envelope remain in gaseous state by the amount of 1--10% of the initial content for the mass-loss rate of 10 -5 M/sub sun/ yr -1 and by less than 1% for the massloss are less than 3 x 10 -6 M/sub sun/ yr -1 . Species of metals condensed onto the grains are also discussed

  3. Bellanca building, Yellowknife : building envelope retrofit project

    Energy Technology Data Exchange (ETDEWEB)

    Rajewski, G. [A.D. Williams Engineering Inc., Edmonton, AB (Canada)

    2008-07-01

    The Bellanca building is a ten-story, commercial office building, located in Yellowknife, Northwest Territories. The owner was concerned about annual fuel consumption, relative to other buildings of similar size. Tenants reported cold drafts and some ice build-up had been reported in the past, on the exterior of the cladding. In addition, some water penetration had occurred during rainfall. This presentation provided background information on the Bellanca building and discussed a building envelope retrofit project. A.D. Williams was hired in late 2006 in order to provide an opinion on the present condition of the building envelope. This presentation described the site investigation and presented an interior and exterior review of the building. It also presented a thermographic survey in order to map thermal anomalies and establish trends. Following acceptance of the report on findings, one of five options was selected for further development. This included removal of existing cladding, exterior gypsum wallboard, fiberglass insulation and application of BASF Walltite CT foam, sheathing, rigid insulation, drainage plane and new cladding. The preliminary design was then presented. This paper also described the tender and award of the contract; construction phase; and substantial completion of the project. tabs, figs.

  4. Chemistry of Protostellar Envelopes and Disks

    Science.gov (United States)

    Flores Rivera, Lizxandra; Terebey, Susan; Willacy, Karen

    2018-06-01

    Molecule formation is dynamic during the protostar collapse phase, driven by changes in temperature, density, and UV radiation as gas and dust flows from the envelope onto the forming protoplanetary disk. In this work, we compare physical models based on two different collapse solutions. We modeled the chemistry (created by Karen Willacy) for C18O to see how its abundance changes over time using as primary input parameters the temperature and density profile that were produced by the dust Radiative Transfer (MCRT) model called HOCHUNK3D from Whitney (2003). Given this model, we produce synthetic line emission maps from L1527 IRS to simulate the Class 0/I protostar L1527 IRS using RADMC3D code and compare them with previous observations from ALMA. High concentrations of gas phase molecules of C18O are found within the 20 AU in areas in the envelope that are close to the surface of the disk. In the outermost part of the disk surface, the C18O freezes out beyond 400 AU, showing a much reduced abundance where the temperature profile drops down below 25 K. In cold regions, the radiation field plays an important role in the chemistry.

  5. Solution of K-V envelope equations

    International Nuclear Information System (INIS)

    Anderson, O.A.

    1995-04-01

    The envelope equations for a KV beam with space charge have been analyzed systematically by an e expansion followed by integrations. The focusing profile as a function of axial length is assumed to be symmetric but otherwise arbitrary. Given the bean current, emittance, and peak focusing field, we find the envelopes a(s) and b(s) and obtain , a max , σ, and σ 0 . Explicit results are presented for various truncations of the expansion. The zeroth order results correspond to those from the well-known smooth approximation; the same convenient format is retained for the higher order cases. The first order results, involving single correction terms, give 3--10 times better accuracy and are good to ∼1% at σ 0 = 70 degree. Third order gives a factor of 10--30 improvement over the smooth approximation and derived quantities accurate to ∼1% at σ 0 = 112 degree. The first order expressions are convenient design tools. They lend themselves to variable energy problems and have been applied to the design, construction, and testing of ESQ accelerators at LBL

  6. Solitons, envelope solitons in collisonless plasmas

    International Nuclear Information System (INIS)

    Ichikawa, Y.H.; Watanabe, S.

    1977-08-01

    A review is given to extensive development of theoretical, computational and experimental studies of nonlinear wave propagation in collisionless plasmas. Firstly, the historical experiment of Ikezi et al. is discussed in comparison with theoretical analysis based on the Korteweg-de Vries equation. Systematic discrepancy between the observation and the theoretical prediction suggests that it is necessary to examine such as higher order mode coupling effect and contribution of trapped particles. Secondly, effects of the nonlinear Landau damping on the envelope solution of ion plasma wave is discussed on the basis of theoretical study of Ichikawa-Taniuti, experimental observation of Watanabe and numerical analysis of Yajima et al. Finally, a new type of evolution equation derived for the Alfven wave is examined in some detail. The rigorous solution obtained for this mode represents a new kind of envelope solution, in which both of its phase and amplitude are subject to modulation of comparable spatial extension. In conclusion, the emphasis will be placed on the fact that much more intensive experimental researches are expected to be done, since the powerful methods to disentangle various nonlinear evolution equations are now available for theoretical approach. (auth.)

  7. Neural circuits of eye movements during performance of the visual exploration task, which is similar to the responsive search score task, in schizophrenia patients and normal subjects

    International Nuclear Information System (INIS)

    Nemoto, Yasundo; Matsuda, Tetsuya; Matsuura, Masato

    2004-01-01

    Abnormal exploratory eye movements have been studied as a biological marker for schizophrenia. Using functional MRI (fMRI), we investigated brain activations of 12 healthy and 8 schizophrenic subjects during performance of a visual exploration task that is similar to the responsive search score task to clarify the neural basis of the abnormal exploratory eye movement. Performance data, such as the number of eye movements, the reaction time, and the percentage of correct answers showed no significant differences between the two groups. Only the normal subjects showed activations at the bilateral thalamus and the left anterior medial frontal cortex during the visual exploration tasks. In contrast, only the schizophrenic subjects showed activations at the right anterior cingulate gyms during the same tasks. The activation at the different locations between the two groups, the left anterior medial frontal cortex in normal subjects and the right anterior cingulate gyrus in schizophrenia subjects, was explained by the feature of the visual tasks. Hypoactivation at the bilateral thalamus supports a dysfunctional filtering theory of schizophrenia. (author)

  8. Development and Implementation of a Model-Driven Envelope Protection System for In-Flight Ice Contamination

    Science.gov (United States)

    Gingras, David R.; Barnhart, Billy P.; Martos, Borja; Ratvasky, Thomas P.; Morelli, Eugene

    2011-01-01

    Fatal loss-of-control (LOC) accidents have been directly related to in-flight airframe icing. The prototype system presented in this paper directly addresses the need for real-time onboard envelope protection in icing conditions. The combinations of a-priori information and realtime aerodynamic estimations are shown to provide sufficient input for determining safe limits of the flight envelope during in-flight icing encounters. The Icing Contamination Envelope Protection (ICEPro) system has been designed and implemented to identify degradations in airplane performance and flying qualities resulting from ice contamination and provide safe flight-envelope cues to the pilot. Components of ICEPro are described and results from preliminary tests are presented.

  9. Mechanism of protein import across the chloroplast envelope.

    Science.gov (United States)

    Chen, K; Chen, X; Schnell, D J

    2000-01-01

    The development and maintenance of chloroplasts relies on the contribution of protein subunits from both plastid and nuclear genomes. Most chloroplast proteins are encoded by nuclear genes and are post-translationally imported into the organelle across the double membrane of the chloroplast envelope. Protein import into the chloroplast consists of two essential elements: the specific recognition of the targeting signals (transit sequences) of cytoplasmic preproteins by receptors at the outer envelope membrane and the subsequent translocation of preproteins simultaneously across the double membrane of the envelope. These processes are mediated via the co-ordinate action of protein translocon complexes in the outer (Toc apparatus) and inner (Tic apparatus) envelope membranes.

  10. Adaptive Flight Envelope Estimation and Protection, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Impact Technologies, in collaboration with the Georgia Institute of Technology, proposes to develop and demonstrate an innovative flight envelope estimation and...

  11. Used Nuclear Fuel Loading and Structural Performance Under Normal Conditions of Transport - Modeling, Simulation and Experimental Integration RD&D Plan

    Energy Technology Data Exchange (ETDEWEB)

    Adkins, Harold E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2013-04-01

    Under current U.S. Nuclear Regulatory Commission regulation, it is not sufficient for used nuclear fuel (UNF) to simply maintain its integrity during the storage period, it must maintain its integrity in such a way that it can withstand the physical forces of handling and transportation associated with restaging the fuel and moving it to treatment or recycling facilities, or a geologic repository. Hence it is necessary to understand the performance characteristics of aged UNF cladding and ancillary components under loadings stemming from transport initiatives. Researchers would like to demonstrate that enough information, including experimental support and modeling and simulation capabilities, exists to establish a preliminary determination of UNF structural performance under normal conditions of transport (NCT). This research, development and demonstration (RD&D) plan describes a methodology, including development and use of analytical models, to evaluate loading and associated mechanical responses of UNF rods and key structural components. This methodology will be used to provide a preliminary assessment of the performance characteristics of UNF cladding and ancillary components under rail-related NCT loading. The methodology couples modeling and simulation and experimental efforts currently under way within the Used Fuel Disposition Campaign (UFDC). The methodology will involve limited uncertainty quantification in the form of sensitivity evaluations focused around available fuel and ancillary fuel structure properties exclusively. The work includes collecting information via literature review, soliciting input/guidance from subject matter experts, performing computational analyses, planning experimental measurement and possible execution (depending on timing), and preparing a variety of supporting documents that will feed into and provide the basis for future initiatives. The methodology demonstration will focus on structural performance evaluation of

  12. Effects of high-intensity interval training on body composition, aerobic and anaerobic performance and plasma lipids in overweight/obese and normal-weight young men

    Directory of Open Access Journals (Sweden)

    Nejmeddine Ouerghi

    2017-12-01

    Full Text Available To examine the effects of short high-intensity interval training (HIIT on body composition, physical performance and plasma lipids in overweight/obese compared to normal-weight young men. Nine overweight/ obese and nine normal-weight men (control group aged 17 to 20 years underwent a HIIT programme three times per week for eight weeks. Body composition, indices of aerobic [maximal aerobic velocity (MAV and maximal oxygen uptake (VO 2max ] and anaerobic [squat jump (SJ, counter-movement jump (CMJ, five-jump test (FJT, 10-m and 30-m sprint] performances, as well as fasting plasma lipids, were assessed in the two groups at PRE and POST HIIT. The HIIT programme resulted in significant reductions in body mass (-1.62%, P=0.016, ES=0.11 and fat mass (-1.59%, P=0.021, ES=0.23 in obese, but not in normal-weight subjects. MAV (+5.55%, P=0.005, ES=0.60 and +2.96%, P=0.009, ES=0.82, VO 2max (+5.27%, P=0.006, ES=0.63 and +2.88%, P=0.009, ES=0.41, FJT (+3.63%, P=0.005, ES=0.28 and +2.94%, P=0.009, ES=0.52, SJ (+4.92%, P=0.009, ES=0.25 and +6.94%, P=0.009, ES=0.70 and CMJ (+6.84%, P=0.014, ES=0.30 and +6.69%, P=0.002, ES=0.64 significantly increased in overweight/obese and normal-weight groups, respectively. 30-m sprint time significantly decreased in both groups (-1.77%, P=0.038, ES=0.12 and -0.72%, P=0.030, ES=0.16. Plasma total cholesterol (-11.8%, P=0.026, ES=0.96, LDL cholesterol (-11.9%, P=0.050, ES=0.77 and triglycerides (-21.3%, P=0.023, ES=1.08 significantly decreased in the obese group, but not in the normalweight group. The eight-week HIIT programme resulted in a slight improvement in physical fitness and a significant decrease in plasma lipids in the obese. Short duration HIIT may contribute to an improved cardiometabolic profile in the obese.

  13. Modeling technical efficiency of inshore fishery using data envelopment analysis

    Science.gov (United States)

    Rahman, Rahayu; Zahid, Zalina; Khairi, Siti Shaliza Mohd; Hussin, Siti Aida Sheikh

    2016-10-01

    Fishery industry contributes significantly to the economy of Malaysia. This study utilized Data Envelopment Analysis application in estimating the technical efficiency of fishery in Terengganu, a state on the eastern coast of Peninsular Malaysia, based on multiple output, i.e. total fish landing and income of fishermen with six inputs, i.e. engine power, vessel size, number of trips, number of workers, cost and operation distance. The data were collected by survey conducted between November and December 2014. The decision making units (DMUs) involved 100 fishermen from 10 fishery areas. The result showed that the technical efficiency in Season I (dry season) and Season II (rainy season) were 90.2% and 66.7% respectively. About 27% of the fishermen were rated to be efficient during Season I, meanwhile only 13% of the fishermen achieved full efficiency 100% during Season II. The results also found out that there was a significance difference in the efficiency performance between the fishery areas.

  14. Modeling data irregularities and structural complexities in data envelopment analysis

    CERN Document Server

    Zhu, Joe

    2007-01-01

    In a relatively short period of time, Data Envelopment Analysis (DEA) has grown into a powerful quantitative, analytical tool for measuring and evaluating performance. It has been successfully applied to a whole variety of problems in many different contexts worldwide. This book deals with the micro aspects of handling and modeling data issues in modeling DEA problems. DEA's use has grown with its capability of dealing with complex "service industry" and the "public service domain" types of problems that require modeling of both qualitative and quantitative data. This handbook treatment deals with specific data problems including: imprecise or inaccurate data; missing data; qualitative data; outliers; undesirable outputs; quality data; statistical analysis; software and other data aspects of modeling complex DEA problems. In addition, the book will demonstrate how to visualize DEA results when the data is more than 3-dimensional, and how to identify efficiency units quickly and accurately.

  15. A statistical test for outlier identification in data envelopment analysis

    Directory of Open Access Journals (Sweden)

    Morteza Khodabin

    2010-09-01

    Full Text Available In the use of peer group data to assess individual, typical or best practice performance, the effective detection of outliers is critical for achieving useful results. In these ‘‘deterministic’’ frontier models, statistical theory is now mostly available. This paper deals with the statistical pared sample method and its capability of detecting outliers in data envelopment analysis. In the presented method, each observation is deleted from the sample once and the resulting linear program is solved, leading to a distribution of efficiency estimates. Based on the achieved distribution, a pared test is designed to identify the potential outlier(s. We illustrate the method through a real data set. The method could be used in a first step, as an exploratory data analysis, before using any frontier estimation.

  16. Low-Cost Phase Change Material for Building Envelopes

    Energy Technology Data Exchange (ETDEWEB)

    Abhari, Ramin [Renewable Energy Group

    2015-08-06

    A low-cost PCM process consisting of conversion of fats and oils to PCM-range paraffins, and subsequent “encapsulation” of the paraffin using conventional plastic compounding/pelletizing equipment was demonstrated. The PCM pellets produced were field-tested in a building envelope application. This involved combining the PCM pellets with cellulose insulation, whereby 33% reduction in peak heat flux and 12% reduction in heat gain was observed (average summertime performance). The selling price of the PCM pellets produced according to this low-cost process is expected to be in the $1.50-$3.00/lb range, compared to current encapsulated PCM price of about $7.00/lb. Whole-building simulations using corresponding PCM thermal analysis data suggest a payback time of 8 to 16 years (at current energy prices) for an attic insulation retrofit project in the Phoenix climate area.

  17. Memory performance on the Auditory Inference Span Test is independent of background noise type for young adults with normal hearing at high speech intelligibility.

    Science.gov (United States)

    Rönnberg, Niklas; Rudner, Mary; Lunner, Thomas; Stenfelt, Stefan

    2014-01-01

    Listening in noise is often perceived to be effortful. This is partly because cognitive resources are engaged in separating the target signal from background noise, leaving fewer resources for storage and processing of the content of the message in working memory. The Auditory Inference Span Test (AIST) is designed to assess listening effort by measuring the ability to maintain and process heard information. The aim of this study was to use AIST to investigate the effect of background noise types and signal-to-noise ratio (SNR) on listening effort, as a function of working memory capacity (WMC) and updating ability (UA). The AIST was administered in three types of background noise: steady-state speech-shaped noise, amplitude modulated speech-shaped noise, and unintelligible speech. Three SNRs targeting 90% speech intelligibility or better were used in each of the three noise types, giving nine different conditions. The reading span test assessed WMC, while UA was assessed with the letter memory test. Twenty young adults with normal hearing participated in the study. Results showed that AIST performance was not influenced by noise type at the same intelligibility level, but became worse with worse SNR when background noise was speech-like. Performance on AIST also decreased with increasing memory load level. Correlations between AIST performance and the cognitive measurements suggested that WMC is of more importance for listening when SNRs are worse, while UA is of more importance for listening in easier SNRs. The results indicated that in young adults with normal hearing, the effort involved in listening in noise at high intelligibility levels is independent of the noise type. However, when noise is speech-like and intelligibility decreases, listening effort increases, probably due to extra demands on cognitive resources added by the informational masking created by the speech fragments and vocal sounds in the background noise.

  18. Memory performance on the Auditory Inference Span Test is independent of background noise type for young adults with normal hearing at high speech intelligibility

    Directory of Open Access Journals (Sweden)

    Niklas eRönnberg

    2014-12-01

    Full Text Available Listening in noise is often perceived to be effortful. This is partly because cognitive resources are engaged in separating the target signal from background noise, leaving fewer resources for storage and processing of the content of the message in working memory. The Auditory Inference Span Test (AIST is designed to assess listening effort by measuring the ability to maintain and process heard information. The aim of this study was to use AIST to investigate the effect of background noise types and signal-to-noise ratio (SNR on listening effort, as a function of working memory capacity (WMC and updating ability (UA. The AIST was administered in three types of background noise: steady-state speech-shaped noise, amplitude modulated speech-shaped noise, and unintelligible speech. Three SNRs targeting 90% speech intelligibility or better were used in each of the three noise types, giving nine different conditions. The reading span test assessed WMC, while UA was assessed with the letter memory test. Twenty young adults with normal hearing participated in the study. Results showed that AIST performance was not influenced by noise type at the same intelligibility level, but became worse with worse SNR when background noise was speech-like. Performance on AIST also decreased with increasing MLL. Correlations between AIST performance and the cognitive measurements suggested that WMC is of more importance for listening when SNRs are worse, while UA is of more importance for listening in easier SNRs. The results indicated that in young adults with normal hearing, the effort involved in listening in noise at high intelligibility levels is independent of the noise type. However, when noise is speech-like and intelligibility decreases, listening effort increases, probably due to extra demands on cognitive resources added by the informational masking created by the speech-fragments and vocal sounds in the background noise.

  19. Neural Spike-Train Analyses of the Speech-Based Envelope Power Spectrum Model

    Science.gov (United States)

    Rallapalli, Varsha H.

    2016-01-01

    Diagnosing and treating hearing impairment is challenging because people with similar degrees of sensorineural hearing loss (SNHL) often have different speech-recognition abilities. The speech-based envelope power spectrum model (sEPSM) has demonstrated that the signal-to-noise ratio (SNRENV) from a modulation filter bank provides a robust speech-intelligibility measure across a wider range of degraded conditions than many long-standing models. In the sEPSM, noise (N) is assumed to: (a) reduce S + N envelope power by filling in dips within clean speech (S) and (b) introduce an envelope noise floor from intrinsic fluctuations in the noise itself. While the promise of SNRENV has been demonstrated for normal-hearing listeners, it has not been thoroughly extended to hearing-impaired listeners because of limited physiological knowledge of how SNHL affects speech-in-noise envelope coding relative to noise alone. Here, envelope coding to speech-in-noise stimuli was quantified from auditory-nerve model spike trains using shuffled correlograms, which were analyzed in the modulation-frequency domain to compute modulation-band estimates of neural SNRENV. Preliminary spike-train analyses show strong similarities to the sEPSM, demonstrating feasibility of neural SNRENV computations. Results suggest that individual differences can occur based on differential degrees of outer- and inner-hair-cell dysfunction in listeners currently diagnosed into the single audiological SNHL category. The predicted acoustic-SNR dependence in individual differences suggests that the SNR-dependent rate of susceptibility could be an important metric in diagnosing individual differences. Future measurements of the neural SNRENV in animal studies with various forms of SNHL will provide valuable insight for understanding individual differences in speech-in-noise intelligibility.

  20. Radiative transfer in spherical circumstellar dust envelopes. III. Dust envelope models of some well known infrared stars

    International Nuclear Information System (INIS)

    Apruzese, J.P.

    1975-01-01

    The radiative transfer techniques described elsewhere by the author have been employed to construct dust envelope models of several well known infrared stars. The resulting calculations indicate that the infrared emissivity of circumstellar grains generally must be higher than that which many calculations of small nonsilicate grains yield. This conclusion is dependent to some degree on the (unknown) size of the stellar envelopes considered, but is quite firm in the case of the spatially resolved envelope of IRC+10216. Further observations of the spatial distribution of the infrared radiation from stellar envelopes will be invaluable in deciphering the properties of the circumstellar grains

  1. Effect of normalization methods on the performance of supervised learning algorithms applied to HTSeq-FPKM-UQ data sets: 7SK RNA expression as a predictor of survival in patients with colon adenocarcinoma.

    Science.gov (United States)

    Shahriyari, Leili

    2017-11-03

    One of the main challenges in machine learning (ML) is choosing an appropriate normalization method. Here, we examine the effect of various normalization methods on analyzing FPKM upper quartile (FPKM-UQ) RNA sequencing data sets. We collect the HTSeq-FPKM-UQ files of patients with colon adenocarcinoma from TCGA-COAD project. We compare three most common normalization methods: scaling, standardizing using z-score and vector normalization by visualizing the normalized data set and evaluating the performance of 12 supervised learning algorithms on the normalized data set. Additionally, for each of these normalization methods, we use two different normalization strategies: normalizing samples (files) or normalizing features (genes). Regardless of normalization methods, a support vector machine (SVM) model with the radial basis function kernel had the maximum accuracy (78%) in predicting the vital status of the patients. However, the fitting time of SVM depended on the normalization methods, and it reached its minimum fitting time when files were normalized to the unit length. Furthermore, among all 12 learning algorithms and 6 different normalization techniques, the Bernoulli naive Bayes model after standardizing files had the best performance in terms of maximizing the accuracy as well as minimizing the fitting time. We also investigated the effect of dimensionality reduction methods on the performance of the supervised ML algorithms. Reducing the dimension of the data set did not increase the maximum accuracy of 78%. However, it leaded to discovery of the 7SK RNA gene expression as a predictor of survival in patients with colon adenocarcinoma with accuracy of 78%. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  2. Gap Detection in School-Age Children and Adults: Effects of Inherent Envelope Modulation and the Availability of Cues across Frequency

    Science.gov (United States)

    Buss, Emily; Hall, Joseph W., III; Porter, Heather; Grose, John H.

    2014-01-01

    Purpose: The present study evaluated the effects of inherent envelope modulation and the availability of cues across frequency on behavioral gap detection with noise-band stimuli in school-age children. Method: Listeners were 34 normal-hearing children (ages 5.2-15.6 years) and 12 normal-hearing adults (ages 18.5-28.8 years). Stimuli were…

  3. Polarimetry and physics of Be star envelopes

    International Nuclear Information System (INIS)

    Coyne, G.V.; McLean, I.S.

    1982-01-01

    A review of the most recent developments in polarization studies of Be stars is presented. New polarization techniques for high-resolution spectropolarimetry and for near infrared polarimetry are described and a wide range of new observations are discussed. These include broad-band, intermediate-band and multichannel observations of the continuum polarization of Be stars in the wavelength interval 0.3-2.2 microns, high resolution (0.5 A) line profile polarimetry of a few stars and surveys of many stars for the purposes of statistical analyses. The physical significance of the observational material is discussed in the light of recent theoretical models. Emphasis is placed on the physical and geometrical parameters of Be star envelopes which polarimetry helps to determine. (Auth.)

  4. Enveloping branes and brane-world singularities

    Energy Technology Data Exchange (ETDEWEB)

    Antoniadis, Ignatios; Cotsakis, Spiros [CERN-Theory Division, Department of Physics, Geneva 23 (Switzerland); Klaoudatou, Ifigeneia [University of the Aegean, Research Group of Geometry, Dynamical Systems and Cosmology, Department of Information and Communication Systems Engineering, Samos (Greece)

    2014-12-01

    The existence of envelopes is studied for systems of differential equations in connection with the method of asymptotic splittings which allows one to determine the singularity structure of the solutions. The result is applied to brane-worlds consisting of a 3-brane in a five-dimensional bulk, in the presence of an analog of a bulk perfect fluid parameterizing a generic class of bulk matter. We find that all flat brane solutions suffer from a finite-distance singularity contrary to previous claims. We then study the possibility of avoiding finite-distance singularities by cutting the bulk and gluing regular solutions at the position of the brane. Further imposing physical conditions such as finite Planck mass on the brane and positive energy conditions on the bulk fluid, excludes, however, this possibility as well. (orig.)

  5. Pushing the Envelope of Extreme Space Weather

    Science.gov (United States)

    Pesnell, W. D.

    2014-12-01

    Extreme Space Weather events are large solar flares or geomagnetic storms, which can cost billions of dollars to recover from. We have few examples of such events; the Carrington Event (the solar superstorm) is one of the few that had superlatives in three categories: size of solar flare, drop in Dst, and amplitude of aa. Kepler observations show that stars similar to the Sun can have flares releasing millions of times more energy than an X-class flare. These flares and the accompanying coronal mass ejections could strongly affect the atmosphere surrounding a planet. What level of solar activity would be necessary to strongly affect the atmosphere of the Earth? Can we map out the envelope of space weather along the evolution of the Sun? What would space weather look like if the Sun stopped producing a magnetic field? To what extreme should Space Weather go? These are the extremes of Space Weather explored in this talk.

  6. Data envelopment analysis of randomized ranks

    Directory of Open Access Journals (Sweden)

    Sant'Anna Annibal P.

    2002-01-01

    Full Text Available Probabilities and odds, derived from vectors of ranks, are here compared as measures of efficiency of decision-making units (DMUs. These measures are computed with the goal of providing preliminary information before starting a Data Envelopment Analysis (DEA or the application of any other evaluation or composition of preferences methodology. Preferences, quality and productivity evaluations are usually measured with errors or subject to influence of other random disturbances. Reducing evaluations to ranks and treating the ranks as estimates of location parameters of random variables, we are able to compute the probability of each DMU being classified as the best according to the consumption of each input and the production of each output. Employing the probabilities of being the best as efficiency measures, we stretch distances between the most efficient units. We combine these partial probabilities in a global efficiency score determined in terms of proximity to the efficiency frontier.

  7. Advanced Envelope Research for Factory Built Housing, Phase 3 -- Whole-House Prototyping

    Energy Technology Data Exchange (ETDEWEB)

    Levy, E.; Mullens, M.; Rath, P.

    2014-04-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective envelope designs that can be effectively integrated into the plant production process while meeting the thermal requirements of the 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing new envelope technologies. This work is part of a multi-phase effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three methods for building high performance walls. Phase 2 focused on developing viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped narrow the research focus to perfecting a stud wall design with exterior continuous insulation (CI). Phase 3, completed in two stages, continued the design development effort, exploring and evaluating a range or methods for applying CI to factory built homes. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing. During this phase, a home was built with CI, evaluated, and placed in service. The experience of building a mock up wall section with CI and then constructing on line a prototype home resolved important concerns about how to integrate the material into the production process. First steps were taken toward finding least expensive approaches for incorporating CI in standard factory building practices and a preliminary assessment suggested that even at this early stage the technology is attractive when viewed from a life cycle cost perspective.

  8. Enhanced conformational sampling using enveloping distribution sampling.

    Science.gov (United States)

    Lin, Zhixiong; van Gunsteren, Wilfred F

    2013-10-14

    To lessen the problem of insufficient conformational sampling in biomolecular simulations is still a major challenge in computational biochemistry. In this article, an application of the method of enveloping distribution sampling (EDS) is proposed that addresses this challenge and its sampling efficiency is demonstrated in simulations of a hexa-β-peptide whose conformational equilibrium encompasses two different helical folds, i.e., a right-handed 2.7(10∕12)-helix and a left-handed 3(14)-helix, separated by a high energy barrier. Standard MD simulations of this peptide using the GROMOS 53A6 force field did not reach convergence of the free enthalpy difference between the two helices even after 500 ns of simulation time. The use of soft-core non-bonded interactions in the centre of the peptide did enhance the number of transitions between the helices, but at the same time led to neglect of relevant helical configurations. In the simulations of a two-state EDS reference Hamiltonian that envelops both the physical peptide and the soft-core peptide, sampling of the conformational space of the physical peptide ensures that physically relevant conformations can be visited, and sampling of the conformational space of the soft-core peptide helps to enhance the transitions between the two helices. The EDS simulations sampled many more transitions between the two helices and showed much faster convergence of the relative free enthalpy of the two helices compared with the standard MD simulations with only a slightly larger computational effort to determine optimized EDS parameters. Combined with various methods to smoothen the potential energy surface, the proposed EDS application will be a powerful technique to enhance the sampling efficiency in biomolecular simulations.

  9. Malware Normalization

    OpenAIRE

    Christodorescu, Mihai; Kinder, Johannes; Jha, Somesh; Katzenbeisser, Stefan; Veith, Helmut

    2005-01-01

    Malware is code designed for a malicious purpose, such as obtaining root privilege on a host. A malware detector identifies malware and thus prevents it from adversely affecting a host. In order to evade detection by malware detectors, malware writers use various obfuscation techniques to transform their malware. There is strong evidence that commercial malware detectors are susceptible to these evasion tactics. In this paper, we describe the design and implementation of a malware normalizer ...

  10. Two-dimensional high-performance thin-layer chromatography of tryptic bovine albumin digest using normal- and reverse-phase systems with silanized silica stationary phase.

    Science.gov (United States)

    Gwarda, Radosław Łukasz; Dzido, Tadeusz Henryk

    2013-10-18

    Among many advantages of planar techniques, two-dimensional (2D) separation seems to be the most important for analysis of complex samples. Here we present quick, simple and efficient two-dimensional high-performance thin-layer chromatography (2D HPTLC) of bovine albumin digest using commercial HPTLC RP-18W plates (silica based stationary phase with chemically bonded octadecyl ligands of coverage density 0.5μmol/m(2) from Merck, Darmstadt). We show, that at low or high concentration of water in the mobile phase comprised methanol and some additives the chromatographic systems with the plates mentioned demonstrate normal- or reversed-phase liquid chromatography properties, respectively, for separation of peptides obtained. These two systems show quite different separation selectivity and their combination into 2D HPTLC process provides excellent separation of peptides of the bovine albumin digest. Copyright © 2013 Elsevier B.V. All rights reserved.

  11. Reduction of a 4q35-encoded nuclear envelope protein in muscle differentiation

    International Nuclear Information System (INIS)

    Ostlund, Cecilia; Guan, Tinglu; Figlewicz, Denise A.; Hays, Arthur P.; Worman, Howard J.; Gerace, Larry; Schirmer, Eric C.

    2009-01-01

    Muscular dystrophy and peripheral neuropathy have been linked to mutations in genes encoding nuclear envelope proteins; however, the molecular mechanisms underlying these disorders remain unresolved. Nuclear envelope protein p19A is a protein of unknown function encoded by a gene at chromosome 4q35. p19A levels are significantly reduced in human muscle as cells differentiate from myoblasts to myotubes; however, its levels are not similarly reduced in all differentiation systems tested. Because 4q35 has been linked to facioscapulohumeral muscular dystrophy (FSHD) and some adjacent genes are reportedly misregulated in the disorder, levels of p19A were analyzed in muscle samples from patients with FSHD. Although p19A was increased in most cases, an absolute correlation was not observed. Nonetheless, p19A downregulation in normal muscle differentiation suggests that in the cases where its gene is inappropriately re-activated it could affect muscle differentiation and contribute to disease pathology.

  12. Predicting speech intelligibility in adverse conditions: evaluation of the speech-based envelope power spectrum model

    DEFF Research Database (Denmark)

    Jørgensen, Søren; Dau, Torsten

    2011-01-01

    conditions by comparing predictions to measured data from [Kjems et al. (2009). J. Acoust. Soc. Am. 126 (3), 1415-1426] where speech is mixed with four different interferers, including speech-shaped noise, bottle noise, car noise, and cafe noise. The model accounts well for the differences in intelligibility......The speech-based envelope power spectrum model (sEPSM) [Jørgensen and Dau (2011). J. Acoust. Soc. Am., 130 (3), 1475–1487] estimates the envelope signal-to-noise ratio (SNRenv) of distorted speech and accurately describes the speech recognition thresholds (SRT) for normal-hearing listeners...... observed for the different interferers. None of the standardized models successfully describe these data....

  13. Reduction of a 4q35-encoded nuclear envelope protein in muscle differentiation

    Energy Technology Data Exchange (ETDEWEB)

    Ostlund, Cecilia [Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032 (United States); Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032 (United States); Guan, Tinglu [Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037 (United States); Figlewicz, Denise A. [Department of Neurology, University of Michigan, Ann Arbor, MI 48109 (United States); Hays, Arthur P. [Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032 (United States); Worman, Howard J. [Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032 (United States); Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032 (United States); Gerace, Larry [Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037 (United States); Schirmer, Eric C., E-mail: e.schirmer@ed.ac.uk [Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037 (United States); Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR (United Kingdom)

    2009-11-13

    Muscular dystrophy and peripheral neuropathy have been linked to mutations in genes encoding nuclear envelope proteins; however, the molecular mechanisms underlying these disorders remain unresolved. Nuclear envelope protein p19A is a protein of unknown function encoded by a gene at chromosome 4q35. p19A levels are significantly reduced in human muscle as cells differentiate from myoblasts to myotubes; however, its levels are not similarly reduced in all differentiation systems tested. Because 4q35 has been linked to facioscapulohumeral muscular dystrophy (FSHD) and some adjacent genes are reportedly misregulated in the disorder, levels of p19A were analyzed in muscle samples from patients with FSHD. Although p19A was increased in most cases, an absolute correlation was not observed. Nonetheless, p19A downregulation in normal muscle differentiation suggests that in the cases where its gene is inappropriately re-activated it could affect muscle differentiation and contribute to disease pathology.

  14. Field performance of energy-efficient residential building envelope systems

    Energy Technology Data Exchange (ETDEWEB)

    1992-01-01

    The airtightness of 24 new houses was measured on a regular basis over periods of up to three years to evaluate the structures' air barrier systems and to study the possibility of air barrier degradation, as would be indicated by an increase in the measured air leakage rate. Ten of the houses were built with the polyethylene air barrier system and 14 using an early version of the airtight drywall approach (ADA). The 24 project houses were architecturally similar and of approximately equal size and general layout; stucco was the predominate wall finish.

  15. Field performance of energy-efficient residential building envelope systems

    Energy Technology Data Exchange (ETDEWEB)

    Prowskiw, G.

    1992-05-01

    The air tightness of 24 new houses was measured on a regular basis over periods up to three years to evaluate the structures' air barrier systems and to study the possibility of air barrier degradation, as would be indicated by an increase in the measured leakage rate. Ten of the houses were built with the polyethylene air barrier system and 14 using an early version of the Airtight Drywall Approach (ADA). The 24 project houses were architecturally similar and of approximately equal size and general layout. The airtightness of the polyethylene air barrier houses was found to remain stable over their respective monitoring periods. It was concluded that no evidence could be found to indicate polyethylene is unsuited for use as an air barrier material in residential construction. Although 2 of the 10 houses demonstrated possible, albeit slight, evidence of airtightness degradation, the magnitude of these changes was small and judged not to be of practical significance. All but one of the polyethylene houses met the airtightness requirements of the R-2000 program at the end of their monitoring periods. The project houses with the lowest measured leakage rates were those built with the double wall system and polyethylene barriers. The study also found that the airtightness of the 14 ADA houses remained stable during the monitoring period and it was concluded that no evidence could be found to indicate that the ADA system is unsuited for use in residential construction. Although 6 of the 15 houses displayed possible, but also slight, evidence of airtightness degradation, the magnitude of the changes was small and not of practical significance. All 14 houses met the airtightness requirements of the R-2000 program at the end of their respective monitoring periods. 19 refs., 191 figs., 39 tabs.

  16. Comparison of performance of partial prestressed beam-column subassemblages made of reactive powder concrete and normal concrete materials using finite element models

    Science.gov (United States)

    Nurjannah, S. A.; Budiono, B.; Imran, I.; Sugiri, S.

    2016-04-01

    Research on concrete material continues in several countries and had produced a concrete type of Ultra High Performance Concrete (UHPC) which has a better compressive strength, tensile strength, flexural strength, modulus of elasticity, and durability than normal concrete (NC) namely Reactive Powder Concrete (RPC). Researches on structures using RPC material showed that the RPC structures had a better performance than the NC structures in resisting gravity and lateral cyclic loads. In this study, an experiment was conducted to apply combination of constant axial and lateral cyclic loads to a prototype of RPC interior partial prestressed beam-column subassemblage (prototype of BCS-RPC) with a value of Partial Prestressed Ratio (PPR) of 31.72% on the beam. The test results were compared with finite element model of beam-column subassemblage made of RPC by PPR of 31.72% (BCS-RPC-31.72). Furthermore, there was BCS-RPC modeling with PPR of 21.39% (BCS-RPC-21.39) and beam-column subassemblages made of NC materials modeling with a value of PPR at 21.09% (BCS-NC-21.09) and 32.02% (BCS-NC-32.02). The purpose of this study was to determine the performance of the BCS-RPC models compared to the performance of the BCS-NC models with PPR values below and above 25%, which is the maximum limit of permitted PPR. The results showed that all models of BCS-RPC had a better performance than all models of BCS-NC and the BCS-RPC model with PPR above 25% still behaved ductile and was able to dissipate energy well.

  17. Semiparametric Power Envelopes for Tests of the Unit Root Hypothesis

    DEFF Research Database (Denmark)

    Jansson, Michael

    This paper derives asymptotic power envelopes for tests of the unit root hypothesis in a zero-mean AR(1) model. The power envelopes are derived using the limits of experiments approach and are semiparametric in the sense that the underlying error distribution is treated as an unknown...

  18. Calculation of CWKB envelope in boson and fermion productions

    Indian Academy of Sciences (India)

    Abstract. We present the calculation of envelope of boson and of both low- and high- mass fermion production at the end of inflation when the coherently oscillating inflatons decay into bosons and fermions. We consider three different models of inflation and use. CWKB technique to calculate the envelope to understand the ...

  19. 14 CFR 29.1517 - Limiting height-speed envelope.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Limiting height-speed envelope. 29.1517... Operating Limitations § 29.1517 Limiting height-speed envelope. For Category A rotorcraft, if a range of... following power failure, the range of heights and its variation with forward speed must be established...

  20. Beam envelope profile of non-centrosymmetric polygonal phase space

    International Nuclear Information System (INIS)

    Chen Yinbao; Xie Xi

    1984-01-01

    The general theory of beam envelope profile of non-centrosymmetric polygonal phase space is developed. By means of this theory the beam envelope profile of non-centrosymmetric polygonal phase space can be calculated directly. An example is carried out in detail to show the practical application of the theory

  1. A Spectral Algorithm for Envelope Reduction of Sparse Matrices

    Science.gov (United States)

    Barnard, Stephen T.; Pothen, Alex; Simon, Horst D.

    1993-01-01

    The problem of reordering a sparse symmetric matrix to reduce its envelope size is considered. A new spectral algorithm for computing an envelope-reducing reordering is obtained by associating a Laplacian matrix with the given matrix and then sorting the components of a specified eigenvector of the Laplacian. This Laplacian eigenvector solves a continuous relaxation of a discrete problem related to envelope minimization called the minimum 2-sum problem. The permutation vector computed by the spectral algorithm is a closest permutation vector to the specified Laplacian eigenvector. Numerical results show that the new reordering algorithm usually computes smaller envelope sizes than those obtained from the current standard algorithms such as Gibbs-Poole-Stockmeyer (GPS) or SPARSPAK reverse Cuthill-McKee (RCM), in some cases reducing the envelope by more than a factor of two.

  2. Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins.

    Science.gov (United States)

    Maric, Martina; Haugo, Alison C; Dauer, William; Johnson, David; Roller, Richard J

    2014-07-01

    Herpesvirus infection reorganizes components of the nuclear lamina usually without loss of integrity of the nuclear membranes. We report that wild-type HSV infection can cause dissolution of the nuclear envelope in transformed mouse embryonic fibroblasts that do not express torsinA. Nuclear envelope breakdown is accompanied by an eight-fold inhibition of virus replication. Breakdown of the membrane is much more limited during infection with viruses that lack the gB and gH genes, suggesting that breakdown involves factors that promote fusion at the nuclear membrane. Nuclear envelope breakdown is also inhibited during infection with virus that does not express UL34, but is enhanced when the US3 gene is deleted, suggesting that envelope breakdown may be enhanced by nuclear lamina disruption. Nuclear envelope breakdown cannot compensate for deletion of the UL34 gene suggesting that mixing of nuclear and cytoplasmic contents is insufficient to bypass loss of the normal nuclear egress pathway. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. Normal accidents

    International Nuclear Information System (INIS)

    Perrow, C.

    1989-01-01

    The author has chosen numerous concrete examples to illustrate the hazardousness inherent in high-risk technologies. Starting with the TMI reactor accident in 1979, he shows that it is not only the nuclear energy sector that bears the risk of 'normal accidents', but also quite a number of other technologies and industrial sectors, or research fields. The author refers to the petrochemical industry, shipping, air traffic, large dams, mining activities, and genetic engineering, showing that due to the complexity of the systems and their manifold, rapidly interacting processes, accidents happen that cannot be thoroughly calculated, and hence are unavoidable. (orig./HP) [de

  4. Effects of dietary chlorogenic acid on growth performance, antioxidant capacity of white shrimp Litopenaeus vannamei under normal condition and combined stress of low-salinity and nitrite.

    Science.gov (United States)

    Wang, Yun; Li, Zheng; Li, Jian; Duan, Ya-Fei; Niu, Jin; Wang, Jun; Huang, Zhong; Lin, Hei-Zhao

    2015-04-01

    An eight-week feeding trial followed by an acute combined stress test of low-salinity and nitrite were performed to evaluate effects of chlorogenic acid (CGA) on growth performance and antioxidant capacity of white shrimp Litopenaeus vannamei. Shrimp were randomly allocated in 12 tanks (30 shrimp per tank) and triplicate tanks were fed with a control diet or diets containing different levels of CGA (100, 200 and 400 mg kg(-1) feed) as treatment groups. Growth performance including weight gain (WG), biomass gain (BG), feed conversion ratio (FCR), and feed intake were determined after feeding for 56 days. Antioxidant capacity were evaluated by determining the activity of total antioxidant status (TAS), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) as well as the gene expression of GSH-Px and CAT in the hepatopancreas of shrimp at the end of feeding trial and again at the end of the combined stress test. The results indicated that supplemention of CGA had no significant effects on the growth performance and the activities of TAS, SOD, GSH-Px and CAT in hepatopancreas of shrimp cultured under normal conditions for 56 days. However, compared with the control group, CGA (200, 400 mg kg(-1) feed) significantly improved the resistance of L. vannamei against the combined stress of low-salinity and nitrite, as indicated by the significant (P shrimp treated with CGA in the combined tress test. Our findings suggested that CGA possessed dual-modulatory effects on antioxidant capacity of L. vannamei and could be a potential feed additive that can enhance shrimp resistance against environmental stresses. The recommended application dosage is 200 mg kg(-1) and further studies are needed to clarify the action model of CGA efficiency. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Owners perception on the adoption of building envelope energy efficiency measures in Swedish detached houses

    Energy Technology Data Exchange (ETDEWEB)

    Nair, Gireesh [Ecotechnology, Mid Sweden University, SE-83125 Ostersund (Sweden); Gustavsson, Leif [Ecotechnology, Mid Sweden University, SE-83125 Ostersund (Sweden); Mahapatra, Krushna [Ecotechnology, Mid Sweden University, SE-83125 Ostersund (Sweden)

    2010-07-15

    The paper focuses on Swedish homeowners' need for and perceptions about adopting building envelop energy efficiency measures. The paper is based on a questionnaire survey of 3059 homeowners (response rate of 36%) selected by stratified random sampling during the summer of 2008. The results showed that 70-90% of the respondents had no intention of adopting such a measure over the next 10 years. The main reasons for non-adoption were that homeowners were satisfied with the physical condition, thermal performance, and aesthetics of their existing building envelope components. A greater proportion of respondents perceived that improved attic insulation has more advantages than energy efficient windows and improved wall insulation, but windows were more likely to be installed than improved attic insulation. Respondents gave high priority to economic factors in deciding on an energy efficiency measure. Interpersonal sources, construction companies, installers, and energy advisers were important sources of information for homeowners as they planned to adopt building envelope energy efficiency measures. Policy measures to facilitate the rate of adoption of energy efficient building envelope measures are discussed.

  6. Owners perception on the adoption of building envelope energy efficiency measures in Swedish detached houses

    International Nuclear Information System (INIS)

    Nair, Gireesh; Gustavsson, Leif; Mahapatra, Krushna

    2010-01-01

    The paper focuses on Swedish homeowners' need for and perceptions about adopting building envelop energy efficiency measures. The paper is based on a questionnaire survey of 3059 homeowners (response rate of 36%) selected by stratified random sampling during the summer of 2008. The results showed that 70-90% of the respondents had no intention of adopting such a measure over the next 10 years. The main reasons for non-adoption were that homeowners were satisfied with the physical condition, thermal performance, and aesthetics of their existing building envelope components. A greater proportion of respondents perceived that improved attic insulation has more advantages than energy efficient windows and improved wall insulation, but windows were more likely to be installed than improved attic insulation. Respondents gave high priority to economic factors in deciding on an energy efficiency measure. Interpersonal sources, construction companies, installers, and energy advisers were important sources of information for homeowners as they planned to adopt building envelope energy efficiency measures. Policy measures to facilitate the rate of adoption of energy efficient building envelope measures are discussed.

  7. Owners perception on the adoption of building envelope energy efficiency measures in Swedish detached houses

    Energy Technology Data Exchange (ETDEWEB)

    Nair, Gireesh; Gustavsson, Leif; Mahapatra, Krushna [Ecotechnology, Mid Sweden University, SE-83125 Oestersund (Sweden)

    2010-07-15

    The paper focuses on Swedish homeowners' need for and perceptions about adopting building envelop energy efficiency measures. The paper is based on a questionnaire survey of 3059 homeowners (response rate of 36%) selected by stratified random sampling during the summer of 2008. The results showed that 70-90% of the respondents had no intention of adopting such a measure over the next 10 years. The main reasons for non-adoption were that homeowners were satisfied with the physical condition, thermal performance, and aesthetics of their existing building envelope components. A greater proportion of respondents perceived that improved attic insulation has more advantages than energy efficient windows and improved wall insulation, but windows were more likely to be installed than improved attic insulation. Respondents gave high priority to economic factors in deciding on an energy efficiency measure. Interpersonal sources, construction companies, installers, and energy advisers were important sources of information for homeowners as they planned to adopt building envelope energy efficiency measures. Policy measures to facilitate the rate of adoption of energy efficient building envelope measures are discussed. (author)

  8. Performance of iron–chromium–aluminum alloy surface coatings on Zircaloy 2 under high-temperature steam and normal BWR operating conditions

    Energy Technology Data Exchange (ETDEWEB)

    Zhong, Weicheng; Mouche, Peter A.; Han, Xiaochun [University of Illinois, Department of Nuclear, Radiological, and Plasma Engineering, Urbana, IL 61801 (United States); Heuser, Brent J., E-mail: bheuser@illinois.edu [University of Illinois, Department of Nuclear, Radiological, and Plasma Engineering, Urbana, IL 61801 (United States); Mandapaka, Kiran K.; Was, Gary S. [University of Michigan, Department of Nuclear Engineering and Radiological Sciences, Ann Arbor, MI 48109 (United States)

    2016-03-15

    Iron-chromium-aluminum (FeCrAl) coatings deposited on Zircaloy 2 (Zy2) and yttria-stabilized zirconia (YSZ) by magnetron sputtering have been tested with respect to oxidation weight gain in high-temperature steam. In addition, autoclave testing of FeCrAl-coated Zy2 coupons under pressure-temperature-dissolved oxygen coolant conditions representative of a boiling water reactor (BWR) environment has been performed. Four different FeCrAl compositions have been tested in 700 °C steam; compositions that promote alumina formation inhibited oxidation of the underlying Zy2. Parabolic growth kinetics of alumina on FeCrAl-coated Zy2 is quantified via elemental depth profiling. Autoclave testing under normal BWR operating conditions (288 °C, 9.5 MPa with normal water chemistry) up to 20 days demonstrates observable weight gain over uncoated Zy2 simultaneously exposed to the same environment. However, no FeCrAl film degradation was observed. The 900 °C eutectic in binary Fe–Zr is addressed with the FeCrAl-YSZ system. - Graphical abstract: Weight gain normalized to total sample surface area versus time during 700 °C steam exposure for FeCrAl samples with different composition (A) and Fe/Cr/Al:62/4/34 (B). In both cases, the responses of uncoated Zry2 (Zry2-13A and Zry2-19A) are shown for comparison. This uncoated Zry2 response shows the expected pre-transition quasi-cubic kinetic behavior and eventual breakaway (linear) kinetics. Highlights: • FeCrAl coatings deposited on Zy2 have been tested with respect to oxidation in high-temperature steam. • FeCrAl compositions promoting alumina formation inhibited oxidation of Zy2 and delay weight gain. • Autoclave testing to 20 days of coated Zy2 in a simulated BWR environment demonstrates minimal weight gain and no film degradation. • The 900 °C eutectic in binary Fe-Zr is addressed with the FeCrAl-YSZ system.

  9. The effect of frizzle gene and dwarf gene on reproductive performance of broiler breeder dams under high and normal ambient temperatures.

    Science.gov (United States)

    Sharifi, A R; Horst, P; Simianer, H

    2010-11-01

    In 3 experimental runs, the influence of genotype × temperature interactions on the reproductive traits (sexual maturity, egg production, fertility, hatchability, and chick production) of hens of a broiler breeder dam line carrying major genes for dwarfism (dw-) and frizzle (F) was investigated. In experiments 1 and 2, the hens were caged individually under hot (30°C) and temperate (19°C) temperatures, from wk 18 to 72 of age, whereas in experiment 3, hens were kept under moderate temperature (24°C). Hens in experiment 1 were heterozygous for the frizzle gene, and those in experiments 2 and 3 were homozygous, both with and without the dwarf gene. Hens without the above-mentioned major genes (ffDw-) served as control lines. In experiment 1, the frizzle gene (Ff) had no significant effect on sexual maturity, egg production, fertility, hatchability, and chick number under the 2 environmental conditions. In experiment 2, there was a significant interaction between feathering genotype (FF) and environmental temperature for all traits except sexual maturity. Under heat stress, there was a distinct reduction in all reproductive traits except sexual maturity for normally feathered hens compared with frizzle-feathered hens, whereas under temperate conditions, egg production and number of chicks of the FF genotype were reduced and sexual maturity was delayed. In experiments 1 and 2, the dw- gene showed a depressive effect on the growth of hens. In experiment 1, the interaction between dwarf genotype and environmental temperature for egg production was significant. Under temperate conditions, the egg production of dwarf hens was inferior to that of normally sized birds, whereas under hot temperatures, the egg production of the 2 body sizes did not differ. In experiment 2, for sexual maturity, egg production and fertility locus × locus interactions could be determined. The genotype combining the 2 major genes (FFdw-) proved to be inferior to the normally feathered dwarf

  10. Determination of the structure and composition of Au-Ag bimetallic spherical nanoparticles using single particle ICP-MS measurements performed with normal and high temporal resolution.

    Science.gov (United States)

    Kéri, Albert; Kálomista, Ildikó; Ungor, Ditta; Bélteki, Ádám; Csapó, Edit; Dékány, Imre; Prohaska, Thomas; Galbács, Gábor

    2018-03-01

    In this study, the information that can be obtained by combining normal and high resolution single particle ICP-MS (spICP-MS) measurements for spherical bimetallic nanoparticles (BNPs) was assessed. One commercial certified core-shell Au-Ag nanoparticle and three newly synthesized and fully characterized homogenous alloy Au-Ag nanoparticle batches of different composition were used in the experiments as BNP samples. By scrutinizing the high resolution spICP-MS signal time profiles, it was revealed that the width of the signal peak linearly correlates with the diameter of nanoparticles. It was also observed that the width of the peak for same-size nanoparticles is always significantly larger for Au than for Ag. It was also found that it can be reliably determined whether a BNP is of homogeneus alloy or core-shell structure and that, in the case of the latter, the core comprises of which element. We also assessed the performance of several ICP-MS based analytical methods in the analysis of the quantitative composition of bimetallic nanoparticles. Out of the three methods (normal resolution spICP-MS, direct NP nebulization with solution-mode ICP-MS, and solution-mode ICP-MS after the acid dissolution of the nanoparticles), the best accuracy and precision was achieved by spICP-MS. This method allows the determination of the composition with less than 10% relative inaccuracy and better than 3% precision. The analysis is fast and only requires the usual standard colloids for size calibration. Combining the results from both quantitative and structural analyses, the core diameter and shell thickness of core-shell particles can also be calculated. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Windows and Building Envelope Research and Development: A Roadmap for Emerging Technologies

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-02-01

    This Building Technologies Office (BTO) Research and Development (R&D) Roadmap identifies priority windows and building envelope R&D areas of interest. Cost and performance targets are identified for each key R&D area. The roadmap describes the technical and market challenges to be overcome, R&D activities and milestones, key stakeholders, and potential energy savings that could result if cost and performance targets are met. Methods for improving technology performance and specific strategies for reducing installed costs and mitigating any other market barriers, which would increase the likelihood of mass-market technology adoption, are identified. This roadmap is a useful resource for public and private decision makers evaluating and pursuing high-impact R&D focused on advancing next-generation energy efficient windows and building envelope technologies.

  12. Selecting Energy Efficient Building Envelope Retrofits to Existing Department of Defense Building Using Value Focused Thinking

    National Research Council Canada - National Science Library

    Pratt, David M

    2006-01-01

    ... these facilities that have the greatest potential for energy efficient building envelope retrofits. There are hundreds of various new building envelope technologies available to retrofit an existing building envelope, including window, roof, and wall technologies...

  13. Reconstructing Normality

    DEFF Research Database (Denmark)

    Gildberg, Frederik Alkier; Bradley, Stephen K.; Fristed, Peter Billeskov

    2012-01-01

    Forensic psychiatry is an area of priority for the Danish Government. As the field expands, this calls for increased knowledge about mental health nursing practice, as this is part of the forensic psychiatry treatment offered. However, only sparse research exists in this area. The aim of this study...... was to investigate the characteristics of forensic mental health nursing staff interaction with forensic mental health inpatients and to explore how staff give meaning to these interactions. The project included 32 forensic mental health staff members, with over 307 hours of participant observations, 48 informal....... The intention is to establish a trusting relationship to form behaviour and perceptual-corrective care, which is characterized by staff's endeavours to change, halt, or support the patient's behaviour or perception in relation to staff's perception of normality. The intention is to support and teach the patient...

  14. Pursuing Normality

    DEFF Research Database (Denmark)

    Madsen, Louise Sofia; Handberg, Charlotte

    2018-01-01

    implying an influence on whether to participate in cancer survivorship care programs. Because of "pursuing normality," 8 of 9 participants opted out of cancer survivorship care programming due to prospects of "being cured" and perceptions of cancer survivorship care as "a continuation of the disease......BACKGROUND: The present study explored the reflections on cancer survivorship care of lymphoma survivors in active treatment. Lymphoma survivors have survivorship care needs, yet their participation in cancer survivorship care programs is still reported as low. OBJECTIVE: The aim of this study...... was to understand the reflections on cancer survivorship care of lymphoma survivors to aid the future planning of cancer survivorship care and overcome barriers to participation. METHODS: Data were generated in a hematological ward during 4 months of ethnographic fieldwork, including participant observation and 46...

  15. The limited role of recombination energy in common envelope removal

    Science.gov (United States)

    Grichener, Aldana; Sabach, Efrat; Soker, Noam

    2018-05-01

    We calculate the outward energy transport time by convection and photon diffusion in an inflated common envelope and find this time to be shorter than the envelope expansion time. We conclude therefore that most of the hydrogen recombination energy ends in radiation rather than in kinetic energy of the outflowing envelope. We use the stellar evolution code MESA and inject energy inside the envelope of an asymptotic giant branch star to mimic energy deposition by a spiraling-in stellar companion. During 1.7 years the envelope expands by a factor of more than 2. Along the entire evolution the convection can carry the energy very efficiently outwards, to the radius where radiative transfer becomes more efficient. The total energy transport time stays within several months, shorter than the dynamical time of the envelope. Had we included rapid mass loss, as is expected in the common envelope evolution, the energy transport time would have been even shorter. It seems that calculations that assume that most of the recombination energy ends in the outflowing gas might be inaccurate.

  16. Critical point analysis of phase envelope diagram

    Energy Technology Data Exchange (ETDEWEB)

    Soetikno, Darmadi; Siagian, Ucok W. R. [Department of Petroleum Engineering, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung 40132 (Indonesia); Kusdiantara, Rudy, E-mail: rkusdiantara@s.itb.ac.id; Puspita, Dila, E-mail: rkusdiantara@s.itb.ac.id; Sidarto, Kuntjoro A., E-mail: rkusdiantara@s.itb.ac.id; Soewono, Edy; Gunawan, Agus Y. [Department of Mathematics, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung 40132 (Indonesia)

    2014-03-24

    Phase diagram or phase envelope is a relation between temperature and pressure that shows the condition of equilibria between the different phases of chemical compounds, mixture of compounds, and solutions. Phase diagram is an important issue in chemical thermodynamics and hydrocarbon reservoir. It is very useful for process simulation, hydrocarbon reactor design, and petroleum engineering studies. It is constructed from the bubble line, dew line, and critical point. Bubble line and dew line are composed of bubble points and dew points, respectively. Bubble point is the first point at which the gas is formed when a liquid is heated. Meanwhile, dew point is the first point where the liquid is formed when the gas is cooled. Critical point is the point where all of the properties of gases and liquids are equal, such as temperature, pressure, amount of substance, and others. Critical point is very useful in fuel processing and dissolution of certain chemicals. Here in this paper, we will show the critical point analytically. Then, it will be compared with numerical calculations of Peng-Robinson equation by using Newton-Raphson method. As case studies, several hydrocarbon mixtures are simulated using by Matlab.

  17. Critical point analysis of phase envelope diagram

    International Nuclear Information System (INIS)

    Soetikno, Darmadi; Siagian, Ucok W. R.; Kusdiantara, Rudy; Puspita, Dila; Sidarto, Kuntjoro A.; Soewono, Edy; Gunawan, Agus Y.

    2014-01-01

    Phase diagram or phase envelope is a relation between temperature and pressure that shows the condition of equilibria between the different phases of chemical compounds, mixture of compounds, and solutions. Phase diagram is an important issue in chemical thermodynamics and hydrocarbon reservoir. It is very useful for process simulation, hydrocarbon reactor design, and petroleum engineering studies. It is constructed from the bubble line, dew line, and critical point. Bubble line and dew line are composed of bubble points and dew points, respectively. Bubble point is the first point at which the gas is formed when a liquid is heated. Meanwhile, dew point is the first point where the liquid is formed when the gas is cooled. Critical point is the point where all of the properties of gases and liquids are equal, such as temperature, pressure, amount of substance, and others. Critical point is very useful in fuel processing and dissolution of certain chemicals. Here in this paper, we will show the critical point analytically. Then, it will be compared with numerical calculations of Peng-Robinson equation by using Newton-Raphson method. As case studies, several hydrocarbon mixtures are simulated using by Matlab

  18. The eikonal equation, envelopes and contact transformations

    International Nuclear Information System (INIS)

    Frittelli, Simonetta; Kamran, Niky; Newman, Ezra T

    2003-01-01

    We begin with an arbitrary but given conformal Lorentzian metric on an open neighbourhood, U, of a four-dimensional manifold (spacetime) and study families of solutions of the eikonal equation. In particular, the families that are of interest to us are the complete solutions. Their level surfaces form a two-parameter (points of S 2 ) family of foliations of U. We show that, from such a complete solution, it is possible to derive a pair of second-order PDEs defined solely on the parameter space S 2 , i.e., they have no reference to the spacetime points. We then show that if one uses the classical envelope method for the construction of new complete solutions from any given complete solution, then the new pair of PDEs (found from the new complete solution) is related to the old pair by contact transformations in the second jet bundle over S 2 . Further, we demonstrate that the pair of second-order PDEs obtained in this manner from any complete solution lies in a subclass of all pairs of second-order PDEs defined by the vanishing of a certain function obtained from the pair and is referred to as the generalized-Wuenschmann invariant. For completeness we briefly discuss the analogous issues associated with the eikonal equation in three dimensions. Finally we point out that conformally invariant geometric structures from the Lorentzian manifold have natural counterparts in the second jet bundle over S 2 on which the pair of PDEs lives

  19. Ecosystem functioning is enveloped by hydrometeorological variability.

    Science.gov (United States)

    Pappas, Christoforos; Mahecha, Miguel D; Frank, David C; Babst, Flurin; Koutsoyiannis, Demetris

    2017-09-01

    Terrestrial ecosystem processes, and the associated vegetation carbon dynamics, respond differently to hydrometeorological variability across timescales, and so does our scientific understanding of the underlying mechanisms. Long-term variability of the terrestrial carbon cycle is not yet well constrained and the resulting climate-biosphere feedbacks are highly uncertain. Here we present a comprehensive overview of hydrometeorological and ecosystem variability from hourly to decadal timescales integrating multiple in situ and remote-sensing datasets characterizing extra-tropical forest sites. We find that ecosystem variability at all sites is confined within a hydrometeorological envelope across sites and timescales. Furthermore, ecosystem variability demonstrates long-term persistence, highlighting ecological memory and slow ecosystem recovery rates after disturbances. However, simulation results with state-of-the-art process-based models do not reflect this long-term persistent behaviour in ecosystem functioning. Accordingly, we develop a cross-time-scale stochastic framework that captures hydrometeorological and ecosystem variability. Our analysis offers a perspective for terrestrial ecosystem modelling and paves the way for new model-data integration opportunities in Earth system sciences.

  20. Fullerenes and fulleranes in circumstellar envelopes

    International Nuclear Information System (INIS)

    Zhang, Yong; Kwok, Sun; Sadjadi, SeyedAbdolreza

    2016-01-01

    Three decades of search have recently led to convincing discoveries of cosmic fullerenes. The presence of C_6_0 and C"+ _6_0 in both circumstellar and interstellar environments suggests that these molecules and their derivatives can be efficiently formed in circumstellar envelopes and survive in harsh conditions. Detailed analysis of the infrared bands from fullerenes and their connections with the local properties can provide valuable information on the physical conditions and chemical processes that occurred in the late stages of stellar evolution. The identification of C"+ _6_0 as the carrier of four diffuse interstellar bands (DIBs) suggests that fullerene- related compounds are abundant in interstellar space and are essential for resolving the DIB mystery. Experiments have revealed a high hydrogenation rate when C_6_0 is exposed to atomic hydrogen, motivating the attempt to search for cosmic fulleranes. In this paper, we present a short review of current knowledge of cosmic fullerenes and fulleranes and briefly discuss the implications on circumstellar chemistry. (paper)

  1. Performance of brazilian supermarket companies: a data envelopment analysis approach Desempeño organizacional en el sector de los supermercados brasileños: un analisis apoyado en el dea Desempenho organizacional no setor supermercadista brasileiro: uma análise apoiada em dea

    Directory of Open Access Journals (Sweden)

    Marco Antonio Ferreira de Souza

    2010-06-01

    Full Text Available This article applies Data Envelopment Analysis, DEA, to compare the relative performance of the 100 smallest supermarket companies from the list of the 300 largest in the sector. This is in consideration of relevance that has been given to DEA by academics. Results disclose that all single store companies have performance problems related to economies of scale while chain stores have problems more frequently related to poor technical efficiency. The ten largest supermarket companies have better performance, especially with regard to efficiency of scale, than the ten smallest supermarkets studied.El presente artículo pretende analizar el desempeño de las 100 empresas más pequeñas entre las 300 más grandes del sector de supermercados. En este contexto, se presenta como contribución una discusión del desempeño relativo por medio de la aplicación del Análisis Envolvente de Datos (DEA. Los resultados muestran, entre otras informaciones interesantes, que todos los supermercados con una sola tienda tienen sus problemas de rendimiento relacionados con la escala, mientras que aquellos con más de una tienda presentan más problemas relacionados con la eficiencia técnica. Se advierte que, en general, especialmente en lo que se refiere a la eficiencia de escala, los 10 supermercados más grandes tienen un rendimiento superior en comparación con los 10 más pequeños.Este artigo tem como objetivo analisar o desempenho das 100 menores empresas supermercadistas dentre as 300 maiores do setor. Nesse contexto, apresenta-se como contribuição uma discussão do desempenho relativo por meio da aplicação da Análise Envoltória de Dados (DEA. Os resultados mostram, entre outras informações interessantes, que todos os supermercados com uma loja única têm seus problemas de desempenho relacionados à escala, enquanto os que têm mais de uma loja apresentam problemas relacionados mais

  2. Distinct pathways mediate the sorting of tail-anchored proteins to the plastid outer envelope.

    Directory of Open Access Journals (Sweden)

    Preetinder K Dhanoa

    Full Text Available BACKGROUND: Tail-anchored (TA proteins are a distinct class of membrane proteins that are sorted post-translationally to various organelles and function in a number of important cellular processes, including redox reactions, vesicular trafficking and protein translocation. While the molecular targeting signals and pathways responsible for sorting TA proteins to their correct intracellular destinations in yeasts and mammals have begun to be characterized, relatively little is known about TA protein biogenesis in plant cells, especially for those sorted to the plastid outer envelope. METHODOLOGY/PRINCIPAL FINDINGS: Here we investigated the biogenesis of three plastid TA proteins, including the 33-kDa and 34-kDa GTPases of the translocon at the outer envelope of chloroplasts (Toc33 and Toc34 and a novel 9-kDa protein of unknown function that we define here as an outer envelope TA protein (OEP9. Using a combination of in vivo and in vitro assays we show that OEP9 utilizes a different sorting pathway than that used by Toc33 and Toc34. For instance, while all three TA proteins interact with the cytosolic OEP chaperone/receptor, AKR2A, the plastid targeting information within OEP9 is distinct from that within Toc33 and Toc34. Toc33 and Toc34 also appear to differ from OEP9 in that their insertion is dependent on themselves and the unique lipid composition of the plastid outer envelope. By contrast, the insertion of OEP9 into the plastid outer envelope occurs in a proteinaceous-dependent, but Toc33/34-independent manner and membrane lipids appear to serve primarily to facilitate normal thermodynamic integration of this TA protein. CONCLUSIONS/SIGNIFICANCE: Collectively, the results provide evidence in support of at least two sorting pathways for plastid TA outer envelope proteins and shed light on not only the complex diversity of pathways involved in the targeting and insertion of proteins into plastids, but also the molecular mechanisms that underlie

  3. DATA ENVELOPMENT ANALYSIS OF BANKING SECTOR IN BANGLADESH

    Directory of Open Access Journals (Sweden)

    Md. Rashedul Hoque

    2012-05-01

    Full Text Available Banking sector of Bangladesh is flourishing and contributing to its economy. In this aspect measuring efficiency is important. Data Envelopment Analysis technique is used for this purpose. The data are collected from the annual reports of twenty four different banks in Bangladesh. Data Envelopment Analysis is mainly of two types - constant returns to scale and variable returns to scale. Since this study attempts to maximize output, so the output oriented Data Envelopment Analysis is used. The most efficient bank is one that obtains the highest efficiency score.

  4. Pre-paid envelopes commemorating the 2013 Open Days

    CERN Multimedia

    2013-01-01

    The post office on CERN's Prévessin site is still selling pre-paid envelopes commemorating the 2013 Open Days. Hurry while stocks last!   The special envelopes, which are valid in France for non-priority letters weighing up to 20 grams, are ideal for your Christmas and New Year correspondence. A set of ten envelopes, each featuring a different image, costs € 8.70 or 10 CHF. The post office is located in Building 866 on the Prévessin site and is open Mondays to Thursdays from 9.30 a.m. to 12.30 p.m.

  5. Wechsler Adult Intelligence Scale-III profile in the early stages of Alzheimer's disease: performance in subtests sensitive to and resistant to normal decline with ageing.

    Science.gov (United States)

    Matsuda, Osamu; Saito, Masahiko; Kato, Mayumi; Azami, Hiroki; Shido, Emi

    2015-03-01

    This study examined the significance of age-related subtest scores from the Japanese version of the Wechsler Adult Intelligence Scale-III in patients in the early stages of Alzheimer's disease (AD). The subjects of this study included 58 elderly Japanese persons classified into two groups: AD group (n = 29) and control group (n = 29). These groups did not differ in age, years of education, gender ratio, Hasegawa's Dementia Scale-Revised score, or Full-Scale IQ score. No subject scored below the cut-off point on Hasegawa's Dementia Scale-Revised, a frequently used dementia screen test in Japan. At the index score level, General Ability Index scores were the only scores that differed significantly between the groups, with the AD group scoring significantly lower than the control group (P Wechsler Adult Intelligence Scale-III profile of very early AD may be characterized by weak performance on subtests normally resistant to decline with ageing. © 2014 The Authors. Psychogeriatrics © 2014 Japanese Psychogeriatric Society.

  6. Sample handling and contamination encountered when coupling offline normal phase high performance liquid chromatography fraction collection of petroleum samples to Fourier transform ion cyclotron resonance mass spectrometry.

    Science.gov (United States)

    Oro, Nicole E; Whittal, Randy M; Lucy, Charles A

    2012-09-05

    Normal phase high performance liquid chromatography (HPLC) is used to separate a gas oil petroleum sample, and the fractions are collected offline and analyzed on a high resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (FT-ICR MS). The separation prior to MS analysis dilutes the sample significantly; therefore the fractions need to be prepared properly to achieve the best signal possible. The methods used to prepare the HPLC fractions for MS analysis are described, with emphasis placed on increasing the concentration of analyte species. The dilution effect also means that contamination in the MS spectra needs to be minimized. The contamination from molecular sieves, plastics, soap, etc. and interferences encountered during the offline fraction collection process are described and eliminated. A previously unreported MS contamination of iron formate clusters with a 0.8 mass defect in positive mode electrospray is also described. This interference resulted from the stainless steel tubing in the HPLC system. Contamination resulting from what has tentatively been assigned as palmitoylglycerol and stearoylglycerol was also observed; these compounds have not previously been reported as contaminant peaks. Copyright © 2012 Elsevier B.V. All rights reserved.

  7. Trade off study on different envelope detectors for B-mode imaging

    DEFF Research Database (Denmark)

    Schlaikjer, Malene; Bagge, J. P.; Jensen, Jørgen Arendt

    2003-01-01

    sum of the real and imaginary signals. The four detectors were evaluated on in-vivo data acquired with a B-K Medical 2102 scanner interfaced to the sampling system RASMINE. Three data sets were acquired with three different center frequencies. Hundred images were acquired as the transducer was moved......Generation of B-mode images involves envelope detection of the RF-signals. Various detection algorithms are available. A trade off between performance, price, and complexity determines the choice of algorithm in an ultrasound system. A Hilbert Transform (HT) and a subsequent computation...... of the magnitude give the ideal envelope, but the approach (IDE) is expensive and complex. A rectifier (REC) is a simple, low-cost solution, but the performance is severely degraded (especially in dynamic imaging). This study has investigated the possibility of providing a detector with a complexity and cost close...

  8. Managing the Difficult Soft Tissue Envelope in Facial and Rhinoplasty Surgery.

    Science.gov (United States)

    Kosins, Aaron M; Obagi, Zein E

    2017-02-01

    The nasal soft tissue envelope affects the final rhinoplasty result, and can limit the expected improvement. Currently, no dependable and objective test exists to measure the thickness of the nasal skin and underlying soft tissue. This paper presents a simple, yet reliable method to determine the thickness of the soft tissue envelope. An algorithm is presented for treatment of the dermis and/or soft tissue apart from surgery of the underlying osseocartilaginous structures. Seventy-five patients presenting for primary rhinoplasty underwent visual and ultrasound assessment of their nasal soft tissue envelope. At preoperative evaluation, the Obagi "skin pinch test" was used to assess the thickness of the nasolabial fold and whether or not the skin was oily. Patients were classified based on the pinch thickness. At time of surgery prior to injection of local anesthesia, ultrasonic assessment was done at the nasolabial fold, keystone junction, supratip, and tip to measure the thickness of the nasal dermis and underlying soft tissue. Patients determined to have thin, normal, and thick skin by the "skin pinch test" were found to have a nasolabial fold dermal thickness with an average of 0.7 mm (0.4-1.2 mm), 1.1 mm (0.8-1.8 mm), and 1.4 mm (0.7-2.0 mm). Patients determined to have thin, normal, and thick skin were found to have a dermal thickness at the keystone junction with an average of 0.3 mm (0.2-0.4 mm), 0.5 mm (0.3-1.1 mm), and 0.9 mm (0.6-1.2 mm), respectively. This difference in thickness also translated to the supratip and tip areas measured. However, all areas were also affected by the oiliness of the skin. Soft tissue thickness (SMAS and muscle) underlying the dermis was variable. Patients of non-Caucasian background were more likely to have a thicker soft tissue layer. The "skin pinch test" is an easy and reliable way for the surgeon to evaluate the thickness of the nasal soft tissue envelope. The rhinoplasty surgeon can make decisions pre- and postoperatively

  9. ACCEPTABILITY ENVELOPE FOR METAL HYDRIDE-BASED HYDROGEN STORAGE SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Hardy, B.; Corgnale, C.; Tamburello, D.; Garrison, S.; Anton, D.

    2011-07-18

    The design and evaluation of media based hydrogen storage systems requires the use of detailed numerical models and experimental studies, with significant amount of time and monetary investment. Thus a scoping tool, referred to as the Acceptability Envelope, was developed to screen preliminary candidate media and storage vessel designs, identifying the range of chemical, physical and geometrical parameters for the coupled media and storage vessel system that allow it to meet performance targets. The model which underpins the analysis allows simplifying the storage system, thus resulting in one input-one output scheme, by grouping of selected quantities. Two cases have been analyzed and results are presented here. In the first application the DOE technical targets (Year 2010, Year 2015 and Ultimate) are used to determine the range of parameters required for the metal hydride media and storage vessel. In the second case the most promising metal hydrides available are compared, highlighting the potential of storage systems, utilizing them, to achieve 40% of the 2010 DOE technical target. Results show that systems based on Li-Mg media have the best potential to attain these performance targets.

  10. High resolution and high sensitivity methods for oligosaccharide mapping and characterization by normal phase high performance liquid chromatography following derivatization with highly fluorescent anthranilic acid.

    Science.gov (United States)

    Anumula, K R; Dhume, S T

    1998-07-01

    Facile labeling of oligosaccharides (acidic and neutral) in a nonselective manner was achieved with highly fluorescent anthranilic acid (AA, 2-aminobenzoic acid) (more than twice the intensity of 2-aminobenzamide, AB) for specific detection at very high sensitivity. Quantitative labeling in acetate-borate buffered methanol (approximately pH 5.0) at 80 degreesC for 60 min resulted in negligible or no desialylation of the oligosaccharides. A high resolution high performance liquid chromatographic method was developed for quantitative oligosaccharide mapping on a polymeric-NH2bonded (Astec) column operating under normal phase and anion exchange (NP-HPAEC) conditions. For isolation of oligosaccharides from the map by simple evaporation, the chromatographic conditions developed use volatile acetic acid-triethylamine buffer (approximately pH 4.0) systems. The mapping and characterization technology was developed using well characterized standard glycoproteins. The fluorescent oligosaccharide maps were similar to the maps obtained by the high pH anion-exchange chromatography with pulsed amperometric detection (HPAEC-PAD), except that the fluorescent maps contained more defined peaks. In the map, the oligosaccharides separated into groups based on charge, size, linkage, and overall structure in a manner similar to HPAEC-PAD with contribution of -COOH function from the label, anthranilic acid. However, selectivity of the column for sialic acid linkages was different. A second dimension normal phase HPLC (NP-HPLC) method was developed on an amide column (TSK Gel amide-80) for separation of the AA labeled neutral complex type and isomeric structures of high mannose type oligosaccharides. The oligosaccharides labeled with AA are compatible with biochemical and biophysical techniques, and use of matrix assisted laser desorption mass spectrometry for rapid determination of oligosaccharide mass map of glycoproteins is demonstrated. High resolution of NP-HPAEC and NP-HPLC methods

  11. Improved Detection of Vowel Envelope Frequency Following Responses Using Hotelling's T2 Analysis.

    Science.gov (United States)

    Vanheusden, Frederique J; Bell, Steven L; Chesnaye, Michael A; Simpson, David M

    2018-05-11

    Objective detection of brainstem responses to natural speech stimuli is an important tool for the evaluation of hearing aid fitting, especially in people who may not be able to respond reliably in behavioral tests. Of particular interest is the envelope frequency following response (eFFR), which refers to the EEG response at the stimulus' fundamental frequency (and its harmonics), and here in particular to the response to natural spoken vowel sounds. This article introduces the frequency-domain Hotelling's T (HT2) method for eFFR detection. This method was compared, in terms of sensitivity in detecting eFFRs at the fundamental frequency (HT2_F0), to two different single-channel frequency domain methods (F test on Fourier analyzer (FA) amplitude spectra [FA-F-Test] and magnitude-squared coherence [MSC]) in detecting envelope following responses to natural vowel stimuli in simulated data and EEG data from normal-hearing subjects. Sensitivity was assessed based on the number of detections and the time needed to detect a response for a false-positive rate of 5%. The study also explored whether a single-channel, multifrequency HT2 (HT2_3F) and a multichannel, multifrequency HT2 (HT2_MC) could further improve response detection. Four repeated words were presented sequentially at 70 dB SPL LAeq through ER-2 insert earphones. The stimuli consisted of a prolonged vowel in a /hVd/ structure (where V represents different vowel sounds). Each stimulus was presented over 440 sweeps (220 condensation and 220 rarefaction). EEG data were collected from 12 normal-hearing adult participants. After preprocessing and artifact removal, eFFR detection was compared between the algorithms. For the simulation study, simulated EEG signals were generated by adding random noise at multiple signal to noise ratios (SNRs; 0 to -60dB) to the auditory stimuli as well as to a single sinusoid at the fluctuating and flattened fundamental frequency (f0). For each SNR, 1000 sets of 440 simulated epochs

  12. Flight envelope protection system for unmanned aerial vehicles

    KAUST Repository

    Claudel, Christian G.; Shaqura, Mohammad

    2016-01-01

    Systems and methods to protect the flight envelope in both manual flight and flight by a commercial autopilot are provided. A system can comprise: an inertial measurement unit (IMU); a computing device in data communication with the IMU

  13. that Bind Specifically to Recombinant Envelope Protein of Dengue

    African Journals Online (AJOL)

    Tropical Journal of Pharmaceutical Research June 2015; 14 (6): 997-1003 ... Revised accepted: 30 April 2015. Abstract ... Results: The 45 KDa, 43 KDa and 30 KDa plasma membrane proteins were identified as viral envelope targets.

  14. Early Site Permit Demonstration Program: Plant parameters envelope report

    International Nuclear Information System (INIS)

    1993-03-01

    The Early Site Permit (ESP) Demonstration Program is the nuclear industry's initiative for piloting the early resolution of siting-related issues before the detailed design proceedings of the combined operating license review. The ESP Demonstration Program consists of three phases. The plant parameters envelopes task is part of Phase 1, which addresses the generic review of applicable federal regulations and develops criteria for safety and environmental assessment of potential sites. The plant parameters envelopes identify parameters that characterize the interface between an ALWR design and a potential site, and quantify the interface through values selected from the Utility Requirements Documents, vendor design information, or engineering assessments. When augmented with site-specific information, the plant parameters envelopes provide sufficient information to allow ESPs to be granted based on individual ALWR design information or enveloping design information for the evolutionary, passive, or generic ALWR plants. This document is expected to become a living document when used by future applicants

  15. Transport of Ions Across the Inner Envelope Membrane of Chloroplasts

    International Nuclear Information System (INIS)

    McCarty, R. E.

    2004-01-01

    The technical report outlines the results of nine years of research on how ions cross the inner envelope membrane of chloroplasts. The ions include protons, nitrite, calcium and ferrous iron. Bicarbonate transport was also studied

  16. Modeling of fuel performance and fission product release behavior during HTTR normal operation. A comparative study of the FZJ and JAERI modeling approach

    International Nuclear Information System (INIS)

    Verfondern, Karl; Sumita, Junya; Ueta, Shohei; Sawa, Kazuhiro

    2001-03-01

    For the prediction of fuel performance and fission product release behavior in the High Temperature Engineering Test Reactor, HTTR of the Japan Atomic Energy Research Institute(JAERI), during its normal operation, calculation tools were applied as have been used at the Research Center Juelich (FZJ) in safety analyses for pebble-bed HTGR designs. Calculations were made assuming the HTTR operation with a nominal operation time of 660 efpd including a 110 efpd period with elevated fuel temperatures. Fuel performance calculations by the PANAMA code with given fuel temperature distribution in the core have shown that the additional failure level of about 5x10 -6 is expected which is about twice as much as the as-fabricated through-coatings failure level. Under the extreme safety design conditions, the predicted particle failure fraction in the core increases to about 1x10 -3 in maximum. The diffusive release of metallic fission products from the fuel primarily occurs in the core layer with the maximum fuel temperature (layer 3) whereas there is hardly any contribution from layer 1 except for the recoil fraction. Silver most easily escapes the fuel; the predicted release fractions from the fuel compacts are 10% (expected) and 50% (safety design). The figures for strontium (expected: 1.5x10 -3 ), safety design: 3.1x10 -2 ) and cesium (5.6x10 -4 , 2.9x10 -2 ) reveal as well a significant fraction to originate already from intact particles. Comparison with the calculation based on JAERI's diffusion model for cesium shows a good agreement for the release behavior from the particles. The differences in the results can be explained mainly by the different diffusion coefficients applied. The release into the coolant can not modelled because of the influence of the gap between compact and graphite sleeve lowering the release by a factor of 3 to 10. For the prediction of performance and fission product release behavior of advanced ZrC TRISO particles, more experimental work is

  17. Failure envelope approach for consolidated undrained capacity of shallow foundations

    OpenAIRE

    Vulpe, Cristina; Gourvenec, Susan; Leman, Billy; Fung, Kah Ngii

    2016-01-01

    A generalized framework is applied to predict consolidated undrained VHM failure envelopes for surface circular and strip foundations. The failure envelopes for consolidated undrained conditions are shown to be scaled from those for unconsolidated undrained conditions by the uniaxial consolidated undrained capacities, which are predicted through a theoretical framework based on fundamental critical state soil mechanics. The framework is applied to results from small-strain finite-element anal...

  18. Polymers in cell encapsulation from an enveloped cell perspective.

    Science.gov (United States)

    de Vos, Paul; Lazarjani, Hamideh Aghajani; Poncelet, Denis; Faas, Marijke M

    2014-04-01

    In the past two decades, many polymers have been proposed for producing immunoprotective capsules. Examples include the natural polymers alginate, agarose, chitosan, cellulose, collagen, and xanthan and synthetic polymers poly(ethylene glycol), polyvinyl alcohol, polyurethane, poly(ether-sulfone), polypropylene, sodium polystyrene sulfate, and polyacrylate poly(acrylonitrile-sodium methallylsulfonate). The biocompatibility of these polymers is discussed in terms of tissue responses in both the host and matrix to accommodate the functional survival of the cells. Cells should grow and function in the polymer network as adequately as in their natural environment. This is critical when therapeutic cells from scarce cadaveric donors are considered, such as pancreatic islets. Additionally, the cell mass in capsules is discussed from the perspective of emerging new insights into the release of so-called danger-associated molecular pattern molecules by clumps of necrotic therapeutic cells. We conclude that despite two decades of intensive research, drawing conclusions about which polymer is most adequate for clinical application is still difficult. This is because of the lack of documentation on critical information, such as the composition of the polymer, the presence or absence of confounding factors that induce immune responses, toxicity to enveloped cells, and the permeability of the polymer network. Only alginate has been studied extensively and currently qualifies for application. This review also discusses critical issues that are not directly related to polymers and are not discussed in the other reviews in this issue, such as the functional performance of encapsulated cells in vivo. Physiological endocrine responses may indeed not be expected because of the many barriers that the metabolites encounter when traveling from the blood stream to the enveloped cells and back to circulation. However, despite these diffusion barriers, many studies have shown optimal

  19. Data Envelopment Analysis of different climate policy scenarios

    International Nuclear Information System (INIS)

    Bosetti, Valentina; Buchner, Barbara

    2009-01-01

    Recent developments in the political, scientific and economic debate on climate change suggest that it is of critical importance to develop new approaches able to compare policy scenarios for their environmental effectiveness, their distributive effects, their enforceability, their costs and many other dimensions. This paper discusses a quantitative methodology to assess the relative performance of different climate policy scenarios when accounting for their long-term economic, social and environmental impacts. The proposed procedure is based on Data Envelopment Analysis, here employed in evaluating the relative efficiency of eleven global climate policy scenarios. The methodology provides a promising comparison framework; it can be seen as a way of setting some basic guidelines to frame further debates and negotiations and can be flexibly adopted and modified by decision makers to obtain relevant information for policy design. Three major findings emerge from this analysis: (1) stringent climate policies can outperform less ambitious proposals if all sustainability dimensions are taken into account; (2) a carefully chosen burden-sharing rule is able to bring together climate stabilisation and equity considerations; and (3) the most inefficient strategy results from the failure to negotiate a post-2012 global climate agreement. (author)

  20. Synthetic aperture radar imaging simulator for pulse envelope evaluation

    Science.gov (United States)

    Balster, Eric J.; Scarpino, Frank A.; Kordik, Andrew M.; Hill, Kerry L.

    2017-10-01

    A simulator for spotlight synthetic aperture radar (SAR) image formation is presented. The simulator produces radar returns from a virtual radar positioned at an arbitrary distance and altitude. The radar returns are produced from a source image, where the return is a weighted summation of linear frequency-modulated (LFM) pulse signals delayed by the distance of each pixel in the image to the radar. The imagery is resampled into polar format to ensure consistent range profiles to the position of the radar. The SAR simulator provides a capability enabling the objective analysis of formed SAR imagery, comparing it to an original source image. This capability allows for analysis of various SAR signal processing techniques previously determined by impulse response function (IPF) analysis. The results suggest that IPF analysis provides results that may not be directly related to formed SAR image quality. Instead, the SAR simulator uses image quality metrics, such as peak signal-to-noise ratio (PSNR) and structured similarity index (SSIM), for formed SAR image quality analysis. To showcase the capability of the SAR simulator, it is used to investigate the performance of various envelopes applied to LFM pulses. A power-raised cosine window with a power p=0.35 and roll-off factor of β=0.15 is shown to maximize the quality of the formed SAR images by improving PSNR by 0.84 dB and SSIM by 0.06 from images formed utilizing a rectangular pulse, on average.

  1. Efficiency Assessment of Inbound Tourist Service Using Data Envelopment Analysis

    Directory of Open Access Journals (Sweden)

    Han-Shen Chen

    2018-06-01

    Full Text Available The successful and sustainable development of inbound tourism necessitates a long-term commitment, balancing between tourism supply and tourist demands. This study manipulated a performance appraisal of tourism service quality in Taiwan with Data Envelopment Analysis (DEA by employing input and output constructs to assess service quality efficiency. The empirical results of the estimation of technical efficiency (TE revealed that (1 the domestic tourism market is competitive, but still needs enhancements for tourism service; (2 Mainland Chinese tourists had the highest score among all foreign tourists, followed by Hong Kong and Macau tourists, tourists from other countries, Japanese tourists, and South Korean tourists; and (3 South Korean tourists had higher travel expenditure than others, but felt less satisfaction with travel services, which can be regarded as inefficient. Tourists from other countries had lower travel expenditure, but had higher satisfaction levels, which was considered efficient based on input and output index. The findings could contribute to bridging the gap between research and practice in assessing the efficiency of inbound tourist service. Tourism practitioners should be aware of tourists’ needs and interests, as these could be key fundamentals for improving tourists’ satisfaction with Taiwan’s service offerings.

  2. Control room envelope unfiltered air inleakage test protocols

    International Nuclear Information System (INIS)

    Lagus, P.L.; Grot, R.A.

    1997-01-01

    In 1983, the Advisory Committee on Reactor Safeguards (ACRS) recommended that the US NRC develop a control room HVAC performance testing protocol. To date no such protocol has been forthcoming. Beginning in mid-1994, an effort was funded by NRC under a Small Business Innovation Research (SBIR) grant to develop several simplified test protocols based on the principles of tracer gas testing in order to measure the total unfiltered inleakage entering a CRE during emergency mode operation of the control room ventilation system. These would allow accurate assessment of unfiltered air inleakage as required in SRP 6.4. The continuing lack of a standard protocol is unfortunate since one of the significant parameters required to calculate operator dose is the amount of unfiltered air inleakage into the control room. Often it is assumed that, if the Control Room Envelope (CRE) is maintained at +1/8 in. w.g. differential pressure relative to the surroundings, no significant unfiltered inleakage can occur it is further assumed that inleakage due to door openings is the only source of unfiltered air. 23 refs., 13 figs., 2 tabs

  3. Control room envelope unfiltered air inleakage test protocols

    Energy Technology Data Exchange (ETDEWEB)

    Lagus, P.L. [Lagus Applied Technology, San Diego, CA (United States); Grot, R.A. [Lagus Applied Technology, Olney, MD (United States)

    1997-08-01

    In 1983, the Advisory Committee on Reactor Safeguards (ACRS) recommended that the US NRC develop a control room HVAC performance testing protocol. To date no such protocol has been forthcoming. Beginning in mid-1994, an effort was funded by NRC under a Small Business Innovation Research (SBIR) grant to develop several simplified test protocols based on the principles of tracer gas testing in order to measure the total unfiltered inleakage entering a CRE during emergency mode operation of the control room ventilation system. These would allow accurate assessment of unfiltered air inleakage as required in SRP 6.4. The continuing lack of a standard protocol is unfortunate since one of the significant parameters required to calculate operator dose is the amount of unfiltered air inleakage into the control room. Often it is assumed that, if the Control Room Envelope (CRE) is maintained at +1/8 in. w.g. differential pressure relative to the surroundings, no significant unfiltered inleakage can occur it is further assumed that inleakage due to door openings is the only source of unfiltered air. 23 refs., 13 figs., 2 tabs.

  4. Do projections from bioclimatic envelope models and climate change metrics match?

    DEFF Research Database (Denmark)

    Garcia, Raquel A.; Cabeza, Mar; Altwegg, Res

    2016-01-01

    as indicators of the exposure of species to climate change. Here, we investigate whether these two approaches provide qualitatively similar indications about where biodiversity is potentially most exposed to climate change. Location: Sub-Saharan Africa. Methods: We compared a range of climate change metrics...... for sub-Saharan Africa with ensembles of bioclimatic envelope models for 2723 species of amphibians, snakes, mammals and birds. For each taxonomic group, we performed three comparisons between the two approaches: (1) is projected change in local climatic suitability (models) greater in grid cells...... between the two approaches was found for all taxonomic groups, although it was stronger for species with a narrower climatic envelope breadth. Main conclusions: For sub-Saharan African vertebrates, projected patterns of exposure to climate change given by climate change metrics alone were qualitatively...

  5. Advanced Envelope Research for Factory Built Housing, Phase 3. Whole-House Prototyping

    Energy Technology Data Exchange (ETDEWEB)

    Levy, E. [Advanced Residential Integrated Energy Solutions (ARIES), New York, NY (United States); Mullens, M. [Advanced Residential Integrated Energy Solutions (ARIES), New York, NY (United States); Rath, P. [Advanced Residential Integrated Energy Solutions (ARIES), New York, NY (United States)

    2014-04-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective envelope designs that can be effectively integrated into the plant production process while meeting the thermal requirements of the 2012 IECC standards. This work is part of a multiphase effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three methods for building high performance walls. Phase 2 focused on developing viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped narrow the research focus to perfecting a stud wall design with exterior continuous insulation (CI). This report describes Phase 3, which was completed in two stages and continued the design development effort, exploring and evaluating a range or methods for applying CI to factory built homes. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing. During this phase, a home was built with CI, evaluated, and placed in service. The experience of building a mock up wall section with CI and then constructing on line a prototype home resolved important concerns about how to integrate the material into the production process. First steps were taken toward finding least expensive approaches for incorporating CI in standard factory building practices and a preliminary assessment suggested that even at this early stage the technology is attractive when viewed from a life cycle cost perspective.

  6. Joint Processing of Envelope Alignment and Phase Compensation for Isar Imaging

    Science.gov (United States)

    Chen, Tao; Jin, Guanghu; Dong, Zhen

    2018-04-01

    Range envelope alignment and phase compensation are spilt into two isolated parts in the classical methods of translational motion compensation in Inverse Synthetic Aperture Radar (ISAR) imaging. In classic method of the rotating object imaging, the two reference points of the envelope alignment and the Phase Difference (PD) estimation are probably not the same point, making it difficult to uncouple the coupling term by conducting the correction of Migration Through Resolution Cell (MTRC). In this paper, an improved approach of joint processing which chooses certain scattering point as the sole reference point is proposed to perform with utilizing the Prominent Point Processing (PPP) method. With this end in view, we firstly get the initial image using classical methods from which a certain scattering point can be chose. The envelope alignment and phase compensation using the selected scattering point as the same reference point are subsequently conducted. The keystone transform is thus smoothly applied to further improve imaging quality. Both simulation experiments and real data processing are provided to demonstrate the performance of the proposed method compared with classical method.

  7. Dynamic Exergy Analysis for the Thermal Storage Optimization of the Building Envelope

    Directory of Open Access Journals (Sweden)

    Valentina Bonetti

    2017-01-01

    Full Text Available As a measure of energy “quality”, exergy is meaningful for comparing the potential for thermal storage. Systems containing the same amount of energy could have considerably different capabilities in matching a demand profile, and exergy measures this difference. Exergy stored in the envelope of buildings is central in sustainability because the environment could be an unlimited source of energy if its interaction with the envelope is optimised for maintaining the indoor conditions within comfort ranges. Since the occurring phenomena are highly fluctuating, a dynamic exergy analysis is required; however, dynamic exergy modelling is complex and has not hitherto been implemented in building simulation tools. Simplified energy and exergy assessments are presented for a case study in which thermal storage determines the performance of seven different wall types for utilising nocturnal ventilation as a passive cooling strategy. Hourly temperatures within the walls are obtained with the ESP-r software in free-floating operation and are used to assess the envelope exergy storage capacity. The results for the most suitable wall types were different between the exergy analysis and the more traditional energy performance indicators. The exergy method is an effective technique for selecting the construction type that results in the most favourable free-floating conditions through the analysed passive strategy.

  8. Numerical simulation of phase change material composite wallboard in a multi-layered building envelope

    International Nuclear Information System (INIS)

    Zwanzig, Stephen D.; Lian, Yongsheng; Brehob, Ellen G.

    2013-01-01

    Highlights: ► A numerical method to study the heat transfer through a PCM composite wallboard is presented. ► PCM wallboard can reduce energy consumption and shift peak electricity load. ► There is an optimal location for the PCM wallboard in the building envelop. ► The PCM wallboard performance depends on weather conditions. - Abstract: Phase change materials (PCMs) have the capability to store/release massive latent heat when undergoing phase change. When impregnated or encapsulated into wallboard or concrete systems, PCMs can greatly enhance their thermal energy storage capacity and effective thermal mass. When used in the building envelope PCM wallboard has the potential to improve building operation by reducing the energy requirement for maintaining thermal comfort, downsizing the AC/heating equipment, and shifting the peak load from the electrical grid. In this work we numerically studied the potential of PCM on energy saving for residential homes. For that purpose we solved the one-dimensional, transient heat equation through the multi-layered building envelope using the Crank–Nicolson discretization scheme. A source term is incorporated to account for the thermal-physical properties of the composite PCM wallboard. Using this code we examined a PCM composite wallboard incorporated into the walls and roof of a typical residential building across various climate zones. The PCM performance was studied under all seasonal conditions using the latest typical meteorological year (TMY3) data for exterior boundary conditions. Our simulations show that PCM performance highly depends on the weather conditions, emphasizing the necessity to choose different PCMs at different climate zones. Comparisons were also made between different PCM wallboard locations. Our work shows that there exists an optimal location for PCM placement within building envelope dependent upon the resistance values between the PCM layer and the exterior boundary conditions. We further

  9. HIFISTARS Herschel/HIFI observations of VY Canis Majoris. Molecular-line inventory of the envelope around the largest known star

    NARCIS (Netherlands)

    Alcolea, J.; Bujarrabal, V.; Planesas, P.; Teyssier, D.; Cernicharo, J.; De Beck, E.; Decin, L.; Dominik, C.; Justtanont, K.; de Koter, A.; Marston, A.P.; Melnick, G.; Menten, K.M.; Neufeld, D.A.; Olofsson, H.; Schmidt, M.; Schöier, F.L.; Szczerba, R.; Waters, L.B.F.M.

    2013-01-01

    Aims. The study of the molecular gas in the circumstellar envelopes of evolved stars is normally undertaken by observing lines of CO (and other species) in the millimetre-wave domain. In general, the excitation requirements of the observed lines are low at these wavelengths, and therefore these

  10. The South Carolina bridge-scour envelope curves

    Science.gov (United States)

    Benedict, Stephen T.; Feaster, Toby D.; Caldwell, Andral W.

    2016-09-30

    The U.S. Geological Survey, in cooperation with the South Carolina Department of Transportation, conducted a series of three field investigations to evaluate historical, riverine bridge scour in the Piedmont and Coastal Plain regions of South Carolina. These investigations included data collected at 231 riverine bridges, which lead to the development of bridge-scour envelope curves for clear-water and live-bed components of scour. The application and limitations of the South Carolina bridge-scour envelope curves were documented in four reports, each report addressing selected components of bridge scour. The current investigation (2016) synthesizes the findings of these previous reports into a guidance manual providing an integrated procedure for applying the envelope curves. Additionally, the investigation provides limited verification for selected bridge-scour envelope curves by comparing them to field data collected outside of South Carolina from previously published sources. Although the bridge-scour envelope curves have limitations, they are useful supplementary tools for assessing the potential for scour at riverine bridges in South Carolina.

  11. Solar envelope concepts: moderate density building applications. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Knowles, R.L.; Berry, R.D.

    1980-04-01

    Solar energy utilization in urban areas requires public guarantees that all property owners have direct access to the sun. The study examines the implications of this premise in relation to the need for cities to also encourage or accommodate rebuilding and future development. The public policy mechanism for guaranteeing solar access is conceptualized as a solar zoning envelope that allows the largest possible building bulk on a land parcel without shadowing neighboring properties during specified times. Step-by-step methods for generating solar envelopes are described with extensive drawings, showing a variety of urban platting and lot configurations. Development and design possibilities are examined on a selected set of Los Angeles sites with typically diverse urban characteristics. Envelope attributes suitable for encouraging moderate-density commercial and residential building are examined in the context of two hypothetical but realistic development programs: one for speculative office buildings and one for condominium housing. Numerous illustrations of envelope forms and prototypical building designs are provided. The results of development simulation studies on all test sites are tabulated to show building bulk, density, land-coverage and open space characteristics obtainable under the hypothesized envelopes.

  12. The role of spectral and temporal cues in voice gender discrimination by normal-hearing listeners and cochlear implant users.

    Science.gov (United States)

    Fu, Qian-Jie; Chinchilla, Sherol; Galvin, John J

    2004-09-01

    The present study investigated the relative importance of temporal and spectral cues in voice gender discrimination and vowel recognition by normal-hearing subjects listening to an acoustic simulation of cochlear implant speech processing and by cochlear implant users. In the simulation, the number of speech processing channels ranged from 4 to 32, thereby varying the spectral resolution; the cutoff frequencies of the channels' envelope filters ranged from 20 to 320 Hz, thereby manipulating the available temporal cues. For normal-hearing subjects, results showed that both voice gender discrimination and vowel recognition scores improved as the number of spectral channels was increased. When only 4 spectral channels were available, voice gender discrimination significantly improved as the envelope filter cutoff frequency was increased from 20 to 320 Hz. For all spectral conditions, increasing the amount of temporal information had no significant effect on vowel recognition. Both voice gender discrimination and vowel recognition scores were highly variable among implant users. The performance of cochlear implant listeners was similar to that of normal-hearing subjects listening to comparable speech processing (4-8 spectral channels). The results suggest that both spectral and temporal cues contribute to voice gender discrimination and that temporal cues are especially important for cochlear implant users to identify the voice gender when there is reduced spectral resolution.

  13. Smooth quantile normalization.

    Science.gov (United States)

    Hicks, Stephanie C; Okrah, Kwame; Paulson, Joseph N; Quackenbush, John; Irizarry, Rafael A; Bravo, Héctor Corrada

    2018-04-01

    Between-sample normalization is a critical step in genomic data analysis to remove systematic bias and unwanted technical variation in high-throughput data. Global normalization methods are based on the assumption that observed variability in global properties is due to technical reasons and are unrelated to the biology of interest. For example, some methods correct for differences in sequencing read counts by scaling features to have similar median values across samples, but these fail to reduce other forms of unwanted technical variation. Methods such as quantile normalization transform the statistical distributions across samples to be the same and assume global differences in the distribution are induced by only technical variation. However, it remains unclear how to proceed with normalization if these assumptions are violated, for example, if there are global differences in the statistical distributions between biological conditions or groups, and external information, such as negative or control features, is not available. Here, we introduce a generalization of quantile normalization, referred to as smooth quantile normalization (qsmooth), which is based on the assumption that the statistical distribution of each sample should be the same (or have the same distributional shape) within biological groups or conditions, but allowing that they may differ between groups. We illustrate the advantages of our method on several high-throughput datasets with global differences in distributions corresponding to different biological conditions. We also perform a Monte Carlo simulation study to illustrate the bias-variance tradeoff and root mean squared error of qsmooth compared to other global normalization methods. A software implementation is available from https://github.com/stephaniehicks/qsmooth.

  14. Productivity of public hospitals in Nepal: a data envelopment analysis.

    Science.gov (United States)

    Silwal, Pushkar Raj; Ashton, Toni

    2017-07-20

    Public hospitals in Nepal account for a major share of the total health budget. Therefore, questions are often asked about the performance of these hospitals. Existing measures of performance are limited to historical ratio analyses without any benchmarks. The objective of this study is to explore the trends in inputs, outputs and productivity changes in Nepalese public hospitals from 2011-2012 to 2013-2014. The study was conducted among 32 Nepalese public hospitals (23 district level and 9 higher level) for the three fiscal years from 2011-2012 to 2013-2014. First, basic ratio analyses were conducted for the input and output measures over the study years. Then, Malmquist productivity change scores were obtained using data envelopment analysis. Aggregated as well as separate analyses were conducted for district level and higher level hospitals. Real expenditures of the sampled hospitals declined over the 3-year period from an average of US$ 371 000 in year 1 to US$ 368 730 in year 2 and US$ 328680 in year 3. The average aggregated hospital outputs increased marginally from 8276 in 2011-2012 to 8613 in 2013-2014. The total factor productivity of the study hospitals declined by 6.9% annually from 2011-2012 to 2013-2014. Of the total 32 hospitals, productivity increased in only 12 (37.5%) hospitals and declined in the remaining 20 hospitals. The total factor productivity loss was influenced by a decline in technology change, despite an increase in efficiency. In general, productivity of the study hospitals declined over the study period. Availability and accessibility of accurate, detailed and consistent measures of hospital inputs and outputs is a major challenge for this type of analysis. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  15. Productivity of public hospitals in Nepal: a data envelopment analysis

    Science.gov (United States)

    Ashton, Toni

    2017-01-01

    Objectives Public hospitals in Nepal account for a major share of the total health budget. Therefore, questions are often asked about the performance of these hospitals. Existing measures of performance are limited to historical ratio analyses without any benchmarks. The objective of this study is to explore the trends in inputs, outputs and productivity changes in Nepalese public hospitals from 2011–2012 to 2013–2014. Setting and participants The study was conducted among 32 Nepalese public hospitals (23 district level and 9 higher level) for the three fiscal years from 2011–2012 to 2013–2014. Outcome measures First, basic ratio analyses were conducted for the input and output measures over the study years. Then, Malmquist productivity change scores were obtained using data envelopment analysis. Aggregated as well as separate analyses were conducted for district level and higher level hospitals. Results Real expenditures of the sampled hospitals declined over the 3-year period from an average of US$ 371 000 in year 1 to US$ 368 730 in year 2 and US$ 328680 in year 3. The average aggregated hospital outputs increased marginally from 8276 in 2011–2012 to 8613 in 2013–2014. The total factor productivity of the study hospitals declined by 6.9% annually from 2011–2012 to 2013–2014. Of the total 32 hospitals, productivity increased in only 12 (37.5%) hospitals and declined in the remaining 20 hospitals. The total factor productivity loss was influenced by a decline in technology change, despite an increase in efficiency. Conclusions In general, productivity of the study hospitals declined over the study period. Availability and accessibility of accurate, detailed and consistent measures of hospital inputs and outputs is a major challenge for this type of analysis. PMID:28729314

  16. An on-line normal-phase high performance liquid chromatography method for the rapid detection of radical scavengers in non-polar food matrixes

    NARCIS (Netherlands)

    Zhang, Q.; Klift, van der E.J.C.; Janssen, H.G.; Beek, van T.A.

    2009-01-01

    An on-line method for the rapid pinpointing of radical scavengers in non-polar mixtures like vegetable oils was developed. To avoid problems with dissolving the sample, normal-phase chromatography on bare silica gel was used with mixtures of hexane and methyl tert-butyl ether as the eluent. The high

  17. Validation of Ulchin Units 1, 2 CONTEMPT Model Prior to the Production of EQ Envelope Curve

    International Nuclear Information System (INIS)

    Hwang, Su Hyun; Kim, Min Ki; Hong, Soon Joon; Lee, Byung Chul; Suh, Jeong Kwan; Lee, Jae Yong; Song, Dong Soo

    2010-01-01

    The Ulchin Units 1, 2 will be refurbished with RSG (Replacement of Steam Generator) and PU (Power Uprate). The current EQ (Environmental Qualification) envelope curve should be modified according to RSG and PU. The containment P/T (Pressure/Temperature) analysis in Ulchin Units 1, 2 FSAR was done using EDF computer program PAREO6. PAREO6 uses the same assumptions as the US NRC CONTEMPT program, and the results given by both programs are in good agreement. It is utilized to determine pressure and temperature variations in a PWR containment subsequent to a reactor coolant or secondary system pipe break. But PAREO6 cannot be available to the production of EQ envelope curve, so CONTEMPT code should be used instead of PAREO6. It is essential to validate the CONTEMPT OSG (Original Steam Generator) model prior to the production of EQ envelope curve considering RSG and PU. This study has been performed to validate the CONTEMPT model of Ulchin Units 1, 2 by comparing the CONTEMPT results with the PAERO6 results in Ulchin Units 1, 2 FSAR

  18. Validation of Ulchin Units 1, 2 CONTEMPT Model Prior to the Production of EQ Envelope Curve

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Su Hyun; Kim, Min Ki; Hong, Soon Joon; Lee, Byung Chul [FNC Technology Co., SNU, Seoul (Korea, Republic of); Suh, Jeong Kwan; Lee, Jae Yong; Song, Dong Soo [KEPCO Research Institute, Daejeon (Korea, Republic of)

    2010-10-15

    The Ulchin Units 1, 2 will be refurbished with RSG (Replacement of Steam Generator) and PU (Power Uprate). The current EQ (Environmental Qualification) envelope curve should be modified according to RSG and PU. The containment P/T (Pressure/Temperature) analysis in Ulchin Units 1, 2 FSAR was done using EDF computer program PAREO6. PAREO6 uses the same assumptions as the US NRC CONTEMPT program, and the results given by both programs are in good agreement. It is utilized to determine pressure and temperature variations in a PWR containment subsequent to a reactor coolant or secondary system pipe break. But PAREO6 cannot be available to the production of EQ envelope curve, so CONTEMPT code should be used instead of PAREO6. It is essential to validate the CONTEMPT OSG (Original Steam Generator) model prior to the production of EQ envelope curve considering RSG and PU. This study has been performed to validate the CONTEMPT model of Ulchin Units 1, 2 by comparing the CONTEMPT results with the PAERO6 results in Ulchin Units 1, 2 FSAR

  19. Envelope colour on thermal load in hot humid Hong Kong: Effect of hue, value, and chroma

    Institute of Scientific and Technical Information of China (English)

    VickyCHENG; EdwardNG

    2003-01-01

    Cooling energy consumption of a building can be significantly reduced by limiting solar heat gain through envelope, in which depends on the intensity of impinging solar radiation and on the colour of external surface. Albedo, from the thermal point of view, is the prime parameter of interest; however, it does appear to be too conceptual in practice. Architects, when considering choices of envelope colour, the actual decision is between various colours: yellow, blue, or green rather than a single numerical albedo. This study is to investigate the effect and magnitude of colour, in terms of visual qualities hue, value (lightness), and chroma (saturation), on thermal load of buildings. In the experiment, air temperatures inside test cells painted into different colours were measured, the results suggest that colour attribute: chroma has negligible effect on thermal performance of building envelope, while value has significant thermal effect. The effect of hue, as shown in this study, was insignificant, however further study might be needed as to obtain a clearer picture of its effect.

  20. Characterization and interactome study of white spot syndrome virus envelope protein VP11.

    Directory of Open Access Journals (Sweden)

    Wang-Jing Liu

    Full Text Available White spot syndrome virus (WSSV is a large enveloped virus. The WSSV viral particle consists of three structural layers that surround its core DNA: an outer envelope, a tegument and a nucleocapsid. Here we characterize the WSSV structural protein VP11 (WSSV394, GenBank accession number AF440570, and use an interactome approach to analyze the possible associations between this protein and an array of other WSSV and host proteins. Temporal transcription analysis showed that vp11 is an early gene. Western blot hybridization of the intact viral particles and fractionation of the viral components, and immunoelectron microscopy showed that VP11 is an envelope protein. Membrane topology software predicted VP11 to be a type of transmembrane protein with a highly hydrophobic transmembrane domain at its N-terminal. Based on an immunofluorescence assay performed on VP11-transfected Sf9 cells and a trypsin digestion analysis of the virion, we conclude that, contrary to topology software prediction, the C-terminal of this protein is in fact inside the virion. Yeast two-hybrid screening combined with co-immunoprecipitation assays found that VP11 directly interacted with at least 12 other WSSV structural proteins as well as itself. An oligomerization assay further showed that VP11 could form dimers. VP11 is also the first reported WSSV structural protein to interact with the major nucleocapsid protein VP664.

  1. Comparison of Fe and Ni opacity calculations for a better understanding of pulsating stellar envelopes

    International Nuclear Information System (INIS)

    Gilles, D.; Turck-Chieze, S.; Loisel, G.; Piau, L.; Ducret, J.E.; Poirier, M.; Blenski, T.; Thais, F.; Blancard, C.; Cosse, P.; Faussurier, G.; Gilleron, F.; Pain, J.C.; Porcherot, Q.; Guzik, J.A.; Kilcrease, D.P.; Magee, N.H.; Harris, J.; Busquet, M.; Delahaye, F.; Zeippen, C.J.; Bastiani-Ceccotti, S.

    2011-01-01

    Opacity is an important ingredient of the evolution of stars. The calculation of opacity coefficients is complicated by the fact that the plasma contains partially ionized heavy ions that contribute to opacity dominated by H and He. Up to now, the astrophysical community has greatly benefited from the work of the contributions of Los Alamos, Livermore and the Opacity Project (OP). However unexplained differences of up to 50% in the radiative forces and Rosseland mean values for Fe have been noticed for conditions corresponding to stellar envelopes. Such uncertainty has a real impact on the understanding of pulsating stellar envelopes, on the excitation of modes, and on the identification of the mode frequencies. Temperature and density conditions equivalent to those found in stars can now be produced in laboratory experiments for various atomic species. Recently the photo-absorption spectra of nickel and iron plasmas have been measured during the LULI 2010 campaign, for temperatures between 15 and 40 eV and densities of similar to 3 mg/cm 3 . A large theoretical collaboration, the 'OPAC', has been formed to prepare these experiments. We present here the set of opacity calculations performed by eight different groups for conditions relevant to the LULI 2010 experiment and to astrophysical stellar envelope conditions. (authors)

  2. The Aro 1 mm Survey of the Oxygen-Rich Envelope of Supergiant Star NML Cygnus

    Science.gov (United States)

    Edwards, Jessica L.; Ziurys, L. M.; Woolf, N. J.

    2011-06-01

    Although a number of molecular line surveys of carbon-rich circumstellar envelopes (CSE) have been performed, only one oxygen-rich CSE, that of VY Canis Majoris (VY CMa), has been studied in depth. The Arizona Radio Observatory (ARO) 1 mm survey of VY CMa showed a very different and interesting chemistry dominated by sulfur- and silicon-bearing compounds as well as a number of more exotic species. A similar survey of the oxygen rich star NML Cygnus (NML Cyg) from 215 to 285 GHz is currently under way using the ARO Sub-millimeter Telescope. Initial observations show that this circumstellar envelope appears to be as chemically rich as that of VY CMa. Molecules including 12CO, 13CO, 12CN, 13CN, HCN, HCO+, CS, SO{_2}, SiO and 30SiO have been observed in NML Cyg. Line profiles of this source also suggest that there may be multiple outflows and that the circumstellar envelope is not spherically symmetric. Current results will be presented.

  3. From the Outside-In: the Francisella tularensis Envelope and Virulence

    Directory of Open Access Journals (Sweden)

    Hannah M. Rowe

    2015-12-01

    Full Text Available Francisella tularensis is a highly-infectious bacterium that causes the rapid, and often lethal disease, tularemia. Many studies have been performed to identify and characterize the virulence factors that F. tularensis uses to infect a wide variety of hosts and host cell types, evade immune defenses, and induce severe disease and death. This review focuses on the virulence factors that are present in the F. tularensis envelope, including capsule, LPS, outer membrane, periplasm, inner membrane, secretion systems, and various molecules in each of aforementioned sub-compartments. Whereas no single bacterial molecule or molecular complex single-handedly controls F. tularensis virulence, we review here how diverse bacterial systems work in conjunction to subvert the immune system, attach to and invade host cells, alter phagosome/lysosome maturation pathways, replicate in host cells without being detected, inhibit apoptosis, and induce host cell death for bacterial release and infection of adjacent cells. Given that the F. tularensis envelope is the outermost layer of the bacterium, we highlight herein how many of these molecules directly interact with the host to promote infection and disease. These and future envelope studies are important to advance our collective understanding of F. tularensis virulence mechanisms and offer targets for future vaccine development efforts.

  4. The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation.

    Science.gov (United States)

    Bermeo, Sandra; Al-Saedi, Ahmed; Kassem, Moustapha; Vidal, Christopher; Duque, Gustavo

    2017-12-01

    Mutations in MAN1, a protein of the nuclear envelope, cause bone phenotypes characterized by hyperostosis. The mechanism of this pro-osteogenic phenotype remains unknown. We increased and decreased MAN1 expression in mesenchymal stem cells (MSC) upon which standard osteogenic and adipogenic differentiation were performed. MAN1 knockdown increased osteogenesis and mineralization. In contrast, osteogenesis remained stable upon MAN1 overexpression. Regarding a mechanism, we found that low levels of MAN1 facilitated the nuclear accumulation of regulatory smads and smads-related complexes, with a concurrently high expression of nuclear β-Catenin. In addition, we found adipogenesis to be decreased in both conditions, although predominantly affected by MAN1 overexpression. Finally, lamin A, a protein of the nuclear envelope that regulates MSC differentiation, was unaffected by changes in MAN1. In conclusion, our studies demonstrated that lower levels of MAN1 in differentiating MSC are associated with higher osteogenesis and lower adipogenesis. High levels of MAN1 only affected adipogenesis. These effects could have an important role in the understanding of the role of the proteins of the nuclear envelope in bone formation. J. Cell. Biochem. 118: 4425-4435, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  5. Methodology for the Study of the Envelope Airtightness of Residential Buildings in Spain: A Case Study

    Directory of Open Access Journals (Sweden)

    Feijó-Muñoz Jesús

    2018-03-01

    Full Text Available Air leakage and its impact on the energy performance of dwellings has been broadly studied in countries with cold climates in Europe, US, and Canada. However, there is a lack of knowledge in this field in Mediterranean countries. Current Spanish building regulations establish ventilation rates based on ideal airtight envelopes, causing problems of over-ventilation and substantial energy losses. The aim of this paper is to develop a methodology that allows the characterization of the envelope of the housing stock in Spain in order to adjust ventilation rates taking into consideration air leakage. A methodology that is easily applicable to other countries that consider studying the airtightness of the envelope and its energetic behaviour improvement is proposed. A statistical sampling method has been established to determine the dwellings to be tested, considering relevant variables concerning airtightness: climate zone, year of construction, and typology. The air leakage rate is determined using a standardized building pressurization technique according to European Standard EN 13829. A representative case study has been presented as an example of the implementation of the designed methodology and results are compared to preliminary values obtained from the database.

  6. UNVEILING THE EVOLUTIONARY SEQUENCE FROM INFALLING ENVELOPES TO KEPLERIAN DISKS AROUND LOW-MASS PROTOSTARS

    Energy Technology Data Exchange (ETDEWEB)

    Yen, Hsi-Wei [Institute of Astrophysics, National Taiwan University, Taipei 10617, Taiwan (China); Takakuwa, Shigehisa; Ohashi, Nagayoshi; Ho, Paul T. P., E-mail: hwyen@asiaa.sinica.edu.tw [Academia Sinica Institute of Astronomy and Astrophysics, P.O. Box 23-141, Taipei 10617, Taiwan (China)

    2013-07-20

    We performed Submillimeter Array observations in the C{sup 18}O (2-1) emission line toward six Class 0 and I protostars to study rotational motions of their surrounding envelopes and circumstellar material on 100-1000 AU scales. C{sup 18}O (2-1) emission with intensity peaks located at the protostellar positions is detected toward all six sources. The rotational velocities of the protostellar envelopes as a function of radius were measured from the position-velocity diagrams perpendicular to the outflow directions passing through the protostellar positions. Two Class 0 sources, B335 and NGC 1333 IRAS 4B, show no detectable rotational motion, while L1527 IRS (Class 0/I) and L1448-mm (Class 0) exhibit rotational motions with radial profiles of V{sub rot}{proportional_to}r {sup -1.0{+-}0.2} and {proportional_to}r {sup -1.0{+-}0.1}, respectively. The other Class I sources, TMC-1A and L1489 IRS, exhibit the fastest rotational motions among the sample, and their rotational motions have flatter radial profiles of V{sub rot}{proportional_to}r {sup -0.6{+-}0.1} and {proportional_to}r {sup -0.5{+-}0.1}, respectively. The rotational motions with the radial dependence of {approx}r {sup -1} can be interpreted as rotation with a conserved angular momentum in a dynamically infalling envelope, while those with the radial dependence of {approx}r {sup -0.5} can be interpreted as Keplerian rotation. These observational results demonstrate categorization of rotational motions from infalling envelopes to Keplerian-disk formation. Models of the inside-out collapse where the angular momentum is conserved are discussed and compared with our observational results.

  7. High frequency vibration analysis by the complex envelope vectorization.

    Science.gov (United States)

    Giannini, O; Carcaterra, A; Sestieri, A

    2007-06-01

    The complex envelope displacement analysis (CEDA) is a procedure to solve high frequency vibration and vibro-acoustic problems, providing the envelope of the physical solution. CEDA is based on a variable transformation mapping the high frequency oscillations into signals of low frequency content and has been successfully applied to one-dimensional systems. However, the extension to plates and vibro-acoustic fields met serious difficulties so that a general revision of the theory was carried out, leading finally to a new method, the complex envelope vectorization (CEV). In this paper the CEV method is described, underlying merits and limits of the procedure, and a set of applications to vibration and vibro-acoustic problems of increasing complexity are presented.

  8. Safety analysis to support a safe operating envelope for fuel

    International Nuclear Information System (INIS)

    Gibb, R.A.; Reid, P.J.

    1998-01-01

    This paper presents an approach for defining a safe operating envelope for fuel. 'Safe operating envelope' is defined as an envelope of fuel parameters defined for application in safety analysis that can be related to, or used to define, the acceptable range of fuel conditions due to operational transients or deviations in fuel manufacturing processes. The paper describes the motivation for developing such a methodology. The methodology involved four steps: the update of fission product inventories, the review of sheath failure criteria, a review of input parameters to be used in fuel modelling codes, and the development of an improved fission product release code. This paper discusses the aspects of fuel sheath failure criteria that pertain to operating or manufacturing conditions and to the evaluation and selection of modelling input data. The other steps are not addressed in this paper since they have been presented elsewhere. (author)

  9. A comparison of two Shuttle launch and entry suits - Reach envelope, isokinetic strength, and treadmill tests

    Science.gov (United States)

    Schafer, Lauren E.; Rajulu, Sudhakar L.; Klute, Glenn K.

    1992-01-01

    A quantification has been conducted of any existing differences between the performance, in operational conditions, of the Space Shuttle crew Launch Entry Suit (LES) and the new Advanced Crew Escape Suit (ACES). While LES is a partial-pressure suit, the ACES system which is being considered as a replacement for LES is a full-pressure suit. Three tests have been conducted with six subjects to ascertain the suits' reach envelope, strength, and treadmill performance. No significant operational differences were found between the two suit designs.

  10. The nuclear envelope from basic biology to therapy.

    Science.gov (United States)

    Worman, Howard J; Foisner, Roland

    2010-02-01

    The nuclear envelope has long been a focus of basic research for a highly specialized group of cell biologists. More recently, an expanding group of scientists and physicians have developed a keen interest in the nuclear envelope since mutations in the genes encoding lamins and associated proteins have been shown to cause a diverse range of human diseases often called laminopathies or nuclear envelopathies. Most of these diseases have tissue-selective phenotypes, suggesting that the nuclear envelope must function in cell-type- and developmental-stage-specific processes such as chromatin organization, regulation of gene expression, controlled nucleocytoplasmic transport and response to stress in metazoans. On 22-23 April 2009, Professor Christopher Hutchison organized the 4th British Nuclear Envelope Disease and Chromatin Organization meeting at the College of St Hild and St Bede at Durham University, sponsored by the Biochemical Society. In attendance were investigators with one common interest, the nuclear envelope, but with diverse expertise and training in animal and plant cell biology, genetics, developmental biology and medicine. We were each honoured to be keynote speakers. This issue of Biochemical Society Transactions contains papers written by some of the presenters at this scientifically exciting meeting, held in a bucolic setting where the food was tasty and the wine flowed freely. Perhaps at the end of this excellent meeting more questions were raised than answered, which will stimulate future research. However, what became clear is that the nuclear envelope is a cellular structure with critical functions in addition to its traditional role as a barrier separating the nuclear and cytoplasmic compartments in interphase eukaryotic cells.

  11. Envelope proteins of bovine herpesvirus 1: immunological and biochemical studies

    International Nuclear Information System (INIS)

    Rodriguez Roque, L.L.

    1986-01-01

    The authors studied immunological and biochemical properties of the bovid herpesvirus 1 (BHV-1) envelope proteins in order to understand the pathogenesis of BHV-1 infection and to provide basic information for the production of effective subunit vaccines against BHV-1. Ten glycoproteins MW 180, 150, 130, 115, 97, 77, 74, 64, 55, and 45 kilodaltons (K), and a single non-glycosylated 108 K protein were quantitatively removed from purified BHV-1 virions by detergent treatment. These glycoproteins were present on the virion envelope and on the surface of BHV-1 infected cells. The quantitative removal from virions by treatment with nonionic detergents and their presence on the surface of infected cells indicate that 180/97, 150/77, and 130/74/55 K are major components of the BHV-1 envelope and are also the targets of virus neutralizing humoral immune response. Envelope glycoproteins of herpes simplex type 1 (HSV-1) bind immunoglobulin by the Fc end and it is suggested this may increase pathogenicity of this virus. They searched for a similar function in BVH-1 by measuring the ability of BHV-1 infected cells and viral envelope proteins to bind radiolabelled rabbit and bovine IgG. Binding activity for rabbit IgG or bovine IgG-Fc could not be demonstrated by BHV-1 infected MDBK cells, whereas, MDBK cells infected with HSV-1 bound rabbit IgG and bovine IgG-Fc. None of the three major envelope proteins of BHV-1 bound to rabbit or bovine IgG. The results of this study indicate that BHV-1, unlike some other herpesviruses, lack Fc binding activity

  12. Enveloping algebras of Lie groups with descrete series

    International Nuclear Information System (INIS)

    Nguyen huu Anh; Vuong manh Son

    1990-09-01

    In this article we shall prove that the enveloping algebra of the Lie algebra of some unimodular Lie group having discrete series, when localized at some element of the center, is isomorphic to the tensor product of a Weyl algebra over the ring of Laurent polynomials of one variable and the enveloping algebra of some reductive Lie algebra. In particular, it will be proved that the Lie algebra of a unimodular solvable Lie group having discrete series satisfies the Gelfand-Kirillov conjecture. (author). 6 refs

  13. Asymmetry of the envelope of supernova 1987A

    Energy Technology Data Exchange (ETDEWEB)

    Papaliolios, C.; Karovska, M.; Koechlin, L.; Nisenson, P.; Standley, C.; Heathcote, S.

    1989-04-13

    The supernova SN1987A in the Large Magellanic Cloud has been observed by high-angular-resolution speckle interferometry since 25 March (30 days after the explosion) with the 4-m telescope at the Cerro Tololo Interamerican Observatory. Data obtained on 25 March and 2 April 1987 revealed a second bright 'companion' source separated from the supernova by 60 milliarcseconds and less than three magnitudes fainter than the supernova. Measurements of the average diameter of the supernova envelope have been made from data recorded from March 1987 to April 1988. Here we present a more detailed analysis of these data, which shows that the expanding envelope is asymmetric. (author).

  14. Asymmetry of the envelope of supernova 1987A

    International Nuclear Information System (INIS)

    Papaliolios, C.; Karovska, M.; Koechlin, L.; Nisenson, P.; Standley, C.; Heathcote, S.

    1989-01-01

    The supernova SN1987A in the Large Magellanic Cloud has been observed by high-angular-resolution speckle interferometry since 25 March (30 days after the explosion) with the 4-m telescope at the Cerro Tololo Interamerican Observatory. Data obtained on 25 March and 2 April 1987 revealed a second bright 'companion' source separated from the supernova by 60 milliarcseconds and less than three magnitudes fainter than the supernova. Measurements of the average diameter of the supernova envelope have been made from data recorded from March 1987 to April 1988. Here we present a more detailed analysis of these data, which shows that the expanding envelope is asymmetric. (author)

  15. Calculation of CWKB envelope in boson and fermion productions

    International Nuclear Information System (INIS)

    Biswas, S.; Chowdhury, I.

    2007-01-01

    We present the calculation of envelope of boson and of both low-and high-mass fermion production at the end of inflation when the coherently oscillating inflations decay into bosons and fermions. We consider three different models of inflation and use CWKB technique to calculate the envelope to understand the structure of resonance band formation. We observe that though low-mass fermion production is not effective in preheating because of Pauli blocking, it is quite probable for high-mass fermion to take part in pre heating. (author)

  16. Refractive index dispersion measurement using carrier-envelope phasemeters

    International Nuclear Information System (INIS)

    Hansinger, Peter; Töpfer, Philipp; Adolph, Daniel; Hoff, Dominik; Rathje, Tim; Sayler, A Max; Paulus, Gerhard G; Dimitrov, Nikolay; Dreischuh, Alexander

    2017-01-01

    We introduce a novel method for direct and accurate measurement of refractive index dispersion based on carrier-envelope phase detection of few-cycle laser pulses, exploiting the difference between phase and group velocity in a dispersive medium. In a layout similar to an interferometer, two carrier-envelope phasemeters are capable of measuring the dispersion of a transparent or reflective sample, where one phasemeter serves as the reference and the other records the influence of the sample. Here we report on proof-of-principle measurements that already reach relative uncertainties of a few 10 −4 . Further development is expected to allow for unprecedented precision. (paper)

  17. Formation of Planetary Populations I: Metallicity & Envelope Opacity Effects

    Science.gov (United States)

    Alessi, Matthew; Pudritz, Ralph E.

    2018-05-01

    We present a comprehensive body of simulations of the formation of exoplanetary populations that incorporate the role of planet traps in slowing planetary migration. The traps we include in our model are the water ice line, the disk heat transition, and the dead zone outer edge. We reduce our model parameter set to two physical parameters: the opacity of the accreting planetary atmospheres (κenv) and a measure of the efficiency of planetary accretion after gap opening (fmax). We perform planet population synthesis calculations based on the initial observed distributions of host star and disk properties - their disk masses, lifetimes, and stellar metallicities. We find the frequency of giant planet formation scales with disk metallicity, in agreement with the observed Jovian planet frequency-metallicity relation. We consider both X-ray and cosmic ray disk ionization models, whose differing ionization rates lead to different dead zone trap locations. In both cases, Jovian planets form in our model out to 2-3 AU, with a distribution at smaller radii dependent on the disk ionization source and the setting of envelope opacity. We find that low values of κenv (0.001-0.002 cm2 g-1) and X-ray disk ionization are necessary to obtain a separation between hot Jupiters near 0.1 AU, and warm Jupiters outside 0.6 AU, a feature present in the data. Our model also produces a large number of super Earths, but the majority are outside of 2 AU. As our model assumes a constant dust to gas ratio, we suggest that radial dust evolution must be taken into account to reproduce the observed super Earth population.

  18. Pushing the pulverized coal envelope with LEBS

    Energy Technology Data Exchange (ETDEWEB)

    Regan, J.W.; Borio, R.W.; Palkes, M. [and others

    1995-11-01

    In response to challenges from technologies such as IGCC and PFBC, the ABB LEBS Team has proposed removing the barriers to very large advances in environmental and thermal performance of pulverized coal plants. Pulverized coal will continue to be the source of more than half of our electric generation well into the next century and we must develop low-risk low-cost advances that will compete with the claimed performance of other technologies. This paper describes near-term PC technologies for new and retrofit applications which will accomplish this.

  19. Normal Pressure Hydrocephalus (NPH)

    Science.gov (United States)

    ... local chapter Join our online community Normal Pressure Hydrocephalus (NPH) Normal pressure hydrocephalus is a brain disorder ... Symptoms Diagnosis Causes & risks Treatments About Normal Pressure Hydrocephalus Normal pressure hydrocephalus occurs when excess cerebrospinal fluid ...

  20. Predicting the effect of spectral subtraction on the speech recognition threshold based on the signal-to-noise ratio in the envelope domain

    DEFF Research Database (Denmark)

    Jørgensen, Søren; Dau, Torsten

    2011-01-01

    rarely been evaluated perceptually in terms of speech intelligibility. This study analyzed the effects of the spectral subtraction strategy proposed by Berouti at al. [ICASSP 4 (1979), 208-211] on the speech recognition threshold (SRT) obtained with sentences presented in stationary speech-shaped noise....... The SRT was measured in five normal-hearing listeners in six conditions of spectral subtraction. The results showed an increase of the SRT after processing, i.e. a decreased speech intelligibility, in contrast to what is predicted by the Speech Transmission Index (STI). Here, another approach is proposed......, denoted the speech-based envelope power spectrum model (sEPSM) which predicts the intelligibility based on the signal-to-noise ratio in the envelope domain. In contrast to the STI, the sEPSM is sensitive to the increased amount of the noise envelope power as a consequence of the spectral subtraction...

  1. Enveloped virus-like particles as vaccines against pathogenic arboviruses

    NARCIS (Netherlands)

    Pijlman, G.P.

    2015-01-01

    Arthropod-borne arboviruses form a continuous threat to human and animal health, but few arboviral vaccines are currently available. Advances in expression technology for complex, enveloped virus-like particles (eVLPs) create new opportunities to develop potent vaccines against pathogenic

  2. Measuring Eco-efficiency of Production with Data Envelopment Analysis

    NARCIS (Netherlands)

    Kuosmanen, T.K.; Kortelainen, M.

    2005-01-01

    Aggregation of environmental pressures into a single environmental damage index is a major challenge of eco-efficiency measurement. This article examines how the data envelopment analysis (DEA) method can be adapted for this purpose. DEA accounts for substitution possibilities between different

  3. Modeling of heat and mass transfer in lateritic building envelopes

    International Nuclear Information System (INIS)

    Meukam, Pierre

    2004-10-01

    The aim of the present work is to investigate the behavior of building envelopes made of local lateritic soil bricks subjected to different climatic conditions. The analysis is developed for the prediction of the temperature, relative humidity and water content behavior within the walls. The building envelopes studied in this work consist of lateritic soil bricks with incorporation of natural pozzolan or sawdust in order to obtain small thermal conductivity and low-density materials, and limit the heat transfer between the atmospheric climate and the inside environment. In order to describe coupled heat and moisture transfer in wet porous materials, the coupled equations were solved by the introduction of diffusion coefficients. A numerical model HMtrans, developed for prediction of beat and moisture transfer in multi-layered building components, was used to simulate the temperature, water content and relative humidity profiles within the building envelopes. The results allow the prediction of the duration of the exposed building walls to the local weather conditions. They show that for any of three climatic conditions considered, relative humidity and water content do not exceed 87% and 5% respectively. There is therefore minimum possibility of water condensation in the materials studied. The durability of building envelopes made of lateritic soil bricks with incorporation of natural pozzolan or sawdust is not strongly affected by the climatic conditions in tropical and equatorial regions. (author)

  4. Design of a Haptic Feedback System for Flight Envelope Protection

    NARCIS (Netherlands)

    Van Baelen, D.; Ellerbroek, J.; van Paassen, M.M.; Mulder, M.

    2018-01-01

    Current Airbus aircraft use a fly-by-wire control device: a passive spring-damper system which generates, without any force feedback, an electrical signal to the flight control computer. Additionally, a hard flight envelope protection system is used which can limit the inputs of the pilot when

  5. Hygrothermal Simulation: A Tool for Building Envelope Design Analysis

    Science.gov (United States)

    Samuel V. Glass; Anton TenWolde; Samuel L. Zelinka

    2013-01-01

    Is it possible to gauge the risk of moisture problems while designing the building envelope? This article provides a brief introduction to computer-based hygrothermal (heat and moisture) simulation, shows how simulation can be useful as a design tool, and points out a number of im-portant considerations regarding model inputs and limita-tions. Hygrothermal simulation...

  6. Spectral Envelopes and Additive + Residual Analysis/Synthesis

    Science.gov (United States)

    Rodet, Xavier; Schwarz, Diemo

    The subject of this chapter is the estimation, representation, modification, and use of spectral envelopes in the context of sinusoidal-additive-plus-residual analysis/synthesis. A spectral envelope is an amplitude-vs-frequency function, which may be obtained from the envelope of a short-time spectrum (Rodet et al., 1987; Schwarz, 1998). [Precise definitions of such an envelope and short-time spectrum (STS) are given in Section 2.] The additive-plus-residual analysis/synthesis method is based on a representation of signals in terms of a sum of time-varying sinusoids and of a non-sinusoidal residual signal [e.g., see Serra (1989), Laroche et al. (1993), McAulay and Quatieri (1995), and Ding and Qian (1997)]. Many musical sound signals may be described as a combination of a nearly periodic waveform and colored noise. The nearly periodic part of the signal can be viewed as a sum of sinusoidal components, called partials, with time-varying frequency and amplitude. Such sinusoidal components are easily observed on a spectral analysis display (Fig. 5.1) as obtained, for instance, from a discrete Fourier transform.

  7. A model for the sustainable selection of building envelope assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Huedo, Patricia, E-mail: huedo@uji.es [Universitat Jaume I (Spain); Mulet, Elena, E-mail: emulet@uji.es [Universitat Jaume I (Spain); López-Mesa, Belinda, E-mail: belinda@unizar.es [Universidad de Zaragoza (Spain)

    2016-02-15

    The aim of this article is to define an evaluation model for the environmental impacts of building envelopes to support planners in the early phases of materials selection. The model is intended to estimate environmental impacts for different combinations of building envelope assemblies based on scientifically recognised sustainability indicators. These indicators will increase the amount of information that existing catalogues show to support planners in the selection of building assemblies. To define the model, first the environmental indicators were selected based on the specific aims of the intended sustainability assessment. Then, a simplified LCA methodology was developed to estimate the impacts applicable to three types of dwellings considering different envelope assemblies, building orientations and climate zones. This methodology takes into account the manufacturing, installation, maintenance and use phases of the building. Finally, the model was validated and a matrix in Excel was created as implementation of the model. - Highlights: • Method to assess the envelope impacts based on a simplified LCA • To be used at an earlier phase than the existing methods in a simple way. • It assigns a score by means of known sustainability indicators. • It estimates data about the embodied and operating environmental impacts. • It compares the investment costs with the costs of the consumed energy.

  8. CONTROL OF INDOOR ENVIRONMENTS VIA THE REGULATION OF BUILDING ENVELOPES

    Directory of Open Access Journals (Sweden)

    Mitja Košir

    2011-01-01

    Full Text Available The design of comfortable, healthy and stimulating indoor environments in buildings has a direct impact on the users and on energy consumption, as well as on the wider soci-economic environment of society.The indoor environment of buildings is defined with the formulation of the building envelope, which functions as an interface between the internal and external environments and its users. A properly designed, flexible and adequately controlled building envelope is a starting point in the formulation of a high-quality indoor environment. The systematic treatment of the indoor environment and building envelope from a user’s point of view represents an engineering approach that enables the holistic treatment of buildings, as well as integrated components and systems. The presented division of indoor environment in terms of visual, thermal, olfactory, acoustic and ergonomic sub-environments enables the classification and selection of crucial factors influencing design. This selection and classification can be implemented in the design, as well as in control applications of the building envelope. The implementation of the approach described is demonstrated with an example of an automated control system for the internal environment of an office in the building of the Faculty of Civil and Geodetic Engineering.

  9. A model for the sustainable selection of building envelope assemblies

    International Nuclear Information System (INIS)

    Huedo, Patricia; Mulet, Elena; López-Mesa, Belinda

    2016-01-01

    The aim of this article is to define an evaluation model for the environmental impacts of building envelopes to support planners in the early phases of materials selection. The model is intended to estimate environmental impacts for different combinations of building envelope assemblies based on scientifically recognised sustainability indicators. These indicators will increase the amount of information that existing catalogues show to support planners in the selection of building assemblies. To define the model, first the environmental indicators were selected based on the specific aims of the intended sustainability assessment. Then, a simplified LCA methodology was developed to estimate the impacts applicable to three types of dwellings considering different envelope assemblies, building orientations and climate zones. This methodology takes into account the manufacturing, installation, maintenance and use phases of the building. Finally, the model was validated and a matrix in Excel was created as implementation of the model. - Highlights: • Method to assess the envelope impacts based on a simplified LCA • To be used at an earlier phase than the existing methods in a simple way. • It assigns a score by means of known sustainability indicators. • It estimates data about the embodied and operating environmental impacts. • It compares the investment costs with the costs of the consumed energy.

  10. Print and supply of envelopes and file covers

    Indian Academy of Sciences (India)

    “Tender for Supply of Printed Envelopes and File Covers". Tender ... Twenty Five Thousand Only) in the form of Demand Draft drawn on any Nationalized. Bank and .... m) The finalized contract shall be interpreted under Indian Laws. In case of ...

  11. Envelopes of Sets of Measures, Tightness, and Markov Control Processes

    International Nuclear Information System (INIS)

    Gonzalez-Hernandez, J.; Hernandez-Lerma, O.

    1999-01-01

    We introduce upper and lower envelopes for sets of measures on an arbitrary topological space, which are then used to give a tightness criterion. These concepts are applied to show the existence of optimal policies for a class of Markov control processes

  12. Development of a pneumatic roof envelope for industrial greenhouses

    NARCIS (Netherlands)

    Lindner, G.; Vos, de G.J.

    2008-01-01

    The Eindhoven University of Technology (TU/e) was approached by Van Diemen BV, a turn-key greenhouse builder looking for a new and higher insulated design for their green house envelope. They had developed a new system of climate control which rendered windows for ventilation purposes unnecessary

  13. The potential of building envelope greening to achieve quietness

    NARCIS (Netherlands)

    Van Renterghem, T.; Hornikx, M.C.J.; Forssén, J.; Botteldooren, D.

    2013-01-01

    Reduction of noise is one of the multiple benefits of building envelope greening measures. The potential of wall vegetation systems, green roofs, vegetated low screens at roof edges, and also combinations of such treatments, have been studied by means of combining 2D and 3D full-wave numerical

  14. Bioinformatics Analysis of Envelope Glycoprotein E epitopes of ...

    African Journals Online (AJOL)

    The E glycoprotein of dengue virus is responsible for the viral binding to the receptor. The crystal structure of envelope glycoprotein has already been determined. However, where the well-defined Bcell and T-cell epitopes are located is still a question. Because of the large variations among the four dengue genotypes, it is ...

  15. Origin of envelope proteins of a leukemia virus

    International Nuclear Information System (INIS)

    Schneider, R.P.

    1975-01-01

    The roles of avian myeloblastosis virus (AMV) and host myeloblast cells in controlling the protein composition of virus envelope and host cell membrane are being studied by examining an ATPase enzyme in the virus and cells. New culture techniques for virus producing myeloblasts have been developed. (U.S.)

  16. Enveloped virus flocculation and removal in osmolyte solutions.

    Science.gov (United States)

    Gencoglu, Maria F; Heldt, Caryn L

    2015-07-20

    Our ability to reduce infectious disease burden throughout the world has been greatly improved by the creation of vaccines. However, worldwide immunization rates are low. The two most likely reasons are the lack of sufficient distribution in underdeveloped countries and the high cost of vaccine products. The high costs are due to the difficulties of manufacturing individual vaccine products with specialized purification trains. In this study, we propose to use virus flocculation in osmolytes, followed by microfiltration, as an alternative vaccine purification operation. In our previous work, we demonstrated that osmolytes preferentially flocculate a non-enveloped virus, porcine parvovirus (PPV). In this work we show that osmolytes flocculate the enveloped virus, Sindbis virus heat resistant strain (SVHR), and demonstrate a >80% removal with a 0.2 μm microfilter membrane while leaving proteins in solution. The best osmolytes were tested for their ability to flocculate SVHR at different concentrations, pH and ionic strengths. Our best removal was 98% of SVHR in 0.3M mannitol at a pH of 5. We propose that osmolytes are able to flocculate hydrophobic non-enveloped and enveloped virus particles by the reduction of the hydration layer around the particles, which stimulates virus aggregation. Now that we have demonstrated that protecting osmolytes flocculate viruses, this method has the potential to be a future platform purification process for vaccines. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. Masking Release for Sweeping Masker Components with Correlated Envelopes

    DEFF Research Database (Denmark)

    Verhey, Jesko l.; Klein-Hennig, Hendrike; Epp, Bastian

    2013-01-01

    To separate sounds from different sound sources, common properties of natural sounds are used by the auditory system, such as coherent temporal envelope fluctuations and correlated changes of frequency in different frequency regions. The present study investigates how the auditory systemprocesses...

  18. Innovative Danish Building Envelope Components for Passive Houses

    DEFF Research Database (Denmark)

    Tommerup, Henrik M.; Svendsen, Svend

    2006-01-01

    and in some cases very innovative envelope constructions. In this paper, two of the most interesting components are described; a prefabricated light-weight exterior wall element with a load-bearing plywood and steel frame and a foundation / slab on ground solution based on concrete and EPS insulation...

  19. Purification and characterization of cell-envelope proteinase from ...

    African Journals Online (AJOL)

    user

    2012-10-18

    Oct 18, 2012 ... phenylmethylsulfonyl fluoride;. ACE, angiotensin-I-converting enzyme. Poolman, 1998). Cell-envelope proteinase (CEP) play an important role in the lactobacillus proteolytic system. CEPs are the critical enzyme in the system (Kunji et al., 1996), since it is the only enzyme that can initiate the breakdown of.

  20. Selection of the Climate Parameters for a Building Envelopes and Indoor Climate Systems Design

    Directory of Open Access Journals (Sweden)

    Oleg Samarin

    2017-09-01

    Full Text Available The current research considers the principles of selection of the climate information needed for the building envelope and indoor climate design and adopted in Russia and some European countries. Special reference has been made to the shortcoming of methodologies that include the notion of a typical year, and the advantages of climate data sets generated via software-based designs, using pseudo-random number generators. The results of the average temperature of the coldest five-day period with various supplies were calculated using the numerical Monte-Carlo simulations, as well as the current climate data. It has been shown that there is a fundamental overlap between the statistical distribution of temperatures of both instances and the possibility of implementation a probabilistic-statistical method principle in the development of certain climate data, relative to envelopes and thermal conditions of a building. The calculated values were combined with the analytic expression of the normal law of random distribution and the correlations needed for the main parameter selection.

  1. Envelopment filter and K-means for the detection of QRS waveforms in electrocardiogram.

    Science.gov (United States)

    Merino, Manuel; Gómez, Isabel María; Molina, Alberto J

    2015-06-01

    The electrocardiogram (ECG) is a well-established technique for determining the electrical activity of the heart and studying its diseases. One of the most common pieces of information that can be read from the ECG is the heart rate (HR) through the detection of its most prominent feature: the QRS complex. This paper describes an offline version and a real-time implementation of a new algorithm to determine QRS localization in the ECG signal based on its envelopment and K-means clustering algorithm. The envelopment is used to obtain a signal with only QRS complexes, deleting P, T, and U waves and baseline wander. Two moving average filters are applied to smooth data. The K-means algorithm classifies data into QRS and non-QRS. The technique is validated using 22 h of ECG data from five Physionet databases. These databases were arbitrarily selected to analyze different morphologies of QRS complexes: three stored data with cardiac pathologies, and two had data with normal heartbeats. The algorithm has a low computational load, with no decision thresholds. Furthermore, it does not require any additional parameter. Sensitivity, positive prediction and accuracy from results are over 99.7%. Copyright © 2015 IPEM. Published by Elsevier Ltd. All rights reserved.

  2. The psychic envelopes in psychoanalytic theories of infancy.

    Directory of Open Access Journals (Sweden)

    Denis eMellier

    2014-07-01

    Full Text Available This paper aims to review the topic of psychic envelopes and to sketch the main outlines of this concept in infancy. We first explore the origins of the concept in Freud's 'protective shield' and then its development in adult psychoanalysis before going on to see how this fits in infancy with post-Bionian psychoanalysis and development. Four central notions guide this review:1 Freud's protective shield describes a barrier to protect the psychic apparatus against potentially overflowing trauma. It is a core notion which highlights a serious clinical challenge for patients for whom the shield is damaged or faulty: the risk of confusion of borders between the internal/external world, conscious/unconscious, mind/body, or self-conservation/sexuality.2 Anzieu's Skin-Ego is defined by the different senses of the body. The different layers of experienced sensation, of this body-ego, go on to form the psychic envelope. This theory contributes to our understanding of how early trauma, due to the failures of maternal care, can continue to have an impact in adult life. 3 Bick's psychic skin establishes the concept in relation to infancy. The mother’s containing functions allow a first psychic skin to develop, which then defines an infant’s psychic space and affords the infant a degree of self-containment. Houzel then conceptualized this process as a stabilization of drive forces.4 Stern's narrative envelope derives from the intersection between psychoanalysis and neuroscience. It gives us another way to conceptualise the development of pre-verbal communication. It may also pave the way for a finer distinction of different types of envelopes.Ultimately, in this review we find that psychic envelopes in infancy can be viewed from four different perspectives (economic, topographical, dynamic and genetic and recommend further investigation.

  3. Process envelopes for stabilisation/solidification of contaminated soil using lime-slag blend.

    Science.gov (United States)

    Kogbara, Reginald B; Yi, Yaolin; Al-Tabbaa, Abir

    2011-09-01

    Stabilisation/solidification (S/S) has emerged as an efficient and cost-effective technology for the treatment of contaminated soils. However, the performance of S/S-treated soils is governed by several intercorrelated variables, which complicates the optimisation of the treatment process design. Therefore, it is desirable to develop process envelopes, which define the range of operating variables that result in acceptable performance. In this work, process envelopes were developed for S/S treatment of contaminated soil with a blend of hydrated lime (hlime) and ground granulated blast furnace slag (GGBS) as the binder (hlime/GGBS = 1:4). A sand contaminated with a mixture of heavy metals and petroleum hydrocarbons was treated with 5%, 10% and 20% binder dosages, at different water contents. The effectiveness of the treatment was assessed using unconfined compressive strength (UCS), permeability, acid neutralisation capacity and contaminant leachability with pH, at set periods. The UCS values obtained after 28 days of treatment were up to ∼800 kPa, which is quite low, and permeability was ∼10(-8) m/s, which is higher than might be required. However, these values might be acceptable in some scenarios. The binder significantly reduced the leachability of cadmium and nickel. With the 20% dosage, both metals met the waste acceptance criteria for inert waste landfill and relevant environmental quality standards. The results show that greater than 20% dosage would be required to achieve a balance of acceptable mechanical and leaching properties. Overall, the process envelopes for different performance criteria depend on the end-use of the treated material.

  4. Operative air temperature data for different measures applied on a building envelope in warm climate

    Directory of Open Access Journals (Sweden)

    Cristina Baglivo

    2018-04-01

    Full Text Available Several technical combinations have been evaluated in order to design high energy performance buildings for the warm climate. The analysis has been developed in several steps, avoiding the use of HVAC systems.The methodological approach of this study is based on a sequential search technique and it is shown on the paper entitled “Envelope Design Optimization by Thermal Modeling of a Building in a Warm Climate” [1].The Operative Air Temperature trends (TOP, for each combination, have been plotted through a dynamic simulation performed using the software TRNSYS 17 (a transient system simulation program, University of Wisconsin, Solar Energy Laboratory, USA, 2010.Starting from the simplest building configuration consisting of 9 rooms (equal-sized modules of 5 × 5 m2, the different building components are sequentially evaluated until the envelope design is optimized. The aim of this study is to perform a step-by-step simulation, simplifying as much as possible the model without making additional variables that can modify their performances. Walls, slab-on-ground floor, roof, shading and windows are among the simulated building components. The results are shown for each combination and evaluated for Brindisi, a city in southern Italy having 1083 degrees day, belonging to the national climatic zone C. The data show the trends of the TOP for each measure applied in the case study for a total of 17 combinations divided into eight steps.

  5. Bingo! Externally-Supported Performance Intervention for Deficient Visual Search in Normal Aging, Parkinson’s Disease and Alzheimer’s Disease

    Science.gov (United States)

    Laudate, Thomas M.; Neargarder, Sandy; Dunne, Tracy E.; Sullivan, Karen D.; Joshi, Pallavi; Gilmore, Grover C.; Riedel, Tatiana M.; Cronin-Golomb, Alice

    2011-01-01

    External support may improve task performance regardless of an individual’s ability to compensate for cognitive deficits through internally-generated mechanisms. We investigated if performance of a complex, familiar visual search task (the game of bingo) could be enhanced in groups with suboptimal vision by providing external support through manipulation of task stimuli. Participants were 19 younger adults, 14 individuals with probable Alzheimer’s disease (AD), 13 AD-matched healthy adults, 17 non-demented individuals with Parkinson’s disease (PD), and 20 PD-matched healthy adults. We varied stimulus contrast, size, and visual complexity during game play. The externally-supported performance interventions of increased stimulus size and decreased complexity resulted in improvements in performance by all groups. Performance improvement through increased stimulus size and decreased complexity was demonstrated by all groups. AD also obtained benefit from increasing contrast, presumably by compensating for their contrast sensitivity deficit. The general finding of improved performance across healthy and afflicted groups suggests the value of visual support as an easy-to-apply intervention to enhance cognitive performance. PMID:22066941

  6. Architectural Thermal Forms II: Brick Envelope

    DEFF Research Database (Denmark)

    Foged, Isak Worre

    2013-01-01

    The paper presents an architectural concept and design method that investigates the use of dynamic factors in evolutionary form finding processes. The architectural construct, phenotype, is based on a brick assembly and how this can be organized based upon material properties and environmental...... aspects selected from the factors used in the Fanger equations to determine perceived comfort. The work finds that the developed method can be applied as performance oriented driver, while at the same time allowing diversity and variation in the architectural design space....

  7. Folded Plate Structures as Building Envelopes

    DEFF Research Database (Denmark)

    Falk, Andreas; Buelow, Peter von; Kirkegaard, Poul Henning

    2012-01-01

    This paper treats applications of cross-laminated timber (CLT) in structural systems for folded façade solutions. Previous work on CLT-based systems for folded roofs has shown a widening range of structural possibilities to develop timber-based shells. Geometric and material properties play...... CLT-based systems, which are studied and analysed by using a combination of digital tools for structural and environmental design and analysis. The results show gainful, rational properties of folded systems and beneficial effects from an integration of architectural and environmental performance...... criteria in the design of CLT-based façades....

  8. Building envelope for New Buildings and Energy Renovation of Existing Buildings. Project results

    DEFF Research Database (Denmark)

    Rudbeck, Claus Christian; Rose, Jørgen; Esbensen, Peter Kjær

    1999-01-01

    of heat- and moistureflow is insufficiently documented for large insulation thicknesses. Thermal bridges, for instance, plays a larger role for the overall heat loss in these constructions, and moisture in insulation materials will decrease the overall performance of the construction.Due to these facts...... on the following subjects:Scientific basis for calculation programs, Development of calculationsmethods for heat transfer, Development of new building envelope components, Roofing system based on wooden roof elements, Roofing system with drying properties, Moisture uptake and drying from brick constructions...

  9. Event-related brain potentials, bilateral electrodermal activity and Mangina-Test performance in learning disabled/ADHD pre-adolescents with severe behavioral disorders as compared to age-matched normal controls.

    Science.gov (United States)

    Mangina, C A; Beuzeron-Mangina, J H; Grizenko, N

    2000-07-01

    The most frequently encountered developmental problems of learning disabilities/ADHD often co-exist with severe behavioral disorders. As a direct consequence, this condition opens the way to delinquency, school drop-out, depression, suicide, substance abuse, work absenteeism, and other psycho-social complications. In this paper, we are presenting a selective overview of our previous research and its clinical applications in this field as it relates to our present research data pertaining to the effects of our original Memory Workload Paradigm on the event-related brain potentials in differentiating normal and pathological pre-adolescents (learning disabled/ADHD with concomitant severe behavioral disorders such as oppositional and conduct). In addition, it provides data on the bilateral electrodermal activity during cognitive workload and Mangina-Test performance of pathological and normal pre-adolescents conducted in separate sessions. The results of our present research indicate that a significant memory load effect for the P450 latency (F(3,27)=4.98, PWorkload Paradigm in pre-frontal and frontal regions clearly differentiated normal from pathological pre-adolescents (F(1, 18)=12.21, Presearch findings provide an original and valuable demonstration of an integrative and effective clinical psychophysiological application of central (ERPs), autonomic (bilateral electrodermal activity) and neuro-psychometric aspects (Mangina-Test) which characterize normal and pathological pre-adolescents and underpin the neurophysiological basis of learning disabled/ADHD with severe behavioral disorders as opposed to normal subjects.

  10. Expansion of the HMX-1 Flight Envelope With the EDU-5/P Laser Eye Protection Spectacles

    National Research Council Canada - National Science Library

    Penhallegon, William

    2004-01-01

    The purpose of this testing was to determine if the day operations envelope should be expanded to include takeoffs and landings, whether the night operations envelope should he expanded in the VH-6ON...

  11. Patients with primary biliary cholangitis and fatigue present with depressive symptoms and selected cognitive deficits, but with normal attention performance and brain structure.

    Science.gov (United States)

    Zenouzi, Roman; von der Gablentz, Janina; Heldmann, Marcus; Göttlich, Martin; Weiler-Normann, Christina; Sebode, Marcial; Ehlken, Hanno; Hartl, Johannes; Fellbrich, Anja; Siemonsen, Susanne; Schramm, Christoph; Münte, Thomas F; Lohse, Ansgar W

    2018-01-01

    In primary biliary cholangitis (PBC) fatigue is a major clinical challenge of unknown etiology. By demonstrating that fatigue in PBC is associated with an impaired cognitive performance, previous studies have pointed out the possibility of brain abnormalities underlying fatigue in PBC. Whether structural brain changes are present in PBC patients with fatigue, however, is unclear. To evaluate the role of structural brain abnormalities in PBC patients severely affected from fatigue we, therefore, performed a case-control cerebral magnetic resonance imaging (cMRI) study and correlated changes of white and grey brain matter with the cognitive and attention performance. 20 female patients with PBC and 20 female age-matched controls were examined in this study. The assessment of fatigue, psychological symptoms, cognitive and attention performance included clinical questionnaires, established cognition tests and a computerized test battery of attention performance. T1-weighted cMRI and diffusion tensor imaging (DTI) scans were acquired with a 3 Tesla scanner. Structural brain alterations were investigated with voxel-based morphometry (VBM) and DTI analyses. Results were correlated to the cognitive and attention performance. Compared to healthy controls, PBC patients had significantly higher levels of fatigue and associated psychological symptoms. Except for an impairment of verbal fluency, no cognitive or attention deficits were found in the PBC cohort. The VBM and DTI analyses revealed neither major structural brain abnormalities in the PBC cohort nor correlations with the cognitive and attention performance. Despite the high burden of fatigue and selected cognitive deficits, the attention performance of PBC patients appears to be comparable to healthy people. As structural brain alterations do not seem to be present in PBC patients with fatigue, fatigue in PBC must be regarded as purely functional. Future studies should evaluate, whether functional brain changes

  12. Patients with primary biliary cholangitis and fatigue present with depressive symptoms and selected cognitive deficits, but with normal attention performance and brain structure.

    Directory of Open Access Journals (Sweden)

    Roman Zenouzi

    Full Text Available In primary biliary cholangitis (PBC fatigue is a major clinical challenge of unknown etiology. By demonstrating that fatigue in PBC is associated with an impaired cognitive performance, previous studies have pointed out the possibility of brain abnormalities underlying fatigue in PBC. Whether structural brain changes are present in PBC patients with fatigue, however, is unclear. To evaluate the role of structural brain abnormalities in PBC patients severely affected from fatigue we, therefore, performed a case-control cerebral magnetic resonance imaging (cMRI study and correlated changes of white and grey brain matter with the cognitive and attention performance.20 female patients with PBC and 20 female age-matched controls were examined in this study. The assessment of fatigue, psychological symptoms, cognitive and attention performance included clinical questionnaires, established cognition tests and a computerized test battery of attention performance. T1-weighted cMRI and diffusion tensor imaging (DTI scans were acquired with a 3 Tesla scanner. Structural brain alterations were investigated with voxel-based morphometry (VBM and DTI analyses. Results were correlated to the cognitive and attention performance.Compared to healthy controls, PBC patients had significantly higher levels of fatigue and associated psychological symptoms. Except for an impairment of verbal fluency, no cognitive or attention deficits were found in the PBC cohort. The VBM and DTI analyses revealed neither major structural brain abnormalities in the PBC cohort nor correlations with the cognitive and attention performance.Despite the high burden of fatigue and selected cognitive deficits, the attention performance of PBC patients appears to be comparable to healthy people. As structural brain alterations do not seem to be present in PBC patients with fatigue, fatigue in PBC must be regarded as purely functional. Future studies should evaluate, whether functional brain

  13. Normalization: A Preprocessing Stage

    OpenAIRE

    Patro, S. Gopal Krishna; Sahu, Kishore Kumar

    2015-01-01

    As we know that the normalization is a pre-processing stage of any type problem statement. Especially normalization takes important role in the field of soft computing, cloud computing etc. for manipulation of data like scale down or scale up the range of data before it becomes used for further stage. There are so many normalization techniques are there namely Min-Max normalization, Z-score normalization and Decimal scaling normalization. So by referring these normalization techniques we are ...

  14. 78 FR 5148 - Special Conditions: Embraer S.A., Model EMB-550 Airplanes; Flight Envelope Protection: General...

    Science.gov (United States)

    2013-01-24

    ... failure states occur in the electronic flight control system, flight envelope protection features can... Envelope Protection: General Limiting Requirements AGENCY: Federal Aviation Administration (FAA), DOT...), specifically new control architecture and a full digital flight control system which provides flight envelope...

  15. Stability charts for uniform slopes in soils with nonlinear failure envelopes

    OpenAIRE

    Eid, Hisham T.

    2014-01-01

    Based on the results of an extensive parametric study, charts were developed for assessment of the stability of uniform slopes in soils with nonlinear shear strength failure envelopes. The study was conducted using envelopes formed to represent the realistic shapes of soil nonlinear drained strength envelopes and the associated different degrees of nonlinearity. The introduction of a simple methodology to describe the nonlinear envelopes and a stability parameter, the value of which depends o...

  16. Utilising UDT to push the bandwidth envelope

    Science.gov (United States)

    Garrett, B.; Davies, B.

    eScience applications, in particular High Energy Physics, often involve large amounts of data and/or computing and often require secure resource sharing across organizational boundaries, and are thus not easily handled by today's networking infrastructures. By utilising the switched lightpath connections provided by the UKLight network it has been possible to research the use of alternate protocols for data transport. While the HEP projects make use of a number of middleware solutions for data storage and transport, they all rely on GridFTP for WAN transport. The GridFTP protocol runs over TCP as the layer 3 protocol by default, however with the latest released of the Globus toolkit it is possible to utilise alternate protocols at the layer 3 level. One of the alternatives is a reliable version of UDP called UDT. This report presents the results of the tests measuring the performance of single-threaded file transfers using GridFTP running over both TCP and the UDT protocol.

  17. The limits to biocatalysis: pushing the envelope.

    Science.gov (United States)

    Sheldon, Roger A; Brady, Dean

    2018-06-12

    In the period 1985 to 1995 applications of biocatalysis, driven by the need for more sustainable manufacture of chemicals and catalytic, (enantio)selective methods for the synthesis of pharmaceutical intermediates, largely involved the available hydrolases. This was followed, in the next two decades, by revolutionary developments in protein engineering and directed evolution for the optimisation of enzyme function and performance that totally changed the biocatalysis landscape. In the same period, metabolic engineering and synthetic biology revolutionised the use of whole cell biocatalysis in the synthesis of commodity chemicals by fermentation. In particular, developments in the enzymatic enantioselective synthesis of chiral alcohols and amines are highlighted. Progress in enzyme immobilisation facilitated applications under harsh industrial conditions, such as in organic solvents. The emergence of biocatalytic or chemoenzymatic cascade processes, often with co-immobilised enzymes, has enabled telescoping of multi-step processes. Discovering and inventing new biocatalytic processes, based on (meta)genomic sequencing, evolving enzyme promiscuity, chemomimetic biocatalysis, artificial metalloenzymes, and the introduction of non-canonical amino acids into proteins, are pushing back the limits of biocatalysis function. Finally, the integral role of biocatalysis in developing a biobased carbon-neutral economy is discussed.

  18. Dynamical model for the dusty envelope around the symbiotic nova PU Vulpeculae

    International Nuclear Information System (INIS)

    Men'shchikov, A.B.; Tutukov, A.V.; Shustov, B.M.; Ergma, E.V.

    1985-01-01

    An evolutionary model for PU Vul, Object Kuwano--Honda, indicates that the deep 1980--1981 minimum may have resulted from detachment of a dust envelope. The envelope ejection process and the changes in the infrared spectrum are studied numerically; evidently the envelope departs strongly from spherical symmetry. The bluing observed at minimum light might have been due to dissipation of shock energy

  19. PHONOCARDIOGRAM SIGNAL ANALYSIS FOR MURMUR DIAGNOSING USING SHANNON ENERGY ENVELOP AND SEQUENCED DWT DECOMPOSITION

    Directory of Open Access Journals (Sweden)

    MAZIN Z. OTHMAN

    2017-09-01

    Full Text Available This paper presents a proposed procedure to analyze the PCG (Phono-CardioGram signal recorded by an electronic stethoscope. The procedure concludes heart sound cycle segmentation followed by a detecting step to categorize the normal cases from that which are characterized as an abnormal one (mainly Mitral Regurgitation MR and Mitral Stenosis MS. This is achieving using Shannon energy envelop. Furthermore, a diagnosing step is added to recognize the MR and MS cases from other abnormal cases using FFT (Fast Fourier Transform applied to the segmented murmur period. The MR and MS cases were selected since it is the most popular abnormal heart cases recorded in the Middle East countries. The obtained results pleased and agreed many cardiac specialists. The MATLAB is the main software environment used in this work.

  20. Performance of non-neurological older adults on the Wisconsin Card Sorting Test and the Stroop Color-Word Test: normal variability or cognitive impairment?

    Science.gov (United States)

    Gunner, Jessica H; Miele, Andrea S; Lynch, Julie K; McCaffrey, Robert J

    2012-06-01

    There is currently no standard criterion for determining abnormal test scores in neuropsychology; thus, a number of different criteria are commonly used. We investigated base rates of abnormal scores in healthy older adults using raw and T-scores from indices of the Wisconsin Card Sorting Test and Stroop Color-Word Test. Abnormal scores were examined cumulatively at seven cutoffs including >1.0, >1.5, >2.0, >2.5, and >3.0 standard deviations (SD) from the mean as well as those below the 10th and 5th percentiles. In addition, the number of abnormal scores at each of the seven cutoffs was also examined. Results showed when considering raw scores, ∼15% of individuals obtained scores>1.0 SD from the mean, around 10% were less than the 10th percentile, and 5% fell >1.5 SD or 1.0 and >1.5 SD from the mean, respectively. Roughly 15% and 5% fell at the 2.0 SD from the mean were infrequent. Although the presence of a single abnormal score at 1.0 and 1.5 SD from the mean or at the 10th and 5th percentiles was not unusual, the presence of ≥2 abnormal scores using any criteria was uncommon. Consideration of base rate data regarding the percentage of healthy individuals scoring in the abnormal range should help avoid classifying normal variability as neuropsychological impairment.

  1. GAGE cancer-germline antigens bind DNA and are recruited to the nuclear envelope by Germ cell-less

    DEFF Research Database (Denmark)

    Gjerstorff, Morten; Rösner, Heike; Pedersen, Christina Bøg

    GAGE genes encode a highly similar, primate-specific protein family with unique primary structure and undefined roles in germ cells, various fetal cells and cancer cells. We report that GAGE proteins are intrinsically disordered proteins that provide novel interfaces between chromatin and the nuc......GAGE genes encode a highly similar, primate-specific protein family with unique primary structure and undefined roles in germ cells, various fetal cells and cancer cells. We report that GAGE proteins are intrinsically disordered proteins that provide novel interfaces between chromatin...... and the nuclear envelope. Structural analysis by NMR and CD spectroscopy showed GAGE proteins lack distinct secondary or tertiary structure and are therefore intrinsically disordered. In normal cells and cancer cells GAGE proteins localize predominantly in the nucleus; we found GAGE proteins formed stable......) at the nuclear envelope. Furthermore, exogenous and endogenous GAGE proteins were recruited to the nuclear envelope in GCL-overexpressing cells. Gene expression analysis and immunohistochemical staining suggest GAGE proteins and GCL interact physiologically in human cells that express both, including male germ...

  2. Serial femtosecond X-ray diffraction of enveloped virus microcrystals

    Directory of Open Access Journals (Sweden)

    Robert M. Lawrence

    2015-07-01

    Full Text Available Serial femtosecond crystallography (SFX using X-ray free-electron lasers has produced high-resolution, room temperature, time-resolved protein structures. We report preliminary SFX of Sindbis virus, an enveloped icosahedral RNA virus with ∼700 Å diameter. Microcrystals delivered in viscous agarose medium diffracted to ∼40 Å resolution. Small-angle diffuse X-ray scattering overlaid Bragg peaks and analysis suggests this results from molecular transforms of individual particles. Viral proteins undergo structural changes during entry and infection, which could, in principle, be studied with SFX. This is an important step toward determining room temperature structures from virus microcrystals that may enable time-resolved studies of enveloped viruses.

  3. Virulence properties of the Legionella pneumophila cell envelope

    Directory of Open Access Journals (Sweden)

    Olga eShevchuk

    2011-04-01

    Full Text Available The bacterial envelope plays a crucial role in the pathogenesis of infectious diseases. In this review, we summarize the current knowledge of the structure and molecular composition of the Legionella pneumophila cell envelope. We describe LPS biosynthesis and the biological activities of membrane and periplasmic proteins and discuss their decisive functions during the pathogen-host interaction. In addition to adherence, invasion and intracellular survival of L. pneumophila, special emphasis is laid on iron acquisition, detoxification, key elicitors of the immune response and the diverse functions of outer membrane vesicles. The critical analysis of the literature reveals that the dynamics and phenotypic plasticity of the Legionella cell surface during the different metabolic stages requires more attention in the future.

  4. Maximum Torque and Momentum Envelopes for Reaction Wheel Arrays

    Science.gov (United States)

    Markley, F. Landis; Reynolds, Reid G.; Liu, Frank X.; Lebsock, Kenneth L.

    2009-01-01

    Spacecraft reaction wheel maneuvers are limited by the maximum torque and/or angular momentum that the wheels can provide. For an n-wheel configuration, the torque or momentum envelope can be obtained by projecting the n-dimensional hypercube, representing the domain boundary of individual wheel torques or momenta, into three dimensional space via the 3xn matrix of wheel axes. In this paper, the properties of the projected hypercube are discussed, and algorithms are proposed for determining this maximal torque or momentum envelope for general wheel configurations. Practical strategies for distributing a prescribed torque or momentum among the n wheels are presented, with special emphasis on configurations of four, five, and six wheels.

  5. Functional envelope of a non-autonomous discrete system

    Directory of Open Access Journals (Sweden)

    Barzanouni Ali

    2017-11-01

    Full Text Available Let (X, F = {fn}n =0∞ be a non-autonomous discrete system by a compact metric space X and continuous maps fn : X → X, n = 0, 1, ....We introduce functional envelope (S(X, G = {Gn}n =0∞, of (X, F = {fn}n =0∞, where S(X is the space of all continuous self maps of X and the map Gn : S(X → S(X is defined by Gn(ϕ = Fn ∘ ϕ, Fn = fn ∘ fn-1 ∘ . . . ∘ f1 ∘ f0. The paper mainly deals with the connection between the properties of a system and the properties of its functional envelope.

  6. Efficiency in the Worst Production Situation Using Data Envelopment Analysis

    Directory of Open Access Journals (Sweden)

    Md. Kamrul Hossain

    2013-01-01

    Full Text Available Data envelopment analysis (DEA measures relative efficiency among the decision making units (DMU without considering noise in data. The least efficient DMU indicates that it is in the worst situation. In this paper, we measure efficiency of individual DMU whenever it losses the maximum output, and the efficiency of other DMUs is measured in the observed situation. This efficiency is the minimum efficiency of a DMU. The concept of stochastic data envelopment analysis (SDEA is a DEA method which considers the noise in data which is proposed in this study. Using bounded Pareto distribution, we estimate the DEA efficiency from efficiency interval. Small value of shape parameter can estimate the efficiency more accurately using the Pareto distribution. Rank correlations were estimated between observed efficiencies and minimum efficiency as well as between observed and estimated efficiency. The correlations are indicating the effectiveness of this SDEA model.

  7. A deformation (strain) envelope for cyclic disturbed sand

    DEFF Research Database (Denmark)

    Sabaliauskas, Tomas; Ibsen, Lars Bo

    2018-01-01

    Recent advances in triaxial testing procedures revealed new properties governing disturbed sand stiffness. This paper summarizes the new observations into an original, proof of concept. The novel concept interpolates effective stress within a strain (deformation) envelope. Coulomb stress limits...... are still satisfied, but the stresses are interpolated using a deformation (strain) envelope. The method is not part of a constitutive formulation, but is remarkably functional in triaxial testing practice. The practicality is proven by plotting simulations on top of empirically measured stiffness history...... - the fitting is remarkably good even during tests of extreme complexity. The novelty has substantial interdisciplinary potential: offshore anchors and foundations, earthquakes and industrial processes - wherever dynamic loads and disturbed sand are encountered. It opens the door to a new branch of numerical...

  8. Enveloped Lives: Practicing Health and Care in Lithuania.

    Science.gov (United States)

    Praspaliauskiene, Rima

    2016-12-01

    This article analyzes informal medical payments that the majority of Lithuanians give or feel compelled to give to doctors before or after treatment. It focuses on how patients and their caretakers encounter, practice, and enact informal payments in health care and how these payments create a reality of health care that is not limited to an economic rationality. Within such a frame, rather than being considered a gift or bribe, it conceptualizes these little white envelopes as a practice of health and care. The article shows how an envelope of money given to a doctor transcends the material patient-doctor transaction and emerges as a productive force for coping with illness, medical encounters, and misfortunes. © 2016 by the American Anthropological Association.

  9. Clinical use of ultrashort-lived radionuclide krypton-81m for noninvasive analysis of right ventricular performance in normal subjects and patients with right ventricular dysfunction

    International Nuclear Information System (INIS)

    Nienaber, C.A.; Spielmann, R.P.; Wasmus, G.; Mathey, D.G.; Montz, R.; Bleifeld, W.H.

    1985-01-01

    The ultrashort-lived radionuclide krypton-81m, eluted in 5% dextrose from a bedside rubidium-81m generator, was intravenously infused for rapid imaging of the right-sided heart chambers in the right anterior oblique projection adjusted for optimal right atrioventricular separation. Left-sided heart and lung background was minimized by rapid decay and efficient exhalation of krypton-81m, requiring no algorithm for background correction. A double region of interest method decreased the variability in the assessment of ejection fraction to 5%. In 10 normal subjects, 11 patients with pulmonary hypertension, 4 patients with right ventricular outflow tract obstruction and 4 patients with right ventricular infarction, right ventricular ejection fraction determined by krypton-81m equilibrium blood pool imaging ranged from 14 to 76%. The correlation between these values and those determined by cineangiography according to Simpson's rule was close: r . 0.93 for all data points, r . 0.92 for studies at rest and r . 0.93 for exercise studies. Exercise-related changes in right ventricular function revealed a disturbed functional reserve with pulmonary hypertension and right ventricular infarction, whereas in compensated right ventricular outflow tract obstruction there was a physiologic increase in ejection fraction with exercise. Thus, equilibrium-gated right ventricular imaging using ultrashort-lived krypton-81m is a simple, accurate and reproducible method with potential for serial assessment of right ventricular ejection fraction in a variety of right ventricular anatomic and functional abnormalities, both at rest and during exercise. Advantages of this method include an extremely low radiation dose to patients and clear right atrioventricular separation without the need to correct for background activity

  10. ASTM Committee C28: International Standards for Properties and Performance of Advanced Ceramics-Three Decades of High-Quality, Technically-Rigorous Normalization

    Science.gov (United States)

    Jenkins, Michael G.; Salem, Jonathan A.

    2016-01-01

    Physical and mechanical properties and performance of advanced ceramics and glasses are difficult to measure correctly without the proper techniques. For over three decades, ASTM Committee C28 on Advanced Ceramics, has developed high-quality, technically-rigorous, full-consensus standards (e.g., test methods, practices, guides, terminology) to measure properties and performance of monolithic and composite ceramics that may be applied to glasses in some cases. These standards contain testing particulars for many mechanical, physical, thermal, properties and performance of these materials. As a result these standards are used to generate accurate, reliable, repeatable and complete data. Within Committee C28, users, producers, researchers, designers, academicians, etc. have written, continually updated, and validated through round-robin test programs, 50 standards since the Committee's founding in 1986. This paper provides a detailed retrospective of the 30 years of ASTM Committee C28 including a graphical pictogram listing of C28 standards along with examples of the tangible benefits of standards for advanced ceramics to demonstrate their practical applications.

  11. ASTM Committee C28: International Standards for Properties and Performance of Advanced Ceramics, Three Decades of High-quality, Technically-rigorous Normalization

    Science.gov (United States)

    Jenkins, Michael G.; Salem, Jonathan A.

    2016-01-01

    Physical and mechanical properties and performance of advanced ceramics and glasses are difficult to measure correctly without the proper techniques. For over three decades, ASTM Committee C28 on Advanced Ceramics, has developed high quality, rigorous, full-consensus standards (e.g., test methods, practices, guides, terminology) to measure properties and performance of monolithic and composite ceramics that may be applied to glasses in some cases. These standards testing particulars for many mechanical, physical, thermal, properties and performance of these materials. As a result these standards provide accurate, reliable, repeatable and complete data. Within Committee C28 users, producers, researchers, designers, academicians, etc. have written, continually updated, and validated through round-robin test programs, nearly 50 standards since the Committees founding in 1986. This paper provides a retrospective review of the 30 years of ASTM Committee C28 including a graphical pictogram listing of C28 standards along with examples of the tangible benefits of advanced ceramics standards to demonstrate their practical applications.

  12. The psychic envelopes in psychoanalytic theories of infancy

    Science.gov (United States)

    Mellier, Denis

    2014-01-01

    This paper aims to review the topic of psychic envelopes and to sketch the main outlines of this concept in infancy. We first explore the origins of the concept in Freud's “protective shield” and then its development in adult psychoanalysis before going on to see how this fits in infancy with post-Bionian psychoanalysis and development. Four central notions guide this review: (1) Freud's “protective shield” describes a barrier to protect the psychic apparatus against potentially overflowing trauma. It is a core notion which highlights a serious clinical challenge for patients for whom the shield is damaged or faulty: the risk of confusion of borders between the internal/external world, conscious/unconscious, mind/body, or self-conservation/sexuality. (2) Anzieu's “Skin-Ego” is defined by the different senses of the body. The different layers of experienced sensation, of this body-ego, go on to form the psychic envelope. This theory contributes to our understanding of how early trauma, due to the failures of maternal care, can continue to have an impact in adult life. (3) Bick's “psychic skin” establishes the concept in relation to infancy. The mother's containing functions allow a first psychic skin to develop, which then defines an infant's psychic space and affords the infant a degree of self-containment. Houzel then conceptualized this process as a stabilization of drive forces. (4) Stern's “narrative envelope” derives from the intersection between psychoanalysis and neuroscience. It gives us another way to conceptualize the development of pre-verbal communication. It may also pave the way for a finer distinction of different types of envelopes. Ultimately, in this review we find that psychic envelopes in infancy can be viewed from four different perspectives (economic, topographical, dynamic, and genetic) and recommend further investigation. PMID:25076924

  13. Maximum Likelihood, Consistency and Data Envelopment Analysis: A Statistical Foundation

    OpenAIRE

    Rajiv D. Banker

    1993-01-01

    This paper provides a formal statistical basis for the efficiency evaluation techniques of data envelopment analysis (DEA). DEA estimators of the best practice monotone increasing and concave production function are shown to be also maximum likelihood estimators if the deviation of actual output from the efficient output is regarded as a stochastic variable with a monotone decreasing probability density function. While the best practice frontier estimator is biased below the theoretical front...

  14. The Use of Categorical Variables in Data Envelopment Analysis

    OpenAIRE

    Rajiv D. Banker; Richard C. Morey

    1986-01-01

    Data Envelopment Analysis has now been extensively applied in a range of empirical settings to identify relative inefficiencies, and provide targets for improvements. It accomplishes this by developing peer groups for each unit being operated. The use of categorical variables is an important extension which can improve the peer group construction process and incorporate "on-off" characteristics, e.g., presence of drive-in window or not in a banking network. It relaxes the stringent need for f...

  15. Windows and Envelope R&D Opportunities Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Building Technologies Office

    2018-02-01

    BTO's Emerging Technologies program held a two-day workshop on “Windows and Envelope R&D Opportunities” on May 31 and June 1, 2017 at the Illinois Institute of Technology in Chicago, Illinois. A broad range of about 100 experts from industry, academia, national laboratories, and government participated, contributing their ideas, insights, and perspectives. Their feedback is intended to help inform and augment BTO’s research and development activities.

  16. Solitons of an envelope in an inhomogeneous medium

    International Nuclear Information System (INIS)

    Churilov, S.M.

    1982-01-01

    Solutions of the Schroedinger nonlinear equation (SNE) used for the description of evolution of a wave packet envelope has been investigated in inhomogeneous and nonstationary media. It is shown that the SNE solution possessing two important properties exists. Firstly, the wave packet remains localized when propagating in an inhomogeneous medium. Secondly, the soliton width and amplitude are determined only with local characteristics of medium and don't depend on the prehistory. Problem of limits of obtained result applicability has been considered

  17. Biomimetic Architecture in Building Envelope Maintenance (A Literature

    Directory of Open Access Journals (Sweden)

    Agus Salim N.A.

    2014-01-01

    Full Text Available The study of biomimetic architecture on building envelope is the main structure of this research. The concept is believed more sustainable and efficient for energy saving, operating cost consumption, waste recycle and design renewal in the future. The inspiration from the nature developed the intention on this study to explore on what and how this concept to overcome the problems through design. Biomimicry does catch the attention of human to study more on the system and function of its nature course. The designers are not exception influenced by this concept when the form, shape, texture and colour inspired them in their design. The domination of building form will affect the building envelope as the skin of the structure. A clear impact on building failure is begun with building envelope appearance without a proper maintenance. The faults in building design place a heavy burden on the building for the rest of its operational life and there is no compensation for it. In such situations, the responsibility falls on the shoulders of the designer.

  18. Specifics of Building Envelope Air Leakage Problems and Airtightness Measurements

    Directory of Open Access Journals (Sweden)

    Borodinecs Anatolijs

    2016-01-01

    Full Text Available In addition to transmission heat loses the infiltration of outdoor air can cause significant heat losses. The external building envelope should be airtight in order to prevent uncontrolled cold air infiltration. The article analysis modern building materials and structures influence on airtightness. The practical measurements of renovated buildings’ airtightness are presented and compared to non-renovated buildings. In addition paper presents data on airtightness measurements of whole multi apartment building and single apartment in analyzed building taking inco accout properties of building materials. The airtightness of single apartment was evaluated with support pressure in neighbor apartments. The results show that the airtightness measurements of multi apartment building can be evaluated by measuring single apartment on last floor with support pressure in neighbor apartments. The practical measurement of renovated buildings had shown the air leakage rate q50 of typical Latvian construction after renovation is between 2.5 and 2.9 m3/(m2·h. Since the building envelope has to minimize the heat loses (transmission and infiltration and ventilation system either mechanical or natural has to provide necessary air exchange, the building envelope airtightness shouldn’t be dependent on type of ventilation systems.

  19. The epigenetics of nuclear envelope organization and disease

    International Nuclear Information System (INIS)

    Schirmer, Eric C.

    2008-01-01

    Mammalian chromosomes and some specific genes have non-random positions within the nucleus that are tissue-specific and heritable. Work in many organisms has shown that genes at the nuclear periphery tend to be inactive and altering their partitioning to the interior results in their activation. Proteins of the nuclear envelope can recruit chromatin with specific epigenetic marks and can also recruit silencing factors that add new epigenetic modifications to chromatin sequestered at the periphery. Together these findings indicate that the nuclear envelope is a significant epigenetic regulator. The importance of this function is emphasized by observations of aberrant distribution of peripheral heterochromatin in several human diseases linked to mutations in NE proteins. These debilitating inherited diseases range from muscular dystrophies to the premature aging progeroid syndromes and the heterochromatin changes are just one early clue for understanding the molecular details of how they work. The architecture of the nuclear envelope provides a unique environment for epigenetic regulation and as such a great deal of research will be required before we can ascertain the full range of its contributions to epigenetics

  20. Dynamics of Preferential Substrate Recognition in HIV-1 Protease: Redefining the Substrate Envelope

    Science.gov (United States)

    Özen, Ayşegül; Haliloğlu, Türkan; Schiffer, Celia A.

    2011-01-01

    HIV-1 protease (PR) permits viral maturation by processing the Gag and Gag-Pro-Pol polyproteins. Though HIV-1 PR inhibitors (PIs) are used in combination antiviral therapy, the emergence of drug resistance has limited their efficacy. The rapid evolution of HIV-1 necessitates the consideration of drug resistance in novel drug-design strategies. Drug-resistant HIV-1 PR variants, while no longer efficiently inhibited, continue to efficiently hydrolyze the natural viral substrates. Though highly diverse in sequence, the HIV-1 PR substrates bind in a conserved three-dimensional shape we defined as the “substrate envelope”. We previously showed that resistance mutations arise where PIs protrude beyond the substrate envelope, as these regions are crucial for drug binding but not for substrate recognition. Here, we extend this model by considering the role of protein dynamics in the interaction of HIV-1 PR with its substrates. Seven molecular dynamics simulations of PR-substrate complexes were performed to estimate the conformational flexibility of substrates in their complexes. Interdependency of the substrate-protease interactions may compensate for the variations in cleavage-site sequences, and explain how a diverse set of sequences can be recognized as substrates by the same enzyme. This diversity may be essential for regulating sequential processing of substrates. We also define a dynamic substrate envelope as a more accurate representation of PR-substrate interactions. This dynamic substrate envelope, described by a probability distribution function, is a powerful tool for drug design efforts targeting ensembles of resistant HIV-1 PR variants with the aim of developing drugs that are less susceptible to resistance. PMID:21762811

  1. Cognitive psychopathology in Schizophrenia: Comparing memory performances with Obsessive-compulsive disorder patients and normal subjects on the Wechsler Memory Scale-IV.

    Science.gov (United States)

    Cammisuli, Davide Maria; Sportiello, Marco Timpano

    2016-06-01

    Memory system turns out to be one of the cognitive domains most severely impaired in schizophrenia. Within the theoretical framework of cognitive psychopathology, we compared the performance of schizophrenia patients on the Wechsler Memory Scale-IV with that in matched patients with Obsessive-compulsive disorder and that in healthy control subjects to establish the specific nature of memory deficits in schizophrenia. 30 schizophrenia patients, 30 obsessive-compulsive disorder patients and 40 healthy controls completed the Wechsler Memory Scale-IV. Schizophrenia symptom severity was assessed by the Positive and Negative Syndrome Scale (PANSS). Performances on memory battery including Indexes and subtests scores were compared by a One-Way ANOVA (Scheffé post-hoc test). Spearman Rank correlations were performed between scores on PANSS subscales and symptoms and WMS-IV Indexes and subtests, respectively. Schizophrenia patients showed a memory profile characterized by mild difficulties in auditory memory and visual working memory and poor functioning of visual, immediate and delayed memory. As expected, schizophrenia patients scored lower than healthy controls on all WMS-IV measures. With regard to the WMS-IV Indexes, schizophrenia patients performed worse on Auditory Memory, Visual Memory, Immediate and Delayed Memory than Obsessive-compulsive disorder patients but not on Visual Working Memory. Such a pattern was made even clearer for specific tasks such as immediate and delayed recall and spatial recall and memory for visual details, as revealed by the lowest scores on Logical Memory (immediate and delayed conditions) and Designs (immediate condition) subtests, respectively. Significant negative correlations between Logical Memory I and II were found with PANSS Excitement symptom as well as between DE I and PANSS Tension symptom. Significant positive correlations between LM II and PANSS Blunted affect and Poor rapport symptoms as well as DE I and PANSS Blunted affect

  2. A technique for performing electrical impedance myography in the mouse hind limb: data in normal and ALS SOD1 G93A animals.

    Directory of Open Access Journals (Sweden)

    Jia Li

    Full Text Available To test a method for performing electrical impedance myography (EIM in the mouse hind limb for the assessment of disease status in neuromuscular disease models.An impedance measuring device consisting of a frame with electrodes embedded within an acrylic head was developed. The head was rotatable such that data longitudinal and transverse to the major muscle fiber direction could be obtained. EIM measurements were made with this device on 16 healthy mice and 14 amyotrophic lateral sclerosis (ALS animals. Repeatability was assessed in both groups.The technique was easy to perform and provided good repeatability in both healthy and ALS animals, with intra-session repeatability (mean ± SEM of 5% ± 1% and 12% ± 2%, respectively. Significant differences between healthy and ALS animals were also identified (e.g., longitudinal mean 50 kHz phase was 18 ± 0.6° for the healthy animals and 14 ± 1.0° for the ALS animals, p=0.0025.With this simple device, the EIM data obtained is highly repeatable and can differentiate healthy from ALS animals.EIM can now be applied to mouse models of neuromuscular disease to assess disease status and the effects of therapy.

  3. Dietary sugarcane bagasse and coarse particle size of corn are beneficial to performance and gizzard development in broilers fed normal and high sodium diets.

    Science.gov (United States)

    Kheravii, S K; Swick, R A; Choct, M; Wu, Shu-Biao

    2017-09-01

    An experiment was conducted to evaluate the effects of sugarcane bagasse (SB) and particle size on broiler performance, gizzard development, ileal microflora, litter quality, and bird welfare under a wet litter challenge model. A total of 672 one-day-old Ross 308 male broilers was allocated to 48 pens using a 2 × 2 × 2 factorial arrangement of treatments with corn particle size-coarse 3,576 μm (CC) or fine 1,113 μm (FC) geometric mean diameter, SB - 0 or 2% and sodium (Na) - 0.16 or 0.40% with increased Na level to induce wet litter. A 3-way particle size × Na × SB interaction (P litter quality and bird welfare were observed, but higher Na increased litter moisture and footpad dermatitis (FPD) scores (P < 0.001). These findings suggest that SB independently or in combination with CC improves performance in older birds regardless of Na level in diets, possibly through improved gizzard development and gut microflora of birds. © 2017 Poultry Science Association Inc.

  4. Emergy-Based Regional Socio-Economic Metabolism Analysis: An Application of Data Envelopment Analysis and Decomposition Analysis

    OpenAIRE

    Zilong Zhang; Xingpeng Chen; Peter Heck

    2014-01-01

    Integrated analysis on socio-economic metabolism could provide a basis for understanding and optimizing regional sustainability. The paper conducted socio-economic metabolism analysis by means of the emergy accounting method coupled with data envelopment analysis and decomposition analysis techniques to assess the sustainability of Qingyang city and its eight sub-region system, as well as to identify the major driving factors of performance change during 2000–2007, to serve as the basis for f...

  5. Low-cost phase change material as an energy storage medium in building envelopes: Experimental and numerical analyses

    International Nuclear Information System (INIS)

    Biswas, Kaushik; Abhari, Ramin

    2014-01-01

    Highlights: • Testing of a low-cost bio-PCM in an exterior wall under varying weather conditions. • Numerical model validation and annual simulations of PCM-enhanced cellulose insulation. • Reduced wall-generated cooling electricity consumption due to the application of PCM. • PCM performance was sensitive to its location and distribution within the wall. - Abstract: A promising approach to increasing the energy efficiency of buildings is the implementation of a phase change material (PCM) in the building envelope. Numerous studies over the last two decades have reported the energy saving potential of PCMs in building envelopes, but their wide application has been inhibited, in part, by their high cost. This article describes a novel PCM made of naturally occurring fatty acids/glycerides trapped into high density polyethylene (HDPE) pellets and its performance in a building envelope application. The PCM–HDPE pellets were mixed with cellulose insulation and then added to an exterior wall of a test building in a hot and humid climate, and tested over a period of several months. To demonstrate the efficacy of the PCM-enhanced cellulose insulation in reducing the building envelope heat gains and losses, a side-by-side comparison was performed with another wall section filled with cellulose-only insulation. Further, numerical modeling of the test wall was performed to determine the actual impact of the PCM–HDPE pellets on wall-generated heating and cooling loads and the associated electricity consumption. The model was first validated using experimental data and then used for annual simulations using typical meteorological year (TMY3) weather data. This article presents the experimental data and numerical analyses showing the energy-saving potential of the new PCM

  6. High pressure treatment under subfreezing temperature results in drastic inactivation of enveloped and non-enveloped viruses.

    Science.gov (United States)

    Kishida, T; Cui, F-D; Ohgitani, E; Gao, F; Hayakawa, K; Mazda, O

    2013-08-01

    Some viruses are sensitive to high pressure. The freeze-pressure generation method (FPGM) applies pressure as high as 250 MPa on a substance, simply by freezing a pressure-resistant reservoir in which the substance is immersed in water. Here we examined whether the FPGM successfully inactivates herpes simplex virus type 1 (HSV-1), an enveloped DNA virus belonging to the human Herpesviridae, and encephalomyocarditis virus (EMCV), an envelope-free RNA virus belonging to the Picornaviridae. After the treatment, HSV-1 drastically reduced the ability to form plaque in Vero cells in vitro as well as to kill mice in vivo. EMCV that had been pressurized failed to proliferate in HeLa cells and induce interferon response. The results suggest that the FPGM provides a feasible procedure to inactivate a broad spectrum of viruses.

  7. Rapid Process to Generate Beam Envelopes for Optical System Analysis

    Science.gov (United States)

    Howard, Joseph; Seals, Lenward

    2012-01-01

    The task of evaluating obstructions in the optical throughput of an optical system requires the use of two disciplines, and hence, two models: optical models for the details of optical propagation, and mechanical models for determining the actual structure that exists in the optical system. Previous analysis methods for creating beam envelopes (or cones of light) for use in this obstruction analysis were found to be cumbersome to calculate and take significant time and resources to complete. A new process was developed that takes less time to complete beam envelope analysis, is more accurate and less dependent upon manual node tracking to create the beam envelopes, and eases the burden on the mechanical CAD (computer-aided design) designers to form the beam solids. This algorithm allows rapid generation of beam envelopes for optical system obstruction analysis. Ray trace information is taken from optical design software and used to generate CAD objects that represent the boundary of the beam envelopes for detailed analysis in mechanical CAD software. Matlab is used to call ray trace data from the optical model for all fields and entrance pupil points of interest. These are chosen to be the edge of each space, so that these rays produce the bounding volume for the beam. The x and y global coordinate data is collected on the surface planes of interest, typically an image of the field and entrance pupil internal of the optical system. This x and y coordinate data is then evaluated using a convex hull algorithm, which removes any internal points, which are unnecessary to produce the bounding volume of interest. At this point, tolerances can be applied to expand the size of either the field or aperture, depending on the allocations. Once this minimum set of coordinates on the pupil and field is obtained, a new set of rays is generated between the field plane and aperture plane (or vice-versa). These rays are then evaluated at planes between the aperture and field, at a

  8. Role of HIV-2 envelope in Lv2-mediated restriction

    International Nuclear Information System (INIS)

    Reuter, Sandra; Kaumanns, Patrick; Buschhorn, Sabine B.; Dittmar, Matthias T.

    2005-01-01

    We have characterized envelope protein pseudotyped HIV-2 particles derived from two HIV-2 isolates termed prCBL23 and CBL23 in order to define the role of the envelope protein for the Lv2-mediated restriction to infection. Previously, it has been described that the primary isolate prCBL23 is restricted to infection of several human cell types, whereas the T cell line adapted isolate CBL23 is not restricted in these cell types. Molecular cloning of the two isolates revealed that the env and the gag gene are responsible for the observed phenotype and that this restriction is mediated by Lv2, which is distinct from Ref1/Lv1 (Schmitz, C., Marchant, D., Neil, S.J., Aubin, K., Reuter, S., Dittmar, M.T., McKnight, A., Kizhatil, K., Albritton, L.M., 2004. Lv2, a novel postentry restriction, is mediated by both capsid and envelope. J. Virol. 78 (4), 2006-2016). We generated pseudotyped viruses consisting of HIV-2 (ROD-AΔenv-GFP, ROD-AΔenv-RFP, or ROD-AΔenv-REN) and the prCBL23 or CBL23 envelope proteins as well as chimeric proteins between these envelopes. We demonstrate that a single amino acid exchange at position 74 in the surface unit of CBL23-Env confers restriction to infection. This single point mutation causes tighter CD4 binding, resulting in a less efficient fusion into the cytosol of the restricted cell line. Prevention of endosome formation and prevention of endosome acidification enhance infectivity of the restricted particles for GHOST/X4 cells indicating a degradative lysosomal pathway as a cause for the reduced cytosolic entry. The described restriction to infection of the primary isolate prCBL23 is therefore largely caused by an entry defect. A remaining restriction to infection (19-fold) is preserved when endosomal acidification is prevented. This restriction to infection is also dependent on the presence of the point mutation at position 74 (G74E)

  9. A targeted mutation within the feline leukemia virus (FeLV) envelope protein immunosuppressive domain to improve a canarypox virus-vectored FeLV vaccine.

    Science.gov (United States)

    Schlecht-Louf, Géraldine; Mangeney, Marianne; El-Garch, Hanane; Lacombe, Valérie; Poulet, Hervé; Heidmann, Thierry

    2014-01-01

    We previously delineated a highly conserved immunosuppressive (IS) domain within murine and primate retroviral envelope proteins that is critical for virus propagation in vivo. The envelope-mediated immunosuppression was assessed by the ability of the proteins, when expressed by allogeneic tumor cells normally rejected by engrafted mice, to allow these cells to escape, at least transiently, immune rejection. Using this approach, we identified key residues whose mutation (i) specifically abolishes immunosuppressive activity without affecting the "mechanical" function of the envelope protein and (ii) significantly enhances humoral and cellular immune responses elicited against the virus. The objective of this work was to study the immunosuppressive activity of the envelope protein (p15E) of feline leukemia virus (FeLV) and evaluate the effect of its abolition on the efficacy of a vaccine against FeLV. Here we demonstrate that the FeLV envelope protein is immunosuppressive in vivo and that this immunosuppressive activity can be "switched off" by targeted mutation of a specific amino acid. As a result of the introduction of the mutated envelope sequence into a previously well characterized canarypox virus-vectored vaccine (ALVAC-FeLV), the frequency of vaccine-induced FeLV-specific gamma interferon (IFN-γ)-producing cells was increased, whereas conversely, the frequency of vaccine-induced FeLV-specific interleukin-10 (IL-10)-producing cells was reduced. This shift in the IFN-γ/IL-10 response was associated with a higher efficacy of ALVAC-FeLV against FeLV infection. This study demonstrates that FeLV p15E is immunosuppressive in vivo, that the immunosuppressive domain of p15E can modulate the FeLV-specific immune response, and that the efficacy of FeLV vaccines can be enhanced by inhibiting the immunosuppressive activity of the IS domain through an appropriate mutation.

  10. Format for description of building envelope components for use in an optimization process

    DEFF Research Database (Denmark)

    Rudbeck, Claus Christian; Svendsen, Sv Aa Højgaard

    1999-01-01

    are decided by the architect or kept within limits due to public regulations, but even when these factors have been decided, some are left to be decided. Aspects like durability and the thermal performance are seldom specified by the architect, but might be addressed in national building codes. The national...... building codes specify minimum requirements for the aspects in question, but no trade-offs between the different aspects are allowed, being un-flexible. To allow for the use of optimization procedures in the design process a larger degree of flexibility is needed but first of all there is a need......When designing a building the number of possible combinations of aspects related to the performance of the building envelope are almost unlimited. Due to the physical laws governing e.g. the static performance of the building, some aspects should be kept within a certain interval. Other aspects...

  11. A Network-Based Data Envelope Analysis Model in a Dynamic Balanced Score Card

    Directory of Open Access Journals (Sweden)

    Mojtaba Akbarian

    2015-01-01

    Full Text Available Performance assessment during the time and along with strategies is the most important requirements of top managers. To assess the performance, a balanced score card (BSC along with strategic goals and a data envelopment analysis (DEA are used as powerful qualitative and quantitative tools, respectively. By integrating these two models, their strengths are used and their weaknesses are removed. In this paper, an integrated framework of the BSC and DEA models is proposed for measuring the efficiency during the time and along with strategies based on the time delay of the lag key performance indicators (KPIs of the BSC model. The causal relationships during the time among perspectives of the BSC model are drawn as dynamic BSC at first. Then, after identifying the network-DEA structure, a new objective function for measuring the efficiency of nine subsidiary refineries of the National Iranian Oil Refining and Distribution Company (NIORDC during the time and along with strategies is developed.

  12. L{sub g} coda moment rate spectra and discrimination using L{sub g} coda envelopes

    Energy Technology Data Exchange (ETDEWEB)

    Mayeda, K.M.; Walter, W.R. [Lawrence Livermore National Laboratory, CA (United States)

    1994-12-31

    Low magnitude seismic monitoring will depend largely on high frequency near-regional discriminants such as ratios of P to S energy and spectral amplitude ratios within P or S phases. Due to high frequency attenuation and sparse distribution of recording stations, small magnitude events will have to be identified with only a few stations, in some instances perhaps only one. Recently, stable single station magnitudes for explosions at NTS and moment rate spectra for earthquakes throughout the western U.S. have been estimated using L{sub g} coda envelopes. The averaging nature of coda waves virtually eliminates the amplitude variability due to source radiation anisotropy and lateral variations in path geology between the source and receiver. In this study, we find that L{sub g} coda spectral ratios are 3 to 4 times less variable than direct phase spectral ratio measurements. Events fired in low strength-high gas porosity material have higher spectral ratios than events in high strength-low gas porosity material, and thus discriminate well from earthquakes which have the lowest spectral ratios. In contrast, P{sub g}/L{sub g} phase ratios for events in low strength-high gas porosity material lie closest to the earthquake population. A combination of both discriminants performs better than either one does alone. Moment rate spectra for explosions show strong depth-dependent spectral peaking that is not observed in normal depth western U.S. earthquakes and is consistent with strong R{sub g} to S scattering near the explosion source. This explosion spectral peaking will be explored in future work as part of a possible broadband discriminant.

  13. Analysis of the documents about the core envelopment of nuclear reactor at the Laguna Verde U-1 power plant; Analisis de documentos de los materiales de la envolvente del nucleo del reactor nuclear de la CLV U-1

    Energy Technology Data Exchange (ETDEWEB)

    Zamora R, L.; Medina F, A. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1999-07-01

    The degradation of internal components at BWR type reactors is an important subject to consider in the performance availability of the power plant. The Wuergassen nuclear reactor license was confiscated due to the presence of cracking in the core envelopment. In consequence it is necessary carrying out a detailed study with the purpose to avoid these problems in the future. This report presents a review and analysis of documents and technical information referring to the core envelopment of a BWR/5/6 and the Laguna Verde Unit 1 nuclear reactor in Mexico. In this document are presented design data, documents about fabrication processes, and manufacturing of core envelopment. (Author)

  14. Comparison of recessed gate-head structures on normally-off AlGaN/GaN high-electron-mobility transistor performance.

    Science.gov (United States)

    Khan, Mansoor Ali; Heo, Jun-Woo; Kim, Hyun-Seok; Park, Hyun-Chang

    2014-11-01

    In this work, different gate-head structures have been compared in the context of AlGaN/GaN-based high-electron-mobility transistors (HEMTs). Field-plate (FP) technology self-aligned to the gate electrode leads to various gate-head structures, most likely gamma (γF)-gate, camel (see symbol)-gate, and mushroom-shaped (T)-gate. In-depth comparison of recessed gate-head structures demonstrated that key performance metrics such as transconductance, output current, and breakdown voltage are better with the T-gate head structure. The recessed T-gate with its one arm toward the source side not only reduces the source-access resistance (R(g) +R(gs)), but also minimizes the source-side dispersion and current leakage, resulting in high transconductance (G(m)) and output current (I(DS)). At the same time, the other arm toward the drain-side reduces the drain-side dispersion and tends to distribute electric field peaks uniformly, resulting in high breakdown voltage (V(BR)). DC and RF analysis showed that the recessed T-gate FP-HEMT is a suitable candidate not only for high-frequency operation, but also for high-power applications.

  15. Determinan Tingkat Efisiensi Perbankan Syariah Di Indonesia: Two Stages Data Envelopment Analysis

    Directory of Open Access Journals (Sweden)

    Zulfikar Bagus Pambuko

    2016-12-01

    Full Text Available Efficiency is an important indicator to observe the banks’ ability in resisting and facing the tight rivalry at banking industry. The study aims to evaluate the efficiency and to analyze the determinants of efficiency of Islamic bank in Indonesia on 2010 – 2013 with Two-Stage Data Envelopment Analysis approach. The objects of the study are 11 Islamic banks (BUS. The first phase of testing uses the Data Envelopment Analysis (DEA method showed that the efficiency of Islamic bank is inefficient on managing the resources and small Islamic banks are more efficient than the larger. The second phase of testing uses Tobit model showed that Capital Adequacy Ratio (CAR, Return on Asset (ROA, Non Performing Financing (NPF, Financing to Deposit Ratio (FDR, and Net Interest Margin (NIM have positive significant effect on the efficiency of Islamic banks, while Good Corporate Governance (GCG has a negative significant effect. Moreover, the macroeconomic variables, such as GDP growth and inflation have no significant effect on efficiency of Islamic banks. It suggests that to realize the optimum level of Islamic banks’ efficiency is only related with bank-specific, while the volatility of macroeconomics condition contributes nothing

  16. Determining the sensitivity of Data Envelopment Analysis method used in airport benchmarking

    Directory of Open Access Journals (Sweden)

    Mircea BOSCOIANU

    2013-03-01

    Full Text Available In the last decade there were some important changes in the airport industry, caused by the liberalization of the air transportation market. Until recently airports were considered infrastructure elements, and they were evaluated only by traffic values or their maximum capacity. Gradual orientation towards commercial led to the need of finding another ways of evaluation, more efficiency oriented. The existing methods for assessing efficiency used for other production units were not suitable to be used in case of airports due to specific features and high complexity of airport operations. In the last years there were some papers that proposed the Data Envelopment Analysis as a method for assessing the operational efficiency in order to conduct the benchmarking. This method offers the possibility of dealing with a large number of variables of different types, which represents the main advantage of this method and also recommends it as a good benchmarking tool for the airports management. This paper goal is to determine the sensitivity of this method in relation with its inputs and outputs. A Data Envelopment Analysis is conducted for 128 airports worldwide, in both input- and output-oriented measures, and the results are analysed against some inputs and outputs variations. Possible weaknesses of using DEA for assessing airports performance are revealed and analysed against this method advantages.

  17. Application of data envelopment analysis in measuring the efficiency of mutual fund

    Science.gov (United States)

    Nik, Marzieh Geramian; Mihanzadeh, Hooman; Izadifar, Mozhgan; Nik, Babak Geramian

    2015-05-01

    The growth of mutual fund industry during the past decades emphasizes the importance of this investment vehicle particularly in prosperity of financial markets and in turn, financial growth of each country. Therefore, evaluating the relative efficiency of mutual funds as investment tool is of importance. In this study, a combined model of DEA (data envelopment analysis), and goal programming (GoDEA) approaches contributes widely to analyze the return efficiency of Mutual Funds in an attempt to separate efficient and inefficient Funds as well as identifying the inefficiency resources. Mixed asset local funds, which are managed jointly by CIMB and Public Mutual Berhad, have been selected for the purpose of this paper. As a result, Public Small Cap Fund (P Small Cap) is regarded as the most efficient mutual fund during the period of study. The integrated model aims to first guide investors to choose the best performing fund among other mutual funds, secondly provides the realistic and appropriate benchmark in compare to other classic method, and finally confirms the utility of data envelopment analysis (DEA) as decision-making tool.

  18. A Joint Method of Envelope Inversion Combined with Hybrid-domain Full Waveform Inversion

    Science.gov (United States)

    CUI, C.; Hou, W.

    2017-12-01

    Full waveform inversion (FWI) aims to construct high-precision subsurface models by fully using the information in seismic records, including amplitude, travel time, phase and so on. However, high non-linearity and the absence of low frequency information in seismic data lead to the well-known cycle skipping problem and make inversion easily fall into local minima. In addition, those 3D inversion methods that are based on acoustic approximation ignore the elastic effects in real seismic field, and make inversion harder. As a result, the accuracy of final inversion results highly relies on the quality of initial model. In order to improve stability and quality of inversion results, multi-scale inversion that reconstructs subsurface model from low to high frequency are applied. But, the absence of very low frequencies (time domain and inversion in the frequency domain. To accelerate the inversion, we adopt CPU/GPU heterogeneous computing techniques. There were two levels of parallelism. In the first level, the inversion tasks are decomposed and assigned to each computation node by shot number. In the second level, GPU multithreaded programming is used for the computation tasks in each node, including forward modeling, envelope extraction, DFT (discrete Fourier transform) calculation and gradients calculation. Numerical tests demonstrated that the combined envelope inversion + hybrid-domain FWI could obtain much faithful and accurate result than conventional hybrid-domain FWI. The CPU/GPU heterogeneous parallel computation could improve the performance speed.

  19. Normalized modes at selected points without normalization

    Science.gov (United States)

    Kausel, Eduardo

    2018-04-01

    As every textbook on linear algebra demonstrates, the eigenvectors for the general eigenvalue problem | K - λM | = 0 involving two real, symmetric, positive definite matrices K , M satisfy some well-defined orthogonality conditions. Equally well-known is the fact that those eigenvectors can be normalized so that their modal mass μ =ϕT Mϕ is unity: it suffices to divide each unscaled mode by the square root of the modal mass. Thus, the normalization is the result of an explicit calculation applied to the modes after they were obtained by some means. However, we show herein that the normalized modes are not merely convenient forms of scaling, but that they are actually intrinsic properties of the pair of matrices K , M, that is, the matrices already "know" about normalization even before the modes have been obtained. This means that we can obtain individual components of the normalized modes directly from the eigenvalue problem, and without needing to obtain either all of the modes or for that matter, any one complete mode. These results are achieved by means of the residue theorem of operational calculus, a finding that is rather remarkable inasmuch as the residues themselves do not make use of any orthogonality conditions or normalization in the first place. It appears that this obscure property connecting the general eigenvalue problem of modal analysis with the residue theorem of operational calculus may have been overlooked up until now, but which has in turn interesting theoretical implications.Á

  20. The viral envelope is not sufficient to transfer the unique broad cell tropism of Bungowannah virus to a related pestivirus.

    Science.gov (United States)

    Richter, Maria; Reimann, Ilona; Schirrmeier, Horst; Kirkland, Peter D; Beer, Martin

    2014-10-01

    Bungowannah virus is the most divergent pestivirus, and both origin and reservoir host have not been identified so far. We therefore performed in vitro tropism studies, which showed that Bungowannah virus differs remarkably from other pestiviruses. Interestingly, cell lines of vervet monkey, mouse, human and even of bat origin were susceptible. This broad in vitro tropism was not observed for a chimeric bovine viral diarrhoea virus (BVDV) expressing all structural proteins of Bungowannah virus. The viral envelope was not sufficient to completely transfer the cell tropism of Bungowannah virus to another pestivirus, and viral RNA replication was either markedly reduced or not detectable in a number of different cell lines for the tested BVDV strain and the chimera. We therefore suggest that the replication machinery together with the viral envelope is responsible for the unique broad cell tropism of Bungowannah virus. © 2014 The Authors.