New Nordic Exceptionalism

DEFF Research Database (Denmark)

Danbolt, Mathias

2016-01-01

At the 2009 Nordic Culture Forum summit in Berlin that centered on the profiling and branding of the Nordic region in a globalized world, one presenter stood out from the crowd. The lobbyist Annika Sigurdardottir delivered a speech that called for the establishment of “The United Nations of Norden...... that have been central to the debates on the branding of Nordicity over the last decades: on the one hand, the discourse of “Nordic exceptionalism,” that since the 1960s has been central to the promotion of a Nordic political, socio-economic, and internationalist “third way” model, and, on the other hand......, the discourse on the “New Nordic,” that emerged out of the New Nordic Food-movement in the early 2000s, and which has given art and culture a privileged role in the international re-fashioning of the Nordic brand. Through an analysis of Kim and Einhorn’s United Nations of Norden (UNN)-performance, the article...

Preclinical studies in support of defibrotide for the treatment of multiple myeloma and other neoplasias.

Science.gov (United States)

Mitsiades, Constantine S; Rouleau, Cecile; Echart, Cinara; Menon, Krishna; Teicher, Beverly; Distaso, Maria; Palumbo, Antonio; Boccadoro, Mario; Anderson, Kenneth C; Iacobelli, Massimo; Richardson, Paul G

2009-02-15

Defibrotide, an orally bioavailable polydisperse oligonucleotide, has promising activity in hepatic veno-occlusive disease, a stem cell transplantation-related toxicity characterized by microangiopathy. The antithrombotic properties of defibrotide and its minimal hemorrhagic risk could serve for treatment of cancer-associated thrombotic complications. Given its cytoprotective effect on endothelium, we investigated whether defibrotide protects tumor cells from cytotoxic antitumor agents. Further, given its antiadhesive properties, we evaluated whether defibrotide modulates the protection conferred to multiple myeloma cells by bone marrow stromal cells. Defibrotide lacks significant single-agent in vitro cytotoxicity on multiple myeloma or solid tumor cells and does not attenuate their in vitro response to dexamethasone, bortezomib, immunomodulatory thalidomide derivatives, and conventional chemotherapeutics, including melphalan and cyclophosphamide. Importantly, defibrotide enhances in vivo chemosensitivity of multiple myeloma and mammary carcinoma xenografts in animal models. In cocultures of multiple myeloma cells with bone marrow stromal cells in vitro, defibrotide enhances the multiple myeloma cell sensitivity to melphalan and dexamethasone, and decreases multiple myeloma-bone marrow stromal cell adhesion and its sequelae, including nuclear factor-kappaB activation in multiple myeloma and bone marrow stromal cells, and associated cytokine production. Moreover, defibrotide inhibits expression and/or function of key mediators of multiple myeloma interaction with bone marrow stromal cell and endothelium, including heparanase, angiogenic cytokines, and adhesion molecules. Defibrotide's in vivo chemosensitizing properties and lack of direct in vitro activity against tumor cells suggest that it favorably modulates antitumor interactions between bone marrow stromal cells and endothelia in the tumor microenvironment. These data support clinical studies of defibrotide in

In Search of Nordicity

DEFF Research Database (Denmark)

Ooi, Can-Seng; Strandgaard, Jesper

2017-01-01

This article looks at the branding of Copenhagen as a food destination through the advent of the New Nordic Cuisine movement and how this may change the way we think about destination branding. The destination management organization of Copenhagen opportunistically embraced the New Nordic Cuisine...... an inductive, in-depth, longitudinal study of the New Nordic Cuisine and its movement's development in relation to branding Copenhagen as a tourism destination....

Donor versus no-donor comparison of newly diagnosed myeloma patients included in the HOVON-50 multiple myeloma study

NARCIS (Netherlands)

Lokhorst, Henk M.; van der Holt, Bronno; Cornelissen, Jan J.; Kersten, Marie-José; van Oers, Marinus; Raymakers, Reinier; Minnema, Monique C.; Zweegman, Sonja; Janssen, Jeroen J.; Zijlmans, Mark; Bos, Gerard; Schaap, Nicolaas; Wittebol, Shulamiet; de Weerdt, Okke; Ammerlaan, Rianne; Sonneveld, Pieter

2012-01-01

To prospectively evaluate allogeneic stem cell transplantation (allo-SCT) for myeloma as part of first-line therapy, a donor versus no-donor analysis was performed of patients treated in the HOVON-50 study, a study that was originally designed to examine thalidomide combined with intensive therapy.

Cyclic AMP induces apoptosis in multiple myeloma cells and inhibits tumor development in a mouse myeloma model

International Nuclear Information System (INIS)

Follin-Arbelet, Virginie; Hofgaard, Peter O; Hauglin, Harald; Naderi, Soheil; Sundan, Anders; Blomhoff, Rune; Bogen, Bjarne; Blomhoff, Heidi K

2011-01-01

Multiple myeloma is an incurable disease requiring the development of effective therapies which can be used clinically. We have elucidated the potential for manipulating the cAMP signaling pathway as a target for inhibiting the growth of multiple myeloma cells. As a model system, we primarily used the murine multiple myeloma cell line MOPC315 which can be grown both in vivo and in vitro. Human multiple myeloma cell lines U266, INA-6 and the B-cell precursor acute lymphoblastic leukemia cell line Reh were used only for in vitro studies. Cell death was assessed by flow cytometry and western blot analysis after treatment with cAMP elevating agents (forskolin, prostaglandin E2 and rolipram) and cAMP analogs. We followed tumor growth in vivo after forskolin treatment by imaging DsRed-labelled MOPC315 cells transplanted subcutaneously in BALB/c nude mice. In contrast to the effect on Reh cells, 50 μM forskolin more than tripled the death of MOPC315 cells after 24 h in vitro. Forskolin induced cell death to a similar extent in the human myeloma cell lines U266 and INA-6. cAMP-mediated cell death had all the typical hallmarks of apoptosis, including changes in the mitochondrial membrane potential and cleavage of caspase 3, caspase 9 and PARP. Forskolin also inhibited the growth of multiple myeloma cells in a mouse model in vivo. Elevation of intracellular levels of cAMP kills multiple myeloma cells in vitro and inhibits development of multiple myeloma in vivo. This strongly suggests that compounds activating the cAMP signaling pathway may be useful in the field of multiple myeloma

Young Adult and Usual Adult Body Mass Index and Multiple Myeloma Risk: A Pooled Analysis in the International Multiple Myeloma Consortium (IMMC).

Science.gov (United States)

Birmann, Brenda M; Andreotti, Gabriella; De Roos, Anneclaire J; Camp, Nicola J; Chiu, Brian C H; Spinelli, John J; Becker, Nikolaus; Benhaim-Luzon, Véronique; Bhatti, Parveen; Boffetta, Paolo; Brennan, Paul; Brown, Elizabeth E; Cocco, Pierluigi; Costas, Laura; Cozen, Wendy; de Sanjosé, Silvia; Foretová, Lenka; Giles, Graham G; Maynadié, Marc; Moysich, Kirsten; Nieters, Alexandra; Staines, Anthony; Tricot, Guido; Weisenburger, Dennis; Zhang, Yawei; Baris, Dalsu; Purdue, Mark P

2017-06-01

Background: Multiple myeloma risk increases with higher adult body mass index (BMI). Emerging evidence also supports an association of young adult BMI with multiple myeloma. We undertook a pooled analysis of eight case-control studies to further evaluate anthropometric multiple myeloma risk factors, including young adult BMI. Methods: We conducted multivariable logistic regression analysis of usual adult anthropometric measures of 2,318 multiple myeloma cases and 9,609 controls, and of young adult BMI (age 25 or 30 years) for 1,164 cases and 3,629 controls. Results: In the pooled sample, multiple myeloma risk was positively associated with usual adult BMI; risk increased 9% per 5-kg/m 2 increase in BMI [OR, 1.09; 95% confidence interval (CI), 1.04-1.14; P = 0.007]. We observed significant heterogeneity by study design ( P = 0.04), noting the BMI-multiple myeloma association only for population-based studies ( P trend = 0.0003). Young adult BMI was also positively associated with multiple myeloma (per 5-kg/m 2 ; OR, 1.2; 95% CI, 1.1-1.3; P = 0.0002). Furthermore, we observed strong evidence of interaction between younger and usual adult BMI ( P interaction adult BMI may increase multiple myeloma risk and suggest that healthy BMI maintenance throughout life may confer an added benefit of multiple myeloma prevention. Cancer Epidemiol Biomarkers Prev; 26(6); 876-85. ©2017 AACR . ©2017 American Association for Cancer Research.

Adherence to the Nordic Nutrition Recommendations in a Nordic population with metabolic syndrome: high salt consumption and low dietary fibre intake (The SYSDIET study).

Science.gov (United States)

Jonsdottir, Svandis Erna; Brader, Lea; Gunnarsdottir, Ingibjorg; Kally Magnusdottir, Ola; Schwab, Ursula; Kolehmainen, Marjukka; Risérus, Ulf; Herzig, Karl-Heinz; Cloetens, Lieselotte; Helgegren, Hannah; Johansson-Persson, Anna; Hukkanen, Janne; Poutanen, Kaisa; Uusitupa, Matti; Hermansen, Kjeld; Thorsdottir, Inga

2013-12-16

The Nordic countries collaborate in setting recommendations for intake of nutrients by publishing the Nordic Nutrition Recommendations (NNR). Studies exploring how well the Nordic population adheres to the NNR are limited and none are available for the metabolic syndrome (MetS) subgroup. Individuals with MetS are a large part of the adult Nordic population and their diet's nutritional quality is of great importance as it can affect the progression of MetS. To evaluate nutritional intake in a cohort of Nordic adults with MetS or MetS risk factors and their adherence to the NNR. A multi-centre study was carried out in six centres in four Nordic countries (SYSDIET CoE). Participants (n=175) were 30-65 years of age, with BMI 27-38 kg/m(2) and had at least two criteria for MetS. The NNR was used to evaluate the baseline nutrient intake calculated from the participants' 4-day food diaries using national nutrient databases. Less than 20% of participants consumed ≤10 E% from saturated fat as recommended in the NNR. Recommended intake (RI) of polyunsaturated fat was met by approximately one-third of participants. Only 20% of men and 26% of women met the RI of dietary fibre. Intake below the defined lower intake level of 2.5 µg/day for vitamin D was observed in nearly 20% of participants. The daily median intake of salt was 8.8 g for men and 6.7 g for women. Dietary quality of this Nordic population with Mets or MetS risk factors is unsatisfactory and characterised by high intakes of SFA and sodium and low intakes of PUFA and dietary fibre. Vitamin D intake was below RI level in a large part of the population. Authorities in the Nordic countries are encouraged to develop intervention programmes for high-risk groups.

Perspectives on Nordic Working Life Research

Directory of Open Access Journals (Sweden)

Jan Ch. Karlsson

2013-09-01

Full Text Available Welcome to this Thematic Issue on Perspectives on Nordic Working Life Research! It is perhaps not that surprising that a journal called Nordic Journal of Working Life Studies contains many discussions about “Nordic Models”: What is the Nordic Welfare State Model? What has happened to it lately? Is there still one? Has there ever been one? What about the Nordic Industrial Relations Model—is it on its way to be abandoned? And the Nordic Labor Market Model? Or the Nordic Work Environment Model? In contrast, in the Thematic Issue part of this issue of NJWLS Nordic working life research itself is discussed. Editing the issue has led me to some (selfcritical reflections on Nordic working life research—or perhaps rather reflections on the self-image of Nordic working life researchers. We often say that two of the cornerstones of Nordic working life research are the assumption that there is a positive correlation between employee autonomy at work and higher productivity, and that our research tradition is different from those found in other geographical areas (and, implicitly, probably better. Being part of the Nordic tradition, I too have claimed both, but I now think both needs to be qualified and critically discussed. Or rather, the first needs to be qualified and the consequences of the other critically evaluated (...

Natural killer cell lines preferentially kill clonogenic multiple myeloma cells and decrease myeloma engraftment in a bioluminescent xenograft mouse model.

Science.gov (United States)

Swift, Brenna E; Williams, Brent A; Kosaka, Yoko; Wang, Xing-Hua; Medin, Jeffrey A; Viswanathan, Sowmya; Martinez-Lopez, Joaquin; Keating, Armand

2012-07-01

Novel therapies capable of targeting drug resistant clonogenic MM cells are required for more effective treatment of multiple myeloma. This study investigates the cytotoxicity of natural killer cell lines against bulk and clonogenic multiple myeloma and evaluates the tumor burden after NK cell therapy in a bioluminescent xenograft mouse model. The cytotoxicity of natural killer cell lines was evaluated against bulk multiple myeloma cell lines using chromium release and flow cytometry cytotoxicity assays. Selected activating receptors on natural killer cells were blocked to determine their role in multiple myeloma recognition. Growth inhibition of clonogenic multiple myeloma cells was assessed in a methylcellulose clonogenic assay in combination with secondary replating to evaluate the self-renewal of residual progenitors after natural killer cell treatment. A bioluminescent mouse model was developed using the human U266 cell line transduced to express green fluorescent protein and luciferase (U266eGFPluc) to monitor disease progression in vivo and assess bone marrow engraftment after intravenous NK-92 cell therapy. Three multiple myeloma cell lines were sensitive to NK-92 and KHYG-1 cytotoxicity mediated by NKp30, NKp46, NKG2D and DNAM-1 activating receptors. NK-92 and KHYG-1 demonstrated 2- to 3-fold greater inhibition of clonogenic multiple myeloma growth, compared with killing of the bulk tumor population. In addition, the residual colonies after treatment formed significantly fewer colonies compared to the control in a secondary replating for a cumulative clonogenic inhibition of 89-99% at the 20:1 effector to target ratio. Multiple myeloma tumor burden was reduced by NK-92 in a xenograft mouse model as measured by bioluminescence imaging and reduction in bone marrow engraftment of U266eGFPluc cells by flow cytometry. This study demonstrates that NK-92 and KHYG-1 are capable of killing clonogenic and bulk multiple myeloma cells. In addition, multiple myeloma

The impact of comorbidity on mortality in multiple myeloma

DEFF Research Database (Denmark)

Gregersen, Henrik; Vangsted, Annette Juul; Abildgaard, Niels

2017-01-01

To describe the prevalence of comorbidity and its impact on survival in newly diagnosed multiple myeloma patients compared with population controls. Cases of newly diagnosed symptomatic multiple myeloma during the 2005-2012 period were identified in the Danish National Multiple Myeloma Registry....... For each myeloma patient, 10 members of the general population matched by age and sex were chosen from the national Civil Registration System. Data on comorbidity in the myeloma patients and the general population comparison cohort were collected by linkage to the Danish National Patient Registry (DNPR......). Cox proportional hazards regression models were used to evaluate the prognostic significance of comorbidity. The study included 2190 cases of multiple myeloma and 21,900 population controls. The comorbidity was increased in multiple myeloma patients compared with population controls, odds ratio (OR) 1...

Nordic walking and chronic low back pain

DEFF Research Database (Denmark)

Morsø, Lars; Hartvigsen, Jan; Puggaard, Lis

2006-01-01

activity provide similar benefits. Nordic Walking is a popular and fast growing type of exercise in Northern Europe. Initial studies have demonstrated that persons performing Nordic Walking are able to exercise longer and harder compared to normal walking thereby increasing their cardiovascular metabolism....... Until now no studies have been performed to investigate whether Nordic Walking has beneficial effects in relation to low back pain. The primary aim of this study is to investigate whether supervised Nordic Walking can reduce pain and improve function in a population of chronic low back pain patients...... when compared to unsupervised Nordic Walking and advice to stay active. In addition we investigate whether there is an increase in the cardiovascular metabolism in persons performing supervised Nordic Walking compared to persons who are advised to stay active. Finally, we investigate whether...

Can dentists detect multiple myeloma through oral manifestations?

Directory of Open Access Journals (Sweden)

Thaís Miranda Xavier de Almeida

2018-01-01

Full Text Available Objective: To review published data on oral manifestations of multiple myeloma. Methods: An electronic database search was performed of articles published from 1971 to November 2016 in order to identify studies that reported oral manifestations of patients with multiple myeloma. Case reports and case series with oral manifestations of multiple myeloma in English were included in the study. An additional search was performed of the references of the selected articles. Results: Thirty-seven articles that reported 81 patients with oral manifestations of multiple myeloma were selected: 30 case reports (82% and seven case series (18%. The most common clinical features in the dental cavity were swelling (65.4%, bone pain (33.3%, paresthesia (27.1% and amyloidosis lesions (11.1%. Osteolytic lesions detected on imaging exams were reported in the majority of the patients (90.1% as plasmacytomas or ‘punched-out’ lesions. Conclusions: Swelling and osteolytic lesions represent the most common clinical and radiographic signs of the jaws relating to multiple myeloma, respectively. Keywords: Multiple Myeloma, Oral Manifestations, Mouth, Jaws

Adherence to the Nordic Nutrition Recommendations in a Nordic population with metabolic syndrome: high salt consumption and low dietary fibre intake (The SYSDIET study

Directory of Open Access Journals (Sweden)

Svandis Erna Jonsdottir

2013-12-01

Full Text Available Background: The Nordic countries collaborate in setting recommendations for intake of nutrients by publishing the Nordic Nutrition Recommendations (NNR. Studies exploring how well the Nordic population adheres to the NNR are limited and none are available for the metabolic syndrome (MetS subgroup. Individuals with MetS are a large part of the adult Nordic population and their diet's nutritional quality is of great importance as it can affect the progression of MetS. Objective: To evaluate nutritional intake in a cohort of Nordic adults with MetS or MetS risk factors and their adherence to the NNR. Design: A multi-centre study was carried out in six centres in four Nordic countries (SYSDIET CoE. Participants (n=175 were 30–65 years of age, with BMI 27–38 kg/m2 and had at least two criteria for MetS. The NNR was used to evaluate the baseline nutrient intake calculated from the participants’ 4-day food diaries using national nutrient databases. Results: Less than 20% of participants consumed ≤10 E% from saturated fat as recommended in the NNR. Recommended intake (RI of polyunsaturated fat was met by approximately one-third of participants. Only 20% of men and 26% of women met the RI of dietary fibre. Intake below the defined lower intake level of 2.5 µg/day for vitamin D was observed in nearly 20% of participants. The daily median intake of salt was 8.8 g for men and 6.7 g for women. Conclusion: Dietary quality of this Nordic population with Mets or MetS risk factors is unsatisfactory and characterised by high intakes of SFA and sodium and low intakes of PUFA and dietary fibre. Vitamin D intake was below RI level in a large part of the population. Authorities in the Nordic countries are encouraged to develop intervention programmes for high-risk groups.

Nordic Branding Podcast 4

DEFF Research Database (Denmark)

2017-01-01

Reflections on Nordic branding with professor Dannie Kjeldgaard. Why Nordic regionality and why now? What is the dynamics of local/global/glocal/regional?......Reflections on Nordic branding with professor Dannie Kjeldgaard. Why Nordic regionality and why now? What is the dynamics of local/global/glocal/regional?...

The Nordic Housing Enabler

DEFF Research Database (Denmark)

Helle, T.; Nygren, C.; Slaug, B.

2014-01-01

This study addresses development of a content-valid cross-Nordic version of the Housing Enabler and investigation of its inter-rater reliability when used in occupational therapy rating situations, involving occupational therapists, clients, and their home environments. The instrument was transla......This study addresses development of a content-valid cross-Nordic version of the Housing Enabler and investigation of its inter-rater reliability when used in occupational therapy rating situations, involving occupational therapists, clients, and their home environments. The instrument...... was translated from the original Swedish version of the Housing Enabler, and adapted according to accessibility norms and guidelines for housing design in Sweden, Denmark, Finland, and Iceland. This iterative process involved occupational therapists, architects, building engineers, and professional translators......, resulting in the Nordic Housing Enabler. For reliability testing, the sampling strategy and data collection procedures used were the same in all countries. Twenty voluntary occupational therapists, pair-wise but independently of each other, collected data from 106 cases by means of the Nordic Housing...

Sedation practice in Nordic and non-Nordic ICUs

DEFF Research Database (Denmark)

Egerod, Ingrid; Albarran, John W; Ring, Mette

2013-01-01

A trend towards lighter sedation has been evident in many intensive care units (ICUs). The aims of the survey were to describe sedation practice in European ICUs and to compare sedation practice in Nordic and non-Nordic countries....

Technetium-99m Sestamibi in Multiple Myeloma

International Nuclear Information System (INIS)

Saber, R.A.

2002-01-01

Technetium-99m 2-methoxy - isobutyl - isonitrile (99mTc-MIBI) has been reported to be useful in evaluating patients with multiple myeloma. The aim of this study is to evaluate the role of technetium-99m sestamibi (99mTc-MIBI) scintigraphy in the diagnosis. staging and follow-up of patients with multiple myeloma. Methods and Materials: twenty-five consecutive patients with multiple myeloma were studied using 99mTc- MIBI. Of the 25 patients included in this study, 6 were in stage I, II in stage II and 8 in stage III. Anterior and posterior whole-body imaging were obtained 20 min after I.V. injection of 740 MBq of 99mTc-MIBI. Four different MIBI patterns could be described in our patients: physiological (P), diffuse (D), focal (F) and combined diffuse and focal (D+F). All patients in stages II and III as well as 3 patients in stage I were treated with chemotherapy (cyclophosphamide and prednisone) then 99mTc-MlBI scans were repeated after 6 courses. Results: in comparison to conventional X-ray skeletal survey, 99mTc-MIBI scans showed a higher number of myeloma bone disease at diagnosis. All patients with stage II and III multiple myeloma were positive with 99mTc-MlBl scans at diagnosis. The pattern of positive MIBI accumulation was diffuse in 13 (52%) patients, focal in 4 (16%) and combined focal and diffuse in 6 (24%) patients. The intensity of 99mTc-MIBI correlated with disease activity as determined by lactate dehydrogenase (LDH), number of plasma cells in bone marrow and serum electrophoresis. There was a direct correlation between 99mTc-MIBI scan result and clinical outcome of patients following 6 courses of chemotherapy. Sensitivity and specificity of 99mTc-MIBI scintigraphy in detecting myeloma bone lesions were 92% and 90% respectively. Conclusion: 99mTc-MIBI scintigraphy is a reliable method to evaluate bone marrow activity in patients with multiple myeloma and follow-up of myeloma bone lesions

Hypercalcaemia : myeloma

International Nuclear Information System (INIS)

Naude, F; Venter, E.K.; Meyer, B.J.

2004-01-01

Full text: Introduction: A hypercalcaemic patient was referred to the Department of Nuclear Medicine to localise a parathyroid adenoma pre-operatively. Instead of an adenoma, multiple myeloma was diagnosed - comprimed histologically. Conclusion: Many conditions are associated with hypercalcaemia. Principal causes are primary hyperparathyroidism, advanced secondary hyperparathyroidism, milk alkali syndrome, vitamin D intoxication, Vit A intoxication, thiazide diuretic treatment, malignancy. Primary hyperparathyroidism (pHPT) is the most common cause in ambulatory adult patients, and malignancy the leading cause in hospitalised patients. Radioscintigraphic imaging of the parathyroids is one of the procedures used to localise the site of parathyroid adenomas. Currently 99mTc-sestamibi is the radioactive agent of choice. Hypercalcaemia is a relative frequent phenomenon in many malignant disorders, but seems to be insufficiently recognised. Various patterns of 99mTc-sestamibi uptake in the bone marrow of multiple myeloma patients have been reported: normal (negative), focal. diffuse and combined focal and diffuse. Diffuse and/or focal 99mTc-sestamibi uptake in the bone marrow is almost diagnostic of multiple myeloma. The distribution and intensity of 99mTc-sestamibi uptake are related to both the clinical status and stage of the disease, and can be used to estimate the success of therapy; a negative sestamibi study in patients receiving therapy indicates remission. (author)

The Nordic Nuclear Safety Research (NKS) programme. Nordic cooperation on nuclear safety

Energy Technology Data Exchange (ETDEWEB)

Andersson, Kasper G. [Technical Univ. of Denmark, Roskilde (Denmark). National Lab. for Sustainable Energy; Ekstroem, Karoliina [Fortum Power and Heat, Fortum (Finland); Gwynn, Justin P. [Norwegian Radiation Protection Authority, Tromsoe (Norway). Fram Centre; Magnusson, Sigurdur M. [Icelandic Radiation Safety Authority, Reykjavik (Iceland); Physant, Finn C. [NKS-Sekretariatet, Roskilde (Denmark)

2012-07-01

The roots of the current Nordic Nuclear Safety Research (NKS) programme can be traced back to the recommendation by the Nordic Council in the late 1950s for the establishment of joint Nordic committees on the issues of nuclear research and radiation protection. One of these joint Nordic committees, the 'Kontaktorgan', paved the way over its 33 years of existence for the future of Nordic cooperation in the field of nuclear safety, through the formation of Nordic groups on reactor safety, nuclear waste and environmental effects of nuclear power in the late 1960s and early 1970s. With an increased focus on developing nuclear power in the wake of the energy crisis on the 1970s, the NKS was established by the Nordic Council to further develop the previous strands of Nordic cooperation in nuclear safety. NKS started its first programme in 1977, funding a series of four year programmes over the next 24 years covering the areas of reactor safety, waste management, emergency preparedness and radioecology. Initially funded directly from the Nordic Council, ownership of NKS was transferred from the political level to the national competent authorities at the beginning of the 1990s. This organizational and funding model has continued to the present day with additional financial support from a number of co-sponsors in Finland, Norway and Sweden. (orig.)

Immunomodulation of multiple myeloma.

Science.gov (United States)

Tohnya, Tanyifor M; Figg, William D

2004-11-01

Multiple myeloma is a multi-process disease, and these different processes are responsible for the reduced sensitivity to chemotherapy and radiotherapy, hence the relapse and refractory nature of multiple myeloma. Emphasis is now placed on the hypothesis that myeloma cell growth, inhibition of apoptosis and drug resistance are dependent on immunomodulatory cytokines such as IL-6 and pro-angiogenic factors such as VEGF. In addition to its anti-angiogenic effects, the immunomodulatory properties of thalidomide make it a possible therapy for patients with advanced multiple myeloma. This has lead to the clinical development of a number of immunomodulatory thalidomide analogues (IMiDs) which are more potent and have less side effects than the parent drug, thalidomide. In the August 15(th) issue of Journal of Clinical Oncology, Schey SA et al. suggested that an IMiD (CC-4047) maybe efficacious due to T-cell co-stimulation, and safe in patients with relapsed or refractory multiple myeloma. This article demonstrates a supporting role for IMiDs as immunomodulatory adjuvant therapy.

Locating Nordic Noir

DEFF Research Database (Denmark)

Hansen, Kim Toft; Waade, Anne Marit

such as Beck, The Killing, Trapped and The Bridge as well as a range of other important Nordic Noir cases. The book positions the development of Nordic Noir on the global market for popular television drama and places the international attention towards Nordic crime dramas within regional development of drama...

Skeletal surveys in multiple myeloma

International Nuclear Information System (INIS)

Sebes, J.I.; Niell, H.B.; Palmieri, G.M.A.; Reidy, T.J.

1986-01-01

Thirty-three patients with multiple myeloma were studied with serial skeletal surveys, serum immunoglobulin levels, and postabsorptive urinary hydroxyproline (Spot-HYPRO) determinations. Twenty receiving chemotherapy were also followed with skeletal surveys in order to evaluate bone response to treatment. A close association was found between skeletal findings and changes in immunoglubulin levels with positive correlation in 71% of the patients. A similar association was found between skeletal disease and Spot-HYPRO level changes in 65%. Five of 12 patients (42%) with partial or complete clinical response to chemotherapy, demonstrated improvement in the appearance of skeletal lesions. Positive correlation between the roentgenographic changes and clinical markers of myeloma as well as therapeutic response, indicates that skeletal surveys are useful and effective in monitoring patients with multiple myeloma. (orig.)

Nordic reference study on uncertainty and sensitivity analysis

International Nuclear Information System (INIS)

Hirschberg, S.; Jacobsson, P.; Pulkkinen, U.; Porn, K.

1989-01-01

This paper provides a review of the first phase of Nordic reference study on uncertainty and sensitivity analysis. The main objective of this study is to use experiences form previous Nordic Benchmark Exercises and reference studies concerning critical modeling issues such as common cause failures and human interactions, and to demonstrate the impact of associated uncertainties on the uncertainty of the investigated accident sequence. This has been done independently by three working groups which used different approaches to modeling and to uncertainty analysis. The estimated uncertainty interval for the analyzed accident sequence is large. Also the discrepancies between the groups are substantial but can be explained. Sensitivity analyses which have been carried out concern e.g. use of different CCF-quantification models, alternative handling of CCF-data, time windows for operator actions and time dependences in phase mission operation, impact of state-of-knowledge dependences and ranking of dominating uncertainty contributors. Specific findings with respect to these issues are summarized in the paper

Melancholy in Nordic Noir

DEFF Research Database (Denmark)

Waade, Anne Marit

2017-01-01

Nordic noir on screen is characterised by a certain melancholy displayed in the plot, the imagery and the characters. These elements also characterise Scandinavian crime fiction, for example, the troubled protagonists and the cold climate. Nordic noir has attracted considerable interest among...... audiences and academics. However, none of the academic contributions reflect the connection to the historical Nordic melancholy. In this article, I relate Nordic noir to Nordic melancholy in art, philosophy and culture in which melancholy as a romantic ideal was embedded in a particular landscape...

Nordic Energy Technologies : Enabling a sustainable Nordic energy future

Energy Technology Data Exchange (ETDEWEB)

Vik, Amund; Smith, Benjamin

2009-10-15

A high current Nordic competence in energy technology and an increased need for funding and international cooperation in the field are the main messages of the report. This report summarizes results from 7 different research projects relating to policies for energy technology, funded by Nordic Energy Research for the period 2007-2008, and provides an analysis of the Nordic innovation systems in the energy sector. The Nordic countries possess a high level of competence in the field of renewable energy technologies. Of the total installed capacity comprises a large share of renewable energy, and Nordic technology companies play an important role in the international market. Especially distinguished wind energy, both in view of the installed power and a global technology sales. Public funding for energy research has experienced a significant decline since the oil crisis of the 1970s, although the figures in recent years has increased a bit. According to the IEA, it will require a significant increase in funding to reduce greenhouse gas emissions and limit further climate change. The third point highlighted in the report is the importance of international cooperation in energy research. Nordic and international cooperation is necessary in order to reduce duplication and create the synergy needed if we are to achieve our ambitious policy objectives in the climate and energy issue. (AG)

Policy responses to hepatitis C in the Nordic countries: Gaps and discrepant reporting in the Hep-Nordic study.

Directory of Open Access Journals (Sweden)

Kelly Safreed-Harmon

Full Text Available In the Nordic countries (Denmark, Finland, Iceland, Norway, Sweden, the prevalence of chronic hepatitis C virus (HCV infection is relatively low in the general population, but is much higher among people who inject drugs (PWID. We conducted an exploratory study to investigate the extent to which these countries have policies supporting key elements of the public health response that is necessary to achieve the global goal of eliminating HCV as a public health threat.Fourteen stakeholders representing government agencies, medical societies, and civil society organisations (CSOs in the Nordic countries completed a cross-sectional online survey that included 21 policy questions related to national coordination, prevention, testing, linkage to care, and treatment. We summarised the findings in a descriptive analysis, and noted discrepant responses from stakeholders within the same country.Stakeholders reported that three of the five study countries have national viral hepatitis strategies, while only Iceland has a national HCV elimination goal. The availability of harm reduction services varies, with opioid substitution therapy provided for the general population throughout all countries, but not needle and syringe programmes. No country has access to anonymous HCV testing in all parts of the country. National HCV treatment guidelines are available in all countries except Finland, and all countries provide publicly funded direct-acting antiviral treatment. Disagreement regarding policies was observed across countries, and CSOs were the stakeholder group that most frequently answered survey questions incorrectly.The Nordic region as a whole has not consistently expressed its commitment to tackling HCV, despite the existence of large HCV epidemics among PWID in these countries. Stakeholder alignment and an established elimination goal with an accompanying strategy and implementation plan should be recognised as the basis for coordinated national

Policy responses to hepatitis C in the Nordic countries: Gaps and discrepant reporting in the Hep-Nordic study.

Science.gov (United States)

Safreed-Harmon, Kelly; Hetherington, Kristina L; Aleman, Soo; Alho, Hannu; Dalgard, Olav; Frisch, Tove; Gottfredsson, Magnus; Weis, Nina; Lazarus, Jeffrey V

2018-01-01

In the Nordic countries (Denmark, Finland, Iceland, Norway, Sweden), the prevalence of chronic hepatitis C virus (HCV) infection is relatively low in the general population, but is much higher among people who inject drugs (PWID). We conducted an exploratory study to investigate the extent to which these countries have policies supporting key elements of the public health response that is necessary to achieve the global goal of eliminating HCV as a public health threat. Fourteen stakeholders representing government agencies, medical societies, and civil society organisations (CSOs) in the Nordic countries completed a cross-sectional online survey that included 21 policy questions related to national coordination, prevention, testing, linkage to care, and treatment. We summarised the findings in a descriptive analysis, and noted discrepant responses from stakeholders within the same country. Stakeholders reported that three of the five study countries have national viral hepatitis strategies, while only Iceland has a national HCV elimination goal. The availability of harm reduction services varies, with opioid substitution therapy provided for the general population throughout all countries, but not needle and syringe programmes. No country has access to anonymous HCV testing in all parts of the country. National HCV treatment guidelines are available in all countries except Finland, and all countries provide publicly funded direct-acting antiviral treatment. Disagreement regarding policies was observed across countries, and CSOs were the stakeholder group that most frequently answered survey questions incorrectly. The Nordic region as a whole has not consistently expressed its commitment to tackling HCV, despite the existence of large HCV epidemics among PWID in these countries. Stakeholder alignment and an established elimination goal with an accompanying strategy and implementation plan should be recognised as the basis for coordinated national public health

[Diagnostic and evolutionary profile of multiple myeloma in Senegal: monocentric study conducted from 2005 to 2016].

Science.gov (United States)

Fall, Seynabou; Dieng, Fatma; Diouf, Coumba; Djiba, Boundia; Ndao, Awa Cheikh; Ndiaye, Fatou Samba Diago

2017-01-01

Accessibility to innovative multiple myeloma therapies is limited in sub-Saharan Africa. This study aimed to describe the diagnostic and evolutionary features observed during treatment of our patients with myeloma. We conducted a retrospective, descriptive, analytical study (2005 - 2016) of patients with myeloma included in the study based on International Myeloma Working Group (IMWG) Criteria (2003,2014) at the Hopital Aristide Le Dantec (Senegal). We collected data from 136 medical records (69 men, 67 women) of patients with an average age of 59 years ± 10.1 years, who were less than 65 years of age in 69.1% of cases. Tell-tale signs included bone pain (96.3%), renal failure (36.8%), infection (23.5%), pathological fracture (17.6%), spinal cord compression (16.9%) and malignant hypercalcaemia (16.2%). Isotopic antiglobulin test showed that anti-IgG could be detected in 61.3% of cases and Kappa in 65% of cases. Patients were classified stage III (59.4%) and I-II (40.6%)of the index staging system. The median survival of patients under conventional traitement (Méphalan-Prédnisone: 67.6%, innovative: 5.9%) was 20 months (1-78 months). Survival rates are better in the absence of neurological and infectious complications and for patients with score I-II of the index Staging System. In our study, multiple myeloma was frequently diagnosed before age 65, at advanced stage of tumor mass. Early detection and access to adequate therapies could improve overall survival.

Nordic market report 2009 : Development in the Nordic electricity market

Energy Technology Data Exchange (ETDEWEB)

2009-07-01

The Nordic region is characterized by a unique mix of generation sources where the high share of hydropower, representing virtually all of the Norwegian and nearly half of the Swedish generation capacity, has a great influence on the market. The level of precipitation is thus vital when calculating and analysing potential generation levels. In addition, the Nordic region has significantly colder winters than any other European country, influencing the consumption as many households are electrically heated. In 2008 the overall electricity consumption in the Nordic region was slightly higher - 1.6 per cent - than in 2007. During periods of peak consumption the Nordic power system proved sufficient to ensure security of supply without restrictions on consumption. The Nordic region operates almost entirely as one synchronous power system through transmission grid. The continuous reinforcement of the Nordic transmission grid has enabled an increased security of supply as well as a more efficient use of the generation capacity. Increasing cross border power flows strain the transmission lines and increases the demand for transmission capacity. Possible congestions occurring between the Nord Pool bidding areas are handled through market splitting, while internal congestions in general are handled through counter trade or by reducing interconnector capacity at the bidding area borders. The Nordic wholesale power market is a well functioning electricity market. Trade at Nord Pool has increased steadily since it was established in 1993. Although trading at Nord Pool Spot is voluntary, significantly more physical power is now traded on the power exchange than bilaterally - from 42 per cent of total Nordic consumption in 2004 to 76 per cent in 2008. During 2008 average spot prices at Nord Pool were considerably higher (approximately 60 per cent) than prices in 2007. The Nordic retail markets are essentially four separate markets, influenced by national differences, but work on

Nordic market report 2009. Development in the Nordic electricity market

Energy Technology Data Exchange (ETDEWEB)

2009-07-15

The Nordic region is characterized by a unique mix of generation sources where the high share of hydropower, representing virtually all of the Norwegian and nearly half of the Swedish generation capacity, has a great influence on the market. The level of precipitation is thus vital when calculating and analysing potential generation levels. In addition, the Nordic region has significantly colder winters than any other European country, influencing the consumption as many households are electrically heated. In 2008 the overall electricity consumption in the Nordic region was slightly higher - 1.6 per cent - than in 2007. During periods of peak consumption the Nordic power system proved sufficient to ensure security of supply without restrictions on consumption. The Nordic region operates almost entirely as one synchronous power system through transmission grid. The continuous reinforcement of the Nordic transmission grid has enabled an increased security of supply as well as a more efficient use of the generation capacity. Increasing cross border power flows strain the transmission lines and increases the demand for transmission capacity. Possible congestions occurring between the Nord Pool bidding areas are handled through market splitting, while internal congestions in general are handled through counter trade or by reducing interconnector capacity at the bidding area borders. The Nordic wholesale power market is a well functioning electricity market. Trade at Nord Pool has increased steadily since it was established in 1993. Although trading at Nord Pool Spot is voluntary, significantly more physical power is now traded on the power exchange than bilaterally - from 42 per cent of total Nordic consumption in 2004 to 76 per cent in 2008. During 2008 average spot prices at Nord Pool were considerably higher (approximately 60 per cent) than prices in 2007. The Nordic retail markets are essentially four separate markets, influenced by national differences, but work on

Multiple myeloma

International Nuclear Information System (INIS)

Sohn, Jeong Ick; Ha, Choon Ho; Choi, Karp Shik

1994-01-01

Multiple myeloma is a malignant plasma cell tumor that is thought to originate proliferation of a single clone of abnormal plasma cell resulting production of a whole monoclonal paraprotein. The authors experienced a case of multiple myeloma with severe mandibular osteolytic lesions in 46-year-old female. As a result of careful analysis of clinical, radiological, histopathological features, and laboratory findings, we diagnosed it as multiple myeloma, and the following results were obtained. 1. Main clinical symptoms were intermittent dull pain on the mandibular body area, abnormal sensation of lip and pain due to the fracture on the right clavicle. 2. Laboratory findings revealed M-spike, reversed serum albumin-globulin ratio, markedly elevated ESR and hypercalcemia. 3. Radiographically, multiple osteolytic punched-out radiolucencies were evident on the skull, zygoma, jaw bones, ribs, clavicle and upper extremities. Enlarged liver and increased uptakes on the lesional sites in RN scan were also observed. 4. Histopathologically, markedly hypercellular marrow with sheets of plasmoblasts and megakaryocytes were also observed.

Consumer acceptance of the New Nordic Diet. An exploratory study

DEFF Research Database (Denmark)

Micheelsen, Arun; Holm, Lotte; Jensen, Katherine O’Doherty

2013-01-01

With direct reference to New Nordic Cuisine and Nordic dietary recommendations, the OPUS Research Centre in Denmark is developing and testing a healthy, regional New Nordic Diet (NND) that promises to have outstanding gastronomic properties. The NND is disseminated to Danish consumers with a view......, are positive towards the ideas underlying the development of this new diet and enjoy the taste and appearance of NND meals. Barriers to acceptance include the untraditional formats of NND meals, the time needed to prepare them, the unfamiliarity of ingredients, perceived problems regarding product availability...

The Nordic financial electricity market

Energy Technology Data Exchange (ETDEWEB)

2010-11-15

NordREG is a cooperation of the Nordic energy regulators. The mission is to actively promote legal and institutional framework and conditions necessary for developing the Nordic and European electricity markets. The financial market is an important market for market participants to mitigate their risks. By providing tools for risk management, the financial market contributes to the efficient functioning of both wholesale and end-user markets. NordREG decided during 2009 to undertake a study on the Nordic financial electricity market. The aim of the report is to consider whether any improvements can be made to further increase the efficiency of the Nordic financial electricity market in order to secure an optimal price setting in the wholesale and the end-user markets

Case report 383: Multiple myeloma

International Nuclear Information System (INIS)

Kouwenberg, J.J.; Simons, A.J.

1986-01-01

A unique and obviously extremely rare example of multiple myeloma has been presented, affecting the peripheral appendicular skeleton and not the hematopoietic system of the axial skeleton, radiologically and probably pathologically. Only one other similar case has been described. The radiological features were confirmed by the pathological studies: a biopsy specimen obtained from a large osteolytic lesion in a patella showed the typical stigma of multiple myeloma; a biopsy from the iliac creast showed no abnormality. (orig./SHA)

The Nordic Mobile Telecommunication Cluster

DEFF Research Database (Denmark)

Jørgensen, Ulrik

2000-01-01

A study of the historic role of the Nordic mobile telephone and telecommunications cluster and its background in both coordinated innovation policies and societal developments in Scandinavia.......A study of the historic role of the Nordic mobile telephone and telecommunications cluster and its background in both coordinated innovation policies and societal developments in Scandinavia....

Multiple Myeloma: Patient Handbook

Science.gov (United States)

... information about myeloma in a caring and compassionate man- ner. IMF InfoLine specialists can be reached at InfoLine@myeloma.org, or 800-452-CURE (2873) or 818-487-7455. Terms and definitions Albumin (ALB): Simple water-soluble protein that is ...

Multiple myeloma: diagnosis and treatment.

Science.gov (United States)

Nau, Konrad C; Lewis, William D

2008-10-01

Multiple myeloma, the most common bone malignancy, is occurring with increasing frequency in older persons. Typical symptoms are bone pain, malaise, anemia, renal insufficiency, and hypercalcemia. Incidental discovery on comprehensive laboratory panels is common. The disease is diagnosed with serum or urine protein electrophoresis or immunofixation and bone marrow aspirate analysis. Skeletal radiographs are important in staging multiple myeloma and revealing lytic lesions, vertebral compression fractures, and osteoporosis. Magnetic resonance imaging and positron emission tomography or computed tomography are emerging as useful tools in the evaluation of patients with myeloma; magnetic resonance imaging is preferred for evaluating acute spinal compression. Nuclear bone scans and dual energy x-ray absorptiometry have no role in the diagnosis and staging of myeloma. The differential diagnosis of monoclonal gammopathies includes monoclonal gammopathy of uncertain significance, smoldering (asymptomatic) and symptomatic multiple myeloma, amyloidosis, B-cell non-Hodgkin lymphoma, Waldenström macroglobulinemia, and rare plasma cell leukemia and heavy chain diseases. Patients with monoclonal gammopathy of uncertain significance or smoldering multiple myeloma should be followed closely, but not treated. Symptomatic multiple myeloma is treated with chemotherapy followed by autologous stem cell transplantation, if possible. Melphalan, prednisolone, dexamethasone, vincristine, doxorubicin, bortezomib, and thalidomide and its analogue lenalidomide have been used successfully. It is important that family physicians recognize and appropriately treat multiple myeloma complications. Bone pain is treated with opiates, bisphosphonates, radiotherapy, vertebroplasty, or kyphoplasty; nephrotoxic nonsteroidal anti-inflammatory drugs should be avoided. Hypercalcemia is treated with isotonic saline infusions, steroids, furosemide, or bisphosphonates. Because of susceptibility to infections

Nordic Noir - Location, Identity and Emotion

DEFF Research Database (Denmark)

Agger, Gunhild

2016-01-01

Understanding and discussing the impact of the Nordic element in ‘Nordic Noir’ is the main purpose of this article. This is pursued by tracing the concepts of location, identity and emotion in selected episodes of TV series and serials representative of Nordic Noir – Wallander (2005-) Forbrydelsen...... the Nordic countries traditionally see each other are therefore investigated – with Denmark and Sweden in the main roles. In terms of theory, the concept of emotions as “structures of feeling” (Raymond Williams 1978) has recently been revived, paving the way for studies of the relationship between culture...... and emotion (Sharma & Dahl 2013, Tygstrup 2013, Pribram 2011, Laine 2011). Their concepts are applied in the analyses. The article concludes with a perspective considering the role of Nordic Noir vis-à-vis international TV drama productions....

Occupation and leukemia in Nordic countries

DEFF Research Database (Denmark)

Talibov, Madar; Kautiainen, Susanna; Martinsen, Jan Ivar

2012-01-01

We studied occupational variation of the risk of acute myeloid leukemia, chronic lymphocytic leukemia, and other leukemia in Nordic countries.......We studied occupational variation of the risk of acute myeloid leukemia, chronic lymphocytic leukemia, and other leukemia in Nordic countries....

Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma

DEFF Research Database (Denmark)

Lokhorst, Henk M; Plesner, Torben; Laubach, Jacob P

2015-01-01

BACKGROUND: Multiple myeloma cells uniformly overexpress CD38. We studied daratumumab, a CD38-targeting, human IgG1κ monoclonal antibody, in a phase 1-2 trial involving patients with relapsed myeloma or relapsed myeloma that was refractory to two or more prior lines of therapy. METHODS: In part 1...... interval [CI], 4.2 to 8.1), and 65% (95% CI, 28 to 86) of the patients who had a response did not have progression at 12 months. CONCLUSIONS: Daratumumab monotherapy had a favorable safety profile and encouraging efficacy in patients with heavily pretreated and refractory myeloma. (Funded by Janssen...

The Nordic Obstetric Surveillance Study: a study of complete uterine rupture, abnormally invasive placenta, peripartum hysterectomy, and severe blood loss at delivery.

Science.gov (United States)

Colmorn, Lotte B; Petersen, Kathrine B; Jakobsson, Maija; Lindqvist, Pelle G; Klungsoyr, Kari; Källen, Karin; Bjarnadottir, Ragnheidur I; Tapper, Anna-Maija; Børdahl, Per E; Gottvall, Karin; Thurn, Lars; Gissler, Mika; Krebs, Lone; Langhoff-Roos, Jens

2015-07-01

To assess the rates and characteristics of women with complete uterine rupture, abnormally invasive placenta, peripartum hysterectomy, and severe blood loss at delivery in the Nordic countries. Prospective, Nordic collaboration. The Nordic Obstetric Surveillance Study (NOSS) collected cases of severe obstetric complications in the Nordic countries from April 2009 to August 2012. Cases were reported by clinicians at the Nordic maternity units and retrieved from medical birth registers, hospital discharge registers, and transfusion databases by using International Classification of Diseases, 10th revision codes on diagnoses and the Nordic Medico-Statistical Committee Classification of Surgical Procedure codes. Rates of the studied complications and possible risk factors among parturients in the Nordic countries. The studied complications were reported in 1019 instances among 605 362 deliveries during the study period. The reported rate of severe blood loss at delivery was 11.6/10 000 deliveries, complete uterine rupture was 5.6/10 000 deliveries, abnormally invasive placenta was 4.6/10 000 deliveries, and peripartum hysterectomy was 3.5/10 000 deliveries. Of the women, 25% had two or more complications. Women with complications were more often >35 years old, overweight, with a higher parity, and a history of cesarean delivery compared with the total population. The studied obstetric complications are rare. Uniform definitions and valid reporting are essential for international comparisons. The main risk factors include previous cesarean section. The detailed information collected in the NOSS database provides a basis for epidemiologic studies, audits, and educational activities. © 2015 Nordic Federation of Societies of Obstetrics and Gynecology.

Genome-wide association study identifies multiple susceptibility loci for multiple myeloma

DEFF Research Database (Denmark)

Mitchell, Jonathan S; Li, Ni; Weinhold, Niels

2016-01-01

Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a ...

Survey of existing studies of smart grids and consumers - Nordic countries

DEFF Research Database (Denmark)

Hansen, Meiken; Borup, Mads

2014-01-01

is on household consumers; not on industrial companies or other private or public organisations. The present report focuses on studies in the Nordic region, i.e., studies in Denmark, Finland, Iceland, Norway and Sweden. Initially this report was part of a dual delivery, where 1) focused on the Nordic countries......The objective of this survey is to map smart grid studies that address private consumers. The survey shall identify what knowledge there exists about consumer and user behaviour in connection to smart grids and, moreover, how consumers and users are approached in the studies made. The focus......; and 2) focused on selected projects in other countries. This present report is the work completed in relation to the first part....

Value of the free light chain analysis in the clinical evaluation of response in multiple myeloma patients receiving anti-myeloma therapy

DEFF Research Database (Denmark)

Toftmann Hansen, Charlotte; Pedersen, Per T.; Jensen, Bo Amdi

Value of the free light chain analysis in the clinical evaluation of response in multiple myeloma patients receiving anti-myeloma therapy.......Value of the free light chain analysis in the clinical evaluation of response in multiple myeloma patients receiving anti-myeloma therapy....

A prospective study of percutaneous vertebroplasty in patients with myeloma and spinal metastases

International Nuclear Information System (INIS)

Chew, C.; Ritchie, M.; O’Dwyer, P.J.; Edwards, R.

2011-01-01

Aim: To assess patient outcome in a consecutive series of patients with myeloma and spinal metastases who underwent percutaneous vertebroplasty. Materials and methods: Data were gathered prospectively on all patients undergoing percutaneous vertebroplasty between June 2001 and June 2010. Outcome measures included visual analogue pain scores (VAS) and Roland–Morris Questionnaire (RMQ) in patients treated since 2005 as well as complications and long-term outcome in all patients. Results: One hundred and twenty-eight patients underwent percutaneous vertebroplasty for myeloma (n = 41) or spinal metastases (n = 87) over a 9 year period. VAS scores fell from 7.75 ± 1.88 pre-vertebroplasty to 4.77 ± 2.69 post-vertebroplasty (p = 0.001). RDQ scores improved from 18.55 ± 4.79 to 13.5 ± 6.96 (p = 0.001). Complications were recorded in three patients: cement extension to vena cava (n = 1), local haematoma (n = 1), and loss of sensation over T1 dermatome (n = 1). The Kaplan–Meier estimate of 5 year survival post-vertebroplasty was 40% for patients with myeloma and 25% for those with metastases. Conclusion: This large prospective study demonstrates percutaneous vertebroplasty reduces pain and improves disability in patients from intractable pain from myeloma or spinal metastases and now forms an important part of the multimodality treatment for these patients.

The patient experience of intensive care: a meta-synthesis of Nordic studies.

Science.gov (United States)

Egerod, Ingrid; Bergbom, Ingegerd; Lindahl, Berit; Henricson, Maria; Granberg-Axell, Anetth; Storli, Sissel Lisa

2015-08-01

Sedation practices in the intensive care unit have evolved from deep sedation and paralysis toward lighter sedation and better pain management. The new paradigm of sedation has enabled early mobilization and optimized mechanical ventilator weaning. Intensive care units in the Nordic countries have been particularly close to goals of lighter or no sedation and a more humane approach to intensive care. The aim of our study was to systematically review and reinterpret newer Nordic studies of the patient experience of intensive care to obtain a contemporary description of human suffering during life-threatening illness. We conducted a meta-synthesis in which we collected, assessed, and analyzed published qualitative studies with the goal of synthesizing these findings into a new whole. Analysis was based on the scientific approach of Gadamerian hermeneutics. Nordic intensive care units. Patients in Nordic intensive care units. We performed a literature search of qualitative studies of the patient experience of intensive care based on Nordic publications in 2000-2013. We searched the following databases: PubMed, CINAHL, Scopus, and PsycINFO. Each original paper was assessed by all authors using the Critical Appraisal Skills Program instrument for qualitative research. We included 22 studies, all of which provided direct patient quotes. The overarching theme was identified as: The patient experience when existence itself is at stake. We constructed an organizing framework for analysis using the main perspectives represented in the included studies: body, mind, relationships, and ICU-environment. Final analysis and interpretation resulted in the unfolding of four themes: existing in liminality, existing in unboundedness, existing in mystery, and existing on the threshold. Our main finding was that human suffering during intensive care is still evident although sedation is lighter and the environment is more humane. Our interpretation suggested that patients with life

Obesity Prevention in the Nordic Countries.

Science.gov (United States)

Stockmarr, Anders; Hejgaard, Tatjana; Matthiessen, Jeppe

2016-06-01

Previous studies have shown that mean BMI and prevalences of overweight/obesity and obesity have increased over the last decades in the Nordic countries, despite highly regulated societies with a focus on obesity prevention. We review recent overweight/obesity and obesity prevention initiatives within four of the five Nordic countries: Sweden, Denmark, Finland, and Iceland. Moreover, we analyze the current situation based on monitoring data on BMI collected in 2011 and 2014, and obtain overall estimates of overweight/obesity and obesity prevalences for the Nordic Region. Data analysis shows that obesity in adults has increased from 2011 to 2014, while no significant changes were found for children. No significant increases were found for mean BMI and overweight/obesity prevalence. Obesity prevention initiatives among the Nordic countries are highly similar although minor differences are present, which is rooted in transnational Nordic cooperation and comparable societal structures.

Nordic Luther Research in Motion

DEFF Research Database (Denmark)

Holm, Bo Kristian

2008-01-01

Luther research in the Nordic countries is characterised by both continuation and discussion of its own legacy. Finnish Luther studies have a prominent position here, but are by no means the only actors in Nordic Luther research. Giving an overview of Nordic Luther research in the last decade......, the article selects four main topics that have been the focus of special attention: politics and ethics, Communicatio idiomatum  and Luther's view on language, Luther as preacher, and Luther and the gift. The article concludes with some comments on the continuing role of creation theology, so strongly...

The Nordic Housing Enabler

DEFF Research Database (Denmark)

Helle, Tina; Slaug, Bjørn; Brandt, Åse

2010-01-01

This study addresses development of a content valid cross-Nordic version of the Housing Enabler and investigation of its inter-rater reliability when used in occupational therapy rating situations, involving occupational therapists, clients and their home environments. The instrument was translated...... from the original Swedish version of the Housing Enabler, and adapted according to accessibility norms and guidelines for housing design in Sweden, Denmark, Finland and Iceland. This iterative process involved occupational therapists, architects, building engineers and professional translators......, resulting in the Nordic Housing Enabler. For reliability testing, the sampling strategy and data collection procedures used were the same in all countries. Twenty voluntary occupational therapists, pair-wise but independently from each other, collected data from 106 cases by means of the Nordic Housing...

Nordic Energy basics

Energy Technology Data Exchange (ETDEWEB)

Koljonen, T.; Pursiheimo, E. [VTT, Espoo (Finland)

2004-01-01

This report gives numerical data of the existing energy systems in Denmark, Finland, Island, Norway and Sweden. The data includes: 1) Primary fossil fuel production and fuel reserves; 2) Energy production and consumption; 3) Hydrogen production in the Nordic countries; 4) Energy balances of the Nordic countries. The above data has been used as background information during the Nordic H{sub 2} Energy Foresight project. The data has been collected from public literature sources and also from project partners. (au)

Nordic study on reactor waste. Technical part 1 and 2

International Nuclear Information System (INIS)

1981-08-01

An important part of the Nordic studies on system- and safety analysis of the management of low and medium level radioactive waste from nuclear power plants, is the safety analysis of a Reference System. This reference system was established within the study and is described in this Technical Part 1. The reference system covers waste management Schemes that are potential possibilities in either one of the four participating Nordic countries. The reference system is based on: a power reactor system consisting of 6 BWR's of 500 MWe each, operated simultaneously over the same 30 year period, and deep bed granular ion exchange resin wastes from the Reactor Water Clean-Up System (RWCS and powdered ion exchange resin from the Spent Fuel Pool Cleanup System (SFPCS)). Both waste types are supposed to be solidified by mixing with cement and bitumen. Two basic types of containers are considered. Standard 200 liter steel drums and specially made cubicreinforced concrete moulds with a net volume of 1 m 3 . The Nordic study assumes temporary storage of the solidified waste for a maximum of 50 years before the waste is transferred to the disposal site. Transportation of the waste from the storage facilitiy to the disposal site will be by road or sea. Three different disposal facilities are considered: Shallow land burial, near surface concrete bunker, and rock cavern with about 30 m granite cover. (EG)

Genomic predictions across Nordic Holstein and Nordic Red using the genomic best linear unbiased prediction model with different genomic relationship matrices.

Science.gov (United States)

Zhou, L; Lund, M S; Wang, Y; Su, G

2014-08-01

This study investigated genomic predictions across Nordic Holstein and Nordic Red using various genomic relationship matrices. Different sources of information, such as consistencies of linkage disequilibrium (LD) phase and marker effects, were used to construct the genomic relationship matrices (G-matrices) across these two breeds. Single-trait genomic best linear unbiased prediction (GBLUP) model and two-trait GBLUP model were used for single-breed and two-breed genomic predictions. The data included 5215 Nordic Holstein bulls and 4361 Nordic Red bulls, which was composed of three populations: Danish Red, Swedish Red and Finnish Ayrshire. The bulls were genotyped with 50 000 SNP chip. Using the two-breed predictions with a joint Nordic Holstein and Nordic Red reference population, accuracies increased slightly for all traits in Nordic Red, but only for some traits in Nordic Holstein. Among the three subpopulations of Nordic Red, accuracies increased more for Danish Red than for Swedish Red and Finnish Ayrshire. This is because closer genetic relationships exist between Danish Red and Nordic Holstein. Among Danish Red, individuals with higher genomic relationship coefficients with Nordic Holstein showed more increased accuracies in the two-breed predictions. Weighting the two-breed G-matrices by LD phase consistencies, marker effects or both did not further improve accuracies of the two-breed predictions. © 2014 Blackwell Verlag GmbH.

Cerebral metastases from multiple myeloma

International Nuclear Information System (INIS)

Norum, J.; Wist, E.; Dahl, I.M.; University Hospital, Tromsoe

1991-01-01

The authors report a patient with multiple intracerebral lesions from myeloma. The case also demonstrates that myeloma is a radiosensitive tumour and that radiotherapy is important to keep in mind when intracranial lesions are revealed. (orig.)

Introduction: multiple myeloma.

Science.gov (United States)

Cook, Richard

2008-09-01

Multiple myeloma (MM) is the most common type of primary bone tumor, affecting approximately 50,000 patients in the United States. Although it is currently not curable, recent advancements in treatment are bringing myeloma closer to becoming a chronic disease instead of a terminal illness. To better understand the prevalence of MM as well as provide an overview of the costs associated with treatment. The goals of treatment in MM include eradicating all evidence of disease, controlling disease to prevent damage to target organs, preserving normal function and quality of life, relieving pain, and managing myeloma that is in remission. To achieve these goals, treatment must be individually tailored for each patient based on the patient's age, overall health status, symptoms, and laboratory test results. Advancements in the understanding of the pathogenesis of myeloma and the role of genetic mutations are leading to a new standard of treatment. Advancements in diagnostic technology, such as cytogenetic testing, are also being used to tailor treatment for each individual to work toward achieving better response rates, longer periods of remission, and improved quality of life. Increased costs associated with the improved therapies being used to treat MM, and the comorbid conditions associated with the disease, present a challenge to managed care. Health plans and formulary decision makers need to better understand the complexity of therapy to best use resources. The economic burden to the patient must also be considered when developing treatment strategies. Better understanding of the pathophysiology of MM, including the role of cytogenetics, is leading to the development and use of novel agents and treatment options. Head-to-head studies comparing treatments must be performed to best balance the costs associated with treatment and the benefits of improved survival rates and maintaining quality of life.

Nordic cultural policies

DEFF Research Database (Denmark)

Duelund, Peter

2008-01-01

A critical view on Nordic Cultural Policy 1961-2008 - Aims, measures, forms of organisation, state og national identity......A critical view on Nordic Cultural Policy 1961-2008 - Aims, measures, forms of organisation, state og national identity...

Palliative radiotherapy for multiple myeloma

International Nuclear Information System (INIS)

Furusawa, Mitsuhiro; Baba, Yuji; Murakami, Ryuji; Yokoyama, Toshimi; Nishimura, Ryuichi; Uozumi, Hideaki; Takada, Chitose; Takahashi, Mutsumasa

1995-01-01

This study reviews the experience of palliative radiotherapy to patients with multiple myeloma to define the optimal dose for pain relief. The records of 31 patients (66 sites) with multiple myeloma irradiated for palliation at Kumamoto University hospital between 1985 and 1994 were reviewed. Total dose ranged from 8 to 50 Gy, with a mean of 32.2 Gy. Symptoms included pain (78.1%), neurological abnormalities (28.1%), and palpable masses (34.3%). Symptomatic remission was obtained in 45 of 46 evaluable sites (97.8%). Complete remission of symptoms were obtained in 28.3%, and partial remission in 69.6%. According to fraction size, there was no significant difference between 3-5 Gy and 1.8-2 Gy. The incidence of complete remission increased when a total dose of more than 20 Gy was given. When the quality of life is considered, hypofractionation was recommended for the palliative radiation therapy of multiple myeloma. (author)

Nordic Market report 2010. Development in the Nordic Electricity Market

Energy Technology Data Exchange (ETDEWEB)

2010-07-15

The Nordic region is characterized by a unique mix of generation sources, with a very high share of hydropower. Hydropower accounts for virtually all of the Norwegian and nearly half of the Swedish generation capacity, making the level of precipitation vital when calculating and analysing potential generation levels. Climatic conditions such as, significantly colder winters than any other European country also influence consumption in the Nordic region, as many households are electrically heated. Overall electricity consumption in the Nordic region in 2009 was marked by decreasing consumption in every market - from a decrease of 1,5% in Denmark to a decrease of 5,5% in Finland. The Nordic transmission grid connects almost the entire region into one synchronous power system enabling increased security of supply as well as a more efficient use of the generation capacity, but congestion occurs. Congestions between the Nord Pool bidding areas are handled through market splitting, while internal congestions in general are handled through counter trade or by reducing interconnector capacity at the bidding area borders. The key future challenge for transmission network operations both in the Nordic area, and as well on the European level will be to facilitate the functioning of the pan-European wholesale electricity markets. The Nordic wholesale power market is well functioning. The volume traded at Nord Pool in 2009 was about the same share of total consumption as that of 2008. Although trading at Nord Pool is voluntary, significantly more power is traded on the power exchange than bilaterally. During 2009 average spot prices at Nord Pool were lower than prices in 2008 due to both lower demand and generation costs for thermal power plants for most of 2009. The Nordic retail markets are essentially four separate markets, influenced by national differences, but work on integration has started. Throughout 2009 retail prices in the Nordic region were lower than in 2008

Nordic Approaches to Peace Operations (in Korean)

DEFF Research Database (Denmark)

Jakobsen, Peter Viggo

operations. First, it demolishes the widely held view that the Nordic countries remain a bastion of traditional Cold War peacekeeping with little relevance for contemporary operations. Second, it constitutes the first systematic overview of the reforms undertaken by the four Nordic countries since the end......A new examination of Nordic approaches to peace operations after the Cold War. It shows how the Nordic countries (Denmark, Finland, Norway and Sweden) remain relevant for the study and practice of post-Cold War peace operations. This unique study is structured around eleven success conditions...... derived from an analysis of the lessons learned since the early 1990s, ensuring that the results of the case studies are directly comparable. These case studies are supplemented by an analysis of Nordics’ collective efforts to replace their old Cold War peacekeeping model with a new one that meets...

Implications of Heterogeneity in Multiple Myeloma

Directory of Open Access Journals (Sweden)

Sanjay de Mel

2014-01-01

Full Text Available Multiple myeloma is the second most common hematologic malignancy in the world. Despite improvement in outcome, the disease is still incurable for most patients. However, not all myeloma are the same. With the same treatment, some patients can have very long survival whereas others can have very short survival. This suggests that there is underlying heterogeneity in myeloma. Studies over the years have revealed multiple layers of heterogeneity. First, clinical parameters such as age and tumor burden could significantly affect outcome. At the genetic level, there are also significant heterogeneity ranging for chromosome numbers, genetic translocations, and genetic mutations. At the clonal level, there appears to be significant clonal heterogeneity with multiple clones coexisting in the same patient. At the cell differentiation level, there appears to be a hierarchy of clonally related cells that have different clonogenic potential and sensitivity to therapies. These levels of complexities present challenges in terms of treatment and prognostication as well as monitoring of treatment. However, if we can clearly delineate and dissect this heterogeneity, we may also be presented with unique opportunities for precision and personalized treatment of myeloma. Some proof of concepts of such approaches has been demonstrated.

Nordic study on reactor waste

International Nuclear Information System (INIS)

1981-08-01

In 1981, 14 nuclear power reactors are in operation and 2 under construction in the Nordic countries. So far, the reactor waste originating from day-to-day operation of these plants has been stored in solidified form at the reactor sites. Within a few years a satisfactory disposal procedure needs to be established. While the main R and D effects in the waste field have earlier been devoted to the question of irradiated fuel and waste from reprocessing, there is therefore now an increased interest in reactor waste with its much lower radioactivity but somewhat larger volumes. Since 1977, efforts have been made in a joint Nordic study to examine which facts need to be known in order to perform a comprehensive safety assessment of a reactor waste management system. In the present study a Reference system related to the waste generated over 30 years from six 500 MW-reactors is examined. The dominating radionuclides during storage and transportation accident scenarios are Cs-134, Cs-137 and Co-60. For most of the release scenarios from repositories Cs-137 and Sr-90 are dominating. Some scenarios are, however, dominated by the very longlived nuclides I-129 and C-14. A closer examination of the concentration in the waste of these nuclides and of their leaching properties indicates that their small - but significant - influence, as calculated, is probably grossly overestimated. The mechanical stability obtained in routine solidification processes of reactor waste products in conjunction with the outer container (steel drum, transport container, etc.) turns out to be sufficient. Difficulties were encountered in applying ICRP methodology and available dose calculation methods to calculation of population doses due to small activity releases, and effects extending into the far future. (EG)

New Nordic comics—a question of promotion?

Directory of Open Access Journals (Sweden)

Rikke Platz Cortsen

2016-11-01

Full Text Available Throughout history, the cultures of the Nordic countries have at certain points been seen through a lense that stresses regional commonality, most recently with terms like “New Nordic Cooking” or “Nordic Noir.” In this article, we examine the possibility of a common concept of “New Nordic Comics” by analyzing a number of Nordic comics anthologies. We discuss in what way Nordic comics might be said to be new and how they can be considered to be Nordic. We state that the comics in the collections are not identifiable as particularly Nordic based on their themes or the stylistic or visual repertoires. In these respects, Nordic comics are part of a broader transnational comics culture. The comics, however, occasionally bear witness to a Nordic background or heritage, for instance, in the form of words in Finnish or the Scandinavian languages, names of characters or the milieux in the comics. On the whole, Nordicness in comics is variable and diverse, and rather than a phenomenon based on inherent quality or aesthetic commonality, new Nordic comics are a result of promotional strategies, cultural policies, and transnational connections between Nordic actors in the comics field.

Genome-wide Association Studies for Female Fertility Traits in Chinese and Nordic Holsteins.

Science.gov (United States)

Liu, Aoxing; Wang, Yachun; Sahana, Goutam; Zhang, Qin; Liu, Lin; Lund, Mogens Sandø; Su, Guosheng

2017-08-16

Reduced female fertility could cause considerable economic loss and has become a worldwide problem in the modern dairy industry. The objective of this study was to detect quantitative trait loci (QTL) for female fertility traits in Chinese and Nordic Holsteins using various strategies. First, single-trait association analyses were performed for female fertility traits in Chinese and Nordic Holsteins. Second, the SNPs with P-value Nordic Holsteins. Third, the summary statistics from single-trait association analyses were combined into meta-analyses to: (1) identify common QTL for multiple fertility traits within each Holstein population; (2) detect SNPs which were associated with a female fertility trait across two Holstein populations. A large numbers of QTL were discovered or confirmed for female fertility traits. The QTL segregating at 31.4~34.1 Mb on BTA13, 48.3~51.9 Mb on BTA23 and 34.0~37.6 Mb on BTA28 shared between Chinese and Nordic Holsteins were further ascertained using a validation approach and meta-analyses. Furthermore, multiple novel variants identified in Chinese Holsteins were validated with Nordic data as well as meta-analyses. The genes IL6R, SLC39A12, CACNB2, ZEB1, ZMIZ1 and FAM213A were concluded to be strong candidate genes for female fertility in Holsteins.

Kineziologická charakteristika Nordic Walking

OpenAIRE

Pospíšilová, Petra

2009-01-01

Title: Functional a physiological characteristics of Nordic Walking Purposes: The aim of the thesis is to describe and summarize current knowledge about Nordic Walking Methods: Literature analysis Key words: Nordic Walking, free bipedal walk, health benefits, functional indicator changes

Nordic Regional Report; Selected Issues

OpenAIRE

International Monetary Fund

2013-01-01

This Selected Issues paper elaborates findings and discussions of 2013 Cluster Consultation Nordic Regional report. The countries have close economic and financial ties and face some common challenges and shared risks, such as large banking sectors and high household debt. The economic performance of the four continental Nordic economies (Denmark, Finland, Norway, and Sweden—Nordic-4) ranks among the advanced economic development circle. It is analyzed that the large Nordic banking systems su...

The search for the white Nordic

DEFF Research Database (Denmark)

Andreassen, Rikke

2014-01-01

arrived immigrants and descendants. The article includes an analysis of Nordic race science from the turn of the twentieth century in order to illustrate how the New Nordic Kitchen draws upon a longer historical tradition of viewing the Nordic, and especially Nordic whiteness, as superior. The historical...... importance of race science in Denmark is not common knowledge, and very limited research is done in this area. The article therefore also brings new insights to the historical construction of whiteness in the Nordic context. Finally, the article also shows how the New Nordic Kitchen not only draws upon...

Nordic cooperation within natural gas research

International Nuclear Information System (INIS)

Edna, O.-J.

1993-01-01

Nordic cooperation within natural gas research is discussed. A reorganization of this cooperation has recently taken place. It is explained that common Nordic resources are now to be concentrated within 7 areas, one of which is the area of energy/industrial policies, regional policies and agriculture and forestry, all under the common heading of ''Economy''. The plan of activities within this area includes international cooperation within the European Communities, the European Energy Charter, the International Energy Agency and will involve the energy policy situation in eastern Europe and the Baltic countries, the electric power and natural gas markets in the northern countries, energy related environmental questions and Nordic energy research cooperation. Nordic research activities constitute 2% of research resources within the OECD. The basis for Nordic research cooperation (for example a common cultural background) is described, and suggestions are made as to how it should be administrated. The Nordic energy research programme for 1991-1994 embodies bioenergy and the environment, fuel cells, energy and the society, solid fuels, district heating and petroleum technology. The status report for the nordic gas market, which represents the Nordic gas companies' evaluation of the Nordic gas market, is summarized, and Nordic research activities related to gas utilization are shortly commented upon. (AB)

Bortezomib or high-dose dexamethasone for relapsed multiple myeloma

NARCIS (Netherlands)

P.G. Richardson (Paul Gerard); P. Sonneveld (Pieter); M.W. Schuster (Michael); D. Irwin (David); E.A. Stadtmauer (Edward); T. Facon (Thierry); J-L. Harousseau (Jean-Luc); D. Ben-Yehuda (Dina); S. Lonial (Sagar); H. Goldschmidt (Hartmut); D. Reece (Donna); J.F. San Miguel (Jesús Fernando); J. Bladé (Joan); M. Boccadoro (Mario); J. Cavenagh (Jamie); W. Dalton (William); A.L. Boral (Anthony); D.-L. Esseltine (Dixie-Lee); J.B. Porter (Jane); D. Schenkein (David); K.C. Anderson (Kenneth)

2005-01-01

textabstractBACKGROUND: This study compared bortezomib with high-dose dexamethasone in patients with relapsed multiple myeloma who had received one to three previous therapies. METHODS: We randomly assigned 669 patients with relapsed myeloma to receive either an intravenous bolus of bortezomib (1.3

Report from the European myeloma network on interphase FISH in multiple myeloma and related disorders

NARCIS (Netherlands)

F. Ross (F.); H. Avet-Loiseau; G. Ameye (Geneviève); N. Gutierrez (Norma); G. Liebisch (Gerhard); S. O'Connor (Sheila); K. Dalva (Klara); F. Fabris (Federica Margherita); A.M. Testi (Adele); M. Jarosova (M.); C. Hodkinson (Clare); A. Collin (Anna); G. Kerndrup (Gitte); P. Kuglik (Petr); D. Ladon (Dariusz); P. Bernasconi (Paolo); B. Maes (Bart); Z. Zemanova (Zuzana); K. Michalova (Kyra); L. Michau (Lucienne); K. Neben (Kai); N.E.U. Hermansen (N. Emil); K. Rack (Katrina); A. Rocci (Alberto); R. Protheroe (Rebecca); L. Chiecchio (Laura); H.A. Poirel (Hélène A); P. Sonneveld (Pieter); M. Nyegaard (M.); H.E. Johnsen (Hans)

2012-01-01

textabstractThe European Myeloma Network has organized two workshops on fluorescence in situ hybridization in multiple myeloma. The first aimed to identify specific indications and consensus technical approaches of current practice. A second workshop followed a quality control exercise in which 21

Obesity Prevention in the Nordic Countries

DEFF Research Database (Denmark)

Stockmarr, Anders; Hejgaard, Tatjana; Matthiessen, Jeppe

2016-01-01

Previous studies have shown that mean BMI and prevalences of overweight/obesity and obesity have increased over the last decades in the Nordic countries, despite highly regulated societies with a focus on obesity prevention. We review recent overweight/obesity and obesity prevention initiatives...... that obesity in adults has increased from 2011 to 2014, while no significant changes were found for children. No significant increases were found for mean BMI and overweight/obesity prevalence. Obesity prevention initiatives among the Nordic countries are highly similar although minor differences are present...... within four of the five Nordic countries: Sweden, Denmark, Finland, and Iceland. Moreover, we analyze the current situation based on monitoring data on BMI collected in 2011 and 2014, and obtain overall estimates of overweight/obesity and obesity prevalences for the Nordic Region. Data analysis shows...

Therapeutic advancements in multiple myeloma

Directory of Open Access Journals (Sweden)

Alessandro eGozzetti

2014-09-01

Full Text Available Multiple myeloma survival has significantly improved in latest years, due to a broad spectrum of novel agents available for treatment. The introduction of thalidomide, bortezomib and lenalidomide together with autologous stem cell transplantation has dramatically prolonged complete remissions rate, progression free survivals resulting ultimately in prolonged survivals in myeloma patients. Moreover, novel strategies of treatment such as consolidation and maintenance are being used to implement responses. A number of new drugs such as carfilzomib and pomalidomide are already in clinical practice, and new kids on the block are entering, making the future of myeloma patients brighter.

Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma

Science.gov (United States)

Yang, Jing; He, Jin; Wang, Ji; Cao, Yabing; Ling, Jianhua; Qian, Jianfei; Lu, Yong; Li, Haiyan; Zheng, Yuhuan; Lan, Yongsheng; Hong, Sungyoul; Matthews, Jairo; Starbuck, Michael W; Navone, Nora M; Orlowski, Robert Z.; Lin, Pei; Kwak, Larry W.; Yi, Qing

2012-01-01

Bone destruction is a hallmark of multiple myeloma and affects more than 80% of patients. However, current therapy is unable to completely cure and/or prevent bone lesions. Although it is accepted that myeloma cells mediate bone destruction by inhibition of osteoblasts and activation of osteoclasts, the underlying mechanism is still poorly understood. This study demonstrates that constitutive activation of p38 mitogen-activated protein kinase in myeloma cells is responsible for myeloma-induced osteolysis. Our results show that p38 is constitutively activated in most myeloma cell lines and primary myeloma cells from patients. Myeloma cells with high/detectable p38 activity, but not those with low/undetectable p38 activity, injected into SCID or SCID-hu mice caused bone destruction. Inhibition or knockdown of p38 in human myeloma reduced or prevented myeloma-induced osteolytic bone lesions without affecting tumor growth, survival, or homing to bone. Mechanistic studies showed that myeloma cell p38 activity inhibited osteoblastogenesis and bone formation and activated osteoclastogenesis and bone resorption in myeloma-bearing SCID mice. This study elucidates a novel molecular mechanism—sactivation of p38 signaling in myeloma cells—by which myeloma cells induce osteolytic bone lesions and indicates that targeting myeloma cell p38 may be a viable approach to treating or preventing myeloma bone disease. PMID:22425892

PET/CT and MR imaging in myeloma

Energy Technology Data Exchange (ETDEWEB)

Mulligan, Michael E. [University of Maryland Medical Center, Department of Radiology, Baltimore, MD (United States); Badros, Ashraf Z. [University of Maryland, Department of Medicine, Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD (United States)

2007-01-15

Myeloma is the most common primary bone malignancy. It accounts for 10% of all hematological malignancies and 1% of all cancers. In the United States, there are an estimated 16,000 new cases and over 11,000 deaths yearly due to myeloma. Plasma cell dyscrasias manifest themselves in a variety of forms that range from MGUS (monoclonal gammopathy of undetermined significance) and smoldering myeloma that require no therapy, to the ''malignant'' form of multiple myeloma. The role of imaging in the management of myeloma includes: an assessment of the extent of intramedullary bone disease, detection of any extramedullary foci, and severity of the disease at presentation; the identification and characterization of complications; subsequent assessment of disease status. This review will focus on the use of PET/CT and MR imaging for myeloma patients at the time of initial diagnosis and for follow-up management, based on current reports in the literature and our practice at the Marlene and Stewart Greenebaum Cancer Center, University of Maryland Medical Center in Baltimore, USA. (orig.)

Histone deacetylase inhibitors in multiple myeloma

Directory of Open Access Journals (Sweden)

Sarah Deleu

2009-06-01

Full Text Available Novel drugs such as bortezomib and high dose chemotherapy combined with stem cell transplantation improved the outcome of multiple myeloma patients in the past decade. However, multiple myeloma often remains incurable due to the development of drug resistance governed by the bone marrow micro-environment. Therefore targeting new pathways to overcome this resistance is needed. Histone deacetylase (HDAC inhibitors represent a new class of anti-myeloma agents. Inhibiting HDACs results in histone hyperacetylation and alterations in chromatine structure, which, in turn, cause growth arrest differentiation and/or apoptosis in several tumor cells. Here we summarize the molecular actions of HDACi as a single agent or in combination with other drugs in different in vitro and in vivo myeloma models and in (preclinical trials.

A concise revised myeloma comorbidity index as a valid prognostic instrument in a large cohort of 801 multiple myeloma patients

NARCIS (Netherlands)

M. Engelhardt (Monika); Domm, A.-S. (Anne-Saskia); Dold, S.M. (Sandra Maria); G. Ihorst (Gabriele); Reinhardt, H. (Heike); Zober, A. (Alexander); Hieke, S. (Stefanie); Baayen, C. (Corine); Müller, S.J. (Stefan Jürgen); H. Einsele (Hermann); P. Sonneveld (Pieter); O. Landgren; M. Schumacher (M.); R. Wäsch (Ralph)

2017-01-01

textabstractWith growing numbers of elderly multiple myeloma patients, reliable tools to assess their vulnerability are required. The objective of the analysis herein was to develop and validate an easy to use myeloma risk score (revised Myeloma Comorbidity Index) that allows for risk prediction of

Green Nanotechnology in Nordic Construction - Eco-innovation strategies and Dynamics in nordic Window Chains

DEFF Research Database (Denmark)

Andersen, Maj Munch; Sandén, Björn A.; Palmberg, Christopher

This project analyzes Nordic trends in the development and industrial uptake of green nanotechno-logy in construction. The project applies an evolutionary economic perspective in analyzing the innovation dynamics and firm strategies in the window value chains in three Nordic countries, Denmark......, Finland and Sweden. Hence the project investigates two pervasive parallel market trends: The emergence of the green market and the emergence of nanotechnology. The analysis investigates how a traditional economic sector such as the construction sector reacts to such major trends. Conclusions are multiple...... of nanotechnology in the construction sector in the Nordic countries we do find quite a high number of nanotech applications in the Nordic window chains. Eco-innovation is influencing strongly on the nanotech development. We see several examples of nano-enabled smart, multifunctional green solutions in the Nordic...

Challenges to Nordic Police Research

DEFF Research Database (Denmark)

Holmberg, Lars

2015-01-01

The paper will cover three main points: A short description of published police research in the Nordic countries; a somewhat longer discussion of the nature of, and challenges to, Nordic police research and, finally, a critique of the homeliness of research.......The paper will cover three main points: A short description of published police research in the Nordic countries; a somewhat longer discussion of the nature of, and challenges to, Nordic police research and, finally, a critique of the homeliness of research....

Geriatric work-up in the Nordic countries. The Nordic approach to comprehensive geriatric assessment

DEFF Research Database (Denmark)

Sletvold, O; Tilvis, R; Jonsson, A

1996-01-01

A group established by the Nordic professors of geriatrics has developed a position document presenting a shared and updated review of geriatric work-up as a way of comprehensive geriatric assessment in the Nordic countries. The main intention is that the document will serve as support and help f...... languages, and the translated versions should ideally have been subjected to validity and reliability testing. However, so far no scale meets these demands regarding all the five Nordic languages.......A group established by the Nordic professors of geriatrics has developed a position document presenting a shared and updated review of geriatric work-up as a way of comprehensive geriatric assessment in the Nordic countries. The main intention is that the document will serve as support and help...... for the clinician concerned with hospital based geriatric medicine. It may also be useful for quality control and teaching. Not least, it may be useful for health professionals other than geriatricians. To some extent, the position of geriatric medicine in the Nordic countries varies between the countries. However...

A temporal study on #betta#2-microglobulin as marker for diagnosis and monitoring of multiple myeloma

International Nuclear Information System (INIS)

Neri, B.

1982-01-01

The most important objective carried on, in the field of oncology has been the finding of new means to improve diagnosis and monitoring of neoplastic diseases. So we have chronobiologically studied the behaviour of #betta# 2 -microglobulin, in three groups of patients: Group A: 11 healthy subjects; Group B: 11 untreated patients with multiple myeloma and Group C: 11 multiple myeloma patients, after treatment with polychemoterapy. #betta# 2 -microglobulin, was assayed in serum obtained at six consecutive 4-hourly intervals, by radioimmunoassay, the levels and the various rhythm parameters were analyzed by ''Group mean cosinor'' test. The data suggest, that a circadian rhythm for #betta# 2 -microglobulin in the three groups is not detectable; but ''mesor test'' establishes significant differences (p 2 -microglobulin, in diagnosis and monitoring of multiple myeloma, is suggested

Multiple myeloma: 45 cases

International Nuclear Information System (INIS)

Yang, Hee Chul; Suh, Jin Suck; Park, Chang Yun

1990-01-01

We evaluated 45 cases of multiple myelomas retrospectively confirmed in Severance Hospital from the period of 1983-1989. In order to assess the radiologic features of the multiple myeloma and to assist in possible early diagnosis and treatment. The result were as follows: 1. IgG(41%) was the most common immunoglobulin type secreted followed by light chain(36%). IgA(19%) and IgD(2%). Two percent of the patients had non-secretory type. 89% of patients were in their stage III of the disease. 2. Among the 45 patients, 96% had abnormal plain radiographic findings with average number of 4.5 lesions. Common sites were the spine, rib, skull, pelvis, and humerus in descending orders. The findings were localized or diffuse osteolytic bone destruction(85%). osteoporosis(49%), pathologic fracture and endosteal scalloping(55%). Osteoporosis was more prominent in stage III than stage II. 3. Both plain X-ray and radioisotope study was available for comparison in 28 patients. Concordance between the two studies were 44%, lesions detected only on plain X-ray film were 51%, and lesions detected only on the radioisotope were 5%. The plain radiography was able to detect only 54% of bone lesions confirmed by bone marrow biopsy. With the above results, accurate evaluation of bone lesions in multiple myeloma may be difficult with radiologic studies only. But familiarity with these radiologic findings of the this disease entity is necessary for early suspicion of the disease, thus for early diagnosis and treatment

Nordic Management and Sustainable Business

DEFF Research Database (Denmark)

Preuss, Bjørn

2017-01-01

of the Nordics and from that wants to answer if this management approach fosters a sustainable business culture. For defining the management and cultural approach applied in Nordic companies, the method of text mining in relation with machine learning will be used. Among European companies, the Nordic companies...

Osteoclast nuclei of myeloma patients show chromosome translocations specific for the myeloma cell clone: a new type of cancer-host partnership?

DEFF Research Database (Denmark)

Levin Andersen, Thomas; Boissy, Patrice; Sondergaard, T E

2007-01-01

through fusion between myeloma cells and osteoclasts. In conclusion, malignant cells contribute significantly to the formation of bone-resorbing osteoclasts in multiple myeloma. Osteoclast-myeloma clone hybrids reflect a previously unrecognized mechanism of bone destruction in which malignant cells...

Nordic Landscape

DEFF Research Database (Denmark)

Hjortshøj, Rasmus

2017-01-01

This Box Set NORDIC LANDSCAPE presents Nordic Territories, a project by Rasmus Hjortshøj, exploring the man-made landscapes of the coastal territories and the entanglement of society and nature in times where it is no longer merely mankind subjected to nature, but where nature is equally being...... territories is not only their transient nature, but also the warm currents of the Gulf Stream making these northern shorelines habitable for human settlements....

CISG Nordic

DEFF Research Database (Denmark)

2013-01-01

CISG Nordic er en forskningsdatabase hvor den seneste information om den internationale købelovs anvendelse i de Nordiske lande offentliggøres. På hjemmesiden indgår retsafgørelser, bibliografiske noter, FN dokumenter m.m.......CISG Nordic er en forskningsdatabase hvor den seneste information om den internationale købelovs anvendelse i de Nordiske lande offentliggøres. På hjemmesiden indgår retsafgørelser, bibliografiske noter, FN dokumenter m.m....

CISG Nordic

DEFF Research Database (Denmark)

2010-01-01

CISG Nordic er en forskningsdatabase hvor den seneste information om den internationale købelovs anvendelse i de Nordiske lande offentliggøres. På hjemmesiden indgår retsafgørelser, bibliografiske noter, FN dokumenter m.m.......CISG Nordic er en forskningsdatabase hvor den seneste information om den internationale købelovs anvendelse i de Nordiske lande offentliggøres. På hjemmesiden indgår retsafgørelser, bibliografiske noter, FN dokumenter m.m....

Proceedings of the 1st Nordic Optimization Symposium - 10th Nordic MPS meeting, Copenhagen 2006

DEFF Research Database (Denmark)

Clausen, Jens; Jørgensen, Rene Munk; Kohl, Niklas

2006-01-01

, Operations Research and Mathematical Programming. Finally we would like to thank our sponsors and supporter for their contributions. It has among other things made it possible to give free registration to a number of researchers from the Baltic countries and Ph.D. students in general. We wish you all......On behalf of the Technical University of Denmark, the Danish Operations Research Society and the Nordic Section of the Mathematical Programming Society we welcome you to Copenhagen and the 1st Nordic Optimization Symposium - the 10th meeting of the Nordic MPS. The meetings of the Nordic MPS have...... to add a new title, that reflects the much broader field that is our playground at these meetings. Still the odd trustworthy title “Meeting of the Nordic MPS” has been maintained to demonstrate the origin of the symposium. It is our hope that future Nordic MPS meetings will carry on using this “double...

Targeting paraprotein biosynthesis for non-invasive characterization of myeloma biology.

Directory of Open Access Journals (Sweden)

Katharina Lückerath

Full Text Available PURPOSE: Multiple myeloma is a hematologic malignancy originating from clonal plasma cells. Despite effective therapies, outcomes are highly variable suggesting marked disease heterogeneity. The role of functional imaging for therapeutic management of myeloma, such as positron emission tomography with 2-deoxy-2-[¹⁸F]fluoro-D-glucose (¹⁸F-FDG-PET, remains to be determined. Although some studies already suggested a prognostic value of ¹⁸F-FDG-PET, more specific tracers addressing hallmarks of myeloma biology, e.g. paraprotein biosynthesis, are needed. This study evaluated the amino acid tracers L-methyl-[¹¹C]-methionine (¹¹C-MET and [¹⁸F]-fluoroethyl-L-tyrosine ((¹⁸F-Fet for their potential to image myeloma and to characterize tumor heterogeneity. EXPERIMENTAL DESIGN: To study the utility of ¹¹C-MET, ¹⁸F-Fet and ¹⁸F-FDG for myeloma imaging, time activity curves were compared in various human myeloma cell lines (INA-6, MM1.S, OPM-2 and correlated to cell-biological characteristics, such as marker gene expression and immunoglobulin levels. Likewise, patient-derived CD138⁺ plasma cells were characterized regarding uptake and biomedical features. RESULTS: Using myeloma cell lines and patient-derived CD138⁺ plasma cells, we found that the relative uptake of ¹¹C-MET exceeds that of ¹⁸F-FDG 1.5- to 5-fold and that of ¹⁸F-Fet 7- to 20-fold. Importantly, ¹¹C-MET uptake significantly differed between cell types associated with worse prognosis (e.g. t(4;14 in OPM-2 cells and indolent ones and correlated with intracellular immunoglobulin light chain and cell surface CD138 and CXCR4 levels. Direct comparison of radiotracer uptake in primary samples further validated the superiority of ¹¹C-MET. CONCLUSION: These data suggest that ¹¹C-MET might be a versatile biomarker for myeloma superior to routine functional imaging with ¹⁸F-FDG regarding diagnosis, risk stratification, prognosis and discrimination of tumor

A murine model of human myeloma bone disease

NARCIS (Netherlands)

Garrett, I.R.; Dallas, S.; Radl, J.; Mundy, G.R.

1997-01-01

Myeloma causes a devastating and unique form of osteolytic bone disease. Although osteoclast activation is responsible for bone destruction, the precise mechanisms by which myeloma cells increase osteoclast activity have not been defined. An animal model of human myeloma bone disease mould help in

New Genetic Insights and Therapy in Multiple Myeloma

NARCIS (Netherlands)

K.L. Wu

2007-01-01

textabstractIn the last decade, several significant advances in myeloma therapy have occurred with the pace of change accelerated with the introduction of new anti-myeloma agents. The approach to the treatment of multiple myeloma has become more complex with an array of therapeutic options,

On Russian/Nordic Investment Competition in the Baltic States

Directory of Open Access Journals (Sweden)

Olenchenko Vladimir

2015-06-01

Full Text Available The researchers often overlook the relationships between Russian and Nordic investment capital; and even less attention is paid to studying the competition between the two. Yet this subject can be of particular relevance to the areas that are geographically, historically and culturally close to both Russia and the Nordic countries. Thus, the aim of this article is to understand how the competition between Russian and Nordic capital investment is played out in the Baltic States. The study discusses the principles of Russian and Nordic investment in the Baltic, and suggests ways to regulate these relations. To this end, we compare the investment conditions created in the Baltic States for both Russian and Nordic investors. The analysis shows that most of the Baltic market is controlled by the Nordic capital, which blocks the arrival of Russian investment to the Baltic States. With a nod to a number of previous studies, the authors of this article suggest some adjustments to the theory of foreign direct investment. The study will be also of practical interest to those Russian investors who are seeking entry points to the Baltic markets.

Multiple myeloma with extramedullary disease.

Science.gov (United States)

Oriol, Albert

2011-11-01

Plasmacytoma is a tumor mass consisting of atypical plasma cells. Incidence of plasmacytomas associated with multiple myeloma range from 7% to 17% at diagnosis and from 6% to 20% during the course of the disease. In both situations, occurrence of extramedullary disease has been consistently associated with a poorer prognosis of myeloma. Extramedullary relapse or progression occurs in a variety of clinical circumstances and settings, and therefore requires individualization of treatment. Alkylating agents, bortezomib, and immunomodulatory drugs, along with corticoids, have been used to treat extramedullary relapse but, because of the relatively low frequency or detection rate of extramedullary relapse, no efficacy data are available from controlled studies in this setting.

Noninvasive imaging of multiple myeloma using near infrared fluorescent molecular probe

Science.gov (United States)

Hathi, Deep; Zhou, Haiying; Bollerman-Nowlis, Alex; Shokeen, Monica; Akers, Walter J.

2016-03-01

Multiple myeloma is a plasma cell malignancy characterized by monoclonal gammopathy and osteolytic bone lesions. Multiple myeloma is most commonly diagnosed in late disease stages, presenting with pathologic fracture. Early diagnosis and monitoring of disease status may improve quality of life and long-term survival for multiple myeloma patients from what is now a devastating and fatal disease. We have developed a near-infrared targeted fluorescent molecular probe with high affinity to the α4β1 integrin receptor (VLA-4)overexpressed by a majority of multiple myeloma cells as a non-radioactive analog to PET/CT tracer currently being developed for human diagnostics. A near-infrared dye that emits about 700 nm was conjugated to a high affinity peptidomimmetic. Binding affinity and specificity for multiple myeloma cells was investigated in vitro by tissue staining and flow cytometry. After demonstration of sensitivity and specificity, preclinical optical imaging studies were performed to evaluate tumor specificity in murine subcutaneous and metastatic multiple myeloma models. The VLA-4-targeted molecular probe showed high affinity for subcutaneous MM tumor xenografts. Importantly, tumor cells specific accumulation in the bone marrow of metastatic multiple myeloma correlated with GFP signal from transfected cells. Ex vivo flow cytometry of tumor tissue and bone marrow further corroborated in vivo imaging data, demonstrating the specificity of the novel agent and potential for quantitative imaging of multiple myeloma burden in these models.

[IgE myeloma. Laboratory typing difficulties].

Science.gov (United States)

Bovone, Nora S; Fuente, María Cristina; Gastiazoro, Ana María; Alfonso, Graciela; Freitas, María Josefina

2014-01-01

The IgE multiple myeloma is a rare neoplasm of plasma cell accounting for 0.01% of all plasma cell dyscrasias. They are generally of more aggressive development and to date there are no more than 50 cases published in current literature. Laboratory studies are, in these cases, essential for the classification of the monoclonal component in serum and urine. The aim of this presentation is to report a patient diagnosed with IgE myeloma and to point out that the laboratory difficulties noted in these rare cases can lead to an erroneous report.

[Association of Kaposi sarcoma--multiple myeloma. A new case].

Science.gov (United States)

Cohen, J D; Thomas, E; Garnier, N; Hellier, I; Durand, L; Guilhou, J J; Baldet, P; Blotman, F

2000-11-01

Kaposi's disease is an angiogenic multifocal cancer process that has several forms, namely Mediterranean, African, HIV-associated, and secondary to a preexisting immunodepressive state (hematological disorder, corticosteroid therapy, immunodepressive treatment). Whatever its form, Kaposi's sarcoma is probably associated with a chronic viral human herpes type 8 infection (HHV8). This virus has been implicated in the pathogenesis of multiple myeloma (17 cases recorded to date). In the present study, a further case of Kaposi's sarcoma associated with multiple myeloma has been reported. However, Epstein-Barr virus, cytomegalovirus, hepatitis B and C, HIV and HHV8 serologies were negative. Radiotherapy on the lower limbs was initiated. It is concluded that HHV8 does not appear to play a pathogenic role in cases of multiple myeloma, given the rarity of the association between Kaposi's sarcoma/multiple myeloma/HHV8.

Renal complications in multiple myeloma and related disorders: survivorship care plan of the International Myeloma Foundation Nurse Leadership Board.

Science.gov (United States)

Faiman, Beth M; Mangan, Patricia; Spong, Jacy; Tariman, Joseph D

2011-08-01

Kidney dysfunction is a common clinical feature of symptomatic multiple myeloma. Some degree of renal insufficiency or renal failure is present at diagnosis or will occur during the course of the disease and, if not reversed, will adversely affect overall survival and quality of life. Chronic insults to the kidneys from other illnesses, treatment, or multiple myeloma itself can further damage renal function and increase the risk for additional complications, such as anemia. Patients with multiple myeloma who have light chain (Bence Jones protein) proteinuria may experience renal failure or progress to end-stage renal disease (ESRD) and require dialysis because of light chain cast nephropathy. Kidney failure in patients with presumed multiple myeloma also may result from amyloidosis, light chain deposition disease, or acute tubular necrosis caused by nephrotoxic agents; therefore, identification of patients at risk for kidney damage is essential. The International Myeloma Foundation's Nurse Leadership Board has developed practice recommendations for screening renal function, identifying positive and negative contributing risk and environmental factors, selecting appropriate therapies and supportive care measures to decrease progression to ESRD, and enacting dialysis to reduce and manage renal complications in patients with multiple myeloma.

Nordic Mediation - Comparing Denmark and Finland

DEFF Research Database (Denmark)

Lappi-Seppälä, Tapio; Storgaard, Anette

2015-01-01

The Nordic Countries have a long common history in criminal policy but a closer look also indicates individual Development. the introduction of Victim Offender Mediation is one example of Nordic diversity in details.......The Nordic Countries have a long common history in criminal policy but a closer look also indicates individual Development. the introduction of Victim Offender Mediation is one example of Nordic diversity in details....

Myeloma: Patient accounts of their pathways to diagnosis

Science.gov (United States)

Hart, Ruth I.; Smith, Alexandra G.; Macleod, Una; Patmore, Russell; Cook, Gordon; Roman, Eve

2018-01-01

Background Pathways to myeloma diagnosis can be prolonged, and are often preceded by multiple GP consultations and emergency presentation. This is the first qualitative study to examine events leading to diagnosis by asking patients about their experiences during this time. Methods Set within a UK population-based cohort, semi-structured interviews were conducted with 20 myeloma patients with varying characteristics and pathways, 12 of whom invited their relatives to take part. Interviews were audio-recorded and qualitative analysis undertaken. Results Pre-diagnostic awareness of myeloma was minimal. Disease onset was typically described as gradual, and health changes vague but progressive, with increasing loss of function. A wide range of symptoms was reported, with the similarity of these to self-limiting conditions failing to raise suspicion of myeloma among patients and GPs. Patients tended to normalise symptoms at first, although all eventually sought GP advice. GPs often initially suggested benign diagnoses, which were sometimes only revised after multiple consultations with persistent/worsening symptoms. Referrals were made to various hospital specialities, and haematology if associated with abnormal blood tests suggestive of myeloma. Once in secondary care, progress towards diagnosis was generally rapid. Conclusions Accounts confirmed that pathways to diagnosis could be difficult, largely due to the way myeloma presents, and how symptoms are interpreted and managed by patients and GPs. Recognition of ‘normal’ health and consultation patterns for the individual could promote appropriate help-seeking and timely referral when changes occur, and may be more effective than raising awareness about the myriad of potential symptoms associated with this disease. PMID:29617390

Green nanotechnology in Nordic Construction: Eco-innovation strategies and Dynamics in Nordic Window Value Chains

DEFF Research Database (Denmark)

Andersen, Maj Munch

2010-01-01

This project analyzes Nordic trends in the development and industrial uptake of green nanotechno-logy in construction. The project applies an evolutionary economic perspective in analyzing the innovation dynamics and firm strategies in the window value chains in three Nordic countries, Denmark......, Finland and Sweden. Hence the project investigates two pervasive parallel market trends: The emergence of the green market and the emergence of nanotechnology. The analysis investigates how a traditional economic sector such as the construction sector reacts to such major trends. Conclusions are multiple...... of nanotechnology in the construction sector in the Nordic countries we do find quite a high number of nanotech applications in the Nordic window chains. Eco-innovation is influencing strongly on the nanotech development. We see several examples of nano-enabled smart, multifunctional green solutions in the Nordic...

Cross-Border Collaboration in History among Nordic Students: A Case Study about Creating Innovative ICT Didactic Models

Science.gov (United States)

Spante, Maria; Karlsen, Asgjerd Vea; Nortvig, Anne-Mette; Christiansen, Rene B.

2014-01-01

Gränsöverskridande Nordisk Undervisning/Utdanelse (GNU, meaning Cross-Border Nordic Education), the larger Nordic project, under which this case study was carried out, aims at developing innovative, cross-border teaching models in different subject domains in elementary school, including mathematics, language, science, social studies and history.…

Targeted Therapies for Myeloma and Metastatic Bone Cancers

Science.gov (United States)

2010-09-01

Cancer J Clin 2003; 53:5. Kasugai S, Fujisawa R, Waki Y, Miyamoto K, Ohya K 2000 Selective drug delivery system to bone: small peptide (Asp)6...page. Bone targeted nanoparticles , bone cancer myeloma, mice studies, PLGA , Biodegradable materials. Targeted Therapies for Myeloma and Metastatic Bone...present results from this program at talk at the Particles 2006 –Medical/Biochemical Diagnostic , Pharmaceutical, and Drug Delivery . 3

Nordic Energy Policy Cooperation

DEFF Research Database (Denmark)

Jørgensen, Birte Holst

2016-01-01

Brundtland Commission Report, and climate change became a common concern. Energy technology cooperation was an integral part of Nordic energy policy cooperation from the very beginning. The Nordic Energy Research Programme was established with funding from each of the Nordic countries, and was earmarked...... by a committee of senior officials and a secretariat. This was characterised by an incremental development of the cooperation based on consensus, mutual understanding and trust facilitated through exchange of experiences, work groups, seminars, educational activities and mobility schemes for energy policy...

CARs in the Lead Against Multiple Myeloma

DEFF Research Database (Denmark)

Ormhøj, Maria; Bedoya, Felipe; Frigault, Matthew J.

2017-01-01

The recent clinical success of CD19-directed chimeric antigen receptor (CAR) T cell therapy in chronic and acute leukemia has led to increased interest in broadening this technology to other hematological malignancies and solid tumors. Now, advances are being made using CAR T cell technology...... to target myeloma antigens such as B cell maturation antigen (BCMA), CD138, and kappa-light chain as well as CD19 on putative myeloma stem cells. To date, only a limited number of multiple myeloma patients have received CAR T cell therapy but preliminary results have been encouraging. In this review, we...... summarize the recently reported results of clinical trials conducted utilizing CAR T cell therapy in multiple myeloma (MM)....

Challenges to nordic teacher education programmes

DEFF Research Database (Denmark)

Rasmussen, Jens; Dorf, Hans

2010-01-01

and subjects in the Finnish teacher education program (pedagogical studies, quality of practice teaching, research base) and its strong focus on training future teachers for the teacher profession and a professional community play an important role in respect to recruitment and low drop-out rates.......  This article resumes a comparative study on the Nordic teacher education programs in Denmark, Finland, Iceland, Norway and Sweden (Nordisk Ministerråd/Nordic Council of Ministers, 2008). By focusing on the part of the study which is occupied with the structure and organisation of the Nordic...... teacher education programs it tries to find explanations for the fact that only the Finnish teacher education does not suffer from a decreasing number of applicants, from high drop-out rates, and from low retention rates. It is claimed that the strong emphasis on specific professional elements...

Multiple myeloma.

LENUS (Irish Health Repository)

Collins, Conor D

2012-02-01

Advances in the imaging and treatment of multiple myeloma have occurred over the past decade. This article summarises the current status and highlights how an understanding of both is necessary for optimum management.

Particularities of the Nordic

DEFF Research Database (Denmark)

Siim, Birte; Stoltz, Pauline

2015-01-01

The Nordic countries are in international rankings included as some of the most gender equal societies in the world (see e.g. the Global Gender Gap Index and the Gender Equality Index developed by the European Gender Equality Institute, EIGE), and scholars have demonstrated that the discourse...... and politics of women’s rights and gender equality has become an intrinsic part of the Nordic national identities and politics of belongings (Gullestad 2006). In spite of these achievements, Nordic scholars suggest that the increasing impact of globalization present major challenges for addressing multiple...... inequalities in power and resources (Melby et.al. 2008; Siim and Skjeie 2008). The chapter aims to analyse the challenge from globalization to the Nordic welfare and gender regimes and discuss the potentials and limits of this approach to equality from historical and comparative perspectives. The main research...

The Wage Curve in the Nordic Countries

DEFF Research Database (Denmark)

Madsen, Erik Strøjer; Albæk, K.; Asplund, R.

regions in the long run. One explanation put forward for this slow speed of regional wage adjustment is the rather centralized bargaining system on the labour market in the Nordic countries. Wages are set according to the average unemployment rate for the economy as a whole, and differences in regional...... for researchers or civil servants with a deeper interest in labour market problems. The main result from this study is that the wage formation at the regional level is rather inflexible in the short run in all five Nordic countries, with no effect from changes in local unemployment on the local wage level......This report focusses on wage formation in the Nordic countries with a special attention to the effect from changes in local unemployment on the local wage level. The book gives a comprehensive and comparable study of this topic in the five Nordic countries which may be of great value...

Nuclear threats in the vicinity of the Nordic countries

International Nuclear Information System (INIS)

Eikelmann, I.M.H.; Moeller, B.

1999-01-01

This project is one of the new cross-disciplinary studies in the NKS (Nordic Nuclear Safety) research program 1998-2001. The main task for the project is to aggregate knowledge of nuclear threats in the vicinity of the Nordic countries, a 'base of knowledge', and make this available for the Nordic authorities as a supplement for the national emergency preparedness work. The project will focus on potential events in nuclear installations and the consequences for the Nordic countries especially on: vulnerable food chains; doses to man; environmental contamination; the emergency preparedness system. (au)

Abnormal radiological features in a multiple myeloma patient: a case report and radiological review of myelomas

DEFF Research Database (Denmark)

Ghosh, Sujoy; Wadhwa, P; A, Kumar

2011-01-01

and porotic changes. Primary sclerotic manifestations are rare and occur in only 3% of cases. Although exceptional, multiple myeloma must be borne in mind in the presence of bone sclerosis. This report presents a patient with multiple myeloma with a sunburst/hair-on-end pattern on the radiograph and sclerotic...

Evaluation of anticancer effects of a novel proteasome inhibitor (Velcade), interferon (alpha-interferon) and anti myeloma antibodies on the growth of myeloma cells

International Nuclear Information System (INIS)

El shershaby, H.M.M.

2013-01-01

Cancer is an abnormal growth of cells caused by multiple changes in gene expression leading to deregulated balance of cell proliferation and cell death and ultimately evolving into a population of cells that can invade tissues and metastasize to distant sites, causing significant morbidity. Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells in the bone marrow leading to impaired hematopoiesis and bone diseases, which includes mainly lytic lesions, pathological fractures, hypercalcaemia and osteoporosis. Chemotherapy is the systemic treatment of cancer with anticancer drugs. Chemotherapy uses powerful drugs that work by slowing or stopping the cancer cells from growing, spreading or multiplying to other parts of the body. Extensive studies were run all over the world during the last years to discovery some new drugs which possess anticancer effect with less toxicity and have the ability to increase the survival time. In the current study Bortezomib was employed as chemotherapeutic drug for the treatment of myeloma cells where a variable dose of Bortezomib (5, 10,20,30,50 and 100 nM/ml) were used for treatment of myeloma cells in vitro. The results obtained indicated that the T.C/ml was decreased by increasing the drug conc. compared to that of control group. These results illustrated the effect of Bortezomib on the growth of myeloma cells, where the myeloma cell division was decreased while the older cells were deteriorated so that the T.C/ml were decreased. Also the viability of myeloma cells were significantly decreased after 72 hours of addition at drug concentration 20, 30, 50 and 100 nM/ml).

An exploration of the lived experiences of individuals with relapsed multiple myeloma.

LENUS (Irish Health Repository)

Maher, K

2012-02-01

The experience of living with relapsed Multiple Myeloma (myeloma) for eight patients accessing treatment within a haematology unit in a large London hospital is explored in this study. Myeloma is recognised as incurable and is sometimes described as an \\'incurable chronic disease\\' with a main treatment option of chemotherapy. Hermeneutic phenomenology was the methodology used in conducting the study and data were collected through open-ended, unstructured interviews. Findings suggest that living with relapsed myeloma in the context of a chronic illness causes an ever-shifting perspective between illness and wellness consequently maintaining a state of uncertainty. The patients in this study placed importance on the emotional aspect of their experience. Hope, intuitive knowing and a fighting spirit were expressed as required positive elements that enabled living with relapsed myeloma. These assisted in maintaining normality, coping with bad news and adjusting to the illness. Pervading through the themes was the need to control uncertainty. Having strong support from significant others provided something to live for and the necessary social support required to promote a new orientation to life.

Multiple myeloma of the jaw: A case report

Directory of Open Access Journals (Sweden)

Shubhasini A Raghavan

2014-01-01

Full Text Available Multiple myeloma is a systemic B-cell lymphoproliferative disease that causes osteolytic lesions in the vertebra, ribs, pelvic bone, skull and jaw. Rarely jaw lesions are seen as the first sign in multiple myeloma. This is a case report with follow up of a 57-year-old female patient, previously treated for osteoporosis, who presented with a swelling of the jaw. On radiographic examination, she was found to have osteolytic lesions in the mandible and skull bones. These conventional aids led to the diagnosis of multiple myeloma thereby proving that the osteoporotic lesions were a part of the spectrum of multiple myeloma. The patient underwent chemotherapy and is currently on follow-up. This case report emphasizes the importance of early diagnosis of multiple myeloma in the jaw using readily available technologies and illustrates the contribution that oral assessment can provide.

Asymmetry in convection and restratification in the Nordic Seas: an idealized model study

Science.gov (United States)

Ypma, Stefanie L.; Brüggemann, Nils; Pietrzak, Julie D.; Katsman, Caroline A.

2017-04-01

The Nordic Seas are an important production region for dense water masses that feed the lower limb of the Atlantic Meridional Overturning Circulation. They display a pronounced hydrographic asymmetry, with a warm eastern basin, and a cold western basin. Previous studies have shown that this asymmetry is set by the interplay between large eddies shed near the coast of Norway where the continental slope steepens, and the Mohn-Knipovich ridge that separates the Lofoten Basin in the east from the Greenland Basin in the west. While it is known from earlier studies that eddies play a crucial role for the yearly cycle of wintertime convection and summertime restratification in marginal seas like the Labrador Sea, the situation in the Nordic Seas is different as the large eddies can only restratify the eastern part of the Nordic Seas due to the presence of the ridge. Possibly due to this asymmetry in eddy activity and a weaker stratification as a result, the western basin is more sensitive for intense deep convection. The question remains how this area is restratified after a deep convection event in the absence of large eddies and how the dense water is able to leave the basin. An high resolution, idealized model configuration of the MITgcm is used that reproduces the main characteristics of the Nordic Seas, including a warm cyclonic boundary current, a strong eddy field in the east and the hydrographic asymmetry between east and west. The idealized approach enables multiple sensitivity studies to changes in the eddy field and the boundary current and provides the possibility to investigate cause and effect, while keeping the set-up simple. We will present results of tracer studies where the sensitivity of the spreading and the restratification of dense water to the formation location in both basins is studied.

Nordic (cross-country) skiing injuries in Australia.

Science.gov (United States)

Sherry, E; Asquith, J

1987-03-02

A retrospective study of 88 nordic skiing injuries from the 1984 and 1985 skiing seasons in Australia is presented. To our knowledge, this is the largest study to date of such injuries. These injuries are compared with alpine skiing injuries from the same medical clinic for the 1985 skiing season. There was a much lower incidence of injury from nordic skiing; however, when injuries did occur, they tended to be more serious than those of alpine skiing and frequently required immediate evacuation to hospital for treatment. As the nordic skier is relatively isolated from medical services, these findings need to be considered in the future planning of rescue services for such skiers.

Nordic Housing Enabler

DEFF Research Database (Denmark)

Helle, Tina; Brandt, Åse

Development and reliability testing of the Nordic Housing Enabler – an instrument for accessibility assessment of the physical housing. Tina Helle & Åse Brandt University of Lund, Health Sciences, Faculty of Medicine (SE) and University College Northern Jutland, Occupational Therapy department (DK......). Danish Centre for Assistive Technology. Abstract. For decades, accessibility to the physical housing environment for people with functional limitations has been of interest politically, professionally and for the users. Guidelines and norms on accessible housing design have gradually been developed......, however, the built environment shows serious deficits when it comes to accessibility. This study addresses development of a content valid cross-Nordic version of the Housing Enabler and investigation of inter-rater reliability, when used in occupational therapy practice. The instrument was translated from...

Nordic Corporate Governance and Industrial Foundations

DEFF Research Database (Denmark)

Thomsen, Steen

to the international audience. This paper therefore reviews the Nordic corporate governance model with special emphasis on a unique ownership structure, industrial foundations (foundations that own business companies). Rather than a meticulous description of details it emphasizes the Nordic model as a mode......The Nordic countries have attracted considerable attention in recent years as a benchmark for good governance. However, while the political governance characteristics of the Nordic model – particularly the welfare state - are well understood, its corporate governance characteristics remain elusive...

Smoldering multiple myeloma risk factors for progression

DEFF Research Database (Denmark)

Sørrig, Rasmus; Klausen, Tobias W; Salomo, Morten

2016-01-01

Several risk scores for disease progression in Smoldering Multiple Myeloma (SMM) patients have been proposed, however, all have been developed using single center registries. To examine risk factors for time to progression (TTP) to Multiple Myeloma (MM) for SMM we analyzed a nationwide population......-based cohort of 321 newly diagnosed SMM patients registered within the Danish Multiple Myeloma Registry between 2005 and 2014. Significant univariable risk factors for TTP were selected for multivariable Cox regression analyses. We found that both an M-protein ≥ 30g/l and immunoparesis significantly influenced......-high risk of transformation to MM. Using only immunoparesis and M-protein ≥ 30g/l, we created a scoring system to identify low, intermediate and high risk SMM. This first population-based study of SMM patients confirms that an M-protein ≥ 30g/l and immunoparesis remain important risk factors for progression...

Performance management in the Nordic countries

DEFF Research Database (Denmark)

Kristiansen, Mads Bøge

-specific perspective, I analyze variations and similarities among countries and agencies in their development of a performance measurement system and the incorporation and use of performance information. Empirically the study shows that some patterns can be discerned but they also seem to be rather complex. Starting......This paper reports a study of performance management in practice in three tasks (Food safety, Meteorology and Prisons) across the three Scandinavian countries Denmark, Norway and Sweden. The paper examines how the system of performance management in Denmark, Norway and Sweden (Management...... from this analysis I discuss, whether it is possible to identify a Nordic model of performance management? Whether we should distinguish between an East Nordic and a West Nordic model? Should we rather talk about a Danish model, a Swedish model and a Norwegian model, or are the differences within...

Patients requests and needs for culturally and individually adapted supportive care in type 2 diabetes patients: A comparative study between Nordic and non-Nordic patients in a social economical vulnerable area of Linköping, Sweden.

Science.gov (United States)

Staff, Angelica; Garvin, Peter; Wiréhn, Ann-Britt; Yngman-Uhlin, Pia

2017-12-01

This study sought to determine and compare the metabolic control of type 2 diabetes mellitus (T2DM) in non-Nordic immigrants and native Nordics. The aim was also to describe and compare the request of supportive care between these two groups. One hundred and eighty-four patients (n=184) coming to a routine check-up in a primary healthcare setting (PHC), were consecutively enrolled to the study during a period of one year. Data on therapeutic interventions, clinical measurements, healthcare consumption, and adherence to standard diabetes healthcare program were extracted from the patientś medical record. Structured interviews on supportive care were conducted by diabetes trained nurses. If needed, a qualified interpreter was used. Comparisons were made between Nordic patients (n=151) and non-Nordic patients (n=33). Among T2DM patients in a setting of PHC, there was a difference in meeting the metabolic target HbA1c, between native Nordics and non-Nordic immigrants. There was also a difference in request on supportive care. The non-Nordic group significantly requested more and different supportive care. They also attended the standard diabetes program to a lesser degree. Culturally/individually adapted prevention is not only medically warranted but also requested by the patients themselves. Copyright © 2017 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

Clinical Application of 18F-FDG PET in Multiple Myeloma

International Nuclear Information System (INIS)

Lee, Su Jin; Choi, Joon Young

2009-01-01

This review focuses on the clinical use of 18 F-FDG PET to evaluate multiple myeloma. 18 F-FDG PET is useful for diagnosis, staging of multiple myeloma and differential diagnosis of myeloma related disease such as monoclonal gammopathy of undetermined significance or plasmacytoma. For therapy response, 18 F-FDG PET may be effective after chemotherapy for multiple myeloma and radiotherapy for plasmacytoma

Developing Nordic Pedagogical Best Practice

DEFF Research Database (Denmark)

Bagger, Bettan; Kelly, Hélène; Wonsyld, Merete

2012-01-01

This article describes a Nordic educational project that supported dialogue and cooperation between nursing students and educators from eight Nordic educational institutions. An intensive course concept was developed. The course focus of prevention and health promotion among nordic youth not only...... illuminated the benefits of student exchange with respect to student learning but also how pedagogical cooperation can contribute to institutional, pedagogical innovation. Keywords Cooperation, pedagogcial development, comparative nursing, pedagogical best practice....

Myeloma: making sense of a complex blood cancer.

LENUS (Irish Health Repository)

Kelly, Mary B

2012-01-31

Myeloma is a challenging blood cancer characterized by bone destruction, hypercalcaemia, renal insufficiency and anaemia. Although myeloma remains incurable, recent advancements in treatments have resulted in significant improvements in morbidity. The use of immunomodulatory drugs-thalidomide, lenalidomide, pomalidomide (in clinical trials)-and the proteasome inhibitor, bortezomib, in conjunction with conventional chemotherapy and supportive therapies, have resulted in a significant shift in approaches to treatment and an improvement in patients\\' quality of life. Nurses must remain up-to-date with current treatments for myeloma and their related side-effects. In addition, nurses play a key role in the coordination of a multidisciplinary approach to care for myeloma patients.

Hypercoagulable states in patients with multiple myeloma can affect the thalidomide-associated venous thromboembolism.

Science.gov (United States)

Talamo, Giampaolo P; Ibrahim, Sulfi; Claxton, David; Tricot, Guido J; Fink, Louis M; Zangari, Maurizio

2009-07-01

The therapeutic use of thalidomide in patients with multiple myeloma is often complicated by the development of venous thromboembolism. The objective of the present study was to identify hypercoagulable states associated with development of venous thromboembolism in thalidomide-treated multiple myeloma patients. We screened 49 consecutive multiple myeloma patients treated with thalidomide at baseline for hypercoagulability. With a median follow-up of 11 months, 10 of 49 multiple myeloma patients developed a thrombotic episode. Laboratory assays revealed an underlying abnormality in nine of the 10 patients; hypercoagulable screenings were normal in 36 of the 39 patients who did not develop venous thromboembolism (P < 0.0001). Our retrospective study results suggest that the multiple myeloma patients with thromboembolic complications during treatment with thalidomide have a frequent concomitant underlying thrombophilic state.

Nordic Analysis of Climate Friendly Buildings

DEFF Research Database (Denmark)

Andresen, Inger; Thomsen, Kirsten Engelund; Wahlstrøm, Åsa

This report summarizes the findings of the work conducted within the project “Nordic Analysis of Climate Friendly Buildings”, financed by the Nordic Council of Ministers. The main goal of the project was to establish a knowledge and decision base for a Nordic innovation program that will promote...... the development and demonstration of low energy and climate friendly buildings. The innovation program should support a development that brings the Nordic countries to an international forefront with respect to business strongholds and market penetration of low energy and climate friendly buildings....

Nordic Walking as an Exercise Intervention to Reduce Pain in Women With Aromatase Inhibitor-Associated Arthralgia: A Feasibility Study.

Science.gov (United States)

Fields, Jo; Richardson, Alison; Hopkinson, Jane; Fenlon, Deborah

2016-10-01

Women taking aromatase inhibitors as treatment for breast cancer commonly experience joint pain and stiffness (aromatase inhibitor-associated arthralgia [AIAA]), which can cause problems with adherence. There is evidence that exercise might be helpful, and Nordic walking could reduce joint pain compared to normal walking. To determine the feasibility of a trial of Nordic walking as an exercise intervention for women with AIAA. A feasibility study was carried out in a sample of women with AIAA using a randomized control design. Women were randomized to exercise (six-week supervised group Nordic walking training once per week with an increasing independent element, followed by six weeks 4 × 30 minutes/week independent Nordic walking); or enhanced usual care. Data were collected on recruitment, retention, exercise adherence, safety, and acceptability. The Brief Pain Inventory, GP Physical Activity Questionnaire, and biopsychosocial measures were completed at baseline, six and 12 weeks. Forty of 159 eligible women were recruited and attrition was 10%. There was no increased lymphedema and no long-term or serious injury. Adherence was >90% for weekly supervised group Nordic walking, and during independent Nordic walking, >80% women managed one to two Nordic walking sessions per week. From baseline to study end point, overall activity levels increased and pain reduced in both the intervention and control groups. Our findings indicate that women with AIAA are prepared to take up Nordic walking, complete a six-week supervised course and maintain increased activity levels over a 12-week period with no adverse effects. Copyright © 2016 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

Study of Demand as Frequency Controlled Reserve in Nordic Power System

DEFF Research Database (Denmark)

Zhao, Haoran; Wu, Qiuwei; Huang, Shaojun

2016-01-01

This paper investigates the efficacy of Demand Frequency Reserve (DFR) in Nordic power system. Heat pump, due to its switching flexibility, less disturbing impacts to customers and promising future in application, is used to represent DFR in the study. Thermodynamics of the heat pump unit...

Action plan for Nordic energy co-operation 2006-2009

International Nuclear Information System (INIS)

2005-01-01

The Action Plan for Nordic Energy Co-operation 2006-2009 is targeted at creating a visible and sustainable contribution to solving the most important and politically most relevant energy policy challenges faced by the Nordic region. The plan concentrates on three main areas: Energy markets; Sustainable energy system; and Nordic impact on the international agenda. The Action Plan is the energy sector's contribution to the implementation of the Nordic strategy 'Sustainable Development - New Bearing for the Nordic Countries' and to a number of the Nordic Council's recommendations for the development of the Nordic energy sector. An important element of the implementation of the action plan is on-going contact and information sharing between the Nordic Energy Policy co-operation and the Nordic Energy Research. The continues dialogue between the Nordic Council of Energy Ministers and The Nordic Council on future energy policy challenges will likewise be an important part of the political process. (BA)

Simple or Complex Stenting for Bifurcation Coronary Lesions: A Patient-Level Pooled-Analysis of the Nordic Bifurcation Study and the British Bifurcation Coronary Study

DEFF Research Database (Denmark)

Behan, Miles W; Holm, Niels Ramsing; Curzen, Nicholas P

2011-01-01

Background— Controversy persists regarding the correct strategy for bifurcation lesions. Therefore, we combined the patient-level data from 2 large trials with similar methodology: the NORDIC Bifurcation Study (NORDIC I) and the British Bifurcation Coronary Study (BBC ONE). Methods and Results— B...

School meal provision, health, and cognitive function in a Nordic setting - the ProMeal-study: description of methodology and the Nordic context.

Science.gov (United States)

Waling, Maria; Olafsdottir, Anna S; Lagström, Hanna; Wergedahl, Hege; Jonsson, Bert; Olsson, Cecilia; Fossgard, Eldbjørg; Holthe, Asle; Talvia, Sanna; Gunnarsdottir, Ingibjorg; Hörnell, Agneta

2016-01-01

School meals, if both nutritious and attractive, provide a unique opportunity to improve health equality and public health. To describe the study rationale, data collection, and background of participants in the study 'Prospects for promoting health and performance by school meals in Nordic countries' (ProMeal). The general aim was to determine whether overall healthiness of the diet and learning conditions in children can be improved by school lunches, and to capture the main concerns regarding school lunches among children in a Nordic context. A cross-sectional, multidisciplinary study was performed in Finland, Iceland, Norway, and Sweden on pupils (n=837) born in 2003. In total 3,928 pictures of school lunches were taken to capture pupils' school lunch intake. A mean of 85% of all parents responded to a questionnaire about socioeconomic background, dietary intake, and habitual physical activity at home. Cognitive function was measured on one occasion on 93% of the pupils during optimal conditions with a Stroop and a Child Operation Span test. A mean of 169 pupils also did an Integrated Visual and Auditory Continuous Performance Test after lunch over 3 days. In total, 37,413 10-sec observations of classroom learning behavior were performed. In addition, 753 empathy-based stories were written and 78 focus groups were conducted. The pupils had high socioeconomic status. This study will give new insights into which future interventions are needed to improve pupils' school lunch intake and learning. The study will provide valuable information for policy making, not least in countries where the history of school meals is shorter than in some of the Nordic countries.

Psoriatic arthritis mutilans (PAM) in the Nordic countries: demographics and disease status. The Nordic PAM study.

Science.gov (United States)

Gudbjornsson, B; Ejstrup, L; Gran, J T; Iversen, L; Lindqvist, U; Paimela, L; Ternowitz, T; Ståhle, M

2013-01-01

To determine the prevalence and clinical characteristics of psoriatic arthritis mutilans (PAM) in the Nordic countries. Patients with putative PAM aged ≥ 18 years were recruited. Fifty-nine patients were included after clinical examination. The prevalence of PAM in the adult Nordic population was estimated to be 3.69 per million inhabitants [95% confidence interval (CI) 2.75-4.63]. The female to male ratio was close to 1:1. The mean age of skin disease onset was 25 years and the mean age of onset of joint disease was 30 years. The onset of skin disease was 2 years earlier among female patients. At inclusion, the mean duration of arthritis was 27 ± 11 years for male patients and 33 ± 11 years for female patients. PAM was most frequently seen in the distal interphalangeal (DIP) joints of the toes, followed by the IP joint of the thumb and the DIP joint of the little finger on the left hand. Female and male patients had similar numbers of painful and swollen joints. Enthesitis was found in 19 patients (32%), while 38 patients (64%) had a history of dactylitis. Twenty-three of these 38 patients (61%) had a history of dactylitis in the same finger/toe as they had PAM. At the time of inclusion, 45% of the patients were found to have clear or almost clear skin. PAM in the Nordic countries has a low prevalence, with only three to five cases per million inhabitants. The majority of the patients present with mild skin disease.

Technology foresight in the Nordic countries

DEFF Research Database (Denmark)

Eerola, A.; Jørgensen, Birte Holst

2002-01-01

and the society at large at the sametime. The report recommends: 1. The establishment of a Nordic forum for technology foresight practitioners and researchers. 2. The creation of a common follow-up system for relevant international technology foresight exercises. 3. The realisation oftechnology foresight......Technology foresight (TF) is increasingly used by governments, funding agencies, R&D institutions and private companies as a tool for strategy development, prioritisation of R&D funds, and learning. Although the Nordic Council of Ministers aims at"developing Nordic region in next 10 years...... and social differences among the Nordic countries. Nordic foresight cooperation may alsoremain as a distant academic exercise if proper links to political and economic decisions cannot be made and maintained. A technology foresight exercise might serve different institutions of the innovation system...

Sexual dysfunction in multiple myeloma: survivorship care plan of the International Myeloma Foundation Nurse Leadership Board.

Science.gov (United States)

Richards, Tiffany A; Bertolotti, Page A; Doss, Deborah; McCullagh, Emily J

2011-08-01

The World Health Organization describes sexuality as a "central aspect of being human throughout life and encompasses sex, gender identities and roles, sexual orientation, eroticism, pleasure, intimacy, and reproduction. Sexuality is influenced by the interaction of biological, psychological, social, economic, political, cultural, ethical, legal, historical, religious, and spiritual factors." Currently, no research has been conducted regarding sexual dysfunction in patients with multiple myeloma; therefore, information related to the assessment and evaluation of sexual dysfunction is gleaned from other malignancies and diseases. In this article, members of the International Myeloma Foundation's Nurse Leadership Board discuss the definition, presentation, and causes of sexual dysfunction; provide recommendations for sexual assessment practices; and promote discussion among patients with multiple myeloma, their healthcare providers, and their partners.

Absenteeism in the Nordic countries

DEFF Research Database (Denmark)

Løkke Nielsen, Ann-Kristina; Eskildsen, Jacob Kjær; Jensen, Troels Wendelboe

2007-01-01

and Sweden. Employees working in the public sector, more specific the municipalities, have a higher level of absence compared to the private sector. According to the personal characteristics, women are more absent than men in all Nordic countries, but the effect of age differs according to the country...... in question. If the manager however is a woman and the employee likewise, then the level of absence is higher in Denmark, Norway and Finland compared to the other gender constellations. Originality/value - Because of the lack of international comparative studies of absenteeism in the Nordic countries...

The Danish National Multiple Myeloma Registry

DEFF Research Database (Denmark)

Gimsing, Peter; Holmström, Morten Orebo; Klausen, Tobias Wirenfelt

2016-01-01

AIM: The Danish National Multiple Myeloma Registry (DMMR) is a population-based clinical quality database established in January 2005. The primary aim of the database is to ensure that diagnosis and treatment of plasma cell dyscrasia are of uniform quality throughout the country. Another aim...... diagnosed patients with multiple myeloma (MM), smoldering MM, solitary plasmacytomas, and plasma cell leukemia in Denmark are registered annually; ~350 patients. Amyloid light-chain amyloidosis, POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome......), monoclonal gammopathy of undetermined significance and monoclonal gammopathy of undetermined significance with polyneuropathy have been registered since 2014. MAIN VARIABLES: The main registered variables at diagnosis are patient demographics, baseline disease characteristics, myeloma-defining events...

Immunoparesis in newly diagnosed Multiple Myeloma patients

DEFF Research Database (Denmark)

Sorrig, Rasmus; Klausen, Tobias W.; Salomo, Morten

2017-01-01

Immunoparesis (hypogammaglobulinemia) is associated to an unfavorable prognosis in newly diagnosed Multiple myeloma (MM) patients. However, this finding has not been validated in an unselected population-based cohort. We analyzed 2558 newly diagnosed MM patients in the Danish Multiple Myeloma...

Innovating and re-branding Nordic wellbeing tourism

DEFF Research Database (Denmark)

Hjalager, Anne-Mette; Konu, H.; Huijbens., E.H.

2011-01-01

Driving forces behind the successful development of coherent wellbeing tourism in the Nordic region. An innovation perspective on developing a particular Nordic content of wellbeing offered by tourism enterprises and destinations across the five Nordic countries...

A Nordic perspective on career competences and guidance

DEFF Research Database (Denmark)

Thomsen, Rie

This concept note reflects an initiative within the Nordic ELPGN group, in partnership with the Nordic network for adult learning (NVL), to investigate the possibilities for collaboration between the Nordic countries in developing a number of joint documents on career competences and....../or a competence framework for career learning in the Nordic countries. The objective for this concept note is to contribute to a shared Nordic frame of understanding for career competences which can be used in the ongoing development of guidance in the Nordic countries. The intended audience is guidance...... professionals, teachers, researchers, managers, policy makers and clients....

Current research in transcultural psychiatry in the Nordic countries.

Science.gov (United States)

Ekblad, Solvig; Kastrup, Marianne Carisius

2013-12-01

This article discusses major themes in recent transcultural psychiatric research in the Nordic countries from 2008 to 2011: (a) epidemiological studies of migration, (b) indigenous populations, and (c) quality of psychiatric care for migrants. Over the past several decades, the populations of the Nordic countries, Denmark, Finland, Norway, and Sweden, which were relatively homogeneous, have become increasingly culturally diverse. Many migrants to Nordic countries have been exposed to extreme stress, such as threats of death and/or torture and other severe social adversities before, during, and after migration, with potential effects on their physical, mental, social, and spiritual health. Growing interest in transcultural issues is reflected in the level of scientific research and clinical activity in the field by Nordic physicians, psychologists, social scientists, demographers, medical anthropologists, as well as other clinicians and policy planners. Research includes work with migrants and indigenous minorities in the Nordic countries, as well as comparisons with mental health in postconflict countries. We conclude by suggesting future directions for transcultural psychiatry research and providing guidelines for the education and training of future clinicians in the Nordic countries.

An empirical study of real estate stock return behavior on the Nordic markets : – A 2003-2013 study

OpenAIRE

Mäki, David; Lundström, Martin

2013-01-01

The financial crisis has made the stock markets a very turbulent place. Investors have therefore begun searching for stable and profitable investments. Nordic real estate has for decades steadily increased in value and the stocks of real estate companies are said to be less risky than the market. This has led to a view of them being a safe haven for risk adverse investors. Very few empirical studies have been done on how these supposedly safe stocks actually behave in the Nordic countries. Th...

Hamstring Muscle Use in Females During Hip-Extension and the Nordic Hamstring Exercise: An fMRI Study.

Science.gov (United States)

Messer, Daniel J; Bourne, Matthew N; Williams, Morgan D; Al Najjar, Aiman; Shield, Anthony J

2018-04-23

Study Design Cross-sectional study. Background Understanding hamstring muscle activation patterns in resistance training exercises may have implications for the design of strength training and injury prevention programs. Unfortunately, surface electromyography studies have reported conflicting results with regard to hamstring muscle activation patterns in women. Objectives To determine the spatial patterns of hamstring muscle activity during the 45º hip-extension and Nordic hamstring exercises, in females using functional magnetic resonance imaging. Methods Six recreationally active females with no history of lower limb injury underwent functional magnetic resonance imaging (fMRI) on both thighs before and immediately after 5 sets of 6 bilateral eccentric contractions of the 45º hip-extension or Nordic exercises. Using fMRI, the transverse (T2) relaxation times were measured from pre- and post- exercise scans and the percentage increase in T2 was used as an index of muscle activation. Results fMRI revealed a significantly higher biceps femoris long head (BF LongHead ) to semitendinosus ratio during the 45° hip-extension than the Nordic exercise (P = .028). The T2 increase after 45° hip-extension was greater for BF LongHead (P Nordic exercise, the T2 increase for semitendinosus was greater than that of BF ShortHead (P Nordic exercise preferentially recruits that muscle while the hip extension more evenly activates all of the biarticular hamstrings. J Orthop Sports Phys Ther, Epub 23 Apr 2018. doi:10.2519/jospt.2018.7748.

Report from the European Myeloma Network on interphase FISH in multiple myeloma and related disorders

DEFF Research Database (Denmark)

Ross, Fiona M; Avet-Loiseau, Hervé; Ameye, Geneviève

2012-01-01

The European Myeloma Network has organized two workshops on fluorescence in situ hybridization in multiple myeloma. The first aimed to identify specific indications and consensus technical approaches of current practice. A second workshop followed a quality control exercise in which 21 laboratories...... analyzed diagnostic cases of purified plasma cells for recurrent abnormalities. The summary report was discussed at the EHA Myeloma Scientific Working Group Meeting 2010. During the quality control exercise, there was acceptable agreement on more than 1,000 tests. The conclusions from the exercise were...... that the primary clinical applications for FISH analysis were for newly diagnosed cases of MM or frank relapse cases. A range of technical recommendations included: 1) material should be part of the first draw of the aspirate; 2) samples should be sent at suitable times to allow for the lengthy processing...

Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase

OpenAIRE

Brown, Charles O.; Salem, Kelley; Wagner, Brett A.; Bera, Soumen; Singh, Neeraj; Tiwari, Ajit; Choudhury, Amit; Buettner, Garry R.; Goel, Apollina

2012-01-01

IL (interleukin)-6, an established growth factor for multiple myeloma cells, induces myeloma therapy resistance, but the resistance mechanisms remain unclear. The present study determines the role of IL-6 in re-establishing intracellular redox homoeostasis in the context of myeloma therapy. IL-6 treatment increased myeloma cell resistance to agents that induce oxidative stress, including IR (ionizing radiation) and Dex (dexamethasone). Relative to IR alone, myeloma cells treated with IL-6 plu...

Differences in medical services in Nordic general practice: a comparative survey from the QUALICOPC study.

Science.gov (United States)

Eide, Torunn Bjerve; Straand, Jørund; Björkelund, Cecilia; Kosunen, Elise; Thorgeirsson, Ofeigur; Vedsted, Peter; Rosvold, Elin Olaug

2017-06-01

We aim to describe medical services provided by Nordic general practitioners (GPs), and to explore possible differences between the countries. We did a comparative analysis of selected data from the Nordic part of the study Quality and Costs of Primary Care in Europe (QUALICOPC). A total of 875 Nordic GPs (198 Norwegian, 80 Icelandic, 97 Swedish, 212 Danish and 288 Finnish) answered identical questionnaires regarding their practices. The GPs indicated which equipment they used in practice, which procedures that were carried out, and to what extent they were involved in treatment/follow-up of a selection of diagnoses. The Danish GPs performed minor surgical procedures significantly less frequent than GPs in all other countries, although they inserted IUDs significantly more often than GPs in Iceland, Sweden and Finland. Finnish GPs performed a majority of the medical procedures more frequently than GPs in the other countries. The GPs in Iceland reported involvement in a more narrow selection of conditions than the GPs in the other countries. The Finnish GPs had more advanced technical equipment than GPs in all other Nordic countries. GPs in all Nordic countries are well equipped and offer a wide range of medical services, yet with a substantial variation between countries. There was no clear pattern of GPs in one country doing consistently more procedures, having consistently more equipment and treating a larger diversity of medical conditions than GPs in the other countries. However, structural factors seemed to affect the services offered.

Control mechanisms for Nordic ship emissions

Energy Technology Data Exchange (ETDEWEB)

Martinsen, K. [DNV, Oslo (Norway); Torvanger, A. [Cicero, Oslo (Norway)

2013-04-15

Shipping today operates under a complex set of international and domestic regulations. However, the environmental regulations have lagged behind those of other industries. This situation is now changing quite dramatically. The increased focus on environmental issues, combined with the growing realisation of the actual pollution burden imposed by shipping, has led to an upsurge in both international and national regulations. Some are ready and will enter into force in the near future, while others are still being developed. On behalf of the Nordic Council of Ministers DNV has carried out a study on possible control mechanisms for Nordic ship emission. The aim is to assess the baseline shipping emissions and reduction potential and the possible controlling mechanisms (both incentives and regulations) available for reducing the emissions to air from shipping within the Nordic region. (Author)

Hypothalamic digoxin, hemispheric chemical dominance, and oncogenesis: evidence from multiple myeloma.

Science.gov (United States)

Kurup, Ravi Kumar; Kurup, Paramesware Achutha

2003-12-01

This study assessed the changes in the isoprenoid pathway and its metabolites digoxin, dolichol, and ubiquinone in multiple myeloma. The isoprenoid pathway and digoxin status were also studied for comparison in individuals of differing hemispheric dominance to find out the rote of cerebral dominance in the genesis of multiple myeloma and neoplasms. The following parameters were assessed: isoprenoid pathway metabolites, tyrosine and tryptophan catabolites, glycoconjugate metabolism, RBC membrane composition, and free radical metabolism--in multiple myeloma, as well as in individuals of differing hemispheric dominance. There was elevation in plasma HMG CoA reductase activity, serum digoxin, and dolichol, and a reduction in RBC membrane Na(+)-K+ ATPase activity, serum ubiquinone, and magnesium levels. Serum tryptophan, serotonin, nicotine, strychnine, and quinolinic acid were elevated, while tyrosine, dopamine, noradrenaline, and morphine were decreased. The total serum glycosaminoglycans and glycosaminoglycan fractions, the activity of GAG degrading enzymes and glycohydrolases, carbohydrate residues of glycoproteins, and serum glycolipids were elevated. The RBC membrane glycosaminoglycans, hexose, and fucose residues of glycoproteins, cholesterol, and phospholipids were reduced. The activity of all free-radical scavenging enzymes, concentration of glutathione, iron binding capacity, and ceruloplasmin decreased significantly, while the concentration of lipid peroxidation products and nitric oxide increased. Hyperdigoxinemia-related altered intracellular Ca++/Mg++ ratios mediated oncogene activation, dolichol-induced altered glycoconjugate metabolism, and ubiquinone deficiency-related mitochondrial dysfunction can contribute to the pathogenesis of multiple myeloma. The biochemical patterns obtained in multiple myeloma are similar to those obtained in left-handed/right hemispheric chemically dominant individuals by the dichotic listening test. But all the patients with

Immune resistance of Multiple Myeloma : the role of the microenvironment

NARCIS (Netherlands)

de Haart, SJ

2017-01-01

Immunotherapeutic strategies in Multiple Myeloma are under development. In this thesis we present a new perspective in optimizing immunotherapy in Multiple Myeloma patient. We propose that currently, immunotherapy is limited in efficacy through interactions of Multiple Myeloma cells with the bone

Market design : Common Nordic end-user market

Energy Technology Data Exchange (ETDEWEB)

2009-07-01

No later than 2015, suppliers in the Nordic countries should be able to offer electricity to consumers in any Nordic country on equal terms. In this report NordREG has analyzed the present situation in the Nordic countries and identified the issues that should be harmonised in order to establish a common Nordic end-user market. In this report NordREG also suggests an indicative road map for the implementation process. (Author)

CONFERENCE: Nordic physics

International Nuclear Information System (INIS)

Anon.

1984-01-01

Around 80 physicists from eleven countries fought heavy snowstorms and 20-below temperatures at the winter resort of Spåtind, Norway, for the 8th Nordic Meeting on Elementary Particle Physics in January. This biennial conference is a traditional meeting place for Nordic particle physicists, and especially for the young research students, but also draws participants from other countries. This year's meeting was organized by the Division of Particle Physics of the Swedish Physical Society

Coffee and Green Tea Consumption and Subsequent Risk of Malignant Lymphoma and Multiple Myeloma in Japan: The Japan Public Health Center-based Prospective Study.

Science.gov (United States)

Ugai, Tomotaka; Matsuo, Keitaro; Sawada, Norie; Iwasaki, Motoki; Yamaji, Taiki; Shimazu, Taichi; Sasazuki, Shizuka; Inoue, Manami; Kanda, Yoshinobu; Tsugane, Shoichiro

2017-08-01

Background: The aim of this study was to investigate the association of coffee and green tea consumption and the risk of malignant lymphoma and multiple myeloma in a large-scale population-based cohort study in Japan. Methods: In this analysis, a total of 95,807 Japanese subjects (45,937 men and 49,870 women; ages 40-69 years at baseline) of the Japan Public Health Center-based Prospective Study who completed a questionnaire about their coffee and green tea consumption were followed up until December 31, 2012, for an average of 18 years. HRs and 95% confidence intervals were estimated using a Cox regression model adjusted for potential confounders as a measure of association between the risk of malignant lymphoma and multiple myeloma associated with coffee and green tea consumption at baseline. Results: During the follow-up period, a total of 411 malignant lymphoma cases and 138 multiple myeloma cases were identified. Overall, our findings showed no significant association between coffee or green tea consumption and the risk of malignant lymphoma or multiple myeloma for both sexes. Conclusions: In this study, we observed no significant association between coffee or green tea consumption and the risk of malignant lymphoma or multiple myeloma. Impact: Our results do not support an association between coffee or green tea consumption and the risk of malignant lymphoma or multiple myeloma. Cancer Epidemiol Biomarkers Prev; 26(8); 1352-6. ©2017 AACR . ©2017 American Association for Cancer Research.

Nordic Walking Practice Might Improve Plantar Pressure Distribution

Science.gov (United States)

Perez-Soriano, Pedro; Llana-Belloch, Salvador; Martinez-Nova, Alfonso; Morey-Klapsing, G.; Encarnacion-Martinez, Alberto

2011-01-01

Nordic walking (NW), characterized by the use of two walking poles, is becoming increasingly popular (Morgulec-Adamowicz, Marszalek, & Jagustyn, 2011). We studied walking pressure patterns of 20 experienced and 30 beginner Nordic walkers. Plantar pressures from nine foot zones were measured during trials performed at two walking speeds (preferred…

Fundamentals in the management of multiple myeloma.

Science.gov (United States)

Fadilah, S A W

2010-09-01

Progress in our understanding of multiple myeloma and its treatment has resulted in a more tailored approach to patient management, with different therapeutics regimens for different patient populations. The decision to initiate therapy depends primarily on the presence of symptoms which has to balance the chance of tumor clearance and against the risks of treatment related mortality. Selection of appropriate initial treatment should be based primarily on patient's characteristics (biologic age, co-morbidities), the disease characteristics (tumor burden and genetic risk profile) and the expected toxicity profile of the different regimens. When treatment begins, in younger transplant eligible patients the goal is to achieve high quality responses with intensive therapies as the quality of response appears to be important surrogates for long-term outcome. In the majority of myeloma patients in whom intensive treatment is not an option due to advanced age and co-morbidities, treatment should emphasize on optimal disease control to obtain symptomatic relief and to maintain a satisfactory quality of life. The introduction of novel agents has substantially changed the treatment paradigm of this otherwise incurable disease. The utilization of these drugs has moved from relapse setting to the front line setting and has benefited all patient groups. Because of these rapid developments and many treatment options we need good quality clinical studies to guide clinical practice in the management of patients with multiple myeloma. This review presents an update on current concepts of diagnosis and treatment of patients with multiple myeloma and provides recommendations on tailored therapies with particular reference to the local practice. The information presented herein may be used by the health care providers caring for myeloma patients as a guideline to counsel patients to understand their disease and the treatment better.

E-learning Nordic 2006

DEFF Research Database (Denmark)

Pedersen, Sanya Gertsen

2006-01-01

E-learning Nordic 2006 er den første fællesnordiske undersøgelse, som specifikt fokuserer på effekten af it i uddannelsessektoren. Studiet er gennemført i Finland, Sverige, Norge og Danmark og mere end 8000 personer (elever, lærere, forældre og skoleledere i grundskoler og på de gymnasiale...... ungdomsuddannelser) har deltaget. Dette studie giver en række svar på centrale spørgsmål såsom: Hvad har vi fået ud af satsningen på it i uddannelsessektoren indtil nu? Og hvilke udfordringer inden for uddannelsessektoren står de nordiske lande foran i en globaliseret verden? E-learning Nordic 2006 er designet og...

Global myeloma research clusters, output, and citations: a bibliometric mapping and clustering analysis.

Directory of Open Access Journals (Sweden)

Jens Peter Andersen

Full Text Available International collaborative research is a mechanism for improving the development of disease-specific therapies and for improving health at the population level. However, limited data are available to assess the trends in research output related to orphan diseases.We used bibliometric mapping and clustering methods to illustrate the level of fragmentation in myeloma research and the development of collaborative efforts. Publication data from Thomson Reuters Web of Science were retrieved for 2005-2009 and followed until 2013. We created a database of multiple myeloma publications, and we analysed impact and co-authorship density to identify scientific collaborations, developments, and international key players over time. The global annual publication volume for studies on multiple myeloma increased from 1,144 in 2005 to 1,628 in 2009, which represents a 43% increase. This increase is high compared to the 24% and 14% increases observed for lymphoma and leukaemia. The major proportion (>90% of publications was from the US and EU over the study period. The output and impact in terms of citations, identified several successful groups with a large number of intra-cluster collaborations in the US and EU. The US-based myeloma clusters clearly stand out as the most productive and highly cited, and the European Myeloma Network members exhibited a doubling of collaborative publications from 2005 to 2009, still increasing up to 2013.Multiple myeloma research output has increased substantially in the past decade. The fragmented European myeloma research activities based on national or regional groups are progressing, but they require a broad range of targeted research investments to improve multiple myeloma health care.

The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment for multiple myeloma.

Science.gov (United States)

Evans, Robert P; Naber, Claudia; Steffler, Tara; Checkland, Tamara; Maxwell, Christopher A; Keats, Jonathan J; Belch, Andrew R; Pilarski, Linda M; Lai, Raymond; Reiman, Tony

2008-02-01

Aurora kinases are potential targets for cancer therapy. Previous studies have validated Aurora kinase A as a therapeutic target in multiple myeloma (MM), and have demonstrated in vitro anti-myeloma effects of small molecule Aurora kinase inhibitors that inhibit both Aurora A and B. This study demonstrated that Aurora B kinase was strongly expressed in myeloma cell lines and primary plasma cells. The selective Aurora B inhibitor AZD1152-induced apoptotic death in myeloma cell lines at nanomolar concentrations, with a cell cycle phenotype consistent with that reported previously for Aurora B inhibition. In some cases, AZD1152 in combination with dexamethasone showed increased anti-myeloma activity compared with the use of either agent alone. AZD1152 was active against sorted CD138(+) BM plasma cells from myeloma patients but also, as expected, was toxic to CD138(-) marrow cells from the same patients. In a murine myeloma xenograft model, AZD1152-inhibited tumour growth at well-tolerated doses and induced cell death in established tumours, with associated mild, transient leucopenia. AZD1152 shows promise in these preclinical studies as a novel treatment for MM.

The Nordic Health Promotion Research Network (NHPRN).

Science.gov (United States)

Ringsberg, Karin C

2015-08-01

The Nordic Health Promotion Research Network (NHPRN) was established in 2007 at the Nordic School of Public Health (NHV). This article aims to describe the foundation of the NHPRN, the development and the present status of the work of NHPRN. The NHPRN consists of about 50 senior and junior researchers from all Nordic countries. It is a working network that aims to develop the theoretical understanding of health promotion, to create research cooperation in health promotion from a Nordic perspective and to extend the scope of health promotion through education. Network members meet biannually to discuss and further develop research within the field and are also responsible for the Nordic conference on Health Promotion, organized every 3 years. The NHV hosted the network between 2007 and 2014; and the World Health Organisation (WHO) will assume this role in 2015. © 2015 the Nordic Societies of Public Health.

Partnerships in Nordic Building Industry

DEFF Research Database (Denmark)

The project had two main objectives. The first was to establish a Nordic network of people and organisations interested in partnerships and partnering in the building industry in order to facilitate the exchange of experiences and new ideas. This objective was met through a series of workshops......, the functioning of specific partnering tools, knowledge management, training etc. Whereas the growth of partnering in all of the Nordic construction industries has developed from inspiration from the UK, and from other Nordic countries, it is the overall impression that partnering is interpreted, implemented...

The Nordic EIA-effectiveness workshop. A contribution to the international study of effectiveness of environmental assessment

Energy Technology Data Exchange (ETDEWEB)

Hilden, M.; Laitinen, R. [eds.

1995-09-01

The Nordic EIA-effectiveness (Environmental Impact Assessment) workshop met in Tuusula, Finland 10-12 april 1994. EIA-experts from all Nordic countries and Canada discussed cases in which environmental impact assessment procedures had been applied with varying success. Nordic cases are included in the proceedings as separate chapters. The problems and successes of diverse cases allowed experts to identify key issues and avenues for future development. The reports of the working groups cover all stages of the EIA-process and provide reference material for future studies. `How can we ensure that EIA, which now has legal backing in all Nordic countries, becomes an efficient way to improve public participation and to avoid deleterious changes in the environment?` is the basic theme. Several recommendations were put forward for building on the results of the workshop, i.e. to: 1) elaborate and consolidate the criteria developed by the working groups and cross reference with the results of other international workshops; 2) review their application of EIA capacity building in countries with transitional economies; 3) test the proposed guidelines of good practice in EIAs in Nordic countries and disseminate the results; establish ecosystem specific approaches for sensitive and distinctive bioregions; and 5) focus on the Arctic as a priority area shared by eight northern countries and covered by a regional environmental strategy. (AB)

Plasma cell morphology in multiple myeloma and related disorders.

Science.gov (United States)

Ribourtout, B; Zandecki, M

2015-06-01

Normal and reactive plasma cells (PC) are easy to ascertain on human bone marrow films, due to their small mature-appearing nucleus and large cytoplasm, the latter usually deep blue after Giemsa staining. Cytoplasm is filled with long strands of rough endoplasmic reticulum and one large Golgi apparatus (paranuclear hof), demonstrating that PC are dedicated mainly to protein synthesis and excretion (immunoglobulin). Deregulation of the genome may induce clonal expansion of one PC that will lead to immunoglobulin overproduction and eventually to one among the so-called PC neoplasms. In multiple myeloma (MM), the number of PC is over 10% in most patients studied. Changes in the morphology of myeloma PC may be inconspicuous as compared to normal PC (30-50% patients). In other instances PC show one or several morphological changes. One is related to low amount of cytoplasm, defining lymphoplasmacytoid myeloma (10-15% patients). In other cases (40-50% patients), named immature myeloma cases, nuclear-cytoplasmic asynchrony is observed: presence of one nucleolus, finely dispersed chromatin and/or irregular nuclear contour contrast with a still large and blue (mature) cytoplasm. A peculiar morphological change, corresponding to the presence of very immature PC named plasmablasts, is observed in 10-15% cases. Several prognostic morphological classifications have been published, as mature myeloma is related to favorable outcome and immature myeloma, peculiarly plasmablastic myeloma, is related to dismal prognosis. However, such classifications are no longer included in current prognostic schemes. Changes related to the nucleus are very rare in monoclonal gammopathy of unknown significance (MGUS). In contrast, anomalies related to the cytoplasm of PC, including color (flaming cells), round inclusions (Mott cells, Russell bodies), Auer rod-like or crystalline inclusions, are reported in myeloma cases as well as in MGUS and at times in reactive disorders. They do not correspond

The Nordic Approach to the Experience Economy

DEFF Research Database (Denmark)

Bille, Trine

This paper discusses the concept of the experience economy in a Nordic context and shows how the Nordic version of the concept has come about from a mix of three different approaches and theories. Besides, the Nordic definition links the experience economy closely with cultural activities...

Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase.

Science.gov (United States)

Brown, Charles O; Salem, Kelley; Wagner, Brett A; Bera, Soumen; Singh, Neeraj; Tiwari, Ajit; Choudhury, Amit; Buettner, Garry R; Goel, Apollina

2012-06-15

IL (interleukin)-6, an established growth factor for multiple myeloma cells, induces myeloma therapy resistance, but the resistance mechanisms remain unclear. The present study determines the role of IL-6 in re-establishing intracellular redox homoeostasis in the context of myeloma therapy. IL-6 treatment increased myeloma cell resistance to agents that induce oxidative stress, including IR (ionizing radiation) and Dex (dexamethasone). Relative to IR alone, myeloma cells treated with IL-6 plus IR demonstrated reduced annexin/propidium iodide staining, caspase 3 activation, PARP [poly(ADP-ribose) polymerase] cleavage and mitochondrial membrane depolarization with increased clonogenic survival. IL-6 combined with IR or Dex increased early intracellular pro-oxidant levels that were causally related to activation of NF-κB (nuclear factor κB) as determined by the ability of N-acetylcysteine to suppress both pro-oxidant levels and NF-κB activation. In myeloma cells, upon combination with hydrogen peroxide treatment, relative to TNF (tumour necrosis factor)-α, IL-6 induced an early perturbation in reduced glutathione level and increased NF-κB-dependent MnSOD (manganese superoxide dismutase) expression. Furthermore, knockdown of MnSOD suppressed the IL-6-induced myeloma cell resistance to radiation. MitoSOX Red staining showed that IL-6 treatment attenuated late mitochondrial oxidant production in irradiated myeloma cells. The present study provides evidence that increases in MnSOD expression mediate IL-6-induced resistance to Dex and radiation in myeloma cells. The results of the present study indicate that inhibition of antioxidant pathways could enhance myeloma cell responses to radiotherapy and/or chemotherapy.

Nordic Branding Podcast 5

DEFF Research Database (Denmark)

2017-01-01

'Hygge' is a concept that has generated much interest as a way of conceptualising 'Nordic living', e.g. in books on hygge or scented candles. In this Nordic Branding reflections podcast we are having a 'hyggelig' session with ph.d. Jeppe Trolle Linnet, reflecting on this concept and related 'Nord......' values. We met at Meyers Deli and The Laundromat Cafe (Copenhagen)....

Living with the New Nordic Diet

DEFF Research Database (Denmark)

Micheelsen, Arun; Holm, Lotte; Jensen, Katherine O'Doherty

2014-01-01

Purpose – Based on New Nordic Cuisine and Nordic dietary recommendations, the research centre OPUS has developed a healthy, sustainable and tasty New Nordic Diet (NND) with the goal of improving public health in Denmark. In order to determine the health potential of the NND, a six-month, controlled...... dietary intervention trial was conducted, in which participants procured NND foods at a specially designed intervention supermarket and prepared and consumed NND meals in their homes. The paper aims to discuss these issues. Design/methodology/approach – A qualitative sociological study was conducted among...... indicate that while the taste of the NND is likely to appeal to wider groups of consumers, the tasks of food procurement and preparation are likely to constitute barriers to its adoption. The strictly controlled intervention setting enabled participants to learn how to comply with dietary composition...

Myeloma cell-induced disruption of bone remodelling compartments leads to osteolytic lesions and generation of osteoclast-myeloma hybrid cells

DEFF Research Database (Denmark)

Andersen, Thomas L; Søe, Kent; Søndergaard, Teis Esben

2010-01-01

on the physical organisation of the myeloma cell microenvironment. The proximity between myeloma cells and osteoclasts or osteoblasts was shown to be conditioned by the recently discovered layer of flat cells that separates the osteoclasts and osteoblasts from the bone marrow, by forming a canopy over bone...

Interferon-alpha in the treatment of multiple myeloma

DEFF Research Database (Denmark)

Khoo, T.L.; Joshua, D.; Gibson, J.

2011-01-01

Interferons are soluble proteins produced naturally by cells in response to viruses. It has both anti-proliferative and immunomodulating properties and is one of the first examples of a biological response modifier use to treat the hematological malignancy multiple myeloma. Interferon has been used......-induction agent with other chemotherapy regimens, and as maintenance therapy after conventional chemotherapy or complete remission after autologous or allogeneic transplantation. Interferon as a single induction agent or co-induction agent with other chemotherapy agents appears only to have minimal benefit...... in myeloma. Its role as maintenance therapy in the plateau phase of myeloma also remains uncertain. More recently, the use of interferon must now compete with the "new drugs" - thalidomide, lenalidomide and bortezomib in myeloma treatment. Will there be a future role of interferon in the treatment...

The role of forests in climate change: Nordic experience

Energy Technology Data Exchange (ETDEWEB)

Portin, A.; Barua, S.; Clarke, M.; Camargo, M.; Viding, J.; Pekkanen, M.

2013-08-15

The objective of this project is to discuss the role of forests in Nordic countries in climate change mitigation and discuss the possible roles of forests as a part of a cost-effective climate policy. The report aims to provide a comprehensive and easily digestible way to better understand the issue. The report includes a discussion on the role of forests for enhancing carbon stocks and carbon sinks in the Nordic countries. The extent of above- and below-ground biomass and their role as forests carbon sinks in Nordic forests is analysed. The use of wood in products, buildings and as bioenergy is examined. Finally the report presents emissions trading schemes from around the globe that allow offsets and credits from forest projects on them and provides an analysis on the feasibility of such a scheme for the Nordic region. The report has been commissioned by the Working Group on Environment and Economics under the Nordic Council of Ministers. The study was carried out by Indufor. (Author)

Association of IgA multiple myeloma with pre-existing disease

Energy Technology Data Exchange (ETDEWEB)

Schafer, A.I.; Miller, J.B.

1979-01-01

A retrospective analysis of 153 patients with multiple myeloma was performed for evaluation of the possible significance of pre-existing disease. 37% of the group had no significant antecedent disorder. The most common prior illnesses were peptic ulcer disease and gallbladder disease. Of 12 patients in the group who had prior biliary tract disease and for whom immunoelectrophoretic studies were available, eight (66.7%) had IgA paraproteins. This figure is statistically higher than the 14.1% of prevalence of IgA paraproteins in those myeloma patients without biliary disease. We conclude that prior inflammatory gastrointestinal, pulmonary, and, particularly, biliary disease may be implicated in the pathogenesis of the IgA subset of multiple myeloma.

Clinical Application of {sup 18}F-FDG PET in Multiple Myeloma

Energy Technology Data Exchange (ETDEWEB)

Lee, Su Jin; Choi, Joon Young [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

2009-12-15

This review focuses on the clinical use of {sup 18}F-FDG PET to evaluate multiple myeloma. {sup 18}F-FDG PET is useful for diagnosis, staging of multiple myeloma and differential diagnosis of myeloma related disease such as monoclonal gammopathy of undetermined significance or plasmacytoma. For therapy response, {sup 18}F-FDG PET may be effective after chemotherapy for multiple myeloma and radiotherapy for plasmacytoma.

Energy economy in Nordic industry

Energy Technology Data Exchange (ETDEWEB)

Andersen, P H; Finnedal, B H

1980-01-01

The employment, economic and energetic situation in various industrial branches and their importance for industry as a whole is mapped for Nordic countries. Future Nordic energy projects can base their attempts to decrease energy costs per unit on this report. In food and stimulants industry, chemical, glass and ceramic industry over 90% energy is used for processing while in steel- and metal-industry the processing consumes only about 25%. Rentability of new investments in energy saving should be considered in these branches against investments in automation, new equipment etc. Common Nordic energy-saving projects can provide much better energy economy. For instance 4% of USA energy which had formerly been used in drying processes is drastically decreased and if the USA result can be transferred to Nordic conditions DKr 160 million can be save. Prospective common projects are process-types like drying, spray-drying, heat treatments of mineral proproducts, and evaporation.

Vocational education and training in the Nordic countries:

DEFF Research Database (Denmark)

Jørgensen, Christian Helms

2018-01-01

countries and the historical development of each of the four VET systems. This is followed by an examination of the role of VET in relation to the Nordic model of education and the Nordic labour market model. Finally, the position of VET in the Nordic transition systems is considered.......The chapter examines the systems of vocational education and training (VET) in four Nordic countries, Sweden, Finland, Norway and Denmark. First, it identifies the common political challenges for VET, which the following chapters of the book examine. Next, it outlines shared qualities of the Nordic...

A case of multiple myeloma presenting as a bullous dermatosis

Directory of Open Access Journals (Sweden)

Gul Ulker

2008-01-01

Full Text Available Multiple myeloma is a malignant plasma cell proliferative disorder that produces a monoclonal immunoglobulin protein. The skin involvement and the development of bullous disease are rarely seen features in multiple myeloma. We present a 55-year-old man with a longstanding, large, tense bullous eruption and hypertrophic scars over his body accompanied recently with weight loss and fatique. He had no response to the previous treatments, which included oral glucocorticoids and dapsone. Histologic examination of the lesions revealed subepidermal bullae, while no immunoflourescence staining was observed. In a further detailed labarotory examination, multiple myeloma was detected. After the treatment of multiple myeloma with chemotherapy, the lesions regressed. Patients with longstanding, recurrent, unusual bullous eruption should be investigated for the development of multiple myeloma.

Return to sender - American Images of the Nordic Welfare States and Nordic Welfare State Branding

DEFF Research Database (Denmark)

Marklund, C.; Petersen, Klaus

2013-01-01

In this article, we study the relationship between the United States of America and Norden, first showing how images of the Nordic model were constructed and reproduced in the United States from the 1920s until the 1960s. We find both utopias and dystopias in these narratives. Second, the article...... argues that these American images, narratives, and stereotypes did not only fulfill a function in the American debate, but were also relayed back to Norden, and affected debate, nation-branding strategies, and self-understandings there. During the Cold War, furthermore, the Nordic welfare state image...

Radiotherapy for solitary plasmacytoma and multiple myeloma

International Nuclear Information System (INIS)

Schmaus, M.C.; Neuhof, D.

2014-01-01

Solitary plasmacytoma and multiple myeloma require a differentiated radiotherapy. The irradiation for plasmacytoma with an adequate total dose (medullary 40-50 Gy or extramedullary 50-60 Gy) leads to a high degree of local control with a low rate of side effects. In cases of multiple myeloma radiotherapy will achieve effective palliation, both in terms of recalcification as well as reduction of neurological symptoms and analgesia. In terms of analgesia the rule is the higher the single dose fraction the faster the reduction of pain. As part of a conditioning treatment prior to stem cell transplantation radiotherapy contributes to the establishment of a graft versus myeloma effect (GVM). (orig.) [de

PET-CT for nuclear medicine diagnostics of multiple myeloma

International Nuclear Information System (INIS)

Dimitrakopoulou-Strauss, A.

2014-01-01

Functional or morphofunctional imaging modalities are used in myeloma patients for the diagnosis and therapy management within research protocols. Despite new staging criteria, which take into account the viability of a myeloma lesion, positron emission tomography (PET) is not used routinely. The impact of PET is therefore open. The role of PET and PET computed tomography (PET-CT) for the diagnosis and therapy management is discussed. The use of PET with 18F-fluorodeoxyglucose (FDG) allows the measurement of viable myeloma lesions and correlates with the stage of disease. A negative FDG examination correlates with a better prognosis. Furthermore, the number of focal lesions as well as the whole functional volume of myeloma lesions in FDG have a prognostic impact. Several studies have demonstrated the impact of FDG for the assessment of therapy monitoring and show that FDG is an earlier indicator for therapy response as compared to magnetic resonance imaging (MRI). The CT component of the new hybrid systems allows the assessment of osteolytic lesions in CT and their viability in FDG. The combination of PET with an MRT scanner allows the simultaneous measurement of bone marrow infiltration, focal lesions and their viability. The use of modern hybrid scanners, such as PET-CT and PET-MRT facilitates the simultaneous measurement of viable myeloma lesions, osteolytic lesions and bone marrow infiltration in the whole body; therefore, it is expected that these imaging modalities will play a greater role both in diagnosis and therapy management. (orig.) [de

Is Nordic Private Equity Different?

DEFF Research Database (Denmark)

Spliid, Robert

2013-01-01

Most research on private equity is based on American theory, tested on American empirical data. Nevertheless, the private equity concept has gained a solid foothold in the Nordic region, especially in Sweden. This article analyzes whether American-biased assumptions prevail in the Nordic countries...

Sequential hemi-body radiotherapy in advanced multiple myeloma

International Nuclear Information System (INIS)

Jaffe, J.P.; Bosch, A.; Raich, P.C.

1979-01-01

Eleven patients with advanced multiple myeloma refractory to standard chemotherapy were treated with a regimen of sequential hemi-body radiotherapy consisting of 800 rad midplane in a single dose to each half. 9/10 patients experienced significant relief of skeletal pain and there were 5/11 objective tumor responses with one complete remission. Treatment-related morbidity was significant and consisted primarily of nausea and emesis, bone marrow suppression, and pneumonitis. This therapy is helpful in the management of advanced myeloma, and should be studied earlier in the course of the disease

Positive findings on bone scan in multiple myeloma

International Nuclear Information System (INIS)

Lin Lin

2004-01-01

We report a case of multiple myeloma in which the CT only shows osteolytic lesions and MRI only shows compressive fractrue, but the scan shows some interesting imaging that make us to think of multiple myeloma. (authors)

A healthy Nordic diet and physical performance in old age: findings from the longitudinal Helsinki Birth Cohort Study.

Science.gov (United States)

Perälä, Mia-Maria; von Bonsdorff, Mikaela; Männistö, Satu; Salonen, Minna K; Simonen, Mika; Kanerva, Noora; Pohjolainen, Pertti; Kajantie, Eero; Rantanen, Taina; Eriksson, Johan G

2016-03-14

Epidemiological studies have shown that a number of nutrients are associated with better physical performance. However, little is still known about the role of the whole diet, particularly a healthy Nordic diet, in relation to physical performance. Therefore, we examined whether a healthy Nordic diet was associated with measures of physical performance 10 years later. We studied 1072 participants from the Helsinki Birth Cohort Study. Participants' diet was assessed using a validated 128-item FFQ at the mean age of 61 years, and a priori-defined Nordic diet score (NDS) was calculated. The score included Nordic fruits and berries, vegetables, cereals, PUFA:SFA and trans-fatty acids ratio, low-fat milk, fish, red and processed meat, total fat and alcohol. At the mean age of 71 years, participants' physical performance was measured using the Senior Fitness Test (SFT), and an overall SFT score was calculated. Women in the highest fourth of the NDS had on average 5 points higher SFT score compared with those in the lowest fourth (P for trend 0·005). No such association was observed in men. Women with the highest score had 17% better result in the 6-min walk test, 16% better arm curl and 20% better chair stand results compared with those with the lowest score (all P valueshealthy Nordic diet was associated with better overall physical performance among women and might help decrease the risk of disability in old age.

Thymidine secretion by hybridoma and myeloma cells

International Nuclear Information System (INIS)

Spilsberg, Bjorn; Rise, Frode; Petersen, Dirk; Nissen-Meyer, Jon

2006-01-01

Secretion of thymidine appeared to be a common property of hybridoma and myeloma cells, but not of other cell types, which were tested. Of three hybridoma cell lines tested, all secreted thymidine in amounts resulting in the accumulation of thymidine to concentrations of 10-20 μM in the culture medium. Also three of five myeloma cell lines that were analyzed secrete thymidine, but none of the other cell types that were studied. Thymidine was purified to homogeneity (4 mg purified from 3 l of culture medium) and identified as such by nuclear magnetic resonance spectroscopy. The cells that secreted thymidine showed high resistance to the growth inhibitory effect of thymidine

Dermatological moulage collections in the Nordic countries.

Science.gov (United States)

Worm, A-M; Sinisalo, H; Eilertsen, G; Åhrén, E; Meyer, I

2018-04-01

The art of producing and acquiring dermatological wax models, moulages, flourished all over Europe in the beginning of the twentieth century, whereas very little is known about the existence of moulage collections in the Nordic countries. The aim of this study was to elucidate the presence, the origin, the production place, the use and the condition of dermatological moulage collections in the Nordic countries. In each Nordic country, an extensive survey was undertaken during spring 2016. Dermatological departments, museums with medical collections, persons assumed to have specific information about wax moulages as well as secondary sources were contacted and interviewed. Several hitherto undescribed collections have survived in each country, most, however, damaged and in disrepair. One Danish and part of a Finnish collection have been restored. Only few moulages are exhibited and some have been photographed and digitalized. Denmark and Sweden have had a local moulage production. Responses to the survey indicate that the result covers all collections of dermatological moulages in the Nordic countries, though some moulages may remain in private collections unknown to the authors, or uncatalogued in museums. Moulages are medical gems from bygone days before modern technology facilitated new means of communication. Restoration and appropriate storing should be considered for at least selected items from the Nordic collections. © 2017 European Academy of Dermatology and Venereology.

Labour education the Nordic way

DEFF Research Database (Denmark)

Johansen, John Steen

2007-01-01

With its more than 75 years of experience, the Nordic Folk High School in Geneva has a strong tradition of labour education. Every year, about 35 trade union members from the Nordic countries take part in a course run alongside the International Labour Conference in Geneva....

Translocation t(11;14 (q13;q32 and genomic imbalances in multi-ethnic multiple myeloma patients: a Malaysian study

Directory of Open Access Journals (Sweden)

Ivyna Bong Pau Ni

2012-09-01

Full Text Available More than 50% of myeloma cases have normal karyotypes under conventional cytogenetic analysis due to low mitotic activity and content of plasma cells in the bone marrow. We used a polymerase chain reaction (PCR-based translocation detection assay to detect BCL1/JH t(11;14 (q13;q32 in 105 myeloma patients, and randomly selected 8 translocation positive samples for array comparative genomic hybridization (aCGH analysis. Our findings revealed 14.3% of myeloma samples were positive for BCL1/JH t(11;14 (q13;q32 translocation (n=15 of 105. We found no significant correlation between this translocation with age (P=0.420, gender (P=0.317, ethnicity (P=0.066 or new/relapsed status of multiple myeloma (P=0.412 at 95% confidence interval level by x2 test. In addition, aCGH results showed genomic imbalances in all samples analyzed. Frequent chromosomal gains were identified at regions 1q, 2q, 3p, 3q, 4p, 4q, 5q, 7q, 9q, 11q, 13q, 15q, 21q, 22q and Xq, while chromosomal losses were detected at 4q and 14q. Copy number variations at genetic loci that contain NAMPT, IVNS1ABP and STK17B genes are new findings that have not previously been reported in myeloma patients. Besides fluorescence in situ hybridization, PCR is another rapid, sensitive and simple technique that can be used for detecting BCL1/JH t(11;14(q13;q32 translocation in multiple myeloma patients. Genes located in the chromosomal aberration regions in our study, such as NAMPT, IVNS1ABP, IRF2BP2, PICALM, STAT1, STK17B, FBXL5, ACSL1, LAMP2, SAMSN1 and ATP8B4 might be potential prognostic markers and therapeutic targets in the treatment and management of multiple myeloma patients positive for BCL1/JH t(11;14 (q13;q32 translocation.

Holistic needs assessment in advanced, intensively treated multiple myeloma patients.

Science.gov (United States)

Boland, E G; Boland, J W; Ezaydi, Y; Greenfield, D M; Ahmedzai, S H; Snowden, J A

2014-10-01

It is recommended that patients with multiple myeloma should be assessed for unmet holistic needs at key times in their disease trajectory. The aim of this exploratory study was to characterise the holistic needs of advanced, intensively treated multiple myeloma using a structured assessment tool. Patients with multiple myeloma who had undergone a haematopoietic stem cell transplantation and subsequent treatment for at least one episode of progressive disease but were in stable plateau phase were included in the study. Patients' holistic needs were assessed using the self-reporting tool, Sheffield Profile for Assessment and Referral for Care (SPARC). Thirty-two patients with a median age of 60 years at assessment and a median of 5.5 years from diagnosis were recruited. Using the SPARC, half of the patients reported tiredness as 'quite a bit/very much,' while one third complained that daytime somnolence and insomnia were 'quite a bit/very much.' Forty-four percent of patients reported pain. One third of patients were bothered and distressed by the side effects from their treatment and were worried about long-term effects of their treatment. Thirty-one percent of patients felt that the effect of their condition had an impact on their sexual life, and 40 % were worried about the effect that their illness was having on their family or other people. This is the first study to use a self-reported holistic needs assessment tool in multiple myeloma. A multidimensional structured questionnaire like the SPARC could provide a useful first step in the effective delivery of supportive and palliative care for patients with multiple myeloma.

Burden of gout in the Nordic region, 1990-2015: findings from the Global Burden of Disease Study 2015.

Science.gov (United States)

Kiadaliri, A A; Uhlig, T; Englund, M

2018-01-29

To explore the burden of gout in the Nordic region, with a population around 27 million in 2015 distributed across six countries. We used the findings of the 2015 Global Burden of Diseases study to report prevalence and disability associated with gout in the Nordic region. From 1990 to 2015, the number of prevalent gout cases rose by 30% to 252 967 [95% uncertainty interval (UI) 223 478‒287 288] in the Nordic region. In 2015, gout contributed to 7982 (95% UI 5431‒10 800) years lived with disability (YLDs) in the region, an increase of 29% (95% UI 24‒35%) from 1990. While the crude YLD rate of gout increased by 12.9% (95% UI 7.8‒18.1%) between 1990 and 2015, the age-standardized YLD rate remained stable. Gout was ranked as the 63rd leading cause of total YLDs in the region in 2015, with the highest rank in men aged 55-59 years (38th leading cause of YLDs). The corresponding rank at the global level was 94. Of 195 countries studied, four Nordic countries [Greenland (2nd), Iceland (12th), Finland (14th), and Sweden (15th)] were among the top 15 countries with the highest age-standardized YLD rate of gout. The burden of gout is rising in the Nordic region. Gout's contribution to the total burden of diseases in the region is more significant than the global average. Expected increases in gout burden owing to population growth and ageing call for stronger preventive and therapeutic strategies for gout management in Nordic countries.

Nordic Experiences: Participants' Expectations and Experiences of Short-Term Study Abroad Programs

Science.gov (United States)

Rahikainen, Katariina; Hakkarainen, Kai

2013-01-01

The purpose of this study was to investigate Finnish high school students' and teachers' perceptions of the effects of short-term Nordic study abroad programs in which they had participated. The data presented were based on a "mixed-methods strategy." The data set consisted of responses from 158 students and 92 teachers to a specifically…

Induction of potent NK cell-dependent anti-myeloma cytotoxic T cells in response to combined mapatumumab and bortezomib.

Science.gov (United States)

Neeson, Paul J; Hsu, Andy K; Chen, Yin R; Halse, Heloise M; Loh, Joanna; Cordy, Reece; Fielding, Kate; Davis, Joanne; Noske, Josh; Davenport, Alex J; Lindqvist-Gigg, Camilla A; Humphreys, Robin; Tai, Tsin; Prince, H Miles; Trapani, Joseph A; Smyth, Mark J; Ritchie, David S

2015-09-01

There is increasing evidence that some cancer therapies can promote tumor immunogenicity to boost the endogenous antitumor immune response. In this study, we used the novel combination of agonistic anti-TRAIL-R1 antibody (mapatumumab, Mapa) with low dose bortezomib (LDB) for this purpose. The combination induced profound myeloma cell apoptosis, greatly enhanced the uptake of myeloma cell apoptotic bodies by dendritic cell (DC) and induced anti-myeloma cytotoxicity by both CD8 + T cells and NK cells. Cytotoxic lymphocyte expansion was detected within 24 h of commencing therapy and was maximized when myeloma-pulsed DC were co-treated with low dose bortezomib and mapatumumab (LDB+Mapa) in the presence of NK cells. This study shows that Mapa has two distinct but connected modes of action against multiple myeloma (MM). First, when combined with LDB, Mapa produced powerful myeloma cell apoptosis; secondly, it promoted DC priming and an NK cell-mediated expansion of anti-myeloma cytotoxic lymphocyte (CTL). Overall, this study indicates that Mapa can be used to drive potent anti-MM immune responses.

Role of Bruton's tyrosine kinase (BTK) in growth and metastasis of INA6 myeloma cells

International Nuclear Information System (INIS)

Bam, R; Venkateshaiah, S U; Khan, S; Ling, W; Randal, S S; Li, X; Zhang, Q; Rhee, F van; Barlogie, B; Epstein, J; Yaccoby, S

2014-01-01

Bruton's tyrosine kinase (BTK) and the chemokine receptor CXCR4 are linked in various hematologic malignancies. The aim of the study was to understand the role of BTK in myeloma cell growth and metastasis using the stably BTK knockdown luciferase-expressing INA6 myeloma line. BTK knockdown had reduced adhesion to stroma and migration of myeloma cells toward stromal cell-derived factor-1. BTK knockdown had no effect on short-term in vitro growth of myeloma cells, although clonogenicity was inhibited and myeloma cell growth was promoted in coculture with osteoclasts. In severe combined immunodeficient-rab mice with contralaterally implanted pieces of bones, BTK knockdown in myeloma cells promoted their proliferation and growth in the primary bone but suppressed metastasis to the contralateral bone. BTK knockdown myeloma cells had altered the expression of genes associated with adhesion and proliferation and increased mammalian target of rapamycin signaling. In 176 paired clinical samples, BTK and CXCR4 expression was lower in myeloma cells purified from a focal lesion than from a random site. BTK expression in random-site samples was correlated with proportions of myeloma cells expressing cell surface CXCR4. Our findings highlight intratumoral heterogeneity of myeloma cells in the bone marrow microenvironment and suggest that BTK is involved in determining proliferative, quiescent or metastatic phenotypes of myeloma cells

Trading electricity outside the Nordic countries

International Nuclear Information System (INIS)

1994-01-01

The subject of transborder trade of electricity between the Nordic countries and other North-European countries is dealt with. A detailed comparison of generating capacity, generating costs as well as electricity prices, market structure and national and international regulations is given. This shows that generating costs in the Nordic countries in general are lower than those in other North-European countries. This indicates a potential for transborder trade. Norway has a potential for exporting power while Denmark and Sweden have a potential for energy exports due to current excess capacity. Transmission capacity from the Nordic countries to Germany is limited. As access to the German transmission network is restricted, conditions for trade depend on differences between marginal cost. After transmission cost, those differences do not finance larger investments in further capacity. A change in the market structure in Germany with third party access to the transmission network will allow major consumers to buy directly from producers in the Nordic countries. An opening up of the market should reduce the price load in Germany. This could cause price increases in the Nordic countries. (AB)

EDITORIAL The 23rd Nordic Semiconductor Meeting The 23rd Nordic Semiconductor Meeting

Science.gov (United States)

Ólafsson, Sveinn; Sveinbjörnsson, Einar

2010-12-01

A Nordic Semiconductor Meeting is held every other year with the venue rotating amongst the Nordic countries of Denmark, Finland, Iceland, Norway and Sweden. The focus of these meetings remains 'original research and science being carried out on semiconductor materials, devices and systems'. Reports on industrial activity have usually featured. The topics have ranged from fundamental research on point defects in a semiconductor to system architecture of semiconductor electronic devices. Proceedings from these events are regularly published as a topical issue of Physica Scripta. All of the papers in this topical issue have undergone critical peer review and we wish to thank the reviewers and the authors for their cooperation, which has been instrumental in meeting the high scientific standards and quality of the series. This meeting of the 23rd Nordic Semiconductor community, NSM 2009, was held at Háskólatorg at the campus of the University of Iceland, Reykjavik, Iceland, 14-17 June 2009. Support was provided by the University of Iceland. Almost 50 participants presented a broad range of topics covering semiconductor materials and devices as well as related material science interests. The conference provided a forum for Nordic and international scientists to present and discuss new results and ideas concerning the fundamentals and applications of semiconductor materials. The meeting aim was to advance the progress of Nordic science and thus aid in future worldwide technological advances concerning technology, education, energy and the environment. Topics Theory and fundamental physics of semiconductors Emerging semiconductor technologies (for example III-V integration on Si, novel Si devices, graphene) Energy and semiconductors Optical phenomena and optical devices MEMS and sensors Program 14 June Registration 13:00-17:00 15 June Meeting program 09:30-17:00 and Poster Session I 16 June Meeting program 09:30-17:00 and Poster Session II 17 June Excursion and dinner

What Characterise the Nordic Welfare State Model

DEFF Research Database (Denmark)

Greve, Bent

2007-01-01

The main distinctive characteristics of the Nordic welfare states are presented. These include full employment, high degree of equality, a high level of taxes and public sector spending. The Nordic countries are compared to other European countries. The conclusion being that the Nordic Model...... is here to stay, although a movement in a European direction is underway....

Nordic research in logistics and supply chain management

DEFF Research Database (Denmark)

Arlbjørn, Jan Stentoft; Jonsson, Patrik; Johansen, John

2008-01-01

Purpose - The purpose of this data-based analysis is to report and reflect on the characteristics of the academic discipline concerned with logistics and supply chain management (SCM) as it is conducted in the Nordic countries (Denmark, Finland, Iceland, Norway and Sweden). The paper further seeks...... returned, the response rate was 41 per cent. Findings - The study did not provide a clear picture of a distinct Nordic research paradigm applying to the study of logistics and SCM. The analysis shows as characteristic of research issues pursued by Nordic researchers the focus on supply chains and networks...... with research in the field and external funding. Research limitations/implications - The research reported here may help individual researchers raise their consciousness about their own research. Originality/value - This is the first empirical study to analyze research paradigms within logistics and SCM...

Modern imaging techniques in patients with multiple myeloma

International Nuclear Information System (INIS)

Bannas, Peter; Adam, G.; Derlin, T.; Kroeger, N.

2013-01-01

Imaging studies are essential for both diagnosis and initial staging of multiple myeloma, as well as for differentiation from other monoclonal plasma cell diseases. Apart from conventional radiography, a variety of newer imaging modalities including whole-body low-dose-CT, whole-body MRI and 18F-FDG PET/CT may be used for detection of osseous and extraosseous myeloma manifestations. Despite of known limitations such as limited sensitivity and specificity and the inability to detect extraosseous lesions, conventional radiography still remains the gold standard for staging newly diagnosed myeloma, partly due to its wide availability and low costs. Whole-body low-dose CT is increasingly used due to its higher sensitivity for the detection of osseous lesions and its ability to diagnose extraosseous lesions, and is replacing conventional radiography at selected centres. The highest sensitivity for both detection of bone marrow disease and extraosseous lesions can be achieved with whole-body MRI or 18F-FDG PET/CT. Diffuse bone marrow infiltration may be visualized by whole-body MRI with high sensitivity. Whole-body MRI is at least recommended in all patients with normal conventional radiography and in all patients with an apparently solitary plasmacytoma of bone. To obtain the most precise readings, optimized examination protocols and dedicated radiologists and nuclear medicine physicians familiar with the complex and variable morphologies of myeloma lesions are required. (orig.)

Implementation Plan for a Common Nordic Retail Market

Energy Technology Data Exchange (ETDEWEB)

2010-09-15

For several years NordREG has been working to promote and facilitate a common Nordic end user market. Given the political support that was expressed at the meeting of the Nordic energy ministers in the autumn of 2009, the work has become even more concrete. With this implementation plan, NordREG outlines what should be done, by whom and when in order to create a common Nordic end user market over the coming years. As the plan shows the need for contributed efforts from all stakeholders will be vital in the coming years in order to make a reality of the plans of creating a common Nordic end user market. The transition from national retail markets to a single Nordic market will take a great deal of work from regulators, DSOs, suppliers and TSOs. The benefits that a single Nordic end user market will bring will however make it worthwhile. In the long run, the integrated Nordic end user market will be a more efficient solution than keeping the four national markets. This is also a step towards the integration of European markets. The process of creating a single Nordic market also brings a unique opportunity to find new efficient solutions on different issues. Hence, the goal is not only to integrate the Nordic end user markets, but rather to develop a more customer oriented market with a high degree of competition between the suppliers

Imaging spectrum in sclerotic myelomas: an experience of three cases

International Nuclear Information System (INIS)

Grover, S.B.; Dhar, A.

2000-01-01

The classic radiographic presentation of multiple myeloma is lytic skeletal lesions. Primary sclerotic manifestations are rare and occur only in 3 % of cases. The imaging spectrum in three cases of multiple myeloma with primary osteosclerosis is described. The first patient had spiculated sclerosis of the orbit, which is an uncommon site for myeloma. The second patient with POEMS syndrome had multiple, scattered, skeletal lesions with sclerotic margins. The third patient presented with a chest wall mass and had an expansile thick spiculated sclerosis in the rib. The wide imaging spectrum possible in sclerotic myelomas and their relevant differential diagnosis is emphasized. (orig.)

Lutheranism and the Nordic States

DEFF Research Database (Denmark)

Buchardt, Mette

2017-01-01

The Reformation in the Nordic region – today consisting of Island, Norway, Denmark, Sweden and Finland – was Lutheran and state driven. This chapter addresses the question of Nordic forms of Lutheranism as well as the question of the impact of Lutheranism in the North by focusing on the relation...

Heparanase promotes myeloma progression by inducing mesenchymal features and motility of myeloma cells.

Science.gov (United States)

Li, Juan; Pan, Qianying; Rowan, Patrick D; Trotter, Timothy N; Peker, Deniz; Regal, Kellie M; Javed, Amjad; Suva, Larry J; Yang, Yang

2016-03-08

Bone dissemination and bone disease occur in approximately 80% of patients with multiple myeloma (MM) and are a major cause of patient mortality. We previously demonstrated that MM cell-derived heparanase (HPSE) is a major driver of MM dissemination to and progression in new bone sites. However the mechanism(s) by which HPSE promotes MM progression remains unclear. In the present study, we investigated the involvement of mesenchymal features in HPSE-promoted MM progression in bone. Using a combination of molecular, biochemical, cellular, and in vivo approaches, we demonstrated that (1) HPSE enhanced the expression of mesenchymal markers in both MM and vascular endothelial cells; (2) HPSE expression in patient myeloma cells positively correlated with the expression of the mesenchymal markers vimentin and fibronectin. Additional mechanistic studies revealed that the enhanced mesenchymal-like phenotype induced by HPSE in MM cells is due, at least in part, to the stimulation of the ERK signaling pathway. Finally, knockdown of vimentin in HPSE expressing MM cells resulted in significantly attenuated MM cell dissemination and tumor growth in vivo. Collectively, these data demonstrate that the mesenchymal features induced by HPSE in MM cells contribute to enhanced tumor cell motility and bone-dissemination.

Multiple myeloma and plasmacytomas

International Nuclear Information System (INIS)

Mill, W.B.; Wasserman, T.H.

1987-01-01

Radiation therapy is the primary modality of treatment in the management of solitary plasmacytomas. The dose of radiation recommended is 5500 to 6000 cGy in 6 to 8 weeks. Disseminated myeloma is primarily treated with chemotherapy, which frequently includes melphalan and prednisone. Other drugs that are active in this disease are cyclophophamide, vincristine, procarbazine, BCNU, and doxorubicin. Adjuvant radiation therapy is indicated for painful bone lesions, for prevention and treatment of pathologic features of long bones, for spinal cord compression, and to relieve pressure from soft tissue masses. Myeloma is a relatively radiosensitive tumor requiring only 1000 to 2000 cGy in 1 to 2 weeks to relieve most painful lesions

Curability of Multiple Myeloma

Directory of Open Access Journals (Sweden)

Raymond Alexanian

2012-01-01

Full Text Available Among 792 patients with multiple myeloma treated from 1987 to 2010 and assessed after 18 months, there were 167 patients with complete remission. For those 60 patients treated between 1987–1998 and with long followup, the latest relapse occurred after 11.8 years, so that 13 patients have remained in sustained complete remission for longer than 12 years (range 12–22 years. These results suggest that 3% of all patients treated during that period may be cured of multiple myeloma. In addition to immunofixation, more sensitive techniques for the detection of residual disease should be applied more consistently in patients with apparent complete remission in order to identify those with potential cure.

Vocational education in the Nordic countries

DEFF Research Database (Denmark)

a common heritage in education policy. This volume will help strengthen the knowledge base required for transnational policy learning, and for developing vocational education internationally for the future. As a result, the book will be of interest to researchers, academics and postgraduate students......Vocational Education in the Nordic Countries: Learning from Diversity is the second of two books that disseminates new and systematic knowledge on the strengths and weaknesses of the different models of vocational education and training (VET) in four Nordic countries. Vocational education in Europe...... involved in the study of vocational education, educational studies and educational policy, as well as policy makers....

Whole body MR in patients with multiple myeloma

International Nuclear Information System (INIS)

Piekarek, A.; Sosnowski, P.; Nowicki, A.; Komarnicki, M.

2009-01-01

Background: Multiple myeloma is a cancer of plasma cells which leads to bone marrow infiltration. Aim: Whole-body MR is the most sensitive imaging method available to detect multiple myeloma lesions. Ma terial and methods: MR scans were performed in 100 patients with multiple myeloma who were receiving treatment in the Haematology Clinic in Poznan in the years 2005 - 2006. Whole-body MR scans were performed with general coil 1.0 T in STIR sequences and T1 sequences, in coronal and sagittal planes with scanning area covering the head, neck, trunk and the limbs (FOV for specific regions was 36 -48 cm). The bone lesions were classified as focal (monofocal/multifocal lesions), infiltrative, mixed and 'salt and pepper' type. Depending on the size of the lesions the patients were included in one of three groups according to Salmon-Durie Plus classification. Results: Four main types of multiple myeloma were distinguished based on MR scans: focal (48 patients; monofocal in 10 patients), infiltrative (17 patients), mixed type (19 patients) and 'salt and pepper' type (4 patients). The remaining 12 patients had no multiple myeloma lesions in the bone marrow. Additionally, in 18% of patients a soft tissue mass could be observed. According to Salmon-Durie Plus categorisation 27 subjects were classified as having stage I, 16 patients stage and 57 patients stage III disease. In 12% of patients MR data changed the disease staging. Conclusions: WB MR is a sensitive and effective diagnostic method with an important impact on staging and further treatment of multiple myeloma. (authors)

Novel human multiple myeloma cell line UHKT-893

Czech Academy of Sciences Publication Activity Database

Uherková, L.; Vančurová, I.; Vyhlídalová, I.; Pleschnerová, M.; Špička, I.; Mihalová, R.; Březinová, J.; Hodný, Zdeněk; Čermáková, K.; Polanská, V.; Marinov, I.; Jedelský, P.L.; Kuželová, K.; Stöckbauer, P.

2013-01-01

Roč. 37, č. 3 (2013), s. 320-326 ISSN 0145-2126 Institutional support: RVO:68378050 Keywords : human myeloma cell line * human multiple myeloma * plasma cell * IL-6 dependence * immunoglobulin * free light chain Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.692, year: 2013

Nordic Noir Production Values

DEFF Research Database (Denmark)

Waade, Anne Marit; Jensen, Pia Majbritt

2013-01-01

In this article the authors argue that Nordic noir constitutes a set of production values utilised and conceptualised to make Danish television series attractive in the international market. The idea of production values is embedded into a media industrial context where market principles of target...... by relating the specific Nordic noir production values present in the two series to changing conditions in Danish television drama production, in particular the internationalisation of DR’s Drama Division....

Cold atmospheric plasma as a potential tool for multiple myeloma treatment

Science.gov (United States)

Cui, Qingjie; Liu, Dingxin; Liu, Zhijie; Wang, Xiaohua; Yang, Yanjie; Feng, Miaojuan; Liang, Rong; Chen, Hailan; Ye, Kai; Kong, Michael G.

2018-01-01

Multiple myeloma (MM) is a fatal and incurable hematological malignancy thus new therapy need to be developed. Cold atmospheric plasma, a new technology that could generate various active species, could efficiently induce various tumor cells apoptosis. More details about the interaction of plasma and tumor cells need to be addressed before the application of gas plasma in clinical cancer treatment. In this study, we demonstrate that He+O2 plasma could efficiently induce myeloma cell apoptosis through the activation of CD95 and downstream caspase cascades. Extracellular and intracellular reactive oxygen species (ROS) accumulation is essential for CD95-mediated cell apoptosis in response to plasma treatment. Furthermore, p53 is shown to be a key transcription factor in activating CD95 and caspase cascades. More importantly, we demonstrate that CD95 expression is higher in tumor cells than in normal cells in both MM cell lines and MM clinical samples, which suggests that CD95 could be a favorable target for plasma treatment as it could selectively inactivate myeloma tumor cells. Our results illustrate the molecular details of plasma induced myeloma cell apoptosis and it shows that gas plasma could be a potential tool for myeloma therapy in the future. PMID:29719586

Multiple myeloma in a captive lion (Panthera leo

Directory of Open Access Journals (Sweden)

Adrian S.W. Tordiffe

2013-09-01

Full Text Available Multiple myeloma is a rare, systemic proliferation of neoplastic plasma cells. A case was reported in an 11-year-old male captive lion (Panthera leo at the National Zoological Gardens of South Africa, Pretoria. The classic features of symptomatic multiple myeloma were all evident in this case; namely osteolytic lesions, monoclonal gammopathy in the serum with excretion of monoclonal proteins in the urine, neoplastic plasma cells in the bone marrow and associated renal failure and anaemia. In addition, similar to the common pattern of this disease in domestic felids, at least three extramedullary tumours were found and several organs were infiltrated by neoplastic plasma cells. The cytoplasm of approximately 50%of the neoplastic round cells, including a few giant myeloma cells, stained weakly to strongly using immunohistochemical stains for B-lymphocytes (CD79a. The normal haematological parameters and lack of any osteolytic lesions in the lion at the time of the first evaluation suggest that the primary neoplastic cells could have originated from one of the extramedullary tumour sites. Only two cases of multiple myeloma have previously been reported in captive wild felids. To the authors’ knowledge, there are no case reports of multiple myeloma in lions.

The Reinvention of Nordic Terroir and the Making of Gastrotourism Places

DEFF Research Database (Denmark)

Gyimóthy, Szilvia

contributed to the mediatization of Nordic regional gastronomy. But how can we conceptualize contemporary food place promotion strategies the Nordic context, in which terroir was virtually absent before 2004 (the year when the New Nordic Cuisine manifesto was issued)? To address the question, this paper...... studies place branding narratives that mobilize local food and contemporary gastronomic trends by revisiting the notion of terroir (taste of place) as a strategic marketing asset. In particular, it explores how rural tourism destinations with little or no gastronomic heritage exploit the discourses of New...... Nordic Food to create a distinct sense of place. An extensive review of the literature identifies two conservationist strategies by which terroir narratives are constructed (accreditation and patrimonialization), neither of which fully capturing the particular rhetoric approaches shaping the Nordic...

Cohort Fertility Patterns in the Nordic Countries

Directory of Open Access Journals (Sweden)

Gunnar Andersson

2009-04-01

Full Text Available Previous analyses of period fertility suggest that the trends of the Nordic countries are sufficiently similar to speak of a common "Nordic fertility regime". We investigate whether this assumption can be corroborated by comparing cohort fertility patterns in the Nordic countries. We study cumulated and completed fertility of Nordic birth cohorts based on the childbearing histories of women born in 1935 and later derived from the population registers of Denmark, Finland, Norway, and Sweden. We further explore childbearing behaviour by women's educational attainment. The results show remarkable similarities in postponement and recuperation between the countries and very small differences in completed fertility across educational groups. Median childbearing age is about 2-3 years higher in the 1960-64 cohort than in the 1950-54 cohort, but the younger cohort recuperates the fertility level of the older cohort at ages 30 and above. A similar pattern of recuperation can be observed for highly educated women as compared to women with less education. An interesting finding is that of a positive relationship between educational level and the final number of children when women who become mothers at similar ages are compared. Country differences in fertility outcome are generally rather low. Childlessness is highest in Finland and lowest in Norway, and the educational differentials are largest in Norway. Despite such differences, the cohort analyses in many ways support the notion of a common Nordic fertility regime.

Democracy, Caring and Competence: Values Perspectives in ECEC Curricula in the Nordic Countries

Science.gov (United States)

Einarsdottir, Johanna; Purola, Anna-Maija; Johansson, Eva Marianne; Broström, Stig; Emilson, Anette

2015-01-01

The aim of the study is to explore how Nordic Early Childhood Education and Care policies frame values education in preschools with a special focus on the values of democracy, caring and competence. The study is part of a larger Nordic project, "Values education in Nordic preschools: Basis of education for tomorrow," the aim of which is…

Effects of an isocaloric healthy Nordic diet on ambulatory blood pressure in metabolic syndrome: a randomized SYSDIET sub-study.

Science.gov (United States)

Brader, L; Uusitupa, M; Dragsted, L O; Hermansen, K

2014-01-01

Dietary pattern is central in the prevention of hypertension and blood pressure (BP)-related diseases. A diet based on healthy Nordic foods may have a favourable impact on BP. The objective was to clarify whether a Nordic alternative for a healthy food pattern would have beneficial effects on ambulatory BP in subjects with metabolic syndrome (MetS). In total, 37 subjects were randomized to either a healthy Nordic diet or a control diet. A healthy Nordic diet embraced whole grains, rapeseed oil, berries, fruits, vegetables, fish, nuts and low-fat dairy products of Nordic origin. The mean nutrient intake in the Nordic countries formed the control diet, embracing wheat products, dairy fat-based spread and a lower intake of fruits, vegetables and fish. Diets were isoenergetic. Ambulatory BP was monitored and 24-h urine was collected before and after 12 weeks of intervention. After 12 weeks, ambulatory diastolic BP (-4.4 mm Hg; P=0.001) and mean arterial pressure (-4.2 mm Hg; P=0.006) were lowered by the healthy Nordic diet compared with the control diet, whereas changes in ambulatory systolic BP did not differ significantly between diets (-3.5 mm Hg; P=0.122). Heart rate tended to be lower in those on the healthy Nordic diet (P=0.057). Urinary sodium and potassium excretions were unaffected by diets and consequently not associated with the healthy Nordic diet-induced lowering of BP. Consumption of Nordic varieties of health-enhancing foods for 12 weeks decreased diastolic ambulatory BP and mean arterial pressure in subjects with features of MetS during weight-stable condition, suggesting beneficial effects of a healthy Nordic dietary pattern on ambulatory BP.

Language attitudes and the ideology of the Nordic

DEFF Research Database (Denmark)

Thøgersen, Jacob Martin; Östman, Jan Ola

2010-01-01

This article discusses the rise and the current standing of “Norden” (the Nordic societies) as an imagined community (Anderson, Imagined communities, Verso, 1991). The ideology of Norden as a coherent community rests on the one hand on the perceived mutual intelligibility of the Scandinavian...... languages, used as mother tongue or as lingua franca. On the other hand the ideology of Norden rests on a sense of historical unity. Historically, the ideology of the Nordic grew out of the era of national romanticism. The present study therefore addresses the pertinent question of how the ideology...... of the Nordic fares in late modernity where ideology is under threat from more “rational”, e.g., financial lines of thinking....

The Nordic Countries interests in principles for international greenhouse gas agreements

International Nuclear Information System (INIS)

Halsnaes, K.; Meyer, H.; Stephensen, P.; Soerensen, L.

1995-01-01

The focus of this report is the interests of the Nordic countries in international agreements on greenhouse gases. The subject is approached mainly from an economic point of view. Introductory, the climate convention are described, with special attention to obligations to emission reductions. Important discussion points are timing of the reductions as well as the question of meeting the reductions by cooperation with other countries through joint-implementation projects. The different attitudes of the Nordic countries to these issues are discussed. In the following, the technical and economic possibilities for meeting the reduction objectives of each country are described. For this purpose, governmental plans and studies (on bottom-up as well as top-down studies) are brought into focus. A discussion of the differences and similarities of the methodology of the studies are carried out. Finally, the report focuses on costs of reducing emissions in the Nordic countries. A comparison between the different Nordic countries, as well as between the Nordic countries and the other OECD countries is done. The analysis points out, that the Nordic countries are characterized by relatively high costs in general. Another conclusion is, that the costs of reduction after the year 2000/2005 are much lower than costs of reductions in the short run. An exception to this is Denmark. This points out, that some Nordic countries prefer emission reductions through joint-implementation projects in other countries, rather than reductions through restrictive agreements in the sort run. (au) (29 tabs., 28 ills., 45 refs.)

The Role of Immunotherapy in Multiple Myeloma

Directory of Open Access Journals (Sweden)

Mehmet Kocoglu

2016-01-01

Full Text Available Multiple myeloma is the second most common hematologic malignancy. The treatment of this disease has changed considerably over the last two decades with the introduction to the clinical practice of novel agents such as proteasome inhibitors and immunomodulatory drugs. Basic research efforts towards better understanding of normal and missing immune surveillence in myeloma have led to development of new strategies and therapies that require the engagement of the immune system. Many of these treatments are under clinical development and have already started providing encouraging results. We, for the second time in the last two decades, are about to witness another shift of the paradigm in the management of this ailment. This review will summarize the major approaches in myeloma immunotherapies.

Recent advances in understanding multiple myeloma [version 1; referees: 4 approved

Directory of Open Access Journals (Sweden)

Binod Dhakal

2016-08-01

Full Text Available There have been major recent advancements in the understanding and management of multiple myeloma. Diagnostic criteria have been revised and former ultra-high-risk smoldering multiple myeloma is now considered multiple myeloma in need of treatment. Understanding clonal progression, evolution, and tides not only has helped elucidate the disease behavior but might help expand therapeutic choices in order to select appropriate treatment for patients. Unprecedented response rates with modern triplet induction therapies containing proteasome inhibitor and immunomodulators have made this approach standard for initial treatment. The US Food and Drug Administration approved four new drugs (two targeted antibodies and two oral agents in 2015 in relapsed/refractory multiple myeloma and these drugs along with the other already-available drugs have now increased the choices of regimens. Even drugs without single-agent activity, such as panobinostat and elotuzumab, have an important role, especially in the proteasome inhibitor refractory setting. Recent studies done in the context of novel agent induction suggest that high-dose therapy followed by autologous transplant continues to improve response rates and progression-free survival, thus underscoring their role in transplant-eligible patients. Evolving paradigms in the treatment of multiple myeloma include newer promising immune approaches, such as adoptive cellular therapies, vaccines, or antibody-based immune manipulations. Though multiple myeloma is still considered incurable, it is clear that with the improved understanding of disease biology and clonal architecture of relapse combined with the availability of multi-targeted approaches, we are ever closer to a lasting cure or transformation into indolent and long-lasting disease courses or both.

Nordic Walking and chronic low back pain: design of a randomized clinical trial

Directory of Open Access Journals (Sweden)

Hartvigsen Jan

2006-10-01

Full Text Available Abstract Background Low Back Pain is a major public health problem all over the western world. Active approaches including exercise in the treatment of low back pain results in better outcomes for patients, but it is not known exactly which types of back exercises are most beneficial or whether general physical activity provide similar benefits. Nordic Walking is a popular and fast growing type of exercise in Northern Europe. Initial studies have demonstrated that persons performing Nordic Walking are able to exercise longer and harder compared to normal walking thereby increasing their cardiovascular metabolism. Until now no studies have been performed to investigate whether Nordic Walking has beneficial effects in relation to low back pain. The primary aim of this study is to investigate whether supervised Nordic Walking can reduce pain and improve function in a population of chronic low back pain patients when compared to unsupervised Nordic Walking and advice to stay active. In addition we investigate whether there is an increase in the cardiovascular metabolism in persons performing supervised Nordic Walking compared to persons who are advised to stay active. Finally, we investigate whether there is a difference in compliance between persons receiving supervised Nordic Walking and persons doing unsupervised Nordic Walking. Methods One hundred and fifty patients with low back pain for at least eight weeks and referred to a specialized secondary sector outpatient back pain clinic are included in the study. After completion of the standard back centre treatment patients are randomized into one of three groups: A Nordic Walking twice a week for eight weeks under supervision of a specially trained instructor; B Unsupervised Nordic Walking for eight weeks after one training session with an instructor; C A one hour motivational talk including advice to stay active. Outcome measures are pain, function, overall health, cardiovascular ability and

Studies on the antigenic properties of the Fd-fragment of a human G-myeloma protein (Daw)

NARCIS (Netherlands)

Zegers, Ben J.M.; Ballieux, R.E.

The present investigation deals with an immunochemical approach in studies on the structure of Fd-fragments of human immunoglobulins. Rabbits were immunized with a preparation of Fd-fragment of a human G-myeloma protein (Daw) [1]. Detailed studies on the reactions of the rabbit antiserum with a

New New Nordic Branding

DEFF Research Database (Denmark)

Andersen, Lars Pynt

2017-01-01

Konstruktionen af nordisk regionalisme er en stærk tendens som udgangspunkt for Nordic branding, men har vi egentlig forstået de værdier og spændinger, der driver hele projektet om en ny ’nordiskhed’?......Konstruktionen af nordisk regionalisme er en stærk tendens som udgangspunkt for Nordic branding, men har vi egentlig forstået de værdier og spændinger, der driver hele projektet om en ny ’nordiskhed’?...

Pathological study of multiple myeloma in atomic bomb survivors

Energy Technology Data Exchange (ETDEWEB)

Takaki, Y.; Kishikawa, M.; Bundo, K. (Nagasaki Univ. (Japan). School of Medicine)

1980-11-01

Pathological records of autopsies carried out in Nagasaki from '46 to '77 were reviewed. Of 9331 autopsies, 5787 were unexposed cases and were used as a control. 9.2% of the deaths were due to hematologic disorders. There was no evidence that the incidence of multiple myeloma among a-bomb survivors increased compared with the control. The incidences of leukemia, lymphoma and aplastic anemia were also listed.

The Nordic safety program on accident consequence assessment

International Nuclear Information System (INIS)

Tveten, U.

1988-01-01

One important part of Nordic cooperation is partially funded by the Nordic Council of Ministers, namely the work performed within the Nordic Safety Program (often referred to as the NKA projects). NKA is the Nordic abbreviation of the Nordic Liaison Committee on Atomic Energy. One program area in the present four-year period is concerned with problems related to reactor accident consequence assessment, and contains almost twenty projects covering a wide range of subjects. The author is program coordinator for this program area. The program will be completed in 1989. The program was strongly influenced by Chernobyl, and a number of new projects were included in the program in 1986. Involved in the program are these Nordic institutions: Riso National Laboratory (Denmark). Technical Research Centre of Finland. Finnish Centre for Radiation and Nuclear Safety. Finnish Meteorological Institute. Institute for Energy Technology (Norway). Agricultural University of Norway. Meteorological Institute of Norway. Studsvik Energiteknik AB (Sweden). National Defence Research Laboratory (Sweden)

Racial disparities in incidence and outcome in multiple myeloma: a population-based study

OpenAIRE

Waxman, Adam J.; Mink, Pamela J.; Devesa, Susan S.; Anderson, William F.; Weiss, Brendan M.; Kristinsson, Sigurdur Y.; McGlynn, Katherine A.; Landgren, Ola

2010-01-01

Multiple myeloma (MM) is the most common hematologic malignancy in blacks. Some prior studies suggest inferior survival in blacks; others suggest similar survival. Using the original 9 Surveillance, Epidemiology, and End Results registries, we conducted a large-scale population-based study including 5798 black and 28 939 white MM patients diagnosed 1973-2005, followed through 2006. Age-adjusted incidence rates, disease-specific survival, and relative survival rates were calculated by race, ag...

Detection of Extramedullary Multiple Myeloma in Liver by FDG-PET/CT

International Nuclear Information System (INIS)

Kim, Daeweung; Kim, Woo Hyoung; Kim, Myoung Hyoun; Choi, Keum Ha; Kim, Chang Guhn

2014-01-01

We present the case of a 42-year-old man with a painful mass lesion in the right shoulder that was detected by contrast-enhanced computed tomography (CT) and 18 F-fluoro-2-deoxyglucose ( 18 F-FDG) positron emission tomography (PET)/CT. Excisional biopsy revealed infiltration of plasma cells with anaplastic features, consistent with solitary plasmacytoma (PC). Serum analysis showed elevation of serum free lambda light chain levels (27.78 mg/l), with an abnormally high kappa:lambda ratio (2.33) and high total proteins (10.4 g/dl). Serum protein electrophoresis revealed an M spike in the gamma-globulin region (56.1 %=5.8 g/dl). Subsequently, 18 F-FDG PET/CT revealed another hypermetabolic mass in the right lobe of the liver. CT-guided biopsy of the liver lesion revealed plasma cell myeloma, consistent with multiple myeloma. Multiple myeloma presenting as nodular liver masses is very rare in clinical practice. In a retrospective review of more than 2,000 patients, Talamo et al. reported only nine cases where there was nodular involvement of the liver by multiple myeloma. The organ most commonly involved was the liver, followed by pancreas, stomach, peritoneum with malignant ascites, colon, rectum, duodenum and ileum. Therefore, the literature published thus far has been limited to a few reports and case series. Among these reports, some had demonstrated the PET or PET/CT findings of nodular liver involvement of multiple myeloma. About 10 % of the solitary myelomas appeared as extramedullary PC or solitary PC of bone. In spite of the advances in therapy, the treatment of multiple myeloma is still palliative. However, solitary PC could be cured by resection or radiation therapy. Thus, differentiation between PC and multiple myeloma is essential in making a decision for the appropriate therapeutic regimen. 18 F-FDG PET/CT has the unique ability to detect and characterize malignant lesions in one single examination. Schirrmeister et al. reported that 18 F-FDG PET revealed

Work Programme 2010. Nordic Energy Regulators (NordREG)

Energy Technology Data Exchange (ETDEWEB)

2010-02-15

The Nordic regulators' cooperation through NordREG is based on a strong consensus and common understanding of the Nordic market. Through mutual efforts and contributions NordREG members identify areas of work that can create added value for the Nordic electricity market. NordREG works by exchanging information and views, mapping and analysing energy market issues and by delivering statements and reports for harmonisation and improvement. In this, the regulators aim at identifying areas where NordREG can take joint action to influence Nordic or European electricity market development. NordREGs key focus in 2010 is the work towards a common Nordic retail market and the emphasis is on promoting a legal and institutional framework that supports this goal

Destabilization of Akt Promotes the Death of Myeloma Cell Lines

Directory of Open Access Journals (Sweden)

Yanan Zhang

2014-01-01

Full Text Available Constitutive activation of Akt is believed to be an oncogenic signal in multiple myeloma and is associated with poor patient prognosis and resistance to available treatment. The stability of Akt proteins is regulated by phosphorylating the highly conserved turn motif (TM of these proteins and the chaperone protein HSP90. In this study we investigate the antitumor effects of inhibiting mTORC2 plus HSP90 in myeloma cell lines. We show that chronic exposure of cells to rapamycin can inhibit mTORC2 pathway, and AKT will be destabilized by administration of the HSP90 inhibitor 17-allylamino-geldanamycin (17-AAG. Finally, we show that the rapamycin synergizes with 17-AAG and inhibits myeloma cells growth and promotes cell death to a greater extent than either drug alone. Our studies provide a clinical rationale of use mTOR inhibitors and chaperone protein inhibitors in combination regimens for the treatment of human blood cancers.

Energy research projects in the Nordic countries - catalogue 1983

International Nuclear Information System (INIS)

1983-01-01

The Nordic energy ministers at their meeting February 9, 1982 agreed upon a working plan for the Nordic energy cooperation. As part of this plan a contact group was established in order to maintain coordination and cooperation within the area of energy research and development. This group decided April 1982 to establish a catalogue of energy research projects in the Nordic countries. A pilot catalogue was published in June 1982. The 1983 catalogue gives an up-to-date survey of energy research and development projects in the Nordic countries. About 2125 projects are described, and information is given on investigator(s), performing organization, financing body, funds, and period. The catalogue is prepared by the Nordic energy libraries through their cooperation in Nordic Atomic Libraries Joint Secretariat. The information is also included in the data base Nordic Energy Index (NEI), which is online accessible at I/S Datacentralen, Copenhagen, via EURONET, SCANNET, TYMNET, AND TELENET. (BP)

Immunogenic Targets for Specific Immunotherapy in Multiple Myeloma

Directory of Open Access Journals (Sweden)

Lu Zhang

2012-01-01

Full Text Available Multiple myeloma remains an incurable disease although the prognosis has been improved by novel therapeutics and agents recently. Relapse occurs in the majority of patients and becomes fatal finally. Immunotherapy might be a powerful intervention to maintain a long-lasting control of minimal residual disease or to even eradicate disseminated tumor cells. Several tumor-associated antigens have been identified in patients with multiple myeloma. These antigens are expressed in a tumor-specific or tumor-restricted pattern, are able to elicit immune response, and thus could serve as targets for immunotherapy. This review discusses immunogenic antigens with therapeutic potential for multiple myeloma.

Hepatoblastoma in the nordic countries

DEFF Research Database (Denmark)

de Fine Licht, S; Schmidt, L S; Rod, Naja Hulvej

2011-01-01

Little is known about the aetiology of hepatoblastoma. Because of the young age at diagnosis, several studies have looked at various birth characteristics. The purpose of this study was to investigate the incidence of hepatoblastoma in the Nordic countries and the association between selected bir...

Palliative radiation therapy for multiple myeloma

International Nuclear Information System (INIS)

Minowa, Yasushi; Sasai, Keisuke; Ishigaki, Takashi; Nagata, Yasushi; Hiraoka, Masahiro

1996-01-01

Radiation therapy is a useful palliative modality for refractory lesions of multiple myeloma. It has been reported that total doses of 10 to 20 Gy are usually adequate to obtain some degree of pain relief. However, there are many patients who need additional doses to obtain sufficient pain relief. In this study. we retrospectively analyzed the records of patients with multiple myeloma irradiated at our department, in an attempt to develop an effective treatment policy for this disease. Twenty-nine patients with 53 lesions were treated between 1968 and 1993. Total irradiation doses were 4 to 60 Gy (median 40 Gy) with daily fractions of 2 Gy or less, and 16 to 51 Gy (median 30 Gy) with daily fractions greater than 2 Gy. Evaluated were 59 symptoms, including pain (68%), neurological abnormalities (15%), and masses (28%). Symptomatic remission was obtained in 33 of 36 (92%) lesions with pain, 6 of 8 (75%) with neurological abnormalities, and 13 of 15 (87%) mass lesions. Pain was partially relieved at a median TDF of 34, and completely at a median TDF of 66 (equivalent to 40-42 Gy with daily fractions of 2 Gy). Radiation therapy is an effective and palliative treatment method for symptomatic multiple myeloma. However, the treatment seems to require higher radiation doses than those reported to obtain adequate relief of symptoms. (author)

Shortcuts to sustainable Nordic communities. Experiences from Nordic Climate Festival (at) Aalto

Energy Technology Data Exchange (ETDEWEB)

Haanpaa, S [ed.

2011-07-01

Nordic Climate Festival (at) Aalto gathered some 90 Nordic Master's and PhD students to Helsinki and Espoo in late August 2011, to search for shortcuts to sustainable Nordic societies. The students worked in 7 workshop tracks, covering all key fields of sustainable societies, under the guidance of researchers from Aalto University. The workshop turned out to be a success with enthusiastic contribution from dedicated students. The real value of the workshop lies not only in the results however, but also in new ways of thinking about sustainability - both for the students and Aalto staff. Most of all, the event helped to build individual connections and networks people engaged in the topic. In the end, the festival was much more than just a Nordic event; the participants represented over 30 countries in total. This can only be seen as a richness in ways of looking at climate change related challenges and especially solutions that, although always being operationalized on a local level and in a local context, in the end are common challenges to all countries in one form or another. The core challenge in dealing with climate change, especially on mitigation, is time. As the level of global greenhouse gas emissions keeps on growing, we desperately need new policies and practices to turn this trend around. At the same time inertia both in natural phenomena and in changing our lifestyles means that global temperatures based on current emissions only will keep on rising for decades to come. This forces us to think of ways to adapt to unavoidable consequences of climate change and adaptation to them, despite the success of mitigation policies. Both aspects of managing climate change require forward oriented thinking already today, so that we can avoid being locked into unsustainable development pathways at the very least - a thing one might argue in many cases is already slowing mitigation efforts down. Therefore the key question the workshop set to study was: can we find

Interpreting values in the daily practices of Nordic preschools

DEFF Research Database (Denmark)

Broström, Stig; Anna-Maija, Puriola; Johannesson, Eva Marianne

2016-01-01

Abstract This study explored how practitioners interpreted educational practices from the perspective of values in Nordic preschools. Drawing data from group interviews in five Nordic countries (Denmark, Finland, Iceland, Norway and Sweden), practitioners reflected on an observational episode about...... children dressing for outdoor play in a Swedish preschool. The research material consisted of extracts from group interviews in ten preschools (two from each Nordic country). The research questions included: How do values emerge in practitioners’ interpretations? What is the interpretive process like...... and the co-construction of interpretations in the group dialogues. The practitioners employed indirect means more often than direct means to express their values. The group interviews contained themes that were connected to caring, disciplinary, competence and democratic values. The study provided evidence...

Nordic eHealth Indicators

DEFF Research Database (Denmark)

Hyppönen, Hannele; Faxvaag, Arild; Gilstad, Heidi

This report describes first results of the Network: eHealth policy analysis and first common Nordic eHealth indicators. The results show similarities and also some differences in the eHealth policies, priorities and implementation. Interesting similarities and differences in availability and use...... of eHealth services in the Nordic countries were found with the first comparable eHealth indicators. The results create a basis for Evidence-based policy making as well as benchmarking and learning best practices from each other....

Mania in the Nordic countries: patients and treatment in the acute phase of the EMBLEM study

DEFF Research Database (Denmark)

Larsen, Jens Knud; Porsdal, Vibeke; Aarre, Trond F

2009-01-01

countries with other European countries during the first 12 weeks of the EMBLEM (European Mania in Bipolar Longitudinal Evaluation of Medication) study. Adult patients with bipolar disorder were enrolled within standard course of care as in/outpatients if they initiated/changed oral medication...... status, functional status and pharmacological treatment. Psychiatric status at inclusion measured by the Young Mania Rating Scale (YMRS) and the Clinical Global Impression-Bipolar Disorder (CGI-BP) were similar in the Nordic and European patient groups, which is surprising as 73% of the Nordic patients...

Guidelines for supportive care in multiple myeloma 2011.

Science.gov (United States)

Snowden, John A; Ahmedzai, Sam H; Ashcroft, John; D'Sa, Shirley; Littlewood, Timothy; Low, Eric; Lucraft, Helen; Maclean, Rhona; Feyler, Sylvia; Pratt, Guy; Bird, Jennifer M

2011-07-01

Supportive care plays an increasingly important role in the modern management of multiple myeloma. While modern treatments have significantly prolonged overall and progression free survival through improved disease control, the vast majority of patients remain incurable, and live with the burden of the disease itself and the cumulative side effects of treatments. Maintenance of quality of life presents challenges at all stages of the disease from diagnosis through the multiple phases of active treatment to the end of life. Written on behalf of the British Committee for Standards in Haematology (BCSH) and the UK Myeloma Forum (UKMF), these evidence based guidelines summarize the current national consensus for supportive and symptomatic care in multiple myeloma in the following areas; pain management, peripheral neuropathy, skeletal complications, infection, anaemia, haemostasis and thrombosis, sedation, fatigue, nausea, vomiting, anorexia, constipation, diarrhoea, mucositis, bisphosphonate-induced osteonecrosis of the jaw, complementary therapies, holistic needs assessment and end of life care. Although most aspects of supportive care can be supervised by haematology teams primarily responsible for patients with multiple myeloma, multidisciplinary collaboration involving specialists in palliative medicine, pain management, radiotherapy and surgical specialities is essential, and guidance is provided for appropriate interdisciplinary referral. These guidelines should be read in conjunction with the BCSH/UKMF Guidelines for the Diagnosis and Management of Multiple Myeloma 2011. © 2011 Blackwell Publishing Ltd.

Proceedings of the joint Nordic spring meeting '92

International Nuclear Information System (INIS)

Lindgaard, P.-A.

1992-05-01

Proceedings in the form of extended abstracts of the Joint Nordic Spring Meeting '92 including the 3rd Nordic Conference on Surface Science, the 6th Nordic Symposium on Computer Simulation, and 3rd Nordic Symposium on Superconductivity. In addition there are contributions from workshops on the Physics of Small Cluster, on Soft Condensed Matter Physics and from an Electronic Properties Workshop. The proceedings constrain over 300 contributions on the mentioned subjects. Further, there are several contributions on general solid state subjects, magnetism, semiconductors etc. (au) (4 tabs., 187 ills., 931 refs.)

A Pictorial Review on Extraosseous Manifestations of Multiple Myelomas

International Nuclear Information System (INIS)

Seo, Jung Min; Lee, Kyung Soo; Yi, Chin A; Kim, Seong Hyun; Park, Byung Kwan; Han, Boo Kyung; Kim, Hyung Jin

2011-01-01

Extraosseous involvement of multiple myelomas can be seen clinically or radiologically in approximately 10-20% of patients at the time of initial diagnosis and may develop in an additional 15% of patients over the course of the disease. The condition can arise in any tissue of the body and its presence has been associated with more aggressive disease, a guarded prognosis, or high-dose chemotherapy. Imaging findings of extraosseous multiple myelomas are diverse. They usually show high enhancement on contrast-medium enhanced CT scans, exhibit iso-signal intensity on both T1- and T2- weighted images, and variable 18F-fluorine deoxyglucose (FDG) uptake at PET. The disease may simulate an infectious condition since it may be concurrent with underlying multiple myelomas per se or it may occur during myeloma treatment including stem cell transplantation.

Maxillary Swelling as the First Evidence of Multiple Myeloma

Directory of Open Access Journals (Sweden)

Atsushi Kasamatsu

2015-01-01

Full Text Available Multiple myeloma is a malignant neoplasm of plasma cells characterized by proliferation of a single clone of abnormal immunoglobulin-secreting plasma cells. Since the amount of hemopoietic bone marrow is decreased in the maxilla, oral manifestations of multiple myeloma are less common in the maxilla than in the mandible. We report the case of 33-year-old Japanese man who presented with a mass in the right maxillary alveolar region. Computed tomography and magnetic resonance images showed a soft tissue mass in the right maxilla eroding the anterior and lateral walls of the maxillary sinus and extending into the buccal space. The biopsy results, imaging, and laboratory investigations led to the diagnosis of multiple myeloma. This case report suggests that oral surgeons and dentists should properly address oral manifestations as first indications of multiple myeloma.

Maxillary Swelling as the First Evidence of Multiple Myeloma

Science.gov (United States)

Kasamatsu, Atsushi; Kimura, Yasushi; Tsujimura, Hideki; Kanazawa, Harusachi; Koide, Nao; Miyamoto, Isao; Endo-Sakamoto, Yosuke; Shiiba, Masashi; Tanzawa, Hideki; Uzawa, Katsuhiro

2015-01-01

Multiple myeloma is a malignant neoplasm of plasma cells characterized by proliferation of a single clone of abnormal immunoglobulin-secreting plasma cells. Since the amount of hemopoietic bone marrow is decreased in the maxilla, oral manifestations of multiple myeloma are less common in the maxilla than in the mandible. We report the case of 33-year-old Japanese man who presented with a mass in the right maxillary alveolar region. Computed tomography and magnetic resonance images showed a soft tissue mass in the right maxilla eroding the anterior and lateral walls of the maxillary sinus and extending into the buccal space. The biopsy results, imaging, and laboratory investigations led to the diagnosis of multiple myeloma. This case report suggests that oral surgeons and dentists should properly address oral manifestations as first indications of multiple myeloma. PMID:26640721

Predictors for readmission risk of new patients : the Nordic Comparative Study on Sectorized Psychiatry

NARCIS (Netherlands)

Oiesvold, T; Saarento, O; Sytema, S; Vinding, H; Gostas, G; Lonnerberg, O; Muus, S; Sandlund, M; Hansson, L

Objective: Predictors for readmission risk were investigated in this study, which forms part of the Nordic Comparative Study on Sectorized Psychiatry. Method: Included were a total of 837 consecutive 'new' patients (not in contact with the psychiatric services for at least 18 months) admitted to

Implementation of lung cancer CT screening in the Nordic countries

DEFF Research Database (Denmark)

Pedersen, Jesper Holst; Sørensen, Jens Benn; Saghir, Zaigham

2017-01-01

INTRODUCTION: We review the current knowledge of CT screening for lung cancer and present an expert-based, joint protocol for the proper implementation of screening in the Nordic countries. MATERIALS AND METHODS: Experts representing all the Nordic countries performed literature review...... and concensus for a joint protocol for lung cancer screening. RESULTS AND DISCUSSION: Areas of concern and caution are presented and discussed. We suggest to perform CT screening pilot studies in the Nordic countries in order to gain experience and develop specific and safe protocols for the implementation...

A school and inquiry based project with Nordic student teachers

DEFF Research Database (Denmark)

Stougaard, Birgitte

Álka is a framework involving teacher education institutions in the Nordic counties. This study describes the design of a module aiming at the establishment of a stronger nexus between research (theory) and teaching of science (practice) and to explore an issue relevant for the student teachers...... future professional life. The theme that was used for the research based project was: Nordic Children’s ideas about living things in the sea. Oral presentation at The 10th Nordic Research Symposium on Science Education (NFSUN), Linköbing, Sweden, June 2011....

Nordic research in logistics and supply chain management

DEFF Research Database (Denmark)

Arlbjørn, Jan Stentoft; Jonsson, Patrik; Johansen, John

2006-01-01

management and to explain how the discipline differs in terms of demographics, research areas, methodological approach, resources and publication. The analysis is conducted in a Nordic research context through a survey distributed to persons with research interest in logistics and supply chain management......This article reflects on research completed within logistics and supply chain management in the Nordic countries based on an empirical analysis. The purpose of this paper is to describe the characteristics of the Nordic academic discipline working in the field of logistics and supply chain....... The research does not provide clear empirical evidence of the contours of a Nordic research paradigm within logistics and supply chain management. The analysis shows that the significant and typical research issues among the Nordic researchers are the focus on supply chains/networks as the most important...

Occupation, exposure to chemicals, sensitizing agents, and risk of multiple myeloma in Sweden.

Science.gov (United States)

Lope, Virginia; Pérez-Gómez, Beatriz; Aragonés, Nuria; López-Abente, Gonzalo; Gustavsson, Per; Plato, Nils; Zock, Jan-Paul; Pollán, Marina

2008-11-01

This study sought to identify occupations with high incidence of multiple myeloma and to investigate possible excess risk associated with occupational exposure to chemicals and sensitizing agents in Sweden. A historical cohort of 2,992,166 workers was followed up (1971--1989) through record linkage with the National Cancer and Death Registries. For each job category, age and period standardized incidence ratios and age and period adjusted relative risks of multiple myeloma were calculated using Poisson models. Exposure to chemicals and to sensitizing agents was also assessed using two job-exposure matrices. Men and women were analyzed separately. During follow-up, 3,127 and 1,282 myelomas were diagnosed in men and women, respectively. In men, excess risk was detected among working proprietors, agricultural, horticultural and forestry enterprisers, bakers and pastry cooks, dental technicians, stone cutters/carvers, and prison/reformatory officials. In women, this excess was observed among attendants in psychiatric care, metal workers, bakers and pastry cooks, and paper/paperboard product workers. Workers, particularly bakers and pastry cooks, exposed to high molecular weight sensitizing agents registered an excess risk of over 40% across the sexes. Occasional, although intense, exposure to pesticides was also associated with risk of myeloma in our cohort. Our study supports a possible etiologic role for farming and use of pesticides in myeloma risk. The high incidence found in both female and male bakers and pastry cooks has not been described previously. Further research is required to assess the influence of high molecular weight sensitizing agents on risk of multiple myeloma.

CISG Part II in Nordic Context

DEFF Research Database (Denmark)

Lookofsky, Joseph

2015-01-01

In 2015, as the Nordic countries celebrate the 100th anniversary of the Nordic Contract Act (NCA), there is also good reason to celebrate the fact that - due to recent developments - the original field of NCA application has been narrowed in one important respect. In particular, the contract...... formation rules in NCA Chapter I – which for nearly 100 years applied by default to all contracts – no longer apply to contracts for the international sale of goods. As regards this latter significant contract category, Chapter I of the NCA has (except for inter-Nordic sales) been pre-empted, i.e. replaced...

MYC protein expression is detected in plasma cell myeloma but not in monoclonal gammopathy of undetermined significance (MGUS).

Science.gov (United States)

Xiao, Ruobing; Cerny, Jan; Devitt, Katherine; Dresser, Karen; Nath, Rajneesh; Ramanathan, Muthalagu; Rodig, Scott J; Chen, Benjamin J; Woda, Bruce A; Yu, Hongbo

2014-06-01

It has been recognized that monoclonal gammopathy of undetermined significance (MGUS) precedes a diagnosis of plasma cell myeloma in most patients. Recent gene expression array analysis has revealed that an MYC activation signature is detected in plasma cell myeloma but not in MGUS. In this study, we performed immunohistochemical studies using membrane CD138 and nuclear MYC double staining on bone marrow biopsies from patients who met the diagnostic criteria of plasma cell myeloma or MGUS. Our study demonstrated nuclear MYC expression in CD138-positive plasma cells in 22 of 26 (84%) plasma cell myeloma samples and in none of the 29 bone marrow samples from patients with MGUS. In addition, our data on the follow-up biopsies from plasma cell myeloma patients with high MYC expression demonstrated that evaluation of MYC expression in plasma cells can be useful in detecting residual disease. We also demonstrated that plasma cells gained MYC expression in 5 of 8 patients (62.5%) when progressing from MGUS to plasma cell myeloma. Analysis of additional lymphomas with plasmacytic differentiation, including lymphoplasmacytic lymphoma, marginal zone lymphoma, and plasmablastic lymphoma, reveals that MYC detection can be a useful tool in the diagnosis of plasma cell myeloma.

The modernisation of Nordic eating

DEFF Research Database (Denmark)

Holm, Lotte; Ekström, Marianne Pipping; Gronow, Jukka

2012-01-01

It is often claimed that in post-industrial societies eating is characterised by the dissolution of traditional cultural patterns regarding eating rhythms, the structure of meals and the social context of eating. This paper presents results from a Nordic quantitative and comparative study which...... was conducted in 1997 based on interviews with almost 5000 individuals from four nordic countries (Denmark, Finland, Norway and Sweden). The study showed that even through some flexibility was evident, eating was characterized by nationally different, but socially coordinated rhythms. Two distinct meal patterns...... were identified, a "western" pattern with one daily hot meal (Denmark, Norway), and an "eastern" patterns with two, daily hot meals (Finalnad, Sweden). Even though a lot of eating took place in solitude, eating was most often a social activity. It is concluded that daily eating patterns are still...

The Thrill of the Nordic Kill:The Manhunt Movie in the Nordic Thriller

OpenAIRE

Schubart, Rikke

2015-01-01

chapter in Nordic Genre Film: Small Nation Film Cultures in the Global Marketplace, eds Tommy Gustafsson and Pietari Kääpä. The chapter has three aims: First, it establishes the central generic traits of themanhunt movie. Second, it sets up a theoretical framework of sociobiological andecological theories with hunting as a reference point. And, third, it examines theNordic version of the manhunt movie focusing on the themes of hunting, nature,social standing, and civilization. I look at the D...

Parents' labour market participation as a predictor of children's health and wellbeing: a comparative study in five Nordic countries

DEFF Research Database (Denmark)

Reinhardt Pedersen, C; Madsen, Mette

2002-01-01

OBJECTIVE: To study the association between parents' labour market participation and children's health and wellbeing. DESIGN: Parent reported data on health and wellbeing among their children from the survey Health and welfare among children and adolescents in the Nordic countries, 1996. A cross...... significant. Health outcomes and parents' labour market participation were associated in all five countries. CONCLUSIONS: Children in families with no parents employed in the past six months had higher prevalence of ill health and low wellbeing in the five Nordic countries despite differences in employment...... sectional study of random samples of children and their families in five Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden). PARTICIPANTS: A total of 10 317 children aged 2-17 years. RESULTS: Children in families with no parents employed in the past six months had higher prevalence...

Time for a Nordic Business History Initiative?

DEFF Research Database (Denmark)

Ekberg, Espen; Iversen, Martin Jes

2018-01-01

The current state of Nordic business history is by certain estimates better than ever. Nordic business historians publish extensively in leading international journals and have a strong presence at international business history conferences. Still, in this discussion article we raise a yellow flag...... of warning for the future of Nordic business history. We argue that the subject field is challenged along three important dimensions: (i) lack of relevant teaching, (ii) continued reliance on commissioned history and (iii) limited recruitment. The article discusses these challenges and seeks to place them...... grounds for the development of such projects, The Scandinavian Society for Economic and Social History – the formal collaborative body for Nordic economic historians and the owner of Scandinavian Economic History Review – should be reinvigorated....

Changing health inequalities in the Nordic countries?

Science.gov (United States)

Lahelma, E; Lundberg, O; Manderbacka, K; Roos, E

2001-01-01

The Nordic countries, referring here to Denmark, Finland, Norway, and Sweden, have often been viewed as a group of countries with many features in common, such as geographical location, history, culture, religion, language, and economic and political structures. It has also been habitual to refer to a "Nordic model" of welfare states comprising a large public sector, active labour market policies, high costs for social welfare as well as high taxes, and a general commitment to social equality. Recent research suggests that much of this "Nordicness" appears to remain despite the fact that the Nordic countries have experienced quite different changes during the 1980s and 1990s. How this relates to changes in health inequalities is in the focus of this supplement.

Avoidable cancers in the Nordic countries. Radiation

DEFF Research Database (Denmark)

Winther, J F; Ulbak, Kaare; Dreyer, L

1997-01-01

Exposure to solar and ionizing radiation increases the risk for cancer in humans. Some 5% of solar radiation is within the ultraviolet spectrum and may cause both malignant melanoma and non-melanocytic skin cancer; the latter is regarded as a benign disease and is accordingly not included in our...... malignant melanomas arising in the Nordic populations around the year 2000 will be due to exposure to natural ultraviolet radiation, equivalent to an annual number of about 4700 cases, with 2100 in men and 2600 in women, or some 4% of all cancers notified. Exposure to ionizing radiation in the Nordic...... and building materials, the man-made sources are dominated by the diagnostic and therapeutic use of ionizing radiation. On the basis of measured levels of radon in Nordic dwellings and associated risk estimates for lung cancer derived from well-conducted epidemiological studies, we estimated that about 180...

Drug response prediction in high-risk multiple myeloma

DEFF Research Database (Denmark)

Vangsted, A J; Helm-Petersen, S; Cowland, J B

2018-01-01

from high-risk patients by GEP70 at diagnosis from Total Therapy 2 and 3A to predict the response by the DRP score of drugs used in the treatment of myeloma patients. The DRP score stratified patients further. High-risk myeloma with a predicted sensitivity to melphalan by the DRP score had a prolonged...

Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma.

Science.gov (United States)

Chinen, Yoshiaki; Kuroda, Junya; Shimura, Yuji; Nagoshi, Hisao; Kiyota, Miki; Yamamoto-Sugitani, Mio; Mizutani, Shinsuke; Sakamoto, Natsumi; Ri, Masaki; Kawata, Eri; Kobayashi, Tsutomu; Matsumoto, Yosuke; Horiike, Shigeo; Iida, Shinsuke; Taniwaki, Masafumi

2014-12-15

Multiple myeloma is a cytogenetically/molecularly heterogeneous hematologic malignancy that remains mostly incurable, and the identification of a universal and relevant therapeutic target molecule is essential for the further development of therapeutic strategy. Herein, we identified that 3-phosphoinositide-dependent protein kinase 1 (PDPK1), a serine threonine kinase, is expressed and active in all eleven multiple myeloma-derived cell lines examined regardless of the type of cytogenetic abnormality, the mutation state of RAS and FGFR3 genes, or the activation state of ERK and AKT. Our results revealed that PDPK1 is a pivotal regulator of molecules that are essential for myelomagenesis, such as RSK2, AKT, c-MYC, IRF4, or cyclin Ds, and that PDPK1 inhibition caused the growth inhibition and the induction of apoptosis with the activation of BIM and BAD, and augmented the in vitro cytotoxic effects of antimyeloma agents in myeloma cells. In the clinical setting, PDPK1 was active in myeloma cells of approximately 90% of symptomatic patients at diagnosis, and the smaller population of patients with multiple myeloma exhibiting myeloma cells without active PDPK1 showed a significantly less frequent proportion of the disease stage III by the International Staging System and a significantly more favorable prognosis, including the longer overall survival period and the longer progression-free survival period by bortezomib treatment, than patients with active PDPK1, suggesting that PDPK1 activation accelerates the disease progression and the resistance to treatment in multiple myeloma. Our study demonstrates that PDPK1 is a potent and a universally targetable signaling mediator in multiple myeloma regardless of the types of cytogenetic/molecular profiles. ©2014 American Association for Cancer Research.

Pleural Effusion in Multiple Myeloma.

Science.gov (United States)

Wang, Zhuo; Xia, Guoguang; Lan, Ling; Liu, Fayong; Wang, Yanxun; Liu, Baoyue; Ding, Yi; Dai, Li; Zhang, Yunjian

2016-01-01

Pleural effusion is rarely observed in patients with multiple myeloma (MM). Myeloma cell infiltration or invasion to the pleura is very rare. This study aimed to investigate the clinical characteristics of pleural effusion in patients with MM. We retrospectively reviewed the medical records of patients diagnosed with pleural effusion, MM, and pleural effusion with MM between 2004 and 2014 at Beijing Jishuitan Hospital. The present study included patients with pleural effusion who underwent cytological, bacteriological, biochemical and other testing. The cytopathology of abnormal pleural effusion cells was not diagnostic, thus flow cytometry was performed. MM was defined using the diagnosis standard of NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) 2014 for MM. This study included 3,480 pleural effusion patients and 319 MM patients. There were 34 patients with both MM and pleural effusion (17 men and 17 women). The average age was 63 years (range, 48-84 years). Pleural effusion with MM was caused by congestive heart disease, chronic renal failure, hypoalbuminemia, pulmonary infarctions, cirrhosis, pulmonary arterial hypertension, parapneumonic effusion, tuberculous pleural effusion, and myelomatous pleural effusion (MPE). The diagnosis of MPE was confirmed by the detection of myeloma cells in the pleural fluid using flow cytometric analyses. There were only 2 MPE cases in our study. The first MPE case was a woman. The first clinical manifestation was pleural effusion, and the diagnosis was non-secretory MM, DSS stage IIIA (Durie-Salmon staging system); ISS stage I (the International Staging System). The second MPE case was a man who was diagnosed with MM IgA-κ, DSS stage IIIA; ISS stage II. The detection rate of MPE was very low. MPE tended to present with yellow exudates and the lack of physical and chemical characteristics. Furthermore, patients with MPE exhibited many yellow nodules on the pleura. These nodules were lobulated and had abundant

New treatment strategies for multiple myeloma by targeting Bcl-2 and the mevalonate pathway

NARCIS (Netherlands)

Donk, N.W.C.J. van de

2003-01-01

Multiple myeloma is a B-lineage neoplasia. Enhanced proliferation and defects in the regulation of programmed cell death account for the expansion of the malignant clone. Emergence of drug resistance is the primary cause of treatment failure in myeloma. Various studies have indicated that inhibition

Biochemical markers of bone metabolism reflect osteoclastic and osteoblastic activity in multiple myeloma

DEFF Research Database (Denmark)

Abildgaard, N; Glerup, H; Rungby, Jørgen

2000-01-01

In order to evaluate the use of recently developed assays of bone metabolism in multiple myeloma we performed a histomorphometric study of bone biopsies in 16 myeloma patients. Furthermore, we measured the levels of interleukin-6 (IL-6), soluble IL-6 receptor (IL-6sR), IL-1beta, tumour necrosis f...

Ethical aspects of registry-based research in the Nordic countries.

Science.gov (United States)

Ludvigsson, Jonas F; Håberg, Siri E; Knudsen, Gun Peggy; Lafolie, Pierre; Zoega, Helga; Sarkkola, Catharina; von Kraemer, Stephanie; Weiderpass, Elisabete; Nørgaard, Mette

2015-01-01

National health care registries in the Nordic countries share many attributes, but different legal and ethical frameworks represent a challenge to promoting effective joint research. Internationally, there is a lack of knowledge about how ethical matters are considered in Nordic registry-based research, and a lack of knowledge about how Nordic ethics committees operate and what is needed to obtain an approval. In this paper, we review ethical aspects of registry-based research, the legal framework, the role of ethics review boards in the Nordic countries, and the structure of the ethics application. We discuss the role of informed consent in registry-based research and how to safeguard the integrity of study participants, including vulnerable subjects and children. Our review also provides information on the different government agencies that contribute registry-based data, and a list of the major health registries in Denmark, Finland, Iceland, Norway, and Sweden. Both ethical values and conditions for registry-based research are similar in the Nordic countries. While Denmark, Finland, Iceland, Norway, and Sweden have chosen different legal frameworks, these differences can be resolved through mutual recognition of ethical applications and by harmonizing the different systems, likely leading to increased collaboration and enlarged studies.

Detection of Extramedullary Multiple Myeloma in Liver by FDG-PET/CT

Energy Technology Data Exchange (ETDEWEB)

Kim, Daeweung; Kim, Woo Hyoung; Kim, Myoung Hyoun; Choi, Keum Ha; Kim, Chang Guhn [Wonkwang Univ. School of Medicine, Iksan (Korea, Republic of)

2014-06-15

We present the case of a 42-year-old man with a painful mass lesion in the right shoulder that was detected by contrast-enhanced computed tomography (CT) and {sup 18}F-fluoro-2-deoxyglucose ({sup 18}F-FDG) positron emission tomography (PET)/CT. Excisional biopsy revealed infiltration of plasma cells with anaplastic features, consistent with solitary plasmacytoma (PC). Serum analysis showed elevation of serum free lambda light chain levels (27.78 mg/l), with an abnormally high kappa:lambda ratio (2.33) and high total proteins (10.4 g/dl). Serum protein electrophoresis revealed an M spike in the gamma-globulin region (56.1 %=5.8 g/dl). Subsequently, {sup 18}F-FDG PET/CT revealed another hypermetabolic mass in the right lobe of the liver. CT-guided biopsy of the liver lesion revealed plasma cell myeloma, consistent with multiple myeloma. Multiple myeloma presenting as nodular liver masses is very rare in clinical practice. In a retrospective review of more than 2,000 patients, Talamo et al. reported only nine cases where there was nodular involvement of the liver by multiple myeloma. The organ most commonly involved was the liver, followed by pancreas, stomach, peritoneum with malignant ascites, colon, rectum, duodenum and ileum. Therefore, the literature published thus far has been limited to a few reports and case series. Among these reports, some had demonstrated the PET or PET/CT findings of nodular liver involvement of multiple myeloma. About 10 % of the solitary myelomas appeared as extramedullary PC or solitary PC of bone. In spite of the advances in therapy, the treatment of multiple myeloma is still palliative. However, solitary PC could be cured by resection or radiation therapy. Thus, differentiation between PC and multiple myeloma is essential in making a decision for the appropriate therapeutic regimen. {sup 18}F-FDG PET/CT has the unique ability to detect and characterize malignant lesions in one single examination. Schirrmeister et al. reported that

Myeloma cells suppress osteoblasts through sclerostin secretion

Energy Technology Data Exchange (ETDEWEB)

Colucci, S; Brunetti, G; Oranger, A [Department of Human Anatomy and Histology, University of Bari Medical School, Bari (Italy); Mori, G [Department of Biomedical Science, University of Foggia, Foggia (Italy); Sardone, F [Department of Human Anatomy and Histology, University of Bari Medical School, Bari (Italy); Specchia, G; Rinaldi, E; Curci, P; Liso, V [Department of Emergency and Organ Transplantation, Hematology Section, Bari University Medical School, Bari (Italy); Passeri, G [Department of Internal Medicine and Biomedical Sciences, Center for Metabolic Bone Diseases, University of Parma, Parma (Italy); Zallone, A [Department of Human Anatomy and Histology, University of Bari Medical School, Bari (Italy); Rizzi, R [Department of Emergency and Organ Transplantation, Hematology Section, Bari University Medical School, Bari (Italy); Grano, M [Department of Human Anatomy and Histology, University of Bari Medical School, Bari (Italy)

2011-06-01

Wingless-type (Wnt) signaling through the secretion of Wnt inhibitors Dickkopf1, soluble frizzled-related protein-2 and -3 has a key role in the decreased osteoblast (OB) activity associated with multiple myeloma (MM) bone disease. We provide evidence that another Wnt antagonist, sclerostin, an osteocyte-expressed negative regulator of bone formation, is expressed by myeloma cells, that is, human myeloma cell lines (HMCLs) and plasma cells (CD138+ cells) obtained from the bone marrow (BM) of a large number of MM patients with bone disease. We demonstrated that BM stromal cells (BMSCs), differentiated into OBs and co-cultured with HMCLs showed, compared with BMSCs alone, reduced expression of major osteoblastic-specific proteins, decreased mineralized nodule formation and attenuated the expression of members of the activator protein 1 transcription factor family (Fra-1, Fra-2 and Jun-D). Moreover, in the same co-culture system, the addition of neutralizing anti-sclerostin antibodies restored OB functions by inducing nuclear accumulation of β-catenin. We further demonstrated that the upregulation of receptor activator of nuclear factor κ-B ligand and the downregulation of osteoprotegerin in OBs were also sclerostin mediated. Our data indicated that sclerostin secretion by myeloma cells contribute to the suppression of bone formation in the osteolytic bone disease associated to MM.

Shared and task-specific muscle synergies of Nordic walking and conventional walking.

Science.gov (United States)

Boccia, G; Zoppirolli, C; Bortolan, L; Schena, F; Pellegrini, B

2018-03-01

Nordic walking is a form of walking that includes a poling action, and therefore an additional subtask, with respect to conventional walking. The aim of this study was to assess whether Nordic walking required a task-specific muscle coordination with respect to conventional walking. We compared the electromyographic (EMG) activity of 15 upper- and lower-limb muscles of 9 Nordic walking instructors, while executing Nordic walking and conventional walking at 1.3 ms -1 on a treadmill. Non-negative matrix factorization method was applied to identify muscle synergies, representing the spatial and temporal organization of muscle coordination. The number of muscle synergies was not different between Nordic walking (5.2 ± 0.4) and conventional walking (5.0 ± 0.7, P = .423). Five muscle synergies accounted for 91.2 ± 1.1% and 92.9 ± 1.2% of total EMG variance in Nordic walking and conventional walking, respectively. Similarity and cross-reconstruction analyses showed that 4 muscle synergies, mainly involving lower-limb and trunk muscles, are shared between Nordic walking and conventional walking. One synergy acting during upper limb propulsion is specific to Nordic walking, modifying the spatial organization and the magnitude of activation of upper limb muscles compared to conventional walking. The inclusion of the poling action in Nordic walking does not increase the complexity of movement control and does not change the coordination of lower limb muscles. This makes Nordic walking a physical activity suitable also for people with low motor skill. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

An Overview of Nordic Contract Law

DEFF Research Database (Denmark)

Andersen, Mads Bryde; Runesson, Eric

2015-01-01

This essay is published as the opening chapter in a book that celebrates the 100 year anniversary of the uniform Nordic Contracts Acts. It introduces some of the main concepts, main rules and lines of argumentation that you will find in Nordic contract law. Thereby it introduces the reader...

Genetic variations in multiple myeloma I

DEFF Research Database (Denmark)

Vangsted, A.; Klausen, T.W.; Vogel, Ulla Birgitte

2012-01-01

Few risk factors have been established for the plasma cell disorder multiple myeloma, but some of these like African American ethnicity and a family history of B-cell lymphoproliferative diseases suggest a genetic component for the disease. Genetic variation represents the genetic basis of variab......Few risk factors have been established for the plasma cell disorder multiple myeloma, but some of these like African American ethnicity and a family history of B-cell lymphoproliferative diseases suggest a genetic component for the disease. Genetic variation represents the genetic basis...

Myelomatous ascites as an initial manifestation of extramedullary involvement of multiple myeloma

Energy Technology Data Exchange (ETDEWEB)

Choi, Seo Youn; Lee, Hae Kyung; Yi, Boem Ha; Lee, Min Hee; Kim, Hee Kyung; Park, Seong Kyu [Soonchunhyang University Bucheon Hospital, Bucheon (Korea, Republic of)

2017-03-15

Multiple myeloma is a common hematological malignancy. Aggressive myeloma invades the organs outside the bone marrow, lymph, or reticuloendothelial systems. Among the extramedullary involvements of multiple myeloma, myelomatous ascites are extremely rare and are associated with a poor prognosis. We describe a case of myelomatous ascites as an initial manifestation of extramedullary involvement of multiple myeloma in 39-year-old patient. The patient was treated with high-dose chemotherapy, but extensive extramedullary involvement progressed, and the patient expired approximately five months after the initial detection of ascites.

Enhancing efficient functioning of the nordic electricity market. Summary and conclusions

International Nuclear Information System (INIS)

2005-02-01

In September 2004, Nordic Council of Ministers (NCM) in their meeting in Akureyri, Iceland, assessed the state of the Nordic electricity market. The Ministers acknowledged that the market has proved it is well functioning in many respects, however, further development of the Nordic electricity market is needed, i.e. towards a regional market without borders. The Nordic Transmission System Operators (TSOs) were asked to study how a further co-ordination of the system responsibility, a joint organizing and financing of the grid investments and a handling of peak load situations can be established in the Nordic countries. In this report, the main focus is on market-related tasks within system responsibility that are market-related and may have an effect on the functioning of the market. The report covers the following issues: definition of the system responsibility and role of TSOs, harmonization of operational rules and practices in order to improve functioning of the market, TSOs' collaboration in disturbances and shortage situations and joint Nordic transmission investments. Furthermore, the report summarizes the concrete actions taken by the TSOs in strengthening of the market mechanisms in peak load situations. (BA)

Enhancing efficient functioning of the nordic electricity market. Summary and conclusions

Energy Technology Data Exchange (ETDEWEB)

NONE

2005-02-01

In September 2004, Nordic Council of Ministers (NCM) in their meeting in Akureyri, Iceland, assessed the state of the Nordic electricity market. The Ministers acknowledged that the market has proved it is well functioning in many respects, however, further development of the Nordic electricity market is needed, i.e. towards a regional market without borders. The Nordic Transmission System Operators (TSOs) were asked to study how a further co-ordination of the system responsibility, a joint organizing and financing of the grid investments and a handling of peak load situations can be established in the Nordic countries. In this report, the main focus is on market-related tasks within system responsibility that are market-related and may have an effect on the functioning of the market. The report covers the following issues: definition of the system responsibility and role of TSOs, harmonization of operational rules and practices in order to improve functioning of the market, TSOs' collaboration in disturbances and shortage situations and joint Nordic transmission investments. Furthermore, the report summarizes the concrete actions taken by the TSOs in strengthening of the market mechanisms in peak load situations. (BA)

Greening of Nordic electricity industry: policy convergence and diversity

International Nuclear Information System (INIS)

Midttun, Atle; Gundersen, Mari Hegg; Koefoed, Anne Louise

2004-01-01

With a comparative focus on policy similarity and diversity, this article gives an overview of the main elements of electricity-related environmental policy in the Nordic countries, following the launching of a common electricity market in the 1990s. The article points out that the electricity related environmental policy positions of the Nordic countries showed a noticeable lack of coordination in the 1990s. Nordic divergence is observed both in terms of general policy orientations and at the instrument and incentive levels, in spite of the pioneering development of a common integrated electricity market and ambitious environmental policy goals. The article then highlights how the recent Swedish 'green' certificate market model has created a new momentum for market-based 'greening' with a potential for stronger convergence in Nordic renewable energy policy. In spite of signs of convergence, the article shows how the development of Nordic electricity-related environmental policy still contains considerable ambiguity: Unequal resource endowments, subject to simple resource-based interest formation, should indicate that there is little room for convergence in Nordic renewable energy policy. Shifting the environmental policy focus from existing technologies and resources to potential innovations, however provides a more open arena where the Nordic countries may see themselves served by the dynamic scope of a broader Nordic market based on a common policy approach, such as a green certificate market. In explaining why the Nordic arena may be an interesting locus for common renewable energy policy, the article points out that small countries may need an 'intermediary' arena to aggregate size and scope in order to generate a European momentum in regulatory competition with larger European states. Similarly, Nordic companies may consider the opportunity to gain first mover advantages by partnering with government as local experimentation may be seen as useful pilot

Multiple myeloma and central nervous system involvement: experience of a Brazilian center

Directory of Open Access Journals (Sweden)

Ana Luiza Miranda Silva Dias

2018-01-01

Full Text Available Introduction: The estimated involvement of the central nervous system in patients with multiple myeloma is rare at about 1%. The infiltration can be identified at the time multiple myeloma is diagnosed or during its progression. However, it is more common in refractory disease or during relapse. Methods: This retrospective cohort study reviewed data from medical records of patients followed up at the Gammopathy Outpatient Clinic of Santa Casa de Misericórdia de São Paulo from January 2008 to December 2016. Results: Twenty patients were included, with a median follow-up of 33.5 months after central nervous system infiltration. The prevalence was 7%. The median age at diagnosis of multiple myeloma was 56.1 years, with 70% of participants being female. Sixteen patients had central nervous system infiltration at diagnosis of multiple myeloma. Seventeen patients had exclusive osteodural lesions and three had infiltrations of the leptomeninge, of which one had exclusive involvement and two had associated osteodural lesions. The median overall survival was 40.3 months after central nervous system involvement. The median overall survival in the group with central nervous system infiltration at relapse was 7.4 months. The patients with leptomeningeal involvement had a median overall survival of 5.8 months. Conclusion: Central nervous system infiltration is a rare condition, but it should be considered as a possibility in patients with multiple myeloma and neurological symptoms. The best treatment regimen for this condition remains unknown and, in most cases, the prognosis is unfavorable. Keywords: Central nervous system, Multiple myeloma, Radiotherapy, Chemotherapy, Prognosis

Nordic monitoring on diet, physical activity and overweight

DEFF Research Database (Denmark)

Fagt, Sisse; Andersen, Lene Frost; Anderssen, Sigmund A.

. In 2009, the indicator questions were validated against an objective method (physical activity) or existing survey methods (diet) and the present report mainly describes the validation studies. On basis of the validation studies the working group suggests that the indicators are used in a future......In 2007, a Nordic working group was established with the aim to describe a future Nordic monitoring system on diet, physical activity and overweight. The monitoring system should be simple and at relatively low cost. Therefore it has been decided to conduct the moni-toring as a telephone interview...

Inhibition of fatty acid metabolism reduces human myeloma cells proliferation.

Directory of Open Access Journals (Sweden)

José Manuel Tirado-Vélez

Full Text Available Multiple myeloma is a haematological malignancy characterized by the clonal proliferation of plasma cells. It has been proposed that targeting cancer cell metabolism would provide a new selective anticancer therapeutic strategy. In this work, we tested the hypothesis that inhibition of β-oxidation and de novo fatty acid synthesis would reduce cell proliferation in human myeloma cells. We evaluated the effect of etomoxir and orlistat on fatty acid metabolism, glucose metabolism, cell cycle distribution, proliferation, cell death and expression of G1/S phase regulatory proteins in myeloma cells. Etomoxir and orlistat inhibited β-oxidation and de novo fatty acid synthesis respectively in myeloma cells, without altering significantly glucose metabolism. These effects were associated with reduced cell viability and cell cycle arrest in G0/G1. Specifically, etomoxir and orlistat reduced by 40-70% myeloma cells proliferation. The combination of etomoxir and orlistat resulted in an additive inhibitory effect on cell proliferation. Orlistat induced apoptosis and sensitized RPMI-8226 cells to apoptosis induction by bortezomib, whereas apoptosis was not altered by etomoxir. Finally, the inhibitory effect of both drugs on cell proliferation was associated with reduced p21 protein levels and phosphorylation levels of retinoblastoma protein. In conclusion, inhibition of fatty acid metabolism represents a potential therapeutic approach to treat human multiple myeloma.

Fitness Club / Nordic Walking

CERN Multimedia

Fitness Club

2011-01-01

Nordic Walking at CERN Enrollments are open for Nordic Walking courses and outings at CERN. Classes will be on Tuesdays as of 20 September, and outings for the more experienced will be on Thursdays as of 15 September. We meet at the CERN Club barracks car park (near entrance A). • 18:00 to 19:00 on 20 & 27 September, as well as 4 & 11 October. Check out our schedule and rates and enroll at: http://cern.ch/club-fitness Hope to see you among us! CERN Fitness Club fitness.club@cern.ch  

Nordic Model of Subregional Co-Operation

Directory of Open Access Journals (Sweden)

Grzela Joanna

2017-12-01

Full Text Available Nordic co-operation is renowned throughout the world and perceived as the collaboration of a group of countries which are similar in their views and activities. The main pillars of the Nordic model of co-operation are the tradition of constitutional principles, activity of public movements and organisations, freedom of speech, equality, solidarity, and respect for the natural environment. In connection with labour and entrepreneurship, these elements are the features of a society which favours efficiency, a sense of security and balance between an individual and a group. Currently, the collaboration is a complex process, including many national, governmental and institutional connections which form the “Nordic family”.

The Heritability of Prostate Cancer in the Nordic Twin Study of Cancer

DEFF Research Database (Denmark)

Hjelmborg, Jacob B; Scheike, Thomas; Holst, Klaus

2014-01-01

Background: Prostate cancer is thought to be the most heritable cancer, although little is known about how this genetic contribution varies across age. Methods: To address this question, we undertook the world's largest prospective study in the Nordic Twin Study of Cancer cohort, including 18,680....... The role of genetic factors is consistently high across age Impact: Findings impact the search for genetic and epigenetic markers and frame prevention efforts....

Nordic Management and Sustainable Business

DEFF Research Database (Denmark)

Preuss, Bjørn

2017-01-01

The Nordics have been since a longer time a role model for a social and reliable management style. However, this statement was in the last just proven by doing few case studies with top executives. This study wants to describe the corporate culture and management style in the biggest companies...

Shortcuts to sustainable Nordic communities. Experiences from Nordic Climate Festival (at) Aalto

Energy Technology Data Exchange (ETDEWEB)

Haanpaa, S. (ed.)

2011-07-01

Nordic Climate Festival (at) Aalto gathered some 90 Nordic Master's and PhD students to Helsinki and Espoo in late August 2011, to search for shortcuts to sustainable Nordic societies. The students worked in 7 workshop tracks, covering all key fields of sustainable societies, under the guidance of researchers from Aalto University. The workshop turned out to be a success with enthusiastic contribution from dedicated students. The real value of the workshop lies not only in the results however, but also in new ways of thinking about sustainability - both for the students and Aalto staff. Most of all, the event helped to build individual connections and networks people engaged in the topic. In the end, the festival was much more than just a Nordic event; the participants represented over 30 countries in total. This can only be seen as a richness in ways of looking at climate change related challenges and especially solutions that, although always being operationalized on a local level and in a local context, in the end are common challenges to all countries in one form or another. The core challenge in dealing with climate change, especially on mitigation, is time. As the level of global greenhouse gas emissions keeps on growing, we desperately need new policies and practices to turn this trend around. At the same time inertia both in natural phenomena and in changing our lifestyles means that global temperatures based on current emissions only will keep on rising for decades to come. This forces us to think of ways to adapt to unavoidable consequences of climate change and adaptation to them, despite the success of mitigation policies. Both aspects of managing climate change require forward oriented thinking already today, so that we can avoid being locked into unsustainable development pathways at the very least - a thing one might argue in many cases is already slowing mitigation efforts down. Therefore the key question the workshop set to study was: can we

Continuous lenalidomide treatment for newly diagnosed multiple myeloma

DEFF Research Database (Denmark)

Palumbo, Antonio; Hajek, Roman; Delforge, Michel

2012-01-01

Lenalidomide has tumoricidal and immunomodulatory activity against multiple myeloma. This double-blind, multicenter, randomized study compared melphalan-prednisone-lenalidomide induction followed by lenalidomide maintenance (MPR-R) with melphalan-prednisone-lenalidomide (MPR) or melphalan-prednis...

A nordic charter for universal design.

Science.gov (United States)

Björk, Evastina

2014-02-01

The aim of this paper is to present the result of a pioneer project; A Nordic Charter for Universal Design, which was initiated by the Norwegian Directorate for Children, Youth and Family Affairs in 2011. The purpose of the Charter was to present rationales that stated prerequisites for successful investment in Universal Design, and to establish a platform for further research and good practice. It was also meant to contribute to spreading of information and knowledge about the importance of guidance by the concept of Universal Design of initiatives with effects on the public arena. A Nordic group of researchers and professionals in the field ended up after 8 months of work with a written document: "A Nordic Charter for Universal Design", which was presented at the International Conference in Universal Design in Oslo, Norway (UD 2012). A Nordic Charter for Universal Design. Persons with disabilities often experience the public arenas environments, products and services as poorly-designed to fit their abilities and/or their needs. Together with the demographic changes in the Nordic societies with an increasing number of elderly people, it needs initiatives to improve independence, accessibility and participation in society. A strategy which aims to make design and composition of different environments, products, communication, information technology and services accessible, usable and understandable to as many as possible is Universal Design.

Emergency peripartum hysterectomy: results from the prospective Nordic Obstetric Surveillance Study (NOSS).

Science.gov (United States)

Jakobsson, Maija; Tapper, Anna-Maija; Colmorn, Lotte Berdiin; Lindqvist, Pelle G; Klungsøyr, Kari; Krebs, Lone; Børdahl, Per E; Gottvall, Karin; Källén, Karin; Bjarnadóttir, Ragnheiður I; Langhoff-Roos, Jens; Gissler, Mika

2015-07-01

To assess the prevalence and risk factors of emergency peripartum hysterectomy. Nordic collaborative study. 605 362 deliveries across the five Nordic countries. We collected data prospectively from patients undergoing emergency peripartum hysterectomy within 7 days of delivery from medical birth registers and hospital discharge registers. Control populations consisted of all other women delivering on the same units during the same time period. Emergency peripartum hysterectomy rate. The total number of emergency peripartum hysterectomies reached 211, yielding an incidence rate of 3.5/10 000 (95% confidence interval 3.0-4.0) births. Finland had the highest prevalence (5.1) and Norway the lowest (2.9). Primary indications included an abnormally invasive placenta (n = 91, 43.1%), atonic bleeding (n = 69, 32.7%), uterine rupture (n = 31, 14.7%), other bleeding disorders (n = 12, 5.7%), and other indications (n = 8, 3.8%). The delivery mode was cesarean section in nearly 80% of cases. Previous cesarean section was reported in 45% of women. Both preterm and post-term birth increased the risk for emergency peripartum hysterectomy. The number of stillbirths was substantially high (70/1000), but the case fatality rate stood at 0.47% (one death, maternal mortality rate 0.17/100 000 deliveries). A combination of prospective data collected from clinicians and information gathered from register-based databases can yield valuable data, improving the registration accuracy for rare, near-miss cases. However, proper and uniform clinical guidelines for the use of well-defined international diagnostic codes are still needed. © 2015 Nordic Federation of Societies of Obstetrics and Gynecology.

Free light chains of immunoglobulins in the diagnosis and prognosis of multiple myeloma

Directory of Open Access Journals (Sweden)

N. V. Lyubimova

2017-01-01

determination, as well as to monitor patients with non-secreting multiple myeloma. FLC analysis in multiple myeloma patients acquires special significance in the prognosis of remission, since the antitumor response based on their measurement is seen earlier than that based on the results of standard immunochemistry studies.

Effects of Nordic walking and walking on spatiotemporal gait parameters and ground reaction force.

Science.gov (United States)

Park, Seung Kyu; Yang, Dae Jung; Kang, Yang Hun; Kim, Je Ho; Uhm, Yo Han; Lee, Yong Seon

2015-09-01

[Purpose] The purpose of this study was to investigate the effects of Nordic walking and walking on spatiotemporal gait parameters and ground reaction force. [Subjects] The subjects of this study were 30 young adult males, who were divided into a Nordic walking group of 15 subjects and a walking group of 15 subjects. [Methods] To analyze the spatiotemporal parameters and ground reaction force during walking in the two groups, the six-camera Vicon MX motion analysis system was used. The subjects were asked to walk 12 meters using the more comfortable walking method for them between Nordic walking and walking. After they walked 12 meters more than 10 times, their most natural walking patterns were chosen three times and analyzed. To determine the pole for Nordic walking, each subject's height was multiplied by 0.68. We then measured the spatiotemporal gait parameters and ground reaction force. [Results] Compared with the walking group, the Nordic walking group showed an increase in cadence, stride length, and step length, and a decrease in stride time, step time, and vertical ground reaction force. [Conclusion] The results of this study indicate that Nordic walking increases the stride and can be considered as helping patients with diseases affecting their gait. This demonstrates that Nordic walking is more effective in improving functional capabilities by promoting effective energy use and reducing the lower limb load, because the weight of the upper and lower limbs is dispersed during Nordic walking.

Radiation Protection Legislation in the Nordic Countries

International Nuclear Information System (INIS)

Person, Lars.

1990-01-01

Recent alterations in the radiation protection laws of the Nordic countries are presented. The report amends the previous SS-report 87-37 with the title Radiation Protection and Atomic Energy Legislation in the Nordic Countries. (au)

Multiple myeloma associated with acquired cutis laxa.

Science.gov (United States)

Cho, S Y; Maguire, R F

1980-08-01

Acquired cutis laxa is a rare disorder characterized by diffuse laxity of the skin and loss of connective tissue support with involvement of the lungs, gastrointestinal tract, pelvic organs, and aorta. The case report presented herein describes a forty-six year old woman with multiple myeloma and cutis laxa. Her history included several severe allergic reactions and the gradual development of lax skin, loss of connective tissue support throughout the body, and emphysema. At autopsy, multiple myeloma, diffuse laxity of the skin, and panacinar emphysema were found. The amount of elastic fiber in the skin, lungs, and aorta was decreased and showed abnormal fragmentation. Results of direct immunofluorescence study demonstrated IgG bound to dermal elastic fibers. Speculation regarding an immunologic etiology of the elastic tissue abnormality is presented herein.

Case Report: Multiple Myeloma with Gangrene of Extremities

Directory of Open Access Journals (Sweden)

N Gharahi

2009-07-01

Full Text Available Introduction: Multiple myeloma represents a malignant proliferation of plasma cells derived from a single clone and it results in bone pain or fracture, renal failure, susceptibility to infections, anemia and hypercalcemia. The hyper viscosity syndrome is rare. Cryoglobulins are immunoglubulins that precipitate at temperatures less than 37degrees Celsius. Monoclonal cryoglobulins are usually present along with a specific hematologic disorder and are often asymptomatic. We report a second case of multiple myeloma with gangrene of all four extremities. Case: The Patient was a 77 year–old farmer with a 2 weeks history of coldness, pain and discoloration of the fingers of both the extremities which had extended to the mid forearm and shin regions. It was accompanied by skin erosions of the lower extremities, dark spots on the ear auricles and discoloration of the tip of the nose. On physical examination, quadrigangrene associated with ischemia of the auricles and tip of nose was seen. Serum proteins electrophoresis demonstrated monoclonal gammopathy and serum was positive for cryoglobulin, Bone marrow study showed neoplastic plasma cells infiltration. The patient was diagnosed as cryoglobulinemia based on multiple myeloma and treated accordingly.

The rise and fall of the New Nordic Cuisine

Directory of Open Access Journals (Sweden)

Jonatan Leer

2016-11-01

Full Text Available This article provides a history of the New Nordic Cuisine—the ideology, the politics, the criticism, and the counter-reactions to it. The article has a particular focus on the Copenhagen restaurant scene which has been recognized as the epicenter of the movement, and it argues that after a decade of dominance of the strict Nordic locavorism, the dogmas of New Nordic Cuisine are being challenged from within by a generation of chefs who were brought up in New Nordic restaurants, but they are currently distancing themselves from the movement. A notable example of this new generation is Christian Puglisi, who while holding on to some of the core elements of the New Nordic Cuisine (particularly ideals of sound production and the focus on vegetables refuses the geographical dogmas of the movement and unfolds a cosmopolitan fusion kitchen. The article also discusses how different actors in different contexts have used the New Nordic Cuisine to position themselves in the culinary field either by adhering to or rejecting the concept, and how the example of the New Nordic Cuisine highlights the complex and often contradictory dynamics of the local/global dichotomy in contemporary food and consumer culture.

Migrants and Health in the Nordic welfare states

DEFF Research Database (Denmark)

Greve, Bent

2016-01-01

This article probes into the health of migrants with a focus on the situation in the Nordic universal welfare states. The Nordic welfare states are further compared to each other with a comparison to the EU28 if possible, including investigation of the differences among the four Nordic countries...... socioeconomic factors, such as the impact of economic inequality. Moreover, the healthy migrant paradox cannot be confirmed....

Nordic Walking improves daily physical activities in COPD: a randomised controlled trial

Directory of Open Access Journals (Sweden)

Breyer Marie-Kathrin

2010-08-01

Full Text Available Abstract Background In patients with COPD progressive dyspnoea leads to a sedentary lifestyle. To date, no studies exist investigating the effects of Nordic Walking in patients with COPD. Therefore, the aim was to determine the feasibility of Nordic Walking in COPD patients at different disease stages. Furthermore we aimed to determine the short- and long-term effects of Nordic Walking on COPD patients' daily physical activity pattern as well as on patients exercise capacity. Methods Sixty COPD patients were randomised to either Nordic Walking or to a control group. Patients of the Nordic Walking group (n = 30; age: 62 ± 9 years; FEV1: 48 ± 19% predicted underwent a three-month outdoor Nordic Walking exercise program consisting of one hour walking at 75% of their initial maximum heart rate three times per week, whereas controls had no exercise intervention. Primary endpoint: daily physical activities (measured by a validated tri-axial accelerometer; secondary endpoint: functional exercise capacity (measured by the six-minute walking distance; 6MWD. Assessment time points in both groups: baseline, after three, six and nine months. Results After three month training period, in the Nordic Walking group time spent walking and standing as well as intensity of walking increased (Δ walking time: +14.9 ± 1.9 min/day; Δ standing time: +129 ± 26 min/day; Δ movement intensity: +0.40 ± 0.14 m/s2 while time spent sitting decreased (Δ sitting time: -128 ± 15 min/day compared to baseline (all: p Conclusions Nordic Walking is a feasible, simple and effective physical training modality in COPD. In addition, Nordic Walking has proven to positively impact the daily physical activity pattern of COPD patients under short- and long-term observation. Clinical trial registration Nordic Walking improves daily physical activities in COPD: a randomised controlled trial - ISRCTN31525632

Study of the adhesion interaction using 51Cr labelling method between the myeloma cell lines and the endothelial cells

International Nuclear Information System (INIS)

Zhang Xueguang; Wang Jiangfang; Mao Zijun

1995-06-01

Using 51 Cr labelled multiple myeloma (MM) cell lines U266/XG-7, the regulatory effect of cytokines on the adhesive interaction between myeloma-cell lines U266/XG-7 and the endothelial cells, and the effects of these cytokines on expression of adhesion molecules and secretion of other cytokines were studied. The experimental results were as follows: (1) IL-6 and IL-6 Rgp 130-associated growth factors (such as GM-CSF) are not only myeloma cell growth factors, but also can enhance the adhesion between MM cells and endothelial cells and thus facilitated the metastasis of tumor cells. (2) Cytokines could induce increase in the expression of CD54 and CD44 on the endothelial cells and the secretion of IL-6 and TNF by the endothelial cells. On the other hand, the adhesion could also cause the change of CD11a, CD54, CD44 and VLA-4 on surface of myeloma cells XG-7. Finally, the interaction between MM cells and stromal cells from murine bone marrow could rapidly induce autocrine of IL-6 in human IL-6-dependent MM cells. (3) The interaction between stromal cells and tumor cells regulated by the cytokines and adhesion molecules was a key element in the pathogenesis and development of human MM. Among these factors, VLA-4 might be one of the molecules involved in U266/XG-7-EC interaction. (5 tabs., 8 figs.)

Economic poverty among children and adolescents in the Nordic countries.

Science.gov (United States)

Povlsen, Lene; Regber, Susann; Fosse, Elisabeth; Karlsson, Leena Eklund; Gunnarsdottir, Hrafnhildur

2018-02-01

This study aimed to identify applied definitions and measurements of economic poverty and to explore the proportions and characteristics of children and adolescents living in economic poverty in Denmark, Finland, Iceland, Norway and Sweden during the last decade and to compare various statistics between the Nordic countries. Official data from central national authorities on statistics, national reports and European Union Statistics of income and living conditions data were collected and analysed during 2015-2016. The proportion of Nordic children living in economic poverty in 2014 ranged from 9.4% in Norway to 18.5% in Sweden. Compared with the European Union average, from 2004 to 2014 Nordic families with dependent children experienced fewer difficulties in making their money last, even though Icelandic families reported considerable difficulties. The characteristics of children living in economic poverty proved to be similar in the five countries and were related to their parents' level of education and employment, single-parent households and - in Denmark, Norway and Sweden - to immigrant background. In Finland, poverty among children was linked in particular to low income in employed households. This study showed that economic poverty among Nordic families with dependent children has increased during the latest decade, but it also showed that poverty rates are not necessarily connected to families' ability to make their money last. Therefore additional studies are needed to explore existing policies and political commitments in the Nordic countries to compensate families with dependent children living in poverty.

The Nordic contribution to the English language twin literature.

Science.gov (United States)

Schwartz, R M; Keith, L G; Keith, D M

1986-01-01

This project was inspired by the extensive contribution of Nordic researchers to the English language twin literature. The purpose of the study was to compile a source bibliography of twin literature written at Nordic institutions. The bibliography compiled as a supplement for this paper provides as complete a survey as is possible to obtain in the United States. Our search began with a Medline Computer data base. To make our survey more complete, we cross-referenced and added to this using the Index Medicus, the National Institute of Mental Health Bibliography, Excerpta Medica, specific article references, references provided by Nordic university libraries and Gedda's Estudio dei Gemelli. The full bibliography of 313 references is available at no cost from the Center for the study of multiple Birth, Rm. 476, 333 E. Superior, Chicago, Ill. 60611, U.S.A.

Nordic H{sub 2} energy foresight action report

Energy Technology Data Exchange (ETDEWEB)

Eerola, A [VTT Technology Studies (Finland)

2004-11-01

The Action Report is one of the intermediate outputs of the Nordic H{sub 2} Energy Foresight project. It pools together the results of the Action Workshop that was organised in Espoo, Finland, in March 2004. It includes the views of 28 Nordic experts representing research, industry, government and relevant associations. A number of challenges are faced when introducing hydrogen energy into the Nordic markets. The report discusses these generics and specific challenges concerning the entire hydrogen energy value chain - hydrogen production, hydrogen use in transport, the stationary use of hydrogen - and the required infrastructure. A multi-perspective approach is taken: techno-economic, infrastructural, geographical, ecological, environmental and socio-political issues are all paid attention to. Thereafter the actions needed to realize the Nordic hydrogen energy visions are discussed. The report suggests that the Nordic countries should take an active role in promoting the successful introduction of hydrogen energy and in exploiting the business opportunities provided by the new technology. The suggestions for actions provided by the Nordic experts can be classified into six categories: 1) informing decision-makers and the wider public, 2) carrying out relevant research and development, 3) creating appropriate strategies and policies, 4) obtaining financial support for the technological developments in the transition phase, 5) market creation and intervention, and 6) contribution to international agreements. The report lists a number of specific tasks within each category and identifies the key actors to be involved at Nordic, national and EU-levels. (au)

The Imipridone ONC201 Induces Apoptosis and Overcomes Chemotherapy Resistance by Up-Regulation of Bim in Multiple Myeloma

Directory of Open Access Journals (Sweden)

Yong-sheng Tu

2017-10-01

Full Text Available In multiple myeloma, despite recent improvements offered by new therapies, disease relapse and drug resistance still occur in the majority of patients. Therefore, there is an urgent need for new drugs that can overcome drug resistance and prolong patient survival after failure of standard therapies. The imipridone ONC201 causes downstream inactivation of ERK1/2 signaling and has tumoricidal activity against a variety of tumor types, while its efficacy in preclinical models of myeloma remains unclear. In this study, we treated human myeloma cell lines and patient-derived tumor cells with ONC201. Treatment decreased cellular viability and induced apoptosis in myeloma cell lines, with IC50 values of 1 to 1.5 μM, even in those with high risk features or TP53 loss. ONC201 increased levels of the pro-apoptotic protein Bim in myeloma cells, resulting from decreased phosphorylation of degradation-promoting Bim Ser69 by ERK1/2. In addition, myeloma cell lines made resistant to several standard-of-care agents (by chronic exposure were equally sensitive to ONC201 as their drug-naïve counterparts, and combinations of ONC201 with proteasome inhibitors had synergistic anti-myeloma activity. Overall, these findings demonstrate that ONC201 kills myeloma cells regardless of resistance to standard-of-care therapies, making it promising for clinical testing in relapsed/refractory myeloma.

CISG Nordic: www.cisgnordic.net

DEFF Research Database (Denmark)

2014-01-01

CISG Nordic er en forskningsdatabase hvor den seneste information om den internationale købelovs anvendelse i de Nordiske lande offentliggøres. På hjemmesiden indgår retsafgørelser, bibliografiske noter, FN dokumenter m.m.......CISG Nordic er en forskningsdatabase hvor den seneste information om den internationale købelovs anvendelse i de Nordiske lande offentliggøres. På hjemmesiden indgår retsafgørelser, bibliografiske noter, FN dokumenter m.m....

CISG Nordic: www.cisgnordic.net

DEFF Research Database (Denmark)

2015-01-01

CISG Nordic er en forskningsdatabase hvor den seneste information om den internationale købelovs anvendelse i de Nordiske lande offentliggøres. På hjemmesiden indgår retsafgørelser, bibliografiske noter, FN dokumenter m.m.......CISG Nordic er en forskningsdatabase hvor den seneste information om den internationale købelovs anvendelse i de Nordiske lande offentliggøres. På hjemmesiden indgår retsafgørelser, bibliografiske noter, FN dokumenter m.m....

The Nordic Gender Equality Model

OpenAIRE

Teigen, Mari; Skjeie, Hege

2017-01-01

In this chapter, we investigate the descriptive premises involved in portrayals of a Nordic model of gender equality. Mainly, we focus on the equality dimensions that form the baseline in comparative welfare state research and research on political participation. We outline these dimensions as norms for economic equity and democratic parity. First, we examine whether and how descriptive statistics that assess these two dimensions currently rank Nordic countries compared with other European co...

European Standards and Guidelines in a Nordic Perspective: Joint Nordic Project 2005-2006. ENQA Occasional Papers 11

Science.gov (United States)

Vinther-Jorgensen, Tue, Ed.; Hansen, Signe Ploug, Ed.

2006-01-01

This report presents the results of the joint 2005-06 project of the Nordic Quality Assurance Network in Higher Education (NOQA). The project focused on the European standards and guidelines for quality assurance agencies, examining them in a Nordic perspective. The project aimed at interpreting and clarifying the European standards and guidelines…

Management of high-risk Myeloma: an evidence-based review of treatment strategies.

Science.gov (United States)

Lehners, Nicola; Hayden, Patrick J; Goldschmidt, Hartmut; Raab, Marc-Steffen

2016-08-01

Despite the progress made in the treatment of patients with multiple myeloma over recent decades, a significant cohort with high-risk disease as defined by specific clinical and genetic criteria continue to respond poorly to standard treatment. These patients represent a particular challenge to the treating physician and require early identification as well as personalized treatment strategies. In this review, we discuss the prognostic impact of adverse clinical, radiological and genetic factors, evaluate available scoring systems and highlight key aspects of the therapeutic management of high-risk myeloma. MEDLINE and recent scientific meetings' databases were searched for the keywords 'high-risk' and 'multiple myeloma' and relevant studies relating to both diagnostic and therapeutic approaches were identified. Expert commentary: A case is made for intensive induction using combinations of novel agents, early high-dose therapy supported by autologous stem cell transplantation and the widespread use of maintenance therapies. Novel therapeutic options, especially in the field of immunotherapy, are currently explored in clinical trials and have the potential to further improve outcomes for patients with high-risk multiple myeloma.

Algae as bioindicators for radionuclides in Nordic coastal waters

International Nuclear Information System (INIS)

Neumann, G.; Notter, M.

1991-01-01

During the later part of the 1970's NKS decided to introduce the bladder wrack (Fucus vesiculosus) as a suitable organism for monitoring radionuclides in Nordic coastal waters. During the past few years studies on this subject have been going on to a varying extent in the different Nordic countries. At this miniseminar the participants described different ongoing studies and projects. The lectures are summarized in the abstracts in the appendix, in which the speakers themselves are responsible for their contributions. (au)

The Heritability of Breast Cancer among women in the Nordic Twin Study of Cancer

DEFF Research Database (Denmark)

Möller, Sören; Mucci, Lorelei A; Harris, Jennifer R

2016-01-01

and heritability of breast cancer among 21,054 monozygotic and 30,939 dizygotic female twin pairs from the Nordic Twin Study of Cancer, the largest twin study of cancer in the world. We accounted for left-censoring, right-censoring, as well as the competing risk of death. Results From 1943 through 2010, 3...

A compound chimeric antigen receptor strategy for targeting multiple myeloma.

Science.gov (United States)

Chen, K H; Wada, M; Pinz, K G; Liu, H; Shuai, X; Chen, X; Yan, L E; Petrov, J C; Salman, H; Senzel, L; Leung, E L H; Jiang, X; Ma, Y

2018-02-01

Current clinical outcomes using chimeric-antigen receptors (CARs) against multiple myeloma show promise in the eradication of bulk disease. However, these anti-BCMA (CD269) CARs observe relapse as a common phenomenon after treatment due to the reemergence of either antigen-positive or -negative cells. Hence, the development of improvements in CAR design to target antigen loss and increase effector cell persistency represents a critical need. Here, we report on the anti-tumor activity of a CAR T-cell possessing two complete and independent CAR receptors against the multiple myeloma antigens BCMA and CS1. We determined that the resulting compound CAR (cCAR) T-cell possesses consistent, potent and directed cytotoxicity against each target antigen population. Using multiple mouse models of myeloma and mixed cell populations, we are further able to show superior in vivo survival by directed cytotoxicity against multiple populations compared to a single-expressing CAR T-cell. These findings indicate that compound targeting of BCMA and CS1 on myeloma cells can potentially be an effective strategy for augmenting the response against myeloma bulk disease and for initiation of broader coverage CAR therapy.

Conventional chemotherapy and long-term survival in multiple myeloma patients

International Nuclear Information System (INIS)

Kraj, M; Poglod, R.; Sokolowska, U.; Kruk, B.; Maj, S.

2010-01-01

Objectives. The study was especially focused on the estimation of real frequency of long-term survivals in patients with multiple myeloma and finding common clinical and laboratory features present in long-term surviving patients as possible good prognostic factors. Material and methods. The survey was carried out on 600 multiple myeloma patients diagnosed before the year 2000 and treated with conventional chemotherapy in the Institute of Hematology and Transfusion Medicine in Warsaw in the years 1962-2009. All patients who had fulfilled the requirement of more than seven years of survival from the diagnosis and beginning of treatment for myeloma were included into the study group. Results. Out of 600 studied patients with multiple myeloma 88 (14.7%) survived over 7 years including 45 (7.5%) over 10 years, 11 (1.8 %) over 15 years and 7 (1.1%) over 20 years from the disease diagnosis and beginning of antitumor treatment. Patients with long survival were younger (median age 55 years) at the time of diagnosis than the whole studied group and had normal serum creatinine, calcium and beta2-microglobulin levels. Sixty eight percent of these patients had stage I or II clinical progression, 60% presented with IgG monoclonal protein and 58% with osteolysis. Treatment with melphalan only was given to 18 patients, 30 were treated with melphalan, followed by vincristine, cyclophosphamide, BCNU, doxorubicin and prednisone or dexamethasone. Polychemotherapy was given from the time of the diagnosis to 16 patients, 15 received radiotherapy or 60C o irradiation besides chemotherapy and 9 received new agents: thalidomide, bortezomib, lenalidomide. In 66% of the evaluated cases response to treatment was good and in another 34% stabilization of the proliferative process was achieved. The mean duration of treatment till the achievement of partial response was 10 months, range: 2 - 89 months. The mean duration of good therapeutic response was 70 months. Twelve patients are alive and

The case of a multiple myeloma with hyperlipoproteinaemia

International Nuclear Information System (INIS)

Paluszewska, M.; Bobilewicz, D.; Gigier, A.; Zwolinski, J.; Kuratowska, Z.

1994-01-01

The case of a 52-year-old women with hyperlipoproteinaemia, xantomathosis and multiple myeloma was discussed. The lipid disorder was one of the first symptoms and the base for diagnosis. Hyperlipoproteinaemia was probably due to the monoclonal immunoglobulin and lipoprotein interaction or their impaired catabolism. Lipoprotein lipase activity was normal. Cytostatic therapy led to partial remission of multiple myeloma and lipoproteins concentration became normal. (author)

A Mixed Nordic Experience:

DEFF Research Database (Denmark)

Olsen, Ole Jess; Johnsen, Tor Arnt; Lewis, Philip

2006-01-01

Although the Nordic countries were among the first to develop competition in the electricity industry, it took a long time to make retail competition work. In Norway and Sweden a considerable number of households are actively using the market but very few households are active in Finland and Denm......Although the Nordic countries were among the first to develop competition in the electricity industry, it took a long time to make retail competition work. In Norway and Sweden a considerable number of households are actively using the market but very few households are active in Finland...

Nordic Cancer Registries - an overview of their procedures and data comparability.

Science.gov (United States)

Pukkala, Eero; Engholm, Gerda; Højsgaard Schmidt, Lise Kristine; Storm, Hans; Khan, Staffan; Lambe, Mats; Pettersson, David; Ólafsdóttir, Elínborg; Tryggvadóttir, Laufey; Hakanen, Tiina; Malila, Nea; Virtanen, Anni; Johannesen, Tom Børge; Larønningen, Siri; Ursin, Giske

2018-04-01

The Nordic Cancer Registries are among the oldest population-based registries in the world, with more than 60 years of complete coverage of what is now a combined population of 26 million. However, despite being the source of a substantial number of studies, there is no published paper comparing the different registries. Therefore, we did a systematic review to identify similarities and dissimilarities of the Nordic Cancer Registries, which could possibly explain some of the differences in cancer incidence rates across these countries. We describe and compare here the core characteristics of each of the Nordic Cancer Registries: (i) data sources; (ii) registered disease entities and deviations from IARC multiple cancer coding rules; (iii) variables and related coding systems. Major changes over time are described and discussed. All Nordic Cancer Registries represent a high quality standard in terms of completeness and accuracy of the registered data. Even though the information in the Nordic Cancer Registries in general can be considered more similar than any other collection of data from five different countries, there are numerous differences in registration routines, classification systems and inclusion of some tumors. These differences are important to be aware of when comparing time trends in the Nordic countries.

Social Policy and Economic Development in the Nordic Countries

DEFF Research Database (Denmark)

Kangas, Olli; Palme, Joakim

between democratization and social policy, drawing attention to the role of the state and non-governmental organizations. Social Policy and Economic Development in Nordic Countries examines Nordic social policies on unemployment, social care, family, education and health care policies, and reviews future......This volume examines the relationship between Nordic social policy and economic development from a comparative perspective. It identifies the driving forces behind the development of the Nordic welfare model and the problems and dilemmas the model is facing at present. The book also traces the link...

Evaluation of serial bone X-ray examination in multiple myeloma

Energy Technology Data Exchange (ETDEWEB)

Wahlin, A.; Holm, J.; Osterman, G.; Norberg, B. (University Hospital, Umeaa (Sweden). Dept. of Internal Medicine and Diagnostic Radiology I)

1982-01-01

Fifteen patients with multiple myeloma stage III were treated with a combination of cytostatics and plasmapheresis in a sequential trial running for 60 weeks. Thirteen patients showed clinical improvement and ten a reduction of thieir myeloma protein by at least 50%. Bone X-ray examination was performed every 15 weeks. Progression of bone lesions was seen in one patient, whereas the radiographic picture was unchanged in the others. It is concluded that bone X-ray, although essential in the diagnosis and staging of multiple myeloma, is not suitable for the monitoring of patients during treatment.

Nordic nuclear emergency exercises. Final report

International Nuclear Information System (INIS)

Bennerstedt, T.; Stranden, E.; Salo, A.

1995-01-01

In all Nordic countries, nuclear emergency provisions have been revised following the Chernobyl accident. Local and national exercises are carried out regularly in each country. Several actions have been taken to harmonize the emergency approaches of the Nordic countries. In order to further promote consistent decisions in an emergency situation, two Nordic exercises were conducted in 1993. It was important to see if all five countries (Denmark, Finland, Iceland, Norway and Sweden) responded in a similar way to a given situation, as far as risk assessment and protective measures were concerned. The exercises were mainly aimed at decision makers and advisers of the five national emergency organizations. Thus, the exercises did not include comparison of underlying calculations on, e.g., atmospheric trajectories or transfer of radioactive material from air to ground. Such functions were tested separately in drills that also formed part of the Nordic emergency preparedness program. The exercises included an acute-phase situation (NORA), and a late-phase situation (ODIN). The Nordic exercises aroused international interest, and hence observers from IAEA, OECD/NEA and the European Union were invited to the exercises. NORA was observed by representatives from IAEA (in Finland) and OECD/NEA (in Sweden). ODIN was attended by IAEA (in Sweden) and the European Union (in Norway). Generally speaking, regional exercises such as NORA and ODIN help improve national emergency preparedness planning, organization and operations as well as international coordination. (EG)

Challenges in Nordic Design Research

DEFF Research Database (Denmark)

Andreasen, Mogens Myrup

1996-01-01

Design research has not won a convincing reputation in industry. Nordic research being scattered and small in number of researchers should find its special strengths and focus on creating results, which are based on our peculiar conditions and background.......Design research has not won a convincing reputation in industry. Nordic research being scattered and small in number of researchers should find its special strengths and focus on creating results, which are based on our peculiar conditions and background....

Transport in the Nordic countries

International Nuclear Information System (INIS)

Gustafsson, B.; Pettersson, S.; Vilkamo, S.

1989-01-01

Transport of radioactive material from different fields of operation is well advanced in the Nordic countries: waste from the medical sector, industry, research, and now in increasing amounts from reactor operation, including spent fuel. In the future, waste from decommissioning will also be transported. This report gives the amount of radioactive waste material to be transported in the Nordic countries. Transport routes, transport containers, and transport systems are described. Legislations and transport regulatins are discussed. (author)

Nordic Seniors on the Move

DEFF Research Database (Denmark)

”I believe that all people need to move about. Actually, some have difficulties in doing so. They stay in their home neighbourhoods where they’ve grown up and feel safe. I can understand that, but my wife and I, we didn’t want that. We are more open to new ideas.” This anthology is about seniors...... on the move. In seven chapters, Nordic researchers from various disciplines, by means of ethnographic methods, attempt to comprehend the phenomenon of Nordic seniors who move to leisure areas in their own or in other countries. The number of people involved in this kind of migratory movement has grown...... above gives voice to one of these seniors, stressing the necessity of moving. The anthology contributes to the international body of literature about later life migration, specifically representing experiences made by Nordic seniors. As shown here, mobility and migration in later life have implications...

Agricultural Exposures, Multiple Myeloma Etiology: Profile of Jonathan Hofmann

Science.gov (United States)

Tenure-track investigator Jonathan Hofmann, Ph.D., M.P.H., has established a research program in the Occupational and Environmental Epidemiology Branch focused on the role of agricultural exposures in the etiology of multiple myeloma and other cancers, and on understanding the biological mechanisms that influence the development and progression of multiple myeloma.

Nordic Walking and the Isa Method for Breast Cancer Survivors: Effects on Upper Limb Circumferences and Total Body Extracellular Water - a Pilot Study.

Science.gov (United States)

Di Blasio, Andrea; Morano, Teresa; Napolitano, Giorgio; Bucci, Ines; Di Santo, Serena; Gallina, Sabina; Cugusi, Lucia; Di Donato, Francesco; D'Arielli, Alberto; Cianchetti, Ettore

2016-12-01

The negative side effects of breast cancer treatments can include upper limb lymphoedema. The growing literature indicates that Nordic walking is an effective discipline against several disease symptoms. The aim of this study was to determine whether introduction to Nordic walking alone is effective against total body extracellular water and upper limb circumferences in breast cancer survivors compared to its combination with a series of specifically created exercises (i.e. the Isa method). 16 breast cancer survivors (49.09 ± 2.24 years) were recruited and randomly assigned to 1 of 2 different training groups. 10 lessons on Nordic walking technique plus the Isa method significantly reduced both extracellular body water and the extracellular-to-total body water ratio (p = 0.01 for both), and also the circumference of the upper limb, (both relaxed arm and forearm circumferences) (p = 0.01 for all), whereas Nordic walking alone did not. Introduction to Nordic walking does not seem to affect lymphoedema in breast cancer survivors. This might be because novice Nordic Walkers do not adequately generate an effective muscular pump through coordination of the alternated bimanual open-close cycle. The Isa method appears to close this gap.

Radiotherapy in the treatment of multiple myeloma.

Science.gov (United States)

Bosch, A; Frias, Z

1988-12-01

Fifty-nine patients with multiple myeloma referred for treatment of painful bony lesions received irradiation to 95 local areas, and 16 of the 59 were irradiated using hemibody techniques. Pain relief was obtained in practically all of the irradiated regions. Most local areas were treated to doses of 3000 cGy in 10 to 15 fractions. Patients with generalized pain due to multiple site involvement were treated with single dose hemibody irradiation, to doses of 600 cGy to the upper hemibody, and of 800 cGy to the lower hemibody. This treatment was well tolerated and side effects minimal. Median survival from diagnosis was 30 months and the survival at 1, 3, and 5 years was 80%, 42%, and 12% respectively. Key articles on radiation therapy of multiple myeloma are reviewed and discussed. Since all patients eventually relapse after chemotherapy, the role of radiotherapy using present techniques should be fully evaluated and considered as an alternative in the primary treatment of multiple myeloma.

Anaesthesia nursing education in the Nordic countries: Literature review.

Science.gov (United States)

Jeon, Yunsuk; Lahtinen, Pia; Meretoja, Riitta; Leino-Kilpi, Helena

2015-05-01

The purpose of this review was to analyse post-registration anaesthesia nursing education in the Nordic countries. The analysis was based on key determinants fundamental to analysing nursing education: 1) the sys]tem of anaesthesia nursing education, 2) entry requirements, 3) credits, the duration and the title or degree awarded, and 4) the amount of practical training. A scoping review was approached in a systematic manner. The literature was analysed using deductive content analysis. Data was gathered based on key determinants. The data were quantified into frequencies and percentages to compare the similarities and differences of anaesthesia nursing. The Nordic countries have different types of post-registration anaesthesia nursing education from non-degree supplementary programmes to Master's degree programmes. Even though the entry requirements correspond between countries, many more differences than similarities in anaesthesia nursing education were noted. A title granting the right to work as a nurse anaesthetist can be obtained through a variety of educational systems, credit requirements, the duration, and the amount of practical training in post-registration anaesthesia nursing programmes. This aim of the study was to analyse post-registration anaesthesia nursing education from the Nordic perspective. Harmonising the educational system and minimum education requirements in anaesthesia nursing education is recommended in order to facilitate free movement and assure the quality of care from the Nordic perspective. Since each Nordic country has its own native language, it was difficult to gather information from all the Nordic countries. Therefore, creating common educational database published in English can help to bench mark each country's educational system. Copyright © 2015 Elsevier Ltd. All rights reserved.

The Imipridone ONC201 Induces Apoptosis and Overcomes Chemotherapy Resistance by Up-Regulation of Bim in Multiple Myeloma.

Science.gov (United States)

Tu, Yong-Sheng; He, Jin; Liu, Huan; Lee, Hans C; Wang, Hua; Ishizawa, Jo; Allen, Joshua E; Andreeff, Michael; Orlowski, Robert Z; Davis, Richard E; Yang, Jing

2017-10-01

In multiple myeloma, despite recent improvements offered by new therapies, disease relapse and drug resistance still occur in the majority of patients. Therefore, there is an urgent need for new drugs that can overcome drug resistance and prolong patient survival after failure of standard therapies. The imipridone ONC201 causes downstream inactivation of ERK1/2 signaling and has tumoricidal activity against a variety of tumor types, while its efficacy in preclinical models of myeloma remains unclear. In this study, we treated human myeloma cell lines and patient-derived tumor cells with ONC201. Treatment decreased cellular viability and induced apoptosis in myeloma cell lines, with IC50 values of 1 to 1.5 μM, even in those with high risk features or TP53 loss. ONC201 increased levels of the pro-apoptotic protein Bim in myeloma cells, resulting from decreased phosphorylation of degradation-promoting Bim Ser69 by ERK1/2. In addition, myeloma cell lines made resistant to several standard-of-care agents (by chronic exposure) were equally sensitive to ONC201 as their drug-naïve counterparts, and combinations of ONC201 with proteasome inhibitors had synergistic anti-myeloma activity. Overall, these findings demonstrate that ONC201 kills myeloma cells regardless of resistance to standard-of-care therapies, making it promising for clinical testing in relapsed/refractory myeloma. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Nuclear threats in the vicinity of the Nordic countries. A database, Nordic Nuclear Safety Research

International Nuclear Information System (INIS)

Margrethe, I.; Eikelmann, H.

2003-01-01

The acute phase of an accident and the possibility of high exposure of the populations are always the most important threats in the emergency preparedness work. Radioactive contamination from an accident can however also cause long time effects for land use and enhanced doses to special population groups and economic problems for agriculture, grazing animals, reindeer industry, hunting, freshwater fishing, tourism and recreation. For planning purposes it is always valuable to be aware of potential radiation hazard and other potential threats in the vicinity of the Nordic countries. Thus, mapping such threats in a Nordic context is an important factor in emergency preparedness in the Nordic countries. The project has dealt with threats from the north west of Russia and the Baltic states. The results from the different activities in the project is generated in a web based database called the 'the base of knowledge'. (orig.)

Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells

DEFF Research Database (Denmark)

Standal, Therese; Seidel, Carina; Hjertner, Øyvind

2002-01-01

Multiple myeloma (MM) is a hematologic malignancy characterized by accumulation of plasma cells in the bone marrow (BM). Bone destruction is a complication of the disease and is usually associated with severe morbidity. The balance between receptor activator of nuclear factor-kappaB (NF-kappaB......) ligand and osteoprotegerin (OPG) is of major importance in bone homeostasis. We have recently shown that serum OPG levels are lower in patients with myeloma than in healthy individuals. Here we show that myeloma cells can bind, internalize, and degrade OPG, thereby providing a possible explanation...... for the lower levels of OPG in the BM of patients with MM. This process is dependent on interaction of OPG with heparan sulfates on the myeloma cells. The results suggest a novel biologic mechanism for the bone disease associated with MM and that treatment of the bone disease with OPG lacking the heparin...

Reinterpreting the Historicity of the Nordic Model

Directory of Open Access Journals (Sweden)

Pauli Kettunen

2012-11-01

Full Text Available In conventional images of the so-called Nordic model, the strong state is opposed to markets or civil society and co-operation is opposed to conflict. These opposites appear problematic if one takes seriously the Nordic market- and interest-centered language used for the practices of social regulation, including the stubborn use of “labor market parties” instead of the EU concept “social partners”. Applying an approach sensitive to the historical and political aspects of language and concepts, the paper argues that a particular notion of social citizenship developed in the Nordic countries, in which interests rather than rights were put into the center. Such a notion of social citizenship was associated with two intertwined ideas, important in the development of the Nordic pattern of social reform: the idea of symmetry between workers and employers and the idea of a virtuous circle between divergent interests. With these ideas democracy and citizenship were combined with paid work and conflicting interests. This combination has been questioned by the projects for competitive national (and European communities, responding to globalized and financialized capitalism. The vigorous comparisons of “models”, and the popularity of the concept of “the Nordic model”, can be seen as an aspect of this current transformation.

Nordic noir and lifted localities

DEFF Research Database (Denmark)

Hansen, Kim Toft

What I do here is to draw attention to a particular visual quality of recent Nordic noir and to relate the visuality of TV-drama to what I – with a term borrowed from Roland Robertson – dub lifted localites.......What I do here is to draw attention to a particular visual quality of recent Nordic noir and to relate the visuality of TV-drama to what I – with a term borrowed from Roland Robertson – dub lifted localites....

The expression of p53 protein in patients with multiple myeloma

Directory of Open Access Journals (Sweden)

Marković Olivera

2007-01-01

Full Text Available Introduction: Although mutations of p53 are one of the most often acquired genetic changes in malignant tumors, these mutations are rare events in patients with newly diagnosed multiple myeloma (MM. Moreover, there are a few literature data about clinical significance of p53 overexpression in multiple myeloma. Objective The aim of our study was to evaluate the clinical significance of p53 immunoexpression in multiple myeloma. Method A total of 58 patients with newly diagnosed MM (26 females and 32 males, mean age 62 years were enrolled in the study. The diagnosis of MM was made according to criteria of Chronic Leukemia-Myeloma Task Force. Clinical staging was done according to Durie and Salmon classification (4 patients had disease stage I, 15 patients stage II and 39 patients stage III. The histological grade and histological stage were determined according to predominant plasma cell morphology and volume of myeloma infiltration, respectively. Standard immunohistochemical analysis with p53 antibody in B5-fixed and paraffin- embedded bone marrow specimens was used to evaluate the expression of p53 in myeloma cells. The specimens were considered positive when ≥5% of plasma cells exhibited clear nuclear positivity. Results Out of 58 patients, p53 expression was detected in 9 (15.52%. No significant correlation was found between p53 expression and clinical stage (I+II vs. III, Я2-microglobulin level (≤6 mg/L vs. >6mg/L, histological grade (I vs. II+III, histological stage (<20% vs. 21-50% vs. >50% and the extent of osteolytic lesions (≤3 vs. >3 lesions. Median survival of patients with p53 immunoreactivity in =>5% of plasma cells was 10 months, whilst median survival of patients with p53 immunoreactivity in <5% of plasma cells was 36 months. However, such difference was not significant (p=0.2. Conclusion The frequency of p53 immunoexpression in our group of newly diagnosed MM was relatively low. Although p53 immunoexpression was not

Trends in perinatal health after assisted reproduction: a Nordic study from the CoNARTaS group.

Science.gov (United States)

Henningsen, A A; Gissler, M; Skjaerven, R; Bergh, C; Tiitinen, A; Romundstad, L B; Wennerholm, U B; Lidegaard, O; Nyboe Andersen, A; Forman, J L; Pinborg, A

2015-03-01

Has the perinatal outcome of children conceived after assisted reproductive technology (ART) improved over time? The perinatal outcomes in children born after ART have improved over the last 20 years, mainly due to the reduction of multiple births. A Swedish study has shown a reduction in unwanted outcomes over time in children conceived after ART. Our analyses based on data from more than 92 000 ART children born in four Nordic countries confirm these findings. Nordic population-based matched cohort study with ART outcome and health data from Denmark, Finland, Norway and Sweden. We analysed the perinatal outcome of 62 379 ART singletons and 29 758 ART twins, born from 1988 to 2007 in four Nordic countries. The ART singletons were compared with a control group of 362 215 spontaneously conceived singletons. Twins conceived after ART were compared with all spontaneously conceived twins (n = 122 763) born in the Nordic countries during the study period. The rates of several adverse perinatal outcomes were stratified into the time periods: 1988-1992; 1993-1997; 1998-2002 and 2003-2007 and presented according to multiplicity. For singletons conceived after ART, a remarkable decline in the risk of being born preterm and very preterm was observed. The proportion of ART singletons born with a low and very low birthweight also decreased. Finally, the stillbirth and infant death rates have declined among both ART singletons and twins. Throughout the 20 year period, fewer ART twins were stillborn or died during the first year of life compared with spontaneously conceived twins, presumably due to the lower proportion of monozygotic twins among the ART twins. We were not able to adjust for some potential confounders such as BMI, smoking, length or cause of infertility. The Nordic ART populations have changed over time, and in recent years, both less as well as severely reproductive ill couples are being treated. This may have affected the observed trends. It is assuring that

State-of-the-Art Management of Complications of Myeloma and Its Treatment

Directory of Open Access Journals (Sweden)

Monique A. Hartley-Brown

2010-01-01

Full Text Available Multiple myeloma is an incurable disease, although patient survival has increased with the availability of novel agents. Both multiple myeloma and its therapies often affect the renal, immune, skeletal, hematologic, and nervous systems. The resulting organ dysfunctions often impair the quality of life of affected patients, complicate and limit subsequent therapies, and may result in significant mortality. Research on the treatment of complications of multiple myeloma has been limited; hence, preventative and management strategies for patients with these complications are heterogeneous and often based on anecdotal experience. In this paper, we review the effects of myeloma and the novel therapies on organ systems and suggest management strategies.

Maternal and infant characteristics: differences and similarities between the Nordic countries and the US.

Science.gov (United States)

Löfling, Lukas; Bröms, Gabriella; Bahmanyar, Shahram; Kieler, Helle

2016-01-01

Data from the Nordic health care registers have been of great value in perinatal epidemiological research. It has been assumed that findings from the Nordic population (Denmark, Finland, Iceland, Norway, and Sweden) are applicable to other populations as well, including the population of the US. To describe and compare maternal and infant characteristics between the Nordic and the American populations as recorded in the official statistics. This population-based study included data on all females who gave birth and their infants in the Nordic countries and the US. The data were obtained from the US National Center for Health Statistics and the official statistics data for the Nordic countries. The data from all six countries included births from 2006 to 2010. The mean maternal age at delivery was lower in the US than in the Nordic countries (27.5 vs 30.3 years). Cesarean sections (32.2% vs 17.9%), low birth weight (8.2% vs 4.8%), and preterm birth (12.3% vs 5.9%) were more common in the US than in the Nordic countries. Smoking during early pregnancy was slightly less common in the US compared with Nordic countries (9.8% vs 11.2%). Restricting the data from the US to females with a university degree, characteristics such as age at delivery, birth weight, and preterm deliveries were more in alignment with the Nordic data. There are differences in some key maternal and neonatal characteristics between the Nordic countries and the US. However, some characteristics are related to socioeconomic status, suggesting that the Nordic data seem to be applicable to the part of the population in the US with a higher socioeconomic status.

Naturally occurring radioactivity in the Nordic countries. Recommendations

International Nuclear Information System (INIS)

2000-01-01

In the publication 'Naturally Occurring Radiation in the Nordic Countries - Recommendations' published in 1986 the radiation protection authorities in Denmark, Finland, Iceland, Norway and Sweden gave radiation protection recommendations for natural radiation in the Nordic countries. The exposure of the populations in the Nordic countries to natural radiation sources is among the highest in the world and much effort has been devoted during the last 10 to 20 years to characterising, assessing and, where feasible, to reduce these exposures. The exposure of workers to natural radiation sources has also been an important area of work in the same period. During this period the international recommendations on radiation protection policy have been further developed with ICRP Publication 60: '1990 Recommendations of the International Commission on Radiological Protection', and ICRP Publication 65: 'Protection Against Radon-222 at Home and at Work'. The European Basic Safety Standards Directive from 1996 (96/29/EURATOM), which is based on the ICRP recommendations, differs from the earlier versions in that special provisions have been laid down concerning exposure to natural radiation sources. As Denmark, Finland and Sweden are members of European Union and the EFTA-countries (Iceland and Norway) have close co-operation with the EU, the practical implementation of the EU-BSS will play an important role in all the Nordic countries. In November 1998, a new Drinking Water Directive, 98/83/EC, was adopted. The directive also includes radioactivity in drinking water, excluding potassium-40, radon, and radon decay products. Altogether this means that the Nordic recommendations from 1986 for natural radiation needed to be updated. The Nordic Radiation Protection Authorities therefore decided to set up a working group with the aim of revising the recommendations from 1986. The new revised recommendations will, as before, only deal with the components of the exposure to natural

Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin

International Nuclear Information System (INIS)

Olsen, O E; Wader, K F; Misund, K; Våtsveen, T K; Rø, T B; Mylin, A K; Turesson, I; Størdal, B F; Moen, S H; Standal, T; Waage, A; Sundan, A; Holien, T

2014-01-01

Multiple myeloma is a malignancy of plasma cells predominantly located in the bone marrow. A number of bone morphogenetic proteins (BMPs) induce apoptosis in myeloma cells in vitro, and with this study we add BMP-9 to the list. BMP-9 has been found in human serum at concentrations that inhibit cancer cell growth in vitro. We here show that the level of BMP-9 in serum was elevated in myeloma patients (median 176 pg/ml, range 8–809) compared with healthy controls (median 110 pg/ml, range 8–359). BMP-9 was also present in the bone marrow and was able to induce apoptosis in 4 out of 11 primary myeloma cell samples by signaling through ALK2. BMP-9-induced apoptosis in myeloma cells was associated with c-MYC downregulation. The effects of BMP-9 were counteracted by membrane-bound (CD105) or soluble endoglin present in the bone marrow microenvironment, suggesting a mechanism for how myeloma cells can evade the tumor suppressing activity of BMP-9 in multiple myeloma

Nordic Cuisine, but National Identities: Nordic Cuisines and the Gastronationalist Projects of Denmark and Sweden

DEFF Research Database (Denmark)

Neuman, Nicklas; Leer, Jonatan

2017-01-01

This article is a cross-national comparison of how food is promoted on tourism websites offering information about Denmark and Sweden – two countries with big national projects targeting the promotion of culinary excellence, following the initiation of “New Nordic Cuisine” (NNC) in 2004. The aim...... is to study similarities and differences in the projects of these two countries, both quantitatively and qualitatively. 19 out of 32 (approx. 59%) Danish texts referred to a shared Nordic culinary identity, whereas this was only the case in five out 51 (approx. 10%) of the Swedish texts. Moreover......, the qualitative analysis also revealed that “Nordic” cuisine was almost interchangeably connected to Danish cuisine, while in Sweden NNC was more peripheral and culinary excellence was construed as specifically Swedish. We thus criticise the generally accepted idea that NNC is a post-national food movement...

Psoriatic arthritis mutilans (PAM) in the Nordic countries

DEFF Research Database (Denmark)

Gudbjornsson, B; Ejstrup, L; Gran, J T

2013-01-01

To determine the prevalence and clinical characteristics of psoriatic arthritis mutilans (PAM) in the Nordic countries.......To determine the prevalence and clinical characteristics of psoriatic arthritis mutilans (PAM) in the Nordic countries....

Challenges for Nordic VET-systems

DEFF Research Database (Denmark)

Jørgensen, Christian Helms

2015-01-01

, this challenge is not new. It has been on the agenda since the late 1960s following the crisis for apprenticeship and the growing demand for equal access to all levels of education. What is new, however, is that the challenge has intensified and the solutions developed since the 1970s don’t appear tenable today......The systems of vocational education and training (VET) in the Nordic Countries all face a similar challenge: to offer double qualifications. The Nordic VET-systems are expected to give access not only to skilled employment, but also to higher education. As an increasing share of young people....... This situation calls for new solutions to tackle the challenge of double qualifications. The question, which I will examine in this chapter, is how the Nordic VET-systems have handled this challenge in different ways and what these systems can learn from Switzerland, which is often highlighted as a model...

Nordic Narratives of the Second World War : National Historiographies Revisited

OpenAIRE

2011-01-01

How have the dramatic events of the Second World War been viewed in the Nordic countries? In Nordic Narratives of the Second World War, leading Nordic historians analyse post-war memory and historiography. They explore the relationship between scholarly and public understandings of the war. How have national interpretations been shaped by official security-policy doctrines? And in what way has the end of the Cold War affected the Nordic narratives? The authors not only present the ...

The Nordic difference: Job quality in Europe 1995–2010

Directory of Open Access Journals (Sweden)

Tomi Oinas

2012-11-01

Full Text Available Previous empirical research has pointed out that Nordic countries are distinguished from the rest of Europe in terms of job quality. On the other hand, it has been debated whether, in the longer run, the Nordic welfare state is able to insulate workers from globalization effects. This article investigates whether Nordic countries have retained their advantageous position concerning job quality compared with other EU countries. Empirical analyses are based on the European Working Conditions Survey collected in 1995, 2000, 2005, and 2010. We use data on employees in the 15 member states of the EU prior to enlargement in 2004 (n = 61,457. The results partly confirm previous findings of high job quality in the Nordic countries. However, there are clear differences between Nordic countries. To be precise, Denmark stands out from the rest of Europe and other Nordic countries with its higher level of job quality.

Milestones in Nordic Health Promotion research.

Science.gov (United States)

Haglund, Bo J A; Tillgren, Per

2018-02-01

Based on the storytelling tradition and analyses of conference material, this article provides an overview of the evolving Nordic Health Promotion Research Network (NHPRN) and its conferences over the last 20 years. The story goes from the planning of the first conference in Bergen, Norway, back in 1996 to the eighth conference in Jyväskylä, Finland, in 2016. There have been three phases of development. During the first phase, 1996-2007, the five first conferences were initiated and implemented by departments of public health in the Nordic countries. The World Health Organization (WHO) collaborative centres of Health Promotion in Bergen University and a group at Karolinska Institute, Department of Social Medicine, creating supportive environments for health in Stockholm played key roles in initiating and supporting NHPRN. During the second phase, 2007-2014, the network was strengthened and supported by the Nordic School of Public Health (NHV) in Gothenburg. The third phase started when NHV closed down in 2015 and networking activities were transferred to the European Office of WHO in Copenhagen. The Nordic Health Promotion Research Conference series has served several purposes and will continue to do so. They are important Nordic meeting places, stimulating Health Promotion research, as well as explicitly managing ongoing concerns in the international Health Promotion community. This is reflected in the shift of foci over time. The content of the conferences has been highly responsive to whatever challenges are particularly relevant at different points in time, while also contributing to developing Health Promotion as a discipline, given that every conference has built on the previous ones.

Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo

Energy Technology Data Exchange (ETDEWEB)

Cheong, Chee Man [Myeloma Research Laboratory, School of Medical Sciences, University of Adelaide, and South Australian Health and Medical Research Institute (SAHMRI), Adelaide 5000, SA (Australia); Chow, Annie W.S. [Myeloma Research Laboratory, School of Medical Sciences, University of Adelaide, and South Australian Health and Medical Research Institute (SAHMRI), Adelaide 5000, SA (Australia); Department of Haematology, SA Pathology, Adelaide 5000, SA (Australia); Fitter, Stephen [Myeloma Research Laboratory, School of Medical Sciences, University of Adelaide, and South Australian Health and Medical Research Institute (SAHMRI), Adelaide 5000, SA (Australia); Hewett, Duncan R. [Myeloma Research Laboratory, School of Medical Sciences, University of Adelaide, and South Australian Health and Medical Research Institute (SAHMRI), Adelaide 5000, SA (Australia); School of Medicine, University of Adelaide, Adelaide 5005, SA (Australia); Martin, Sally K. [Myeloma Research Laboratory, School of Medical Sciences, University of Adelaide, and South Australian Health and Medical Research Institute (SAHMRI), Adelaide 5000, SA (Australia); Department of Haematology, SA Pathology, Adelaide 5000, SA (Australia); School of Medicine, University of Adelaide, Adelaide 5005, SA (Australia); Williams, Sharon A. [Myeloma Research Laboratory, School of Medical Sciences, University of Adelaide, and South Australian Health and Medical Research Institute (SAHMRI), Adelaide 5000, SA (Australia); To, L. Bik [Department of Haematology, SA Pathology, Adelaide 5000, SA (Australia); and others

2015-03-01

Background: Increased expression of the tetraspanin TSPAN7 has been observed in a number of cancers; however, it is unclear how TSPAN7 plays a role in cancer progression. Methods: We investigated the expression of TSPAN7 in the haematological malignancy multiple myleoma (MM) and assessed the consequences of TSPAN7 expression in the adhesion, migration and growth of MM plasma cells (PC) in vitro and in bone marrow (BM) homing and tumour growth in vivo. Finally, we characterised the association of TSPAN7 with cell surface partner molecules in vitro. Results: TSPAN7 was found to be highly expressed at the RNA and protein level in CD138{sup +} MM PC from approximately 50% of MM patients. TSPAN7 overexpression in the murine myeloma cell line 5TGM1 significantly reduced tumour burden in 5TGM1/KaLwRij mice 4 weeks after intravenous adminstration of 5TGM1 cells. While TSPAN7 overexpression did not affect cell proliferation in vitro, TSPAN7 increased 5TGM1 cell adhesion to BM stromal cells and transendothelial migration. In addition, TSPAN7 was found to associate with the molecular chaperone calnexin on the cell surface. Conclusion: These results suggest that elevated TSPAN7 may be associated with better outcomes for up to 50% of MM patients. - Highlights: • TSPAN7 expression is upregulated in newly-diagnosed patients with active multiple myeloma. • Overexpression of TSPAN7 inhibits myeloma tumour development in vivo. • TSPAN7 interacts with calnexin at the plasma membrane in a myeloma cell line.

Radiography and bone scintigraphy in multiple myeloma: a comparative analysis

International Nuclear Information System (INIS)

Ludwig, H.; Kumpan, W.; Sinzinger, H.

1982-01-01

The sensitivity of radionuclide imaging for detecting skeletal lesions was compared with that of radiography by evaluating 573 different anatomical sites in 41 patients with multiple myeloma. Radiography revealed a significantly greater number of myeloma-related bone lesions than did radionuclide imaging. Of the 179 myeloma-related bone lesions detected when both techniques were applied, 163 were seen by radiography and 82 by radionuclide imaging. Ninety-seven lesions were detected by radiography alone and 16 lesions seen by scintiscanning only, yielding a sensitivity of 91% for the former and of 46% for the latter technique. Radionuclide imaging proved superior to radiography only occasionally in the rib cage, and rarely in other anatomical sites. These findings suggest that radiography is the method of first choice in obtaining a skeletal survey in patients with multiple myeloma. In cases with continued pain, unexplained by standard radiography, the skeletal survey should be supplemented by tomography and radionuclide imaging. (author)

Trading with electric power in the Nordic countries

International Nuclear Information System (INIS)

1992-01-01

During recent years Nordic cooperation has contributed to a greater integration of the Nordic electric power markets. This has been based on trade on a short-term basis. As a part of increased integration in Europe and the demand for more effective administration of Nordic energy resources, trade with electric power has become more significant. At the same time environmental challenges have lead to an increase in Nordic and European cooperation, also within the energy sector. The aim of the seminar held in Hankoe, Norway, on June 9-11, 1992 was to discuss the problems within this field. Both theoretical and practical aspects were dealt with and developments in Europe and environmental issues were in focus. The lectures given at the seminar are included in this publication. (AB)

Nuclear threats in the vicinity of the Nordic countries. Supplementary final report of the Nordic Nuclear Safety research

International Nuclear Information System (INIS)

Eikelmann, I.M.H.

2006-04-01

The purpose of this project was to continue the cross-disciplinary study SBA-1 'base of knowledge' in the NKS research program 1998-2001 regarding possible nuclear threats in the vicinity of the Nordic countries. The main task for the project was to expand and envelope this database. Finding information to be placed in the database and identifying and filling gaps in knowledge were prioritised. This is a continuous process which extends beyond the end of this project, in order to have an operating and updated database also in the years to come. In this project work has been done making information systems in Norway that can take care of the database in the future. The scope of the preceding project was to prepare a base of knowledge regarding possible nuclear threats in the vicinity of the Nordic countries. The database, including a literature database, is presented on the website 'Nuclear threats in the vicinity of the Nordic Countries'. The utilisation of modern information technology gives the user of the database easy access to information on different types of nuclear installations and threats. The project focused on potential events at nuclear installations and the consequences for the Nordic countries, especially with regards to vulnerable food chains, doses to man, environmental contamination and emergency preparedness systems. The geographical area dealt with includes North-west Russia and the Baltic states and the nuclear installations investigated are nuclear power plants, ship reactors and storage and handling of used fuel and radioactive waste. (au)

Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma.

Science.gov (United States)

Stewart, A Keith; Rajkumar, S Vincent; Dimopoulos, Meletios A; Masszi, Tamás; Špička, Ivan; Oriol, Albert; Hájek, Roman; Rosiñol, Laura; Siegel, David S; Mihaylov, Georgi G; Goranova-Marinova, Vesselina; Rajnics, Péter; Suvorov, Aleksandr; Niesvizky, Ruben; Jakubowiak, Andrzej J; San-Miguel, Jesus F; Ludwig, Heinz; Wang, Michael; Maisnar, Vladimír; Minarik, Jiri; Bensinger, William I; Mateos, Maria-Victoria; Ben-Yehuda, Dina; Kukreti, Vishal; Zojwalla, Naseem; Tonda, Margaret E; Yang, Xinqun; Xing, Biao; Moreau, Philippe; Palumbo, Antonio

2015-01-08

Lenalidomide plus dexamethasone is a reference treatment for relapsed multiple myeloma. The combination of the proteasome inhibitor carfilzomib with lenalidomide and dexamethasone has shown efficacy in a phase 1 and 2 study in relapsed multiple myeloma. We randomly assigned 792 patients with relapsed multiple myeloma to carfilzomib with lenalidomide and dexamethasone (carfilzomib group) or lenalidomide and dexamethasone alone (control group). The primary end point was progression-free survival. Progression-free survival was significantly improved with carfilzomib (median, 26.3 months, vs. 17.6 months in the control group; hazard ratio for progression or death, 0.69; 95% confidence interval [CI], 0.57 to 0.83; P=0.0001). The median overall survival was not reached in either group at the interim analysis. The Kaplan-Meier 24-month overall survival rates were 73.3% and 65.0% in the carfilzomib and control groups, respectively (hazard ratio for death, 0.79; 95% CI, 0.63 to 0.99; P=0.04). The rates of overall response (partial response or better) were 87.1% and 66.7% in the carfilzomib and control groups, respectively (P<0.001; 31.8% and 9.3% of patients in the respective groups had a complete response or better; 14.1% and 4.3% had a stringent complete response). Adverse events of grade 3 or higher were reported in 83.7% and 80.7% of patients in the carfilzomib and control groups, respectively; 15.3% and 17.7% of patients discontinued treatment owing to adverse events. Patients in the carfilzomib group reported superior health-related quality of life. In patients with relapsed multiple myeloma, the addition of carfilzomib to lenalidomide and dexamethasone resulted in significantly improved progression-free survival at the interim analysis and had a favorable risk-benefit profile. (Funded by Onyx Pharmaceuticals; ClinicalTrials.gov number, NCT01080391.).

Platelet factor-4 and its p17-70 peptide inhibit myeloma proliferation and angiogenesis in vivo

International Nuclear Information System (INIS)

Yang, Longjiang; Du, Juan; Hou, Jian; Jiang, Hua; Zou, Jianfeng

2011-01-01

Angiogenesis plays an important role in the development of multiple myeloma (MM). The interaction between MM cells and the bone marrow microenvironment stimulates the proliferation and migration of endothelial progenitor cells (EPCs). Vascular endothelial growth factor (VEGF) contributes to the formation of new blood vessels by actively recruiting circulating EPCs. The production of proangiogenic and antiangiogenic factors is also dysregulated in MM. Platelet factor 4 (PF4) is a potent angiostatic cytokine that inhibits angiogenesis and tumor growth in several animal models. In this study, we stably transfected human myeloma cell lines with the PF4 gene or the sequence encoding its more potent p17-70 peptide and investigated the effects of PF4 and p17-70 on angiogenesis and tumor growth in vitro and in a SCID-rab myeloma model. PF4 and p17-70 significantly attenuated VEGF production, both in vitro and in vivo. In a migration study using a Transwell system, PF4 or p17-70 markedly suppressed the migration of co-cultured human endothelial progenitor cells. PF4 or p17-70 also caused a significant reduction in microvessel densities in myeloma xenografts and markedly reduced the tumor volume in the SCID mice. Kaplan-Meier analysis demonstrated that PF4 and p17-70 significantly extended the overall survival of SCID mice bearing human myeloma xenografts. Our findings indicate that PF4 or p17-70 could be valuable in combating multiple myeloma by disrupting tumor angiogenesis

Nordic Summer School on Parallel Computing in Optimization

CERN Document Server

Pardalos, Panos; Storøy, Sverre

1997-01-01

During the last three decades, breakthroughs in computer technology have made a tremendous impact on optimization. In particular, parallel computing has made it possible to solve larger and computationally more difficult prob­ lems. This volume contains mainly lecture notes from a Nordic Summer School held at the Linkoping Institute of Technology, Sweden in August 1995. In order to make the book more complete, a few authors were invited to contribute chapters that were not part of the course on this first occasion. The purpose of this Nordic course in advanced studies was three-fold. One goal was to introduce the students to the new achievements in a new and very active field, bring them close to world leading researchers, and strengthen their competence in an area with internationally explosive rate of growth. A second goal was to strengthen the bonds between students from different Nordic countries, and to encourage collaboration and joint research ventures over the borders. In this respect, the course bui...

PardNor - PARameters for ingestion dose models for NORdic areas

Energy Technology Data Exchange (ETDEWEB)

Nielsen, Sven P.; Andersson, K.G. (Technical Univ. of Denmark, Risoe National Lab. for Sustainable Energy, Roskilde (Denmark))

2008-07-15

A review of the foodchain ECOSYS model, which is applied in the European standard decision support systems ARGOS and RODOS, has identified a number of points where elaboration is deemed necessary before ECOSYS should be relied on for Nordic decision making. The present study has been performed to update the ECOSYS model, which in a number of ways does not reflect current state-of-the-art knowledge, and to obtain country-specific data. It is the aim of the PardNor project to collect new data, and thus enable the targeted use of ECOSYS for scenarios involving contamination of specific Nordic areas. The effort in 2007 is targeted on identifying location-specific Nordic data sets describing the typical human diets, fractions of imported food items and animal feeding regimes. For each of the Nordic countries, a dataset has been established describing the typical diets for four different age groups, ranging from young children to senior adults. A comparison of the datasets shows that there are significant differences between consumption rates of some of the important food items. For instance, the average consumption of milk varies by a factor of 4-5 among the Nordic countries, and consumption of leafy vegetables varies by a factor of almost 4. Due to the differences in climate among the Nordic countries and also compared to Southern Germany, for which the default ECOSYS values apply, there are also very significant differences in the production regimes of some food items. Since some countries import practically the entire consumption of some major food items, it is important to generally examine the import patterns for the different Nordic countries. Due to the complexity of current international trade routes, unexpectedly high import fractions were found for some food items, for which the production in the given countries was much more than sufficient to cover the home market. ECOSYS calculations for a scenario showed that the differences in consumption and production

PardNor - PARameters for ingestion dose models for NORdic areas

International Nuclear Information System (INIS)

Nielsen, Sven P.; Andersson, K.G.

2008-07-01

A review of the foodchain ECOSYS model, which is applied in the European standard decision support systems ARGOS and RODOS, has identified a number of points where elaboration is deemed necessary before ECOSYS should be relied on for Nordic decision making. The present study has been performed to update the ECOSYS model, which in a number of ways does not reflect current state-of-the-art knowledge, and to obtain country-specific data. It is the aim of the PardNor project to collect new data, and thus enable the targeted use of ECOSYS for scenarios involving contamination of specific Nordic areas. The effort in 2007 is targeted on identifying location-specific Nordic data sets describing the typical human diets, fractions of imported food items and animal feeding regimes. For each of the Nordic countries, a dataset has been established describing the typical diets for four different age groups, ranging from young children to senior adults. A comparison of the datasets shows that there are significant differences between consumption rates of some of the important food items. For instance, the average consumption of milk varies by a factor of 4-5 among the Nordic countries, and consumption of leafy vegetables varies by a factor of almost 4. Due to the differences in climate among the Nordic countries and also compared to Southern Germany, for which the default ECOSYS values apply, there are also very significant differences in the production regimes of some food items. Since some countries import practically the entire consumption of some major food items, it is important to generally examine the import patterns for the different Nordic countries. Due to the complexity of current international trade routes, unexpectedly high import fractions were found for some food items, for which the production in the given countries was much more than sufficient to cover the home market. ECOSYS calculations for a scenario showed that the differences in consumption and production

New Nordic and Scandinavian Retro: reassessment of values and aesthetics in contemporary Nordic design

Directory of Open Access Journals (Sweden)

Niels Peter Skou

2016-11-01

Full Text Available The “New Nordic” label has spread in the design world since 2005, but it is quite difficult to distinguish from the image of “Scandinavian Design” and the heritage of values and aesthetics from the 1950s. Many designer statements and promotional texts are eager to mention both designations. This survey sketches the background and asks, “What is ‘New’?” and “What is ‘Nordic’?” with a focus on the Danish firm Muuto, which has been a central actor in establishing the term “New Nordic Design.” We focus on the interplay between the storytelling around the products and designers on webpages and in marketing, popular literature, etc., and the actual design objects. Reoccurring themes from the 1950s are how it relates to nature and climate, social models of welfare and equality, and pure, minimalist forms. They are, however, more present in the high expectations of an international audience and in promotions than in the objects themselves. The new products of Nordic Design are close to the current international neo-modernism in the form of digitally designed and industrially produced items in often thought-provoking minimalist forms and are directed at an elitist, international audience that wants to engage with these demanding aesthetics and the ideal picture of Nordic cultures—as a nice design and gourmet destination. New Nordic Design shows that the image and ideals of Scandinavian Modern are still living, as a subtle version of Scandinavian Retro, a reimagination of the lifestyle and values of Scandinavian Modern.

Imaging of multiple myeloma and related monoclonal plasma cell diseases. An update

International Nuclear Information System (INIS)

Weber, Marc-Andre; Delorme, Stefan; Hillengass, Jens

2014-01-01

Multiple myeloma is a hematologic disorder characterized by the infiltration and proliferation of monoclonal plasma cells mainly in the bone marrow. The main symptoms are hypercalcemia, renal impairment, cytopenia/anemia and bone disease - summarized as CRAB-criteria. Symptomatic multiple myeloma is consistently preceded by asymptomatic premalignant stages called monoclonal gammopathy of undetermined significance and smoldering multiple myeloma. Staging of multiple myeloma is based on the measurement of the monoclonal protein in serum and urine as well as the assessment of impairment of hematopoiesis, renal function and mineralized bone. In the last decade the development of novel therapeutic agents has led to an increase in response rates and survival time of patients with multiple myeloma, which further stresses the value of response assessment by imaging. Cross sectional imaging like MRI and CT is currently replacing conventional radiological surveys in the initial work-up and follow-up of patients with monoclonal plasma cell diseases. The added value of MRI is to improve initial staging by unraveling a diffuse infiltration of bone marrow by plasma cells, a focal pattern or a combination of both. Furthermore, a complete remission of myeloma confirmed by MRI and CT goes along with a better prognosis compared to a complete response based only on serological parameters.

Plan of Nordic research in nuclear safety 1994-97

International Nuclear Information System (INIS)

1993-04-01

A new four-year Nordic research programme in the field of nuclear safety and radiation protection is to start in 1994 as a followup of several preceding Nordic programmes. It will include seven projects and a joint coordination function. The programme is intended to sustain a common understanding among safety authorities in the Nordic countries with respect to reactor safety and radiation protection. It mainly deals with questions that are actual within the Nordic region, but it may also include problems of concern to its eastern neighbours. Two of the projects deal with reactor safety, and one with radioactive waste. The other four projects are on environmental aspects: two of them deal with radioecology, and two with questions related to emergency preparedness. The programme is managed by the Nordic Committee for Safety Research, NKS, consisting of representatives from regulatory authorities, research bodies, and industry. Basic financing is provided by one consortium member from each of the five Nordic countries, whereby an annual budget of approximately 8 million Danish Kroner will be provided. Additional financing comes from sponsors interested in the programme as well as from those organizations taking part in the project work. Definite project plans are to be elaborated within the more general frames described in the present outline. The flexibility of the programme is enhanced by limiting the duration of individual activities to one or two years. This will make it possible to adjust the programme to actual needs in the Nordic countries. (au)

Ibrutinib targets microRNA-21 in multiple myeloma cells by inhibiting NF-κB and STAT3.

Science.gov (United States)

Ma, Jing; Gong, Wei; Liu, Su; Li, Qian; Guo, Mengzheng; Wang, Jinhan; Wang, Suying; Chen, Naiyao; Wang, Yafei; Liu, Qiang; Zhao, Hui

2018-01-01

The oncogenic microRNA-21 contributes to the pathogenesis of multiple myeloma. Ibrutinib (also referred to as PCI-32765), an inhibitor of Bruton's tyrosine kinase, while its effects on multiple myeloma have not been well described. Here, we show that microRNA-21 is an oncogenic marker closely linked with progression of multiple myeloma. Moreover, ibrutinib attenuates microRNA-21 expression in multiple myeloma cells by inhibiting nuclear factor-κB and signal transducer and activator of transcription 3 signaling pathways. Taken together, our results suggest that ibrutinib is a promising potential treatment for multiple myeloma. Further investigation of mechanisms of ibrutinib function in multiple myeloma will be necessary to evaluate its use as a novel multiple myeloma treatment.

Smoldering multiple myeloma: prevalence and current evidence guiding treatment decisions

Directory of Open Access Journals (Sweden)

Blum A

2018-04-01

Full Text Available Agnieszka Blum, Despina Bazou, Peter O’Gorman Department of Hematology, Mater Misericordiae University Hospital, Dublin, UK Abstract: Smoldering multiple myeloma (SMM is an asymptomatic plasma cell proliferative disorder associated with risk of progression to symptomatic multiple myeloma (MM or amyloidosis. In comparison to monoclonal gammopathy of undetermined significance (MGUS, SMM has a much higher risk of progression to MM. Thanks to advances in our understanding of the risk factors, the subset of patients with ultra-high risk of progression to MM (80%–90% at 2 years has been identified. The revision of the diagnostic criteria resulted in changes in the management of this cohort of patients. In contrast to the management guidelines for MGUS patients, SMM patients need to be studied more intensively in order to identify biomarkers necessary for accurate risk stratification. In this review, we focus on the risk of progression from SMM to MM, as well as the influence of early treatment on overall survival, time to progression and quality of life. Keywords: smoldering multiple myeloma, risk factor, biomarker, genomic aberrations, glycan analysis

Drug addict deaths in the Nordic countries: a study based on medicolegally examined cases in the five Nordic countries in 1991

DEFF Research Database (Denmark)

Steentoft, Anni; Teige, Brita; Holmgren, Per

1996-01-01

The study includes medicolegally examined deaths among drug addicts in 1991 in the five Nordic countries: Denmark, Finland, Iceland, Norway and Sweden. A common definition of ‘drug addict’ was applied by the participating countries. The greatest number of drug addict deaths per 105 inhabitants...... was observed in Denmark followed, in descending order by Norway, Sweden, Finland and finally Iceland with only four deaths. The main difference between the countries was found in the number of fatal poisonings. The distribution according to geographical regions showed that about half of all drug addict deaths...

Early myeloma-related death in elderly patients: development of a clinical prognostic score and evaluation of response sustainability role.

Science.gov (United States)

Rodríguez-Otero, Paula; Mateos, María Victoria; Martínez-López, Joaquín; Martín-Calvo, Nerea; Hernández, Miguel-Teodoro; Ocio, Enrique M; Rosiñol, Laura; Martínez, Rafael; Teruel, Ana-Isabel; Gutiérrez, Norma C; Bargay, Joan; Bengoechea, Enrique; González, Yolanda; de Oteyza, Jaime Pérez; Gironella, Mercedes; Encinas, Cristina; Martín, Jesús; Cabrera, Carmen; Palomera, Luis; de Arriba, Felipe; Cedena, María Teresa; Paiva, Bruno; Puig, Noemí; Oriol, Albert; Bladé, Joan; Lahuerta, Juan José; San Miguel, Jesús F

2018-02-23

Although survival of elderly myeloma patients has significantly improved there is still a subset of patients who, despite being fit and achieving optimal responses, will die within 2 years of diagnosis due to myeloma progression. The objective of this study was to define a scoring prognostic index to identify this group of patients. We have evaluated the outcome of 490 newly diagnosed elderly myeloma patients included in two Spanish trials (GEM2005-GEM2010). Sixty-eight patients (13.8%) died within 2 years of diagnosis (early deaths) due to myeloma progression. Our study shows that the use of simple scoring model based on 4 widely available markers (elevated LDH, ISS 3, high risk CA or >75 years) can contribute to identify up-front these patients. Moreover, unsustained response (<6 months duration) emerged as one important predictor of early myeloma-related mortality associated with a significant increase in the risk of death related to myeloma progression. The identification of these patients at high risk of early death is relevant for innovative trials aiming to maintain the depth of first response, since many of them will not receive subsequent lines of therapy.

Taking part in Nordic collaboration; nursing students' experiences and perceptions from a learning perspective: A qualitative study.

Science.gov (United States)

Westerbotn, Margareta; Kneck, Åsa; Hovland, Olav Johannes; Elrond, Malene; Pedersen, Ingrid; Lejonqvist, Gun-Britt; Dulavik, Johild; Ecklon, Tove; Nilsson, Inga-Lill; Sigurdardottir, Árún K

2015-05-01

Nordic networking of different kinds has a long tradition aiming to increase collaboration and understanding between citizens in different countries. Cultural competence in relation to health care and nursing is important for clinical nurses and is a central issue in nurse education. To gain an understanding of what nurse students experienced and learned during an intensive course in diabetes together with students and nurse educators from Denmark, Finland, Iceland, Norway, Sweden and the Faroe Islands. In 2012, an intensive course within the Nordic network, Nordkvist, was conducted in Faroe Islands with the theme "Nursing - to live a good life with diabetes". To answer the objective of the study, 26 students conducted written reflections based on two questions. The data was analyzed using qualitative content analysis. Through meetings with nurse students and educators from the Nordic countries the intensive course strengthened the students' identification with the nursing profession. The students gained new perspectives on diabetes, such as how complex it can be to live with a chronic illness. Because of the difficulties in understanding one another and because of different mother tongues, the students gained a better understanding of patients' vulnerability in relation to hospital jargon and how it felt to be in an unfamiliar place. The intensive course increased the students' personal and professional growth, cross-cultural competence, and their identification with nursing. Students' understanding of health care in the Nordic countries improved as similarities and differences were recognized. Copyright © 2015 Elsevier Ltd. All rights reserved.

Healthcare resource use and costs associated with chronic kidney disease in US private insurance patients with multiple myeloma.

Science.gov (United States)

Bhowmik, Debajyoti; Song, Xue; Intorcia, Michele; Kent, Shia T; Shi, Nianwen

2018-01-01

Objectives Within a median 1.2 years after patients have an initial diagnosis with multiple myeloma, up to 61% were diagnosed with renal impairment and 50% were diagnosed with chronic kidney disease. This study estimated economic burden associated with chronic kidney disease in multiple myeloma patients in the US. Methods In this retrospective cohort study, patients ≥18 years old with ≥1 inpatient or ≥ 2 outpatient multiple myeloma diagnoses between 1 January 2008 and 31 March 2015 were identified from MarketScan® Commercial and Medicare Supplemental Databases. Chronic kidney disease patients had ≥1 diagnosis of chronic kidney disease Stages 1-5 (first chronic kidney disease diagnosis date = index date) on or after the first multiple myeloma diagnosis, and were propensity score matched 1:1 to multiple myeloma patients without chronic kidney disease, end-stage renal disease, dialysis, or other type of chronically impaired renal function. All patients had ≥six-month continuous enrollment prior to index date and were followed for ≥one month from index date until the earliest of inpatient death, end of continuous enrollment, or end of the study period (30 September 2015). The per-patient per-year healthcare resource utilization and costs were measured during follow-up. Costs were total reimbursed amount in 2016 US dollars. Results A total of 2541 multiple myeloma patients with chronic kidney disease stages 1-5 and 2541 matched controls met the study criteria and were respectively 69.3 and 69.6 years, 54.5% and 55.3% men, and had 572.2 and 533.4 mean days of follow up. Compared to controls, chronic kidney disease patients had significantly (all P chronic kidney disease, end-stage renal disease, or dialysis had $78,455 ( P chronic kidney disease in patients with multiple myeloma was estimated to be between $34,754 and $78,455 per-patient per-year. Given its substantial clinical and economic impact, preservation of renal function is important in

Late diagnosis of multiple myeloma: a case report

Science.gov (United States)

Syahreza, A.; Gatot, D.; Mardia, A. I.

2018-03-01

Multiple myeloma is a challenging hematologic case to handle. Sometimes the disease is diagnosed too late for the patient and doctor. Therefore, careful approaches are needed to manage the patient. A 66-year-old mansuffersfrom low back pain since one year before he came to the hospital. He was diagnosed multiple compression fractures by orthopedic and had undergone two surgeries in one year. Punched out lesions werein skull radiology and lumbar compression in lumbar MRI. After further investigation, plasmacytoma and M protein in urine electrophoresis were founded. Significant improvement found after bortezomib and dexamethasone were given.Diagnosis and management of multiple myeloma is a challenge for a doctor. Systematically approach is needed for a patient with a recurrent fracture. Even a novel therapies are not widely available in our country.We reported a late diagnosis of multiple myeloma and had a significant improvement after bortezomib and dexamethasone therapy.

Nordic research infrastructures for plant phenotyping

Directory of Open Access Journals (Sweden)

Kristiina Himanen

2018-03-01

Full Text Available Plant phenomics refers to the systematic study of plant phenotypes. Together with closely monitored, controlled climates, it provides an essential component for the integrated analysis of genotype-phenotype-environment interactions. Currently, several plant growth and phenotyping facilities are under establishment globally, and numerous facilities are already in use. Alongside the development of the research infrastructures, several national and international networks have been established to support shared use of the new methodology. In this review, an overview is given of the Nordic plant phenotyping and climate control facilities. Since many areas of phenomics such as sensor-based phenotyping, image analysis and data standards are still developing, promotion of educational and networking activities is especially important. These facilities and networks will be instrumental in tackling plant breeding and plant protection challenges. They will also provide possibilities to study wild species and their ecological interactions under changing Nordic climate conditions.

Grid investments in a Nordic perspective. Report to EMG

Energy Technology Data Exchange (ETDEWEB)

2010-05-15

In a letter of 20 November 2008, the Electricity Market Group (EMG) under the Nordic Council of Ministers requested NordREG to carry out an assignment related to transmission network investments in the Nordic countries. The assignment to NordREG was divided into two tasks; to map the differences in the legislation and licensing processes in the Nordic countries and to analyse these differences and possible ways of financing common network investment projects. In the second half of 2009 the consultant Econ Poeyry was engaged to support in the finalisation of this project, mainly concerning possibilities for Nordic financing. The final text is however the sole responsibility of the task force. A draft version of the final report was delivered to EMG in December 2009. At the same time the report was sent to the Nordic TSOs together with an invitation to a workshop at Gardermoen on 26 January 2010. The comments from the TSOs are included in appendix 2 of the report

Current research in transcultural psychiatry in the Nordic countries

DEFF Research Database (Denmark)

Ekblad, Solvig; Kastrup, Marianne Carisius

2013-01-01

This article discusses major themes in recent transcultural psychiatric research in the Nordic countries from 2008 to 2011: (a) epidemiological studies of migration, (b) indigenous populations, and (c) quality of psychiatric care for migrants. Over the past several decades, the populations......, and after migration, with potential effects on their physical, mental, social, and spiritual health. Growing interest in transcultural issues is reflected in the level of scientific research and clinical activity in the field by Nordic physicians, psychologists, social scientists, demographers, medical...

Iodine status in the Nordic countries - past and present.

Science.gov (United States)

Nyström, Helena Filipsson; Brantsæter, Anne Lise; Erlund, Iris; Gunnarsdottir, Ingibjörg; Hulthén, Lena; Laurberg, Peter; Mattisson, Irene; Rasmussen, Lone Banke; Virtanen, Suvi; Meltzer, Helle Margrete

2016-01-01

Adequate iodine nutrition is dependent on ground water content, seafood, and, as many countries use iodized cow fodder, dairy products. In most countries, salt fortification programs are needed to assure adequate iodine intake. The objectives are threefold: 1) to describe the past and present iodine situation in the Nordic countries, 2) to identify important gaps of knowledge, and 3) to highlight differences among the Nordic countries' iodine biomonitoring and fortification policies. Historical data are compared with the current situation. The Nordic countries' strategies to achieve recommended intake and urine iodine levels and their respective success rates are evaluated. In the past, the iodine situation ranged from excellent in Iceland to widespread goiter and cretinism in large areas of Sweden. The situation was less severe in Norway and Finland. According to a 1960 World Health Organization (WHO) report, there were then no observations of iodine deficiency in Denmark. In Sweden and Finland, the fortification of table salt was introduced 50-75 years ago, and in Norway and Finland, the fortification of cow fodder starting in the 1950s helped improve the population's iodine status due to the high intake of milk. In Denmark, iodine has been added to household salt and salt in bread for the past 15 years. The Nordic countries differ with regard to regulations and degree of governmental involvement. There are indications that pregnant and lactating women, the two most vulnerable groups, are mildly deficient in iodine in several of the Nordic countries. The Nordic countries employ different strategies to attain adequate iodine nutrition. The situation is not optimal and is in need of re-evaluation. Iodine researchers, Nordic national food administrations, and Nordic governmental institutions would benefit from collaboration to attain a broader approach and guarantee good iodine health for all.

2nd Nordic NJF Seminar on Reindeer Husbandry Research "Reindeer herding and land use management - Nordic perspectives"

Directory of Open Access Journals (Sweden)

Päivi Soppela

2015-06-01

Full Text Available The 2nd NJF Seminar on Reindeer Husbandry Research was held at the Arctic Centre, University of Lapland, Rovaniemi, Finland from 19 to 21 October 2014. The seminar was organised under the framework of Reindeer Husbandry Research Section of NJF (Nordic Association of Agricultural Scientists, established in 2012. Over 100 Nordic and international delegates including researchers, managers, educators, students and reindeer herders participated in the seminar.

Carbon leakage from a Nordic perspective

Energy Technology Data Exchange (ETDEWEB)

Naess-Schmidt, S.; Hansen, Martin Bo; Sand Kirk, J. [Copenhagen Economics, Copenhagen (Denmark)

2012-02-15

Carbon pricing is generally considered a highly effective tool in reducing carbon emissions. Putting a price on carbon provides incentives for users and producers of fossil fuels to reduce consumption and develop low carbon products and processes. However, pursuing an ambitious climate policy can lead to carbon leakage, which refers to a situation where unilateral or regional climate change policy drives the relocation of industry investments and installations, and associated emissions, to third countries. This report by Copenhagen Economics has been commissioned by the Nordic Council of Ministers to give an overview of the industries at risk of carbon leakage in the Nordic countries, and estimate the expected extent of carbon leakage from unilateral climate policies in the Nordic countries. The report also assesses available policy options that may reduce the risk of carbon leakage, such as exemptions from energy tax and exemptions from quota obligations under green certificate schemes. The key drivers of carbon leakage are identified, which include energy intensity, product differentiation, transportation costs and capital intensity. The analysis suggests that industries such as paper and pulp, iron and steel, aluminium, cement, pharmaceuticals, chemicals, and fertilizers are most at risk of carbon leakage in the Nordic manufacturing sector. (Author)

Toddlers in Nordic Early Childhood Education and Care

DEFF Research Database (Denmark)

Hansen, Ole Henrik; Greve, Anne

2018-01-01

-called Nordic model represents a uni ed system of early childhood education and care (ECEC). This chapter underlines the distinctive shared characteristics of the Nordic approach to play and learning, and care and education, where participation, democracy, respect for other cultures and religions...... and character of the Nordic people. Here, there is a strong foundation in an ideal of freedom, democracy, equality, in uence and sustainability, but also a focus on education that emphasises the toddler as a learning being. However, toddlers in ECEC represent an area in need of more attention and new research....

Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease

DEFF Research Database (Denmark)

Fu, Jing; Li, Shirong; Feng, Rentian

2016-01-01

Multiple myeloma (MM) cells secrete osteoclastogenic factors that promote osteolytic lesions; however, the identity of these factors is largely unknown. Here, we performed a screen of human myeloma cells to identify pro-osteoclastogenic agents that could potentially serve as therapeutic targets...

Cogeneration and taxation in a liberalised Nordic power market

International Nuclear Information System (INIS)

Jess Olsen, O.; Munksgaard, J.

1997-01-01

This report is about the impact of the liberalisation of the Nordic power market on cogeneration of heat and power. Special attention is given to the effects on competition of the entirely different tax regimes in the Nordic countries. Some of the main questions answered in this study are: Which cogeneration technologies are able to compete on a liberalised power market? What are the consequences of different tax structures in the four countries for cross-border competition? Which principles should be applied if a common Nordic tax structure is to be developed? The following countries are included in the study: Denmark, Finland, Norway and Sweden. Today, cogeneration provides a larger contribution to the energy supply in the Nordic countries than elsewhere in the world. Our analysis demonstrates that most cogeneration technologies can compete with the power-only technologies. This is the case with respect to both long- and short-term marginal costs. The main exception is the very expensive straw-fired cogeneration technology. The analysis is extended to include the effects of the existing tax regimes (in 1996) in Denmark, Finland and Sweden as well as of the combines energy/CO 2 -tax that was proposed in 1992 by the European Commission. Each of the four tax regimes preserve the competitiveness of cogeneration within its own regime, i.e. if a given cogeneration technology is competitive without taxes it will remain so in a closed market when either Danish, Finnish, Swedish or European taxes are added. The implication of this is that the same cogeneration technology will be exposed to very different conditions in an open power market with cross-border competition, if the present tax regimes in the Nordic countries are allowed to continue. (EG) Also published in Danish. 15 refs

Cogeneration and taxation in a liberalised Nordic power market

Energy Technology Data Exchange (ETDEWEB)

Jess Olsen, O.; Munksgaard, J.

1997-12-31

This report is about the impact of the liberalisation of the Nordic power market on cogeneration of heat and power. Special attention is given to the effects on competition of the entirely different tax regimes in the Nordic countries. Some of the main questions answered in this study are: Which cogeneration technologies are able to compete on a liberalised power market? What are the consequences of different tax structures in the four countries for cross-border competition? Which principles should be applied if a common Nordic tax structure is to be developed? The following countries are included in the study: Denmark, Finland, Norway and Sweden. Today, cogeneration provides a larger contribution to the energy supply in the Nordic countries than elsewhere in the world. Our analysis demonstrates that most cogeneration technologies can compete with the power-only technologies. This is the case with respect to both long- and short-term marginal costs. The main exception is the very expensive straw-fired cogeneration technology. The analysis is extended to include the effects of the existing tax regimes (in 1996) in Denmark, Finland and Sweden as well as of the combines energy/CO{sub 2}-tax that was proposed in 1992 by the European Commission. Each of the four tax regimes preserve the competitiveness of cogeneration within its own regime, i.e. if a given cogeneration technology is competitive without taxes it will remain so in a closed market when either Danish, Finnish, Swedish or European taxes are added. The implication of this is that the same cogeneration technology will be exposed to very different conditions in an open power market with cross-border competition, if the present tax regimes in the Nordic countries are allowed to continue. (EG) Also published in Danish. 15 refs.

Multiple myeloma and central nervous system involvement: experience of a Brazilian center.

Science.gov (United States)

Dias, Ana Luiza Miranda Silva; Higashi, Fabiana; Peres, Ana Lúcia M; Cury, Pricilla; Crusoé, Edvan de Queiroz; Hungria, Vânia Tietsche de Moraes

The estimated involvement of the central nervous system in patients with multiple myeloma is rare at about 1%. The infiltration can be identified at the time multiple myeloma is diagnosed or during its progression. However, it is more common in refractory disease or during relapse. This retrospective cohort study reviewed data from medical records of patients followed up at the Gammopathy Outpatient Clinic of Santa Casa de Misericórdia de São Paulo from January 2008 to December 2016. Twenty patients were included, with a median follow-up of 33.5 months after central nervous system infiltration. The prevalence was 7%. The median age at diagnosis of multiple myeloma was 56.1 years, with 70% of participants being female. Sixteen patients had central nervous system infiltration at diagnosis of multiple myeloma. Seventeen patients had exclusive osteodural lesions and three had infiltrations of the leptomeninge, of which one had exclusive involvement and two had associated osteodural lesions. The median overall survival was 40.3 months after central nervous system involvement. The median overall survival in the group with central nervous system infiltration at relapse was 7.4 months. The patients with leptomeningeal involvement had a median overall survival of 5.8 months. Central nervous system infiltration is a rare condition, but it should be considered as a possibility in patients with multiple myeloma and neurological symptoms. The best treatment regimen for this condition remains unknown and, in most cases, the prognosis is unfavorable. Copyright © 2017. Published by Elsevier Editora Ltda.

Interleukin-6, a new target for therapy in multiple myeloma?

NARCIS (Netherlands)

van Oers, M. H.; van Zaanen, H. C.; Lokhorst, H. M.

1993-01-01

During the past few years much insight has been gained into the immunobiology of multiple myeloma. It has become evident that the growth of myeloma cells is regulated by cytokines, notably interleukin-6. In this paper a brief review is given of the evidence derived from in vitro as well as in vivo

Association between metformin use and progression of monoclonal gammopathy of undetermined significance to multiple myeloma in US veterans with diabetes mellitus: a population-based retrospective cohort study.

Science.gov (United States)

Chang, Su-Hsin; Luo, Suhong; O'Brian, Katiuscia K; Thomas, Theodore S; Colditz, Graham A; Carlsson, Nils P; Carson, Kenneth R

2015-01-01

Multiple myeloma is one of the most common haematological malignancies in the USA and is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS). We aimed to assess the association between metformin use and progression of MGUS to multiple myeloma. We did a retrospective cohort study of patients registered in the US Veterans Health Administration database and diagnosed with MGUS between Oct 1, 1999, and Dec 31, 2009. We included patients (aged >18 years) with at least one International Classification of Diseases (9th revision) code for diabetes mellitus and one treatment for their diabetes before MGUS diagnosis. We reviewed patient-level clinical data to verify diagnoses and extract any available data for size of baseline M-protein and type of MGUS. We defined metformin users as patients with diabetes who were given metformin consistently for 4 years after their diabetes diagnosis and before multiple myeloma development, death, or censorship. Our primary outcome was time from MGUS diagnosis to multiple myeloma diagnosis. We used Kaplan-Meier curves and Cox models to analyse the association between metformin use and MGUS progression. We obtained data for 3287 patients, of whom 2003 (61%) were included in the final analytical cohort. Median follow-up was 69 months (IQR 49–96). 463 (23%) participants were metformin users and 1540 (77%) participants were non-users. 13 (3%) metformin users progressed to multiple myeloma compared with 74 (5%) non-users. After adjustment, metformin use was associated with a reduced risk of progression to multiple myeloma (hazard ratio 0·47, 95% CI 0·25–0·87). For patients with diabetes diagnosed with MGUS, metformin use for 4 years or longer was associated with a reduced risk of progression of MGUS to multiple myeloma. Prospective studies are needed to establish whether this association is causal and whether these results can be extrapolated to non-diabetic individuals. Barnes-Jewish Hospital Foundation

Development of a joint Nordic master in cold climate engineering within the Nordic five tech alliance

DEFF Research Database (Denmark)

Kirkelund, Gunvor Marie; Tuhkuri, Jukka; Høyland, Knut V.

2017-01-01

, Nordic Five Tech, which was established in 2006 with the goal of utilizing the shared and complementary strengths of the universities and creating synergies, also within education in the form of joint master programmes. The Cold Climate Engineering students study for one year at two of the universities...

PREFACE: 16th Nordic Semiconductor Meeting

Science.gov (United States)

Pétur Gíslason, Hafliði; Guðmundsson, Viðar

1994-01-01

Some 30 years ago an informal meeting of the few Nordic specialists in semiconductor physics marked the beginning of what has become a biannual meeting of some hundred physicists and physics students from all the Nordic countries. The 16th Nordic Semiconductor Meeting took place at Laugarvatn, Iceland, June 12-15,1994. As a regional meeting the Nordic Semiconductor meeting has three characteristic features all of which distinguish it from more traditional international meetings in the field. First, it has the purpose of promoting Nordic cooperation in the international field of semiconductor physics. Research in the fields of advanced science and technology in the Nordic countries is likely to benefit from joining national forces before participating in the increasing European integration. Second, there is an unusually large fraction of graduate students amongst the participants of the Nordic Semiconductor Meeting. In fact, attending this conference is traditionally a part of the graduate program in seniconductor physics and technology. The Nordic Semiconductor Meeting is often the first conference of international character that graduate students attend in order to present a paper of poster. Third, there is an interdisciplinary quality of the meeting which is normally not the case for meetings of this size. In particular, the number of professional scientists from industry is comparable to the number of their academic colleagues. This is important for both groups, but perhaps the graduate students benefit most from presenting their results to both groups. The 16th Nordic Semiconductor Meeting, the first one in this series held in Iceland, attracted 129 active participants. The scientific programme was divided in twelve oral sessions. A novelty of this meeting was the emphasis on more fundamental physics in one of the two parallel sessions but more applied topics in the other, although the distinction was sometimes a matter of predilection. A poster session

Computed Tomography diagnosis of skeletal involvement in multiple myeloma

International Nuclear Information System (INIS)

Scutellari, Pier Nuccio; Galeotti, Roberto; Leprotti, Stefano; Piva, Nadia; Spanedda, Romedio

1997-01-01

The authors assess the role of Computed Topography in the diagnosis and management of multiple myeloma (MM) and investigate if Computed Tomography findings can influence the clinical approach, prognosis and treatment. 273 multiple myeloma patients submitted to Computed Tomography June 1994, to December, 1996. The patients were 143 men and 130 women (mean age: 65 years): 143 were stage I, 38 stage II and 92 stage III according to Durie and Salomon's clinical classification. All patients were submitted to blood tests, spinal radiography and Computed Tomography, the latter with serial 5-mm scans on several vertebral bodies. Computed Tomography despicted vertebral arch and process involvement in 3 cases with the vertebral pedicle sign. Moreover, Computed Tomography proved superior to radiography in showing the spread of myelomatous masses into the soft tissues in a case with solitary permeative lesion in the left public bone, which facilitated subsequent biopsy. As for extraosseous localizations, Computed Tomography demonstrated thoracic soft tissue (1 woman) and pelvic (1 man) involvement by myelomtous masses penetrating into surrounding tissues. In our series, only a case of osteosclerotic bone myeloma was observed in the pelvis, associated with lytic abnormalities. Computed Tomography findings do not seem to improve the clinical approach and therapeutic management of the disease. Nevertheless, the authors reccommend Computed Tomography for some myelomatous conditions, namely: a) in the patients with focal bone pain but normal skeletal radiographs; b) in the patients with M protein, bone marrow plasmocytosis and back pain, but with an incoclusive multiple myeloma diagnosis; c) to asses bone spread in the regions which are anatomically complex or difficult to study with radiography and to depict soft tissue involvement; d) for bone biopsy

Model of Nordic energy market

International Nuclear Information System (INIS)

Gjelsvik, E.; Johnsen, T.; Mysen, H.T.

1992-01-01

Simulation results are given of the consumption of electricity and oil in Denmark, Norway and Sweden based on the demand section of a Nordic energy market model which is in the process of being developed in Oslo under the auspices of the Nordic Council of Ministers. The model incorporates supply, and trade between countries so that it can be analyzed how trading can contribute to goals within energy and environmental policies and to cost effective activities aimed at reducing pollution. The article deals in some detail with the subject of how taxation on carbon dioxide emission can influence pollution abatement and with energy consumption development within individual sectors in individual Northern countries. The model of energy demand is described with emphasis on the individual sectors of industry, transport, service and private households. Simulation results giving the effects of energy consumption and increased taxation on fossil fuels are given. On this background the consequences of the adaption of power plants is discussed and a sketch is given of a Nordic electric power market incorporating trading. (AB) (15 refs.)

Energy research and development projects in the Nordic countries. Directory 1987

International Nuclear Information System (INIS)

Anon.

1988-01-01

This is the fifth directory of research, development and demonstration projects in the Nordic countries within the field of energy. The directory includes projects running in 1987. 2378 projects are described, all of them financed through special public funds (i.e. external funding). The energy research organisation in each Nordic country is briefly reviewed in the appendixes, and a list of relevant newsletters are given. The directory is published at the request of the Nordic Council of Ministers and a special Energy Research Committee set up by the Nordic energy ministers in order to coordinate and promote Nordic information sharing in the energy field. (author)

Radiation protection legislation in the Nordic countries

International Nuclear Information System (INIS)

Persson, L.

1992-01-01

A close collaboration exists in the Nordic countries in the field of radiation protection. The radiation protection authorities attach major importance to a uniform interpretation of the international recommendations. The legal situation of the Nordic countries in the radiation protection field will be reviewed with the main emphasis on the new Swedish and Finnish laws. (author)

CUTANEOUS INVOLVEMENT IN MULTIPLE MYELOMA AT AN UNUSUAL SITE: A RARE CASE REPORT

Directory of Open Access Journals (Sweden)

Lohit Kumar

2015-05-01

Full Text Available Multiple myeloma is a rare cancer. According to the most recent data from the Surveillance, Epidemiology, and End Results (SEER program, multiple myeloma is the second most common haematological malignancy in the U.S. (after non - Hodgkin lymphoma, constitutes 1% of all cancers and constitutes 2% of all cancer deaths. Cutaneous involvement of multiple myeloma during treatment period is uncommon with fewer described in literature. Moreover, metastatic cutaneous involvement at the sole of the foot during treatment period of a IgA kappa type multiple myeloma patient followed by death has not encountered in literature. We have reported such a case

Osteosclerotic Myeloma with Peripheral Neuropathy

African Journals Online (AJOL)

diagnosis of myeloma should, in future, be suspected in these circumstances. ... moved towards the midline, and involved the lower thoracic region of his back for 18 .... further treatment, took his own discharge and has been lost to follow-up.

Contestation, contingency, and justice in the Nordic low-carbon energy transition

International Nuclear Information System (INIS)

Sovacool, Benjamin K.

2017-01-01

The five Nordic countries have aggressive climate and energy policies in place and have already emerged to be leaders in renewable energy and energy efficiency. Denmark is renowned for its pioneering use of wind energy, Finland and Sweden bioenergy, Norway hydroelectricity and Iceland geothermal energy. All countries aim to be virtually “fossil free” by 2050. This study explores the Nordic energy transition through the lens of three interconnected research questions: How are they doing it? What challenges exist? And what broader lessons result for energy policy? The study firstly investigates the pathways necessary for these five countries to achieve their low-carbon goals. It argues that a concerted effort must be made to (1) promote decentralized and renewable forms of electricity supply; (2) shift to more sustainable forms of transport; (3) further improve the energy efficiency of residential and commercial buildings; and (4) adopt carbon capture and storage technologies for industry. However, the section that follows emphasizes some of the empirical barriers the Nordic transition must confront, namely political contestation, technological contingency, and social justice and recognition concerns. The study concludes with implications for what such historical progress, and future transition pathways, mean for both energy researchers and energy planners. - Highlights: • Nordic countries have strong energy and climate policies to be practically “fossil free” by 2050. • Decarbonization and transition pathways depend on renewable energy, efficiency, transport, and industry. • The Nordic transition remains contingent on further technological innovations and policy commitments. • It also raises energy justice issues concerning employment, public knowledge, and embodied emissions.

Association between diffuse idiopathic skeletal hyperostosis and multiple myeloma

International Nuclear Information System (INIS)

Scutellari, P.N.; Orzincolo, C.D.; Castaldi, G.

1995-01-01

Radiologic studies were performed over a 26-month period in a series of 97 consecutive patients with multiple myeloma (56 male and 41 female, aged 42-91 years). Both myelomatous bone lesions and hyperostosis similar to DISH were found in these patients. The prevalence of DISH in association with multiple myeloma (21 male and 8 females patients) was higher (29.8%) than in our control group (973 patients, 449 male and 524 female) or in the general population (15-20%). The involved segments of the column were thoracic in 11 males and 7 females, cervical in 8 males and 2 females, and lumbar in 5 males and 4 females. Ossifying enthesopathy in the pelvis (''whiskering'') was observed in 7 males and 1 female. (orig./MG)

Association between diffuse idiopathic skeletal hyperostosis and multiple myeloma

Energy Technology Data Exchange (ETDEWEB)

Scutellari, P.N. [Inst. of Radiology, Ferrara Univ. School of Medicine (Italy); Orzincolo, C.D. [Dept. of Radiology, St. Anna Hospital, Ferrara (Italy); Castaldi, G. [Dept. of Medicine, St. Maria delle Croci Hospital, Ravenna (Italy)

1995-10-01

Radiologic studies were performed over a 26-month period in a series of 97 consecutive patients with multiple myeloma (56 male and 41 female, aged 42-91 years). Both myelomatous bone lesions and hyperostosis similar to DISH were found in these patients. The prevalence of DISH in association with multiple myeloma (21 male and 8 females patients) was higher (29.8%) than in our control group (973 patients, 449 male and 524 female) or in the general population (15-20%). The involved segments of the column were thoracic in 11 males and 7 females, cervical in 8 males and 2 females, and lumbar in 5 males and 4 females. Ossifying enthesopathy in the pelvis (``whiskering``) was observed in 7 males and 1 female. (orig./MG)

Parents' labour market participation as a predictor of children's health and wellbeing: a comparative study in five Nordic countries.

Science.gov (United States)

Reinhardt Pedersen, C; Madsen, M

2002-11-01

To study the association between parents' labour market participation and children's health and wellbeing. Parent reported data on health and wellbeing among their children from the survey Health and welfare among children and adolescents in the Nordic countries, 1996. A cross sectional study of random samples of children and their families in five Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden). A total of 10 317 children aged 2-17 years. Children in families with no parents employed in the past six months had higher prevalence of recurrent psychosomatic symptoms (odds ratio 1.67, 95% confidence intervals 1.16 to 2.40), chronic illness (odds ratio 1.35, 95% confidence intervals 1.00 to 1.84), and low wellbeing (odds ratio 1.47, 95% confidence intervals 1.12 to 1.94). Social class, family type, parents' immigrant status, gender and age of the child, respondent, and country were included as confounders. When social class, family type and the parents' immigrant status (one or more born in the Nordic country versus both born elsewhere) were introduced into the model, the odds ratios were reduced but were still statistically significant. Health outcomes and parents' labour market participation were associated in all five countries. Children in families with no parents employed in the past six months had higher prevalence of ill health and low wellbeing in the five Nordic countries despite differences in employment rates and social benefits.

Pharmacoepidemiology at Nordic School of Public Health NHV: Examples from 1999 to 2014.

Science.gov (United States)

Stålsby Lundborg, Cecilia; Gyllensten, Hanna; Hedna, Khedidja; Hakkarainen, Katja M; Lesén, Eva; Andersson Sundell, Karolina; Gyllensten, H; Hedna, K; Hakkarainen, K M; Lesén, E; Sundell, K Andersson

2015-08-01

Pharmacoepidemiology is a branch of public health and had a place at the Nordic School of Public Health. Courses, Master's theses and Doctorates of Public Health (DrPH) in Pharmacoepidemiology were a relatively minor, but still important part of the school's activities. This paper gives a short background, followed by some snapshots of the activities at NHV, and then some illustrative case-studies. These case-studies list their own responsible co-authors and have separate reference lists. In the Nordic context, NHV was a unique provider of training and research in pharmacoepidemiology, with single courses to complete DrPH training, as well as implementation of externally-funded research projects. With the closure of NHV at the end of 2014, it is unclear if such a comprehensive approach towards pharmacoepidemiology will be found elsewhere in the Nordic countries. © 2015 the Nordic Societies of Public Health.

Top Information Need Priorities of Older Adults Newly Diagnosed With Active Myeloma.

Science.gov (United States)

Tariman, Joseph D; Doorenbos, Ardith; Schepp, Karen G; Singhal, Seema; Berry, Donna L

2015-01-01

Prioritizing patients' information needs maximizes efficiency. This study examined the information sources and priorities in a sample of older adults newly diagnosed with symptomatic myeloma requiring immediate therapy. An association analysis of whether information needs were influenced by sociodemographic variables such as age, gender, education, marital status, and income was also conducted. The Information Needs Questionnaire (INQ) and an investigator-developed interview schedule were administered to 20 older adults diagnosed with symptomatic myeloma during a 30- to 45-minute semistructured interview. We found that older adults newly diagnosed with symptomatic myeloma have different priorities of information needs when compared with younger patients diagnosed with various types of cancer. The top three priorities related to treatment, prognosis, and self-care. Sociodemographic variables did not influence the priorities of information needs among older adults with symptomatic myeloma. The Internet, physicians, family, and friends were among the top sources of information. Advanced practitioners in oncology should support and identify interventions that can enhance patients' learning process from these sources. Well poised to assist patients in searching credible and reliable Internet sources, advanced practitioners in oncology can provide patient education about different treatments and the impact of such treatments on prognosis (e.g., overall survival and likelihood of cure).

Monocyte/macrophage-derived soluble CD163: A novel biomarker in multiple myeloma

DEFF Research Database (Denmark)

Andersen, Morten Nørgaard; Abildgaard, Niels; Maniecki, Maciej B

2014-01-01

fluids (soluble CD163, sCD163). In this study, we examined serum sCD163 as a biomarker in patients with newly diagnosed multiple myeloma. METHODS: Peripheral blood (n = 104) and bone marrow (n = 17) levels of sCD163 were measured using an enzyme-linked immunosorbent assay. RESULTS: At diagnosis, high s......CD163 was associated with higher stage according to the International Staging System (ISS) and with other known prognostic factors in multiple myeloma (creatinine, C-reactive protein, and beta-2 microglobulin). Soluble CD163 decreased upon high-dose treatment, and in a multivariate survival analysis...... in bone marrow samples than in the matched blood samples, which indicate a localized production of sCD163 within the bone marrow microenvironment. CONCLUSIONS: Soluble CD163 was found to be a prognostic marker in patients with multiple myeloma. This may indicate that macrophages and/or monocytes have...

The European internal market and Nordic energy policy

International Nuclear Information System (INIS)

Grohnheit, P.E.; Hoier Nielsen, H.; Soerensen, H.

1992-01-01

The aim was to attempt to clarify the immediate consequences, and potentials for energy policy, for the authorities and supply companies in the Nordic countries in relation to the establishment of the Single Market. Potentials for the development of coordinated electricity supply and natural gas markets, and for cooperative Nordic research and initiatives are examined. Descriptions of conditions in other lands are given. It is stated that decisions on investments must now be taken within an open capital market with other traditions. There is a need for faster technology transfer. It is concluded that it will be difficult to develope trade related to natural gas between all the Nordic countries, but it should increase (also with regard to electricity) between the Nordic countries and their neighbour countries. Regarding electricity supply, lifting of existing rights of monopoly will result in weaker connections between producer and consumer and supply reliability will decrease. Natural gas supply reliability will be strengthened but producers will shoulder more market risks. Fusions will increase but a greater variation of company types and organization forms will develope. Competition will be sharper and prices for electric power could rise. Nordic energy policy will have a more international character, especially with regard to environmental protection. Long-term investment will be encouraged. The Nordic Council of Ministers will need to concentrate on information dissemination related to energy system analyses as a basis for decision-making. Export of Scandinavian hydroelectric power will contribute to international goals for environmental protection. (AB) (45 refs.)

The challenges of military medical education and training for physicians and nurses in the Nordic countries - an interview study.

Science.gov (United States)

Sonesson, Linda; Boffard, Kenneth; Lundberg, Lars; Rydmark, Martin; Karlgren, Klas

2017-04-11

Development and use of e-learning has not taken place to the same extent in military medicine in the Nordic countries. The aim was to explore the similarities and differences in education and training in military medicine for health professionals in the Nordic countries, and more specifically to identify the specific challenges regarding education and training of military medicine, and how e-learning is used at present and the opportunities for the future. Key educators within military medicine in the Nordic countries, as approved by the respective Surgeons General, were interviewed and the interviews were analyzed using content analysis. The data showed that all Nordic countries cooperate in the field of military medical training to some extent. The models of recruitment and employment of health professionals differed as well as the degree of political support. These differences affected the ability for health professionals to gain actual experience from the military environment. To improve the quality of medical education and training, attempts were made to recruit physicians. The recruitment of physicians was considered a challenge which had resulted in disruptions of courses, training programs and maintenance of accreditation. The Nordic countries were described as having commonalities in the military medical systems and common needs for international collaboration within training, but differing in the range of education and training. Gaps were identified in methods for transferring outcomes from education into practice, as well as regarding evaluation and feedback of outcomes to military medicine. The educational tradition was described as oriented towards practical skills training without requirements on pedagogical education of educators. The results confirmed previous studies showing that e-learning was underutilized. Contextual understanding and experience of healthcare were seen as crucial factors for successful e-learning development. Extended Nordic

Development of a Common Nordic Balance Settlement

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-02-15

NordREG finds it essential for the customers that a common integrated end-user electricity market is developed and that all end-users are able to take part in the Nordic market. A common Nordic balance settlement is one important part of such a change. However, attention has to be paid to the comments that a badly designed common system is worse than well-designed national systems. It is thus important that the change to a common balance settlement is so thoroughly investigated that the common system gives a basis for a well-functioning market. An important basis for such a change is an agreed vision for the process: The present different systems for balance settlement shall by the year 2010 be replaced by a common Nordic balance settlement. This means that: It will be possible for a supplier to sell to the whole Nordic market from one legal entity and using only one system for customer management and reporting. The common Nordic balance settlement will be designed in such a way that it contributes to a well functioning market. This means for example that it will be attractive even for small suppliers and some end-users to be balance responsible parties. It is feasible that the first phase is focused on those present differences that are most decisive for fulfilment of the vision. NordREG recommends that the following issues shall be discussed and agreed in co-operation between NordREG, Nordel and relevant stakeholders in the first phase: The definition shall include how the common Nordic balance settlement shall interact with the balance control and the balance regulation of the interconnected power system and the balance settlement between countries performed by the TSOs. The definition should include the cost-base for common Nordic balance settlement in relation to other system responsibility costs. The core activities of system responsibility have also been analyzed by NordREG. It is important to find a balance between inter alia the need for simplicity and the

Development of a Common Nordic Balance Settlement

International Nuclear Information System (INIS)

2006-02-01

NordREG finds it essential for the customers that a common integrated end-user electricity market is developed and that all end-users are able to take part in the Nordic market. A common Nordic balance settlement is one important part of such a change. However, attention has to be paid to the comments that a badly designed common system is worse than well-designed national systems. It is thus important that the change to a common balance settlement is so thoroughly investigated that the common system gives a basis for a well-functioning market. An important basis for such a change is an agreed vision for the process: The present different systems for balance settlement shall by the year 2010 be replaced by a common Nordic balance settlement. This means that: It will be possible for a supplier to sell to the whole Nordic market from one legal entity and using only one system for customer management and reporting. The common Nordic balance settlement will be designed in such a way that it contributes to a well functioning market. This means for example that it will be attractive even for small suppliers and some end-users to be balance responsible parties. It is feasible that the first phase is focused on those present differences that are most decisive for fulfilment of the vision. NordREG recommends that the following issues shall be discussed and agreed in co-operation between NordREG, Nordel and relevant stakeholders in the first phase: The definition shall include how the common Nordic balance settlement shall interact with the balance control and the balance regulation of the interconnected power system and the balance settlement between countries performed by the TSOs. The definition should include the cost-base for common Nordic balance settlement in relation to other system responsibility costs. The core activities of system responsibility have also been analyzed by NordREG. It is important to find a balance between inter alia the need for simplicity and the

Walking on four limbs: A systematic review of Nordic Walking in Parkinson disease.

Science.gov (United States)

Bombieri, Federica; Schena, Federico; Pellegrini, Barbara; Barone, Paolo; Tinazzi, Michele; Erro, Roberto

2017-05-01

Nordic Walking is a relatively high intensity activity that is becoming increasingly popular. It involves marching using poles adapted from cross-country skiing poles in order to activate upper body muscles that would not be used during normal walking. Several studies have been performed using this technique in Parkinson disease patients with contradictory results. Thus, we reviewed here all studies using this technique in Parkinson disease patients and further performed a meta-analysis of RCTs where Nordic Walking was evaluated against standard medical care or other types of physical exercise. Nine studies including four RCTs were reviewed for a total of 127 patients who were assigned to the Nordic Walking program. The majority of studies reported beneficial effects of Nordic Walking on either motor or non-motor variables, but many limitations were observed that hamper drawing definitive conclusions and it is largely unclear whether the benefits persist over time. It would appear that little baseline disability is the strongest predictor of response. The meta-analysis of the 4 RCTs yielded a statistically significant reduction of the UPDRS-3 score, but its value of less than 1 point does not appear to be clinically meaningful. Well-designed, large RCTs should be performed both against standard medical care and other types of physical exercise to definitively address whether Nordic Walking can be beneficial in PD. Copyright © 2017. Published by Elsevier Ltd.

Policies and Initiatives for Carbon Neutrality in Nordic

DEFF Research Database (Denmark)

Wu, Qiuwei; Møller, Jakob Glarbo; Østergaard, Jacob

2013-01-01

Policies and initiatives promoting carbon neutrality in the Nordic heating and transport systems are presented. The focus within heating systems is the promotion of HPs (heat pumps) while the focus within transport systems is initiatives regarding EVs (electric vehicles). It is found...... for the future heating and transport systems with the ambition of realizing carbon neutrality...... that the conversion to HPs in the Nordic region relies on both private economic and national economic incentives. Initiatives toward carbon neutrality in the transport system are mostly concentrated on research, development and demonstration for deployment of a large number of EVs. All Nordic countries have plans...

The shaping and functional consequences of the dosage effect landscape in multiple myeloma.

Science.gov (United States)

Samur, Mehmet K; Shah, Parantu K; Wang, Xujun; Minvielle, Stéphane; Magrangeas, Florence; Avet-Loiseau, Hervé; Munshi, Nikhil C; Li, Cheng

2013-10-02

Multiple myeloma (MM) is a malignant proliferation of plasma B cells. Based on recurrent aneuploidy such as copy number alterations (CNAs), myeloma is divided into two subtypes with different CNA patterns and patient survival outcomes. How aneuploidy events arise, and whether they contribute to cancer cell evolution are actively studied. The large amount of transcriptomic changes resultant of CNAs (dosage effect) pose big challenges for identifying functional consequences of CNAs in myeloma in terms of specific driver genes and pathways. In this study, we hypothesize that gene-wise dosage effect varies as a result from complex regulatory networks that translate the impact of CNAs to gene expression, and studying this variation can provide insights into functional effects of CNAs. We propose gene-wise dosage effect score and genome-wide karyotype plot as tools to measure and visualize concordant copy number and expression changes across cancer samples. We find that dosage effect in myeloma is widespread yet variable, and it is correlated with gene expression level and CNA frequencies in different chromosomes. Our analysis suggests that despite the enrichment of differentially expressed genes between hyperdiploid MM and non-hyperdiploid MM in the trisomy chromosomes, the chromosomal proportion of dosage sensitive genes is higher in the non-trisomy chromosomes. Dosage-sensitive genes are enriched by genes with protein translation and localization functions, and dosage resistant genes are enriched by apoptosis genes. These results point to future studies on differential dosage sensitivity and resistance of pro- and anti-proliferation pathways and their variation across patients as therapeutic targets and prognosis markers. Our findings support the hypothesis that recurrent CNAs in myeloma are selected by their functional consequences. The novel dosage effect score defined in this work will facilitate integration of copy number and expression data for identifying driver

Zingiber officinale, Piper retrofractum and Combination Induced Apoptosis and p53 Expression in Myeloma and WiDr Cell Lines

Directory of Open Access Journals (Sweden)

HENY EKOWATI

2012-09-01

Full Text Available In previous studies, Zingiber officinale, Piper retrofractum, and the combination showed cytotoxic activity, induced apoptosis, and p53 expression of HeLa, T47D, and MCF-7 cell lines. This study was conducted to investigate the cytotoxic and apoptotic activity of Zingiber officinale (ZO, Piper retrofractum (PR, and the combination as well as their effect to p53 expression on Myeloma and WiDr cells. The powder of ZO, PR, and ZO + PR combination (1:1 were macerated with 96% ethanol for 3 x 24 hours. MTT cytotoxic assay was performed on Myeloma and WiDr cell lines. Apoptotic cells were stained with ethidium bromide and acridine orange. Imunohistochemical expression of p53 was examined on Myeloma and WiDr cell lines. Doxorubicin was used as positive control in all assays. Results showed that ZO, PR, and ZO + PR combination had cytotoxic activity on Myeloma cells with IC50 of 28, 36, and 55 mg/ml respectively and WiDr cell lines with IC50 of 74, 158, and 64 mg/ml respectively, induced apoptotic activity, and increased p53 expression on Myeloma and WiDr cells. These results suggest that ZO, PR, and their combination induced Myeloma and WiDr cells in apoptosis through p53 expression.

Workshop on assessments of National Carbon Budgets within the Nordic Region

DEFF Research Database (Denmark)

Hansen, Kristina; Koyama, Aki; Lansø, Anne Sofie

The three-day workshop organized by the three Nordic research projects; ECOCLIM, LAGGE and SnowCarbo brought together scientists and other actors from Nordic countries to communicate and discuss research on carbon budget estimations in the Nordic region. Through presentations of most recent...... research in the field and following scientific discussions, the workshop contributed to strengthen the scientific basis of the identification and quantification of major natural carbon sinks in the Nordic region on which integrated climate change abatement and management strategies and policy decisions...... status and knowledge on research on assessments of national carbon budgets as well as on projections and sensitivity to future changes in e.g. management and climate change in the Nordic Region....

Workshop on assessments of National Carbon Budgets within the Nordic Region

DEFF Research Database (Denmark)

Mørk, Eva Thorborg; Lansø, Anne Sofie; Hansen, Kristina

2013-01-01

The three-day workshop organized by the three Nordic research projects; ECOCLIM, LAGGE and SnowCarbo brought together scientists and other actors from Nordic countries to communicate and discuss research on carbon budget estimations in the Nordic region. Through presentations of most recent...... research in the field and following scientific discussions, the workshop contributed to strengthen the scientific basis of the identification and quantification of major natural carbon sinks in the Nordic region on which integrated climate change abatement and management strategies and policy decisions...... status and knowledge on research on assessments of national carbon budgets as well as on projections and sensitivity to future changes in e.g. management and climate change in the Nordic Region....

Economic poverty among children and adolescents in the Nordic countries

DEFF Research Database (Denmark)

Povlsen, Lene; Regber, Susann; Fosse, Elisabeth

2018-01-01

Aims: This study aimed to identify applied definitions and measurements of economic poverty and to explore the proportions and characteristics of children and adolescents living in economic poverty in Denmark, Finland, Iceland, Norway and Sweden during the last decade and to compare various...... statistics between the Nordic countries. Methods: Official data from central national authorities on statistics, national reports and European Union Statistics of income and living conditions data were collected and analysed during 2015–2016. Results: The proportion of Nordic children living in economic...... poverty in 2014 ranged from 9.4% in Norway to 18.5% in Sweden. Compared with the European Union average, from 2004 to 2014 Nordic families with dependent children experienced fewer difficulties in making their money last, even though Icelandic families reported considerable difficulties...

Experiences from Nordic research collaboration in linguistics

Directory of Open Access Journals (Sweden)

Helge Sandøy

2007-04-01

Full Text Available The project “Modern loanwords in the languages of the Nordic countries (MIN – Moderne importord i språka i Norden” was the first large-scale collaborative project between linguists in the Nordic countries. This article presents both the aim of the project and some experiences from the work with respect to project design, financing and networking.

Monoclonal antibodies in myeloma

DEFF Research Database (Denmark)

Sondergeld, P.; van de Donk, N. W. C. J.; Richardson, P. G.

2015-01-01

The development of monoclonal antibodies (mAbs) for the treatment of disease goes back to the vision of Paul Ehrlich in the late 19th century; however, the first successful treatment with a mAb was not until 1982, in a lymphoma patient. In multiple myeloma, mAbs are a very recent and exciting add...

Struggling bodies and body struggles: explorations of body and religion in contemporary Nordic film

Directory of Open Access Journals (Sweden)

Sofia Sjö

2011-01-01

Full Text Available This study focuses on representations of the body and religion in Nordic film. The aim is to illustrate the kinds of representations of religion and the body that can be found in contemporary Nordic films, demonstrate how these representations relate to religion, the body and film more generally, and explore what perceptions of and attitudes to the body and religion the representations suggest. The analysis begins with an introduction to religion and film studies, religion in Nordic film and the themes and films chosen for this study. After this a short overview of earlier studies dealing with the body, film, and religion is presented, before delving into the issue of the body and religion in Nordic film. The article is concluded by reflecting on the more over-arching ideas and attitudes that the material can be argued to point to and the possible changes and challenges the films express.

Radiological diagnostics of multiple myeloma; Radiologische Diagnostik des multiplen Myeloms

Energy Technology Data Exchange (ETDEWEB)

D' Anastasi, M.; Grandl, S.; Reiser, M.F.; Baur-Melnyk, A. [Klinikum der Ludwig-Maximilians-Universitaet Muenchen, Campus Grosshadern, Institut fuer Klinische Radiologie, Muenchen (Germany)

2014-06-15

Robust and reliable imaging methods are required to estimate the skeletal tumor load in multiple myeloma, as well as for the diagnosis of extraskeletal manifestations. Imaging also plays an essential role in the assessment of fracture risk and of vertebral fractures. The conventional skeletal survey has been the gold standard in the imaging of multiple myeloma for many years. Other modalities which have been investigated and are in use are whole-body computed tomography (WBCT), 18F-fluorodeoxyglucose positron emission tomography computed tomography (FDG PET-CT) and whole-body magnetic resonance imaging (WBMRI). These techniques are able to depict both mineralized bone and the bone marrow with a high sensitivity for myeloma lesions. Several studies have shown that cross-sectional imaging is superior to the skeletal survey in the detection of myeloma lesions and WBMRI has been shown to be significantly more sensitive than WBCT for the detection of focal myeloma lesions as well as for diffuse infiltration. The FDG PET-CT technique has a sensitivity comparable to WBMRI. Due to the higher sensitivity in the detection of myeloma lesions WBCT and WBMRI should replace the skeletal survey. A WBCT should be performed if there is suspicion of multiple myeloma. If no focal lesions are found WBMRI or at least MRI of the spine and pelvis should be additionally performed if available. If WBMRI has been initially performed and focal lesions are present, an additional WBCT may be performed to assess the extent of bone destruction and fracture risk. In cases of monoclonal gammopathy of undetermined significance (MGUS), solitary and smoldering myeloma, a WBMRI, if available, should be performed in addition to WBCT. (orig.) [German] Die Aufgabe der bildgebenden Diagnostik beim multiplen Myelom (MM) ist die zuverlaessige Erfassung der Tumorlast im Skelett sowie auch der extraskelettalen Manifestationen und der assoziierten Komplikationen (z. B. Wirbelkoerperfrakturen, Frakturgefahr

Wind and load variability in the Nordic countries

Energy Technology Data Exchange (ETDEWEB)

Holttinen, H.; Rissanen, S. [VTT Technical Research Centre of Finland, Espoo (Finland); Larsen, X. [Danmarks Tekniske Universitet, Lyngby (Denmark); Loevholm, A. L. [Kjeller Vindteknikk (Norway)

2013-04-15

This publication analysed the variability of wind production and load in Denmark, Finland, Sweden, and the Nordic region as a whole, based on real data measured from large-scale wind power during 2009-2011. The Nordic-wide wind power time series was scaled up such that Sweden had same amount of wind power production than Denmark, and Finland and Norway only 50% of the wind power production in Denmark. Wind power production in Denmark and Sweden is somewhat correlated (coefficient 0.7) but less correlation is found between the other countries. The variations from one hour to the next are only weakly correlated between all countries, even between Denmark and Sweden. Largest variations occur when the production is approximately 30-70% of installed capacity and variability is low during periods of light winds. The variability in shorter time scales was less than the hourly variations. During the three years analysed in this publication there were few storm incidents and they did not produce dramatic wind power ramps in the Nordic region. Wind and load variations are not correlated between the countries, which is beneficial from the viewpoint of wind integration. The smoothing effect is shown as reduction of variability from a single country to Nordic-wide wind power. The impact of wind power on the variability that the system experiences is evaluated by analysing the variability of net load with different wind power penetration levels. The Nordic-wide wind power production increases the highest hourly ramps by 2.4% (up) and -3.6% (down) of installed wind power capacity when there is 20% wind power penetration and by 2.7% (up) and -4.7% (down) for 30% wind penetration. These results assess the impacts of variability only. The next step will be assessing the uncertainty from forecast errors. The timing of ramp events, and occurrence of high-wind and low-load are studied. With current wind penetration, low production levels (2-5% of installed wind power) can occur in a

The Nordic electricity market towards 2010

International Nuclear Information System (INIS)

Aune, Finn Roar; Johnsen, Tor Arnt

2001-01-01

This article opens by examining the development of the Nordic power market in the 1990s. It tries to establish that the power market is a complex one. The market conditions vary greatly from one region to another and over time, and there is varying degree of integration among the regional markets. Thus, analyses of policy and political measures must be based on a detailed computational tool. In the SAMRAM project ''Power trade and Transmission'', such a computational model has been established, Normod-T. The article describes the principle features of the model and uses it to study the development of the Nordic power market toward the year 2010. It further analyses the impact of building gas power plants in Norway and of establishing a new cable for transmission of electric power between Norway and Germany

RECENT ADVANCES IN PATHO-BIOLOGY OF MYELOMA BONE DISEASE: CLINICOPATHOLOGY AND LITERATURE OF REVIEW

Directory of Open Access Journals (Sweden)

Lohit Kumar

2016-03-01

Full Text Available Bone disease is a hallmark of multiple myeloma, presenting as lytic lesions associated with bone pain, pathological fractures requiring surgery and/or radiation to bone, spinal cord compression and hypercalcaemia. Increased osteoclastic activity unaccompanied by a compensatory increase in osteoblast function, leading to enhanced bone resorption results in bone disease. The interaction of plasma cells with the bone marrow microenvironment has been shown to play a vital role. Also, interactions of myeloma cells with osteoclasts enhance myeloma growth and survival, and thereby create a vicious cycle leading to extensive bone destruction and myeloma cell expansion.

Emerging therapies in multiple myeloma.

Science.gov (United States)

El-Amm, Joelle; Tabbara, Imad A

2015-06-01

The treatment of multiple myeloma has evolved significantly over the past 2 decades due to the use of high-dose chemotherapy and autologous stem cell transplantation, and the subsequent introduction of the immunomodulatory agents (thalidomide and lenalidomide) and the proteasome inhibitor (bortezomib). The median overall survival of multiple myeloma patients has increased significantly with patients younger than age 50 years experiencing a 10-year survival rate of around 40%. However, despite the increased effectiveness of the first-line agents, the majority of patients will eventually relapse and become drug resistant. Promising novel therapies have recently emerged and are being used to treat relapsed and refractory patients. This review will cover the clinical data regarding these emergent therapies that include new generation of proteasome inhibitors (carfilzomib, ixazomib, oprozomib, and marizomib), immunomodulatory drugs (pomalidomide), monoclonal antibodies (elotuzumab and daratumumab), signal transduction modulator (perifosine), and histone deacetylase inhibitors (vorinostat and panobinostat).

The Nordic Seas carbon budget: Sources, sinks, and uncertainties

OpenAIRE

Jeansson, Emil; Olsen, Are; Eldevik, Tor; Skjelvan, Ingunn; Omar, Abdirahman M.; Lauvset, Siv K.; Nilsen, Jan Even Ø.; Bellerby, Richard G. J; Johannessen, Truls; Falck, Eva

2011-01-01

A carbon budget for the Nordic Seas is derived by combining recent inorganic carbon data from the CARINA database with relevant volume transports. Values of organic carbon in the Nordic Seas' water masses, the amount of carbon input from river runoff, and the removal through sediment burial are taken from the literature. The largest source of carbon to the Nordic Seas is the Atlantic Water that enters the area across the Greenland-Scotland Ridge; this is in particular true for the anthropogen...

H{sub 2} R and D activities in the Nordic Countries

Energy Technology Data Exchange (ETDEWEB)

Holst Joergensen, B.

2003-10-01

The report describes hydrogen related R and D activities in the five Nordic countries from 1998 and onwards. It is not a comprehensive account of all hydrogen related R and D as much relevant research is not described under the heading of hydrogen energy but integrated in other programmes or part of more generic basic research. Also much industry conducted H2 R and D activities are not published. It gives some background information on R and D in the five Nordic countries and gives account of the R and D efforts. At Nordic level through the Nordic Energy Research a number of R and D projects are also conducted and shortly described. At EU level, Nordic stakeholders are represented in a number of hydrogen and fuel cell R and D projects and short descriptions are provided. In the appendix, more detaield informaiton is given on the R and D projects at national, EU and Nordic levels. (au)

Pulmonary Embolism as the First Manifestation of Multiple Myeloma

Directory of Open Access Journals (Sweden)

N. Vallianou

2013-01-01

Full Text Available Multiple myeloma is considered a hypercoagulable state due to several mechanisms such as the increased IL-6 and immunoglobulins production, the defective fibrinolytic mechanism, and the acquired resistance to activated protein C that are involved in the pathogenesis and clinical futures of the disease. We describe a case of a female patient who presented to the hospital with pulmonary embolism as the first manifestation of the hypercoagulability of multiple myeloma.

Primary laryngeal localization of multiple myeloma: A case report

OpenAIRE

Allegra, Eugenia; Marino, Nicol?; Modica, Domenico; Emmanuele, Carmela; Saita, Vincenzo

2017-01-01

Multiple myeloma is a lymphoproliferative disease that may involve the bone marrow as well as extramedullary soft tissues. However, laryngeal localization of multiple myeloma is extremely rare. We herein present the case of a 68-year-old male patient with a history of dyspnea, dysphonia and dysphagia. Laryngoscopic examination revealed a lesion involving the right glottis and right vestibular (false) vocal fold, with absence of ipsilateral laryngeal motility and constriction of the airway. Co...

Occupational Science in a Nordic perspective

DEFF Research Database (Denmark)

Borg, Tove; Bendixen, HJ; Frydendal, E

The book is anthology and the first of its kind to be publiched in the Nordic countries. It comprices contributions from Sweden, Norway and Denmark. The authors write from respective fields of interest, research perspectives and personal experiences. The overall goal is to present a vision and im...... and importance of Occupational Science in a Nordic perspective, in responce to the American understanding. The anthology comprise 14 articles and adresses all with an interest in research in human activity and social participation....

Transcatheter shunt embolotherapy in multiple myeloma with high output heart failure

Energy Technology Data Exchange (ETDEWEB)

Kim, Jeong Ho [Wonkwang University School of Medicine, Iksan (Korea, Republic of); Ko, Gi Young; Yoon, Hyun Ki; Sung, Kyu Bo [Ulsan University College of Medicine, Seoul (Korea, Republic of)

2002-12-01

High-output heart failure may be fairly common in patients with multiple myeloma and is associated with severe bone involvement. In this report, we describe the case of a 67-year-old man with multiple myeloma who presented with high output heart failure subsequently treated by transcatheter arterial embolization.

Transcatheter shunt embolotherapy in multiple myeloma with high output heart failure

International Nuclear Information System (INIS)

Kim, Jeong Ho; Ko, Gi Young; Yoon, Hyun Ki; Sung, Kyu Bo

2002-01-01

High-output heart failure may be fairly common in patients with multiple myeloma and is associated with severe bone involvement. In this report, we describe the case of a 67-year-old man with multiple myeloma who presented with high output heart failure subsequently treated by transcatheter arterial embolization

Establishment of a murine graft-versus-myeloma model using allogeneic stem cell transplantation.

Directory of Open Access Journals (Sweden)

Marilène Binsfeld

Full Text Available Multiple myeloma (MM is a malignant plasma cell disorder with poor long-term survival and high recurrence rates. Despite evidence of graft-versus-myeloma (GvM effects, the use of allogeneic hematopoietic stem cell transplantation (allo-SCT remains controversial in MM. In the current study, we investigated the anti-myeloma effects of allo-SCT from B10.D2 mice into MHC-matched myeloma-bearing Balb/cJ mice, with concomitant development of chronic graft-versus-host disease (GvHD.Balb/cJ mice were injected intravenously with luciferase-transfected MOPC315.BM cells, and received an allogeneic (B10.D2 donor or autologous (Balb/cJ donor transplant 30 days later. We observed a GvM effect in 94% of the allogeneic transplanted mice, as the luciferase signal completely disappeared after transplantation, whereas all the autologous transplanted mice showed myeloma progression. Lower serum paraprotein levels and lower myeloma infiltration in bone marrow and spleen in the allogeneic setting confirmed the observed GvM effect. In addition, the treated mice also displayed chronic GvHD symptoms. In vivo and in vitro data suggested the involvement of effector memory CD4 and CD8 T cells associated with the GvM response. The essential role of CD8 T cells was demonstrated in vivo where CD8 T-cell depletion of the graft resulted in reduced GvM effects. Finally, TCR Vβ spectratyping analysis identified Vβ families within CD4 and CD8 T cells, which were associated with both GvM effects and GvHD, whereas other Vβ families within CD4 T cells were associated exclusively with either GvM or GvHD responses.We successfully established an immunocompetent murine model of graft-versus-myeloma. This is the first murine GvM model using immunocompetent mice that develop MM which closely resembles human MM disease and that are treated after disease establishment with an allo-SCT. Importantly, using TCR Vβ spectratyping, we also demonstrated the presence of GvM unique responses

Influence of Disease and Patient Characteristics on Daratumumab Exposure and Clinical Outcomes in Relapsed or Refractory Multiple Myeloma

DEFF Research Database (Denmark)

Yan, Xiaoyu; Clemens, Pamela L; Puchalski, Thomas

2018-01-01

OBJECTIVE: The aim of this study was to understand the influence of disease and patient characteristics on exposure to daratumumab, an immunoglobulin Gκ (IgGκ) monoclonal antibody, and clinical outcomes in relapsed or refractory multiple myeloma (MM). PATIENTS AND METHODS: Baseline myeloma type, ...

Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation

DEFF Research Database (Denmark)

Boissy, Patrice; Andersen, Thomas L; Abdallah, Basem M

2005-01-01

, a challenge for treating multiple myeloma is discovering drugs targeting not only myeloma cells but also osteoclasts and osteoblasts. Because resveratrol (trans-3,4',5-trihydroxystilbene) is reported to display antitumor activities on a variety of human cancer cells, we investigated the effects...... of this natural compound on myeloma and bone cells. We found that resveratrol reduces dose-dependently the growth of myeloma cell lines (RPMI 8226 and OPM-2) by a mechanism involving cell apoptosis. In cultures of human primary monocytes, resveratrol inhibits dose-dependently receptor activator of nuclear factor......RNA and cell surface protein levels and a decrease of NFATc1 stimulation and NF-kappaB nuclear translocation, whereas the gene expression of c-fms, CD14, and CD11a is up-regulated. Finally, resveratrol promotes dose-dependently the expression of osteoblast markers like osteocalcin and osteopontin in human bone...

Effects of school meals based on the New Nordic Diet on intake of signature foods: a randomised controlled trial. The OPUS School Meal Study

DEFF Research Database (Denmark)

Andersen, Rikke; Biltoft-Jensen, Anja Pia; Andersen, Elisabeth Wreford

2015-01-01

A New Nordic Diet (NND) was developed in the context of the Danish OPUS Study (Optimal well-being, development and health for Danish children through a healthy New Nordic Diet). Health, gastronomic potential, sustainability and Nordic identity were crucial principles of the NND. The aim......) in random order. The entire diet was recorded over 7 consecutive days using a validated Web-based Dietary Assessment Software for Children. The NND resulted in higher intakes during the entire week (% increase) of root vegetables (116 (95 % CI 1.93, 2.42)), cabbage (26 (95 % CI 1.08, 1.47)), legumes (22 (95...

Management of relapsed multiple myeloma: recommendations of the International Myeloma Working Group.

Science.gov (United States)

Laubach, J; Garderet, L; Mahindra, A; Gahrton, G; Caers, J; Sezer, O; Voorhees, P; Leleu, X; Johnsen, H E; Streetly, M; Jurczyszyn, A; Ludwig, H; Mellqvist, U-H; Chng, W-J; Pilarski, L; Einsele, H; Hou, J; Turesson, I; Zamagni, E; Chim, C S; Mazumder, A; Westin, J; Lu, J; Reiman, T; Kristinsson, S; Joshua, D; Roussel, M; O'Gorman, P; Terpos, E; McCarthy, P; Dimopoulos, M; Moreau, P; Orlowski, R Z; Miguel, J S; Anderson, K C; Palumbo, A; Kumar, S; Rajkumar, V; Durie, B; Richardson, P G

2016-05-01

The prognosis for patients multiple myeloma (MM) has improved substantially over the past decade with the development of new, more effective chemotherapeutic agents and regimens that possess a high level of anti-tumor activity. In spite of this important progress, however, nearly all MM patients ultimately relapse, even those who experience a complete response to initial therapy. Management of relapsed MM thus represents a vital aspect of the overall care for patients with MM and a critical area of ongoing scientific and clinical research. This comprehensive manuscript from the International Myeloma Working Group provides detailed recommendations on management of relapsed disease, with sections dedicated to diagnostic evaluation, determinants of therapy, and general approach to patients with specific disease characteristics. In addition, the manuscript provides a summary of evidence from clinical trials that have significantly impacted the field, including those evaluating conventional dose therapies, as well as both autologous and allogeneic stem cell transplantation. Specific recommendations are offered for management of first and second relapse, relapsed and refractory disease, and both autologous and allogeneic transplant. Finally, perspective is provided regarding new agents and promising directions in management of relapsed MM.

Perfluorinated alkylated substances (PFAS) in the European Nordic environment

Energy Technology Data Exchange (ETDEWEB)

Berger, U. [Norwegian Institute of Air Research (NILU), Tromso (Norway); Jaernberg, U. [Institute of Applied Environmental Research (ITM), Stockholm (Sweden); Kallenborn, R. [Norwegian Institute of Air Research (NILU), Kjeller (Norway)

2004-09-15

Perfluorinated alkylated substances (PFAS) have been industrially produced for several decades and are applied as stain and water repellents for surface treatment of textiles, carpets, leather and paper products. Perfluorooctane sulfonate (PFOS), a degradation product of several PFAS, has recently gained considerable attention because of its ubiquitous distribution in the environment and its presence in human blood plasma. Though most of the production volume of PFOS-based chemicals has been voluntarily phased out by the manufacturers, similar compounds with perfluorinated chains, including perfluorinated carboxylic acids, continue to be employed for comparable applications. A first screening project on the distribution of PFAS in the environment of five Nordic countries was supported and financed by the Nordic Council of Ministers through the Chemicals Group and the Environmental Monitoring Group and national institutions. The aim of the study was to assess the levels and distribution of PFAS in the Nordic environment and to trace differences in contaminant concentrations and patterns between different countries and types of matrices.

Avoidable cancer cases in the Nordic countries - The impact of overweight and obesity.

Science.gov (United States)

Andersson, Therese M-L; Weiderpass, Elisabete; Engholm, Gerda; Lund, Anne-Sofie Q; Olafsdottir, Elinborg; Pukkala, Eero; Stenbeck, Magnus; Storm, Hans

2017-07-01

Several types of cancers are causally linked to overweight and obesity, which are increasing in the Nordic countries. The aim of this study was to quantify the proportion of the cancer burden linked to overweight and obesity in the Nordic countries and estimate the potential for cancer prevention. Under different prevalence scenarios of overweight and obesity, the number of cancer cases in the Nordic countries in the next 30 years (i.e. 2016-2045) was estimated for 13 cancer sites and compared to the projected number of cancer cases if the prevalence stayed constant. The Prevent macro-simulation model was used. Over the period 2016-2045, 205,000 cancer cases out of the 2.1 million expected for the 13 cancer sites (9.5%) that have been studied, could be avoided in the Nordic countries by totally eliminating overweight and obesity in the target population. The largest proportional impact was found for oesophageal adenocarcinoma (24%), and the highest absolute impact was observed for colon (44638) and postmenopausal breast cancer (41135). Decreased prevalence of overweight and obesity would reduce the cancer burden in the Nordic countries. The results from this study form an important step to increase awareness and priorities in cancer control by controlling overweight and obesity in the population. Copyright © 2017 Elsevier Ltd. All rights reserved.

Per and polyfluorinated substances in the Nordic Countries

DEFF Research Database (Denmark)

Posner, Stefan; Roos, Sandra; Brunn Poulsen, Pia

This Tema Nord report presents a study based on open information and custom market research to review the most common perfluorinated substances (PFC) with less focus on PFOS and PFOA. The study includes three major parts: 1) Identification of relevant per-and polyfluorinated substances and their ......This Tema Nord report presents a study based on open information and custom market research to review the most common perfluorinated substances (PFC) with less focus on PFOS and PFOA. The study includes three major parts: 1) Identification of relevant per-and polyfluorinated substances...... and their use in various industrial sectors in the Nordic market by interviews with major players and database information 2) Emissions to and occurence in the Nordic environment of the substances described in 1) 3) A summary of knowledge of the toxic effects on humans and the environment of substances...

Ten Perspectives on Nordic Energy. Final report for the first phase of the Nordic Energy Perspectives project

International Nuclear Information System (INIS)

Ryden, Bo

2006-09-01

Nordic Energy Perspectives is an interdisciplinary energy research project which, from a holistic perspective, analyses and creates new insights into the consequences for energy markets and energy systems of the goals and instruments of energy policy in the light of new conditions. The project's aim is to provide better bases for decisions on energy and environmental policy at both national and international levels. It is intended to contribute to constructive dialogue between researchers, politicians, authorities and actors on the energy markets. A first phase of the project has been carried out during Apr 2005 - Sep 2006. This report summarises the most important results. Around fifteen current research issues have been analysed. Some of these issues have been analysed in detail, while others have been studied more generally. This means that we can present a comprehensive flora of results in a number of areas, whereas in regard to other questions the analysis is less deep and the conclusions are not as firmly grounded. We have nonetheless chosen to present the entire range of results in this final report. An objective of Nordic Energy Perspectives has been to create a forum for fact-based discussion and dialogue between decision-makers and other energy actors from different disciplines and different countries. Today this forum is fully active. We are very eager that the forum should survive and that the discussion should continue concerning the themes treated by Nordic Energy Perspectives. Hence, for each of the chapters 1-17 below, we identify the researchers whom the reader can contact for further dialogue. The ten perspectives, which are based on contributions from the whole research group, have the following headlines: Costly early learnings from the first year of EU ETS: Unforeseen price levels hit industries hard; Market based support schemes - do they really work as intended; New decade in the Nordic energy markets; Reduced CO 2 emissions and more

Multiple myeloma: Results of radiotherapy in skeletal lesions

International Nuclear Information System (INIS)

Budach, V.; Hueltenschmidt, B.; Stuschke, M.; Stueben, G.; Sack, H.; Bamberg, M.

1991-01-01

In this retrospective study the records of 157 patients with the diagnosis of multiple myeloma were evaluated with regard to subjective pain relief after a series of radiation therapy at 389 local sites. The most frequently treated region was the spine (50.2%), followed by the thoracic wall (17.9%) and the upper and lower extremities (17.8%). The median survival after diagnosis of all patients was 36 months. 88.4% of all treated sites showed good to moderate response in terms of pain remission after irradiation. It is shown that pain relief is significantly dependent on the total dose but independent of the dose per fraction. A total dose of 30 Gy in two weeks (5x3 Gy/week) is recommended as a well tolerated and reasonable treatment option to achieve maximum palliation and minimum hospitalization time for patients in whom multiple myeloma is diagnosed. (orig.) [de

Dermatological moulage collections in the Nordic countries

DEFF Research Database (Denmark)

Worm, A M.; Sinisalo, H.; Eilertsen, G.

2017-01-01

BACKGROUND: The art of producing and acquiring dermatological wax models, moulages, flourished all over Europe in the beginning of the twentieth century, whereas very little is known about the existence of moulage collections in the Nordic countries. OBJECTIVE: The aim of this paper is to elucidate...... the presence, the origin, the production place, the use and the condition of dermatological moulage collections in the Nordic countries. METHODS: In each Nordic country, an extensive survey was undertaken during spring 2016. Dermatological departments, museums with medical collections, persons assumed to have...... specific information about wax moulages as well as secondary sources were contacted and interviewed. RESULTS: Several hitherto undescribed collections have survived in each country, most however damaged and in disrepair. One Danish and part of a Finnish collection have been restored. Only few moulages...

Sea-ice cover in the Nordic Seas and the sensitivity to Atlantic water temperatures

Science.gov (United States)

Jensen, Mari F.; Nisancioglu, Kerim H.; Spall, Michael A.

2017-04-01

Changes in the sea-ice cover of the Nordic Seas have been proposed to play a key role for the dramatic temperature excursions associated with the Dansgaard-Oeschger events during the last glacial. However, with its proximity to the warm Atlantic water, how a sea-ice cover can persist in the Nordic Seas is not well understood. In this study, we apply an eddy-resolving configuration of the Massachusetts Institute of Technology general circulation model with an idealized topography to study the presence of sea ice in a Nordic Seas-like domain. We assume an infinite amount of warm Atlantic water present in the south by restoring the southern area to constant temperatures. The sea-surface temperatures are restored toward cold, atmospheric temperatures, and as a result, sea ice is present in the interior of the domain. However, the sea-ice cover in the margins of the Nordic Seas, an area with a warm, cyclonic boundary current, is sensitive to the amount of heat entering the domain, i.e., the restoring temperature in the south. When the temperature of the warm, cyclonic boundary current is high, the margins are free of sea ice and heat is released to the atmosphere. We show that with a small reduction in the temperature of the incoming Atlantic water, the Nordic Seas-like domain is fully covered in sea ice. Warm water is still entering the Nordic Seas, however, this happens at depths below a cold, fresh surface layer produced by melted sea ice. Consequently, the heat release to the atmosphere is reduced along with the eddy heat fluxes. Results suggest a threshold value in the amount of heat entering the Nordic Seas before the sea-ice cover disappears in the margins. We study the sensitivity of this threshold to changes in atmospheric temperatures and vertical diffusivity.

Retail margins and the effects of an integrated Nordic end user market for electricity

Energy Technology Data Exchange (ETDEWEB)

Damsgaard, Niclas; Roempoetti, Marie

2007-09-15

There is an ongoing discussion about the need for further and deeper integration of the Nordic electricity market. Following the Nordic Council of Minister's summit in Akureyri in 2004 this work has been intensified. NordREG and Nordel have produced several studies on the integration of the market. Work is currently being done on a Nordic common market platform for balancing services and a Nordic balancing agreement, the market design for a common market and a common model for supply switches and several other issues. This study should be seen in relationship with these other studies and we have deliberately aimed at avoiding overlaps. An integrated Nordic retail market for electricity would in principle imply a common market for 14 million customers served by several hundred retail companies. The question asked in this study is what are the benefits for the customers of such a development? In order to create a common Nordic market there are several barriers that needs to be overcome. There are technical barriers such as differences in IT-systems, regulatory barriers caused by differences in e.g. the responsibilities and the regulation of the DSOs and finally of course business barriers that exists for all cross-border businesses. A well-functioning Nordic retail market would lead to price equalisation - at least if the costs are equal. This would mean that particularly customers in areas with high retail margins could benefit from a joint Nordic market. Furthermore, dilution of market power could lead to more intense competition which in turn both could lead to lower costs and lower margins. In this report we focus on the possible direct effects on prices. In addition to this it is likely that there are efficiency gains, for instance through decreased costs in developing IT-systems etc. for a larger market which would decrease costs both for the suppliers and for DSOs. There might also be other economies-of-scales arising from a larger market. The possible

Acquired amylase production induced by radiotherapy in a myeloma patient

Energy Technology Data Exchange (ETDEWEB)

Yamakawa, Tamami; Nagoshi, Haruhisa; Takahashi, Atushi [Saint Marianna Univ., Kawasaki, Kanagawa (Japan). School of Medicine] [and others

1995-10-01

A 55-year-old patient with multiple myeloma (IgG-{lambda}) diagnosed in November 1988 was admitted because of bone pain throughout the body. After plasmapheresis and several courses of chemotherapy, a massive tumor of the left thoracic wall involving the rib appeared. Radiotherapy was performed to ameliorate the severe chest pain, after which myelomatous pleural effusion appeared on the left side. The serum, urine and pleural effusion revealed increased activity of amylase of the salivary type. Amylase activity was also detected in the supernatant of myeloma cells cultured from pleural effusion. We reviewed 12 cases of ectopic amylase-producing multiple myeloma. All the cases except one have been reported from Japan, and hyperamylasemia in these cases was detected at diagnosis or during course of the illness. Moreover, cytogenetic analysis of myeloma cells of previous reports revealed structural abnormalities including chromosome 1, near the amylase gene locus. This case also showed t (1; 10) (q21?; q26) by examination of 8 metaphase derived from bone marrow. These observations suggested that ectopic amylase production was induced by irradiation to the plasmacytoma of thoracic wall. (author).

Acquired amylase production induced by radiotherapy in a myeloma patient

International Nuclear Information System (INIS)

Yamakawa, Tamami; Nagoshi, Haruhisa; Takahashi, Atushi

1995-01-01

A 55-year-old patient with multiple myeloma (IgG-λ) diagnosed in November 1988 was admitted because of bone pain throughout the body. After plasmapheresis and several courses of chemotherapy, a massive tumor of the left thoracic wall involving the rib appeared. Radiotherapy was performed to ameliorate the severe chest pain, after which myelomatous pleural effusion appeared on the left side. The serum, urine and pleural effusion revealed increased activity of amylase of the salivary type. Amylase activity was also detected in the supernatant of myeloma cells cultured from pleural effusion. We reviewed 12 cases of ectopic amylase-producing multiple myeloma. All the cases except one have been reported from Japan, and hyperamylasemia in these cases was detected at diagnosis or during course of the illness. Moreover, cytogenetic analysis of myeloma cells of previous reports revealed structural abnormalities including chromosome 1, near the amylase gene locus. This case also showed t (1; 10) (q21?; q26) by examination of 8 metaphase derived from bone marrow. These observations suggested that ectopic amylase production was induced by irradiation to the plasmacytoma of thoracic wall. (author)

On the Role of family Policy in the Nordic Countries

DEFF Research Database (Denmark)

Knudsen, Lisbeth B.

obligations, for gender equality and most recently, a growing concern for securing time for both work and private life. These policy measures have aimed at improving living conditions for families with children and thus only indirectly at increasing the propensity to have children. The paper argues......Compared to other countries, e.g. in Southern Europe the fertility in the Nordic countries is relatively high. This paper discusses the role of Family Policy in the Nordic Countries in this respect. The Nordic countries experienced a decline in fertility in the first three decades of the 20th...... century where after the total fertility rates increased until the late 1960s where a new decline took off. Throughout the studied period, policy measures influencing living conditions for families have been influenced by concern for population development, for reconciliation between family and work...

A Phase I Dose-Escalation Study of Antibody BI-505 in Relapsed/Refractory Multiple Myeloma

DEFF Research Database (Denmark)

Hansson, Markus; Gimsing, Peter; Badros, Ashraf

2015-01-01

PURPOSE: This multicenter, first-in-human study evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of BI-505, a human anti-ICAM-1 monoclonal antibody, in advanced relapsed/refractory multiple myeloma patients. EXPERIMENTAL DESIGN: BI-505 was given intravenously, every 2 weeks...... generally mild to moderate, and those attributed to study medication were mostly limited to the first dose and manageable with premedication and slower infusion. No maximum tolerated dose was identified. BI-505's half-life increased with dose while clearance decreased, suggesting target-mediated clearance...

Impact of Seawater Nonlinearities on Nordic Seas Circulation

Science.gov (United States)

Helber, R. W.; Wallcraft, A. J.; Shriver, J. F.

2017-12-01

The Nordic Seas (Greenland, Iceland, and Norwegian Seas) form an ocean basin important for Arctic-mid-latitude climate linkages. Cold fresh water from the Arctic Ocean and warm salty water from the North Atlantic Ocean meet in the Nordic Seas, where a delicate balance between temperature and salinity variability results in deep water formation. Seawater non-linearities are stronger at low temperatures and salinities making high-latitude oceans highly subject to thermbaricity and cabbeling. This presentation highlights and quantifies the impact of seawater non-linearities on the Nordic Seas circulation. We use two layered ocean circulation models, the Hybrid Coordinate Ocean Model (HYOCM) and the Modular Ocean Model version 6 (MOM6), that enable accurate representation of processes along and across density or neutral density surfaces. Different equations-of-state and vertical coordinates are evaluated to clarify the impact of seawater non-linearities. Present Navy systems, however, do not capture some features in the Nrodic Seas vertical structure. For example, observations from the Greenland Sea reveal a subsurface temperature maximum that deepens from approximately 1500 m during 1998 to 1800 m during 2005. We demonstrate that in terms of density, salinity is the largest source of error in Nordic Seas Navy forecasts, regional scale models can represent mesoscale features driven by thermobaricity, vertical coordinates are a critical issue in Nordic Sea circulation modeling.

Ecological and social dimensions of ecosystem restoration in the Nordic countries

DEFF Research Database (Denmark)

Hagen, Dagmar; Svavarsdottir, Kristin; Nilsson, Christer

2013-01-01

An international overview of the extent and type of ecological restoration can offer new perspectives for understanding, planning, and implementation. The Nordic countries, with a great range of natural conditions but historically similar social and political structures, provide an opportunity...... and among countries, both in the Nordic countries and internationally. An obvious advantage of such cooperation is that a wider range of experiences from different habitats and different socio-economic conditions becomes available and thus provides a more solid basis for developing practical solutions...... to compare restoration approaches and efforts across borders. The aim of this study was to explore variation in ecological restoration using the Nordic countries as an example. We used recent national assessments and expert evaluations of ecological restoration. Restoration efforts differed among countries...

Competitive policies in the Nordic energy research and innovation area - eNERGIA : Synthesis report

Energy Technology Data Exchange (ETDEWEB)

Klitkou, Antje; Pedersen, Trond Einar; Scordato, Lisa; Mariussen, Aage

2008-07-01

This report outlines the energy research and innovation policy in the Nordic and Baltic countries - Denmark, Finland, Iceland, Norway, Sweden, Estonia, Latvia and Lithuania. The report is the result of the research project Competitive policies in the Nordic Energy Research and Innovation Area (eNERGIA). The project was co-funded by Nordic Energy Research and NIFU STEP. The objective of the project was to determine possible policy interventions targeted at the development and commercial promotion of promising renewable energy production technologies in the Nordic countries. The report is based on an analysis of the framework conditions for the sector innovation systems for energy production, with a focus on research and innovation policy in the Nordic and Baltic countries. We identified the key actors and institutions in all the eight countries studied. In addition, we conducted a performance assessment based on the quantitative indicators of publishing and patenting, international collaboration and funding data. Using these indicators as a basis, we conducted an analysis of the strengths, weaknesses, opportunities and threats (SWOT analysis) of the Nordic sector innovation systems for energy production. This analysis identified common or diverging characteristics, challenges, framework conditions, energy-technology specialisation and, most important of all, cases of good practice in key technologies. The project included two workshops, and the results of these are also reported here. The outcomes of the workshops have been used in several parts of the project: A Nordic workshop on the environmental consequences of deployment at scale of these technologies to replace existing energy systems, with a focus on wind energy and photovoltaic energy, carbon dioxide capture and storage, and second-generation bioenergy. A Nordic workshop on policy implications for Nordic Energy Research. The report comprises three parts: Part 1: Country reports Part 2: Technology reports

Adherence to a Healthy Nordic Diet and Risk of Stroke: A Danish Cohort Study.

Science.gov (United States)

Hansen, Camilla Plambeck; Overvad, Kim; Kyrø, Cecilie; Olsen, Anja; Tjønneland, Anne; Johnsen, Søren Paaske; Jakobsen, Marianne Uhre; Dahm, Christina Catherine

2017-02-01

Specific dietary patterns, including the Mediterranean diet, have been associated with stroke prevention. Our aim was to investigate whether adherence to a healthy Nordic diet, including fish, apples and pears, cabbages, root vegetables, rye bread, and oatmeal, was associated with risk of stroke. Incident cases of stroke among 55 338 men and women from the Danish Diet, Cancer and Health cohort were identified from the Danish National Patient Register and verified by review of records. Cases of ischemic stroke were further subclassified based on etiology according to the TOAST classification system (Trial of Org 10172 in Acute Stroke Treatment). Information on diet was collected at baseline (1993-1997) using a semiquantitative food-frequency questionnaire. Cox proportional hazards models were used to estimate hazards ratios of total stroke and subtypes of ischemic and hemorrhagic stroke. During a median follow-up of 13.5 years, 2283 cases of incident stroke were verified, including 1879 ischemic strokes. Adherence to a healthy Nordic diet, as reflected by a higher Healthy Nordic Food Index score, was associated with a lower risk of stroke. The hazards ratio comparing an index score of 4 to 6 (high adherence) with an index score of 0 to 1 (low adherence) was 0.86 (95% confidence interval 0.76-0.98) for total stroke. Inverse associations were observed for ischemic stroke, including large-artery atherosclerosis. No trend was observed for hemorrhagic stroke; however, a statistically insignificant trend was observed for intracerebral hemorrhage. Our findings suggest that a healthy Nordic diet may be recommended for the prevention of stroke. © 2017 American Heart Association, Inc.

Iodine status in the Nordic countries – past and present

Directory of Open Access Journals (Sweden)

Helena Filipsson Nyström

2016-06-01

Full Text Available Background: Adequate iodine nutrition is dependent on ground water content, seafood, and, as many countries use iodized cow fodder, dairy products. In most countries, salt fortification programs are needed to assure adequate iodine intake. Objectives: The objectives are threefold: 1 to describe the past and present iodine situation in the Nordic countries, 2 to identify important gaps of knowledge, and 3 to highlight differences among the Nordic countries’ iodine biomonitoring and fortification policies. Design: Historical data are compared with the current situation. The Nordic countries’ strategies to achieve recommended intake and urine iodine levels and their respective success rates are evaluated. Results: In the past, the iodine situation ranged from excellent in Iceland to widespread goiter and cretinism in large areas of Sweden. The situation was less severe in Norway and Finland. According to a 1960 World Health Organization (WHO report, there were then no observations of iodine deficiency in Denmark. In Sweden and Finland, the fortification of table salt was introduced 50–75 years ago, and in Norway and Finland, the fortification of cow fodder starting in the 1950s helped improve the population's iodine status due to the high intake of milk. In Denmark, iodine has been added to household salt and salt in bread for the past 15 years. The Nordic countries differ with regard to regulations and degree of governmental involvement. There are indications that pregnant and lactating women, the two most vulnerable groups, are mildly deficient in iodine in several of the Nordic countries. Conclusion: The Nordic countries employ different strategies to attain adequate iodine nutrition. The situation is not optimal and is in need of re-evaluation. Iodine researchers, Nordic national food administrations, and Nordic governmental institutions would benefit from collaboration to attain a broader approach and guarantee good iodine health for all.

Iodine status in the Nordic countries – past and present

Science.gov (United States)

Nyström, Helena Filipsson; Brantsæter, Anne Lise; Erlund, Iris; Gunnarsdottir, Ingibjörg; Hulthén, Lena; Laurberg, Peter; Mattisson, Irene; Rasmussen, Lone Banke; Virtanen, Suvi; Meltzer, Helle Margrete

2016-01-01

Background Adequate iodine nutrition is dependent on ground water content, seafood, and, as many countries use iodized cow fodder, dairy products. In most countries, salt fortification programs are needed to assure adequate iodine intake. Objectives The objectives are threefold: 1) to describe the past and present iodine situation in the Nordic countries, 2) to identify important gaps of knowledge, and 3) to highlight differences among the Nordic countries’ iodine biomonitoring and fortification policies. Design Historical data are compared with the current situation. The Nordic countries’ strategies to achieve recommended intake and urine iodine levels and their respective success rates are evaluated. Results In the past, the iodine situation ranged from excellent in Iceland to widespread goiter and cretinism in large areas of Sweden. The situation was less severe in Norway and Finland. According to a 1960 World Health Organization (WHO) report, there were then no observations of iodine deficiency in Denmark. In Sweden and Finland, the fortification of table salt was introduced 50–75 years ago, and in Norway and Finland, the fortification of cow fodder starting in the 1950s helped improve the population's iodine status due to the high intake of milk. In Denmark, iodine has been added to household salt and salt in bread for the past 15 years. The Nordic countries differ with regard to regulations and degree of governmental involvement. There are indications that pregnant and lactating women, the two most vulnerable groups, are mildly deficient in iodine in several of the Nordic countries. Conclusion The Nordic countries employ different strategies to attain adequate iodine nutrition. The situation is not optimal and is in need of re-evaluation. Iodine researchers, Nordic national food administrations, and Nordic governmental institutions would benefit from collaboration to attain a broader approach and guarantee good iodine health for all. PMID:27283870

Development of a "Myeloma Risk Score" using a population-based registry on paraproteinemia and myeloma

NARCIS (Netherlands)

Ong, F; Hermans, J; Noordijk, E M; De Kieviet, W; Seelen, P J; Wijermans, P W; Kluin-Nelemans, J C

1997-01-01

Diagnostic systems for monoclonal gammopathies use bone marrow and X-ray examinations to exclude multiple myeloma (MM). Data from a population-based registry of unselected patients with paraproteinemia indicate that these tests are often done only when MM is suspected. We used 441 randomly selected

Magnetic resonance imaging of the spine in multiple myeloma

International Nuclear Information System (INIS)

Tanaka, Masato; Nakahara, Shinnosuke; Koura, Hiroshi; Kai, Nobuo; Asaumi, Koji; Tanaka, Shunsuke; Sezaki, Tatsuo; Fukuda, Shunichi; Sunami, Kazutaka

2000-01-01

The characteristics of diagnostic imaging of the spine in multiple myeloma were examined. Twenty-one patients with stage II-III multiple myeloma (male=12, female=9, mean age=64) underwent MRI of the spine. Other diagnostic imaging modalities used in these patients included, CT bone scintigraphy, and radiography. All images of the spine were assessed and compared with the MRI images. The type of progression was evaluated based on the tumor distribution classification established by Sezaki. T1-weighted images of all 21 patients showed low signals in vertebral bodies, including 14 cases with a focal low signal intensity and 7 cases with diffuse low signal intensity. On the T2-weighted images, 15 of the 21 cases (71%) showed equivalent signals, while T2*-weighted images obtained by the field-echo method yielded high signals in 10 out of 11 cases. It was difficult to differentiate between senile osteoporosis and multiple myeloma by MRI, but CT images clearly distinguished between them. The results suggested that fat-suppressive T1-contrast images and T2*-weighted images are useful in detecting lesions, especially focal low signal intensity lesions. Patients with the multiple-lesion-tumor type of disease were more likely to develop paralysis more than those with the diffuse myeloproliferative type. Thus, the tumor distribution classification established by Sezaki was useful in considering radiotherapy for the treatment of patients at risk of paralysis. Bone scintigraphy revealed accumulation only in spinal lesions caused by compression fractures, while CT appeared to be useful in localizing the diffuse myeloproliferative type of lesions. The problems associated with diagnosis by MRI are differentiation of multiple myeloma from senile osteoporosis and metastatic bone tumors of the spine. There are few specific findings in multiple myeloma. (K.H.)

Advancements in Nanomedicine for Multiple Myeloma.

Science.gov (United States)

Detappe, Alexandre; Bustoros, Mark; Mouhieddine, Tarek H; Ghoroghchian, P Peter

2018-06-01

In the past decades, considerable progress has been made in our understanding and treatment of multiple myeloma. Several challenges remain including our abilities to longitudinally image tumor responses to treatment, to combine various therapeutic agents with different mechanisms of action but with overlapping toxicities, and to efficiently harness the power of the immune system to augment remission and/or to induce permanent cures. Nanomedicine may help to address many of these outstanding issues, affording novel diagnostic capabilities and offering disruptive technologies that promise to revolutionize treatment. Here, we review recent developments and the future of nanomedicine for multiple myeloma, highlighting new considerations in nanoparticle designs that may help to augment active targeting, to facilitate longitudinal imaging, and to improve drug delivery. Copyright © 2018 Elsevier Ltd. All rights reserved.

Intravascular ultrasound assessment of minimumlumen area and intimal hyperplasia in in-stent restenosis after drug-eluting or bare-metal stent implantation. The Nordic Intravascular Ultrasound Study (NIVUS)

DEFF Research Database (Denmark)

Jensen, Lisette Okkels; Vikman, Saila; Antonsen, Lisbeth

2017-01-01

presenting with a DES or bare-metal stent (BMS) in-stent restenosis. Methods: The ``Nordic Intravascular Ultrasound Study (NIVUS)'' study was conducted in Nordic and Baltic countries as a prospective multicenter registry. Two hundred nine patients (DES n = 121 and BMS n = 88) with instent restenosis were...

Monitoring and Benchmarking eHealth in the Nordic Countries.

Science.gov (United States)

Nøhr, Christian; Koch, Sabine; Vimarlund, Vivian; Gilstad, Heidi; Faxvaag, Arild; Hardardottir, Gudrun Audur; Andreassen, Hege K; Kangas, Maarit; Reponen, Jarmo; Bertelsen, Pernille; Villumsen, Sidsel; Hyppönen, Hannele

2018-01-01

The Nordic eHealth Research Network, a subgroup of the Nordic Council of Ministers eHealth group, is working on developing indicators to monitor progress in availability, use and outcome of eHealth applications in the Nordic countries. This paper reports on the consecutive analysis of National eHealth policies in the Nordic countries from 2012 to 2016. Furthermore, it discusses the consequences for the development of indicators that can measure changes in the eHealth environment arising from the policies. The main change in policies is reflected in a shift towards more stakeholder involvement and intensified focus on clinical infrastructure. This change suggests developing indicators that can monitor understandability and usability of eHealth systems, and the use and utility of shared information infrastructure from the perspective of the end-users - citizens/patients and clinicians in particular.

Zastosowanie Nordic Walking w turnusie rehabilitacyjnym osób po usunięciu krtani = Use of Nordic Walking in a rehabilitation of the people after total laryngectomy

Directory of Open Access Journals (Sweden)

Agnieszka Hamerlińska - Latecka

2016-10-01

  Słowa kluczowe: laryngektomia, logopeda, Nordic Walking, rehabilitacja, turnus Key words: laryngectomy, speech therapist, Nordic Walking, rehabilitation, holidays health   Streszczenie Turnusy rehabilitacyjne dla osób po usunięciu krtani organizowane są średnio raz do roku. Specjalistami prowadzącymi zajęcia podczas takich wyjazdów są najczęściej: fizjoterapeuta, psycholog i logopeda. Celem takich turnusów jest usprawnianie fizyczne, psychiczne i społeczne. Celem niniejszego artykułu jest przedstawienie wyników badań dotyczących zastosowania przez osoby po laryngektomii całkowitej metody Nordic Walking podczas pobytu na wczasach zdrowotnych.   Abstract Rehabilitation for patients after laryngectomy are organized on average once a year. Specialists lecturers during such trips are the most common: physical therapist, psychologist and speech therapist. The purpose of these camps is the improvement of the physical, mental and social. The purpose of this article is to present the results of studies regarding the application by a person after total laryngectomy methods Nordic Walking while on holidays health.

Challenges for future family policies in the Nordic countries

DEFF Research Database (Denmark)

responsibility of parents, but also a responsibility to be shared with society. Moreover, the Nordic welfare model goes hand-in-hand with the women’s movement by offering opportunities for women, as well as men, to also participate in education and employment. The question remains how more recent trends...... such as New Public Management principles and increased focus on children’s positions and rights affect family policies in the Nordic countries? The authors, who come from all five Nordic countries, discuss the following topics: issues related to family demographics, children’s position in society...

Report of the European Myeloma Network on multiparametric flow cytometry in multiple myeloma and related disorders

DEFF Research Database (Denmark)

Rawstron, Andy C; Orfao, Alberto; Beksac, Meral

2008-01-01

The European Myeloma Network (EMN) organized two flow cytometry workshops. The first aimed to identify specific indications for flow cytometry in patients with monoclonal gammopathies, and consensus technical approaches through a questionnaire-based review of current practice in participating...

Telehealth ICT Infrastructures in the Nordic Countries

DEFF Research Database (Denmark)

Jørgensen, Daniel Bjerring; Hallenborg, Kasper

2015-01-01

This paper presents an overview and recommendations of ICT infrastructures and reference architectures for telehealth in the Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden). This study shows that so far only Denmark has designed a complete reference architecture, and by the end...

Survey of system responsibility in the Nordic countries. Final report

International Nuclear Information System (INIS)

2005-02-01

In September 2004 the Nordic Council of Ministers asked Nordel to perform some tasks and present the results to the Council on 1 March 2005. One of the tasks is to survey how system responsibility is defined and executed in the different Nordic countries. According to the Nordic Council of Ministers, the survey shall illuminate similarities and differences between the countries and assess the reasons for the differences. Nordel is asked to present a joint view system responsibility in the Nordic countries. Among other things, the responsibility for the system operators and the participants in the market shall be defined. The definition shall also include the distribution of costs between costs for network business and costs for business in competition. This shall be done in a way that creates a common platform for the further harmonisation work and continuous positive development of the Nordic electricity market. It is also important to identify the need for changes in e.g. legislation and guidelines in the different countries as a consequence of an implementation of a common definition in the Nordic countries. Areas to be included in the task are among others, balance settlement, security of supply, congestion management and system services. (BA)

Regulated and unregulated Nordic retail prices

International Nuclear Information System (INIS)

Johnsen, Tor Arnt; Olsen, Ole Jess

2011-01-01

Nordic residential electricity consumers can now choose among a number of contracts and suppliers. A large number of households have continued to purchase electricity from the incumbent supplier at default contract terms. In this paper, we compare the situation for such passive customers. Danish default prices are regulated whereas default prices in the other countries are unregulated. Systematic price differences exist among the Nordic countries. However, as wholesale prices sometimes differ the gross margin is a more relevant indicator. Regulated gross margins are lower in Denmark than in Sweden but higher than in Norway and Finland. Because of market design Norwegian default contracts are competitive whereas Swedish contracts provide the retailer with some market power. We interpret the low Finnish margins as a result of municipal retailers continuing traditional pricing from the monopoly period. Danish margins are higher than the competitive Norwegian margins but are earned from a much lower level of consumption. The annually margins earned per consumer are very close in the two countries, which indicates that the Danish regulation is achieving its objective of approaching competitive prices. - Highlights: → Prices of active and passive Nordic residential electricity consumers are compared. → Active consumers get lower prices in Sweden but not in Norway. → Prices of passive consumers differ considerably among the four Nordic countries. → Danish regulated prices compare well with unregulated prices in the other countries. → Passive consumers in Finland have low prices compared with the other countries.

Regulated and unregulated Nordic retail prices

Energy Technology Data Exchange (ETDEWEB)

Johnsen, Tor Arnt, E-mail: tor.a.johnsen@bi.no [Norwegian School of Management BI, NO-0442 Oslo (Norway); Olsen, Ole Jess, E-mail: ojo@ruc.dk [Department of Environmental, Social and Spatial Change (ENSPAC), Roskilde University, Building 10.1, Universitetsvej 1, DK-4000, Roskilde (Denmark)

2011-06-15

Nordic residential electricity consumers can now choose among a number of contracts and suppliers. A large number of households have continued to purchase electricity from the incumbent supplier at default contract terms. In this paper, we compare the situation for such passive customers. Danish default prices are regulated whereas default prices in the other countries are unregulated. Systematic price differences exist among the Nordic countries. However, as wholesale prices sometimes differ the gross margin is a more relevant indicator. Regulated gross margins are lower in Denmark than in Sweden but higher than in Norway and Finland. Because of market design Norwegian default contracts are competitive whereas Swedish contracts provide the retailer with some market power. We interpret the low Finnish margins as a result of municipal retailers continuing traditional pricing from the monopoly period. Danish margins are higher than the competitive Norwegian margins but are earned from a much lower level of consumption. The annually margins earned per consumer are very close in the two countries, which indicates that the Danish regulation is achieving its objective of approaching competitive prices. - Highlights: > Prices of active and passive Nordic residential electricity consumers are compared. > Active consumers get lower prices in Sweden but not in Norway. > Prices of passive consumers differ considerably among the four Nordic countries. > Danish regulated prices compare well with unregulated prices in the other countries. > Passive consumers in Finland have low prices compared with the other countries.

Nordic study on reactor waste. Technical part 3

International Nuclear Information System (INIS)

1981-08-01

The ground disposal alternatives examined in the Nordic study are based on establishment of relevant product specifications which can be adapted to the safety analysis of the entire waste handling sequence. Such product specifications would in turn influence the choice of incorporation techniques and may enable an optimization of the process. In order to interprete the small-scale laboratory tests with respect to long-term performance of full-scale products there were accomplished: - qualitative evaluations of the relevance of product properties for normal and abnormal events during storage, transport and disposal; - attempts to quantify the relevance of different properties, i.e. their influence on radiation doses from different stages of well specified waste management system; - assessments of available laboratory tests and of correlations between results from such tests and the long-term performance of full-scale technical products; - studies of reaction mechanisms and parameters that can affect the long-term performance of disposed products; - laboratory incorporation experiments to study impacts of process variables on the fixation of ion exchange wastes in cement and bitumen; - full-scale tests to study product performance under simulated accident conditions. (EG)

Power engineers of the Nordic and Baltic countries in Finland

International Nuclear Information System (INIS)

Veski, Rein

1999-01-01

The Estonian delegation had been invited by Helsinki Energy to participate in the Nordic-Baltic District Heating Symposium. Distance heating enjoys a wide popularity in the Nordic countries. For heating purposes the use of biofuels, incl. peat, is highly recommended. Biofuels have found wide use in the Nordic countries, the share of peat being more considerable in Finland. The Estonians attended also the MODIS Workshop and made a visit to heat enterprises. (author)

Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®)—Patient Version

Science.gov (United States)

Plasma cell neoplasms occur when abnormal plasma cells or myeloma cells form tumors in the bones or soft tissues of the body. Multiple myeloma, plasmacytoma, lymphoplasmacytic lymphoma, and monoclonal gammopathy of undetermined significance (MGUS) are different types of plasma cell neoplasms. Find out about risk factors, symptoms, diagnostic tests, prognosis, and treatment for these diseases.

Multiple myeloma among atomic bomb survivors, Hiroshima and Nagasaki, 1950 - 76

International Nuclear Information System (INIS)

Ichimaru, Michito; Ishimaru, Toranosuke; Mikami, Motoko; Matsunaga, Masako.

1979-10-01

The relationship between atomic bomb exposure and the occurrence of multiple myeloma has been evaluated in a fixed cohort of approximately 100,000 A-bomb survivors and nonexposed controls during the period from October 1950 to December 1976. Analysis of these data revealed the standardized relative risk adjusted for city, sex, and age at the time of the bombs (ATB) to be significantly greater in the group of individuals who received 100 rad or more of radiation than in their controls. An excess risk became apparent in the high dose group about 20 years after exposure. The excess risk of multiple myeloma in those persons aged 20 - 59 ATB is estimated to be approximately 0.24 per million person-years per rad (PYR) in kerma dose and approximately 0.48 per million PYR in bone marrow dose. The interval between radiation exposure and the occurrence of an excess risk for multiple myeloma in the high dose population is considerably longer than that for leukemia. The cases of multiple myeloma observed in the high dose group showed no unusual clinical features. (author)

The Nordic Research programme on nuclear safety

International Nuclear Information System (INIS)

1992-06-01

Only two of the five Nordic countries (Denmark, Iceland, Finland, Norway and Sweden) - Sweden and Finland - operate nuclear power plants, but there are a number of nuclear installations close to their borders. Regular 4-year programmes were initiated in 1977, designated NKS-programmes. (NKS: Nordisk KerneSikkerhedsforskning - Nordic nuclear-safety research). The current fourth NKS-programme is, influenced by the Chernobyl accident, dominated by the necessity for acquiring knowledge on unexpected events and release of radioactive material from nuclear installations. The present programme is divided into the areas of emergency preparedness, waste and decommissioning, radioecology and reactor safety. It comprises a total of 18 projects, the results of which will later be published in the form of handbooks for use in cases of emergency etc. The future of joint Nordic project work in the nuclear safety field must be seen in the light of changing conditions in and around the Nordic countries, such as the opening of relations to neighbours in the east, the move towards the European Communities and the need for training a new generation of specialists in the nuclear field etc. Each project is described in considerable detail and a list of reports resulting from the third NKS-programme 1985-1989 is given. (AB)

EEN regulates the proliferation and survival of multiple myeloma cells by potentiating IGF-1 secretion

International Nuclear Information System (INIS)

Huang, Er-Wen; Xue, Sheng-Jiang; Li, Xiao-Yan; Xu, Suo-Wen; Cheng, Jian-Ding; Zheng, Jin-Xiang; Shi, He; Lv, Guo-Li; Li, Zhi-Gang; Li, Yue; Liu, Chang-Hui; Chen, Xiao-Hui; Liu, Hong; Li, Jie; Liu, Chao

2014-01-01

Highlights: • Levels of EEN expression paralleled with the rate of cell proliferation. • EEN was involved in the proliferation and survival of multiple myeloma (MM) cells. • EEN regulated the activity of IGF-1-Akt/mTOR pathway. • EEN regulated proliferation and survival of MM cells by enhancing IGF-1 secretion. - Abstract: The molecular mechanisms of multiple myeloma are not well defined. EEN is an endocytosis-regulating molecule. Here we report that EEN regulates the proliferation and survival of multiple myeloma cells, by regulating IGF-1 secretion. In the present study, we observed that EEN expression paralleled with cell proliferation, EEN accelerated cell proliferation, facilitated cell cycle transition from G1 to S phase by regulating cyclin-dependent kinases (CDKs) pathway, and delayed cell apoptosis via Bcl2/Bax-mitochondrial pathway. Mechanistically, we found that EEN was indispensable for insulin-like growth factor-1 (IGF-1) secretion and the activation of protein kinase B-mammalian target of rapamycin (Akt-mTOR) pathway. Exogenous IGF-1 overcame the phenotype of EEN depletion, while IGF-1 neutralization overcame that of EEN over-expression. Collectively, these data suggest that EEN may play a pivotal role in excessive cell proliferation and insufficient cell apoptosis of bone marrow plasma cells in multiple myeloma. Therefore, EEN may represent a potential diagnostic marker or therapeutic target for multiple myeloma

EEN regulates the proliferation and survival of multiple myeloma cells by potentiating IGF-1 secretion

Energy Technology Data Exchange (ETDEWEB)

Huang, Er-Wen [Guangzhou Institute of Forensic Science, Guangzhou (China); Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou (China); Xue, Sheng-Jiang [Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou (China); Li, Xiao-Yan [Department of Pharmacy, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou (China); Xu, Suo-Wen [Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou (China); Cheng, Jian-Ding; Zheng, Jin-Xiang [Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou (China); Shi, He; Lv, Guo-Li; Li, Zhi-Gang; Li, Yue; Liu, Chang-Hui; Chen, Xiao-Hui; Liu, Hong [Guangzhou Institute of Forensic Science, Guangzhou (China); Li, Jie, E-mail: mdlijie@sina.com [Department of Anaesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou (China); Liu, Chao, E-mail: liuchaogaj@21cn.com [Guangzhou Institute of Forensic Science, Guangzhou (China)

2014-05-02

Highlights: • Levels of EEN expression paralleled with the rate of cell proliferation. • EEN was involved in the proliferation and survival of multiple myeloma (MM) cells. • EEN regulated the activity of IGF-1-Akt/mTOR pathway. • EEN regulated proliferation and survival of MM cells by enhancing IGF-1 secretion. - Abstract: The molecular mechanisms of multiple myeloma are not well defined. EEN is an endocytosis-regulating molecule. Here we report that EEN regulates the proliferation and survival of multiple myeloma cells, by regulating IGF-1 secretion. In the present study, we observed that EEN expression paralleled with cell proliferation, EEN accelerated cell proliferation, facilitated cell cycle transition from G1 to S phase by regulating cyclin-dependent kinases (CDKs) pathway, and delayed cell apoptosis via Bcl2/Bax-mitochondrial pathway. Mechanistically, we found that EEN was indispensable for insulin-like growth factor-1 (IGF-1) secretion and the activation of protein kinase B-mammalian target of rapamycin (Akt-mTOR) pathway. Exogenous IGF-1 overcame the phenotype of EEN depletion, while IGF-1 neutralization overcame that of EEN over-expression. Collectively, these data suggest that EEN may play a pivotal role in excessive cell proliferation and insufficient cell apoptosis of bone marrow plasma cells in multiple myeloma. Therefore, EEN may represent a potential diagnostic marker or therapeutic target for multiple myeloma.

The first report of myeloma with IgD κ and free κ in Indonesia

Directory of Open Access Journals (Sweden)

Riadi Wirawan

2011-08-01

Full Text Available IgD κ myeloma is a rare plasma cell neoplasm case and has never been reported before in Indonesia. In normal condition, IgD level in blood is very low, therefore increase of IgD level in myeloma could be missed by serum protein electrophoresis. A case of a 59 years old female with severe bone pain is reported. In radiology evaluation, there were thoracal compression fracture and thoracal foramen narrowing. For this patient, the myeloma diagnosis was based on WHO criteria, the stage IIIb was based on Durie and Salmon criteria, and bad prognosis with prognostic index stage III diagnosis was based on International Prognostic Index from International Myeloma Working Group, respectively. In serum protein electrophoresis we found a very small monoclonal spike and in immunofi xation there were monoclonal IgD κ and free light chain κ. (Med J Indones 2011; 20:217-21Keywords: immunofixation, myeloma IgD κ, protein electrophoresis

Liver transplantation in the Nordic countries - An intention to treat and post-transplant analysis from The Nordic Liver Transplant Registry 1982-2013

DEFF Research Database (Denmark)

Fosby, Bjarte; Melum, Espen; Bjøro, Kristian

2015-01-01

AIM AND BACKGROUND: The Nordic Liver Transplant Registry (NLTR) accounts for all liver transplants performed in the Nordic countries since the start of the transplant program in 1982. Due to short waiting times, donor liver allocation has been made without considerations of the model of end-stage...

Drugs Approved for Multiple Myeloma

Science.gov (United States)

This page lists cancer drugs approved by the Food and Drug Administration (FDA) for multiple myeloma and other plasma cell neoplasms. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.