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Sample records for nonmuscle tropomyosin resulted

  1. Results of a Phase 1 Dose Escalation Study of Intravesical TMX-101 in Patients with Nonmuscle Invasive Bladder Cancer

    NARCIS (Netherlands)

    Falke, Johannes; Lammers, Rianne J. M.; Arentsen, Harm C.; Ravic, Miroslav; Pozzi, Raffaella; Cornel, Erik B.; Vergunst, Henk; de Reijke, Theo M.; Witjes, J. Alfred

    2013-01-01

    Purpose: Imiquimod, a toll like receptor 7 (TLR-7) agonist, is effective as a topical treatment for skin malignancies. TMX-101 is a liquid formulation of imiquimod. In this study we establish a safety profile of TMX-101 in patients with nonmuscle invasive bladder cancer. Materials and Methods: We

  2. Results of a phase 1 dose escalation study of intravesical TMX-101 in patients with nonmuscle invasive bladder cancer

    NARCIS (Netherlands)

    Falke, J.; Lammers, R.; Arentsen, H.C.; Ravic, M.; Pozzi, R.; Cornel, E.B.; Vergunst, H.; Reijke, T.M. de; Witjes, J.A.

    2013-01-01

    PURPOSE: Imiquimod, a toll like receptor 7 (TLR-7) agonist, is effective as a topical treatment for skin malignancies. TMX-101 is a liquid formulation of imiquimod. In this study we establish a safety profile of TMX-101 in patients with nonmuscle invasive bladder cancer. MATERIALS AND METHODS: We

  3. Structure of a tropomyosin N-terminal fragment at 0.98 Å resolution

    International Nuclear Information System (INIS)

    Meshcheryakov, Vladimir A.; Krieger, Inna; Kostyukova, Alla S.; Samatey, Fadel A.

    2011-01-01

    The crystal structure of the N-terminal fragment of the short nonmuscle α-tropomyosin has been determined at a resolution of 0.98 Å. Tropomyosin (TM) is an elongated two-chain protein that binds along actin filaments. Important binding sites are localized in the N-terminus of tropomyosin. The structure of the N-terminus of the long muscle α-TM has been solved by both NMR and X-ray crystallography. Only the NMR structure of the N-terminus of the short nonmuscle α-TM is available. Here, the crystal structure of the N-terminus of the short nonmuscle α-TM (αTm1bZip) at a resolution of 0.98 Å is reported, which was solved from crystals belonging to space group P3 1 with unit-cell parameters a = b = 33.00, c = 52.03 Å, α = β = 90, γ = 120°. The first five N-terminal residues are flexible and residues 6–35 form an α-helical coiled coil. The overall fold and the secondary structure of the crystal structure of αTM1bZip are highly similar to the NMR structure and the atomic coordinates of the corresponding C α atoms between the two structures superimpose with a root-mean-square deviation of 0.60 Å. The crystal structure validates the NMR structure, with the positions of the side chains being determined precisely in our structure

  4. Radioimmunoassay of human cardiac tropomyosin in acute myocardial infarction

    International Nuclear Information System (INIS)

    Cummins, P.; McGurk, B.; Littler, W.A.

    1981-01-01

    Tropomyosin was prepared from fresh human myocardium and antisera raised in rabbits. A sensitive radioimmunoassay was developed for the detection of human cardiac 125 I-labelled tropomyosin in human sera down to levels of 1 ng/ml. Values for human cardiac tropomyosin in normal patients ranged from less than 1 to 3 ng/ml. In 18 patients with acute myocardial infarction all had elevated tropomyosin levels ranging from 41 to above 200 ng/ml with a mean peak level of 101 ng/ml. In this study there were no false positive or false negative results. In the initial stages of infarction the time course of appearance and peak levels of cardiac tropomyosin, total creatine kinase and creatine kinase MB isoenzyme were similar. Although total creatine kinase and creatine kinase MB isoenzyme levels were normal after 72 h in patients with single, uncomplicated infarction, cardiac tropomyosin levels were still significantly elevated above normal after this time, being 30-60% of peak values. Radioimmunoassay of human cardiac tropomyosin may prove useful in the diagnosis and in the management of patients with acute myocardial infarction, particularly in the long-term postinfarction period. (author)

  5. Radioimmunoassay of human cardiac tropomyosin in acute myocardial infarction

    Energy Technology Data Exchange (ETDEWEB)

    Cummins, P; McGurk, B; Littler, W A [Queen Elizabeth Hospital, Birmingham (UK)

    1981-03-01

    Tropomyosin was prepared from fresh human myocardium and antisera raised in rabbits. A sensitive radioimmunoassay was developed for the detection of human cardiac /sup 125/I-labelled tropomyosin in human sera down to levels of 1 ng/ml. Values for human cardiac tropomyosin in normal patients ranged from less than 1 to 3 ng/ml. In 18 patients with acute myocardial infarction all had elevated tropomyosin levels ranging from 41 to above 200 ng/ml with a mean peak level of 101 ng/ml. In this study there were no false positive or false negative results. In the initial stages of infarction the time course of appearance and peak levels of cardiac tropomyosin, total creatine kinase and creatine kinase MB isoenzyme were similar. Although total creatine kinase and creatine kinase MB isoenzyme levels were normal after 72 h in patients with single, uncomplicated infarction, cardiac tropomyosin levels were still significantly elevated above normal after this time, being 30-60% of peak valuctional hourly rate of absorption and the plasma /sup 32/P radioactivity at 60 min corrected for extracellular fluid volume provided the best app elements, the characteristics of which are determined by employing the Lagrange multiplier concept. Unknowns of the resulting simultaneous equation consist of usual nodal displacements of the whole stru element codes. Therefore, FAST should be useful in several areas for which all other codes are too unwieldy and expensivnt makers was established, in which the investigations and studies have started.

  6. Structure of a tropomyosin N-terminal fragment at 0.98 Å resolution

    Energy Technology Data Exchange (ETDEWEB)

    Meshcheryakov, Vladimir A. [Okinawa Institute of Science and Technology, Okinawa (Japan); Krieger, Inna [Texas A& M University, College Station, Texas (United States); Kostyukova, Alla S. [Robert Wood Johnson Medical School, Piscataway, New Jersey (United States); Samatey, Fadel A., E-mail: f.a.samatey@oist.jp [Okinawa Institute of Science and Technology, Okinawa (Japan)

    2011-09-01

    The crystal structure of the N-terminal fragment of the short nonmuscle α-tropomyosin has been determined at a resolution of 0.98 Å. Tropomyosin (TM) is an elongated two-chain protein that binds along actin filaments. Important binding sites are localized in the N-terminus of tropomyosin. The structure of the N-terminus of the long muscle α-TM has been solved by both NMR and X-ray crystallography. Only the NMR structure of the N-terminus of the short nonmuscle α-TM is available. Here, the crystal structure of the N-terminus of the short nonmuscle α-TM (αTm1bZip) at a resolution of 0.98 Å is reported, which was solved from crystals belonging to space group P3{sub 1} with unit-cell parameters a = b = 33.00, c = 52.03 Å, α = β = 90, γ = 120°. The first five N-terminal residues are flexible and residues 6–35 form an α-helical coiled coil. The overall fold and the secondary structure of the crystal structure of αTM1bZip are highly similar to the NMR structure and the atomic coordinates of the corresponding C{sup α} atoms between the two structures superimpose with a root-mean-square deviation of 0.60 Å. The crystal structure validates the NMR structure, with the positions of the side chains being determined precisely in our structure.

  7. Guard Cell and Tropomyosin Inspired Chemical Sensor

    Directory of Open Access Journals (Sweden)

    Jacquelyn K.S. Nagel

    2013-10-01

    Full Text Available Sensors are an integral part of many engineered products and systems. Biological inspiration has the potential to improve current sensor designs as well as inspire innovative ones. This paper presents the design of an innovative, biologically-inspired chemical sensor that performs “up-front” processing through mechanical means. Inspiration from the physiology (function of the guard cell coupled with the morphology (form and physiology of tropomyosin resulted in two concept variants for the chemical sensor. Applications of the sensor design include environmental monitoring of harmful gases, and a non-invasive approach to detect illnesses including diabetes, liver disease, and cancer on the breath.

  8. Tropomyosin or not tropomyosin, what is the relevant allergen in house dust mite and snail cross allergies?

    Science.gov (United States)

    Bessot, J C; Metz-Favre, C; Rame, J M; De Blay, F; Pauli, G

    2010-02-01

    Since tropomyosin is cross reactive in many arthropods, it was assumed that this highly conserved protein could be responsible for cross reactions in house dust mite (HDM) allergic patients who experienced adverse reactions after crustacean and mollusc ingestion. Here we report two clinical cases where the role of tropomyosin is a matter of debate. In the first case, the clinical history, as well as the results of in vivo and in vitro investigations, are in favour of a shrimp allergy without any snail allergy in a patient sensitized to HDM. In the second, the clinical history and the cutaneous tests are in favour of an allergy to snails without any allergy to shrimps in a patient suffering from HDM allergies. The clinical presentation is different in shrimp and snail allergies. In shrimp allergy, symptoms are mainly urticaria or angio-oedema. In snail allergies, adverse reactions are especially severe asthma. Shrimp tropomyosin is a dominant allergen in crustaceans whereas has a much less prominent role in HDM sensitization. Cross reactivities between HDM and snails have been confirmed by inhibition experiments. However, tropomyosin appears to be a minor allergen or even is not involved in snail allergy. It is necessary to clarify the allergens shared between HDMI and snails. The effects of HDM immunotherapy in snail allergy are questioned. Knowledge of taxonomy can contribute to more precise evaluation of cross reactivities between crustaceans and molluscs.

  9. Tropomyosin-1, a Novel Class II Tumor-Suppressor and a Biomarker of Human Breast Cancer

    National Research Council Canada - National Science Library

    Prasad, Gaddamanugu

    2002-01-01

    .... Downregulation of microfilament-associated proteins, such as tropomyosins (TMs) is hypothesized to result in the formation of functionally aberrant microfilaments, thus contributing to the manifestation of the malignant cells...

  10. Motions of tropomyosin: crystal as metaphor

    Energy Technology Data Exchange (ETDEWEB)

    Phillips, G.N. Jr; Fillers, J.P.; Cohen, C.

    1980-10-01

    Movements of tropomyosin play an essential role in muscle regulation. This fibrous protein is a two-chain ..cap alpha..-helical coiled coil that bonds head to tail to form cables wound in the two long grooves of the actin helix. The regulatory switch consists of tropomyosin and a globular Ca/sup 2 +/ -sensitive protein complex called troponin. The structure of the tropomyosin filaments has now been determined by x-ray crystallography to approx. 15 A resolution. The complete sequence of ..cap alpha..-tropomyosin is known; by using mercury markers on the cysteine residues the ends of the molecules in the filaments have been identified. Details of the coiled-coil structure have also been visualized by refinement of models against the diffraction data. It appears that the molecular filaments fluctuate freely in a direction perpendicular to their axes. Moreover, the C-terminal half of the the molecule unfolds to some degree at less than physiological temperatures. We picture the tropomyosin/troponin switch in muscle as a restless cable, perpetually making and breaking bonds as it vibrates on the thin filament. These movements of tropomyosin probably depend on two aspects of its design: the regular pattern of coiled-coil linkages wth actin; and the aperiodic features that allow flexibility and motion.

  11. Downregulation of tropomyosin-1 in squamous cell carcinoma of esophagus, the role of Ras signaling and methylation.

    Science.gov (United States)

    Zare, Maryam; Jazii, Ferdous Rastgar; Soheili, Zahra-Soheila; Moghanibashi, Mohamad-Mehdi

    2012-10-01

    Tropomyosins (TMs) are a family of cytoskeletal proteins that bind to and stabilize actin microfilaments. Non-muscle cells express multiple isoforms of TMs including three high molecular weight (HMW) isoforms: TM1, TM2, and TM3. While reports have indicated downregulation of TMs in transformed cells and several human cancers, nevertheless, little is known about the underlying mechanism of TMs suppression. In present study the expression of HMW TMs was investigated in squamous cell carcinoma of esophagus (SCCE), relative to primary cell cultures of normal esophagus by western blotting and real-time RT-PCR. Our results showed that TM1, TM2, and TM3 were significantly downregulated in cell line of SCCE. Moreover, mRNA level of TPM1 and TPM2 were markedly decreased by 93% and 96%, in tumor cell line relative to esophagus normal epithelial cells. Therefore, downregulation of TMs could play an important role in tumorigenesis of esophageal cancer. To asses the mechanism of TM downregulation in esophageal cancer, the role of Ras dependent signaling and promoter hypermethylation were investigated. We found that inhibition of two Ras effectory downstream pathways; MEK/ERK and PI3K/Akt leads to significant increased expression of TM1 protein and both TPM1 and TPM2 mRNAs. In addition, methyltransferase inhibition significantly upregulated TM1, suggesting the prominent contribution of promoter hypermethylation in TM1 downregulation in esophageal cancer. These data indicate that downregulation of HMW TMs occurs basically in SCCE and the activation of MEK/ERK and PI3K/Akt pathways as well as the epigenetic mechanism of promoter hypermethylation play important role in TM1 suppression in SCCE. Copyright © 2011 Wiley Periodicals, Inc.

  12. Immunoinformatics and Similarity Analysis of House Dust Mite Tropomyosin

    Directory of Open Access Journals (Sweden)

    Mohammad Mehdi Ranjbar

    2015-10-01

    Full Text Available Background: Dermatophagoides farinae and Dermatophagoides pteronyssinus are house dust mites (HDM that they cause severe asthma and allergic symptoms. Tropomyosin protein plays an important role in mentioned immune and allergic reactions to HDMs. Here, tropomyosin protein from Dermatophagoides spp. was comprehensively screened in silico for its allergenicity, antigenicity and similarity/conservation.Materials and Methods: The amino acid sequences of D. farinae tropomyosin, D. pteronyssinus and other mites were retrieved. We included alignments and evaluated conserved/ variable regions along sequences, constructed their phylogenetic tree and estimated overall mean distances. Then, followed by with prediction of linear B-cell epitope based on different approaches, and besides in-silico evaluation of IgE epitopes allergenicity (by SVMc, IgE epitope, ARPs BLAST, MAST and hybrid method. Finally, comparative analysis of results by different approaches was made.Results: Alignment results revealed near complete identity between D. farina and D. pteronyssinus members, and also there was close similarity among Dermatophagoides spp. Most of the variations among mites' tropomyosin were approximately located at amino acids 23 to 80, 108 to 120, 142 to 153 and 220 to 230. Topology of tree showed close relationships among mites in tropomyosin protein sequence, although their sequences in D. farina, D. pteronyssinus and Psoroptes ovis are more similar to each other and clustered. Dermanyssus gallinae (AC: Q2WBI0 has less relationship to other mites, being located in a separate branch. Hydrophilicity and flexibility plots revealed that many parts of this protein have potential to be hydrophilic and flexible. Surface accessibility represented 7 different epitopes. Beta-turns in this protein are with high probability in the middle part and its two terminals. Kolaskar and Tongaonkar method analysis represented 11 immunogenic epitopes between amino acids 7-16. From

  13. Immunization with Hypoallergens of shrimp allergen tropomyosin inhibits shrimp tropomyosin specific IgE reactivity.

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    Christine Y Y Wai

    Full Text Available Designer proteins deprived of its IgE-binding reactivity are being sought as a regimen for allergen-specific immunotherapy. Although shrimp tropomyosin (Met e 1 has long been identified as the major shellfish allergen, no immunotherapy is currently available. In this study, we aim at identifying the Met e 1 IgE epitopes for construction of hypoallergens and to determine the IgE inhibitory capacity of the hypoallergens. IgE-binding epitopes were defined by three online computational models, ELISA and dot-blot using sera from shrimp allergy patients. Based on the epitope data, two hypoallergenic derivatives were constructed by site-directed mutagenesis (MEM49 and epitope deletion (MED171. Nine regions on Met e 1 were defined as the major IgE-binding epitopes. Both hypoallergens MEM49 and MED171 showed marked reduction in their in vitro reactivity towards IgE from shrimp allergy patients and Met e 1-sensitized mice, as well as considerable decrease in induction of mast cell degranulation as demonstrated in passive cutaneous anaphylaxis assay. Both hypoallergens were able to induce Met e 1-recognizing IgG antibodies in mice, specifically IgG2a antibodies, that strongly inhibited IgE from shrimp allergy subjects and Met e 1-sensitized mice from binding to Met e 1. These results indicate that the two designer hypoallergenic molecules MEM49 and MED171 exhibit desirable preclinical characteristics, including marked reduction in IgE reactivity and allergenicity, as well as ability to induce blocking IgG antibodies. This approach therefore offers promises for development of immunotherapeutic regimen for shrimp tropomyosin allergy.

  14. Tropomyosin Receptor Kinase A Expression on Merkel Cell Carcinoma Cells.

    Science.gov (United States)

    Wehkamp, Ulrike; Stern, Sophie; Krüger, Sandra; Hauschild, Axel; Röcken, Christoph; Egberts, Friederike

    2017-11-01

    Merkel cell carcinoma (MCC) is a malignant neuroendocrine skin tumor frequently associated with the Merkel cell polyomavirus. Immune checkpoint therapy showed remarkable results, although not all patients are responsive to this therapy. Anti-tropomyosin receptor kinase A (TrkA)-targeted treatment has shown promising results in several tumor entities. To determine TrkA expression in MCC as a rationale for potential targeted therapy. This case series study investigated the MCC specimens of 55 patients treated at the Department of Dermatology, University Hospital of Schleswig-Holstein, Kiel, Germany, from January 1, 2005, through December 31, 2015. Thirty-nine of the 55 samples were suitable for further histopathologic examination. Expression of TrkA was explored by immunohistochemical analysis. Diagnosis of MCC was confirmed by staining positive for cytokeratin 20 (CK20) and synaptophysin. Expression of TrkA on the tumor cells. Specimens of 39 patients (21 women and 18 men; mean [SD] age, 75.0 [7.8] years) underwent immunohistochemical investigation. Thirty-eight of 38 specimens expressed CK20 and synaptophysin on the MCC tumor cells (100% expression). Merkel cell polyomavirus was detected in 32 of 38 specimens (84%). Tropomyosin receptor kinase A was found in all 36 evaluable specimens on the tumor cells; 34 (94%) showed a weak and 2 (6%) showed a strong cytoplasmic expression. In addition, strongly positive perinuclear dots were observed in 30 of 36 specimens (83%). Tropomyosin receptor kinase A was expressed on MCC tumor cells in 100% of evaluable specimens. This result may lead to the exploration of new targeted treatment options in MCC, especially for patients who do not respond to anti-programmed cell death protein 1 treatment.

  15. Anti-adhesive properties of fish tropomyosins

    DEFF Research Database (Denmark)

    Vejborg, Rebecca Munk; Bernbom, Nete; Gram, Lone

    2008-01-01

    Aims: We have recently found that preconditioning of stainless steel surfaces with an aqueous fish muscle extract can significantly impede bacterial adhesion. The purpose of this study was to identify and characterize the primary components associated with this bacteria-repelling effect. Methods...... to the formation of a proteinaceous conditioning film composed primarily of fish tropomyosins. These fibrous proteins formed a considerable anti-adhesive conditioning layer on and reduced bacterial adhesion to several different materials including polystyrene, vinyl plastic, stainless steel and glass. The protein...... the importance of substratum's physiochemical properties and exposure time with regards to protein adsorption/elution efficiency and subsequent bacterial adhesion. Significance and Impact of the Study: Fish tropomyosin-coatings could potentially offer a nontoxic and relatively inexpensive measure of reducing...

  16. Allergenicity of vertebrate tropomyosins: Challenging an immunological dogma.

    Science.gov (United States)

    González-Fernández, J; Daschner, A; Cuéllar, C

    With the exception of tilapia tropomyosin, other anecdotic reports of tropomyosin recognition of vertebrate origin are generally not accompanied by clinical significance and a dogmatic idea is generally accepted about the inexistence of allergenicity of vertebrate tropomyosins, based mainly on sequence similarity evaluations with human tropomyosins. Recently, a specific work-up of a tropomyosin sensitised patient with seafood allergy, demonstrated that the IgE-recognition of tropomyosin from different fish species can be clinically relevant. We hypothesise that some vertebrate tropomyosins could be relevant allergens. The hypothesis is based on the molecular evolution of the proteins and it was tested by in silico methods. Fish, which are primitive vertebrates, could have tropomyosins similar to those of invertebrates. If the hypothesis is confirmed, tropomyosin should be included in different allergy diagnosis tools to improve the medical protocols and management of patients with digestive or cutaneous symptoms after fish intake. Copyright © 2016 SEICAP. Published by Elsevier España, S.L.U. All rights reserved.

  17. Nonmuscle Tissues Contribution to Cancer Cachexia

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    Josep M. Argilés

    2015-01-01

    Full Text Available Cachexia is a syndrome associated with cancer, characterized by body weight loss, muscle and adipose tissue wasting, and inflammation, being often associated with anorexia. In spite of the fact that muscle tissue represents more than 40% of body weight and seems to be the main tissue involved in the wasting that occurs during cachexia, recent developments suggest that tissues/organs such as adipose (both brown and white, brain, liver, gut, and heart are directly involved in the cachectic process and may be responsible for muscle wasting. This suggests that cachexia is indeed a multiorgan syndrome. Bearing all this in mind, the aim of the present review is to examine the impact of nonmuscle tissues in cancer cachexia.

  18. Tropomodulins and tropomyosins - organizers of cellular microcompartments.

    Science.gov (United States)

    Fath, Thomas

    2013-02-01

    Eukaryotic cells show a remarkable compartmentalization into compartments such as the cell nucleus, the Golgi apparatus, the endoplasmic reticulum, and endosomes. However, organelle structures are not the only means by which specialized compartments are formed. Recent research shows a critical role for diverse actin filament populations in defining functional compartments, here referred to as microcompartments, in a wide range of cells. These microcompartments are involved in regulating fundamental cellular functions including cell motility, plasma membrane organization, and cellular morphogenesis. In this overview, the importance of two multigene families of actin-associated proteins, tropomodulins and tropomyosins, their interactions with each other, and a large number of other proteins will be discussed in the context of generating specialized actin-based microcompartments.

  19. INITIAL EXPERIENCE WITH ADJUVANT INTRAVESICAL THERMOCHEMOTHERAPY FOR NON-MUSCLE INVASIVE BLADDER CANCER

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    K. A. Pavlenko

    2011-01-01

    Full Text Available Objective: to reveal the benefits of adjuvant intravesical thermochemotherapy (TCT and to evaluate its efficiency in the treatment of moderateand high-risk non-muscle invasive bladder cancer (BC.Subjects and methods. In the period 2009 to 2010, the Urology Clinic, Federal Medical Biophysical Center, treated 21 patients with nonmuscle invasive BC, by using a Thermotron RF-8 clinical hyperthermal system. Intravesical TCT with mitomycin C 40 mg for 60–80 min was performed at 42 ± 2 °С as one session weekly for 6 weeks. Control cystoscopy was carried out every 3 months.Results. Of the 21 patients, 19 were found to tolerate the procedure well. No complications were recorded in these patients during the sessions and throughout the course of intravesical TCT. A recurrence was histologically verified in 2 patients at 6-month follow-up. There was no evidence suggesting a recurrence in 12 (57.14 % patients at one-year follow-up. The follow-up of the other patients is now less than 12 months.Conclusion. The proposed method of hyperthermia may be used as an alternative to the existing one of intracavitary hyperthermia to treat high- and moderate-risk BC and in case of inefficiency of other adjuvant therapy options for non-muscle invasive BC.

  20. Myofibril-Inducing RNA (MIR is essential for tropomyosin expression and myofibrillogenesis in axolotl hearts

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    Lemanski Sharon L

    2009-09-01

    Full Text Available Abstract The Mexican axolotl, Ambystoma mexicanum, carries the naturally-occurring recessive mutant gene 'c' that results in a failure of homozygous (c/c embryos to form hearts that beat because of an absence of organized myofibrils. Our previous studies have shown that a noncoding RNA, Myofibril-Inducing RNA (MIR, is capable of promoting myofibrillogenesis and heart beating in the mutant (c/c axolotls. The present study demonstrates that the MIR gene is essential for tropomyosin (TM expression in axolotl hearts during development. Gene expression studies show that mRNA expression of various tropomyosin isoforms in untreated mutant hearts and in normal hearts knocked down with double-stranded MIR (dsMIR are similar to untreated normal. However, at the protein level, selected tropomyosin isoforms are significantly reduced in mutant and dsMIR treated normal hearts. These results suggest that MIR is involved in controlling the translation or post-translation of various TM isoforms and subsequently of regulating cardiac contractility.

  1. Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle.

    Science.gov (United States)

    Vlahovich, Nicole; Schevzov, Galina; Nair-Shaliker, Visalini; Ilkovski, Biljana; Artap, Stanley T; Joya, Josephine E; Kee, Anthony J; North, Kathryn N; Gunning, Peter W; Hardeman, Edna C

    2008-01-01

    The organisation of structural proteins in muscle into highly ordered sarcomeres occurs during development, regeneration and focal repair of skeletal muscle fibers. The involvement of cytoskeletal proteins in this process has been documented, with nonmuscle gamma-actin found to play a role in sarcomere assembly during muscle differentiation and also shown to be up-regulated in dystrophic muscles which undergo regeneration and repair [Lloyd et al.,2004; Hanft et al.,2006]. Here, we show that a cytoskeletal tropomyosin (Tm), Tm4, defines actin filaments in two novel compartments in muscle fibers: a Z-line associated cytoskeleton (Z-LAC), similar to a structure we have reported previously [Kee et al.,2004], and longitudinal filaments that are orientated parallel to the sarcomeric apparatus, present during myofiber growth and repair/regeneration. Tm4 is upregulated in paradigms of muscle repair including induced regeneration and focal repair and in muscle diseases with repair/regeneration features, muscular dystrophy and nemaline myopathy. Longitudinal Tm4-defined filaments also are present in diseased muscle. Transition of the Tm4-defined filaments from a longitudinal to a Z-LAC orientation is observed during the course of muscle regeneration. This Tm4-defined cytoskeleton is a marker of growth and repair/regeneration in response to injury, disease state and stress in skeletal muscle.

  2. Perioperative management of nonmuscle-invasive bladder cancer

    NARCIS (Netherlands)

    Falke, J.; Witjes, J.A.

    2011-01-01

    PURPOSE OF REVIEW: The management of nonmuscle-invasive bladder cancer is a challenge. Despite current guidelines, the treatment is suboptimal as illustrated by the high risk of recurrence and progression. Transurethral resection plays a pivotal role in the management of bladder cancer, but the

  3. Shrimp Tropomyosin Retains Antibody Reactivity after Exposure to Acidic Conditions

    Science.gov (United States)

    Although shrimp can be found in certain high acid food matrices, the allergenic capacity of shrimp tropomyosin exposed to low pH condition has not been fully clarified. Thus, a model marinade comprising white vinegar adjusted to different pH was used to determine the effects of acid-induced denatura...

  4. Tetratricopeptide repeat domain 9A is an interacting protein for tropomyosin Tm5NM-1

    International Nuclear Information System (INIS)

    Cao, Shenglan; Ho, Gay Hui; Lin, Valerie CL

    2008-01-01

    Tetratricopeptide repeat domain 9A (TTC9A) protein is a recently identified protein which contains three tetratricopeptide repeats (TPRs) on its C-terminus. In our previous studies, we have shown that TTC9A was a hormonally-regulated gene in breast cancer cells. In this study, we found that TTC9A was over-expressed in breast cancer tissues compared with the adjacent controls (P < 0.00001), suggesting it might be involved in the breast cancer development process. The aim of the current study was to further elucidate the function of TTC9A. Breast samples from 25 patients including the malignant breast tissues and the adjacent normal tissues were processed for Southern blot analysis. Yeast-two-hybrid assay, GST pull-down assay and co-immunoprecipitation were used to identify and verify the interaction between TTC9A and other proteins. Tropomyosin Tm5NM-1 was identified as one of the TTC9A partner proteins. The interaction between TTC9A and Tm5NM-1 was further confirmed by GST pull-down assay and co-immunoprecipitation in mammalian cells. TTC9A domains required for the interaction were also characterized in this study. The results suggested that the first TPR domain and the linker fragment between the first two TPR domains of TTC9A were important for the interaction with Tm5NM-1 and the second and the third TPR might play an inhibitory role. Since the primary function of tropomyosin is to stabilize actin filament, its interaction with TTC9A may play a role in cell shape and motility. In our previous results, we have found that progesterone-induced TTC9A expression was associated with increased cell motility and cell spreading. We speculate that TTC9A acts as a chaperone protein to facilitate the function of tropomyosins in stabilizing microfilament and it may play a role in cancer cell invasion and metastasis

  5. Natural biology and management of nonmuscle invasive bladder cancer

    DEFF Research Database (Denmark)

    Scarpato, Kristen R; Tyson, Mark D; Clark, Peter E

    2016-01-01

    PURPOSE OF REVIEW: This article reviews the natural biology of noninvasive bladder cancer and its management strategies while summarizing the most recent advances in the field. RECENT FINDINGS: Nonmuscle invasive bladder cancer (NMIBC) has a tendency to recur and progress. Risk stratification has...... in low-risk patients. SUMMARY: NMIBC represents a variety of disease states and continues to pose management challenges. As our understanding of tumor biology improves and technology advances, achieving better outcomes through individualized care may be possible.......PURPOSE OF REVIEW: This article reviews the natural biology of noninvasive bladder cancer and its management strategies while summarizing the most recent advances in the field. RECENT FINDINGS: Nonmuscle invasive bladder cancer (NMIBC) has a tendency to recur and progress. Risk stratification has...... helped triage patients but improved tools, including biomarkers, are still needed. Enhanced endoscopy with photodynamic imaging, narrow band imaging, optical coherence tomography and confocal laser endomicroscopy show promise for diagnosis, risk stratification and disease monitoring. Attempts at better...

  6. A peek into tropomyosin binding and unfolding on the actin filament.

    Directory of Open Access Journals (Sweden)

    Abhishek Singh

    Full Text Available BACKGROUND: Tropomyosin is a prototypical coiled coil along its length with subtle variations in structure that allow interactions with actin and other proteins. Actin binding globally stabilizes tropomyosin. Tropomyosin-actin interaction occurs periodically along the length of tropomyosin. However, it is not well understood how tropomyosin binds actin. PRINCIPAL FINDINGS: Tropomyosin's periodic binding sites make differential contributions to two components of actin binding, cooperativity and affinity, and can be classified as primary or secondary sites. We show through mutagenesis and analysis of recombinant striated muscle alpha-tropomyosins that primary actin binding sites have a destabilizing coiled-coil interface, typically alanine-rich, embedded within a non-interface recognition sequence. Introduction of an Ala cluster in place of the native, more stable interface in period 2 and/or period 3 sites (of seven increased the affinity or cooperativity of actin binding, analysed by cosedimentation and differential scanning calorimetry. Replacement of period 3 with period 5 sequence, an unstable region of known importance for cooperative actin binding, increased the cooperativity of binding. Introduction of the fluorescent probe, pyrene, near the mutation sites in periods 2 and 3 reported local instability, stabilization by actin binding, and local unfolding before or coincident with dissociation from actin (measured using light scattering, and chain dissociation (analyzed using circular dichroism. CONCLUSIONS: This, and previous work, suggests that regions of tropomyosin involved in binding actin have non-interface residues specific for interaction with actin and an unstable interface that is locally stabilized upon binding. The destabilized interface allows residues on the coiled-coil surface to obtain an optimal conformation for interaction with actin by increasing the number of local substates that the side chains can sample. We suggest

  7. Nonmuscle myosin IIB as a therapeutic target for the prevention of relapse to methamphetamine use

    Science.gov (United States)

    Young, Erica J.; Blouin, Ashley M.; Briggs, Sherri B.; Sillivan, Stephanie E.; Lin, Li; Cameron, Michael D.; Rumbaugh, Gavin; Miller, Courtney A.

    2015-01-01

    Memories associated with drug use increase vulnerability to relapse in substance use disorder (SUD) and there are no pharmacotherapies for the prevention of relapse. Previously, we reported a promising finding that storage of memories associated with methamphetamine (METH), but not memories for fear or food reward, is vulnerable to disruption by actin depolymerization in the basolateral amygdala complex (BLC). However, actin is not a viable therapeutic target because of its numerous functions throughout the body. Here we report the discovery of a viable therapeutic target, nonmuscle myosin II (NMIIB), a molecular motor that supports memory by directly driving synaptic actin polymerization. A single intra-BLC treatment with Blebbistatin, a small molecule inhibitor of class II myosin isoforms, including NMIIB, produced a long-lasting disruption of context-induced drug seeking (at least 30 days). Further, post-consolidation genetic knockdown of Myh10, the heavy chain of the most highly expressed NMII in the BLC, was sufficient to produce METH-associated memory loss. Blebbistatin was found to be highly brain penetrant. A single systemic injection of the compound selectively disrupted the storage of METH-associated memory and reversed the accompanying increase in BLC spine density. This effect was specific to METH-associated memory, as it had no effect on an auditory fear memory. The effect was also independent of retrieval, as METH-associated memory was disrupted twenty-four hours after a single systemic injection of Blebbistatin delivered in the home cage. Together, these results argue for the further development of small molecule inhibitors of nonmuscle myosin II as potential therapeutics for the prevention of SUD relapse triggered by drug associations. PMID:26239291

  8. Expression of various sarcomeric tropomyosin isoforms in equine striated muscles

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    Syamalima Dube

    2017-06-01

    Full Text Available In order to better understand the training and athletic activity of horses, we must have complete understanding of the isoform diversity of various myofibrillar protein genes like tropomyosin. Tropomyosin (TPM, a coiled-coil dimeric protein, is a component of thin filament in striated muscles. In mammals, four TPM genes (TPM1, TPM2, TPM3, and TPM4 generate a multitude of TPM isoforms via alternate splicing and/or using different promoters. Unfortunately, our knowledge of TPM isoform diversity in the horse is very limited. Hence, we undertook a comprehensive exploratory study of various TPM isoforms from horse heart and skeletal muscle. We have cloned and sequenced two sarcomeric isoforms of the TPM1 gene called TPM1α and TPM1κ, one sarcomeric isoform of the TPM2 and one of the TPM3 gene, TPM2α and TPM3α respectively. By qRT-PCR using both relative expression and copy number, we have shown that TPM1α expression compared to TPM1κ is very high in heart. On the other hand, the expression of TPM1α is higher in skeletal muscle compared to heart. Further, the expression of TPM2α and TPM3α are higher in skeletal muscle compared to heart. Using western blot analyses with CH1 monoclonal antibody we have shown the high expression levels of sarcomeric TPM proteins in cardiac and skeletal muscle. Due to the paucity of isoform specific antibodies we cannot specifically detect the expression of TPM1κ in horse striated muscle. To the best of our knowledge this is the very first report on the characterization of sarcmeric TPMs in horse striated muscle.

  9. Defining progression in nonmuscle invasive bladder cancer: it is time for a new, standard definition.

    Science.gov (United States)

    Lamm, Donald; Persad, Raj; Brausi, Maurizio; Buckley, Roger; Witjes, J Alfred; Palou, Joan; Böhle, Andreas; Kamat, Ashish M; Colombel, Marc; Soloway, Mark

    2014-01-01

    Despite being one of the most important clinical outcomes in nonmuscle invasive bladder cancer, there is currently no standard definition of disease progression. Major clinical trials and meta-analyses have used varying definitions or have failed to define this end point altogether. A standard definition of nonmuscle invasive bladder cancer progression as determined by reproducible and reliable procedures is needed. We examine current definitions of nonmuscle invasive bladder cancer progression, and propose a new definition that will be more clinically useful in determining patient prognosis and comparing treatment options. The IBCG (International Bladder Cancer Group) analyzed published clinical trials and meta-analyses that examined nonmuscle invasive bladder cancer progression as of December 2012. The limitations of the definitions of progression used in these trials were considered, as were additional parameters associated with the advancement of nonmuscle invasive bladder cancer. The most commonly used definition of nonmuscle invasive bladder cancer progression is an increase in stage from nonmuscle invasive to muscle invasive disease. Although this definition is clinically important, it fails to include other important parameters of advancing disease such as progression to lamina propria invasion and increase in grade. The IBCG proposes the definition of nonmuscle invasive bladder cancer progression as an increase in T stage from CIS or Ta to T1 (lamina propria invasion), development of T2 or greater or lymph node (N+) disease or distant metastasis (M1), or an increase in grade from low to high. Investigators should consider the use of this new definition to help standardize protocols and improve the reporting of progression. Copyright © 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  10. Risk prediction scores for recurrence and progression of non-muscle invasive bladder cancer : An international validation in primary tumours

    NARCIS (Netherlands)

    M.M. Vedder (Moniek); M. Márquez (Mirari); E.W. de Bekker-Grob (Esther); M.L. Calle (Malu); L. Dyrskjot (Lars); M. Kogevinas (Manolis); U. Segersten (Ulrika); P.-U. Malmström (Per-Uno); F. Algaba (Ferran); W. Beukers (Willemien); T.F. Orntoft (Torben); E.C. Zwarthoff (Ellen); F.X. Real (Francisco); N. Malats (Núria); E.W. Steyerberg (Ewout)

    2014-01-01

    textabstractObjective: We aimed to determine the validity of two risk scores for patients with non-muscle invasive bladder cancer in different European settings, in patients with primary tumours. Methods: We included 1,892 patients with primary stage Ta or T1 non-muscle invasive bladder cancer who

  11. Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling

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    Lorenzo Rakesh Sewanan

    2016-10-01

    Full Text Available Point mutations to the human gene TPM1 have been implicated in the development of both hypertrophic and dilated cardiomyopathies. Such observations have led to studies investigating the link between single residue changes and the biophysical behavior of the tropomyosin molecule. However, the degree to which these molecular perturbations explain the performance of intact sarcomeres containing mutant tropomyosin remains uncertain. Here, we present a modeling approach that integrates various aspects of tropomyosin’s molecular properties into a cohesive paradigm representing their impact on muscle function. In particular, we considered the effects of tropomyosin mutations on (1 persistence length, (2 equilibrium between thin filament blocked and closed regulatory states, and (3 the crossbridge duty cycle. After demonstrating the ability of the new model to capture Ca-dependent myofilament responses during both dynamic and steady-state activation, we used it to capture the effects of hypertrophic cardiomyopathy (HCM related E180G and D175N mutations on skinned myofiber mechanics. Our analysis indicates that the fiber-level effects of the two mutations can be accurately described by a combination of changes to the three tropomyosin properties represented in the model. Subsequently, we used the model to predict mutation effects on muscle twitch. Both mutations led to increased twitch contractility as a consequence of diminished cooperative inhibition between thin filament regulatory units. Overall, simulations suggest that a common twitch phenotype for HCM-linked tropomyosin mutations includes both increased contractility and elevated diastolic tension.

  12. Defining Priorities to Improve Patient Experience in Non-Muscle Invasive Bladder Cancer.

    Science.gov (United States)

    Garg, Tullika; Connors, Jill Nault; Ladd, Ilene G; Bogaczyk, Tyler L; Larson, Sharon L

    2018-01-20

    Although approximately 75% of bladder cancers are non-muscle invasive (NMIBC) at diagnosis, most research tends to focus on invasive disease (e.g., experiences related to radical cystectomy and urinary diversion). There is a lack of studies on quality of life, and especially qualitative research, in bladder cancer generally. As a result, relatively little is known about the experiences and needs of NMIBC patients. To understand patient experience, define care priorities, and identify targets for care improvement in NMIBC across the cancer continuum. Through focus groups, patients treated for NMIBC (stage influences on decision-making, and role of social support. Patients with NMIBC desired timely access to care and honest and caring provider communication. They described urinary function and emotional quality of life changes resulting from diagnosis and treatment. Avoiding cystectomy and being alive for family were the major decision influencers. In this qualitative study, we identified access to care, provider characteristics and communication, quality of life, values/influences on decision-making, and social support as priority areas to improve patient experience in NMIBC. Care redesign efforts should focus on improving access, enhancing provider communication, reducing side effects, and supporting caregiver roles.

  13. Guideline-based management of non-muscle invasive bladder cancer

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    Justin R Gregg

    2015-01-01

    Full Text Available Introduction: Non-muscle invasive bladder cancer (NMIBC represents a broad spectrum of disease, the hallmarks of which include disease recurrence and progression. Clinicians have a number of surgical and therapeutic options at their disposal when treating this disease, and the underlying evidence continues to evolve. A number of professional organizations have invested in the development of clinical practice guidelines to guide patient management. Materials and Methods: We review and summarize four major guidelines, the American Urological Association, the European Association of Urology, the International Consultation on Urological Disease and the National Comprehensive Cancer Network. Results: Guideline panels differed in their composition, methodological approach and structure of recommendations. Despite this, many recommendations were similar between various panels, although differences are present in panel recommendations related to initial diagnosis and treatment, adjuvant therapy and disease surveillance. Conclusions: Guideline recommendations are similar at many decision points that clinicians face when managing NMIBC, although they are far from uniform. While future prospective, well-designed studies will hopefully clarify NMIBC management, urologists ultimately must rely on a combination of evidence-based recommendations, which they should seek to integrate with patients' values and preferences and the individual circumstances to provide the best possible patient care.

  14. Comprehensive analysis of tropomyosin isoforms in skeletal muscles by top-down proteomics.

    Science.gov (United States)

    Jin, Yutong; Peng, Ying; Lin, Ziqing; Chen, Yi-Chen; Wei, Liming; Hacker, Timothy A; Larsson, Lars; Ge, Ying

    2016-04-01

    Mammalian skeletal muscles are heterogeneous in nature and are capable of performing various functions. Tropomyosin (Tpm) is a major component of the thin filament in skeletal muscles and plays an important role in controlling muscle contraction and relaxation. Tpm is known to consist of multiple isoforms resulting from different encoding genes and alternative splicing, along with post-translational modifications. However, a systematic characterization of Tpm isoforms in skeletal muscles is still lacking. Therefore, we employed top-down mass spectrometry (MS) to identify and characterize Tpm isoforms present in different skeletal muscles from multiple species, including swine, rat, and human. Our study revealed that Tpm1.1 and Tpm2.2 are the two major Tpm isoforms in swine and rat skeletal muscles, whereas Tpm1.1, Tpm2.2, and Tpm3.12 are present in human skeletal muscles. Tandem MS was utilized to identify the sequences of the major Tpm isoforms. Furthermore, quantitative analysis revealed muscle-type specific differences in the abundance of un-modified and modified Tpm isoforms in rat and human skeletal muscles. This study represents the first systematic investigation of Tpm isoforms in skeletal muscles, which not only demonstrates the capabilities of top-down MS for the comprehensive characterization of skeletal myofilament proteins but also provides the basis for further studies on these Tpm isoforms in muscle-related diseases.

  15. Can we improve transurethral resection of the bladder tumour for nonmuscle invasive bladder cancer?

    NARCIS (Netherlands)

    Liem, Esmee Iml; de Reijke, Theo M.

    2017-01-01

    Purpose of review The recurrence rate in patients with nonmuscle invasive bladder cancer is high, and the quality of transurethral resection of the bladder (TURB) tumour influences recurrence risk. We review new methods that aim to improve the effectiveness of TURB, and highlight studies of the past

  16. Defining progression in nonmuscle invasive bladder cancer: it is time for a new, standard definition

    NARCIS (Netherlands)

    Lamm, D.; Persad, R.; Brausi, M.; Buckley, R.; Witjes, J.A.; Palou, J.; Bohle, A.; Kamat, A.M.; Colombel, M.; Soloway, M.

    2014-01-01

    PURPOSE: Despite being one of the most important clinical outcomes in nonmuscle invasive bladder cancer, there is currently no standard definition of disease progression. Major clinical trials and meta-analyses have used varying definitions or have failed to define this end point altogether. A

  17. Defining and treating the spectrum of intermediate risk nonmuscle invasive bladder cancer

    NARCIS (Netherlands)

    Kamat, A.M.; Witjes, J.A.; Brausi, M.; Soloway, M.; Lamm, D.; Persad, R.; Buckley, R.; Bohle, A.; Colombel, M.; Palou, J.

    2014-01-01

    PURPOSE: Low, intermediate and high risk categories have been defined to help guide the treatment of patients with nonmuscle invasive bladder cancer (Ta, T1, CIS). However, while low and high risk disease has been well classified, the intermediate risk category has traditionally comprised a

  18. Evolutionarily conserved sites in yeast tropomyosin function in cell polarity, transport and contractile ring formation

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    Susanne Cranz-Mileva

    2015-08-01

    Full Text Available Tropomyosin is a coiled-coil protein that binds and regulates actin filaments. The tropomyosin gene in Schizosaccharomyces pombe, cdc8, is required for formation of actin cables, contractile rings, and polar localization of actin patches. The roles of conserved residues were investigated in gene replacement mutants. The work validates an evolution-based approach to identify tropomyosin functions in living cells and sites of potential interactions with other proteins. A cdc8 mutant with near-normal actin affinity affects patch polarization and vacuole fusion, possibly by affecting Myo52p, a class V myosin, function. The presence of labile residual cell attachments suggests a delay in completion of cell division and redistribution of cell patches following cytokinesis. Another mutant with a mild phenotype is synthetic negative with GFP-fimbrin, inferring involvement of the mutated tropomyosin sites in interaction between the two proteins. Proteins that assemble in the contractile ring region before actin do so in a mutant cdc8 strain that cannot assemble condensed actin rings, yet some cells can divide. Of general significance, LifeAct-GFP negatively affects the actin cytoskeleton, indicating caution in its use as a biomarker for actin filaments.

  19. Molecular cloning and the allergenic characterization of tropomyosin from Tyrophagus putrescentiae.

    Science.gov (United States)

    Jeong, Kyoung Yong; Lee, Haeseok; Lee, Jae Sik; Lee, Jongweon; Lee, In-Yong; Ree, Han-Il; Hong, Chein-Soo; Yong, Tai-Soon

    2007-01-01

    Storage mites have been recognized as a cause of asthma and rhinitis. Studies from several countries have shown that the IgE-mediated allergy to storage mites is of considerable importance, especially in rural populations. This study aimed to identify and characterize new allergens from Tyrophagus putrescentiae. A partial cDNA sequence encoding tropomyosin was isolated from the cDNA library by immunoscreening using anti-mouse IgG1 sera raised against T. putrescentiae whole body extract. The deduced amino acid sequence shares 64-94% identity with previously known allergenic tropomyosins. Its recombinant protein was produced by using a pET 28b expression system and purified by affinity chromatography using Ni-NTA agarose. The IgE reactivities of tropomyosins from T. putrescentiae and Dermatophagoides farinae were compared by enzyme linked immunosorbent assay (ELISA). Recombinant Tyr p 10 showed 12.5% (5/40) IgE-binding reactivity, whereas recombinant Der f 10 showed 25% (10/40) IgE-binding reactivity against the same sera from storage mite-sensitized and house dust mite-sensitized subjects. Both recombinant Tyr p 10 and Der f 10 showed little inhibition of IgE binding to T. putrescentiae crude extract by ELISA. Tropomyosin seems to contribute only a small portion of the cross-reactivity with house dust mites.

  20. Clinical significance of serum and urinary HER2/neu protein levels in primary non-muscle invasive bladder cancer

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    Ozgur Arikan

    2015-12-01

    Full Text Available Objective: We aimed to compare serum and urinary HER2/neu levels between healthy control group and patients with non-muscle invasive bladder cancer. Additionally, we evaluated relationship of HER2/neu levels with tumor stage, grade, recurrence and progression. Materials and Methods: Fourty-four patients with primary non-muscle invasive bladder tumors (Group 2 and 40 healthy control group (Group 1 were included the study. Blood and urinary samples were collected from all patients and HER2/neu levels were measured by ELISA method. Blood and urinary HER2/neu levels and additionally, ratio of urinary HER2/neu levels to urinary creatinine levels were recorded. Demographic data and tumor characteristics were recorded. Results: Mean serum HER2/neu levels were similar between two groups and statistically significant difference wasn't observed. Urinary HER2/neu levels were significantly higher in group 2 than group 1. Ratio of urinary HER2/neu to urinary creatinine was significantly higher in group 2 than group 1, (p=0,021. Serum and urinary HER2/ neu levels were not associated with tumor stage, grade, recurrence and progression while ratio of urinary HER2/neu to urinary creatinin levels were significantly higher in high-grade tumors. HER2/neu, the sensitivity of the test was found to be 20.5%, and the specificity was 97.5%, also for the urinary HER2/neu/urinary creatinine ratio, the sensitivity and specificity of the test were found to be 31.8% and 87.5%, respectively. Conclusions: Urinary HER2/neu and ratio of urinary creatinine urine were significantly higher in patients with bladder cancer compared to healthy subjects. Large series and controlled studies are needed for use as a tumor marker.

  1. Novel multisensor probe for monitoring bladder temperature during locoregional chemohyperthermia for nonmuscle-invasive bladder cancer: technical feasibility study

    NARCIS (Netherlands)

    Cordeiro, Ernesto R.; Geijsen, Debby E.; Zum Vörde Sive Vörding, Paul J.; Schooneveldt, Gerben; Sijbrands, Jan; Hulshof, Maarten C.; de la Rosette, Jean; de Reijke, Theo M.; Crezee, Hans

    2013-01-01

    The effectiveness of locoregional hyperthermia combined with intravesical instillation of mitomycin C to reduce the risk of recurrence and progression of intermediate- and high-risk nonmuscle-invasive bladder cancer is currently investigated in clinical trials. Clinically effective locoregional

  2. Regulation of nonmuscle myosin II during 3-methylcholanthrene induced dedifferentiation of C2C12 myotubes

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    Dey, Sumit K.; Saha, Shekhar; Das, Provas; Das, Mahua R.; Jana, Siddhartha S., E-mail: bcssj@iacs.res.in

    2014-08-01

    3-Methylcholanthrene (3MC) induces tumor formation at the site of injection in the hind leg of mice within 110 days. Recent reports reveal that the transformation of normal muscle cells to atypical cells is one of the causes for tumor formation, however the molecular mechanism behind this process is not well understood. Here, we show in an in vitro study that 3MC induces fragmentation of multinucleate myotubes into viable mononucleates. These mononucleates form colonies when they are seeded into soft agar, indicative of cellular transformation. Immunoblot analysis reveals that phosphorylation of myosin regulatory light chain (RLC{sub 20}) is 5.6±0.5 fold reduced in 3MC treated myotubes in comparison to vehicle treated myotubes during the fragmentation of myotubes. In contrast, levels of myogenic factors such as MyoD, Myogenin and cell cycle regulators such as Cyclin D, Cyclin E1 remain unchanged as assessed by real-time PCR array and reverse transcriptase PCR analysis, respectively. Interestingly, addition of the myosin light chain kinase inhibitor, ML-7, enhances the fragmentation, whereas phosphatase inhibitor perturbs the 3MC induced fragmentation of myotubes. These results suggest that decrease in RLC{sub 20} phosphorylation may be associated with the fragmentation step of dedifferentiation. - Highlights: • 3-Methylcholanthrene induces fragmentation of C2C12-myotubes. • Dedifferentiation can be divided into two steps – fragmentation and proliferation. • Fragmentation is associated with rearrangement of nonmuscle myosin II. • Genes associated with differentiation and proliferation are not altered during fragmentation. • Phosphorylation of myosin regulatory light chain is reduced during fragmentation.

  3. Dynamics of tropomyosin in muscle fibers as monitored by saturation transfer EPR of bi-functional probe.

    Directory of Open Access Journals (Sweden)

    Roni F Rayes

    Full Text Available The dynamics of four regions of tropomyosin was assessed using saturation transfer electron paramagnetic resonance in the muscle fiber. In order to fully immobilize the spin probe on the surface of tropomyosin, a bi-functional spin label was attached to i,i+4 positions via cysteine mutagenesis. The dynamics of bi-functionally labeled tropomyosin mutants decreased by three orders of magnitude when reconstituted into "ghost muscle fibers". The rates of motion varied along the length of tropomyosin with the C-terminus position 268/272 being one order of magnitude slower then N-terminal domain or the center of the molecule. Introduction of troponin decreases the dynamics of all four sites in the muscle fiber, but there was no significant effect upon addition of calcium or myosin subfragment-1.

  4. Tropomyosin Promotes Lamellipodial Persistence by Collaborating with Arp2/3 at the Leading Edge.

    Science.gov (United States)

    Brayford, Simon; Bryce, Nicole S; Schevzov, Galina; Haynes, Elizabeth M; Bear, James E; Hardeman, Edna C; Gunning, Peter W

    2016-05-23

    At the leading edge of migrating cells, protrusion of the lamellipodium is driven by Arp2/3-mediated polymerization of actin filaments [1]. This dense, branched actin network is promoted and stabilized by cortactin [2, 3]. In order to drive filament turnover, Arp2/3 networks are remodeled by proteins such as GMF, which blocks the actin-Arp2/3 interaction [4, 5], and coronin 1B, which acts by directing SSH1L to the lamellipodium where it activates the actin-severing protein cofilin [6, 7]. It has been shown in vitro that cofilin-mediated severing of Arp2/3 actin networks results in the generation of new pointed ends to which the actin-stabilizing protein tropomyosin (Tpm) can bind [8]. The presence of Tpm in lamellipodia, however, is disputed in the literature [9-19]. Here, we report that the Tpm isoforms 1.8/9 are enriched in the lamellipodium of fibroblasts as detected with a novel isoform-specific monoclonal antibody. RNAi-mediated silencing of Tpm1.8/9 led to an increase of Arp2/3 accumulation at the cell periphery and a decrease in the persistence of lamellipodia and cell motility, a phenotype consistent with cortactin- and coronin 1B-deficient cells [2, 7]. In the absence of coronin 1B or cofilin, Tpm1.8/9 protein levels are reduced while, conversely, inhibition of Arp2/3 with CK666 leads to an increase in Tpm1.8/9 protein. These findings establish a novel regulatory mechanism within the lamellipodium whereby Tpm collaborates with Arp2/3 to promote lamellipodial-based cell migration. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Phosphorylation of Tropomyosin Extends Cooperative Binding of Myosin Beyond a Single Regulatory Unit

    OpenAIRE

    Rao, Vijay S.; Marongelli, Ellisha N.; Guilford, William H.

    2009-01-01

    Tropomyosin (Tm) is one of the major phosphoproteins comprising the thin filament of muscle. However, the specific role of Tm phosphorylation in modulating the mechanics of actomyosin interaction has not been determined. Here we show that Tm phosphorylation is necessary for long-range cooperative activation of myosin binding. We used a novel optical trapping assay to measure the isometric stall force of an ensemble of myosin molecules moving actin filaments reconstituted with either natively ...

  6. Expression of a novel cardiac-specific tropomyosin isoform in humans

    International Nuclear Information System (INIS)

    Denz, Christopher R.; Narshi, Aruna; Zajdel, Robert W.; Dube, Dipak K.

    2004-01-01

    Tropomyosins are a family of actin binding proteins encoded by a group of highly conserved genes. Humans have four tropomyosin-encoding genes: TPM1, TPM2, TPM3, and TPM4, each of which is known to generate multiple isoforms by alternative splicing, promoters, and 3 ' end processing. TPM1 is the most versatile and encodes a variety of tissue specific isoforms. The TPM1 isoform specific to striated muscle, designated TPM1α, consists of 10 exons: 1a, 2b, 3, 4, 5, 6b, 7, 8, and 9a/b. In this study, using RT-PCR with adult and fetal human RNAs, we present evidence for the expression of a novel isoform of the TPM1 gene that is specifically expressed in cardiac tissues. The new isoform is designated TPM1κ and contains exon 2a instead of 2b. Ectopic expression of human GFP.TPM1κ fusion protein can promote myofibrillogenesis in cardiac mutant axolotl hearts that are lacking in tropomyosin

  7. Influence of Thermal Treatment on the Characteristics of Major Oyster Allergen Cra g 1 (Tropomyosin).

    Science.gov (United States)

    Fang, Lei; Li, Guoming; Gu, Ruizeng; Cai, Muyi; Lu, Jun

    2018-04-15

    Shellfish, including oysters, often cause allergic reactions in adults. Thermal treatment is one of the most common technologies to deal with seafood, which may affect biological properties. The aim of this work was to evaluate the impact of heating on conformation and potential allergenicity of oyster-derived tropomyosin (Cra g 1). SDS-PAGE showed that there was an apparent band at 35KD of raw tropomyosin after purification and more significant polymers appeared in heated protein. Interestingly, the obviously changes in the intensity of CD signal and ANS-binding fluorescence were observed especially in the case of roasted form, which was associated with an increase in antibody reactivity. The degree of IgE binding of this treatment was demonstrated in the order roasted>boiled > raw. Furthermore, sequence alignment and amino acid composition revealed that Cra g 1 shared relatively high homology to tropomyosins from other shellfish and was abundant in lysine that was apt to be modified by reducing sugars during heating. Heated Cra g 1 produces higher IgE reactivity than raw one, owing to denaturation and formation of polymers. These findings will benefit more diagnosis and management of potential allergenicity due to shellfish. This article is protected by copyright. All rights reserved.

  8. Tropomyosin and Actin Identified as Major Allergens of the Carpet Clam (Paphia textile and the Effect of Cooking on Their Allergenicity

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    Zailatul Hani Mohamad Yadzir

    2015-01-01

    Full Text Available Objectives. To identify the major allergenic proteins of clam (Paphia textile and to investigate the effect of different cooking methods on the allergenicity of these identified proteins. Methods. Clam protein extracts were separated by denaturing polyacrylamide gel electrophoresis. IgE reactive proteins were then analyzed by immunoblotting with sera from patients with positive skin prick tests (SPT to the raw clam extract. Mass spectrometry was used to identify the major allergenic proteins of this clam. Results. Raw extract showed 12 protein bands (18–150 kDa. In contrast, fewer protein bands were seen in the boiled extract; those ranging from 40 to 150 kDa were denatured. The protein profiles were similarly altered by frying or roasting. The immunoblots of raw and boiled extracts yielded 10 and 2 IgE-binding proteins, respectively. The fried and roasted extracts showed only a single IgE-binding protein at 37 kDa. Mass spectrometry analysis of the 37 and 42 kDa major allergens indicated that these spots were tropomyosin and actin, respectively. Conclusion. The two major allergens of Paphia textile were identified as the thermostable tropomyosin and a new thermolabile allergen actin.

  9. Autoimmunity to Tropomyosin-Specific Peptides Induced by Mycobacterium leprae in Leprosy Patients: Identification of Mimicking Proteins

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    Itu Singh

    2018-04-01

    Full Text Available BackgroundIt has been shown earlier that there is a rise in the levels of autoantibodies and T cell response to cytoskeletal proteins in leprosy. Our group recently demonstrated a rise in both T and B cell responses to keratin and myelin basic protein in all types of leprosy patients and their associations in type 1 reaction (T1R group of leprosy.ObjectivesIn this study, we investigated the association of levels of autoantibodies and lymphoproliferation against myosin in leprosy patients across the spectrum and tried to find out the mimicking proteins or epitopes between host protein and protein/s of Mycobacterium leprae.MethodologyOne hundred and sixty-nine leprosy patients and 55 healthy controls (HC were enrolled in the present study. Levels of anti-myosin antibodies and T-cell responses against myosin were measured by ELISA and lymphoproliferation assay, respectively. Using 2-D gel electrophoresis, western blot and MALDI-TOF/TOF antibody-reactive spots were identified. Three-dimensional structure of mimicking proteins was modeled by online server. B cell epitopes of the proteins were predicted by BCPREDS server 1.0 followed by identification of mimicking epitopes. Mice of inbred BALB/c strain were hyperimmunized with M. leprae soluble antigen (MLSA and splenocytes and lymph node cells of these animals were adoptively transferred to naïve mice.ResultsHighest level of anti-myosin antibodies was noted in sera of T1R leprosy patients. We observed significantly higher levels of lymphoproliferative response (p < 0.05 with myosin in all types of leprosy patients compared to HC. Further, hyperimmunization of inbred BALB/c strain of female mice and rabbit with MLSA revealed that both hyperimmunized rabbit and mice evoked heightened levels of antibodies against myosin and this autoimmune response could be adoptively transferred from hyperimmunized to naïve mice. Tropomyosin was found to be mimicking with ATP-dependent Clp protease ATP

  10. Novel Multisensor Probe for Monitoring Bladder Temperature During Locoregional Chemohyperthermia for Nonmuscle-Invasive Bladder Cancer: Technical Feasibility Study

    Science.gov (United States)

    Geijsen, Debby E.; Zum Vörde Sive Vörding, Paul J.; Schooneveldt, Gerben; Sijbrands, Jan; Hulshof, Maarten C.; de la Rosette, Jean; de Reijke, Theo M.; Crezee, Hans

    2013-01-01

    Abstract Background and Purpose: The effectiveness of locoregional hyperthermia combined with intravesical instillation of mitomycin C to reduce the risk of recurrence and progression of intermediate- and high-risk nonmuscle-invasive bladder cancer is currently investigated in clinical trials. Clinically effective locoregional hyperthermia delivery necessitates adequate thermal dosimetry; thus, optimal thermometry methods are needed to monitor accurately the temperature distribution throughout the bladder wall. The aim of the study was to evaluate the technical feasibility of a novel intravesical device (multi-sensor probe) developed to monitor the local bladder wall temperatures during loco-regional C-HT. Materials and Methods: A multisensor thermocouple probe was designed for deployment in the human bladder, using special sensors to cover the bladder wall in different directions. The deployment of the thermocouples against the bladder wall was evaluated with visual, endoscopic, and CT imaging in bladder phantoms, porcine models, and human bladders obtained from obduction for bladder volumes and different deployment sizes of the probe. Finally, porcine bladders were embedded in a phantom and subjected to locoregional heating to compare probe temperatures with additional thermometry inside and outside the bladder wall. Results: The 7.5 cm thermocouple probe yielded optimal bladder wall contact, adapting to different bladder volumes. Temperature monitoring was shown to be accurate and representative for the actual bladder wall temperature. Conclusions: Use of this novel multisensor probe could yield a more accurate monitoring of the bladder wall temperature during locoregional chemohyperthermia. PMID:24112045

  11. Nonmuscle myosin IIA and IIB differentially contribute to intrinsic and directed migration of human embryonic lung fibroblasts.

    Science.gov (United States)

    Kuragano, Masahiro; Murakami, Yota; Takahashi, Masayuki

    2018-03-25

    Nonmuscle myosin II (NMII) plays an essential role in directional cell migration. In this study, we investigated the roles of NMII isoforms (NMIIA and NMIIB) in the migration of human embryonic lung fibroblasts, which exhibit directionally persistent migration in an intrinsic manner. NMIIA-knockdown (KD) cells migrated unsteadily, but their direction of migration was approximately maintained. By contrast, NMIIB-KD cells occasionally reversed their direction of migration. Lamellipodium-like protrusions formed in the posterior region of NMIIB-KD cells prior to reversal of the migration direction. Moreover, NMIIB KD led to elongation of the posterior region in migrating cells, probably due to the lack of load-bearing stress fibers in this area. These results suggest that NMIIA plays a role in steering migration by maintaining stable protrusions in the anterior region, whereas NMIIB plays a role in maintenance of front-rear polarity by preventing aberrant protrusion formation in the posterior region. These distinct functions of NMIIA and NMIIB might promote intrinsic and directed migration of normal human fibroblasts. Copyright © 2018 Elsevier Inc. All rights reserved.

  12. Nonmuscle Myosin II Is Required for Internalization of the Epidermal Growth Factor Receptor and Modulation of Downstream Signaling*

    Science.gov (United States)

    Kim, Jong Hyun; Wang, Aibing; Conti, Mary Anne; Adelstein, Robert S.

    2012-01-01

    Ligand-induced internalization of the epidermal growth factor receptor (EGFR) is an important process for regulating signal transduction, cellular dynamics, and cell-cell communication. Here, we demonstrate that nonmuscle myosin II (NM II) is required for the internalization of the EGFR and to trigger the EGFR-dependent activation of ERK and AKT. The EGFR was identified as a protein that interacts with NM II by co-immunoprecipitation and mass spectrometry analysis. This interaction requires both the regulatory light chain 20 (RLC20) of NM II and the kinase domain of the EGFR. Two paralogs of NM II, NM II-A, and NM II-B can act to internalize the EGFR, depending on the cell type and paralog content of the cell line. Loss (siRNA) or inhibition (25 μm blebbistatin) of NM II attenuates the internalization of the EGFR and impairs EGFR-dependent activation of ERK and AKT. Both internalization of the EGFR and downstream signaling to ERK and AKT can be partially restored in siRNA-treated cells by introduction of wild type (WT) GFP-NM II, but cannot be restored by motor mutant NM II. Taken together, these results suggest that NM II plays a role in the internalization of the EGFR and EGFR-mediated signaling pathways. PMID:22718763

  13. The interaction between tropomyosin-related kinase B receptors and serine kinases modulates acetylcholine release in adult neuromuscular junctions.

    Science.gov (United States)

    Santafé, Manel M; Garcia, Neus; Tomàs, Marta; Obis, Teresa; Lanuza, Maria A; Besalduch, Nuria; Tomàs, Josep

    2014-02-21

    We conducted an electrophysiological study of the functional link between the tropomyosin-related kinase B (trkB) receptor signaling mechanism and serine-threonine kinases, both protein kinase C (PKC) and protein kinase A (PKA). We describe their coordinated role in transmitter release at the neuromuscular junction (NMJ) of the Levator auris longus muscle of the adult mouse. The trkB receptor normally seems to be coupled to stimulate ACh release because inhibiting the trkB receptor with K-252a results in a significant reduction in the size of EPPs. We found that the intracellular PKC pathway can operate as in basal conditions (to potentiate ACh release) without the involvement of the trkB receptor function, although the trkB pathway needs an operative PKC pathway if it is to couple to the release mechanism and potentiate it. To actively stimulate PKA (which also results in ACh release potentiation), the operativity of trkB is a necessary condition, and one effect of trkB may be PKA stimulation. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  14. Determining the effect of malondialdehyde on the IgE-binding capacity of shrimp tropomyosin upon in vitro digestion.

    Science.gov (United States)

    Lv, Liangtao; Lin, Hong; Li, Zhenxing; Ahmed, Ishfaq; Chen, Guanzhi

    2017-10-01

    Stability in simulated gastric fluids is considered an important parameter for the estimation of food allergenicity. Moreover, proteins in food are highly susceptible to lipid oxidation during processing and preservation. In this study, the change in the IgE-binding capacity of malondialdehyde (MDA)-treated shrimp tropomyosin (TM) following in vitro digestion was investigated by SDS-PAGE and western blot. Shrimp TM treated with different concentrations of MDA was slightly degraded and became increasingly resistant to pepsin digestion over time. While untreated TM was rapidly degraded, MDA-treated TM showed some resistance and was degraded by trypsin only after increasing the digestion time. Results of immunoblotting studies on IgE using sera from patients allergic to shrimp indicated that the IgE-binding capacity of TM and MDA (50 mmol L -1 )-treated TM decreased slightly after pepsin digestion and significantly decreased after trypsin digestion. The study indicated that the resistance of TM to degradation increased after oxidation. The treatment with proteases, especially trypsin, is quite effective in decreasing the IgG/IgE-binding capacity of shrimp TM. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  15. Cytoskeletal Tropomyosin Tm5NM1 Is Required for Normal Excitation–Contraction Coupling in Skeletal Muscle

    Science.gov (United States)

    Vlahovich, Nicole; Kee, Anthony J.; Van der Poel, Chris; Kettle, Emma; Hernandez-Deviez, Delia; Lucas, Christine; Lynch, Gordon S.; Parton, Robert G.; Gunning, Peter W.

    2009-01-01

    The functional diversity of the actin microfilaments relies in part on the actin binding protein tropomyosin (Tm). The muscle-specific Tms regulate actin-myosin interactions and hence contraction. However, there is less known about the roles of the numerous cytoskeletal isoforms. We have shown previously that a cytoskeletal Tm, Tm5NM1, defines a Z-line adjacent cytoskeleton in skeletal muscle. Recently, we identified a second cytoskeletal Tm in this region, Tm4. Here we show that Tm4 and Tm5NM1 define separate actin filaments; the former associated with the terminal sarcoplasmic reticulum (SR) and other tubulovesicular structures. In skeletal muscles of Tm5NM1 knockout (KO) mice, Tm4 localization was unchanged, demonstrating the specificity of the membrane association. Tm5NM1 KO muscles exhibit potentiation of T-system depolarization and decreased force rundown with repeated T-tubule depolarizations consistent with altered T-tubule function. These results indicate that a Tm5NM1-defined actin cytoskeleton is required for the normal excitation–contraction coupling in skeletal muscle. PMID:19005216

  16. Cytoskeletal tropomyosin Tm5NM1 is required for normal excitation-contraction coupling in skeletal muscle.

    Science.gov (United States)

    Vlahovich, Nicole; Kee, Anthony J; Van der Poel, Chris; Kettle, Emma; Hernandez-Deviez, Delia; Lucas, Christine; Lynch, Gordon S; Parton, Robert G; Gunning, Peter W; Hardeman, Edna C

    2009-01-01

    The functional diversity of the actin microfilaments relies in part on the actin binding protein tropomyosin (Tm). The muscle-specific Tms regulate actin-myosin interactions and hence contraction. However, there is less known about the roles of the numerous cytoskeletal isoforms. We have shown previously that a cytoskeletal Tm, Tm5NM1, defines a Z-line adjacent cytoskeleton in skeletal muscle. Recently, we identified a second cytoskeletal Tm in this region, Tm4. Here we show that Tm4 and Tm5NM1 define separate actin filaments; the former associated with the terminal sarcoplasmic reticulum (SR) and other tubulovesicular structures. In skeletal muscles of Tm5NM1 knockout (KO) mice, Tm4 localization was unchanged, demonstrating the specificity of the membrane association. Tm5NM1 KO muscles exhibit potentiation of T-system depolarization and decreased force rundown with repeated T-tubule depolarizations consistent with altered T-tubule function. These results indicate that a Tm5NM1-defined actin cytoskeleton is required for the normal excitation-contraction coupling in skeletal muscle.

  17. Urinary long noncoding RNAs in nonmuscle-invasive bladder cancer: new architects in cancer prognostic biomarkers.

    Science.gov (United States)

    Terracciano, Daniela; Ferro, Matteo; Terreri, Sara; Lucarelli, Giuseppe; D'Elia, Carolina; Musi, Gennaro; de Cobelli, Ottavio; Mirone, Vincenzo; Cimmino, Amelia

    2017-06-01

    Several reports over the last 10 years provided evidence that long noncoding RNAs (lncRNAs) are often altered in bladder cancers. lncRNAs are longer than 200 nucleotides and function as important regulators of gene expression, interacting with the major pathways of cell growth, proliferation, differentiation, and survival. A large number of lncRNAs has oncogenic function and is more expressed in tumor compared with normal tissues. Their overexpression may be associated with tumor formation, progression, and metastasis in a variety of tumors including bladder cancer. Although lncRNAs have been shown to have critical regulatory roles in cancer biology, the biological functions and prognostic values in nonmuscle-invasive bladder cancer remain largely unknown. Nevertheless, a growing body of evidence suggests that several lncRNAs expression profiles in bladder malignancies are associated with poor prognosis, and they can be detected in biological fluids, such as urines. Here, we review current progress in the biology and the implication of lncRNAs associated with bladder cancer, and we discuss their potential use as diagnosis and prognosis biomarkers in bladder malignancies with a focus on their role in high-risk nonmuscle-invasive tumors. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Carboxyl-terminal-dependent recruitment of nonmuscle myosin II to megakaryocyte contractile ring during polyploidization.

    Science.gov (United States)

    Badirou, Idinath; Pan, Jiajia; Legrand, Céline; Wang, Aibing; Lordier, Larissa; Boukour, Siham; Roy, Anita; Vainchenker, William; Chang, Yunhua

    2014-10-16

    Endomitosis is a unique megakaryocyte (MK) differentiation process that is the consequence of a late cytokinesis failure associated with a contractile ring defect. Evidence from in vitro studies has revealed the distinct roles of 2 nonmuscle myosin IIs (NMIIs) on MK endomitosis: only NMII-B (MYH10), but not NMII-A (MYH9), is localized in the MK contractile ring and implicated in mitosis/endomitosis transition. Here, we studied 2 transgenic mouse models in which nonmuscle myosin heavy chain (NMHC) II-A was genetically replaced either by II-B or by a chimeric NMHCII that combined the head domain of II-A with the rod and tail domains of II-B. This study provides in vivo evidence on the specific role of NMII-B on MK polyploidization. It demonstrates that the carboxyl-terminal domain of the heavy chains determines myosin II localization to the MK contractile ring and is responsible for the specific role of NMII-B in MK polyploidization.

  19. A panel of prognostic protein markers for progression in non-muscle invasive bladder cancer - a multicenter tissue microarray validation study

    DEFF Research Database (Denmark)

    Fristrup, Niels; Birkenkamp-Demtröder, Karin; Ulhøi, Benedicte Parm

    2012-01-01

    cohort of 283 patients with long-term follow-up. For validation of the results we used three independent patient cohorts with long-term follow-up from Sweden, Spain, and Taiwan. In total 649 primary NMIBC tissue-microarray specimens from patients with long-term follow-up were used. Protein expression......Bladder cancer is the fifth most common cancer in the Western world. The histopathological parameters used in the clinic cannot precisely predict the individual disease course. Bladder cancer patients are therefore monitored thoroughly for disease recurrence and progression by urine and cystoscopy...... Ta and T1 urothelial carcinomas. Transcripts from the five genes encoding these proteins were previously included in gene expression signatures for outcome prediction for non-muscle invasive bladder cancer (NMIBC). As a training-set, we used primary NMIBC tissue-microarray specimens from a Danish...

  20. Molecular Landscape of Non-Muscle Invasive Bladder Cancer.

    Science.gov (United States)

    Meeks, Joshua J; Lerner, Seth P

    2017-11-13

    In this issue of Cancer Cell, Hurst et al. report an integrated analysis of non-invasive (stage Ta) bladder cancer. Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling. Tumors from female patients have a higher frequency of KDM6A mutations. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Chromosomal imbalance in the progression of high-risk non-muscle invasive bladder cancer

    International Nuclear Information System (INIS)

    Zieger, Karsten; Wiuf, Carsten; Jensen, Klaus Møller-Ernst; Ørntoft, Torben Falck; Dyrskjøt, Lars

    2009-01-01

    Non-muscle invasive bladder neoplasms with invasion of the lamina propria (stage T1) or high grade of dysplasia are at 'high risk' of progression to life-threatening cancer. However, the individual course is difficult to predict. Chromosomal instability (CI) is associated with high tumor stage and grade, and possibly with the risk of progression. To investigate the relationship between CI and subsequent disease progression, we performed a case-control-study of 125 patients with 'high-risk' non-muscle invasive bladder neoplasms, 67 with later disease progression, and 58 with no progression. Selection criteria were conservative (non-radical) resections and full prospective clinical follow-up (> 5 years). We investigated primary lesions in 59, and recurrent lesions in 66 cases. We used Affymetrix GeneChip ® Mapping 10 K and 50 K SNP microarrays to evaluate genome wide chromosomal imbalance (loss-of-heterozygosity and DNA copy number changes) in 48 representative tumors. DNA copy number changes of 15 key instability regions were further investigated using QPCR in 101 tumors (including 25 tumors also analysed on 50 K SNP microarrays). Chromosomal instability did not predict any higher risk of subsequent progression. Stage T1 and high-grade tumors had generally more unstable genomes than tumors of lower stage and grade (mostly non-primary tumors following a 'high-risk' tumor). However, about 25% of the 'high-risk' tumors had very few alterations. This was independent of subsequent progression. Recurrent lesions represent underlying field disease. A separate analysis of these lesions did neither reflect any difference in the risk of progression. Of specific chromosomal alterations, a possible association between loss of chromosome 8p11 and the risk of progression was found. However, the predictive value was limited by the heterogeneity of the changes. Chromosomal instability (CI) was associated with 'high risk' tumors

  2. Am80 induces neuronal differentiation via increased tropomyosin-related kinase B expression in a human neuroblastoma SH-SY5Y cell line.

    Science.gov (United States)

    Shiohira, Hideo; Kitaoka, Akira; Enjoji, Munechika; Uno, Tsukasa; Nakashima, Manabu

    2012-01-01

    Am80, a synthetic retinoid, has been used in differentiation therapy for acute promyelocytic leukemia (APL). All-trans retinoic acid (ATRA) as one of natural retinoid has been also used to treat APL. ATRA treatment causes neuronal differentiation by inducing tropomyosin-related kinase B (TrkB) expression and increasing the sensitivity to brain-derived neurotrophic factor (BDNF), a TrkB ligand. In the present study, we investigated the effects of Am80 on neuronal differentiation, BDNF sensitivity and TrkB expression in human neuroblastoma SH-SY5Y cells. Treatment with Am80 induced morphological differentiation of neurite outgrowth and increased the expression of GAP43 mRNA, a neuronal differentiation marker. Additionally, TrkB protein was also increased, and exogenous BDNF stimulation after treatment with Am80 induced greater neurite outgrowth than without BDNF treatment. These results suggest that Am80 induced neuronal differentiation by increasing TrkB expression and BDNF sensitivity.

  3. Fluorescence cystoscopy in patients with non-muscle invasive bladder cancer

    Directory of Open Access Journals (Sweden)

    I. G. Rusakov

    2015-01-01

    Full Text Available The main challenge of treating non-muscle invasive bladder cancer is multifocal tumors. Current methods of diagnosis are failed to detect all superficial flat tumor lesions in bladder mucosa. The use of fluorescence imaging with 5-aminolevulinic acid (5-ALA allows to improve the sensibility of routine cystoscopy, but low specificity decreases its diagnostic accuracy. The method of fluorescence imaging combined with local fluorescence spectroscopy developed in P.A. Herzen MCRI has been shown to increase the specificity from 71% to 84%. Thus, local fluorescence spectroscopy in visible fluorescence of 5-ALA-induced protoporphyrin allows to perform guided biopsy and decrease the rate of diagnostic mistakes. 

  4. Optimal Treatment for Intermediate- and High-Risk, Nonmuscle-Invasive Bladder Cancer

    Directory of Open Access Journals (Sweden)

    A.P.M. van der Meijden

    2006-01-01

    Full Text Available According to clinical and pathological factors the prognosis of a patient with non-muscle invasive bladder tumors can be assessed. The prognosis is determined by the likelihood of recurrence(30-70% and/or progression to muscle invasive bladder cancer(1-15%.Trans urethral resection of bladder tumors remains the initial therapy but adjuvant intravesical instillations are necessary.All patients benefit from a single immediate post operative instillation with a chemotherapeutic agent and for low risk tumors this is the optimal therapy.Patients with intermediate and high risk tumors need more intravesical chemo-or immunotherapy. Chemotherapy reduces recurrences but not progression. Intravesical immunotherapy(BCG prevents or delays progression. Patients at high risk for progression may need upfront cystectomy.

  5. Functions of nonmuscle myosin II in assembly of the cellular contractile system.

    Directory of Open Access Journals (Sweden)

    Maria Shutova

    Full Text Available The contractile system of nonmuscle cells consists of interconnected actomyosin networks and bundles anchored to focal adhesions. The initiation of the contractile system assembly is poorly understood structurally and mechanistically, whereas system's maturation heavily depends on nonmuscle myosin II (NMII. Using platinum replica electron microscopy in combination with fluorescence microscopy, we characterized the structural mechanisms of the contractile system assembly and roles of NMII at early stages of this process. We show that inhibition of NMII by a specific inhibitor, blebbistatin, in addition to known effects, such as disassembly of stress fibers and mature focal adhesions, also causes transformation of lamellipodia into unattached ruffles, loss of immature focal complexes, loss of cytoskeleton-associated NMII filaments and peripheral accumulation of activated, but unpolymerized NMII. After blebbistatin washout, assembly of the contractile system begins with quick and coordinated recovery of lamellipodia and focal complexes that occurs before reappearance of NMII bipolar filaments. The initial formation of focal complexes and subsequent assembly of NMII filaments preferentially occurred in association with filopodial bundles and concave actin bundles formed by filopodial roots at the lamellipodial base. Over time, accumulating NMII filaments help to transform the precursor structures, focal complexes and associated thin bundles, into stress fibers and mature focal adhesions. However, semi-sarcomeric organization of stress fibers develops at much slower rate. Together, our data suggest that activation of NMII motor activity by light chain phosphorylation occurs at the cell edge and is uncoupled from NMII assembly into bipolar filaments. We propose that activated, but unpolymerized NMII initiates focal complexes, thus providing traction for lamellipodial protrusion. Subsequently, the mechanical resistance of focal complexes activates a

  6. Life without double-headed non-muscle myosin II motor proteins

    Science.gov (United States)

    Betapudi, Venkaiah

    2014-07-01

    Non-muscle myosin II motor proteins (myosin IIA, myosin IIB, and myosin IIC) belong to a class of molecular motor proteins that are known to transduce cellular free-energy into biological work more efficiently than man-made combustion engines. Nature has given a single myosin II motor protein for lower eukaryotes and multiple for mammals but none for plants in order to provide impetus for their life. These specialized nanomachines drive cellular activities necessary for embryogenesis, organogenesis, and immunity. However, these multifunctional myosin II motor proteins are believed to go awry due to unknown reasons and contribute for the onset and progression of many autosomal-dominant disorders, cataract, deafness, infertility, cancer, kidney, neuronal, and inflammatory diseases. Many pathogens like HIV, Dengue, hepatitis C, and Lymphoma viruses as well as Salmonella and Mycobacteria are now known to take hostage of these dedicated myosin II motor proteins for their efficient pathogenesis. Even after four decades since their discovery, we still have a limited knowledge of how these motor proteins drive cell migration and cytokinesis. We need to enrich our current knowledge on these fundamental cellular processes and develop novel therapeutic strategies to fix mutated myosin II motor proteins in pathological conditions. This is the time to think how to relieve the hijacked myosins from pathogens in order to provide a renewed impetus for patients’ life. Understanding how to steer these molecular motors in proliferating and differentiating stem cells will improve stem cell based-therapeutics development. Given the plethora of cellular activities non-muscle myosin motor proteins are involved in, their importance is apparent for human life.

  7. Quality-of-life survey for patients diagnosed with nonmuscle-invasive bladder cancer.

    Science.gov (United States)

    Abáigar-Pedraza, I; Megías-Garrigós, J; Sánchez-Payá, J

    2016-05-01

    To determine the reliability and validity of a quality-of-life survey for patients with nonmuscle-invasive bladder cancer. A total of 180 patients were included in the study. We developed a survey with 21 questions grouped into 5 areas. The patients filled in this survey and the Functional Assessment of Cancer Therapy - Bladder Cancer (FACT-BL) survey. To assess reliability, we calculated Cronbach's alpha coefficient and the kappa index. To determine criterion validity, we studied the association between the scores obtained from our survey and those from the FACT-BL survey using the Pearson correlation coefficient. To determine the construct validity (factorial and discriminatory), we performed a factor analysis, comparing it with Student's t-test for the scores obtained according to the tumour characteristics of reduced quality of life (e.g., malignancies located at the trigone of the bladder). Cronbach's alpha reliability coefficient was .83, and the kappa index varied between .7 and 1. For the association study between the new survey and the FACT-BL survey, we measured an r=.82 for the overall score and between r=.68 (disease) and r=.97 (sex life) in the various measures. In the factor analysis, we measured a Kaiser-Meyer-Olkin index of .77 and performed the Barlett test (P<.001). The comparison between the scores, in the presence or absence of certain tumour characteristics, has shown a reduced quality of life when those characteristics are present, which was statistically significant (P<.05) in the majority of cases. Our survey to measure the quality of life of patients with nonmuscle-invasive bladder cancer is reliable and valid. Copyright © 2015 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

  8. Life without double-headed non-muscle myosin II motor proteins

    Directory of Open Access Journals (Sweden)

    Venkaiah eBetapudi

    2014-07-01

    Full Text Available Non-muscle myosin II motor proteins (myosin IIA, myosin IIB, and myosin IIC belong to a class of molecular motor proteins that are known to transduce cellular free-energy into biological work more efficiently than man-made combustion engines. Nature has given a single myosin II motor protein for lower eukaryotes and multiple for mammals but none for plants in order to provide impetus for their life. These specialized nanomachines drive cellular activities necessary for embryogenesis, organogenesis, and immunity. However, these multifunctional myosin II motor proteins are believed to go awry due to unknown reasons and contribute for the onset and progression of many autosomal-dominant disorders, cataract, deafness, infertility, cancer, kidney, neuronal, and inflammatory diseases. Many pathogens like HIV, Dengue, hepatitis C, and Lymphoma viruses as well as Salmonella and Mycobacteria are now known to take hostage of these dedicated myosin II motor proteins for their efficient pathogenesis. Even after four decades since their discovery, we still have a limited knowledge of how these motor proteins drive cell migration and cytokinesis. We need to enrich our current knowledge on these fundamental cellular processes and develop novel therapeutic strategies to fix mutated myosin II motor proteins in pathological conditions. This is the time to think how to relieve the hijacked myosins from pathogens in order to provide a renewed impetus for patients’ life. Understanding how to steer these molecular motors in proliferating and differentiating stem cells will improve stem cell based-therapeutics development. Given the plethora of cellular activities non-muscle myosin motor proteins are involved in, their importance is apparent for human life.

  9. Non-Muscle Myosin II Isoforms Have Different Functions in Matrix Rearrangement by MDA-MB-231 Cells.

    Directory of Open Access Journals (Sweden)

    Bridget Hindman

    Full Text Available The role of a stiffening extra-cellular matrix (ECM in cancer progression is documented but poorly understood. Here we use a conditioning protocol to test the role of nonmuscle myosin II isoforms in cell mediated ECM arrangement using collagen constructs seeded with breast cancer cells expressing shRNA targeted to either the IIA or IIB heavy chain isoform. While there are several methods available to measure changes in the biophysical characteristics of the ECM, we wanted to use a method which allows for the measurement of global stiffness changes as well as a dynamic response from the sample over time. The conditioning protocol used allows the direct measurement of ECM stiffness. Using various treatments, it is possible to determine the contribution of various construct and cellular components to the overall construct stiffness. Using this assay, we show that both the IIA and IIB isoforms are necessary for efficient matrix remodeling by MDA-MB-231 breast cancer cells, as loss of either isoform changes the stiffness of the collagen constructs as measured using our conditioning protocol. Constructs containing only collagen had an elastic modulus of 0.40 Pascals (Pa, parental MDA-MB-231 constructs had an elastic modulus of 9.22 Pa, while IIA and IIB KD constructs had moduli of 3.42 and 7.20 Pa, respectively. We also calculated the cell and matrix contributions to the overall sample elastic modulus. Loss of either myosin isoform resulted in decreased cell stiffness, as well as a decrease in the stiffness of the cell-altered collagen matrices. While the total construct modulus for the IIB KD cells was lower than that of the parental cells, the IIB KD cell-altered matrices actually had a higher elastic modulus than the parental cell-altered matrices (4.73 versus 4.38 Pa. These results indicate that the IIA and IIB heavy chains play distinct and non-redundant roles in matrix remodeling.

  10. Tus-Ter-lock immuno-PCR assays for the sensitive detection of tropomyosin-specific IgE antibodies.

    Science.gov (United States)

    Johnston, Elecia B; Kamath, Sandip D; Lopata, Andreas L; Schaeffer, Patrick M

    2014-02-01

    The increasing prevalence of food allergies requires development of specific and sensitive tests capable of identifying the allergen responsible for the disease. The development of serologic tests that can detect specific IgE antibodies to allergenic proteins would, therefore, be highly received. Here we present two new quantitative immuno-PCR assays for the sensitive detection of antibodies specific to the shrimp allergen tropomyosin. Both assays are based on the self-assembling Tus-Ter-lock protein-DNA conjugation system. Significantly elevated levels of tropomyosin-specific IgE were detected in sera from patients allergic to shrimp. This is the first time an allergenic protein has been fused with Tus to enable specific IgE antibody detection in human sera by quantitative immuno-PCR.

  11. The N-terminal tropomyosin- and actin-binding sites are important for leiomodin 2's function.

    Science.gov (United States)

    Ly, Thu; Moroz, Natalia; Pappas, Christopher T; Novak, Stefanie M; Tolkatchev, Dmitri; Wooldridge, Dayton; Mayfield, Rachel M; Helms, Gregory; Gregorio, Carol C; Kostyukova, Alla S

    2016-08-15

    Leiomodin is a potent actin nucleator related to tropomodulin, a capping protein localized at the pointed end of the thin filaments. Mutations in leiomodin-3 are associated with lethal nemaline myopathy in humans, and leiomodin-2-knockout mice present with dilated cardiomyopathy. The arrangement of the N-terminal actin- and tropomyosin-binding sites in leiomodin is contradictory and functionally not well understood. Using one-dimensional nuclear magnetic resonance and the pointed-end actin polymerization assay, we find that leiomodin-2, a major cardiac isoform, has an N-terminal actin-binding site located within residues 43-90. Moreover, for the first time, we obtain evidence that there are additional interactions with actin within residues 124-201. Here we establish that leiomodin interacts with only one tropomyosin molecule, and this is the only site of interaction between leiomodin and tropomyosin. Introduction of mutations in both actin- and tropomyosin-binding sites of leiomodin affected its localization at the pointed ends of the thin filaments in cardiomyocytes. On the basis of our new findings, we propose a model in which leiomodin regulates actin poly-merization dynamics in myocytes by acting as a leaky cap at thin filament pointed ends. © 2016 Ly, Moroz, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  12. Non-muscle myosin II in disease: mechanisms and therapeutic opportunities

    Directory of Open Access Journals (Sweden)

    Karen A. Newell-Litwa

    2015-12-01

    Full Text Available The actin motor protein non-muscle myosin II (NMII acts as a master regulator of cell morphology, with a role in several essential cellular processes, including cell migration and post-synaptic dendritic spine plasticity in neurons. NMII also generates forces that alter biochemical signaling, by driving changes in interactions between actin-associated proteins that can ultimately regulate gene transcription. In addition to its roles in normal cellular physiology, NMII has recently emerged as a critical regulator of diverse, genetically complex diseases, including neuronal disorders, cancers and vascular disease. In the context of these disorders, NMII regulatory pathways can be directly mutated or indirectly altered by disease-causing mutations. NMII regulatory pathway genes are also increasingly found in disease-associated copy-number variants, particularly in neuronal disorders such as autism and schizophrenia. Furthermore, manipulation of NMII-mediated contractility regulates stem cell pluripotency and differentiation, thus highlighting the key role of NMII-based pharmaceuticals in the clinical success of stem cell therapies. In this Review, we discuss the emerging role of NMII activity and its regulation by kinases and microRNAs in the pathogenesis and prognosis of a diverse range of diseases, including neuronal disorders, cancer and vascular disease. We also address promising clinical applications and limitations of NMII-based inhibitors in the treatment of these diseases and the development of stem-cell-based therapies.

  13. RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization.

    Science.gov (United States)

    Lordier, Larissa; Bluteau, Dominique; Jalil, Abdelali; Legrand, Céline; Pan, Jiajia; Rameau, Philippe; Jouni, Dima; Bluteau, Olivier; Mercher, Thomas; Leon, Catherine; Gachet, Christian; Debili, Najet; Vainchenker, William; Raslova, Hana; Chang, Yunhua

    2012-03-06

    Megakaryocytes are unique mammalian cells that undergo polyploidization (endomitosis) during differentiation, leading to an increase in cell size and protein production that precedes platelet production. Recent evidence demonstrates that endomitosis is a consequence of a late failure in cytokinesis associated with a contractile ring defect. Here we show that the non-muscle myosin IIB heavy chain (MYH10) is expressed in immature megakaryocytes and specifically localizes in the contractile ring. MYH10 downmodulation by short hairpin RNA increases polyploidization by inhibiting the return of 4N cells to 2N, but other regulators, such as of the G1/S transition, might regulate further polyploidization of the 4N cells. Conversely, re-expression of MYH10 in the megakaryocytes prevents polyploidization and the transition of 2N to 4N cells. During polyploidization, MYH10 expression is repressed by the major megakaryocyte transcription factor RUNX1. Thus, RUNX1-mediated silencing of MYH10 is required for the switch from mitosis to endomitosis, linking polyploidization with megakaryocyte differentiation.

  14. Absolute quantification method and validation of airborne snow crab allergen tropomyosin using tandem mass spectrometry

    International Nuclear Information System (INIS)

    Rahman, Anas M. Abdel; Lopata, Andreas L.; Randell, Edward W.; Helleur, Robert J.

    2010-01-01

    Measuring the levels of the major airborne allergens of snow crab in the workplace is very important in studying the prevalence of crab asthma in workers. Previously, snow crab tropomyosin (SCTM) was identified as the major aeroallergen in crab plants and a unique signature peptide was identified for this protein. The present study advances our knowledge on aeroallergens by developing a method of quantification of airborne SCTM by using isotope dilution mass spectrometry. Liquid chromatography tandem mass spectrometry was developed for separation and analysis of the signature peptides. The tryptic digestion conditions were optimized to accomplish complete digestion. The validity of the method was studied using international conference on harmonization protocol, Where 2-9% for CV (precision) and 101-110% for accuracy, at three different levels of quality control. Recovery of the spiked protein from PTFE and TopTip filters was measured to be 99% and 96%, respectively. To further demonstrate the applicability and the validity of the method for real samples, 45 kg of whole snow crab were processed in an enclosed (simulated) crab processing line and air samples were collected. The levels of SCTM ranged between 0.36-3.92 μg m -3 and 1.70-2.31 μg m -3 for butchering and cooking stations, respectively.

  15. Absolute quantification method and validation of airborne snow crab allergen tropomyosin using tandem mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Rahman, Anas M. Abdel, E-mail: anasar@mun.ca [Department of Chemistry, Memorial University of Newfoundland, St. John' s, Newfoundland A1B 3X7 (Canada); Lopata, Andreas L. [School of Applied Science, Marine Biomedical Sciences and Health Research Group, RMIT University, Bundoora, 3083 Victoria (Australia); Randell, Edward W. [Department of Laboratory Medicine, Memorial University of Newfoundland, Eastern Health, St. John' s, Newfoundland and Labrador A1B 3V6 (Canada); Helleur, Robert J. [Department of Chemistry, Memorial University of Newfoundland, St. John' s, Newfoundland A1B 3X7 (Canada)

    2010-11-29

    Measuring the levels of the major airborne allergens of snow crab in the workplace is very important in studying the prevalence of crab asthma in workers. Previously, snow crab tropomyosin (SCTM) was identified as the major aeroallergen in crab plants and a unique signature peptide was identified for this protein. The present study advances our knowledge on aeroallergens by developing a method of quantification of airborne SCTM by using isotope dilution mass spectrometry. Liquid chromatography tandem mass spectrometry was developed for separation and analysis of the signature peptides. The tryptic digestion conditions were optimized to accomplish complete digestion. The validity of the method was studied using international conference on harmonization protocol, Where 2-9% for CV (precision) and 101-110% for accuracy, at three different levels of quality control. Recovery of the spiked protein from PTFE and TopTip filters was measured to be 99% and 96%, respectively. To further demonstrate the applicability and the validity of the method for real samples, 45 kg of whole snow crab were processed in an enclosed (simulated) crab processing line and air samples were collected. The levels of SCTM ranged between 0.36-3.92 {mu}g m{sup -3} and 1.70-2.31 {mu}g m{sup -3} for butchering and cooking stations, respectively.

  16. The Maillard Reaction Reduced the Sensitization of Tropomyosin and Arginine Kinase from Scylla paramamosain, Simultaneously.

    Science.gov (United States)

    Han, Xin-Yu; Yang, Huang; Rao, Shi-Tao; Liu, Guang-Yu; Hu, Meng-Jun; Zeng, Bin-Chang; Cao, Min-Jie; Liu, Guang-Ming

    2018-03-21

    The Maillard reaction was established to reduce the sensitization of tropomyosin (TM) and arginine kinase (AK) from Scylla paramamosain, and the mechanism of the attenuated sensitization was investigated. In the present study, the Maillard reaction conditions were optimized for heating at 100 °C for 60 min (pH 8.5) with arabinose. A low level of allergenicity in mice was shown by the levels of allergen-specific antibodies, and more Th1 and less Th2 cells cytokines produced and associated transcription factors with the Maillard reacted allergen (mAllergen). The tolerance potency in mice was demonstrated by the increased ratio of Th1/Th2 cytokines. Moreover, mass spectrometry analysis showed that some key amino acids of IgE-binding epitopes (K 112 , R 125 , R 133 of TM; K 33 , K 118 , R 202 of AK) were modified by the Maillard reaction. The Maillard reaction with arabinose reduced the sensitization of TM and AK, which may be due to the masked epitopes.

  17. Quality of life in patients with muscle invasive and non-muscle invasive bladder cancer.

    Science.gov (United States)

    Singer, S; Ziegler, C; Schwalenberg, T; Hinz, A; Götze, H; Schulte, T

    2013-05-01

    Compared to the literature on other malignancies, data on quality of life (QoL) in bladder cancer are sparse. This study sought answers to the following questions: In what QoL domains do patients with bladder cancer differ from the general population? Do patients with radical cystectomy differ in QoL compared to those who received conservative treatment? Do patients with neobladder generally have better QoL compared to patients with other diversion methods? At the beginning of inpatient rehabilitation, N = 823 patients with bladder cancer were assessed. Data of a representative community sample (N = 2037) were used for comparison. The questionnaire EORTC QLQ-C30 was used to measure QoL. Multivariate linear regression models were computed to investigate differences between groups. Patients with both non-muscle invasive and muscle invasive bladder cancer reported significantly more problems and worse functioning than the general population. Radiotherapy is associated with clinically relevant more pain, dyspnoea, constipation, appetite loss and decreased social functioning while chemotherapy is associated more with dyspnoea. Cystectomy patients reported more fatigue, appetite loss and decreased role functioning. Male patients ≥70 years with conduit experienced more sleep and emotional problems. These effects of urinary diversion were not observed in women and younger patients. Patients with bladder cancer experience various QoL concerns at the beginning of inpatient rehabilitation. These problems can partly be explained by the type of treatment the patients receive. Type of urinary diversion is relevant for QoL in subgroups of patients.

  18. Managing Patients with Non-Muscle Invasive Bladder Cancer: Old Disease, New Ideas

    Directory of Open Access Journals (Sweden)

    Per-Uno Malmström

    2016-04-01

    Full Text Available Prof Per-Uno Malmström opened this symposium on non-muscle invasive bladder cancer (NMIBC by describing the medical and economic burden caused by the increasing incidence of bladder cancer and the lack of new therapeutic options available to address the challenges of the management of NMIBC. Prof Marko Babjuk followed with a presentation that demonstrated that risk stratification using European Organisation for Research and Treatment of Cancer (EORTC and Spanish Urological Club for Oncological Treatment (CUETO risk scores remains a useful tool for determining the best individual treatment options for patients. The next presentation, given by Dr Carsten Ohlmann, described the use of mitomycin C (MMC for low and intermediate-risk patients as per the European Association of Urology (EAU guidelines. However, despite a favourable safety profile, single case reports of severe adverse events following treatment with MMC should not be dismissed. MMC should therefore be given with care, with an emphasis on performing high quality transurethral resection of the bladder (TURB. Prof Bernard Malavaud then presented details of newer diagnostic methods, such as photodynamic diagnosis (PDD and narrow band imaging (NBI, which offer better optical tumour recognition for the surgeon than the old standard of white light cystoscopy. The uptake of PDD and NBI in the future will facilitate an increase in the quality of TURB. Finally, Prof Ashish Kamat explained that recurrence of bladder cancer after bacillus Calmette–Guérin (BCG treatment (‘BCG failure’ needs to be more clearly defined and stratified. He stated that optimal recognition of timing with relation to BCG immunotherapy is critical to determine the next steps. For example, in the past, patients with late recurrence who may have benefitted from challenge with BCG may have been overlooked.

  19. Cardiac troponin and tropomyosin: structural and cellular perspectives to unveil the Hypertrophic Cardiomyopathy phenotype

    Directory of Open Access Journals (Sweden)

    Mayra de A. Marques

    2016-09-01

    Full Text Available Inherited myopathies affect both skeletal and cardiac muscle and are commonly associated with genetic dysfunctions, leading to the production of anomalous proteins. In cardiomyopathies, mutations frequently occur in sarcomeric genes, but the cause-effect scenario between genetic alterations and pathological processes remains elusive. Hypertrophic cardiomyopathy (HCM was the first cardiac disease associated with a genetic background. Since the discovery of the first mutation in the β-myosin heavy chain, more than 1,400 new mutations in 11 sarcomeric genes have been reported, awarding HCM the title of the disease of the sarcomere. The most common macroscopic phenotypes are left ventricle and interventricular septal thickening, but because the clinical profile of this disease is quite heterogeneous, these phenotypes are not suitable for an accurate diagnosis. The development of genomic approaches for clinical investigation allows for diagnostic progress and understanding at the molecular level. Meanwhile, the lack of accurate in vivo models to better comprehend the cellular events triggered by this pathology has become a challenge. Notwithstanding, the imbalance of Ca2+ concentrations, altered signaling pathways, induction of apoptotic factors, and heart remodeling leading to abnormal anatomy have already been reported. Of note, a misbalance of signaling biomolecules, such as kinases and tumor suppressors (e.g., Akt and p53, seems to participate in apoptotic and fibrotic events. In HCM, structural and cellular information about defective sarcomeric proteins and their altered interactome is emerging but still represents a bottleneck for developing new concepts in basic research and for future therapeutic interventions. This review focuses on the structural and cellular alterations triggered by HCM-causing mutations in troponin and tropomyosin proteins and how structural biology can aid in the discovery of new platforms for therapeutics. We

  20. Designing and modeling of complex DNA vaccine based on tropomyosin protein of Boophilus genus tick.

    Science.gov (United States)

    Ranjbar, Mohamamd Mahdi; Gupta, Shishir K; Ghorban, Khodayar; Nabian, Sedigheh; Sazmand, Alireza; Taheri, Mohammad; Esfandyari, Sahar; Taheri, Maryam

    2015-01-01

    Boophilus tick is a bloodsucking ectoparasite that transfers some pathogens, reducing production and thus leading to economical losses in the cattle industry. Tropomyosin (TPM) protein is a salivary protein, has actin regulator activity, and plays an important role in immune reactions against parasites. In the current study, besides developing a safe, effective, and broad spectrum protective measure against Boophilus genus tick based on TPM protein, we attempted to minimize possible problems occurring in the design of polytopic vaccines. Briefly, the steps that were followed in the present study were as follows: retrieving sequences and finding the mutational/conservative regions, selecting consensus and high immunogenic epitopes of B and CD4(+) T cells by different approaches, three-dimensional structure (3D structure) prediction and representation of epitopes and highly variable/conserve regions, designing vaccinal construct by fusion of B and T cell epitopes by special patterns and improving immunogenicity, evaluation of the constructs' primary structure and posttranslational modification, calculation of hydrophobic regions, reverse translation, codon optimization, open reading frame checking, insertion of start/end codon, Kozak sequence, and finally constructing the DNA vaccine. Variation plot showed some shared epitopes among the ticks' and mites' species that some might be effective only in some species. Finally, by following the steps mentioned above, two constructs for B and T cells were achieved. Checking constructs revealed their reliability and efficacy for in vitro production and utilization. Successful in silico modeling is an essential step of designing vigorous vaccines. We developed a novel protective and therapeutic vaccine against Boophilus genus (based on TPM protein). At the next step, constructed DNA vaccine would be produced in vitro and administrated to cattle, and its potency to induction of immune response and protection against Boophilus

  1. Cytoskeletal Tropomyosin Tm5NM1 Is Required for Normal Excitation–Contraction Coupling in Skeletal Muscle

    OpenAIRE

    Vlahovich, Nicole; Kee, Anthony J.; Van der Poel, Chris; Kettle, Emma; Hernandez-Deviez, Delia; Lucas, Christine; Lynch, Gordon S.; Parton, Robert G.; Gunning, Peter W.; Hardeman, Edna C.

    2009-01-01

    The functional diversity of the actin microfilaments relies in part on the actin binding protein tropomyosin (Tm). The muscle-specific Tms regulate actin-myosin interactions and hence contraction. However, there is less known about the roles of the numerous cytoskeletal isoforms. We have shown previously that a cytoskeletal Tm, Tm5NM1, defines a Z-line adjacent cytoskeleton in skeletal muscle. Recently, we identified a second cytoskeletal Tm in this region, Tm4. Here we show that Tm4 and Tm5N...

  2. An evaluation of morphological and functional multi-parametric MRI sequences in classifying non-muscle and muscle invasive bladder cancer

    International Nuclear Information System (INIS)

    Panebianco, Valeria; Barchetti, Giovanni; Grompone, Marcello Domenico; Del Monte, Maurizio; Carano, Davide; Catalano, Carlo; De Berardinis, Ettore; Leonardo, Constantino; Simone, Giuseppe; Gallucci, Michele; National Cancer Insitute, Rome; Catto, James

    2017-01-01

    Our goal is to determine the ability of multi-parametric magnetic resonance imaging (mpMRI) to differentiate muscle invasive bladder cancer (MIBC) from non-muscle invasive bladder cancer (NMIBC). Patients underwent mpMRI before tumour resection. Four MRI sets, i.e. T2-weighted (T2W) + perfusion-weighted imaging (PWI), T2W plus diffusion-weighted imaging (DWI), T2W + DWI + PWI, and T2W + DWI + PWI + dif-fusion tensor imaging (DTI) were interpreted qualitatively by two radiologists, blinded to histology results. PWI, DWI and DTI were also analysed quantitatively. Accuracy was determined using histopathology as the reference standard. A total of 82 tumours were analysed. Ninety-six percent of T1-labeled tumours by the T2W + DWI + PWI image set were confirmed to be NMIBC at histopathology. Overall accuracy of the complete mpMRI protocol was 94% in differentiating NMIBC from MIBC. PWI, DWI and DTI quantitative parameters were shown to be significantly different in cancerous versus non-cancerous areas within the bladder wall in T2-labelled lesions. MpMRI with DWI and DTI appears a reliable staging tool for bladder cancer. If our data are validated, then mpMRI could precede cystoscopic resection to allow a faster recognition of MIBC and accelerated treatment pathways. (orig.)

  3. Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration.

    Science.gov (United States)

    Fazal, Fabeha; Bijli, Kaiser M; Murrill, Matthew; Leonard, Antony; Minhajuddin, Mohammad; Anwar, Khandaker N; Finkelstein, Jacob N; Watterson, D Martin; Rahman, Arshad

    2013-01-01

    The pathogenesis of acute lung injury (ALI) involves bidirectional cooperation and close interaction between inflammatory and coagulation pathways. A key molecule linking coagulation and inflammation is the procoagulant thrombin, a serine protease whose concentration is elevated in plasma and lavage fluids of patients with ALI and acute respiratory distress syndrome (ARDS). However, little is known about the mechanism by which thrombin contributes to lung inflammatory response. In this study, we developed a new mouse model that permits investigation of lung inflammation associated with intravascular coagulation. Using this mouse model and in vitro approaches, we addressed the role of non-muscle myosin light chain kinase (nmMLCK) in thrombin-induced endothelial cell (EC) inflammation and lung neutrophil (PMN) infiltration. Our in vitro experiments revealed a key role of nmMLCK in ICAM-1 expression by its ability to control nuclear translocation and transcriptional capacity of RelA/p65 in EC. When subjected to intraperitoneal thrombin challenge, wild type mice showed a marked increase in lung PMN infiltration via expression of ICAM-1. However, these responses were markedly attenuated in mice deficient in nmMLCK. These results provide mechanistic insight into lung inflammatory response associated with intravascular coagulation and identify nmMLCK as a critical target for modulation of lung inflammation.

  4. An evaluation of morphological and functional multi-parametric MRI sequences in classifying non-muscle and muscle invasive bladder cancer

    Energy Technology Data Exchange (ETDEWEB)

    Panebianco, Valeria; Barchetti, Giovanni; Grompone, Marcello Domenico; Del Monte, Maurizio; Carano, Davide; Catalano, Carlo [Sapienza Univ. Rome (Italy). Dept. of Radiological Sciences, Oncology and Pathology; De Berardinis, Ettore; Leonardo, Constantino [Sapienza Univ. Rome (Italy). Dept. of Gynaecological-Obstetric and Urological Sciences; Simone, Giuseppe; Gallucci, Michele [' ' Regina Elena' ' National Cancer Insitute, Rome (Italy). Dept. of Urology; Catto, James [Sheffield Univ. (United Kingdom). Aademic Urology Unit

    2017-09-15

    Our goal is to determine the ability of multi-parametric magnetic resonance imaging (mpMRI) to differentiate muscle invasive bladder cancer (MIBC) from non-muscle invasive bladder cancer (NMIBC). Patients underwent mpMRI before tumour resection. Four MRI sets, i.e. T2-weighted (T2W) + perfusion-weighted imaging (PWI), T2W plus diffusion-weighted imaging (DWI), T2W + DWI + PWI, and T2W + DWI + PWI + dif-fusion tensor imaging (DTI) were interpreted qualitatively by two radiologists, blinded to histology results. PWI, DWI and DTI were also analysed quantitatively. Accuracy was determined using histopathology as the reference standard. A total of 82 tumours were analysed. Ninety-six percent of T1-labeled tumours by the T2W + DWI + PWI image set were confirmed to be NMIBC at histopathology. Overall accuracy of the complete mpMRI protocol was 94% in differentiating NMIBC from MIBC. PWI, DWI and DTI quantitative parameters were shown to be significantly different in cancerous versus non-cancerous areas within the bladder wall in T2-labelled lesions. MpMRI with DWI and DTI appears a reliable staging tool for bladder cancer. If our data are validated, then mpMRI could precede cystoscopic resection to allow a faster recognition of MIBC and accelerated treatment pathways. (orig.)

  5. Bifidobacterium infantis Potentially Alleviates Shrimp Tropomyosin-Induced Allergy by Tolerogenic Dendritic Cell-Dependent Induction of Regulatory T Cells and Alterations in Gut Microbiota

    Directory of Open Access Journals (Sweden)

    Linglin Fu

    2017-11-01

    Full Text Available Shellfish is one of the major allergen sources worldwide, and tropomyosin (Tm is the predominant allergic protein in shellfish. Probiotics has been appreciated for its beneficial effects on the host, including anti-allergic and anti-inflammatory effects, although the underlying mechanisms were not fully understood. In this study, oral administration of probiotic strain Bifidobacterium infantis 14.518 (Binf effectively suppressed Tm-induced allergic response in a mouse model by both preventive and therapeutic strategies. Further results showed that Binf stimulated dendritic cells (DCs maturation and CD103+ tolerogenic DCs accumulation in gut-associated lymphoid tissue, which subsequently induced regulatory T cells differentiation for suppressing Th2-biased response. We also found that Binf regulates the alterations of gut microbiota composition. Specifically, the increase of Dorea and decrease of Ralstonia is highly correlated with Th2/Treg ratio and may contribute to alleviating Tm-induced allergic responses. Our findings provide molecular insight into the application of Binf in alleviating food allergy and even gut immune homeostasis.

  6. Chinese herbal formula Tongluo Jiunao injection protects against cerebral ischemia by activating neurotrophin 3/tropomyosin-related kinase C pathway

    Directory of Open Access Journals (Sweden)

    Peiman Alesheikh

    2015-01-01

    Full Text Available The Chinese herbal formula Tongluo Jiunao, containing the active components Panax notoginseng and Gardenia jasminoides, has recently been patented and is in use clinically. It is known to be neuroprotective in cerebral ischemia, but the underlying pathway remains poorly understood. In the present study, we established a rat model of cerebral ischemia by occlusion of the middle cerebral artery, and administered Tongluo Jiunao, a positive control (Xuesai Tong, containing Panax notoginseng or saline intraperitoneally to investigate the pathway involved in the action of Tongluo Jiunao injection. 2,3,5-Triphenyltetrazolium chloride (TTC staining showed that the cerebral infarct area was significantly smaller in model rats that received Tongluo Jiunao than in those that received saline. Enzyme-linked immunosorbent assay revealed significantly greater expression of neurotrophin 3 and growth-associated protein 43 in ischemic cerebral tissue, and serum levels of neurotrophin 3, in the Tongluo Jiunao group than in the saline group. The reverse transcription polymerase chain reaction and immunohistochemical staining showed that after treatment with Tongluo Jiunao or Xuesai Tong, tropomyosin-related kinase C gene expression and immunoreactivity were significantly elevated compared with saline, with the greatest expression observed after Tongluo Jiunao treatment. These findings suggest that Tongluo Jiunao injection exerts a neuroprotective effect in rats with cerebral ischemia by activating the neurotrophin 3/tropomyosin-related kinase C pathway.

  7. Summary and Recommendations from the National Cancer Institute's Clinical Trials Planning Meeting on Novel Therapeutics for Non-Muscle Invasive Bladder Cancer

    NARCIS (Netherlands)

    Lerner, S.P.; Bajorin, D.F.; Dinney, C.P.; Efstathiou, J.A.; Groshen, S.; Hahn, N.M.; Hansel, D.; Kwiatkowski, D.; O'Donnell, M.; Rosenberg, J.; Svatek, R.; Abrams, J.S.; Al-Ahmadie, H.; Apolo, A.B.; Bellmunt, J.; Callahan, M.; Cha, E.K.; Drake, C.; Jarow, J.; Kamat, A.; Kim, W.; Knowles, M.; Mann, B.; Marchionni, L.; McConkey, D.; McShane, L.; Ramirez, N.; Sharabi, A.; Sharpe, A.H.; Solit, D.; Tangen, C.M.; Amiri, A.T.; Allen, E. Van; West, P.J.; Witjes, J.A.; Quale, D.Z.

    2016-01-01

    The NCI Bladder Cancer Task Force convened a Clinical Trials Planning Meeting (CTPM) Workshop focused on Novel Therapeutics for Non-Muscle Invasive Bladder Cancer (NMIBC). Meeting attendees included a broad and multi-disciplinary group of clinical and research stakeholders and included leaders from

  8. Use of Artificial Intelligence and Machine Learning Algorithms with Gene Expression Profiling to Predict Recurrent Nonmuscle Invasive Urothelial Carcinoma of the Bladder.

    Science.gov (United States)

    Bartsch, Georg; Mitra, Anirban P; Mitra, Sheetal A; Almal, Arpit A; Steven, Kenneth E; Skinner, Donald G; Fry, David W; Lenehan, Peter F; Worzel, William P; Cote, Richard J

    2016-02-01

    Due to the high recurrence risk of nonmuscle invasive urothelial carcinoma it is crucial to distinguish patients at high risk from those with indolent disease. In this study we used a machine learning algorithm to identify the genes in patients with nonmuscle invasive urothelial carcinoma at initial presentation that were most predictive of recurrence. We used the genes in a molecular signature to predict recurrence risk within 5 years after transurethral resection of bladder tumor. Whole genome profiling was performed on 112 frozen nonmuscle invasive urothelial carcinoma specimens obtained at first presentation on Human WG-6 BeadChips (Illumina®). A genetic programming algorithm was applied to evolve classifier mathematical models for outcome prediction. Cross-validation based resampling and gene use frequencies were used to identify the most prognostic genes, which were combined into rules used in a voting algorithm to predict the sample target class. Key genes were validated by quantitative polymerase chain reaction. The classifier set included 21 genes that predicted recurrence. Quantitative polymerase chain reaction was done for these genes in a subset of 100 patients. A 5-gene combined rule incorporating a voting algorithm yielded 77% sensitivity and 85% specificity to predict recurrence in the training set, and 69% and 62%, respectively, in the test set. A singular 3-gene rule was constructed that predicted recurrence with 80% sensitivity and 90% specificity in the training set, and 71% and 67%, respectively, in the test set. Using primary nonmuscle invasive urothelial carcinoma from initial occurrences genetic programming identified transcripts in reproducible fashion, which were predictive of recurrence. These findings could potentially impact nonmuscle invasive urothelial carcinoma management. Copyright © 2016 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  9. Localization of brain-derived neurotrophic factor, neurotrophin-4, tropomyosin-related kinase b receptor, and p75 NTR receptor by high-resolution immunohistochemistry on the adult mouse neuromuscular junction.

    Science.gov (United States)

    Garcia, Neus; Tomàs, Marta; Santafe, Manel M; Lanuza, M Angel; Besalduch, Nuria; Tomàs, Josep

    2010-03-01

    Neurotrophins and their receptors, the trk receptor tyrosine kinases (trks) and p75(NTR), are differentially expressed among the cell types that make up synapses. It is important to determine the precise location of these molecules involved in neurotransmission. Here we use immunostaining and Western blotting to study the localization and expression of neurotrophin brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) and the receptors tropomyosin-related kinase b (trkB) and p75(NTR) at the adult neuromuscular junction. Our confocal immunofluorescence results on the whole mounts of the mouse Levator auris longus muscle and on semithin cross-sections showed that BDNF, NT-4, trkB, and p75(NTR) were localized on the three cells in the neuromuscular synapse (motor axons, post-synaptic muscle and Schwann cells).

  10. Clinical usefulness of random biopsies in diagnosis and treatment of non-muscle invasive bladder cancer: Systematic review and meta-analysis.

    Science.gov (United States)

    Subiela, J D; Palou, J; Esquinas, C; Fernández Gómez, J M; Rodríguez Faba, O

    2017-11-20

    This systematic review of the literature has been focused on determining the clinical usefulness of random bladder biopsies (RB) in the diagnosis of carcinoma in situ. A meta-analysis was performed to establish the clinic and pathological factors associated to positive biopsies. A systematic review was performed using Pubmed/Medline database according to the PRISMA guidelines. Thirty-seven articles were included, recruiting a total of 12,657 patients, 10,975 were submitted to RB. The overall incidence of positive RB was 21.91%. Significant differences were found in the incidence of positive RB when patients were stratified according to urine cytology result, tumor multiplicity, tumor appearance, stage and grade. The results of the meta-analysis revealed that the presence of positive cytology, tumor multiplicity, non-papillary appearance tumors, stage T1 and histological grades G2 and G3 represent the risk factors to predict abnormalities in RB. The incidence of positive RB in patients with non-muscle invasive bladder cancer was 21.91%. The maximum usefulness of RB was observed when these are performed in a standardized way. The results of the meta-analysis showed that besides positive cytology and non-papillary appearance tumors, tumor multiplicity and histological grades G2 and G3 represent risk factors associated to positive RB, suggesting that the use of RB might be extensive to the intermediate risk group of the European Organization for Research and Treatment of Cancer (EORTC). Copyright © 2017 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

  11. Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease

    DEFF Research Database (Denmark)

    Pecci, A.; Panza, E.; Pujol-Moix, N.

    2008-01-01

    MYH9-related disease (MYH9-RD) is a rare autosomal-dominant disorder caused by mutations in MYH9, the gene for the heavy chain of nonmuscle myosin IIA (NMMHC-IIA). All patients present from birth with macrothrombocytopenia, but in infancy or adult life, some of them develop sensorineural deafness...... to 50 unrelated pedigrees. The risk of noncongenital manifestations associated with different genotypes was estimated over time by event-free survival analysis. We demonstrated that all subjects with mutations in the motor domain of NMMHC-IIA present with severe thrombocytopenia and develop nephritis...... and deafness before the age of 40 years, while those with mutations in the tail domain have a much lower risk of noncongenital complications and significantly higher platelet counts. We also evaluated the clinical course of patients with mutations in the four most frequently affected residues of NMMHC...

  12. Renin-Angiotensin Inhibitors Decrease Recurrence after Transurethral Resection of Bladder Tumor in Patients with Nonmuscle Invasive Bladder Cancer.

    Science.gov (United States)

    Blute, Michael L; Rushmer, Timothy J; Shi, Fangfang; Fuller, Benjamin J; Abel, E Jason; Jarrard, David F; Downs, Tracy M

    2015-11-01

    Prior reports suggest that renin-angiotensin system inhibition may decrease nonmuscle invasive bladder cancer recurrence. We evaluated whether angiotensin converting enzyme inhibitor or angiotensin receptor blocker treatment at initial surgery was associated with decreased recurrence or progression in patients with nonmuscle invasive bladder cancer. Using an institutional bladder cancer database we identified 340 patients with data available on initial transurethral resection of bladder tumor. Progression was defined as an increase to stage T2. Cox proportional hazards models were used to evaluate associations with recurrence-free and progression-free survival. Median patient age was 69.6 years. During a median followup of 3 years (IQR 1.3-6.1) 200 patients (59%) had recurrence and 14 (4.1%) had stage progression. Of those patients 143 were receiving angiotensin converting enzyme inhibitor/angiotensin receptor blockers at the time of the first transurethral resection. On univariate analysis factors associated with improved recurrence-free survival included carcinoma in situ (p = 0.040), bacillus Calmette-Guérin therapy (p = 0.003) and angiotensin converting enzyme inhibitor/angiotensin receptor blocker therapy (p = 0.009). Multivariate analysis demonstrated that patients treated with bacillus Calmette-Guérin therapy (HR 0.68, 95% CI 0.47-0.87, p = 0.002) or angiotensin converting enzyme inhibitor/angiotensin receptor blocker therapy (HR 0.61, 95% CI 0.45-0.84, p = 0.005) were less likely to experience tumor recurrence. The 5-year recurrence-free survival rate was 45.6% for patients treated with angiotensin converting enzyme inhibitor/angiotensin receptor blockers and 28.1% in those not treated with angiotensin converting enzyme inhibitor/angiotensin receptor blockers (p = 0.009). Subgroup analysis was performed to evaluate nonmuscle invasive bladder cancer pathology (Ta, T1 and carcinoma in situ) in 85 patients on bacillus Calmette-Guérin therapy alone and in

  13. p53 Status correlates with the risk of recurrence in non-muscle invasive bladder cancers treated with Bacillus Calmette-Guérin: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Xiaofeng Zhou

    Full Text Available Published studies have yielded inconsistent results on the relationship between p53 status and the prognosis of non-muscle invasive bladder cancer (NMIBC treated with Bacillus Calmette-Guérin (BCG intravesical therapy. Therefore, we performed a meta-analysis to evaluate the prognostic value of p53 in NMIBC treated with BCG.We systematically searched for relevant literature in PubMed, EMBASE, CNKI, and Chinese Wanfang databases. Hazard ratios (HRs with 95% confidence intervals (CIs were combined as the effect size (ES across studies for recurrence-free survival (RFS and progression-free survival (PFS.A total of 11 studies, consisting of 1,049 participants, met the criteria. Overall, there was no clear relationship between p53 status and RFS or PFS for NMIBC patients treated with BCG (HR: 1.40, 95% CI: 0.91-2.16; HR: 1.37, 95% CI: 0.90-2.09, respectively. Obvious heterogeneity was observed across the studies (I2 = 69.5%, P = 0.001; I2 = 44.7%, P = 0.081, respectively. In stratified analysis by region, p53 overexpression was a predictor of poor RFS in Asian populations (HR: 1.57, 95% CI: 1.08-2.27. In addition, after excluding the studies that possibly contributed to the heterogeneity by the Galbraith plot, the overall association for RFS became statistically significant (HR: 1.38 95% CI: 1.08-1.77 without evidence of heterogeneity (I2 = 0.0%, P = 0.499.This meta-analysis suggests that p53 overexpression in NMIBC patients treated with BCG may be associated with RFS, especially in Asian populations. Because of the heterogeneity and other limitations, further studies with rigid criteria and large populations are still warranted to confirm our findings.

  14. Nonmuscle myosin heavy chain IIA is a critical factor contributing to the efficiency of early infection of severe fever with thrombocytopenia syndrome virus.

    Science.gov (United States)

    Sun, Yinyan; Qi, Yonghe; Liu, Chenxuan; Gao, Wenqing; Chen, Pan; Fu, Liran; Peng, Bo; Wang, Haimin; Jing, Zhiyi; Zhong, Guocai; Li, Wenhui

    2014-01-01

    Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel phlebovirus in the Bunyaviridae family. Most patients infected by SFTSV present with fever and thrombocytopenia, and up to 30% die due to multiple-organ dysfunction. The mechanisms by which SFTSV enters multiple cell types are unknown. SFTSV contains two species of envelope glycoproteins, Gn (44.2 kDa) and Gc (56 kDa), both of which are encoded by the M segment and are cleaved from a precursor polypeptide (about 116 kDa) in the endoplasmic reticulum (ER). Gn fused with an immunoglobulin Fc tag at its C terminus (Gn-Fc) bound to multiple cells susceptible to the infection of SFTSV and blocked viral infection of human umbilical vein endothelial cells (HUVECs). Immunoprecipitation assays following mass spectrometry analysis showed that Gn binds to nonmuscle myosin heavy chain IIA (NMMHC-IIA), a cellular protein with surface expression in multiple cell types. Small interfering RNA (siRNA) knockdown of NMMHC-IIA, but not the closely related NMMHC-IIB or NMMHC-IIC, reduced SFTSV infection, and NMMHC-IIA specific antibody blocked infection by SFTSV but not other control viruses. Overexpression of NMMHC-IIA in HeLa cells, which show limited susceptivity to SFTSV, markedly enhanced SFTSV infection of the cells. These results show that NMMHC-IIA is critical for the cellular entry of SFTSV. As NMMHC-IIA is essential for the normal functions of platelets and human vascular endothelial cells, it is conceivable that NMMHC-IIA directly contributes to the pathogenesis of SFTSV and may be a useful target for antiviral interventions against the viral infection.

  15. HumanMethylation450K Array–Identified Biomarkers Predict Tumour Recurrence/Progression at Initial Diagnosis of High-risk Non-muscle Invasive Bladder Cancer

    Directory of Open Access Journals (Sweden)

    Mark O Kitchen

    2018-01-01

    Full Text Available Background: High-risk non-muscle invasive bladder cancer (HR-NMIBC is a clinically unpredictable disease. Despite clinical risk estimation tools, many patients are undertreated with intra-vesical therapies alone, whereas others may be over-treated with early radical surgery. Molecular biomarkers, particularly DNA methylation, have been reported as predictive of tumour/patient outcomes in numerous solid organ and haematologic malignancies; however, there are few reports in HR-NMIBC and none using genome-wide array assessment. We therefore sought to identify novel DNA methylation markers of HR-NMIBC clinical outcomes that might predict tumour behaviour at initial diagnosis and help guide patient management. Patients and methods: A total of 21 primary initial diagnosis HR-NMIBC tumours were analysed by Illumina HumanMethylation450 BeadChip arrays and subsequently bisulphite Pyrosequencing. In all, 7 had not recurred at 1 year after resection and 14 had recurred and/or progressed despite intra-vesical BCG. A further independent cohort of 32 HR-NMIBC tumours (17 no recurrence and 15 recurrence and/or progression despite BCG were also assessed by bisulphite Pyrosequencing. Results: Array analyses identified 206 CpG loci that segregated non-recurrent HR-NMIBC tumours from clinically more aggressive recurrence/progression tumours. Hypermethylation of CpG cg11850659 and hypomethylation of CpG cg01149192 in combination predicted HR-NMIBC recurrence and/or progression within 1 year of diagnosis with 83% sensitivity, 79% specificity, and 83% positive and 79% negative predictive values. Conclusions: This is the first genome-wide DNA methylation analysis of a unique HR-NMIBC tumour cohort encompassing known 1-year clinical outcomes. Our analyses identified potential novel epigenetic markers that could help guide individual patient management in this clinically unpredictable disease.

  16. Effectivity of intravescical thermo-chemotherapy prophylaxis for patients with high recurrence and progression risk for non-muscle invasive bladder cancer

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    Ali Serdar Gözen

    2017-06-01

    Full Text Available Background&Aim: High grade non-muscle invasive bladder cancer (NMIBC is common in urological practice. Most of these cancers are or become refractory to intravesical immunotherapy and chemotherapy. Here we evaluated the efficacy of combined local bladder hyperthermia and intravesical mitomycin-C (MMC instillation in patients with high-risk recurrent NMIBC. Materials and methods: Between February 2014 and December 2015, 18 patients with high risk NMIBC were enrolled. Patients were treated in an outpatient basis with 6 weekly induction sessions followed by monthly maintenance sessions with intravesical MMC in local hyperthermia with bladder wall thermo-chemotherapy (BWT system (PelvixTT system, Elmedical Ltd., Hod Hasharon, Israel. The follow-up regimen included cystoscopy after the induction cycle and thereafter with regular intervals. Time to disease recurrence was defined as time from the first intravesical treatment to endoscopic or histological documentation of a new bladder tumour. Adverse events were recorded according to CTC 4.0 (Common Toxicity Criteria score system. Results: Mean age was 72 (32-87 years. 10 patients had multifocal disease, 9 had CIS, 6 had recurrent disease and 2 had highly recurrent disease (> 3 recurrences in a 24 months period. 6 patients underwent previous intravesical chemotherapy with MMC. The average number of maintenance sessions per patient was 7.6. After a mean follow-up of 433 days, 15 patients (83.3% were recurrence-free. 3 patients had tumour recurrence after a mean period of 248 days without progression. Side effects were limited to grade 1 in 2 patients and grade 2 in 1 patient. Conclusions: BWT seems to be feasible and safe in high grade NMIBC. More studies are needed to identify the subgroup of patients who may benefit more from this treatment.

  17. Polymorphisms in the non-muscle myosin heavy chain gene (MYH9 are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa.

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    Tandi Edith Matsha

    Full Text Available OBJECTIVE: Though single nucleotide polymorphisms (SNPs in the non-muscle myosin gene (MYH9 have been reported to explain most of the excess risk of nondiabetic chronic kidney disease (CKD, in African-Americans, some studies have also shown associations with diabetic end-stage renal disease. We investigated the association of MYH9 SNPs with renal traits in a mixed-ancestry South African population prone to diabetes. RESEARCH DESIGN AND METHODS: Three SNPs known to be associated with CKD (rs4821480, rs5756152 and rs12107 were genotyped using Taqman assay in 716 adults (198 with diabetes from the Bellville-South community, Cape Town. Glomerular filtration rate was estimated (eGFR and urinary albumin/creatinine ratio (ACR assessed. Multivariable regressions were used to relate the SNPs with renal traits. RESULTS: Mean age was 53.6 years, with the expected differences observed in characteristics by diabetic status. Significant associations were found between rs575152 and serum creatinine, and eGFR in the total population, and in diabetic participants (all p≤0.003, but not in non-diabetics (all p≥0.16, with significant interactions by diabetes status (interaction-p≤0.009. The association with ACR was borderline in diabetic participants (p = 0.05 and non-significant in non-diabetics (p = 0.85, with significant interaction (interaction p = 0.02. rs12107 was associated with fasting-, 2-hour glucose and HbA1c in diabetic participants only (interaction-p≤0.003, but not with renal traits. CONCLUSION: MYH9 SNPs were associated with renal traits only in diabetic participants in this population. Our findings and other studies suggest that MYH9 may have a broader genetic risk effect on kidney diseases.

  18. Regulation of actomyosin ATPase activity by troponin-tropomyosin: effect of the binding of the myosin subfragment 1 (S-1) ATP complex

    International Nuclear Information System (INIS)

    Greene, L.E.; Williams, D.L. Jr.; Eisenberg, E.

    1987-01-01

    In the authors' model of regulation, the observed lack of cooperativity in the binding of myosin subfragment 1 (S-1) with bound ATP to the troponin-tropomyosin-actin complex (regulated actin) is explained by S-1 ATP having about the same affinity for the conformation of the regulated actin that activates the myosin ATPase activity (turned-on form) and the conformation that does not activate the myosin ATPase activity (turned-off form). This predicts that, in the absence of Ca 2+ , S-1 ATP should not turn on the regulated actin filament. In the present study, they tested this prediction by using either unmodified S-1 or S-1 chemically modified with N,N'-p-phenylenedimaleimide (pPDM S-1) so that functionally it acts like S-1 ATP, although it does not hydrolyze ATP. [ 14 C]pPDM and [ 32 P]ATP were used as tracers. They found that, in the absence of Ca 2+ , neither S-1 ATP nor pPDM S-1 ATP significantly turns on the ATPase activity of the regulated complex of actin and S-1 (acto S-1). In contrast, in the presence of Ca 2+ , pPDM S-1 ATP binding almost completely turns on the regulated acto S-1 ATPase activity. These results can be explained by their original cooperativity model, with pPDM S-1 ATP binding only ≅ 2 fold more strongly to the turned-on form that to the turned-off form of regulated actin. However, the results are not consistent with our alternative model, which predicts that if pPDM S-1 ATP binds to actin in the absence of Ca 2+ but does not turn on the ATPase activity, then it should also turn on the ATPase activity in the presence of Ca 2+

  19. Comparative Statistical Mechanics of Muscle and Non-Muscle Contractile Systems: Stationary States of Near-Equilibrium Systems in A Linear Regime

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    Yves Lecarpentier

    2017-10-01

    Full Text Available A. Huxley’s equations were used to determine the mechanical properties of muscle myosin II (MII at the molecular level, as well as the probability of the occurrence of the different stages in the actin–myosin cycle. It was then possible to use the formalism of statistical mechanics with the grand canonical ensemble to calculate numerous thermodynamic parameters such as entropy, internal energy, affinity, thermodynamic flow, thermodynamic force, and entropy production rate. This allows us to compare the thermodynamic parameters of a non-muscle contractile system, such as the normal human placenta, with those of different striated skeletal muscles (soleus and extensor digitalis longus as well as the heart muscle and smooth muscles (trachea and uterus in the rat. In the human placental tissues, it was observed that the kinetics of the actin–myosin crossbridges were considerably slow compared with those of smooth and striated muscular systems. The entropy production rate was also particularly low in the human placental tissues, as compared with that observed in smooth and striated muscular systems. This is partly due to the low thermodynamic flow found in the human placental tissues. However, the unitary force of non-muscle myosin (NMII generated by each crossbridge cycle in the myofibroblasts of the human placental tissues was similar in magnitude to that of MII in the myocytes of both smooth and striated muscle cells. Statistical mechanics represents a powerful tool for studying the thermodynamics of all contractile muscle and non-muscle systems.

  20. Dlc1 interaction with non-muscle myosin heavy chain II-A (Myh9 and Rac1 activation

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    Mohammad G. Sabbir

    2016-04-01

    Full Text Available The Deleted in liver cancer 1 (Dlc1 gene codes for a Rho GTPase-activating protein that also acts as a tumour suppressor gene. Several studies have consistently found that overexpression leads to excessive cell elongation, cytoskeleton changes and subsequent cell death. However, none of these studies have been able to satisfactorily explain the Dlc1-induced cell morphological phenotypes and the function of the different Dlc1 isoforms. Therefore, we have studied the interacting proteins associated with the three major Dlc1 transcriptional isoforms using a mass spectrometric approach in Dlc1 overexpressing cells. We have found and validated novel interacting partners in constitutive Dlc1-expressing cells. Our study has shown that Dlc1 interacts with non-muscle myosin heavy chain II-A (Myh9, plectin and spectrin proteins in different multiprotein complexes. Overexpression of Dlc1 led to increased phosphorylation of Myh9 protein and activation of Rac1 GTPase. These data support a role for Dlc1 in induced cell elongation morphology and provide some molecular targets for further analysis of this phenotype.

  1. Molecular markers in disease detection and follow-up of patients with non-muscle invasive bladder cancer.

    Science.gov (United States)

    Maas, Moritz; Walz, Simon; Stühler, Viktoria; Aufderklamm, Stefan; Rausch, Steffen; Bedke, Jens; Stenzl, Arnulf; Todenhöfer, Tilman

    2018-05-01

    Diagnosis and surveillance of non-muscle invasive bladder cancer (NMIBC) is mainly based on endoscopic bladder evaluation and urine cytology. Several assays for determining additional molecular markers (urine-, tissue- or blood-based) have been developed in recent years but have not been included in clinical guidelines so far. Areas covered: This review gives an update on different molecular markers in the urine and evaluates their role in patients with NMIBC in disease detection and surveillance. Moreover, the potential of recent approaches such as DNA methylation assays, multi-panel RNA gene expression assays and cell-free DNA analysis is assessed. Expert commentary: Most studies on various molecular urine markers have mainly focused on a potential replacement of cystoscopy. New developments in high throughput technologies and urine markers may offer further advantages as they may represent a non-invasive approach for molecular characterization of the disease. This opens new options for individualized surveillance strategies and may help to choose the best therapeutic option. The implementation of these technologies in well-designed clinical trials is essential to further promote the use of urine diagnostics in the management of patients with NMIBC.

  2. Inflammatory Adipokines Decrease Expression of Two High Molecular Weight Isoforms of Tropomyosin Similar to the Change in Type 2 Diabetic Patients.

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    Stuart A Savill

    Full Text Available Cardiovascular disease and cancer are increased in Type 2 diabetes. TPM1 and TPM4 genes encode proteins associated with cardiovascular and neoplastic disease. High (HMW and low (LMW molecular weight isoforms from TPM1 and TPM4 are altered in several cancer cells and the 3'UTR of TPM1 mRNA is tumour suppressive. Leukocytes influence cardiovascular and neoplastic disease by immunosurveillance for cancer and by chronic inflammation in Type 2 diabetes and cardiovascular disease. The aim was to determine changes in expression of isoforms from TPM1 and TPM4 genes in leukocytes from Type 2 diabetic patients and to use the leukocyte cell line THP1 to identify possible mediators of changes in the patients. Gene expression was determined by RT-qPCR. In diabetes, expression of HMW isoforms from TPM1 were markedly decreased (0.55 v 1.00; p = 0.019 but HMW isoforms from TPM4 were not significantly different (0.76 v 1.00; p = 0.205. Within individual variance in expression of HMW isoforms was very high. The change in expression in HMW isoforms from TPM1 and TPM4 was replicated in THP1 cells treated with 1 ng/ml TNFα (0.10 and 0.12 v 1.00 respectively or 10 ng/ml IL-1α (0.17 and 0.14 v 1.00 respectively. Increased insulin or glucose concentrations had no substantial effects on TPM1 or TPM4 expression. Decreased TPM1 mRNA resulted in decreases in HMW protein levels. Expression of HMW isoforms from TPM1 is decreased in Type 2 diabetes. This is probably due to increased levels of inflammatory cytokines TNFα and IL-1α in Type 2 diabetes. Lower levels of TPM1 mRNA reduce tumour suppression and could contribute to increased cancer risk in Type 2 diabetes. Decreased HMW tropomyosin isoforms are associated with cancer. Decreased HMW isoforms give rise to cells that are more plastic, motile, invasive and prone to dedifferentiation resulting in leukocytes that are more invasive but less functionally effective.

  3. Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion

    Energy Technology Data Exchange (ETDEWEB)

    Wasik, Anita A.; Dumont, Vincent [Department of Pathology, University of Helsinki, 00014 Helsinki (Finland); Tienari, Jukka [Department of Pathology, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, 05850 Hyvinkää (Finland); Nyman, Tuula A. [Institute of Biotechnology, University of Helsinki, 00014 Helsinki (Finland); Fogarty, Christopher L.; Forsblom, Carol; Lehto, Markku [Folkhälsan Institute of Genetics, Folkhälsan Research Center, 00290 Helsinki (Finland); Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, 000290 Helsinki (Finland); Diabetes& Obesity Research Program, Research Program´s Unit, 00014 University of Helsinki (Finland); Lehtonen, Eero [Department of Pathology, University of Helsinki, 00014 Helsinki (Finland); Laboratory Animal Centre, University of Helsinki, 00014 Helsinki (Finland); Groop, Per-Henrik [Folkhälsan Institute of Genetics, Folkhälsan Research Center, 00290 Helsinki (Finland); Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, 000290 Helsinki (Finland); Diabetes& Obesity Research Program, Research Program´s Unit, 00014 University of Helsinki (Finland); Baker IDI Heart & Diabetes Institute, 3004 Melbourne (Australia); Lehtonen, Sanna, E-mail: sanna.h.lehtonen@helsinki.fi [Department of Pathology, University of Helsinki, 00014 Helsinki (Finland)

    2017-01-15

    Glomerular epithelial cells, podocytes, are insulin responsive and can develop insulin resistance. Here, we demonstrate that the small GTPase septin 7 forms a complex with nonmuscle myosin heavy chain IIA (NMHC-IIA; encoded by MYH9), a component of the nonmuscle myosin IIA (NM-IIA) hexameric complex. We observed that knockdown of NMHC-IIA decreases insulin-stimulated glucose uptake into podocytes. Both septin 7 and NM-IIA associate with SNAP23, a SNARE protein involved in GLUT4 storage vesicle (GSV) docking and fusion with the plasma membrane. We observed that insulin decreases the level of septin 7 and increases the activity of NM-IIA in the SNAP23 complex, as visualized by increased phosphorylation of myosin regulatory light chain. Also knockdown of septin 7 increases the activity of NM-IIA in the complex. The activity of NM-IIA is increased in diabetic rat glomeruli and cultured human podocytes exposed to macroalbuminuric sera from patients with type 1 diabetes. Collectively, the data suggest that the activity of NM-IIA in the SNAP23 complex plays a key role in insulin-stimulated glucose uptake into podocytes. Furthermore, we observed that septin 7 reduces the activity of NM-IIA in the SNAP23 complex and thereby hinders GSV docking and fusion with the plasma membrane. - Highlights: • Septin 7, nonmuscle myosin heavy chain IIA (NMHC-IIA) and SNAP23 form a complex. • Knockdown of septin 7 increases NM-IIA activity in the SNAP23 complex. • Insulin decreases septin 7 level and increases NM-IIA activity in the SNAP23 complex. • Septin 7 hinders GSV docking/fusion by reducing NM-IIA activity in the SNAP23 complex.

  4. Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion

    International Nuclear Information System (INIS)

    Wasik, Anita A.; Dumont, Vincent; Tienari, Jukka; Nyman, Tuula A.; Fogarty, Christopher L.; Forsblom, Carol; Lehto, Markku; Lehtonen, Eero; Groop, Per-Henrik; Lehtonen, Sanna

    2017-01-01

    Glomerular epithelial cells, podocytes, are insulin responsive and can develop insulin resistance. Here, we demonstrate that the small GTPase septin 7 forms a complex with nonmuscle myosin heavy chain IIA (NMHC-IIA; encoded by MYH9), a component of the nonmuscle myosin IIA (NM-IIA) hexameric complex. We observed that knockdown of NMHC-IIA decreases insulin-stimulated glucose uptake into podocytes. Both septin 7 and NM-IIA associate with SNAP23, a SNARE protein involved in GLUT4 storage vesicle (GSV) docking and fusion with the plasma membrane. We observed that insulin decreases the level of septin 7 and increases the activity of NM-IIA in the SNAP23 complex, as visualized by increased phosphorylation of myosin regulatory light chain. Also knockdown of septin 7 increases the activity of NM-IIA in the complex. The activity of NM-IIA is increased in diabetic rat glomeruli and cultured human podocytes exposed to macroalbuminuric sera from patients with type 1 diabetes. Collectively, the data suggest that the activity of NM-IIA in the SNAP23 complex plays a key role in insulin-stimulated glucose uptake into podocytes. Furthermore, we observed that septin 7 reduces the activity of NM-IIA in the SNAP23 complex and thereby hinders GSV docking and fusion with the plasma membrane. - Highlights: • Septin 7, nonmuscle myosin heavy chain IIA (NMHC-IIA) and SNAP23 form a complex. • Knockdown of septin 7 increases NM-IIA activity in the SNAP23 complex. • Insulin decreases septin 7 level and increases NM-IIA activity in the SNAP23 complex. • Septin 7 hinders GSV docking/fusion by reducing NM-IIA activity in the SNAP23 complex.

  5. Systemic Immunotherapy of Non-Muscle Invasive Mouse Bladder Cancer with Avelumab, an Anti-PD-L1 Immune Checkpoint Inhibitor.

    Science.gov (United States)

    Vandeveer, Amanda J; Fallon, Jonathan K; Tighe, Robert; Sabzevari, Helen; Schlom, Jeffrey; Greiner, John W

    2016-05-01

    Bacillus Calmette-Guerin (BCG) is the standard of care for intravesical therapy for carcinoma in situ and non-muscle invasive, nonmetastatic human urothelial carcinoma. Although the responsiveness to this immunotherapeutic is believed to be linked with (i) a high number of somatic mutations and (ii) a large number of tumor-infiltrating lymphocytes, recent findings of the roles that inhibitory immune receptors and their ligands play in tumor evasion may provide insights into the limitations of the effectiveness of BCG and offer new targets for immune-based therapy. In this study, an aggressive, bioluminescent orthotopic bladder cancer model, MB49 tumor cells transfected with luciferase (MB49(luc)), was used to study the antitumor effects of avelumab, an antibody to PD-L1. MB49(luc) murine tumor cells form multifocal tumors on the mucosal wall of the bladder reminiscent of non-muscle invasive, nonmetastatic urothelial carcinomas. MB49(luc) bladder tumors are highly positive for the expression of PD-L1, and avelumab administration induced significant (P < 0.05) antitumor effects. These antitumor effects were more dependent on the presence of CD4 than CD8 T cells, as determined by in vivo immune cell depletions. The findings suggest that in this bladder tumor model, interruption of the immune-suppressive PD-1/PD-L1 complex releases a local adaptive immune response that, in turn, reduces tumor growth. This bladder tumor model can be used to further identify host antitumor immune mechanisms and evaluate combinations of immune-based therapies for carcinoma in situ and non-muscle invasive, nonmetastatic urothelial carcinoma, to provide the rationale for subsequent clinical studies. Cancer Immunol Res; 4(5); 452-62. ©2016 AACR. ©2016 American Association for Cancer Research.

  6. Genes influenced by the non-muscle isoform of Myosin light chain kinase impact human cancer prognosis.

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    Tong Zhou

    Full Text Available The multifunctional non-muscle isoform of myosin light chain kinase (nmMLCK is critical to the rapid dynamic coordination of the cytoskeleton involved in cancer cell proliferation and migration. We identified 45 nmMLCK-influenced genes by bioinformatic filtering of genome-wide expression in wild type and nmMLCK knockout (KO mice exposed to preclinical models of murine acute inflammatory lung injury, pathologies that are well established to include nmMLCK as an essential participant. To determine whether these nmMLCK-influenced genes were relevant to human cancers, the 45 mouse genes were matched to 38 distinct human orthologs (M38 signature (GeneCards definition and underwent Kaplan-Meier survival analysis in training and validation cohorts. These studies revealed that in training cohorts, the M38 signature successfully identified cancer patients with poor overall survival in breast cancer (P<0.001, colon cancer (P<0.001, glioma (P<0.001, and lung cancer (P<0.001. In validation cohorts, the M38 signature demonstrated significantly reduced overall survival for high-score patients of breast cancer (P = 0.002, colon cancer (P = 0.035, glioma (P = 0.023, and lung cancer (P = 0.023. The association between M38 risk score and overall survival was confirmed by univariate Cox proportional hazard analysis of overall survival in the both training and validation cohorts. This study, providing a novel prognostic cancer gene signature derived from a murine model of nmMLCK-associated lung inflammation, strongly supports nmMLCK-involved pathways in tumor growth and progression in human cancers and nmMLCK as an attractive candidate molecular target in both inflammatory and neoplastic processes.

  7. Autoimmunity to Tropomyosin-Specific Peptides Induced by Mycobacterium leprae in Leprosy Patients: Identification of Mimicking Proteins.

    Science.gov (United States)

    Singh, Itu; Yadav, Asha Ram; Mohanty, Keshar Kunja; Katoch, Kiran; Sharma, Prashant; Pathak, Vinay Kumar; Bisht, Deepa; Gupta, Umesh D; Sengupta, Utpal

    2018-01-01

    It has been shown earlier that there is a rise in the levels of autoantibodies and T cell response to cytoskeletal proteins in leprosy. Our group recently demonstrated a rise in both T and B cell responses to keratin and myelin basic protein in all types of leprosy patients and their associations in type 1 reaction (T1R) group of leprosy. In this study, we investigated the association of levels of autoantibodies and lymphoproliferation against myosin in leprosy patients across the spectrum and tried to find out the mimicking proteins or epitopes between host protein and protein/s of Mycobacterium leprae . One hundred and sixty-nine leprosy patients and 55 healthy controls (HC) were enrolled in the present study. Levels of anti-myosin antibodies and T-cell responses against myosin were measured by ELISA and lymphoproliferation assay, respectively. Using 2-D gel electrophoresis, western blot and MALDI-TOF/TOF antibody-reactive spots were identified. Three-dimensional structure of mimicking proteins was modeled by online server. B cell epitopes of the proteins were predicted by BCPREDS server 1.0 followed by identification of mimicking epitopes. Mice of inbred BALB/c strain were hyperimmunized with M. leprae soluble antigen (MLSA) and splenocytes and lymph node cells of these animals were adoptively transferred to naïve mice. Highest level of anti-myosin antibodies was noted in sera of T1R leprosy patients. We observed significantly higher levels of lymphoproliferative response ( p  leprae . We found four mimicking epitopes between these sequences. These data suggest that these mimicking proteins tropomyosin and ATP-dependent Clp protease ATP-binding subunit of M. leprae or more precisely mimicking epitopes (four B cell epitopes) might be responsible for extensive tissue damage during type1 reaction in leprosy.

  8. Role of tropomyosin as a cross-reacting allergen in sensitization to cockroach in patients from Martinique (French Caribbean island) with a respiratory allergy to mite and a food allergy to crab and shrimp

    NARCIS (Netherlands)

    Purohit, A.; Shao, J.; Degreef, J. M.; van Leeuwen, A.; van Ree, R.; Pauli, G.; de Blay, F.

    2007-01-01

    BACKGROUND: Tropomyosin has been described as cross-reacting allergen between mite, cockroach and shrimp. METHODS: In 13 patients with asthma and/or rhinitis sensitized to mite and/or German cockroach and presenting urticaria, oral allergy syndrome or angio-edema upon eating shrimp and/or crab, we

  9. Fisetin provides antidepressant effects by activating the tropomyosin receptor kinase B signal pathway in mice.

    Science.gov (United States)

    Wang, Yamin; Wang, Bin; Lu, Jiaqi; Shi, Haixia; Gong, Siyi; Wang, Yufan; Hamdy, Ronald C; Chua, Balvin H L; Yang, Lingli; Xu, Xingshun

    2017-12-01

    Depression has been associated with a low-grade chronic inflammatory state, suggesting a potential therapeutic role for anti-inflammatory agents. Fisetin is a naturally occurring flavonoid in strawberries that has anti-inflammatory activities, but whether fisetin has antidepressant effects is unknown. In this study, we exposed mice to spatial restraint for 2 weeks with or without treatment with fisetin. Immobility time in the forced swimming and tail suspension test after this restraint increased in the untreated group, but this increase did not occur in the fisetin group. We administered fisetin to Abelson helper integration site-1 (Ahi1) knockout mice, which have depressive phenotypes. We found that fisetin attenuated the depressive phenotype of these Ahi1 knockout mice. We further investigated the potential mechanism of fisetin's antidepressant effects. Because TrkB is a critical signaling pathway in the mechanisms of depression, we examined whether phosphorylated TrkB was involved in the antidepressant effects of fisetin. We found that fisetin increased phosphorylated TrkB level without altering total TrkB; this increase was attenuated by K252a, a specific TrkB inhibitor. Taken together, our results demonstrated that fisetin may have therapeutic potential for treating depression and that this antidepressant effect may be mediated by the activation of the TrkB signaling pathway. © 2017 International Society for Neurochemistry.

  10. CD73 Predicts Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer

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    Marian S. Wettstein

    2015-01-01

    Full Text Available Aims. CD73 is a membrane associated 5′-ectonucleotidase that has been proposed as prognostic biomarker in various solid tumors. The aim of this study is to evaluate CD73 expression in a cohort of patients with primary bladder cancer in regard to its association with clinicopathological features and disease course. Methods. Tissue samples from 174 patients with a primary urothelial carcinoma were immunohistochemically assessed on a tissue microarray. Associations between CD73 expression and retrospectively obtained clinicopathological data were evaluated by contingency analysis. Survival analysis was performed to investigate the predictive value of CD73 within the subgroup of pTa and pT1 tumors in regard to progression-free survival (PFS. Results. High CD73 expression was found in 46 (26.4% patients and was significantly associated with lower stage, lower grade, less adjacent carcinoma in situ and with lower Ki-67 proliferation index. High CD73 immunoreactivity in the subgroup of pTa and pT1 tumors (n=158 was significantly associated with longer PFS (HR: 0.228; p=0.047 in univariable Cox regression analysis. Conclusion. High CD73 immunoreactivity was associated with favorable clinicopathological features. Furthermore, it predicts better outcome in the subgroup of pTa and pT1 tumors and may thus serve as additional tool for the selection of patients with favorable prognosis.

  11. Alterations in ubiquitin ligase Siah-2 and its corepressor N-CoR after P-MAPA immunotherapy and anti-androgen therapy: new therapeutic opportunities for non-muscle invasive bladder cancer.

    Science.gov (United States)

    Garcia, Patrick Vianna; Apolinário, Letícia Montanholi; Böckelmann, Petra Karla; da Silva Nunes, Iseu; Duran, Nelson; Fávaro, Wagner José

    2015-01-01

    The present study describes the role of the ubiquitin ligase Siah-2 and corepressor N-CoR in controlling androgen receptor (AR) and estrogen receptors (ERα and ERβ) signaling in an appropriate animal model (Fischer 344 female rats) of non-muscle invasive bladder cancer (NMIBC), especially under conditions of anti-androgen therapy with flutamide. Furthermore, this study describes the mechanisms of a promising therapeutic alternative for NMIBC based on Protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride (P-MAPA) intravesical immunotherapy combined with flutamide, involving the interaction among steroid hormone receptors, their regulators and Toll-like receptors (TLRs). Our results demonstrated that increased Siah-2 and AR protein levels and decreased N-CoR, cytochrome P450 (CYP450) and estrogen receptors levels played a critical role in the urothelial carcinogenesis, probably leading to escape of urothelial cancer cells from immune system attack. P-MAPA immunotherapy led to distinct activation of innate immune system TLRs 2 and 4-mediated, resulting in increase of interferon signaling pathway, which was more effective in recovering the immunosuppressive tumor immune microenvironment and in recovering the bladder histology features than BCG (Bacillus Calmette-Guerin) treatments. The AR blockade therapy was important in the modulating of downstream molecules of TLR2 and TLR4 signaling pathway, decreasing the inflammatory cytokines signaling and enhancing the interferon signaling pathway when associated with P-MAPA. Taken together, the data obtained suggest that interferon signaling pathway activation and targeting AR and Siah-2 signals by P-MAPA intravesical immunotherapy alone and/ or in combination with AR blockade may provide novel therapeutic approaches for NMIBC.

  12. Downstream of tyrosine kinase/docking protein 6, as a novel substrate of tropomyosin-related kinase C receptor, is involved in neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons

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    Yuan Jian

    2010-06-01

    Full Text Available Abstract Background The downstream of tyrosine kinase/docking protein (Dok adaptor protein family has seven members, Dok1 to Dok7, that act as substrates of multiple receptor tyrosine kinase and non-receptor tyrosine kinase. The tropomyosin-related kinase (Trk receptor family, which has three members (TrkA, TrkB and TrkC, are receptor tyrosine kinases that play pivotal roles in many stages of nervous system development, such as differentiation, migration, axon and dendrite projection and neuron patterning. Upon related neurotrophin growth factor stimulation, dimerisation and autophosphorylation of Trk receptors can occur, recruiting adaptor proteins to mediate signal transduction. Results In this report, by using yeast two-hybrid assays, glutathione S-transferase (GST precipitation assays and coimmunoprecipitation (Co-IP experiments, we demonstrate that Dok6 selectively binds to the NPQY motif of TrkC through its phosphotyrosine-binding (PTB domain in a kinase activity-dependent manner. We further confirmed their interaction by coimmunoprecipitation and colocalisation in E18.5 mouse cortex neurons, which provided more in vivo evidence. Next, we demonstrated that Dok6 is involved in neurite outgrowth in mouse cortex neurons via the RNAi method. Knockdown of Dok6 decreased neurite outgrowth in cortical neurons upon neurotrophin 3 (NT-3 stimulation. Conclusions We conclude that Dok6 interacts with the NPQY motif of the TrkC receptor through its PTB domain in a kinase activity-dependent manner, and works as a novel substrate of the TrkC receptor involved in NT-3-mediated neurite outgrowth in mouse cortex neurons.

  13. Increased toll-like receptors and p53 levels regulate apoptosis and angiogenesis in non-muscle invasive bladder cancer: mechanism of action of P-MAPA biological response modifier

    International Nuclear Information System (INIS)

    Garcia, Patrick Vianna; Seiva, Fábio Rodrigues Ferreira; Carniato, Amanda Pocol; Mello Júnior, Wilson de; Duran, Nelson; Macedo, Alda Maria; Oliveira, Alexandre Gabarra de; Romih, Rok; Nunes, Iseu da Silva; Nunes, Odilon da Silva; Fávaro, Wagner José

    2016-01-01

    The new modalities for treating patients with non-muscle invasive bladder cancer (NMIBC) for whom BCG (Bacillus Calmette-Guerin) has failed or is contraindicated are recently increasing due to the development of new drugs. Although agents like mitomycin C and BCG are routinely used, there is a need for more potent and/or less-toxic agents. In this scenario, a new perspective is represented by P-MAPA (Protein Aggregate Magnesium-Ammonium Phospholinoleate-Palmitoleate Anhydride), developed by Farmabrasilis (non-profit research network). This study detailed and characterized the mechanisms of action of P-MAPA based on activation of mediators of Toll-like Receptors (TLRs) 2 and 4 signaling pathways and p53 in regulating angiogenesis and apoptosis in an animal model of NMIBC, as well as, compared these mechanisms with BCG treatment. Our results demonstrated the activation of the immune system by BCG (MyD88-dependent pathway) resulted in increased inflammatory cytokines. However, P-MAPA intravesical immunotherapy led to distinct activation of TLRs 2 and 4-mediated innate immune system, resulting in increased interferons signaling pathway (TRIF-dependent pathway), which was more effective in the NMIBC treatment. Interferon signaling pathway activation induced by P-MAPA led to increase of iNOS protein levels, resulting in apoptosis and histopathological recovery. Additionally, P-MAPA immunotherapy increased wild-type p53 protein levels. The increased wild-type p53 protein levels were fundamental to NO-induced apoptosis and the up-regulation of BAX. Furthermore, interferon signaling pathway induction and increased p53 protein levels by P-MAPA led to important antitumor effects, not only suppressing abnormal cell proliferation, but also by preventing continuous expansion of tumor mass through suppression of angiogenesis, which was characterized by decreased VEGF and increased endostatin protein levels. Thus, P-MAPA immunotherapy could be considered an important therapeutic

  14. Increased toll-like receptors and p53 levels regulate apoptosis and angiogenesis in non-muscle invasive bladder cancer: mechanism of action of P-MAPA biological response modifier.

    Science.gov (United States)

    Garcia, Patrick Vianna; Seiva, Fábio Rodrigues Ferreira; Carniato, Amanda Pocol; de Mello Júnior, Wilson; Duran, Nelson; Macedo, Alda Maria; de Oliveira, Alexandre Gabarra; Romih, Rok; Nunes, Iseu da Silva; Nunes, Odilon da Silva; Fávaro, Wagner José

    2016-07-07

    The new modalities for treating patients with non-muscle invasive bladder cancer (NMIBC) for whom BCG (Bacillus Calmette-Guerin) has failed or is contraindicated are recently increasing due to the development of new drugs. Although agents like mitomycin C and BCG are routinely used, there is a need for more potent and/or less-toxic agents. In this scenario, a new perspective is represented by P-MAPA (Protein Aggregate Magnesium-Ammonium Phospholinoleate-Palmitoleate Anhydride), developed by Farmabrasilis (non-profit research network). This study detailed and characterized the mechanisms of action of P-MAPA based on activation of mediators of Toll-like Receptors (TLRs) 2 and 4 signaling pathways and p53 in regulating angiogenesis and apoptosis in an animal model of NMIBC, as well as, compared these mechanisms with BCG treatment. Our results demonstrated the activation of the immune system by BCG (MyD88-dependent pathway) resulted in increased inflammatory cytokines. However, P-MAPA intravesical immunotherapy led to distinct activation of TLRs 2 and 4-mediated innate immune system, resulting in increased interferons signaling pathway (TRIF-dependent pathway), which was more effective in the NMIBC treatment. Interferon signaling pathway activation induced by P-MAPA led to increase of iNOS protein levels, resulting in apoptosis and histopathological recovery. Additionally, P-MAPA immunotherapy increased wild-type p53 protein levels. The increased wild-type p53 protein levels were fundamental to NO-induced apoptosis and the up-regulation of BAX. Furthermore, interferon signaling pathway induction and increased p53 protein levels by P-MAPA led to important antitumor effects, not only suppressing abnormal cell proliferation, but also by preventing continuous expansion of tumor mass through suppression of angiogenesis, which was characterized by decreased VEGF and increased endostatin protein levels. Thus, P-MAPA immunotherapy could be considered an important therapeutic

  15. Upper Tract Urothelial Carcinomas Accompanied by Previous or Synchronous Nonmuscle-Invasive Bladder Cancer and Preoperative Hydronephrosis Might Have Worse Oncologic Outcomes After Radical Nephroureterectomy.

    Science.gov (United States)

    Liang, Chengcai; Chi, Runmin; Huang, Liqun; Wang, Jinliang; Liu, Hailong; Xu, Ding; Qian, Subo; Qian, Xiaoqiang; Qi, Jun

    2016-10-01

    The purpose of the study was to identify predictors of clinicopathologic features and oncologic outcomes in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy (RNU). The medical records of 172 patients treated with RNU from January 2001 to September 2014 were retrospectively reviewed. Logistic regression and survival analysis methodology were respectively used to evaluate predictors of clinicopathologic features and oncologic outcomes. Of the enrolled 172 patients, 80 (46.5%) had renal pelvic tumors, 67 (39%) had ureteral tumors, and the remaining 25 (14.5%) patients had multifocal tumors. Compared with patients with renal pelvic tumors, those with ureteral and multifocal tumors were more likely to have previous or synchronous nonmuscle-invasive bladder cancer (NMIBC) and severe hydronephrosis (P = .001 and P hydronephrosis independently predicted worse renal function and positive lymph node or lymphovascular invasion status (P = .001 and P = .007, respectively). Moreover, severe hydronephrosis was an independent risk factor for overall survival and cancer-specific survival in multivariate analysis (P = .025 and P = .045, respectively). Multifocality and previous or synchronous NMIBC were significantly associated with bladder-recurrence-free survival (P = .023 and P = .001, respectively). Upper tract urothelial carcinoma accompanied by previous or synchronous NMIBC and preoperative severe hydronephrosis could have worse oncologic outcomes after RNU. These common accompanied diagnoses could be valuable for guiding preoperative planning and postoperative adjuvant therapy. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Recruitment Kinetics of Tropomyosin Tpm3.1 to Actin Filament Bundles in the Cytoskeleton Is Independent of Actin Filament Kinetics.

    Science.gov (United States)

    Appaduray, Mark A; Masedunskas, Andrius; Bryce, Nicole S; Lucas, Christine A; Warren, Sean C; Timpson, Paul; Stear, Jeffrey H; Gunning, Peter W; Hardeman, Edna C

    2016-01-01

    The actin cytoskeleton is a dynamic network of filaments that is involved in virtually every cellular process. Most actin filaments in metazoa exist as a co-polymer of actin and tropomyosin (Tpm) and the function of an actin filament is primarily defined by the specific Tpm isoform associated with it. However, there is little information on the interdependence of these co-polymers during filament assembly and disassembly. We addressed this by investigating the recovery kinetics of fluorescently tagged isoform Tpm3.1 into actin filament bundles using FRAP analysis in cell culture and in vivo in rats using intracellular intravital microscopy, in the presence or absence of the actin-targeting drug jasplakinolide. The mobile fraction of Tpm3.1 is between 50% and 70% depending on whether the tag is at the C- or N-terminus and whether the analysis is in vivo or in cultured cells. We find that the continuous dynamic exchange of Tpm3.1 is not significantly impacted by jasplakinolide, unlike tagged actin. We conclude that tagged Tpm3.1 may be able to undergo exchange in actin filament bundles largely independent of the assembly and turnover of actin.

  17. Tropomyosin 2 heterozygous knockout in mice using CRISPR-Cas9 system displays the inhibition of injury-induced epithelial-mesenchymal transition, and lens opacity

    Science.gov (United States)

    Shibata, Teppei; Shibata, Shinsuke; Ishigaki, Yasuhito; Kiyokawa, Etsuko; Ikawa, Masahito; Singh, Dhirendra P.; Sasaki, Hiroshi; Kubo, Eri

    2018-01-01

    The process of epithelial–mesenchymal transition (EMT) of lens epithelial cells (LECs) after cataract surgery contributes to tissue fibrosis, wound healing and lens regeneration via a mechanism not yet fully understood. Here, we show that tropomyosin 2 (Tpm2) plays a critical role in wound healing and lens aging. Posterior capsular opacification (PCO) after lens extraction surgery was accompanied by elevated expression of Tpm2. Tpm2 heterozygous knockout mice, generated via the clustered regularly interspaced short palindromic repeat/ Cas9 (CRISPR/Cas9) system showed promoted progression of cataract with age. Further, injury-induced EMT of the mouse lens epithelium, as evaluated histologically and by the expression patterns of Tpm1 and Tpm2, was attenuated in the absence of Tpm2. In conclusion, Tpm2 may be important in maintaining lens physiology and morphology. However, Tpm2 is involved in the progression of EMT during the wound healing process of mouse LECs, suggesting that inhibition of Tpm2 may suppress PCO. PMID:29510160

  18. results

    Directory of Open Access Journals (Sweden)

    Salabura Piotr

    2017-01-01

    Full Text Available HADES experiment at GSI is the only high precision experiment probing nuclear matter in the beam energy range of a few AGeV. Pion, proton and ion beams are used to study rare dielectron and strangeness probes to diagnose properties of strongly interacting matter in this energy regime. Selected results from p + A and A + A collisions are presented and discussed.

  19. Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction.

    Science.gov (United States)

    Nadal, Laura; Garcia, Neus; Hurtado, Erica; Simó, Anna; Tomàs, Marta; Lanuza, Maria A; Santafé, Manel; Tomàs, Josep

    2016-06-23

    The development of the nervous system involves an initially exuberant production of neurons that make an excessive number of synaptic contacts. The initial overproduction of synapses promotes connectivity. Hebbian competition between axons with different activities (the least active are punished) leads to the loss of roughly half of the overproduced elements and this refines connectivity and increases specificity. The neuromuscular junction is innervated by a single axon at the end of the synapse elimination process and, because of its relative simplicity, has long been used as a model for studying the general principles of synapse development. The involvement of the presynaptic muscarinic ACh autoreceptors may allow for the direct competitive interaction between nerve endings through differential activity-dependent acetylcholine release in the synaptic cleft. Then, the most active ending may directly punish the less active ones. Our previous results indicate the existence in the weakest axons on the polyinnervated neonatal NMJ of an ACh release inhibition mechanism based on mAChR coupled to protein kinase C and voltage-dependent calcium channels. We suggest that this mechanism plays a role in the elimination of redundant neonatal synapses. Here we used confocal microscopy and quantitative morphological analysis to count the number of brightly fluorescent axons per endplate in P7, P9 and P15 transgenic B6.Cg-Tg (Thy1-YFP)16 Jrs/J mice. We investigate the involvement of individual mAChR M1-, M2- and M4-subtypes in the control of axonal elimination after the Levator auris longus muscle had been exposed to agonist and antagonist in vivo. We also analysed the role of adenosine receptor subtypes (A1 and A2A) and the tropomyosin-related kinase B receptor. The data show that postnatal axonal elimination is a regulated multireceptor mechanism that guaranteed the monoinnervation of the neuromuscular synapses. The three receptor sets considered (mAChR, AR and TrkB receptors

  20. Effectivity of intravescical thermo-chemotherapy prophylaxis for patients with high recurrence and progression risk for non-muscle invasive bladder cancer.

    Science.gov (United States)

    Gözen, Ali Serdar; Umari, Paolo; Scheitlin, Walter; Su, Fuat Ernis; Akin, Yigit; Rassweiler, Jens

    2017-06-30

    Background&Aim: High grade non-muscle invasive bladder cancer (NMIBC) is common in urological practice. Most of these cancers are or become refractory to intravesical immunotherapy and chemotherapy. Here we evaluated the efficacy of combined local bladder hyperthermia and intravesical mitomycin-C (MMC) instillation in patients with high-risk recurrent NMIBC. Between February 2014 and December 2015, 18 patients with high risk NMIBC were enrolled. Patients were treated in an outpatient basis with 6 weekly induction sessions followed by monthly maintenance sessions with intravesical MMC in local hyperthermia with bladder wall thermo-chemotherapy (BWT) system (PelvixTT system, Elmedical Ltd., Hod Hasharon, Israel). The follow-up regimen included cystoscopy after the induction cycle and thereafter with regular intervals. Time to disease recurrence was defined as time from the first intravesical treatment to endoscopic or histological documentation of a new bladder tumour. Adverse events were recorded according to CTC 4.0 (Common Toxicity Criteria) score system. Mean age was 72 (32-87) years. 10 patients had multifocal disease, 9 had CIS, 6 had recurrent disease and 2 had highly recurrent disease (> 3 recurrences in a 24 months period). 6 patients underwent previous intravesical chemotherapy with MMC. The average number of maintenance sessions per patient was 7.6. After a mean follow-up of 433 days, 15 patients (83.3%) were recurrence-free. 3 patients had tumour recurrence after a mean period of 248 days without progression. Side effects were limited to grade 1 in 2 patients and grade 2 in 1 patient. BWT seems to be feasible and safe in high grade NMIBC. More studies are needed to identify the subgroup of patients who may benefit more from this treatment.

  1. The interaction between tropomyosin-related kinase B receptors and presynaptic muscarinic receptors modulates transmitter release in adult rodent motor nerve terminals.

    Science.gov (United States)

    Garcia, Neus; Tomàs, Marta; Santafé, Manel M; Besalduch, Nuria; Lanuza, Maria A; Tomàs, Josep

    2010-12-08

    The neurotrophin brain-derived neurotrophic factor (BDNF), neurotrophin-4 (NT-4) and the receptors tropomyosin-related kinase B (trkB) and p75(NTR) are present in the nerve terminals on the neuromuscular junctions (NMJs) of the levator auris longus muscle of the adult mouse. Exogenously added BDNF or NT-4 increased evoked ACh release after 3 h. This presynaptic effect (the size of the spontaneous potentials is not affected) is specific because it is not produced by neurotrophin-3 (NT-3) and is prevented by preincubation with trkB-IgG chimera or by pharmacological block of trkB [K-252a (C₂₇H₂₁N₃O₅)] or p75(NTR) [Pep5 (C₈₆H₁₁₁N₂₅O₁₉S₂] signaling. The effect of BDNF depends on the M₁ and M₂ muscarinic acetylcholine autoreceptors (mAChRs) because it is prevented by atropine, pirenzepine and methoctramine. We found that K-252a incubation reduces ACh release (~50%) in a short time (1 h), but the p75(NTR) signaling inhibitor Pep5 does not have this effect. The specificity of the K-252a blocking effect on trkB was confirmed with the anti-trkB antibody 47/trkB, which reduces evoked ACh release, like K-252a, whereas the nonpermeant tyrosine kinase blocker K-252b does not. Neither does incubation with the fusion protein trkB-IgG (to chelate endogenous BDNF/NT-4), anti-BDNF or anti-NT-4 change ACh release. Thus, the trkB receptor normally seems to be coupled to ACh release when there is no short-term local effect of neurotrophins at the NMJ. The normal function of the mAChR mechanism is a permissive prerequisite for the trkB pathway to couple to ACh release. Reciprocally, the normal function of trkB modulates M₁- and M₂-subtype muscarinic pathways.

  2. Reduction of recurrence in non-muscle invasive bladder cancer using photodynamic diagnosis and immediate post-TUR-B chemoprophylaxis

    DEFF Research Database (Denmark)

    Risager, Malene Bøg

    2013-01-01

    (TUR-B), and one single instillation of 40 mg Mitomycin C (MMC) within 24 hours post-TUR-B were introduced at our institution by March 2008. For the study, patients were identified retrospectively using procedure codes for TUR-B and cystoscopy with biopsy and fulguration. Patients with muscle......-invasive bladder cancer were excluded. 190 consecutive patients, treated between 03-01-2008 and 28-02-2010, were included into the intervention group, while 216 patients, treated between 03-01-2006 and 29-02-2008, served as controls. Procedures and pathology results were registered. The groups were comparable...

  3. Expression of smooth muscle and non-muscle myosin heavy chain isoforms in cultured vascular smooth muscle cells

    International Nuclear Information System (INIS)

    Rovner, A.S.; Murphy, R.A.; Owens, G.K.

    1986-01-01

    Immunocytochemical studies of cultured smooth muscle cells (SMCs) have disagreed on the nature of myosin expression. This investigation was undertaken to test for the presence of heterogeneous myosin heavy chain (MHC) isoforms in cell culture as a possible explanation for these results. Previously, Rovner et al. detected two MHCs in intact smooth muscles which differed in molecular weight by ca. 4000 daltons (SM1 and SM2) using a 3-4% acrylamide gradient SDS gel system. When sub-confluent primary cultures of rat aorta SMCs were assayed by this system, SM1 and SM2 were seen, along with large amounts of a third, unique MHC, NM, which closely resembled the MHC from human platelet in size and antigenicity. Data from 35 S-methionine autoradiograms showed that the log growth phase SMC cultures were producing almost exclusively NM, but the growth arrest, post-confluent cultures synthesized increased relative amounts of the SM MHC forms and contained comparable amounts of SM1, SM2, and NM. The same patterns of MHC synthesis were seen in sub-passaged SMCs. The expression of the SM-specific forms of myosin in quiescent, post-confluent cultures parallels that of smooth muscle actin suggesting that density induced growth arrest promotes cytodifferentiation in cultured vascular SMCs

  4. Production of high quality brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) RNA from isolated populations of rat spinal cord motor neurons obtained by Laser Capture Microdissection (LCM).

    Science.gov (United States)

    Mehta, Prachi; Premkumar, Brian; Morris, Renée

    2016-08-03

    The mammalian central nervous system (CNS) is composed of multiple cellular elements, making it challenging to segregate one particular cell type to study their gene expression profile. For instance, as motor neurons represent only 5-10% of the total cell population of the spinal cord, meaningful transcriptional analysis on these neurons is almost impossible to achieve from homogenized spinal cord tissue. A major challenge faced by scientists is to obtain good quality RNA from small amounts of starting material. In this paper, we used Laser Capture Microdissection (LCM) techniques to identify and isolate spinal cord motor neurons. The present analysis revealed that perfusion with paraformaldehyde (PFA) does not alter RNA quality. RNA integrity numbers (RINs) of tissue samples from rubrospinal tract (RST)-transected, intact spinal cord or from whole spinal cord homogenate were all above 8, which indicates intact, high-quality RNA. Levels of mRNA for brain-derived neurotrophic factor (BDNF) or for its tropomyosin receptor kinase B (TrkB) were not affected by rubrospinal tract (RST) transection, a surgical procedure that deprive motor neurons from one of their main supraspinal input. The isolation of pure populations of neurons with LCM techniques allows for robust transcriptional characterization that cannot be achieved with spinal cord homogenates. Such preparations of pure population of motor neurons will provide valuable tools to advance our understanding of the molecular mechanisms underlying spinal cord injury and neuromuscular diseases. In the near future, LCM techniques might be instrumental to the success of gene therapy for these debilitating conditions. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  5. Glehnia littoralis Extract Promotes Neurogenesis in the Hippocampal Dentate Gyrus of the Adult Mouse through Increasing Expressions of Brain-Derived Neurotrophic Factor and Tropomyosin-Related Kinase B.

    Science.gov (United States)

    Park, Joon Ha; Shin, Bich Na; Ahn, Ji Hyeon; Cho, Jeong Hwi; Lee, Tae-Kyeong; Lee, Jae-Chul; Jeon, Yong Hwan; Kang, Il Jun; Yoo, Ki-Yeon; Hwang, In Koo; Lee, Choong Hyun; Noh, Yoo Hun; Kim, Sung-Su; Won, Moo-Ho; Kim, Jong Dai

    2018-03-20

    Glehnia littoralis has been used for traditional Asian medicine, which has diverse therapeutic activities. However, studies regarding neurogenic effects of G. littoralis have not yet been considered. Therefore, in this study, we examined effects of G. littoralis extract on cell proliferation, neuroblast differentiation, and the maturation of newborn neurons in the hippocampus of adult mice. A total of 39 male ICR mice (12 weeks old) were randomly assigned to vehicle-treated and 100 and 200 mg/kg G. littoralis extract-treated groups (n = 13 in each group). Vehicle and G. littoralis extract were orally administrated for 28 days. To examine neurogenic effects of G. littoralis extract, we performed immunohistochemistry for 5-bromo-2-deoxyuridine (BrdU, an indicator for cell proliferation) and doublecortin (DCX, an immature neuronal marker) and double immunofluorescence staining for BrdU and neuronal nuclear antigen (NeuN, a mature neuronal marker). In addition, we examined expressional changes of brain-derived neurotrophic factor (BDNF) and its major receptor tropomyosin-related kinase B (TrkB) using Western blotting analysis. Treatment with 200 mg/kg, not 100 mg/kg, significantly increased number of BrdU-immunoreactive ( + ) and DCX + cells (48.0 ± 3.1 and 72.0 ± 3.8 cells/section, respectively) in the subgranular zone (SGZ) of the dentate gyrus (DG) and BrdU + /NeuN + cells (17.0 ± 1.5 cells/section) in the granule cell layer as well as in the SGZ. In addition, protein levels of BDNF and TrkB (about 232% and 244% of the vehicle-treated group, respectively) were significantly increased in the DG of the mice treated with 200 mg/kg of G. littoralis extract. G. littoralis extract promots cell proliferation, neuroblast differentiation, and neuronal maturation in the hippocampal DG, and neurogenic effects might be closely related to increases of BDNF and TrkB proteins by G. littoralis extract treatment.

  6. Analysis of molecular intra-patient variation and delineation of a prognostic 12-gene signature in non-muscle invasive bladder cancer; technology transfer from microarrays to PCR

    DEFF Research Database (Denmark)

    Andersen, Lars Dyrskjøt; Reinert, Thomas; Novoradovsky, A

    2012-01-01

    . Methods: We measured the intra-patient variation of an 88-gene progression signature using 39 metachronous tumours from 17 patients. For delineation of the optimal quantitative reverse transcriptase PCR panel of markers, we used 115 tumour samples from patients in Denmark, Sweden, UK and Spain. Results...

  7. Bacillus Calmette-Guérin (BCG) Treatment Failures with Non-Muscle Invasive Bladder Cancer: A Data-Driven Definition for BCG Unresponsive Disease.

    Science.gov (United States)

    Steinberg, Ryan L; Thomas, Lewis J; Mott, Sarah L; O'Donnell, Michael A

    2016-04-27

    Objective: To create the first data-driven definition for those unlikely to benefit from further BCG treatment. Materials and Methods: The database created for the Phase 2 BCG-Interferon- α 2B (IFN) study was queried and BCG failure patients were identified ( n  = 334). Full study protocols have previously been published. Separate models were constructed for analysis of patients with any CIS (pure or concomitant) and pure papillary disease. Variables considered included age, gender, stage, grade, tumor size and focality (for papillary only), number of prior BCG courses, and prior BCG failure interval. Results: Patients with recurrent CIS within 6 months of their most recent prior BCG course (HR 2.56, p  disease within 6 months (HR 1.82, p  = 0.02), ≥2 BCG failures (HR 1.54, p  = 0.03), and multifocal disease (HR 2.05, p  disease remained disease free in 38% of cases (24-51% 95% CI) at 2 years with low rates of progression. Conclusions: Patients who fail two courses of BCG with either persistent or recurrent multifocal papillary disease within 6 months or CIS within 12 months of their prior BCG should be considered BCG unresponsive. Recurrent T1 disease respond reasonably well to another course with low progression rates but further investigation is warranted.

  8. Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Meera C. Viswanathan

    2017-09-01

    Full Text Available Striated muscle contraction is regulated by the movement of tropomyosin over the thin filament surface, which blocks or exposes myosin binding sites on actin. Findings suggest that electrostatic contacts, particularly those between K326, K328, and R147 on actin and tropomyosin, establish an energetically favorable F-actin-tropomyosin configuration, with tropomyosin positioned in a location that impedes actomyosin associations and promotes relaxation. Here, we provide data that directly support a vital role for these actin residues, termed the A-triad, in tropomyosin positioning in intact functioning muscle. By examining the effects of an A295S α-cardiac actin hypertrophic cardiomyopathy-causing mutation, over a range of increasingly complex in silico, in vitro, and in vivo Drosophila muscle models, we propose that subtle A-triad-tropomyosin perturbation can destabilize thin filament regulation, which leads to hypercontractility and triggers disease. Our efforts increase understanding of basic thin filament biology and help unravel the mechanistic basis of a complex cardiac disorder.

  9. Vanillin and 4-hydroxybenzyl alcohol promotes cell proliferation and neuroblast differentiation in the dentate gyrus of mice via the increase of brain-derived neurotrophic factor and tropomyosin-related kinase B.

    Science.gov (United States)

    Cho, Jeong-Hwi; Park, Joon Ha; Ahn, Ji Hyeon; Lee, Jae-Chul; Hwang, In Koo; Park, Seung Min; Ahn, Ji Yun; Kim, Dong Won; Cho, Jun Hwi; Kim, Jong-Dai; Kim, Young-Myeong; Won, Moo-Ho; Kang, Il-Jun

    2016-04-01

    4-Hydroxy‑3-methoxybenzaldehyde (vanillin) and 4-hydroxybenzyl alcohol (4-HBA) are well‑known phenolic compounds, which possess various therapeutic properties and are widely found in a variety of plants. In the present study, the effects of vanillin and 4‑HBA were first investigated on cell proliferation, as well as neuronal differentiation and integration of granule cells in the dentate gyrus (DG) of adolescent mice using Ki‑67, doublecortin (DCX) immunohistochemistry and 5‑bromo‑2'‑deoxyuridine (BrdU)/feminizing Locus on X 3 (NeuN) double immunofluorescence. In both the vanillin and 4‑HBA groups, the number of Ki‑67+ cells, DCX+ neuroblasts and BrdU+/NeuN+ neurons were significantly increased in the subgranular zone of the DG, as compared with the vehicle group. In addition, the levels of brain‑derived neurotrophic factor (BDNF) and tropomyosin‑related kinase B (TrkB), a BDNF receptor, were significantly increased in the DG in the vanillin and 4‑HBA groups compared with the vehicle group. These results indicated that vanillin and 4‑HBA enhanced cell proliferation, neuroblast differentiation and integration of granule cells in the DG of adolescent mice . These neurogenic effects of vanillin and 4‑HBA may be closely associated with increases in BDNF and TrkB.

  10. Prognostic Performance and Reproducibility of the 1973 and 2004/2016 World Health Organization Grading Classification Systems in Non-muscle-invasive Bladder Cancer: A European Association of Urology Non-muscle Invasive Bladder Cancer Guidelines Panel Systematic Review.

    Science.gov (United States)

    Soukup, Viktor; Čapoun, Otakar; Cohen, Daniel; Hernández, Virginia; Babjuk, Marek; Burger, Max; Compérat, Eva; Gontero, Paolo; Lam, Thomas; MacLennan, Steven; Mostafid, A Hugh; Palou, Joan; van Rhijn, Bas W G; Rouprêt, Morgan; Shariat, Shahrokh F; Sylvester, Richard; Yuan, Yuhong; Zigeuner, Richard

    2017-11-01

    Tumour grade is an important prognostic indicator in non-muscle-invasive bladder cancer (NMIBC). Histopathological classifications are limited by interobserver variability (reproducibility), which may have prognostic implications. European Association of Urology NMIBC guidelines suggest concurrent use of both 1973 and 2004/2016 World Health Organization (WHO) classifications. To compare the prognostic performance and reproducibility of the 1973 and 2004/2016 WHO grading systems for NMIBC. A systematic literature search was undertaken incorporating Medline, Embase, and the Cochrane Library. Studies were critically appraised for risk of bias (QUIPS). For prognosis, the primary outcome was progression to muscle-invasive or metastatic disease. Secondary outcomes were disease recurrence, and overall and cancer-specific survival. For reproducibility, the primary outcome was interobserver variability between pathologists. Secondary outcome was intraobserver variability (repeatability) by the same pathologist. Of 3593 articles identified, 20 were included in the prognostic review; three were eligible for the reproducibility review. Increasing tumour grade in both classifications was associated with higher disease progression and recurrence rates. Progression rates in grade 1 patients were similar to those in low-grade patients; progression rates in grade 3 patients were higher than those in high-grade patients. Survival data were limited. Reproducibility of the 2004/2016 system was marginally better than that of the 1973 system. Two studies on repeatability showed conflicting results. Most studies had a moderate to high risk of bias. Current grading classifications in NMIBC are suboptimal. The 1973 system identifies more aggressive tumours. Intra- and interobserver variability was slightly less in the 2004/2016 classification. We could not confirm that the 2004/2016 classification outperforms the 1973 classification in prediction of recurrence and progression. This article

  11. Non-muscle invasive bladder cancer risk stratification

    Directory of Open Access Journals (Sweden)

    Sumit Isharwal

    2015-01-01

    Conclusion: EORTC and CUETO risk tables are the two best-established models to predict recurrence and progression in patients with NMIBC though they tend to overestimate risk and have poor discrimination for prognostic outcomes in external validation. Future research should focus on enhancing the predictive accuracy of risk assessment tools by incorporating additional prognostic factors such as depth of lamina propria invasion and molecular biomarkers after rigorous validation in multi-institutional cohorts.

  12. Proteomics of a new esophageal cancer cell line established from Persian patient.

    Science.gov (United States)

    Moghanibashi, Mehdi; Jazii, Ferdous Rastgar; Soheili, Zahra-Soheila; Zare, Maryam; Karkhane, Aliasghar; Parivar, Kazem; Mohamadynejad, Parisa

    2012-05-25

    Although the highest incidence of esophageal squamous cell carcinoma (ESCC) has repeatedly been reported from Persia (Iran), nevertheless the so far proteomic published reports were limited to one study on tissue specimens. Here we report the proteome of a newly established cell line from Persian ESCC patients and compare it with the normal primary cell proteome. Among polypeptides, whose expression was different in cell line sixteen polypeptides were identified by MALDI/TOF/TOF spectrometry. S100-A8 protein, annexin A1, annexin A2, regulatory subunit of calpain, subunit alpha type-3 of proteasome and glutamate dehydrogenase 1 were proteins down-regulated in cell line while peroxiredoxin-5, non-muscle myosin light polypeptide 6, keratin 1, annexin A4, keratin 8, tropomyosin 3, stress-induced-phosphoprotein 1 and albumin were found to be subject of up-regulation in cell line compared to the primary normal cells. The proteomic results were further verified by western blotting and RT-PCR on annexin A1 and keratin 8. In addition, among the aforementioned proteins, glutamate dehydrogenase 1, regulatory subunit of calpain, subunit alpha of type-3 proteasome and annexin A4 are proteins whose deregulation in ESCC is reported for the first time by this study. Copyright © 2012 Elsevier B.V. All rights reserved.

  13. 1998 results

    International Nuclear Information System (INIS)

    Gadonneix, P.

    1998-01-01

    This document presents the financial and commercial results of Gaz de France (GdF) company for 1998. The following points are presented successively: financial results (budget results, turnover, self-financing capacity, investments, debt situation), commercial results (some remarkable numbers and records, the tertiary and residential market, the industrial market, cogeneration and natural gas for vehicles), the strategy, 1998 realizations and perspectives (the natural gas energy in the 21. century, the development of GdF, the gas distribution and services (development of the French distribution system, export of the know-how, development of services), the transportation and storage systems threw Europe (densification of the pipeline network, the key-position of France, the north-south equilibrium of the distribution network), the natural gas production by GdF, the diversification of supplies, and the main daughter companies abroad). (J.S.)

  14. Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS.

    Directory of Open Access Journals (Sweden)

    Jennifer A Watson

    2015-06-01

    Full Text Available Neurons are particularly vulnerable to perturbations in endo-lysosomal transport, as several neurological disorders are caused by a primary deficit in this pathway. In this report, we used positional cloning to show that the spontaneously occurring neurological mutation teetering (tn is a single nucleotide substitution in hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs/Hrs, a component of the endosomal sorting complex required for transport (ESCRT. The tn mice exhibit hypokenesis, muscle weakness, reduced muscle size and early perinatal lethality by 5-weeks of age. Although HGS has been suggested to be essential for the sorting of ubiquitinated membrane proteins to the lysosome, there were no alterations in receptor tyrosine kinase levels in the central nervous system, and only a modest decrease in tropomyosin receptor kinase B (TrkB in the sciatic nerves of the tn mice. Instead, loss of HGS resulted in structural alterations at the neuromuscular junction (NMJ, including swellings and ultra-terminal sprouting at motor axon terminals and an increase in the number of endosomes and multivesicular bodies. These structural changes were accompanied by a reduction in spontaneous and evoked release of acetylcholine, indicating a deficit in neurotransmitter release at the NMJ. These deficits in synaptic transmission were associated with elevated levels of ubiquitinated proteins in the synaptosome fraction. In addition to the deficits in neuronal function, mutation of Hgs resulted in both hypermyelinated and dysmyelinated axons in the tn mice, which supports a growing body of evidence that ESCRTs are required for proper myelination of peripheral nerves. Our results indicate that HGS has multiple roles in the nervous system and demonstrate a previously unanticipated requirement for ESCRTs in the maintenance of synaptic transmission.

  15. Extraordinary results

    International Nuclear Information System (INIS)

    Cicova, V.

    2012-01-01

    For the first time in the history, Slovenske elektrarne became the first winner in a new category Business and Biodiversity in the competition of European companies aimed at the environment protection. Excellent results were achieved by a long-term co-operation with the Tatras National Park, in particular in saving the endangered animals.

  16. Ganil results

    International Nuclear Information System (INIS)

    Tamain, B.

    1992-06-01

    Recent Ganil results are presented: hot nuclei properties and multifragmentation, study of flow change around the inversion energy. Mesons and hard photons production are also briefly discussed. Correlations with studies that have been led in Saturne energy range, and the developments that can be foreseen in the future have been discussed

  17. SAGE results

    International Nuclear Information System (INIS)

    Gavrin, V.N.

    1996-01-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) is described. The solar neutrino flux measured by 31 extractions through October, 1993 is presented. The result of 69+/-10(stat)+5/-7(syst) SNU is to be compared with a Standard Solar Model prediction of 132 SNU. The initial results of a measurement of experimental efficiencies are also discussed by exposing the gallium target to neutrinos from an artificial source. The capture rate of neutrinos from this source is very close to that which is expected. The result can be expressed as a ratio of the measured capture rate to the anticipated rate from the source activity. This ratio is 0.93+0.15, -0.17 where the systematic and statistical errors have been combined. To first order the experimental efficiencies are in agreement with those determined during solar neutrino measurements and in previous auxiliary measurements. One must conclude that the discrepancy between the measured solar neutrino flux and that predicted by the solar models can not arise from an experimental artifact. (author)

  18. Divergent regulation of the sarcomere and the cytoskeleton.

    Science.gov (United States)

    Schevzov, Galina; Fath, Thomas; Vrhovski, Bernadette; Vlahovich, Nicole; Rajan, Sudarsan; Hook, Jeff; Joya, Josephine E; Lemckert, Frances; Puttur, Franz; Lin, Jim J-C; Hardeman, Edna C; Wieczorek, David F; O'Neill, Geraldine M; Gunning, Peter W

    2008-01-04

    The existence of a feedback mechanism regulating the precise amounts of muscle structural proteins, such as actin and the actin-associated protein tropomyosin (Tm), in the sarcomeres of striated muscles is well established. However, the regulation of nonmuscle or cytoskeletal actin and Tms in nonmuscle cell structures has not been elucidated. Unlike the thin filaments of striated muscles, the actin cytoskeleton in nonmuscle cells is intrinsically dynamic. Given the differing requirements for the structural integrity of the actin thin filaments of the sarcomere compared with the requirement for dynamicity of the actin cytoskeleton in nonmuscle cells, we postulated that different regulatory mechanisms govern the expression of sarcomeric versus cytoskeletal Tms, as key regulators of the properties of the actin cytoskeleton. Comprehensive analyses of tissues from transgenic and knock-out mouse lines that overexpress the cytoskeletal Tms, Tm3 and Tm5NM1, and a comparison with sarcomeric Tms provide evidence for this. Moreover, we show that overexpression of a cytoskeletal Tm drives the amount of filamentous actin.

  19. Clinical impact of bladder biopsies with TUR-BT according to cytology results in patients with bladder cancer: a case control study

    Directory of Open Access Journals (Sweden)

    Matsumoto Kazuhiro

    2010-06-01

    Full Text Available Abstract Background There seems to be no consensus concerning taking bladder biopsies during transurethral resection of bladder tumor (TUR-BT. We investigate the clinical significance of bladder biopsy with TUR-BT and the relationship between urinary cytology and the biopsy results. Methods We reviewed a total of 424 patients with non-muscle invasive bladder cancer treated with TUR-BT between 1998 and 2005. Of the total, 293 patients also underwent a bladder biopsy. Biopsies from suspicious-appearing urothelium (N = 59 and those from normal-appearing urothelium (N = 234 were evaluated separately. Results Bladder cancer was observed in 23 cases (39.0% who underwent a biopsy of suspicious-appearing urothelium. Among these 23 cases, 9 cases with visible tumor resection had carcinoma in situ (CIS only in the biopsies from suspicious-appearing urothelium. Urinary cytology was negative in 3 of the 9 cases. Bladder cancer was observed in 26 cases (11.1% who underwent a biopsy of normal-appearing urothelium. Of them, 5 cases with visible tumors had CIS only in the multiple biopsies from normal-appearing urothelium. Urinary cytology was positive in all of the 5 cases. No upstaging or upgrading cases were found in these patients by the addition of these two types of biopsy. Furthermore, therapy was not altered in these patients. With or without bladder biopsy was not a significant factor for tumor recurrence in either the univariate or multivariate analysis. Conclusions Based on the results, it is concluded the multiple biopsies from normal-appearing urothelium are not necessary in patients with negative cytology results because of the low detection rate and lack of influence on therapeutic decisions. Meanwhile, biopsy of suspicious-appearing urothelium is needed in patients with negative cytology results in order to detect CIS due to staging properties. This result supports a recent EAU guideline.

  20. OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency.

    Science.gov (United States)

    Ullrich, M; Weber, M; Post, A M; Popp, S; Grein, J; Zechner, M; Guerrero González, H; Kreis, A; Schmitt, A G; Üçeyler, N; Lesch, K-P; Schuh, K

    2018-02-01

    Obsessive-compulsive disorder (OCD) is a common neuropsychiatric disease affecting about 2% of the general population. It is characterized by persistent intrusive thoughts and repetitive ritualized behaviors. While gene variations, malfunction of cortico-striato-thalamo-cortical (CSTC) circuits, and dysregulated synaptic transmission have been implicated in the pathogenesis of OCD, the underlying mechanisms remain largely unknown. Here we show that OCD-like behavior in mice is caused by deficiency of SPRED2, a protein expressed in various brain regions and a potent inhibitor of Ras/ERK-MAPK signaling. Excessive self-grooming, reflecting OCD-like behavior in rodents, resulted in facial skin lesions in SPRED2 knockout (KO) mice. This was alleviated by treatment with the selective serotonin reuptake inhibitor fluoxetine. In addition to the previously suggested involvement of cortico-striatal circuits, electrophysiological measurements revealed altered transmission at thalamo-amygdala synapses and morphological differences in lateral amygdala neurons of SPRED2 KO mice. Changes in synaptic function were accompanied by dysregulated expression of various pre- and postsynaptic proteins in the amygdala. This was a result of altered gene transcription and triggered upstream by upregulated tropomyosin receptor kinase B (TrkB)/ERK-MAPK signaling in the amygdala of SPRED2 KO mice. Pathway overactivation was mediated by increased activity of TrkB, Ras, and ERK as a specific result of SPRED2 deficiency and not elicited by elevated brain-derived neurotrophic factor levels. Using the MEK inhibitor selumetinib, we suppressed TrkB/ERK-MAPK pathway activity in vivo and reduced OCD-like grooming in SPRED2 KO mice. Altogether, this study identifies SPRED2 as a promising new regulator, TrkB/ERK-MAPK signaling as a novel mediating mechanism, and thalamo-amygdala synapses as critical circuitry involved in the pathogenesis of OCD.

  1. The Occurrence of Sequences Identical with Epitopes from the Allergen Pen a 1.0102 Among Food and Non-Food Proteins

    Directory of Open Access Journals (Sweden)

    Minkiewicz Piotr

    2015-03-01

    Full Text Available The presence of common epitopes among tropomyosins of invertebrates, including arthropods, e.g. edible ones, may help to explain the molecular basis of cross-reactivity between allergens. The work presented is the first survey concerning global distribution of epitopes from Pen a 1.0102 in universal proteome. In the group of known tropomyosin epitopes, the fragment with the sequence ESKIVELEEEL was found in the sequence of channel catfish (Ictalurus punctatus tropomyosin. To date, this is the first result suggesting the presence of a complete sequential epitope interacting with gE in vertebrate tropomyosin. Another fragment with the sequence VAALNRRIQL, a major part of the epitope, was found in 11 fish, 8 amphibians, 3 birds, 19 mammalians and 4 human tropomyosin sequences. Identical epitopes are common in sequences of invertebrate tropomyosins, including food and non-food allergens annotated in the Allergome database. The rare pentapeptide with the DEERM sequence occurs in proteins not sharing homology with tropomyosins. Pathogenic microorganisms are the most abundant category of organisms synthesizing such proteins.

  2. Identification of a cross-reactive allergen (presumably tropomyosin) in shrimp, mite and insects

    NARCIS (Netherlands)

    Witteman, A. M.; Akkerdaas, J. H.; van Leeuwen, J.; van der Zee, J. S.; Aalberse, R. C.

    1994-01-01

    A monoclonal antibody to Dermatophagoides pteronyssinus is described that cross-reacts with an IgE-binding antigen present in insects, Crustacea (e.g. shrimp) and other invertebrates. By means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis, gel filtration and immunofluorescence it was

  3. Muscarinic, adenosine and tropomyosin-related kinase B receptors modulate the neuromuscular developmental synapse elimination process

    OpenAIRE

    Nadal Magriñà, Laura

    2017-01-01

    El desarrollo del sistema nervioso periférico implica una inicial exuberante producción de neuronas y, una posterior reducción dependiente de actividad del número de sinapsis en las uniones neuromusculares (NMJ). Este proceso se denomina eliminación sináptica. Al final de la segunda semana postnatal, cada fibra muscular esta inervadas por una solo motoneurona. Los receptores muscarínicos de acetilcolina (mAChR), los receptores de adenosina (AR) y el receptor quinasa de tropomiosina B (TrkB) p...

  4. Adjuvant intravesical treatment for nonmuscle invasive bladder cancer: The importance of the strain and maintenance.

    Science.gov (United States)

    Guerrero-Ramos, F; Lara-Isla, A; Justo-Quintas, J; Duarte-Ojeda, J M; de la Rosa-Kehrmann, F; Villacampa-Aubá, F

    2017-11-01

    Intravesical Bacille Calmette-Guérin (BCG) is essential for preventing the recurrence and progression of superficial bladder tumours. The aim of our study was to compare the efficacy and toxicity of the Connaught and Tice strains, as well as the importance of the maintenance regimen. We retrospectively reviewed 110 patients with superficial bladder tumours who underwent adjuvant endovesical treatment. The patients were distributed into 3 groups, based on whether the treatment was with the Connaught strain, the Tice strain or both sequentially. We calculated the relapse-free survival rate in each group and compared the patients who completed the maintenance treatments against those who did not. To identify the predictors of relapse, we performed a multivariate analysis. We also assessed the toxicity by analysing the onset of BCGitis, urinary urgency, fever, urinary tract infection and treatment withdrawing due to adverse effects. We found no differences in the efficacy parameters. The patients in the Connaught group completed the maintenance to a lesser extent (38.4 vs. 72% for the Tice group and 76.3% for both groups; P=.010). The patients who completed the maintenance had better relapse-free survival at 60 months (88.5 vs. 74.2%; P=.036), regardless of the strain employed. The multivariate analysis identified a size larger than 3cm, more than 3 implants and not completing the maintenance as risk factors of relapse. The patients with the Connaught strain had higher rates of BCGitis, with no differences in the other events studied. Completing the maintenance phase is essential, regardless of the strain employed. The Connaught strain has a greater risk of BCGitis, and a sequential regimen could be useful in certain scenarios. Copyright © 2017 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

  5. Evaluation of tissue and urinary survivin expression in non-muscle ...

    African Journals Online (AJOL)

    However, they suffer from drawbacks where cystoscopy is an invasive procedure and urine cytology shows limited ability to detect low grade bladder tumors. Therefore, new non-invasive tests with high sensitivity and specificity that are easy to perform are needed not only for initial diagnosis but also in surveillance for ...

  6. Recombinant Mycobacterium bovis BCG for immunotherapy in nonmuscle invasive bladder cancer.

    Science.gov (United States)

    Begnini, K R; Buss, J H; Collares, T; Seixas, F K

    2015-05-01

    In the past three decades, intravesical instillation of Mycobacterium bovis bacille Calmette-Guérin (BCG) has been used for treating bladder cancer and it still remains at the forefront of immunotherapy for cancer patients. Although BCG-based therapy is the most effective intravesical therapy for this kind of tumor and represents the only agent known to reduce progression into muscle invasive bladder cancer, BCG is ineffective in approximately 30-40 % of cases and disease recurs in up to 50 % of patients. Since that BCG is considered an effective vehicle for delivery of antigens due to its unique characteristics, the genetic manipulation of these mycobacteria has been appealing in the search for less toxic and more potent therapeutic agents for bladder cancer immunotherapy. Herein, we discuss current advances in recombinant BCG construction, research, concerns, and future directions to promote the development of this promising immunotherapeutic approach for bladder cancer.

  7. Total 2004 results

    International Nuclear Information System (INIS)

    2005-02-01

    This document presents the 2004 results of Total Group: consolidated account, special items, number of shares, market environment, adjustment for amortization of Sanofi-Aventis merger-related intangibles, 4. quarter 2004 results (operating and net incomes, cash flow), upstream (results, production, reserves, recent highlights), downstream (results, refinery throughput, recent highlights), chemicals (results, recent highlights), Total's full year 2004 results (operating and net income, cash flow), 2005 sensitivities, Total SA parent company accounts and proposed dividend, adoption of IFRS accounting, summary and outlook, main operating information by segment for the 4. quarter and full year 2004: upstream (combined liquids and gas production by region, liquids production by region, gas production by region), downstream (refined product sales by region, chemicals), Total financial statements: consolidated statement of income, consolidated balance sheet (assets, liabilities and shareholder's equity), consolidated statements of cash flows, business segments information. (J.S.)

  8. Total 2004 results

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-02-01

    This document presents the 2004 results of Total Group: consolidated account, special items, number of shares, market environment, adjustment for amortization of Sanofi-Aventis merger-related intangibles, 4. quarter 2004 results (operating and net incomes, cash flow), upstream (results, production, reserves, recent highlights), downstream (results, refinery throughput, recent highlights), chemicals (results, recent highlights), Total's full year 2004 results (operating and net income, cash flow), 2005 sensitivities, Total SA parent company accounts and proposed dividend, adoption of IFRS accounting, summary and outlook, main operating information by segment for the 4. quarter and full year 2004: upstream (combined liquids and gas production by region, liquids production by region, gas production by region), downstream (refined product sales by region, chemicals), Total financial statements: consolidated statement of income, consolidated balance sheet (assets, liabilities and shareholder's equity), consolidated statements of cash flows, business segments information. (J.S.)

  9. Recent results from TASSO

    International Nuclear Information System (INIS)

    Foster, B.

    1982-03-01

    Results are presented on the inclusive production of π 0 , K 0 and antiK 0 and lambda and antilambda in e + e - annihilation. These results, together with those on inclusive charged hadron production are used to obtain information on fragmentation mechanisms and the production of heavy quark flavours in e + e - annihilation. (author)

  10. Recent results from TRISTAN

    Energy Technology Data Exchange (ETDEWEB)

    Enomoto, Ryoji [National Laboratory for High Energy Physics, Ibaraki (Japan)

    1997-01-01

    TRISTAN results on {gamma}{gamma} physics from 1994 to 1995 are reviewed in this report. We have systematically investigated jet production, the {gamma}-structure function, and charm pair production in {gamma}{gamma} processes. The results are discussed, and future prospects are presented.

  11. Annual results 2004

    International Nuclear Information System (INIS)

    2005-01-01

    This 2004 annual evaluation of the french RTE company (electric power transport network) provides information on the 2004 results on: institutional information, financial results, customers and market, industrial resources, environment and consultation, human resources and international aspects. (A.L.B.)

  12. Tevatron physics results

    CERN Multimedia

    CERN. Geneva

    2007-01-01

    I will summarize the physics results from the Tevatron experiments with particular emphasis on the experimental methods used in different kinds of analysis. In particular, the Tevatron is a proton-antiproton collider that has now accumulated more than 2 fb^-1 of luminosity in the two experiments, called CDF and D0. In this lecture I will review the results on inclusive productions of jets, W- and Z-bosons, the results in the flavor sector, the measurements of top production, searches for Higgs boson production and searches for physics beyond the Standard Model. In each case I will explain the basic experimental concepts and methods needed for making the measurement.

  13. CMS Higgs boson results

    CERN Document Server

    Bluj, Michal Jacek

    2018-01-01

    In this report we review recent Higgs boson results obtained with pp collisions at $\\sqrt{s}=\\,$13 TeV recorded by the CMS detector in 2016 for an integrated luminosity of 35.9fb$^{\\text{-1}}$. The 2016 data allowed the observation of the $H \\to \\tau\\tau$ and $H \\to WW$ decays with high significance. We also present a combined measurement based on a full set of CMS analyses performed with 2016 data. These results are compatible with the standard model predictions with precision of several measurements exceeding results from combination of ATLAS and CMS data collected in 2011 and 2012.

  14. Arsenic speciation results

    Data.gov (United States)

    U.S. Environmental Protection Agency — Linear combination fitting results of synchrotron data to determine arsenic speciation in soil samples. This dataset is associated with the following publication:...

  15. Haiti DevResults

    Data.gov (United States)

    US Agency for International Development — DevResults is a web-based portfolio management system that tracks program data for the Haiti Mission that was awarded in April of 2013. (The Mozambique and/or...

  16. ATLAS soft QCD results

    CERN Document Server

    Sykora, Tomas; The ATLAS collaboration

    2018-01-01

    Recent results of soft QCD measurements performed by the ATLAS collaboration are reported. The measurements include total, elastic and inelastic cross sections, inclusive spectra, underlying event and particle correlations in p-p and p-Pb collisions.

  17. Atmospheric Deposition Modeling Results

    Data.gov (United States)

    U.S. Environmental Protection Agency — This asset provides data on model results for dry and total deposition of sulfur, nitrogen and base cation species. Components include deposition velocities, dry...

  18. Transacsys PLC - Final Results

    CERN Multimedia

    2002-01-01

    Final results from Transacsys PLC. A subsidary of this company was set up to develop the CERN EDH system into a commercial product but incurred too much financial loss so the project was cancelled (1/2 page).

  19. New particles: experimental results

    International Nuclear Information System (INIS)

    Augustin, J.E.

    The results of studies on production and properties of psi(3100) and psi(3700) resonances are presented, particular attention being given to spin, parity, g-parity and isospin determination. Evidence obtained in the SPEAR and DORIS storage rings in psi'→γ chi and psi→γX intermediate states are presented, together with SPEAR results on e-μ events and high energy jet production. (39 references) [fr

  20. Antares: preliminary demonstrator results

    International Nuclear Information System (INIS)

    Kouchner, A.

    2000-05-01

    The ANTARES collaboration is building an undersea neutrino telescope off Toulon (Mediterranean sea) with effective area ∼ 0.1 km 2 . An extensive study of the site properties has been achieved together with software analysis in order to optimize the performance of the detector. Results are summarized here. An instrumented line, linked to shore for first time via an electro-optical cable, has been immersed late 1999. The preliminary results of this demonstrator line are reported. (author)

  1. Chapter 5: Monitoring results

    DEFF Research Database (Denmark)

    Poel, Bart; Thomsen, Kirsten Engelund; Schultz, Jørgen Munthe

    2003-01-01

    The monitoring results from the IEA Task 13 project "Advanced solar low energy houses" are described in this chapter. The underlying information was collected in the form of questionnaires. The questionnaires were formulated in such a way that participants are provided with a uniform lay......-out to fill in their particular results. Thus it is possible to compare the performances measured, calculated or predicted for the different houses....

  2. Compilation of results 1987

    International Nuclear Information System (INIS)

    1987-01-01

    A compilation is carried out which in concentrated form presents reports on research and development within the nuclear energy field covering a two and a half years period. The foregoing report was edited in December 1984. The projects are presendted with title, project number, responsible unit, person to contact and short result reports. The result reports consist of short summaries over each project. (L.F.)

  3. Higgs results from ATLAS

    International Nuclear Information System (INIS)

    Chen, Xin

    2016-01-01

    The updated Higgs measurements in various search channels with ATLAS Run 1 data are reviewed. Both the Standard Model (SM) Higgs results, such as H → γγ, ZZ, WW, ττ, μμ, bb-bar, and Beyond Standard Model (BSM) results, such as the charged Higgs, Higgs invisible decay and tensor couplings, are summarized. Prospects for future Higgs searches are briefly discussed

  4. Unfavorable results in replantation

    Directory of Open Access Journals (Sweden)

    Abraham G Thomas

    2013-01-01

    Full Text Available Reattachment of amputated parts of the body (Replantation has become a reality since the first arm replant was carried out six decades ago. Failures were not uncommon in the beginning, leading on to the analysis of the problem and refinements in technique. Improvements in sutures, instrumentation and better microscopes further helped the surgeons to do replantation with better finesse and functional results. Evaluation of results and particularly failure and long term results help the younger surgeons to learn from the difficulties faced earlier to do better in the future. An attempt is made to list various aspects of replantation experienced by the author during the past 30 years, particularly in reference to unfavorable results, which had been occasionally total failure, or a partial failure, with poor function and cosmesis due to infection. An insensate limb with poor function is the result of inadequate or improper nerve coaptation or infection destroying the whole repair. It is apt to mention that infection is mostly the result of poor vascularity due to devitalized tissue. Difficulties arise often in identifying the viable tissue, particularly while debriding in the distal amputated part since there is no bleeding. Experience counts in this, specifically to identify the viable muscle. The factors that may lead to complications are listed with remarks to avoid them.

  5. Total 2003 Results

    International Nuclear Information System (INIS)

    2003-01-01

    This document presents the 2003 results of Total Group: consolidated account, special items, number of shares, market environment, 4. quarter 2003 results, full year 2003 results, upstream (key figures, proved reserves), downstream key figures, chemicals key figures, parent company accounts and proposed dividends, 2004 sensitivities, summary and outlook, operating information by segment for the 4. quarter and full year 2003: upstream (combined liquids and gas production by region, liquids production by region, gas production by region), downstream (refinery throughput by region, refined product sales by region, chemicals), impact of allocating contribution of Cepsa to net operating income by business segment: equity in income (loss) and affiliates and other items, Total financial statements: consolidated statement of income, consolidated balance sheet (assets, liabilities and shareholder's equity), consolidated statements of cash flows, business segments information. (J.S.)

  6. Results from EQAS 2002

    DEFF Research Database (Denmark)

    Petersen, A.; Aarestrup, Frank Møller; Jensen, A.B.

    An international external quality assurance program on serotyping and antimicrobial susceptibility testing of eight Salmonella enterica strains was performed to enhance the capacity of national and regional reference laboratories in WHO Global Salm-Surv (WHO GSS). In 2002 a total of 117 laborator......An international external quality assurance program on serotyping and antimicrobial susceptibility testing of eight Salmonella enterica strains was performed to enhance the capacity of national and regional reference laboratories in WHO Global Salm-Surv (WHO GSS). In 2002 a total of 117...... laboratories from 67 countries participated. For serotyping, almost 90 % of the results were correct. For susceptibility testing, 91 % of the results were in agreement with the expected results, and 86 % of the performed tests with the reference strain E. coli ATCC 25922 were inside the quality control range...

  7. RTE - 2012 financial results

    International Nuclear Information System (INIS)

    Ricour, Olivia; Marguier, Marina; Lartigau, Thierry

    2013-01-01

    The mission of RTE, the French electricity Transportation grid, a public service assignment, is to balance the electricity supply and demand in real time. This report presents RTE's financial results for 2012: increase of investments for services to clients, performance results, financial balance, stability of the economical model. RTE's regulated economical model, main financial indicators, 2007-2012 investments, 2012 investments by category, 2012 turnover, 2012 costs structure, taxes, financial balance sheet at the end of 2012, and the share of electricity transport in the electricity price are presented in appendixes

  8. Geochemical investigations and results

    International Nuclear Information System (INIS)

    Herbert, H.J.; Sander, W.

    1986-01-01

    The following information can be derived from results so far for a final store: - With known mineralogy, precise information can be given on the solution metamorphosis processes to be expected. The previous results of this in-situ experiment have confirmed the theoretical considerations. - Sensors were developed and tested, which make possible continuous monitoring under hydrostatic pressure in a final store in the case of incoming solution, i.e. for exploration bores. - The collection of physical and chemical parameters in open sections and shafts creates the basis for assessing the effect of backfilling from the chemical point of view. (orig./PW) [de

  9. Results from SAGE II

    International Nuclear Information System (INIS)

    Nico, J.S.

    1994-01-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first nine runs of SAGE II give a capture rate of 66 -13 +18 (stat) -7 +5 (sys) SNU. Combined with the SAGE I result of 73 -16 +18 (stat) -7 5 (sys) SNU, the capture rate is 69 -11 +11 (stat) -7 +5 (sys) SNU. This represents only 52%--56% of the capture rate predicted by different Standard Solar Models

  10. First AFP results

    CERN Document Server

    Staszewski, Rafal; The ATLAS collaboration

    2017-01-01

    ATLAS Forward Proton (AFP) are detectors dedicated to measurements of protons scattered diffractively or electromagnetically at small angles in inelastic processes. The first arm of AFP was installed in 2016. The installation of the full system was finished in 2017. Since 2016 AFP has collected data is special and standard runs. The presentation shows the first results obtained with data collected by AFP.

  11. Recent results of BABAR

    International Nuclear Information System (INIS)

    Bernard, D.

    2001-01-01

    The BABAR detector at SLAC's PEP-II storage ring has collected data amounting to about 30.4 fb -1 until june 2001. Results on CP violation, and in particular search for direct CP violation, and measurement of rare B decays are presented

  12. Roadmap of Infinite Results

    DEFF Research Database (Denmark)

    Srba, Jiří

    2002-01-01

    This paper provides a comprehensive summary of equivalence checking results for infinite-state systems. References to the relevant papers will be updated continuously according to the development in the area. The most recent version of this document is available from the web-page http://www.brics.dk/~srba/roadmap....

  13. IRU Results and Perspectives

    NARCIS (Netherlands)

    Bronswijk, van J.E.M.H.

    2003-01-01

    This chapter is devoted to the disciplines within USOBuilt Graduate School as organized in International Research and Design Units, the fora where research and design at a (post)doctorate level is performed and taught. A fixed template was used to self-assess results and perspectives, consisting of

  14. Results of CPLEAR

    International Nuclear Information System (INIS)

    Rickenbach, R.; Adler, R.; Alhalel, T.; Angelopoulos, A.; Apostolakis, A.; Aslanides, E.; Backenstoss, G.; Bargassa, P.; Bee, C.P.; Behnke, O.; Benelli, A.; Bertin, V.; Blanc, F.; Bloch, P.; Carlson, P.; Carroll, M.; Carvalho, J.; Cawley, E.; Charalambous, S.; Chardin, G.; Chertok, M.B.; Cody, A.; Danielsson, M.; Dejardin, M.; Derre, J.; Ealet, A.; Eckart, B.; Eleftheriadis, C.; Evangelou, I.; Faravel, L.; Fassnacht, P.; Felder, C.; Ferreira-Marques, R.; Fetscher, W.; Fidecaro, M.; Filipcic, A.; Francis, D.; Fry, J.; Gabathuler, E.; Gamet, R.; Garreta, D.; Gerber, H.-J.; Go, A.; Guyot, C.; Haselden, A.; Hayman, P.J.; Henry-Couannier, F.; Hollander, R.W.; Hubert, E.; Jon-And, K.; Kettle, P.-R.; Kochowski, C.; Kokkas, P.; Kreuger, R.; Le Gac, R.; Leimgruber, F.; Liolios, A.; Machado, E.; Mandic, I.; Manthos, N.; Marel, G.; Mikuz, M.; Miller, J.; Montanet, F.; Nakada, T.; Pagels, B.; Papadopoulos, I.; Pavlopoulos, P.; Pinto da Cunha, J.; Policarpo, A.; Polivka, G.; Roberts, B.L.; Ruf, T.; Sakeliou, L.; Sanders, P.; Santoni, C.; Schaefer, M.; Schaller, L.A.; Schietinger, T.; Schopper, A.; Schune, P.; Soares, A.; Tauscher, L.; Thibault, C.; Touchard, F.; Touramanis, C.; Triantis, F.; Van Beveren, E.; Van Eijk, C.W.E.; Vlachos, S.; Weber, P.; Wigger, O.; Wolter, M.; Yeche, C.; Zavrtanik, D.; Zimmerman, D.

    1997-01-01

    The CPLEAR experiment uses tagged K 0 and K 0 produced in pp annihilation at rest to measure CP-, T- and CPT-violation parameters in the neutral kaon system. The results of these measurements and some implications are reported. (orig.)

  15. Same query - different results

    International Nuclear Information System (INIS)

    Nevyjel, A.

    1983-10-01

    On behalf of a case study a simple truncated adjacency phrase search was executed in the online versions of Chemical Abstracts on five different host computers (DATA-STAR, DIALOG, ESA, SDC, TELESYSTEMES). The reasons for the differences in the appearing results are discussed. (Author) [de

  16. Management Values Survey Results.

    Science.gov (United States)

    Duffy, Barbara; Payne, Ron

    1988-01-01

    Describes results of a survey conducted to compare values of members of the Association for Educational Communications and Technology (AECT) with managers in business and industry. Issues discussed include job satisfaction, opportunities for advancement, attitudes toward management, and salary; a summary of each value system is provided. (LRW)

  17. Plan Merging : Experimental results

    NARCIS (Netherlands)

    De Weerdt, M.M.; Van der Krogt, R.P.J.; Zutt, J.

    2003-01-01

    In this paper we discuss the results of a plan merging algorithm. This algorithm coordinates the plans of multiple, autonomous agents, each able to independently find a plan. This algorithm is evaluated using realistic data from a taxi company. We show that when we allow passengers to be a few

  18. First results at GSI

    International Nuclear Information System (INIS)

    Bock, R.

    1977-01-01

    UNILAC, and accelerator for heavy ions up to uranium with energies up to 10 MeV/nucleon became operational January 1976. A report is given on results so far in various fields of heavy ion physics, in particular on search for new nuclides, deep-inelastic collisions, spectroscopy of high-spin states and some selected topics of atomic physics. (orig.) [de

  19. Communicating research results

    Science.gov (United States)

    Jan Fryk

    1999-01-01

    A research finding is of little value until it is known and applied. Hence) communication of results should be regarded as a natural, integrated part of research) and thus addressed in the research plans from the very beginning. A clearly defined information strategy and operational goals for information activities are needed for successful communication. For maximum...

  20. Review of LEP results

    CERN Document Server

    Parodi, F

    2001-01-01

    I present a review of the results obtained during 10 years of activity in b-physics at LEP. Special emphasis is put on measurements that attained precisions not even envisaged at the beginning of the LEP programme (V/sub ub/ and Delta m/sub s/). Finally the impact of these measurements on the CKM parameters determination is presented. (16 refs).

  1. [The applicability of results].

    Science.gov (United States)

    Marín-León, I

    2015-11-01

    The ultimate aim of the critical reading of medical literature is to use the scientific advances in clinical practice or for innovation. This requires an evaluation of the applicability of the results of the studies that have been published, which begins with a clear understanding of these results. When the studies do not provide sufficient guarantees of rigor in design and analysis, the conditions necessary for the applicability of the results are not met; however, the fact that the results are reliable is not enough to make it worth trying to use their conclusions. This article explains how carrying out studies in experimental or artificial conditions often moves them away from the real conditions in which they claim to apply their conclusions. To evaluate this applicability, the article proposes evaluating a set of items that will enable the reader to determine the likelihood that the benefits and risks reported in the studies will yield the least uncertainty in the clinical arena where they aim to be applied. Copyright © 2015 SERAM. Published by Elsevier España, S.L.U. All rights reserved.

  2. Neutrino mass: Recent results

    International Nuclear Information System (INIS)

    Robertson, R.G.H.

    1989-01-01

    Some recent developments in the experimental search for neutrino mass are discussed. Simpson and Hime report finding new evidence for a 17-keV neutrino in the β decay of 3 H and 35 S. New data from Los Alamos on the electron neutrino mass as measured in tritium beta decay give an upper limit of 13.5 eV at the 95% confidence level. This result is not consistent with the long-standing ITEP result of 26(5) eV within a ''model-independent'' range of 17 to 40 eV. It now appears that the electron neutrino is not sufficiently massive to close the universe by itself. 38 refs., 1 figs., 2 tabs

  3. Experimental results from Stripa

    International Nuclear Information System (INIS)

    Hood, M.

    1979-06-01

    The results indicate that the temperature fields in a rock mass containing geologic discontinuities can be predicted accurately using the simple theory of heat conduction. Geologic discontinuities appear to introduce significant nonlinear thermomechanical deformation into the rock mass, as a result of which the thermally induced displacements are much less than those predicted by the simple theory of thermo-elasticity. In addition, the assumption that the rock properties are temperature independent appears to increase the values predicted for these displacements significantly. Therefore, it is important that the temperature dependence of these properties is known and that these values be used in the calculations. The onset of significant thermal spalling along the walls of the heater boreholes appears to be related to conditions where the maximum induced compressive stress exceeds the uniaxial compressive strength of the rock. 7 figures

  4. Envirhom: stakes and results

    International Nuclear Information System (INIS)

    2006-01-01

    After a recall of the evolution of the international system for the protection against ionizing radiations, this report discusses the evolution of a new societal context (evolution of risk perception, concern about accidental situations). It also discusses the emerging scientific issues and challenges regarding the knowledge about biological and health effects of ionizing radiations, which requires investigations on the ecosystems, the effects of chronic low level exposures, and the propagation of effects at different biological levels (cells, tissue, individual, population, communities, and ecosystems). Then, it presents the IRSN environment-health research program, ENVIRHOM, its objectives, and its results concerning the environment on the one side, and health on the other side. The 'environment' side and the 'health' side of this program are then more precisely presented as well as their results

  5. Solar results purchasing

    International Nuclear Information System (INIS)

    Sanders, J.

    2001-01-01

    Solar Thermal water heating has made little market penetration in some European countries. The main barriers to market development are: Long payback periods for the technology; Difficulties for the end-user in meeting the initial capital costs of the installation; Lack of confidence in the delivered energy that can be expected from the technology. The third barrier has been addressed using the concept of Guaranteed Solar Results (GSR). This project has addressed the other two main barriers using the concept of Solar Results Purchasing, (SRP) which combines GSR with Third Party Financing. The work was carried out in the UK, France, and Spain. The project used a uniform approach across the three countries. Each team calculated solar performance using an English version of the SOLO programme developed by TECSOL in France to encode the methodology for GSR model contracts. (author)

  6. Final NOMAD results on $\

    CERN Document Server

    Astier, P.; Baldisseri, A.; Baldo-Ceolin, M.; Banner, M.; Bassompierre, G.; Benslama, K.; Besson, N.; Bird, I.; Blumenfeld, Barry J.; Bobisut, F.; Bouchez, J.; Boyd, S.; Bueno, A.; Bunyatov, S.; Camilleri, L.; Cardini, A.; Cattaneo, P.W.; Cavasinni, V.; Cervera-Villanueva, A.; Chukanov, A.; Collazuol, G.; Conforto, G.; Conta, C.; Contalbrigo, M.; Cousins, R.; Daniels, D.; Degaudenzi, H.; Del Prete, T.; De Santo, A.; Dignan, T.; Di Lella, L.; do Couto e Silva, E.; Dumarchez, J.; Ellis, Malcolm; Feldman, G.J.; Ferrari, R.; Ferrere, D.; Flaminio, V.; Fraternali, M.; Gaillard, J.M.; Gangler, E.; Geiser, A.; Geppert, D.; Gibin, D.; Gninenko, S.; Godley, A.; Gomez-Cadenas, J.J.; Gosset, J.; Gossling, C.; Gouanere, M.; Grant, A.; Graziani, G.; Guglielmi, A.; Hagner, C.; Hernando, J.; Hubbard, D.; Hurst, P.; Hyett, N.; Iacopini, E.; Joseph, C.; Juget, F.; Kirsanov, M.; Klimov, O.; Kokkonen, J.; Kovzelev, A.; Krasnoperov, A.; Kustov, D.; Kuznetsov, V.E.; Lacaprara, S.; Lachaud, C.; Lakic, B.; Lanza, A.; La Rotonda, L.; Laveder, M.; Letessier-Selvon, A.; Levy, J.M.; Linssen, L.; Ljubicic, A.; Long, J.; Lupi, A.; Marchionni, A.; Martelli, F.; Mechain, X.; Mendiburu, J.P.; Meyer, J.P.; Mezzetto, M.; Mishra, S.R.; Moorhead, G.F.; Naumov, D.; Nedelec, P.; Nefedov, Yu.; Nguyen-Mau, C.; Orestano, D.; Pastore, F.; Peak, L.S.; Pennacchio, E.; Pessard, H.; Petti, R.; Placci, A.; Polesello, G.; Pollmann, D.; Polyarush, A.; Popov, B.; Poulsen, C.; Rico, J.; Riemann, P.; Roda, C.; Rubbia, A.; Salvatore, F.; Schahmaneche, K.; Schmidt, B.; Schmidt, T.; Sconza, A.; Sevior, M.; Sillou, D.; Soler, F.J.P.; Sozzi, G.; Steele, D.; Stiegler, U.; Stipcevic, M.; Stolarczyk, T.; Tareb-Reyes, M.; Taylor, G.N.; Tereshchenko, V.; Toropin, A.; Touchard, A.M.; Tovey, S.N.; Tran, M.T.; Tsesmelis, E.; Ulrichs, J.; Vacavant, L.; Valdata-Nappi, M.; Valuev, V.; Vannucci, F.; Varvell, K.E.; Veltri, M.; Vercesi, V.; Vidal-Sitjes, G.; Vieira, J.M.; Vinogradova, T.; Weber, F.V.; Weisse, T.; Wilson, F.F.; Winton, L.J.; Yabsley, Bruce D.; Zaccone, H.; Zuber, K.; Zuccon, P.; Krasnoperov, A V

    2001-01-01

    Results from the nu_tau appearance search in a neutrino beam using the full NOMAD data sample are reported. A new analysis unifies all the hadronic tau decays, significantly improving the overall sensitivity of the experiment to oscillations. The "blind analysis" of all topologies yields no evidence for an oscillation signal. In the two-family oscillation scenario, this sets a 90% C.L. allowed region in the sin^2(2theta)-Delta m^2 plane which includes sin^2(2theta)nu_tau oscillation hypothesis results in sin^2(2theta)<1.5 x 10^{-2} at large Delta m^2 and Delta m^2 < 5.9 eV^2/c^4 at sin^2(2theta)=1. We also derive limits on effective couplings of the tau lepton to nu_mu or nu_e.

  7. Results from LEP

    International Nuclear Information System (INIS)

    Pohl, M.

    1995-01-01

    Selected results from LEP on electroweak neutral currents and strong interactions are reviewed. In the first part, total cross sections, angular and polarization symmetries are interpreted in terms of basic electroweak parameters, like the mass, total and partial widths of the Z and neutral current couplings. Special attention is given to two apparent problems: the discrepancy between the measurements with final state vs. initial state polarization; and the deviation of the measured width of the Z into heavy quarks from Standard Model expectations. These discrepancies are not very significant, but they are the only ones observed at this point and thus deserve attention. In the second part, I outline results on final state strong interactions, namely measurements pertaining to differences between quark and gluon jets and the QCD group structure. (author) 19 figs., 4 tabs., 21 refs

  8. EPA's radon study results

    International Nuclear Information System (INIS)

    Dowd, R.M.

    1988-01-01

    Last winter, in cooperation with agencies in 10 states and two metropolitan area counties, EPA measured the indoor air radon concentrations of 14,000 houses, some chosen statistically at random and some by request of the homeowner. Passive measurement methodologies were used, such as exposing a charcoal canister to the air for a few days and allowing the air to migrate in to the charcoal naturally. To reduce dilution of radon by the outside air, the protocol required that the house be shut up; therefore, the study was conducted during winter. The measuring device was placed in the lowest livable area (usually the basement) of each house to maximize potential concentration. It should be noted that these procedures are generally considered to be screening tests because they result in a worst-case measurement rather than a best value. The results of these findings are presented

  9. Solar results purchasing

    Energy Technology Data Exchange (ETDEWEB)

    Sanders, J.

    2001-07-01

    Solar Thermal water heating has made little market penetration in some European countries. The main barriers to market development are: Long payback periods for the technology; Difficulties for the end-user in meeting the initial capital costs of the installation; Lack of confidence in the delivered energy that can be expected from the technology. The third barrier has been addressed using the concept of Guaranteed Solar Results (GSR). This project has addressed the other two main barriers using the concept of Solar Results Purchasing, (SRP) which combines GSR with Third Party Financing. The work was carried out in the UK, France, and Spain. The project used a uniform approach across the three countries. Each team calculated solar performance using an English version of the SOLO programme developed by TECSOL in France to encode the methodology for GSR model contracts. (author)

  10. Results from SAGE

    International Nuclear Information System (INIS)

    Abdurashitov, J.N.; Gavrin, V.N.; Girin, S.V.

    1996-01-01

    The Russian-American Gallium Solar Neutrino Experiment (SAGE) is described. Beginning in September 1992, SAGE II data were taken with 55 tons of Ga and with significantly reduced backgrounds. The solar neutrino flux measured by 31 extractions through October 1993 is presented. The result of 69 ± 10 +5/-7 SNU is to be compared with a Standard Solar Model prediction of 132 SNU

  11. Statistical mechanics rigorous results

    CERN Document Server

    Ruelle, David

    1999-01-01

    This classic book marks the beginning of an era of vigorous mathematical progress in equilibrium statistical mechanics. Its treatment of the infinite system limit has not been superseded, and the discussion of thermodynamic functions and states remains basic for more recent work. The conceptual foundation provided by the Rigorous Results remains invaluable for the study of the spectacular developments of statistical mechanics in the second half of the 20th century.

  12. Recent results from JADE

    International Nuclear Information System (INIS)

    Nozaki, M.

    1983-01-01

    Recent results from JADE are reported. The JADE experiment is being carried out by a collaboration of DESY, Universities of Hamburg, Heidelburg, Lancaseter and Manchester, Rutherford Laboratory and University of Tokyo. It was proposed in 1976 and after 3 years construction, the JADE started data taking at the e/sup +/e/sup -/ colliding beam facility PETRA with a complete set of detector components in June 1979

  13. Assessing ultrasonic examination results

    International Nuclear Information System (INIS)

    Deutsch, V.; Vogt, M.

    1977-01-01

    Amongst nondestructive examination methods, the ultrasonic examination plays an important role. The reason why its scope of application is so wide is because the sound conducting capacity is the only property the material of a test specimen has to have. As the fields are so manifold, only main aspects can be described briefly. The list of references, however, is very extensive and gives plenty of information of all the problems concerning the assessment of ultrasonic examination results. (orig./RW) [de

  14. Recent results from LHCb

    CERN Document Server

    Oblakowska-Mucha, A

    2016-01-01

    The LHCb detector is a single-arm forward spectrometer that collects data at the LHC. In this review, a few of recent results in the field of $b$-hadron decays performed by the LHCb Collaboration are presented. The analyses use proton-proton collision data corresponding to 3 fb$^{-1}$ collected by the LHCb detector during 2011 and 2012 physics runs with the center-of-mass energies of 7 and 8 TeV.

  15. Pressure locking test results

    Energy Technology Data Exchange (ETDEWEB)

    DeWall, K.G.; Watkins, J.C.; McKellar, M.G.; Bramwell, D. [Idaho National Engineering Lab., Idaho Falls, ID (United States)] [and others

    1996-12-01

    The U.S. Nuclear Regulatory Commission (NRC), Office of Nuclear Regulatory Research, is funding the Idaho National Engineering Laboratory (INEL) in performing research to provide technical input for their use in evaluating responses to Generic Letter 95-07, {open_quotes}Pressure Locking and Thermal Binding of Safety-Related Power-Operated Gate Valves.{close_quotes} Pressure locking and thermal binding are phenomena that make a closed gate valve difficult to open. This paper discusses only the pressure locking phenomenon in a flexible-wedge gate valve; the authors will publish the results of their thermal binding research at a later date. Pressure locking can occur when operating sequences or temperature changes cause the pressure of the fluid in the bonnet (and, in most valves, between the discs) to be higher than the pressure on the upstream and downstream sides of the disc assembly. This high fluid pressure presses the discs against both seats, making the disc assembly harder to unseat than anticipated by the typical design calculations, which generally consider friction at only one of the two disc/seat interfaces. The high pressure of the bonnet fluid also changes the pressure distribution around the disc in a way that can further contribute to the unseating load. If the combined loads associated with pressure locking are very high, the actuator might not have the capacity to open the valve. The results of the NRC/INEL research discussed in this paper show that the relationship between bonnet pressure and pressure locking stem loads appears linear. The results also show that for this valve, seat leakage affects the bonnet pressurization rate when the valve is subjected to thermally induced pressure locking conditions.

  16. Pressure locking test results

    International Nuclear Information System (INIS)

    DeWall, K.G.; Watkins, J.C.; McKellar, M.G.; Bramwell, D.

    1996-01-01

    The U.S. Nuclear Regulatory Commission (NRC), Office of Nuclear Regulatory Research, is funding the Idaho National Engineering Laboratory (INEL) in performing research to provide technical input for their use in evaluating responses to Generic Letter 95-07, open-quotes Pressure Locking and Thermal Binding of Safety-Related Power-Operated Gate Valves.close quotes Pressure locking and thermal binding are phenomena that make a closed gate valve difficult to open. This paper discusses only the pressure locking phenomenon in a flexible-wedge gate valve; we will publish the results of our thermal binding research at a later date. Pressure locking can occur when operating sequences or temperature changes cause the pressure of the fluid in the bonnet (and, in most valves, between the discs) to be higher than the pressure on the upstream and downstream sides of the disc assembly. This high fluid pressure presses the discs against both seats, making the disc assembly harder to unseat than anticipated by the typical design calculations, which generally consider friction at only one of the two disc/seat interfaces. The high pressure of the bonnet fluid also changes the pressure distribution around the disc in a way that can further contribute to the unseating load. If the combined loads associated with pressure locking are very high, the actuator might not have the capacity to open the valve. The results of the NRC/INEL research discussed in this paper show that the relationship between bonnet pressure and pressure locking stem loads appears linear. The results also show that for this valve, seat leakage affects the bonnet pressurization rate when the valve is subjected to thermally induced pressure locking conditions

  17. Scientific results report 1980

    International Nuclear Information System (INIS)

    1981-01-01

    The report describes in concise form the research tasks and results of the work groups pulsed irradiation, reaction kinematics and insulators and plastics in the field of 'radiation chemistry' of the Hahn-Meitner Institute, Berlin. The main topic of investigation was the kinetics and dynamics of fast chemical processes, the setting-up of chemical reaction mechanisms and research of chemical physical properties of highly reactive species (radicals, ions, electrons). A list of publications and lectures as well as teaching contributions of the institute's scientists, diploma and doctor theses performed in the institute and guest lectures held there is also given. (RB) [de

  18. Recent CLEO Results

    International Nuclear Information System (INIS)

    Ecklund, Karl M.

    2004-01-01

    I report B physics results from the CLEO collaboration, highlighting measurements of the Cabibbo-Kobayashi-Maskawa matrix elements vertical bar Vcb vertical bar and vertical bar Vub vertical bar. I report a recent measurement of vertical bar Vub vertical bar through study of the q2 dependence of B-bar → πlv-bar and B-bar → ρlv-bar. I also describe new measurements of the inclusive semileptonic branching fraction B(B-bar → Xev-bar) and of moments of the hadronic invariant mass spectrum in B-bar → Xlv-bar, with impact on vertical bar Vcb vertical bar

  19. New results from CERES

    CERN Document Server

    Adamova, D; Appelshäuser, H; Belaga, V V; Braun-Munzinger, P; Cherlin, A; Damjanovic, S; Dietel, T; Dietrich, L; Drees, A; Esumi, S C; Filimonov, K; Fomenko, K; Fraenkel, Zeev; Garabatos, C; Glässel, P; Hering, G; Holender, J M; Kushpil, V; Lenkeit, B C; Maas, A; Marin, A; Messer, F; Milosevic, J; Milov, A; Miskowiec, D; Panebratsev, Yu A; Petchenova, O Yu; Petracek, V; Pfeiffer, A; Rak, J; Ravinovich, I; Rehak, P; Sako, H; Schmitz, W; Schükraft, Jürgen; Sedykh, S N; Seipp, W; Shimansky, S S; Slivova, J; Specht, H J; Stachel, J; Sumbera, M; Tilsner, H; Tserruya, Itzhak; Wessels, J P; Wienold, T; Windelband, B; Wurm, J P; Xie, W; Yurevich, S; Yurevich, V I

    2002-01-01

    We will focus here on results from the 1999 data taking period, where 8 M Pb+Au events at 40 AGeV were recorded. Since the new readout system of the TPC was not yet properly working, this data set is limited in terms of statistics, and momentum resolution. Nevertheless, this data sample at lower beam energy allows to study initial conditions different from the ones at top SPS energy. This can be very useful to disentangle temperature and baryon density driven modifications of the dilepton spectrum. (15 refs).

  20. Latest results from JET

    International Nuclear Information System (INIS)

    Bickerton, R.J.

    1989-01-01

    The Joint European Torus (JET) is a large tokamak designed with the essential objective of obtaining and studying plasmas with parameters close to those envisaged for an eventual power-generating, nuclear-fusion reactor. JET is situated on a site near Abingdon, Oxon, UK. JET is the largest single project of the nuclear fusion research programme of the European Atomic Energy Community (EURATOM). The tokamak started operation in mid 1983 after a five year construction period. The scientific and technical results achieved so far are summarised in this article. (orig.)

  1. Recent results from SPEAR

    International Nuclear Information System (INIS)

    Wacker, K.

    1983-09-01

    The first part of this talk is an experimental review of the properties of the THETA meson. Results or upper limits come from radiative j/psi decays and γγ scattering for the final states eta eta, ππ, K anti K and rho rho. In the second part, an upper limit is given for the production of low-mass particles in radiative J/psi decays. Constraints for the existence of low-mass gluonic and Higgs mesons are derived

  2. Results of railgun experiments

    International Nuclear Information System (INIS)

    Hawke, R.S.; Brooks, A.L.; Fowler, C.M.; Peterson, D.R.

    1983-04-01

    During the 1979 Megagauss II conference the hypervelocity potential of railguns and the pulsed power technology needed to power them were discussed. Since then, many laboratories have initiated railgun R and D projects for a variety of potential applications. Los Alamos and Lawrence Livermore National Laboratories initiated a collaborative experimental railgun project which resulted in several successes in accelerating projectiles to high velocities, emphasized the limits on railgun operation, and indicated that the numerical modeling of railgun operation was in good agreement with the experiments

  3. Results from neutrino experiments

    International Nuclear Information System (INIS)

    Smirnov, A.Yu.

    1993-11-01

    Recent (first or/and the best) results from the neutrino experiments are reviewed and their implications for the theory are discussed. The sense of the experiments is the searching for neutrino masses, mixing and interactions beyond the standard model. Present laboratory experiments give upper bounds on the masses and the mixing which are at the level of predictions of the ''electroweak see-saw''. Positive indications of nonzero lepton mixing follow from studies of the solar and atmospheric neutrinos. (author). 95 refs, 11 figs

  4. Results from AMANDA

    CERN Document Server

    Wiebusch, C; Bai, X; Barwick, S W; Becka, T; Becker, K H; Bertrand, D; Bernadini, E; Binon, Freddy G; Biron, A; Boser, S; Botner, O; Bouchta, A; Bouhali, O; Burgess, T; Carius, S; Castermans, T; Chen, A; Chirkin, D; Conrad, J; Cooley, J; Cowen, D F; Davour, A; De Clercq, C; De Young, T R; Desiati, P; Dewulf, J P; Doksus, P; Ekstrom, P; Feser, T; Gaisser, T K; Gaug, M; Gerhardt, L; Goldschmidt, A; Hallgren, A; Halzen, F; Hanson, K; Hardtke, R; Hauschildt, T; Hellwig, M; Herquet, P; Hill, G C; Hulth, P O; Hundertmark, S; Jacobsen, J; Karle, A; Koci, B; Köpke, L; Kowalski, M; Kühn, K; Lamoureux, J I; Leich, H; Leuthold, M J; Lindahl, P; Liubarsky, I; Madsen, J; Marciniewski, P; Matis, H S; McParland, C P; Minaeva, Y; Minocinovic, P; Mock, P C; Morse, R; Nahnhauer, R; Neunhoffer, T; Niessen, P; Nygren, D R; Ögelman, H B; Olbrechts, P; Pérez de los Heros, C; Pohl, A C; Price, P B; Przybylski, G T; Rawlins, K; Resconi, E; Rhode, W; Ribordy, M; Richter, S; Rodríguez-Martino, J; Ross, D; Sander, H G; Schmidt, T; Schneider, D; Schwarz, R; Silvestri, A; Solarz, M; Spiczak, G M; Spiering, C; Steele, D; Steffen, P; Stokstad, R G; Sudhoff, P; Sulanke, K H; Taboada, I; Thollander, L; Tilav, S; Walck, C; Weinheimer, C; Wiebusch, C; Wiedemann, C; Wischnewski, R; Wissing, H; Woschnagg, K; Yodh, G B; Young, S

    2002-01-01

    The Antarctic Muon and Neutrino Detector Array (AMANDA) is a high- energy neutrino telescope operating at the geographic South Pole. It is a lattice of photomultiplier tubes buried deep in the polar ice. The primary goal of this detector is to discover astrophysical sources of high energy neutrinos. We describe the detector methods of operation and present results from the AMANDA-B10 prototype. We demonstrate the improved sensitivity of the current AMANDA-II detector. We conclude with an outlook to the envisioned sensitivity of the future IceCube detector. (37 refs).

  5. Results from PAMELA

    International Nuclear Information System (INIS)

    Mocchiutti, E.; Adriani, O.; Barbarino, G.C.; Bazilevskaya, G.A.; Bellotti, R.; Boezio, M.; Bogomolov, E.A.; Bonechi, L.; Bongi, M.; Bonvicini, V.; Borisov, S.; Bottai, S.; Bruno, A.; Cafagna, F.; Campana, D.

    2011-01-01

    The PAMELA satellite experiment was launched into low earth orbit on June 15th 2006. The combination of a permanent magnet silicon strip spectrometer and a silicon-tungsten imaging calorimeter allows precision studies of the charged cosmic radiation to be conducted over a wide energy range (100 MeV - several hundred GeV). A primary scientific goal is to search for dark matter particle annihilation by measuring the energy spectra of cosmic ray antiparticles. Latest results from the PAMELA experiment are presented with a particular focus on cosmic ray antiprotons and positrons.

  6. Overview of Tokamak Results

    International Nuclear Information System (INIS)

    Unterberg, Bernhard; Samm, Ulrich

    2004-01-01

    An overview is given of recent results obtained in tokamak devices. We introduce basic confinement scenarios as L-mode, H-mode and plasmas with an internal transport barrier and discuss methods for profile control. Important findings in DT-experiments at JET as α-particle heating are described. Methods for power exhaust like plasma regimes with a radiating mantle and radiative divertor scenarios are discussed. The overall impact of plasma edge conditions on the general plasma performance in tokamaks is illustrated by describing the impact of wall conditions on confinement and the edge operational diagram of H-mode plasmas

  7. Recent CDF results

    International Nuclear Information System (INIS)

    Conway, J.S.

    1996-07-01

    Preliminary results form the CDF detector, based on analysis of data collected in Run 1a and Run 1b at the Tevatron, totaling 110 pb - 1 integrated luminosity, place new limits on the masses and couplings of new particles including charged Higgs bosons, supersymmetric gauge particles and quarks, and new vector bosons. One of the observed events, having an e + e - pair, two photons, and large missing energy would not occur with significant rate in the Standard Model, leading to speculation regarding its origin and the possible existence of related events

  8. Recent BABAR Results

    Energy Technology Data Exchange (ETDEWEB)

    Eigen, Gerald [University of Bergen, Bergen (Norway). Dept. of Physics

    2015-04-29

    We present herein the most recent BABAR results on direct CP asymmetry measurements in B → Xsγ, on partial branching fraction and CP asymmetry measurements in B → Xs+-, on a search for B → π/ηℓ+- decays, on a search for lepton number violation in B+ → X-+ℓ'+ modes and a study of B0 →ωω and B0 → ωφ decays.

  9. Spacelab Science Results Study

    Science.gov (United States)

    Naumann, R. J.; Lundquist, C. A.; Tandberg-Hanssen, E.; Horwitz, J. L.; Germany, G. A.; Cruise, J. F.; Lewis, M. L.; Murphy, K. L.

    2009-01-01

    Beginning with OSTA-1 in November 1981 and ending with Neurolab in March 1998, a total of 36 Shuttle missions carried various Spacelab components such as the Spacelab module, pallet, instrument pointing system, or mission peculiar experiment support structure. The experiments carried out during these flights included astrophysics, solar physics, plasma physics, atmospheric science, Earth observations, and a wide range of microgravity experiments in life sciences, biotechnology, materials science, and fluid physics which includes combustion and critical point phenomena. In all, some 764 experiments were conducted by investigators from the U.S., Europe, and Japan. The purpose of this Spacelab Science Results Study is to document the contributions made in each of the major research areas by giving a brief synopsis of the more significant experiments and an extensive list of the publications that were produced. We have also endeavored to show how these results impacted the existing body of knowledge, where they have spawned new fields, and if appropriate, where the knowledge they produced has been applied.

  10. Results from TOTEM

    Directory of Open Access Journals (Sweden)

    Eggert Karsten

    2013-06-01

    Full Text Available The TOTEM experiment at the CERN LHC is focussed on the measurement of the elastic proton-proton scattering, the total pp cross-section, and all kinds of diffractive phenomena. Detectors housed in “Roman Pots” which can be moved close to the outgoing proton beams allow to trigger on elastic and diffractive protons and to determine their parameters like the momentum loss and the transverse momentum transfer. In addition, charged particle detectors in the forward regions detect almost all inelastic events. Together with the CMS detector, a large solid angle is covered enabling precise studies of Min. Bias as well as Single Diffractive and Double Pomeron Interactions. The results will considerably help the interpretation of the Cosmic Ray Showers at highest energies and will give insight into the proton structure and the QCD theory of strong interactions. TOTEM measured the elastic pp- scattering over a large range of t (the squared momentum transfer from 10-3 – 4 GeV2. Noneof the considered models could yield a satisfactory fit over the complete range. However, the exponential slope at low |t|-values and the position of the diffractiveminimum are well within the extrapolation from lower energies. The total pp cross-section has been determined in different ways from the extrapolation of the elasticscattering to t=0 (optical point and the inelastic rate: (i From the elastic scattering using the optical theorem and the CMS, (ii luminosity independently, usingthe inelastic rate, elastic scattering and the optical theorem, (iiiρ independently, by using elastic scattering, inelastic rate and the CMS luminosity. The results for the total crosssection obtained from the different methods are in excellent agreement with each other. First studies of the data on diffractive phenomena havebeen performed by correlating the momentum loss of the forward protons with the topology of the particle flux. The data look very promising and further studies will

  11. EIGER characterization results

    International Nuclear Information System (INIS)

    Dinapoli, Roberto; Bergamaschi, Anna; Greiffenberg, Dominic; Henrich, Beat; Horisberger, Roland; Johnson, Ian; Mozzanica, Aldo; Radicci, Valeria; Schmitt, Bernd; Shi, Xintian; Tinti, Gemma

    2013-01-01

    Characterization and performance measurements have been done on several EIGER detector systems, produced with chips coming from two different lots, both with a lab X-ray source and at the Swiss Light Source (SLS). Results on the detector calibration, electronic noise, threshold dispersion, minimum achievable energy threshold, maximum detectable incoming photon flux and maximum frame rate are presented. An EIGER module is constructed from a ∼4×8cm 2 monolithic silicon sensor bump-bonded to 2 ×4 readout chips and contains 0.5 Mpixel. The first EIGER 500 K systems have been produced and images taken with these detectors are shown. Modules can be tiled together to form large area detectors; both a 9 Mpixel and a 16 Mpixel systems are at present under development for the coherent small angle X-ray scattering and protein crystallography beamlines of the SLS

  12. EIGER characterization results

    Energy Technology Data Exchange (ETDEWEB)

    Dinapoli, Roberto, E-mail: roberto.dinapoli@psi.ch [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Bergamaschi, Anna; Greiffenberg, Dominic; Henrich, Beat; Horisberger, Roland; Johnson, Ian; Mozzanica, Aldo [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Radicci, Valeria [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); ESRF, 6 Rue Horowitz, 38043 Grenoble (France); Schmitt, Bernd; Shi, Xintian [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Tinti, Gemma [Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); ESRF, 6 Rue Horowitz, 38043 Grenoble (France)

    2013-12-11

    Characterization and performance measurements have been done on several EIGER detector systems, produced with chips coming from two different lots, both with a lab X-ray source and at the Swiss Light Source (SLS). Results on the detector calibration, electronic noise, threshold dispersion, minimum achievable energy threshold, maximum detectable incoming photon flux and maximum frame rate are presented. An EIGER module is constructed from a ∼4×8cm{sup 2} monolithic silicon sensor bump-bonded to 2 ×4 readout chips and contains 0.5 Mpixel. The first EIGER 500 K systems have been produced and images taken with these detectors are shown. Modules can be tiled together to form large area detectors; both a 9 Mpixel and a 16 Mpixel systems are at present under development for the coherent small angle X-ray scattering and protein crystallography beamlines of the SLS.

  13. Recent results from CMS

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    With the increase in center-of-mass energy, a new energy frontier has been opened by the Large Hadron Collider. More than 25 fb^-1 of proton-proton collisions at sqrt(s)=13 TeV have been delivered to both ATLAS and CMS experiments during 2016. This enormous dataset can be used to test the Standard Model in a complete new regime with tremendous precision and it has the potential to unveil new physics or set strong bounds on it. In this talk some of the most recent results made public by the CMS Collaboration will be presented. The focus will mainly be on searches for physics beyond the Standard Model, with particular emphasis on searches for dark matter candidates.

  14. Scientific results - report 1981

    International Nuclear Information System (INIS)

    1982-01-01

    During the year under report 1981, five working groups were active in the field of nuclear chemistry: neutron diffraction, radiation damage in solids, reactor chemistry, trace element research in bio-medicine and geo-chemistry. The objectives of the R+D projects ranged from the more basic research to the development of technological processes. Nuclear inspection methodes that have already been developed (e.g. neutron diffraction, trace element analysis) have increasingly been used in an interdisciplinary way. Besides these R+D projects the project of increase of power of the BER II was pursued also in 1981, and further planning documents on the extension of the BER II have been established. The report informs about the most important results of the single sections. A list of the publications (with abstracts) and lectures, also by guest scientists, is attached. (RB) [de

  15. Payment by Results

    Directory of Open Access Journals (Sweden)

    Brendan A. Rapple

    1994-01-01

    Full Text Available Today the public is demanding that it exercise more control over how tax dollars are spent in the educational sphere, with multitudes also canvassing that education become closely aligned to the marketplace's economic forces. In this paper I examine an historical precedent for such demands, i.e. the comprehensive 19th century system of accountability, "Payment by Results," which endured in English and Welsh elementary schools from 1862 until 1897. Particular emphasis is focused on the economic market-driven aspect of the system whereby every pupil was examined annually by an Inspector, the amount of the governmental grant being largely dependent on the answering. I argue that this was a narrow, restrictive system of educational accountability though one totally in keeping with the age's pervasive utilitarian belief in laissez-faire. I conclude by observing that this Victorian system might be suggestive to us today when calls for analogous schemes of educational accountability are shrill.

  16. Latest results from LUNA

    Science.gov (United States)

    Depalo, Rosanna; LUNA Collaboration

    2018-01-01

    A precise knowledge of the cross section of nuclear fusion reactions is a crucial ingredient in understanding stellar evolution and nucleosynthesis. At stellar temperatures, fusion cross sections are extremely small and difficult to measure. Measuring nuclear cross sections at astrophysical energies is a challenge that triggered a huge amount of experimental work. A breakthrough in this direction was the first operation of an underground accelerator at the Laboratory for Underground Nuclear Astrophysics (LUNA) in Gran Sasso, Italy. The 1400 meters of rocks above the laboratory act as a natural shield against cosmic radiation, suppressing the background by orders of magnitude. The latest results achieved at LUNA are discussed, with special emphasis on the 22Ne(p,γ)23Na reaction. Future perspectives of the LUNA experiment are also illustrated.

  17. Overview of HERMES results

    Directory of Open Access Journals (Sweden)

    Van Hulse Charlotte

    2016-01-01

    Full Text Available The HERMES experiment has collected a wealth of deep-inelastic scattering data using the 27.6 GeV polarized lepton beam at HERA and various pure gas targets, both unpolarized and polarized. This allowed for a series of diverse and unique measurements. Among them are measurements that provide information on the threedimensional structure of the nucleon, both in momentum space and in position space. Results of measurements of exclusive ω production on an unpolarized and transversely polarized nucleon target, sensitive to the distribution in transverse-position and longitudinalmomentum space, are discussed as well as the three-dimensional extraction of azimuthal asymmetries measured in semi-inclusive deep-inelastic scattering, sensitive to twist-2 and twist-3 distributions in three-dimensional momentum space.

  18. Latest results from ALICE

    CERN Document Server

    Scapparone, Eugenio

    2011-01-01

    In this paper selected results obtained by the ALICE experiment at the LHC will be presented. Data collected during the pp runs taken at sqrt(s)=0.9, 2.76 and 7 TeV and Pb-Pb runs at sqrt(s_NN)=2.76 TeV allowed interesting studies on the properties of the hadronic and nuclear matter: proton runs gave us the possibility to explore the ordinary matter at very high energy and up to very low pt, while Pb-Pb runs provided spectacular events where several thousands of particles produced in the interaction revealed how a very dense medium behaves, providing a deeper picture on the quark gluon plasma(QGP) chemical composition and dynamics.

  19. Recent Results from Phobos

    Science.gov (United States)

    García, Edmundo; Back, B. B.; Baker, M. D.; Ballintijn, M.; Barton, D. S.; Betts, R. R.; Bickley, A. A.; Bindel, R.; Busza, W.; Carroll, A.; Chai, Z.; Decowski, M. P.; García, E.; Gburek, T.; George, N.; Gulbrandsen, K.; Halliwell, C.; Hamblen, J.; Hauer, M.; Henderson, C.; Hofman, D. J.; Hollis, R. S.; Hołyński, R.; Holzman, B.; Iordanova, A.; Johnson, E.; Kane, J. L.; Khan, N.; Kulinich, P.; Kuo, C. M.; Lin, W. T.; Manly, S.; Mignerey, A. C.; Nouicer, R.; Olszewski, A.; Pak, R.; Reed, C.; Roland, C.; Roland, G.; Sagerer, J.; Seals, H.; Sedykh, I.; Smith, C. E.; Stankiewicz, M. A.; Steinberg, P.; Stephans, G. S. F.; Sukhanov, A.; Tonjes, M. B.; Trzupek, A.; Vale, C.; van Nieuwenhuizen, G. J.; Vaurynovich, S. S.; Verdier, R.; Veres, G. I.; Wenger, E.; Wolfs, F. L. H.; Wosiek, B.; Woźniak, K.; Wysłouch, B.

    2007-02-01

    The PHOBOS detector is one of four heavy ion experiments at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory. In this paper we will review some of the results of PHOBOS from the data collected in p+p, d+Au and Au+Au collisions at nucleon-nucleon center-of-mass energies up to 200 GeV. Evidence is found of the formation of a very high energy density and highly interactive system, which can not be described in terms of hadrons, and has a relatively low baryon density. There is evidence that the system formed is thermalized to a certain degree. Scaling with the number of participants and extended longitudinal scaling behavior are also observed in distributions of produced charged particles.

  20. Recent results from LHCf

    Directory of Open Access Journals (Sweden)

    Menjo H.

    2015-01-01

    Full Text Available The LHCf experiment is one of the LHC forward experiments. The aim of LHCf is to provide critical calibration data of hadronic intraction models used in air shower simulations. The LHCf has completed the operations for p-p collisions with a collision energy of √s = 0.9 and 7 TeV p-p in 2010 and for p-Pb collisions with a collision energy per nucleon of √sNN = 5.02. The recent LHCf result of forward neutron energy spectra at 7 TeV p-p collision and forward π0 spectra at p-Pb collisions are presented in this paper.

  1. Results and discussion

    International Nuclear Information System (INIS)

    1998-01-01

    The author deals with the experimental study of sorption, desorption and vertical migration of radionuclides in Sr-85 and Cs-137 in selected soil samples from around of NPP Bohunice and NPP Mochovce and other localities of the Slovakia. The influence of different materials [concurrent ions (K + , Ca 2+ , NH 4 + , pH), organic matter (peat) and zeolite, humidity] on kinetic of sorption and desorption of strontium and cesium as well as distribution coefficient (K D ) and transfer coefficients in followed samples of soils were followed. Obtained adsorption isotherm are presented and discussed. Using the Tessiere's sequential extraction analysis a gross variability in binding of radionuclides on soils was found. The obtained results were processed with the correlation analysis and the compartment model

  2. Areva - 2011 Annual results

    International Nuclear Information System (INIS)

    Marie, Patricia; Briand, Pauline; Michaut, Maxime; Scorbiac, Marie de; Repaire, Philippine du

    2012-01-01

    Areva's backlog established at 45.6 billion euros at the end of 2011, significantly increasing at the end of a year marked by the Fukushima accident, confirms the commercial dynamism of the group alongside its customers and reinforces the visibility on its future business level. In a difficult context, the slight decline in revenue in 2011 demonstrates the robustness of Areva's integrated model, resting mainly on recurring business generated in relation to Areva's customers' nuclear installed base, and benefiting from the development of Areva's renewable energies operations. Free operating cash flow before tax, although down over the whole year in 2011, improved in the second half, showing the first effects of Areva's stronger focus on cash generation and debt management. After the success of Areva's bond issue in September 2011, the Group's liquidity remains high at the end of 2011. The Areva teams are now dedicating all of their efforts to the deployment of the 'Action 2016' strategic action plan, which had already yielded its first positive results at the end of 2011, with an improvement in the cost structure of Areva's operations, an increase in order intake, and the launch of several disposals of minority interests. Summary of the 2011 financial results: - Backlog: euro 45.6 bn, +3.1% vs. 2010, i.e +6.7% over 3 months; - Revenue: euro 8.872 bn, i.e -2.6% vs. 2010; - Operating income: - euro 1.923 bn; - Net income attributable to equity owners of the parent: - euro 2.424 bn; - EBITDA: euro 1.068 bn ( euro 420 m excluding Siemens impact); - Free operating cash flow before tax: - euro 2.397 bn (- euro 1.366 bn excluding Siemens impacts), improvement over the second half; - Decrease in net debt of euro 124 m for the year; - Significant drop in general and administrative expenses, with a noticeable reduction between the first and the second half; - Launch of several disposals of minority interests

  3. Report on Results 2000

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    This report discusses work being carried out in Norway to promote energy efficiency and the production of new renewable energy. An overall review of the quantifiable results of last year's activities at national level is available. It will serve to initiate an annual reporting tradition. The report represents a step towards an ongoing process for improved targeting and management of national efforts. During the course of the year 2000, NVE has evaluated and adjusted its activities and established a system involving indicators and reporting procedures. It is also important to take notice of the long-term work being undertaken to influence people's attitudes, even though this work is difficult to assess. NVE is investing in i.a. measures aimed at children and young people. Apart from directly influencing future energy users, this investment is also having an effect due to the children's encouragement of their parents to engage in more energy and environment-friendly behaviour. Published in 2000, the IEA report ''Trends in Norwegian Stationary Energy Use'' shows that total Norwegian energy consumption per GDP is not much higher than in other IEA countries, when adjusted for cold climate and industrial structure. However, Norwegians do stand out as intensive users of electricity. The IEA report shows a reduction of 10 TWh in energy usage when compared to the projected post 1990 figures. Energy efficiency activities have contributed towards this reduction. However, the potential for a more rational use of energy in Norway is still substantial and well documented. Based on experience most enterprises could save around 10% of energy used just by making changes to their operations, i.e. without major investments. Furthermore, the potential is growing because of massive technological developments in respect of energy usage, production and distribution. With this in mind, it is necessary to take full advantage of the extensive knowledge

  4. URAT South Parallax Results

    Science.gov (United States)

    Finch, Charlie T.; Zacharias, Norbert; Jao, Wei-Chun

    2018-04-01

    We present 916 trigonometric parallaxes and proper motions of newly discovered nearby stars from the United States Naval Observatory Robotic Astrometric Telescope (URAT). Observations were taken at the Cerro Tololo Interamerican Observatory over a 2-year period from 2015 to 2017 October covering the entire sky south of about +25° decl. SPM4 and UCAC4 early epoch catalog data were added to extend the temporal coverage for the parallax and proper motion fit up to 48 years. Using these new URAT parallaxes, optical and near-IR photometry from the AAVSO Photometric All-Sky Survey and Two Micron All-Sky Survey catalogs, we identify possible new nearby dwarfs, young stars, low-metallicity subdwarfs and white dwarfs. Comparison to known trigonometric parallaxes shows a high quality of the URAT-based results confirming the error in parallax of the URAT south parallaxes reported here to be between 2 and 13 mas. We also include additional 729 trigonometric parallaxes from the URAT north 25 pc sample published in Finch & Zacharias here after applying the same criterion as for the southern sample to have a complete URAT 25 pc sample presented in this paper.

  5. ESR teleradiology survey: results.

    Science.gov (United States)

    2016-08-01

    With recent developments of teleradiology technology and services, it has become necessary to better evaluate its extent and use among different countries in Europe. With this goal in mind, the ESR launched two specific surveys intended to gather the current state of adoption and implementation of teleradiology in clinical practice. A special focus on differentiating between insourcing teleradiology services among partners of the same organisation and outsourcing to external services was an essential part of the design of these surveys. The first survey was addressed to 44 national societies of different countries in Europe, while the second survey was intended for all practicing radiologist ESR members. While the results of these surveys reported here may provide a wealth of information to better understand the trends in adoption of teleradiology in Europe, they only represent a snapshot at a certain point in time. The rapid development of telecommunication tools as well as a fundamental change in practice and healthcare economics will certainly influence these observations in the upcoming years. These data, however, will provide objective and relevant parameters for supporting the efforts of experts and policy makers in promoting appropriate criteria and guidelines for adequate use of teleradiology in clinical practice. Main Messages • Understand concepts and challenges of teleradiology • Provide insight into current trends and solutions for teleradiology • Compare differences in teleradiolgy strategies between countries in Europe • Establish a reference on statistical data of usage of teleradiology in Europe.

  6. [Maraviroc: clinical trials results].

    Science.gov (United States)

    Chidiac, C; Katlama, C; Yeni, P

    2008-03-01

    Just over a decade after identification of chemokine receptors CCR5 and CXCR4 as coreceptors for HIV, maraviroc (Celsentri), the first CCR5 antagonist, has recently obtained its Marketing Authorization in the United States and Europe, for treatment of treatment-experienced adult patients infected with only CCR5-tropic HIV-1 detectable. CCR5 antagonists, after fusion inhibitor enfuvirtide available since 2003, also belong to entry inhibitors. These molecules, unlike previous antiretrovirals, do not target the virus but its target cell by blocking viral penetration. Maraviroc has shown its clinical efficacy in patients failing other antiretroviral classes. Its safety profile was similar to placebo in two large phase III trials. However, careful assessment of both hepatic and immunologic safety of this new therapeutic class is needed. Viral tropism testing has to be investigated before using maraviroc in the clinic, because CCR5 antagonists are not active against CXCR4 viruses. For the moment indicated for the treatment-experienced patient population, maraviroc could in the future benefit to other types of patients, depending on ongoing trials results.

  7. COBE observations and results

    International Nuclear Information System (INIS)

    Smoot, G.F.

    1999-01-01

    This paper summarizes the results from the COBE satellite mission. Nine years have passed since the launch of COBE and six years since the announcement of the discovery of cosmic microwave background anisotropies by the COBE DMR instrument. This is still a relatively short time to look back and understand the implications of COBE and the anisotropy discovery; however, this 3K Cosmology Conference provides some context. The Cosmic Background Explorer (COBE) satellite has made a major contribution to the field of cosmology and has help create the confidence and high level of interest that propels the field today. Two major CMB observations, the thermal spectrum of the CMB and the CMB anisotropies, plus a host of other observations and conclusions are the basis and a major but not exclusive portion of the legacy of COBE. The recent detection and observation of the cosmic infrared background (CIB) are also part of COBE close-quote s major contribution to cosmology. copyright 1999 American Institute of Physics

  8. esophageal cancer: preliminary results

    Directory of Open Access Journals (Sweden)

    Afsaneh Maddah Safaei

    2017-01-01

    Full Text Available Purpose: Dysphagia is a common initial presentation in locally advanced esophageal cancer and negatively impacts patient quality of life and treatment compliance. To induce fast relief of dysphagia in patients with potentially operable esophageal cancer high-dose-rate (HDR brachytherapy was applied prior to definitive radiochemotherapy. Material and methods : In this single arm phase II clinical trial between 2013 to 2014 twenty patients with locally advanced esophageal cancer (17 squamous cell and 3 adenocarcinoma were treated with upfront 10 Gy HDR brachytherapy, followed by 50.4 Gy external beam radiotherapy (EBRT and concurrent chemotherapy with cisplatin/5-fluorouracil. Results : Tumor response, as measured by endoscopy and/or computed tomography scan, revealed complete remission in 16 and partial response in 4 patients (overall response rate 100%. Improvement of dysphagia was induced by brachytherapy within a few days and maintained up to the end of treatment in 80% of patients. No differences in either response rate or dysphagia resolution were found between squamous cell and adenocarcinoma histology. The grade 2 and 3 acute pancytopenia or bicytopenia reported in 4 patients, while sub-acute adverse effects with painful ulceration was seen in five patients, occurring after a median of 2 months. A perforation developed in one patient during the procedure of brachytherapy that resolved successfully with immediate surgery. Conclusions : Brachytherapy before EBRT was a safe and effective procedure to induce rapid and durable relief from dysphagia, especially when combined with EBRT.

  9. Results from SNO

    International Nuclear Information System (INIS)

    Chan, Yuen-dat

    2001-01-01

    The Sudbury Neutrino Observatory (SNO) is an underground heavy water Cherenkov detector for studying solar neutrinos. SNO is capable of performing both flavor sensitive and flavor blind measurements of the solar neutrino flux. The first charged current (CC) measurement is found to be: ψ SNO CC (ν e ) = 1.75 ± 0.07(stat.) -0.11 +0.12 (sys.) ± 0.05 (theor.) x 10 6 cm -2 s -1 and the elastic scattering fluxes (ES) is: ψ SNO ES (ν x ) = 2.39 ± 0.34(stat.) -0.14 +0.16 (sys.) x 10 6 cm -2 s -1 . The ψ SNO CC (ν e ) result, when combined with the high statistics elastic scattering (ES) measurement from Super-Kamiokande, provide a strong evidence for solar neutrino flavor transformation (3.3σ). The deduced total solar neutrino flux is in good agreement with standard solar model predictions. No significant distortion in the energy spectrum is observed

  10. Results from VENUS

    International Nuclear Information System (INIS)

    Ogawa, K.

    1990-01-01

    Recent results from VENUS experiments on e + e - reactions at energies between 52 and 60.8 GeV are presented. The R-values, the ratio of the total hadronic cross section to that of μ pair production, look slightly high within the present energy region. To understand this observation, a detailed study was carried out on the production of a heavy quark with |Q|=e/3. By using a next-to-leading log. approximation, the QCD cut-off parameter, Λ MS , was obtained as being Λ MS =208 MeV(+80MeV, -62MeV). The differential cross sections for e + e - → e + e - , γγ, μ + μ - , and τ + τ - were found to be consistent with predictions of the standard model. The average charge asymmetry for e + e - → qq-bar was also measured and found to be consistent with the prediction of the standard model. No evidence was observed indicating new particle production. No single photon production was observed and the upper limit of the number of light neutrino types was set to be N ν < 17.8 (90 % CL). (author)

  11. Results from SNO

    Energy Technology Data Exchange (ETDEWEB)

    Chan, Yuen-dat

    2001-10-01

    The Sudbury Neutrino Observatory (SNO) is an underground heavy water Cherenkov detector for studying solar neutrinos. SNO is capable of performing both flavor sensitive and flavor blind measurements of the solar neutrino flux. The first charged current (CC) measurement is found to be: {psi}{sub SNO}{sup CC}({nu}{sub e}) = 1.75 {+-} 0.07(stat.){sub -0.11}{sup +0.12}(sys.) {+-} 0.05 (theor.) x 10{sup 6} cm{sup -2}s{sup -1} and the elastic scattering fluxes (ES) is: {psi}{sub SNO}{sup ES}({nu}{sub x}) = 2.39 {+-} 0.34(stat.){sub -0.14}{sup +0.16} (sys.) x 10{sup 6} cm{sup -2}s{sup -1}. The {psi}{sub SNO}{sup CC}({nu}{sub e}) result, when combined with the high statistics elastic scattering (ES) measurement from Super-Kamiokande, provide a strong evidence for solar neutrino flavor transformation (3.3{sigma}). The deduced total solar neutrino flux is in good agreement with standard solar model predictions. No significant distortion in the energy spectrum is observed.

  12. Overview of MAGIC results

    Science.gov (United States)

    Rico, Javier; MAGIC Collaboration

    2016-04-01

    MAGIC is a system of two 17-m diameter Cherenkov telescopes, located at the Observatorio del Roque de los Muchachos, in the Canary island La Palma (Spain). MAGIC performs astronomical observations of gamma-ray sources in the energy range between 50 GeV and 10 TeV. The first MAGIC telescope has been operating since 2004, and in 2009 the system was completed with the second one. During 2011 and 2012 the electronics for the readout system were fully upgraded, and the camera of the first telescope replaced. After that, no major hardware interventions are foreseen in the next years, and the experiment has undertaken a final period of steady astronomical observations. MAGIC studies particle acceleration in the most violent cosmic environments, such as active galactic nuclei, gamma-ray bursts, pulsars, supernova remnants or binary systems. In addition, it addresses some fundamental questions of Physics, such as the origin of Galactic cosmic rays and the nature of dark matter. Moreover, by observing the gamma-ray emission from sources at cosmological distances, we measure the intensity and evolution of the extragalactic background radiation, and perform tests of Lorentz Invariance. In this paper I present the status and some of the latest results of the MAGIC gamma-ray telescopes.

  13. Results from LHCf Experiment

    CERN Document Server

    Tricomi, Alessia

    2012-01-01

    The LHCf experiment has taken data in 2009 and 2010 p-p collisions at LHC at $\\sqrt{s} = 0.9$ TeV and $\\sqrt{s} = 7$ TeV. The measurement of the forward neutral particle spectra produced in proton-proton collisions at LHC up to an energy of 14 TeV in the center of mass system are of fundamental importance to calibrate the Monte Carlo models widely used in the high energy cosmic ray (HECR) field, up to an equivalent laboratory energy of the order of $10^{17}$ eV. In this paper the first results on the inclusive photon spectrum measured by LHCf is reported. Comparison of this spectrum with the model expectations show significant discrepancies, mainly in the high energy region. In addition, perspectives for future analyses as well as the program for the next data taking period, in particular the possibility to take data in p-Pb collisions, will be discussed.

  14. Climax granite test results

    Energy Technology Data Exchange (ETDEWEB)

    Ramspott, L.D.

    1980-01-15

    The Lawrence Livermore Laboratory (LLL), as part of the Nevada Nuclear Waste Storage Investigations (NNWSI) program, is carrying out in situ rock mechanics testing in the Climax granitic stock at the Nevada Test Site (NTS). This summary addresses only those field data taken to date that address thermomechanical modeling for a hard-rock repository. The results to be discussed include thermal measurements in a heater test that was conducted from October 1977 through July 1978, and stress and displacement measurements made during and after excavation of the canister storage drift for the Spent Fuel Test (SFT) in the Climax granite. Associated laboratory and field measurements are summarized. The rock temperature for a given applied heat load at a point in time and space can be adequately modeled with simple analytic calculations involving superposition and integration of numerous point source solutions. The input, for locations beyond about a meter from the source, can be a constant thermal conductivity and diffusivity. The value of thermal conductivity required to match the field data is as much as 25% different from laboratory-measured values. Therefore, unless we come to understand the mechanisms for this difference, a simple in situ test will be required to obtain a value for final repository design. Some sensitivity calculations have shown that the temperature field is about ten times more sensitive to conductivity than to diffusivity under the test conditions. The orthogonal array was designed to detect anisotropy. After considering all error sources, anisotropic efforts in the thermal field were less than 5 to 10%.

  15. Areva: 2014 annual results

    International Nuclear Information System (INIS)

    Repaire, Philippine du

    2015-01-01

    The scale of the net loss for 2014 illustrates the twofold challenge confronting AREVA: continuing stagnation of the nuclear operations, lack of competitiveness and difficulties in managing the risks inherent in large projects. The group understands how serious this situation is. A comprehensive strategic review of operations was undertaken beginning in November 2014 and is being carried out without compromise. As a result, AREVA is now able to announce a solid transformation plan that sets a challenging but economically realistic course for its teams. First, AREVA will refocus on its core business: mastery of key nuclear processes essential to operators around the globe. This strategic redeployment will lead to the revision of certain goals, whether in the management of new reactor projects or in renewable energies. AREVA's objective is to achieve excellence as a high value-added supplier of products and services. Secondly, AREVA, whose resources had been marshaled to support a spurt of growth in nuclear power, must now adapt to new market realities and become competitive once again. The group's most urgent task is recovery and securing its future by immediately launching a far-reaching competitiveness plan founded on organizational simplification, quality of operations, and a completely revamped approach to managing risk in large projects. Last but not least, AREVA must ensure sustainable financing for its activities. A financing plan will be clarified before publication of the half-year financial statements. This document presents the key financial data of the group, its strategic road-map and its operating and financing plans

  16. PDX experimental results

    International Nuclear Information System (INIS)

    Meade, D.; Arunasalam, V.; Barnes, C.

    1981-01-01

    During the initial period of operation PDX has obtained the following results: (a) Production of macroscopically stable poloidal divertor configurations with dee, inverse-dee and single null plasma shapes. (b) Determined vertical positional instability growth rates for passively stabilized elongated dee-shaped plasmas with surface elongations from 1 to 1.4. (c) Production of Z approximately equal to 1 plasmas in a diverted dee configuration with confinement times approaching 80 ms for plasmas with Isub(p) approximately equal to 300 kA, Bsub(T)=17 kG, a=38 cm, q approximately equal to 3 and anti nsub(e) approximately equal to 4x10 13 cm -3 . (d) Extended the Ohmic heating regime to q approximately equal to 2 at nsub(e)R/Bsub(T) approximately equal to 10 15 cm -2 T -1 and q approximately equal to 3 at anti nsub(e)R/Bsub(T) approximately equal to 4.5x10 15 cm -2 T -1 . Neutral beam injection has extended anti nsub(e)R/Bsub(T) to approximately 6x10 15 cm -2 T -1 . (e) Initial neutral beam injection experiments with 1-2 MW injected perpendicularly have been used to study ion and electron heating with divertor control of density and impurities. (f) Divertor physics studies indicate that the divertor captures approximately 70% of the input power, while approximately 30% of the power is radiated. (g) Particle and energy flow onto the divertor neutralizer plate is in qualitative agreement with a simple sheath model. (author)

  17. AREVA annual results 2009

    International Nuclear Information System (INIS)

    2009-01-01

    AREVA expanded its backlog and increased its revenues compared with 2008, on strong installed base business and dynamic major projects, fostering growth in operating income of 240 million euros. As announced previously, Areva is implementing a financing plan suited to its objectives of profitable growth. The plan was implemented successfully in 2009, including the conclusion of an agreement, under very satisfactory terms, to sell its Transmission and Distribution business for 4 billion euros, asset sales for more than 1.5 billion euros, and successful bond issues of 3 billion euros. The plan will continue in 2010 with a capital increase, the completion of asset disposals and cost reduction and continued operational performance improvement programs. Areva bolstered its Renewable Energies business segment by supplementing its offshore wind power and biomass businesses with the acquisition of Ausra, a California-based leader in concentrated solar power technology. Despite the sale of T and D, Areva is maintaining its financial performance outlook for 2012: 12% average annual revenue growth to 12 billion euros in 2012, double digit operating margin and substantially positive free operating cash flow. Annual results 2009: - For the group as a whole, including Transmission and Distribution: Backlog: euros 49.4 bn (+2.5%), Revenues: euros 14 bn (+6.4%), Operating income: euros 501 m (+20.1%); - Nuclear and Renewable Energies perimeter: Backlog: euros 43.3 bn (+1.8%), Strong revenue growth: +5.4% to euros 8.5 bn, Operating income before provision for the Finnish project in the first half of 2009: euros 647 m, Operating income: euros 97 m, for a euros 240 m increase from 2008; - Net income attributable to equity holders of the parent: euros 552 m, i.e. euros 15.59 per share; - Net debt: euros 6,193 m; - Pro-forma net debt, including net cash to be received from the sale of T and D in 2010: euros 3,022 m; - Dividend of euros 7.06 per share to be proposed during the Annual

  18. Overview of MAST results

    International Nuclear Information System (INIS)

    Counsell, G.F.; Akers, R.J.; Appel, L.C.

    2005-01-01

    field. Early edge localized mode activity on MAST is associated with the formation of narrow filamentary structures following field lines in the edge. These filaments rotate toroidally with the edge plasma and, away from the X-points, accelerate radially outwards from the edge up to 20 cm. Studies of disruptions on MAST demonstrate a complex evolution of core energy loss and resultant divertor power loads, including phases where the target heat flux width is broadened by a factor of 8. Observations of energetic particle modes driven by super-Alfvenic beam ions provide support for a model for the non-linear evolution of toroidal Alfven eigenmodes (AEs) forming Bernstein-Green-Krushal waves. The AE activity reduces to low levels with increasing β. Plasma start-up without a central solenoid and in a manner compatible with future large spherical tokamak (ST) devices has been demonstrated using breakdown at a quadrupole magnetic null. Closed flux surface plasmas with peak plasma currents up to 370 kA have been generated and sustained for 0.3 s. New error field correction coils have extended the operational space for low density plasmas and enabled scaling studies of error field induced locked mode formation in the ST

  19. Overview of MAST results

    International Nuclear Information System (INIS)

    Counsell, G.F.; Akers, R.J.; Appel, L.C.

    2005-01-01

    filamentary structures following field lines in the edge. These filaments rotate toroidally with the edge plasma and, away from the X-points, accelerate radially outwards from the edge up to 20cm. Studies of disruptions on MAST demonstrate a complex evolution of core energy loss and resultant divertor power loads, including phases where the target heat flux width is broadened by a factor 8. Observations of energetic particle modes driven by super-Alfvenic beam ions provide support for a model for the non-linear evolution of toroidal Alfven eigenmodes (AE) forming BGK waves. AE activity reduces to low levels with increasing β. Plasma start-up without a central solenoid and in a manner compatible with future large ST devices has been demonstrated using breakdown at a quadrupole magnetic null. Closed flux surface plasmas with peak plasma currents up to 370 kA have been generated and sustained for 0.3s. New error field correction coils have extended the operational space for low density plasmas and enabled scaling studies of error field induced locked mode formation in the ST. (author)

  20. Promising pesticide results

    International Nuclear Information System (INIS)

    Wallace, Paula

    2012-01-01

    of DDT in soil. Given its 'sticky' quality, DDT is difficult to isolate and treat in the solid matrix of soil. “Our ViroFlow Technology has been designed to overcome both these problems by using a chemical, not bacterial, agent and by separating DDT from the structure of the soil matrix, thereby making it vulnerable to decomposition,” said Barros. As a result of these findings, Virotec is conducting a series of tests in conjunction with the NSW EPA and Department of Primary Industries to examine ways its solution can be applied to treating DDT in soil.

  1. Result

    Indian Academy of Sciences (India)

    With reference to the detailed evaluation of bids submitted the following agencies has been selected to award the contract on L1 ( lowest bidder) basis. 1. M/s . CITO INFOTECH, Bengaluru ( for procurement of desktop computers). 2. M/s. MCCANNINFO SOLUTION, Mumbai ( for procurement of laptops computers)

  2. Result

    African Journals Online (AJOL)

    Tsinuel

    BACKGROUND: Neonatal deaths in general, early neonatal deaths in particular now represent two- third of infant deaths and one-third of under-five deaths worldwide. Therefore, improving newborn survival is a major priority in child health today. Negotiation of improved neonatal health care practice into the community ...

  3. Actin and myosin contribute to mammalian mitochondrial DNA maintenance

    Science.gov (United States)

    Reyes, A.; He, J.; Mao, C. C.; Bailey, L. J.; Di Re, M.; Sembongi, H.; Kazak, L.; Dzionek, K.; Holmes, J. B.; Cluett, T. J.; Harbour, M. E.; Fearnley, I. M.; Crouch, R. J.; Conti, M. A.; Adelstein, R. S.; Walker, J. E.; Holt, I. J.

    2011-01-01

    Mitochondrial DNA maintenance and segregation are dependent on the actin cytoskeleton in budding yeast. We found two cytoskeletal proteins among six proteins tightly associated with rat liver mitochondrial DNA: non-muscle myosin heavy chain IIA and β-actin. In human cells, transient gene silencing of MYH9 (encoding non-muscle myosin heavy chain IIA), or the closely related MYH10 gene (encoding non-muscle myosin heavy chain IIB), altered the topology and increased the copy number of mitochondrial DNA; and the latter effect was enhanced when both genes were targeted simultaneously. In contrast, genetic ablation of non-muscle myosin IIB was associated with a 60% decrease in mitochondrial DNA copy number in mouse embryonic fibroblasts, compared to control cells. Gene silencing of β-actin also affected mitochondrial DNA copy number and organization. Protease-protection experiments and iodixanol gradient analysis suggest some β-actin and non-muscle myosin heavy chain IIA reside within human mitochondria and confirm that they are associated with mitochondrial DNA. Collectively, these results strongly implicate the actomyosin cytoskeleton in mammalian mitochondrial DNA maintenance. PMID:21398640

  4. Pulsed Ultraviolet Light Reduces Immunoglobulin E Binding to Atlantic White Shrimp (Litopenaeus setiferus Extract

    Directory of Open Access Journals (Sweden)

    Si-Yin Chung

    2011-06-01

    Full Text Available Pulsed ultraviolet light (PUV, a novel food processing and preservation technology, has been shown to reduce allergen levels in peanut and soybean samples. In this study, the efficacy of using PUV to reduce the reactivity of the major shrimp allergen, tropomyosin (36-kDa, and to attenuate immunoglobulin E (IgE binding to shrimp extract was examined. Atlantic white shrimp (Litopenaeus setiferus extract was treated with PUV (3 pulses/s, 10 cm from light source for 4 min. Tropomyosin was compared in the untreated, boiled, PUV-treated and [boiled+PUV]-treated samples, and changes in the tropomyosin levels were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE. IgE binding of the treated extract was analyzed via immunoblot and enzyme-linked immunosorbent assay (ELISA using pooled human plasma containing IgE antibodies against shrimp allergens. Results showed that levels of tropomyosin and IgE binding were reduced following PUV treatment. However, boiling increased IgE binding, while PUV treatment could offset the increased allergen reactivity caused by boiling. In conclusion, PUV treatment reduced the reactivity of the major shrimp allergen, tropomyosin, and decreased the IgE binding capacity of the shrimp extract.

  5. A novel alpha-tropomyosin mutation associates with dilated and non-compaction cardiomyopathy and diminishes actin binding

    NARCIS (Netherlands)

    van de Meerakker, Judith B. A.; Christiaans, Imke; Barnett, Phil; Lekanne Deprez, Ronald H.; Ilgun, Aho; Mook, Olaf R. F.; Mannens, Marcel M. A. M.; Lam, Jan; Wilde, Arthur A. M.; Moorman, Antoon F. M.; Postma, Alex V.

    2013-01-01

    Dilated cardiomyopathy (DCM) is characterized by idiopathic dilatation and systolic contractile dysfunction of the ventricle(s) leading to an impaired systolic function. The origin of DCM is heterogeneous, but genetic transmission of the disease accounts for up to 50% of the cases. Mutations in

  6. Gene expression signatures predict outcome in non-muscle invasive bladder carcinoma - a multi-center validation study

    DEFF Research Database (Denmark)

    Andersen, Lars Dyrskjøt; Zieger, Karsten; Real, Francisco X.

    2007-01-01

    and carcinoma in situ (CIS) and for predicting disease recurrence and progression. EXPERIMENTAL DESIGN: We analyzed tumors from 404 patients diagnosed with bladder cancer in hospitals in Denmark, Sweden, England, Spain, and France using custom microarrays. Molecular classifications were compared with pathologic....... CONCLUSION: This multicenter validation study confirms in an independent series the clinical utility of molecular classifiers to predict the outcome of patients initially diagnosed with non-muscle-invasive bladder cancer. This information may be useful to better guide patient treatment....

  7. Interleukin-6 markedly decreases skeletal muscle protein turnover and increases nonmuscle amino acid utilization in healthy individuals

    DEFF Research Database (Denmark)

    van Hall, Gerrit; Steensberg, Adam; Fischer, Christian

    2008-01-01

    CONTEXT: IL-6 is a key modulator of immune function and suggested to be involved in skeletal muscle wasting as seen in sepsis. OBJECTIVE: Our objective was to determine the role of IL-6 in human in vivo systemic and skeletal muscle amino acid metabolism and protein turnover. SUBJECTS AND METHODS...... synthesis was more suppressed than breakdown, causing a small increase in net muscle protein breakdown. Furthermore, rhIL-6 decreased arterial amino acid concentration with 20-40%, despite the increase net release from muscle. CONCLUSIONS: We demonstrated that IL-6 profoundly alters amino acid turnover....... A substantial decrease in plasma amino acids was observed with a concomitant 50% decrease in muscle protein turnover, however, modest increase in net muscle degradation. We hypothesize that the profound reduction in muscle protein turnover and modest increase in net degradation are primarily caused...

  8. LHC physics results and prospects

    CERN Document Server

    Kono, Takanori; The ATLAS collaboration

    2018-01-01

    This talk presents the latest results from LHC Run-2 as of May 2018 which include Standard Model measurements, Higgs boson properties and beyond Standard Model search results. The prospects for future LHC runs are also shown.

  9. Recent SUSY Results from CMS

    CERN Multimedia

    CERN. Geneva

    2012-01-01

    We present a summary of the recent results of searches for supersymmetry conducted by the CMS experiment. Several searches are reported using complementary final states and methods. The results presented include searches for stops and sbottoms, production of charginos and neutralinos, and R-parity violating signatures. Several of them are the first results of their kind from CMS, while others increased the mass reach significantly over previously published results from the LHC.

  10. An overview of JET results

    International Nuclear Information System (INIS)

    Adams, J.M.; Alladio, F.; Altmann, H.

    1989-01-01

    An overview is given of experimental results obtained on JET during 1988, and in particular of results at high total power input into plasmas with various configurations. An account is given of the various interpretations of these results and some of the difficulties encountered are related. The progress is summarised in terms of the projected D-T performance. (author)

  11. Aesthetic rhinoplasty: Avoiding unfavourable results

    Directory of Open Access Journals (Sweden)

    Kulwant S Bhangoo

    2013-01-01

    Full Text Available Rhinoplasty is one of the most challenging surgical procedures in plastic surgery. It is not surprising that a significant number of patients end up with unfavourable outcomes. Many of these unfavourable outcomes could be the result of poor judgment and wrong decision making. Most frequently, the unfavourable outcome is the result of errors in surgical technique. In this paper, unfavourable outcomes resulting from errors in surgical technique are discussed under the heading of each operative step. Poor placement of intra-nasal incision can result in internal valve obstruction. Bad columellar scars can result from errors during open rhinoplasty. Unfavourable results associated with skeletonisation are mentioned. Tip plasty, being the most difficult part of rhinoplasty, can result in lack of tip projection, asymmetry and deformities associated with placement of tip grafts. Over-resection of the lower lateral cartilages during tip plasty can also result in pinched nose, alar collapse causing external valve obstruction and other alar rim deformities. Humpectomy can result in open roof deformity, inverted V deformity and over-resection resulting in saddle nose. The so-called poly beak deformity is also a preventable unfavourable outcome when dealing with a large dorsal hump. Complications resulting from osteotomies include narrowing of nasal airway, open roof deformity, inverted V deformity and asymmetry of the bony wall resulting from incomplete or green stick fractures. Judicious use of grafts can be very rewarding. By the same token, grafts also carry with them the risk of complications. Allografts can result in recurrent infection, atrophy of the overlying skin and extrusion resulting in crippling deformities. Autografts are recommended by the author. Unfavourable results from autografts include displacement of graft, visibility of the graft edges, asymmetry, warping, and resorption.

  12. Solar neutrino results from SAGE

    International Nuclear Information System (INIS)

    Gavrin, V.N.

    2001-01-01

    The results of ten years of solar neutrino observation by the Russian-American gallium solar neutrino experiment (SAGE) are reported. The overall result of 70 runs during the measurement period from January 1990 to October 1999 is 75.4 -6.8 +7.0 (stat.) -3.0 +3.5 (syst) SNU. This represents only slightly more than half of the predicted standard solar model rate of 129 SNU. The individual results on each run, and the results of combined analysis of all runs during each year, as well as the results of combined analysis of all runs during monthly and bimonthly periods are presented

  13. Solar neutrino results from SAGE

    International Nuclear Information System (INIS)

    Gavrin, V.N.

    2000-01-01

    We report the results of ten years of solar neutrino observation by the Russian-American Gallium solar neutrino Experiment (SAGE). The overall result of 70 runs during the measurement period January 1990 to October 1999 is 75.4 + 7.0/-6.8 (stat.) +3.5/-3.0 (syst.) SNU. This represents only slightly more than half of the predicted standard solar model rate of 129 SNU. The individual results of each run, and the results of combined analysis of all runs during each year, as well as the results of combined analysis of all runs during monthly and bimonthly periods are presented

  14. CCTF CORE I test results

    International Nuclear Information System (INIS)

    Murao, Yoshio; Sudoh, Takashi; Akimoto, Hajime; Iguchi, Tadashi; Sugimoto, Jun; Fujiki, Kazuo; Hirano, Kenmei

    1982-07-01

    This report presents the results of the following CCTF CORE I tests conducted in FY. 1980. (1) Multi-dimensional effect test, (2) Evaluation model test, (3) FLECHT coupling test. On the first test, one-dimensional treatment of the core thermohydrodynamics was discussed. On the second and third tests, the test results were compared with the results calculated by the evaluation model codes and the results of the corresponding FLECHT-SET test (Run 2714B), respectively. The work was performed under contracts with the Atomic Energy Bureau of Science and Technology Agency of Japan. (author)

  15. New results from NA49

    CERN Document Server

    Afanasiev, S V; Bächler, J; Barna, D; Barnby, L S; Bartke, Jerzy; Barton, R A; Behler, M; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Blyth, C O; Boimska, B; Botje, M; Bracinik, J; Brady, F P; Bramm, R; Brun, R; Buncic, P; Carr, L; Cebra, D; Cerny, V; Cooper, G E; Cramer, J G; Csató, P; Dinkelaker, P; Eckardt, V; Eckhardt, F; Ferenc, D; Filip, P; Fischer, H G; Foder, Z; Foka, P Y; Freund, P; Friese, V; Gál, J; Ganz, R E; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Harris, J W; Hegyi, S; Höhne, C; Igo, G; Jacobs, P; Jones, P G; Kadija, K; Kolesnikov, V I; Kollegger, T; Kowalski, M; Kraus, I; Kreps, M; Lasiuk, B; Van Leeuwen, M; Lévai, Peter; Malakhov, A I; Margetis, S; Markert, C; Mayes, B W; Melkumov, G L; Mischke, A; Molnár, J; Nelson, J M; Odyniec, Grazyna Janina; Oldenburg, M; Pálla, G; Panagiotou, A D; Perl, K; Petridis, A; Pikna, M; Pinsky, L; Poskanzer, A M; Prindle, D J; Pühlhofer, F; Putschke, J; Reid, J G; Renfordt, A; Retyk, W; Ritter, H G; Röhrich, D; Roland, C; Roland, G; Rybicki, A; Sammer, T; Sann, H; Schäfer, E; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Snellings, R; Squier, G T A; Stock, Reinhard; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Toy, M; Trainor, T A; Trentalange, S; Ullrich, T S; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Voloshin, S A; Vranic, D; Wang, F; Weerasundara, D D; Wenig, S; Wetzler, A; Whitten, C; Xu, N; Yates, T A; Koo, I K; Zaranek, J; Zimányi, J

    2002-01-01

    Recent results of the NA49 experiment are presented. These cover first results on pion and kaon production, HBT, and charge fluctuations from Pb+Pb reactions at 40 AGeV and their comparison to 158 AGeV beam energy. Furthermore a study on baryon number transfer in p+p, centrality selected p+Pb and Pb+Pb collisions at 158 AGeV and new results on the system size dependence of kaon yields, including C+C and Si+Si data, are presented. Additionally, a first result on Lambda Lambda correlations is shown. (11 refs).

  16. Retirement Applicant Satisfaction Survey Results

    Data.gov (United States)

    Social Security Administration — This dataset contains information about the Retirement Applicant Survey (RAS). The survey measured satisfaction results with the retirement application process. The...

  17. Recent physics results from LEP

    International Nuclear Information System (INIS)

    Augustin, J.E.

    1990-12-01

    The LEP machine operations, the recent observation of transverse beam polarization, and the luminosity measurements are summarized. The results obtained up to now on the tests of the electroweak sector of the Standard Model are reviewed. This includes the Z neutral boson excitation curve parameters in hadronic and leptonic modes, the forward-backward asymmetries of the leptons, the detection of the polarization of the taus, and the corresponding results on the number of light neutrinos, on the electroweak coupling constants and mixing angle, and on the top quark mass. Some hadronic physics results and QCD studies are reported. The results for particle searches, notably the Higgs boson are summarized

  18. Heavy ion results from ATLAS

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00241915; The ATLAS collaboration

    2017-01-01

    These proceedings provide an overview of the new results obtained with the ATLAS Detector at the LHC, which are presented in the Quark Matter 2017 conference. These results are covered in twelve parallel talks, one flash talk and eleven posters, and they are grouped into five areas: initial state, jet quenching, quarkonium production, longitudinal flow dynamics, and collectivity in small systems.

  19. FORWARD PHYSICS AND BRAHMS RESULTS.

    Energy Technology Data Exchange (ETDEWEB)

    DEBBE, R.; (FOR THE BRAHMS COLLABORATION)

    2005-02-03

    We report here the BRAHMS measurements of particle production in d+Au and p+p collisions at RHIC. The results presented here are compared to previous p+A measurements at lower energies in fixed target mode. Some preliminary results on abundances of identified particles at high rapidity are also presented.

  20. Possible distortion of autoradiographic results

    Energy Technology Data Exchange (ETDEWEB)

    Kozlov, A.A.; Tumanushvili, G.D. (AN Gruzinskoj SSR, Tbilisi. Inst. Ehksperimental' noj Morfologii)

    1980-01-01

    The effect of radioactive labelling (H/sup 3/-thymidine) on the infusorian division is studied. The presented results show that introduction of labelled compounds results in accelerating infusorian cell division v. Thorough investigation of labelled compound effect with low activity on the parameters of cell division and the search of methods to eliminate distortions able to appear in autoradiographic experiments is expedient.

  1. CDF results on B decays

    International Nuclear Information System (INIS)

    Skarha, J.E.

    1995-05-01

    The authors present recent CDF results on B lifetimes, B meson mass measurements, ratios of branching ratios, and rare decays. In addition, they present the first measurement of time-dependent B d mixing at CDF. Several results have been updated and a few new ones included since the workshop

  2. RESULTS, RESPONSIBILITY, FAULT AND CONTROL

    Directory of Open Access Journals (Sweden)

    Evgeniy Stoyanov

    2016-09-01

    Full Text Available The paper focuses on the responsibility arising from the registered financial results. The analysis of this responsibility presupposes its evaluation and determination of the role of fault in the formation of negative results. The search for efficiency in this whole process is justified by the understanding of the mechanisms that regulate the behavior of economic actors.

  3. First neutron results from SNS

    International Nuclear Information System (INIS)

    Leadbetter, A.J.; Abbley, D.; Bailey, I.F.

    1985-05-01

    The report summarises the analyses of the first neutron results on the pulsed spallation source SNS. The source parameters; aspects of the instrumentation; and experimental results particular to a given beamline; are all discussed. General conclusions based on these data, the detectors and the computing system, are also examined. (U.K.)

  4. Graphical presentation of participants' results

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    The results obtained by 19 participating dosimetry systems are presented in this section. Section 3 of the preceding report, ''Evaluation of the Results of the First IAEA Coordinated Research Program on Intercomparison for Individual Monitoring'', explains the format and conventions used for the graphical presentation. The system number appearing in the upper left hand corner of each page can be used to correlate the dosimeter design information found in Table 2 of the preceding report with the results. However, care should be used in drawing inferences from this correlation, since system performance depends on a number of factors other than detector selection and design characteristics. (orig.)

  5. Customer interruption cost and results

    Energy Technology Data Exchange (ETDEWEB)

    Eua-Arporn, B.; Bisarnbutra, S. [Chulalongkorn Univ., Bangkok (Thailand)

    1997-12-31

    Results of a comprehensive study on short-term direct impacts and consumer interruption costs, incurred as a result of power supply interruption, were discussed. The emphasis was on questionnaire development, general responses and the average customer damage function of some selected sectors. The customer damage function was established for each category of customers (agriculture, industry, mining, wholesale, retail merchandising, residential, etc) as well as for different locations. Results showed that the average customer damage function depended mostly on customer category. Size and location were not significant factors. 5 refs., 7 tabs.

  6. Solar neutrino results from SAGE

    International Nuclear Information System (INIS)

    Gavrin, V.N.

    1999-01-01

    We report the status of the Russian-American Gallium solar neutrino Experiment (SAGE). The solar neutrino result for SAGE III, 20 runs during the measuring period May 1995 through December 1997, is 56.7 +9.3/-8.7(stat.)+4.6/-4.8(syst.) SNU. The combined result for 57 measurements from 1990 through 1997 (SAGE I+II+III) is 66.9 +7.1/-6.8 (stat) +5.4/-5.7 (syst) SNU. The final result of the SAGE 51 Cr experiment to check the response of SAGE to low energy neutrinos is also presented

  7. Cell emulation and preliminary results.

    Science.gov (United States)

    2016-07-01

    This report details preliminary results of the testing plan implemented by the Hawaii Natural Energy Institute to evaluate Electric Vehicle (EV) battery durability and reliability under electric utility grid operations. Commercial EV battery cells ar...

  8. New results from old spectroscopy

    International Nuclear Information System (INIS)

    Hemingway, R.J.

    1977-01-01

    A report is presented of some of the major experimental results during the last year in the field of old spectroscopy. Included are properties, quark model, multiplets, particle interactions, and cross sections. 34 references

  9. Electroweak results from the tevatron

    International Nuclear Information System (INIS)

    Wood, D.

    1997-01-01

    Electroweak results are presented from the CDF and DO experiments based on data collected in recent runs of the Fermilab Tevatron Collider. The measurements include the mass and width of the W boson, the production cross sections of the W and Z bosons, and the W charge asymmetry. Additional results come from studies of events with pairs of electroweak gauge bosons and include limits on anomalous couplings

  10. Electroweak results from the tevatron

    Energy Technology Data Exchange (ETDEWEB)

    Wood, D. [Fermi National Accelerator Laboratory, Batavia, IL (United States)

    1997-01-01

    Electroweak results are presented from the CDF and DO experiments based on data collected in recent runs of the Fermilab Tevatron Collider. The measurements include the mass and width of the W boson, the production cross sections of the W and Z bosons, and the W charge asymmetry. Additional results come from studies of events with pairs of electroweak gauge bosons and include limits on anomalous couplings.

  11. Consolidated results 2000. Forecasts 2001

    International Nuclear Information System (INIS)

    2001-01-01

    This document presents an economic analysis of the Group Gaz De France consolidated results for the year 2000. The main topics are the evolution of the energy market, the great economic growth for the five businesses of the Group (exploration-production, trade, transport, distribution and services), financial results affected by the supply costs increase, the position reinforcement among the gas leaders in Europe and the highlights of 2000. (A.L.B.)

  12. Planck 2013 results. I. Overview of products and scientific results

    CERN Document Server

    Ade, P.A.R.; Armitage-Caplan, C.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Baccigalupi, C.; Banday, A.J.; Barreiro, R.B.; Bartelmann, M.; Bartlett, J.G.; Battaner, E.; Benabed, K.; Benoit, A.; Benoit-Levy, A.; Bernard, J.P.; Bersanelli, M.; Bielewicz, P.; Bobin, J.; Bock, J.J.; Bonaldi, A.; Bond, J.R.; Borrill, J.; Bouchet, F.R.; Boulanger, F.; Bowyer, J.W.; Bridges, M.; Bucher, M.; Burigana, C.; Butler, R.C.; Cappellini, B.; Cardoso, J.F.; Carr, R.; Casale, M.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.R.; Chen, X.; Chiang, L.Y.; Chiang, H.C.; Christensen, P.R.; Church, S.; Clements, D.L.; Colombi, S.; Colombo, L.P.L.; Couchot, F.; Coulais, A.; Crill, B.P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R.D.; Davis, R.J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.M.; Desert, F.X.; Dickinson, C.; Diego, J.M.; Dole, H.; Donzelli, S.; Dore, O.; Douspis, M.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Ensslin, T.A.; Eriksen, H.K.; Falgarone, E.; Finelli, F.; Foley, S.; Forni, O.; Frailis, M.; Franceschi, E.; Freschi, M.; Fromenteau, S.; Gaier, T.C.; Galeotta, S.; Gallegos, J.; Gandolfo, B.; Ganga, K.; Giard, M.; Giardino, G.; Giraud-Heraud, Y.; Gonzalez-Nuevo, J.; Gorski, K.M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Haissinski, J.; Hansen, F.K.; Hanson, D.; Harrison, D.; Helou, G.; Henrot-Versille, S.; Hernandez-Monteagudo, C.; Herranz, D.; Hildebrandt, S.R.; Hivon, E.; Hobson, M.; Holmes, W.A.; Hornstrup, A.; Hovest, W.; Huffenberger, K.M.; Jaffe, T.R.; Jaffe, A.H.; Jewell, J.; Jones, W.C.; Juvela, M.; Kangaslahti, P.; Keihanen, E.; Keskitalo, R.; Kisner, T.S.; Kneissl, R.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lahteenmaki, A.; Lamarre, J.M.; Lasenby, A.; Laureijs, R.J.; Lawrence, C.R.; Le Jeune, M.; Leach, S.; Leahy, J.P.; Leonardi, R.; Leon-Tavares, J.; Leroy, C.; Lesgourgues, J.; Liguori, M.; Lilje, P.B.; Linden-Vornle, M.; Lopez-Caniego, M.; Lowe, S.; Lubin, P.M.; Macias-Perez, J.F.; Maffei, B.; Maino, D.; Mandolesi, N.; Maris, M.; Marshall, D.J.; Martin, P.G.; Martinez-Gonzalez, E.; Masi, S.; Matarrese, S.; Matthai, F.; Mazzotta, P.; McDonald, A.; McGehee, P.; Meinhold, P.R.; Melchiorri, A.; Melin, J.B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Miniscalco, R.; Mitra, S.; Miville-Deschenes, M.A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J.A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C.B.; Norgaard-Nielsen, H.U.; North, C.; Noviello, F.; Novikov, D.; Novikov, I.; O'Dwyer, I.J.; Osborne, S.; Oxborrow, C.A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Pearson, D.; Pearson, T.J.; Perdereau, O.; Perotto, L.; Perrotta, F.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Platania, P.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G.W.; Prezeau, G.; Prunet, S.; Puget, J.L.; Rachen, J.P.; Reach, W.T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ricciardi, S.; Riller, T.; Ringeval, C.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rowan-Robinson, M.; Rubino-Martin, J.A.; Rusholme, B.; Salerno, E.; Sandri, M.; Santos, D.; Savini, G.; Scott, D.; Seiffert, M.D.; Shellard, E.P.S.; Smoot, G.F.; Spencer, L.D.; Starck, J.L.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sureau, F.; Sutton, D.; Suur-Uski, A.S.; Sygnet, J.F.; Tauber, J.A.; Tavagnacco, D.; Taylor, D.; Terenzi, L.; Texier, D.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Turler, M.; Tuttlebee, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Varis, J.; Vibert, L.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L.A.; Wandelt, B.D.; Watson, R.; Watson, C.; White, M.; White, S.D.M.; Wilkinson, A.; Yvon, D.; Zacchei, A.; Zonca, A.

    2014-01-01

    The ESA's Planck satellite, dedicated to studying the early universe, was launched on May 2009 and has been surveying the microwave and submillimetre sky since August 2009. In March 2013, ESA and the Planck Collaboration publicly released the initial cosmology products based on the first 15.5 months of Planck operations, along with a set of scientific and technical papers and a web-based explanatory supplement. This paper describes the mission and its performance, and gives an overview of the processing and analysis of the data, the characteristics of the data, the main scientific results, and the science data products and papers in the release. Scientific results include robust support for the standard, six parameter LCDM model of cosmology and improved measurements for the parameters that define this model, including a highly significant deviation from scale invariance of the primordial power spectrum. The Planck values for some of these parameters and others derived from them are significantly different fr...

  13. Planck 2015 results: I. Overview of products and scientific results

    DEFF Research Database (Denmark)

    Adam, R.; Ade, P. A R; Aghanim, N.

    2016-01-01

    Collaboration released the second set of cosmology products based ondata from the entire Planck mission, including both temperature and polarization, along with a set of scientific and technical papers and a web-based explanatory supplement. This paper gives an overview of the main characteristics of the data...... and the data products in the release, as well as the associated cosmological and astrophysical science results and papers. The data products include maps of the cosmic microwave background (CMB), the thermal Sunyaev-Zeldovich effect, diffuse foregrounds in temperature and polarization, catalogues of compact...... against the Planck data is described, along with a CMB lensing likelihood. Scientific results include cosmological parameters derived from CMB power spectra, gravitational lensing, and cluster counts, as well as constraints on inflation, non-Gaussianity, primordial magnetic fields, dark energy...

  14. Planck 2013 results. I. Overview of products and scientific results

    DEFF Research Database (Denmark)

    Planck Collaboration,; Ade, P. A. R.; Aghanim, N.

    2013-01-01

    , and the science data products and papers in the release. Scientific results include robust support for the standard, six parameter LCDM model of cosmology and improved measurements for the parameters that define this model, including a highly significant deviation from scale invariance of the primordial power......The ESA's Planck satellite, dedicated to studying the early universe, was launched on May 2009 and has been surveying the microwave and submillimetre sky since August 2009. In March 2013, ESA and the Planck Collaboration publicly released the initial cosmology products based on the first 15.......5 months of Planck operations, along with a set of scientific and technical papers and a web-based explanatory supplement. This paper describes the mission and its performance, and gives an overview of the processing and analysis of the data, the characteristics of the data, the main scientific results...

  15. Automated, computer interpreted radioimmunoassay results

    International Nuclear Information System (INIS)

    Hill, J.C.; Nagle, C.E.; Dworkin, H.J.; Fink-Bennett, D.; Freitas, J.E.; Wetzel, R.; Sawyer, N.; Ferry, D.; Hershberger, D.

    1984-01-01

    90,000 Radioimmunoassay results have been interpreted and transcribed automatically using software developed for use on a Hewlett Packard Model 1000 mini-computer system with conventional dot matrix printers. The computer program correlates the results of a combination of assays, interprets them and prints a report ready for physician review and signature within minutes of completion of the assay. The authors designed and wrote a computer program to query their patient data base for radioassay laboratory results and to produce a computer generated interpretation of these results using an algorithm that produces normal and abnormal interpretives. Their laboratory assays 50,000 patient samples each year using 28 different radioassays. Of these 85% have been interpreted using our computer program. Allowances are made for drug and patient history and individualized reports are generated with regard to the patients age and sex. Finalization of reports is still subject to change by the nuclear physician at the time of final review. Automated, computerized interpretations have realized cost savings through reduced personnel and personnel time and provided uniformity of the interpretations among the five physicians. Prior to computerization of interpretations, all radioassay results had to be dictated and reviewed for signing by one of the resident or staff physicians. Turn around times for reports prior to the automated computer program generally were two to three days. Whereas, the computerized interpret system allows reports to generally be issued the day assays are completed

  16. Presentation of economic evaluation results.

    Science.gov (United States)

    Chaikledkaew, Usa

    2014-05-01

    The first HTA guidelines for Thailand included a chapter outlining a set of guidelines on how best to report the findings of health economic evaluations, based on a review of best practice and existing guidelines on the presentation of economic evaluation results from around the world. In this second edition of HTA guidelines for Thailand, the recommendations build on the first edition by using a case study to illustrate how the guidelines can be applied in a real research context. The guidelines propose that all reporting include ten key elements: defining the scope of the study, selection of comparator(s), defining the type of economic evaluation, measurement of costs, measurement of clinical effects, handling time in economic evaluation studies, handling uncertainty and sensitivity analysis, presentation of the results, discussion of the results, and disclosure of funding and authors conflict of interest.

  17. Recent results from hadron colliders

    International Nuclear Information System (INIS)

    Frisch, H.J.

    1990-01-01

    This is a summary of some of the many recent results from the CERN and Fermilab colliders, presented for an audience of nuclear, medium-energy, and elementary particle physicists. The topics are jets and QCD at very high energies, precision measurements of electroweak parameters, the remarkably heavy top quark, and new results on the detection of the large flux of B mesons produced at these machines. A summary and some comments on the bright prospects for the future of hadron colliders conclude the talk. 39 refs., 44 figs., 3 tabs

  18. First results from SAGE II

    International Nuclear Information System (INIS)

    Abdurashitov, J.N.; Faizov, E.L.; Gavrin, V.N.

    1994-01-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first five runs of SAGE II give a capture rate of 76 -18 +21 (stat) -7 +5 (sys) SNU. combined with the SAGE I result, the capture rate is 74 -12 +13 (stat) -7 +5 (sys) SNU. This represents only 56%--60% of the capture rate predicted by different Standard Solar Models

  19. Impossibility results for distributed computing

    CERN Document Server

    Attiya, Hagit

    2014-01-01

    To understand the power of distributed systems, it is necessary to understand their inherent limitations: what problems cannot be solved in particular systems, or without sufficient resources (such as time or space). This book presents key techniques for proving such impossibility results and applies them to a variety of different problems in a variety of different system models. Insights gained from these results are highlighted, aspects of a problem that make it difficult are isolated, features of an architecture that make it inadequate for solving certain problems efficiently are identified

  20. Turning Science Results into News

    Science.gov (United States)

    Wanjek, Christopher

    2006-09-01

    Do you want to get into the New York Times? Aside from writing an angry letter or robbing a bank, getting into the news (with your science result) requires a well-crafted press release. Reaching out to reporters is very different from reaching out to fellow scientists. Scientific significance is not the same as newsworthiness, but many science results can be molded into interesting stories that reporters can relate to their audience. This presentation will present examples of science stories that made it big and some that flopped. We will also examine what makes a story attractive to newspaper and magazine editors.

  1. Communicating Performance Assessments Results - 13609

    International Nuclear Information System (INIS)

    Layton, Mark

    2013-01-01

    The F-Area Tank Farms (FTF) and H-Area Tank Farm (HTF) are owned by the U.S. Department of Energy (DOE) and operated by Savannah River Remediation LLC (SRR), Liquid Waste Operations contractor at DOE's Savannah River Site (SRS). The FTF and HTF are active radioactive waste storage and treatment facilities consisting of 51 carbon steel waste tanks and ancillary equipment such as transfer lines, evaporators and pump tanks. Performance Assessments (PAs) for each Tank Farm have been prepared to support the eventual closure of the underground radioactive waste tanks and ancillary equipment. PAs provide the technical bases and results to be used in subsequent documents to demonstrate compliance with the pertinent requirements for final closure of the Tank Farms. The Tank Farms are subject to a number of regulatory requirements. The State regulates Tank Farm operations through an industrial waste water permit and through a Federal Facility Agreement approved by the State, DOE and the Environmental Protection Agency (EPA). Closure documentation will include State-approved Tank Farm Closure Plans and tank-specific closure modules utilizing information from the PAs. For this reason, the State of South Carolina and the EPA must be involved in the performance assessment review process. The residual material remaining after tank cleaning is also subject to reclassification prior to closure via a waste determination pursuant to Section 3116 of the Ronald W. Reagan National Defense Authorization Act of Fiscal Year 2005. PAs are performance-based, risk-informed analyses of the fate and transport of FTF and HTF residual wastes following final closure of the Tank Farms. Since the PAs serve as the primary risk assessment tools in evaluating readiness for closure, it is vital that PA conclusions be communicated effectively. In the course of developing the FTF and HTF PAs, several lessons learned have emerged regarding communicating PA results. When communicating PA results it is

  2. Experimental results surprise quantum theory

    International Nuclear Information System (INIS)

    White, C.

    1986-01-01

    Interest in results from Darmstadt that positron-electron pairs are created in nuclei with high atomic numbers (in the Z range from 180-188) lies in the occurrence of a quantized positron kinetic energy peak at 300. The results lend substance to the contention of Erich Bagge that the traditionally accepted symmetries in positron-electron emission do not exist and, therefore, there is no need to posit the existence of the neutrino. The search is on for the decay of a previously unknown boson to account for the findings, which also points to the need for a major revision in quantum theory. 1 figure

  3. First results from SAGE II

    International Nuclear Information System (INIS)

    Aburashitov, J.N.; Faizov, E.L.; Gavrin, V.N.; Gusev, A.O.; Kalikhov, A.V.; Knodel, T.V.; Knyshenko, I.I.; Kornoukhov, V.N.; Mirmov, I.N.; Pshukov, A.M.; Shalagin, A.M.; Shikhin, A.A.; Timofeyev, P.V.; Veretenkin, E.P.; Vermul, V.M.; Zatsepin, G.T.; Bowles, T.J.; Nico, J.S.; Teasdale, W.A.; Wark, D.L.; Wilkerson, J.F.; Cleveland, B.T.; Daily, T.; Davis, R. Jr.; Lande, K.; Lee, C.K.; Wildenhain, P.W.; Elliott, S.R.; Cherry, M.L.

    1995-01-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first five runs of SAGE II give a capture rate of 76 +21 -18 (stat) +5 -7 (sys) SNU. Combined with the SAGE I result, the capture rate is 74 +13 -12 (stat) +5 -7 (sys) SNU. This represents only 56%--60% of the capture rate predicted by different Standard Solar Models. copyright 1995 American Institute of Physics

  4. Results from Numerical General Relativity

    Science.gov (United States)

    Baker, John G.

    2011-01-01

    For several years numerical simulations have been revealing the details of general relativity's predictions for the dynamical interactions of merging black holes. I will review what has been learned of the rich phenomenology of these mergers and the resulting gravitational wave signatures. These wave forms provide a potentially observable record of the powerful astronomical events, a central target of gravitational wave astronomy. Asymmetric radiation can produce a thrust on the system which may accelerate the single black hole resulting from the merger to high relative velocity.

  5. Recent Results from the Tevatron

    International Nuclear Information System (INIS)

    Demorden, L.

    1998-06-01

    We review recent results from fixed-target and collider experiments at the Fermilab Tevatron. Among the topics discussed are jet production rates, α S measurements, the anti d/anti u ratio in the proton sea, diffraction, heavy quark physics and leptoquark searches

  6. New ATLAS Higgs physics results

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    New Higgs physics results from the ATLAS experiment using the full Run-1 LHC dataset, corresponding to an integrated luminosity of approximately 25 fb-1, of proton-proton collisions at 7 TeV and 8 TeV, will be presented.

  7. FFTF startup: status and results

    International Nuclear Information System (INIS)

    Noordhoff, B.H.; Moore, C.E.

    1980-03-01

    Startup testing on the Fast Flux Test Facility (FFTF) during the past three years has progressed beyond initial criticality toward the principal goal of power demonstration in 1980. An overview is presented of technical results to date and project plans to achieve power demonstration and complete the startup test program

  8. Recent results on howard's algorithm

    DEFF Research Database (Denmark)

    Miltersen, P.B.

    2012-01-01

    is generally recognized as fast in practice, until recently, its worst case time complexity was poorly understood. However, a surge of results since 2009 has led us to a much more satisfactory understanding of the worst case time complexity of the algorithm in the various settings in which it applies...

  9. Latest results from EXO-200

    International Nuclear Information System (INIS)

    TOSI, D.

    2014-01-01

    The Enriched Xenon Observatory (EXO) is an experimental program searching for neutrino-less double beta decay in xenon-136. The first stage of this program, EXO-200, has been in operation since early 2011. I present here the latest physics results from the experiment.

  10. LHCb time-dependent results

    OpenAIRE

    Calvi, Marta

    2011-01-01

    This review reports preliminary results of time-dependent measurements of decays of $B^0$ mesons and $B^0_s$ mesons coming from the analysis of about 36 pb$^{-1}$ of data collected by the LHCb experiment during the 2010 run of the Large Hadron Collider at $\\sqrt{s}$ = 7 TeV.

  11. LHCb time-dependent results

    OpenAIRE

    Calvi, Marta; Collaboration, for the LHCb

    2011-01-01

    This review reports preliminary results of time-dependent measurements of decays of B^0 mesons and B^0_s mesons coming from the analysis of about 36 pb^-1 of data collected by the LHCb experiment during the 2010 run of the Large Hadron Collider at sqrt(s)=7 TeV.

  12. Report of scientific results 1977

    International Nuclear Information System (INIS)

    1977-01-01

    The scientific progress report of the HMI for 1977 gives a survey of the main results of HMI research in the fields of neutron scattering, radiation damage in solids, reactor chemistry, trace element research in biomedicine, geochemistry, reactor operation, and radionuclide production. After this, short summaries are given of HMI publications and papers in the above fields. (HK) [de

  13. STANFORD (SLAC): Precision electroweak result

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    Precision testing of the electroweak sector of the Standard Model has intensified with the recent publication* of results from the SLD collaboration's 1993 run on the Stanford Linear Collider, SLC. Using a highly polarized electron beam colliding with an unpolarized positron beam, SLD physicists measured the left-right asymmetry at the Z boson resonance with dramatically improved accuracy over 1992

  14. HADES results in elementary reactions

    Directory of Open Access Journals (Sweden)

    Ramstein B.

    2014-01-01

    Full Text Available Recent results obtained with the HADES experimental set-up at GSI are presented with a focus on dielectron production and strangeness in pp and quasi-free np reactions. Perspectives related to the very recent experiment using the pion beam at GSI are also discussed.

  15. Latest results from B factories

    CERN Document Server

    Ben Haim, Eli

    2015-01-01

    I will briefly review recent results from Babar and Belle. For example, I will discuss probes for new physics in radiative penguin decays and the CP asymmetry in B0-B0bar mixing. I will also discuss direct searches for new physics, such as a light Higgs resonance or long lived particles.

  16. Electroweak results from hadron colliders

    International Nuclear Information System (INIS)

    Demarteau, Marcel

    1997-01-01

    A review of recent electroweak results from hadron colliders is given. Properties of the W ± and Z 0 gauge bosons using final states containing electrons and muons based on large integrated luminosities are presented. The emphasis is placed on the measurement of the mass of the W boson and the measurement of trilinear gauge boson couplings

  17. Juridical utilization of dosimetric results

    International Nuclear Information System (INIS)

    Hebert, J.

    1976-01-01

    The problems of the legal use of the results of dosimetry, for the solution of an action for instance, are considered first with respect to civil and occasionally administrative third part liability law making a distinction between common law and the special regime of civil liability for nuclear damage, secondly with respect to social security law [fr

  18. Recent results from DORIS II

    International Nuclear Information System (INIS)

    Bloom, E.D.

    1985-01-01

    This report contains a brief review of recent results from the ARGUS and Crystal Ball experiments at DORIS II, concentrating on UPSILON(1S) and UPSILON(2S) spectroscopy with a short foray into γγ physics. 18 refs., 10 figs

  19. CMS results on soft diffraction

    CERN Document Server

    INSPIRE-00086121

    2013-01-01

    We present measurements of soft single- and double-diffractive cross sections, as well as of forward rapidity gap cross sections at 7 TeV at the LHC, and compare the results to other measurements and to theoretical predictions implemented in various Monte Carlo simulations.

  20. Experimental results obtained at GANIL

    International Nuclear Information System (INIS)

    Borrel, V.

    1993-01-01

    A review of experimental results obtained at GANIL on the study of nuclear structure and nuclear reactions with secondary radioactive beams is presented. Mass measurements by means of the GANIL cyclotrons are described. The possibilities of GANIL/LISE3 for the production and separation of radioactive beams are illustrated through a large variety of experiments. (author). 19 refs., 8 figs

  1. Complexity Results in Epistemic Planning

    DEFF Research Database (Denmark)

    Bolander, Thomas; Jensen, Martin Holm; Schwarzentruber, Francois

    2015-01-01

    Epistemic planning is a very expressive framework that extends automated planning by the incorporation of dynamic epistemic logic (DEL). We provide complexity results on the plan existence problem for multi-agent planning tasks, focusing on purely epistemic actions with propositional preconditions...

  2. Stability of Global Geodetic Results

    Science.gov (United States)

    Herring, T.

    The precision of global geodetic techniques has reached unprecedented levels. Sys- tems capable of millimeter level horizontal and several millimeter vertical precisions are now deployed. The Global Positioning System (GPS) has the most deployed continuously-operating receivers with several hundred providing data through the in- ternet for analysis. However, the satellite system used with GPS evolves with time as new generations of GPS satellites are launched. During the 1990's, the constellation evolved from Block I to Block II and IIA with the most recent generation being Block IIR. There are considerable differences in the size and antenna configurations in the different generations of satellites. The antenna configuration specifically could cause systematic changes in the terrestrial reference system. Results from the ITRF2000 combinations suggest that there are significant time variations in the scale of GPS system possibly due to phase center variations in GPS transmission antennas. These variations could result in height changes of up to 3 mm/yr. We will investigate the stability of the GPS system through combination of GPS results with results from VLBI and SLR. All components of the transformation between the systems, rotation, translation and scale will be investigated.

  3. Recent results in strangeonium spectroscopy

    International Nuclear Information System (INIS)

    Aston, D.; Awaji, N.; Bienz, T.

    1988-10-01

    Data from exclusive s/bar s/ meson final states are shown. The data were obtained in a 4.1 ev/nb exposure of K - p interactions at 11 GeV/c in the LASS spectrometer at SLAC. The results from the analyses of these data is presented and the spectrum of strangeonium states is discussed. 8 refs., 8 figs

  4. New results from cosmic rays

    Energy Technology Data Exchange (ETDEWEB)

    Tonwar, S. C.

    1980-07-01

    Behavior of elementary particles at very high energies and new phenomena observed are discussed in the light of results obtained by cosmic ray studies. Methods of determining hadron-nucleus inelastic cross-sections are described. Proton energy spectra are studied at 2000-50,000 GeV and the hadron-proton total cross section is deduced. Measurement of the cross-section by measurement of the intensity of transition radiation is described. The instrumental effects and the corrections effected are mentioned. The results obtained by different groups of investigators are compared. Observations on the scaling violation at high energies are reported. New particles or phenomena observed include: (i) the long flying component (ii) centauro events, (iii) delayed particles (iv) high energy cascades in underground experiments and (v) charm hadron production in hadron collisions. New experiments being planned for further research are mentioned.

  5. First Physics Results from ALICE

    International Nuclear Information System (INIS)

    Peressounko, Dmitri; Castillo Castellanos, Javier; Belikov, Iouri

    2010-01-01

    ALICE is the LHC experiment dedicated to the study of heavy-ion collisions. The main purpose of ALICE is to investigate the properties of a state of deconfined nuclear matter, the Quark Gluon Plasma. Heavy flavour measurements will play a crucial role in this investigation. The physics programme of ALICE has started by studying proton-proton collisions at unprecedented high energies. We will present the first results on open heavy flavour and quarkonia in proton-proton collisions at √s = 7 TeV measured by the ALICE experiment at both mid- and forward-rapidities. We will conclude with the prospects for heavy flavour and quarkonium measurements in both proton-proton and nucleus-nucleus collisions. Also presented are first results of neutral meson reconstruction and its perspectives, as well as further physics studies. (author)

  6. Summary of CCTF test results

    International Nuclear Information System (INIS)

    Iguchi, T.; Murao, Y.; Sugimoto, J.; Akimoto, H.; Okubo, T.; Hojo, T.

    1987-01-01

    Conservatism of current safety analysis was assessed by comparing the predicted result with cylindrical core test facility (CCTF) test result performed at Japan Atomic Energy Research Institute. WREM code was selected for the assessment. The overall conservatism of the WREM code on the peak clad temperature prediction was confirmed against CCTF evaluation model (EM) test which simulated the typical initial and boundary conditions in the safety evaluation analysis. WREM code predicted the reasonable core boundary conditions and the conservatism of the code came mainly from core calculation. The conservatism of the WREM code against CCTF data could be attributed to the following three points: (1) no horizontal mixing assumption between subchannels at each elevation; (2) no modeling on heat transfer enhancement caused by the radial core power profile; and (3) conservative heat transfer correlations in the code

  7. Communicating Performance Assessments Results - 13609

    Energy Technology Data Exchange (ETDEWEB)

    Layton, Mark [Savannah River Remediation LLC, Building 705-1C, Aiken, SC 29808 (United States)

    2013-07-01

    The F-Area Tank Farms (FTF) and H-Area Tank Farm (HTF) are owned by the U.S. Department of Energy (DOE) and operated by Savannah River Remediation LLC (SRR), Liquid Waste Operations contractor at DOE's Savannah River Site (SRS). The FTF and HTF are active radioactive waste storage and treatment facilities consisting of 51 carbon steel waste tanks and ancillary equipment such as transfer lines, evaporators and pump tanks. Performance Assessments (PAs) for each Tank Farm have been prepared to support the eventual closure of the underground radioactive waste tanks and ancillary equipment. PAs provide the technical bases and results to be used in subsequent documents to demonstrate compliance with the pertinent requirements for final closure of the Tank Farms. The Tank Farms are subject to a number of regulatory requirements. The State regulates Tank Farm operations through an industrial waste water permit and through a Federal Facility Agreement approved by the State, DOE and the Environmental Protection Agency (EPA). Closure documentation will include State-approved Tank Farm Closure Plans and tank-specific closure modules utilizing information from the PAs. For this reason, the State of South Carolina and the EPA must be involved in the performance assessment review process. The residual material remaining after tank cleaning is also subject to reclassification prior to closure via a waste determination pursuant to Section 3116 of the Ronald W. Reagan National Defense Authorization Act of Fiscal Year 2005. PAs are performance-based, risk-informed analyses of the fate and transport of FTF and HTF residual wastes following final closure of the Tank Farms. Since the PAs serve as the primary risk assessment tools in evaluating readiness for closure, it is vital that PA conclusions be communicated effectively. In the course of developing the FTF and HTF PAs, several lessons learned have emerged regarding communicating PA results. When communicating PA results it is

  8. PREVAIL: latest electron optics results

    Science.gov (United States)

    Pfeiffer, Hans C.; Golladay, Steven D.; Gordon, Michael S.; Kendall, Rodney A.; Lieberman, Jon E.; Rockrohr, James D.; Stickel, Werner; Yamaguchi, Takeshi; Okamoto, Kazuya; Umemoto, Takaaki; Shimizu, Hiroyasu; Kojima, Shinichi; Hamashima, Muneki

    2002-07-01

    The PREVAIL electron optics subsystem developed by IBM has been installed at Nikon's facility in Kumagaya, Japan, for integration into the Nikon commercial EPL stepper. The cornerstone of the electron optics design is the Curvilinear Variable Axis Lens (CVAL) technique originally demonstrated with a proof of concept system. This paper presents the latest experimental results obtained with the electron optical subsystem at Nikon's facility. The results include micrographs illustrating proper CVAL operation through the spatial resolution achieved over the entire optical field of view. They also include data on the most critical issue of the EPL exposure approach: subfield stitching. The methodology of distortion correction will be described and both micrographs and metrology data of stitched subfields will be presented. This paper represents a progress report of the IBM/Nikon alliance activity on EPL.

  9. CMS results on multijet correlations

    CERN Document Server

    INSPIRE-00008500

    2015-04-10

    We present recent measurements of multijet correlations using forward and low-$p_{\\mathrm{T}}$ jets performed by the CMS collaboration at the LHC collider. In pp collisions at $\\sqrt{s} = 7$ TeV, azimuthal correlations in dijets separated in rapidity by up to 9.4 units were measured. The results are compared to BFKL- and DGLAP-based Monte Carlo generator and analytic predictions. In pp collisions at $\\sqrt{s} = 8$ TeV, cross sections for jets with $p_{\\mathrm{T}}$ > 21 GeV and |y| 1 GeV (minijets) are presented. The minijet results are sensitive to the bound imposed by the total inelastic cross section, and are compared to various models for taming the growth of the $2 \\rightarrow 2$ cross section at low $p_{\\mathrm{T}}$.

  10. Forget about data, deliver results

    Science.gov (United States)

    Walter, Roland

    2015-12-01

    High-energy astrophysics space missions have pioneered and demonstrated the power of legacy data sets for generating new discoveries, especially when analysed in ways original researchers could not have anticipated. The only way to ensure that the data of present observatories can be effectively used in the future is to allow users to perform on-the-fly data analysis to produce straightforwardly scientific results for any sky position, time and energy intervals without requiring mission specific software or detailed instrumental knowledge. Providing a straightforward interface to complex data and data analysis makes the data and the process of generating science results available to the public and higher education and promotes the visibility of the investment in science to the society. This is a fundamental step to transmit the values of science and to evolve towards a knowledge society.

  11. Analytical results for Abelian projection

    International Nuclear Information System (INIS)

    Ogilivie, Michael C.

    1999-01-01

    Analytic methods for Abelian projection are developed, and a number of results related to string tension measurements are obtained. It is proven that even without gauge fixing, Abelian projection yields string tensions of the underlying non-Abelian theory. Strong arguments are given for similar results in the case where gauge fixing is employed. The subgroup used for projection need only contain the center of the gauge group, and need not be Abelian. While gauge fixing is shown to be in principle unnecessary for the success of Abelian projection, it is computationally advantageous for the same reasons that improved operators, e.g., the use of fat links, are advantageous in Wilson loop measurements

  12. Marshland study brings fruitful results

    Energy Technology Data Exchange (ETDEWEB)

    1978-03-01

    There are approximately 110,000 square kilometers of marshland in China containing peat and other valuable resources. The results of a marshland study have been presented as a chapter in a book titled Physical Geography of China. In 1970, the Kirin Normal University established an experimental plant for the utilization of peat. Four kinds of peat fertilizers produced by this plant have been used with good results at 20 communes in Kirin Province. Four kinds of construction materials (peat board, peat tiles, peat insulation bricks and peat insulation tubes) were also successfully made. A certain type of peat can be used as fuel to heat malt in the process of whiskey making. New applications of peat have been found in medicine, water purification, and in the manufacturing of electrodes for condensers.

  13. Results on light quark spectroscopy

    International Nuclear Information System (INIS)

    Bienlein, J.K.; Harjes, J.; Kolanoski, H.

    1991-12-01

    This report contains a survey article of resonance production by the Crystal Ball Collaboration from J. K. Bienlein, an article on CELLO results for γγΠ*p* +- - from J. Harjes, a survey article on the production of scalar and tensor mesons in two-photon collisions, and an article on the study of the a 1 resonance by τ decays, the last two articles are both from H. Kolanoski. See hints under the relevant topics. (HSI)

  14. Interatom results for stage 2

    International Nuclear Information System (INIS)

    Coors, D.

    1990-01-01

    This report contains the Interatom results for Stage 2 of the ''IWGFR Programme on Intercomparison of LMFBR Core Mechanics Codes'' which was agreed upon on a Consultants Meeting in Vienna, 8-10 December, 1987. The calculations were performed with the 3D core mechanics code system DDT developed at Interatom and with the 2D core mechanics code FIAT. (author). 5 refs, 11 figs, 8 tabs

  15. Supersymmetry results at the Tevatron

    International Nuclear Information System (INIS)

    Badaud, Frederique

    2007-01-01

    The results for searches for Supersymmetry by the CDF and D0 collaborations in pp-bar collisions at √s=1.96 TeV are presented here. Searches for chargino/neutralino and the lightest stop, as well as scenarios with R-parity violation are focused here. The integrated luminosity analyzed ranges from 300 to 800 pb -1 depending on the search. Further informations can be found on the public web pages of the two experiments. (author)

  16. Recent results from Daya Bay

    Directory of Open Access Journals (Sweden)

    Chua Ming-chung

    2016-01-01

    Full Text Available Utilizing powerful nuclear reactors as antineutrino sources, high mountains to provide ample shielding from cosmic rays in the vicinity, and functionally identical detectors with large target volume for near-far relative measurement, the Daya Bay Reactor Neutrino Experiment has achieved unprecedented precision in measuring the neutrino mixing angle θ13 and the neutrino mass squared difference |Δm2ee|. I will report the latest Daya Bay results on neutrino oscillations and light sterile neutrino search.

  17. Recent DIII-D results

    International Nuclear Information System (INIS)

    Petersen, P.I.

    1994-07-01

    This paper summarizes the recent DIII-D experimental results and the development of the relevant hardware systems. The DIII-D program focuses on divertor solutions for next generation tokamaks such as International Thermo-nuclear Experimental Reactor (ITER) and Tokamak Physics Experiment (TPX), and on developing configurations with enhanced confinement and stability properties that will lead to a more compact and economical fusion reactor. The DIII-D program carries out this research in an integrated fashion

  18. Results from the FDIRC prototype

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, D.A., E-mail: roberts@umd.edu [University of Maryland, College Park, MD 20742 (United States); Arnaud, N. [Laboratoire de l’Accélérateur Linéaire, Centre Scientifique d’Orsay, F-91898 Orsay Cedex (France); Dey, B. [University of California, Riverside, CA 92521 (United States); Borsato, M. [Laboratoire de l’Accélérateur Linéaire, Centre Scientifique d’Orsay, F-91898 Orsay Cedex (France); Leith, D.W.G.S.; Nishimura, K.; Ratcliff, B.N. [SLAC, Stanford University, Palo Alto, CA 94309 (United States); Varner, G. [University of Hawaii, Honolulu, HI 96822 (United States); Va’vra, J. [SLAC, Stanford University, Palo Alto, CA 94309 (United States)

    2014-12-01

    We present results from a novel Cherenkov imaging detector called the Focusing DIRC (FDIRC). This detector was designed as a prototype of the particle identification system for the SuperB experiment, and comprises 1/12 of the SuperB barrel azimuthal coverage with partial electronics implementation. The prototype was tested in the SLAC Cosmic Ray Telescope (CRT) which provides 3-D muon tracking with an angular resolution of ∼1.5 mrad, track position resolution of 5–6 mm, start time resolution of 70 ps, and a muon low-energy cutoff of ∼2 GeV provided by an iron range stack. The quartz focusing photon camera couples to a full-size BaBar DIRC bar box and is read out by 12 Hamamatsu H8500 MaPMTs providing 768 pixels. We used IRS2 waveform digitizing electronics to read out the MaPMTs. We present several results from our on-going development activities that demonstrate that the new optics design works very well, including: (a) single photon Cherenkov angle resolutions with and without chromatic corrections, (b) S/N ratio between the Cherenkov peak and background, which consists primarily of ambiguities in possible photon paths to a given pixel, (c) dTOP=TOP{sub measured}–TOP{sub expected} resolutions, and (d) performance of the detector in the presence of high-rate backgrounds. We also describe data analysis methods and point out limits of the present performance. - Highlights: • We present results from a novel Cherenkov imaging detector called the Focusing DIRC (FDIRC). • The prototype was tested in the SLAC Cosmic Ray Telescope (CRT) which provides 3-D muon tracking. • We present several results from our on-going development activities that demonstrate that new optics design works very well. • We describe data analysis methods and point out limits of the present performance.

  19. Results of recent LOFT experiments

    International Nuclear Information System (INIS)

    Leach, L.P.; Hanson, D.J.; Batt, D.L.

    1982-01-01

    Five experiments were performed in the Loss-of-Fluid Test (LOFT) facility during the past year. The experiments conducted spanned a wide range of potential accident scenarios, including large and small break loss-of-coolant accidents (LOCAs), control rod withdrawal accidents, uncontrolled boron dilution, and anticipated transients without scram (ATWS). This summary describes these experiments and presents results available from the experiments and experiment prediction calculations. A brief overview is given for the remaining experiment planned in the LOFT Program

  20. CMS results on hard diffraction

    CERN Document Server

    INSPIRE-00107098

    2013-01-01

    In these proceedings we present CMS results on hard diffraction. Diffractive dijet production in pp collisions at $\\sqrt{s}$=7 TeV is discussed. The cross section for dijet production is presented as a function of $\\tilde{\\xi}$, representing the fractional momentum loss of the scattered proton in single-diffractive events. The observation of W and Z boson production in events with a large pseudo-rapidity gap is also presented.

  1. First half 2006 financial results

    International Nuclear Information System (INIS)

    2006-09-01

    Areva provides technological solutions for highly reliable nuclear power generation and electricity transmission and distribution. The group is the world leader in nuclear power and the only company to cover all industrial activities in this field. This Press release presents the first half 2006 financial results: the overall performance and the performance by division (front end, reactors and services, back end, transmission and distribution). (A.L.B.)

  2. LHC Results Highlights (CLASHEP 2013)

    CERN Document Server

    Gonzalez, O.

    2015-05-22

    The good performance of the LHC provided enough data at 7 TeV and 8 TeV to allow the experiments to perform very competitive measurements and to expand the knowledge about the fundamental interaction far beyond that from previous colliders. This report summarizes the highlights of the results obtained with these data samples by the four large experiments, covering all the topics of the physics program and focusing on those exploiting the possibilities of the LHC.

  3. Energy conservation. Ambitions and results

    International Nuclear Information System (INIS)

    2011-01-01

    From results of monitoring it is shown that energy conservation in the Netherlands is behind the ambitions of the Dutch government. The Dutch Court of Audit examined the reasons why energy conservation targets are not met and what the consequences are for the national and European energy and climate goals for 2020. Also the Dutch Court of Audit looked at the possibilities to make energy saving policies more effective. [nl

  4. Presentation of RTE results 2003

    International Nuclear Information System (INIS)

    2004-01-01

    For RTE, the financial year 2003 was marked by a number of achievements: our financial performances registered a clear improvement, above objectives, with turnover growing strongly; net income reached levels almost three times higher than those recorded in 2002; the economic rate of return rose to 7.1%; and debt was reduced by 470 Meuros. These results are explained by the substantial improvement in productivity, which has risen by 5% per year on average over the last three years

  5. SPQR - Spectroscopy: Prospects, Questions & Results

    Science.gov (United States)

    Pennington, M. R.

    2014-06-01

    Tremendous progress has been made in mapping out the spectrum of hadrons over the past decade with plans to make further advances in the decade ahead. Baryons and mesons, both expected and unexpected, have been found, the results of precision experiments often with polarized beams, polarized targets and sometimes polarization of the final states. All these hadrons generate poles in the complex energy plane that are consequences of the strong coupling regime of QCD. They reveal how this works.

  6. Audit result and its users

    Directory of Open Access Journals (Sweden)

    Shalimova Nataliya S.

    2014-01-01

    Full Text Available The article identifies essence of the “audit result” and “users of audit result” notions and characteristics of the key audit results user. It shows that in order to give a wide characteristic of users it is expedient to unite all objects, which could be used (audit report, fact of refusal to conduct audit and information that is submitted to managers in the process of audit with the term “audit result” and classify it depending on the terms of submission by final and intermediate result. The article offers to define audit results user as a person, persons or category of persons for whom the auditor prepares the audit report and, in cases, envisaged by international standards of the audit and domestic legislative and regulatory acts, provides other additional information concerning audit issues. In order to identify the key audit results user the article distributes all audit tasks into two groups depending on possibilities of identification of users. The article proves that the key user should be identified especially in cases of a mandatory audit and this process should go in interconnection with the mechanism of allocation of a key user of financial reports. It offers to consider external users with direct financial interests, who cannot request economic subjects directly to provide information and who should rely on general financial reports and audit report when receiving significant portion of information they need, as the key user. The article makes proposals on specification of the categorical mechanism in the sphere of audit, which are the basis for audit quality assessment, identification of possibilities and conditions of appearance of the necessary and sufficient trust to the auditor opinion.

  7. Analysis of Benchmark 2 results

    International Nuclear Information System (INIS)

    Bacha, F.; Lefievre, B.; Maillard, J.; Silva, J.

    1994-01-01

    The code GEANT315 has been compared to different codes in two benchmarks. We analyze its performances through our results, especially in the thick target case. In spite of gaps in nucleus-nucleus interaction theories at intermediate energies, benchmarks allow possible improvements of physical models used in our codes. Thereafter, a scheme of radioactive waste burning system is studied. (authors). 4 refs., 7 figs., 1 tab

  8. Physics results from polarized DIS

    International Nuclear Information System (INIS)

    Ramsey, G. P.

    1998-01-01

    We have extracted polarized nucleon distributions from recent data at CERN, SLAC and DESY. The flavor-dependent valence and sea quark spin distributions are determined for each experiment. We take into account possible differences in the up and down sea distributions, and assume that the strange sea contribution is suppressed by mass effects. Physics results determined from different experiments are compared, including higher order corrections

  9. Physics results from polarized DIS.

    Energy Technology Data Exchange (ETDEWEB)

    Ramsey, G. P.

    1998-03-23

    We have extracted polarized nucleon distributions from recent data at CERN, SLAC and DESY. The flavor-dependent valence and sea quark spin distributions are determined for each experiment. We take into account possible differences in the up and down sea distributions, and assume that the strange sea contribution is suppressed by mass effects. Physics results determined from different experiments are compared, including higher order corrections.

  10. Result-Based Public Governance

    DEFF Research Database (Denmark)

    Boll, Karen

    Within the public sector, many institutions are either steered by governance by targets or result-based governance. The former sets up quantitative internal production targets, while the latter advocates that production is planned according to outcomes which are defined as institution-produced ef......Within the public sector, many institutions are either steered by governance by targets or result-based governance. The former sets up quantitative internal production targets, while the latter advocates that production is planned according to outcomes which are defined as institution......-produced effects on individuals or businesses in society; effects which are often produced by ‘nudging’ the citizenry in a certain direction. With point of departure in these two governance-systems, the paper explores a case of controversial inspection of businesses’ negative VAT accounts and it describes...... explores how and why this state of affairs appears and problematizes the widespread use of result-based governance and nudging-techniques by public sector institutions....

  11. Presentation of the results 97

    International Nuclear Information System (INIS)

    1998-01-01

    Gaz de France (GDF) presents in a press kit the main results achieved in 1997. The European community has formulated a project of definition of rules concerning the natural gas market. Minima values for annual consumptions have been defined and the consumption and use of natural gas in EC countries is described. The financial results of GDF in 1997 are compared with previous years. Net sales grew by nearly 1 billion french francs to reach 55 billion. Overall sales were down by 4% but the share of natural gas in french energy consumption increased and sales to industrial users went up in particular due to new cogeneration plants installed in 1996. A comparison of gas prices in Europe is given for the years 1985 to 1998. The efforts of GDF to offer increased quality of services concerning in particular safety aspects as checking programs and installation of new safeguard appliances are described. The efforts of GDF to increase the energy market share of natural gas resulted in the development of new products like cogeneration, air conditioning and fuels for automotive needs. (C.B.)

  12. Presentation of RTE results 2003

    International Nuclear Information System (INIS)

    2003-01-01

    In 2003, RTE recorded a clear improvement in its financial results, and continued its debt reduction programme. The financial year 2003 was marked by a clear improvement in RTE's financial performance: results exceeded objectives, with turnover growing strongly, net income reached levels almost three times higher than those recorded in 2002, the economic rate of return rose to 7.1%, and debt was reduced by 470 Meuros. These results are explained by the substantial improvement in productivity, which has risen by 5% per year on average over the last three years. Net income has almost tripled due to RTE's improved productivity completed by a significant rise in its turnover and stabilizing operating costs RTE's finances therefore remain healthy, enabling the company to continue its debt reduction programme. Satisfactory economic and financial rates of return. Deadlines facing RTE in 2004: in application of the second European Directive, adopted on 26 June 2003, RTE faces two major deadlines in 2004: - the implementation of the 2. phase in the process of opening up the French electricity market, - its legal independence. On 1 July 2004, the market will be opened up to competition for all professional customers. At that date RTE, like all other electricity transmission system operators (TSOs) in the European Union, should be a legally independent body. The new central role of TSOs in Europe: how are electricity transmission system operators in other EU countries organised?

  13. Results Evaluation in Reduction Rhinoplasty

    Directory of Open Access Journals (Sweden)

    Arima, Lisandra Megumi

    2011-01-01

    Full Text Available Introduction: Final results evaluation after rhinoplasty is a not a topic widely studied from the patient's viewpoint. Objective:Evaluate the satisfaction of the patients submitted to reduction rhinoplasty, from the questionnaire Rhinoplasty Outcomes Evaluation (ROE. Method: Longitudinal study, retrospective cut type, of the preoperative and postoperative satisfaction. The sample was composed by 28 patients who were submitted to rhinoplasty and answered the ROE questionnaire. Three variables were obtained: satisfaction note that the patient had with his/her image before the surgery; note of satisfaction with the current appearance; the difference of the average satisfaction notes between postoperative and preoperative approaches. Results: The postoperative note was higher than the preoperative in all patients. We noticed a difference between the average of the postoperative and preoperative of 48.3 (p75 considered to be an excellent outcome (67.9%. Conclusions: The ROE questionnaire is a helpful tool to show the satisfaction of the patient submitted to reduction rhinoplasty. About 92% of the patients submitted to reduction rhinoplasty consider the postoperative result to be good or excellent.

  14. Planck 2015 results. I. Overview of products and scientific results

    CERN Document Server

    Adam, R.; Aghanim, N.; Akrami, Y.; Alves, M.I.R.; Arnaud, M.; Arroja, F.; Aumont, J.; Baccigalupi, C.; Ballardini, M.; Banday, A.J.; Barreiro, R.B.; Bartlett, J.G.; Bartolo, N.; Basak, S.; Battaglia, P.; Battaner, E.; Battye, R.; Benabed, K.; Benoit, A.; Benoit-Levy, A.; Bernard, J.P.; Bersanelli, M.; Bertincourt, B.; Bielewicz, P.; Bonaldi, A.; Bonavera, L.; Bond, J.R.; Borrill, J.; Bouchet, F.R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R.C.; Calabrese, E.; Cardoso, J.F.; Carvalho, P.; Casaponsa, B.; Castex, G.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.R.; Chiang, H.C.; Chluba, J.; Christensen, P.R.; Church, S.; Clemens, M.; Clements, D.L.; Colombi, S.; Colombo, L.P.L.; Combet, C.; Comis, B.; Contreras, D.; Couchot, F.; Coulais, A.; Crill, B.P.; Cruz, M.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R.D.; Davis, R.J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.M.; Desert, F.X.; Di Valentino, E.; Dickinson, C.; Diego, J.M.; Dolag, K.; Dole, H.; Donzelli, S.; Dore, O.; Douspis, M.; Ducout, A.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Eisenhardt, P.R.M.; Elsner, F.; Ensslin, T.A.; Eriksen, H.K.; Falgarone, E.; Fantaye, Y.; Farhang, M.; Feeney, S.; Fergusson, J.; Fernandez-Cobos, R.; Feroz, F.; Finelli, F.; Florido, E.; Forni, O.; Frailis, M.; Fraisse, A.A.; Franceschet, C.; Franceschi, E.; Frejsel, A.; Frolov, A.; Galeotta, S.; Galli, S.; Ganga, K.; Gauthier, C.; Genova-Santos, R.T.; Gerbino, M.; Ghosh, T.; Giard, M.; Giraud-Heraud, Y.; Giusarma, E.; Gjerlow, E.; Gonzalez-Nuevo, J.; Gorski, K.M.; Grainge, K.J.B.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J.E.; Hamann, J.; Handley, W.; Hansen, F.K.; Hanson, D.; Harrison, D.L.; Heavens, A.; Helou, G.; Henrot-Versille, S.; Hernandez-Monteagudo, C.; Herranz, D.; Hildebrandt, S.R.; Hivon, E.; Hobson, M.; Holmes, W.A.; Hornstrup, A.; Hovest, W.; Huang, Z.; Huffenberger, K.M.; Hurier, G.; Ilic, S.; Jaffe, A.H.; Jaffe, T.R.; Jin, T.; Jones, W.C.; Juvela, M.; Karakci, A.; Keihanen, E.; Keskitalo, R.; Kiiveri, K.; Kim, J.; Kisner, T.S.; Kneissl, R.; Knoche, J.; Krachmalnicoff, N.; Kunz, M.; Kurki-Suonio, H.; Lacasa, F.; Lagache, G.; Lahteenmaki, A.; Lamarre, J.M.; Langer, M.; Lasenby, A.; Lattanzi, M.; Lawrence, C.R.; Le Jeune, M.; Leahy, J.P.; Lellouch, E.; Leonardi, R.; Leon-Tavares, J.; Lesgourgues, J.; Levrier, F.; Lewis, A.; Liguori, M.; Lilje, P.B.; Linden-Vornle, M.; Lindholm, V.; Liu, H.; Lopez-Caniego, M.; Lubin, P.M.; Ma, Y.Z.; Macias-Perez, J.F.; Maggio, G.; Mak, D.S.Y.; Mandolesi, N.; Mangilli, A.; Marchini, A.; Marcos-Caballero, A.; Marinucci, D.; Marshall, D.J.; Martin, P.G.; Martinelli, M.; Martinez-Gonzalez, E.; Masi, S.; Matarrese, S.; Mazzotta, P.; McEwen, J.D.; McGehee, P.; Mei, S.; Meinhold, P.R.; Melchiorri, A.; Melin, J.B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mikkelsen, K.; Mitra, S.; Miville-Deschenes, M.A.; Molinari, D.; Moneti, A.; Montier, L.; Moreno, R.; Morgante, G.; Mortlock, D.; Moss, A.; Mottet, S.; Muenchmeyer, M.; Munshi, D.; Murphy, J.A.; Narimani, A.; Naselsky, P.; Nastasi, A.; Nati, F.; Natoli, P.; Negrello, M.; Netterfield, C.B.; Norgaard-Nielsen, H.U.; Noviello, F.; Novikov, D.; Novikov, I.; Olamaie, M.; Oppermann, N.; Orlando, E.; Oxborrow, C.A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Pandolfi, S.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Pearson, T.J.; Peel, M.; Peiris, H.V.; Pelkonen, V.M.; Perdereau, O.; Perotto, L.; Perrott, Y.C.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pogosyan, D.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G.W.; Prezeau, G.; Prunet, S.; Puget, J.L.; Rachen, J.P.; Racine, B.; Reach, W.T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Roman, M.; Romelli, E.; Rosset, C.; Rossetti, M.; Rotti, A.; Roudier, G.; d'Orfeuil, B.Rouille; Rowan-Robinson, M.; Rubino-Martin, J.A.; Ruiz-Granados, B.; Rumsey, C.; Rusholme, B.; Said, N.; Salvatelli, V.; Salvati, L.; Sandri, M.; Sanghera, H.S.; Santos, D.; Saunders, R.D.E.; Sauve, A.; Savelainen, M.; Savini, G.; Schaefer, B.M.; Schammel, M.P.; Scott, D.; Seiffert, M.D.; Serra, P.; Shellard, E.P.S.; Shimwell, T.W.; Shiraishi, M.; Smith, K.; Souradeep, T.; Spencer, L.D.; Spinelli, M.; Stanford, S.A.; Stern, D.; Stolyarov, V.; Stompor, R.; Strong, A.W.; Sudiwala, R.; Sunyaev, R.; Sutter, P.; Sutton, D.; Suur-Uski, A.S.; Sygnet, J.F.; Tauber, J.A.; Tavagnacco, D.; Terenzi, L.; Texier, D.; Toffolatti, L.; Tomasi, M.; Tornikoski, M.; Tristram, M.; Troja, A.; Trombetti, T.; Tucci, M.; Tuovinen, J.; Turler, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vassallo, T.; Vidal, M.; Viel, M.; Vielva, P.; Villa, F.; Wade, L.A.; Walter, B.; Wandelt, B.D.; Watson, R.; Wehus, I.K.; Welikala, N.; Weller, J.; White, M.; White, S.D.M.; Wilkinson, A.; Yvon, D.; Zacchei, A.; Zibin, J.P.; Zonca, A.

    2016-01-01

    The European Space Agency's Planck satellite, dedicated to studying the early Universe and its subsequent evolution, was launched 14~May 2009 and scanned the microwave and submillimetre sky continuously between 12~August 2009 and 23~October 2013. In February~2015, ESA and the Planck Collaboration released the second set of cosmology products based on data from the entire Planck mission, including both temperature and polarization, along with a set of scientific and technical papers and a web-based explanatory supplement. This paper gives an overview of the main characteristics of the data and the data products in the release, as well as the associated cosmological and astrophysical science results and papers. The science products include maps of the cosmic microwave background (CMB), the thermal Sunyaev-Zeldovich effect, and diffuse foregrounds in temperature and polarization, catalogues of compact Galactic and extragalactic sources (including separate catalogues of Sunyaev-Zeldovich clusters and Galactic col...

  15. Overview of the FTU results

    International Nuclear Information System (INIS)

    Alladio, F.; Angelini, B.; Apicella, M.L.

    1999-01-01

    An overview of the Frascati Tokamak Upgrade results during the period 1996-1998 is presented. Most of the activity has been devoted to the investigation of the electron heat transport with flat/nonmonotonic safety factor profiles. Up to 14 keV of electron temperature have been obtained using electron cyclotron resonance heating (ECRH) on the current ramp. The transport analysis shows a very low electron heat transport in the region with flat/nonmonotonic safety factor profile. The electron thermal conductivity is strongly dependent on the MHD activity and it drops to values of the order 0.1 m 2 /s in the absence of MHD fluctuations. Upon varying the resonance position in steady state conditions the effect of the ECRH on the sawtooth stabilization has been also investigated. Lower hybrid current drive studies have been performed in order to investigate the dependence of the current drive efficiency with density. Previous results of the Alcator C tokamak pointed out that at high density rather low efficiency values were obtained. The investigation carried out on FTU shows that such a result can be explained as due to the electron temperature dependence of the current drive efficiency. No degradation of the current drive efficiency is indeed observed on FTU even at density values of the order 10 20 m -3 . Ion Bernstein wave (IBW) heating studies have been also carried out in order to check the behaviour of wave-plasma coupling which is found in agreement with linear theory. Finally, impurity transport studies have been carried out. It has been possible to have a direct measurement of the flux of Mo33 which turns out to be in agreement with the expectation of quasilinear theory. (author)

  16. Visible nulling coronagraph testbed results

    Science.gov (United States)

    Lyon, Richard G.; Clampin, Mark; Woodruff, Robert A.; Vasudevan, Gopal; Thompson, Patrick; Petrone, Peter; Madison, Timothy; Rizzo, Maxime; Melnick, Gary; Tolls, Volker

    2009-08-01

    We report on our recent laboratory results with the NASA/Goddard Space Flight Center (GSFC) Visible Nulling Coronagraph (VNC) testbed. We have experimentally achieved focal plane contrasts of 1 x 108 and approaching 109 at inner working angles of 2 * wavelength/D and 4 * wavelength/D respectively where D is the aperture diameter. The result was obtained using a broadband source with a narrowband spectral filter of width 10 nm centered on 630 nm. To date this is the deepest nulling result with a visible nulling coronagraph yet obtained. Developed also is a Null Control Breadboard (NCB) to assess and quantify MEMS based segmented deformable mirror technology and develop and assess closed-loop null sensing and control algorithm performance from both the pupil and focal planes. We have demonstrated closed-loop control at 27 Hz in the laboratory environment. Efforts are underway to first bring the contrast to > 109 necessary for the direct detection and characterization of jovian (Jupiter-like) and then to > 1010 necessary for terrestrial (Earth-like) exosolar planets. Short term advancements are expected to both broaden the spectral passband from 10 nm to 100 nm and to increase both the long-term stability to > 2 hours and the extent of the null out to a ~ 10 * wavelength / D via the use of MEMS based segmented deformable mirror technology, a coherent fiber bundle, achromatic phase shifters, all in a vacuum chamber at the GSFC VNC facility. Additionally an extreme stability textbook sized compact VNC is under development.

  17. Overview of recent ALICE results

    Energy Technology Data Exchange (ETDEWEB)

    Gunji, Taku

    2016-12-15

    The ALICE experiment explores the properties of strongly interacting QCD matter at extremely high temperatures created in Pb-Pb collisions at LHC and provides further insight into small-system physics in (high-multiplicity) pp and p-Pb collisions. The ALICE collaboration presented 27 parallel talks, 50 posters, and 1 flash talk at Quark Matter 2015 and covered various topics including collective dynamics, correlations and fluctuations, heavy flavors, quarkonia, jets and high p{sub T} hadrons, electromagnetic probes, small system physics, and the upgrade program. This paper highlights some of the selected results.

  18. Recent QCD results from ATLAS

    CERN Document Server

    Meyer, C; The ATLAS collaboration

    2014-01-01

    The ATLAS collaboration has performed studies of a wide range of QCD phenomena, from soft particle to hard photon and jet production. Recent soft-QCD measurements include studies of underlying event and vector meson production. Differential measurements of inclusive and dijet production provide stringent tests of high-order QCD predictions and provide input for determination of parton density functions. Measurements of isolated inclusive and di-photons cross sections for high transverse momentum photons test theoretical predictions of perturbative QCD and constrain parton density functions. An overview of these results is given.

  19. The OPERA Experiment. Latest results

    Energy Technology Data Exchange (ETDEWEB)

    Hollnagel, Annika [Universitaet Hamburg, Institut fuer Experimentalphysik (Germany); Collaboration: OPERA-Hamburg-Collaboration

    2015-07-01

    The long-baseline neutrino oscillation experiment OPERA has been designed for the direct observation of ν{sub τ} appearance in the CNGS ν{sub μ} beam. The OPERA detector is located at the LNGS underground laboratory, with a distance of 730 km from the neutrino source at CERN. It is a hybrid detector, combining the micrometric precision of emulsion cloud chambers with electronic detector elements for online readout. While CNGS beam data taking lasted from 2008 to 2012, the neutrino oscillation analysis is still ongoing. Updated results with increased statistics are presented, including the recent observation of ν{sub τ} appearance.

  20. RSG Deployment Case Testing Results

    Energy Technology Data Exchange (ETDEWEB)

    Owsley, Stanley L.; Dodson, Michael G.; Hatchell, Brian K.; Seim, Thomas A.; Alexander, David L.; Hawthorne, Woodrow T.

    2005-09-01

    The RSG deployment case design is centered on taking the RSG system and producing a transport case that houses the RSG in a safe and controlled manner for transport. The transport case was driven by two conflicting constraints, first that the case be as light as possible, and second that it meet a stringent list of Military Specified requirements. The design team worked to extract every bit of weight from the design while striving to meet the rigorous Mil-Spec constraints. In the end compromises were made primarily on the specification side to control the overall weight of the transport case. This report outlines the case testing results.

  1. Overview of recent ALICE results

    CERN Document Server

    Gunji, Taku

    2016-01-01

    The ALICE experiment explores the properties of strongly interacting QCD matter at extremely high temperatures created in Pb-Pb collisions at LHC and provides further insight into small-system physics in (high-multiplicity) pp and p-Pb collisions. The ALICE collaboration presented 27 parallel talks, 50 posters, and 1 flash talk at Quark Matter 2015 and covered various topics including collective dynamics, correlations and fluctuations, heavy flavors, quarkonia, jets and high $p_{\\rm T}$ hadrons, electromagnetic probes, small system physics, and the upgrade program. This paper highlights some of the selected results.

  2. Data bases for LDEF results

    Science.gov (United States)

    Bohnhoff-Hlavacek, Gail

    1993-01-01

    The Long Duration Exposure Facility (LDEF) carried 57 experiments and 10,000 specimens for some 200 LDEF experiment investigators. The external surface of LDEF had a large variety of materials exposed to the space environment which were tested preflight, during flight, and post flight. Thermal blankets, optical materials, thermal control paints, aluminum, and composites are among the materials flown. The investigations have produced an abundance of analysis results. One of the responsibilities of the Boeing Support Contract, Materials and Systems Special Investigation Group, is to collate and compile that information into an organized fashion. The databases developed at Boeing to accomplish this task is described.

  3. Results of nuclear fusion development

    International Nuclear Information System (INIS)

    Yamamoto, Kenzo

    1975-01-01

    Compared with the nuclear fission research which followed that in advanced countries, Japan has treaded on its own track in nuclear fusion development; in the former, she had been far behind other leading countries. Characteristic of the efforts in Japan is the collaboration with educational institutions. Works are now carried out mainly in Tokamak plasma confinement, though other means being studied simultaneously. The nation's fusion research program is the realization of a fusion reactor at the turn of the present century, based on the world-level results attained with Tokamak. Past developments in the nuclear fusion research, the current status, and aspects for the future are discribed. (Mori, K.)

  4. Engineering model cryocooler test results

    International Nuclear Information System (INIS)

    Skimko, M.A.; Stacy, W.D.; McCormick, J.A.

    1992-01-01

    This paper reports that recent testing of diaphragm-defined, Stirling-cycle machines and components has demonstrated cooling performance potential, validated the design code, and confirmed several critical operating characteristics. A breadboard cryocooler was rebuilt and tested from cryogenic to near-ambient cold end temperatures. There was a significant increase in capacity at cryogenic temperatures and the performance results compared will with code predictions at all temperatures. Further testing on a breadboard diaphragm compressor validated the calculated requirement for a minimum axial clearance between diaphragms and mating heads

  5. Recent results for Mark III

    International Nuclear Information System (INIS)

    Brient, J.C.

    1987-12-01

    This paper presents recent results from the Mark III detector at SPEAR, in the open charm sector. The first topic discussed is the reanalysis of the direct measurement of the D hadronic branching fractions, where a detailed study has been made of the Cabibbo suppressed and multi-π 0 's D decays backgrounds in the double tag sample. Next, the Dalitz plot analysis of the D decays to Kππ is presented, leading to the relative fractions of three-body versus pseudoscalarvector decays. 7 refs., 5 figs

  6. Results from Nikko-Maru

    International Nuclear Information System (INIS)

    Kinoshita, K.

    1990-01-01

    At the Nikko area of the TRISTAN storage ring the Search for Highly Ionizing Particles (SHIP) Nikko-Maru employs etchable solid state track detectors to search for heavily ionizing particles produced in the e + e - annihilations. New results are reported from exposures to 13.9 pb -1 integrated luminosity at √s=57-60.8 GeV. New upper limits are established on the production of Dirac monopoles with mass up to 28.8 GeV/c 2 . (author)

  7. Free-electron laser results

    International Nuclear Information System (INIS)

    Stein, W.E.; Brau, C.A.; Newnam, B.E.; Warren, R.W.; Winston, J.; Young, L.M.

    1981-01-01

    The Los Alamos free-electron laser (FEL) amplifier experiment was designed to demonstrate high efficiency for transfer of energy from an electron beam to a light beam in the magnetic field of a tapered wiggler. Initial results indicate an energy transfer consistent with theory. Distinct groups of decelerated electrons as well as accelerated electrons are clearly present in the energy spectrum of electrons emerging from the wiggler when the laser light is present. The observed energy decrease for the electrons captured in the decelerating bucket is approx. 6% and the average decrease of the entire energy distribution is approx. 2% for the conditions of these initial measurements

  8. Recent photon results from ATLAS

    CERN Document Server

    Glasman, Claudia; The ATLAS collaboration

    2017-01-01

    The production of prompt isolated photons at hadron colliders provides a stringent test of perturbative QCD and can be used to probe the gluon density function of the proton. The ATLAS collaboration has performed precise measurements of the inclusive production o f isolated prompt photons at a center-of-mass energy of 13 TeV, differential in both rap idity and the photon transverse momentum. In addition, the integrated and differential c ross sections for isolated photon pair production 8 TeV have been measured. The results are compared with state-of-the-art theory predictions at NLO in QCD and with predictions of several MC generators.

  9. Reporting of Diagnostic Cytogenetic Results.

    Science.gov (United States)

    Giersch, Anne B S; Bieber, Frederick R; Dubuc, Adrian M; Fletcher, Jonathan A; Ligon, Azra H; Mason-Suares, Heather; Morton, Cynthia C; Weremowicz, Stanislawa; Xiao, Sheng; Dal Cin, Paola

    2016-04-01

    This appendix, developed by the staff at the Center for Advanced Molecular Diagnostics in the Department of Pathology at the Brigham and Women's Hospital, includes a comprehensive list of current "macros" or standardized statements used to facilitate reporting of cytogenetic results. These are provided as a useful reference for other laboratories. The statements are organized under the general categories of constitutional or acquired abnormalities and subdivided into analysis type (GTG-banding, FISH, or chromosomal microarray). Multi-specimen usage macros are included that can be applied to two or more specimen types. Copyright © 2016 John Wiley & Sons, Inc.

  10. Optical Array Processor: Laboratory Results

    Science.gov (United States)

    Casasent, David; Jackson, James; Vaerewyck, Gerard

    1987-01-01

    A Space Integrating (SI) Optical Linear Algebra Processor (OLAP) is described and laboratory results on its performance in several practical engineering problems are presented. The applications include its use in the solution of a nonlinear matrix equation for optimal control and a parabolic Partial Differential Equation (PDE), the transient diffusion equation with two spatial variables. Frequency-multiplexed, analog and high accuracy non-base-two data encoding are used and discussed. A multi-processor OLAP architecture is described and partitioning and data flow issues are addressed.

  11. CELLO results on multiparticle production

    International Nuclear Information System (INIS)

    Podobrin, O.

    1991-10-01

    In this talk result from CELLO on multiparticle production in e + e - annihilation are presented. The three-dimensional distribution of charged particles, and its one- and two-dimensional projections, are extensively studied through the bin-size dependence of their factorial moments. The data are found to have an excellent description by standard Monte Carlo models. This implies an explanation of the observed intermittency behaviour in terms of known physics. The study is extended by an analysis of two-particle rapidity correlations. (orig.)

  12. First half 2005 financial results

    International Nuclear Information System (INIS)

    2005-01-01

    With manufacturing facilities in over 40 countries and a sales network in over 100, AREVA offers customers technological solutions for nuclear power generation and electricity transmission and distribution. The group also provides interconnect systems to the telecommunications, computer and automotive markets. This document presents the first half 2005 financial results of the group: 1 - overall performance: sales revenue, operating income, consolidated net income, operating cash flow, balance sheet; 2 - outlook; 3 - performance by business division: front-end division, reactors and services division, back end division, transmission and distribution division, connectors division

  13. Results of Austin Moore replacement.

    Directory of Open Access Journals (Sweden)

    Jadhav A

    1996-04-01

    Full Text Available Forty cases of Austin Moore Replacement done for transcervical fractures of the femur in patients were reviewed after a period of 12 to 48 months postoperatively (mean 26 mth. 30 cases (75% had mild to severe pain of non-infective origin, starting as early as 6 months postoperatively. This was irrespective of the make, size or position (varus/valgus of the prosthesis. Though the Aufranc and Sweet clinical scoring was satisfactory in 65% cases, radiological evidence of complications like sinking, protrusion, etc. were seen in majority of the cases. Calcar resorption was seen in 34 cases (85% as early as 4 months postoperatively. Results of THR and bipolar replacement done for transcervical fractures in recent literature show 85% pain-free cases at 5 years. We feel that Austin Moore Replacement should be reserved for patients more than 65 years of age and those who are less active or debilitated because of other factors, because of increased acetabular wear with time in the younger individual. This is corroborated by unsatisfactory results in patients less than 65 years of age (p < 0.05.

  14. Results from the NOMAD experiment

    CERN Document Server

    Popov, B A

    2000-01-01

    The NOMAD experiment has sought nu /sub mu / implies/implied by nu /sub tau / oscillations by looking for the emergence of tau /sup -/ in events from the CERN SPS neutrino beam. With some improvements in the techniques of analysis in relation to the results published previously and with the inclusion of data from the 1998 run, no evidence for the oscillations has been found, which results in an updated limit on the oscillation probability [P( nu /sub mu / to nu /sub tau /)<0.5* 10/sup -3/ at a 90% C.L.]. The corresponding limit on the oscillation mixing angle is given by sin/sup 2/2 theta /sub mu tau /<1.0*10/sup -3/ for large Delta m/sup 2/. By using a 1% contamination of nu /sub e/ in the neutrino beam, we can also rule out nu /sub e/ implies/implied by nu /sub tau / oscillations and constrain the probability of the relevant transition as P( nu /sub 3/ to nu /sub tau /)<3*10/sup -2/ at a 90% C.L. (sin/sup 2/2Q/sub e tau /<6*10/sup -2/ at large Delta m/sup 2/). (10 refs).

  15. Unfavourable results following reduction mammoplasty

    Directory of Open Access Journals (Sweden)

    Lakshmi Saleem

    2013-01-01

    Full Text Available Breast reduction is a common cosmetic surgical procedure. It aims not only at bringing down the size of the breast proportionate to the build of the individual, but also to overcome the discomfort caused by massive, ill-shaped and hanging breasts. The operative procedure has evolved from mere reduction of breast mass to enhanced aesthetic appeal with a minimum of scar load. The selection of technique needs to be individualised. Bilateral breast reduction is done most often. Haematoma, seroma, fat necrosis, skin loss, nipple loss and unsightly, painful scars can be the complications of any procedure on the breast. These may result from errors in judgement, wrong surgical plan and imprecise execution of the plan. Though a surfeit of studies are available on breast reduction, very few dwell upon its complications. The following article is a distillation of three decades of experience of the senior author (L.S. in reduction mammoplasty. An effort is made to understand the reasons for unfavourable results. To conclude, most complications can be overcome with proper selection of procedure for the given patient and with gentle tissue handling.

  16. First results of spherical GEMs

    CERN Document Server

    Pinto, Serge Duarte; Brock, Ian; Croci, Gabriele; David, Eric; de Oliveira, Rui; Ropelewski, Leszek; van Stenis, Miranda; Taureg, Hans; Villa, Marco

    2010-01-01

    We developed a method to make GEM foils with a spherical geometry. Tests of this procedure and with the resulting spherical GEMs are presented. Together with a spherical drift electrode, a spherical conversion gap can be formed. This eliminates the parallax error for detection of x-rays, neutrons or UV photons when a gaseous converter is used. This parallax error limits the spatial resolution at wide scattering angles. Besides spherical GEMs, we have developed curved spacers to maintain accurate spacing, and a conical field cage to prevent edge distortion of the radial drift field up to the limit of the angular acceptance of the detector. With these components first tests are done in a setup with a spherical entrance window but a planar readout structure; results will be presented and discussed. A flat readout structure poses difficulties, however. Therefore we will show advanced plans to make a prototype of an entirely spherical double-GEM detector, including a spherical 2D readout structure. This detector w...

  17. Drug overdose resulting in quadriplegia.

    Science.gov (United States)

    Wang, Teresa S; Grunch, Betsy H; Moreno, Jessica R; Bagley, Carlos A; Gottfried, Oren N

    2012-06-01

    To describe a case of cervical flexion myelopathy resulting from a drug overdose. A 56-year-old male presented to the emergency department unable to move his extremities following drug overdose. Neurological examination revealed him to be at C6 ASIA A spinal cord injury. The CT of his cervical spine revealed no fracture; however, an MRI revealed cord edema extending from C3 to C6 as well as posterior paraspinal signal abnormalities suggestive of ligamentous injury. The patient underwent a posterior cervical laminectomy and fusion from C3 to C7. Neurologically he regained 3/5 bilateral tricep function and 2/5 grip; otherwise, he remained at ASIA A spinal cord injury at 6 months. Our patient suffered a spinal cord injury likely due to existing cervical stenosis, and in addition to an overdose of sedating medications, he likely sat in flexed neck position for prolonged period of time with the inability to modify his position. This likely resulted in cervical spine vascular and/or neurological compromise producing an irreversible spinal cord injury. Spinal cord injury is a rare finding in patients presenting with drug overdose. The lack of physical exam findings suggestive of trauma may delay prompt diagnosis and treatment, and thus clinicians must have a high index of suspicion when evaluating patients in this setting.

  18. New Results on Cepheid Masses

    Science.gov (United States)

    Evans, N. R.; Bohm-Vitense, E.; Carpenter, K.; Robinson, R.; Beck-Winchatz, B.

    1996-12-01

    Masses for Cepheid variable stars can be measured by combining the orbital velocity amplitude for the Cepheid (from a ground-based orbit) with the orbital velocity amplitude of a hot main sequence companion (observed in the ultraviolet from satellites such as IUE and HST) and the mass of the companion (inferred from from the ultraviolet energy distribution). Observations of 5 binary systems are now completed or in progress with the Goddard High Resolution Spectrograph on the Hubble Space Telescope. Recently completed observations of U Aql lead to a mass of 5.1 +/- 1.1 Msun . We will discuss the results for S Mus, V350 Sgr, U Aql, and Y Car, and the constraints they place on stellar evolution calculations. As would be expected, some of the B companions have high rotational velocities, decreasing the accuracy with which their orbital velocities can be measured. The preliminary conclusion from the 4 HST targets and SU Cyg (mass from IUE observations) is that a weighted mean indicates no convective overshoot but the mode (which reflects the HST results better) agrees with the modest overshoot used in the Geneva evolutionary calculations. Financial Support was provided by a NASA grant GO-4541-01 to EB--V and GO-4541.02 to KGC, a grant from the Natural Sciences and Engineering Council, Canada to NRE, from the AXAF Science Center NASA Contract NAS8-39073.

  19. TMX-U experimental results

    International Nuclear Information System (INIS)

    Simonen, T.C.; Allen, S.L.; Casper, T.A.

    1983-01-01

    This paper describes results from the Tandem Mirror Experiment-Upgrade (TMX-U). Mirror-confined electrons with 30 to 70 keV mean energy densities of 0.5 to 2.0 x 10 12 cm -3 and average betas of 3 to 5% are produced using electron-cyclotron resonant heating (ECRH). These results are consistent with an electron Fokker-Planck code. Improved ion-cyclotron microstability is observed using neutral beam injection at 47 0 to the magnetic axis, rather than at 90 0 as in the previous experiment, TMX. Strong end plugging has been produced using a combination of ECRH gyrotrons with sloshing-ion beam injection. In these low-density central cell experiments (3 x 10 11 cm -3 ) the axial losses (tau/sub parallel/ = 20 to 80 ms) are smaller than the nonambipolar radial losses (tau/sub perpendicular/ = 4 to 8 ms). Plugging has been achieved with a central cell density double that of the end plugs. Although no direct measurements are yet available to determine if a thermal barrier potential dip is generated, these experiments support many theoretical features of the thermal barrier concept

  20. Results of the dosimetry intercomparison

    International Nuclear Information System (INIS)

    Dure, Elsa S.

    2000-07-01

    The appropriate way to verify the accuracy of the results of dose reported by the laboratories that offer lend personal dosimetry service is in the periodic participation of round of intercomparison dosimetry, undertaken by laboratories whose standards are trace (Secondary Laboratory). The Laboratory of External Personal Dosimetry of the CNEA-PY has participated in three rounds of intercomparison. The first two were organized in the framework of the Model Project RLA/9/030 RADIOLOGICAL WASTE SECURITY, and the irradiations were carried out in the Laboratory of Regional Calibration of the Center of Nuclear Technology Development, Belo Horizonte-Brazil (1998) and in the National Laboratory of Metrology of the ionizing radiations of the Institute of Radioprotection and Dosimetry, Rio de Janeiro-Brazil (1999). The third was organized by the IAEA and the irradiations were made in the Physikalisch-Technische Bundesanstalt PTB, Braunschweig - Federal Republic of Germany (1999-2000) [es

  1. Framatome announces its 1997 results

    International Nuclear Information System (INIS)

    1998-01-01

    This press dossier presents the 1997 financial year of Framatome group: turnover and key-numbers, results, sectoral analysis (nuclear engineering (nuclear realizations, fuels, services and equipments); connectors engineering (automotive, electrical, electronic, interconnection and microelectronic industries), industrial equipments). Then, the 1998 objectives are presented with the strategy of the group (Chinese, central and eastern Europe nuclear programs, French-German joint EPR project, services and nuclear fuels, connectors engineering, industrial equipments, manpower, research and development programs). This part is followed by a presentation of some 1997 events and by the text of the press conference from May 18, 1998 which presented the activities of the group, its competences and know-how in the nuclear domain. (J.S.)

  2. Recent results on Tore Supra

    International Nuclear Information System (INIS)

    Moreau, D.

    1995-01-01

    Recent results regarding heating, confinement, current drive and profile modifications, heat and particle exhaust are reported. Improved core confinement is obtained after pellet injection (PEP) or Lower Hybrid current drive (LHEP) and may be linked with small - or reversed - central magnetic shear. Conversely, by increasing the magnetic shear in the gradient region, both LHCD and fast wave electron heating (FWEH) have produced improved global confinement was carried by the bootstrap current. Fast wave current drive has been observed at the level of 80 kA in a 0.4 MA discharge. In the ergodic divertor configuration, stable radiative layers were obtained with neon injection. At least 80% of a total of 7 MW injected power were radiated without confinement degradation or impurity accumulation. Finally, the heat exhaust capability of the various actively cooled plasma facing components is briefly described. (author) 14 refs.; 13 figs

  3. First results on fast baking

    Energy Technology Data Exchange (ETDEWEB)

    Visentin, B. [CEA-Saclay, DSM/DAPNIA/SACM - 91191 Gif/Yvette Cedex (France)]. E-mail: bvisentin@cea.fr; Gasser, Y. [CEA-Saclay, DSM/DAPNIA/SACM - 91191 Gif/Yvette Cedex (France); Charrier, J.P. [CEA-Saclay, DSM/DAPNIA/SACM - 91191 Gif/Yvette Cedex (France)

    2006-07-15

    High gradient performances of bulk niobium cavities go through a low-temperature baking during one or two days, the temperature parameter is adjusted in a narrow tuning range around 110 or 120deg, C. With such treatment, the intrinsic quality factor Q{sub 0} is improved at high fields. Assuming the oxygen diffusion is involved in this phenomenon, we have developed the 'fast baking' (145deg, C/3h) as an alternative method. Similar results have been achieved with this method compared to standard baking. Consequently, for the first time, a link between oxygen diffusion and high field Q-slope has been demonstrated. Furthermore, this method open the way to a simpler and better baking procedure for the large-scale cavity production due to:*time reduction and *possibility to combine baking and drying during cavity preparation.

  4. Cassini at Saturn Huygens results

    CERN Document Server

    Harland, David M

    2007-01-01

    "Cassini At Saturn - Huygens Results" will bring the story of the Cassini-Huygens mission and their joint exploration of the Saturnian system right up to date. Cassini is due to enter orbit around Saturn on the 1 July 2004 and the author will have 8 months of scientific data available for review, including the most spectacular images of Saturn, its rings and satellites ever obtained by a space mission. As the Cassini spacecraft approached its destination in spring 2004, the quality of the images already being returned by the spacecraft clearly demonstrate the spectacular nature of the close-range views that will be obtained. The book will contain a 16-page colour section, comprising a carefully chosen selection of the most stunning images to be released during the spacecraft's initial period of operation. The Huygens craft will be released by Cassini in December 2004 and is due to parachute through the clouds of Saturn's largest moon, Titan, in January 2005.

  5. First results on fast baking

    International Nuclear Information System (INIS)

    Visentin, B.; Gasser, Y.; Charrier, J.P.

    2006-01-01

    High gradient performances of bulk niobium cavities go through a low-temperature baking during one or two days, the temperature parameter is adjusted in a narrow tuning range around 110 or 120deg, C. With such treatment, the intrinsic quality factor Q 0 is improved at high fields. Assuming the oxygen diffusion is involved in this phenomenon, we have developed the 'fast baking' (145deg, C/3h) as an alternative method. Similar results have been achieved with this method compared to standard baking. Consequently, for the first time, a link between oxygen diffusion and high field Q-slope has been demonstrated. Furthermore, this method open the way to a simpler and better baking procedure for the large-scale cavity production due to:*time reduction and *possibility to combine baking and drying during cavity preparation

  6. Treatment Results of Ovarian Dysqerminoma

    International Nuclear Information System (INIS)

    Chung, Eun Ji; Suh, Chang Ok; Seong, Jin Sil; Keum, Ki Chang; Kim, Gwi Eon

    1996-01-01

    Purpose : We tried to evaluate the clinical characteristics, the treatment methods, the results of treatments, and the patterns of failure in ovarian dysgerminoma retrospectively. According to the results we would like to suggest the proper management guideline of stage la ovarian dysgerminoma patients who want to maintain fertility. Methods and Materials : Between 1975 and 1990, 34 patients with ovarian dysgerminoma were treated at the Yonsei University Hospital. The case records of these patients have been reviewed for presenting symptoms, treatment methods, local control, and survival following treatment. Excluded from analysis were five patients with mixed ovarian germ cell tumors and gonadoblastomas (46,XY). Treatment results of the twenty nine patients were analysed by each treatment modality. Twenty one patients were treated with surgery and postoperative adjuvant radiotherapy(group 1). The other eight patients were treated with operation alone (group 2). The median age of twenty-nine patients was 23 years with a range of 8 to 39 years. Presenting symptoms were abdominal mass(20), pelvic discomfort or pain(5) et al. Radiotherapy was performed by 10MV LINAC or Co-60 teletherapy unit. The total radiation dose of the whole abdomen was 20-25 Gy/3 weeks, 1-1.5 Gy/fraction with a boost to the whole pelvis 10-15 Gy / 1-2 weeks1.8-2.0 Gy/fraction. Advanced stage disease (stage II or stage III) patients received prophylactic mediastinal and supraclavicular irradiation to a dose of 16-26 Gy. Median duration of follow-up of living patients was 80 months (range : 13-201 months). Results : All of the twenty one patients of group 1 were alive without disease (100%). Among the eight patients who were not treated with radiotherapy (group 2), six patients developed local recurrence. Four patients referred with recurrent disease were treated with salvage radiotherapy. Three of four patients were salvaged and one patient who had recurrent intra-abdominal disease died of

  7. Latest results from KLOE-2

    Directory of Open Access Journals (Sweden)

    Bloise Caterina

    2014-01-01

    Full Text Available The KLOE experiment at the Frascati φ–factory recently obtained results on i CPT and Lorentz invariance tests from the study of quantum interference of the neutral kaon pairs; ii precision measurement of the branching fraction, BR(K+ → π+π−π+(γ = 0.05565 ± 0.00031stat ± 0.00025syst, and iii on dark photon searches with the analysis of the e+e− → µµγ final state. We have also studied the transition form factors of the φ meson to the pseudoscalars, π0 and η, that is presented in a separate contribution to this volume.

  8. The Bigfoot Drive; Experimental Results

    Science.gov (United States)

    Baker, Kevin; Thomas, Cliff; Khan, Shahab; Casey, Daniel; Spears, Brian; Nora, Ryan; Munro, Davis; Eder, David; Milovich, Jose; Berger, Dick; Strozzi, David; Goyon, Clement; Turnbull, David; Ma, Tammy; Izumi, Nobuhiko; Benedetti, Robin; Millot, Marius; Celliers, Peter; Yeamans, Charles; Hatarik, Robert; Landen, Nino; Hurricane, Omar; Callahan, Debbie

    2016-10-01

    The Bigfoot platform was developed on the National Ignition Facility to investigate low convergence, high adiabat, high rhoR hotspot implosions. This platform was designed to be less susceptible to wall motion, LPI and CBET and to be more robust against capsule hydrodynamic instabilities. To date experimental studies have been carried out at two hohlraum scales, a 5.75 and 5.4 mm diameter hohlraum. We will present experimental results from these tuning campaigns including the shape vs. cone fraction, surrogacy comparisons of self-emission from the capsules vs. radiography of the imploding capsule and doped vs. undoped capsules. Prepared by LLNL under Contract DE-AC52-07NA27344.

  9. Some results on inverse scattering

    International Nuclear Information System (INIS)

    Ramm, A.G.

    2008-01-01

    A review of some of the author's results in the area of inverse scattering is given. The following topics are discussed: (1) Property C and applications, (2) Stable inversion of fixed-energy 3D scattering data and its error estimate, (3) Inverse scattering with 'incomplete' data, (4) Inverse scattering for inhomogeneous Schroedinger equation, (5) Krein's inverse scattering method, (6) Invertibility of the steps in Gel'fand-Levitan, Marchenko, and Krein inversion methods, (7) The Newton-Sabatier and Cox-Thompson procedures are not inversion methods, (8) Resonances: existence, location, perturbation theory, (9) Born inversion as an ill-posed problem, (10) Inverse obstacle scattering with fixed-frequency data, (11) Inverse scattering with data at a fixed energy and a fixed incident direction, (12) Creating materials with a desired refraction coefficient and wave-focusing properties. (author)

  10. Selected recent results from AMANDA

    CERN Document Server

    Andrés, E; Bai, X; Barouch, G; Barwick, S W; Bay, R C; Becker, K H; Bergström, L; Bertrand, D; Bierenbaum, D; Biron, A; Booth, J; Botner, O; Bouchta, A; Boyce, M M; Carius, S; Chen, A; Chirkin, D; Conrad, J; Cooley, J; Costa, C G S; Cowen, D F; Dailing, J; Dalberg, E; De Young, T R; Desiati, P; Dewulf, J P; Doksus, P; Edsjö, J; Ekstrom, P; Erlandsson, B; Feser, T; Gaug, M; Goldschmidt, A; Goobar, A; Gray, L; Haase, H; Hallgren, A; Halzen, F; Hanson, K; Hardtke, R; He, Y D; Hellwig, M; Heukenkamp, H; Hill, G C; Hulth, P O; Hundertmark, S; Jacobsen, J; Kandhadai, V; Karle, A; Kim, J; Koci, B; Köpke, L; Kowalski, M; Leich, H; Leuthold, M; Lindahl, P; Liubarsky, I; Loaiza, P; Lowder, D M; Ludvig, J; Madsen, J; Marciniewski, P; Matis, H S; Mihályi, A; Mikolajski, T; Miller, T C; Minaeva, Y; Miocinovic, P; Mock, P C; Morse, R; Neunhoffer, T; Newcomer, F M; Niessen, P; Nygren, D R; Ogelman, H; Heros, C P D L; Porrata, R; Price, P B; Rawlins, K; Reed, C; Rhode, W; Richards, A; Richter, S; Martino, J R; Romenesko, P; Ross, D; Rubinstein, H; Sander, H G; Scheider, T; Schmidt, T; Schneider, D; Schneider, E; Schwarzl, R; Silvestri, A; Solarz, M; Spiczak, G M; Spiering, C; Starinsky, N; Steele, D; Steffen, P; Stokstad, R G; Streicher, O; Sun, A; Taboada, I; Thollander, L; Thon, T; Tilav, S; Usechak, N; Donckt, M V; Walck, C; Weinheimer, C; Wiebusch, C; Wischnewski, R; Wissing, H; Woschnagg, K; Wu, W; Yodh, G; Young, S

    2001-01-01

    We present a selection of results based on data taken in 1997 with the 302-PMT Antarctic Muon and Neutrino Detector Array-B10 ("AMANDA-B10") array. Atmospheric neutrinos created in the northern hemisphere are observed indirectly through their charged current interactions which produce relativistic, Cherenkov-light-emitting upgoing muons in the South Pole ice cap. The reconstructed angular distribution of these events is in good agreement with expectation and demonstrates the viability of this ice-based device as a neutrino telescope. Studies of nearly vertical upgoing muons limit the available parameter space for WIMP dark matter under the assumption that WIMPS are trapped in the earth's gravitational potential well and annihilate with one another near the earth's center.

  11. Cerebral infarcts resulting from trauma

    International Nuclear Information System (INIS)

    Busch, G.

    1985-01-01

    Vascular occlusions due to cerebral trauma have always been regarded as great rarities. However, we have found hypo-dense foci of vascular distribution in 3.5% of 3500 CT examinations for trauma during the late phase. Lesions in the vascular territory of the posterior cerebral artery are usually the result of supratentorial pressure rise from epidural and subdural haematomas, leading to compression of the vessels against the edge of the tentorium. Typical infacts in the territory of the medial and anterior cerebral arteries were found only rarely by CT after cerebral trauma. Infarcts at the watersheds between the three vascular territories were found with surprising frequency and small infarcts were found in the basal ganglia. It is assumed that these were due to ischaemic or hypoxic events due to cardiac or pulmonary complications during the initial phase. (orig.) [de

  12. Results from the AMANDA detector

    CERN Document Server

    Ackermann, M; Albrecht, H; Bai, X; Bartelt, M; Barwick, S W; Bay, R; Becka, T; Becker, J K; Becker, K H; Bernardini, E; Bertrand, D; Boersma, D J; Boser, S; Botner, O; Bouchta, A; Bouhali, O; Braun, J; Burgess, C; Burgess, T; Castermans, T; Chirkin, D; Collin, B; Conrad, J; Cooley, J; Cowen, D F; Davour, A; De Clercq, C; Pérez de los Heros, C; De Young, T R; Desiati, P; Ekstrom, P; Feser, T; Gaisser, T K; Ganugapati, R; Geenen, H; Gerhardt, L; Goldschmidt, A; Gross, A; Hallgren, A; Halzen, F; Hanson, K; Hardtke, R; Harenberg, T; Hauschildt, T; Helbing, K; Hellwig, M; Herquet, P; Hill, G C; Hodges, J; Hubert, D; Hughey, B; Hulth, P O; Hultqvist, K; Hundertmark, S; Jacobsen, J; Kampert, K H; Karle, A; Kelley, J; Kestel, M; Köpke, L; Kowalski, M; Krasberg, M; Kühn, K; Leich, H; Leuthold, M; Liubarsky, I; Madsen, J; Mandli, K; Marciniewski, P; Martino, J R; Matis, H S; McParland, C P; Messarius, T; Minaeva, Y; Miocinovic, P; Morse, R; Munich, K; Nahnhauer, R; Nam, J W; Neunhoffer, T; Niessen, P; Nygren, D R; Ogelman, H; Olbrechts, P; Pohl, A C; Porrata, R; Price, P B; Przybylski, G T; Rawlins, K; Resconi, E; Rhode, W; Ribordy, M; Richter, S; Sander, H G; Schinarakis, K; Schlenstedt, S; Schneider, D; Schwarz, R; Silvestri, A; Solarz, M; Spiczak, G M; Spiering, C; Stamatikos, M; Steele, D; Steffen, P; Stokstad, R G; Sulanke, K H; Taboada, I; Thollander, L; Tilav, S; Wagner, W; Walck, C; Walter, M; Wang, Y R; Wiebusch, C; Wischnewski, R; Wissing, H; Woschnagg, K; Yodh, G

    2004-01-01

    The Antarctic Muon And Neutrino Detector Array (AMANDA) is a high- energy neutrino telescope based at the geographic south pole. It is a lattice of photomultiplier tubes buried deep in the polar ice, which is used as interaction and detection medium. The primary goal of this detector is the observation of astronomical sources of high-energy neutrinos. This paper shows the latest results of the search for a diffuse flux of extraterrestrial nu /sub mu /s with energies between 10/sup 11/ eV and 10/sup 18/ eV, nu /sub mu /s emitted from point sources and nu /sub mu /s from dark matter annihilation in the Earth and the Sun.

  13. MITG test procedure and results

    International Nuclear Information System (INIS)

    Eck, M.E.; Mukunda, M.

    1983-01-01

    Elements and modules for Radioisotope Thermoelectric Generator have been performance tested since the inception of the RTG program. These test articles seldom resembled flight hardware and often lacked adequate diagnostic instrumentation. Because of this, performance problems were not identified in the early stage of program development. The lack of test data in an unexpected area often hampered the development of a problem solution. A procedure for conducting the MITG Test was developed in an effort to obtain data in a systematic, unambiguous manner. This procedure required the development of extensive data acquisition software and test automation. The development of a facility to implement the test procedure, the facility hardware and software requirements, and the results of the MITG testing are the subject of this paper

  14. CREAM: Results, Implications and Outlook

    CERN Document Server

    Seo, Eun-Suk

    The Cosmic Ray Energetics And Mass (CREAM) balloon-borne experiment has accumulated ∼161 days of exposure during six successful flights over Antarctica. Energy measurements are made with a transition radiation detector and an ionization calorimeter. Charge measurements are made with timing scintillators, pixelated Si, and Cherenkov detectors to minimize the effect of backscattered particles. High energy cosmicray data were collected over a wide energy range from ∼ 1010 to ∼ 1015 eV at an average altitude of ∼ 38.5 km, with ∼ 3.9 g/cm2 atmospheric overburden. All cosmic-ray elements from protons (Z = 1) to iron nuclei (Z = 26) are separated with excellent charge resolution. Recent results from the ongoing analysis including the discrepant hardening of elemental spectra at ∼ 200 GeV/n are presented and their implications on cosmic-ray origin, acceleration and propagation are discussed. The project status and plans are also presented.

  15. Benchmark results in radiative transfer

    International Nuclear Information System (INIS)

    Garcia, R.D.M.; Siewert, C.E.

    1986-02-01

    Several aspects of the F N method are reported, and the method is used to solve accurately some benchmark problems in radiative transfer in the field of atmospheric physics. The method was modified to solve cases of pure scattering and an improved process was developed for computing the radiation intensity. An algorithms for computing several quantities used in the F N method was done. An improved scheme to evaluate certain integrals relevant to the method is done, and a two-term recursion relation that has proved useful for the numerical evaluation of matrix elements, basic for the method, is given. The methods used to solve the encountered linear algebric equations are discussed, and the numerical results are evaluated. (M.C.K.) [pt

  16. Results from T2K

    International Nuclear Information System (INIS)

    Di Luise, S.

    2014-01-01

    T2K is an off-axis long baseline neutrino oscillation experiment designed to measure the θ 13 mixing parameter through the observation of ν e appearance in a ν μ beam. Concurrent measurement of ν μ disappearance allows refined measurements of the atmospheric Δm 23 2 and of the θ 23 mixing parameters. Analysis of data taken from January 2010 to March 2011 led to the first indication to ν μ → ν e appearance, it means θ 13 ≠ 0 (2.5σ significance), opening the way to CP violation searches in the leptonic sector. Measurement for ν μ disappearance were performed as well. Data taking restarted in March 2012 at higher intensities. Results, data taking status and future plans will be discussed. (author)

  17. Recent charmonium results at BESIII

    International Nuclear Information System (INIS)

    Guo, Y.

    2014-01-01

    Recent results on the charmonium decays based on 1.06*10 8 ψ' events taken with the BESIII (Beijing Spectrometer) detector operating at the BEPCII e + e - collider are presented in this talk. The properties and line-shape of η c , the production rate and properties of h c , and the first observation of the M1 transition φ' → γη' c are reported. In addition, the new decay modes of η' c are searched for in ρρ, K* 0 K-bar* 0 , and φφ final states, and the measurement of the multipole amplitude in ψ' → γχ c2 is presented. (author)

  18. HEAO A-2 extragalactic results

    Science.gov (United States)

    Boldt, E. A.

    1979-01-01

    The all-sky surveys made with the A-2 instrument aboard HEAO-1 involved spectroscopy over a broad enough band width, with sufficient resolution, to obtain the basic spectral characteristics for two extreme aspects of the extragalactic X-ray sky. The overall spectrum (above 3 KeV) is remarkably well decribed by a thermal model. At the other extreme, the detailed broad-band observations of individual sources are restricted to objects within the present epoch. The objects include several individual active galaxies studied in detail for the first time as well as clusters of galaxies. Relating these results to the vast spatially unresolved hard X-ray flux measured with this instruments as well as the softer X-rays (at less than 3 keV) spatially resolved to high redshifts with the Einstein Observatory remains a challenge.

  19. Recent ATLAS Heavy Ion results

    CERN Multimedia

    CERN. Geneva

    2012-01-01

    Lead nucleus collisions in the LHC recreate the state of matter which existed when the universe was a few microseconds old. This super-hot matter, composed of quark and gluons, emits thousands of particles as it expands, cools and converts back into hadrons. The ATLAS detector provides an excellent opportunity to perform detailed studies of this novel state of matter, measuring its bulk properties and its response to penetrating probes. Recent studies of particle correlations and fluctuations shed light on the initial geometry and its evolution into the final state. Studies of jet suppression and fragmentation show how the energetic partons interact with the medium. High precision measurements of boson production and first results on boson-jet correlations are important steps towards quantitative understanding of the parton energy loss mechanism.

  20. Results from ISTC frame work

    Energy Technology Data Exchange (ETDEWEB)

    Fukahori, Tokio [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1998-03-01

    Under International Science Research Center (ISTC) projects, JAERI Nuclear Data Center has been taking a role of collaborator and monitor for following items; (1) Measurement of the Fission Neutron Spectra of the Minor Actinides and Spontaneous Fission of Curium Isotopes (ISTC no. 183: V.I. Khlopin Radium Institute, KRI, St. Petersburg, Russia), (2) Measurement and Analysis of the Basic Nuclear Data for Minor Actinides (ISTC no. 304: Institute of Physics and Power Engineering, IPPE, Obninsk, Russia), and Evaluation of Actinide Nuclear Data (ISTC no. CIS-3: Radiation Physics and Chemistry Problems Institute, RPCPI, Minsk, Belarus). These are related to the Japanese OMEGA Project and expected to supply minor actinide (MA) nuclear data, since Russia has good quality MA samples, experimental technique and nuclear data evaluation experiences. In this report, out-line and some results of above three projects are reviewed. (author)

  1. Recent SUSY results in ATLAS

    CERN Document Server

    Mamuzic, Judita; The ATLAS collaboration

    2018-01-01

    Supersymmetry (SUSY) is considered one of the best motivated extensions of the Standard Model. It postulates a fundamental symmetry between fermions and bosons, and introduces a set of new supersymmetric particles at the electroweak scale. It addresses the hierarchy and natu- ralness problem, gives a solution to the gauge couplings unification, and offers a cold dark matter candidate. Different aspects of SUSY searches, using strong, electroweak, third generation production, R-parity violation models, and long lived particles are being studied at the LHC. An overview of most recent results in SUSY searches using Run 2 ATLAS data, at 13 TeV with 36.1 fb−1 of integrated luminosity, was presented.

  2. Results from KASCADE–Grande

    International Nuclear Information System (INIS)

    Bertaina, M.; Apel, W.D.; Arteaga-Velázquez, J.C.; Bekk, K.; Blümer, J.; Bozdog, H.; Brancus, I.M.; Buchholz, P.; Cantoni, E.; Chiavassa, A.; Cossavella, F.

    2012-01-01

    The KASCADE–Grande experiment, located at Karlsruhe Institute of Technology (Germany) is a multi-component extensive air-shower experiment devoted to the study of cosmic rays and their interactions at primary energies 10 14 –10 18 eV. Main goals of the experiment are the measurement of the all-particle energy spectrum and mass composition in the 10 16 –10 18 eV range by sampling charged (N ch ) and muon (N μ ) components of the air shower. The method to derive the energy spectrum and its uncertainties, as well as the implications of the obtained result, is discussed. An overview of the analyses performed by KASCADE–Grande to derive the mass composition of the measured high-energy comic rays is presented as well.

  3. Results from KASCADE-Grande

    Energy Technology Data Exchange (ETDEWEB)

    Bertaina, M., E-mail: bertaina@to.infn.it [Dipartimento di Fisica Generale dell' Universita, Torino (Italy); Apel, W.D. [Institut fuer Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); Arteaga-Velazquez, J.C. [Universidad Michoacana, Instituto de Fisica y Matematicas, Morelia (Mexico); Bekk, K. [Institut fuer Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); Bluemer, J. [Institut fuer Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); Institut fuer Experimentelle Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); Bozdog, H. [Institut fuer Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); Brancus, I.M. [National Institute of Physics and Nuclear Engineering, Bucharest (Romania); Buchholz, P. [Fachbereich Physik, Universitaet Siegen (Germany); Cantoni, E. [Dipartimento di Fisica Generale dell' Universita, Torino (Italy); Istituto di Fisica dello Spazio Interplanetario, INAF Torino (Italy); Chiavassa, A. [Dipartimento di Fisica Generale dell' Universita, Torino (Italy); Cossavella, F. [Institut fuer Experimentelle Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); and others

    2012-11-11

    The KASCADE-Grande experiment, located at Karlsruhe Institute of Technology (Germany) is a multi-component extensive air-shower experiment devoted to the study of cosmic rays and their interactions at primary energies 10{sup 14}-10{sup 18} eV. Main goals of the experiment are the measurement of the all-particle energy spectrum and mass composition in the 10{sup 16}-10{sup 18} eV range by sampling charged (N{sub ch}) and muon (N{sub {mu}}) components of the air shower. The method to derive the energy spectrum and its uncertainties, as well as the implications of the obtained result, is discussed. An overview of the analyses performed by KASCADE-Grande to derive the mass composition of the measured high-energy comic rays is presented as well.

  4. Energy 21. Preconditions and results

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    In 1988 the Danish government adopted an action plan for the environment and sustainable development. In 1990, the energy aspects of this plan were embodied in Energy 2000 and, in 1993, in Energy 2000 follow-up. The objective is a 20% reduction of CO{sub 2} emissions by the year 2005, compared with the level in 1988. Various measures are therefore being taken as time passes to help achieve this objective. As part of the monitoring of developments in the energy sector, it is necessary to take stock from time to time and to assess the direction in which the sector is moving. The government has therefore drawn up a new energy action plan, Energy 21, both to ensure that the overall objectives in the current plan are actively followed up on and to look ahead at the possibilities for action after the year 2005. The Danish Energy Agency has previously carried out a number of analyses of the technological and behavioural possibilities for reducing energy consumption in the short and the long term, for improving the efficiency of energy supply installations, and for using new and sustainable energy technologies. The results of this work are described in the report Denmark`s Energy Futures. The calculations in the report itself and its appendices. The more detailed assumptions and a description of the methods of analysis etc. are given in Basis for Analysis of Denmark`s Energy Futures. This report contains the assumptions, a description of methods and some of the results of the work on Energy 21. (au)

  5. Recent QCD Results from SLD

    International Nuclear Information System (INIS)

    Muller, David

    1999-01-01

    We present selected results on strong interaction physics from the SLD experiment at the SLAC Linear Collider. We report on several new studies of 3- and 4-jet hadronic Z 0 decays, in which jets are identified as quark, antiquark or gluon. The 3-jet Z 0 --> b anti-bg rate is sensitive to the b-quark mass; prospects for measuring m b are discussed. The gluon energy spectrum is measured over the full kinematic range, providing an improved test of QCD and limits on anomalous b anti-bg couplings. The parity violation in Z 0 --> b anti-bg decays is consistent with electroweak theory plus QCD. New tests of T- and CP-conservation at the bbg vertex are performed. A new measurement of the rate of gluon splitting into b anti-b pairs yields g b anti-b = 0.0031 ± 0.0007 (stat.)± 0.0006 (syst.) (Preliminary). We also present a number of new results on jet fragmentation into identified hadrons. The B hadron energy spectrum is measured over the full kinematic range using a new, inclusive technique, allowing stringent tests of predictions for its shape and a precise measurement of (xB) = 0.714 ± 0.005(stat.) ± 0.007(syst.) (Preliminary). A detailed study of correlations in rapidity y between pairs of identified pi ± , K ± and p/anti-p confirms that strangeness and baryon number are conserved locally, and shows local charge conservation between meson-baryon and strange-nonstrange pairs. Flavor-dependent long-range correlations are observed for all combinations of these hadron species, yielding new information on leading particle production. The first study of correlations using rapidities signed such that y > 0 corresponds to the quark direction provides additional new insights into fragmentation, including the first direct observation of baryon number ordering along the q anti-q axis

  6. RESULTS OF SUPPLEMENTAL MST STUDIES

    International Nuclear Information System (INIS)

    Peters, T; David Hobbs, D; Samuel Fink, S

    2006-01-01

    The current design of the Salt Waste Processing Facility (SWPF) includes an auxiliary facility, the Actinide Finishing Facility, which provides a second contact of monosodium titanate (MST) to remove soluble actinides and strontium from waste if needed. This treatment will occur after cesium removal by Caustic-Side Solvent Extraction (CSSX). Although the process changes and safety basis implications have not yet been analyzed, provisions also exist to recover the MST from this operation and return to the initial actinide removal step in the SWPF for an additional (third) contact with fresh waste. A U.S. Department of Energy (DOE) request identified the need to study the following issues involving this application of MST: Determine the effect of organics from the solvent extraction (CSSX) process on radionuclide sorption by MST; Determine the efficiency of re-using MST for multiple contacts; and Examine fissile loading on MST under conditions using a waste containing significantly elevated concentrations of plutonium, uranium, neptunium, and strontium. This report describes the results of three experimental studies conducted to address these needs: (1) Addition of high concentrations of entrained CSSX solvent had no noticeable effect, over a two week period, on the sorption of the actinides and strontium by MST in a direct comparison experiment. (2) Test results show that MST still retains appreciable capacity after being used once. For instance, reused MST--in the presence of entrained solvent--continued to sorb actinides and strontium. (3) A single batch of MST was used to sequentially contact five volumes of a simulant solution containing elevated concentrations of the radionuclides of interest. After the five contacts, we measured the following solution actinide loadings on the MST: plutonium: 0.884 ± 0.00539 wt % or (1.02 ± 0.0112) E+04 (micro)g/g MST, uranium: 12.1 ± 0.786 wt % or (1.40 ± 0.104) E+05 (micro)g/g MST, and neptunium: 0.426 ± 0.00406 wt % or

  7. TFTR D-T results

    International Nuclear Information System (INIS)

    Meade, D.M.

    1994-01-01

    Temperatures, densities and confinement of deuterium plasmas confined in tokamaks have been achieved within the last decade that are approaching those required for a D-T reactor. As a result, the unique phenomena present in a D-T reactor plasma (D-T plasma confinement, alpha confinement, alpha heating and possible alpha driven instabilities) can now be studied in the laboratory. Recent experiments on the Tokamak Fusion Test Reactor (TFTR) have been the first magnetic fusion experiments to study plasmas with reactor fuel concentrations of tritium. The injection of ∼ 20 MW of tritium and 14 MW of deuterium neutral beams into the TFTR produced a plasma with a T/D density ratio of ∼1 and yielded a maximum fusion power of ∼ 9.2 MW. The fusion power density in the core of the plasma was ∼ 1.8 MW m -3 approximating that expected in a D-T fusion reactor. A TFTR plasma with T/D density ratio of ∼ 1 was found to have ∼ 20% higher energy confinement time than a comparable D plasma, indicating a confinement scaling with average ion mass, A, of τ E ∼ A 0.6 . The core ion temperature increased from 30 keV to 37 keV due to a 35% improvement of ion thermal conductivity. Using the electron thermal conductivity from a comparable deuterium plasma, about 50% of the electron temperature increase from 9 keV to 10.6 keV can be attributed to electron heating by the alpha particles. The ∼ 5% loss of alpha particles, as observed on detectors near the bottom edge of the plasma, was consistent with classical first orbit loss without anomalous effects. Initial measurements have been made of the confined energetic alphas and the resultant alpha ash density. At fusion power levels of 7.5 MW, fluctuations at the Toroidal Alfven Eigenmode frequency were observed by the fluctuation diagnostics. However, no additional alpha loss due to the fluctuations was observed

  8. Evaluating the RELM Test Results

    Directory of Open Access Journals (Sweden)

    Michael K. Sachs

    2012-01-01

    Full Text Available We consider implications of the Regional Earthquake Likelihood Models (RELM test results with regard to earthquake forecasting. Prospective forecasts were solicited for M≥4.95 earthquakes in California during the period 2006–2010. During this period 31 earthquakes occurred in the test region with M≥4.95. We consider five forecasts that were submitted for the test. We compare the forecasts utilizing forecast verification methodology developed in the atmospheric sciences, specifically for tornadoes. We utilize a “skill score” based on the forecast scores λfi of occurrence of the test earthquakes. A perfect forecast would have λfi=1, and a random (no skill forecast would have λfi=2.86×10-3. The best forecasts (largest value of λfi for the 31 earthquakes had values of λfi=1.24×10-1 to λfi=5.49×10-3. The best mean forecast for all earthquakes was λ̅f=2.84×10-2. The best forecasts are about an order of magnitude better than random forecasts. We discuss the earthquakes, the forecasts, and alternative methods of evaluation of the performance of RELM forecasts. We also discuss the relative merits of alarm-based versus probability-based forecasts.

  9. Salt decontamination demonstration test results

    International Nuclear Information System (INIS)

    Snell, E.B.; Heng, C.J.

    1983-06-01

    The Salt Decontamination Demonstration confirmed that the precipitation process could be used for large-scale decontamination of radioactive waste sale solution. Although a number of refinements are necessary to safely process the long-term requirement of 5 million gallons of waste salt solution per year, there were no observations to suggest that any fundamentals of the process require re-evaluation. Major accomplishments were: (1) 518,000 gallons of decontaminated filtrate were produced from 427,000 gallons of waste salt solution from tank 24H. The demonstration goal was to produce a minimum of 200,000 gallons of decontaminated salt solution; (2) cesium activity in the filtrate was reduced by a factor of 43,000 below the cesium activity in the tank 24 solution. This decontamination factor (DF) exceeded the demonstration goal of a DF greater than 10,000; (3) average strontium-90 activity in the filtrate was reduced by a factor of 26 to less than 10 3 d/m/ml versus a goal of less than 10 4 d/m/ml; and (4) the concentrated precipitate was washed to a final sodium ion concentration of 0.15 M, well below the 0.225 M upper limit for DWPF feed. These accomplishments were achieved on schedule and without incident. Total radiation exposure to personnel was less than 350 mrem and resulted primarily from sampling precipitate slurry inside tank 48. 3 references, 6 figures, 2 tables

  10. Latest results from Daya Bay

    Science.gov (United States)

    Vorobel, Vit; Daya Bay Collaboration

    2017-07-01

    The Daya Bay Reactor Neutrino Experiment was designed to measure θ 13, the smallest mixing angle in the three-neutrino mixing framework, with unprecedented precision. The experiment consists of eight functionally identical detectors placed underground at different baselines from three pairs of nuclear reactors in South China. Since Dec. 2011, the experiment has been running stably for more than 4 years, and has collected the largest reactor anti-neutrino sample to date. Daya Bay is able to greatly improve the precision on θ 13 and to make an independent measurement of the effective mass splitting in the electron antineutrino disappearance channel. Daya Bay can also perform a number of other precise measurements, such as a high-statistics determination of the absolute reactor antineutrino flux and spectrum, as well as a search for sterile neutrino mixing, among others. The most recent results from Daya Bay are discussed in this paper, as well as the current status and future prospects of the experiment.

  11. EFTF cobalt test assembly results

    International Nuclear Information System (INIS)

    Rawlins, J.A.; Wootan, D.W.; Carter, L.L.; Brager, H.R.; Schenter, R.E.

    1988-01-01

    A cobalt test assembly containing yttrium hydride pins for neutron moderation was irradiated in the Fast Flux Test Facility during Cycle 9A for 137.7 equivalent full power days at a power level fo 291 MW. The 36 test pins consisted of a batch of 32 pins containing cobalt metal to produce Co-60, and a set of 4 pins with europium oxide to produce Gd-153, a radioisotope used in detection of the bone disease Osteoporosis. Post-irradiation examination of the cobalt pins determined the Co-60 produced with an accuracy of about 5 %. The measured Co-60 spatially distributed concentrations were within 20 % of the calculated concentrations. The assembly average Co-60 measured activity was 4 % less than the calculated value. The europium oxide pins were gamma scanned for the europium isotopes Eu-152 and Eu-154 to an absolute accuracy of about 10 %. The measured europium radioisotpe anc Gd-153 concentrations were within 20 % of calculated values. In conclusion, the hydride assembly performed well and is an excellent vehicle for many Fast Flux Test Facility isotope production applications. The results also demonstrate that the calculational methods developed by the Westinghouse Hanford Company are very accurate. (author)

  12. Integration process and logistics results

    International Nuclear Information System (INIS)

    2004-01-01

    The Procurement and Logistics functions have gone through a process of integration since the beginning of integrated management of Asco and Vandellos II up to the present. These are functions that are likely to be designed for delivering a single product to the rest of the organization, defined from a high level of expectations, and that admit simplifications and materialization of synergy's as they are approached from an integrated perspective. The analyzed functions are as follows: Service and Material Purchasing, Warehouse and Material Management, and Documentation and General Services Management. In all case, to accomplish the integration, objectives, procedures and information systems were unified. As for the organization, a decision was made in each case on whether or not to out source. The decisive corporate strategy to integrate, resulting in actions such as moving corporate headquarters to Vandellos II, corporate consolidation, regulation of employment and implementation of the ENDESA Group Economic Information System (SIE) , has shaped this process, which at present can be considered as practically complete. (Author)

  13. PTAC driving safety survey results

    Energy Technology Data Exchange (ETDEWEB)

    Lloyd, E. [Petroleum Technology Alliance Canada, Calgary, AB (Canada)

    2005-07-01

    The results of a survey conducted by the Petroleum Technology Alliance Canada were presented. The survey identified ways in which companies in the oil and gas industry can reduce the potential for vehicle incidents, as well as improve fleet management techniques. Respondents provided a list of over 60 relevant technologies with high potential for application. Top driving safety challenges included adverse weather and road conditions, as well as driver attitude and awareness. Driver speed and fatigue were also seen as significant challenges, as well as encounters with wildlife and road conditions. Poor site conditions were also identified as a challenge, along with poor hazard recognition training, and lack of experience. A total of 157 representatives responded, whose fleets collectively drive approximately 136,500,000 km per year. The fleets totalled 15,800 vehicles. Respondents' affiliations with the oil and gas industry were included, as well as ownership classifications and company fleet sizes. Total annual fleet kilometers were presented, as well as the number of incidents per company per year, along with the number of respondents' animal strikes per year. tabs, figs.

  14. LSND results and their implications

    International Nuclear Information System (INIS)

    Caldwell, D.O.

    1996-01-01

    The combined 1993, 1994, and 1995 data from the LSND experiment shows a statistically compelling excess of events of the type expected for ν μ →ν e neutrino oscillations. An electron between 36 and 60 MeV is identified by Cherenkov and scintillation light from ν e p→e + n, and if a γ is tightly constrained to be correlated with it from np→dγ (2.2 MeV), then 22 such events are observed, but only 4.6±0.6 are expected from background. The probability that this is a fluctuation is -7 . If subsequent analysis shows a similar effect from the independent channel ν μ →ν e , then this would imply a neutrino mass difference which would contribute significantly to the dark matter of the universe. Explaining also the solar and atmospheric neutrino deficits results in a neutrino mass pattern which gives a cold + hot dark matter which fits the structure of the universe on all scales and requires a critical density universe and an universe age compatible with that of the oldest stars. This mass pattern involves a sterile neutrino, evidence for which may come from the need for it in producing heavy elements by supernovae and for blowing off the supernova mantle. (author) 3 figs., 18 refs

  15. Results of the 2009 elections

    CERN Multimedia

    Association du personnel

    The elections to renew the Staff Council for the 2010-2011 period are now behind us and we are very pleased to have had at least as many candidates as posts in five of the six electoral colleges. Furthermore, the average rate of participation of 56.8% in these elections is a very good result compared to previous years. We thank the candidates who have committed themselves to actively defending the interests of the staff, and all our members have shown, by voting, their full support of the candidates in their college and Department. This newly-elected Staff Council (see its composition on the following page) will therefore be truly representative of all the sectors and professions of the Organization, which will be a major asset when the Staff Association representatives begin discussions with the Management and Member States in 2010 on the key issues of the five-yearly review and the measures to be taken to absorb the deficit of our Pension Fund. Armed with this vote of confidence, we know that we can count o...

  16. Experimental results on evaporation waves

    Science.gov (United States)

    Grana Otero, Jose; Parra Fabian, Ignacio

    2010-11-01

    A liquid contained in a vertical glass tube is suddenly depressurized from a high initial pressure down to one for which the stable state is vapour, so vaporization sets off at the free surface. For large enough evaporation rates, the planar vapour-liquid interface is Darrieus-Landau unstable [1], leading to the interface surface rippling close to the instability threshold. Further increasing the initial to final pressure ratio brings about evaporation waves [2,3], in which a highly corrugated front propagates downwards into the liquid. A new experimental method is presented as well as some experimental results obtained by tracking the evolution of the front with a high speed camera. In addition, a number of new phenomena related to the dynamics of bubbles growth at the walls has been uncovered. In particular, a new mode of propagation of the evaporation front is found. In this mode the front originates from below the interface, so the propagation is upwards against gravity with a curved but smooth front.[4pt] [1] F. J. Higuera, Phys. Fluids, V. 30, 679 (1987).[0pt] [2] J.E.Shepherd and B.Sturtevant, J.Fluid Mech., V.121,379 (1982).[0pt] [3] P.Reinke and G.Yadigaroglu, Int.J.Multiph. Flow, V.27,1487 (2001).

  17. Uncertainty of dustfall monitoring results

    Directory of Open Access Journals (Sweden)

    Martin A. van Nierop

    2017-06-01

    Full Text Available Fugitive dust has the ability to cause a nuisance and pollute the ambient environment, particularly from human activities including construction and industrial sites and mining operations. As such, dustfall monitoring has occurred for many decades in South Africa; little has been published on the repeatability, uncertainty, accuracy and precision of dustfall monitoring. Repeatability assesses the consistency associated with the results of a particular measurement under the same conditions; the consistency of the laboratory is assessed to determine the uncertainty associated with dustfall monitoring conducted by the laboratory. The aim of this study was to improve the understanding of the uncertainty in dustfall monitoring; thereby improving the confidence in dustfall monitoring. Uncertainty of dustfall monitoring was assessed through a 12-month study of 12 sites that were located on the boundary of the study area. Each site contained a directional dustfall sampler, which was modified by removing the rotating lid, with four buckets (A, B, C and D installed. Having four buckets on one stand allows for each bucket to be exposed to the same conditions, for the same period of time; therefore, should have equal amounts of dust deposited in these buckets. The difference in the weight (mg of the dust recorded from each bucket at each respective site was determined using the American Society for Testing and Materials method D1739 (ASTM D1739. The variability of the dust would provide the confidence level of dustfall monitoring when reporting to clients.

  18. Stapedectomy in tympanosclerosis, hearing results

    International Nuclear Information System (INIS)

    Al-Qahtani, M.; Hagr, A.

    2008-01-01

    The aim of present study was to evaluate the results of using stapedectomy to treat tympanosclerosis fixation of footplate. It is a retrospective review of tympanosclerosis of the oval window with stapes fixation, after undergoing surgery. Eight patients underwent stapedectomy for tympanosclerotic stapes. Postoperative post-op air-bone gap ABG closure to within 10 dB was achieved in 25% of the cases. An ABG of less than 20 db was obtained in 87.5% of the cases. The mean preoperative pre-op ABGs were 31.09 dB. Significant post-op improvement of air conduction thresholds more than, or equal to 20dB was found in 62.5% of cases. No significant sensorineural hearing loss was seen in this series with a mean pre-op bone-conduction threshold BC of 23.43 dB and a mean post-op BC threshold of 16.25 dB. The mean follow-up period was 6.5 months. (author)

  19. Cyclonic valve test: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Monteiro, Andre Sampaio; Moraes, Carlos Alberto C.; Marins, Luiz Philipe M.; Soares, Fabricio; Oliveira, Dennis; Lima, Fabio Soares de; Airao, Vinicius [Petroleo Brasileiro S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil); Ton, Tijmen [Twister BV, Rijswijk (Netherlands)

    2012-07-01

    For many years, the petroleum industry has been developing a valve that input less shear to the flow for a given required pressure drop and this can be done using the cyclonic concept. This paper presents a comparison between the performances of a cyclonic valve (low shear) and a conventional globe valve. The aim of this work is to show the advantages of using a cyclonic low shear valve instead of the commonly used in the primary separation process by PETROBRAS. Tests were performed at PETROBRAS Experimental Center (NUEX) in Aracaju/SE varying some parameters: water cut; pressure loss (from 4 kgf/cm2 to 10 kgf/cm2); flow rates (30 m3/h and 45 m3/h). Results indicates a better performance of the cyclonic valve, if compared with a conventional one, and also that the difference of the performance, is a function of several parameters (emulsion stability, water content free, and oil properties). The cyclonic valve tested can be applied as a choke valve, as a valve between separation stages (for pressure drop), or for controlling the level of vessels. We must emphasize the importance to avoid the high shear imposed by conventional valves, because once the emulsion is created, it becomes more difficult to break it. New tests are being planned to occur in 2012, but PETROBRAS is also analyzing real cases where the applications could increase the primary process efficiency. In the same way, the future installations are also being designed considering the cyclonic valve usage. (author)

  20. Majorana Thermosyphon Prototype Experimental Results

    International Nuclear Information System (INIS)

    Fast, James E.; Reid, Douglas J.; Aguayo Navarrete, Estanislao

    2010-01-01

    The Majorana demonstrator will operate at liquid Nitrogen temperatures to ensure optimal spectrometric performance of its High Purity Germanium (HPGe) detector modules. In order to transfer the heat load of the detector module, the Majorana demonstrator requires a cooling system that will maintain a stable liquid nitrogen temperature. This cooling system is required to transport the heat from the detector chamber outside the shield. One approach is to use the two phase liquid-gas equilibrium to ensure constant temperature. This cooling technique is used in a thermosyphon. The thermosyphon can be designed so the vaporization/condensing process transfers heat through the shield while maintaining a stable operating temperature. A prototype of such system has been built at PNNL. This document presents the experimental results of the prototype and evaluates the heat transfer performance of the system. The cool down time, temperature gradient in the thermosyphon, and heat transfer analysis are studied in this document with different heat load applied to the prototype.

  1. Double Chooz: Results and Perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Franke, A.J., E-mail: ajfranke@nevis.columbia.edu [Columbia University, New York, New York 10027 (United States)

    2013-04-15

    The Double Chooz experiment has been observing ν{sup ¯}{sub e} from two reactor cores at the Chooz nuclear power station in Ardennes, France, with a single 10.3 m{sup 3} fiducial volume Gd-doped liquid scintillator detector at a flux-weighted average baseline of ∼1050 m. This article reviews results achieved with a detector live time of 227.93 days and exposure of 33.71 GW-ton-years. A total of 8,249 candidate ν{sup ¯}{sub e} events have been observed, compared to an expected 8,937 events in the null-oscillation case: this deficit is interpreted as evidence for ν{sup ¯}{sub e} disappearance. A fit to the observed neutrino rate and spectral shape gives a best-fit value of sin{sup 2}(2θ{sub 13})=0.109±0.030(stat.)±0.025(syst.) at a mass-squared splitting of Δm{sub 31}{sup 2}=2.32×10{sup −3} eV{sup 2}. The null-oscillation hypothesis is excluded by the data at 99.8% CL (2.9σ). The Double Chooz Near Detector is under construction, and analysis efforts to measure neutrino directionality, test Lorentz violation, and measure backgrounds in situ are underway.

  2. Double Chooz: Results and Perspectives

    Science.gov (United States)

    Franke, A. J.

    2013-04-01

    The Double Chooz experiment has been observing ν from two reactor cores at the Chooz nuclear power station in Ardennes, France, with a single 10.3 m fiducial volume Gd-doped liquid scintillator detector at a flux-weighted average baseline of ˜1050 m. This article reviews results achieved with a detector live time of 227.93 days and exposure of 33.71 GW-ton-years. A total of 8,249 candidate ν events have been observed, compared to an expected 8,937 events in the null-oscillation case: this deficit is interpreted as evidence for ν disappearance. A fit to the observed neutrino rate and spectral shape gives a best-fit value of sin2(2θ13)=0.109±0.030 (stat.)±0.025 (syst.) at a mass-squared splitting of Δm312=2.32×10-3 eV. The null-oscillation hypothesis is excluded by the data at 99.8% CL (2.9σ). The Double Chooz Near Detector is under construction, and analysis efforts to measure neutrino directionality, test Lorentz violation, and measure backgrounds in situ are underway.

  3. Comparison of airtightness retesting results

    Energy Technology Data Exchange (ETDEWEB)

    1989-01-01

    Polyethylene vapour barrier and airtight drywall are two methods used by the building industry to reduce air leakage in residential homes. Concern has been expressed that polyethylene air/vapour barriers degrade over time. This concern has led various agencies to test and retest homes for air leakage. This report is the compilation of the data collected as a result of that testing. Raw data were collected on 145 homes from various sources. Data were screened and the tests of homes were omitted from the analysis if the fan tests were done on the same house by different firms, if the construction of the house was not sufficiently complete, or if the initial air change rate per hour (ACH) was greater than 3. With these omissions from the database, 90 homes remained to be analyzed. The 90 homes were separated into two groups, those with an initial ACH less than 1.5 and those with an initial ACH between 1.5 and 3.0. The data were recorded in two tables which included the ACH, the time in months, the percentage change, and the difference in change between the first test and each subsequent test. These data indicate a relatively minor average change in airtightness. Keeping in mind the quantity of data collected the time period examined, there is no indication that significant problems exist that would necessitate a change to the current building practice. 2 figs., 5 tabs.

  4. Excellent results for CERN runners

    CERN Multimedia

    Hervé Cornet, CERN Running club

    2015-01-01

    As in previous years, thirty or so runners from CERN took part in the Tour du Canton de Genève (more information here, in French only).   The men’s team that won the corporate challenge prize in the Tour du Canton de Genève: (standing, left to right) Patrick Villeton, Phil Hebda, Mika Vesterinen, Steffen Doebert; (sitting, left to right) Guillaume Michet and Camille Ruiz-Llamas. The Laboratory was represented in the corporate challenge by five teams, one of which came first in the men’s category. CERN’s other teams also put in good performances, with one finishing fourth in the men's category and another seventh in the mixed category. Runners from CERN did well in the individual classifications too. All the results can be found here. The Maxi Race team: (left to right) Sebastien Ponce, Alain Cauphy, Klaus Hanke and Christophe Biot. Elsewhere, four CERN runners competed in the finals of the Annecy Maxi Race (site in French only...

  5. LSND results and their implications

    Energy Technology Data Exchange (ETDEWEB)

    Caldwell, D O [California Univ., Santa Barbara, CA (United States). Dept. of Physics

    1996-11-01

    The combined 1993, 1994, and 1995 data from the LSND experiment shows a statistically compelling excess of events of the type expected for {nu}{sub {mu}} {yields}{nu}{sub e} neutrino oscillations. An electron between 36 and 60 MeV is identified by Cherenkov and scintillation light from {nu}{sub e}p{yields}e{sup +}n, and if a {gamma} is tightly constrained to be correlated with it from np{yields}d{gamma} (2.2 MeV), then 22 such events are observed, but only 4.6{+-}0.6 are expected from background. The probability that this is a fluctuation is <10{sup -7}. If subsequent analysis shows a similar effect from the independent channel {nu}{sub {mu}}{yields}{nu}{sub e}, then this would imply a neutrino mass difference which would contribute significantly to the dark matter of the universe. Explaining also the solar and atmospheric neutrino deficits results in a neutrino mass pattern which gives a cold + hot dark matter which fits the structure of the universe on all scales and requires a critical density universe and an universe age compatible with that of the oldest stars. This mass pattern involves a sterile neutrino, evidence for which may come from the need for it in producing heavy elements by supernovae and for blowing off the supernova mantle. (author) 3 figs., 18 refs.

  6. CMS results in Electroweak Physics

    CERN Multimedia

    CERN. Geneva

    2011-01-01

    We present the results of electroweak studies performed using data collected in 2010 at a center-of-mass energy of 7 TeV by the CMS experiment at the LHC. Besides their intrinsic interest as unique samples to calibrate and understand the CMS detector response to leptons, jets and missing energy, events containing W and Z bosons appear as dominant components in many Higgs seaches and in most of the searches beyond the Standard Model, either as signal or as background. In addition, the excellent level of theoretical and experimental understanding of these processes allows electroweak tests at the LHC at an unprecendented level of precision. CMS uses a wide range of final states to measure cross sections, asymmetries, polarizations and differential distributions in general. The current integrated luminosity is already sufficient to perform not just inclusive measurements using W and Z decays into muons and electrons, but also precise studies of associated jet production and final states containing taus, as well...

  7. Our Results in Penile Fractures

    Directory of Open Access Journals (Sweden)

    Tufan Süelözgen

    2016-06-01

    Full Text Available Introduction Penile fracture is a urological emergency caused by direct trauma to an erected penis, tearing the tunica albuginea in the corpus cavernosum. The preferred treatment method is draining the hematoma and surgical repair of tunica albuginea tear as soon as possible following diagnosis. Materials and Methods Forty-nine patients who were diagnosed with penile fracture between January 2009 and December 2014 were reviewed. Physical examination was performed to see the extent of penile hematoma, the side of the penile curvature and the presence of blood in the external meatus. Two patients who were diagnosed with urethrorrhagia underwent retrograde urethrogram for urethral injury. In all patients, penile skin was peeled using a circular subcoronal degloving incision and tunica tear was repaired using absorbable suture materials. The patients were then followed for painful erections, penile deformities and erection angles. Results The average age of the 49 patients, who were included in the study, was 36.5 years (21-65. In their etiological questioning, most patients reported the fracture occurring during sexual intercourse. Retrograde urethrography was indicated in 2 patients with blood in the external meatus and were diagnosed with urethral injury. The patients were taken to emergency surgery. Tunica defects varied between 1 and 2 cm. Incomplete urethral injuries were primarily repaired around 18 French Foley catheter. None of the patients reported penile deformity or painful erections. Their erection angles were found to be within the normal range. Conclusion Even though it is a relatively rare condition, penile fractures are so important that might cause serious complications when not treated surgically. A thorough anamnesis and physical examination suffice for diagnosis.

  8. Public Administration reforms and results

    Directory of Open Access Journals (Sweden)

    Gunnar Helgi Kristinsson

    2014-12-01

    Full Text Available Research on administrative reforms during the past thirty years indicates that reform efforts of countries differ. The Anglo Saxon states were at the forefront of the New Public Management movement while countries on mainland Europe were more hesitant and moved further towards the Neo-Weberian state. Academics have tried to explain different reform efforts within countries by looking at political, historical and cultural issues, values and economic factors to name just a few. Three hypotheses are put forward to explain reform efforts in different states. This research involves analysing the implementation of two different reform trends, New Public Management and the Neo-Weberian tradition. The analysis indicates that countries vary in their commitment to reform rather than in the emphasis on either New Public Management or the Neo-Weberian State. Decentralization, clear objectives and consultation with communities and experts are closely related to national reform efforts. However, Iceland does distinguish itself from Europe and the Nordic countries. The analysis reveals that although decentralization is high in the Icelandic system, autonomy of agencies does not have a strong relation to a varied use of administrative instruments. The second part of the article focuses on the results and achievements of reform programmes. The achievement of reform programmes are examined in relation to theories of bounded rationality, street level bureaucracy (bottom up and consensus decision making. Three hypotheses are presented and tested to explain what causes reforms programmes to be successful in some countries and not in others. The analysis reveals that countries are more likely to succeed if bounded rationality is applied with careful preparation and when stakeholders are consulted.

  9. 'Orion-2': first scientific results

    International Nuclear Information System (INIS)

    Gurzadyan, G.A.

    1975-01-01

    The first results of proceeding some data collected by the 'Orion-2' observatory set up in the 'Soyuz-13' are presented. The goal of the experiment is to get the photographs of ultraviolet (UV) spectra of weak stars in the range of 2000-5000 A. Spectrograms are obtained for stars with brightness of 9-9.5 stellar magnitude at 1.5 min exposure. It has been possible to take spectrograms of many stars weaker than the 12-th magnitude at the 18 min exposure and at the short-wave boundary of a spectrum of 2500 A. A group of stars of an unknown type has been observed not far from Capella. The group contains approximately twenty stars weaker than the 10-th photographic magnitude. The average position of the group is α=0.5sup(m)10sup(m), delta=+44deg30'. Spectrograms of more than twenty hot stars in the Sails constellation in the South Sky are obtained. According to the 'Orion-2' data the light absorption in the interstellar space in the range of 2000-3000 A is caused by graphite particles of an almost spheric shape, that is in accordance with present assumptions. In spectra of over 100 stars the doublet of ionized magnesium, 2800 Mg 2, has been distinguished and measured. Spectral photographs made by the 'Orion-2' allow one to reveal chromosphere of cool stars. A strange star is discovered (12sup(m),6 brigthness in photographic rays) not far from Capella, its spectrum displaying many emission lines. A unique spectrogram of the NGC 2 2149 planetary nebula and its nucleus has been obtained. The question is whether it is possible to classify stars not only by their lines but also by the continuous UV spectrum up to 2000 A. This method may turn out to be very effective for weak stars. The 'Orion-2' has demonstrated ample possibilities of carrying out astrophysical researches outside the atmosphere

  10. Mobile evaporator corrosion test results

    International Nuclear Information System (INIS)

    Rozeveld, A.; Chamberlain, D.B.

    1997-05-01

    Laboratory corrosion tests were conducted on eight candidates to select a durable and cost-effective alloy for use in mobile evaporators to process radioactive waste solutions. Based on an extensive literature survey of corrosion data, three stainless steel alloys (304L, 316L, AL-6XN), four nickel-based alloys (825, 625, 690, G-30), and titanium were selected for testing. The corrosion tests included vapor phase, liquid junction (interface), liquid immersion, and crevice corrosion tests on plain and welded samples of candidate materials. Tests were conducted at 80 degrees C for 45 days in two different test solutions: a nitric acid solution. to simulate evaporator conditions during the processing of the cesium ion-exchange eluant and a highly alkaline sodium hydroxide solution to simulate the composition of Tank 241-AW-101 during evaporation. All of the alloys exhibited excellent corrosion resistance in the alkaline test solution. Corrosion rates were very low and localized corrosion was not observed. Results from the nitric acid tests showed that only 316L stainless steel did not meet our performance criteria. The 316L welded interface and crevice specimens had rates of 22.2 mpy and 21.8 mpy, respectively, which exceeds the maximum corrosion rate of 20 mpy. The other welded samples had about the same corrosion resistance as the plain samples. None of the welded samples showed preferential weld or heat-affected zone (HAZ) attack. Vapor corrosion was negligible for all alloys. All of the alloys except 316L exhibited either open-quotes satisfactoryclose quotes (2-20 mpy) or open-quotes excellentclose quotes (<2 mpy) corrosion resistance as defined by National Association of Corrosion Engineers. However, many of the alloys experienced intergranular corrosion in the nitric acid test solution, which could indicate a susceptibility to stress corrosion cracking (SCC) in this environment

  11. Recent results in visual servoing

    Science.gov (United States)

    Chaumette, François

    2008-06-01

    Visual servoing techniques consist in using the data provided by a vision sensor in order to control the motions of a dynamic system. Such systems are usually robot arms, mobile robots, aerial robots,… but can also be virtual robots for applications in computer animation, or even a virtual camera for applications in computer vision and augmented reality. A large variety of positioning tasks, or mobile target tracking, can be implemented by controlling from one to all the degrees of freedom of the system. Whatever the sensor configuration, which can vary from one on-board camera on the robot end-effector to several free-standing cameras, a set of visual features has to be selected at best from the image measurements available, allowing to control the degrees of freedom desired. A control law has also to be designed so that these visual features reach a desired value, defining a correct realization of the task. With a vision sensor providing 2D measurements, potential visual features are numerous, since as well 2D data (coordinates of feature points in the image, moments, …) as 3D data provided by a localization algorithm exploiting the extracted 2D measurements can be considered. It is also possible to combine 2D and 3D visual features to take the advantages of each approach while avoiding their respective drawbacks. From the selected visual features, the behavior of the system will have particular properties as for stability, robustness with respect to noise or to calibration errors, robot 3D trajectory, etc. The talk will present the main basic aspects of visual servoing, as well as technical advances obtained recently in the field inside the Lagadic group at INRIA/INRISA Rennes. Several application results will be also described.

  12. Corral Monitoring System assessment results

    International Nuclear Information System (INIS)

    Filby, E.E.; Haskel, K.J.

    1998-03-01

    This report describes the results of a functional and operational assessment of the Corral Monitoring Systems (CMS), which was designed to detect and document accountable items entering or leaving a monitored site. Its development was motivated by the possibility that multiple sites in the nuclear weapons states of the former Soviet Union might be opened to such monitoring under the provisions of the Strategic Arms Reduction Treaty. The assessment was performed at three levels. One level evaluated how well the planned approach addressed the target application, and which involved tracking sensitive items moving into and around a site being monitored as part of an international treaty or other agreement. The second level examined the overall design and development approach, while the third focused on individual subsystems within the total package. Unfortunately, the system was delivered as disassembled parts and pieces, with very poor documentation. Thus, the assessment was based on fragmentary operating data coupled with an analysis of what documents were provided with the system. The system design seemed to be a reasonable match to the requirements of the target application; however, important questions about site manning and top level administrative control were left unanswered. Four weaknesses in the overall design and development approach were detected: (1) poor configuration control and management, (2) inadequate adherence to a well defined architectural standard, (3) no apparent provision for improving top level error tolerance, and (4) weaknesses in the object oriented programming approach. The individual subsystems were found to offer few features or capabilities that were new or unique, even at the conceptual level. The CMS might possibly have offered a unique combination of features, but this level of integration was never realized, and it had no unique capabilities that could be readily extracted for use in another system

  13. Corral Monitoring System assessment results

    Energy Technology Data Exchange (ETDEWEB)

    Filby, E.E.; Haskel, K.J.

    1998-03-01

    This report describes the results of a functional and operational assessment of the Corral Monitoring Systems (CMS), which was designed to detect and document accountable items entering or leaving a monitored site. Its development was motivated by the possibility that multiple sites in the nuclear weapons states of the former Soviet Union might be opened to such monitoring under the provisions of the Strategic Arms Reduction Treaty. The assessment was performed at three levels. One level evaluated how well the planned approach addressed the target application, and which involved tracking sensitive items moving into and around a site being monitored as part of an international treaty or other agreement. The second level examined the overall design and development approach, while the third focused on individual subsystems within the total package. Unfortunately, the system was delivered as disassembled parts and pieces, with very poor documentation. Thus, the assessment was based on fragmentary operating data coupled with an analysis of what documents were provided with the system. The system design seemed to be a reasonable match to the requirements of the target application; however, important questions about site manning and top level administrative control were left unanswered. Four weaknesses in the overall design and development approach were detected: (1) poor configuration control and management, (2) inadequate adherence to a well defined architectural standard, (3) no apparent provision for improving top level error tolerance, and (4) weaknesses in the object oriented programming approach. The individual subsystems were found to offer few features or capabilities that were new or unique, even at the conceptual level. The CMS might possibly have offered a unique combination of features, but this level of integration was never realized, and it had no unique capabilities that could be readily extracted for use in another system.

  14. FIRST RESULTS FROM OEDOTENSIOMETRIC TESTS

    Directory of Open Access Journals (Sweden)

    Luigi Cavazza

    2008-09-01

    Full Text Available An oedotensiometer was used to examine to examine the behaviour of sieved sample of a swelling soil (a vertisol as well as of the same soils treated with solution of Na+ + Ca2+ to simulate the soil changes from excessive irrigation with brackish water. The oedometer test consisted in an infiltration of water from below through a ceramic porous plate at a feeding pressure of +10 cm water and successive drainage under a depression mostly of -112 cm of water. The rate of water entry as well as the swelling rate of the sample were monitored. Preliminary considerations regards the domains in which the shrinkage curve of a swelling soil is subdivided and make hypothesis on the swelling process expected when the infiltration from below of the sample is applied. The results support the hypothesis that when the water pressure is applied some water enters rather rapidly in the larger structural pores and is followed later by the swelling in the smaller pores, responsible for the basic domain. This first conclusion demonstrates that the assumption of a simultaneous movement of solid and liquid components in the sample, which is the base of most theoretical developments for swelling soils, cannot be accepted for the tested samples. Some cases with water clogging on the sample surface confirm a late final swelling of the soil and permitted to evaluate the hydraulic conductivity of the swollen soil. These manifestations are more evident in sodicated soils. The loading of the sample reduces the swelling of the sample and seems to reduce its permeability. The reduction of the feeding water pressure further reduces the sample swelling. The draining process from saturated soil sample shows that most of the process occurs in the large pores of the structural domain. This gives the possibility to evaluate the water diffusivity coefficient for the structural domain of the sample. In draining the soil with the highest sodication there was a variation of soil volume

  15. ARTIST: introduction and first results

    International Nuclear Information System (INIS)

    Guentay, S.; Suckow, D.; Dehbi, A.; Kapulla, R.

    2004-01-01

    Aerosol Trapping In a Steam Generator (ARTIST) is a seven-phase international project (2003-2007) which investigates aerosol and droplet retention in a model steam generator under dry, wet and accident management conditions, respectively. The test section is comprised of a scaled steam generator tube bundle consisting of 270 tubes and three stages, one 1:1 separator unit, and one 1:1 dryer unit. As a prelude to the ARTIST project, four tests are conducted in the ARTIST bundle within the 5th EU FWP SGTR. These first tests address aerosol deposition phenomena on two different scales: near the tube break, where the gas velocities are sonic, and far away from the break, where the flow velocities are three orders of magnitude lower. With a dry bundle and the full flow representing the break stage conditions, there is strong evidence that the TiO 2 aerosols used (AMMD 2-4 μm, 32 nm primary particles) disintegrate into much smaller particles because of the sonic conditions at the break, hence promoting particle escape from the secondary and lowering the overall DF, which is found to be between 2.5 and 3. With a dry bundle and a small flow reproducing the far-field velocities, the overall bundle DF is of the order of 5, implying a DF of about 1.9 per stage. Extrapolating the results of the dry tests, it turns out that for steam generators with nine or more stages, it is expected that substantial DF's could be achieved when the break is located near the tube sheet region. In addition, better decontamination is expected using more representative proxies of severe accident aerosols (sticky, multi-component particles), a topic which is yet to be investigated. When the bundle is flooded, the DF is between 45 and 5740, depending on the mass flow rate, the steam content, and the water submergence. The presence of steam in the carrier gas and subsequent condensation inside the broken tube causes aerosol deposition and blockages near the break, leading to an increase in the

  16. ARTIST: introduction and first results

    International Nuclear Information System (INIS)

    Guntay, S.; Suckow, D.; Dehbi, A.; Kapulla, R.

    2004-01-01

    ARTIST (Aerosol Trapping In a Steam Generator) is an international project which investigates aerosol and droplet retention in a model steam generator under dry, wet and accident management conditions, respectively. The test section comprises a scaled steam generator tube bundle consisting of 270 tubes and 3 stages, one 1:1 separator unit, and one 1:1 dryer unit. As a prelude to the ARTIST project, four tests are conducted in the ARTIST bundle. These first tests address aerosol deposition phenomena on two different scales: near the tube break, where the gas velocities are sonic, and far away from the break, where the flow velocities are 3 orders of magnitude lower. With a dry bundle and the full flow representing the break stage conditions, there is strong evidence that the TiO 2 aerosols used (AMMD 2-4 μm, 32 nm primary particles) disintegrate into much smaller particles because of the sonic conditions at the break, hence promoting particle escape from the secondary and lowering the overall decontamination factor (DF), which is found to be between 2.5 and 3. With a dry bundle and a small flow reproducing the far-field velocities, the overall bundle DF is of the order of 5, implying a DF of about 1.9 per stage. Extrapolating the results of the dry tests, it turns out that for steam generators with 9 or more stages, it is expected that substantial DFs could be achieved when the break is located near the tube sheet region. In addition, better decontamination is expected using more representative proxies of severe accident aerosols (sticky, multicomponent particles), a topic which is yet to be investigated. When the bundle is flooded, the DF is between 45 and 5740, depending on the mass flow rate, the steam content, and the water submergence. The presence of steam in the carrier gas and subsequent condensation inside the broken tube causes aerosol deposition and blockages near the break, leading to an increase in the primary pressure. This has implications for real

  17. First half 2010 financial results

    International Nuclear Information System (INIS)

    2010-01-01

    The Supervisory Board of the AREVA group presents in this document the financial statements submitted by the Executive Board for the semester ended June 30, 2010. Areva backlog continued to rise in the first half of the year. Areva's revenue is up by more than 6% for the first six months to more than 4 billion euros. The performance of Areva's recurring business continues to improve, reflecting optimization plans deployed in all of the group's business units. However, Areva booked in the first half a non cash reversible accounting adjustment on the value of certain mining assets, following the publication in the second quarter of new prospective data on uranium prices, as well as an additional provision on the EPR project in Finland. Cumulated provisions on OL3 rose to 2.6 billion euros. Capitalizing on lessons learned from this project, Areva has reduced strongly the engineering hours needed for the completion of the nuclear steam supply system for the Taishan 1 and 2 EPR reactors. Net income attributable to owners of the parent rose to 843 million euros, including the 1.3 billion euro gain on the disposal of the Transmission and Distribution business, or 23.82 euros per share. For the full year of 2010, the group anticipates a substantial revenue and backlog growth, an increase in operating income excluding particular items, a negative operating income, and a strong increase in net income attributable to owners of the parent, which includes the capital gain on disposal of the Transmission and Distribution business. First half 2010 financial results in brief: - Backlog of euro 44.1 bn: +euro 1.2 bn compared with June 30, 2009; - Revenue of euro 4.158 bn: +6.4% compared with first half 2009; - Operating income excl. particular items: euro 213 m, for a 5.1% margin; - Operating income: -euro 485 m; - Net income group share: euro 843 m including the euro 1.27 bn gain on the sale of the T and D business; - Earnings per share: euro 23.82; - Net debt of euro 5.152 bn

  18. 1999 Annual report -- Generating results

    International Nuclear Information System (INIS)

    2000-01-01

    results and a consolidated financial statement, with the usual supporting information attached

  19. Localization of Myosin and Actin in the Pelage and Whisker Hair Follicles of Rat

    International Nuclear Information System (INIS)

    Morioka, Kiyokazu; Matsuzaki, Toshiyuki; Takata, Kuniaki

    2006-01-01

    The combined effects of myosin II and actin enable muscle and nonmuscle cells to generate forces required for muscle contraction, cell division, cell migration, cellular morphological changes, the maintenance of cellular tension and polarity, and so on. However, except for the case of muscle contraction, the details are poorly understood. We focus on nonmuscle myosin and actin in the formation and maintenance of hair and skin, which include highly active processes in mammalian life with respect to the cellular proliferation, differentiation, and movement. The localization of nonmuscle myosin II and actin in neonatal rat dorsal skin, mystacial pad, hair follicles, and vibrissal follicles was studied by immunohistochemical technique to provide the basis for the elucidation of the roles of these proteins. Specificities of the antibodies were verified by using samples from the relevant tissues and subjecting them to immunoblotting test prior to morphological analyses. The myosin and actin were abundant and colocalized in the spinous and granular layers but scarce in the basal layer of the dorsal and mystacial epidermis. In hair and vibrissal follicles, nonmuscle myosin and actin were colocalized in the outer root sheath and some hair matrix cells adjoining dermal papillae. In contrast, most areas of the inner root sheath and hair matrix appeared to comprise very small amounts of myosin and actin. Hair shaft may comprise significant myosin during the course of its keratinization. These results suggest that the actin-myosin system plays a part in cell movement, differentiation, protection and other key functions of skin and hair cells

  20. Distinct functional interactions between actin isoforms and nonsarcomeric myosins.

    Directory of Open Access Journals (Sweden)

    Mirco Müller

    Full Text Available Despite their near sequence identity, actin isoforms cannot completely replace each other in vivo and show marked differences in their tissue-specific and subcellular localization. Little is known about isoform-specific differences in their interactions with myosin motors and other actin-binding proteins. Mammalian cytoplasmic β- and γ-actin interact with nonsarcomeric conventional myosins such as the members of the nonmuscle myosin-2 family and myosin-7A. These interactions support a wide range of cellular processes including cytokinesis, maintenance of cell polarity, cell adhesion, migration, and mechano-electrical transduction. To elucidate differences in the ability of isoactins to bind and stimulate the enzymatic activity of individual myosin isoforms, we characterized the interactions of human skeletal muscle α-actin, cytoplasmic β-actin, and cytoplasmic γ-actin with human myosin-7A and nonmuscle myosins-2A, -2B and -2C1. In the case of nonmuscle myosins-2A and -2B, the interaction with either cytoplasmic actin isoform results in 4-fold greater stimulation of myosin ATPase activity than was observed in the presence of α-skeletal muscle actin. Nonmuscle myosin-2C1 is most potently activated by β-actin and myosin-7A by γ-actin. Our results indicate that β- and γ-actin isoforms contribute to the modulation of nonmuscle myosin-2 and myosin-7A activity and thereby to the spatial and temporal regulation of cytoskeletal dynamics. FRET-based analyses show efficient copolymerization abilities for the actin isoforms in vitro. Experiments with hybrid actin filaments show that the extent of actomyosin coupling efficiency can be regulated by the isoform composition of actin filaments.

  1. Search Results | Page 88 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2010-01-01

    Results 871 - 880 of 8518 ... Research results : analyzing the impact of introducing an automated management information system within microfinance institutions. Published date. January 1, 2010. Studies.

  2. Search Results | Page 72 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2010-01-01

    Results 711 - 720 of 8491 ... Research results : analyzing the impact of introducing an automated management information system within microfinance institutions. Published date. January 1, 2010. Studies.

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    Results 41 - 50 of 163 ... Water Resource Management and the Changing Climate in ... Cambodia's Tonle Sap Lake is the largest freshwater lake in ... These events are resulting in higher economic, social, environmental, and human costs.

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    Results 8411 - 8420 of 8496 ... Land Tenure, Gender, and Globalization: Research and Analysis from ... Globalization, Labor Markets and Inequality in India ... the results of an international initiative to document the effects of how health systems ...

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    Results 7781 - 7790 of 9602 ... Land Tenure, Gender, and Globalization: Research and Analysis from ... Globalization, Labor Markets and Inequality in India ... the results of an international initiative to document the effects of how health systems ...

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    Results 8411 - 8420 of 8491 ... Globalization, Labor Markets and Inequality in India ... results of an international initiative to document the effects of how health systems in ... Natural Resource Management: The Impact of Gender and Social Issues.

  7. First results from Mark III at SPEAR

    International Nuclear Information System (INIS)

    Einsweiler, K.F.

    The paper presents data on meson decays obtained using the MARK III detector operating at SPEAR. Results on hadronic decays; decays of the etasub(e); and results on radiative decays; are all described. (U.K.)

  8. Search Results | Page 710 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 7091 - 7100 of 9601 ... ... and Practice in South Asia : Building a Community of Experts ... Social Psychology in Post Conflict Colombia. Psychosocial trauma resulting from the Colombian armed conflict constitutes a pressing social and ...

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    International Development Research Centre (IDRC) Digital Library (Canada)

    Search Results. Showing 5371 - 5380 of 9604 results. Reports ... Business training for microfinance clients : how it matters and for whom? ... building a regional platform for political engagement and strategic action; final technical report.

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    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 501 - 510 of 1133 ... ... starch industry has resulted in increased disease prevalence, soil erosion, ... Food processing in developing countries is an important component of ... to improve child nutrition and food security in northern Malawi.

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    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 421 - 430 of 1804 ... An investigation into the determinants of business performance in ... where it is associated with economic activity, transportation, and the use of ... many other Asian countries, rapid and unplanned growth has resulted ...

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    International Development Research Centre (IDRC) Digital Library (Canada)

    2009-01-01

    Results 71 - 80 of 132 ... Empowering regulators to protect consumer rights in the ICT sector, Introductory Workshop, Lusaka, 13 August 2009. Published date. January 1, 2009. Reports. EAST AFRICA RESEARCH RESULTS POLICY MAKING ...

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    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 8081 - 8090 of 9602 ... Evaluating IDRC's role at major conferences, events. Over the ... Participatory GIS for resource management in Africa: Taking stock. This ICT4D article series features results from innovative research on participatory ...

  14. Search Results | Page 69 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 681 - 690 of 8531 ... Role of the sea kayak tour guide : mixed methods exploration into the ... from this study did not completely support the survey results, highl ... and institutional foundations within traditional rural communities that can ...

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    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 931 - 940 of 8491 ... ... and institutional foundations within traditional rural communities that can ... Role of the sea kayak tour guide : mixed methods exploration into the ... from this study did not completely support the survey results, highl.

  16. Recent Results from the ATLAS Experiment

    CERN Document Server

    Djama, Fares; The ATLAS collaboration

    2015-01-01

    A selection of recent Run 1 ATLAS results and first preliminary results from Run 2 are shown. Overview plots on Higgs properties, top measurements and SUSY searches are presented as well as recent QCD and electroweak measurements.

  17. Search Results | Page 5 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 41 - 50 of 80 ... Applying ICT for Disaster Mitigation in the Central American ... Central America is subject to frequent climate variability resulting in floods and droughts. ... Accumulated environmental, economic, and social damages to date ...

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    International Development Research Centre (IDRC) Digital Library (Canada)

    Search Results. Showing 7961 - 7970 of 8491 results. Story. Health Natural Resources Mining ECOHEALTH ... CASE STUDY: Latin America — An engine for rural development in Latin America. Research in Action. Biodiversity Gender Crops ...

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    Results 321 - 330 of 420 ... Rapid economic growth in South Asia has not resulted in increased ... the national innovation system and its impact on the economy. ... through simple resource-based activities: oil, minerals, tourism and labour migrati.

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    Results 341 - 350 of 439 ... Rapid economic growth in South Asia has not resulted in increased ... the national innovation system and its impact on the economy. ... through simple resource-based activities: oil, minerals, tourism and labour migrati.

  1. Search Results | Page 88 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Search Results. Showing 871 - 880 of 8491 results. Studies ... Strengthening Nurses' Capacity in HIV Policy Development in Sub-Saharan Africa and the Caribbean ... Novel Epidemiological Method: Using Newspapers To Provide Insight Into ...

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    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 9151 - 9160 of 9580 ... The publication "Practical Guide for producers and farmers: Collective ... assesses the intervention of AGROECO in the field of alternative organic ... The research resulted in documentation of over 100 plants and ...

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    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 8141 - 8150 of 8491 ... ... routinely to illustrate the profound role of information in modern societies. ... worlds, the vital role of higher education in society is accepted. ... This crisis is the result of the breakdown of traditional farming systems.

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    Results 8441 - 8450 of 8494 ... Our chance to share the results of our work with Canadians and to ... structure, robust management processes, effective systems, and internal controls. ... as required under Canada's Financial Administration Act.

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    Search Results. Showing 6411 - 6420 of 9601 results. Project ... STI for Development in Asia : a Platform for Information Sharing and Learning. This project is based on the premise that science, technology and innovation (STI) are critical ...

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    Results 321 - 330 of 439 ... ... result in severe, long-term social and mental health problems for exposed children and adolescents. ... national-level networks in various parts of the word including the ... Women's Participation and Decentralization.

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    Search Results. Showing 7621 - 7630 of 8490 results. Books ... and practice in natural resource management are often depicted as a cyclical and rational process. ... to provide quality education, improve health care, allow open government, ...

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    Results 11 - 16 of 16 ... Under universal systems, health care is paid for in advance, via prepayment ... Research results have no value unless they are made available for due ... Community Based Adaptation to Climate Change in Africa.

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    Results 7181 - 7190 of 9601 ... Research on Business Process Outsourcing ... Rapid economic growth in South Asia has not resulted in increased ... The nature and scale of the problem are not captured by aggregate unemployment statistics.

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    Results 41 - 50 of 1643 ... Global water governance and the rise of the constitutional regulatory state in Colombia. This article interprets the regulatory state in the south as the result of a dialectic process between global governance institutions, ...

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    Results 9111 - 9120 of 9602 ... Trade facilitation and poverty reduction : China-ASEAN region case study. Results show that a 1 per cent increase in port efficiency results in a 1.051 ... is near the world average, but among ASEAN countries there is a big gap. ... The focus of the study is the Economic Corridors and Cross Border ...

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    International Development Research Centre (IDRC) Digital Library (Canada)

    2013-10-01

    Results 51 - 60 of 60 ... Results show that a 1 per cent increase in port efficiency results in a 1.051 per cent decrease in the poverty index. The level of Chinese trade facilitation is near the world average, but among ASEAN countries there is a big gap. Published date. October 1, 2013. Reports. EXPORT ORIENTED ...

  14. Genetic disruption of calpain correlates with loss of membrane blebbing and differential expression of RhoGDI-1, cofilin and tropomyosin

    DEFF Research Database (Denmark)

    Larsen, Anna Karina; Lametsch, Rene; Elce, John S.

    2008-01-01

    Dynamic regulation of the actin cytoskeleton is important for cell motility, spreading and the formation of membrane surface extensions such as lamellipodia, ruffles and blebs. The ubiquitous calpains contribute to integrin-mediated cytoskeletal remodelling during cell migration and spreading, by...

  15. Current advances on polynomial resultant formulations

    Science.gov (United States)

    Sulaiman, Surajo; Aris, Nor'aini; Ahmad, Shamsatun Nahar

    2017-08-01

    Availability of computer algebra systems (CAS) lead to the resurrection of the resultant method for eliminating one or more variables from the polynomials system. The resultant matrix method has advantages over the Groebner basis and Ritt-Wu method due to their high complexity and storage requirement. This paper focuses on the current resultant matrix formulations and investigates their ability or otherwise towards producing optimal resultant matrices. A determinantal formula that gives exact resultant or a formulation that can minimize the presence of extraneous factors in the resultant formulation is often sought for when certain conditions that it exists can be determined. We present some applications of elimination theory via resultant formulations and examples are given to explain each of the presented settings.

  16. Metastasis-associated protein Mts1 (S100A4) inhibits CK2-mediated phosphorylation and self-assembly of the heavy chain of nonmuscle myosin

    DEFF Research Database (Denmark)

    Kriajevska, M; Bronstein, I B; Scott, D J

    2000-01-01

    a regulatory role in the myosin assembly. In the presence of calcium, Mts1 binds at the C-terminal end of the myosin heavy chain close to the site of phosphorylation by protein kinase CK2 (Ser1944). In the present study, we have shown that interaction of Mts1 with the human platelet myosin or C...

  17. Recommended oral sodium bicarbonate administration for urine alkalinization did not affect the concentration of mitomycin-C in non-muscle invasive bladder cancer patients.

    Science.gov (United States)

    Seo, Ho Kyung; Kim, Sung Han; Ahn, Kyung-Ohk; Lee, Sang-Jin; Park, Weon Seo; Kim, Sohee; Hwang, Sang-Hyun; Lee, Do Hoon; Joung, Jae Young; Chung, Jinsoo; Joo, Jungnam; Jeong, Kyung-Chae

    2017-11-10

    Sodium bicarbonate has been reported to maximize the efficacy of intravesical instillation of mitomycin-C (IVI-MMC) therapy by urine alkalinization in non-muscle-invasive bladder cancer (NMIBC). This study aimed to analyze the changes in MMC concentration according to urinary pH and evaluate the efficacy of sodium bicarbonate to maintain the concentration of active form of MMC during IVI-MMC. We prospectively enrolled 26 patients with NMIBC after transurethral resection of bladder tumor. Patients with very high-risk and low-risk NMIBC were excluded. Urinary creatinine, volume, pH, and concentrations of MMC and its degraded form were measured immediately before and after IVI-MMC. The patients were administered 1.5 g of oral sodium bicarbonate during the preceding evening, in the morning, and immediately before the fourth cycle of the six-cycle IVI-MMC. The correlation between MMC concentration and urinary pH changes was explored with or without oral bicarbonate therapy. Recurrence without progression to muscle-invasive disease was noted in 4 of 26 patients in a 23.7-month follow-up. The mean urinary pH before and after the therapy increased from 6.03 to 6.50, and 6.46 to 7.24, without or with oral SB therapy, respectively. Despite this increase, the concentration of active form of MMC did not change significantly. No correlation was found between urinary pH and MMC concentration. Urine alkalinization by SB administration did not maintain the high concentration of urinary MMC. Urine alkalinization by sodium bicarbonate administration for IVI-MMC did not maintain the high concentration of active urinary MMC in NMIBC.

  18. Monthly results of measurements, May 1989

    International Nuclear Information System (INIS)

    1989-01-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear plant sites and other sites. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accident [fr

  19. Monthly results of measurements, october 1987

    International Nuclear Information System (INIS)

    1987-10-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface waters, underground water, drinking water, sewage water, food chain (milk, vegetables, fishes), seawater around nuclear plant sites and other sites, sediments. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accident [fr

  20. Monthly results of measurements, October 1986

    International Nuclear Information System (INIS)

    1986-11-01

    This October 1986 report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear plant sites and other sites. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accident, with an exceptional control of migratory birds [fr

  1. Preliminary results from the hierarchical glitch pipeline

    International Nuclear Information System (INIS)

    Mukherjee, Soma

    2007-01-01

    This paper reports on the preliminary results obtained from the hierarchical glitch classification pipeline on LIGO data. The pipeline that has been under construction for the past year is now complete and end-to-end tested. It is ready to generate analysis results on a daily basis. The details of the pipeline, the classification algorithms employed and the results obtained with one days analysis on the gravitational wave and several auxiliary and environmental channels from all three LIGO detectors are discussed

  2. Monthly results of measurements, february 1987

    International Nuclear Information System (INIS)

    1987-03-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear plant sites and other sites. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobylsk accident [fr

  3. Monthly results of measurements, Nov 1988

    International Nuclear Information System (INIS)

    1988-01-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear plant sites and other sites. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accident [fr

  4. Monthly results of measurements, May 1987

    International Nuclear Information System (INIS)

    1987-06-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface waters, underground water, drinking water, sewage water, food chain (milk, vegetables, fishes), sea water around nuclear plant sites and other sites, sediments. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accident [fr

  5. Monthly results of measurements, November 1989

    International Nuclear Information System (INIS)

    1989-01-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear plant sites and other sites. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accident [fr

  6. Monthly results of measurements, August 1987

    International Nuclear Information System (INIS)

    1987-08-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface waters, underground water, drinking water, sewage water, food chain (milk, vegetables, fishes), sea water around nuclear plant sites and other sites, sediments. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accident [fr

  7. Salt Block II: description and results

    International Nuclear Information System (INIS)

    Hohlfelder, J.J.

    1980-06-01

    A description of and results from the Salt Block II experiment, which involved the heating of and measurement of water transport within a large sample of rock salt, are presented. These results include the measurement of water released into a heated borehole in the sample as well as measured temperatures within the salt. Measured temperatures are compared with the results of a mathematical model of the experiment

  8. Monthly results of measurements, January 1987

    International Nuclear Information System (INIS)

    1987-01-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, cattle thyroids, fishes), sea water around nuclear plant sites and other sites, sediments. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accident, in various food samples [fr

  9. Monthly results of measurements, August 1986

    International Nuclear Information System (INIS)

    1986-08-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes) seawater around nuclear plant sites and other sites. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accident [fr

  10. Monthly results of measurements, July 1986

    International Nuclear Information System (INIS)

    1986-08-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear plant sites and other sites. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accidents [fr

  11. Monthly results of measurements, Oct 1989

    International Nuclear Information System (INIS)

    1989-01-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear plant sites and other sites. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accident [fr

  12. Monthly results of measurements, Aug 1989

    International Nuclear Information System (INIS)

    1989-01-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear plant sites and other sites. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accident [fr

  13. Monthly results of measurements, Oct 1988

    International Nuclear Information System (INIS)

    1988-01-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear plant sites and other sites. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accident [fr

  14. Setting Priorities Personal Values, Organizational Results

    CERN Document Server

    (CCL), Center for Creative Leadership

    2011-01-01

    To be a successful leader, you need to get results. To get results, you need to set priorities. This book can help you do a better job of setting priorities, recognizing the personal values that motivate your decision making, the probable trade-offs and consequences of your decisions, and the importance of aligning your priorities with your organization's expectations. In this way you can successfully meet organizational objectives and consistently produce results.

  15. Monthly results of measurements, november 1986

    International Nuclear Information System (INIS)

    1986-12-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear plant sites and other sites. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accident [fr

  16. Monthly results of measurements, Jul 1989

    International Nuclear Information System (INIS)

    1989-01-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear plant sites and other sites. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accident [fr

  17. Monthly results of measurements April 1987

    International Nuclear Information System (INIS)

    1987-05-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear plant sites and other sites. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accident [fr

  18. Monthly results of measurements, Apr 1988

    International Nuclear Information System (INIS)

    1988-04-01

    This report of the SCPRI exposes an interpretation of the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear plant sites and other sites. The activities of various radioisotopes are presented in tables. This report exposes also the results of special radiation measurements resulting from the Chernobyl accident [fr

  19. Search Results | Page 45 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2007-01-01

    Results 441 - 450 of 8491 ... Issues : global change - climate change and variability / risk - vulnerability / research - capacity building - governance / science - communication - decision processes. Published date. January 1, 2007. Studies.

  20. Search Results | Page 65 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 641 - 650 of 1119 ... Reports. AGRICULTURAL RESEARCH INFORMATION MANAGEMENT KNOWLEDGE ... Knowledge and ideas: IDRC's third Annual Public Meeting ... Agricultural technologies bring healthy diversity to school meals.

  1. Search Results | Page 50 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 491 - 500 of 9601 ... ... WOMEN'S RIGHTS (162) Apply WOMEN'S RIGHTS filter · GENDER ... Knowledge for Democracy Myanmar (7) Apply Knowledge for ... INDIGENOUS POPULATION ETHNIC MINORITIES TRADITIONAL CULTURE ...

  2. Search Results | Page 826 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 8251 - 8260 of 8494 ... Open data leaders in government finally have a support network - each other ... CRIME PREVENTION SOUTH AFRICA MASCULINITY ... ORGANIZATIONAL CHANGE LEADERSHIP PARTICIPATORY RESEARCH ...

  3. Search Results | Page 816 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 8151 - 8160 of 8492 ... HEALTH FINANCING HEALTH ECONOMICS HEALTH EQUITY TAX ... TAX REVENUES CORPORATE SOCIAL RESPONSIBILITY ... PRINCIPLE TOBACCO CONTROL RESOURCE ALLOCATION TAX REVENUES ...

  4. Search Results | Page 21 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2011-01-01

    Results 201 - 210 of 1368 ... Public innovation financing schemes in Singapore. Published date. Saturday, January 1, 2011 - 00:00. Papers. PHARMACEUTICALS CORPORATE SOCIAL RESPONSIBILITY INTELLECTUAL PROPERTY ...

  5. Search Results | Page 15 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2008-01-01

    Results 141 - 150 of 1310 ... Smoking, poverty and ill-health in China. Published date. January 1, 2008. Papers. TELECOMMUNICATIONS EDUCATION ECONOMIC DEVELOPMENT HEALTH ECONOMICS ENVIRONMENTAL EDUCATION GOVERNMENT ...

  6. Search Results | Page 795 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 7941 - 7950 of 8491 ... Development research in countries in transition: Introduction. Research in Action. Health Ecohealth CONTAMINATION Pollution MERCURY POISONING, NERVOUS SYSTEM MERCURY Gender ...

  7. Search Results | Page 41 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 401 - 410 of 8491 ... Development GENDER EQUALITY WOMEN'S ECONOMIC EMPOWERMENT WOMEN'S RIGHTS FEMINISM ... Health, SDGs, and public policy—the role of policy research institutions ... TECHNICAL EDUCATION ...

  8. EDF - Electricite de France, 2017 annual Results

    International Nuclear Information System (INIS)

    2018-01-01

    The EDF Group is an integrated energy supplier operating in a wide range of electricity-related businesses: generation, transmission, distribution, sale and trading of energy. It is the main operator in the French electricity market and one of the leading electricity groups in Europe. The EDF Group has built a business model balanced between deregulated and regulated operations in France and an international presence. This document is EDF Group's annual Results for 2017. It is made of several reports: The annual Results press release, The annual Results presentation and its appendices, The financial report, The Consolidated Financial Statements at 31 December 2017, The Statutory Auditors' report, The transcript of the Investors and Analysts conference, The 3rd quarter 2017 results press release, the 3rd quarter 2017 results presentation and its appendices, The transcript of the Investors and Analysts conference, The first quarter 2017 results press release, The first quarter 2017 results presentation with its appendices, The transcript of the Investors and Analysts conference, The 2017 half-year results press release, The 2017 half-year results presentation with its appendices, The 2017 half-year financial report, The Consolidated Financial Statements at 30 June 2017, The 2017 half-year Statutory Auditors' report, The transcript of the Investors and Analysts conference

  9. Search Results | Page 818 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 8171 - 8180 of 8492 ... WOMEN'S RIGHTS POLITICAL BEHAVIOUR POLITICAL ... Should a seemingly sudden change of political attitude, which has led ... ADAPTIVE CAPACITY PAKISTAN ENVIRONMENTAL EMERGENCIES FLOODS ...

  10. Search Results | Page 73 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 721 - 730 of 870 ... Electronic Government : Caribbean Pilot Project. Caribbean countries are increasingly adopting information and communication technologies (ICTs) in the process of modernizing their public sectors.

  11. Search Results | Page 34 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 331 - 340 of 374 ... Electronic Government : Caribbean Pilot Project. Caribbean countries are increasingly adopting information and communication technologies (ICTs) in the process of modernizing their public sectors.

  12. Search Results | Page 24 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 231 - 240 of 8492 ... AGRICULTURAL DEVELOPMENT WOMEN IN AGRICULTURE Gender ... policymakers, agricultural businesses, researchers, and agriculture donors. ... GENDER EQUALITY FAMILY FARMS WOMEN'S ECONOMIC ...

  13. Search Results | Page 78 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2009-01-01

    Results 771 - 780 of 8491 ... Adaptation to climate change in Calakmul, Campeche, Mexico : bridging disciplines and scales with scenario based integrative modeling. Published date. January 1, 2009. Studies.

  14. Search Results | Page 85 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2009-01-01

    Results 841 - 850 of 8531 ... Adaptation to climate change in Calakmul, Campeche, Mexico : bridging disciplines and scales with scenario based integrative modeling. Published date. January 1, 2009. Studies.

  15. Search Results | Page 7 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 61 - 70 of 9602 ... ... INFORMATION TECHNOLOGY 514 Apply INFORMATION TECHNOLOGY filter .... TRAINING INDIGENOUS POPULATION MEDICAL PERSONNEL ... RURAL AREAS BOTSWANA INCOME GENERATION TOURISM ...

  16. Search Results | Page 801 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 8001 - 8010 of 8519 ... Modeling the determinants of job satisfaction in Vietnam ... building HUMAN RESOURCES DEVELOPMENT LABOUR PRODUCTIVITY ... RICE AGRICULTURAL EXTENSION RISK MANAGEMENT CROP LOSSES ...

  17. New results on flavor production at PEP

    International Nuclear Information System (INIS)

    Barbaro-Galtieri, A.

    1984-05-01

    This report includes results from five PEP detectors: DELCO, HRS, MAC, MARK II and TPC. All, except the TPC, are presently taking data at PEP. The TPC is being upgraded: a new superconducting coil is being installed and other improvements are being implemented. The results discussed here are either new or improved since the Cornell Conference. New results on Particle Searches and a limit on neutrino generations are discussed. New data are included on weak couplings of c and b quarks. Various new results on hadron production are reported. All data were obtained in e +- collisions with total energy √s=29 GeV. 54 references

  18. Search Results | Page 91 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 901 - 910 of 1119 ... AGRICULTURE Food security COWPEAS BURKINA FASO ... SOIL POLLUTION IRRIGATION DEVELOPMENT MIDDLE EAST Food security AGRICULTURE. Sustainable management of wastewater for agriculture ...

  19. Search Results | Page 60 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 591 - 600 of 1119 ... Journal articles. Food security RAINFED FARMING BURKINA FASO CLIMATE CHANGE ADAPTATION RUNOFF WATER SAHEL ... PROTECTION Environmental economics ENVIRONMENTAL MANAGEMENT ...

  20. Search Results | Page 94 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 931 - 940 of 1119 ... Journal articles. POTATOES Food security CHROMATOGRAPHY NUTRITION ... management practices, environmental degradation, and agricultural modernization programs that benefit the elite but disadvantage.