WorldWideScience

Sample records for nonmetropolitan growth nodes

  1. Factors Associated with the Development of Nonmetropolitan Growth Nodes in Producer Services Industries, 1980-1990

    Science.gov (United States)

    Goe, W. Richard

    2002-01-01

    Over the 1980-1990 period, employment in producer services industries in the nonmetropolitan United States increased substantially. This growth resulted in the development of "nonmetropolitan growth nodes" in producer services industries. A growth node refers to a nonmetropolitan area that contains a greater than average concentration of…

  2. Education and Nonmetropolitan Income Growth in the South.

    Science.gov (United States)

    Henry, Mark; Barkley, David; Li, Haizhen

    Investigations of the linkages between improved schools and local economic development are rare. This paper considers several models that introduce human capital as a potential source of economic growth in the rural South. Results from various econometric models indicate that across the South, county per capita income growth rates from 1970 to…

  3. Growth and Change in Nonmetropolitan Schools: Effects of the Population Migration Turnaround in Osceola County, Michigan During the 1970's.

    Science.gov (United States)

    Frankena, Frederick

    Findings of a study to establish the determinants and effects of urban to rural population migration patterns in Osceola County, Michigan, where a 27.6% increase (4,090 people) occurred during the 1970's, illustrate typical effects of population migration turnaround on nonmetropolitan schools. The study revealed that school facilities were…

  4. Nonmetropolitan Migration: The Influence of Neglected Variables.

    Science.gov (United States)

    Cook, Annabel Kirschner

    1987-01-01

    Compares influence of employment growth/diversity, commuting, retirement migration, income, unemployment, age structure, and adjacency with influence of nonfarm self-employment and percentage of labor force that is female on recent declines in nonmetropolitan growth rates. Suggests last two variables are more important determinants of…

  5. Recent nonmetropolitan population change in fifty-year perspective.

    Science.gov (United States)

    Johnson, K M; Purdy, R L

    1980-02-01

    Post-1970 nonmetropolitan population shifts are examined by dividing nonmetropolitan counties into ten cohorts based on the duration and direction of consistent population change since 1920. Analysis indicates that the post-1970 gains reported by Beale are pervasive in nonmetropolitan America, occurring even in a majority of the counties that lost population consistently from 1920 to 1970. Growth was greatest in countries adjacent to metropolitan areas but was more than urban spillover effect. In a clear break with traditional patterns, net inmigration contributed significantly to overall population gain and was particularly strong among countries without an urban center. The rate of natural increase continued to slow in the post-1970 period, with natural decrease becoming common among countries with protracted histories of population decline.

  6. Newspaper Advertising Impact in Non-Metropolitan Markets.

    Science.gov (United States)

    Lynn, Jerry R.

    A telephone survey of 1,487 adults in 91 nonmetropolitan areas of Tennessee was conducted to determine the nonmetropolitan newspaper audience, the exposure and effectiveness of nonmetro newspaper advertising, and the complementary relationship of advertising media, particularly newspapers and television, in nonmetropolitan markets. The results…

  7. Newspaper Advertising Impact in Non-Metropolitan Markets.

    Science.gov (United States)

    Lynn, Jerry R.

    A telephone survey of 1,487 adults in 91 nonmetropolitan areas of Tennessee was conducted to determine the nonmetropolitan newspaper audience, the exposure and effectiveness of nonmetro newspaper advertising, and the complementary relationship of advertising media, particularly newspapers and television, in nonmetropolitan markets. The results…

  8. Underlying causes of the emerging nonmetropolitan mortality penalty.

    Science.gov (United States)

    Cossman, Jeralynn S; James, Wesley L; Cosby, Arthur G; Cossman, Ronald E

    2010-08-01

    The nonmetropolitan mortality penalty results in an estimated 40 201 excessive US deaths per year, deaths that would not occur if nonmetropolitan and metropolitan residents died at the same rate. We explored the underlying causes of the nonmetropolitan mortality penalty by examining variation in cause of death. Declines in heart disease and cancer death rates in metropolitan areas drive the nonmetropolitan mortality penalty. Future work should explore why the top causes of death are higher in nonmetropolitan areas than they are in metropolitan areas.

  9. Gibberellins and DELLAs: central nodes in growth regulatory networks.

    Science.gov (United States)

    Claeys, Hannes; De Bodt, Stefanie; Inzé, Dirk

    2014-04-01

    Gibberellins (GAs) are growth-promoting phytohormones that were crucial in breeding improved semi-dwarf varieties during the green revolution. However, the molecular basis for GA-induced growth stimulation is poorly understood. In this review, we use light-regulated hypocotyl elongation as a case study, combined with a meta-analysis of available transcriptome data, to discuss the role of GAs as central nodes in networks connecting environmental inputs to growth. These networks are highly tissue-specific, with dynamic and rapid regulation that mostly occurs at the protein level, directly affecting the activity and transcription of effectors. New systems biology approaches addressing the role of GAs in growth should take these properties into account, combining tissue-specific interactomics, transcriptomics and modeling, to provide essential knowledge to fuel a second green revolution.

  10. Ecological Correlates of Inmigration to Nonmetropolitan Areas.

    Science.gov (United States)

    Eisenberg, Michael

    The following four hypotheses were tested: (1) nonmetropolitan areas with the highest percentages employed in industry in 1960 will experience the greatest inmigration between 1965-70; (2) those with a high percentage employed in agriculture will experience the lowest amounts of inmigration; (3) those areas with small farm size and low farm income…

  11. Fractional Dynamics of Network Growth Constrained by Aging Node Interactions.

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    Hadiseh Safdari

    Full Text Available In many social complex systems, in which agents are linked by non-linear interactions, the history of events strongly influences the whole network dynamics. However, a class of "commonly accepted beliefs" seems rarely studied. In this paper, we examine how the growth process of a (social network is influenced by past circumstances. In order to tackle this cause, we simply modify the well known preferential attachment mechanism by imposing a time dependent kernel function in the network evolution equation. This approach leads to a fractional order Barabási-Albert (BA differential equation, generalizing the BA model. Our results show that, with passing time, an aging process is observed for the network dynamics. The aging process leads to a decay for the node degree values, thereby creating an opposing process to the preferential attachment mechanism. On one hand, based on the preferential attachment mechanism, nodes with a high degree are more likely to absorb links; but, on the other hand, a node's age has a reduced chance for new connections. This competitive scenario allows an increased chance for younger members to become a hub. Simulations of such a network growth with aging constraint confirm the results found from solving the fractional BA equation. We also report, as an exemplary application, an investigation of the collaboration network between Hollywood movie actors. It is undubiously shown that a decay in the dynamics of their collaboration rate is found, even including a sex difference. Such findings suggest a widely universal application of the so generalized BA model.

  12. Fractional Dynamics of Network Growth Constrained by Aging Node Interactions

    Science.gov (United States)

    Safdari, Hadiseh; Zare Kamali, Milad; Shirazi, Amirhossein; Khalighi, Moein; Jafari, Gholamreza; Ausloos, Marcel

    2016-01-01

    In many social complex systems, in which agents are linked by non-linear interactions, the history of events strongly influences the whole network dynamics. However, a class of “commonly accepted beliefs” seems rarely studied. In this paper, we examine how the growth process of a (social) network is influenced by past circumstances. In order to tackle this cause, we simply modify the well known preferential attachment mechanism by imposing a time dependent kernel function in the network evolution equation. This approach leads to a fractional order Barabási-Albert (BA) differential equation, generalizing the BA model. Our results show that, with passing time, an aging process is observed for the network dynamics. The aging process leads to a decay for the node degree values, thereby creating an opposing process to the preferential attachment mechanism. On one hand, based on the preferential attachment mechanism, nodes with a high degree are more likely to absorb links; but, on the other hand, a node’s age has a reduced chance for new connections. This competitive scenario allows an increased chance for younger members to become a hub. Simulations of such a network growth with aging constraint confirm the results found from solving the fractional BA equation. We also report, as an exemplary application, an investigation of the collaboration network between Hollywood movie actors. It is undubiously shown that a decay in the dynamics of their collaboration rate is found, even including a sex difference. Such findings suggest a widely universal application of the so generalized BA model. PMID:27171424

  13. Lymph node transfer and perinodal lymphatic growth factor treatment for lymphedema.

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    Honkonen, Krista M; Visuri, Mikko T; Tervala, Tomi V; Halonen, Paavo J; Koivisto, Mari; Lähteenvuo, Markku T; Alitalo, Kari K; Ylä-Herttuala, Seppo; Saaristo, Anne M

    2013-05-01

    Our objective was to define the optimal growth factor treatment to be used in combination with lymph node transfer to normalize lymphatic vascular anatomy. In the lymph node transfer method, lymphatic anastomoses are expected to form spontaneously. However, lymphangiogenic growth factor therapies have shown promising results in preclinical models of lymphedema. The inguinal lymphatic vasculature of pigs was surgically destroyed around the inguinal lymph node. To enhance the regrowth of the lymphatic network in the defected area, adenoviral vascular endothelial growth factor C (VEGF-C) was administered intranodally or perinodally. Control animals received injections of saline or control vector. The lymphangiogenic effect of the growth factor therapy and any potential adverse effects associated with the 2 alternative delivery routes were examined 2 months postoperatively. Both routes of growth factor administration induced robust growth of lymphatic vessels and helped to preserve the structure of the transferred lymph nodes in comparison with the controls. The lymph nodes of the control treated animals regressed in size and their nodal structure was partly replaced by fibro-fatty scar tissue. Intranodally injected adenoviral VEGF-C and adenoviral vector encoding control gene LacZ induced macrophage accumulation inside the node, whereas perinodal administration of VEGF-C did not have this adverse effect. Lymphangiogenic growth factors improve lymphatic vessel regeneration and lymph node function after lymph node transfer. The perinodal route of delivery provides a basis for future clinical trials in lymphedema patients.

  14. Lymphatic Vessel Function and Lymphatic Growth Factor Secretion after Microvascular Lymph Node Transfer in Lymphedema Patients

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    Tiina P. Viitanen, MD

    2013-05-01

    Conclusions: Reconstructing the lymphatic anatomy of the axilla with a lymph node flap may offer possibilities that other reconstructive options are lacking. However, we will need further reports and comparative studies about the clinical efficacy of this new promising technique. In addition to the transferred lymph nodes, lymphatic growth factor production may also be induced by other factors related to microvascular breast reconstruction.

  15. The Renewal of Population Loss in the Nonmetropolitan Great Plains.

    Science.gov (United States)

    Albrecht, Don E.

    1993-01-01

    Analysis of population trends in 293 nonmetropolitan counties in the Great Plains, 1950-90, reveals that the rural population turnaround of the 1970s has indeed ended. During the 1980s, 84% of these counties had total population declines, and 96% had net outmigration. The most important variable in producing positive trends was inmigration of…

  16. Influence of homology and node age on the growth of protein-protein interaction networks.

    Science.gov (United States)

    Bottinelli, Arianna; Bassetti, Bruno; Lagomarsino, Marco Cosentino; Gherardi, Marco

    2012-10-01

    Proteins participating in a protein-protein interaction network can be grouped into homology classes following their common ancestry. Proteins added to the network correspond to genes added to the classes, so the dynamics of the two objects are intrinsically linked. Here we first introduce a statistical model describing the joint growth of the network and the partitioning of nodes into classes, which is studied through a combined mean-field and simulation approach. We then employ this unified framework to address the specific issue of the age dependence of protein interactions through the definition of three different node wiring or divergence schemes. A comparison with empirical data indicates that an age-dependent divergence move is necessary in order to reproduce the basic topological observables together with the age correlation between interacting nodes visible in empirical data. We also discuss the possibility of nontrivial joint partition and topology observables.

  17. Universal approximation of extreme learning machine with adaptive growth of hidden nodes.

    Science.gov (United States)

    Zhang, Rui; Lan, Yuan; Huang, Guang-Bin; Xu, Zong-Ben

    2012-02-01

    Extreme learning machines (ELMs) have been proposed for generalized single-hidden-layer feedforward networks which need not be neuron-like and perform well in both regression and classification applications. In this brief, we propose an ELM with adaptive growth of hidden nodes (AG-ELM), which provides a new approach for the automated design of networks. Different from other incremental ELMs (I-ELMs) whose existing hidden nodes are frozen when the new hidden nodes are added one by one, in AG-ELM the number of hidden nodes is determined in an adaptive way in the sense that the existing networks may be replaced by newly generated networks which have fewer hidden nodes and better generalization performance. We then prove that such an AG-ELM using Lebesgue p-integrable hidden activation functions can approximate any Lebesgue p-integrable function on a compact input set. Simulation results demonstrate and verify that this new approach can achieve a more compact network architecture than the I-ELM.

  18. What's Different Away from the Rat Race?: Issues for VET in Non-Metropolitan Australia. CRLRA Discussion Paper Series.

    Science.gov (United States)

    Kilpatrick, Sue; Bell, Rowena

    A review of research literature relating to vocational education and training (VET) in non-metropolitan Australia identified issues which differentially impact metropolitan and non-metropolitan Australia and research needs. Findings indicated non-metropolitan Australia is diverse in terms of population density, educational experiences of the…

  19. Net Migration Turnaround in Pennsylvania Nonmetropolitan Minor Civil Divisions, 1960-70

    Science.gov (United States)

    Humphrey, Craig R.; And Others

    1977-01-01

    The research examines the structural and spatial features of Pennsylvania nonmetropolitan places with net outmigration, 1940-60, and net inmigration, 1960-70, in comparison with Pennsylvania nonmetropolitan places with net outmigration, 1940-70. A one-way analysis of variance and step-wise discriminant function analysis were used. (Author/NQ)

  20. Leading Causes of Death in Nonmetropolitan and Metropolitan Areas- United States, 1999-2014.

    Science.gov (United States)

    Moy, Ernest; Garcia, Macarena C; Bastian, Brigham; Rossen, Lauren M; Ingram, Deborah D; Faul, Mark; Massetti, Greta M; Thomas, Cheryll C; Hong, Yuling; Yoon, Paula W; Iademarco, Michael F

    2017-01-13

    Higher rates of death in nonmetropolitan areas (often referred to as rural areas) compared with metropolitan areas have been described but not systematically assessed. 1999-2014 DESCRIPTION OF SYSTEM: Mortality data for U.S. residents from the National Vital Statistics System were used to calculate age-adjusted death rates and potentially excess deaths for nonmetropolitan and metropolitan areas for the five leading causes of death. Age-adjusted death rates included all ages and were adjusted to the 2000 U.S. standard population by the direct method. Potentially excess deaths are defined as deaths among persons aged leading causes were higher in nonmetropolitan areas than in metropolitan areas. For example, approximately half of deaths from unintentional injury and chronic lower respiratory disease in nonmetropolitan areas were potentially excess deaths, compared with 39.2% and 30.9%, respectively, in metropolitan areas. Potentially excess deaths also differed among and within public health regions; within regions, nonmetropolitan areas tended to have higher percentages of potentially excess deaths than metropolitan areas. Compared with metropolitan areas, nonmetropolitan areas have higher age-adjusted death rates and greater percentages of potentially excess deaths from the five leading causes of death, nationally and across public health regions. Routine tracking of potentially excess deaths in nonmetropolitan areas might help public health departments identify emerging health problems, monitor known problems, and focus interventions to reduce preventable deaths in these areas.

  1. The Revival of Population Growth in Nonmetropolitan America.

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    Beale, Calvin L.

    Population grew faster in nonmetro than in metro countries of the United States between 1970 and 1973. This trend reverses the previous pattern of inmigration to cities. Among the reasons for increases in rural areas and small towns are: (1) decentralization of manufacturing and other industry; (2) increased settlement of retired people; (3)…

  2. Southern (DisComfort?: Latino Population Growth, Economic Integration and Spatial Assimilation in North Carolina Micropolitan Areas

    Directory of Open Access Journals (Sweden)

    Ana-María González Wahl

    2007-10-01

    Full Text Available This paper examines more closely the growth and assimilation of the Latino population in non-metropolitan areas across North Carolina. More specifically, the analysis focuses on micropolitan areas. Based on the last decennial census, micropolitan areas were newly defined by the Census Bureau to reflect the growing importance of "urban clusters" located in non-metropolitan counties.

  3. Direct regeneration of Periwinkle (Catharanthus roseus via node explants culture and different combinations of plant growth regulators

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    M. Talebi

    2012-09-01

    Full Text Available Periwinkle (Catharanthus roseus L., Apocynaceae contains more than 130 different terpenoid indole alkaloids (TIAs, of which two dimeric alkaloids, Vinblastine and Vincristine, have antineoplastic activity and are useful in treatment of various cancers. Specific production of some alkaloids in differentiated tissues such as leaf and stem led to use direct regeneration of explants in order to increase the production of these important alkaloids in the plant. In this research, 30 combinations of plant growth regulators and activated charcoal were used in MS media for direct regeneration of node explants. Application of BAP in media containing 1 g/l activated charcoal showed the best direct regeneration of node explants and shoot proliferation. Although application of activated charcoal is necessary for periwinkle growth in media due to many phenolic compounds, but it has negative effects on adsorption of plant growth regulators and consequently reduce shoot proliferation. Therefore, it seems that 1 g/l activated charcoal is an appropriate concentration for preparing shoot proliferation media. In addition, transporting regenerated shoots to culture media containing NAA resulted in increasing shoot length. Proliferated shoots rooted in media without PGR and with 2 g/l activated charcoal and acclimated with environmental conditions after transferring to the soil.

  4. Loss of CDH1 (E-cadherin) expression is associated with infiltrative tumour growth and lymph node metastasis.

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    Kim, Sun A; Inamura, Kentaro; Yamauchi, Mai; Nishihara, Reiko; Mima, Kosuke; Sukawa, Yasutaka; Li, Tingting; Yasunari, Mika; Morikawa, Teppei; Fitzgerald, Kathryn C; Fuchs, Charles S; Wu, Kana; Chan, Andrew T; Zhang, Xuehong; Ogino, Shuji; Qian, Zhi Rong

    2016-01-19

    Loss of CDH1 (E-cadherin) expression in cancer cells may promote cell migration and invasion. Therefore, we hypothesised that loss of CDH1 expression in colorectal carcinoma might be associated with aggressive features and clinical outcome. Utilising molecular pathological epidemiology database of 689 rectal and colon cancer cases in the Nurses' Health Study and the Health Professionals Follow-up Study, we assessed tumour CDH1 expression by immunohistochemistry. Multivariate logistic regression analysis was conducted to assess association of CDH1 loss with tumour growth pattern (expansile-intermediate vs infiltrative) and lymph node metastasis and distant metastasis, controlling for potential confounders including microsatellite instability, CpG island methylator phenotype, LINE-1 methylation, and PIK3CA, BRAF and KRAS mutations. Mortality according to CDH1 status was assessed using Cox proportional hazards model. Loss of tumour CDH1 expression was observed in 356 cases (52%), and associated with infiltrative tumour growth pattern (odds ratio (OR), 2.02; 95% confidence interval (CI), 1.23-3.34; P=0.006) and higher pN stage (OR, 1.73; 95% CI, 1.23-2.43; P=0.001). Tumour CDH1 expression was not significantly associated with distant metastasis or prognosis. Loss of CDH1 expression in colorectal cancer is associated with infiltrative tumour growth pattern and lymph node metastasis.

  5. Pharmacy Characteristics Associated with the Provision of Drug Therapy Services in Nonmetropolitan Community Pharmacies

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    Gadkari, Abhijit S.; Mott, David A.; Kreling, David H.; Bonnarens, Joseph K.

    2009-01-01

    Context: Higher prevalence of chronic diseases and reduced access to other health professionals in rural areas suggest that rural Medicare enrollees will benefit from pharmacist-provided drug therapy services (DTS). Purpose: The purpose of this study was to describe non-metropolitan community pharmacy sites in Wisconsin, the provision of DTS at…

  6. Value of Vocational Education and Training in a Non-Metropolitan Community. CRLRA Discussion Paper Series.

    Science.gov (United States)

    Toms, Jon; Golding, Barry; Falk, Ian; Kilpatrick, Sue

    A study examined the question of how one Australian non-metropolitan community consolidates and develops sustainable economic and social activity through the learning of community members. The research used a focused interview process with open-ended questions with these 2 major sub-groups in the community and explored their interrelatedness: 2…

  7. Migration to Nonmetropolitan Areas: Appraising the Trend and Reasons for Moving. Special Demographic Analyses.

    Science.gov (United States)

    Long, Larry H.; DeAre, Diana

    An unexpected demographic development in the United States in the 1970's was the shift of nonmetropolitan areas to net inmigration, reversing a 70-year trend. Using the 1970 definition of metropolitan, the percent of the population living in metropolitan areas fell from 69% in 1970 to 67.8% in 1978. No easily identifiable set of reasons explained…

  8. Issues in the Economic Development of Nonmetropolitan United States. Economic Development Research Report.

    Science.gov (United States)

    Ledebur, Larry C.

    Describing issues relative to economic development in nonmetropolitan areas, this document presents narrative and tabular data re: (1) the causal forces behind economic decline in rural America (technology, shifting patterns of demand for goods and services, and changes in life styles and residential preferences); (2) the incidence and indicators…

  9. Aspirations of Chicano Youth from the Texas Border Region: A Metropolitan-Nonmetropolitan Comparison.

    Science.gov (United States)

    Kuvlesky, William P.; Venegas, Moises

    The document tested the level of generalization of a recent conclusion from past research (see ED075156) on nonmetropolitan (NM) south and southwest Texas Mexican American teenagers: that these youths have predominantly high and strong status aspirations and expectations. Earlier findings on NM Mexican American youth supported Merton's thesis that…

  10. Do Metropolitan and Nonmetropolitan Chicano Youth Differ: A Study of South Texas Teen-Agers - 1973.

    Science.gov (United States)

    Venegas, Moises; Kuvlesky, William

    Based on comparative data from two 1973 studies, this study examined whether or not the occupational and educational status projections and language usage patterns of Mexican American teenagers living in a large metropolitan area differed from those of teenagers living in isolated, relatively small nonmetropolitan places. The two separate, but…

  11. The Longitudinal Effect of Drug Use on Productivity Status of Nonmetropolitan African American Young Adults

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    Roldós, María Isabel

    2014-01-01

    The purpose of this study was to investigate the longitudinal effect of marijuana and heavy alcohol use on the productivity status of nonmetropolitan African American young adults. This analysis was based on secondary data from the Family and Community Health Study. For alcohol, the study evaluated the effects on productivity status for…

  12. Natural Environments, Obesity, and Physical Activity in Nonmetropolitan Areas of the United States

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    Michimi, Akihiko; Wimberly, Michael C.

    2012-01-01

    Purpose: To assess the associations of the natural environment with obesity and physical activity in nonmetropolitan areas of the United States among representative samples by using 2 indices of outdoor activity potential (OAP) at the county level. Methods: We used the data from 457,820 and 473,296 noninstitutionalized adults aged over 18 years…

  13. Pharmacy Characteristics Associated with the Provision of Drug Therapy Services in Nonmetropolitan Community Pharmacies

    Science.gov (United States)

    Gadkari, Abhijit S.; Mott, David A.; Kreling, David H.; Bonnarens, Joseph K.

    2009-01-01

    Context: Higher prevalence of chronic diseases and reduced access to other health professionals in rural areas suggest that rural Medicare enrollees will benefit from pharmacist-provided drug therapy services (DTS). Purpose: The purpose of this study was to describe non-metropolitan community pharmacy sites in Wisconsin, the provision of DTS at…

  14. Vascular endothelial growth factor C (VEGF-C in esophageal cancer correlates with lymph node metastasis and poor patient prognosis

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    Naganawa Yasuhiro

    2010-06-01

    Full Text Available Abstract Background The diagnosis of lymph node metastasis in esophageal cancer by the presence and number of metastatic lymph nodes is an extremely important prognostic factor. In addition, the indication of non-surgical therapy is gaining more attention. Vascular endothelial growth factor C (VEGF-C is potentially lymphangiogenic and selectively induces hyperplasia of the lymphatic vasculature. In this study, we investigated the expression of VEGF-C and whether it correlated with various clinico-pathologic findings. Methods KYSE series of esophageal cancer cell lines and 106 patients with primary esophageal squamous cell carcinomas who had undergone radical esophagectomy were analyzed. VEGF-C mRNA expression was determined by quantitative RT-PCR. Results High expression of VEGF-C was detected in most of the KYSE cell lines, especially KYSE410, yet, in an esophageal normal epithelium cell line, Het-1A, VEGF-C was not detected. In the clinical specimen, the expression of VEGF-C in the cancerous tissue was higher than in the corresponding noncancerous esophageal mucosa (p = 0.026. The expression of VEGF-C was found to be higher in Stage2B-4A tumors than in Stage0-2A tumors (p = 0.049. When the patients were divided into two groups according to their expression levels of VEGF-C (a group of 53 cases with high expression and a group of 53 cases with low expression, the patients with high VEGF-C expression had significantly shorter survival after surgery than the patients with low expression (p = 0.0065. Although univariate analysis showed that high expression of VEGF-C was a statistically significant prognostic factor, this was not shown in multivariate analysis. In the subgroup of patients with Tis and T1 tumors, the expression of VEGF-C was higher in N1 tumors than in N0 tumors (p = 0.029. The survival rate of patients from the high expression group (n = 10 was lower than that in the low expression group (n = 11, and all the patients in the low

  15. Alendronate decreases orthotopic PC-3 prostate tumor growth and metastasis to prostate-draining lymph nodes in nude mice

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    Väänänen Kalervo

    2008-03-01

    Full Text Available Abstract Background Metastatic prostate cancer is associated with a high morbidity and mortality but the spreading mechanisms are still poorly understood. The aminobisphosphonate alendronate, used to reduce bone loss, has also been shown to inhibit the invasion and migration of prostate cancer cells in vitro. We used a modified orthotopic PC-3 nude mouse tumor model of human prostate cancer to study whether alendronate affects prostate tumor growth and metastasis. Methods PC-3 cells (5 × 105 were implanted in the prostates of nude mice and the mice were treated with alendronate (0.5 mg/kg/day in PBS, s.c. or vehicle for 4 weeks. After sacrifice, the sizes of tumor-bearing prostates were measured and the tumors and prostate-draining regional iliac and sacral lymph nodes were excised for studies on markers of proliferation, apoptosis, angiogenesis and lymphangiogenesis, using histomorphometry and immunohistochemistry. Results Tumor occurrence in the prostate was 73% in the alendronate-treated group and 81% in the control group. Mean tumor size (218 mm3, range: 96–485 mm3, n = 11 in the alendronate-treated mice was 41% of that in the control mice (513 mm3, range: 209–1350 mm3, n = 13 (p p p p Conclusion Our results demonstrate that alendronate treatment opposes growth of orthotopic PC-3 tumors and decreases tumor metastasis to prostate-draining lymph nodes. This effect could be at least partly explained by decreased angiogenesis and increased apoptosis. The results suggest that bisphosphonates have anti-tumoral and anti-invasive effects on primary prostate cancer.

  16. Factors associated with involvement in nonmetropolitan LGBTQ organizations: Proximity? Generativity? Minority stress? Social location?

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    Paceley, Megan S; Oswald, Ramona Faith; Hardesty, Jennifer L

    2014-01-01

    Little is known about involvement in LGBTQ organizations. Factors associated with involvement in nonmetropolitan LGBTQ organizations were examined using logistic regression and survey data from 426 LGBTQ individuals residing in a nonmetropolitan region. Involvement was examined in five types of organizations (professional, social/recreational, religious, political, and community center/charity). The same model testing proximity, generativity, minority stress, and social location hypotheses was repeated for each organization type. Results demonstrate that the generativity hypothesis is most strongly supported. Indeed, emotional attachment to the LGBTQ community significantly increased the odds of involvement in every type of organization. However, the factors associated with involvement otherwise differed by organization type. Implications for organizational leaders are discussed.

  17. Raloxifene inhibits tumor growth and lymph node metastasis in a xenograft model of metastatic mammary cancer

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    Li Zhong-Lian

    2010-10-01

    Full Text Available Abstract Background The effects of raloxifene, a novel selective estrogen receptor modulator, were studied in a mouse metastatic mammary cancer model expressing cytoplasmic ERα. Methods Mammary tumors, induced by inoculation of syngeneic BALB/c mice with BJMC3879luc2 cells, were subsequently treated with raloxifene at 0, 18 and 27 mg/kg/day using mini-osmotic pumps. Results In vitro study demonstrated that the ERα in BJMC3879luc2 cells was smaller (between 50 and 64 kDa than the normal-sized ERα (66 kDa and showed cytoplasmic localization. A statistically significant but weak estradiol response was observed in this cell line. When BJMC3879luc2 tumors were implanted into mice, the ERα mRNA levels were significantly higher in females than in males. In vitro studies showed that raloxifene induced mitochondria-mediated apoptosis and cell-cycle arrest in the G1-phase and a decrease in the cell population in the S-phase. In animal experiments, tumor volumes were significantly suppressed in the raloxifene-treated groups. The multiplicity of lymph node metastasis was significantly decreased in the 27 mg/kg group. Levels of apoptosis were significantly increased in the raloxifene-treated groups, whereas the levels of DNA synthesis were significantly decreased in these groups. No differences in microvessel density in tumors were observed between the control and raloxifene-treated groups. The numbers of dilated lymphatic vessels containing intraluminal tumor cells were significantly reduced in mammary tumors in the raloxifene-treated groups. The levels of ERα mRNA in mammary tumors tended to be decreased in the raloxifene-treated groups. Conclusion These results suggest that the antimetastatic activity of raloxifene in mammary cancer expressing cytoplasmic ERα may be a crucial finding with clinical applications and that raloxifene may be useful as an adjuvant therapy and for the chemoprevention of breast cancer development.

  18. Motivations for the inmigration component of population turnaround in nonmetropolitan areas.

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    Williams, J D; Sofranko, A J

    1979-05-01

    Data from a 1977 survey of metropolitan and nonmetropolitan origin households migrating to 75 high net inmigration counties of the Midwest are examined to consider the motivational basis for the inmigration component of post-1970 nonmetropolitan migration trends. Findings suggest that the major stated motivations for leaving places of origin, especially among those from metropolitan areas, are "quality of life" considerations. Abouth a fourth of the metropolitan origin migrants' and half of the nonmetropolitan origin migrants' reasons are job-related. Anti-urban push and pro-rural pull responses are prevalent among migrants from metropolitan areas. Subsequent analysis of reasons for leaving metropolitan residences suggests consistency with other objective variables. Among households with a working-age head, those leaving for "quality of life" reasons came disproportionately from the largest metropolitan centers and went to the smallest towns. Those moving for non-employment reasons are not more likely to have taken an initial income loss, though they are less likely to experience immediate income gains.

  19. Modeling growth and dissemination of lymphoma in a co-evolving lymph node: a diffuse-domain approach

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    Chuang, Yao-Li; Cristini, Vittorio; Chen, Ying; Li, Xiangrong; Frieboes, Hermann; Lowengrub, John

    2013-03-01

    While partial differential equation models of tumor growth have successfully described various spatiotemporal phenomena observed for in-vitro tumor spheroid experiments, one challenge towards taking these models to further study in-vivo tumors is that instead of relatively static tissue culture with regular boundary conditions, in-vivo tumors are often confined in organ tissues that co-evolve with the tumor growth. Here we adopt a recently developed diffuse-domain method to account for the co-evolving domain boundaries, adapting our previous in-vitro tumor model for the development of lymphoma encapsulated in a lymph node, which may swell or shrink due to proliferation and dissemination of lymphoma cells and treatment by chemotherapy. We use the model to study the induced spatial heterogeneity, which may arise as an emerging phenomenon in experimental observations and model analysis. Spatial heterogeneity is believed to lead to tumor infiltration patterns and reduce the efficacy of chemotherapy, leaving residuals that cause cancer relapse after the treatment. Understanding the spatiotemporal evolution of in-vivo tumors can be an essential step towards more effective strategies of curing cancer. Supported by NIH-PSOC grant 1U54CA143907-01.

  20. Murine fibroblast growth factor receptor 1alpha isoforms mediate node regression and are essential for posterior mesoderm development.

    Science.gov (United States)

    Xu, X; Li, C; Takahashi, K; Slavkin, H C; Shum, L; Deng, C X

    1999-04-15

    Alternative splicing in the fibroblast growth factor receptor 1 (Fgfr1) locus generates a variety of splicing isoforms, including FGFR1alpha isoforms, which contain three immunoglobulin-like loops in the extracellular domain of the receptor. It has been previously shown that embryos carrying targeted disruptions of all major isoforms die during gastrulation, displaying severe growth retardation and defective mesodermal structures. Here we selectively disrupted the FGFR1alpha isoforms and found that they play an essential role in posterior mesoderm formation during gastrulation. We show that the mutant embryos lack caudal somites, develop spina bifida, and die at 9.5-12.5 days of embryonic development because they are unable to establish embryonic circulation. The primary defect is a failure of axial mesoderm cell migration toward the posterior portions of the embryos during gastrulation, as revealed by regional marker analysis and DiI labeling. In contrast, the anterior migration of the notochord is unaffected and the embryonic structures rostral to the forelimb are relatively normal. These data demonstrate that FGF/FGFR1alpha signals are posteriorizing factors that control node regression and posterior embryonic development.

  1. The Lymphatic Endothelial mCLCA1 Antibody Induces Proliferation and Growth of Lymph Node Lymphatic Sinuses.

    Directory of Open Access Journals (Sweden)

    Kimberly L Jordan-Williams

    Full Text Available Lymphocyte- and leukocyte-mediated lymph node (LN lymphatic sinus growth (lymphangiogenesis is involved in immune responses and in diseases including cancer and arthritis. We previously discovered a 10.1.1 Ab that recognizes the lymphatic endothelial cell (LEC surface protein mCLCA1, which is an interacting partner for LFA1 and Mac-1 that mediates lymphocyte adhesion to LECs. Here, we show that 10.1.1 Ab treatment specifically induces LEC proliferation, and influences migration and adhesion in vitro. Functional testing by injection of mice with 10.1.1 Ab but not control hamster Abs identified rapid induction of LN LEC proliferation and extensive lymphangiogenesis within 23 h. BrdU pulse-chase analysis demonstrated incorporation of proliferating LYVE-1-positive LEC into the growing medullary lymphatic sinuses. The 10.1.1 Ab-induced LN remodeling involved coordinate increases in LECs and also blood endothelial cells, fibroblastic reticular cells, and double negative stroma, as is observed during the LN response to inflammation. 10.1.1 Ab-induced lymphangiogenesis was restricted to LNs, as mCLCA1-expressing lymphatic vessels of the jejunum and dermis were unaffected by 23 h 10.1.1 Ab treatment. These findings demonstrate that 10.1.1 Ab rapidly and specifically induces proliferation and growth of LN lymphatic sinuses and stroma, suggesting a key role of mCLCA1 in coordinating LN remodeling during immune responses.

  2. Geographical imbalances: migration patterns of new graduate nurses and factors related to working in non-metropolitan hospitals.

    Science.gov (United States)

    Cho, Sung Hyun; Lee, Ji Yun; Mark, Barbara A; Lee, Han Yi

    2012-12-01

    To examine geographical imbalances by analyzing new graduate nurses' migration patterns among regions where they grew up, attended nursing school, and had their first employment and to identify factors related to working in non-metropolitan areas. The sample consisted of 507 new graduates working in hospitals as full-time registered nurses in South Korea. Migration patterns were categorized into 5 patterns based on sequential transitions of "geographic origin-nursing school-hospital." Multiple logistic regression analysis was conducted to identify factors associated with working in non-metropolitan hospitals. Nurses who grew up, graduated, and worked in the same region accounted for the greatest proportion (54%). Sixty-five percent had their first employment in the region where they graduated. Nurses tended to move from poor to rich regions and from non-metropolitan to metropolitan areas. Working in non-metropolitan hospitals was related to older age, the father having completed less than 4 years of college education, non-metropolitan origin, non-capital city school graduation, and a diploma (vs. baccalaureate) degree. Admitting students with rural backgrounds, increasing rural nursing school admission capacities, and providing service-requiring scholarships, particularly for students from low-income families, are recommended to address geographical imbalances.

  3. Node security

    CERN Document Server

    Barnes, Dominic

    2013-01-01

    A practical and fast-paced guide that will give you all the information you need to secure your Node applications.If you are a developer who wishes to secure your Node applications, whether you are already using Node Security in production, or are considering using it for your next project, then this book will enable you to ensure security of your applications. An understanding of JavaScript is a prerequisite, and some experience with Node is recommended, though not required.

  4. Node cookbook

    CERN Document Server

    Clements, David Mark

    2014-01-01

    In Node Cookbook Second Edition, each chapter focuses on a different aspect of working with Node. Following a Cookbook structure, the recipes are written in an easy-to-understand language. Readers will find it easier to grasp even the complex recipes which are backed by lots of illustrations, tips, and hints.If you have some knowledge of JavaScript and want to build fast, efficient, scalable client-server solutions, then Node Cookbook Second Edition is for you. Knowledge of Node will be an advantage but is not required. Experienced users of Node will be able to improve their skills.

  5. Value of Vocational Education and Training in a Non-Metropolitan Community. Project Summary. CRLRA Discussion Paper Series.

    Science.gov (United States)

    Toms, Jon; Falk, Ian; Kilpatrick, Sue

    A project has been designed to identify how a non-metropolitan community consolidates and develops sustainable social and economic activity. For many authors, the political position reiterating vocational education and training (VET) as the pivotal contributor to building national economic sustainability is framed in terms of human capital…

  6. Influence of Intimate Partner Violence on Domestic Relocation in Metropolitan and Non-Metropolitan Young Australian Women

    NARCIS (Netherlands)

    Dillon, Gina; Hussain, Rafat; Kibele, Eva; Rahman, Saifur; Loxton, Deborah

    2016-01-01

    Data from a national, population-based longitudinal study of Australian women (26-34 years) were analyzed to investigate the association between domestic relocation and multiple explanatory factors, namely intimate partner violence (IPV), metropolitan versus non-metropolitan residence, education, in

  7. Influence of Intimate Partner Violence on Domestic Relocation in Metropolitan and Non-Metropolitan Young Australian Women

    NARCIS (Netherlands)

    Dillon, Gina; Hussain, Rafat; Kibele, Eva; Rahman, Saifur; Loxton, Deborah

    2016-01-01

    Data from a national, population-based longitudinal study of Australian women (26-34 years) were analyzed to investigate the association between domestic relocation and multiple explanatory factors, namely intimate partner violence (IPV), metropolitan versus non-metropolitan residence, education,

  8. Invasive Cancer Incidence, 2004-2013, and Deaths, 2006-2015, in Nonmetropolitan and Metropolitan Counties - United States.

    Science.gov (United States)

    Henley, S Jane; Anderson, Robert N; Thomas, Cheryll C; Massetti, Greta M; Peaker, Brandy; Richardson, Lisa C

    2017-07-07

    Previous reports have shown that persons living in nonmetropolitan (rural or urban) areas in the United States have higher death rates from all cancers combined than persons living in metropolitan areas. Disparities might vary by cancer type and between occurrence and death from the disease. This report provides a comprehensive assessment of cancer incidence and deaths by cancer type in nonmetropolitan and metropolitan counties. 2004-2015. Cancer incidence data from CDC's National Program of Cancer Registries and the National Cancer Institute's Surveillance, Epidemiology, and End Results program were used to calculate average annual age-adjusted incidence rates for 2009-2013 and trends in annual age-adjusted incidence rates for 2004-2013. Cancer mortality data from the National Vital Statistics System were used to calculate average annual age-adjusted death rates for 2011-2015 and trends in annual age-adjusted death rates for 2006-2015. For 5-year average annual rates, counties were classified into four categories (nonmetropolitan rural, nonmetropolitan urban, metropolitan with population cancer site. Trends in rates were examined by county classification and cancer site. During the most recent 5-year period for which data were available, nonmetropolitan rural areas had lower average annual age-adjusted cancer incidence rates for all anatomic cancer sites combined but higher death rates than metropolitan areas. During 2006-2015, the annual age-adjusted death rates for all cancer sites combined decreased at a slower pace in nonmetropolitan areas (-1.0% per year) than in metropolitan areas (-1.6% per year), increasing the differences in these rates. In contrast, annual age-adjusted incidence rates for all cancer sites combined decreased approximately 1% per year during 2004-2013 both in nonmetropolitan and metropolitan counties. This report provides the first comprehensive description of cancer incidence and mortality in nonmetropolitan and metropolitan counties in

  9. Expression of vascular endothelial growth factor C and chemokine receptor CCR7 in gastric carcinoma and their values in predicting lymph node metastasis

    Institute of Scientific and Technical Information of China (English)

    Chao Yan; Hao-Ran Yin; Yan-Zhen Lin; Zheng-Gang Zhu; Ying-Yan Yu; Jun Ji; Yi Zhang; Yu-Bao Ji; Min Yan; Jun Chen; Bing-Ya Liu

    2004-01-01

    AIM: To study the expression of vascular endothelial growth factor C (VEGF-C) and chemokine receptor CCR7 in gastric carcinoma and to investigate their associations with lymph node metastasis of gastric carcinoma and their values in predicting lymph node metastasis.METHODS: The expression of VEGF-C and CCR7 in gastric carcinoma tissues obtained from 118 patients who underwent curative gastrectomy was examined by immunohistochemistry. Among these patients, 39 patients underwent multi-slice spiral CT (MSCT) examination.RESULTS: VEGF-C and CCR7 were positively expressed in 52.5 and 53.4% of patients. VEGF-C expression was more frequently found in tumors with lymph node metastasis than those without it (P<0.001). VEGF-C expression was also closely related to lymphatic invasion (P<0.001), vascular invasion (P<0.01), and TNM stage (P<0.001). However, there was no significant correlation between VEGF-C expression and age at surgery, gender, tumor size, tumor location, Lauren classification, and depth of invasion. CCR7 expression was significantly higher in patients with lymph node metastasis compared with those without lymph node metastasis (P<0.001) and was also associated with tumor size (P<0.01), depth of invasion (P<0.001), lymphatic invasion (P<0.001), and TNM stage (P<0.001). However, the presence of CCR7 had no correlation to age at surgery, gender, tumor location, Lauren classification, and vascular invasion. Among the 39 patients who underwent MSCT examination, only CCR7 expression was related to lymph node metastasis determined by MSCT (P<0.05). In the current retrospective study, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of VEGF-C and CCR7 expression in the diagnosis of lymph node metastasis for patients with gastric carcinoma were 73.8%, 70.2%, 72.6%, 71.4% and 72.0%, and 82.0%,77.2%, 79.4%, 80.0% and 79.7%, respectively. After subdivision according to the combination of

  10. Fast-Food Environments and Family Fast-Food Intake in Nonmetropolitan Areas

    Science.gov (United States)

    Longacre, Meghan R.; Drake, Keith M.; MacKenzie, Todd A.; Gibson, Lucinda; Owens, Peter; Titus, Linda J.; Beach, Michael L.; Dalton, Madeline A.

    2012-01-01

    Background Little is known about the influence of in-town fast-food availability on family-level fast-food intake in nonmetropolitan areas. Purpose The purpose of the current study was to determine whether the presence of chain fast-food outlets was associated with fast-food intake among adolescents and parents, and to assess whether this relationship was moderated by family access to motor vehicles. Methods Telephone surveys were conducted with 1547 adolescent–parent dyads in 32 New Hampshire and Vermont communities between 2007 and 2008. Fast-food intake in the past week was measured through self-report. In-town fast-food outlets were located and enumerated using an onsite audit. Family motor vehicle access was categorized based on the number of vehicles per licensed drivers in the household. Poisson regression was used to determine unadjusted and adjusted risk ratios (RRs). Analyses were conducted in 2011. Results About half (52.1%) of adolescents and 34.7% of parents consumed fast food at least once in the past week. Adolescents and parents who lived in towns with five or more fast-food outlets were about 30% more likely to eat fast food compared to those in towns with no fast-food outlets, even after adjusting for individual, family, and town characteristics (RR=1.29, 95% CI= 1.10, 1.51; RR=1.32, 95% CI=1.07,1.62, respectively). Interaction models demonstrated that the influence of in-town fast-food outlets on fast-food intake was strongest among families with low motor vehicle access. Conclusions In nonmetropolitan areas, household transportation should be considered as an important moderator of the relationship between in-town fast-food outlets and family intake. PMID:22608373

  11. Embedded Nanowire Network Growth and Node Device Fabrication for GaAs-Based High-Density Hexagonal Binary Decision Diagram Quantum Circuits

    Science.gov (United States)

    Tamura, Takahiro; Tamai, Isao; Kasai, Seiya; Sato, Taketomo; Hasegawa, Hideki; Hashizume, Tamotsu

    2006-04-01

    The basic feasibility of constructing hexagonal binary decision diagram (BDD) quantum circuits on GaAs-based selectively grown (SG) nanowires was investigated from viewpoints of electrical connections through embedded nanowires and electrical uniformity of devices formed on nanowires. For this, - and -oriented nanowires and hexagonal network structures combining these nanowires were formed on (001) GaAs substrates by selective molecular beam epitaxy (MBE) growth. The width and vertical position of the nanowires could be controlled by growth conditions for both - and -directions. By current-voltage (I-V) measurements, good electrical connection was confirmed at the node point where vertical alignment of embedded GaAs nanowire pieces was found to be important. SG quantum wire (QWR) switches formed on the nanowires showed good gate control over a wide temperature range with clear conductance quantization at low temperatures. Good device uniformities were obtained on the test chips, providing a good prospect for future integration. BDD node devices using SG QWR switches showed clear path switching characteristics. Estimated power-delay product values were very small, confirming the feasibility of ultra low-power operation of future circuits.

  12. Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model.

    Science.gov (United States)

    Xin, Xiping; Majumder, Mousumi; Girish, Gannareddy V; Mohindra, Vik; Maruyama, Takayuki; Lala, Peeyush K

    2012-08-01

    We reported that cyclo-oxygenase (COX)-2 expression in human breast cancer stimulated cancer cell migration and invasiveness, production of vascular endothelial growth factor (VEGF)-C and lymphangiogenesis in situ, largely from endogenous PGE2-mediated stimulation of prostaglandin E (EP)1 and EP4 receptors, presenting them as candidate therapeutic targets against lymphatic metastasis. As human breast cancer xenografts in immuno-compromised mice have limitations for preclinical testing, we developed a syngeneic murine breast cancer model of spontaneous lymphatic metastasis mimicking human and applied it for mechanistic and therapeutic studies. We tested the roles of COX-2 and EP receptors in VEGF-C and -D production by a highly metastatic COX-2 expressing murine breast cancer cell line C3L5. These cells expressed all EP receptors and produced VEGF-C and -D, both inhibited with COX-2 inhibitors or EP4 (but not EP1, EP2 or EP3) antagonists. C3H/HeJ mice, when implanted SC in both inguinal regions with C3L5 cells suspended in growth factor-reduced Matrigel, exhibited rapid tumor growth, tumor-associated angiogenesis and lymphangiogenesis (respectively measured with CD31 and LYVE-1 immunostaining), metastasis to the inguinal and axillary lymph nodes and the lungs. Chronic oral administration of COX-1/COX-2 inhibitor indomethacin, COX-2 inhibitor celecoxib and an EP4 antagonist ONO-AE3-208, but not an EP1 antagonist ONO-8713 at nontoxic doses markedly reduced tumor growth, lymphangiogenesis, angiogenesis, and metastasis to lymph nodes and lungs. Residual tumors in responding mice revealed reduced VEGF-C and -D proteins, AkT phosphorylation and increased apoptotic/proliferative cell ratios consistent with blockade of EP4 signaling. We suggest that EP4 antagonists deserve clinical testing for chemo-intervention of lymphatic metastasis in human breast cancer.

  13. Correlation between vascular endothelial growth factor expression and presence of lymph node metastasis in advanced squamous cell carcinoma of the larynx

    Directory of Open Access Journals (Sweden)

    Rodrigo Gonzalez Bonhin

    2015-02-01

    Full Text Available Introduction: Squamous cell carcinoma is the most common neoplasm of the larynx, and its evolution depends on tumor staging. Vascular endothelial growth factor is a marker of angiogenesis, and its expression may be related to increased tumor aggressiveness, as evidenced by the presence of cervical lymphatic metastases. Objectives: To evaluate the expression of the vascular endothelial growth factor marker in non-glottic advanced squamous cell carcinoma of the larynx (T3/T4 and correlate it with the presence of cervical lymph node metastases. Methods: Retrospective clinical study and immunohistochemical analysis of vascular endothelial growth factor through the German scale of immunoreactivity in products of non-glottic squamous cell carcinomas. Results: This study analyzed 15 cases of advanced non-glottic laryngeal tumors (T3/T4, four of which exhibited cervical lymphatic metastases. There was no correlation between vascular endothelial growth factor expression and the presence of cervical metastases. Conclusion: Although vascular endothelial growth factor was expressed in a few cases, there was no correlation with the spread of cervical lymph metastases.

  14. Comparison of the epidermal growth factor receptor protein expression between primary non-small cell lung cancer and paired lymph node metastases: implications for targeted nuclide radiotherapy

    Directory of Open Access Journals (Sweden)

    Zhang Chen

    2010-01-01

    Full Text Available Abstract Background The knowledge of Epidermal growth factor receptor (EGFR expression in metastases of NSCLC was limited. In receptor-mediated targeted nuclide radiotherapy, tumor cells are killed with delivered radiation and therapeutic efficiency is mainly dependent on the receptor expression. Thus, the level and stability of receptor expression in both primary tumors and corresponding metastases is crucial in the assessment of a receptor as target. The goal of this study was to evaluate whether EGFR is suitable as target for clinical therapy. Methods Expression of EGFR was investigated immunohistochemically in paired samples of lymph node metastases and corresponding NSCLC primary lesions (n = 51. EGFR expression was scored as 0, 1+, 2+ or 3+. Results Positive (1+, 2+ or 3+ EGFR immunostaining was evident in 36 of 47 (76.6% analysed NSCLC primary tumors, and in 78.7% of the corresponding lymph node metastases. When EGFR expression is classified as positive or negative, discordance between the primary tumors and the corresponding metastases was observed in 5 cases (10.6%. EGFR overexpression (2+ or 3+ was found in 53.2% (25/47 of the NSCLC primary tumors and 59.6% of the corresponding metastases. Nine out of the 47 paired samples (19.2% were discordant: Only three patients who had EGFR overexpression in the primary tumors showed EGFR downregulation (0 or 1+ in lymph node metastases, while six patients changed the other way around. Conclusions The EGFR expression in the primary tumor and the corresponding metastasis is discordant in about 10% of the patients. When overexpression is considered, the discordance is observed in about 20% of the cases. However, concerning EGFR overexpression in the primary tumors, similar expression in the metastases could be predicted with a reasonably high probability, which is encouraging for testing of EGFR targeted nuclide radiotherapy.

  15. A systematic review of professional supervision experiences and effects for allied health practitioners working in non-metropolitan health care settings

    Directory of Open Access Journals (Sweden)

    Ducat WH

    2015-08-01

    Full Text Available Wendy H Ducat,1,3 Saravana Kumar2 1Cunningham Centre, Darling Downs Hospital and Health Service, Australia; 2School of Health Sciences, International Centre for Allied Health Evidence, Sansom Institute, University of South Australia, Adelaide, SA, Australia; 3Rural Clinical School, School of Medicine, University of Queensland, Brisbane, QLD, Australia Introduction: In regional, rural, and remote settings, allied health professional supervision is one organizational mechanism designed to support and retain the workforce, provide clinical governance, and enhance service delivery. A systematic approach to evaluating the evidence of the experience and effects of professional supervision for non-metropolitan allied health practitioners and their service delivery is needed. Methods: Studies investigating the experience and effects of professional supervision across 17 allied health disciplines in non-metropolitan health services were systematically searched for using standardized keywords across seven databases. The initial search identified 1,574 references. Of these studies, five met inclusion criteria and were subject to full methodological appraisal by both reviewers. Two studies were primarily qualitative with three studies primarily quantitative in their approach. Studies were appraised using McMaster critical appraisal tools and data were extracted and synthesized. Results: Studies reported the context specific benefits and challenges of supervision in non-metropolitan areas and the importance of supervision in enhancing satisfaction and support in these areas. Comparison of findings between metropolitan and non-metropolitan settings within one study suggested that allied health in non-metropolitan settings were more satisfied with supervision though less likely to access it and preferred supervision with other non-metropolitan practitioners over access to more experienced supervisors. One study in a regional health service identified the lack

  16. Increasing incidence of neuroblastoma and potentially higher associated mortality of children from nonmetropolitan areas: analysis of the surveillance, epidemiology, and end results database.

    Science.gov (United States)

    Hsieh, Michael H; Meng, Maxwell V; Walsh, Thomas J; Matthay, Katherine K; Baskin, Laurence S

    2009-12-01

    Geographic variations in cancer incidence and mortality can yield clues regarding etiology and healthcare access. We examined pediatric neuroblastoma incidence and mortality in metropolitan counties (containing a core urban area of 50,000 or more people) versus nonmetropolitan counties. We identified cases through the Surveillance, Epidemiology, and End Results database. We analyzed age, race, sex, year of diagnosis, mortality, and county type (metropolitan or nonmetropolitan). In total, 1777 neuroblastoma cases were identified. From 1973 to 2003, the incidence of pediatric neuroblastoma in nonmetropolitan counties has risen from 0.8 to 1.2 cases per 100,000 person-years (annual percent change, 2.09%, Prank test P=0.0357]. The incidence of pediatric neuroblastoma in nonmetropolitan counties seems to be increasing, possibly due to demographic or environmental factors. Mortality seems to be higher in children from nonmetropolitan versus metropolitan counties. However, this study is limited by sample size. These concerning trends warrant further study through means other than Surveillance, Epidemiology, and End Results.

  17. Sentinel Lymph Node Biopsy

    Science.gov (United States)

    ... Ask about Your Diagnosis Research Sentinel Lymph Node Biopsy On This Page What are lymph nodes? What ... lymph node? What is a sentinel lymph node biopsy? What happens during an SLNB? What are the ...

  18. Lymph node biopsy

    Science.gov (United States)

    Biopsy - lymph nodes; Open lymph node biopsy; Fine needle aspiration biopsy; Sentinel lymph node biopsy ... A lymph node biopsy is done in an operating room in a hospital. Or, it is done at an outpatient surgical center. The ...

  19. Reconfigureable network node

    Science.gov (United States)

    Vanderveen, Keith B.; Talbot, Edward B.; Mayer, Laurence E.

    2008-04-08

    Nodes in a network having a plurality of nodes establish communication links with other nodes using available transmission media, as the ability to establish such links becomes available and desirable. The nodes predict when existing communications links will fail, become overloaded or otherwise degrade network effectiveness and act to establish substitute or additional links before the node's ability to communicate with the other nodes on the network is adversely affected. A node stores network topology information and programmed link establishment rules and criteria. The node evaluates characteristics that predict existing links with other nodes becoming unavailable or degraded. The node then determines whether it can form a communication link with a substitute node, in order to maintain connectivity with the network. When changing its communication links, a node broadcasts that information to the network. Other nodes update their stored topology information and consider the updated topology when establishing new communications links for themselves.

  20. Reconfigureable network node

    Energy Technology Data Exchange (ETDEWEB)

    Vanderveen, Keith B. (Tracy, CA); Talbot, Edward B. (Livermore, CA); Mayer, Laurence E. (Davis, CA)

    2008-04-08

    Nodes in a network having a plurality of nodes establish communication links with other nodes using available transmission media, as the ability to establish such links becomes available and desirable. The nodes predict when existing communications links will fail, become overloaded or otherwise degrade network effectiveness and act to establish substitute or additional links before the node's ability to communicate with the other nodes on the network is adversely affected. A node stores network topology information and programmed link establishment rules and criteria. The node evaluates characteristics that predict existing links with other nodes becoming unavailable or degraded. The node then determines whether it can form a communication link with a substitute node, in order to maintain connectivity with the network. When changing its communication links, a node broadcasts that information to the network. Other nodes update their stored topology information and consider the updated topology when establishing new communications links for themselves.

  1. Ultrasonography-Guided Core Biopsy of Supraclavicular Lymph Nodes for Diagnosis of Metastasis and Identification of Epidermal Growth Factor Receptor (EGFR) Mutation in Advanced Lung Cancer.

    Science.gov (United States)

    Choe, Jooae; Kim, Mi Young; Baek, Jung Hwan; Choi, Chang-Min; Kim, Hwa Jung

    2015-07-01

    The aim of this study was to evaluate the diagnostic performance of ultrasonography (US)-guided core biopsy of a supraclavicular lymph node (SCN) for detecting metastasis and epidermal growth factor receptor (EGFR) mutations. We included 229 patients who underwent US-guided core biopsy of SCN with lung cancer from January 2011 to December 2013. We evaluated the morphologic characteristics and measured the sizes of SCNs on US and chest computed tomography (CT). The clinical stage, maximum standardized uptake value (SUV max) on 18F-fluorodeoxyglucose positron emission tomography, and the morphology on US and CT in the positive metastasis were compared with those in the negative metastasis. The prevalence of EGFR mutations of the adenocarcinoma and procedure-related complication was investigated. The accuracy of US-guided core biopsy of SCN diagnosing metastasis was 97.8% (224/229). The cutoff values (sensitivity; specificity; area under the receiver operating characteristic curve, 95% confidence interval [CI]) of the short-axis dimension of SCN on CT were 0.85 cm (72.3%; 80.6%; 0.808, 95% CI: 0.740-0.875), on US 0.75 cm (73.5%; 84.8%; 0.843, 95% CI: 0.788-0.897), and that of SUV max 4.05 (79.1%; 81.8%; 0.853, 95% CI: 0.780-0.925). The mutations were positive in 35.8% with adenocarcinoma. There were no procedure-related complications of US-guided SCN core biopsy. US-guided SCN core biopsy is a reliable and safe method for detecting metastasis, histologic subtyping, and identifying the EGFR mutation in the advanced lung cancers. It may be a substitute for more invasive lung biopsy as an initial tissue confirmation in the advanced disease.

  2. Shopper-Based Mall Equity: A Comparative Study of Metropolitan and Non-Metropolitan Area in Malaysia

    Directory of Open Access Journals (Sweden)

    Abdul Rahman Zahari

    2012-12-01

    Full Text Available The purpose of this study is to differentiate the role of generation Y on dimensions of shopper-based mall equity (SBME for two different locations in Malaysia. SBME is the differential effect of mall knowledge on shoppers' responses to a mall's marketing activities. We validated the shopper-based mall equity measure using data generated with mall-intercept surveys in two shopping malls in Malaysia located at Kuantan, Pahang (non-metropolitan area, while Petaling Jaya, Selangor represent metropolitan area (N=564. The data collected then was analyzed using exploratory factor analysis, reliability test, descriptive statistics, and t-test. The results from t-test show that the variables i.e. mall awareness, mall environment, mall convenience, mall entertainment, and mall equity have significant difference between two selected malls. However the effect sizes (eta squared were small. Moreover, product/service quality, service quality, and mall loyalty have no significant difference between two malls.

  3. Atrial Fibrillation Screening in Nonmetropolitan Areas Using a Telehealth Surveillance System With an Embedded Cloud-Computing Algorithm: Prospective Pilot Study.

    Science.gov (United States)

    Chen, Ying-Hsien; Hung, Chi-Sheng; Huang, Ching-Chang; Hung, Yu-Chien; Hwang, Juey-Jen; Ho, Yi-Lwun

    2017-09-26

    Atrial fibrillation (AF) is a common form of arrhythmia that is associated with increased risk of stroke and mortality. Detecting AF before the first complication occurs is a recognized priority. No previous studies have examined the feasibility of undertaking AF screening using a telehealth surveillance system with an embedded cloud-computing algorithm; we address this issue in this study. The objective of this study was to evaluate the feasibility of AF screening in nonmetropolitan areas using a telehealth surveillance system with an embedded cloud-computing algorithm. We conducted a prospective AF screening study in a nonmetropolitan area using a single-lead electrocardiogram (ECG) recorder. All ECG measurements were reviewed on the telehealth surveillance system and interpreted by the cloud-computing algorithm and a cardiologist. The process of AF screening was evaluated with a satisfaction questionnaire. Between March 11, 2016 and August 31, 2016, 967 ECGs were recorded from 922 residents in nonmetropolitan areas. A total of 22 (2.4%, 22/922) residents with AF were identified by the physician's ECG interpretation, and only 0.2% (2/967) of ECGs contained significant artifacts. The novel cloud-computing algorithm for AF detection had a sensitivity of 95.5% (95% CI 77.2%-99.9%) and specificity of 97.7% (95% CI 96.5%-98.5%). The overall satisfaction score for the process of AF screening was 92.1%. AF screening in nonmetropolitan areas using a telehealth surveillance system with an embedded cloud-computing algorithm is feasible.

  4. Differences in Human Papillomavirus Vaccination Among Adolescent Girls in Metropolitan Versus Non-metropolitan Areas: Considering the Moderating Roles of Maternal Socioeconomic Status and Health Care Access

    Science.gov (United States)

    Rhubart, Danielle C.; Wallington, Sherrie Flynt

    2015-01-01

    Objectives This study is among the first to examine metropolitan status differences in human papillomavirus (HPV) vaccine initiation and completion among United States adolescent girls and is unique in its focus on how maternal socioeconomic status and health care access moderate metropolitan status differences in HPV vaccination. Methods Using cross-sectional data from 3573 girls aged 12–17 in the U.S. from the 2008–2010 Behavioral Risk Factor Surveillance System, we estimate main and interaction effects from binary logistic regression models to identify subgroups of girls for which there are metropolitan versus non-metropolitan differences in HPV vaccination. Results Overall 34 % of girls initiated vaccination, and 19 % completed all three shots. On average, there were no metropolitan status differences in vaccination odds. However, there were important subgroup differences. Among low-income girls and girls whose mothers did not complete high school, those in non-metropolitan areas had significantly higher probability of vaccine initiation than those in metropolitan areas. Among high-income girls and girls whose mothers completed college, those in metropolitan areas had significantly higher odds of vaccine initiation than those in non-metropolitan areas. Moreover, among girls whose mothers experienced a medical cost barrier, non-metropolitan girls were less likely to initiate vaccination compared to metropolitan girls. Conclusions Mothers remain essential targets for public health efforts to increase HPV vaccination and combat cervical cancer. Public health experts who study barriers to HPV vaccination and physicians who come into contact with mothers should be aware of group-specific barriers to vaccination and employ more tailored efforts to increase vaccination. PMID:26511129

  5. Sentinel node biopsy (image)

    Science.gov (United States)

    Sentinel node biopsy is a technique which helps determine if a cancer has spread (metastasized), or is contained locally. When a ... is closest to the cancer site. Sentinel node biopsy is used to stage many kinds of cancer, ...

  6. Modular sensor network node

    Science.gov (United States)

    Davis, Jesse Harper Zehring; Stark, Jr., Douglas Paul; Kershaw, Christopher Patrick; Kyker, Ronald Dean

    2008-06-10

    A distributed wireless sensor network node is disclosed. The wireless sensor network node includes a plurality of sensor modules coupled to a system bus and configured to sense a parameter. The parameter may be an object, an event or any other parameter. The node collects data representative of the parameter. The node also includes a communication module coupled to the system bus and configured to allow the node to communicate with other nodes. The node also includes a processing module coupled to the system bus and adapted to receive the data from the sensor module and operable to analyze the data. The node also includes a power module connected to the system bus and operable to generate a regulated voltage.

  7. Multiple node remote messaging

    Energy Technology Data Exchange (ETDEWEB)

    Blumrich, Matthias A. (Ridgefield, CT); Chen, Dong (Croton on Hudson, NY); Gara, Alan G. (Mount Kisco, NY); Giampapa, Mark E. (Irvington, NY); Heidelberger, Philip (Cortlandt Manor, NY); Ohmacht, Martin (Yorktown Heights, NY); Salapura, Valentina (Chappaqua, NY); Steinmacher-Burow, Burkhard (Esslingen, DE); Vranas, Pavlos (Danville, CA)

    2010-08-31

    A method for passing remote messages in a parallel computer system formed as a network of interconnected compute nodes includes that a first compute node (A) sends a single remote message to a remote second compute node (B) in order to control the remote second compute node (B) to send at least one remote message. The method includes various steps including controlling a DMA engine at first compute node (A) to prepare the single remote message to include a first message descriptor and at least one remote message descriptor for controlling the remote second compute node (B) to send at least one remote message, including putting the first message descriptor into an injection FIFO at the first compute node (A) and sending the single remote message and the at least one remote message descriptor to the second compute node (B).

  8. Related Drupal Nodes Block

    NARCIS (Netherlands)

    Van der Vegt, Wim

    2010-01-01

    Related Drupal Nodes Block This module exposes a block that uses Latent Semantic Analysis (Lsa) internally to suggest three nodes that are relevant to the node a user is viewing. This module performs three tasks. 1) It periodically indexes a Drupal site and generates a Lsa Term Document Matrix. Inde

  9. Live and Dead Nodes

    DEFF Research Database (Denmark)

    Jørgensen, Sune Lehman; Jackson, A. D.

    2005-01-01

    In this paper, we explore the consequences of a distinction between `live' and `dead' network nodes; `live' nodes are able to acquire new links whereas `dead' nodes are static. We develop an analytically soluble growing network model incorporating this distinction and show that it can provide a q...

  10. Related Drupal Nodes Block

    NARCIS (Netherlands)

    Van der Vegt, Wim

    2010-01-01

    Related Drupal Nodes Block This module exposes a block that uses Latent Semantic Analysis (Lsa) internally to suggest three nodes that are relevant to the node a user is viewing. This module performs three tasks. 1) It periodically indexes a Drupal site and generates a Lsa Term Document Matrix. Inde

  11. Impact of technical expertise in a nonmetropolitan siting dispute: a case study of the Hersey WFPP controversy

    Energy Technology Data Exchange (ETDEWEB)

    Frankena, F.

    1983-01-01

    This research study further illuminates public response to the scale of energy-resource development by examination of a case involving a renewable energy technology - a 25-MW wood-fired electric power plant (WFPP) to have been sited in the remote nonmetropolitan Michigan community of Hersey. The controversy began late in 1978 shortly after the three prime sites were announced and concluded in 1980 when the proposal was withdrawn in the face of a local hazardous and toxic waste ordinance. Offers followed from other communities while opposition continued to develop throughout the region. Using a case history approach that relies on a variety of data sources complemented by a content analysis of the Hersey site hearing and accounts from the local newspaper, this study focuses on a number of the salient issues of power plant siting. Foremost among these is the social and political impact of technical expertise. Expertise is evaluated in terms of facts/values and local/cosmopolitan orientations. Content analysis was also applied to the issues in the controversy. Policy implications are discussed for scale and centralization in energy development, the concomitant distribution of costs, and the use of technical expertise as a tool to depoliticize issues. This study suggests that public concerns relative to the scale of energy development may not be allayed by continued resort to expertise alone.

  12. Intramammary lymph nodes.

    Science.gov (United States)

    Egan, R L; McSweeney, M B

    1983-05-15

    Radiographic, gross, and histopathologic studies on 158 whole breasts with primary operable carcinoma revealed intramammary lymph nodes in 28%, and of these breasts, 10% contained a metastatic deposit of carcinoma. Cancerous and noncancerous nodes were found in all quadrants of the breast with the positive ones being in the same quadrant as the carcinoma only 50% of the time. There was no demonstrable connection with the usual lymphatic drainage of the breast. With Stage II carcinoma, positive intramammary lymph nodes had no direct effect on prognosis, merely representing advanced disease and indicating a greater likelihood of axillary metastatic disease. There was a trend toward poorer prognosis in Stage I lesions with positive intramammary lymph nodes. This may indicate the Stage I carcinomas that have a similar prognosis as Stage II tumors. Conceivably, a Stage Ia, positive intramammary lymph node(s) but normal axillary lymph nodes, could be defined and used.

  13. Otiy: Loactors tracking nodes

    CERN Document Server

    Boc, Mathias; de Amorim, Marcelo dias

    2007-01-01

    We propose Otiy, a node-centric location service that limits the impact of location updates generate by mobile nodes in IEEE802.11-based wireless mesh networks. Existing location services use node identifiers to determine the locator (aka anchor) that is responsible for keeping track of a node's location. Such a strategy can be inefficient because: (i) identifiers give no clue on the node's mobility and (ii) locators can be far from the source/destination shortest path, which increases both location delays and bandwidth consumption. To solve these issues, Otiy introduces a new strategy that identifies nodes to play the role of locators based on the likelihood of a destination to be close to these nodes- i.e., locators are identified depending on the mobility pattern of nodes. Otiy relies on the cyclic mobility patterns of nodes and creates a slotted agenda composed of a set of predicted locations, defined according to the past and present patterns of mobility. Correspondent nodes fetch this agenda only once a...

  14. Deploying Node.js

    CERN Document Server

    Pasquali, Sandro

    2015-01-01

    If you are an intermediate or advanced developer deploying your Node.js applications, then this book is for you. If you have already built a Node application or module and want to take your knowledge to the next level, this book will help you find your way.

  15. Gene expression profiles associated with the presence of a fibrotic focus and the growth pattern in lymph node-negative breast cancer

    NARCIS (Netherlands)

    G. van den Eynden; M. Smid (Marcel); S.J. van Laere (Steven); C.G. Colpaert (Cecile); U.D. van Auwera; T.X. Bich; P. van Dam (Peter); M.A. den Bakker (Michael); L.Y. Dirix (Luc); E.A. van Marck (Eric); P.B. Vermeulen; J.A. Foekens (John)

    2008-01-01

    textabstractPurpose: A fibrotic focus, the scar-like area found in the center of an invasive breast tumor, is a prognostic parameter associated with an expansive growth pattern, hypoxia, and (lymph) angiogenesis. Little is known about the molecular pathways involved. Experimental Design: Sixty-five

  16. Swollen lymph nodes

    Science.gov (United States)

    ... gingivitis ) Mononucleosis Mouth sores Sexually transmitted illness (STI) Tonsillitis Tuberculosis Skin infections Immune or autoimmune disorders that ... goes away in a couple of days, without treatment. The lymph node may not return to its ...

  17. Lymph node culture

    Science.gov (United States)

    Culture - lymph node ... or viruses grow. This process is called a culture. Sometimes, special stains are also used to identify specific cells or microorganisms before culture results are available. If needle aspiration does not ...

  18. Lesson Nine Sinus node dysfunction

    Institute of Scientific and Technical Information of China (English)

    鲁端; 吴文烈

    2004-01-01

    @@ Sinus node dysfunction most often is found in the elderly as an isolated phenomenon. Although interruption of the blood supply to the sinus node may produce dysfunction, the correlation between obstruction of the sinus node artery and clinical evidence of sinus node dysfunction is poor.

  19. Instant node package module

    CERN Document Server

    Ali, Juzer

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. A practical exploration of the lifecycle of creating node modules as well as learning all of the top features that npm has to offer.Intended for readers who want to create their first node.js modules. The programming paradigm of JavaScript is not covered so a foundation in these concepts would be beneficial.

  20. Proof of node densities

    NARCIS (Netherlands)

    Klein Wolterink, W.; Heijenk, G.; Berg, van den J.L.

    2012-01-01

    In this paper we present an analytical model accurately describing the forwarding behaviour of a multi-hop broadcast protocol. Our model covers the scenario in which a message is forwarded over a straight road and inter-node distances are distributed exponentially. Intermediate forwarders draw a sma

  1. [Effect of 21-gene recurrence score on chemotherapy decisions for patients with estrogen receptor-positive, epidermal growth factor receptor 2-negative and lymph node-negative early stage-breast cancer].

    Science.gov (United States)

    Mao, Y; Chen, X S; Liang, Y; Wu, J Y; Huang, O; Zong, Y; Fang, Q; He, J R; Zhu, L; Chen, W G; Li, Y F; Lin, L; Fei, X C; Shen, K W

    2017-07-23

    Objective: To investigate the effect of 21-gene recurrence score on adjuvant chemotherapy decisions for patients with estrogen receptor (ER)-positive, epidermal growth factor receptor 2 (HER-2)-negative and lymph node (LN)-negative early stage-breast cancer. Methods: One hundred and forty-eight patients with ER+ , HER-2- and LN- early stage breast cancer were recruited in the Ruijin hospital, Shanghai Jiao Tong University School of Medicine. The 21-gene recurrence score (RS)assay was performed and systemic therapeutic decisions were made before and after knowing the RS results under multidisciplinary discussion. The effects of RS assay and the other influential factors on adjuvant chemotherapy decision were further analyzed. Results: After knowing the RS results, treatment decisions were changed in 26 out of 148 patients(17.6%). Among them, 9 out of 26 patients were not recommended for chemotherapy; 16 of 26 had treatment recommendation changed to chemotherapy, and chemotherapy regimen was changed in the last one patient. Multivariate analysis showed that RS, age and histological grade were independent factors of decision-making for adjuvant chemotherapy. Conclusion: Our results suggest that 21-gene recurrence score significantly influences decision making for adjuvant chemotherapy in patients with ER+ , HER-2- and LN- early stage breast cancer.

  2. α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation

    Directory of Open Access Journals (Sweden)

    Okuno Yasushi

    2011-06-01

    Full Text Available Abstract Background The mangosteen fruit has a long history of medicinal use in Chinese and Ayurvedic medicine. Recently, the compound α-mangostin, which is isolated from the pericarp of the fruit, was shown to induce cell death in various types of cancer cells in in vitro studies. This led us to investigate the antitumor growth and antimetastatic activities of α-mangostin in an immunocompetent xenograft model of mouse metastatic mammary cancer having a p53 mutation that induces a metastatic spectrum similar to that seen in human breast cancers. Methods Mammary tumors, induced by inoculation of BALB/c mice syngeneic with metastatic BJMC3879luc2 cells, were subsequently treated with α-mangostin at 0, 10 and 20 mg/kg/day using mini-osmotic pumps and histopathologically examined. To investigate the mechanisms of antitumor ability by α-mangostin, in vitro studies were also conducted. Results Not only were in vivo survival rates significantly higher in the 20 mg/kg/day α-mangostin group versus controls, but both tumor volume and the multiplicity of lymph node metastases were significantly suppressed. Apoptotic levels were significantly increased in the mammary tumors of mice receiving 20 mg/kg/day and were associated with increased expression of active caspase-3 and -9. Other significant effects noted at this dose level were decreased microvessel density and lower numbers of dilated lymphatic vessels containing intraluminal tumor cells in mammary carcinoma tissues. In vitro, α-mangostin induced mitochondria-mediated apoptosis and G1-phase arrest and S-phase suppression in the cell cycle. Since activation by Akt phosphorylation plays a central role in a variety of oncogenic processes, including cell proliferation, anti-apoptotic cell death, angiogenesis and metastasis, we also investigated alterations in Akt phosphorylation induced by α-mangostin treatment both in vitro and in vivo. Quantitative analysis and immunohistochemistry showed that

  3. Node seniority ranking

    CERN Document Server

    Fioriti, Vincenzo

    2014-01-01

    Recent advances in graph theory suggest that is possible to identify the oldest nodes of a network using only the graph topology. Here we report on applications to heterogeneous real world networks. To this end, and in order to gain new insights, we propose the theoretical framework of the Estrada communicability. We apply it to two technological networks (an underground, the diffusion of a software worm in a LAN) and to a third network representing a cholera outbreak. In spite of errors introduced in the adjacency matrix of their graphs, the identification of the oldest nodes is feasible, within a small margin of error, and extremely simple. Utilizations include the search of the initial disease-spreader (patient zero problem), rumors in social networks, malware in computer networks, triggering events in blackouts, oldest urban sites recognition.

  4. One node driving synchronisation.

    Science.gov (United States)

    Wang, Chengwei; Grebogi, Celso; Baptista, Murilo S

    2015-12-11

    Abrupt changes of behaviour in complex networks can be triggered by a single node. This work describes the dynamical fundamentals of how the behaviour of one node affects the whole network formed by coupled phase-oscillators with heterogeneous coupling strengths. The synchronisation of phase-oscillators is independent of the distribution of the natural frequencies, weakly depends on the network size, but highly depends on only one key oscillator whose ratio between its natural frequency in a rotating frame and its coupling strength is maximum. This result is based on a novel method to calculate the critical coupling strength with which the phase-oscillators emerge into frequency synchronisation. In addition, we put forward an analytical method to approximately calculate the phase-angles for the synchronous oscillators.

  5. One node driving synchronisation

    CERN Document Server

    Wang, Chengwei; Baptista, Murilo S

    2015-01-01

    Abrupt changes of behaviour in complex networks can be triggered by a single node. This work describes the dynamical fundamentals of how the behaviour of one node affects the whole network formed by coupled phase-oscillators with heterogeneous coupling strengths. The synchronisation of phase-oscillators is independent of the distribution of the natural frequencies, weakly depends on the network size, but highly depends on only one key oscillator whose ratio between its natural frequency in a rotating frame and its coupling strength is maximum. This result is based on a novel method to calculate the critical coupling strength with which the phase-oscillators emerge into frequency synchronisation. In addition, we put forward an analytical method to approximately calculate the phase-angles for the synchronous oscillators.

  6. Involved Node Radiation Therapy

    DEFF Research Database (Denmark)

    Maraldo, Maja V; Aznar, Marianne C; Vogelius, Ivan R

    2012-01-01

    PURPOSE: The involved node radiation therapy (INRT) strategy was introduced for patients with Hodgkin lymphoma (HL) to reduce the risk of late effects. With INRT, only the originally involved lymph nodes are irradiated. We present treatment outcome in a retrospective analysis using this strategy...... to 36 Gy). Patients attended regular follow-up visits until 5 years after therapy. RESULTS: The 4-year freedom from disease progression was 96.4% (95% confidence interval: 92.4%-100.4%), median follow-up of 50 months (range: 4-71 months). Three relapses occurred: 2 within the previous radiation field......, and 1 in a previously uninvolved region. The 4-year overall survival was 94% (95% confidence interval: 88.8%-99.1%), median follow-up of 58 months (range: 4-91 months). Early radiation therapy toxicity was limited to grade 1 (23.4%) and grade 2 (13.8%). During follow-up, 8 patients died, none from HL, 7...

  7. Node web development

    CERN Document Server

    Herron, David

    2013-01-01

    Presented in a simple, step-by-step format, this book is an introduction to web development with Node.This book is for anybody looking for an alternative to the ""P"" languages (Perl, PHP, Python), or anyone looking for a new paradigm of server-side application development.The reader should have at least a rudimentary understanding of JavaScript and web application development.

  8. Node Classification in Social Networks

    Science.gov (United States)

    Bhagat, Smriti; Cormode, Graham; Muthukrishnan, S.

    When dealing with large graphs, such as those that arise in the context of online social networks, a subset of nodes may be labeled. These labels can indicate demographic values, interest, beliefs or other characteristics of the nodes (users). A core problem is to use this information to extend the labeling so that all nodes are assigned a label (or labels).

  9. Dynamics of excitable nodes on random graphs

    Indian Academy of Sciences (India)

    K Manchanda; T Umeshkanta Singh; R Ramaswamy

    2011-11-01

    We study the interplay of topology and dynamics of excitable nodes on random networks. Comparison is made between systems grown by purely random (Erd˝os–Rényi) rules and those grown by the Achlioptas process. For a given size, the growth mechanism affects both the thresholds for the emergence of different structural features as well as the level of dynamical activity supported on the network.

  10. The role of long distance migration in the rural renaissance, in gentrification, and in growth of the Sunbelt.

    Science.gov (United States)

    Serow, W J

    1980-01-01

    The author "has examined trends in interstate migration during the 1970s for the four regions of the United States and, in particular, explored the relationship of this migration with nonmetropolitan expansion and the return to the city movement. The data show that the former trend is a very real one which has persisted throughout the decade and that population growth through interstate migration in nonmetropolitan America is, on balance, the result of nonblacks moving to the South from elsewhere in the nation. Except in the West, central cities continue to experience substantial losses of population through interstate migration. Interstate migration continues to be directed toward suburbs, and is especially vigorous in the West." Data are from the March 1975 and March 1979 Current Population Surveys.

  11. Node Clustering for Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Sania Bhatti

    2012-01-01

    Full Text Available Recent years have witnessed considerable growth in the development and deployment of clustering methods which are not only used to maintain network resources but also increases the reliability of the WSNs (Wireless Sensor Network and the facts manifest by the wide range of clustering solutions. Node clustering by selecting key parameters to tackle the dynamic behaviour of resource constraint WSN is a challenging issue. This paper highlights the recent progress which has been carried out pertaining to the development of clustering solutions for the WSNs. The paper presents classification of node clustering methods and their comparison based on the objectives, clustering criteria and methodology. In addition, the potential open issues which need to be considered for future work are high lighted.

  12. NRC/UBC Node

    Energy Technology Data Exchange (ETDEWEB)

    Ellis-Perry, B. [Univ. of British Columbia, Vancouver, British Columbia (Canada); Yogendran, Y. [NRC Inst. for Fuel Cell Innovation, Vancouver, British Columbia (Canada)

    2004-07-01

    'Full text:' In the search for cleaner, more sustainable energy sources, many of the most promising breakthroughs have been in hydrogen technology. However, this promise will remain unfulfilled without public interest and enthusiasm, and without the infrastructure to support the technology. In order to get there, we have to test, perfect, and demonstrate technology that is safe and affordable, and we must do so in practical, familiar settings. Ideally, such settings should be easily accessible to the engineers, planners, and architects of tomorrow while providing a showcase for hydrogen technology that will attract the general public. This place is the NRC/UBC Hydrogen Node. The UBC campus in Point Grey is home to leading edge, internationally recognized researchers in a range of disciplines, both within the University and at the NRC Institute for Fuel Cell Innovation. On average, 40,000 students, faculty, and staff use the campus every day; UBC graduates go on to leadership positions in communities around the globe. Its spectacular setting makes UBC a popular destination for thousands of visitors from around the world. In 2006 UBC will host the World Urban Forum, and in 2010 it will be one of the sites for the Vancouver-Whistler Olympic Games. UBC and its South Campus neighbourhoods are developing as a model sustainable community, offering an excellent opportunity to develop and showcase hydrogen infrastructure and technology in a real-life, attractive setting that will be seen by thousands of people around the world. UBC's facilities, location, and Trek 2010 commitment to excellence in learning, research, and sustainability make it an ideal location for such a project. The H2 Village at UBC will be an integrated hydrogen demonstration project, linked to the hydrogen highway. This project is bringing together leading companies, researchers, and government agencies committed to making the refinement and early adoption of safe hydrogen technology a

  13. Smart Home Wireless Sensor Nodes

    DEFF Research Database (Denmark)

    Lynggaard, Per

    . This paper introduces an approach that considerably lowers the wireless sensor node power consumption and the amount of transmitted sensor events. It uses smart objects that include artificial intelligence to efficiently process the sensor event on location and thereby saves the costly wireless......Smart homes are further development of intelligent buildings and home automation, where context awareness and autonomous behaviour are added. They are based on a combination of the Internet and emerging technologies like wireless sensor nodes. These wireless sensor nodes are challenging because...

  14. A local-world node deleting evolving network model

    Energy Technology Data Exchange (ETDEWEB)

    Gu Yuying [Department of Mathematics, Tongji University, Shanghai 200092 (China); Sun Jitao [Department of Mathematics, Tongji University, Shanghai 200092 (China)], E-mail: sunjt@sh163.net

    2008-06-16

    A new type network growth rule which comprises node addition with the concept of local-world connectivity and node deleting is studied. A series of theoretical analysis and numerical simulation to the LWD network are conducted in this Letter. Firstly, the degree distribution p(k) of this network changes no longer pure scale free but truncates by an exponential tail and the truncation in p(k) increases as p{sub a} decreases. Secondly, the connectivity is tighter, as the local-world size M increases. Thirdly, the average path length L increases and the clustering coefficient decreases as generally node deleting increases. Finally, trends up when the local-world size M increases, so as to k{sub max}. Hence, the expanding local-world can compensate the infection of the node deleting.

  15. The Sentinel Lymph Node Concept

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    The sentinel lymph node concept is meeting with steadily growing interest and is being extended to the different sites of the primaries. In addition, the concept is being applied in an increasingly sophisticated manner. In this book the practical

  16. Mesenteric lymph node cavitation syndrome

    Institute of Scientific and Technical Information of China (English)

    Hugh; James; Freeman

    2010-01-01

    The mesenteric lymph node cavitation syndrome consists of central necrosis of mesenteric lymph nodes and may occur with either celiac disease or a sprue-like intestinal disease that fails to respond to a gluten-free diet. Splenic hypofunction may also be present. The cause is not known but its development during the clinical course of celiac disease is usually indicative of a poor prognosis for the intestinal disorder, a potential for signif icant compli-cations including sepsis and malignancy, particularly...

  17. Immunolymphoscintigraphy for Metastatic Sentinel Nodes

    DEFF Research Database (Denmark)

    Chakera, A.H.; Nielsen, B.S.; Madsen, J.;

    2011-01-01

    Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune- deficient (nude) mice with xenograft human...... in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging....

  18. Sentinel Node Biopsy Alone versus Completion Axillary Node Dissection in Node Positive Breast Cancer: Systematic Review and Meta-Analysis

    OpenAIRE

    Rachna Ram; Jasprit Singh; Eddie McCaig

    2014-01-01

    Introduction. There has been recent interest in validity of completion axillary node dissection after a positive sentinel node. This systematic review aims to ascertain if sentinel lymph node dissection alone was noninferior to axillary lymph node dissection for breast cancer patients who have a positive sentinel node. Method. A systematic review of the electronic databases Embase, MEDLINE, and Cochrane Register of Controlled Trials was carried out. Only randomised trials that had patients wi...

  19. Swiss EMBnet node web server.

    Science.gov (United States)

    Falquet, Laurent; Bordoli, Lorenza; Ioannidis, Vassilios; Pagni, Marco; Jongeneel, C Victor

    2003-07-01

    EMBnet is a consortium of collaborating bioinformatics groups located mainly within Europe (http://www.embnet.org). Each member country is represented by a 'node', a group responsible for the maintenance of local services for their users (e.g. education, training, software, database distribution, technical support, helpdesk). Among these services a web portal with links and access to locally developed and maintained software is essential and different for each node. Our web portal targets biomedical scientists in Switzerland and elsewhere, offering them access to a collection of important sequence analysis tools mirrored from other sites or developed locally. We describe here the Swiss EMBnet node web site (http://www.ch.embnet.org), which presents a number of original services not available anywhere else.

  20. Intraoperative Sentinel Lymph Node Evaluation

    DEFF Research Database (Denmark)

    Shaw, Richard; Christensen, Anders; Java, Kapil;

    2016-01-01

    BACKGROUND: Intraoperative analysis of sentinel lymph nodes would enhance the care of early-stage oral squamous cell carcinoma (OSCC). We determined the frequency and extent of cytokeratin 19 (CK19) expression in OSCC primary tumours and surrounding tissues to explore the feasibility of a "clinic......-ready" intraoperative diagnostic test (one step nucleic acid amplification-OSNA, sysmex). METHODS: Two cohorts were assembled: cohort 1, OSCC with stage and site that closely match cases suitable for sentinel lymph node biopsy (SLNB); cohort 2, HNSCC with sufficient fresh tumour tissue available for the OSNA assay (>50...

  1. Allocating resources between network nodes for providing a network node function

    NARCIS (Netherlands)

    Strijkers, R.J.; Meulenhoff, P.J.

    2014-01-01

    The invention provides a method wherein a first network node advertises available resources that a second network node may use to offload network node functions transparently to the first network node. Examples of the first network node are a client device (e.g. PC, notebook, tablet, smart phone), a

  2. Correlation of vascular endothelial growth factor C and chemokine receptor CCR7 with lymph node metastasis in bladder cancer%血管内皮生长因子C和趋化因子受体CCR7的表达与膀胱癌淋巴结转移之间的关系

    Institute of Scientific and Technical Information of China (English)

    黄启成; 李鑫磊; 杨树才; 孔建; 马晶

    2011-01-01

    Objective To investigate the effects of vascular endothelial growth factor (VEGF)-C and CCR7 in lymph node metastasis, the expression of VEGF-C and CCR7 was observed in bladder cancer. Methods Sixty paraffinembedded specimens from patients with bladder cancer were derided into lymph node metastasis group(n=36) and nonmetastasis group(n=24). The expressions of VEGF-C and CCR7 were detected by immunohistochemical stain and Western blot. Results VEGF-C and CCR7 proteins were expressed predominantly in the cytoplasm or/and membrane of the tumor cells, the expression of VEGF-C and CCR7 in lymph node metastasis group was significantly higher than that in nonmetastnsis group (P<0.05). The expressional rate of VEGF-C and CCR7 synergically was 61.1% and 33.3% in lymph node metastasis group and in nonmetastasis group respectively. Higher accuracy to predict lymph node metastasis was found in combined examination of VEGF-C and CCR7 expression with an area 0.708 under ROC curve. Conclusion VEGF-C and CCR7 indicated synergically role in promoting tumor lymph node metastasis, combined examination of VEGF-C and CCR7 might be beneficial for diagnosis of lymph node metastasis in bladder cancer.%目的 观察血管内皮生长因子(VEGF)-C和趋化因子受体CCR7在膀胱移行细胞癌组织内的表达情况,分析VEGF-C和CCR7表达与癌淋巴结转移之间的关系.方法 取膀胱癌病例60例,其中,淋巴结转移组36例,无淋巴结转移组24例.应用免疫组化法和Western blot技术观察VEGF-C和CCR7在膀胱癌组织内的表达.结果 VEGF-C和CCR7主要表达于膀胱癌细胞胞浆或,和胞膜内,二者在淋巴结转移组的表达率明显高于无淋巴结转移组.VEGF-C和CCR7蛋白同时表达在淋巴结转移组和非淋巴结转移组中的表达率分别为61.1%和33.3%,VEGF-C和CCR7的表达具有显著的相关性,联合检测VEGF-C和CCR7诊断膀胱癌淋巴结转移具有较高的准确度,ROC曲线下面积达0.708.结论 VEGF-C和CCR7

  3. Critical nodes in signalling pathways

    DEFF Research Database (Denmark)

    Taniguchi, Cullen M; Emanuelli, Brice; Kahn, C Ronald

    2006-01-01

    Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role...

  4. Node.js by example

    CERN Document Server

    Tsonev, Krasimir

    2015-01-01

    If you are a JavaScript developer with no experience with Node.js or server-side web development, this book is for you. It will lead you through creating a fairly complex social network. You will learn how to work with a database and create real-time communication channels.

  5. Model for the growth of the World Airline Network

    CERN Document Server

    Verma, T; Nagler, J; Andrade, J S; Herrmann, H J

    2016-01-01

    We propose a probabilistic growth model for transport networks which employs a balance between popularity of nodes and the physical distance between nodes. By comparing the degree of each node in the model network and the WAN, we observe that the difference between the two is minimized for $\\alpha\\approx 2$. Interestingly, this is the value obtained for the node-node correlation function in the WAN. This suggests that our model explains quite well the growth of airline networks.

  6. Lymph node staging in prostate cancer.

    Science.gov (United States)

    Sankineni, Sandeep; Brown, Anna M; Fascelli, Michele; Law, Yan Mee; Pinto, Peter A; Choyke, Peter L; Turkbey, Baris

    2015-05-01

    Nodal staging is important in prostate cancer treatment. While surgical lymph node dissection is the classic method of determining whether lymph nodes harbor malignancy, this is a very invasive technique. Current noninvasive approaches to identifying malignant lymph nodes are limited. Conventional imaging methods rely on size and morphology of lymph nodes and have notoriously low sensitivity for detecting malignant nodes. New imaging techniques such as targeted positron emission tomography (PET) imaging and magnetic resonance lymphography (MRL) with iron oxide particles are promising for nodal staging of prostate cancer. In this review, the strengths and limitations of imaging techniques for lymph node staging of prostate cancer are discussed.

  7. Controlling data transfers from an origin compute node to a target compute node

    Science.gov (United States)

    Archer, Charles J.; Blocksome, Michael A.; Ratterman, Joseph D.; Smith, Brian E.

    2011-06-21

    Methods, apparatus, and products are disclosed for controlling data transfers from an origin compute node to a target compute node that include: receiving, by an application messaging module on the target compute node, an indication of a data transfer from an origin compute node to the target compute node; and administering, by the application messaging module on the target compute node, the data transfer using one or more messaging primitives of a system messaging module in dependence upon the indication.

  8. Node Detection and Internode Length Estimation of Tomato Seedlings Based on Image Analysis and Machine Learning

    Directory of Open Access Journals (Sweden)

    Kyosuke Yamamoto

    2016-07-01

    Full Text Available Seedling vigor in tomatoes determines the quality and growth of fruits and total plant productivity. It is well known that the salient effects of environmental stresses appear on the internode length; the length between adjoining main stem node (henceforth called node. In this study, we develop a method for internode length estimation using image processing technology. The proposed method consists of three steps: node detection, node order estimation, and internode length estimation. This method has two main advantages: (i as it uses machine learning approaches for node detection, it does not require adjustment of threshold values even though seedlings are imaged under varying timings and lighting conditions with complex backgrounds; and (ii as it uses affinity propagation for node order estimation, it can be applied to seedlings with different numbers of nodes without prior provision of the node number as a parameter. Our node detection results show that the proposed method can detect 72% of the 358 nodes in time-series imaging of three seedlings (recall = 0.72, precision = 0.78. In particular, the application of a general object recognition approach, Bag of Visual Words (BoVWs, enabled the elimination of many false positives on leaves occurring in the image segmentation based on pixel color, significantly improving the precision. The internode length estimation results had a relative error of below 15.4%. These results demonstrate that our method has the ability to evaluate the vigor of tomato seedlings quickly and accurately.

  9. Decellularized Lymph Nodes as Scaffolds for Tissue Engineered Lymph Nodes

    Science.gov (United States)

    Cuzzone, Daniel A.; Albano, Nicholas J.; Aschen, Seth Z.; Ghanta, Swapna

    2015-01-01

    Abstract Background: The lymphatic system is commonly injured during cancer treatment. However, despite the morbidity of these injuries, there are currently no options for replacing damaged lymphatics. The purpose of this study was to optimize methods for decellularization of murine lymph nodes (LN) and to determine if these scaffolds can be used to tissue engineer lymph node-like structures. Methods and Results: LNs were harvested from adult mice and subjected to various decellularization protocols. The degree of decellularization and removal of nuclear material was analyzed histologically and quantitatively using DNA isolation. In addition, we analyzed histological architecture by staining for matrix proteins. After the optimal method of decellularization was identified, decellularized constructs were implanted in the renal capsule of syngeneic or allogeneic recipient mice and analyzed for antigenicity. Finally, to determine if decellularized constructs could deliver lymphocytes to recipient animals, the matrices were repopulated with splenocytes, implanted in submuscular pockets, and harvested 14 days later. Decellularization was best accomplished with the detergent sodium dodecyl sulfate (SDS), resulting in negligible residual cellular material but maintenance of LN architecture. Implantation of decellularized LNs into syngeneic or allogeneic mice did not elicit a significant antigenic response. In addition, repopulation of decellularized LNs with splenocytes resulted in successful in vivo cellular delivery. Conclusions: We show, for the first time, that LNs can be successfully decellularized and that these matrices have preserved extracellular matrix architecture and the potential to deliver leukocytes in vivo. Future studies are needed to determine if tissue engineered lymph nodes maintain immunologic function. PMID:25144673

  10. Intraoperative Sentinel Lymph Node Evaluation

    DEFF Research Database (Denmark)

    Shaw, Richard; Christensen, Anders; Java, Kapil

    2016-01-01

    BACKGROUND: Intraoperative analysis of sentinel lymph nodes would enhance the care of early-stage oral squamous cell carcinoma (OSCC). We determined the frequency and extent of cytokeratin 19 (CK19) expression in OSCC primary tumours and surrounding tissues to explore the feasibility of a "clinic...... mg). CK19 assays included qRT-PCR, RNA in situ hybridisation (ISH), and immunohistochemistry (IHC), as well as OSNA. RESULTS: CK19 mRNA expression was detected with variable sensitivity, depending on method, in 60-80% of primary OSCC tumours, while protein expression was observed in only 50......% of tumours. Discordance between different techniques indicated that OSNA was more sensitive than qRT-PCR or RNA-ISH, which in turn were more sensitive than IHC. OSNA results showed CK19 expression in 80% of primary cases, so if used for diagnosis of lymph node metastasis would lead to a false-negative result...

  11. Effect of CC chemokine receptor 7 and vascular endothelial growth factor-C expression on lymph node metastatic potentiality of non-small cell lung cancer%CC趋化因子受体7、血管内皮生长因子-C表达对非小细胞肺癌淋巴结转移潜能的影响

    Institute of Scientific and Technical Information of China (English)

    陈钢; 刘相燕; 王洲; 刘凡英

    2013-01-01

    目的 观察CC趋化因子受体7(CCR7)及血管内皮生长因子-C(VEGF-C)的表达对非小细胞肺癌(NSCLC)淋巴结转移潜能的影响.方法 临床收集行肺癌完全切除加系统淋巴结清扫的55例NSCLC患者的肺癌组织、淋巴结组织及正常肺组织标本.逆转录-聚合酶链反应(RT-PCR)检测CCR7及VEGF-C mRNA的表达;免疫组织化学检测CCR7及VEGF-C蛋白的表达.应用x2检验比较CCR7及VEGF-C表达差异,并应用Logistic回归分析判定肺癌淋巴结转移的独立相关因素.结果 肺癌组织中有39例(70.9%) CCR7 mRNA及32例(58.2%) VEGF-C mRNA表达阳性,有38例(69.1%) CCR7蛋白及29例(52.7%) VEGF-C蛋白表达阳性,且均与淋巴结转移密切相关(P<0.05).33例有转移的淋巴结中CCR7、VEGF-C mRNA的阳性表达率分别为84.8%、66.7%,分别明显高于无转移的淋巴结(27.3%、18.2%,P<0.05).Logistic多因素回归分析结果显示:肺癌组织中CCR7 mRNA的阳性表达[比值比(OR)=10.275,P<0.01]及VEGF-C mRNA的阳性表达(OR=5.550,P<0.05)是NSCLC患者淋巴结转移的独立危险因素.结论 CCR7及VEGF-C在NSCLC患者的肺癌组织及淋巴结转移灶中表达均明显增高,并与肺癌淋巴结转移密切相关;CCR7及VEGF-C的表达可能促进了NSCLC淋巴结转移.%Objective To explore the effects of CC chemokine receptor 7 (CCR7) and vascular endothelial growth factor-C (VEGF-C) expression on lymph node metastatic potentiality of non-small cell lung cancer (NSCLC).Methods The samples of cancer tissues,lymph nodes and normal lung tissues from 55 patients with NSCLC who underwent complete resection were examined by using reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry to detect CCR7 and VEGF-C expression.The difference in the CCR7 and VEGF-C expression was compared by x2 test.Logistic regression analysis was performed to determine the independent risk factors of lymph node metastasis of NSCLC.Re sults In

  12. Axillary Lymph Nodes and Breast Cancer

    Science.gov (United States)

    ... more likely to affect arm function and cause lymphedema. For this reason, sentinel node biopsy is the ... OR supraclavicular (above the clavicle) nodes have cancer Lymphedema Lymphedema [lim-fa-DEE-ma] is a build- ...

  13. Interpectoral Nodes Metastases in Breast Cancer

    Institute of Scientific and Technical Information of China (English)

    ZHOU Xin; YANG Jia-xiang; LIU Xiao-yu; ZHU Ning-sheng; JIANG Ge-li

    2008-01-01

    Objective:To study interpectoral nodes metastasis rate in breast cancer and its clinical significance.Methods:171 female patients undergone surgery for breast cancer were reviewed,of whom the interpectoral nodes were SUbjected to pathological examination.Results:Interpectoral nodes were identified in 25.7% of the 171 female patients,and the interpectoral nodes metastasis rate was 9.9%.The patients with interpectoral nodes metastasis had larger tumor size,later TNM classification,higher axillary apical nodes metastasis rate and lower ER positive rate.Conclusion:Dissection of interpectoral nodes should be regard as routine clinical practice in modified radical mastectomy,and interpectoral nodes should be snbjected to pathological examination.

  14. Underwater Sensor Nodes and Networks

    Directory of Open Access Journals (Sweden)

    Jaime Lloret

    2013-09-01

    Full Text Available Sensor technology has matured enough to be used in any type of environment. The appearance of new physical sensors has increased the range of environmental parameters for gathering data. Because of the huge amount of unexploited resources in the ocean environment, there is a need of new research in the field of sensors and sensor networks. This special issue is focused on collecting recent advances on underwater sensors and underwater sensor networks in order to measure, monitor, surveillance of and control of underwater environments. On the one hand, from the sensor node perspective, we will see works related with the deployment of physical sensors, development of sensor nodes and transceivers for sensor nodes, sensor measurement analysis and several issues such as layer 1 and 2 protocols for underwater communication and sensor localization and positioning systems. On the other hand, from the sensor network perspective, we will see several architectures and protocols for underwater environments and analysis concerning sensor network measurements. Both sides will provide us a complete view of last scientific advances in this research field.

  15. The application of sentinel lymph node detection in thyroid cancer%前哨淋巴结检测在甲状腺癌中的应用

    Institute of Scientific and Technical Information of China (English)

    蔡蕾; 华清泉

    2013-01-01

    Thyroid cancer is more common in thyroid diseases, because of its slow growth and good prognosis, different scholars have different views on lymph node dissection. During the study of definition and positioning methods of sentinel lymph node biopsy, discuss the necessity of cervical node dissection and the application of cleaning scope in thyroid cancer surgery.

  16. Nonadiabatic eigenfunctions can have conical nodes

    Science.gov (United States)

    Foster, Peter W.; Peters, William K.; Jonas, David M.

    2017-09-01

    It has been argued the total vibrational probability amplitude for a molecular nonadiabatic eigenfunction should not have nodes unless required by symmetry. For a model with two nonadiabatically coupled electronic states, exact factorization of nonadiabatic eigenfunctions into a total vibrational probability amplitude and a normalized electronic factor reveals zero-dimensional nodes in nonadiabatic eigenfunctions over a two-dimensional vibrational space. These conical nodes have the shape of a right elliptical cone with the node at the vertex. Low dimensionality nodes are likely when the number of nonadiabatically coupled electronic states is less than or equal to the dimensionality of the vibrational space.

  17. Characteristics of cast and welded aluminium nodes

    Energy Technology Data Exchange (ETDEWEB)

    Oedegaard, J.; Polanco, M.; Syvertsen, F.; Sund, H. [SINTEF, Trondheim (Norway). Materials Technology

    2000-07-01

    It has been demonstrated that sand cast aluminium nodes can be produced with properties that gives competitive energy absorption capacity compared with welded aluminium nodes. Sand cast nodes could be mass-produced to a low cost and with properties that should be competitive to the properties of fusion welded nodes. This may open for simpler and more cost-effective joint alternatives when production of aluminium space-frames and subassemblies are in focus. Cast nodes joined to extruded members by adhesive bonding could be one example. (orig.)

  18. A tattoo pigmented node and breast cancer.

    Science.gov (United States)

    Soran, A; Kanbour-Shakir, A; Bas, O; Bonaventura, M

    2014-01-01

    Over the last decade, the axillary SLNB has replaced routine ALND for clinical staging in early breast cancer. Studies describe a potential pitfall in the identification of a true sentinel node during surgery due to lymph node pigmentation secondary to migration of tattoo dye. These pigmented “pseudo-sentinel” nodes, if located superficially in the axilla, may mimic the blue sentinel node on visual inspection, therefore missing the true sentinel node and potentially understaging the patient. Here, we present a case report of a breast cancer patient with a tattoo and discuss the importance of tattoo pigment in the LN (Fig. 1, Ref. 8).

  19. Incidental Suspicious Regional Lymph Nodes on Breast Sonography: Is Sampling Necessary?

    Science.gov (United States)

    Raj, Sean D; Amer, Ahmed M; Garg, Naveen; Krishnamurthy, Savitri; Hess, Kenneth R; Park, Young Mi; Moseley, Tanya; Whitman, Gary J

    Suspicious regional lymph nodes may be incidentally identified on breast ultrasound examinations in patients who present for sonographic evaluation without a known or a suspected breast malignancy, and there is a paucity of data on whether biopsy should be performed. This study aims to characterize incidental sonographically detected suspicious regional lymph nodes and determine whether tissue sampling or follow-up imaging is required. A total of 40,773 consecutive breast ultrasounds were reviewed. Overall, 7 women with nonpalpable, incidental, suspicious axillary or supraclavicular lymph nodes in an otherwise unremarkable breast and without history of malignancy or systemic disease were identified. In all, 5 women with 6 nodes underwent ultrasound-guided fine needle aspiration and 2 women with 3 nodes were recommended follow-up ultrasound. Follow-up imaging, cytology, and all-cause clinical data were reviewed to evaluate outcomes. All 6 biopsied lymph nodes (mean = 1.5cm) were benign on cytology. Follow-up imaging was available for 3 nodes (mean = 2.6 years), with all-cause follow-up for all nodes of 2.2 years. In the follow-up group, 3 lymph nodes (mean = 1.6cm) were monitored (mean = 4.3 years) with all-cause follow-up of 4.7 years. No new cancers, growth, or suspicious features were found in these nodes during follow-up for either group of women. In conclusion, women without history of prior malignancy or systemic disease with incidentally detected, nonpalpable, suspicious regional lymph nodes with an otherwise normal breast ultrasound examination underwent fine needle aspiration or were recommended short-term follow-up ultrasound. No indeterminate features or malignancies were observed at the time of tissue sampling or developed over several years of follow-up. Avoiding sampling of these nodes would reduce patient morbidity and health care costs. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. The mouse lymph node as an ectopic transplantation site for multiple tissues.

    Science.gov (United States)

    Komori, Junji; Boone, Lindsey; DeWard, Aaron; Hoppo, Toshitaka; Lagasse, Eric

    2012-10-01

    Cell-based therapy has been viewed as a promising alternative to organ transplantation, but cell transplantation aimed at organ repair is not always possible. Here we show that the mouse lymph node can support the engraftment and growth of healthy cells from multiple tissues. Direct injection of hepatocytes into a single mouse lymph node generated enough ectopic liver mass to rescue the survival of mice with lethal metabolic disease. Furthermore, thymuses transplanted into single lymph nodes of athymic nude mice generated functional immune systems that were capable of rejecting allogeneic and xenogeneic grafts. Additionally, pancreatic islets injected into the lymph nodes of diabetic mice restored normal glucose control. Collectively, these results suggest the practical approach of targeting lymph nodes to restore, maintain or improve tissue and organ functions.

  1. Node Deployment and the Impact of Relay Nodes in Wireless Sensor Network

    Directory of Open Access Journals (Sweden)

    Rudranath Mitra

    2012-06-01

    Full Text Available Node deployment is a fundamental issue to be solved in wireless sensor network. A proper node deployment can reduce the complexity of problems in WSN as for eg, routing, data fusion, communication etc. Different node deployment models have been proposed to reduce the complexity. In this paper we will discuss about the three models- Tri-hexagon-tiling (THT, Uniform Random and Square Grid. The nature of deployment of sensor nodes depend on the type of sensors, application and the environment where the networks will operate. Deployment of sensor nodes can be random or pre-determined. In random deployment nodes are deployed in a random manner. In pre-determined deployment, location of the nodes are specified. Most commonly used cell structure is Regular Hexagonal Cell Architecture. Here we will discuss the concept of relay nodes and its impact in sensor nodes

  2. Localizing and placement of network node functions in a network

    NARCIS (Netherlands)

    Strijkers, R.J.; Meulenhoff, P.J.

    2014-01-01

    The invention enables placement and use of a network node function in a second network node instead of using the network node function in a first network node. The network node function is e.g. a server function or a router function. The second network node is typically located in or close to the cl

  3. Localizing and placement of network node functions in a network

    NARCIS (Netherlands)

    Strijkers, R.J.; Meulenhoff, P.J.

    2014-01-01

    The invention enables placement and use of a network node function in a second network node instead of using the network node function in a first network node. The network node function is e.g. a server function or a router function. The second network node is typically located in or close to the

  4. Node Exchange Network and its Statistical Analysis

    CERN Document Server

    Toyota, N

    2005-01-01

    In considering a social network, there are cases where people is transferred to another place. Then the physical (direct) relations among nodes are lost by the movement. In terms of a network theory, some nodes break the present connections with neighboring nodes, move and there build new connections of nodes. For simplicity we here consider only that two nodes exchange the place each other on a network. Such exchange is assumed to be constantly carried out. We study this dynamic network (node exchange network NEN) and uncover some new features which usual networks do not contain. We mainly consider average path length and the diameter. Lastly we consider a propagation of one virus on the network by a computer simulation. They are compared to other networks investigated hitherto. The relation to a scale free network is also discussed.

  5. Node for Front-End Developers

    CERN Document Server

    Means, Garann

    2012-01-01

    If you know how to use JavaScript in the browser, you already have the skills you need to put JavaScript to work on back-end servers with Node. This hands-on book shows you how to use this popular JavaScript platform to create simple server applications, communicate with the client, build dynamic pages, work with data, and tackle other tasks. Although Node has a complete library of developer-contributed modules to automate server-side development, this book will show you how to program with Node on your own, so you truly understand the platform. Discover firsthand how well Node works as a we

  6. A New Scheme for Minimizing Malicious Behavior of Mobile Nodes in Mobile Ad Hoc Networks

    CERN Document Server

    Rizvi, Syed S

    2009-01-01

    The performance of Mobile Ad hoc networks (MANET) depends on the cooperation of all active nodes. However, supporting a MANET is a cost-intensive activity for a mobile node. From a single mobile node perspective, the detection of routes as well as forwarding packets consume local CPU time, memory, network-bandwidth, and last but not least energy. We believe that this is one of the main factors that strongly motivate a mobile node to deny packet forwarding for others, while at the same time use their services to deliver its own data. This behavior of an independent mobile node is commonly known as misbehaving or selfishness. A vast amount of research has already been done for minimizing malicious behavior of mobile nodes. However, most of them focused on the methods/techniques/algorithms to remove such nodes from the MANET. We believe that the frequent elimination of such miss-behaving nodes never allowed a free and faster growth of MANET. This paper provides a critical analysis of the recent research wok and ...

  7. Sentinel Node Biopsy Alone versus Completion Axillary Node Dissection in Node Positive Breast Cancer: Systematic Review and Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Rachna Ram

    2014-01-01

    Full Text Available Introduction. There has been recent interest in validity of completion axillary node dissection after a positive sentinel node. This systematic review aims to ascertain if sentinel lymph node dissection alone was noninferior to axillary lymph node dissection for breast cancer patients who have a positive sentinel node. Method. A systematic review of the electronic databases Embase, MEDLINE, and Cochrane Register of Controlled Trials was carried out. Only randomised trials that had patients with positive sentinel node as the study sample were included in the meta-analysis using the reported hazard ratios with a fixed effect model. Results. Three randomised controlled trials and five retrospective studies were identified. The pooled effect for overall survival was HR 0.94, 95% CI [0.79, 1.19], and for disease free survival was HR 0.83, 95% CI [0.60, 1.14]. The reported rates for locoregional recurrence were similar in both groups. The surgical morbidity was found to be significantly more in patients who had underwent axillary dissection. Conclusion. Amongst patients with micrometastasis in the sentinel node, no further axillary dissection is necessary. For patients with macrometastasis in the sentinel node, it is reasonable to consider omitting axillary dissection to avoid the morbidity of the procedure.

  8. Sentinel Node Biopsy Alone versus Completion Axillary Node Dissection in Node Positive Breast Cancer: Systematic Review and Meta-Analysis

    Science.gov (United States)

    Singh, Jasprit; McCaig, Eddie

    2014-01-01

    Introduction. There has been recent interest in validity of completion axillary node dissection after a positive sentinel node. This systematic review aims to ascertain if sentinel lymph node dissection alone was noninferior to axillary lymph node dissection for breast cancer patients who have a positive sentinel node. Method. A systematic review of the electronic databases Embase, MEDLINE, and Cochrane Register of Controlled Trials was carried out. Only randomised trials that had patients with positive sentinel node as the study sample were included in the meta-analysis using the reported hazard ratios with a fixed effect model. Results. Three randomised controlled trials and five retrospective studies were identified. The pooled effect for overall survival was HR 0.94, 95% CI [0.79, 1.19], and for disease free survival was HR 0.83, 95% CI [0.60, 1.14]. The reported rates for locoregional recurrence were similar in both groups. The surgical morbidity was found to be significantly more in patients who had underwent axillary dissection. Conclusion. Amongst patients with micrometastasis in the sentinel node, no further axillary dissection is necessary. For patients with macrometastasis in the sentinel node, it is reasonable to consider omitting axillary dissection to avoid the morbidity of the procedure. PMID:25383226

  9. Penile Cancer: Contemporary Lymph Node Management.

    Science.gov (United States)

    O'Brien, Jonathan S; Perera, Marlon; Manning, Todd; Bozin, Mike; Cabarkapa, Sonja; Chen, Emily; Lawrentschuk, Nathan

    2017-06-01

    In penile cancer, the optimal diagnostics and management of metastatic lymph nodes are not clear. Advances in minimally invasive staging, including dynamic sentinel lymph node biopsy, have widened the diagnostic repertoire of the urologist. We aimed to provide an objective update of the recent trends in the management of penile squamous cell carcinoma, and inguinal and pelvic lymph node metastases. We systematically reviewed several medical databases, including the Web of Science® (with MEDLINE®), Embase® and Cochrane databases, according to PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses) guidelines. The search terms used were penile cancer, lymph node, sentinel node, minimally invasive, surgery and outcomes, alone and in combination. Articles pertaining to the management of lymph nodes in penile cancer were reviewed, including original research, reviews and clinical guidelines published between 1980 and 2016. Accurate and minimally invasive lymph node staging is of the utmost importance in the surgical management of penile squamous cell carcinoma. In patients with clinically node negative disease, a growing body of evidence supports the use of sentinel lymph node biopsies. Dynamic sentinel lymph node biopsy exposes the patient to minimal risk, and results in superior sensitivity and specificity profiles compared to alternate nodal staging techniques. In the presence of locoregional disease, improvements in inguinal or pelvic lymphadenectomy have reduced morbidity and improved oncologic outcomes. A multimodal approach of chemotherapy and surgery has demonstrated a survival benefit for patients with advanced disease. Recent developments in lymph node management have occurred in penile cancer, such as minimally invasive lymph node diagnosis and intervention strategies. These advances have been met with a degree of controversy in the contemporary literature. Current data suggest that dynamic sentinel lymph node biopsy provides excellent

  10. Coupling effect of nodes popularity and similarity on social network persistence

    Science.gov (United States)

    Jin, Xiaogang; Jin, Cheng; Huang, Jiaxuan; Min, Yong

    2017-02-01

    Network robustness represents the ability of networks to withstand failures and perturbations. In social networks, maintenance of individual activities, also called persistence, is significant towards understanding robustness. Previous works usually consider persistence on pre-generated network structures; while in social networks, the network structure is growing with the cascading inactivity of existed individuals. Here, we address this challenge through analysis for nodes under a coevolution model, which characterizes individual activity changes under three network growth modes: following the descending order of nodes’ popularity, similarity or uniform random. We show that when nodes possess high spontaneous activities, a popularity-first growth mode obtains highly persistent networks; otherwise, with low spontaneous activities, a similarity-first mode does better. Moreover, a compound growth mode, with the consecutive joining of similar nodes in a short period and mixing a few high popularity nodes, obtains the highest persistence. Therefore, nodes similarity is essential for persistent social networks, while properly coupling popularity with similarity further optimizes the persistence. This demonstrates the evolution of nodes activity not only depends on network topology, but also their connective typology.

  11. Salvage Lymph Node Dissection for Node-only Recurrence of Prostate Cancer: Ready for Prime Time?

    Science.gov (United States)

    Suardi, Nazareno; Briganti, Alberto; Gandaglia, Giorgio; Fossati, Nicola; Montorsi, Francesco

    2016-12-30

    Several studies show that salvage lymph-node dissection for node-only recurrence of prostate cancer after radical treatment might represent a viable treatment modality for node-only recurrent PCa. However, as long as high quality data is not available, this approach should still be considered experimental.

  12. Role of dynamic sentinel node biopsy in carcinoma penis with or without palpable nodes

    Directory of Open Access Journals (Sweden)

    N Kathiresan

    2016-01-01

    Conclusion: DSLNB is a useful and reliable technique to identify the involved node(s in patients diagnosed as having carcinoma penis with clinical N0 status (with or without palpable nodes. It helps to avoid the morbidity associated with a staging inguinal dissection in these patients.

  13. Contrast enhanced ultrasound of sentinel lymph nodes

    Directory of Open Access Journals (Sweden)

    XinWu Cui

    2013-03-01

    Full Text Available Sentinel lymph nodes are the first lymph nodes in the region that receive lymphatic drainage from a primary tumor. The detection or exclusion of sentinel lymph node micrometastases is critical in the staging of cancer, especially breast cancer and melanoma because it directly affects patient’s prognosis and surgical management. Currently, intraoperative sentinel lymph node biopsies using blue dye and radioisotopes are the method of choice for the detection of sentinel lymph node with high identification rate. In contrast, conventional ultrasound is not capable of detecting sentinel lymph nodes in most cases. Contrast enhanced ultrasound with contrast specific imaging modes has been used for the evaluation and diagnostic work-up of peripherally located suspected lymphadenopathy. The method allows for real-time analysis of all vascular phases and the visualization of intranodal focal “avascular” areas that represent necrosis or deposits of neoplastic cells. In recent years, a number of animal and human studies showed that contrast enhanced ultrasound can be also used for the detection of sentinel lymph node, and may become a potential application in clinical routine. Several contrast agents have been used in those studies, including albumin solution, hydroxyethylated starch, SonoVue®, Sonazoid® and Definity®. This review summarizes the current knowledge about the use of ultrasound techniques in detection and evaluation of sentinel lymph node.

  14. Towards Interactive, Incremental Programming of ROS Nodes

    DEFF Research Database (Denmark)

    Adam, Marian Sorin; Schultz, Ulrik Pagh

    experimentation. We propose the use of an internal DSL providing both a tool to interactively create ROS nodes and a behaviour-replacement mechanism to interactively reshape existing ROS nodes by wrapping the external interfaces (the publish/subscribe topics), dynamically controlled using the Python command line...

  15. A multiple node software development environment

    Energy Technology Data Exchange (ETDEWEB)

    Heinicke, P.; Nicinski, T.; Constanta-Fanourakis, P.; Petravick, D.; Pordes, R.; Ritchie, D.; White, V.

    1987-06-01

    Experimenters on over 30 DECnet nodes at Fermilab use software developed, distributed, and maintained by the Data Acquisition Software Group. A general methodology and set of tools have been developed to distribute, use and manage the software on different sites. The methodology and tools are of interest to any group developing and using software on multiple nodes.

  16. A node architecture for disaster relief networking

    NARCIS (Netherlands)

    Hoeksema, F.W.; Heskamp, M.; Schiphorst, R.; Slump, C.H.

    2005-01-01

    In this paper we present node architecture for a personal node in a cognitive ad-hoc disaster relief network. This architecture is motivated from the network system requirements, especially single-hop distance and jamming-resilience requirements. It is shown that the power consumption of current-day

  17. Testnodes: a Lightweight Node-Testing Infrastructure

    Science.gov (United States)

    Fay, R.; Bland, J.

    2014-06-01

    A key aspect of ensuring optimum cluster reliability and productivity lies in keeping worker nodes in a healthy state. Testnodes is a lightweight node testing solution developed at Liverpool. While Nagios has been used locally for general monitoring of hosts and services, Testnodes is optimised to answer one question: is there any reason this node should not be accepting jobs? This tight focus enables Testnodes to inspect nodes frequently with minimal impact and provide a comprehensive and easily extended check with each inspection. On the server side, Testnodes, implemented in python, interoperates with the Torque batch server to control the nodes production status. Testnodes remotely and in parallel executes client-side test scripts and processes the return codes and output, adjusting the node's online/offline status accordingly to preserve the integrity of the overall batch system. Testnodes reports via log, email and Nagios, allowing a quick overview of node status to be reviewed and specific node issues to be identified and resolved quickly. This presentation will cover testnodes design and implementation, together with the results of its use in production at Liverpool, and future development plans.

  18. Localized Lymph Node Light Chain Amyloidosis

    Directory of Open Access Journals (Sweden)

    Binod Dhakal

    2015-01-01

    Full Text Available Immunoglobulin-derived light chain amyloidosis can occasionally be associated with localized disease. We present a patient with localized lymph node light chain amyloidosis without an underlying monoclonal protein or lymphoproliferative disorder and review the literature of lymph node amyloidosis discussing work-up and risk factors for systemic progression.

  19. Extended lymph node dissection for prostate cancer.

    Science.gov (United States)

    Jeschke, Stephan; Burkhard, Fiona C; Thurairaja, Ramesh; Dhar, Nivedita; Studer, Urs E

    2008-05-01

    Lymph node status is an important determinant for the management of patients with newly diagnosed prostate cancer. Given the significant limitations of cross-sectional and functional preoperative imaging in the detection of small metastases, pelvic lymph node dissection remains the only reliable staging method in clinically localized prostate cancer. Although lymph node dissection is a well-established form of staging in prostate cancer, controversy remains about indications and the surgical extent of the procedure. Reported practices vary from omitting pelvic lymph node dissection in low-risk disease to routine pelvic lymph node dissection in all radical prostatectomy patients. This review highlights the recent literature concerning pelvic lymphadenectomy in prostate cancer with respect to anatomical extent and oncologic outcome.

  20. Locating influential nodes in complex networks

    Science.gov (United States)

    Malliaros, Fragkiskos D.; Rossi, Maria-Evgenia G.; Vazirgiannis, Michalis

    2016-01-01

    Understanding and controlling spreading processes in networks is an important topic with many diverse applications, including information dissemination, disease propagation and viral marketing. It is of crucial importance to identify which entities act as influential spreaders that can propagate information to a large portion of the network, in order to ensure efficient information diffusion, optimize available resources or even control the spreading. In this work, we capitalize on the properties of the K-truss decomposition, a triangle-based extension of the core decomposition of graphs, to locate individual influential nodes. Our analysis on real networks indicates that the nodes belonging to the maximal K-truss subgraph show better spreading behavior compared to previously used importance criteria, including node degree and k-core index, leading to faster and wider epidemic spreading. We further show that nodes belonging to such dense subgraphs, dominate the small set of nodes that achieve the optimal spreading in the network.

  1. [The Role of Supraclavicular lymph node dissection in Breast Cancer Patients with Synchronous Ipsilateral Supraclavicular Lymph Node Metastasis].

    Science.gov (United States)

    Zhang, W; Qi, X M; Chen, A X; Zhang, P; Cao, X C; Xiao, C H

    2017-05-23

    recurrence-free survival rates of human epidermal growth factor receptor 2 (HER2)-positive patients were 61.2% and 48.0%(P=0.634), respectively, and the 5-year overall survival rates were 37.2% and 65.4%(P=0.032). Forty-seven patients suffered distant metastases and the 5-year metastases free survival rates were 37.3% and 38.5% in supraclavicular lymph node dissection group and control group, respectively. Conclusion: Supraclavicular lymph node dissection maybe an effective approach to improve the loco-regional control for the patients with ISLM, especially for ER negative and PR negative subtypes, but it might has adverseeffects for the patients with negative HER2 status.

  2. Defining nodes in complex brain networks

    Directory of Open Access Journals (Sweden)

    Matthew Lawrence Stanley

    2013-11-01

    Full Text Available Network science holds great promise for expanding our understanding of the human brain in health, disease, development, and aging. Network analyses are quickly becoming the method of choice for analyzing functional MRI data. However, many technical issues have yet to be confronted in order to optimize results. One particular issue that remains controversial in functional brain network analyses is the definition of a network node. In functional brain networks a node represents some predefined collection of brain tissue, and an edge measures the functional connectivity between pairs of nodes. The characteristics of a node, chosen by the researcher, vary considerably in the literature. This manuscript reviews the current state of the art based on published manuscripts and highlights the strengths and weaknesses of three main methods for defining nodes. Voxel-wise networks are constructed by assigning a node to each, equally sized brain area (voxel. The fMRI time-series recorded from each voxel is then used to create the functional network. Anatomical methods utilize atlases to define the nodes based on brain structure. The fMRI time-series from all voxels within the anatomical area are averaged and subsequently used to generate the network. Functional activation methods rely on data from traditional fMRI activation studies, often from databases, to identify network nodes. Such methods identify the peaks or centers of mass from activation maps to determine the location of the nodes. Small (~10-20 millimeter diameter spheres located at the coordinates of the activation foci are then applied to the data being used in the network analysis. The fMRI time-series from all voxels in the sphere are then averaged, and the resultant time series is used to generate the network. We attempt to clarify the discussion and move the study of complex brain networks forward. While the correct method to be used remains an open, possibly unsolvable question that

  3. Joint estimation of preferential attachment and node fitness in growing complex networks

    Science.gov (United States)

    Pham, Thong; Sheridan, Paul; Shimodaira, Hidetoshi

    2016-09-01

    Complex network growth across diverse fields of science is hypothesized to be driven in the main by a combination of preferential attachment and node fitness processes. For measuring the respective influences of these processes, previous approaches make strong and untested assumptions on the functional forms of either the preferential attachment function or fitness function or both. We introduce a Bayesian statistical method called PAFit to estimate preferential attachment and node fitness without imposing such functional constraints that works by maximizing a log-likelihood function with suitably added regularization terms. We use PAFit to investigate the interplay between preferential attachment and node fitness processes in a Facebook wall-post network. While we uncover evidence for both preferential attachment and node fitness, thus validating the hypothesis that these processes together drive complex network evolution, we also find that node fitness plays the bigger role in determining the degree of a node. This is the first validation of its kind on real-world network data. But surprisingly the rate of preferential attachment is found to deviate from the conventional log-linear form when node fitness is taken into account. The proposed method is implemented in the R package PAFit.

  4. Joint estimation of preferential attachment and node fitness in growing complex networks.

    Science.gov (United States)

    Pham, Thong; Sheridan, Paul; Shimodaira, Hidetoshi

    2016-09-07

    Complex network growth across diverse fields of science is hypothesized to be driven in the main by a combination of preferential attachment and node fitness processes. For measuring the respective influences of these processes, previous approaches make strong and untested assumptions on the functional forms of either the preferential attachment function or fitness function or both. We introduce a Bayesian statistical method called PAFit to estimate preferential attachment and node fitness without imposing such functional constraints that works by maximizing a log-likelihood function with suitably added regularization terms. We use PAFit to investigate the interplay between preferential attachment and node fitness processes in a Facebook wall-post network. While we uncover evidence for both preferential attachment and node fitness, thus validating the hypothesis that these processes together drive complex network evolution, we also find that node fitness plays the bigger role in determining the degree of a node. This is the first validation of its kind on real-world network data. But surprisingly the rate of preferential attachment is found to deviate from the conventional log-linear form when node fitness is taken into account. The proposed method is implemented in the R package PAFit.

  5. Relationship between Lymphatic Vessel Density and Lymph Node Metastasis of Invasive Micropapillary Carcinoma of the Breast

    Institute of Scientific and Technical Information of China (English)

    Xiaojing Guo; Ling Chen; Ronggang Lang; Yu Fan; Li Fu

    2006-01-01

    OBJECTIVE To investigate the relationship between lymphatic vessel density and lymph node metastasis of invasive micropapillary carcinoma (IMPC) of the breast.METHODS The immunohistochemical study for vascular endothelial growth factor-c (VEGF-C), VEGF Receptor-3 (VEGFR-3) and lymphatic vessel density of 51 cases of IMPC were performed, and lymph node metastases were examined by microscopic analysis of these cases.RESULTS In IMPC, VEGF-C was expressed in the cytoplasm and/or on the membrane of the tumor cells, and the expression of VEGF-C showed a positive correlation with lymph node metastasis (P<0.01). Lymphatic vessel density was determined by the number of micro-lymphatic vessels with VEGFR-3 positive staining. Lymphatic vessel density was positively correlated with VEGF-C expression (P<0.01) and lymph node metastasis (P<0.01). The percentage of IMPC in the tumor was not associated with the incidence of lymph node metastasis. The metastatic foci in lymph nodes were either pure or predominant micropapillary carcinoma.CONCLUSION The results suggested that VEGF-C overexpression stimulated tumor lymphangiogenesis, and the increased lymphatic vessel density may be the key factor that influenced lymph node metastasis of IMPC.

  6. Pattern of lymph node metastases of squamous cell esophageal cancer based on the anatomical lymphatic drainage system: efficacy of lymph node dissection according to tumor location

    Science.gov (United States)

    2017-01-01

    Knowing the anatomical lymphatic drainage of the esophagus is crucial to understanding the dissemination pattern of esophageal tumor. During the embryonal growth, the middle and lower part of the esophagus stretches as the lymphatic networks develop in the submucosal layer. The abundant submucosal lymphatics drain in a longitudinal fashion directly to their proximal and distal ends. The lymphatic route from the proximal esophagus through recurrent nerve nodes to supraclavicular nodes are a component of the mesentery of the proximal esophagus. The lower esophagus mostly drains its lymph into paracardial nodes related to celiac nodes through the mesentery of the distal esophagus. Lymphatic routes to mid and lower paraesophageal nodes usually originate from the intermuscular area of the muscularis propria. The lymphatic communication between the submucosa and intermuscular area is limited. The anatomical concept was confirmed clinically by a large series of single institution and the nationwide registry in Japan. The clinical data for the incidence of involved nodes verified the anatomical observations that long longitudinal extension of lymphatic drainage in the submucosa connected to the upper mediastinum lymphatics and paracardial lymphatics. The extent of dissection should be not tailored according to the anatomical distance from the tumor but according to the incidences of metastasis of each area, those were differed by tumor location. The areas for node dissection should be modified according to the tumor location. Although in patients with tumor limited to within the submucosal layer, even with tumors located in the mid- and lower esophagus, lymphatic metastasis was frequent in the upper mediastinum and perigastric area via the abundant submucosal lymphatics in a longitudinal fashion. When tumor invades or penetrates the muscle layer, the incidence of paraesophageal lymph node metastasis in the middle and lower mediastinum increases. PMID:28815068

  7. Checkpointing for a hybrid computing node

    Energy Technology Data Exchange (ETDEWEB)

    Cher, Chen-Yong

    2016-03-08

    According to an aspect, a method for checkpointing in a hybrid computing node includes executing a task in a processing accelerator of the hybrid computing node. A checkpoint is created in a local memory of the processing accelerator. The checkpoint includes state data to restart execution of the task in the processing accelerator upon a restart operation. Execution of the task is resumed in the processing accelerator after creating the checkpoint. The state data of the checkpoint are transferred from the processing accelerator to a main processor of the hybrid computing node while the processing accelerator is executing the task.

  8. Lymph node involvement in multicystic peritoneal mesothelioma.

    Science.gov (United States)

    Engohan-Aloghe, Corinne; Anaf, Vincent; Noël, Jean Christophe

    2009-11-01

    Multicystic peritoneal mesothelioma is an uncommon lesion most frequently encountered in women of reproductive age. Although the pathologic characteristics have been documented, the lymph node status associated with this pathology, the etiopathogenesis and prognosis of which remain unclear, is unknown. We report here the case of a 35-year-old woman with a 5.5 cm multicystic mesothelioma affecting the pelvic peritoneum of the rectum. Involvement by multicystic mesothelioma was observed within two lymph nodes simultaneously resected with the tumor. To the best of our knowledge, lymph node involvement has not been described in previous studies.

  9. Inguinal Lymph Node Anthracosis: A Case Report

    Science.gov (United States)

    Soto, Carlos Alberto

    2016-01-01

    Summary: Anthracosis is defined as black, dense pigments in tissues, usually carbon deposits. We, as surgeons, have to make decisions during surgery to the best of our knowledge and based on what the literature provides us. We present the case of a 30-year-old female patient who underwent abdominoplasty. During surgery, bilateral inguinal pigmented and enlarged lymph nodes were seen. Biopsy of the nodes was done to rule out any malignancy. The results showed tattoo pigments on all lymph nodes. We present this case as tattoo pigment migration, which has been rarely described. PMID:27536493

  10. Macroscopic description of complex adaptive networks co-evolving with dynamic node states

    CERN Document Server

    Wiedermann, Marc; Heitzig, Jobst; Lucht, Wolfgang; Kurths, Jürgen

    2015-01-01

    In many real-world complex systems, the time-evolution of the network's structure and the dynamic state of its nodes are closely entangled. Here, we study opinion formation and imitation on an adaptive complex network which is dependent on the individual dynamic state of each node and vice versa to model the co-evolution of renewable resources with the dynamics of harvesting agents on a social network. The adaptive voter model is coupled to a set of identical logistic growth models and we show that in such systems, the rate of interactions between nodes as well as the adaptive rewiring probability play a crucial role for the sustainability of the system's equilibrium state. We derive a macroscopic description of the system which provides a general framework to model and quantify the influence of single node dynamics on the macroscopic state of the network and is applicable to many fields of study, such as epidemic spreading or social modeling.

  11. Self-adaptive formation of uneven node spacings in wild bamboo

    Science.gov (United States)

    Shima, Hiroyuki; Sato, Motohiro; Inoue, Akio

    2016-02-01

    Bamboo has a distinctive structure wherein a long cavity inside a cylindrical woody section is divided into many chambers by stiff diaphragms. The diaphragms are inserted at nodes and thought to serve as ring stiffeners for bamboo culms against the external load; if this is the case, the separation between adjacent nodes should be configured optimally in order to enhance the mechanical stability of the culms. Here, we reveal the hitherto unknown blueprint of the optimal node spacings used in the growth of wild bamboo. Measurement data analysis together with theoretical formulations suggest that wild bamboos effectively control their node spacings as well as other geometric parameters in accord with the lightweight and high-strength design concept.

  12. Node discovery in meta-population network behind infectious disease outbreak

    CERN Document Server

    Maeno, Yoshiharu

    2010-01-01

    Stochasticity and spatial heterogeneity are of great interest recently in studying the spread of an infectious disease. Populations in a combination of epidemiological compartment models and a meta-population network model are described by stochastic differential equations. The presented method solves a node discovery problem to identify the nodes within a given dataset which are directly influenced by an unknown neighboring node during the spread. The dataset is either the time sequence data on the number of infectious persons or new cases in the early growth phase of an infectious disease outbreak. The network topology and transmission parameters are revealed by the maximal likelihood estimation. The degree of influence on individual nodes from an unknown origin is calculated with the technique of the extreme sequence detection given the revealed topology and parameters. The method is tested with computationally synthesized datasets and the WHO dataset on SARS outbreak.

  13. phylo-node: A molecular phylogenetic toolkit using Node.js.

    Science.gov (United States)

    O'Halloran, Damien M

    2017-01-01

    Node.js is an open-source and cross-platform environment that provides a JavaScript codebase for back-end server-side applications. JavaScript has been used to develop very fast and user-friendly front-end tools for bioinformatic and phylogenetic analyses. However, no such toolkits are available using Node.js to conduct comprehensive molecular phylogenetic analysis. To address this problem, I have developed, phylo-node, which was developed using Node.js and provides a stable and scalable toolkit that allows the user to perform diverse molecular and phylogenetic tasks. phylo-node can execute the analysis and process the resulting outputs from a suite of software options that provides tools for read processing and genome alignment, sequence retrieval, multiple sequence alignment, primer design, evolutionary modeling, and phylogeny reconstruction. Furthermore, phylo-node enables the user to deploy server dependent applications, and also provides simple integration and interoperation with other Node modules and languages using Node inheritance patterns, and a customized piping module to support the production of diverse pipelines. phylo-node is open-source and freely available to all users without sign-up or login requirements. All source code and user guidelines are openly available at the GitHub repository: https://github.com/dohalloran/phylo-node.

  14. Abnormal position of lymph nodes in a freemartin sheep

    Directory of Open Access Journals (Sweden)

    Salazar PA

    2012-03-01

    Full Text Available Angela M Gonella-Diaza, Luz Zoraya Duarte, Sergio Dominguez, Pedro A SalazarClínica de Grandes Animales, Facultad de Medicina Veterinaria y de Zootecnia, Universidad Cooperativa de Colombia, Bucaramanga, Santander, ColombiaAbstract: In this freemartin case report the authors present the clinical and morphological findings of a freemartin ewe with an abnormal position of two lymph nodes. Freemartins, infertile females from mixed-sex twin pregnancies, are chimeras, having two cell populations: one of their own (XX DNA and one from their male twin (XY DNA. Freemartins can have varying degrees of phenotypic masculinization, including, in some cases, having active male gonads and exhibiting male behaviors such as heat detection and aggressiveness. During the clinical examination of the freemartin ewe, a morphological abnormality of the vulva, the presence of scrotal sacs, and a lack of mammary tissue development were noted. On inspection of the vaginal channel, an extremely enlarged clitoris, resembling a penis, was found. The clinical evidence suggested freemartinism. After the karyotyping diagnosis confirmation, a necropsy was performed and samples were taken for histology and immunohistochemistry. There were two structures found in the scrotal sacs; however, these were found to be lymph nodes, not testicles, and this was confirmed by CD3 lymph protein coloration. On histological study, the phallic structure showed corpus cavernosum and tunica albuginea. The testicles were found retained inside the abdominal cavity, with the presence of atrophic seminiferous tubules. Although the position of the testicles in freemartins has been reported as highly variable, this is the first time, to the best of the authors' knowledge, that a case has been reported where lymph nodes have been found inside the scrotal sacs. It is possible that these were the inguinal lymph nodes, trapped inside the scrotum during fetal growth and development.Keywords: freemartinism

  15. Indications of sentinel node biopsy in thin melanoma

    Directory of Open Access Journals (Sweden)

    Fernanda Braga Silva

    2010-06-01

    Full Text Available Objective: To assess data on survival, recurrence and histological factors in positive and negative sentinel lymph nodes in thin melanoma cases. Methods: A systematic review was conducted on observational studies in four databases (Cochrane Library, Medline, Embase and Lilacs. Positive and negative micrometastases in sentinel lymph node biopsy were compared regarding the clinical outcomes – death and recurrence – and six histological factors – vertical growth phase, Breslow thickness, Clark level, ulceration, regression and mitosis rate. Results: Positive sentinel lymph node is statistically associated with greater risk of death in six studies (OR: 7.2; 95%CI [2.37-21.83]; I2 0% and also to recurrence in three studies (OR: 30.7; 95%CI [12.58-74.92]; I2 36%. Comparing positive and negative groups, the histological factors predicting positive sentinel nodes and poor prognosis were: mitosis rate ≥ 5/mm2 (OR: 16.29; 95%CI [3.64-72.84]; I2 40%; VGP (OR: 2.93; 95%CI [1.08-7.93]; I2 59%; Breslow thickness ≥ 0.75mm (OR: 2.23; 95%CI [1.29-3.86]; I2 0%; and Clark level IV-V (OR: 1.61; 95%CI [1.06-2.44]; I2 34%. Conclusions: The statistically significant results associated with the presence of micrometastases in thin melanomas were Breslow thickness ≥ 0.75 mm, Clark level IV-V and mitoses ≥ 5/mm2, absence of regression. This histological factor of ulceration was associated, but not statistically significant.

  16. Sentinel lymph node biopsy in oral cancer

    DEFF Research Database (Denmark)

    Thomsen, Jørn Bo; Sørensen, Jens Ahm; Grupe, Peter;

    2005-01-01

    PURPOSE: To validate lymphatic mapping combined with sentinel lymph node biopsy as a staging procedure, and to evaluate the possible clinical implications of added oblique lymphoscintigraphy and/or tomography and test the intra- and interobserver reproducibility of lymphoscintigraphy. MATERIAL...... AND METHODS: Forty patients (17 F and 23 M, aged 32-90) with 24 T1 and 16 T2 squamous cell carcinoma of the oral cavity. Planar lymphoscintigraphy, emission and transmission tomography were performed. Detection and excision of the sentinel nodes were guided by a gamma probe. The sentinel nodes were step......-sectioning and stained with hematoxylin and eosin and cytokeratin (CK 1). Histology and follow-up were used as "gold standard". Tumor location, number of sentinel lymph nodes, metastasis, and recurrences were registered. Two observers evaluated the lymphoscintigraphic images to assess the inter-rater agreement. RESULTS...

  17. WHOI MVCO 12m Node ADCP SOS

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Wave observations from the 12m node ADCP in the Martha's Vineyard Coastal Observatory (MVCO) in the northwest Atlantic in coastal waters of North America. Extensive,...

  18. ARC Code TI: NodeMon

    Data.gov (United States)

    National Aeronautics and Space Administration — NodeMon is a resource utilization monitor tailored to the Altix architecture, but is applicable to any Linux system or cluster. It allows distributed resource...

  19. Axillary node metastasis from primary ovarian carcinoma

    Directory of Open Access Journals (Sweden)

    Trupti S Patel

    2014-01-01

    Full Text Available Metastasization and distinction from mammary carcinoma is of great clinical importance because of different treatment modalities. Here, we discuss a case of stage IIIC ovarian serous carcinoma, presenting with bilateral axillary nodes metastasis after 25 months interval of its initial presentation. Increased serum CA-125 level caused clinical suspicion. Computed tomography scan of abdomen and pelvis showed no residual disease or any abdominal lymphadenopathy. Mammography of both breast were normal. Bilateral axillary nodes were noted. Guided fine needle aspiration cytology (FNAC and biopsy of ovarian carcinoma to axillary node is a rare event. Its recogn done. Cytomorphology revealed poorly differentiated carcinoma, compatible to that of primary ovarian tumor. Thus, metastatic carcinoma to axillary node from ovary was confirmed. This case illustrates a rare metastatic presentation of ovarian carcinoma and unequivocal role of FNAC to provide rapid diagnosis and preferred to be first line diagnostic procedure.

  20. Dynamically reassigning a connected node to a block of compute nodes for re-launching a failed job

    Science.gov (United States)

    Budnik, Thomas A [Rochester, MN; Knudson, Brant L [Rochester, MN; Megerian, Mark G [Rochester, MN; Miller, Samuel J [Rochester, MN; Stockdell, William M [Byron, MN

    2012-03-20

    Methods, systems, and products for dynamically reassigning a connected node to a block of compute nodes for re-launching a failed job that include: identifying that a job failed to execute on the block of compute nodes because connectivity failed between a compute node assigned as at least one of the connected nodes for the block of compute nodes and its supporting I/O node; and re-launching the job, including selecting an alternative connected node that is actively coupled for data communications with an active I/O node; and assigning the alternative connected node as the connected node for the block of compute nodes running the re-launched job.

  1. Node Disjoint Multipath Routing Considering Link and Node Stability protocol: A characteristic Evaluation

    CERN Document Server

    Upadhayaya, Shuchita

    2010-01-01

    Mobile Ad hoc Networks are highly dynamic networks. Quality of Service (QoS) routing in such networks is usually limited by the network breakage due to either node mobility or energy depletion of the mobile nodes. Also, to fulfill certain quality parameters, presence of multiple node-disjoint paths becomes essential. Such paths aid in the optimal traffic distribution and reliability in case of path breakages. Thus, to cater various challenges in QoS routing in Mobile Add hoc Networks, a Node Disjoint Multipath Routing Considering Link and Node Stability (NDMLNR) protocol has been proposed by the authors. The metric used to select the paths takes into account the stability of the nodes and the corresponding links. This paper studies various challenges in the QoS routing and presents the characteristic evaluation of NDMLNR w.r.t various existing protocols in this area.

  2. Signaling completion of a message transfer from an origin compute node to a target compute node

    Science.gov (United States)

    Blocksome, Michael A.

    2011-02-15

    Signaling completion of a message transfer from an origin node to a target node includes: sending, by an origin DMA engine, an RTS message, the RTS message specifying an application message for transfer to the target node from the origin node; receiving, by the origin DMA engine, a remote get message containing a data descriptor for the message and a completion notification descriptor, the completion notification descriptor specifying a local memory FIFO data transfer operation for transferring data locally on the origin node; inserting, by the origin DMA engine in an injection FIFO buffer, the data descriptor followed by the completion notification descriptor; transferring, by the origin DMA engine to the target node, the message in dependence upon the data descriptor; and notifying, by the origin DMA engine, the application that transfer of the message is complete in dependence upon the completion notification descriptor.

  3. A node linkage approach for sequential pattern mining.

    Directory of Open Access Journals (Sweden)

    Osvaldo Navarro

    Full Text Available Sequential Pattern Mining is a widely addressed problem in data mining, with applications such as analyzing Web usage, examining purchase behavior, and text mining, among others. Nevertheless, with the dramatic increase in data volume, the current approaches prove inefficient when dealing with large input datasets, a large number of different symbols and low minimum supports. In this paper, we propose a new sequential pattern mining algorithm, which follows a pattern-growth scheme to discover sequential patterns. Unlike most pattern growth algorithms, our approach does not build a data structure to represent the input dataset, but instead accesses the required sequences through pseudo-projection databases, achieving better runtime and reducing memory requirements. Our algorithm traverses the search space in a depth-first fashion and only preserves in memory a pattern node linkage and the pseudo-projections required for the branch being explored at the time. Experimental results show that our new approach, the Node Linkage Depth-First Traversal algorithm (NLDFT, has better performance and scalability in comparison with state of the art algorithms.

  4. Model for the growth of the world airline network

    Science.gov (United States)

    Verma, T.; Araújo, N. A. M.; Nagler, J.; Andrade, J. S.; Herrmann, H. J.

    2016-06-01

    We propose a probabilistic growth model for transport networks which employs a balance between popularity of nodes and the physical distance between nodes. By comparing the degree of each node in the model network and the World Airline Network (WAN), we observe that the difference between the two is minimized for α≈2. Interestingly, this is the value obtained for the node-node correlation function in the WAN. This suggests that our model explains quite well the growth of airline networks.

  5. Defining nodes in complex brain networks.

    Science.gov (United States)

    Stanley, Matthew L; Moussa, Malaak N; Paolini, Brielle M; Lyday, Robert G; Burdette, Jonathan H; Laurienti, Paul J

    2013-11-22

    Network science holds great promise for expanding our understanding of the human brain in health, disease, development, and aging. Network analyses are quickly becoming the method of choice for analyzing functional MRI data. However, many technical issues have yet to be confronted in order to optimize results. One particular issue that remains controversial in functional brain network analyses is the definition of a network node. In functional brain networks a node represents some predefined collection of brain tissue, and an edge measures the functional connectivity between pairs of nodes. The characteristics of a node, chosen by the researcher, vary considerably in the literature. This manuscript reviews the current state of the art based on published manuscripts and highlights the strengths and weaknesses of three main methods for defining nodes. Voxel-wise networks are constructed by assigning a node to each, equally sized brain area (voxel). The fMRI time-series recorded from each voxel is then used to create the functional network. Anatomical methods utilize atlases to define the nodes based on brain structure. The fMRI time-series from all voxels within the anatomical area are averaged and subsequently used to generate the network. Functional activation methods rely on data from traditional fMRI activation studies, often from databases, to identify network nodes. Such methods identify the peaks or centers of mass from activation maps to determine the location of the nodes. Small (~10-20 millimeter diameter) spheres located at the coordinates of the activation foci are then applied to the data being used in the network analysis. The fMRI time-series from all voxels in the sphere are then averaged, and the resultant time series is used to generate the network. We attempt to clarify the discussion and move the study of complex brain networks forward. While the "correct" method to be used remains an open, possibly unsolvable question that deserves extensive

  6. Node Survival in Networks under Correlated Attacks.

    Directory of Open Access Journals (Sweden)

    Yan Hao

    Full Text Available We study the interplay between correlations, dynamics, and networks for repeated attacks on a socio-economic network. As a model system we consider an insurance scheme against disasters that randomly hit nodes, where a node in need receives support from its network neighbors. The model is motivated by gift giving among the Maasai called Osotua. Survival of nodes under different disaster scenarios (uncorrelated, spatially, temporally and spatio-temporally correlated and for different network architectures are studied with agent-based numerical simulations. We find that the survival rate of a node depends dramatically on the type of correlation of the disasters: Spatially and spatio-temporally correlated disasters increase the survival rate; purely temporally correlated disasters decrease it. The type of correlation also leads to strong inequality among the surviving nodes. We introduce the concept of disaster masking to explain some of the results of our simulations. We also analyze the subsets of the networks that were activated to provide support after fifty years of random disasters. They show qualitative differences for the different disaster scenarios measured by path length, degree, clustering coefficient, and number of cycles.

  7. Magnetic Resonance Evaluation of Transplanted Endometrial Carcinoma and Its Lymph Node Metastasis in Rabbits

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective: To establish a rabbit model of transplanted endometrial carcinoma with lymph node metastasis and observe its magnetic resonance imaging (MRI) features. Methods: VX2 tumor grafts were orthotopically embedded in the endometrium of rabbits, and 3 weeks after the transplantation, thetumor and its metastasis to the retroperitoneal lymph nodes were examined by MRI, and the signal intensities and size of the lymph nodes were compared with those of normal rabbits. Results: The orthotopic transplantation of the tumor grafts resulted in tumor growth in all the 12 recipient rabbits. The tumors infiltrated the serosa of the uterus and metastasized to the retroperitoneal lymph nodes 3 w after transplantation. MRI demonstrated that the lymph nodes of the tumor-bearing rabbits were larger in size than those of normal control rabbits, but the signal intensity of the lymph nodes was not significantly different between them. Conclusion: This transplanted endometrial carcinoma model is characterized by high success rate and similar tumor metastasis behaviors with human endometrial carcinoma, therefore may serve as a good model for testing the efficacy of contrast agents for MR lymphography.

  8. Research of the Node Operating System (NodeOS) in an Active Network

    Institute of Scientific and Technical Information of China (English)

    HUABei; LIZheng; XIONGYan; GELin

    2005-01-01

    This paper firstly proposes a three-layered NodeOS structural model that divides the functionality of NodeOS among hardware abstraction layer, resource man-agement layer and API layer, and discusses the primary functions of each layer. NodeOS built on this model will be open and programmable. Then, from the view of supporting fair and customized services, this paper puts forward a general NodeOS service model that defines threetypes of NodeOS services according to the tradeoiT between quality of service and cost of service, then specifies a general method to map special application-oriented services to NodeOS services, and lastly discusses the resource allocation policies and corresponding enforcement mechanisms. Finally, after analyzing the security requirements of active net, this paper puts forward a general but powerful security architecture for NodeOS, which embeds elementary security mechanisms in NodeOS by enforcing well-designed domain relations and encapsulating sensitive underlying interfaces, and provides further security services of authorization management and packet checking by integrating additional service facilities.

  9. Prognostic Implications of Lymph Node Yield and Lymph Node Ratio in Papillary Thyroid Carcinoma

    NARCIS (Netherlands)

    Nunes, Jonathan H. Vas; Clark, Jonathan R.; Gao, Kan; Chua, Elizabeth; Campbell, Peter; Niles, Navin; Gargya, Ash; Elliott, Michael S.

    2013-01-01

    Background: The lymph node yield (LNY) and the lymph node ratio (LNR) have been shown to be important prognostic factors in oral, colon, and gastric cancers. The role of the LNY and LNR in papillary thyroid cancer (PTC) is unclear. The aims of this study were to determine if a high LNR and a low LNY

  10. Current concepts of anatomy and electrophysiology of the sinus node.

    Science.gov (United States)

    Murphy, Cliona; Lazzara, Ralph

    2016-06-01

    The sinoatrial node, or sinus node, of humans is the principal pacemaker of the heart. Over the last century, studies have unraveled the complex molecular architecture of the sinus node and the expression of unique ion channels within its specialized myocytes. Aim of this review is to describe the embriology, the anatomy, the histology and the electrophisiology of the sinus node.

  11. Microvascular breast reconstruction and lymph node transfer for postmastectomy lymphedema patients.

    Science.gov (United States)

    Saaristo, Anne M; Niemi, Tarja S; Viitanen, Tiina P; Tervala, Tomi V; Hartiala, Pauliina; Suominen, Erkki A

    2012-03-01

    Postoperative lymphedema after breast cancer surgery is a challenging problem. Recently, a novel microvascular lymph node transfer technique provided a fresh hope for patients with lymphedema. We aimed to combine this new method with the standard breast reconstruction. During 2008-2010, we performed free lower abdominal flap breast reconstruction in 87 patients. For all patients with lymphedema symptoms (n = 9), we used a modified lower abdominal reconstruction flap containing lymph nodes and lymphatic vessels surrounding the superficial circumflex vessel pedicle. Operation time, donor site morbidity, and postoperative recovery between the 2 groups (lymphedema breast reconstruction and breast reconstruction) were compared. The effect on the postoperative lymphatic vessel function was examined. The average operation time was 426 minutes in the lymphedema breast reconstruction group and 391 minutes in the breast reconstruction group. The postoperative abdominal seroma formation was increased in patients with lymphedema. Postoperative lymphoscintigraphy demonstrated at least some improvement in lymphatic vessel function in 5 of 6 patients with lymphedema. The upper limb perimeter decreased in 7 of 9 patients. Physiotherapy and compression was no longer needed in 3 of 9 patients. Importantly, we found that human lymph nodes express high levels of endogenous lymphatic vessel growth factors. Transfer of the lymph nodes and the resulting endogenous growth factor expression may thereby induce the regrowth of lymphatic network in the axilla. No edema problems were detected in the lymph node donor area. Simultaneous breast and lymphatic reconstruction is an ideal option for patients who suffer from lymphedema after mastectomy and axillary dissection.

  12. Communication: Fixed-node errors in quantum Monte Carlo: Interplay of electron density and node nonlinearities

    Energy Technology Data Exchange (ETDEWEB)

    Rasch, Kevin M.; Hu, Shuming; Mitas, Lubos [Center for High Performance Simulation and Department of Physics, North Carolina State University, Raleigh, North Carolina 27695 (United States)

    2014-01-28

    We elucidate the origin of large differences (two-fold or more) in the fixed-node errors between the first- vs second-row systems for single-configuration trial wave functions in quantum Monte Carlo calculations. This significant difference in the valence fixed-node biases is studied across a set of atoms, molecules, and also Si, C solid crystals. We show that the key features which affect the fixed-node errors are the differences in electron density and the degree of node nonlinearity. The findings reveal how the accuracy of the quantum Monte Carlo varies across a variety of systems, provide new perspectives on the origins of the fixed-node biases in calculations of molecular and condensed systems, and carry implications for pseudopotential constructions for heavy elements.

  13. Communication: Fixed-node errors in quantum Monte Carlo: Interplay of electron density and node nonlinearities

    Science.gov (United States)

    Rasch, Kevin M.; Hu, Shuming; Mitas, Lubos

    2014-01-01

    We elucidate the origin of large differences (two-fold or more) in the fixed-node errors between the first- vs second-row systems for single-configuration trial wave functions in quantum Monte Carlo calculations. This significant difference in the valence fixed-node biases is studied across a set of atoms, molecules, and also Si, C solid crystals. We show that the key features which affect the fixed-node errors are the differences in electron density and the degree of node nonlinearity. The findings reveal how the accuracy of the quantum Monte Carlo varies across a variety of systems, provide new perspectives on the origins of the fixed-node biases in calculations of molecular and condensed systems, and carry implications for pseudopotential constructions for heavy elements.

  14. Node Deployment with k-Connectivity in Sensor Networks for Crop Information Full Coverage Monitoring

    Directory of Open Access Journals (Sweden)

    Naisen Liu

    2016-12-01

    Full Text Available Wireless sensor networks (WSNs are suitable for the continuous monitoring of crop information in large-scale farmland. The information obtained is great for regulation of crop growth and achieving high yields in precision agriculture (PA. In order to realize full coverage and k-connectivity WSN deployment for monitoring crop growth information of farmland on a large scale and to ensure the accuracy of the monitored data, a new WSN deployment method using a genetic algorithm (GA is here proposed. The fitness function of GA was constructed based on the following WSN deployment criteria: (1 nodes must be located in the corresponding plots; (2 WSN must have k-connectivity; (3 WSN must have no communication silos; (4 the minimum distance between node and plot boundary must be greater than a specific value to prevent each node from being affected by the farmland edge effect. The deployment experiments were performed on natural farmland and on irregular farmland divided based on spatial differences of soil nutrients. Results showed that both WSNs gave full coverage, there were no communication silos, and the minimum connectivity of nodes was equal to k. The deployment was tested for different values of k and transmission distance (d to the node. The results showed that, when d was set to 200 m, as k increased from 2 to 4 the minimum connectivity of nodes increases and is equal to k. When k was set to 2, the average connectivity of all nodes increased in a linear manner with the increase of d from 140 m to 250 m, and the minimum connectivity does not change.

  15. Node Deployment with k-Connectivity in Sensor Networks for Crop Information Full Coverage Monitoring

    Science.gov (United States)

    Liu, Naisen; Cao, Weixing; Zhu, Yan; Zhang, Jingchao; Pang, Fangrong; Ni, Jun

    2016-01-01

    Wireless sensor networks (WSNs) are suitable for the continuous monitoring of crop information in large-scale farmland. The information obtained is great for regulation of crop growth and achieving high yields in precision agriculture (PA). In order to realize full coverage and k-connectivity WSN deployment for monitoring crop growth information of farmland on a large scale and to ensure the accuracy of the monitored data, a new WSN deployment method using a genetic algorithm (GA) is here proposed. The fitness function of GA was constructed based on the following WSN deployment criteria: (1) nodes must be located in the corresponding plots; (2) WSN must have k-connectivity; (3) WSN must have no communication silos; (4) the minimum distance between node and plot boundary must be greater than a specific value to prevent each node from being affected by the farmland edge effect. The deployment experiments were performed on natural farmland and on irregular farmland divided based on spatial differences of soil nutrients. Results showed that both WSNs gave full coverage, there were no communication silos, and the minimum connectivity of nodes was equal to k. The deployment was tested for different values of k and transmission distance (d) to the node. The results showed that, when d was set to 200 m, as k increased from 2 to 4 the minimum connectivity of nodes increases and is equal to k. When k was set to 2, the average connectivity of all nodes increased in a linear manner with the increase of d from 140 m to 250 m, and the minimum connectivity does not change. PMID:27941704

  16. Node Deployment with k-Connectivity in Sensor Networks for Crop Information Full Coverage Monitoring.

    Science.gov (United States)

    Liu, Naisen; Cao, Weixing; Zhu, Yan; Zhang, Jingchao; Pang, Fangrong; Ni, Jun

    2016-12-09

    Wireless sensor networks (WSNs) are suitable for the continuous monitoring of crop information in large-scale farmland. The information obtained is great for regulation of crop growth and achieving high yields in precision agriculture (PA). In order to realize full coverage and k-connectivity WSN deployment for monitoring crop growth information of farmland on a large scale and to ensure the accuracy of the monitored data, a new WSN deployment method using a genetic algorithm (GA) is here proposed. The fitness function of GA was constructed based on the following WSN deployment criteria: (1) nodes must be located in the corresponding plots; (2) WSN must have k-connectivity; (3) WSN must have no communication silos; (4) the minimum distance between node and plot boundary must be greater than a specific value to prevent each node from being affected by the farmland edge effect. The deployment experiments were performed on natural farmland and on irregular farmland divided based on spatial differences of soil nutrients. Results showed that both WSNs gave full coverage, there were no communication silos, and the minimum connectivity of nodes was equal to k. The deployment was tested for different values of k and transmission distance (d) to the node. The results showed that, when d was set to 200 m, as k increased from 2 to 4 the minimum connectivity of nodes increases and is equal to k. When k was set to 2, the average connectivity of all nodes increased in a linear manner with the increase of d from 140 m to 250 m, and the minimum connectivity does not change.

  17. Predictors of lymph node count in colorectal cancer resections: data from US nationwide prospective cohort studies.

    Science.gov (United States)

    Morikawa, Teppei; Tanaka, Noriko; Kuchiba, Aya; Nosho, Katsuhiko; Yamauchi, Mai; Hornick, Jason L; Swanson, Richard S; Chan, Andrew T; Meyerhardt, Jeffrey A; Huttenhower, Curtis; Schrag, Deborah; Fuchs, Charles S; Ogino, Shuji

    2012-08-01

    To identify factors that influence the total and negative lymph node counts in colorectal cancer resection specimens independent of pathologists and surgeons. We used multivariate negative binomial regression. Covariates included age, sex, body mass index, family history of colorectal carcinoma, year of diagnosis, hospital setting, tumor location, resected colorectal length (specimen length), tumor size, circumferential growth, TNM stage, lymphocytic reactions and other pathological features, and tumor molecular features (microsatellite instability, CpG island methylator phenotype, long interspersed nucleotide element 1 [LINE-1] methylation, and BRAF, KRAS, and PIK3CA mutations). Two US nationwide prospective cohort studies. Patients with rectal and colon cancer (N=918). The negative and total node counts (continuous). Specimen length, tumor size, ascending colon location, T3N0M0 stage, and year of diagnosis were positively associated with the negative node count (all P.002). Mutation of KRAS might also be positively associated with the negative node count (P=.03; borderline significance considering multiple hypothesis testing). Among node-negative (stages I and II) cases, specimen length, tumor size, and ascending colon location remained significantly associated with the node count (all P.002), and PIK3CA and KRAS mutations might also be positively associated (P=.03 and P=.049, respectively, with borderline significance). This molecular pathological epidemiology study shows that specimen length, tumor size, tumor location, TNM stage, and year of diagnosis are operator-independent predictors of the lymph node count. These crucial variables should be examined in any future evaluation of the adequacy of lymph node harvest and nodal staging when devising individualized treatment plans for patients with colorectal cancer.

  18. Measure of Node Similarity in Multilayer Networks

    DEFF Research Database (Denmark)

    Møllgaard, Anders; Zettler, Ingo; Dammeyer, Jesper

    2016-01-01

    The weight of links in a network is often related to the similarity of thenodes. Here, we introduce a simple tunable measure for analysing the similarityof nodes across different link weights. In particular, we use the measure toanalyze homophily in a group of 659 freshman students at a large...... university.Our analysis is based on data obtained using smartphones equipped with customdata collection software, complemented by questionnaire-based data. The networkof social contacts is represented as a weighted multilayer network constructedfrom different channels of telecommunication as well as data...... might bepresent in one layer of the multilayer network and simultaneously be absent inthe other layers. For a variable such as gender, our measure reveals atransition from similarity between nodes connected with links of relatively lowweight to dis-similarity for the nodes connected by the strongest...

  19. Vital nodes identification in complex networks

    Science.gov (United States)

    Lü, Linyuan; Chen, Duanbing; Ren, Xiao-Long; Zhang, Qian-Ming; Zhang, Yi-Cheng; Zhou, Tao

    2016-09-01

    Real networks exhibit heterogeneous nature with nodes playing far different roles in structure and function. To identify vital nodes is thus very significant, allowing us to control the outbreak of epidemics, to conduct advertisements for e-commercial products, to predict popular scientific publications, and so on. The vital nodes identification attracts increasing attentions from both computer science and physical societies, with algorithms ranging from simply counting the immediate neighbors to complicated machine learning and message passing approaches. In this review, we clarify the concepts and metrics, classify the problems and methods, as well as review the important progresses and describe the state of the art. Furthermore, we provide extensive empirical analyses to compare well-known methods on disparate real networks, and highlight the future directions. In spite of the emphasis on physics-rooted approaches, the unification of the language and comparison with cross-domain methods would trigger interdisciplinary solutions in the near future.

  20. Predicting missing links via correlation between nodes

    CERN Document Server

    Liao, Hao; Zhang, Yi-Cheng

    2014-01-01

    As a fundamental problem in many different fields, link prediction aims to estimate the likelihood of an existing link between two nodes based on the observed information. Since this problem is related to many applications ranging from uncovering missing data to predicting the evolution of networks, link prediction has been intensively investigated recently and many methods have been proposed so far. The essential challenge of link prediction is to estimate the similarity between nodes. Most of the existing methods are based on the common neighbor index and its variants. In this paper, we propose to calculate the similarity between nodes by the correlation coefficient. This method is found to be very effective when applied to calculate similarity based on high order paths. We finally fuse the correlation-based method with the resource allocation method, and find that the combined method can substantially outperform the existing methods, especially in sparse networks.

  1. Vital nodes identification in complex networks

    CERN Document Server

    Lü, Linyuan; Ren, Xiao-Long; Zhang, Qian-Ming; Zhang, Yi-Cheng; Zhou, Tao

    2016-01-01

    Real networks exhibit heterogeneous nature with nodes playing far different roles in structure and function. To identify vital nodes is thus very significant, allowing us to control the outbreak of epidemics, to conduct advertisements for e-commercial products, to predict popular scientific publications, and so on. The vital nodes identification attracts increasing attentions from both computer science and physical societies, with algorithms ranging from simply counting the immediate neighbors to complicated machine learning and message passing approaches. In this review, we clarify the concepts and metrics, classify the problems and methods, as well as review the important progresses and describe the state of the art. Furthermore, we provide extensive empirical analyses to compare well-known methods on disparate real networks, and highlight the future directions. In despite of the emphasis on physics-rooted approaches, the unification of the language and comparison with cross-domain methods would trigger int...

  2. Energy Options for Wireless Sensor Nodes

    Directory of Open Access Journals (Sweden)

    Chris Knight

    2008-12-01

    Full Text Available Reduction in size and power consumption of consumer electronics has opened up many opportunities for low power wireless sensor networks. One of the major challenges is in supporting battery operated devices as the number of nodes in a network grows. The two main alternatives are to utilize higher energy density sources of stored energy, or to generate power at the node from local forms of energy. This paper reviews the state-of-the art technology in the field of both energy storage and energy harvesting for sensor nodes. The options discussed for energy storage include batteries, capacitors, fuel cells, heat engines and betavoltaic systems. The field of energy harvesting is discussed with reference to photovoltaics, temperature gradients, fluid flow, pressure variations and vibration harvesting.

  3. Imaging Classification of Cervical Lymph Nodes

    Directory of Open Access Journals (Sweden)

    Gh. Bakhshandepour

    2008-01-01

    Full Text Available Nearly four decades, Rouviere classification, which is a clinically based system, was the only system for cervical adenopathy classification. The best possible classification of cervical nodal disease may be accomplished by using both clinical palpation and also informations provided by imaging, because imaging can reveal clinically silent lymph nodes. most head and neck tumors spread to the neck nodes as a part of their natural history ,depending on the primary site. Up to 80% of patients with upper aerodigestive mucosal malignancies will have cervical nodal metastasis"nat presentation.The occurrence of nodal metastasis has a profound effect on the management and prognosis of the patients .nodal metastasis is the most important prognostic factor in squamous cell carcinoma of the head and neck. In general it decreases the overall survival by half, and extracapsular spread worsens the prognosis by another half. Our purpose in this presentation is to review imaging classification of cervical lymph nodes.

  4. Node discovery problem for a social network

    CERN Document Server

    Maeno, Yoshiharu

    2007-01-01

    This paper presents a practical heuristic algorithm to address a node discovery problem. The node discovery problem is to discover a clue on the person, who does not appear in the observed records, but is relevant functionally in affecting decision-making and behavior of an organization. We define two topological relevance of a node in a social network (global and local relevance). Association between the topological relevance and the functional relevance is studied with a few example networks in criminal organizations. We propose a heuristic algorithm to infer an invisible, functionally relevant person. Its performance (precision, recall, and F value) is demonstrated with a simulation experiment using a network derived from the Watts-Strogatz (WS) model.

  5. Node degree distribution in spanning trees

    Science.gov (United States)

    Pozrikidis, C.

    2016-03-01

    A method is presented for computing the number of spanning trees involving one link or a specified group of links, and excluding another link or a specified group of links, in a network described by a simple graph in terms of derivatives of the spanning-tree generating function defined with respect to the eigenvalues of the Kirchhoff (weighted Laplacian) matrix. The method is applied to deduce the node degree distribution in a complete or randomized set of spanning trees of an arbitrary network. An important feature of the proposed method is that the explicit construction of spanning trees is not required. It is shown that the node degree distribution in the spanning trees of the complete network is described by the binomial distribution. Numerical results are presented for the node degree distribution in square, triangular, and honeycomb lattices.

  6. Functional Testing of Wireless Sensor Node Designs

    DEFF Research Database (Denmark)

    Virk, Kashif M.; Madsen, Jan

    2007-01-01

    Wireless sensor networks are networked embedded computer systems with stringent power, performance, cost and form-factor requirements along with numerous other constraints related to their pervasiveness and ubiquitousness. Therefore, only a systematic design methdology coupled with an efficient...... test approach can enable their conformance to design and deployment specifications. We discuss off-line, hierarchical, functional testing of complete wireless sensor nodes containing configurable logic through a combination of FPGA-based board test and Software-Based Self-Test (SBST) techniques....... The proposed functional test methodology has been applied to a COTS-based sensor node development platform and can be applied, in general, for testing all types of wireless sensor node designs....

  7. The value of peripheral nodes in controlling multilayer networks

    CERN Document Server

    Zhang, Yan; Schweitzer, Frank

    2015-01-01

    We analyze the controllability of a two-layer network, where driver nodes can be chosen only from one layer. Each layer contains a scale-free network with directed links. The dynamics of nodes depends on the incoming links from other nodes (reputation dynamics). We find that the controllable part of the network is larger when choosing peripherial nodes to connect the two layers. The control is as efficient for peripherial nodes as driver nodes as it is for more central nodes. If we assume a cost to utilize nodes which is proportional to their degree, utilizing peripherial nodes to connect the two layers or to act as driver nodes is not only the most cost-efficient solution, it is also the one that gives us the best performance in controlling the two-layer network.

  8. Information Capacity of Energy Harvesting Sensor Nodes

    CERN Document Server

    Rajesh, R

    2010-01-01

    Sensor nodes with energy harvesting sources are gaining popularity due to their ability to improve the network life time and are becoming a preferred choice supporting 'green communication'. We study such a sensor node with an energy harvesting source and compare various architectures by which the harvested energy is used. We find its Shannon capacity when it is transmitting its observations over an AWGN channel and show that the capacity achieving energy management policy is the same as the throughput optimal policy. We also obtain the capacity for the system with energy inefficiencies in storage and an achievable rate when energy conserving sleep-wake modes are supported.

  9. Refining Nodes and Edges of State Machines

    DEFF Research Database (Denmark)

    Hallerstede, Stefan; Snook, Colin

    2011-01-01

    State machines are hierarchical automata that are widely used to structure complex behavioural specifications. We develop two notions of refinement of state machines, node refinement and edge refinement. We compare the two notions by means of examples and argue that, by adopting simple convention...... refinement theory and UML-B state machine refinement influences the style of node refinement. Hence we propose a method with direct proof of state machine refinement avoiding the detour via Event-B that is needed by UML-B....

  10. Optimal Placement of Wavelength Converting Nodes

    DEFF Research Database (Denmark)

    Belotti, Pietro; Stidsen, Thomas K.

    2001-01-01

    The all optical network using WDM and optical nodes (OXC's) seems to be a possibility in a near future. The consensus to day seems to be that optical wavelength conversions is un-realistic for several decades, hence wavelength blocking will happen in the all optical networks. A possible solution ...... to this problem could be to include digital nodes (DXC's) in the network at the right places. In this article we present a linear programming model which optimizes the placement of these more expensive DXC's in the network....

  11. Automatic Testing of a CANopen Node

    OpenAIRE

    Liang, Hui

    2013-01-01

    This Bachelor’s thesis was commissioned by TK Engineering Oy in Vaasa. The goals of the thesis were to test a prototype CANopen node, called UWASA Node for conformance to the CiA 301 standard, and to develop the automatic performance test software and the automatic CiA 401 test software. A test report that describes to the designer what needs to be corrected and improved is made in this thesis. For the CiA 301 test there is a CANopen conformance test tool that can be used. The automatic perfo...

  12. Reliability of sentinel node procedure for lymph node staging in prostate cancer patients at high risk for lymph node involvement

    NARCIS (Netherlands)

    Van den Bergh, Laura; Joniau, Steven; Haustermans, Karin; Deroose, Christophe M.; Isebaert, Sofie; Oyen, Raymond; Mottaghy, Felix M.; Ameye, Filip; Berkers, Joost; Van Poppel, Hendrik; Lerut, Evelyne

    2015-01-01

    PURPOSE Accurate staging modalities to diagnose lymph node involvement in patients with prostate cancer (PCa) are lacking. We wanted to prospectively assess sensitivity, specificity, and positive predictive value (PPV) and negative predictive value of (11)C-choline positron emission tomography (PET)

  13. Detection of sentinel nodes with radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Yokoyama, Kunihiko; Michigishi, Takatoshi; Kinuya, Seigo; Konishi, Shota; Nakajima, Kenichi; Tonami, Norihisa [Kanazawa Univ. (Japan). School of Medicine

    2000-10-01

    Sentinel lymph nodes have been found to be an indicator of lymph node metastasis in breast cancer. In Japan, the theory and concept of sentinel lymph nodes in breast cancer have begun to be applied to carcinomas of the digestive system. Based on clinical experience in the detection of sentinel lymph nodes with radiopharmaceuticals, differences and similarities between the radiopharmaceuticals, methods, and techniques used to detect sentinel lymph nodes have been assessed in relation to breast cancer and carcinomas of the digestive system (including carcinomas of the esophagus and large intestine). The greatest difference between the methods used for breast and digestive cancers is the site of administration of the radiopharmaceutical. In breast cancer, the radiopharmaceutical is administered into a superficial organ (i.e., the mammary gland), whereas in carcinomas of the digestive system, it is administered into a deep organ (i.e., digestive tract). Another obvious difference is in lymph flow, i.e., the flow of the mammary glands is subcutaneous whereas lymph flow in the digestive tract is submucosal. Two radionuclide diagnostic methods are available to detect sentinel lymph nodes: sentinel lymphoscintigraphy with a gamma camera and a method that involves the use of a gamma probe intraoperatively. Radiopharmaceuticals used to detect sentinel lymph nodes must be smoothly transferred from the site of administration into the lymph, and uptake by the sentinel lymph node must continue for a long time without excessive flowing to lower reaches. The optimal particle size remains a matter of controversy, and no radiopharmaceuticals appropriate for lymphoscintigraphy have ever been approved in Japan. The authors compared the pharmacokinetics of three different radiopharmaceuticals used for sentinel lymphoscintigraphy in breast cancer ({sup 99m}Tc-labeled albumin, {sup 99m}Tc-labeled tin colloid, and {sup 99m}Tc-labeled phytic acid) and founded that the detection rate was

  14. Use of a Hybrid Edge Node-Centroid Node Approach to Thermal Modeling

    Science.gov (United States)

    Peabody, Hume L.

    2010-01-01

    A recent proposal submitted for an ESA mission required that models be delivered in ESARAD/ESATAN formats. ThermalDesktop was the preferable analysis code to be used for model development with a conversion done as the final step before delivery. However, due to some differences between the capabilities of the two codes, a unique approach was developed to take advantage of the edge node capability of ThermalDesktop while maintaining the centroid node approach used by ESARAD. In essence, two separate meshes were used: one for conduction and one for radiation. The conduction calculations were eliminated from the radiation surfaces and the capacitance and radiative calculations were eliminated from the conduction surfaces. The resulting conduction surface nodes were coincident with all nodes of the radiation surface and were subsequently merged, while the nodes along the edges remained free. Merging of nodes on the edges of adjacent surfaces provided the conductive links between surfaces. Lastly, all nodes along edges were placed into the subnetwork and the resulting supernetwork included only the nodes associated with radiation surfaces. This approach had both benefits and disadvantages. The use of centroid, surface based radiation reduces the overall size of the radiation network, which is often the most computationally intensive part of the modeling process. Furthermore, using the conduction surfaces and allowing ThermalDesktop to calculate the conduction network can save significant time by not having to manually generate the couplings. Lastly, the resulting GMM/TMM models can be exported to formats which do not support edge nodes. One drawback, however, is the necessity to maintain two sets of surfaces. This requires additional care on the part of the analyst to ensure communication between the conductive and radiative surfaces in the resulting overall network. However, with more frequent use of this technique, the benefits of this approach can far outweigh the

  15. Measure of Node Similarity in Multilayer Networks.

    Directory of Open Access Journals (Sweden)

    Anders Mollgaard

    Full Text Available The weight of links in a network is often related to the similarity of the nodes. Here, we introduce a simple tunable measure for analysing the similarity of nodes across different link weights. In particular, we use the measure to analyze homophily in a group of 659 freshman students at a large university. Our analysis is based on data obtained using smartphones equipped with custom data collection software, complemented by questionnaire-based data. The network of social contacts is represented as a weighted multilayer network constructed from different channels of telecommunication as well as data on face-to-face contacts. We find that even strongly connected individuals are not more similar with respect to basic personality traits than randomly chosen pairs of individuals. In contrast, several socio-demographics variables have a significant degree of similarity. We further observe that similarity might be present in one layer of the multilayer network and simultaneously be absent in the other layers. For a variable such as gender, our measure reveals a transition from similarity between nodes connected with links of relatively low weight to dis-similarity for the nodes connected by the strongest links. We finally analyze the overlap between layers in the network for different levels of acquaintanceships.

  16. Measure of Node Similarity in Multilayer Networks

    Science.gov (United States)

    Mollgaard, Anders; Zettler, Ingo; Dammeyer, Jesper; Jensen, Mogens H.; Lehmann, Sune; Mathiesen, Joachim

    2016-01-01

    The weight of links in a network is often related to the similarity of the nodes. Here, we introduce a simple tunable measure for analysing the similarity of nodes across different link weights. In particular, we use the measure to analyze homophily in a group of 659 freshman students at a large university. Our analysis is based on data obtained using smartphones equipped with custom data collection software, complemented by questionnaire-based data. The network of social contacts is represented as a weighted multilayer network constructed from different channels of telecommunication as well as data on face-to-face contacts. We find that even strongly connected individuals are not more similar with respect to basic personality traits than randomly chosen pairs of individuals. In contrast, several socio-demographics variables have a significant degree of similarity. We further observe that similarity might be present in one layer of the multilayer network and simultaneously be absent in the other layers. For a variable such as gender, our measure reveals a transition from similarity between nodes connected with links of relatively low weight to dis-similarity for the nodes connected by the strongest links. We finally analyze the overlap between layers in the network for different levels of acquaintanceships. PMID:27300084

  17. Inguinal lymph node metastasis of colon cancer

    Directory of Open Access Journals (Sweden)

    Sloane McGraw

    2011-01-01

    Full Text Available We present a case of adenocarcinoma of colon with unusual metastasis to inguinal lymph nodes. Our patient is a young male with bilateral inguinal lymphadenopathy, bone pains, and jaundice who presented as carcinoma of unknown primary. He was diagnosed as widely metastatic adenocarcinoma of colon for which he received chemotherapy and has had a good response to the treatment.

  18. Groin surgery and the sentinel lymph node

    NARCIS (Netherlands)

    de Hullu, JA; van der Zee, AGJ

    2003-01-01

    Vulvar cancer is a rare disease. Squamous-cell carcinomas account for 90% of vulvar cancers. The main mode of spread is lymphogenic to the inguinofemoral lymph nodes. Therefore, elective unior bilateral inguinofemoral lymphadenectomy is part of the standard treatment in combination with radical (wid

  19. Network Design with Node Degree Balance Constraints

    DEFF Research Database (Denmark)

    Pedersen, Michael Berliner; Crainic, Teodor Gabriel

    This presentation discusses an extension to the network design model where there in addition to the flow conservation constraints also are constraints that require design conservation. This means that the number of arcs entering and leaving a node must be the same. As will be shown the model has ...

  20. Lithography strategy for 65-nm node

    Science.gov (United States)

    Borodovsky, Yan A.; Schenker, Richard E.; Allen, Gary A.; Tejnil, Edita; Hwang, David H.; Lo, Fu-Chang; Singh, Vivek K.; Gleason, Robert E.; Brandenburg, Joseph E.; Bigwood, Robert M.

    2002-07-01

    Intel will start high volume manufacturing (HVM) of the 65nm node in 2005. Microprocessor density and performance trends will continue to follow Moore's law and cost-effective patterning solutions capable of supporting it have to be found, demonstrated and developed during 2002-2004. Given the uncertainty regarding the readiness and respective capabilities of 157nm and 193nm lithography to support 65nm technology requirements, Intel is developing both lithographic options and corresponding infrastructure with the intent to use both options in manufacturing. Development and use of dual lithographic options for a given technology node in manufacturing is not a new paradigm for Intel: whenever introduction of a new exposure wavelength presented excessive risk to the manufacturing schedule, Intel developed parallel patterning approaches in time for the manufacturing ramp. Both I-line and 248nm patterning solutions were developed and successfully used in manufacturing of the 350nm node at Intel. Similarly, 248nm and 193nm patterning solutions were fully developed for 130nm node high volume manufacturing.

  1. Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis.

    Science.gov (United States)

    Dubey, Lalit Kumar; Karempudi, Praneeth; Luther, Sanjiv A; Ludewig, Burkhard; Harris, Nicola L

    2017-08-28

    Lymphatic growth (lymphangiogenesis) within lymph nodes functions to promote dendritic cell entry and effector lymphocyte egress in response to infection or inflammation. Here we demonstrate a crucial role for lymphotoxin-beta receptor (LTβR) signaling to fibroblastic reticular cells (FRCs) by lymphotoxin-expressing B cells in driving mesenteric lymph node lymphangiogenesis following helminth infection. LTβR ligation on fibroblastic reticular cells leads to the production of B-cell-activating factor (BAFF), which synergized with interleukin-4 (IL-4) to promote the production of the lymphangiogenic factors, vascular endothelial growth factors (VEGF)-A and VEGF-C, by B cells. In addition, the BAFF-IL-4 synergy augments expression of lymphotoxin by antigen-activated B cells, promoting further B cell-fibroblastic reticular cell interactions. These results underlie the importance of lymphotoxin-dependent B cell-FRC cross talk in driving the expansion of lymphatic networks that function to promote and maintain immune responsiveness.The growth of lymph nodes in response to infection requires lymphangiogenesis. Dubey et al. show that the mesenteric lymph node lymphangiogenesis upon helminth infection depends on the signaling loop between the B and fibroblastic reticular cells (FRCs), whereby the FRCs respond to lymphotoxin secreted by B cells by releasing B cell activating factor.

  2. IDIS Small Bodies and Dust Node

    Science.gov (United States)

    de Sanctis, M. C.; Capria, M. T.; Carraro, F.; Fonte, S.; Giacomini, L.; Turrini, D.

    2009-04-01

    The EuroPlaNet information service provides access to lists of researchers, laboratories and data archives relevant to many aspects of planetary and space physics. Information can be accessed through EuroPlaNet website or, for advanced searches, via web-services available at the different thematic nodes. The goal of IDIS is to provide easy-to-use access to resources like people, laboratories, modeling activities and data archives related to planetary sciences. The development of IDIS is an international effort started under the European Commission's 6th Framework Programme and which will expand its capabilities during the 7th Framework Programme, as part of the Capacities Specific Programme/Research Infrastructures. IDIS is complemented by a set of other EuroPlaNet web-services maintained under the responsibility of separate institutions. Each activity maintains its own web-portal with cross-links pointing to the other elements of EuroPlaNet. General access is provided via the EuroPlaNet Homepage. IDIS is not a repository of original data but rather supports the access to various data sources. The final goal of IDIS is to provide Virtual Observatory tools for the access to data from laboratory measurements and ground- and spaced-based observations to modeling results, allowing the combination of as divergent data sources as feasible. IDIS is built around four scientific nodes located in different European countries. Each node deals with a subset of the disciplines related to planetary sciences and, working in cooperation with international experts in these fields, provides a wealth of information to the international planetary science community. The EuroPlaNet IDIS thematic node "Small Bodies and Dust Node" is hosted by the Istituto di Fisica dello Spazio Interplanetario and is established in close cooperation with the Istituto di Astrofisica Spaziale. Both these institutes are part of the Istituto Nazionale di Astrofisica (INAF). The IDIS Small Bodies and Dust

  3. Penile lymphoscintigraphy for sentinel node identification

    Energy Technology Data Exchange (ETDEWEB)

    Valdes Olmos, R.A.; Hoefnagel, C.A. [Netherlands Cancer Inst., Amsterdam (Netherlands). Dept. of Nuclear Medicine; Tanis, P.J.; Jansen, L.; Nieweg, O.E. [Netherlands Cancer Inst., Amsterdam (Netherlands). Dept. of Surgery; Meinhardt, W.; Horenblas, S. [Netherlands Cancer Inst., Amsterdam (Netherlands). Dept. of Urology

    2001-05-01

    Lymphoscintigraphy for sentinel node (SN) identification has been extensively validated in breast cancer and melanoma. The aim of this study was to evaluate the findings of lymphoscintigraphy for SN identification in carcinoma of the penis. Lymphoscintigraphy was performed in 74 consecutive patients (mean age 62.2 years, range 28-87 years) with clinically lymph node-negative squamous cell carcinoma of the penis (stage T2 or greater). Following local anaesthesia by xy-locaine 10% spray, technetium-99m nanocolloid (mean dose 64.8 MBq, range 40-131 MBq) in a volume of 0.3-0.4 ml was injected intradermally around the tumour. Shortly after injection, a 20-min dynamic study was performed with a dual-head gamma camera; subsequently, static anterior and lateral images were obtained at 30 min and 2 h using simultaneous cobalt-57 flood source transmission scanning. {sup 57}Co-assisted skin marking defined SN location for gamma probe/blue dye-guided biopsy, which was performed the next day. The SN visualization rate was 97% (72/74). Lymphatic drainage was bilateral in 81% of the cases (58/72), exclusively to the left groin in 13% (9/72) and only to the right groin in 6%. Bilateral lymph node drainage was synchronous in 38% (22/58) and asynchronous in 62% (in 18 patients the initial route was the left groin, and in the other 18, the right groin). Visualization before 30 min occurred in 66 patients (93%), in 64 of them (88%) already during the dynamic study. A total of 173 SNs were visualized (85 in the right groin, 88 in the left groin). Pitfalls were caused by inguinal skin contamination during injection (four patients) and intracavernous administration (one patient). At surgery, a total of 161 SNs were identified and removed. Sixteen patients (22%) had a tumour-positive SN and underwent standard regional lymph node dissection subsequently. During follow-up (median 28 months, range 3-74 months), two patients with a negative SN developed lymph node metastases in the mapped

  4. Sentinel Lymph Node Identification in Endometrial Cancer

    Institute of Scientific and Technical Information of China (English)

    Bin Li; Lingying Wu; Xiaoguang Li; Haizhen Lu; Ping Bai; Shumin Li; Wenhua Zhang; Juzhen Gao

    2009-01-01

    OBJECTIVE To evaluate the feasibility of intra-operative detection of sentinel lymph nodes (SLN) in the patient with endometrial cancer (EC).METHODS Thirty-one patients with Stage Ⅰ and Ⅱ endometrial cancer, who underwent a hysterectomy and a lymphadenectomy,were enrolled in the study. At laparotomy, methylene blue dye tracer was injected into the subserosal myometrium of corpus uteri at multiple sites, and dye uptake into the lymphatic channels was observed. The blue nodes which were identified as SLNs were traced and excised. The other nodes were then removed. All of the excised nodes were submitted for pathological hematoxylin and eosin (H&E) staining examination.RESULTS Failure of dye uptake occurred in 4 of the 31 cases (12.9%) because of spillage, and no lymphatic coloration was observed there. Lymphatic staining was clearly observable as blue dye diffused to the lymphatic channels of the uterine surface and the infundibulopelvic ligaments in 27 (87.1%) cases. Concurrent coloration in the pelvic lymphatic vessels was also observed in 22of the 27 patients. The SLNs were identified in 23 of the 27 (85.2%)cases with a lymphatic staining, with a total number of 90 SLNs,and a mean of 3.9 in each case (range, 1-10). Besides one SLN (1.1%)in the para-aortic area, the other 89 (98.9%) were in the nodes of the pelvis. The most dense locations of SLNs included obturator in 38 (42.2%) and interiliac in 19 (21.1%) cases. In our group, pelvic lymphadenectomy was conducted in 27 (87.1%) patients and pelvic nodal sampling in 4 (12.9%). Of the 31 cases, a concurrent abdominal para-aortic lymph node sampling was conducted in 7. A total of 926 nodes were harvested, with an average of 39.8 in each case (range, 14-55). Nodal metastases occurred in 3 patients (9.7%), 2 of them with SLN involvement and the other without SLN involvement. Adverse reactions or injury related to the study was not found.CONCLUSION Application of methylene blue dye is feasible in an intra

  5. Fixed-node errors in quantum Monte Carlo: interplay of electron density and node nonlinearities

    CERN Document Server

    Rasch, Kevin M; Mitas, Lubos

    2013-01-01

    We elucidate the origin of large differences (twofold or more) in valence fixed-node errors between the first- vs second-row atom systems for single-configuration trial wave functions. The differences are studied on a set of atoms, molecules, and Si, C solids. These systems are valence isoelectronic and have similar correlation energies, bond patterns, geometries, ground states, and symmetries. We show that the key reasons are the differences between the electron densities combined with the degree of node nonlinearities. The findings reveal how the accuracy of the quantum Monte Carlo varies across a variety of systems and provide new perspectives on the origins of the fixed-node biases.

  6. Metastases in small lymph nodes from colon cancer.

    Science.gov (United States)

    Herrera-Ornelas, L; Justiniano, J; Castillo, N; Petrelli, N J; Stulc, J P; Mittelman, A

    1987-11-01

    Lymph node metastases are important determinants in the prognosis of primary colorectal cancer. Although it has been established that enlarged, palpable lymph nodes contain metastases in less than half of the cases, no definitive data concerning the incidence of metastases in lymph nodes measuring 5 mm or less are available. We treated the surgical specimens of 52 consecutive patients who had colon cancer with a lymph node clearance technique at the Roswell Park Memorial Institute, Buffalo. We found 2699 lymph nodes in the 52 specimens, with a mean of 52 lymph nodes per specimen (range, five to 151). Sixty-four lymph nodes were found with metastases in 21 (40%) of the 52 patients. Fifty-nine of 64 of the lymph nodes were reexamined and remeasured. Thirty-nine lymph node metastases measured less than 5 mm, 13 were between 5 and 10 mm, and eight were larger than 10 mm. We concluded that lymph node metastases in colon cancer occur most frequently in lymph nodes measuring less than 5 mm (small lymph nodes). The use of lymph node clearing techniques in surgical specimens improves detection of small lymph node metastases and thereby diminishes understaging.

  7. Distributed Node-to-Node Consensus of Multiagent Systems with Delayed Nonlinear Dynamics and Intermittent Communications

    Directory of Open Access Journals (Sweden)

    Kexin Jia

    2015-01-01

    Full Text Available The paper is concerned with the problem of distributed node-to-node consensus of multiagent systems with delayed nonlinear dynamics and communication constraints. A new kind of consensus protocol based only on the intermittent measurements of neighboring agents is proposed to make each follower track the corresponding leader asymptotically. Based on the Lyapunov stability theory and M-matrix theory, some novel and simple criteria are derived for node-to-node consensus of multiagent systems. It is shown that consensus can be reached if the communication time duration is larger than the corresponding threshold value. Finally, a numerical example is provided to demonstrate the effectiveness of the obtained theoretical results.

  8. Utilities:Other:Fence Nodes, Pipe Spring National Monument, Arizona (Utilities.gdb:Other:Fence_Node)

    Data.gov (United States)

    National Park Service, Department of the Interior — This feature class contains points representing the nodes from the original "fence" coverage, which was converted to a line feature class. The "fence" feature class...

  9. Identifying Super-Spreader Nodes in Complex Networks

    Directory of Open Access Journals (Sweden)

    Yu-Hsiang Fu

    2015-01-01

    Full Text Available Identifying the most influential individuals spreading information or infectious diseases can assist or hinder information dissemination, product exposure, and contagious disease detection. Hub nodes, high betweenness nodes, high closeness nodes, and high k-shell nodes have been identified as good initial spreaders, but efforts to use node diversity within network structures to measure spreading ability are few. Here we describe a two-step framework that combines global diversity and local features to identify the most influential network nodes. Results from susceptible-infected-recovered epidemic simulations indicate that our proposed method performs well and stably in single initial spreader scenarios associated with various complex network datasets.

  10. Research on Critical Nodes Algorithm in Social Complex Networks

    Science.gov (United States)

    Wang, Xue-Guang

    2017-01-01

    Discovering critical nodes in social networks has many important applications and has attracted more and more institutions and scholars. How to determine the K critical nodes with the most influence in a social network is a NP (define) problem. Considering the widespread community structure, this paper presents an algorithm for discovering critical nodes based on two information diffusion models and obtains each node's marginal contribution by using a Monte-Carlo method in social networks. The solution of the critical nodes problem is the K nodes with the highest marginal contributions. The feasibility and effectiveness of our method have been verified on two synthetic datasets and four real datasets.

  11. Beginning Amazon Web Services with Node.js

    CERN Document Server

    Shackelford, Adam

    2015-01-01

    Beginning Amazon Web Services with Node.js teaches any novice Node.js developer to configure, deploy, and maintain scalable small to large scale Node.js applications in Amazon Web Services. Hosting a Node.js application in a production environment usually means turning to PaaS hosting, but this approach brings problems. Deploying Node.js directly to AWS solves the problems you encounter in these situations, enabling you to cut out the middle man. You will begin with a basic RESTful web service in Node.js, using the popular Express.js framework, pre-built and ready to run in your local env

  12. [Lymph node staging in gastrointestinal cancer. Combination of methylene blue-assisted lymph node dissection and ex vivo sentinel lymph node mapping].

    Science.gov (United States)

    Märkl, B; Arnholdt, H

    2012-11-01

    The histopathological lymph node staging is of crucial importance for the prognosis estimation and therapy stratification in gastrointestinal cancer. However, the recommended numbers of lymph nodes that should be evaluated are often not reached in routine practice. Methylene blue assisted lymph node dissection was introduced as a new, simple and efficient technique to improve lymph node harvest in gastrointestinal cancer. This method is inexpensive, causes no delay and needs no toxic substances. All studies performed revealed a highly significantly improved lymph node harvest in comparison to the conventional technique. Moreover, this technique can be combined with a new ex vivo sentinel lymph node mapping that for the first time is based on histological sentinel lymph node detection. The success rate of this method is similar to conventional techniques and it enables an efficient application of extended investigation methods, such as immunohistochemistry or the polymerase chain reaction.

  13. Sentinel node biopsy after neoadjuvant chemotherapy in cytologically proven node-positive breast cancer.

    Science.gov (United States)

    Yagata, Hiroshi; Yamauchi, Hideko; Tsugawa, Koichiro; Hayashi, Naoki; Yoshida, Atsushi; Kajiura, Yuka; In, Reika; Matsuda, Naoko; Nakamura, Seigo

    2013-12-01

    Several studies have assessed the feasibility of sentinel lymph node biopsy (SLNB) after NAC in patients with breast cancer, but diagnostic accuracy has varied. We prospectively evaluated the diagnostic accuracy of SLNB in detecting axillary lymph node (ALN) metastases after NAC in patients with cytologically proven positive nodes before chemotherapy. We studied 95 breast cancer patients with cytologically proven positive nodes and a partial or complete clinical response to NAC in the breast lesions confirmed using magnetic resonance imaging. Patients then underwent SLNB followed by ALN dissection. The identification rate of sentinel lymph nodes (SLNs) and the false negative rate of nodal metastases were assessed. Subgroup analysis was conducted according to several clinical factors. SLNs were successfully identified in 81 (85.3%) of the 95 patients. Among these 81 patients, 51 (63.0%) had ALN metastases on final pathologic examination after NAC. Eight of the 51 patients with ALN metastases had negative results on SLNB (false negative rate, 15.7%). Univariate analysis indicated that the false negative rate was significantly lower only in the HER2-negative group (P = .003). SLNB after NAC did not correctly predict the presence or absence of axillary node metastases in patients with breast cancer who had cytologically proven positive nodes before NAC. However, the diagnostic accuracy might be different in cancer subtypes, therapeutic effect of chemotherapy, or sentinel lymph node status after chemotherapy. Well-powered studies are needed to confirm diagnostic accuracy of SLNB after NAC according to subgroup in patients with breast cancer. Copyright © 2013 Elsevier Inc. All rights reserved.

  14. Immunohistochemical consistency between primary tumors and lymph node metastases of gastric neuroendocrine carcinoma

    Directory of Open Access Journals (Sweden)

    Uchiyama Chieko

    2012-06-01

    Full Text Available Abstract Background Gastric neuroendocrine carcinoma (G-NEC is a rare, highly malignant tumor that exhibits aggressive growth leading to vascular invasion, distant metastasis and extremely poor prognosis. We studied the clinicopathological findings of seven patients at our institute to better under this disease. Methods Seven cases of G-NEC were identified among 1,027 cases of gastric carcinoma that underwent gastrectomy at Kansai Rousai Hospital between 2002 and 2010. We studied the pathological and immunohistochemical features of gastric neuroendocrine carcinomas at both the primary site and metastatic lymph nodes. Results The mean patient age was 73 years (range 63 to 86 years. There were no females in this series. The final staging was Stage I in one case, Stage II in two, Stage III in two and Stage IV in two. A total of 31 metastatic lymph nodes were found in these patients. This study revealed that the ratio of neuroendocrine cells was similar between the primary and metastatic sites, which tended to show the same expression patterns of neuroendocrine markers. Conclusions Metastatic lymph nodes showed heterogeneous immunohistochemical expression patterns similar to the primary sites. G-NEC is far advanced at diagnosis and rapidly reaches the lymph nodes retaining its heterogeneity, carrying a worse prognosis than common gastric cancer. Mini abstract G-NEC grows rapidly and metastasizes to the lymph nodes, retaining its pathological and immunohistochemical heterogeneity even at the metastatic sites.

  15. Mobile Node Localization in Cellular Networks

    Directory of Open Access Journals (Sweden)

    Yasir Malik

    2012-01-01

    Full Text Available Location information is the major component in location based applications. This information is used in different safety and service oriented applications to provide users with services according to their Geolocation. There are many approaches to locate mobile nodes in indoor and outdoor environments. In thispaper, we are interested in outdoor localization particularly in cellular networks of mobile nodes andpresented a localization method based on cell and user location information. Our localization method is based on hello message delay (sending and receiving time and coordinate information of Base Transceiver Station (BTSs. To validate our method across cellular network, we implemented and simulated our method in two scenarios i.e. maintaining database of base stations in centralize and distributed system. Simulation results show the effectiveness of our approach and its implementation applicability in telecommunication systems.

  16. Measure of Node Similarity in Multilayer Networks

    CERN Document Server

    Mollgaard, Anders; Dammeyer, Jesper; Jensen, Mogens H; Lehmann, Sune; Mathiesen, Joachim

    2016-01-01

    The weight of links in a network is often related to the similarity of the nodes. Here, we introduce a simple tunable measure for analysing the similarity of nodes across different link weights. In particular, we use the measure to analyze homophily in a group of 659 freshman students at a large university. Our analysis is based on data obtained using smartphones equipped with custom data collection software, complemented by questionnaire-based data. The network of social contacts is represented as a weighted multilayer network constructed from different channels of telecommunication as well as data on face-to-face contacts. We find that even strongly connected individuals are not more similar with respect to basic personality traits than randomly chosen pairs of individuals. In contrast, several socio-demographics variables have a significant degree of similarity. We further observe that similarity might be present in one layer of the multilayer network and simultaneously be absent in the other layers. For a...

  17. Mobile node localization in cellular networks

    CERN Document Server

    Malik, Yasir; Abdulrazak, Bessam; Tariq, Usman; 10.5121/ijwmn.2011.3607

    2012-01-01

    Location information is the major component in location based applications. This information is used in different safety and service oriented applications to provide users with services according to their Geolocation. There are many approaches to locate mobile nodes in indoor and outdoor environments. In this paper, we are interested in outdoor localization particularly in cellular networks of mobile nodes and presented a localization method based on cell and user location information. Our localization method is based on hello message delay (sending and receiving time) and coordinate information of Base Transceiver Station (BTSs). To validate our method across cellular network, we implemented and simulated our method in two scenarios i.e. maintaining database of base stations in centralize and distributed system. Simulation results show the effectiveness of our approach and its implementation applicability in telecommunication systems.

  18. Modelling Traffic in IMS Network Nodes

    Directory of Open Access Journals (Sweden)

    BA Alassane

    2013-07-01

    Full Text Available IMS is well integrated with existing voice and data networks, while adopting many of their keycharacteristics.The Call Session Control Functions (CSCFs servers are the key part of the IMS structure. They are themain components responsible for processing and routing signalling messages.When CSCFs servers (P-CSCF, I-CSCF, S-CSCF are running on the same host, the SIP message can beinternally passed between SIP servers using a single operating system mechanism like a queue. It increasesthe reliability of the network [5], [6]. We have proposed in a last work for each type of service (between ICSCFand S-CSCF (call, data, multimedia.[23], to use less than two servers well dimensioned andrunning on the same operating system.Instead dimensioning servers, in order to increase performance, we try to model traffic on IMS nodes,particularly on entries nodes; it will provide results on separation of incoming flows, and then offer moresatisfactory service.

  19. Community Detection in Networks with Node Features

    CERN Document Server

    Zhang, Yuan; Zhu, Ji

    2015-01-01

    Many methods have been proposed for community detection in networks, but most of them do not take into account additional information on the nodes that is often available in practice. In this paper, we propose a new joint community detection criterion that uses both the network edge information and the node features to detect community structures. One advantage our method has over existing joint detection approaches is the flexibility of learning the impact of different features which may differ across communities. Another advantage is the flexibility of choosing the amount of influence the feature information has on communities. The method is asymptotically consistent under the block model with additional assumptions on the feature distributions, and performs well on simulated and real networks.

  20. Advanced technology nodes, a foundry perspective

    Science.gov (United States)

    Faul, Jürgen; Hoentschel, Jan; Wiatr, Maciej; Horstmann, Manfred

    2012-11-01

    Leading edge foundries need to fulfill a wide range of customer needs and have to deliver state-of-the-art performance processes. Therefore, an innovative but flexible modular technology set up is essential. This paper will show after a brief introduction of foundry challenges in general Global Foundries path towards the 28nm technology. Here, two key elements like high k metal gate process and embedded stressors are discussed. The article is concluded with an outlook on future device scaling from a leading edge foundry's perspective. This look ahead includes recent transistor architecture and process technology trends. More specifically, some challenges of the 20nm technology are discussed. This node will push planar transistor technology to its physical limits. Due to this, subsequent nodes will require substantial innovations in process architecture and device concepts. Two potential device paths are foreseen and compared, i.e. FinFet and ET-SOI-UTBB devices.

  1. Lymph node content of supraclavicular and thoracodorsal-based axillary flaps for vascularized lymph node transfer.

    Science.gov (United States)

    Gerety, Patrick A; Pannucci, Christopher J; Basta, Marten N; Wang, Amber R; Zhang, Paul; Mies, Carolyn; Kanchwala, Suhail K

    2016-01-01

    Microvascular transfer of lymph node flaps has recently gained popularity as a treatment for secondary lymphedema often occurring after axillary, groin, or pelvic lymph node dissections. This study aimed to delineate the lymph node contents and pedicle characteristics of the supraclavicular (SC) and thoracodorsal (TD)-based axillary flaps as well as to compare lymph node quantification of surgeon vs pathologist. SC and TD flaps were dissected from fresh female cadavers. The surgeon assessed pedicle characteristics, lymph node content, and anatomy. A pathologist assessed all flaps for gross and microscopic lymph node contents. The κ statistic was used to compare surgeon and pathologist. Ten SC flaps and 10 TD flaps were harvested and quantified. In comparing the SC and TD flaps, there were no statistical differences between artery diameter (3.1 vs 3.2 mm; P = .75) and vein diameter (2.8 vs 3.5 mm; P = .24). The TD flap did have a significantly longer pedicle than the SC flap (4.2 vs 3.2 cm; P = .03). The TD flap was found to be significantly heavier than the SC flap (17.0 ± 4.8 vs 12.9 ± 3.3 g; P = .04). Gross lymph node quantity was similar in the SC and TD flaps (2.5 ± 1.7 vs 1.8 ± 1.2; P = .33). There was good agreement between the surgeon and pathologist in detecting gross lymph nodes in the flaps (SC κ = 0.87, TD κ = 0.61). The SC and TD flaps have similar lymph node quantity, but the SC flap has higher lymphatic density. A surgeon's estimation of lymph node quantity is reliable and has been verified in this study by comparison to a pathologist's examination. Copyright © 2016 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

  2. [Genetic predictors of sick sinus node syndrome].

    Science.gov (United States)

    Chernova, A A; Nikulina, S Iu; Tret'iakova, S S

    2013-01-01

    The article is devoted to the role of heredity in development of the sick sinus node syndrome (SSNS). We have examined 14 probands and 110 their relatives from families with idiopathic SSNS and established the role in development of hereditary SSNS of polymorphisms of the following genes: -2-adrenoreceptor, enzyme endothelial NO synthase, protein connexin 40, voltage dependent cardiac sodium channels, cardiac myosin heavy chains. We also revealed associations of clinical variants of idiopathic SSNS with genotypes of the studied genes.

  3. Vulnerability of critical infrastructures : identifying critical nodes.

    Energy Technology Data Exchange (ETDEWEB)

    Cox, Roger Gary; Robinson, David Gerald

    2004-06-01

    The objective of this research was the development of tools and techniques for the identification of critical nodes within critical infrastructures. These are nodes that, if disrupted through natural events or terrorist action, would cause the most widespread, immediate damage. This research focuses on one particular element of the national infrastructure: the bulk power system. Through the identification of critical elements and the quantification of the consequences of their failure, site-specific vulnerability analyses can be focused at those locations where additional security measures could be effectively implemented. In particular, with appropriate sizing and placement within the grid, distributed generation in the form of regional power parks may reduce or even prevent the impact of widespread network power outages. Even without additional security measures, increased awareness of sensitive power grid locations can provide a basis for more effective national, state and local emergency planning. A number of methods for identifying critical nodes were investigated: small-world (or network theory), polyhedral dynamics, and an artificial intelligence-based search method - particle swarm optimization. PSO was found to be the only viable approach and was applied to a variety of industry accepted test networks to validate the ability of the approach to identify sets of critical nodes. The approach was coded in a software package called Buzzard and integrated with a traditional power flow code. A number of industry accepted test networks were employed to validate the approach. The techniques (and software) are not unique to power grid network, but could be applied to a variety of complex, interacting infrastructures.

  4. Popliteal lymph node metastasis of tibial osteoblastic osteosarcoma

    Directory of Open Access Journals (Sweden)

    Yalın Dirik

    2014-01-01

    CONCLUSION: Lymph node metastasis of osteosarcoma is a rare entity and metastatic patterns could not be clearly explained. On the other hand, the effects of lymph node metastasis on prognosis are also not clearly defined and further studies are needed.

  5. Fine-needle aspiration biopsy of lymph nodes

    African Journals Online (AJOL)

    2012-02-02

    Feb 2, 2012 ... Lymph nodes in the posterior cervical triangle and supraclavicular nodes are more suspicious for malignancy. ... exclusively primary or recurrent breast carcinoma in aspirates ... Lung carcinoma – small cell and non- small cell.

  6. Is Full Lymph Node Removal Always Needed for Melanoma?

    Science.gov (United States)

    ... Is Full Lymph Node Removal Always Needed for Melanoma? Survival was just as long for those who ... all lymph nodes in the vicinity of a melanoma skin cancer may not increase a patient's overall ...

  7. Node-Dependence-Based Dynamic Incentive Algorithm in Opportunistic Networks

    Directory of Open Access Journals (Sweden)

    Ruiyun Yu

    2014-01-01

    Full Text Available Opportunistic networks lack end-to-end paths between source nodes and destination nodes, so the communications are mainly carried out by the “store-carry-forward” strategy. Selfish behaviors of rejecting packet relay requests will severely worsen the network performance. Incentive is an efficient way to reduce selfish behaviors and hence improves the reliability and robustness of the networks. In this paper, we propose the node-dependence-based dynamic gaming incentive (NDI algorithm, which exploits the dynamic repeated gaming to motivate nodes relaying packets for other nodes. The NDI algorithm presents a mechanism of tolerating selfish behaviors of nodes. Reward and punishment methods are also designed based on the node dependence degree. Simulation results show that the NDI algorithm is effective in increasing the delivery ratio and decreasing average latency when there are a lot of selfish nodes in the opportunistic networks.

  8. Hadoop-Based Distributed Sensor Node Management System

    National Research Council Canada - National Science Library

    Jung, In-Yong; Kim, Ki-Hyun; Han, Byong-John; Jeong, Chang-Sung

    2014-01-01

    ... and retrieve sensor data periodically from DFS. Additionally, it provides a flexible management scheme for sensor node by reconfiguring firmware or updating configurations and data formats of sensor nodes based on mapreduce framework...

  9. Node Sensing & Dynamic Discovering Routes for Wireless Sensor Networks

    CERN Document Server

    Nanda, Arabinda; Rout, Saroj Kumar

    2010-01-01

    The applications of Wireless Sensor Networks (WSN) contain a wide variety of scenarios. In most of them, the network is composed of a significant number of nodes deployed in an extensive area in which not all nodes are directly connected. Then, the data exchange is supported by multihop communications. Routing protocols are in charge of discovering and maintaining the routes in the network. However, the correctness of a particular routing protocol mainly depends on the capabilities of the nodes and on the application requirements. This paper presents a dynamic discover routing method for communication between sensor nodes and a base station in WSN. This method tolerates failures of arbitrary individual nodes in the network (node failure) or a small part of the network (area failure). Each node in the network does only local routing preservation, needs to record only its neighbor nodes' information, and incurs no extra routing overhead during failure free periods. It dynamically discovers new routes when an in...

  10. Receiver-Controlled Multi-Node Cooperation

    Institute of Scientific and Technical Information of China (English)

    Liang Ye; Yue Li; XueJun Sha; Esko Alasaarela

    2014-01-01

    Since wireless links in Ad hoc networks are more fragile than those in traditional wireless networks due to route flapping, multi-node cooperation plays an important role in ensuring the quality of service ( QoS) . Based on the authors’ previous work, this paper proposes a receiver-controlled multi-node cooperation routing protocol, known as AODV-RCC. In this protocol, nodes form a cooperation group based on signal power. In a cooperation group, signal power between a partner and a transmitter, as well as signal power between the partner and the receiver, must be larger than the signal power between the transmitter and the receiver. Otherwise, the transmission will not benefit from cooperation. To avoid collision or congestion, each cooperation group only contains one partner. This partner offers both data and ACK cooperative retransmission. Its retransmission time should be shorter than the internal retry time of the transmitter’ s MAC layer, because it is better for the partner to retransmit firstly, as it offers a more reliable cooperative link. In AODV-RCC, it is the receiver that chooses the partner, because the link between the partner and the receiver is the most important. According to our simulation results, AODV-RCC shortens the end-to-end delay and increases the packet delivery ratio.

  11. Sarcoidal Granuloma in Cervical Lymph Nodes

    Directory of Open Access Journals (Sweden)

    Hsin-Chien Chen

    2005-07-01

    Full Text Available Sarcoidosis is a multiorgan granulomatous disease, the most common head and neck manifestation of which is cervical lymphadenopathy. Only the presentation of sarcoidal granuloma in cervical lymph nodes without typical manifestations of systemic sarcoidosis poses a diagnostic difficulty. We describe the case of a 39-year-old male who had a 2-month history of a progressively increasing mass with soreness in his right neck. The biopsy from the neck mass demonstrated non-caseating epithelioid cell granuloma of the lymph nodes. The differential diagnoses of mycobacterial or fungal infections were excluded. Thoracic evaluations, including chest X-ray and high-resolution computed tomography, revealed no abnormal findings. Treatment with systemic corticosteroids resulted in improved clinical symptoms. No recurrence of the neck mass or other signs of systemic sarcoidosis were noted during 1.5 years of follow-up. Although our patient's definitive diagnosis could not be determined, the case highlights 2 important issues: sarcoidal granuloma in lymph nodes may be a precursor of sarcoidosis, even in the absence of pulmonary or other systemic involvement; and regular follow-up is recommended in such cases.

  12. Simplified Dynamic Analysis of Grinders Spindle Node

    Science.gov (United States)

    Demec, Peter

    2014-12-01

    The contribution deals with the simplified dynamic analysis of surface grinding machine spindle node. Dynamic analysis is based on the use of the transfer matrix method, which is essentially a matrix form of method of initial parameters. The advantage of the described method, despite the seemingly complex mathematical apparatus, is primarily, that it does not require for solve the problem of costly commercial software using finite element method. All calculations can be made for example in MS Excel, which is advantageous especially in the initial stages of constructing of spindle node for the rapid assessment of the suitability its design. After detailing the entire structure of spindle node is then also necessary to perform the refined dynamic analysis in the environment of FEM, which it requires the necessary skills and experience and it is therefore economically difficult. This work was developed within grant project KEGA No. 023TUKE-4/2012 Creation of a comprehensive educational - teaching material for the article Production technique using a combination of traditional and modern information technology and e-learning.

  13. The Charles Perkins Centre's Twins Research Node.

    Science.gov (United States)

    Ferreira, Lucas C; Craig, Jeffrey M; Hopper, John L; Carrick, Susan E

    2016-08-01

    Twins can help researchers disentangle the roles of genes from those of the environment on human traits, health, and diseases. To realize this potential, the Australian Twin Registry (ATR), University of Melbourne, and the Charles Perkins Centre (CPC), University of Sydney, established a collaboration to form the Twins Research Node, a highly interconnected research facility dedicated specifically to research involving twins. This collaboration aims to foster the adoption of twin designs as important tools for research in a range of health-related domains. The CPC hosted their Twins Research Node's launch seminar entitled 'Double the power of your research with twin studies', in which experienced twin researchers described how twin studies are supporting scientific discoveries and careers. The launch also featured twin pairs who have actively participated in research through the ATR. Researchers at the CPC were surveyed before the event to gauge their level of understanding and interest in utilizing twin research. This article describes the new Twins Research Node, discusses the survey's main results and reports on the launch seminar.

  14. A case of lymphangioleiomyomatosis affecting the supraclavicular lymph nodes.

    Science.gov (United States)

    Kamitani, Takeshi; Yabuuchi, Hidetake; Soeda, Hiroyasu; Matsuo, Yoshio; Okafuji, Takashi; Sakai, Shuji; Hatakenaka, Masamitsu; Minami, Takahiro; Inoue, Hiromasa; Tanaka, Atsuo; Kohno, Hiroyuki; Tanaka, Michiko; Nakashima, Yutaka; Honda, Hiroshi

    2006-01-01

    The case of a 46-year-old woman with lymphangioleiomyomatosis (LAM) involving the supraclavicular, mediastinal, and pelvic lymph nodes in addition to the lungs is reported. Computed tomography incidentally revealed multiple thin-walled pulmonary cysts and low-attenuating masses in the supraclavicular, mediastinal, and retroperitoneal lymph nodes. A biopsy of the supraclavicular mass was performed and diagnosed as LAM histopathologically. The common sites of extrapulmonary LAM include retroperitoneal and mediastinal lymph nodes; however, supraclavicular lymph node involvement is extremely rare.

  15. Tumor-derived interleukin-1 promotes lymphangiogenesis and lymph node metastasis through M2-type macrophages.

    Directory of Open Access Journals (Sweden)

    Kosuke Watari

    Full Text Available Tumors formed by a highly metastatic human lung cancer cell line are characterized by activated signaling via vascular endothelial growth factor (VEGF-C through its receptor (VEGFR-3 and aggressive lymph node metastasis. In this study, we examined how these highly metastatic cancers acquired aggressive lymph node metastasis. Compared with their lower metastatic counterparts, the highly metastatic tumors formed by this cell line expressed higher amounts of interleukin (IL-1α, with similarly augmented expression of IL-1α and IL-1β by tumor stromal cells and of VEGF-A and VEGF-C by tumor-associated macrophages. These tumor-associated macrophages were mainly of the M2 type. Administration of a macrophage-targeting drug suppressed the production of these potent angiogenic and lymphangiogenic factors, resulting in decreased tumor growth, angiogenesis, lymphangiogenesis, and lymph node metastasis. In Matrigel plug assays, the highly metastatic cells formed tumors that were extensively infiltrated by M2-type macrophages and exhibited enhanced angiogenesis and lymphangiogenesis. All of these responses were suppressed by the IL-1 receptor (IL-1R antagonist anakinra. Thus, the IL-1α-driven inflammatory activation of angiogenesis and lymphangiogenesis seems to provide a highly metastatic tumor microenvironment favorable for lymph node metastasis through cross-talk with macrophages. Accordingly, the IL-1R/M2-type macrophage axis may be a good therapeutic target for patients with this form of lung cancer.

  16. Tumor-derived interleukin-1 promotes lymphangiogenesis and lymph node metastasis through M2-type macrophages.

    Science.gov (United States)

    Watari, Kosuke; Shibata, Tomohiro; Kawahara, Akihiko; Sata, Ken-ichi; Nabeshima, Hiroshi; Shinoda, Ai; Abe, Hideyuki; Azuma, Koichi; Murakami, Yuichi; Izumi, Hiroto; Takahashi, Takashi; Kage, Masayoshi; Kuwano, Michihiko; Ono, Mayumi

    2014-01-01

    Tumors formed by a highly metastatic human lung cancer cell line are characterized by activated signaling via vascular endothelial growth factor (VEGF)-C through its receptor (VEGFR-3) and aggressive lymph node metastasis. In this study, we examined how these highly metastatic cancers acquired aggressive lymph node metastasis. Compared with their lower metastatic counterparts, the highly metastatic tumors formed by this cell line expressed higher amounts of interleukin (IL)-1α, with similarly augmented expression of IL-1α and IL-1β by tumor stromal cells and of VEGF-A and VEGF-C by tumor-associated macrophages. These tumor-associated macrophages were mainly of the M2 type. Administration of a macrophage-targeting drug suppressed the production of these potent angiogenic and lymphangiogenic factors, resulting in decreased tumor growth, angiogenesis, lymphangiogenesis, and lymph node metastasis. In Matrigel plug assays, the highly metastatic cells formed tumors that were extensively infiltrated by M2-type macrophages and exhibited enhanced angiogenesis and lymphangiogenesis. All of these responses were suppressed by the IL-1 receptor (IL-1R) antagonist anakinra. Thus, the IL-1α-driven inflammatory activation of angiogenesis and lymphangiogenesis seems to provide a highly metastatic tumor microenvironment favorable for lymph node metastasis through cross-talk with macrophages. Accordingly, the IL-1R/M2-type macrophage axis may be a good therapeutic target for patients with this form of lung cancer.

  17. Sentinel lymph node concept in gastric cancer with solitary lymph node metastasis

    Institute of Scientific and Technical Information of China (English)

    Li-Yang Cheng; Shi-Zhen Zhong; Zong-Hai Huang

    2004-01-01

    AIM: To study the localization of the solitary metastases in relation to the primary gastric cancers and the feasibility of sentinel lymph node (SLN) concept in gastric cancer.METHODS: Eighty-six patients with gastric cancer, who had only one lymph node involved, were regarded retrospectively as patients with a possible sentinel node metastasis, and the distribution of these nodes were assessed. Thirteen cases with jumping metastases were further studied and followed up.RESULTS: The single nodal metastasis was found in the nearest perigastric nodal area in 65.1% (56/86) of the cases and in 19.8% (17/86) of the cases in a fairly remote perigastric area. Out of 19 middle-third gastric cancers,3 tumors at the lesser or greater curvatures had transverse metastases. There were also 15.1% (13/86) of patients with a jumping metastasis to N2-N3 nodes without N1 involved. Among them, the depth of invasion was mucosal (M) in 1 patient, submucosal (SM) in 2, proper-muscular (MP) in 4, subserosal (SS) in 5, and serosa-exposed (SE)in 1. Five of these patients died of gastric cancer recurrence at the time of this report within 3 years after surgery.CONCLUSION: These results suggest that nodal metastases occur in a random and multidirectional process in gastric cancer and that not every first metastatic node is located in the perigastric region near the primary tumor.The rate of "jumping metastasis" in gastric cancer is much higher than expected, which suggests that the blind examination of the nodal area close to the primary tumor can not be a reliable method to detect the SLN and that a extended lymph node dissection (ELND) should be performed if the preoperative examination indicates submucosal invasion.

  18. A longitudinal comparison of arm morbidity in stage I-II breast cancer patients treated with sentinel lymph node biopsy, sentinel lymph node biopsy followed by completion lymph node dissection, or axillary lymph node dissection

    NARCIS (Netherlands)

    Kootstra, Jan J.; Hoekstra-Weebers, Josette E.; Rietman, Johan S.; Vries, de Jakob; Baas, Peter C.; Geertzen, Jan H.B.; Hoekstra, Harald J.

    2010-01-01

    Background: Long-term shoulder and arm function following sentinel lymph node biopsy (SLNB) may surpass that following complete axillary lymph node dissection (CLND) or axillary lymph node dissection (ALND). We objectively examined the morbidity and compared outcomes after SLNB, SLNB + CLND, and ALN

  19. Sentinel node techniques in cancer of the vulva.

    Science.gov (United States)

    de Hullu, Joanne A; van der Zee, Ate G J

    2003-02-01

    The sentinel lymph node procedure, with the combined technique (preoperative lymphoscintigraphy with (99m)Technetium-labeled Nanocolloid and Patente Blue V ), is a promising staging technique for patients with vulvar cancer. The clinical implementation of the sentinel lymph node procedure and the role of additional histopathologic techniques of the sentinel lymph nodes are under investigation.

  20. Molecular markers of lymph node metastases in oral cancer

    NARCIS (Netherlands)

    Leusink, FKJ

    2017-01-01

    Cervical lymph node metastasis occurs frequently in patients with oral squamous-cell carcinoma (OSCC) and is a major determinant of prognosis and treatment planning. Accurate lymph node staging is therefore crucial. Current preoperative clinical assessment of the lymph nodes by physical examination

  1. Sentinel Node Mapping for Breast Cancer: Current Situation

    Directory of Open Access Journals (Sweden)

    Sergi Vidal-Sicart

    2012-01-01

    Full Text Available Axillary node status is a major prognostic factor in early-stage disease. Traditional staging needs levels I and II axillary lymph node dissection. Axillary involvement is found in 10%–30% of patients with T1 (<2 cm tumours. Sentinel lymph node biopsy is a minimal invasive method of checking the potential nodal involvement. It is based on the assumption of an orderly progression of lymph node invasion by metastatic cells from tumour site. Thus, when sentinel node is free of metastases the remaining nodes are free, too (with a false negative rate lesser than 5%. Moreover, Randomized trials demonstrated a marked reduction of complications associated with the sentinel lymph node biopsy when compared with axillary lymph node dissection. Currently, the sentinel node biopsy procedure is recognized as the standard treatment for stages I and II. In these stages, this approach has a positive node rate similar to those observed after lymphadenectomy, a significant decrease in morbidity and similar nodal relapse rates at 5 years. In this review, the indications and contraindications of the sentinel node biopsy are summarized and the methodological aspects discussed. Finally, the new technologic and histologic developments allow to develop a more accurate and refinate technique that can achieve virtually the identification of 100% of sentinel nodes and reduce the false negative rate.

  2. Identifying Vulnerable Nodes of Complex Networks in Cascading Failures Induced by Node-Based Attacks

    Directory of Open Access Journals (Sweden)

    Shudong Li

    2013-01-01

    Full Text Available In the research on network security, distinguishing the vulnerable components of networks is very important for protecting infrastructures systems. Here, we probe how to identify the vulnerable nodes of complex networks in cascading failures, which was ignored before. Concerned with random attack (RA and highest load attack (HL on nodes, we model cascading dynamics of complex networks. Then, we introduce four kinds of weighting methods to characterize the nodes of networks including Barabási-Albert scale-free networks (SF, Watts-Strogatz small-world networks (WS, Erdos-Renyi random networks (ER, and two real-world networks. The simulations show that, for SF networks under HL attack, the nodes with small value of the fourth kind of weight are the most vulnerable and the ones with small value of the third weight are also vulnerable. Also, the real-world autonomous system with power-law distribution verifies these findings. Moreover, for WS and ER networks under both RA and HL attack, when the nodes have low tolerant ability, the ones with small value of the fourth kind of weight are more vulnerable and also the ones with high degree are easier to break down. The results give us important theoretical basis for digging the potential safety loophole and making protection strategy.

  3. Sales Tax Collections in Nonmetropolitan Communities

    OpenAIRE

    Brorsen, B. Wade; Lansford, Notie H., Jr.

    2013-01-01

    Small communities sometimes increase their local sales tax rate in order to maintain or expand public services. The question addressed here is what is the net effect of changing sales tax rates on revenues from sales taxes? Using both semiparametric and nonparametric regression, we find retail sales to be mostly unaffected by sales tax rates as long as the rate is less than four percent. At rates higher than four percent, however, there is a severe reduction in sales, yet not enough that sale...

  4. A random network based, node attraction facilitated network evolution method

    Directory of Open Access Journals (Sweden)

    WenJun Zhang

    2016-03-01

    Full Text Available In present study, I present a method of network evolution that based on random network, and facilitated by node attraction. In this method, I assume that the initial network is a random network, or a given initial network. When a node is ready to connect, it tends to link to the node already owning the most connections, which coincides with the general rule (Barabasi and Albert, 1999 of node connecting. In addition, a node may randomly disconnect a connection i.e., the addition of connections in the network is accompanied by the pruning of some connections. The dynamics of network evolution is determined of the attraction factor Lamda of nodes, the probability of node connection, the probability of node disconnection, and the expected initial connectance. The attraction factor of nodes, the probability of node connection, and the probability of node disconnection are time and node varying. Various dynamics can be achieved by adjusting these parameters. Effects of simplified parameters on network evolution are analyzed. The changes of attraction factor Lamda can reflect various effects of the node degree on connection mechanism. Even the changes of Lamda only will generate various networks from the random to the complex. Therefore, the present algorithm can be treated as a general model for network evolution. Modeling results show that to generate a power-law type of network, the likelihood of a node attracting connections is dependent upon the power function of the node's degree with a higher-order power. Matlab codes for simplified version of the method are provided.

  5. Community Structure Detection Algorithm Based on the Node Belonging Degree

    Directory of Open Access Journals (Sweden)

    Jian Li

    2013-07-01

    Full Text Available In this paper, we propose a novel algorithm to identify communities in complex networks based on the node belonging degree. First, we give the concept of the node belonging degree, and then determine whether a node belongs to a community or not according to the belonging degree of the node with respect to the community. The experiment results of three real-world networks: a network with three communities with 19 nodes, Zachary Karate Club and network of American college football teams show that the proposed algorithm has satisfactory community structure detection.  

  6. A new miniaturized fiber positioning node for LAMOST

    Science.gov (United States)

    Guo, Liang; Gu, Yonggang; Shen, Yuran; Zhai, Chao

    2016-07-01

    To distribute more fiber positioning nodes on the LAMOST focal plate, two steps are proposed to miniaturize the fiber positioning node in this paper. The first step is to miniaturize the mechanical device of the fiber positioning node. The second step is to redesign the entire wireless driving board using smaller and performance-higher devices. As a result, the size of the new miniaturized fiber positioning node has to be reduced by above 40% and the dense of fiber positioning nodes on focal plate increases by 20% at least.

  7. Effects of node buffer and capacity on network traffic

    Institute of Scientific and Technical Information of China (English)

    Ling Xiang; Hu Mao-Bin; Ding Jian-Xun

    2012-01-01

    In this paper,we study the optimization of network traffic by considering the effects of node buffer ability and capacity.Two node buffer settings are considered.The node capacity is considered to be proportional to its buffer ability.The node effects on network traffic systems are studied with the shortest path protocol and an extension of the optimal routing [Phys.Rev.E 74 046106 (2006)].In the diagrams of flux-density relationships,it is shown that a nodes buffer ability and capacity have profound effects on the network traffic.

  8. Pattern of Colon Cancer Lymph Node Metastases in Patients Undergoing Central Mesocolic Lymph Node Excision

    DEFF Research Database (Denmark)

    Bertelsen, Claus A; Kirkegaard-Klitbo, Anders; Nielsen, Mingyuan

    2016-01-01

    not considered appropriate. The risk of central mesocolic lymph node metastases for right-sided cancers varies between 1% and 22%. In sigmoid cancer, the risk is reported in ≤12% of the patients and is associated with advanced T stage. LIMITATIONS: The retrospective design and heterogeneity, in terms...... of definitions of lymph node location, tumor sites, stage, morphology, pathology assessment, and inclusion criteria (selection bias), of the included studies were limitations. Also, anatomic definitions were not uniform. CONCLUSIONS: The present literature cannot give a theoretical explanation of a better...... oncological outcome after extended lymph node dissection. Consensus for a standardization of anatomical definitions and surgical and pathological assessments is warranted for future mapping studies....

  9. Enhancing Node Cooperation in Mobile Ad Hoc Network

    Directory of Open Access Journals (Sweden)

    S. Kami Makki

    2013-03-01

    Full Text Available Mobile Ad Hoc Networks (MANET have been a research interest over the past few years, yet, node cooperation has continually been a recognized issue for researchers. Because of their lack of infrastructure, MANETS depend on the cooperation of intermediate nodes in order to forward or send packets of their own to other nodes in the network. Therefore, nodes located in the central area of the network are used more frequently than the nodes located on the outer boundary. The inner nodes have to forward the packets of other nodes and if there is no payoff for forwarding the packets, the nodes may start to refrain from forwarding the packets of others to save their energy. The Community Enforcement Mechanism has been proposed to force the cooperation of among the nodes and reduce their misbehavior. Although, it provides cooperation among the nodes, it does not essentially increase the network life. In this paper, we present an efficient algorithm to improve the longevity of a MANET based upon more structured nodes cooperation.

  10. Ex vivo MRI of axillary lymph nodes in breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Luciani, Alain [Department of Radiology, AP-HP, Groupe Henri Mondor-Albert Chenevier, 94010 Creteil (France)], E-mail: luciani@hmn.ap-hop-paris.fr; Pigneur, Frederic [Department of Radiology, AP-HP, Groupe Henri Mondor-Albert Chenevier, 94010 Creteil (France); Ghozali, Faridah [Department of Pathology, AP-HP, Groupe Henri Mondor-Albert Chenevier, 94010 Creteil (France); Dao, Thu-Ha [Department of Radiology, AP-HP, Groupe Henri Mondor-Albert Chenevier, 94010 Creteil (France); Cunin, Patrick [Unite de Recherche Clinique, AP-HP, Groupe Henri Mondor-Albert Chenevier, 94010 Creteil (France); Meyblum, Evelyne [Department of Radiology, AP-HP, Groupe Henri Mondor-Albert Chenevier, 94010 Creteil (France); De Baecque-Fontaine, Cecile [Department of Pathology, AP-HP, Groupe Henri Mondor-Albert Chenevier, 94010 Creteil (France); Alamdari, Ali [Department of Plastic Surgery, AP-HP, Groupe Henri Mondor-Albert Chenevier, 94010 Creteil (France); Maison, Patrick [Unite de Recherche Clinique, AP-HP, Groupe Henri Mondor-Albert Chenevier, 94010 Creteil (France); Deux, Jean Francois [Department of Radiology, AP-HP, Groupe Henri Mondor-Albert Chenevier, 94010 Creteil (France); Lagrange, Jean Leon [Department of Radiotherapy, AP-HP, Groupe Henri Mondor-Albert Chenevier, 94010 Creteil (France); Lantieri, Laurent [Department of Plastic Surgery, AP-HP, Groupe Henri Mondor-Albert Chenevier, 94010 Creteil (France); Rahmouni, Alain [Department of Radiology, AP-HP, Groupe Henri Mondor-Albert Chenevier, 94010 Creteil (France)

    2009-01-15

    Purpose: To provide a strategy for precise co-localization of lymph nodes on axillary lymph-node dissection (ALND) specimens both on pathology and MR. To identify nodal features suggestive of metastatic involvement on a node-to-node basis. Materials and methods: National Institutional review-board approved this prospective study of 18 patients with breast cancer referred for ALND. Ex vivo T1 and inversion recovery (IR) T2 WI of ALND specimens tightly positioned within scaled plastic cranes was performed immediately after surgery. The correspondence of MR-based or pathologically based nodes location was assessed. The MR size and morphological presentation of metastatic and normal nodes were compared (Student's t-test or Mann-Whitney test). Quantitative variables were compared using Pearson coefficient. Results: 207 nodes were retrieved on pathology and 165 on MR. MR-pathological correlation of nodes location was high regarding MR-identified nodes (r = 0.755). An MR short axis threshold of 4 mm yielded the best predictive value for metastatic nodal involvement (Se = 78.6%; Sp = 62.3%). Irregular contours (Se = 35.7%; Sp = 96.7%), central nodal hyper-intensity on IR T2 WI (Se = 57.1%; Sp = 91.4%), and a cortical thickness above 3 mm (Se = 63.6%; Sp = 83.2%) were significantly associated with metastatic involvement. Conclusion: Ex vivo MR allows node-to-node correlation with pathology. Morphological MR criteria can suggest metastatic involvement.

  11. Sentinel node biopsy for melanoma: a study of 241 patients

    DEFF Research Database (Denmark)

    Chakera, Annette Hougaard; Drzewiecki, Krzysztof Tadeusz; Jakobsen, Annika Loft

    2004-01-01

    The aim of this study was to evaluate the sentinel node biopsy (SNB) technique for melanoma using both radiocolloid and blue dye in 241 clinically N0 patients with melanomas >1.0 mm, or thinner lesions exhibiting regression/ulceration. We showed that an increase in injected radioactivity increased...... both the number of visualized nodes at lymphoscintigraphy and the number of SNs removed surgically. At least one SN was removed in 98% (236) of patients, and all nodes were identified with the probe. Seventy-four per cent of the 194 patients injected with blue dye had stained SNs. In 46% (144......) of the lymph node basins, there was a discrepancy between the nodes visualized at lymphoscintigraphy and the nodes removed at surgery. There were 38 unusually located nodes. Only eight of these were removed surgically; none contained metastases. SN metastases were detected in 22% (53) of patients. There were...

  12. A Novel Mobile Sink Nodes Protocol for Grid Sensor Networks

    Directory of Open Access Journals (Sweden)

    Mei-Wen Huang

    2012-09-01

    Full Text Available The traditional wireless sensor networks (WSNs fixed the sink node in a certain place has a serious hotspot problem. The sensors closer to the sink node usually required forwarding a large amount of traffic for sensors farther from the sink node. Hotspot problem causes the nodes near the hotspot sensor node consuming much more energy than the other nodes, which seriously shortens the lifetime of the sensor networks. In the paper, it is proposed a dual mobile sink nodes protocol (DMSP which combines the balance traffic strategy in the WSNs to extend the lifetime of the sensor networks. The simulation results show that the proposed DMSP can efficiently prolong the lifetime of the WSNs.

  13. A Novel Technique Based on Node Registration in MANETs

    Directory of Open Access Journals (Sweden)

    Rashid Jalal Qureshi

    2012-09-01

    Full Text Available In ad hoc network communication links between the nodes are wireless and each node acts as a router for the other node and packet is forward from one node to other. This type of networks helps in solving challenges and problems that may arise in every day communication. Mobile Ad Hoc Networks is a new field of research and it is particularly useful in situations where network infrastructure is costly. Protecting MANETs from security threats is a challenging task because of the MANETs dynamic topology. Every node in a MANETs is independent and is free to move in any direction, therefore change its connections to other nodes frequently. Due to its decentralized nature different types of attacks can be occur. The aim of this research paper is to investigate different MANETs security attacks and proposed nodes registration based technique by using cryptography functions.

  14. Optical response of a line node semimetal

    Science.gov (United States)

    Carbotte, J. P.

    2017-02-01

    We calculate the AC optical response of a line node semimetal with emphasis on characteristic behaviours which can be used to distinguish them from point node materials such as Dirac and Weyl semimetals. The interband optical background at zero temperature displays a flat region at small photon energies ( Ω ) analogue to the universal background seen in graphene. However, in contrast to graphene, the height of the constant region is not universal but depends inversely on the Fermi velocity of the charge carriers and directly on the radius (b) in momentum space of the nodal circle. The parameter b is a defining energy scale and determines the range of photon energy over which the flat response persists. At high energies Ω >2b , the interband response becomes linear in Ω in agreement with the case for 3D-Dirac fermions with point node. The optical spectral weight contained in the interband or Drude conductivity shows the same two distinct regimes. At low temperature (T) (chemical potential (μ)), it rises linearly with T≤ft(μ \\right) and is proportional to b. At high temperature, T≤ft(μ \\right) , a {{T}2}≤ft({μ2}\\right) law is obtained, which is independent of b. At T  =  0, the Lorentz number takes on the conventional value {{L}o}={π2}/3{{e}2} for all values of μ. It increases with increasing temperature to reach a first plateau of 2.4L o provided T>μ but μ \\ll b . At high temperature, T  >  b, a second plateau of height 4.2L o emerges. The first plateau is characteristic of 2D-Dirac while the second corresponds to 3D-Dirac. The thermopower as a function of temperature also shows an evolution from a 2D to 3D behaviour.

  15. Sentinel node approach in prostate cancer.

    Science.gov (United States)

    Vidal-Sicart, S; Valdés Olmos, R A

    2015-01-01

    In general terms, one of the main objectives of sentinel lymph node (SLN) biopsy is to identify the 20-25% of patients with occult regional metastatic involvement. This technique reduces the associated morbidity from lymphadenectomy, as well as increasing the identification rate of occult lymphatic metastases by offering the pathologist those lymph nodes with the highest probability of containing metastatic cells. Pre-surgical lymphoscintigraphy is considered a "road map" to guide the surgeon towards the sentinel nodes and to ascertain unpredictable lymphatic drainages. In prostate cancer this aspect is essential due to the multidirectional character of the lymphatic drainage in the pelvis. In this context the inclusion of SPECT/CT should be mandatory in order to improve the SLN detection rate, to clarify the location when SLNs are difficult to interpret on planar images, to achieve a better definition of them in locations close to injection site, and to provide anatomical landmarks to be recognized during operation to locate SLNs. Conventional and laparoscopic hand-held gamma probes allow the SLN technique to be applied in any kind of surgery. The introduction and combination of new tracers and devices refines this technique, and the use of intraoperative images. These aspects become of vital importance due to the recent incorporation of robot-assisted procedures for SLN biopsy. In spite of these advances various aspects of SLN biopsy in prostate cancer patients still need to be discussed, and therefore their clinical application is not widely used. Copyright © 2015 Elsevier España, S.L.U. and SEMNIM. All rights reserved.

  16. A Multi-Purpose Modular Electronics Integration Node for Exploration Extravehicular Activity

    Science.gov (United States)

    Hodgson, Edward; Papale, William; Wichowski, Robert; Rosenbush, David; Hawes, Kevin; Stankiewicz, Tom

    2013-01-01

    As NASA works to develop an effective integrated portable life support system design for exploration Extravehicular activity (EVA), alternatives to the current system s electrical power and control architecture are needed to support new requirements for flexibility, maintainability, reliability, and reduced mass and volume. Experience with the current Extravehicular Mobility Unit (EMU) has demonstrated that the current architecture, based in a central power supply, monitoring and control unit, with dedicated analog wiring harness connections to active components in the system has a significant impact on system packaging and seriously constrains design flexibility in adapting to component obsolescence and changing system needs over time. An alternative architecture based in the use of a digital data bus offers possible wiring harness and system power savings, but risks significant penalties in component complexity and cost. A hybrid architecture that relies on a set of electronic and power interface nodes serving functional models within the Portable Life Support System (PLSS) is proposed to minimize both packaging and component level penalties. A common interface node hardware design can further reduce penalties by reducing the nonrecurring development costs, making miniaturization more practical, maximizing opportunities for maturation and reliability growth, providing enhanced fault tolerance, and providing stable design interfaces for system components and a central control. Adaptation to varying specific module requirements can be achieved with modest changes in firmware code within the module. A preliminary design effort has developed a common set of hardware interface requirements and functional capabilities for such a node based on anticipated modules comprising an exploration PLSS, and a prototype node has been designed assembled, programmed, and tested. One instance of such a node has been adapted to support testing the swingbed carbon dioxide and humidity

  17. Reverse Geographic Location of a Computer Node

    Science.gov (United States)

    2003-03-01

    2-9 2.3.4 Dijkstra’s Algorithm…………………………… 2-10 2.4 Location Tools.………………………………………….. 2-13 2.4.1 CAIDA Tools...way to its destination, such as the node names. 2.4.1 CAIDA Tools. “ CAIDA , the Cooperative Association for Internet Data Analysis, provides tools...and analyses promoting the engineering and maintenance of a robust, scalable global Internet infrastructure… CAIDA is a collaborative undertaking

  18. Energy Efficient Design for Body Sensor Nodes

    Directory of Open Access Journals (Sweden)

    Yanqing Zhang

    2011-04-01

    Full Text Available This paper describes the hardware requirements and design constraints that derive from unique features of body sensor networks (BSNs. Based on the BSN requirements, we examine the tradeoff between custom hardware and commercial off the shelf (COTS designs for BSNs. The broad range of BSN applications includes situations where either custom chips or COTS design is optimal. For both types of nodes, we survey key techniques to improve energy efficiency in BSNs and identify general approaches to energy efficiency in this space.

  19. Centrality of nodes in multiplex networks

    CERN Document Server

    Sola, Luis; Criado, Regino; Flores, Julio; del Amo, Alejandro Garcia; Boccaletti, Stefano

    2013-01-01

    We extend the concept of eigenvector centrality to multiplex networks, and introduce several alternative parameters that quantify the importance of nodes in a multi-layered networked system, including the de?nition of vectorial-type centralities. In addition we rigorously show that, under reasonable conditions, such centrality measures exist and are unique. Computer experiments and simulations demonstrate that the proposed measures provide substantially di?erent results when applied to the same multiplex structure, and highlight the non-trivial relationships between the di?erent measures of centrality introduced.

  20. Miniature Sensor Node with Conformal Phased Array

    Directory of Open Access Journals (Sweden)

    W. De Raedt

    2011-12-01

    Full Text Available This paper reports on the design and fabrication of a fully integrated antenna beam steering concept for wireless sensor nodes. The conformal array circumcises four cube faces with a silicon core mounted on each face. Every silicon core represents a 2 by 1 antenna array with an antenna element consisting of a dipole antenna, a balun, and a distributed MEMS phase shifter. All these components are based on a single wafer process and designed to work at 17.2 GHz. Simulations of the entire system and first results of individual devices are reported.

  1. Lymphangiogenesis and lymph node metastasis in breast cancer

    Directory of Open Access Journals (Sweden)

    Subramanian Ashok

    2008-03-01

    Full Text Available Abstract Introduction There have been few studies on lymphangiogenesis in the past due to the lack of specific lymphatic endothelial markers, and lymphatic-specific growth factors. Recently, these limitations have been relieved by the discovery of a small number of potential lymphatic-specific markers. The relationship between lymphangiogenesis and regional or distant metastasis has not previously been investigated in humans. Using these lymphatic markers, it is possible to explore the relationship between lymphangiogenesis and tumour metastasis. This study indirectly quantified lymphangiogenesis by measuring mRNA expression of all seven lymphatic markers described above in breast cancers and correlated these markers with lymphatic involvement and survival. The cDNA from 153 frozen archived breast samples were analysed with Q-PCR for all seven lymphangiogenic markers. This was correlated with various prognostic factors as well as patient survival. Results There was significantly greater expression of all 7 markers in malignant compared to benign breast tissue. In addition, there was greater expression in lymph node positive/grade 3 tumours when compared to lymph node negative/grade 1 tumours. In 5 of the markers, there was a greater expression in poor NPI prognostic tumours when compared to favourable prognostic tumours which was not statistically significant. There was no association between recurrence risk and lymphangiogenic marker expression. Conclusion In summary, the findings from this study show that lymphangiogenesis, measured by specific lymphatic marker expression, is higher in breast cancers than in normal breast tissue. Secondly, breast cancers which have metastasised to the regional lymphatics show higher expression compared to those which have not, although the individual differences for all five markers were not statistically significant.

  2. Ki-67 expression in axillary lymph node metastases in breast cancer is prognostically significant.

    Science.gov (United States)

    Tawfik, Kareem; Kimler, Bruce F; Davis, Marilyn K; Fan, Fang; Tawfik, Ossama

    2013-01-01

    Several studies have documented the prognostic significance of cell proliferation in breast cancer and its positive relationship with tumor grade, size, mitotic activity, hormonal and Her-2 status, and tumor progression. The Ki-67 antigen provides an accurate measure of the growth fraction of a tumor. Ki-67 expression in 103 primary breast carcinomas and their corresponding axillary lymph node metastases was correlated with age, tumor grade, size, estrogen receptor (ER), progesterone receptor (PgR), p53, epidermal growth factor receptor (EGFR), Bcl-2, Her-2 status, and patients' overall survival. Median Ki-67 expression in primary and metastatic tumors was 20% and 15%, respectively. Although there was no difference in overall survival (P = .65, log-rank test) between primary tumors with less than or at least 10% Ki-67 expression, there was significantly better overall survival when Ki-67 expression in lymph nodes was less than 10% (P = .040). For patients whose primary tumors exhibited Ki-67 expression less than 10%, most of their metastatic lesions had a similar low Ki-67; these patients had a favorable outcome. A small subgroup was noted to have a nodal Ki-67 of 10% or more and worse survival (P = .047). For patients whose primary tumors had a Ki-67 of 10% or more, most of their metastatic lesions had similar high Ki-67 values; however, a group of 12 patients had lymph node Ki-67 less than 10% and had a better overall survival (P = .092). Our results showed that measurement of Ki-67 in lymph node is superior to its evaluation in primary tumors. Identification of subgroups of patients in whom Ki-67 expression in lymph nodes differs from expression in primary tumor may assist in the selection of therapeutic options.

  3. [Lymph node preparation in colorectal cancer. Ex vivo methylene blue injection as a novel technique to improve lymph node visualization].

    Science.gov (United States)

    Märkl, B; Kerwel, T; Jähnig, H; Anthuber, M; Arnholdt, H

    2008-07-01

    The UICC requires investigation of a minimum of 12 lymph nodes for adequate lymph node staging in colorectal cancer. Despite that, many authors recommend investigation of a larger number, and different techniques, such as fat clearance, have therefore been developed. In this study we introduce a novel technique involving ex vivo lymph node staining with intraarterial methylene blue injection in colon cancer. We compared 14 cases in which methylene injection was used with 14 cases from our records in which conventional investigation techniques were applied. The lymph node harvest differed highly significantly (pmethylene blue group and the unstained group, respectively. The largest difference occurred in the size group 2-4 mm (191 vs 70 lymph nodes). In 6 cases in the unstained group additional embedding of fatty tissue was necessary to reach an adequate number of investigated lymph nodes. Methylene blue injection is a novel and highly effective method that will improve lymph node preparation in colorectal cancer.

  4. Weighted Radial Variation for Node Feature Classification

    CERN Document Server

    Andris, C

    2011-01-01

    Connections created from a node-edge matrix have been traditionally difficult to visualize and analyze because of the number of flows to be rendered in a limited feature or cartographic space. Because analyzing connectivity patterns is useful for understanding the complex dynamics of human and information flow that connect non-adjacent space, techniques that allow for visual data mining or static representations of system dynamics are a growing field of research. Here, we create a Weighted Radial Variation (WRV) technique to classify a set of nodes based on the configuration of their radially-emanating vector flows. Each entity's vector is syncopated in terms of cardinality, direction, length, and flow magnitude. The WRV process unravels each star-like entity's individual flow vectors on a 0-360{\\deg} spectrum, to form a unique signal whose distribution depends on the flow presence at each step around the entity, and is further characterized by flow distance and magnitude. The signals are processed with an un...

  5. Interactive Graph Layout of a Million Nodes

    Directory of Open Access Journals (Sweden)

    Peng Mi

    2016-12-01

    Full Text Available Sensemaking of large graphs, specifically those with millions of nodes, is a crucial task in many fields. Automatic graph layout algorithms, augmented with real-time human-in-the-loop interaction, can potentially support sensemaking of large graphs. However, designing interactive algorithms to achieve this is challenging. In this paper, we tackle the scalability problem of interactive layout of large graphs, and contribute a new GPU-based force-directed layout algorithm that exploits graph topology. This algorithm can interactively layout graphs with millions of nodes, and support real-time interaction to explore alternative graph layouts. Users can directly manipulate the layout of vertices in a force-directed fashion. The complexity of traditional repulsive force computation is reduced by approximating calculations based on the hierarchical structure of multi-level clustered graphs. We evaluate the algorithm performance, and demonstrate human-in-the-loop layout in two sensemaking case studies. Moreover, we summarize lessons learned for designing interactive large graph layout algorithms on the GPU.

  6. Clinical outcomes after sentinel lymph node biopsy in clinically node-negative breast cancer patients

    Energy Technology Data Exchange (ETDEWEB)

    Han, Hee Ji; Keun Ki Chang; Suh, Chang Ok; Kim, Yong Bae [Dept.of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul (Korea, Republic of); Kim, Ju Ree [Dept.of Radiation Oncology, Cheil General Hospital, Seoul (Korea, Republic of); Nam, Hee Rim [Dept.of Radiation Oncology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2014-09-15

    To evaluate non-sentinel lymph node (LN) status after sentinel lymph node biopsy (SNB) in patients with breast cancer and to identify the predictive factors for disease failure. From January 2006 to December 2007, axillary lymph node (ALN) dissection after SNB was performed for patients with primary invasive breast cancer who had no clinical evidence of LN metastasis. A total of 320 patients were treated with breast-conserving surgery and radiotherapy. The median age of patients was 48 years, and the median follow-up time was 72.8 months. Close resection margin (RM) was observed in 13 patients. The median number of dissected SNB was two, and that of total retrieved ALNs was 11. Sentinel node accuracy was 94.7%, and the overall false negative rate (FNR) was 5.3%. Eleven patients experienced treatment failure. Local recurrence, regional LN recurrence, and distant metastasis were identified in 0.9%, 1.9%, and 2.8% of these patients, respectively. Sentinel LN status were not associated with locoregional recurrence (p > 0.05). Close RM was the only significant factor for disease-free survival (DFS) in univariate and multivariate analysis. The 5-year overall survival, DFS, and locoregional DFS were 100%, 96.8%, and 98.1%, respectively. In this study, SNB was performed with high accuracy and low FNR and high locoregional control was achieved.

  7. Optimized lymph node staging in breast cancer in the era of sentinel node biopsy

    NARCIS (Netherlands)

    Madsen, E.V.E.

    2012-01-01

    SLNB has revolutionized staging and treatment in breast cancer patients, several issues provoked renewed attention. If small lymph node metastases are relevant, the pathologist should detect them. The current Dutch pathology guideline is not sensitive enough to detect them. To obtain a 95% detection

  8. Super Node Routing Strategy in Content-Centric Networking

    Institute of Scientific and Technical Information of China (English)

    苗春浇; 张宏科; 周华春; 董平; 沈烁

    2015-01-01

    There were two strategies for the data forwarding in the content-centric networking (CCN): forwarding strategy and routing strategy. Forwarding strategy only considered a separated node rather than the whole network performance, and Interest flooding led to the network overhead and redundancy as well. As for routing strategy in CCN, each node was required to run the protocol. It was a waste of routing cost and unfit for large-scale deployment. This paper presents the super node routing strategy in CCN. Some super nodes selected from the peer nodes in CCN were used to receive the routing information from their slave nodes and compute the face-to-path to establish forward-ing information base (FIB). Then FIB was sent to slave nodes to control and manage the slave nodes. The theoretical analysis showed that the super node routing strategy possessed robustness and scalability, achieved load balancing, reduced the redundancy and improved the network performance. In three topologies, three experiments were carried out to test the super node routing strategy. Network performance results showed that the proposed strategy had a shorter delay, lower CPU utilization and less redundancy compared with CCN.

  9. Data driven CAN node reliability assessment for manufacturing system

    Science.gov (United States)

    Zhang, Leiming; Yuan, Yong; Lei, Yong

    2017-01-01

    The reliability of the Controller Area Network(CAN) is critical to the performance and safety of the system. However, direct bus-off time assessment tools are lacking in practice due to inaccessibility of the node information and the complexity of the node interactions upon errors. In order to measure the mean time to bus-off(MTTB) of all the nodes, a novel data driven node bus-off time assessment method for CAN network is proposed by directly using network error information. First, the corresponding network error event sequence for each node is constructed using multiple-layer network error information. Then, the generalized zero inflated Poisson process(GZIP) model is established for each node based on the error event sequence. Finally, the stochastic model is constructed to predict the MTTB of the node. The accelerated case studies with different error injection rates are conducted on a laboratory network to demonstrate the proposed method, where the network errors are generated by a computer controlled error injection system. Experiment results show that the MTTB of nodes predicted by the proposed method agree well with observations in the case studies. The proposed data driven node time to bus-off assessment method for CAN networks can successfully predict the MTTB of nodes by directly using network error event data.

  10. Calculating Node Importance Considering Cascading Failure in Traffic Networks

    Directory of Open Access Journals (Sweden)

    Zhengwu Wang

    2013-01-01

    Full Text Available The traffic network is a scale-free network. In selective attack, invalidation of few key nodes may lead to network failure so it is important to find these key nodes. In this study, the key nodes are determined by establishing calculating methods of node importance based on cascading failure behaviors. First, a cascading failure model of traffic network is posed. Its differences from current models are as follows: 1 The upper travel network and lower road network are influenced each other, 2 Capacity of nodes and links are given at first but not in direct proportion to initial flow that is related to initial capacity, 3 Travel time is used to describe status of links, 4 Capacity of links may change. The evaluation method of node importance of traffic network considering cascading failure is proposed then based on node deletion. It uses congestion status of cascading failure network to describe the node importance and algorithm procedures are designed to estimate importance of all nodes. At the end, the experiment analysis shows that network structure and traveler behaviors have in significant influence on node importance.

  11. Chain-type wireless sensor network node scheduling strategy

    Institute of Scientific and Technical Information of China (English)

    Guangzhu Chen; Qingchun Meng; Lei Zhang

    2014-01-01

    In order to reduce power consumption of sensor nodes and extend network survival time in the wireless sensor network (WSN), sensor nodes are scheduled in an active or dormant mode. A chain-type WSN is fundamental y different from other types of WSNs, in which the sensor nodes are deployed along elongated geographic areas and form a chain-type network topo-logy structure. This paper investigates the node scheduling prob-lem in the chain-type WSN. Firstly, a node dormant scheduling mode is analyzed theoretical y from geographic coverage, and then three neighboring nodes scheduling criteria are proposed. Sec-ondly, a hybrid coverage scheduling algorithm and dead areas are presented. Final y, node scheduling in mine tunnel WSN with uniform deployment (UD), non-uniform deployment (NUD) and op-timal distribution point spacing (ODS) is simulated. The results show that the node scheduling with UD and NUD, especial y NUD, can effectively extend the network survival time. Therefore, a strat-egy of adding a few mobile nodes which activate the network in dead areas is proposed, which can further extend the network survival time by balancing the energy consumption of nodes.

  12. Video-assisted breast surgery can sample the second and third sentinel nodes to omit axillary node dissection for sentinel-node-positive patients.

    Science.gov (United States)

    Yamashita, K; Shimizu, K

    2009-07-01

    The preservation of the axillary node (AN) has become standard therapy for early breast cancer patients with a metastasis-positive sentinel node (SN). However, about half of the patients with metastasis in the SN have no metastasis in the other AN. Late-phase three-dimensional computed tomographic lymphography (3D-CT LG) of the breast can show the axillary lymphatic architecture from the SN into the venous angle. These nodes are classified into five groups. For the sake of aesthetics, video-assisted breast surgery (VABS) was used to sample the second and third nodes shown by 3D-CT LG. For marking the SN on the skin, 3D-CT LG was performed the day before the surgery. Iopamiron 300 (2 ml) was injected subcutaneously. A 16-channel multidetector-row helical CT image was reconstructed to produce a 3D image of the lymph ducts and nodes. A biopsy of the SN was performed by the dye-staining method using Visiport-aided endoscopy for VABS. Stained nodes were located by following the dye in the lymph ducts on a video monitor. For SN-metastasis-positive patients, standard AN dissection was performed under video assistance. Since July 2002, the authors have performed SN biopsy for 186 patients as well as 3D-CT LG and VABS SN biopsy for 146 patients. Five chained-node groups were shown. Even in the multiple SN case, the lymph ducts were converging into the second node. The second and third nodes beyond the SN were detected and sampled in 82 patients (56.2%) by VABS assisted with 3D-CT LG. Sentinel node metastasis (n = 40) involved SN metastasis alone in 21 cases (52.5%) and SN, second-node, and third-node metastasis in eight cases. A reviewed lymphoid path by 3D-CT LG confirmed that metastasis occurred in order of lymph flow. The use of 3D-CT LG-guided VABS SN biopsy of the second and third nodes will predict SN metastasis alone and help to obviate the need for dissection of more nodes.

  13. Preoperative diagnosis of lymph node metastasis in thoracic esophageal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Eguchi, Reiki; Yamada, Akiyoshi; Ueno, Keiko; Murata, Yoko [Tokyo Women`s Medical Coll. (Japan)

    1996-10-01

    From 1994 to 1995, to evaluate the utility of preoperative CT, EUS (endoscopic ultrasonography) and US in the diagnosis of lymph node metastasis in thoracic esophageal cancer, 94 patients with thoracic esophageal cancer who underwent esophagectomy were studied clinicopathologically. The sensitivity of EUS diagnosis of upper mediastinal lymph node metastasis (85%), left-sided paragastrin lymph node metastasis (73-77%), and especially lower paraesophageal lymph node metastasis (100%) were good. But due to their low-grade specificity in EUS diagnosis, their overall accuracy was not very good. On the other hand, the overall accuracy of the CT diagnosis of lymph node metastasis was fine. However, sensitivity, the most important clinical factor in the CT diagnosis of lymph node metastasis was considerably inferior to EUS. The assessment of the diagnosis of lymph node metastasis around the tracheal bifurcation and the pulmonary hilum and the left para-cardial lesion by CT or EUS was poor. It was concluded that lymph node metastasis of these area must be the pitfall in preoperative diagnosis. The average diameter of the lymph nodes and the proportion of cancerous tissue in the lymph nodes diagnosed as metastatic lymph nodes by CT was larger than that of the false negative lymph nodes. However, the lymph nodes diagnosed as true positives by EUS showed no such tendency. This must be the reason the sensitivity of the EUS diagnosis and specificity of the CT diagnosis were favorable, but the specificity of the EUS diagnosis and especially the sensitivity of the CT diagnosis were not as good. (author)

  14. [A case of breast cancer with postoperative metastasis to the supraclavicular lymph nodes-recurrence-free survival achieved by surgical excision following chemotherapy].

    Science.gov (United States)

    Tezuka, Kenji; Dan, Nobuhiro; Tendo, Masashige; Hori, Takeshi; Nishino, Hiroji

    2011-08-01

    The patient, a 58-year-old woman, underwent a partial excision of the right breast and an axillary lymph node dissection in October 2004. The histopathological findings were: solid tubular carcinoma with metastasis to 17 axillary lymph nodes; triple negative-type breast cancer. As adjuvant therapy, FEC60 was administered 6 times, followed by radiotherapy applied to the residual breast and the right supraclavicular fossa. In Novermber 2007, she noted a tumorous growth above the right clavicle. The pathological diagnosis via fine needle biopsy was adenocarcinoma. An oral antineoplastic agent was given for about 6 months, but did not alter the lymph nodes. No distant recurrence was noted during this time. In August 2008, the right supraclavicular lymph nodes were dissected. The patient has been under observation without treatment, but no signs of recurrence have been noted. It was thought that excision of the recurrent supra-clavicular lymph nodes should be considered after careful examination in some individual cases.

  15. The effect of trastuzumab-based chemotherapy in small node-negative HER2-positive breast cancer

    NARCIS (Netherlands)

    van Ramshorst, Mette S.; van der Heiden-van der Loo, Margriet; Dackus, Gwen M H E; Linn, Sabine C.; Sonke, Gabe S.

    The prognosis of patients with stage II–III Human Epidermal growth factor Receptor 2 (HER2)-positive breast cancer has significantly improved since the addition of trastuzumab to (neo-)adjuvant chemotherapy. Several reports have shown that small (≤2 cm), node-negative, HER2-positive tumors have a

  16. Retroperitoneal Lymph Node Dissection as First-Line Treatment of Node-Positive Seminoma.

    Science.gov (United States)

    Hu, Brian; Shah, Swar; Shojaei, Sepehr; Daneshmand, Siamak

    2015-08-01

    The long-term morbidity associated with treating advanced seminoma can be significant. Retroperitoneal lymph node dissection (RPLND) has established oncologic efficacy in treating germ cell tumors with minimal long-term toxicity. We describe our experience with RPLND as a front-line treatment of lymph node-positive seminoma. We reviewed our institutional review board-approved testicular cancer database to find the patients with pure seminoma and isolated retroperitoneal lymph node disease who had undergone primary RPLND. The clinical and pathologic variables were obtained. The follow-up data were used to determine recurrence and death. Four patients with a mean age of 37 years were identified. All patients had normal tumor markers and retroperitoneal lymphadenopathy measuring 1.1, 1.5, 1.8, and 5.5 cm before RPLND. Of the 4 patients, 3 had had seminoma diagnosed at orchiectomy and 1 (with a 5.5-cm retroperitoneal lymphadenopathy and a burned out primary testicular mass) had had seminoma diagnosed at RPLND after 2 nondiagnostic retroperitoneal biopsies. All patients had undergone nerve-sparing, template, extraperitoneal RPLND and were discharged home after 3 days. An average of 3 positive lymph nodes were found. Of the 4 patients, 3 had pathologic stage IIA and 1 stage IIB disease, with no patient undergoing adjuvant therapy. At a mean follow-up period of 25 months, no patient had experienced disease recurrence, and none had died. All patients maintained antegrade ejaculation, and no long-term complications had developed. Our small series has demonstrated encouraging oncologic efficacy for RPLND as a primary treatment of retroperitoneal lymph node-positive seminoma. A multi-institutional phase II trial of RPLND for stage IIA seminoma is being developed. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. Negative Expression of Melanoma Cell Adhesion Molecule (MCAM Correlated with Axillary Lymph Node Metastasis in Triple Negative Breast Cancer

    Directory of Open Access Journals (Sweden)

    Sartika Nurwenda

    2016-09-01

    Full Text Available Triple negative breast cancer (TNBC is breast cancer that demonstrate the absence of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2. TNBC has an aggressive behaviour, high frequency of metastasis to the axillary lymph nodes and recurrence, and poor prognosis. Metastasis to the axillary lymph nodes will affect the rate of survival and recurrence in TNBC. Melanoma cell adhession molecule (MCAM is a membrane glycoprotein of the immunoglobulin superfamily, which is involved in the cells binding, which later became known as the marker for the progression and metastasis of melanoma and carcinoma of the prostate. However, MCAM role in mammary carcinoma still controversial. The aim of this study was to assess correlation between MCAM expression with incidence of metastatic to axillary lymph nodes in TNBC. This research was conducted during January 1st 2010–April 31st 2015 at Pathology Anatomy, Faculty of Medicine, Universitas Padjadjaran. This study used a cross-sectional design, using lambda correlation test. MCAM immunohistochemical staining performed on 56 samples of paraffin blocks of TNBC group that did not metastasized and has metastasized to the axillary lymph nodes. A total of 22 of 28 (78.6% of TNBC metastatic to axillary lymph nodes have histoskor MCAM value <4 (negative, whereas 16 of 28 (57.1% of TNBC non-metastatic have histoskor value ≥ 4 (positive. Negative expression of MCAM correlated with TNBC that had metastasized to axillary lymph nodes, although not the only factor that influenced them.

  18. Macroscopic description of complex adaptive networks coevolving with dynamic node states

    Science.gov (United States)

    Wiedermann, Marc; Donges, Jonathan F.; Heitzig, Jobst; Lucht, Wolfgang; Kurths, Jürgen

    2015-05-01

    In many real-world complex systems, the time evolution of the network's structure and the dynamic state of its nodes are closely entangled. Here we study opinion formation and imitation on an adaptive complex network which is dependent on the individual dynamic state of each node and vice versa to model the coevolution of renewable resources with the dynamics of harvesting agents on a social network. The adaptive voter model is coupled to a set of identical logistic growth models and we mainly find that, in such systems, the rate of interactions between nodes as well as the adaptive rewiring probability are crucial parameters for controlling the sustainability of the system's equilibrium state. We derive a macroscopic description of the system in terms of ordinary differential equations which provides a general framework to model and quantify the influence of single node dynamics on the macroscopic state of the network. The thus obtained framework is applicable to many fields of study, such as epidemic spreading, opinion formation, or socioecological modeling.

  19. Efficient soybean regeneration and Agrobacterium-mediated transformation using a whole cotyledonary node as an explant.

    Science.gov (United States)

    Zhang, Fuli; Chen, Can; Ge, Honglian; Liu, Jinmei; Luo, Yunling; Liu, Kun; Chen, Long; Xu, Kedong; Zhang, Yi; Tan, Guangxuan; Li, Chengwei

    2014-01-01

    An optimized regeneration and Agrobacterium-mediated transformation protocol based on whole cotyledonary node explants was developed in soybean (Glycine max) cultivar Zhong Huang 13. Adding 6-benzylaminopurine (BAP) in a germinating medium could significantly increase regeneration efficiency; the optimal BAP concentration for shoot formation was 0.5 mg/L. The concentrations of plant growth regulators in a shoot induction medium were optimized by the orthogonal test [L9 (3(3))]. The best combination for shoot regeneration was a medium of Murashige & Skoog salts with B5 vitamins (MSB) supplemented with 3.5 mg/L BAP, 0.2 mg/L indole-3-butyric acid (IBA), and 0.2 mg/L kinetin (KT). Under this favorable condition, one node could regenerate 28-30 shoots. Soybean whole cotyledonary nodes were transformed by inoculation with A. tumefaciens strain EHA105 harboring a vector pBI121 containing a β-glucuronidase gene (gus). GUS assay, polymerase chain reaction, and Southern blot analysis indicated that the gus gene was transformed into soybean plants with 23.1% transformation efficiency. Transgenic plants could be obtained within 5-6 weeks, which was about 4 weeks less than that of a traditional single cotyledonary node method.

  20. Rapid identifying high-influence nodes in complex networks

    Institute of Scientific and Technical Information of China (English)

    宋波; 蒋国平; 宋玉蓉; 夏玲玲

    2015-01-01

    A tiny fraction of infl uential individuals play a critical role in the dynamics on complex systems. Identifying the infl uential nodes in complex networks has theoretical and practical significance. Considering the uncertainties of network scale and topology, and the timeliness of dynamic behaviors in real networks, we propose a rapid identifying method (RIM) to find the fraction of high-infl uential nodes. Instead of ranking all nodes, our method only aims at ranking a small number of nodes in network. We set the high-infl uential nodes as initial spreaders, and evaluate the performance of RIM by the susceptible–infected–recovered (SIR) model. The simulations show that in different networks, RIM performs well on rapid identifying high-infl uential nodes, which is verified by typical ranking methods, such as degree, closeness, betweenness, and eigenvector centrality methods.

  1. Sentinel lymph node biopsy and melanoma: 2010 update Part II.

    Science.gov (United States)

    Stebbins, William G; Garibyan, Lilit; Sober, Arthur J

    2010-05-01

    This article will discuss the evidence for and against the therapeutic efficacy of early removal of potentially affected lymph nodes, morbidity associated with sentinel lymph node biopsy and completion lymphadenectomy, current guidelines regarding patient selection for sentinel lymph node biopsy, and the remaining questions that ongoing clinical trials are attempting to answer. The Sunbelt Melanoma Trial and the Multicenter Selective Lymphadenectomy Trials I and II will be discussed in detail. At the completion of this learning activity, participants should be able to discuss the data regarding early surgical removal of lymph nodes and its effect on the overall survival of melanoma patients, be able to discuss the potential benefits and morbidity associated with complete lymph node dissection, and to summarize the ongoing trials aimed at addressing the question of therapeutic value of early surgical treatment of regional lymph nodes that may contain micrometastases. Copyright 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  2. DATA GATHERING IN WIRELESS SENSOR NETWORKS USING INTERMEDIATE NODES

    Directory of Open Access Journals (Sweden)

    Ahmad Ali Alhasanat

    2015-01-01

    Full Text Available Energy consumption is an essential concern to Wireless Sensor Networks (WSNs.The major cause of the energy consumption in WSNs is due to the data aggregation. A data aggregation is a process of collecting data from sensor nodes and transmitting these data to the sink node or base station. An effective way to perform such a task is accomplished by using clustering. In clustering, nodes are grouped into clusters where a number of nodes, called cluster heads, are responsible for gathering data from other nodes, aggregate them and transmit them to the Base Station (BS. In this paper we produce a new algorithm which focused on reducing the transmission bath between sensor nodes and cluster heads. A proper utilization and reserving of the available power resources is achieved with this technique compared to the well-known LEACH_C algorithm.

  3. Sentinel lymph nodes in cancer of the oral cavity

    DEFF Research Database (Denmark)

    Thomsen, Jørn Bo; Christensen, Rikke Kølby; Sørensen, Jens Ahm;

    2007-01-01

    BACKGROUND: Extended histopathologic work-up has increased the detection of micrometastasis in sentinel lymph nodes in malignant melanoma and breast cancer. The aim of this study was to examine if (A) step-sectioning of the central 1000 microM at 250 microM levels with immunostaining were accurate...... when compared with (B) step-sectioning and immunostaining of the entire sentinel lymph node at 250 microM levels. METHODS: Forty patients with T1/T2 cN0 oral cancer were enrolled. Three patients were excluded. In one patient no sentinel lymph node was identified. The remaining two had unidentified...... sentinel lymph nodes due to lymphoscintigraphic and surgical sampling error. The central 1000 microM of 147 sentinel lymph nodes were step-sectioned in 250-microm intervals and stained with hematoxylin and eosin and CK-KL1. All lymph nodes were recorded as negative or positive for macrometastases...

  4. Suppressing epidemics on networks by exploiting observer nodes

    CERN Document Server

    Takaguchi, Taro; Yoshida, Yuichi

    2013-01-01

    To control infection spreading on networks, we investigate the effect of observer nodes that recognize infection in a neighboring node, and make the rest of neighbor nodes immune. We numerically show that random placement of observer nodes works better on networks with clustering than on locally tree-like networks, implying that our model is promising for realistic social networks. The efficiency of several heuristic schemes for observer placement is also examined for synthetic and empirical networks. In parallel with numerical simulations of epidemic dynamics, we also show that the effect of observer placement can be assessed by the size of the largest connected component of networks remaining after removing observer nodes and links between their neighboring nodes.

  5. Identification of hybrid node and link communities in complex networks

    Science.gov (United States)

    He, Dongxiao; Jin, Di; Chen, Zheng; Zhang, Weixiong

    2015-03-01

    Identifying communities in complex networks is an effective means for analyzing complex systems, with applications in diverse areas such as social science, engineering, biology and medicine. Finding communities of nodes and finding communities of links are two popular schemes for network analysis. These schemes, however, have inherent drawbacks and are inadequate to capture complex organizational structures in real networks. We introduce a new scheme and an effective approach for identifying complex mixture structures of node and link communities, called hybrid node-link communities. A central piece of our approach is a probabilistic model that accommodates node, link and hybrid node-link communities. Our extensive experiments on various real-world networks, including a large protein-protein interaction network and a large network of semantically associated words, illustrated that the scheme for hybrid communities is superior in revealing network characteristics. Moreover, the new approach outperformed the existing methods for finding node or link communities separately.

  6. Regenerating a kidney in a lymph node.

    Science.gov (United States)

    Francipane, Maria Giovanna; Lagasse, Eric

    2016-10-01

    The ultimate treatment for end-stage renal disease (ESRD) is orthotopic transplantation. However, the demand for kidney transplantation far exceeds the number of available donor organs. While more than 100,000 Americans need a kidney, only 17,000 people receive a kidney transplant each year (National Kidney Foundation's estimations). In recent years, several regenerative medicine/tissue engineering approaches have been exploited to alleviate the kidney shortage crisis. Although these approaches have yielded promising results in experimental animal models, the kidney is a complex organ and translation into the clinical realm has been challenging to date. In this review, we will discuss cell therapy-based approaches for kidney regeneration and whole-kidney tissue engineering strategies, including our innovative approach to regenerate a functional kidney using the lymph node as an in vivo bioreactor.

  7. Multivariate polynomial interpolation on Lissajous-Chebyshev nodes

    OpenAIRE

    Dencker, Peter; Erb, Wolfgang

    2015-01-01

    In this article, we study multivariate polynomial interpolation and quadrature rules on non-tensor product node sets related to Lissajous curves and Chebyshev varieties. After classifying multivariate Lissajous curves and the interpolation nodes linked to these curves, we derive a discrete orthogonality structure on these node sets. Using this orthogonality structure, we obtain unique polynomial interpolation in appropriately defined spaces of multivariate Chebyshev polynomials. Our results g...

  8. Novel Node Structures for IP over WDM Networks

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    IP over WDM is being envisioned as one of the most attractive architectures for the next generation Internet. This paper introduces two novel backbone node structures for IP over WDM networks. These node structures can be used as improvement approaches to DPDP (default path and dedicated path) method. The flow classifiers, which are the main components of these node structures, and the performance metrics of these structures, are also discussed.

  9. Analysis of energy consumption nodes wireless sensor networks

    Directory of Open Access Journals (Sweden)

    Павел Викторович Галкин

    2014-09-01

    Full Text Available The article considers the issue of energy consumption and energy efficiency of the nodes of wireless sensor networks (WSN. It is revealed that the main factor influencing the increase in the probability of a malfunction of sensor networks is the limited resources of the power node. The methodology of calculation of energy consumption of nodes and the lifetime of the elements of their power.

  10. The Complex Network Synchronization via Chaos Control Nodes

    Directory of Open Access Journals (Sweden)

    Yin Li

    2013-01-01

    Full Text Available We investigate chaos control nodes of the complex network synchronization. The structure of the coupling functions between the connected nodes is obtained based on the chaos control method and Lyapunov stability theory. Moreover a complex network with nodes of the new unified Loren-Chen-Lü system, Coullet system, Chee-Lee system, and the New system is taken as an example; numerical simulations are used to verify the effectiveness of the method.

  11. Sentinel lymph node biopsy and melanoma: 2010 update Part I.

    Science.gov (United States)

    Stebbins, William G; Garibyan, Lilit; Sober, Arthur J

    2010-05-01

    Sentinel lymph node biopsy for melanoma was introduced in the early 1990s as a minimally invasive method of identifying and pathologically staging regional lymph node basins in patients with clinical stage I/II melanoma. Numerous large trials have demonstrated that sentinel lymph node evaluation has utility in improving accuracy of prognostication and for risk stratifying patients into appropriate groups for clinical trials. However, there remains a great deal of controversy regarding the therapeutic role of removal of the remainder of locoregional lymph nodes should metastatic cells be identified in the sentinel node. This CME article will outline a brief history of the sentinel node concept before reviewing updates in surgical technique, histopathologic evaluation of nodal tissue, and cost effectiveness of sentinel node biopsy. After completing this learning activity, participants should be able to describe the concept of sentinel lymph node biopsy, to discuss the risks and benefits associated with this procedure, and to summarize the role of sentinel lymph node biopsy in management of patients with melanoma. Copyright 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  12. Finding Important Nodes in Social Networks Based on Modified Pagerank

    Directory of Open Access Journals (Sweden)

    Li-qing Qiu

    2014-01-01

    Full Text Available Important nodes are individuals who have huge influence on social network. Finding important nodes in social networks is of great significance for research on the structure of the social networks. Based on the core idea of Pagerank, a new ranking method is proposed by considering the link similarity between the nodes. The key concept of the method is the use of the link vector which records the contact times between nodes. Then the link similarity is computed based on the vectors through the similarity function. The proposed method incorporates the link similarity into original Pagerank. The experiment results show that the proposed method can get better performance.

  13. Node.js ja reaaliaikainen viestintä

    OpenAIRE

    Skarp, Jani

    2015-01-01

    Insinöörityön tavoitteena oli luoda node.js-palvelinkehystä hyödyntävä reaaliaikainen keskusteluohjelma. Tavoitteena oli hyödyntää node.js:n nopeutta, mikä mahdollistaa reaaliaikaisten nettisovellusten luomisen. Tarkoituksena oli myös selvittää reaaliaikaisen viestinnän historiaa ja tarpeellisuutta ja miksi node.js soveltuu juuri reaaliaikaisten sovellusten tekemiseen. Luotu chat-ohjelma käyttää paljon hyödyksi node.js:n socket.io-moduulia. Socket.io antaa helpon tavan kommunikoida palvel...

  14. Maximizing Lifetime of Wireless Sensor Networks with Mobile Sink Nodes

    Directory of Open Access Journals (Sweden)

    Yourong Chen

    2014-01-01

    Full Text Available In order to maximize network lifetime and balance energy consumption when sink nodes can move, maximizing lifetime of wireless sensor networks with mobile sink nodes (MLMS is researched. The movement path selection method of sink nodes is proposed. Modified subtractive clustering method, k-means method, and nearest neighbor interpolation method are used to obtain the movement paths. The lifetime optimization model is established under flow constraint, energy consumption constraint, link transmission constraint, and other constraints. The model is solved from the perspective of static and mobile data gathering of sink nodes. Subgradient method is used to solve the lifetime optimization model when one sink node stays at one anchor location. Geometric method is used to evaluate the amount of gathering data when sink nodes are moving. Finally, all sensor nodes transmit data according to the optimal data transmission scheme. Sink nodes gather the data along the shortest movement paths. Simulation results show that MLMS can prolong network lifetime, balance node energy consumption, and reduce data gathering latency under appropriate parameters. Under certain conditions, it outperforms Ratio_w, TPGF, RCC, and GRND.

  15. Efficient Node Cooperation and Security in MANET using Closeness Technique

    Directory of Open Access Journals (Sweden)

    Sathiyakumar C.

    2014-05-01

    Full Text Available By description, a mobile ad hoc network does not stay on any permanent infrastructure; in its place, all networking utilities (e.g., routing, mobility management, etc. are accessed by the nodes themselves in a self-organizing manner. On the other hand, it is rigid to support cooperativeness among the nodes for their own restricted resources that require to be conserved. These scrupulous nodes which are also termed as selfish nodes decline to help other nodes in forwarding packets owing to the anxiety of having resource. Several researches design a new method that aims at attaining confidentiality of the location for an efficient communication. Thus, privacy appears from the mobile network and users gain control over the disclosure of their locations. In this work, we propose closeness mechanism accepted from the assumption of small-world event or also termed as degrees of separation to persuade cooperativeness among nodes in a trusted node’s community. This paper also provides some general idea on how to develop security on the trusted MANET community by adapting security features of trust. The simulation of the proposed Efficient Node Cooperation and Security [ENCS] in MANET work is done for varying topology, node size, attack type and intensity with different pause time settings and the performance evaluations are carried over in terms of node cooperativeness, clustering efficiency, communication overhead and compared with an existing secured key model.

  16. Implementation of bipartite or remote unitary gates with repeater nodes

    Science.gov (United States)

    Yu, Li; Nemoto, Kae

    2016-08-01

    We propose some protocols to implement various classes of bipartite unitary operations on two remote parties with the help of repeater nodes in-between. We also present a protocol to implement a single-qubit unitary with parameters determined by a remote party with the help of up to three repeater nodes. It is assumed that the neighboring nodes are connected by noisy photonic channels, and the local gates can be performed quite accurately, while the decoherence of memories is significant. A unitary is often a part of a larger computation or communication task in a quantum network, and to reduce the amount of decoherence in other systems of the network, we focus on the goal of saving the total time for implementing a unitary including the time for entanglement preparation. We review some previously studied protocols that implement bipartite unitaries using local operations and classical communication and prior shared entanglement, and apply them to the situation with repeater nodes without prior entanglement. We find that the protocols using piecewise entanglement between neighboring nodes often require less total time compared to preparing entanglement between the two end nodes first and then performing the previously known protocols. For a generic bipartite unitary, as the number of repeater nodes increases, the total time could approach the time cost for direct signal transfer from one end node to the other. We also prove some lower bounds of the total time when there are a small number of repeater nodes. The application to position-based cryptography is discussed.

  17. Sentinel lymph nodes in cancer of the oral cavity

    DEFF Research Database (Denmark)

    Thomsen, Jørn Bo; Sørensen, Jens Ahm; Krogdahl, Annelise

    2005-01-01

    BACKGROUND: Sentinel lymph node biopsy, step sectioning and immunohistochemistry have changed detection of tumour deposits. Isolated tumour cells (ITC) are detected more frequently than earlier because of a changed level of detection. METHODS: A total of 108 sentinel lymph nodes from 30 patients...... with T1/T2 cN0 oral cancer were re-classified histologically to find possible ITC and to describe technical pitfalls. RESULTS: Primarily we found metastatic spread in 12 of 108 sentinel lymph nodes: five macrometastasis and seven micrometastasis. After re-classification, we found seven lymph nodes...

  18. SpicyNodes: radial layout authoring for the general public.

    Science.gov (United States)

    Douma, Michael; Ligierko, Grzegorz; Ancuta, Ovidiu; Gritsai, Pavel; Liu, Sean

    2009-01-01

    Trees and graphs are relevant to many online tasks such as visualizing social networks, product catalogs, educational portals, digital libraries, the semantic web, concept maps and personalized information management. SpicyNodes is an information-visualization technology that builds upon existing research on radial tree layouts and graph structures. Users can browse a tree, clicking from node to node, as well as successively viewing a node, immediately related nodes and the path back to the "home" nodes. SpicyNodes' layout algorithms maintain balanced layouts using a hybrid mixture of a geometric layout (a succession of spanning radial trees) and force-directed layouts to minimize overlapping nodes, plus several other improvements over prior art. It provides XML-based API and GUI authoring tools. The goal of the SpicyNodes project is to implement familiar principles of radial maps and focus+context with an attractive and inviting look and feel in an open system that is accessible to virtually any Internet user.

  19. Is axillary lymph node dissection necessary after sentinel lymph node biopsy in patients with mastectomy and pathological N1 breast cancer?

    Science.gov (United States)

    Fu, Yun; Chung, Debra; Cao, Minh-An; Apple, Sophia; Chang, Helena

    2014-12-01

    The American College of Surgeons Oncology Group (ACOSOG) Z0011 trial reported that axillary lymph node dissection (ALND) did not change the recurrence and overall survival (OS) rates in patients with lumpectomy and one to two positive nodes detected by sentinel lymph node biopsy (SLNB). The aim of this study was to determine whether patients with mastectomy and pathological N1 disease found by SLNB could forego ALND. This is a retrospective study of 214 patients diagnosed with primary invasive breast cancer who were treated by mastectomy and lymph node staging surgery (SLNB or ALND) at the Revlon/UCLA Breast Center between January 2002 and December 2010. Patients with pathological N1 disease were separated by their first nodal surgery into SLNB (subgroups: observation, radiation, and additional ALND with or without radiation) and ALND groups (subgroups: ALND with or without radiation). After a median follow-up of 43.6 months, the OS and systemic relapse-free survival (RFS) rate of the radiation group and additional ALND group were significantly better than the observation group (p = 0.031 and 0.046, respectively). Human epidermal growth factor receptor 2 (HER2) expression was found to predict OS and patients' age, histological grade and HER2 expression predicted systemic recurrence. Compared with the SLNB group, pain (p = 0.021) and lymphedema (p = 0.043) occurred more frequently in the ALND group. Radiation was as effective as ALND in patients with mastectomy and N1 disease for OS and RFS rates, yet radiation after SLNB had fewer side effects than ALND. SLNB followed by radiation could replace ALND in patients with mastectomy and pathological N1 breast cancer identified by SLNB.

  20. Lymph node density predicts recurrence and death after inguinal lymph node dissection for penile cancer

    Science.gov (United States)

    Schwen, Zeyad R.; Ko, Joan S.; Meyer, Alexa; Netto, George J.; Burnett, Arthur L.; Bivalacqua, Trinity J.

    2017-01-01

    Purpose To determine the impact of lymph node density (LND) on survival after inguinal lymph node dissection (ILND) for penile cancer. Materials and Methods Our institutional penile cancer database was queried for patients who underwent ILND. Clinicopathologic characteristics including LND and total number of positive lymph nodes (LNs) were analyzed to determine impact on recurrence-free survival (RFS) and overall survival (OS). LND, or the percent of positive LN out of total LN, was calculated as a categorical variable at varying thresholds. Results Twenty-eight patients with complete follow-up were identified. Indications for ILND were stage >T2 in 20 patients (71.4%), palpable adenopathy in 7 (25%), high grade T1 in 1 (3.6%). Median node yield was 17.5 (interquartile range, 12−22), and positive LNs were found in 14 patients (50%). RFS and OS were significantly lower for patients with >15% LN density (median RFS: 62 months vs. 6.3 months, p=0.0120; median OS: 73.6 months vs. 6.3 months, p15% was independently associated with worse RFS (hazard ratio [HR], 3.6; p=0.04) and OS (HR, 73.6; p=0.002). The c-index for LND was higher than total positive LNs for RFS (0.64 vs. 0.54) and OS (0.79 vs. 0.61). Conclusions In this small, retrospective penile cancer cohort, the presence of nodal involvement >15% was associated with decreased RFS and OS, and outperformed total number of positive LN as a prognostic indicator.

  1. Prognostic factors in patients with node-negative gastric carcinoma: A comparison with node-positive gastric carcinoma

    Institute of Scientific and Technical Information of China (English)

    Dong Yi Kim; Kyeung Won Seo; Jae Kyoon Joo; Young Kyu Park; Seong Yeob Ryu; Hyeong Rok Kim; Young Jin Kim; Shin Kon Kim

    2006-01-01

    AIM: To identify the clinicopathological characteristics of lymph node-negative gastric carcinoma, and also to evaluate outcome indicators in the lymph node-negative patients.METHODS: Of 2848 gastric carcinoma patients, 1524(53.5%) were lymph node-negative. A statistical analysis was performed using the Cox model to estimate outcome indicators.RESULTS: There was a significant difference in the recurrence rate between lymph node-negative and lymph node-positive patients (14.4% vs 41.0%, P<0.001).The 5-year survival rate was significantly lower in lymph node-positive than in lymph node-negative patients (31.1% vs 77.4%, P<0.001). Univariate analysis revealed that the following factors influenced the 5-year survival rate: patient age, tumor size, depth of invasion,tumor location, operative type, and tumor stage at initial diagnosis. The Cox proportional hazard regression model revealed that tumor size, serosal invasion, and curability were independent, statistically significant, prognostic indicators of lymph node-negative gastric carcinoma.CONCLUSION: Lymph node-negative patients have a favorable outcome attributable to high curability, but the patients with relatively large tumors and serosal invasion have a poor prognosis. Curability is one of the most reliable predictors of long-term survival for lymph nodenegative gastric carcinoma patients.

  2. Mirror-image lymph node in FDG PET/CT and SPECT/CT for sentinel node detection.

    Science.gov (United States)

    Domenech, Beatriz; Paredes, Pilar; Rubí, Sebastià; Pahisa, Jaume; Vidal-Sicart, Sergi; Pons, Francesca

    2014-03-01

    We report a case of a patient with presumed stage IB1 squamous cell carcinoma of the cervix in which FDG PET/CT scan revealed 1 hypermetabolic left iliac node suggestive to be malignant. Lymphoscintigraphy and SPECT/CT studies previous to sentinel node (SLN) biopsy revealed unilateral drainage in the right pelvis. Intraoperative pathological assessment of the SLN showed no tumoral involvement, and the hypermetabolic node revealed macrometastasis. Tumor node invasion can lead to a lymphatic blockage and become false-negative for SLN technique. Although FDG PET/CT has lower sensitivity than surgical staging, this case shows its value as a preoperative imaging technique.

  3. Lymph node mapping with carbon nanoparticles and the risk factors of lymph node metastasis in gastric cancer.

    Science.gov (United States)

    Wang, Hui; Chen, Man-Man; Zhu, Guang-Sheng; Ma, Mao-Guang; Du, Han-Song; Long, Yue-Ping

    2016-12-01

    The study aimed to examine the applicability of carbon nanoparticles as a tracer for lymph node mapping and the related factors of lymph node and No.8p subgroup metastasis in patients with gastric cancer. Clinical data of 50 patients with gastric cancer, who had not received treatment preoperatively and underwent gastrectomy in Department of Gastrointestinal Surgery, Wuhan Union Hospital, between October 2014 and August 2015, were retrospectively analyzed. These patients were found to have no distant metastasis preoperatively. Thirty-five out of 50 patients were subjected to lymphatic mapping technique using carbon nanoparticles as the tracer, and the rest 15 cases did not experience the lymphatic mapping and served as controls. The sensitivity, specificity, false positive rate and false negative rate were calculated according to the number of lymph nodes, and the staining and metastasis condition of lymph nodes. The diagnostic value of carbon nanoparticles on metastatic lymph nodes was evaluated. The relationship between the metastasis of lymph nodes or subgroup No.8p lymph nodes and clinicopathologic features was analyzed by χ(2)-test or Fisher's exact test. All patients underwent D2 surgery (lymph node dissection including all the group 1 and group 2 nodes) plus the dissection of the subgroup No.8p lymph nodes. It was found that the average number of harvested lymph nodes in lymphatic mapping technique group (45.7±14.5) was greater than that in control group (39.2±11.7), but the difference was not significantly different (P=0.138>0.05). The success rate, the accuracy, sensitivity, specificity and false negative rate was 97%, 57%, 28%, 62% and 72% respectively. The metastasis of lymph nodes was correlated to the depth of cancer invasion (T stage) (P=0.004nanoparticles failed to show good selectivity for metastatic lymph nodes; the result of lymphatic mapping does not achieve a satisfactory performance; the incidence of lymph node metastasis may increase

  4. Prognostic impact of dissected lymph node count on patients with node-negative gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Chang-Ming Huang; Jian-Xian Lin; Chao-Hui Zheng; Ping Li; Jian-Wei Xie; Bi-Juan Lin; Hui-Shan Lu

    2009-01-01

    AIM: To investigate the long-term effect of the number of resected lymph nodes (LNs) on the prognosis of patients with node-negative gastric cancer. METHODS: Clinical data of 211 patients with gastric cancer, without nodal involvement, were analyzed retrospectively after D2 radical operation. We analyzed the relationship between the number of resected LNs with the 5-year survival, the recurrence rate and the post-operative complication rate.RESULTS: The 5-year survival of the entire cohort was 82.2%. The total number of dissected LNs was one of the independent prognostic factors. Among patients with comparable depth of invasion, the larger the number of resected LNs, the better the survival ( P 0.05).CONCLUSION: For node-negative gastric cancer,sufficient number of dissected LNs is recommended during D2 lymphadenectomy, to improve the long-term survival and reduce the recurrence. Suitable increments of the dissected LN count would not increase the postoperative complication rate.

  5. Number of Lymph Nodes Harvested From a Mediastinal Lymphadenectomy

    Science.gov (United States)

    Allen, Mark S.; Decker, Paul A.; Ballman, Karla; Malthaner, Richard A.; Inculet, Richard I.; Jones, David R.; McKenna, Robert J.; Landreneau, Rodney J.; Putnam, Joe B.

    2011-01-01

    Background: Lymph node status is a major determinant of stage and survival in patients with lung cancer; however, little information is available about the expected yield of a mediastinal lymphadenectomy. Methods: The American College of Surgeons Oncology Group Z0030 prospective, randomized trial of mediastinal lymph node sampling vs complete mediastinal lymphadenectomy during pulmonary resection enrolled 1,111 patients from July 1999 to February 2004. Data from 524 patients who underwent complete mediastinal lymph node dissection were analyzed to determine the number of lymph nodes obtained. Results: The median number of additional lymph nodes harvested from a mediastinal lymphadenectomy following systematic sampling was 18 with a range of one to 72 for right-sided tumors, and 18 with a range of four to 69 for left-sided tumors. The median number of N2 nodes harvested was 11 on the right and 12 on the left. A median of at least six nodes was harvested from at least three stations in 99% of patients, and 90% of patients had at least 10 nodes harvested from three stations. Overall, 21 patients (4%) were found to have occult N2 disease. Conclusions: Although high variability exists in the actual number of lymph nodes obtained from various nodal stations, complete mediastinal lymphadenectomy removes one or more lymph nodes from all mediastinal stations. Adequate mediastinal lymphadenectomy should include stations 2R, 4R, 7, 8, and 9 for right-sided cancers and stations 4L, 5, 6, 7, 8, and 9 for left-sided cancers. Six or more nodes were resected in 99% of patients in this study. Trial registry: ClinicalTrials.gov; No.: NCT00003831; URL: clinicaltrials.gov PMID:20829340

  6. Building scalable apps with Redis and Node.js

    CERN Document Server

    Johanan, Joshua

    2014-01-01

    If the phrase scalability sounds alien to you, then this is an ideal book for you. You will not need much Node.js experience as each framework is demonstrated in a way that requires no previous knowledge of the framework. You will be building scalable Node.js applications in no time! Knowledge of JavaScript is required.

  7. On Node Replication Attack in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Mumtaz Qabulio

    2016-04-01

    Full Text Available WSNs (Wireless Sensor Networks comprise a large number of small, inexpensive, low power and memory constrained sensing devices (called sensor nodes that are densely deployed to measure a given physical phenomenon. Since WSNs are commonly deployed in a hostile and unattended environment, it is easy for an adversary to physically capture one or more legitimate sensor nodes, re-program and redeploy them in the network. As a result, the adversary becomes able to deploy several identical copies of physically captured nodes in the network in order to perform illegitimate activities. This type of attack is referred to as Node Replication Attack or Clone Node Attack. By launching node replication attack, an adversary can easily get control on the network which consequently is the biggest threat to confidentiality, integrity and availability of data and services. Thus, detection and prevention of node replication attack in WSNs has become an active area of research and to date more than two dozen schemes have been proposed, which address this issue. In this paper, we present a comprehensive review, classification and comparative analysis of twenty five of these schemes which help to detect and/or prevent node replication attack in WSNs

  8. Long range node-strut analysis of trabecular bone microarchitecture

    DEFF Research Database (Denmark)

    Schmah, Tanya; Marwan, Norbert; Thomsen, Jesper Skovhus

    2011-01-01

    PURPOSE: We present a new morphometric measure of trabecular bone microarchitecture, called mean node strength (NdStr), which is part of a newly developed approach called long range node-strut analysis. Our general aim is to describe and quantify the apparent "latticelike" microarchitecture of th...

  9. [Sentinel lymph node biopsy in endometrial cancer - methods].

    Science.gov (United States)

    Yordanov, G; Gorchev, S; Tomov, N; Hinkova

    2014-01-01

    Endometrial canceris the most common gynaecological malignancy after brest cancer. The lymph node status is with great prognostic value and it is important for postoperative treatment and survival. That is why it is looking for methods giving information for the lymph node status and not increasing postoperative complications.

  10. Internal mammary sentinel lymph node biopsy: abandon or persist?

    Directory of Open Access Journals (Sweden)

    Qiu PF

    2016-06-01

    Full Text Available Peng-Fei Qiu, Yan-Bing Liu, Yong-Sheng Wang Breast Cancer Center, Shandong Cancer Hospital and Institute, Jinan, Shandong, People’s Republic of China Abstract: Although the 2009 American Joint Committee on Cancer incorporated the internal mammary sentinel lymph node biopsy (IM-SLNB concept, there has been little change in surgical practice patterns due to the low visualization rate of internal mammary sentinel lymph nodes with the traditional injection technique. Meanwhile, as internal mammary lymph nodes (IMLN metastases are mostly found concomitantly with axillary lymph nodes (ALN metastases, previous IM-SLNB clinical trials fail to evaluate the status of IMLN in patients who are really in need (only in clinically ALN negative patients. Our modified injection technique (periareolar intraparenchymal, high volume, and ultrasonographic guidance significantly improved the visualization rate of internal mammary sentinel lymph nodes, making the routine IM-SLNB possible in daily practice. IM-SLNB could provide individual minimally invasive staging, prognosis, and decision-making for breast cancer patients, especially for patients with clinically positive ALN. Moreover, IMLN radiotherapy should be tailored and balanced between the potential benefit and toxicity, and IM-SLNB-guided IMLN radiotherapy could achieve this goal. In the era of effective adjuvant therapy, within the changing treatment approach – more systemic therapy, less loco-regional therapy – clinicians should deliberate the application of regional IMLN therapy. Keywords: breast cancer, internal mammary lymph node, axillary lymph node, sentinel lymph node biopsy 

  11. Connectivity of Large Scale Networks: Distribution of Isolated Nodes

    CERN Document Server

    Mao, Guoqiang

    2011-01-01

    Connectivity is one of the most fundamental properties of wireless multi-hop networks. A network is said to be connected if there is a path between any pair of nodes. A convenient way to study the connectivity of a random network is by investigating the condition under which the network has no isolated node. The condition under which the network has no isolated node provides a necessary condition for a connected network. Further the condition for a network to have no isolated node and the condition for the network to be connected can often be shown to asymptotically converge to be the same as the number of nodes approaches infinity, given a suitably defined random network and connection model. Currently analytical results on the distribution of the number of isolated nodes only exist for the unit disk model. This study advances research in the area by providing the asymptotic distribution of the number of isolated nodes in random networks with nodes Poissonly distributed on a unit square under a generic rando...

  12. Is sodium current present in human sinoatrial node cells?

    NARCIS (Netherlands)

    Verkerk, A.O.; Wilders, R.; van Borren, M.M.G.J.; Tan, H.L.

    2009-01-01

    Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (I-Na) plays a role in the pacemaker activity of the human sinoatrial node. Recently, we had the unique opportu

  13. Virchow’s Node: A Look Beyond Gut Carcinoma

    Directory of Open Access Journals (Sweden)

    Bharath c

    2014-04-01

    Full Text Available Virchow’s node, left supraclavicular lymph node contains metastasis of many abdominal visceral malignancies. Urothelial carcinoma comprises 90% of all primary bladder tumors with metastases usually limited to the pelvic nodes. Though distant lymph node involvement is rare but cannot be entirely overlooked. Presence of Virchow’s node with bladder tumor is considered as incurable metastatic disease. A 40 year old male presented with history of fever, intermittent hematuria and burning micturition since one week. Incidentally left supraclavicular lymph node was found to be enlarged. FNAC showed the features of urothelial carcinoma. Patient was subjected to further relevant investigations. CT-Scan showed well defined enhancing lesion with intra-luminal extension. Biopsy was done which revealed primary tumor to be urothelial carcinoma of bladder. Supraclavicular lymph node metastases are rare in this case and indicate widespread disease with poor prognosis. Conclusion: This case is a rare presentation of urothelial carcinoma metastases to Virchow’s node. Picking up nodal metastases may influence therapeutic decisions and FNAC may be a useful tool in diagnosing such metastases with certainty.

  14. Radiation protection for the sentinel node procedure in breast cancer

    NARCIS (Netherlands)

    de Kanter, AY; Arends, PPAM; Eggermont, AMM; Wiggers, T

    2003-01-01

    Aims: The purpose of our study was to determine the radiation dose for those who are involved in the sentinel node procedure in breast cancer patients and testing of a theoretical model. Methods: We studied 12 consecutive breast cancer patients undergoing breast surgery, and a sentinel node dissecti

  15. [Nodes Dissections. What's up and what is at stake?].

    Science.gov (United States)

    Guillemin, François; Marchal, Frédéric

    2014-04-01

    Radical nodes dissection has a diagnostic value and can play a part in the treatment. Its interest could be questionable according to efficacy of the associated treatments either adjuvant or neo-adjuvant. Above all, sentinel node dissection allows to avoid a radical dissection with deleterious effects.

  16. Most frequent location of the sentinel lymph nodes

    Directory of Open Access Journals (Sweden)

    Chiao Lo

    2014-07-01

    Conclusion: The area between these four landmarks is the most frequent location of the sentinel lymph node identified using the radioisotope method. We suggest that this area should be carefully evaluated preoperatively by ultrasound for appropriate surgical planning. A skin incision in this area is also recommended when sentinel lymph node dissection is guided by blue dye.

  17. [Clinical physiology and physiopathology of the atrioventricular node].

    Science.gov (United States)

    Runge, M; Luckmann, E; Narula, O S

    1977-10-22

    The functional behaviour of the healthy and sick human AV-node under various clinical-experimental conditions is described with special reference to (1) AV-nodal conduction, (2) AV-nodel refractoriness, (3) influence of autonomic tone and (4) role of the AV-node in the initiation of rhythm disturbances.

  18. HISTOPATHOLOGICAL CHARACTERISTICS OF LYMPH NODE SINUS CONTAINING BLOOD

    Institute of Scientific and Technical Information of China (English)

    YIN Tong; JI Xiao-long

    2001-01-01

    This study is to find out the histopathological characteristics of lymph node sinus containing blood. Routine autopsy was carried out in the randomly selected 102 patients(among them,100 patients died of various diseases, and 2 of non-diseased causes),their superficial lymph nodes locating in the bilateral neck, axilla, inguina, thorax and abdomen were sampled. Haematoxylin-eosin staining was performed on 10% formalin-fixed and paraffin-embedded lymph node tissue sections(5μm).The histological characteristics of the lymph node sinuses containing blood were observed under light microscope. Among the 1362 lymph nodes sampled from the 100 autopsies, lymph sinuses containing blood were found in 809 lymph nodes sampled from 91 cases, but couldn't be seen in the lymph nodes sampled from the non-diseased cases. According to histology, five kinds of lymph sinuses containing blood were found:vascular-opening sinus, blood-deficient sinus, erythrophago-sinus, blood-abundant sinus, and vascular-formative sinus. It is concluded that in the state of disease, the phenomenon of blood in the lymph sinus is not uncommon. Blood could possibly enter into lymph sinus through lymphatic-venous communications between the veins and sinuses in the node. Lymph circulation and blood circulation could communicate with each other in the lymph sinus.

  19. The number of tumor-free axillary lymph nodes removed as a prognostic parameter for node-negative breast cancer

    Institute of Scientific and Technical Information of China (English)

    Fei Gao; Ni He; Pei-Hong Wu

    2014-01-01

    Recently, there has been controversy about the relationship between the number of lymph nodes removed and survival of patients diagnosed with lymph node-negative breast cancer. To assess this relationship, 603 cases of lymph node-negative breast cancer with a median of 126 months of follow-up data were studied. Patients were stratified into two groups (Group A, 10 or fewer tumor-free lymph nodes removed; Group B, more than 10 tumor-free lymph nodes removed). The number of tumor-free lymph nodes in ipsilateral axilary resections as wel as 5 other disease parameters were analyzed for prognostic value. Our results revealed that the risk of death from breast cancer was significantly associated with patient age, marital status, histologic grade, tumor size, and adjuvant therapy. The 5- and 10-year survival rates for patients with 10 or fewer tumor-free lymph nodes removed was 88.0% and 66.4%, respectively, compared with 69.2% and 51.1%, respectively, for patients with more than 10 tumor-free lymph nodes removed. For patients with 10 or fewer tumor-free lymph nodes removed, the adjusted hazard ratio (HR) for risk of death from breast cancer was 0.579 (95% confidence interval, 0.492-0.687,P < 0.001), independent of patient age, marital status, histologic grade, tumor size, and adjuvant therapy. Our study suggests that the number of tumor-free lymph nodes removed is an independent predictor in cases of lymph node-negative breast cancer.

  20. Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats.

    Science.gov (United States)

    Kaminskas, Lisa M; McLeod, Victoria M; Ascher, David B; Ryan, Gemma M; Jones, Seth; Haynes, John M; Trevaskis, Natalie L; Chan, Linda J; Sloan, Erica K; Finnin, Benjamin A; Williamson, Mark; Velkov, Tony; Williams, Elizabeth D; Kelly, Brian D; Owen, David J; Porter, Christopher J H

    2015-02-02

    The current study sought to explore whether the subcutaneous administration of lymph targeted dendrimers, conjugated with a model chemotherapeutic (methotrexate, MTX), was able to enhance anticancer activity against lymph node metastases. The lymphatic pharmacokinetics and antitumor activity of PEGylated polylysine dendrimers conjugated to MTX [D-MTX(OH)] via a tumor-labile hexapeptide linker was examined in rats and compared to a similar system where MTX was α-carboxyl O-tert-butylated [D-MTX(OtBu)]. The latter has previously been shown to exhibit longer plasma circulation times. D-MTX(OtBu) was well absorbed from the subcutaneous injection site via the lymph, and 3 to 4%/g of the dose was retained by sentinel lymph nodes. In contrast, D-MTX(OH) showed limited absorption from the subcutaneous injection site, but absorption was almost exclusively via the lymph. The retention of D-MTX(OH) by sentinel lymph nodes was also significantly elevated (approximately 30% dose/g). MTX alone was not absorbed into the lymph. All dendrimers displayed lower lymph node targeting after intravenous administration. Despite significant differences in the lymph node retention of D-MTX(OH) and D-MTX(OtBu) after subcutaneous and intravenous administration, the growth of lymph node metastases was similarly inhibited. In contrast, the administration of MTX alone did not significantly reduce lymph node tumor growth. Subcutaneous administration of drug-conjugated dendrimers therefore provides an opportunity to improve drug deposition in downstream tumor-burdened lymph nodes. In this case, however, increased lymph node biodistribution did not correlate well with antitumor activity, possibly suggesting constrained drug release at the site of action.

  1. Inhibition causes ceaseless dynamics in networks of excitable nodes

    Science.gov (United States)

    Larremore, Daniel B.; Shew, Woodrow L.; Ott, Edward; Sorrentino, Francesco; Restrepo, Juan G.

    2014-01-01

    The collective dynamics of a network of excitable nodes changes dramatically when inhibitory nodes are introduced. We consider inhibitory nodes which may be activated just like excitatory nodes but, upon activating, decrease the probability of activation of network neighbors. We show that, although the direct effect of inhibitory nodes is to decrease activity, the collective dynamics becomes self-sustaining. We explain this counterintuitive result by defining and analyzing a “branching function” which may be thought of as an activity-dependent branching ratio. The shape of the branching function implies that for a range of global coupling parameters dynamics are self-sustaining. Within the self-sustaining region of parameter space lies a critical line along which dynamics take the form of avalanches with universal scaling of size and duration, embedded in ceaseless timeseries of activity. Our analyses, confirmed by numerical simulation, suggest that inhibition may play a counterintuitive role in excitable networks. PMID:24745460

  2. Diffusion inspires selection of pinning nodes in pinning control

    Science.gov (United States)

    Zhou, Ming-Yang; He, Xingsheng; Fu, Zhong-Qian; Liao, Hao; Cai, Shi-min; Zhuo, Zhao

    2016-03-01

    The outstanding problem of controlling a complex network via pinning is related to network dynamics and has the potential to master large-scale real-world systems as well. This paper addresses the heart issue about how to choose pinning nodes for pinning control, where pinning control aims to control a network to an identical state by injecting feedback control signals to a small fraction of nodes. We explore networks' controllability from not only mathematical analysis, but also the aspects of network topology and information diffusion. Then, the connection between pinning control and information diffusion is given, and pinning node selection is transferred into multi-spreader problem in information diffusion. Based on information diffusion, a heuristic method is proposed to select pinning nodes by optimizing the spreading ability of multiple spreaders. The proposed method greatly improves the controllability of large practical networks, and provides a new perspective to investigate pinning node selection.

  3. Edge- and Node-Disjoint Paths in P Systems

    Directory of Open Access Journals (Sweden)

    Michael J. Dinneen

    2010-10-01

    Full Text Available In this paper, we continue our development of algorithms used for topological network discovery. We present native P system versions of two fundamental problems in graph theory: finding the maximum number of edge- and node-disjoint paths between a source node and target node. We start from the standard depth-first-search maximum flow algorithms, but our approach is totally distributed, when initially no structural information is available and each P system cell has to even learn its immediate neighbors. For the node-disjoint version, our P system rules are designed to enforce node weight capacities (of one, in addition to edge capacities (of one, which are not readily available in the standard network flow algorithms.

  4. Network expansion by adding arcs and/or nodes

    Institute of Scientific and Technical Information of China (English)

    YANG Xiaoguang; ZHANG Jianzhong

    2005-01-01

    In this paper, we consider a new network improvement model, which is to expand a network by adding new arcs and/or new nodes to satisfy the excess demand. For the new arcs and new nodes, there are constructing costs for. building these new facilities.The purpose of. our model is to minimize the total constructing cost. It is found that even if the constructing costs for all new nodes are zero or all new arcs are zero, solving the problem within an approximation ratio O(ln(|V1|+|V2|)) remains NP-hard, where V1 is the original node set, and V2 is thecandidate node set. We also present an MIP formulation for the problem and propose some heuristic ideas to solve the problem.

  5. Reentry confined to the atrioventricular node: electrophysiologic and anatomic findings.

    Science.gov (United States)

    Sheinman, M M; Gonzalez, R; Thomas, A; Ullyot, D; Bharati, S; Lev, M

    1982-05-01

    A patient with recurrent disabling, paroxysmal supraventricular tachycardia refractory to drug treatment underwent electrophysiologic studies. The paroxysmal supraventricular tachycardia was found to be due to atrioventricular (A-V) nodal reentry. The patient died shortly after surgical His bundle section and detailed anatomic studies were performed. These showed fatty infiltration of the approaches to the sinoatrial node, atrial preferential pathways, and A-V node and common bundle. The A-V node was mechanically damaged and the common His bundle was completely severed. These abnormalities were clearly delineated and there was no evidence of an atrio-His bundle bypass tract to an accessory A-V node. Specifically, the central fibrous body and pars membranacea were defined and no atrial muscular fibers pierced these structures to joint the A-V bundle. It is concluded that paroxysmal supraventricular tachycardia due to A-V nodal reentry can be confined to the A-V node.

  6. Effective number of accessed nodes in complex networks.

    Science.gov (United States)

    Viana, Matheus P; Batista, João L B; Costa, Luciano da F

    2012-03-01

    The measurement called accessibility has been proposed as a means to quantify the efficiency of the communication between nodes in complex networks. This article reports results regarding the properties of accessibility, including its relationship with the average minimal time to visit all nodes reachable after h steps along a random walk starting from a source, as well as the number of nodes that are visited after a finite period of time. We characterize the relationship between accessibility and the average number of walks required in order to visit all reachable nodes (the exploration time), conjecture that the maximum accessibility implies the minimal exploration time, and confirm the relationship between the accessibility values and the number of nodes visited after a basic time unit. The latter relationship is investigated with respect to three types of dynamics: traditional random walks, self-avoiding random walks, and preferential random walks.

  7. Automatic Network Fingerprinting through Single-Node Motifs

    CERN Document Server

    Echtermeyer, Christoph; Rodrigues, Francisco A; Kaiser, Marcus; 10.1371/journal.pone.0015765

    2011-01-01

    Complex networks have been characterised by their specific connectivity patterns (network motifs), but their building blocks can also be identified and described by node-motifs---a combination of local network features. One technique to identify single node-motifs has been presented by Costa et al. (L. D. F. Costa, F. A. Rodrigues, C. C. Hilgetag, and M. Kaiser, Europhys. Lett., 87, 1, 2009). Here, we first suggest improvements to the method including how its parameters can be determined automatically. Such automatic routines make high-throughput studies of many networks feasible. Second, the new routines are validated in different network-series. Third, we provide an example of how the method can be used to analyse network time-series. In conclusion, we provide a robust method for systematically discovering and classifying characteristic nodes of a network. In contrast to classical motif analysis, our approach can identify individual components (here: nodes) that are specific to a network. Such special nodes...

  8. Eradicating Catastrophic Collapse in Interdependent Networks via Reinforced Nodes

    CERN Document Server

    Yuan, Xin; Stanley, H Eugene; Havlin, Shlomo

    2016-01-01

    In interdependent networks, it is usually assumed, based on percolation theory, that nodes become nonfunctional if they lose connection to the network giant component. However, in reality, some nodes, equipped with alternative resources, together with their connected neighbors can still be functioning once disconnected from the giant component. Here we propose and study a generalized percolation model that introduces a fraction of reinforced nodes in the interdependent networks that can function and support their neighborhood. We analyze, both analytically and via simulations, the order parameter$-$the functioning component$-$comprising both the giant component and smaller components that include at least one reinforced node. Remarkably, we find that for interdependent networks, we need to reinforce only a small fraction of nodes to prevent abrupt catastrophic collapses. Moreover, we find that the universal upper bound of this fraction is 0.1756 for two interdependent Erd\\H{o}s-R\\'{e}nyi (ER) networks, regula...

  9. Pattern formation in oscillatory complex networks consisting of excitable nodes

    Science.gov (United States)

    Liao, Xuhong; Xia, Qinzhi; Qian, Yu; Zhang, Lisheng; Hu, Gang; Mi, Yuanyuan

    2011-05-01

    Oscillatory dynamics of complex networks has recently attracted great attention. In this paper we study pattern formation in oscillatory complex networks consisting of excitable nodes. We find that there exist a few center nodes and small skeletons for most oscillations. Complicated and seemingly random oscillatory patterns can be viewed as well-organized target waves propagating from center nodes along the shortest paths, and the shortest loops passing through both the center nodes and their driver nodes play the role of oscillation sources. Analyzing simple skeletons we are able to understand and predict various essential properties of the oscillations and effectively modulate the oscillations. These methods and results will give insights into pattern formation in complex networks and provide suggestive ideas for studying and controlling oscillations in neural networks.

  10. [Accumulation of tattoo pigment in sentinel lymph nodes].

    Science.gov (United States)

    Kürle, S; Schulte, K W; Homey, B

    2009-10-01

    A 22-year-old woman presented with a superficial spreading melanoma on her right thigh (tumor thickness 1.0 mm, Clark-Level III). She also had decorative tattoos on her right ankle, right groin and coccyx. The staging results gave no indication for metastases. Intra-operatively, we observed a black pigmented lymph node highly suspicious for metastatic disease, but histological examination excluded metastatic spread and detected the accumulation of black pigment within the lymph node. Clinical differentiation between tattoo pigments and metastatic disease within lymph nodes is not possible. Histological confirmation of an enlarged pigmented lymph node is therefore essential before radical surgery is performed. Hence, accumulation of tattoo pigment within enlarged and pigmented lymph nodes needs to be included into the differential diagnosis and the documentation of decorative tattoos is important during skin cancer screening as well as during the follow-up of melanoma patients.

  11. Lymphocyte migration into syngeneic implanted lymph nodes

    Energy Technology Data Exchange (ETDEWEB)

    Gordeeva, M.S.

    1986-03-01

    To judge the functional activity of lymphocytes of an implanted lymph node (LN), the proliferative response of lymphocytes of the implanted organ in the blast-transformation reaction in vitro and their ability to induce a local graft versus host reaction (GVHR) were determined. The lymphocyte suspension for labeling with /sup 51/Cr was obtained from peripheral LN in different situations from syngeneic mice. The resulting lymphocyte suspension was labeled with a solution of sodium chromate-/sup 51/Cr in a concentration of 20-40 microCi/100.10/sup 6/ cells in 1 ml for 40 min at 37/sup 0/C. The proliferative activity of a suspension of lymphocytes was estimated as incorporation of /sup 3/H-thymidine into DNA during incubation of the cell suspension for 3 days. Data on migration of /sup 51/Cr-labeled cells and the results of the morphological observations revealed marked ability of lymphocytes of the peripheral pool to colonize the regenerating stroma.

  12. Temporal node centrality in complex networks

    Science.gov (United States)

    Kim, Hyoungshick; Anderson, Ross

    2012-02-01

    Many networks are dynamic in that their topology changes rapidly—on the same time scale as the communications of interest between network nodes. Examples are the human contact networks involved in the transmission of disease, ad hoc radio networks between moving vehicles, and the transactions between principals in a market. While we have good models of static networks, so far these have been lacking for the dynamic case. In this paper we present a simple but powerful model, the time-ordered graph, which reduces a dynamic network to a static network with directed flows. This enables us to extend network properties such as vertex degree, closeness, and betweenness centrality metrics in a very natural way to the dynamic case. We then demonstrate how our model applies to a number of interesting edge cases, such as where the network connectivity depends on a small number of highly mobile vertices or edges, and show that our centrality definition allows us to track the evolution of connectivity. Finally we apply our model and techniques to two real-world dynamic graphs of human contact networks and then discuss the implication of temporal centrality metrics in the real world.

  13. LIGHT regulates inflamed draining lymph node hypertrophy

    Science.gov (United States)

    Zhu, Mingzhao; Yang, Yajun; Wang, Yugang; Wang, Zhongnan; Fu, Yang-Xin

    2011-01-01

    Lymph node (LN) hypertrophy, the increased cellularity of LNs, is the major indication of the initiation and expansion of the immune response against infection, vaccination, cancer or autoimmunity. The mechanisms underlying LN hypertrophy remain poorly defined. Here, we demonstrate that LIGHT (TNFSF14) is a novel factor essential for LN hypertrophy after CFA immunization. Mechanistically, LIGHT is required for the influx of lymphocytes into but not egress out of LNs. In addition, LIGHT is required for DC migration from the skin to draining LNs. Compared with WT mice, LIGHT−/− mice express lower levels of chemokines in skin and addressins in LN vascular endothelial cells after CFA immunization. We unexpectedly observed that LIGHT from radioresistant rather than radiosensitive cells, likely Langerhans cells, is required for LN hypertrophy. Importantly, antigen-specific T cell responses were impaired in DLN of LIGHT−/− mice, suggesting the importance of LIGHT regulation of LN hypertrophy in the generation of an adaptive immune response. Collectively, our data reveal a novel cellular and molecular mechanism for the regulation of LN hypertrophy and its potential impact on the generation of an optimal adaptive immune response. PMID:21572030

  14. Node-based analysis of species distributions

    DEFF Research Database (Denmark)

    Borregaard, Michael Krabbe; Rahbek, Carsten; Fjeldså, Jon;

    2014-01-01

    The integration of species distributions and evolutionary relationships is one of the most rapidly moving research fields today and has led to considerable advances in our understanding of the processes underlying biogeographical patterns. Here, we develop a set of metrics, the specific overrepre......The integration of species distributions and evolutionary relationships is one of the most rapidly moving research fields today and has led to considerable advances in our understanding of the processes underlying biogeographical patterns. Here, we develop a set of metrics, the specific...... with case studies on two groups with well-described biogeographical histories: a local-scale community data set of hummingbirds in the North Andes, and a large-scale data set of the distribution of all species of New World flycatchers. The node-based analysis of these two groups generates a set...... of intuitively interpretable patterns that are consistent with current biogeographical knowledge.Importantly, the results are statistically tractable, opening many possibilities for their use in analyses of evolutionary, historical and spatial patterns of species diversity. The method is implemented...

  15. Is Vocabulary Growth Influenced by the Relations among Words in a Language Learner's Vocabulary?

    Science.gov (United States)

    Sailor, Kevin M.

    2013-01-01

    Several recent studies have explored the applicability of the preferential attachment principle to account for vocabulary growth. According to this principle, network growth can be described by a process in which existing nodes recruit new nodes with a probability that is an increasing function of their connectivity within the existing network.…

  16. Generalization of FEM Using Node-Based Shape Functions

    Directory of Open Access Journals (Sweden)

    Kanok-Nukulchai W.

    2015-12-01

    Full Text Available In standard FEM, the stiffness of an element is exclusively influenced by nodes associated with the element via its element-based shape functions. In this paper, the authors present a method that can be viewed as a generalization of FEM for which the influence of a node is not limited by a hat function around the node. Shape functions over an element can be interpolated over a predefined set of nodes around the element. These node-based shape functions employ Kriging Interpolations commonly found in geostatistical technique. In this study, a set of influencing nodes are covered by surrounding layers of elements defined as its domain of influence (DOI. Thus, the element stiffness is influenced by not only the element nodes, but also satellite nodes outside the element. In a special case with zero satellite nodes, the method is specialized to the conventional FEM. This method is referred to as Node-Based Kriging FEM or K-FEM. The K-FEM has been tested on 2D elastostatic, Reissner-Mindlin’s plate and shell problems. In all cases, exceptionally accurate displacement and stress fields can be achieved with relatively coarse meshes. In addition, the same set of Kringing shape functions can be used to interpolate the mesh geometry. This property is very useful for representing the curved geometry of shells. The distinctive advantage of the K-FEM is its inheritance of the computational procedure of FEM. Any existing FE code can be easily extended to K-FEM; thus, it has a higher chance to be accepted in practice.

  17. A moat around castle walls. The role of axillary and facial hair in lymph node protection from mutagenic factors.

    Science.gov (United States)

    Komarova, Svetlana V

    2006-01-01

    Axillary hair is a highly conserved phenotypical feature in humans, and as such deserves at least consideration of its functional significance. Protection from environmental factors is one of the main functions attributed to hair in furred vertebrates, but is believed to be inapplicable to humans. I considered the hypothesis that the phenotypic preservation of axillary hair is due to its unrecognized role in the organism protection. Two immediate questions arise--what exactly is being protected and what it is protected from. A large group of axillary lymph nodes represents a major difference between underarms and the adjacent areas of the trunk. The consideration of potential factors from which hair can offer protection identifies sunlight as the most likely candidate. Intense sweat production underarms may represent an independent defense mechanism, specifically protecting lymph nodes from overheating. Moreover, the pattern of facial hair growth in males strikingly overlaps with the distribution of superficial lymph nodes, suggesting potential role for facial hair in protection of lymph nodes, and possibly thymus and thyroid. The idea of lymph node protection from environmental mutagenic factors, such as UV radiation and heat, appears particularly important in light of wide association of lymph nodes with cancers. The position of contemporary fashion towards body hair is aggressively negative, including the social pressure for removal of axillary and bikini line hair for women, facial hair for men in many professional occupations, and even body hair for men. If this hypothesis is proven to be true, the implications will be significant for immunology (by providing new insights in lymph node physiology), health sciences (depilation is painful and therefore easily modifiable habit if proven to increase disease risk), as well as art, social fashion and economy.

  18. Enhanced Intrusion Detection System for Malicious Node Detection in Mobile Ad hoc Networks using Data Transmission Quality of Nodes

    Directory of Open Access Journals (Sweden)

    S. Mamatha

    2014-09-01

    Full Text Available Mobile Ad hoc NETworks (MANETs are the new generation of networks that offer unrestricted mobility without any underlying infrastructure. It relies on the cooperation of all the participating nodes. Due to their open nature and lack of infrastructure, security for MANETS has become an intricate problem than the security in other networks. The conventional security mechanisms of protecting a wired network are not sufficient for these networks. Hence a second level of defense to detect and respond to the security problem called an Intrusion detection system is required. Generally the malicious nodes demonstrate a different behavioral pattern of all the other normal nodes. So an Intrusion Detection System based on anomaly based intrusion detection that works by checking the behavior of the nodes was proposed. Here, in this paper to determine the behavior of the nodes as malicious or legitimate a Data Transmission Quality (DTQ function is used. The DTQ function is defined in such a way that it will be close to a constant or keep changing smoothly for genuine nodes and will keep on diminishing for malicious nodes.. The final decision of confirming nodes as malicious is determined by a group consensus method. The evaluation results show that the proposed method increases the detection rate as well as decreases the false positive rate.

  19. Sentinel lymph node biopsy in node-negative squamous cell carcinoma of the oral cavity and oropharynx.

    LENUS (Irish Health Repository)

    Burns, P

    2012-02-01

    OBJECTIVES: Considerable controversy exists regarding the merits of elective neck dissection in patients with early stage oral cavity and oropharyngeal squamous cell carcinoma. It is highly desirable to have a method of identifying those patients who would benefit from further treatment of the neck when they are clinically node-negative. The purpose of the present study was to examine the use of sentinel lymph node biopsy in identifying occult neck disease in a cohort of patients with node-negative oral cavity and oropharyngeal squamous cell carcinoma. DESIGN: We evaluated a total of 13 patients with oral cavity and oropharyngeal cancer who were clinically and radiologically node-negative. RESULTS: A sentinel lymph node was found in all 13 patients, revealing metastatic disease in five patients, four of whom had one or more positive sentinel lymph nodes. There was one false negative result, in which the sentinel lymph node was negative for tumour whereas histological examination of the neck dissection specimen showed occult disease. CONCLUSION: In view of these findings, we would recommend the use of sentinel lymph node biopsy in cases of oral cavity and oropharyngeal squamous cell carcinoma, in order to aid the differentiation of those patients whose necks are harbouring occult disease and who require further treatment.

  20. Distributing an executable job load file to compute nodes in a parallel computer

    Science.gov (United States)

    Gooding, Thomas M.

    2016-08-09

    Distributing an executable job load file to compute nodes in a parallel computer, the parallel computer comprising a plurality of compute nodes, including: determining, by a compute node in the parallel computer, whether the compute node is participating in a job; determining, by the compute node in the parallel computer, whether a descendant compute node is participating in the job; responsive to determining that the compute node is participating in the job or that the descendant compute node is participating in the job, communicating, by the compute node to a parent compute node, an identification of a data communications link over which the compute node receives data from the parent compute node; constructing a class route for the job, wherein the class route identifies all compute nodes participating in the job; and broadcasting the executable load file for the job along the class route for the job.

  1. Aggregating job exit statuses of a plurality of compute nodes executing a parallel application

    Energy Technology Data Exchange (ETDEWEB)

    Aho, Michael E.; Attinella, John E.; Gooding, Thomas M.; Mundy, Michael B.

    2015-07-21

    Aggregating job exit statuses of a plurality of compute nodes executing a parallel application, including: identifying a subset of compute nodes in the parallel computer to execute the parallel application; selecting one compute node in the subset of compute nodes in the parallel computer as a job leader compute node; initiating execution of the parallel application on the subset of compute nodes; receiving an exit status from each compute node in the subset of compute nodes, where the exit status for each compute node includes information describing execution of some portion of the parallel application by the compute node; aggregating each exit status from each compute node in the subset of compute nodes; and sending an aggregated exit status for the subset of compute nodes in the parallel computer.

  2. Distributing an executable job load file to compute nodes in a parallel computer

    Energy Technology Data Exchange (ETDEWEB)

    Gooding, Thomas M.

    2016-09-13

    Distributing an executable job load file to compute nodes in a parallel computer, the parallel computer comprising a plurality of compute nodes, including: determining, by a compute node in the parallel computer, whether the compute node is participating in a job; determining, by the compute node in the parallel computer, whether a descendant compute node is participating in the job; responsive to determining that the compute node is participating in the job or that the descendant compute node is participating in the job, communicating, by the compute node to a parent compute node, an identification of a data communications link over which the compute node receives data from the parent compute node; constructing a class route for the job, wherein the class route identifies all compute nodes participating in the job; and broadcasting the executable load file for the job along the class route for the job.

  3. Laser links for mobile airborne nodes

    Science.gov (United States)

    Griethe, Wolfgang; Knapek, Markus; Horwath, Joachim

    2015-05-01

    Remotely Piloted Aircrafts (RPA's) and especially Medium Altitude Long Endurance (MALE) and High Altitude Long Endurance (HALE) are currently operated over long distances, often across several continents. This is only made possible by maintaining Beyond Line Of Side (BLOS) radio links between ground control stations and unmanned vehicles via geostationary (GEO) satellites. The radio links are usually operated in the Ku-frequency band and used for both, vehicle command & control (C2) - it also refers to Command and Non-Payload Communication (CNPC) - as well as transmission of intelligence data - the associated communication stream also refers to Payload Link (PL). Even though this scheme of communication is common practice today, various other issues are raised thereby. The paper shows that the current existing problems can be solved by using the latest technologies combined with altered intuitive communication strategies. In this context laser communication is discussed as a promising technology for airborne applications. It is clearly seen that for tactical reasons, as for instance RPA cooperative flying, Air-to-Air communications (A2A) is more advantageous than GEO satellite communications (SatCom). Hence, together with in-flight test results the paper presents a design for a lightweight airborne laser terminal, suitable for use onboard manned or unmanned airborne nodes. The advantages of LaserCom in combination with Intelligence, Surveillance and Reconnaissance (ISR) technologies particularly for Persistent Wide Area Surveillance (PWAS) are highlighted. Technical challenges for flying LaserCom terminals aboard RPA's are outlined. The paper leads to the conclusion that by combining both, LaserCom and ISR, a new quality for an overall system arises which is more than just the sum of two separate key technologies.

  4. The STARK-B database VAMDC node

    Science.gov (United States)

    Sahal-Bréchot, S.; Dimitrijević, M. S.; Moreau, N.; Nessib, N. Ben

    2017-03-01

    Accurate spectroscopic diagnostics and modelling require the knowledge of numerous collisional line profiles. The access to such data via an on line database is essential. The aim of STARK-B is to meet these needs for widths and shifts of "isolated" lines of neutral and ionized atoms due to electron and ion impacts. It is devoted to modelling and spectroscopic diagnostics of stellar atmospheres and envelopes, laboratory plasmas, laser equipments and technological plasmas. So, the range of temperatures and densities covered by the tables is broad and depends on the ionization degree of the radiating atom. STARK-B is a collaborative project between the Astronomical Observatory of Belgrade (AOB) and the laboratory LERMA at Observatory of Paris, which started at the end of 2008. STARK-B is a database of LERMA and a node of VAMDC (Virtual Atomic and Molecular Data Centre) and thus complies with the standards of the Virtual Observatories. This database opened at the end of 2008. Today, the database contains our calculated data for a various number of transitions of neutral or ionized atoms, published in more than 150 papers in international refereed journals. We continue to implement our previously published data, and the new ones as soon as they are published. A summary of the scientific objectives, the key points of the impact-semiclassical-perturbation method used for the calculations, the current state of development of our ongoing work and our plans for the future objectives of the database are presented. Finally, an example of the results of a query is displayed.

  5. Function and dysfunction of human sinoatrial node.

    Science.gov (United States)

    Joung, Boyoung; Chen, Peng-Sheng

    2015-05-01

    Sinoatrial node (SAN) automaticity is jointly regulated by a voltage (cyclic activation and deactivation of membrane ion channels) and Ca(2+) clocks (rhythmic spontaneous sarcoplasmic reticulum Ca(2+) release). Using optical mapping in Langendorff-perfused canine right atrium, we previously demonstrated that the β-adrenergic stimulation pushes the leading pacemaker to the superior SAN, which has the fastest activation rate and the most robust late diastolic intracellular calcium (Cai) elevation. Dysfunction of the superior SAN is commonly observed in animal models of heart failure and atrial fibrillation (AF), which are known to be associated with abnormal SAN automaticity. Using the 3D electroanatomic mapping techniques, we demonstrated that superior SAN served as the earliest atrial activation site (EAS) during sympathetic stimulation in healthy humans. In contrast, unresponsiveness of superior SAN to sympathetic stimulation was a characteristic finding in patients with AF and SAN dysfunction, and the 3D electroanatomic mapping technique had better diagnostic sensitivity than corrected SAN recovery time testing. However, both tests have significant limitations in detecting patients with symptomatic sick sinus syndrome. Recently, we reported that the location of the EAS can be predicted by the amplitudes of P-wave in the inferior leads. The inferior P-wave amplitudes can also be used to assess the superior SAN responsiveness to sympathetic stimulation. Inverted or isoelectric P-waves at baseline that fail to normalize during isoproterenol infusion suggest SAN dysfunction. P-wave morphology analyses may be helpful in determining the SAN function in patients at risk of symptomatic sick sinus syndrome.

  6. Long range node-strut analysis of trabecular bone microarchitecture

    CERN Document Server

    Schmah, T; Thomsen, J S; Saparin, P

    2015-01-01

    Purpose: We present a new morphometric measure of trabecular bone microarchitecture, called mean node strength (NdStr), which is part of a newly developed approach called long range node-strut analysis. Our general aim is to describe and quantify the apparent "latticelike" microarchitecture of the trabecular bone network. Methods: Similar in some ways to the topological node-strut analysis introduced by Garrahan et al. [J. Microsc. 142, 341-349 (1986)], our method is distinguished by an emphasis on long-range trabecular connectivity. Thus, while the topological classification of a pixel (after skeletonization) as a node, strut, or terminus, can be determined from the 3x3 neighborhood of that pixel, our method, which does not involve skeletonization, takes into account a much larger neighborhood. In addition, rather than giving a discrete classification of each pixel as a node, strut, or terminus, our method produces a continuous variable, node strength. The node strength is averaged over a region of interest ...

  7. Performance Evaluation of MANET Routing Protocols under Varying Node Mobility

    Directory of Open Access Journals (Sweden)

    S.Balaji Gupta

    2013-06-01

    Full Text Available Mobile ad hoc network (MANET is an autonomous system containing a cluster of mobile nodes which can dynamically change their network topology. It requires no pre-existing fixed network infrastructureor centralized administration. It operates in a standalone fashion. All the mobile nodes in the network are connected by wireless links. These nodes are free to move anywhere and organize themselves into a network. Each node behaves as a router and should therefore forward packets to other nodes in the network. For this purpose, a routing protocol is needed. Mobile ad-hoc network has certain characteristics such as dynamic topology that inserts new demands on the routing protocol which often limits resources such as storage capacityof CPU, battery power and bandwidth. Mobility models emulate the realistic conditions and dictate the movement of nodes. This paper aims to evaluate the performance and compare the three MANET routingprotocols AODV, DSR and DSDV in different mobility conditions while varying pause time and node density. Three mobility models included are Random Waypoint, Random Walk and Random Direction. Lastly, wepresent simulation results that illustrate how the performance of a MANET protocols drastically change, as a result of changing the mobility taking Throughput, Average End-End Delay, Packet Delivery Ratio and Normalized Routing Load as differentials. The conclusion, which routing protocol is best in each of the varying mobility is also stated. Simulations are carried out using Ns2.

  8. Identifying key nodes in multilayer networks based on tensor decomposition

    Science.gov (United States)

    Wang, Dingjie; Wang, Haitao; Zou, Xiufen

    2017-06-01

    The identification of essential agents in multilayer networks characterized by different types of interactions is a crucial and challenging topic, one that is essential for understanding the topological structure and dynamic processes of multilayer networks. In this paper, we use the fourth-order tensor to represent multilayer networks and propose a novel method to identify essential nodes based on CANDECOMP/PARAFAC (CP) tensor decomposition, referred to as the EDCPTD centrality. This method is based on the perspective of multilayer networked structures, which integrate the information of edges among nodes and links between different layers to quantify the importance of nodes in multilayer networks. Three real-world multilayer biological networks are used to evaluate the performance of the EDCPTD centrality. The bar chart and ROC curves of these multilayer networks indicate that the proposed approach is a good alternative index to identify real important nodes. Meanwhile, by comparing the behavior of both the proposed method and the aggregated single-layer methods, we demonstrate that neglecting the multiple relationships between nodes may lead to incorrect identification of the most versatile nodes. Furthermore, the Gene Ontology functional annotation demonstrates that the identified top nodes based on the proposed approach play a significant role in many vital biological processes. Finally, we have implemented many centrality methods of multilayer networks (including our method and the published methods) and created a visual software based on the MATLAB GUI, called ENMNFinder, which can be used by other researchers.

  9. PVM Enhancement for Beowulf Multiple-Processor Nodes

    Science.gov (United States)

    Springer, Paul

    2006-01-01

    A recent version of the Parallel Virtual Machine (PVM) computer program has been enhanced to enable use of multiple processors in a single node of a Beowulf system (a cluster of personal computers that runs the Linux operating system). A previous version of PVM had been enhanced by addition of a software port, denoted BEOLIN, that enables the incorporation of a Beowulf system into a larger parallel processing system administered by PVM, as though the Beowulf system were a single computer in the larger system. BEOLIN spawns tasks on (that is, automatically assigns tasks to) individual nodes within the cluster. However, BEOLIN does not enable the use of multiple processors in a single node. The present enhancement adds support for a parameter in the PVM command line that enables the user to specify which Internet Protocol host address the code should use in communicating with other Beowulf nodes. This enhancement also provides for the case in which each node in a Beowulf system contains multiple processors. In this case, by making multiple references to a single node, the user can cause the software to spawn multiple tasks on the multiple processors in that node.

  10. AUTOMATIC RECOVERING NODE FAILURE IN WIRELESS SENSOR ACTOR NETWORKS

    Directory of Open Access Journals (Sweden)

    C.A.Subasini

    2015-02-01

    Full Text Available Automatic recovering node failure in wireless sensor actor network to identify the cutvertex and to meet to the node failure. The network consists of many nodes that are constructed into a tree structure. Once the tree has been constructed the shortest path is found by the Aodv protocol.If a node failure occurs in the shortest path then the cut-vertex could be recovered and the data can be securely passed on to the destination in an alternative route obtained from the routing table. Heartbeat messages acknowledge the node failure. The feasible path is not found by the protocol, and then the network is divided into two or many parts. The MLeDir algorithm is used to identify the network failure and disjoint block of the network. The disjoint block is identified by the MLeDir algorithm and to rectify the disjoint block of failure network nodes. MLeDir algorithm is moving only the respective nodes from source to destination.

  11. Computed Tomographic Evaluation of Presumptively Normal Canine Sternal Lymph Nodes.

    Science.gov (United States)

    Iwasaki, Ryota; Mori, Takashi; Ito, Yusuke; Kawabe, Mifumi; Murakmi, Mami; Maruo, Kohji

    The sternal lymph nodes receive drainage from a wide variety of structures in the thoraco-abdominal region. Evaluation of these lymph nodes is essential, especially in cancer patients. Computed tomography (CT) can detect sternal lymph nodes more accurately than radiography or ultrasonography, and the criteria of the sternal lymphadenopathy are unknown. The purpose of this retrospective study was to describe the CT characteristics of the sternal lymph nodes in dogs considered unlikely to have lymphadenopathy. The ratio of the short axis dimension of the sternal lymph nodes to the thickness of the second sternebra was also investigated. At least one sternal lymph node was identified in each of the 152 dogs included in the study. The mean long axis and short axis dimensions were 0.700 cm and 0.368 cm, respectively. The mean ratio of the sternal lymph nodes to the second sternebrae was 0.457, and the 95% prediction interval ranged from 0.317 to 0.596 (almost a fixed value independent of body weight). These findings will be useful when evaluating sternal lymphadenopathy using CT.

  12. Mobile Node for Wireless Sensor Network to Detect Landmines

    Directory of Open Access Journals (Sweden)

    P.Vijaya Kumar

    2012-03-01

    Full Text Available Individual sensor nodes are low power devices which integrate computing, wireless communication and sensing capabilities to detect land mine. Such multiple nodes collectively form wireless sensor network. To detect landmine in ground surface, sensor node that able to sense the mine and to process the information locally are mounted on a mobile robot to scan the ground surface in the organized pattern resulting in detection of all the mines present in the proposed area which is synchronized by Infrared pills; the node can communicate to the data collection point (Sink typically through wireless communication. The aggregation of such multitude of mobile nodes and a mobile sink forms a versatile mine detection unit. When the mine is detected the node routes it information to the hand held device (Base through sink and stays in it position to help the Deming crew to identify the position where the mine is present. When the Deming crew presses a button the node continues in its pattern.

  13. Extended lymph node dissection in robotic radical prostatectomy: Current status

    Directory of Open Access Journals (Sweden)

    Sameer Chopra

    2016-01-01

    Full Text Available Introduction: The role and extent of extended pelvic lymph node dissection (ePLND during radical prostatectomy (RP for prostate cancer patients remains unclear. Materials and Methods: A PubMed literature search was performed for studies reporting on treatment regimens and outcomes in patients with prostate cancer treated by RP and extended lymph node dissection between 1999 and 2013. Results: Studies have shown that RP can improve progression-free and overall survival in patients with lymph node-positive prostate cancer. While this finding requires further validation, it does allow urologists to question the former treatment paradigm of aborting surgery when lymph node invasion from prostate cancer occurred, especially in patients with limited lymph node tumor infiltration. Studies show that intermediate- and high-risk patients should undergo ePLND up to the common iliac arteries in order to improve nodal staging. Conclusions: Evidence from the literature suggests that RP with ePLND improves survival in lymph node-positive prostate cancer. While studies have shown promising results, further improvements and understanding of the surgical technique and post-operative treatment are required to improve treatment for prostate cancer patients with lymph node involvement.

  14. Identification of node behavior for Mobile Ad-hoc Network

    Directory of Open Access Journals (Sweden)

    Khyati Choure , Sanjay Sharma

    2012-12-01

    Full Text Available In present scenario, in ad-hoc network, the behavior of nodes are not very stable. They do not work properly and satisfactory. They are not cooperative and acting selfishly. They show their selfishness to share their resources like bandwidth to save life of battery, they are not hasitate to block thepackets sent by others for forwarding and transmit their own packets. Due to higher Mobility of the different nodes makes the situation even more complicated. Multiple routing protocols especially for these conditions have been developed during the last few years, to find optimized routes from a source to some destination.But it is still difficult to know the actual shortest path without attackers or bad nodes. Ad-hoc network suffer from the lot of issues i.e. congestion, Throughput, delay, security, network overhead. Packet delivery ratio is the issues of ongoing research. Cause of node failure may be either natural failure of node links or it may be due to act of an attacker or bad node which may degrade performance of network slowly or drastically, which also need to identify or determined. In this paper, we identify the good and bad nodes. A simulation has been performed to achieve better performance of modified AODV. Good result has been obtained in terms of Throughout, Packet Delivery Ratio.

  15. Crawler for Nodes in the Internet of Things

    Institute of Scientific and Technical Information of China (English)

    Wenchao Jia

    2015-01-01

    Determining the application and version of nodes in the Inter⁃net of Things (IoT) is very important for warning about and managing vulnerabilities in the IoT. This article defines the attributes for determining the application and version of nodes in the IoT. By improving the structure of the Internet web crawler, which obtains raw data from nodes, we can obtain da⁃ta from nodes in the IoT. We improve on the existing strate⁃gy, in which only determinations are stored, by also storing downloaded raw data locally in MongoDB. This stored raw da⁃ta can be conveniently used to determine application type and node version when a new determination method emerges or when there is a new application type or node version. In such instances, the crawler does not have to scan the Internet again. We show through experimentation that our crawler can crawl the IoT and obtain data necessary for determining the application type and node version.

  16. Final report for the mobile node authentication LDRD project.

    Energy Technology Data Exchange (ETDEWEB)

    Michalski, John T.; Lanzone, Andrew J.

    2005-09-01

    In hostile ad hoc wireless communication environments, such as battlefield networks, end-node authentication is critical. In a wired infrastructure, this authentication service is typically facilitated by a centrally-located ''authentication certificate generator'' such as a Certificate Authority (CA) server. This centralized approach is ill-suited to meet the needs of mobile ad hoc networks, such as those required by military systems, because of the unpredictable connectivity and dynamic routing. There is a need for a secure and robust approach to mobile node authentication. Current mechanisms either assign a pre-shared key (shared by all participating parties) or require that each node retain a collection of individual keys that are used to communicate with other individual nodes. Both of these approaches have scalability issues and allow a single compromised node to jeopardize the entire mobile node community. In this report, we propose replacing the centralized CA with a distributed CA whose responsibilities are shared between a set of select network nodes. To that end, we develop a protocol that relies on threshold cryptography to perform the fundamental CA duties in a distributed fashion. The protocol is meticulously defined and is implemented it in a series of detailed models. Using these models, mobile wireless scenarios were created on a communication simulator to test the protocol in an operational environment and to gather statistics on its scalability and performance.

  17. Exploring the evolution of node neighborhoods in Dynamic Networks

    Science.gov (United States)

    Orman, Günce Keziban; Labatut, Vincent; Naskali, Ahmet Teoman

    2017-09-01

    Dynamic Networks are a popular way of modeling and studying the behavior of evolving systems. However, their analysis constitutes a relatively recent subfield of Network Science, and the number of available tools is consequently much smaller than for static networks. In this work, we propose a method specifically designed to take advantage of the longitudinal nature of dynamic networks. It characterizes each individual node by studying the evolution of its direct neighborhood, based on the assumption that the way this neighborhood changes reflects the role and position of the node in the whole network. For this purpose, we define the concept of neighborhood event, which corresponds to the various transformations such groups of nodes can undergo, and describe an algorithm for detecting such events. We demonstrate the interest of our method on three real-world networks: DBLP, LastFM and Enron. We apply frequent pattern mining to extract meaningful information from temporal sequences of neighborhood events. This results in the identification of behavioral trends emerging in the whole network, as well as the individual characterization of specific nodes. We also perform a cluster analysis, which reveals that, in all three networks, one can distinguish two types of nodes exhibiting different behaviors: a very small group of active nodes, whose neighborhood undergo diverse and frequent events, and a very large group of stable nodes.

  18. Fluorescence imaging to study cancer burden on lymph nodes

    Science.gov (United States)

    D'Souza, Alisha V.; Elliott, Jonathan T.; Gunn, Jason R.; Samkoe, Kimberley S.; Tichauer, Kenneth M.; Pogue, Brian W.

    2015-03-01

    Morbidity and complexity involved in lymph node staging via surgical resection and biopsy calls for staging techniques that are less invasive. While visible blue dyes are commonly used in locating sentinel lymph nodes, since they follow tumor-draining lymphatic vessels, they do not provide a metric to evaluate presence of cancer. An area of active research is to use fluorescent dyes to assess tumor burden of sentinel and secondary lymph nodes. The goal of this work was to successfully deploy and test an intra-nodal cancer-cell injection model to enable planar fluorescence imaging of a clinically relevant blue dye, specifically methylene blue along with a cancer targeting tracer, Affibody labeled with IRDYE800CW and subsequently segregate tumor-bearing from normal lymph nodes. This direct-injection based tumor model was employed in athymic rats (6 normal, 4 controls, 6 cancer-bearing), where luciferase-expressing breast cancer cells were injected into axillary lymph nodes. Tumor presence in nodes was confirmed by bioluminescence imaging before and after fluorescence imaging. Lymphatic uptake from the injection site (intradermal on forepaw) to lymph node was imaged at approximately 2 frames/minute. Large variability was observed within each cohort.

  19. Simulation of the Physical Performance of Optical Packet Switching Nodes

    Institute of Scientific and Technical Information of China (English)

    王春华; 李力; 等

    2002-01-01

    A graphical and visual simulation system for the study of optical packet switching(OPS)nodes is accomplished.With the simulation system,the effect on physical performance-bit error rate(BER)due to a variety of factors such as the crosstalk parameters of OPS nodes,number of cascaded OPS nodes,length of optical output buffer,traffic load and fluctuation of amplitude of optical signals are evaluated.Reliability of the simulation system is proved by the analytical results obtained in all the above cases.

  20. Design & implementation of distributed spatial computing node based on WPS

    Science.gov (United States)

    Liu, Liping; Li, Guoqing; Xie, Jibo

    2014-03-01

    Currently, the research work of SIG (Spatial Information Grid) technology mostly emphasizes on the spatial data sharing in grid environment, while the importance of spatial computing resources is ignored. In order to implement the sharing and cooperation of spatial computing resources in grid environment, this paper does a systematical research of the key technologies to construct Spatial Computing Node based on the WPS (Web Processing Service) specification by OGC (Open Geospatial Consortium). And a framework of Spatial Computing Node is designed according to the features of spatial computing resources. Finally, a prototype of Spatial Computing Node is implemented and the relevant verification work under the environment is completed.

  1. Influence of racemic higenamine on the sinus node

    OpenAIRE

    Yu, Fengxia; KONG, LINGTING; Wang, Shujuan

    2012-01-01

    The aim of this study was to explore the mechanism of racemic higenamine in the treatment of sick sinus syndrome (SSS). A total of 40 New Zealand rabbits were randomly divided into normal sinus node and damaged sinus node (SND) groups, and each group was randomly divided into treatment and control groups (n=10). The SND model was established by formaldehyde wet dressing of the sinus node area. The treatment groups were administered an intravenous infusion of 0.04 mg/kg racemic higenamine via ...

  2. Long range node-strut analysis of trabecular bone microarchitecture

    DEFF Research Database (Denmark)

    Schmah, Tanya; Marwan, Norbert; Thomsen, Jesper Skovhus

    2011-01-01

    of the trabecular bone network. METHODS: Similar in some ways to the topological node-strut analysis introduced by Garrahan et al. [J. Microsc. 142, 341-349 (1986)], our method is distinguished by an emphasis on long-range trabecular connectivity. Thus, while the topological classification of a pixel (after...... skeletonization) as a node, strut, or terminus, can be determined from the 3 × 3 neighborhood of that pixel, our method, which does not involve skeletonization, takes into account a much larger neighborhood. In addition, rather than giving a discrete classification of each pixel as a node, strut, or terminus, our...

  3. OPTIMASI KINERJA PROTOKOL AODV DENGAN STATIC INTERSECTION NODE

    Directory of Open Access Journals (Sweden)

    Johan Ericka Wahyu Prakasa

    2016-07-01

    Full Text Available VANET adalah sebuah pengembangan teknologi yang memungkinkan komunikasi antar kendaraan meskipun tidak terdapat koneksi secara langsung antara kendaraan yang berkomunikasi. Untuk meningkatkan performa protokol routing, maka pada penelitian ini akan ditambahkan SIN (Static Intersection Node. Static Intersection Node adalah RSU (Road Side Unit yang diletakkan di persimpangan jalan (intersection. Fungsi dari Static Intersection Node pada penelitian ini adalah sebagai repeater untuk membantu mengirimkan paket data ke kendaraan lain yang berada disekitarnya sehingga dapat meningkatkan Packet Delivery Ratio serta meminimalkan Packet Loss dan End to End Delay.

  4. Diffusion on a tree with stochastically gated nodes

    Science.gov (United States)

    Bressloff, Paul C.; Lawley, Sean D.

    2016-06-01

    We consider diffusion on a tree with nodes that randomly switch between allowing and prohibiting particles to pass. We find exact expressions for various splitting probabilities and mean first passage times for a single diffusing particle and show how the many parameters in the problem, such as the node gating statistics and tree topology, contribute to these exit statistics. We also consider a concentration of particles that can always pass through interior branch nodes and determine how an intermittent source at one end of the tree affects the flux at the other end. The latter problem is motivated by applications to insect respiration.

  5. On Identifying which Intermediate Nodes Should Code in Multicast Networks

    DEFF Research Database (Denmark)

    Pinto, Tiago; Roetter, Daniel Enrique Lucani; Médard, Muriel

    2013-01-01

    the data packets. Previous work has shown that in lossless wireline networks, the performance of tree-packing mechanisms is comparable to network coding, albeit with added complexity at the time of computing the trees. This means that most nodes in the network need not code. Thus, mechanisms that identify...... intermediate nodes that do require coding is instrumental for the efficient operation of coded networks and can have a significant impact in overall energy consumption. We present a distributed, low complexity algorithm that allows every node to identify if it should code and, if so, through what output link...

  6. DETECTION OF OCCULT LYMPH NODE TUMOR CELLS IN NODE-NEGATIVE GASTRIC CANCER PATIENTS.

    Science.gov (United States)

    Pereira, Marina Alessandra; Ramos, Marcus Fernando Kodama Pertille; Dias, Andre Roncon; Yagi, Osmar Kenji; Faraj, Sheila Friedrich; Zilberstein, Bruno; Cecconello, Ivan; Mello, Evandro Sobroza de; Ribeiro-Jr, Ulysses

    2017-01-01

    The presence of lymph nodes metastasis is one of the most important prognostic indicators in gastric cancer. The micrometastases have been studied as prognostic factor in gastric cancer, which are related to decrease overall survival and increased risk of recurrence. However, their identification is limited by conventional methodology, since they can be overlooked after routine staining. To investigate the presence of occult tumor cells using cytokeratin (CK) AE1/AE3 immunostaining in gastric cancer patients histologically lymph node negative (pN0) by H&E. Forty patients (T1-T4N0) submitted to a potentially curative gastrectomy with D2 lymphadenectomy were evaluated. The results for metastases, micrometastases and isolated tumor cells were also associated to clinicopathological characteristics and their impact on stage grouping. Tumor deposits within lymph nodes were defined according to the tumor-node-metastases guidelines (7th TNM). A total of 1439 lymph nodes were obtained (~36 per patient). Tumor cells were detected by immunohistochemistry in 24 lymph nodes from 12 patients (30%). Neoplasic cells were detected as a single or cluster tumor cells. Tumor (p=0.002), venous (p=0.016), lymphatic (p=0.006) and perineural invasions (p=0.04), as well as peritumoral lymphocytic response (p=0.012) were correlated to CK-positive immunostaining tumor cells in originally negative lymph nodes by H&E. The histologic stage of two patients was upstaged from stage IB to stage IIA. Four of the 28 CK-negative patients (14.3%) and three among 12 CK-positive patients (25%) had disease recurrence (p=0.65). The CK-immunostaining is an effective method for detecting occult tumor cells in lymph nodes and may be recommended to precisely determine tumor stage. It may be useful as supplement to H&E routine to provide better pathological staging. A presença de metástase em linfonodos é um dos indicadores prognósticos mais importantes no câncer gástrico. As micrometástases têm sido

  7. Synthetic vaccine nanoparticles target to lymph node triggering enhanced innate and adaptive antitumor immunity.

    Science.gov (United States)

    Kim, Sun-Young; Noh, Young-Woock; Kang, Tae Heung; Kim, Jung-Eun; Kim, Sohyun; Um, Soong Ho; Oh, Doo-Byoung; Park, Yeong-Min; Lim, Yong Taik

    2017-06-01

    In this study, synthetic vaccine nanoparticles (SVNPs) that efficiently targeted lymph nodes, where immune responses against foreign antigens are primed, were developed to enhance antitumor immunity. The size (20-70 nm) and surface character (amination) of poly(γ-glutamic acid)-based SVNPs were selected for effective loading and delivery (i.e., migration and retention) of model tumor antigen (OVA) and toll-like receptor 3 agonist (poly (I:C)) to immune cells in lymph nodes. Antigen-presenting cells treated with SVNP-OVA and SVNP-IC showed higher uptake of OVA and poly (I:C) and higher secretion of inflammatory cytokines (TNF-α, IL-6) and type I interferon (IFN-α, IFN-β) than those treated with OVA and poly (I:C) alone. In vivo analysis revealed higher levels of activation markers, inflammatory cytokines, and type I IFNs in the lymph nodes of mice immunized with SVNP-IC compared to those of mice in other groups. SVNP-IC-treated mice showed significantly greater in vivo natural killer cell expansion/activation (NK1.1(+) cells) and CD8(+) T cell response (CD8(+) INF-γ(+) cells) in innate and adaptive immunity, respectively. Both preventive and therapeutic vaccination of EG7-OVA tumor-bearing mice using the simultaneous injection of both SVNP-OVA and SVNP-IC induced higher antitumor immunity and inhibited tumor growth. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis

    Directory of Open Access Journals (Sweden)

    Jie Chen

    2012-01-01

    Full Text Available In the 1970s, the late Judah Folkman postulated that tumors grow proportionately to their blood supply and that tumor angiogenesis removed this limitation promoting growth and metastasis. Work over the past 40 years, varying from molecular examination to clinical trials, verified this hypothesis and identified a host of therapeutic targets to limit tumor angiogenesis, including the integrin family of extracellular matrix receptors. However, the propensity for some tumors to spread through lymphatics suggests that lymphangiogenesis plays a similarly important role. Lymphangiogenesis inhibitors reduce lymph node metastasis, the leading indicator of poor prognosis, whereas inducing lymphangiogenesis promotes lymph node metastasis even in cancers not prone to lymphatic dissemination. Recent works highlight a role for integrins in lymphangiogenesis and suggest that integrin inhibitors may serve as therapeutic targets to limit lymphangiogenesis and lymph node metastasis. This review discusses the current literature on integrin-matrix interactions in lymphatic vessel development and lymphangiogenesis and highlights our current knowledge on how specific integrins regulate tumor lymphangiogenesis.

  9. On-demand multicast routing protocol based on node classification in MANET

    Institute of Scientific and Technical Information of China (English)

    DENG Xia; SUN Li-min; WANG Jian-xin; LUO Yu-hong; CHEN Jian-er

    2006-01-01

    An improved on-demand multicast routing protocol(ODMRP), node classification on-demand multicast routing protocol(NC-ODMRP), which is based on node classification in mobile ad hoc networks was proposed. NCODMRP classifies nodes into such three categories as ordinary node, forwarding group(FG) node, neighbor node of FG node according to their history forwarding information. The categories are distinguished with different weights by a weight table in the nodes. NC-ODMRP chooses the node with the highest weight as an FG node during the setup of forwarding group, which reduces a lot of redundant FG nodes by sharing more FG nodes between different sender and receiver pairs. The simulation results show that NC-ODMRP can reduce more than 20% FG number of ODMRP, thus enhances nearly 14% data forwarding efficiency and 12% energy consumption efficiency when the number of multicast senders is more than 5.

  10. Anatomic distribution of supraclavicular lymph node in patients with esophageal cancer

    National Research Council Canada - National Science Library

    Xing, Jun; Luo, Yijun; Wang, Xiaoli; Gao, Min; Sun, Mingping; Ding, Xiuping; Fan, Tingyong; Yu, Jinming

    2016-01-01

    ...), especially for lower cervical lymph nodes. This study aimed to map the location of metastatic supraclavicular lymph nodes in thoracic esophageal carcinoma patients with supraclavicular node involvement and generate an atlas to delineate...

  11. File list: Pol.CDV.50.AllAg.Sinoatrial_Node [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.CDV.50.AllAg.Sinoatrial_Node mm9 RNA polymerase Cardiovascular Sinoatrial Node ...http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.CDV.50.AllAg.Sinoatrial_Node.bed ...

  12. File list: Pol.CDV.10.AllAg.Sinoatrial_Node [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.CDV.10.AllAg.Sinoatrial_Node mm9 RNA polymerase Cardiovascular Sinoatrial Node ...http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.CDV.10.AllAg.Sinoatrial_Node.bed ...

  13. File list: Pol.CDV.20.AllAg.Sinoatrial_Node [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.CDV.20.AllAg.Sinoatrial_Node mm9 RNA polymerase Cardiovascular Sinoatrial Node ...http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.CDV.20.AllAg.Sinoatrial_Node.bed ...

  14. Error recovery to enable error-free message transfer between nodes of a computer network

    Energy Technology Data Exchange (ETDEWEB)

    Blumrich, Matthias A.; Coteus, Paul W.; Chen, Dong; Gara, Alan; Giampapa, Mark E.; Heidelberger, Philip; Hoenicke, Dirk; Takken, Todd; Steinmacher-Burow, Burkhard; Vranas, Pavlos M.

    2016-01-26

    An error-recovery method to enable error-free message transfer between nodes of a computer network. A first node of the network sends a packet to a second node of the network over a link between the nodes, and the first node keeps a copy of the packet on a sending end of the link until the first node receives acknowledgment from the second node that the packet was received without error. The second node tests the packet to determine if the packet is error free. If the packet is not error free, the second node sets a flag to mark the packet as corrupt. The second node returns acknowledgement to the first node specifying whether the packet was received with or without error. When the packet is received with error, the link is returned to a known state and the packet is sent again to the second node.

  15. Detection and significance of lymph node micro-Metastases in patients with node-negative gastric carcinoma

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    To study micrometastases in lymph nodes from patients with node-negative gastric carcinoma by routine histologic examination and discuss their prognostic significance and the relationship between micrometastases and each of the clinicopathologic factors. Methods: A total of 1245 perigastric lymph nodes from 105 patients with node-negative gastric carcinoma was immunohistochemically detected using a monoclonal antibody against low molecular weight cytokeratin AE1. The characteristics of the micrometastases, their related factors and effect on patients' survival after surgery were analysed and tested with statistical methods. Results: Micrometastases were observed in 81 lymph nodes (6.5%) of 31 patients (29.5%). The incidence of lymph node micrometastases was significantly higher in the diffuse type (41.5%) than in the intestinal type gastric carcinoma (17.6%, P<0.01, x2 test). In addition, the presence of micrometastases was closely correlated with the size and invasion depth of the primary tumor, but had no relation to patient's age, sex and the location of primary tumor. The patients with micrometastases had significantly worse prognosis shown by Log-rank test. Their five-year survival rate after surgery was 61.29%; for those without micrometastases the rate was 82.43%, P=0.0116. When the number of patient's lymph nodes with micrometastases was three or more, the five-year survival rate of these patients was much lower (41.67%, P=0.0012). Conclusion: The detection of lymph node micrometastases is necessary to more accurately determine the prognosis and clinical staging of patients with node- negative gastric carcinoma by routine histologic examination. The presence of micrometastases may be regarded as one of the clues in adjuvant therapy of those patients.

  16. Clinicopathologic subtypes and compromise of lymph nodes in patients with breast cancer

    Science.gov (United States)

    Jaime Jans, B; Nicolás Escudero, M; Dahiana Pulgar, B; Francisco Acevedo, C; César Sánchez, R; Camus, A Mauricio

    2014-01-01

    Breast cancer (BC) is currently a heterogeneous disease with variations in clinical behaviour. Classification according to subtypes has allowed progress in the individualisation of treatment. The objective of this study is to evaluate the risk of axillary node compromise in patients with BC, according to clinicopathologic subtypes. Materials and methods are a retrospective, descriptive-analytical study. All patients that had undergone surgery for invasive BC were included, with the study of sentinel lymph nodes (SLNs) at Hospital Clínico de la Pontificia Universidad Católica, between May 1999 and December 2012. The results showed 632 patients fulfilled the inclusion criteria, with the median age being 55 years (range: 28–95), and 559 (88.4%) patients presented with estrogen receptor and/or progesterone receptor positive tumours. Luminal A: 246 patients (38.9%), luminal B: 243 (38.4%), luminal not otherwise specified: 70 (11.1%) triple negative (TN): 60 (9.5%) and over expression of epidermal growth factor type 2 receptor (HER2 positive): 13 (2.1%). Luminal tumours displayed a greater risk of metastasis in the SLNs, but this difference was not statistically significant (p = 0.67). TN and HER2 positive tumours presented the greatest proportion of metastatic compromise in non-sentinel lymph nodes (non-SLNs) (57.1% and 50%, respectively). The presence of macrometastasis (MAM) in the SLN was associated with a greater risk of compromise of the non-SLN. Conclusions: Luminal tumours are the most frequent and present a greater proportion of axillary lymph node compromise, without being statistically significant. TN and HER2 positive tumours tend to have a higher axillary compromise; however, this was not statistically significant in either. Only the presence of MAM in SLNs displayed a statistically significantly association in the compromise of non-SLNs. PMID:25114720

  17. Ultrasound elastography for evaluation of cervical lymph nodes

    Directory of Open Access Journals (Sweden)

    Young Jun Choi

    2015-07-01

    Full Text Available Ultrasound (US elastography has been introduced as a noninvasive imaging technique for evaluating cervical lymph nodes. US elastography techniques include strain elastography and shear wave-based elastography. The application of this technique is based on the fact that stiff tissues tend to deform less and show less strain than compliant tissues when the same force is applied. In general, metastatic lymph nodes demonstrate higher stiffness than benign lymph nodes. Overall, preliminary studies suggest that US elastography may be useful in differentiating benign and malignant cervical lymph nodes, thereby informing decisions to perform a biopsy and facilitating follow-up. For US elastography to be accepted into clinical practice, however, its techniques, associated diagnostic criteria, and reliability need to be further refined.

  18. Watersheds, waterfalls, on edge or node weighted graphs

    CERN Document Server

    Meyer, Fernand

    2012-01-01

    We present an algebraic approach to the watershed adapted to edge or node weighted graphs. Starting with the flooding adjunction, we introduce the flooding graphs, for which node and edge weights may be deduced one from the other. Each node weighted or edge weighted graph may be transformed in a flooding graph, showing that there is no superiority in using one or the other, both being equivalent. We then introduce pruning operators extract subgraphs of increasing steepness. For an increasing steepness, the number of never ascending paths becomes smaller and smaller. This reduces the watershed zone, where catchment basins overlap. A last pruning operator called scissor associates to each node outside the regional minima one and only one edge. The catchment basins of this new graph do not overlap and form a watershed partition. Again, with an increasing steepness, the number of distinct watershed partitions contained in a graph becomes smaller and smaller. Ultimately, for natural image, an infinite steepness le...

  19. Coexisting coherent and incoherent domains near saddle-node bifurcation

    Science.gov (United States)

    Chandrasekar, V. K.; Suresh, R.; Senthilkumar, D. V.; Lakshmanan, M.

    2015-09-01

    A common external forcing can cause a saddle-node bifurcation in an ensemble of identical Duffing oscillators by breaking the symmetry of the individual bistable (double-well) unit. The strength of the forcing determines the separation between the saddle and the node, which in turn dictates different dynamical transitions depending on the distribution of the initial states of the oscillators. In particular, chimera-like states appear in the vicinity of the saddle-node bifurcation for which theoretical explanation is provided from the stability of the steady state of the slow-scale dynamics of the original system of equations. Further, we have also established similar states by replacing the external forcing with an appropriate coupling between the oscillators in the same parameter space. Additionally, we have also designed an appropriate coupling that can lead to saddle-node bifurcation due to symmetry breaking of the bistable systems in the vicinity of which the synchronized and desynchronized domains coexist.

  20. [Irradiation of internal mammary nodes: State of the art].

    Science.gov (United States)

    Kirova, Y M; de Almeida, C E; Fournier-Bidoz, N

    2015-06-01

    In the adjuvant breast cancer treatment, postoperative radiotherapy plays a principal part with an action against the microscopic residual disease in the lymph nodes after mastectomy as well as after breast conserving surgery. This positive effect is observed also in the case of small inner lesions in patients without lymph node involvement. At the same time, there is a recognized risk of cardiac toxicity directly related to the irradiation of internal mammary nodes. This paper is a report on the current available techniques to irradiate the internal mammary nodes, including promising new technology that may help limiting the risk of cardiac toxicity. Copyright © 2015 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

  1. Shadow networks: Discovering hidden nodes with models of information flow

    CERN Document Server

    Bagrow, James P; Frank, Morgan R; Manukyan, Narine; Mitchell, Lewis; Reagan, Andrew; Bloedorn, Eric E; Booker, Lashon B; Branting, Luther K; Smith, Michael J; Tivnan, Brian F; Danforth, Christopher M; Dodds, Peter S; Bongard, Joshua C

    2013-01-01

    Complex, dynamic networks underlie many systems, and understanding these networks is the concern of a great span of important scientific and engineering problems. Quantitative description is crucial for this understanding yet, due to a range of measurement problems, many real network datasets are incomplete. Here we explore how accidentally missing or deliberately hidden nodes may be detected in networks by the effect of their absence on predictions of the speed with which information flows through the network. We use Symbolic Regression (SR) to learn models relating information flow to network topology. These models show localized, systematic, and non-random discrepancies when applied to test networks with intentionally masked nodes, demonstrating the ability to detect the presence of missing nodes and where in the network those nodes are likely to reside.

  2. Node Heterogeneity for Energy Efficient Synchronization for Wireless Sensor Network

    DEFF Research Database (Denmark)

    Dnyaneshwar, Mantri; Prasad, Neeli R.; Prasad, Ramjee

    2016-01-01

    The energy of the node in the Wireless Sensor Networks (WSNs) is scare and causes the variation in the lifetime of the network. Also, the throughput and delay of the network depend on how long the network sustains i.e. energy consumption. One way to increase the sustainability of network...... is the introduction of heterogeneous nodes regarding energy, and the other is to synchronize the local clock of the node with the global clock of the network. In this context, the paper proposes Node Heterogeneity aware Energy Efficient Synchronization Algorithm (NHES). It works on the formation of cluster...... of the sources of delay and energy consumption. To minimize the energy consumptions and delay, NHES synchronizes the time slots using TDMA based MAC protocol. The results show that level by level synchronization used in NHES is energy efficient and has less delay as compared to the state-of-the-art solutions...

  3. Popeye proteins: muscle for the aging sinus node.

    Science.gov (United States)

    Boukens, Bastiaan J; Christoffels, Vincent M

    2012-03-01

    The electrical impulses that dictate the rhythm of the heartbeat in normal situations and during exercise or stress are initiated by a small number of sinus node pacemaker cells. Senescence and dysfunction of the sinus node affects many people later in life, causing physiologically inappropriate heart rates, but the underlying mechanisms are not well understood. In this issue of the JCI, Froese and colleagues show that deficiency in either Popeye domain containing 1 (Popdc1) or Popdc2 leads to sinus node dysfunction under stressed conditions in aged mice. The mechanism reported to underlie the effects of Popdc1/2 deficiency in mice may cause the stress-induced sinus node dysfunction found in many aged individuals and may point to new strategies for therapeutic intervention.

  4. Is sodium current present in human sinoatrial node cells?

    Directory of Open Access Journals (Sweden)

    Arie O. Verkerk, Ronald Wilders, Marcel M.G.J. van Borren, Hanno L. Tan

    2009-01-01

    Full Text Available Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (INa plays a role in the pacemaker activity of the human sinoatrial node. Recently, we had the unique opportunity to perform patch-clamp experiments on single pacemaker cells isolated from a human sinoatrial node. In 2 out of the 3 cells measured, we observed large inward currents with characteristics of INa. Although we were unable to analyze the current in detail, our findings provide strong evidence that INa is present in human sinoatrial node pacemaker cells, and that this INa is functionally available at potentials negative to -60 mV.

  5. RSW Node Centered Coarse Grid w/ Split Walls Modified

    Data.gov (United States)

    National Aeronautics and Space Administration — Dr. Chwalowski, We just generated a modified version of the coarse node centered grid with split walls. Here the red and green sections you highlighted in the email...

  6. Mobile Anchor Assisted Node Localization for Wireless Sensor Networks

    CERN Document Server

    Chen, Hongyang; Huang, Pei; Poor, H Vincent; Sezaki, Kaoru

    2009-01-01

    In this paper, a cooperative localization algorithm is proposed that considers the existence of obstacles in mobilityassisted wireless sensor networks (WSNs). In this scheme, a mobile anchor (MA) node cooperates with static sensor nodes and moves actively to refine location performance. The localization accuracy of the proposed algorithm can be improved further by changing the transmission range of mobile anchor node. The algorithm takes advantage of cooperation betweenMAs and static sensors while, at the same time, taking into account the relay node availability to make the best use of beacon signals. For achieving high localization accuracy and coverage, a novel convex position estimation algorithm is proposed, which can effectively solve the localization problem when infeasible points occur because of the effects of radio irregularity and obstacles. This method is the only range-free based convex method to solve the localization problem when the feasible set of localization inequalities is empty. Simulatio...

  7. THE DIVERGENCE OF LAGRANGE INTERPOLATION IN EQUIDISTANT NODES

    Institute of Scientific and Technical Information of China (English)

    Lu Zhikang; Xia Mao

    2003-01-01

    It is a classical result of Bernstein that the sequence of Lagrange interpolation polynomials to | x | at equally spaced nodes in [- 1,1] diverges everywhere, except at zero and the end-points. In this paper we show that the sequence of Lagrange interpolation polynomials corresponding to the functions which possess better smoothness on equidistant nodes in [-1,1] still diverges every where in the interval except at zero and the end-points.

  8. Morphology of Neptune Node Sites, Barkley Canyon, Cascadia Margin

    Science.gov (United States)

    Lundsten, E. M.; Anderson, K.; Paull, C. K.; Caress, D. W.; Thomas, H. J.; Riedel, M.

    2014-12-01

    High-resolution multibeam bathymetry and chirp seismic reflection profiles collected with MBARI's mapping autonomous underwater vehicle reveal the fine-scale morphology and shallow seafloor structure of the flanks and floor of Barkley Canyon on the Cascadia continental margin off British Columbia. The surveys characterize the environment surrounding three nodes on the Neptune Canada cabled observatory located within the canyon. The canyon floor between 960 and 1020 m water depth lacks channeling and contains ≥ 24 m of acoustically uniform sediment fill, which is ponded between the canyon's steep sidewalls. The fill overlies a strong reflector that outlines an earlier, now buried, canyon floor channel system. Debris flow tongues contain meter scale blocks sticking-up through the fill. Apparently the present geomorphology surrounding the Canyon Axis node in 985 m is attributable to local debris flows, rather than organized down canyon processes. In the survey area the canyon sidewalls extend ~300 m up and in places the slope of the canyons sides exceed 40°. Both the Hydrate node in 870 m water depths and the Mid-Canyon node at 890 m are located on a headland that forms intermediate depth terraces on the canyon's western flank. While the seafloor immediately surrounding the Mid-canyon node is smooth, the Hydrate node is marked by 10 circular mounds up to 2 m high and 10 m in diameter, presumable associated with hydrate formation. Although wedges of sediment drape occur in places on the canyon sides, the chirp profiles show no detectible sediment drape at either node site and suggest these nodes are situated on older, presumably pre-Quaternary strata. The lack of reflectors in the chirp profiles indicates most of the canyon's sidewalls are largely sediment-bare. Lineations in the bathymetry mark the exposed edges of truncated beds. Rough, apparently fresh textures, within slide scarps show the importance of erosion on the development of the canyon flanks.

  9. Immunolymphoscintigraphy for metastatic sentinel nodes: test of a model

    DEFF Research Database (Denmark)

    Chakera, A H; Nielsen, Boye S.; Madsen, J;

    2011-01-01

    Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune-deficient (nude) mice with xenograft human...... in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging....

  10. Popeye proteins: muscle for the aging sinus node

    OpenAIRE

    Boukens, Bastiaan J.; Christoffels, Vincent M.

    2012-01-01

    The electrical impulses that dictate the rhythm of the heartbeat in normal situations and during exercise or stress are initiated by a small number of sinus node pacemaker cells. Senescence and dysfunction of the sinus node affects many people later in life, causing physiologically inappropriate heart rates, but the underlying mechanisms are not well understood. In this issue of the JCI, Froese and colleagues show that deficiency in either Popeye domain containing 1 (Popdc1) or Popdc2 leads t...

  11. Fine needle aspiration cytology of palpable supraclavicular lymph nodes

    Directory of Open Access Journals (Sweden)

    RC Adhikari

    2011-03-01

    Full Text Available Background: Fine needle aspiration cytology as a first line of investigation has assumed importance in diagnosing a variety of disease process. The aim of this study was to assess the diagnostic value of fine needle aspiration cytology in the evaluation of palpable supraclavicular lymph nodes. Materials and methods: This was a retrospective study of fine needle aspiration cytology of palpable supraclavicular lymph node done between January 1, 2007 and December 31, 2009. Fine needle aspiration cytology was performed on 149 patients (49 cases at Om Hospital & Research Centre and 100 cases at Tribhuvan University Teaching Hospital. Results: The right supraclavicular lymph node was enlarged in 55% cases, while the left supraclavicular lymph node alone was palpable in 40.3% cases and in 7 of 149 (4.7% cases, bilateral supraclavicular lymph nodes were palpable. Cytological diagnoses were categorized as reactive (8.7%, tuberculosis (41.6%, lymphoma (4.8% and metastasis (44.9%. Of a total of 74 cases of malignancy, 90.5% were non-lymphoid and 9.5% were lymphoid (5 Non-Hodgkin lymphoma and 2 Hodgkin lymphoma. Of the 67 cases of metastatic disease, three major types of malignancy found in supraclavicular lymph nodes were Squamous cell carcinoma (28 cases, adenocarcinoma (21 cases and others (small cell carcinoma, papillary thyroid carcinoma etc. Adenocarcinoma tended to metastasize to the left supraclavicular lymph node. Lung was the most common primary site (43.3%, followed by stomach, ovary, breast and larynx. However, in 28.4% cases, no primary site was found. Conclusion: The fine needle aspiration cytology can be used as a first line investigation in the evaluation of supraclavicular lymphadenopathy due to its low cost, simplicity and minimal invasiveness. Keywords: Supraclavicular lymph node; Fine needle aspiration cytology; Metastasis DOI: 10.3126/jpn.v1i1.4441 Journal of Pathology of Nepal (2011 Vol.1, 8-12  

  12. Dynamic Evolution in Social Cooperation Networks with Node Failure

    OpenAIRE

    Yaofeng Zhang; Renbin Xiao

    2013-01-01

    Social cooperation networks are a kind of social networks in which individuals are linked through cooperation. Interference of economic crises, natural disasters and other emergencies may cause the node fails in social cooperation networks. To further study the influences of node failure on the total fitness degree and the cooperative ratio in social cooperation networks, the update rules of individual strategy and networks self-repair are constructed on the basis of the social cooperation ne...

  13. Isolated Axillary Lymph Node Metastasis from Serous Ovarian Cancer

    Directory of Open Access Journals (Sweden)

    Hemant Goyal

    2012-01-01

    Full Text Available A 68-year-old female with past medical history of stage IIIc serous ovarian cancer after cytoreductive surgery and adjuvant chemotherapy came to clinic for regular follow-up visit. Physical examination was completely normal except for an isolated left axillary lymph node enlargement. Patient's abdominal sonogram and CT scan of abdomen and pelvis did not show any other new metastasis. Surgical excisional biopsy of the lymph node was performed and pathology revealed features of metastatic serous ovarian carcinoma.

  14. Compressive Sleeping Wireless Sensor Networks With Active Node Selection

    OpenAIRE

    Chen, Wei; Wassell, Ian J.

    2014-01-01

    This is the author accepted manuscript. The final version is available from IEEE via http://dx.doi.org/10.1109/GLOCOM.2014.7036776 In this paper, we propose an active node selection framework for compressive sleeping wireless sensor networks (WSNs) in order to improve the signal acquisition performance and network lifetime. The node selection can be seen as a specialized sensing matrix design problem where the sensing matrix consists of selected rows of an identity matrix. By capitalizing ...

  15. Lymph node hemangioma in one-humped camel

    OpenAIRE

    Aljameel, M.A.; M.O. Halima

    2015-01-01

    Hemangioma is a benign tumor of blood and lymphatic vessels. It is common in skin, mucosa and soft tissues, and its occurrence in lymph nodes is extremely rare. A 10 year-old she-camel was slaughtered at Nyala slaughterhouse, South Darfur State, Sudan. Grossly, the carcass was emaciated. The left ventral superficial cervical lymph node was enlarged, hard on palpation and protruded outside the body. Its cut surface was dark red in color and measured (18 cm) in diameter. Histopathologically, th...

  16. Small World Model-Based Polylogarithmic Routing Using Mobile Nodes

    Institute of Scientific and Technical Information of China (English)

    Jie Wu; Shu-Hui Yang

    2008-01-01

    The use of mobile nodes to improve network system performance has drawn considerable attention recently.The movement-assisted model considers mobility as a desirable feature, where routing is based on the store-carry-forward paradigm with random or controlled movement of resource rich mobile nodes. The application of such a model has been used in several emerging networks, including mobile ad hoc networks (MANETs), wireless sensor networks (WSNs), and delay tolerant networks (DTNs). It is well known that mobility increases the capacity of MANETs by reducing the number of relays for routing, prolonging the lifespan of WSNs by using mobile nodes in place of bottleneck static sensors, and ensuring network connectivity in DTNs using mobile nodes to connect different parts of a disconnected network. Trajectory planning and the coordination of mobile nodes are two important design issues aiming to optimize or balance several measures,including delay, average number of relays, and moving distance. In this paper, we propose a new controlled mobility model with an expected polylogarithmic number of relays to achieve a good balance among several contradictory goals, including delay, the number of relays, and moving distance. The model is based on the small-world model where each static node has "short" link connections to its nearest neighbors and "long" link connections to other nodes following a certain probability distribution. Short links are regular wireless connections whereas long links are implemented using mobile nodes. Various issues are considered, including trade-offs between delay and average number of relays, selection of the number of mobilenodes, and selection of the number of long links. The effectiveness of the proposed model is evaluated analytically as well as through simulation.

  17. Feasibility of FDG PET/CT to monitor the response of axillary lymph node metastases to neoadjuvant chemotherapy in breast cancer patients

    Energy Technology Data Exchange (ETDEWEB)

    Straver, Marieke E.; Rutgers, Emiel J.T.; Peeters, Marie-Jeanne T.F.D.V. [Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Department of Surgical Oncology, Amsterdam (Netherlands); Aukema, Tjeerd S.; Olmos, Renato A.V.; Vogel, Wouter V. [Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Department of Nuclear Medicine, Amsterdam (Netherlands); Gilhuijs, Kenneth G.A. [Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Department of Radiology, Amsterdam (Netherlands); Schot, Margaret E. [Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Department of Medical Oncology, Amsterdam (Netherlands)

    2010-06-15

    The aim of this study was to assess the accuracy of {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT to visualize lymph node metastases before the start of neoadjuvant chemotherapy and to determine how often the visualization is sufficiently prominent to allow monitoring of the axillary response. Thirty-eight patients with invasive breast cancer of >3 cm and/or lymph node metastasis underwent FDG PET/CT before neoadjuvant chemotherapy. The results of the FDG PET/CT were compared with those from ultrasonography with fine-needle aspiration (FNA) cytology or sentinel node biopsy. Patients suitable for response monitoring of the axilla were defined as having either a maximum standardized uptake value (SUV{sub max}){>=}2.5 or a tumour to background ratio {>=}5 in the most intense lymph node. The sensitivity and specificity of FDG PET/CT in detecting axillary involvement were 97 and 100%, respectively. No difference existed between the SUV{sub max} of the primary tumour and that from the related most intense lymph node metastasis. Moreover, the mean tumour to background ratio was 90% higher in the lymph nodes compared to the primary tumour (p=0.006). Ninety-three per cent of the patients had sufficient uptake in the lymph nodes to qualify for subsequent response monitoring of the axilla. A considerable distinction in metabolic activity was observed between the different subtypes of breast cancer. The mean SUV{sub max} in lymph node metastases of oestrogen receptor (ER)-positive, triple-negative and human epidermal growth factor receptor 2 (HER2)-positive tumours was 6.6, 11.6 and 6.6, respectively. The high accuracy in visualizing lymph node metastases and the sufficiently high SUV{sub max} and tumour to background ratio at baseline suggest that it is feasible to monitor the axillary response with FDG PET/CT, especially in triple-negative tumours. (orig.)

  18. High expression of osteoglycin decreases the metastatic capability of mouse hepatocarcinoma Hca-F cells to lymph nodes

    Institute of Scientific and Technical Information of China (English)

    Xiaonan Cui; Bo Song; Li Hou; Zhiyi Wei; Jianwu Tang

    2008-01-01

    Osteoglycin, one of the matrix molecules, belongs to the small leucine-rich proteoglycan gene family and might play important roles in cell growth and differentiation and in pathological processes such as fibrosis and cancer growth.In this study, a eukaryotic expression plasmid pIRESpuro3 osteoglycin(+) was constructed and transfected into mouse hepatocarcinoma Hca-F cells to evaluate the contribution of osteoglycin to the malignant behavior of Hca-F. It was foundthat Hca-F cells transfected with pIRESpuro3 osteoglycin(+) showed significantly decreased potential for both migration and invasion. Furthermore, Hca-F cells transfected with osteoglycin showed decreased metastatic potential to peripheral lymph nodes. However, proliferation potential and adhesive capacity of Hca-F cells to different protein substrates were not influenced by osteoglycin transfection. In summary,high expression of osteoglycin decreases the metastatic capability of Hca-F to lymph nodes.

  19. 老年胃癌预后及生活质量与血小板衍化内皮细胞生长因子和淋巴结微转移的关系%Relationship of prognosis and quality of life with platelet derived endothelial cell growth factor and lymph node micrometastasis in aged patients with gastric carcinoma

    Institute of Scientific and Technical Information of China (English)

    栾复新; 王孟薇; 于国; 吕亚莉; 钟梅

    2004-01-01

    目的:研究老年胃癌术前活检标本血小板衍化内皮细胞生长因子(platelet drived endothelial cell growthfactor,PD-ECGF)表达和术后淋巴结微转移(lymph node micrometastasis,LNM)的检测与老年胃癌预后的关系.方法:采用免疫组化法检测了92例老年胃癌PD-ECGF和65例胃癌LNM的表达情况,并分析它们与胃癌临床病理因素关系及对预后影响.结果:PD-ECGF蛋白阳性表达率为51.87%,LNM阳性率为37.3%,且两者表达呈正相关(x2=5.33,P<0.05).PD-ECGF蛋白表达水平与肿瘤大小、组织分化程度、浸润深度、血管癌栓、淋巴结转移及TNM分期密切相关(秩和Hc=8.36~32.30,P<0.05~0.01),LNM与组织分化程度、浸润深度、TNM分期呈正相关(x2=16.82,15.60,16.40,P均<0.01).PD-ECGF、LNM的表达和胃癌预后、生活质量呈负相关(t=2.15,2.95,P均<0.01).结论:PD-ECGF表达和淋巴结微转移呈正相关,二者与胃癌生长、浸润转移关系密切,可作为估计老年胃癌预后和生活质量的重要指标.

  20. Recurrent ovarian cancer presenting in the right supraclavicular lymph node with isolated metastasis: a case report.

    Science.gov (United States)

    Tanaka, Tomohito; Ohmichi, Masahide

    2012-07-02

    The majority of ovarian cancer recurrences are in the abdomen. However, some cases relapse as isolated lymph node metastases, mostly in pelvic or para-aortic nodes. Peripheral isolated lymph node metastasis is rare. A 69-year-old Japanese woman had recurrent ovarian cancer presenting with isolated right supraclavicular lymph node metastasis. After surgical resection and combination chemotherapy with carboplatin and paclitaxel, her right supraclavicular lymph node completely regressed. Peripheral isolated lymph nodes, including right supraclavicular lymph node, can recur without a macroscopic abdominal lesion. Clinicians should carefully examine peripheral lymph nodes for recurrence.

  1. Recurrent ovarian cancer presenting in the right supraclavicular lymph node with isolated metastasis: a case report

    Directory of Open Access Journals (Sweden)

    Tanaka Tomohito

    2012-07-01

    Full Text Available Abstract Introduction The majority of ovarian cancer recurrences are in the abdomen. However, some cases relapse as isolated lymph node metastases, mostly in pelvic or para-aortic nodes. Peripheral isolated lymph node metastasis is rare. Case presentation A 69-year-old Japanese woman had recurrent ovarian cancer presenting with isolated right supraclavicular lymph node metastasis. After surgical resection and combination chemotherapy with carboplatin and paclitaxel, her right supraclavicular lymph node completely regressed. Conclusions Peripheral isolated lymph nodes, including right supraclavicular lymph node, can recur without a macroscopic abdominal lesion. Clinicians should carefully examine peripheral lymph nodes for recurrence.

  2. Information-based self-organization of sensor nodes of a sensor network

    Science.gov (United States)

    Ko, Teresa H.; Berry, Nina M.

    2011-09-20

    A sensor node detects a plurality of information-based events. The sensor node determines whether at least one other sensor node is an information neighbor of the sensor node based on at least a portion of the plurality of information-based events. The information neighbor has an overlapping field of view with the sensor node. The sensor node sends at least one communication to the at least one other sensor node that is an information neighbor of the sensor node in response to at least one information-based event of the plurality of information-based events.

  3. Simulation and analysis of node throughput using smart antenna in wireless mesh networks

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yong; WEI Yi-fei; ZHANG Li-kun; SONG Jun-de

    2007-01-01

    Smart antenna technology is introduced to wireless mesh networks. Smart antennas based wider-range access medium access control (MAC) protocol (SWAMP) is used as MAC protocol for IEEE 802.11 mesh networks in this study. The calculation method of node throughput in chain and arbitrary topology is proposed under nodes fairness guarantee. Network scale and interference among nodes are key factors that influence node throughput Node distribution pattern near the gateway also affects the node throughput. Experiment based on network simulator-2 (NS-2) simulation platform compares node throughput between smart antenna scenario and omni-antenna scenario. As smart antenna technology reduces the bottle collision domain, node throughput increases observably.

  4. A single cervical lymph node metastasis of malignant ameloblastoma.

    Science.gov (United States)

    Kim, Yoori; Choi, Sung-Weon; Lee, Jong-Ho; Ahn, Kang-Min

    2014-12-01

    Cervical node metastasis of malignant ameloblastoma is extremely rare. Because of its rarity, there is no standard treatment modality in a single lymph node metastasis in malignant ameloblastoma. Eleven patients of malignant ameloblastoma involving a single cervical lymph node metastasis and one new case were reviewed. Neck treatment was classified into neck dissection and simple excision. Local nodal recurrence, distant metastasis and follow-up periods were investigated. Eight patients were treated with neck dissection (group A) and four patients underwent a simple node excision (group B). Two patients in group A experienced multiple organ metastases such as liver and lung seven months and 13 years after neck dissection respectively. The other patients showed no recurrence and metastasis. In group B, there was no report of a regional neck recurrence and distant metastasis during follow-up of 1-7 years. Multiple nodes metastasis requires a radical neck dissection; however, simple excision with close follow-up may be used in a single node metastasis in malignant ameloblastoma. Copyright © 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  5. Neural node network and model, and method of teaching same

    Science.gov (United States)

    Parlos, Alexander G. (Inventor); Atiya, Amir F. (Inventor); Fernandez, Benito (Inventor); Tsai, Wei K. (Inventor); Chong, Kil T. (Inventor)

    1995-01-01

    The present invention is a fully connected feed forward network that includes at least one hidden layer 16. The hidden layer 16 includes nodes 20 in which the output of the node is fed back to that node as an input with a unit delay produced by a delay device 24 occurring in the feedback path 22 (local feedback). Each node within each layer also receives a delayed output (crosstalk) produced by a delay unit 36 from all the other nodes within the same layer 16. The node performs a transfer function operation based on the inputs from the previous layer and the delayed outputs. The network can be implemented as analog or digital or within a general purpose processor. Two teaching methods can be used: (1) back propagation of weight calculation that includes the local feedback and the crosstalk or (2) more preferably a feed forward gradient decent which immediately follows the output computations and which also includes the local feedback and the crosstalk. Subsequent to the gradient propagation, the weights can be normalized, thereby preventing convergence to a local optimum. Education of the network can be incremental both on and off-line. An educated network is suitable for modeling and controlling dynamic nonlinear systems and time series systems and predicting the outputs as well as hidden states and parameters. The educated network can also be further educated during on-line processing.

  6. Rapid identifying high-influence nodes in complex networks

    Science.gov (United States)

    Song, Bo; Jiang, Guo-Ping; Song, Yu-Rong; Xia, Ling-Ling

    2015-10-01

    A tiny fraction of influential individuals play a critical role in the dynamics on complex systems. Identifying the influential nodes in complex networks has theoretical and practical significance. Considering the uncertainties of network scale and topology, and the timeliness of dynamic behaviors in real networks, we propose a rapid identifying method (RIM) to find the fraction of high-influential nodes. Instead of ranking all nodes, our method only aims at ranking a small number of nodes in network. We set the high-influential nodes as initial spreaders, and evaluate the performance of RIM by the susceptible-infected-recovered (SIR) model. The simulations show that in different networks, RIM performs well on rapid identifying high-influential nodes, which is verified by typical ranking methods, such as degree, closeness, betweenness, and eigenvector centrality methods. Project supported by the National Natural Science Foundation of China (Grant Nos. 61374180 and 61373136), the Ministry of Education Research in the Humanities and Social Sciences Planning Fund Project, China (Grant No. 12YJAZH120), and the Six Projects Sponsoring Talent Summits of Jiangsu Province, China (Grant No. RLD201212).

  7. Influence of racemic higenamine on the sinus node.

    Science.gov (United States)

    Yu, Fengxia; Kong, Lingting; Wang, Shujuan

    2013-02-01

    The aim of this study was to explore the mechanism of racemic higenamine in the treatment of sick sinus syndrome (SSS). A total of 40 New Zealand rabbits were randomly divided into normal sinus node and damaged sinus node (SND) groups, and each group was randomly divided into treatment and control groups (n=10). The SND model was established by formaldehyde wet dressing of the sinus node area. The treatment groups were administered an intravenous infusion of 0.04 mg/kg racemic higenamine via the marginal ear vein within 5 min. The electrophysiological indicators of sinoatrial function, including the sinus node recovery time (SNRT), corrected sinus node recovery time (CSNRT), total sinoatrial conduction time (TSACT) and sinus cycle length (SCL), were determined before and 20 min after medication and the changes in these indicators were evaluated. The two control groups were administered 10 ml physiological saline. Following the administration of racemic higenamine, the SNRT, CSNRT, TSACT and SCL in the normal sinus node and SND groups were significantly shortened compared with those in the control groups (Pnode group (Pnode was statistically significant (Pnode self-discipline and improvement of sinoatrial and atrioventricular conduction function.

  8. Measures of node centrality in mobile social networks

    Science.gov (United States)

    Gao, Zhenxiang; Shi, Yan; Chen, Shanzhi

    2015-02-01

    Mobile social networks exploit human mobility and consequent device-to-device contact to opportunistically create data paths over time. While links in mobile social networks are time-varied and strongly impacted by human mobility, discovering influential nodes is one of the important issues for efficient information propagation in mobile social networks. Although traditional centrality definitions give metrics to identify the nodes with central positions in static binary networks, they cannot effectively identify the influential nodes for information propagation in mobile social networks. In this paper, we address the problems of discovering the influential nodes in mobile social networks. We first use the temporal evolution graph model which can more accurately capture the topology dynamics of the mobile social network over time. Based on the model, we explore human social relations and mobility patterns to redefine three common centrality metrics: degree centrality, closeness centrality and betweenness centrality. We then employ empirical traces to evaluate the benefits of the proposed centrality metrics, and discuss the predictability of nodes' global centrality ranking by nodes' local centrality ranking. Results demonstrate the efficiency of the proposed centrality metrics.

  9. Active Learning for Node Classification in Assortative and Disassortative Networks

    CERN Document Server

    Moore, Cristopher; Zhu, Yaojia; Rouquier, Jean-Baptiste; Lane, Terran

    2011-01-01

    In many real-world networks, nodes have class labels, attributes, or variables that affect the network's topology. If the topology of the network is known but the labels of the nodes are hidden, we would like to select a small subset of nodes such that, if we knew their labels, we could accurately predict the labels of all the other nodes. We develop an active learning algorithm for this problem which uses information-theoretic techniques to choose which nodes to explore. We test our algorithm on networks from three different domains: a social network, a network of English words that appear adjacently in a novel, and a marine food web. Our algorithm makes no initial assumptions about how the groups connect, and performs well even when faced with quite general types of network structure. In particular, we do not assume that nodes of the same class are more likely to be connected to each other---only that they connect to the rest of the network in similar ways.

  10. Sentinel Lymph Node Mapping In Gastric Cancer Surgery: Current Status

    Directory of Open Access Journals (Sweden)

    Bara Tivadar

    2016-12-01

    Full Text Available Lymphonodular metastases remain an important predictive and prognostic factor in gastric cancer development. The precise determination of the lymphonodular invasion stage can be made only by extended intraoperative lymphadenectomy and histopathological examination. But the main controversy is the usefulness of extended lymph dissection in early gastric cancer. This increases the duration of the surgery and the complications rate, and it is unnecessary without lymphonodular invasion. The identification of the sentinel lymph nodes has been successfully applied for some time in the precise detection of lymph nodes status in breast cancer, malignant melanoma and the use for gastric cancer patients has been a controversial issue. The good prognosis in early gastric cancer had been a surgery challenge, which led to the establishment of minimally invasive individualized treatment and acceptance of sentinel lymph node mapping. The dual-tracer method, submucosally administered endoscopically is also recommended in sentinel lymph node biopsy by laparoscopic approach. There are new sophisticated technologies for detecting sentinel lymph node such as: infrared ray endoscopy, florescence imaging and near-infrared technology, carbon nanoparticles, which will open new perspectives in sentinel lymph nodes mapping.

  11. Sentinel lymph node biopsy indications and controversies in breast cancer.

    Science.gov (United States)

    Wiatrek, Rebecca; Kruper, Laura

    2011-05-01

    Sentinel lymph node biopsy (SLNB) has become the standard of care for early breast cancer. Its use in breast cancer has been evaluated in several randomized controlled trials and validated in multiple prospective studies. Additionally, it has been verified that SLNB has decreased morbidity when compared to axillary lymph node dissection (ALND). The technique used to perform sentinel lymph node mapping was also evaluated in multiple studies and the accuracy rate increases when radiocolloid and blue dye are used in combination. As SLNB became more accepted, contraindications were delineated and are still debated. Patients who have clinically positive lymph nodes or core biopsy-proven positive lymph nodes should not have SLNB, but should have an ALND as their staging procedure. The safety of SLNB in pregnant patients is not fully established. However, patients with multifocal or multicentric breast cancer and patients having neoadjuvant chemotherapy are considered candidates for SLNB. However, the details of which specific neoadjuvant patients should have SLNB are currently being evaluated in a randomized controlled trial. Patients with ductal carcinoma in situ (DCIS) benefit from SLNB when mastectomy is planned and when there is a high clinical suspicion of invasion. With the advent of SLNB, pathologic review of breast cancer lymph nodes has evolved. The significance of occult metastasis in SLNB patients is currently being debated. Additionally, the most controversial subject with regards to SLNB is determining which patients with positive SLNs benefit from further axillary dissection.

  12. Node Augmentation Technique in Bayesian Network Evidence Analysis and Marshaling

    Energy Technology Data Exchange (ETDEWEB)

    Keselman, Dmitry [Los Alamos National Laboratory; Tompkins, George H [Los Alamos National Laboratory; Leishman, Deborah A [Los Alamos National Laboratory

    2010-01-01

    Given a Bayesian network, sensitivity analysis is an important activity. This paper begins by describing a network augmentation technique which can simplifY the analysis. Next, we present two techniques which allow the user to determination the probability distribution of a hypothesis node under conditions of uncertain evidence; i.e. the state of an evidence node or nodes is described by a user specified probability distribution. Finally, we conclude with a discussion of three criteria for ranking evidence nodes based on their influence on a hypothesis node. All of these techniques have been used in conjunction with a commercial software package. A Bayesian network based on a directed acyclic graph (DAG) G is a graphical representation of a system of random variables that satisfies the following Markov property: any node (random variable) is independent of its non-descendants given the state of all its parents (Neapolitan, 2004). For simplicities sake, we consider only discrete variables with a finite number of states, though most of the conclusions may be generalized.

  13. Probabilistic Analysis on Connectivity for Sensor Grids with Unreliable Nodes

    Institute of Scientific and Technical Information of China (English)

    WANG Gaocai; LIN Chuang; CHEN Jianer

    2006-01-01

    This paper mainly investigates the connectivity of the unreliable sensor grid network. We consider an unreliable sensor grid network with mn nodes placed in a certain planar area A, and we assume that each node has independent failure probability p and has the same transmission range R. This paper presents a new method for calculating the connectivity probability of the network, which uses thorough mathematical methods to derive the relationship among the network connectivity probability, the probability that a node is "failed"(not active), the numbers of node, and the node's transmission range in unreliable sensor networks. Our approach is more useful and efficient for given problem and conditions. Such as the numerical calculating results indicate that, for a 100×100 size sensor network, if node failure probability is bounded 0.5%, even if the transmission range is small (such as R=10), we can still maintain very high connectivity probability (reach 95.8%). On the other hand, the simulation results show that building high connectivity probability is entirely possible on unreliable sensor grid networks.

  14. Mobility and Cooperation to Thwart Node Capture Attacks in MANETs

    Directory of Open Access Journals (Sweden)

    Mauro Conti

    2009-01-01

    Full Text Available The nature of mobile ad hoc networks (MANETs, often unattended, makes this type of networks subject to some unique security issues. In particular, one of the most vexing problem for MANETs security is the node capture attack: an adversary can capture a node from the network eventually acquiring all the cryptographic material stored in it. Further, the captured node can be reprogrammed by the adversary and redeployed in the network in order to perform malicious activities. In this paper, we address the node capture attack in MANETs. We start from the intuition that mobility, in conjunction with a reduced amount of local cooperation, helps computing effectively and with a limited resource usage network global security properties. Then, we develop this intuition and use it to design a mechanism to detect the node capture attack. We support our proposal with a wide set of experiments showing that mobile networks can leverage mobility to compute global security properties, like node capture detection, with a small overhead.

  15. Histological step sectioning of pelvic lymph nodes increases the number of identified lymph node metastases

    DEFF Research Database (Denmark)

    Engvad, Birte; Poulsen, Mads H; Staun, Pia W;

    2014-01-01

    Pathological examinations of lymph nodes (LN) in prostate cancer patients are handled differently at various institutions. The objective of this study is to provide means to improve the guidelines by examining the impact of step sectioning on LN status in patients with intermediate and high......-risk prostate cancer. Two hundred ten patients who awaited curative indented therapy were included. We first performed a standard pathological examination of the LN, followed by an extended pathological examination of the patients who were LN negative in the standard examination. The extended pathological...... indicate that an extended pathological examination of LN will improve the staging of intermediate- and high-risk prostate cancer patients; however, we acknowledge that it is both costly and time consuming. We do not recommend the use of cytokeratin staining in routine staining because...

  16. Medical image archive node simulation and architecture

    Science.gov (United States)

    Chiang, Ted T.; Tang, Yau-Kuo

    1996-05-01

    access time, number of drives, number of exams per patient, number of Central Processing Units, patient grouping, and priority impacts. The MIADS, which could be a key component of a broader data repository system, will be able to communicate with and obtain data from existing hospital information systems. We will discuss the external interfaces enabling MIADS to communicate with and obtain data from existing Radiology Information Systems such as the Picture Archiving and Communication System (PACS). Our system design encompasses the broader aspects of the archive node, which could include multimedia data such as image, audio, video, and free text data. This system is designed to be integrated with current hospital PACS through a Digital Imaging and Communications in Medicine interface. However, the system can also be accessed through the Internet using Hypertext Transport Protocol or Simple File Transport Protocol. Our design and simulation work will be key to implementing a successful, scalable medical image archive and distribution system.

  17. Virtual lymph node analysis to evaluate axillary lymph node coverage provided by tangential breast irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Park, Shin Hyung; Kim, Jae Chul; Lee, Jeong Eun; Park, In Kyu [Dept.of Radiation Oncology, Kyungpook National University Hospital, Daegu(Korea, Republic of)

    2015-03-15

    To investigate the coverage of axillary lymph node with tangential breast irradiation fields by using virtual lymph node (LN) analysis. Forty-eight women who were treated with whole breast irradiation after breast-conserving surgery were analyzed. The axillary and breast volumes were delineated according to the Radiation Therapy Oncology Group (RTOG) contouring atlas. To generate virtual LN contours, preoperative fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans with identifiable LN were fused with the CT scans, and the virtual LN contour were delineated on the CT. The median level I and II axillary volume coverage percentages at the VD95% line were 33.5% (range, 5.3% to 90.4%) and 0.6% (range, 0.0% to 14.6%), respectively. Thirty-one LNs in 18 patients were delineated (26 in level I and 5 in level II). In the level I axilla, 84.6% of virtual LNs were encompassed by the 95% isodose line. In the level II axilla, by contrast, none of the virtual LNs were encompassed by the 95% isodose volumes. There was a substantial discrepancy between the RTOG contouring atlas-based axillary volume analysis and the virtual LN analysis, especially for the level I axillary coverage. The axillary volume coverage was associated with the body mass index (BMI) and breast volume. The tangential breast irradiation did not deliver adequate therapeutic doses to the axillary region, particularly those in the level II axilla. Patients with small breast volumes or lower BMI showed reduced axillary coverage from the tangential breast fields. For axillary LN irradiation, individualized anatomy-based radiation fields for patients would be necessary.

  18. Utilities:Water:Sewer Line Nodes at Pipe Spring National Monument, Arizona (Utilities.gdb:Water:sewer_node)

    Data.gov (United States)

    National Park Service, Department of the Interior — This feature class represents sewer line nodes at Pipe Spring National Monument, Arizona. The data were collected using Trimble Global Positioning System (GPS) units...

  19. Utilities:Other:Telephone Nodes at Pipe Spring National Monument, Arizona (Utilities.gdb:Other:telephone_node)

    Data.gov (United States)

    National Park Service, Department of the Interior — This feature class represent the nodes of the telephone lines at Pipe Spring National Monument, Arizona. The utility pipelines were collected by a Trimble GeoXT GPS...

  20. Ascending colon cancer with synchronous external iliac and inguinal lymph node metastases but without regional lymph node metastasis: a case report and brief literature review.

    Science.gov (United States)

    Kitano, Yuki; Kuramoto, Masafumi; Masuda, Toshiro; Kuroda, Daisuke; Yamamoto, Kenichiro; Ikeshima, Satoshi; Iyama, Ken-Ichi; Shimada, Shinya; Baba, Hideo

    2017-12-01

    Lymph node metastasis to the iliac or inguinal region of colon cancer is extremely rare. We experienced a case of ascending colon cancer with synchronous isolated right external iliac and inguinal lymph node metastases but without any regional lymph node metastasis. An 83-year-old woman was admitted to our hospital due to anemia. Colonoscopy and computed tomography revealed an ascending colon cancer and also right external iliac and inguinal lymph node swelling. Further examination by F-deoxyglucose positron emission tomography strongly suggested that these lymph nodes were metastatic. Right hemicolectomy with lymph node dissection along the superior mesenteric artery, and right external iliac and inguinal lymph node dissection were performed. Histological examination revealed that both lymph nodes were metastasized from colon cancer, and there was no evidence of regional lymph node metastasis. The patient has shown no sign of recurrence at 27 months after surgery.

  1. Complexity of Reducing the Delay between Two Nodes by Node-based and Edge-based Upgrading Strategies

    Institute of Scientific and Technical Information of China (English)

    Xiao-guang Yang; Jian-zhong Zhang

    2004-01-01

    For a pair of nodes s, t in an undirected graph G =(V,A) and a given level U of allowable delay, we would like to modify the network by node-based or edge-based upgrading strategies to make the delay between s and t not greater than U. In this paper, we present some NP-hard results for the delay improvement problems.

  2. Methods and apparatus using commutative error detection values for fault isolation in multiple node computers

    Science.gov (United States)

    Almasi, Gheorghe [Ardsley, NY; Blumrich, Matthias Augustin [Ridgefield, CT; Chen, Dong [Croton-On-Hudson, NY; Coteus, Paul [Yorktown, NY; Gara, Alan [Mount Kisco, NY; Giampapa, Mark E [Irvington, NY; Heidelberger, Philip [Cortlandt Manor, NY; Hoenicke, Dirk I [Ossining, NY; Singh, Sarabjeet [Mississauga, CA; Steinmacher-Burow, Burkhard D [Wernau, DE; Takken, Todd [Brewster, NY; Vranas, Pavlos [Bedford Hills, NY

    2008-06-03

    Methods and apparatus perform fault isolation in multiple node computing systems using commutative error detection values for--example, checksums--to identify and to isolate faulty nodes. When information associated with a reproducible portion of a computer program is injected into a network by a node, a commutative error detection value is calculated. At intervals, node fault detection apparatus associated with the multiple node computer system retrieve commutative error detection values associated with the node and stores them in memory. When the computer program is executed again by the multiple node computer system, new commutative error detection values are created and stored in memory. The node fault detection apparatus identifies faulty nodes by comparing commutative error detection values associated with reproducible portions of the application program generated by a particular node from different runs of the application program. Differences in values indicate a possible faulty node.

  3. Predictive Factors for Nonsentinel Lymph Node Metastasis in Patients With Positive Sentinel Lymph Nodes After Neoadjuvant Chemotherapy: Nomogram for Predicting Nonsentinel Lymph Node Metastasis.

    Science.gov (United States)

    Ryu, Jai Min; Lee, Se Kyung; Kim, Ji Young; Yu, Jonghan; Kim, Seok Won; Lee, Jeong Eon; Han, Se Hwan; Jung, Yong Sik; Nam, Seok Jin

    2017-04-06

    Axillary lymph node (ALN) status is an important prognostic factor for breast cancer patients. With increasing numbers of patients undergoing neoadjuvant chemotherapy (NAC), issues concerning sentinel lymph node biopsy (SLNB) after NAC have emerged. We analyzed the clinicopathologic features and developed a nomogram to predict the possibility of nonsentinel lymph node (NSLN) metastases in patients with positive SLNs after NAC. A retrospective medical record review was performed of 140 patients who had had clinically positive ALNs at presentation, had a positive SLN after NAC on subsequent SLNB, and undergone axillary lymph node dissection (ALND) from 2008 to 2014. On multivariate stepwise logistic regression analysis, pathologic T stage, lymphovascular invasion, SLN metastasis size, and number of positive SLN metastases were independent predictors for NSLN metastases (P Samsung Medical Center NAC nomogram was developed to predict the likelihood of additional positive NSLNs. The Samsung Medical Center NAC nomogram could provide information to surgeons regarding whether to perform additional ALND when the permanent biopsy revealed positive findings, although the intraoperative SLNB findings were negative. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Multiple-node basin stability in complex dynamical networks

    Science.gov (United States)

    Mitra, Chiranjit; Choudhary, Anshul; Sinha, Sudeshna; Kurths, Jürgen; Donner, Reik V.

    2017-03-01

    Dynamical entities interacting with each other on complex networks often exhibit multistability. The stability of a desired steady regime (e.g., a synchronized state) to large perturbations is critical in the operation of many real-world networked dynamical systems such as ecosystems, power grids, the human brain, etc. This necessitates the development of appropriate quantifiers of stability of multiple stable states of such systems. Motivated by the concept of basin stability (BS) [P. J. Menck et al., Nat. Phys. 9, 89 (2013), 10.1038/nphys2516], we propose here the general framework of multiple-node basin stability for gauging the global stability and robustness of networked dynamical systems in response to nonlocal perturbations simultaneously affecting multiple nodes of a system. The framework of multiple-node BS provides an estimate of the critical number of nodes that, when simultaneously perturbed, significantly reduce the capacity of the system to return to the desired stable state. Further, this methodology can be applied to estimate the minimum number of nodes of the network to be controlled or safeguarded from external perturbations to ensure proper operation of the system. Multiple-node BS can also be utilized for probing the influence of spatially localized perturbations or targeted attacks to specific parts of a network. We demonstrate the potential of multiple-node BS in assessing the stability of the synchronized state in a deterministic scale-free network of Rössler oscillators and a conceptual model of the power grid of the United Kingdom with second-order Kuramoto-type nodal dynamics.

  5. Popliteal lymph node metastasis of tibial osteoblastic osteosarcoma.

    Science.gov (United States)

    Dirik, Yalın; Çınar, Arda; Yumrukçal, Feridun; Eralp, Levent

    2014-01-01

    We report a case with lymph node metastasis of osteosarcoma, which is a rare entity in comparison to hematogeneous lung or bone metastasis. Twenty-seven years old male patient referred to our clinic complaining of ongoing left knee pain and swelling since one month without a history of prior trauma. Magnetic resonance imaging (MRI) revealed a mass of malignant nature which causes more prominent expansion and destruction of the bone distally with periosteal reaction. A lymphadenomegaly 16mm×13mm in diameter was also present in the popliteal fossa having the same signal pattern with the primary lesion. Thirteen weeks following the first referral of the patient, wide resection and reconstruction with modular tumor prosthesis was performed. Popliteal lymph node was excised through the same incision. Pathologic examination of the resected speciman reported osteoblastic osteosarcoma. The lymph node extirpated from the popliteal fossa was reported to be a metastasis of the primary tumor. Osteosarcoma of the long bones is the most common primary malignant bone neoplasm of both childhood and adulthood. Osteosarcomas commonly metastasize hematogeneously to the lungs and bones. Lymph node metastasis is a rare entity. Similar studies report rates between 2.3% and 4%. It is not clearly explained, how lymph node metastasis in osteosarcoma occurs despite lack of lymphatic drainage in normal cortical and spongious bone. Lymph node metastasis of osteosarcoma is a rare entity and metastatic patterns could not be clearly explained. On the other hand, the effects of lymph node metastasis on prognosis are also not clearly defined and further studies are needed. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  6. Evaluation of lymph node reactivity in differentiated thyroid carcinoma

    Directory of Open Access Journals (Sweden)

    Ali Amar

    1999-05-01

    Full Text Available CONTEXT: The development of metastases is the most notable characteristic of malignant neoplasias. The filter function of lymph nodes, which led to the idea of including lymphatic treatment in surgical management of metastases. OBJECTIVES: To evaluate morphological alterations in neck nodes in the presence of differentiated thyroid carcinoma (DTC: hyperplasia, histiocytosis, desmoplasia, capsular rupture, necrosis and their relation to the biological behavior of these neoplasias. DESIGN: Retrospective study. SETTING: University referral unit. PARTICIPANTS: 98 DTC patients, from 1977 to 1992, 18 cases were selected for histological analyses, of which 14 were female and 4 males, with an average age of 50.2 years. From these cases, 290 lymph nodes were analyzed (81 with metastasis, with an average of 16 lymph nodes/patient. MAIN MEASUREMENTS: Morphological evaluation of paraffin cuts stained by HE was done using an optical microscope, looking for presence of the abovementioned neoplasias and their UICC-TNM (1997 staging. RESULTS: Sinus histiocytosis was 2.4 times more frequent in the absence of lymph node metastasis (pNo. Disease recurrence occurred in 5 patients, all of whom were more than 40 years old (p= 0.24 and 4 of whom had necrosis (p= 0.02. Six patients with predominance of paracortical hyperplasia (p= 0.02 did not show as much relapse into disease as those with less than 6 metastasis lymph nodes (p= 0.009. CONCLUSIONS: The presence of paracortical hyperplasia is associated with a better prognosis. The existence of necrosis or metastasis in more than 6 lymph nodes in patients over 40 years of age is related to higher risk of relapse of disease in DTC.

  7. Cost analysis of sentinel lymph node biopsy in melanoma.

    Science.gov (United States)

    Martínez-Menchón, T; Sánchez-Pedreño, P; Martínez-Escribano, J; Corbalán-Vélez, R; Martínez-Barba, E

    2015-04-01

    Sentinel lymph node biopsy (SLNB) is the most useful tool for node staging in melanoma. SLNB facilitates selective dissection of lymph nodes, that is, the performance of lymphadenectomy only in patients with sentinel nodes positive for metastasis. Our aim was to assess the cost of SLNB, given that this procedure has become the standard of care for patients with melanoma and must be performed whenever patients are to be enrolled in clinical trials. Furthermore, the literature on the economic impact of SLNB in Spain is scarce. From 2007 to 2010, we prospectively collected data for 100 patients undergoing SLNB followed by transhilar bivalving and multiple-level sectioning of the node for histology. Our estimation of the cost of the technique was based on official pricing and fee schedules for the Spanish region of Murcia. The rate of node-positive cases in our series was 20%, and the mean number of nodes biopsied was 1.96; 44% of the patients in the series had thin melanomas. The total cost was estimated at between €9486.57 and €10471.29. Histopathology accounted for a considerable portion of the cost (€5769.36). The cost of SLNB is high, consistent with amounts described for a US setting. Optimal use of SLNB will come with the increasingly appropriate selection of patients who should undergo the procedure and the standardization of a protocol for histopathologic evaluation that is both sensitive and easy to perform. Copyright © 2014 Elsevier España, S.L.U. and AEDV. All rights reserved.

  8. ВИКОРИСТАННЯ ПЛАТФОРМИ NODE.JS ДЛЯ РОЗРОБКИ СУЧАСНИХ ВЕБ-СЕРВІСІВ

    OpenAIRE

    Остапенко, Сергій Олександрович; Прищепа, Татьяна Алексеевна

    2016-01-01

    Usage of Node.js platform for web-application development             Node.js - platform for developing high-load server-side web applications. Synchronous and asynchronous input - output model. Advantages of using technology for developing multi-user applications. Common mistakes in the use of Node.js.  Huge growth in popularity of technology.

  9. Nodal ratio of positive to excised nodes, but not number of positive lymph nodes is better to predict group to avoid chemotherapy among postmenopausal ER-positive, lymph node-positive T1-T2 breast cancer patients

    Directory of Open Access Journals (Sweden)

    X Q Jia

    2015-01-01

    Conclusion: This retrospective analysis demonstrates that NR of positive to excised nodes, but not number of positive lymph nodes is better to predict group to avoid chemotherapy among postmenopausal ER-positive, lymph node-positive T1-T2 breast cancer patients.

  10. Impact of clinical pharmacy interventions on medication error nodes.

    Science.gov (United States)

    Chamoun, Nibal R; Zeenny, Rony; Mansour, Hanine

    2016-12-01

    Background Pharmacists' involvement in patient care has improved the quality of care and reduced medication errors. However, this has required a lot of work that could not have been accomplished without documentation of interventions. Several means of documenting errors have been proposed in the literature but without a consistent comprehensive process. Recently, the American College of Clinical Pharmacy (ACCP) recognized that pharmacy practice lacks a consistent process for direct patient care and discussed several options for a pharmaceutical care plan, essentially encompassing medication therapy assessment, development and implementation of a pharmaceutical care plan and finally evaluation of the outcome. Therefore, as per the recommendations of ACCP, we sought to retrospectively analyze interventions by grouping them according to medication related problems (MRP) and their nodes such as prescribing; administering; monitoring; documenting and dispensing. Objective The aim of this study is to report interventions according to medication error (ME) nodes and show the impact of pharmacy interventions in reducing MRPs. Setting The study was conducted at the cardiology and infectious diseases services at a teaching hospital located in Beirut, Lebanon. Methods Intervention documentation was completed by pharmacy students on infectious diseases and cardiology rotations then reviewed by clinical pharmacists with respective specialties. Before data analysis, a new pharmacy reporting sheet was developed in order to link interventions according to MRP. Then, MRPs were grouped in the five ME nodes. During the documentation process, whether MRP had reached the patient or not may have not been reported which prevented the classification to the corresponding medication error nodes as ME. Main outcome Reduction in medication related problems across all ME nodes. Results A total of n = 1174 interventions were documented. N = 1091 interventions were classified as MRPs

  11. Breast Cancer Subtype as a Predictor of Lymph Node Metastasis according to the SEER Registry

    Science.gov (United States)

    Bhatia, Jay K.; Metzger, Daniel; Ashamalla, Hani; Katsoulakis, Evangelia

    2015-01-01

    Purpose Breast cancer subtype correlates with response to systemic therapy and overall survival (OS), but its impact on lymphatic spread is incompletely understood. In this study, we used the Surveillance, Epidemiology, and End Results registry to assess whether the subtype can predict the presence of nodal metastasis or advanced nodal stage in breast cancer. Methods A total of 7,274 eligible patients diagnosed with T1-3 infiltrating ductal carcinoma with known estrogen or progesterone hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status, who underwent surgical excision of the primary tumor and pathologic lymph node evaluation, were included in this analysis. Patients were categorized into four breast cancer subtypes: HR+/HER2-; HR+/HER2+; HR-/HER2+; and HR-/HER2-. Binary logistic regression analysis was used to determine whether breast cancer subtype, tumor size, tumor grade, patient race, and patient age at diagnosis are independently predictive of lymph node positivity or advanced nodal stage. The Pearson chi-square test was used to determine whether progesterone receptor (PR) status had an impact on the incidence of lymph node positivity in estrogen receptor (ER) positive patients. Results Independent predictors of nodal positivity included breast cancer subtype (p=0.040), tumor size (p<0.001), tumor grade (p<0.001), and patient age (p<0.001), whereas only tumor size (p<0.001), grade (p=0.001), and patient age (p=0.005) predicted advanced nodal stage. Triple-negative cancers had a significantly lower risk of nodal positivity than the HR+/HER2- subtype (odds ratio, 0.686; p=0.004), but no other significant differences between subtypes were observed. There was also no difference in lymph node positivity between PR+ and PR- tumors amongst ER+/HER2- (p=0.228) or ER+/HER2+ tumors (p=0.713). Conclusion The HR+/HER2-breast cancer subtype has a higher rate of lymph node involvement at diagnosis than the triple-negative subtype. These

  12. Malicious Nodes Detection in MANETs: Behavioral Analysis Approach

    Directory of Open Access Journals (Sweden)

    Yaser Khamayseh

    2012-01-01

    Full Text Available The increased popularity and usage of wireless technologies has opened the doors for new emerging applications in the domain of networking. One emerging and promising areas is the domain of Mobile Ad Hoc Networks (MANETs. A mobile ad hoc network is a collection of wireless mobile nodes that form a dynamic network without the need for infrastructure or centralized points.   The dynamic nature of ad hoc networks presents many security challenges. Secure routing is a promising area for achieving better security for the network by protecting the routing protocols against malicious attacks. Several secure routing protocols have been proposed in the literatures that were successful in avoiding and preventing some types of security attacks in MANETs.    However, MANETs are still vulnerable to other types of attacks. Hence, there is a need for introducing an efficient mechanism to detect malicious nodes.   In this paper, a new mechanism is proposed that improves the performance of routing protocol against the malicious attacks. Since a malicious node behaves in abnormal ways, this mechanism proposes observing nodes behavior such as nodes’ mobility, and avoiding communication through these nodes which may lead to more secure routing.

  13. Algorithm of simulation time synchronization over large-scale nodes

    Institute of Scientific and Technical Information of China (English)

    ZHAO QinPing; ZHOU Zhong; Lü Fang

    2008-01-01

    In distributed simulation, there is no uniform physical clock. And delay cannot be estimated because of jitter. So simulation time synchronization is essential for the event consistency among nodes. This paper investigates time synchronization algorithms over large-scale distributed nodes, analyzes LBTS (lower bound time stamp) computation model described in IEEE HLA standard, and then presents a grouped LBTS model. In fact, there is a default premise for existing algorithms that control packets must be delivered via reliable transportation. Although, a theorem of time synchronization message's reliability is proposed, which proves that only those control messages that constrain time advance need reliability. It breaks out the default premise for reliability. Then multicast is introduced into the transmission of control messages, and algorithm MCTS (multi-node coordination time synchronization) is proposed based on multicast. MCTS not only promotes the time advance efficiency, but also reduces the occupied network bandwidth. Experiment results demonstrate that the algorithm is better than others in both time advance speed and occupied network bandwidth. Its time advance speed is about 50 times per second when there are 1000 nodes, approximately equal to that of similar systems when there are 100 nodes.

  14. Automatic detection and segmentation of lymph nodes from CT data.

    Science.gov (United States)

    Barbu, Adrian; Suehling, Michael; Xu, Xun; Liu, David; Zhou, S Kevin; Comaniciu, Dorin

    2012-02-01

    Lymph nodes are assessed routinely in clinical practice and their size is followed throughout radiation or chemotherapy to monitor the effectiveness of cancer treatment. This paper presents a robust learning-based method for automatic detection and segmentation of solid lymph nodes from CT data, with the following contributions. First, it presents a learning based approach to solid lymph node detection that relies on marginal space learning to achieve great speedup with virtually no loss in accuracy. Second, it presents a computationally efficient segmentation method for solid lymph nodes (LN). Third, it introduces two new sets of features that are effective for LN detection, one that self-aligns to high gradients and another set obtained from the segmentation result. The method is evaluated for axillary LN detection on 131 volumes containing 371 LN, yielding a 83.0% detection rate with 1.0 false positive per volume. It is further evaluated for pelvic and abdominal LN detection on 54 volumes containing 569 LN, yielding a 80.0% detection rate with 3.2 false positives per volume. The running time is 5-20 s per volume for axillary areas and 15-40 s for pelvic. An added benefit of the method is the capability to detect and segment conglomerated lymph nodes.

  15. Boosting Nodes for Improving the Spread of Influence

    CERN Document Server

    Liontis, Konstantinos

    2016-01-01

    Information diffusion in networks has received a lot of recent attention. Most previous work addresses the influence maximization problem of selecting an appropriate set of seed nodes to initiate the diffusion process so that the largest number of nodes is reached. Since the seed selection problem is NP hard, most solutions are sub-optimal. Furthermore, there may be settings in which the seed nodes are predetermined. Thus, a natural question that arise is: given a set of seed nodes, can we select a small set of nodes such that if we improve their reaction to the diffusion process, the largest increase in diffusion spread is achieved? We call this problem, the boost set selection problem. In this paper, we formalize this problem, study its complexity and propose appropriate algorithms. We also evaluate the effect of boosting in a number of real networks and report the increase of influence spread achieved for different seed sets, time limits in the diffusion process and other diffusion parameters.

  16. Data acquisition remote node powered over the communications optical fiber

    Energy Technology Data Exchange (ETDEWEB)

    Batista, Antonio J.N., E-mail: toquim@ipfn.tecnico.ulisboa.pt; Sousa, Jorge; Gonçalves, Bruno

    2015-10-15

    Large nuclear fusion reactors, like ITER, will have harsh electromagnetic environments nearby the machine. Foreseeing the necessity for special data acquisition remote nodes, on difficult access locations and as close as possible to the experimental devices, motivated the system design. The architecture is based on the power-over-fiber technology recent advancements and respective implementation aim is to attain a proof of concept for the fusion technology field and others, e.g., high energy physics, industry, etc. The design intends the replacement of traditional copper cables and power supplies, vulnerable to electromagnetic interference, by the communications optical fiber of the data acquisition remote node. Optical fibers provide galvanic isolation, immunity to noisy electromagnetic environments and simultaneously can supply power to the remote node electronics. System architecture uses a laser power converter (array of photovoltaic cells) to convert the laser light, from the optical fiber, into electricity. The generated electrical power is enough for powering the remote node electronics and optoelectronics, such as an ADC, a low power FPGA and an optical transmitter. The laser power converter is also used as the communications receiver and from which the acquisition clock is recovered, providing synchronism between remote data acquisition nodes. Descriptions of the system architecture, tested implementations and future improvements are presented.

  17. Optimal Node Placement in Underwater Acoustic Sensor Network

    KAUST Repository

    Felemban, Muhamad

    2011-10-01

    Almost 70% of planet Earth is covered by water. A large percentage of underwater environment is unexplored. In the past two decades, there has been an increase in the interest of exploring and monitoring underwater life among scientists and in industry. Underwater operations are extremely difficult due to the lack of cheap and efficient means. Recently, Wireless Sensor Networks have been introduced in underwater environment applications. However, underwater communication via acoustic waves is subject to several performance limitations, which makes the relevant research issues very different from those on land. In this thesis, we investigate node placement for building an initial Underwater Wireless Sensor Network infrastructure. Firstly, we formulated the problem into a nonlinear mathematic program with objectives of minimizing the total transmission loss under a given number of sensor nodes and targeted volume. We conducted experiments to verify the proposed formulation, which is solved using Matlab optimization tool. We represented each node with a truncated octahedron to fill out the 3D space. The truncated octahedrons are tiled in the 3D space with each node in the center where locations of the nodes are given using 3D coordinates. Results are supported using ns-3 simulator. Results from simulation are consistent with the obtained results from mathematical model with less than 10% error.

  18. Network structure exploration in networks with node attributes

    Science.gov (United States)

    Chen, Yi; Wang, Xiaolong; Bu, Junzhao; Tang, Buzhou; Xiang, Xin

    2016-05-01

    Complex networks provide a powerful way to represent complex systems and have been widely studied during the past several years. One of the most important tasks of network analysis is to detect structures (also called structural regularities) embedded in networks by determining group number and group partition. Most of network structure exploration models only consider network links. However, in real world networks, nodes may have attributes that are useful for network structure exploration. In this paper, we propose a novel Bayesian nonparametric (BNP) model to explore structural regularities in networks with node attributes, called Bayesian nonparametric attribute (BNPA) model. This model does not only take full advantage of both links between nodes and node attributes for group partition via shared hidden variables, but also determine group number automatically via the Bayesian nonparametric theory. Experiments conducted on a number of real and synthetic networks show that our BNPA model is able to automatically explore structural regularities in networks with node attributes and is competitive with other state-of-the-art models.

  19. Modeling lymphocyte homing and encounters in lymph nodes

    Directory of Open Access Journals (Sweden)

    Bernaschi Massimo

    2009-11-01

    Full Text Available Abstract Background The efficiency of lymph nodes depends on tissue structure and organization, which allow the coordination of lymphocyte traffic. Despite their essential role, our understanding of lymph node specific mechanisms is still incomplete and currently a topic of intense research. Results In this paper, we present a hybrid discrete/continuous model of the lymph node, accounting for differences in cell velocity and chemotactic response, influenced by the spatial compartmentalization of the lymph node and the regulation of cells migration, encounter, and antigen presentation during the inflammation process. Conclusion Our model reproduces the correct timing of an immune response, including the observed time delay between duplication of T helper cells and duplication of B cells in response to antigen exposure. Furthermore, we investigate the consequences of the absence of dendritic cells at different times during infection, and the dependence of system dynamics on the regulation of lymphocyte exit from lymph nodes. In both cases, the model predicts the emergence of an impaired immune response, i.e., the response is significantly reduced in magnitude. Dendritic cell removal is also shown to delay the response time with respect to normal conditions.

  20. Wireless and Powerless Sensing Node System Developed for Monitoring Motors

    Directory of Open Access Journals (Sweden)

    Dasheng Lee

    2008-08-01

    Full Text Available Reliability and maintainability of tooling systems can be improved through condition monitoring of motors. However, it is difficult to deploy sensor nodes due to the harsh environment of industrial plants. Sensor cables are easily damaged, which renders the monitoring system deployed to assure the machine’s reliability itself unreliable. A wireless and powerless sensing node integrated with a MEMS (Micro Electro-Mechanical System sensor, a signal processor, a communication module, and a self-powered generator was developed in this study for implementation of an easily mounted network sensor for monitoring motors. A specially designed communication module transmits a sequence of electromagnetic (EM pulses in response to the sensor signals. The EM pulses can penetrate through the machine’s metal case and delivers signals from the sensor inside the motor to the external data acquisition center. By using induction power, which is generated by the motor’s shaft rotation, the sensor node is self-sustaining; therefore, no power line is required. A monitoring system, equipped with novel sensing nodes, was constructed to test its performance. The test results illustrate that, the novel sensing node developed in this study can effectively enhance the reliability of the motor monitoring system and it is expected to be a valuable technology, which will be available to the plant for implementation in a reliable motor management program.

  1. Optimal Node Grouping for Water Distribution System Demand Estimation

    Directory of Open Access Journals (Sweden)

    Donghwi Jung

    2016-04-01

    Full Text Available Real-time state estimation is defined as the process of calculating the state variable of interest in real time not being directly measured. In a water distribution system (WDS, nodal demands are often considered as the state variable (i.e., unknown variable and can be estimated using nodal pressures and pipe flow rates measured at sensors installed throughout the system. Nodes are often grouped for aggregation to decrease the number of unknowns (demands in the WDS demand estimation problem. This study proposes an optimal node grouping model to maximize the real-time WDS demand estimation accuracy. This Kalman filter-based demand estimation method is linked with a genetic algorithm for node group optimization. The modified Austin network demand is estimated to demonstrate the proposed model. True demands and field measurements are synthetically generated using a hydraulic model of the study network. Accordingly, the optimal node groups identified by the proposed model reduce the total root-mean-square error of the estimated node group demand by 24% compared to that determined by engineering knowledge. Based on the results, more pipe flow sensors should be installed to measure small flows and to further enhance the demand estimation accuracy.

  2. Deployment of check-in nodes in complex networks

    Science.gov (United States)

    Jiang, Zhong-Yuan; Ma, Jian-Feng

    2017-01-01

    In many real complex networks such as the city road networks and highway networks, vehicles often have to pass through some specially functioned nodes to receive check-in like services such as gas supplement at gas stations. Based on existing network structures, to guarantee every shortest path including at least a check-in node, the location selection of all check-in nodes is very essential and important to make vehicles to easily visit these check-in nodes, and it is still remains an open problem in complex network studies. In this work, we aim to find possible solutions for this problem. We first convert it into a set cover problem which is NP-complete and propose to employ the greedy algorithm to achieve an approximate result. Inspired by heuristic information of network structure, we discuss other four check-in node location deployment methods including high betweenness first (HBF), high degree first (HDF), random and low degree first (LDF). Finally, we compose extensive simulations in classical scale-free networks, random networks and real network models, and the results can well confirm the effectiveness of the greedy algorithm. This work has potential applications into many real networks.

  3. Identifying controlling nodes in neuronal networks in different scales.

    Science.gov (United States)

    Tang, Yang; Gao, Huijun; Zou, Wei; Kurths, Jürgen

    2012-01-01

    Recent studies have detected hubs in neuronal networks using degree, betweenness centrality, motif and synchronization and revealed the importance of hubs in their structural and functional roles. In addition, the analysis of complex networks in different scales are widely used in physics community. This can provide detailed insights into the intrinsic properties of networks. In this study, we focus on the identification of controlling regions in cortical networks of cats' brain in microscopic, mesoscopic and macroscopic scales, based on single-objective evolutionary computation methods. The problem is investigated by considering two measures of controllability separately. The impact of the number of driver nodes on controllability is revealed and the properties of controlling nodes are shown in a statistical way. Our results show that the statistical properties of the controlling nodes display a concave or convex shape with an increase of the allowed number of controlling nodes, revealing a transition in choosing driver nodes from the areas with a large degree to the areas with a low degree. Interestingly, the community Auditory in cats' brain, which has sparse connections with other communities, plays an important role in controlling the neuronal networks.

  4. Molecular portrait-based correlation between primary canine mammary tumor and its lymph node metastasis: possible prognostic-predictive models and/or stronghold for specific treatments?

    Directory of Open Access Journals (Sweden)

    Beha Germana

    2012-11-01

    Full Text Available Abstract Background This study aimed to evaluate the relationship between the molecular phenotype of the primary mammary tumor and its related lymph node metastasis in the dog to develop prognostic-predictive models and targeted therapeutic options. Results Twenty mammary tumor samples and their lymph node metastases were selected and stained by immunohistochemistry with anti-estrogen receptor (ER, -progesterone receptor (PR, -human epidermal growth factor receptor 2 (c-erbB-2, -cytokeratin 5/6 (CK 5/6, -cytokeratin 14 (CK14, -cytokeratin 19 (CK 19 and -protein 63 (p63 antibodies. Four phenotypes (luminal A, luminal B, c-erbB2 overexpressing and basal-like were diagnosed in primary tumors and five (luminal A, luminal B, c-erbB-2 overexpressing, basal-like and normal-like in the lymph node metastases. Phenotypic concordance was found in 13 of the 20 cases (65%, and seven cases (35% showed discordance with different lymph node phenotypic profile from the primary tumor. Conclusions The phenotype of the primary tumor assumes a predictive-therapeutic role only in concordant cases, meaning that both the primary tumor and its lymph node metastasis should be evaluated at the same time. A treatment plan based only on the primary tumor phenotype could lead to therapeutic failures if the phenotype of the lymph node metastasis differs from that of the primary tumor.

  5. Node 3 Relocation Environmental Control and Life Support System Modification Kit Verification and Updated Status

    Science.gov (United States)

    Williams, David E.; Spector Lawrence N.

    2010-01-01

    Node 1 (Unity) flew to International Space Station (ISS) on Flight 2A. Node 1 was the first module of the United States On-Orbit Segment (USOS) launched to ISS. The Node 1 ISS Environmental Control and Life Support (ECLS) design featured limited ECLS capability. The main purpose of Node 1 was to provide internal storage by providing four stowage rack locations within the module and to allow docking of multiple modules and a truss segment to it. The ECLS subsystems inside Node 1 were routed through the element prior to launch to allow for easy integration of the attached future elements, particularly the Habitation Module which was planned to be located at the nadir docking port of Node 1. After Node I was on-orbit, the Program decided not to launch the Habitation Module and instead, to replace it with Node 3 (Tranquility). In 2007, the Program became concerned with a potential Russian docking port approach issue for the Russian FGB nadir docking port after Node 3 is attached to Node 1. To solve this concern the Program decided to relocate Node 3 from Node I nadir to Node 1 port. To support the movement of Node 3 the Program decided to build a modification kit for Node 1, an on-orbit feedthrough leak test device, and new vestibule jumpers to support the ECLS part of the relocation. This paper provides a design overview of the modification kit for Node 1, a summary of the Node 1 ECLS re-verification to support the Node 3 relocation from Node 1 nadir to Node 1 port, and a status of the ECLS modification kit installation into Node 1.

  6. Detection of Sentinel Lymph Nodes in Patients with Papillary Thyroid Cancer

    Directory of Open Access Journals (Sweden)

    Hiroshi Takami

    2003-07-01

    Conclusions: Sentinel lymph node biopsy may allow discrimination between patients with true lymph-node-negative papillary thyroid carcinoma and those with non-palpable metastatic lymph nodes. It may also be helpful in diagnosing metastases and avoiding unnecessary lymph node dissection in thyroid cancer.

  7. Molecular and functional imaging for detection of lymph node metastases in prostate cancer

    NARCIS (Netherlands)

    Fortuin, A.S.; Rooij, M. de; Zamecnik, P.; Haberkorn, U.; Barentsz, J.

    2013-01-01

    Knowledge on lymph node metastases is crucial for the prognosis and treatment of prostate cancer patients. Conventional anatomic imaging often fails to differentiate benign from metastatic lymph nodes. Pelvic lymph node dissection is an invasive technique and underestimates the extent of lymph node

  8. Advances in Lymph Node Metastasis and the Modes of Lymph Node 
Dissection in Early Stage Non-small Cell Lung Caner

    Directory of Open Access Journals (Sweden)

    Ningning DING

    2016-06-01

    Full Text Available Lung cancer ranks the first position in morbidity and mortality among all malignances in China. Non-small cell lung cancer (NSCLC accounts for nearly 80% of all lung malignancies. Surgical resection is still the current major treatment method for early stage NSCLC. Lymph node stages together with the extent of lymph node dissection directly affect the prognosis. Anatomical lobectomy with systematic mediastinal lymph node dissection have been the standard surgical treatment for NSCLC. However, it is controversial in the extent of lymph node dissection for early stage NSCLC. Accurate nodes stage and the extent of mediatinal nodes dissection affect the peri-operative complications and the prognosis of NSCLC greatly. In the past decade, more and more surgeons demostrated that lobe-specific or selective mediastinal lymph node dissection is suitable for clinical stage I NSCLC, especially the stage Ia lesions, and may become the standard lymph node dissection mode in the future.

  9. [Advances in Lymph Node Metastasis and the Modes of Lymph Node 
Dissection in Early Stage Non-small Cell Lung Caner].

    Science.gov (United States)

    Ding, Ningning; Mao, Yousheng

    2016-06-20

    Lung cancer ranks the first position in morbidity and mortality among all malignances in China. Non-small cell lung cancer (NSCLC) accounts for nearly 80% of all lung malignancies. Surgical resection is still the current major treatment method for early stage NSCLC. Lymph node stages together with the extent of lymph node dissection directly affect the prognosis. Anatomical lobectomy with systematic mediastinal lymph node dissection have been the standard surgical treatment for NSCLC. However, it is controversial in the extent of lymph node dissection for early stage NSCLC. Accurate nodes stage and the extent of mediatinal nodes dissection affect the peri-operative complications and the prognosis of NSCLC greatly. In the past decade, more and more surgeons demostrated that lobe-specific or selective mediastinal lymph node dissection is suitable for clinical stage I NSCLC, especially the stage Ia lesions, and may become the standard lymph node dissection mode in the future.

  10. Methylene blue-assisted lymph node dissection technique is not associated with an increased detection of lymph node metastases in colorectal cancer.

    Science.gov (United States)

    Märkl, Bruno; Schaller, Tina; Krammer, Ines; Cacchi, Claudio; Arnholdt, Hans M; Schenkirsch, Gerhard; Kretsinger, Hallie; Anthuber, Matthias; Spatz, Hanno

    2013-09-01

    Lymph node staging is of paramount importance for prognosis estimation and therapy stratification in colorectal cancer. A high number of harvested lymph nodes is associated with an improved outcome. Methylene blue-assisted lymph node dissection effectively improves the lymph node harvest and ensures sufficient staging. Now, the effect on node positivity rate and stage-related outcome was investigated. The study cohort with advanced lymph node dissection consisted of 669 colorectal cancer cases of all stages, which were collected between 2007 and 2012. A historical collection of 663 cases investigated with conventional techniques between 2002 and 2004 served as control. Lymph node harvest was dramatically improved in the study group with mean lymph node numbers of 34 ± 17 vs 13 ± 5 (Pcancer and is therefore extremely helpful. The hypothesis that it also provides a higher sensitivity in detecting metastases, however, could be not proved.

  11. Coordinated node scheduling for energy-conserving in large wireless sensor networks

    Institute of Scientific and Technical Information of China (English)

    SHI Gao-tao; LIAO Ming-hong; XU Wen-xu

    2008-01-01

    Aiming at developing a node scheduling protocol for sensor networks with fewer active nodes, we pro-pose a coordinated node scheduling protocol based on the presentation of a solution and its optimization to deter-mine whether a node is redundant. The proposed protocol can reduce the number of working nodes by turning off as many redundant nodes as possible without degrading the coverage and connectivity. The simulation result shows that our protocol outperforms the peer with respect to the working node number and dynamic coverage percentage.

  12. Malignant Adenomyoepithelioma of the Breast with Lymph Node Metastasis: A Detailed Immunohistochemical Study

    Directory of Open Access Journals (Sweden)

    Ahlam A. Awamleh

    2012-01-01

    Full Text Available Malignant adenomyoepithelioma of the breast is a rare tumour with around 30 cases reported in the literature. Metastases associated with these tumours are usually haematogenous. Axillary lymph node metastases are thought to be unusual, and it has been recently suggested that axillary node dissection is not indicated unless clinically palpable. We here present a case of a 63-year-old woman, who developed a malignant adenomyoepithelioma with axillary lymph node metastasis, that included epithelial and myoepithelial elements, in spite of the absence of clinically enlarged nodes. We suggest that histological examination of axillary sentinel node(s or node sampling may be worthwhile in this condition.

  13. Twist modulates lymphangiogenesis and correlates with lymph node metastasis in supraglottic carcinoma

    Institute of Scientific and Technical Information of China (English)

    LU Su-mei; YU Liang; TIAN Jia-jun; MA Ju-ke; LI Jian-feng; XU Wei; WANG Hai-bo

    2011-01-01

    Background Twist is a highly conserved epithelial-mesenchymal transcription factor that has been reported to be a key factor in tumor malignancy, including lymph node metastasis. It represents the major step of dissemination and serves as a chief prognostic indicator of disease progression. However, the mechanism by which Twist regulates lymph node metastasis remains incompletely understood. Studies on the mechanism of metastasis are thus required for determining appropriate therapeutic strategies.Methods Immunohistochemistry for lymphatic vessel endothelial receptor 1 (LYVE-1), Ki-67, Twist, vascular endothelial growth factor C (VEGF-C), and vascular endothelial growth factor receptor 3 (VEGFR-3) was performed to detect lymphatic vessel density (LVD), cell proliferation levels and the expressions of Twist, VEGF-C, and VEGFR-3 were determined from 66 primary supraglottic carcinoma tissue samples from 36 patients with lymph node metastasis (pathological N+, pN+) and 30 patients without metastasis (pathological NO, pNO). Western blotting analysis of the proteins in pN+ and pNO primary tumors was used to characterize the expressions of Twist, VEGF-C, and VEGFR-3further.Results The LVD was 22.4±10.3 in pN+ patients and 6.8±4.1 in pNO ones. For Ki-67, the number of proliferous cells in pN+ patients was greater than that in pNO ones. Both, however, were associated with their clinical nodal stages. In pN+patients, Twist, VEGF-C, and VEGFR-3 expressions were 86.11% (31/36), 80.56% (29/36), and 58.33% (21/36),respectively. These values were higher than those found for pNO patients (i.e., 13/30, 11/30, and 7/30, respectively) (P <0.05). Among the samples with Twist expression, 88.64% were VEGF-C-positive and 59.09% were VEGFR-3-positive.The pNO counterparts were 4.55% and 9.09%, respectively (P<0.05). The expressions of Twist, VEGF-C, and VEGFR-3in pN+ patients obtained through Western blotting analysis were significantly higher than those in pNO patients, and the

  14. Does extended lymph node dissection affect the lymph node density and survival after radical cystectomy?

    Directory of Open Access Journals (Sweden)

    A Dharaskar

    2011-01-01

    Full Text Available Background : Diagnostic and therapeutic importance of pelvic lymph node (LN dissection (PLND in radical cystectomy (RC has gained recent attention. A method of pathological analysis of LN affects total number of LN removed, number of LN involved, and LN density. Objective : To compare extended lymphadenectomy to standard lymphadenectomy in terms of LN yield, density, and effect on survival. Materials and Methods : From Jan 2004 - July 2009, 78 patients underwent RC whose complete histopathological report was available for analysis. All were transitional cell carcinoma. From July 2007 onward extended LN dissection was started and LNs were sent in six packets. Twenty-eight patients of standard PLND kept in group I. Group II had 23 patients of standard PLND (LN sent in four packets, and group III had 23 patients of extended PLND (LN sent in six packets. SPSS 15 software used for statistical calculation. Results : Distribution of T-stage among three groups is not statistically significant. Median number of LN harvested were 5 (range, 1-25 in group I, 9 (range, 3-28 in group II, and 16 (range, 1-25 in group III. Although this is significant, we did not find significant difference in number of positive LN harvested. We did not find any patient with skip metastasis to common iliac LN in group 3. Conclusions : Separate package LN evaluation significantly increased the total number of LN harvested without increasing the number of positive LN and survival.

  15. EGFR EXPRESSION IN RECTAL CANCER, RELATION TO THE FREAQUENCY OF LYMPH NODE METASTASIS

    Directory of Open Access Journals (Sweden)

    I. V. Stepanov

    2017-01-01

    Full Text Available The processes of vital activity of cancer cells mainly depend on the production of growth factors and their receptors. The epidermal growth factor receptor (EGFR is a member of the ErbB family of receptor tyrosine kinases. Normally, binding of EGFR ligands and transforming growth factor alpha (TGFα induces receptor activation, which triggers erk and PI3K signaling pathways that control cell proliferation, migration, invasion and many other processes. A number of studies have shown that a high percentage of EGFR expression is observed in 25–82 % of cases with rectal cancer. Thus, the expression and mutation of the EGFR gene is associated with various variants of tumor progression and an unfavorable prognosis for malignant tumors of various localizations. The purpose of the study was to investigate the EGFR expression in cancer tissue and evaluate the relationship between EGFR expression and parameters of lymphogenous metastasis in patients with rectal cancer.  Material And Methods. Surgical specimens of 149 patients with stage T1–4N0–2M0, rectal adenocarcinoma, who were treated at the Cancer Research Institute of Tomsk National Research Medical Center, were studied using histological and immunohistochemical analyses. Positive EGFR expression was found in 88 (59.1 % patients. Diagnosis was made according to WHO classification (2010. Results. When studying the EGFR expression in tumor cells on different depth of invasion, it was found that the positive expression of this marker was observed in cases with and without lymph node metastases. The analysis of the EGFR expression in various structures of the parenchymatous component of the tumor located in different layers of the intestinal wall showed that in the solid structures of the mucosa, the positive expression of EGFR was detected more often in cases without lymph node metastases. In patients with lymph node metastases, the percentage of the EGFR expression was lower.  A similar pattern

  16. Singular and Regular Implementations of the Hybrid Boundary Node Method

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The hybrid boundary node method (HdBNM) combines a modified function with the moving least squares approximation to form a boundary-only truly meshless method. This paper describes two implementations of the HdBNM, the singular hybrid boundary node method (ShBNM) and the regular hybrid boundary node method (RhBNM). The ShBNM and RhBNM were compared with each other, and the parameters that influence their performance were studied in detail. The convergence rates and their applicability to thin structures were also investigated. The ShBNM and RhBNM are found to be very easy to implement and to efficiently obtain numerical solutions to computational mechanics problems.

  17. Immunolymphoscintigraphy for Metastatic Sentinel Nodes: Test of a Model

    Directory of Open Access Journals (Sweden)

    A. H. Chakera

    2011-01-01

    Full Text Available Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1, in immune-deficient (nude mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2 transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.

  18. HADOOP MAPREDUCE PERFORMANCE ENHANCEMENT USING IN-NODE COMBINERS

    Directory of Open Access Journals (Sweden)

    Woo-Hyun Lee

    2015-10-01

    Full Text Available While advanced analysis of large dataset is in high demand, data sizes have surpassed capabilities of conventional software and hardware. Hadoop framework distributes large datasets over multiple commodity servers and performs parallel computations. We discuss the I/O bottlenecks of Hadoop framework and propose methods for enhancing I/O performance. A proven approach is to cache data to maximize memory-locality of all map tasks. We introduce an approach to optimize I/O, the in-node combining design which extends the traditional combiner to a node level. The in-node combiner reduces the total number of intermediate results and curtail network traffic between mappers and reducers.

  19. Effectiveness of AODV Protocol under Hidden Node Environment

    Science.gov (United States)

    Garg, Ruchi; Sharma, Himanshu; Kumar, Sumit

    IEEE 802.11 is a standard for mobile ad hoc networks (MANET), implemented with various different protocols. Ad Hoc on Demand Distance Vector Routing (AODV) is one of the several protocols of IEEE 802.11, intended to provide various Quality of Service (QOS) parameters under acceptable range. To avoid the collision and interference the MAC protocol has only two solutions, one, to sense the physical carrier and second, to use the RTS/CTS handshake mechanism. But with the help of these methods AODV is not free from the problem of hidden nodes like other several protocols. Under the hidden node environment, performance of AODV depends upon various factors. The position of receiver and sender among the other nodes is very crucial and it affects the performance. Under the various situations the AODV is simulated with the help of NS2 and the outcomes are discussed.

  20. Fixed-Node Diffusion Monte Carlo of Lithium Systems

    CERN Document Server

    Rasch, Kevin

    2015-01-01

    We study lithium systems over a range of number of atoms, e.g., atomic anion, dimer, metallic cluster, and body-centered cubic crystal by the diffusion Monte Carlo method. The calculations include both core and valence electrons in order to avoid any possible impact by pseudo potentials. The focus of the study is the fixed-node errors, and for that purpose we test several orbital sets in order to provide the most accurate nodal hyper surfaces. We compare our results to other high accuracy calculations wherever available and to experimental results so as to quantify the the fixed-node errors. The results for these Li systems show that fixed-node quantum Monte Carlo achieves remarkably high accuracy total energies and recovers 97-99 % of the correlation energy.

  1. Node of Ranvier Disruption as a Cause of Neurological Diseases

    Directory of Open Access Journals (Sweden)

    Keiichiro Susuki

    2013-07-01

    Full Text Available Dysfunction and/or disruption of nodes of Ranvier are now recognized as key contributors to the pathophysiology of various neurological diseases. One reason is that the excitable nodal axolemma contains a high density of Nav (voltage-gated Na+ channels that are required for the rapid and efficient saltatory conduction of action potentials. Nodal physiology is disturbed by altered function, localization, and expression of voltage-gated ion channels clustered at nodes and juxtaparanodes, and by disrupted axon–glial interactions at paranodes. This paper reviews recent discoveries in molecular/cellular neuroscience, genetics, immunology, and neurology that highlight the critical roles of nodes of Ranvier in health and disease.

  2. Learning modular structures from network data and node variables

    CERN Document Server

    Azizi, Elham; Airoldi, Edoardo M

    2014-01-01

    A standard technique for understanding underlying dependency structures among a set of variables posits a shared conditional probability distribution for the variables measured on individuals within a group. This approach is often referred to as module networks, where individuals are represented by nodes in a network, groups are termed modules, and the focus is on estimating the network structure among modules. However, estimation solely from node-specific variables can lead to spurious dependencies, and unverifiable structural assumptions are often used for regularization. Here, we propose an extended model that leverages direct observations about the network in addition to node-specific variables. By integrating complementary data types, we avoid the need for structural assumptions. We illustrate theoretical and practical significance of the model and develop a reversible-jump MCMC learning procedure for learning modules and model parameters. We demonstrate the method accuracy in predicting modular structur...

  3. Optimal Node Placement in Underwater Wireless Sensor Networks

    KAUST Repository

    Felamban, M.

    2013-03-25

    Wireless Sensor Networks (WSN) are expected to play a vital role in the exploration and monitoring of underwater areas which are not easily reachable by humans. However, underwater communication via acoustic waves is subject to several performance limitations that are very different from those used for terresstrial networks. In this paper, we investigate node placement for building an initial underwater WSN infrastructure. We formulate this problem as a nonlinear mathematical program with the objective of minimizing the total transmission loss under a given number of sensor nodes and targeted coverage volume. The obtained solution is the location of each node represented via a truncated octahedron to fill out the 3D space. Experiments are conducted to verify the proposed formulation, which is solved using Matlab optimization tool. Simulation is also conducted using an ns-3 simulator, and the simulation results are consistent with the obtained results from mathematical model with less than 10% error.

  4. Topological node-line semimetal in compressed black phosphorus

    Science.gov (United States)

    Zhao, Jianzhou; Yu, Rui; Weng, Hongming; Fang, Zhong

    2016-11-01

    Based on first-principles calculations and tight-binding model analysis, we propose that black phosphorus (BP) can host a three-dimensional topological node-line semimetal state under pressure when spin-orbit coupling (SOC) is ignored. A closed topological node line exists in the first Brillouin zone (BZ) near the Fermi energy, which is protected by the coexistence of time-reversal and spatial inversion symmetry with band inversion driven by pressure. Drumheadlike surface states have been obtained on the beard (100) surface. Due to the weak intrinsic SOC of a phosphorus atom, a band gap less than 10 meV is opened along the node line in the presence of SOC, and the surface states are almost unaffected by SOC.

  5. 9nm node wafer defect inspection using visible light

    Science.gov (United States)

    Zhou, Renjie; Edwards, Chris; Popescu, Gabriel; Goddard, Lynford L.

    2014-04-01

    Over the past 2 years, we have developed a common optical-path, 532 nm laser epi-illumination diffraction phase microscope (epi-DPM) and successfully applied it to detect different types of defects down to 20 by 100 nm in a 22nm node intentional defect array (IDA) wafer. An image post-processing method called 2DISC, using image frame 2nd order differential, image stitching, and convolution, was used to significantly improve sensitivity of the measured images. To address 9nm node IDA wafer inspection, we updated our system with a highly stable 405 nm diode laser. By using the 2DISC method, we detected parallel bridge defects in the 9nm node wafer. To further enhance detectability, we are exploring 3D wafer scanning, white-light illumination, and dark-field inspection.

  6. DETECTION OF SENTINEL LYMPH NODE IN EARLY CERVICAL CANCER

    Institute of Scientific and Technical Information of China (English)

    刘琳; 李斌; 章文华

    2004-01-01

    Objective: To assess the value of sentinel lymph node (SLN) localization by lymphoscintigraphy and gamma probe detection in early cervical cancer. Methods: A total of 27 patients with operable invasive early cervical cancer and clinically proved negative pelvic lymph nodes were included in this study. The 99Tcm-dextran of 74 MBq (2 mCi) was injected around the cervix at 2( and 10(. Lymphoscintigraphy and gamma probe detection were used to find the SLN. Results: The SLN was identified in 27 patients. The sensitivity and specificity of the SLN detection to predict the metastasis of the pelvic lymph node were 100% and 100% respectively. Conclusion: Identification of the SLN using radionuclide is feasible and possible in women with early cervical cancer.

  7. XPath Node Selection over Grammar-Compressed Trees

    Directory of Open Access Journals (Sweden)

    Sebastian Maneth

    2013-11-01

    Full Text Available XML document markup is highly repetitive and therefore well compressible using grammar-based compression. Downward, navigational XPath can be executed over grammar-compressed trees in PTIME: the query is translated into an automaton which is executed in one pass over the grammar. This result is well-known and has been mentioned before. Here we present precise bounds on the time complexity of this problem, in terms of big-O notation. For a given grammar and XPath query, we consider three different tasks: (1 to count the number of nodes selected by the query, (2 to materialize the pre-order numbers of the selected nodes, and (3 to serialize the subtrees at the selected nodes.

  8. The paranodal cytoskeleton clusters Na(+) channels at nodes of Ranvier.

    Science.gov (United States)

    Amor, Veronique; Zhang, Chuansheng; Vainshtein, Anna; Zhang, Ao; Zollinger, Daniel R; Eshed-Eisenbach, Yael; Brophy, Peter J; Rasband, Matthew N; Peles, Elior

    2017-01-30

    A high density of Na(+) channels at nodes of Ranvier is necessary for rapid and efficient action potential propagation in myelinated axons. Na+ channel clustering is thought to depend on two axonal cell adhesion molecules that mediate interactions between the axon and myelinating glia at the nodal gap (i.e., NF186) and the paranodal junction (i.e., Caspr). Here we show that while Na(+) channels cluster at nodes in the absence of NF186, they fail to do so in double conditional knockout mice lacking both NF186 and the paranodal cell adhesion molecule Caspr, demonstrating that a paranodal junction-dependent mechanism can cluster Na(+) channels at nodes. Furthermore, we show that paranode-dependent clustering of nodal Na(+) channels requires axonal βII spectrin which is concentrated at paranodes. Our results reveal that the paranodal junction-dependent mechanism of Na(+)channel clustering is mediated by the spectrin-based paranodal axonal cytoskeleton.

  9. Lymph node hemangioma in one-humped camel

    Directory of Open Access Journals (Sweden)

    M.A. Aljameel

    2015-12-01

    Full Text Available Hemangioma is a benign tumor of blood and lymphatic vessels. It is common in skin, mucosa and soft tissues, and its occurrence in lymph nodes is extremely rare. A 10 year-old she-camel was slaughtered at Nyala slaughterhouse, South Darfur State, Sudan. Grossly, the carcass was emaciated. The left ventral superficial cervical lymph node was enlarged, hard on palpation and protruded outside the body. Its cut surface was dark red in color and measured (18 cm in diameter. Histopathologically, the sections revealed vascular masses were composed of non-encapsulated clusters of small and medium sized with thick and thin-walled, filled with blood, separated by courageous stroma and surrounded by closely packed proliferating capillaries. To the best of our knowledge, this is the first record of the left ventral superficial cervical lymph node hemangioma in a camel in the Sudan.

  10. Direct Visual Editing of Node Attributes in Graphs

    Directory of Open Access Journals (Sweden)

    Christian Eichner

    2016-10-01

    Full Text Available There are many expressive visualization techniques for analyzing graphs. Yet, there is only little research on how existing visual representations can be employed to support data editing. An increasingly relevant task when working with graphs is the editing of node attributes. We propose an integrated visualize-and-edit approach to editing attribute values via direct interaction with the visual representation. The visualize part is based on node-link diagrams paired with attribute-dependent layouts. The edit part is as easy as moving nodes via drag-and-drop gestures. We present dedicated interaction techniques for editing quantitative as well as qualitative attribute data values. The benefit of our novel integrated approach is that one can directly edit the data while the visualization constantly provides feedback on the implications of the data modifications. Preliminary user feedback indicates that our integrated approach can be a useful complement to standard non-visual editing via external tools.

  11. Symmetry-Enforced Line Nodes in Unconventional Superconductors

    Science.gov (United States)

    Micklitz, T.; Norman, M. R.

    2017-05-01

    We classify line nodes in superconductors with strong spin-orbit interactions and time-reversal symmetry, where the latter may include nonprimitive translations in the magnetic Brillouin zone to account for coexistence with antiferromagnetic order. We find four possible combinations of irreducible representations of the order parameter on high-symmetry planes, two of which allow for line nodes in pseudospin-triplet pairs and two that exclude conventional fully gapped pseudospin-singlet pairs. We show that the former can only be realized in the presence of band-sticking degeneracies, and we verify their topological stability using arguments based on Clifford algebra extensions. Our classification exhausts all possible symmetry protected line nodes in the presence of spin-orbit coupling and a (generalized) time-reversal symmetry. Implications for existing nonsymmorphic and antiferromagnetic superconductors are discussed.

  12. Analysis of distribution uniformity of nodes in wireless sensor networks

    Institute of Scientific and Technical Information of China (English)

    Zhang Zhenjiang

    2007-01-01

    Wireless sensor networks have several special characteristics which make against the network coverage, such as shortage of energy, difficulty with energy supply and so on. In order to prolong the lifetime of wireless sensor networks, it is necessary to balance the whole network load. As the energy consumption is related to the situation of nodes, the distribution uniformity must be considered. In this paper, a new model is proposed to evaluate the nodes distribution uniformity by considering some parameters which include compression discrepancy, sparseness discrepancy, self discrepancy, maximum cavity radius and minimum cavity radius. The simulation results show that the presented model could be helpful for measuring the distribution uniformity of nodes scattered randomly in wireless sensor networks.

  13. A New Node Deployment and Location Dispatch Algorithm for Underwater Sensor Networks

    Directory of Open Access Journals (Sweden)

    Peng Jiang

    2016-01-01

    Full Text Available Considering that deployment strategies for underwater sensor networks should contribute to fully connecting the networks, a Guaranteed Full Connectivity Node Deployment (GFCND algorithm is proposed in this study. The GFCND algorithm attempts to deploy the coverage nodes according to the greedy iterative strategy, after which the connectivity nodes are used to improve network connectivity and fully connect the whole network. Furthermore, a Location Dispatch Based on Command Nodes (LDBCN algorithm is proposed, which accomplishes the location adjustment of the common nodes with the help of the SINK node and the command nodes. The command nodes then dispatch the common nodes. Simulation results show that the GFCND algorithm achieves a comparatively large coverage percentage and a fully connected network; furthermore, the LDBCN algorithm helps the common nodes preserve more total energy when they reach their destination locations.

  14. Procedure guidelines for sentinel lymph node diagnosis; Verfahrensanweisung fuer die nuklearmedizinische Waechter-Lymphknoten-Diagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Vogt, H. [Klinikum Augsburg (Germany). Klinik fuer Nuklearmedizin; Schmidt, Matthias [Universitaeten zu Koeln (Germany). Klinik fuer Nuklearmedizin; Bares, R. [Klinik fuer Nuklearmedizin, Tuebingen (DE)] (and others)

    2010-07-01

    The authors present a procedure guideline for scintigraphic detection of sentinel lymph nodes in malignant melanoma and other skin tumours, in breast cancer, in head and neck cancer, and in prostate and penile carcinoma. Important goals of sentinel lymph node scintigraphy comprise reduction of the extent of surgery, lower postoperative morbidity and optimization of histopathological examination focussing on relevant lymph nodes. Sentinel lymph node scintigraphy itself does not diagnose tumorous lymph node involvement and is not indicated when lymph node metastases have been definitely diagnosed before sentinel lymph node scintigraphy. Procedures are compiled with the aim to reliably localise sentinel lymph nodes with a high detection rate typically in early tumour stages. Radiation exposure is low so that pregnancy is not a contraindication for sentinel lymph node scintigraphy. Even with high volumes of scintigraphic sentinel lymph node procedures surgeons, theatre staff and pathologists receive a radiation exposure <1 mSv/year so that they do not require occupational radiation surveillance. (orig.)

  15. Axillary Irradiation as an Imperative Alternative to Axillary Dissection in Clinically Lymph Node-Negative but Sentinel Node-Positive Breast Cancer Patients?

    OpenAIRE

    Nitsche, Mirko; Hermann, Robert

    2011-01-01

    At the moment, positive sentinel lymph node dissection (SLND) of the axilla is followed by axillary lymph node dissection (ALND) as standard of care. Recent data proves that omitting ALND after positive SLND in clinically lymph node-negative early stage breast cancer patients is feasible with low recurrence rates. The well known effect of radiotherapy to destroy occult tumor cells highly contributes to these results as a large extent of level I and II lymph nodes are unavoidably included in s...

  16. Ultrasonographic Evaluation of Cervical Lymph Nodes in Thyroid Cancer.

    Science.gov (United States)

    Machado, Maria Regina Marrocos; Tavares, Marcos Roberto; Buchpiguel, Carlos Alberto; Chammas, Maria Cristina

    2017-02-01

    Objective To determine what ultrasonographic features can identify metastatic cervical lymph nodes, both preoperatively and in recurrences after complete thyroidectomy. Study Design Prospective. Setting Outpatient clinic, Department of Head and Neck Surgery, School of Medicine, University of São Paulo, Brazil. Subjects and Methods A total of 1976 lymph nodes were evaluated in 118 patients submitted to total thyroidectomy with or without cervical lymph node dissection. All the patients were examined by cervical ultrasonography, preoperatively and/or postoperatively. The following factors were assessed: number, size, shape, margins, presence of fatty hilum, cortex, echotexture, echogenicity, presence of microcalcification, presence of necrosis, and type of vascularity. The specificity, sensitivity, positive predictive value, and negative predictive value of each variable were calculated. Univariate and multivariate logistic regression analyses were conducted. A receiver operator characteristic (ROC) curve was plotted to determine the best cutoff value for the number of variables to discriminate malignant lymph nodes. Results Significant differences were found between metastatic and benign lymph nodes with regard to all of the variables evaluated ( P < .05). Logistic regression analysis revealed that size and echogenicity were the best combination of altered variables (odds ratio, 40.080 and 7.288, respectively) in discriminating malignancy. The ROC curve analysis showed that 4 was the best cutoff value for the number of altered variables to discriminate malignant lymph nodes, with a combined specificity of 85.7%, sensitivity of 96.4%, and efficiency of 91.0%. Conclusion Greater diagnostic accuracy was achieved by associating the ultrasonographic variables assessed rather than by considering them individually.

  17. Robotic Salvage Lymph Node Dissection After Radical Prostatectomy.

    Science.gov (United States)

    Torricelli, Fabio C M; Cividanes, Arnaldo; Guglielmetti, Giuliano B; Coelho, Rafael F

    2015-01-01

    Radical prostatectomy is a first-line treatment for localized prostate cancer. However, in some cases, biochemical recurrence associated with imaging-detected nodal metastases may happen. Herein, we aim to present the surgical technique for salvage lymph node dissection after radical prostatectomy. A 70 year-old asymptomatic man presented with a prostate-specific antigen (PSA) of 7.45 ng/mL. Digital rectal examination was normal and trans-rectal prostate biopsy revealed a prostate adenocarcinoma Gleason 7 (3+4). Pre-operative computed tomography scan and bone scintigraphy showed no metastatic disease. In other service, the patient underwent a robotic-assisted radical prostatectomy plus obturador lymphadenectomy. Pathologic examination showed a pT3aN0 tumor. After 6 months of follow-up, serum PSA was 1.45 ng/mL. Further investigation with 11C--Choline PET/CT revealed only a 2-cm lymph node close to the left internal iliac artery. The patient was counseled for salvage lymph node dissection. Salvage lymph node dissection was uneventfully performed. Operative time was 1.5 hour, blood loss was minimal, and there were no intra- or postoperative complications. The patient was discharged from hospital in the 1st postoperative day. After 12 months of follow-up, his PSA was undetectable with no other adjuvant therapy. Robotic salvage pelvic lymph node dissection is an effective option for treatment of patients with biochemical recurrence after radical prostatectomy and only pelvic lymph node metastasis detected by C11-Choline PET/CT.

  18. Robotic Salvage Lymph Node Dissection After Radical Prostatectomy

    Directory of Open Access Journals (Sweden)

    Fabio C. M. Torricelli

    2015-08-01

    Full Text Available ABSTRACTIntroduction and objective:Radical prostatectomy is a first-line treatment for localized prostate cancer. However, in some cases, biochemical recurrence associated with imaging-detected nodal metastases may happen. Herein, we aim to present the surgical technique for salvage lymph node dissection after radical prostatectomy.Materials and Methods:A 70 year-old asymptomatic man presented with a prostate-specific antigen (PSA of 7.45ng/ mL. Digital rectal examination was normal and trans-rectal prostate biopsy revealed a prostate adenocarcinoma Gleason 7 (3+4. Pre-operative computed tomography scan and bone scintigraphy showed no metastatic disease. In other service, the patient underwent a robotic-assisted radical prostatectomy plus obturador lymphadenectomy. Pathologic examination showed a pT3aN0 tumor. After 6 months of follow-up, serum PSA was 1.45ng/mL. Further investigation with 11C–Choline PET/CT revealed only a 2-cm lymph node close to the left internal iliac artery. The patient was counseled for salvage lymph node dissection.Results:Salvage lymph node dissection was uneventfully performed. Operative time was 1.5 hour, blood loss was minimal, and there were no intra- or postoperative complications. The patient was discharged from hospital in the 1st postoperative day. After 12 months of follow-up, his PSA was undetectable with no other adjuvant therapy.Conclusion:Robotic salvage pelvic lymph node dissection is an effective option for treatment of patients with biochemical recurrence after radical prostatectomy and only pelvic lymph node metastasis detected by C11-Choline PET/CT.

  19. Corrected sinus node recovery time. Experimental physiologic and pathologic determinants.

    Science.gov (United States)

    Chadda, K D; Banka, V S; Bodenheimer, M M; Helfant, R H

    1975-05-01

    To determine the factors affecting reproducibility of sinus node recovery time, the effects of basic pacing rate, pacing duration, milliamperage, vagal and beta-adrenergic stimulation, and sinud node injury, as well as its instantaneous and daily reproducibility, were studied in 36 anesthetized dogs. Corrected sinus node recovery time (CSNRT) showed a mean variation of 9.8 plus or minus 0.4 msec at an atrial pacing rate of 200 beats/min and 29.8 plus or minus 8 msec at an atrial pacing rate of 140 beats/min (P smaller than 0.05). CSNRT increased progressively from 55.4 plus or minus 10 msec to 103.7 plus or minus 13 msec with increase in pacing rate from 140 beats/min to 200 beats/min. It was reproducible when atrial pacing was carried out for 1-5 min, although a wide variation (10-30 msec) was seen from 7-60 minutes (P smaller than 0.05). This measurement was reproducible on two consecutive days and was unaffected by changes in milliamperage. Vagal stimulation consistently prolonged the CSNRT while beta-adrenergic stimulation decreased it from 132.9 plus or minus 34.5 msec to 50.0 plus or minus 6.5 msec. Sinus node injury consistently prolonged CSNRT at all paced rates. In summary, CSNRT is reproducible only if the same pacing rate and duration are utilized. Since vagal stimulation and sinus node injury prolong this measurement while beta-adrenergic stimulation shortens it, an "abnormal" CSNRT should be assessed in terms of the possible influence of the autonomic nervous system as well as sinus node dysfunction per se.

  20. Investigation of Wireless Sensor Nodes with Energy Awareness for Multichannel Signal Measurement

    OpenAIRE

    Zhu, Zhenhuan

    2015-01-01

    Wireless Sensor Networks (WSNets), consisting of a lot of Wireless Sensor Nodes (WSNs), play an important role in structural health and machine condition monitoring. But the WSNs provided by the current market cannot meet the diversity of application requirements because they have limited functions, unreliable node performance, high node cost, high system redundancy, and short node lifespan.The aim of the research is to design the architecture of a WSN with low power consumption and node cos...

  1. Single benign metastasising leiomyoma of an inguinal lymph node.

    Science.gov (United States)

    Laban, Kamil G; Tobon-Morales, Roberto E; Hodge, Janice A L; Schreuder, Henk W R

    2016-08-10

    Benign metastasising leiomyoma (BML) is a rare benign disease associated with uterine leiomyoma and history of uterine surgery. It most frequently occurs in premenopausal woman, with a pulmonary localisation, and consisting of multiple nodules. We present an uncommon case of a 69-year-old woman with a single BML of an inguinal lymph node. CT scans of thorax and abdomen excluded other metastasis localisation. The patient was cured with surgical excision of the mass. Lymph node involvement has been reported incidentally in BML literature. Lymphangitic spread can be considered a possible mechanism of BML metastasis.

  2. Fuzzy nodes recognition based on spectral clustering in complex networks

    Science.gov (United States)

    Ma, Yang; Cheng, Guangquan; Liu, Zhong; Xie, Fuli

    2017-01-01

    In complex networks, information regarding the nodes is usually incomplete because of the effects of interference, noise, and other factors. This results in parts of the network being blurred and some information having an unknown source. In this paper, a spectral clustering algorithm is used to identify fuzzy nodes and solve network reconstruction problems. By changing the fuzzy degree of placeholders, we achieve various degrees of credibility and accuracy for the restored network. Our approach is verified by experiments using open source datasets and simulated data.

  3. Cavitatory mesenteric lymph node syndrome: A rare entity

    Directory of Open Access Journals (Sweden)

    Vibhuti

    2010-01-01

    Full Text Available Celiac disease is a gluten sensitive enteropathy that involves an abnormal immunological response to glutens in wheat, rye etc. It predominantly involves the small intestinal mucosa, though, extra luminal manifestations can also occur. One rare extraluminal manifestation is cavitatory mesenteric lymph node syndrome. It occurs in refractory celiac disease and is associated with poor prognosis due to various complications. The diagnosis is often made on imaging when cystic mesenteric lymph nodes with fat-fluid levels are seen and this can then be confirmed by histopathological examination. We recently had a typical case where we were able to make this diagnosis.

  4. The Nodal Location of Metastases in Melanoma Sentinel Lymph Nodes

    DEFF Research Database (Denmark)

    Riber-Hansen, Rikke; Nyengaard, Jens; Hamilton-Dutoit, Stephen

    2009-01-01

    BACKGROUND: The design of melanoma sentinel lymph node (SLN) histologic protocols is based on the premise that most metastases are found in the central parts of the nodes, but the evidence for this belief has never been thoroughly tested. METHODS: The nodal location of melanoma metastases in 149...... were 77%, 79%, and 78%, respectively. No difference in either the mean volume or the maximum diameter of the metastases located exclusively outside the central and the peripheral protocols was found (volume: 0.036 vs. 0.031 mm and diameter: 0.320 vs. 0.332 mm). CONCLUSIONS: In SLNs, melanoma metastases...

  5. PET-skanning ved malignt melanom og positiv sentinel node

    DEFF Research Database (Denmark)

    Horn, Janne; Sjøstrand, Helle; Lock-Andersen, Jørgen;

    2010-01-01

    To illuminate the value of using positron emission tomography (PET) scan as a clinical routine screening procedure for detecting subclinical metastases in melanoma patients with positive sentinel node biopsy, we carried out a retrospective study which included a total of 80 patients.......To illuminate the value of using positron emission tomography (PET) scan as a clinical routine screening procedure for detecting subclinical metastases in melanoma patients with positive sentinel node biopsy, we carried out a retrospective study which included a total of 80 patients....

  6. MR findings of large schmorl's nodes

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Wook; Lee, Seung Ik [Pundang CHA Hospital, Sungnam (Korea, Republic of)

    1998-10-01

    To demonstrate the MR findings of large Schmorl's nodes(>1cm). Six hundred patients underwent MRI and the results were retrospectively analysed. Eleven patients(1.83%) had 12 large Schmorl's nodes. We analyzed the size, contour, location, signal changes and enhancement of these, as well as marrow changes in adjacent vertebral bodies. Twelve large Schmorl's nodes were found in eleven of 600 patients(1.83%) with a mean age of 46.1 years and a female:male ratio of 4:7. Their mean size was 1.35cm(AP)x0.99cm(height)x1.23cm(transverse), and they were observed at various sites, namely lower(n=3D7) and upper end-plate locations(n=3D5). Central locations(n=3D8) on end-plates were most common. A semi-lunar appearance was noted in seven cases, and in most , a well-demarcated irregular margin was seen. All large Schmorl's nodes were enhanced;peripheral forms(n=3D8) were more common than diffuse(n=3D4). Adjacent discs showed no intranuclear enhancement but in seven cases there was flat-contoured enhancements in the annulus fibrosus. In disks with large Schmorl's nodes, degeneration was noted on T2WI regardless of the degree of diskal herniation. In nearly all cases, signal intensity on T1WI was low, but on T2WI, this was variable. Large Schmorl's nodes showed characteristic marrow change in adjacent vertebral bodies;the most common pattern was fatty and sclerotic(n=3D8). Especially on T1-weighted axial images, target appearances were visible in ten cases. MR findings of Schmorl's nodes will be very useful for differentiating nodes from other vertebral or diskal lesions, especially spondylitis combined with diskitis or vertebral body tumor.=20.

  7. Malakoplakia of the pancreas with diffuse lymph-node involvement.

    Science.gov (United States)

    Nuciforo, Paolo Giovanni; Moneghini, Laura; Braidotti, Paola; Castoldi, Laura; De Rai, Paolo; Bosari, Silvano

    2003-01-01

    We report a case of malakoplakia involving the pancreas in a 74-year-old man with associated regional lymphoadenopathy. Histological examination of both pancreas and lymph nodes revealed a diffuse histiocytic infiltrate containing numerous Michaelis-Gutmann bodies. Electron microscopy supported the diagnosis of malakoplakia and showed bacterial-like structures. Differential diagnosis includes myofibroblastic inflammatory tumor and histiocytic neoplasms. Lymph-node involvement during malakoplakia is extremely rare and it has never been documented microscopically. Lymphohematogenous spread of bacteria may be the cause of the nodal involvement, which, however, does not appear to influence the clinical course of the disease.

  8. Formation of technical requirements for flexible rotary machine nodes

    Science.gov (United States)

    Bulenkov, Y.; Mikhaylov, A.

    2016-11-01

    The method of parameters determining for the flexible rotary machines and lines and its individual components is described in this article. The method is based on the analysis of the fail safe performance probability. It allows determining the fail safe performance probability for tools, transportation and tool changing device nodes, elements of flexible rotary machine and is based on the analysis of flexible rotor line structure. The relationships between rational flexible rotary line structure and parameters of the individual nodes are shown on the flexible rotor line for the screws processing.

  9. Empowering smartphone users with sensor node for air quality measurement

    Science.gov (United States)

    Oletic, Dinko; Bilas, Vedran

    2013-06-01

    We present an architecture of a sensor node developed for use with smartphones for participatory sensing of air quality in urban environments. Our solution features inexpensive metal-oxide semiconductor gas sensors (MOX) for measurement of CO, O3, NO2 and VOC, along with sensors for ambient temperature and humidity. We focus on our design of sensor interface consisting of power-regulated heater temperature control, and the design of resistance sensing circuit. Accuracy of the sensor interface is characterized. Power consumption of the sensor node is analysed. Preliminary data obtained from the CO gas sensors in laboratory conditions and during the outdoor field-test is shown.

  10. Microfluidic ultrasonic particle separators with engineered node locations and geometries

    Energy Technology Data Exchange (ETDEWEB)

    Rose, Klint A.; Fisher, Karl A.; Wajda, Douglas A.; Mariella, Jr., Raymond P.; Bailey, Christopher; Dehlinger, Dietrich; Shusteff, Maxim; Jung, Byoungsok; Ness, Kevin D.

    2016-04-26

    An ultrasonic microfluidic system includes a separation channel for conveying a sample fluid containing small particles and large particles, flowing substantially parallel, adjacent to a recovery fluid, with which it is in contact. An acoustic transducer produces an ultrasound standing wave, that generates a pressure field having at least one node of minimum pressure amplitude. An acoustic extension structure is located proximate to said separation channel for positioning said acoustic node off center in said acoustic area and concentrating the large particles in said recovery fluid stream.

  11. Superconducting quantum node for entanglement and storage of microwave radiation.

    Science.gov (United States)

    Flurin, E; Roch, N; Pillet, J D; Mallet, F; Huard, B

    2015-03-06

    Superconducting circuits and microwave signals are good candidates to realize quantum networks, which are the backbone of quantum computers. We have realized a quantum node based on a 3D microwave superconducting cavity parametrically coupled to a transmission line by a Josephson ring modulator. We first demonstrate the time-controlled capture, storage, and retrieval of an optimally shaped propagating microwave field, with an efficiency as high as 80%. We then demonstrate a second essential ability, which is the time-controlled generation of an entangled state distributed between the node and a microwave channel.

  12. Superconducting Quantum Node for Entanglement and Storage of Microwave Radiation

    Science.gov (United States)

    Flurin, E.; Roch, N.; Pillet, J. D.; Mallet, F.; Huard, B.

    2015-03-01

    Superconducting circuits and microwave signals are good candidates to realize quantum networks, which are the backbone of quantum computers. We have realized a quantum node based on a 3D microwave superconducting cavity parametrically coupled to a transmission line by a Josephson ring modulator. We first demonstrate the time-controlled capture, storage, and retrieval of an optimally shaped propagating microwave field, with an efficiency as high as 80%. We then demonstrate a second essential ability, which is the time-controlled generation of an entangled state distributed between the node and a microwave channel.

  13. Metastasis in the subcarinal lymph node with unknown primary tumor

    DEFF Research Database (Denmark)

    Eckardt, J.; Olsen, K. E.; Petersen, H.

    2011-01-01

    -differentiated squamous cell carcinoma but no primary tumor was visible on PET-computed tomography. Because of his previous lymphoma the patient was scheduled for mediastinoscopy where the diagnosis was confirmed. Subsequent gastroscopy was normal and a right-sided thoracotomy showed no evidence of cancer elsewhere, only...... an inoperable metastasis in a subcarinal lymph node which infiltrated the trachea, esophagus and aorta. Such isolated squamous cell carcinoma in a subcarinal lymph node without a primary tumor despite invasive work-up has not been reported before....

  14. Mesh Router Nodes placement in Rural Wireless Mesh Networks

    OpenAIRE

    Ebongue, Jean Louis Fendji Kedieng; Thron, Christopher; Nlong, Jean Michel

    2015-01-01

    The problem of placement of mesh router nodes in Wireless Mesh Networks is known to be a NP hard problem. In this paper, the problem is addressed under a constraint of network model tied to rural regions where we usually observe low density and sparse population. We consider the area to cover as decomposed into a set of elementary areas which can be required or optional in terms of coverage and where a node can be placed or not. We propose an effective algorithm to ensure the coverage. This a...

  15. Two Novel Structures of Optical Packet Switching Nodes

    Institute of Scientific and Technical Information of China (English)

    YIN Hongxi; XU Anshi; WU Deming

    2001-01-01

    All-optical packet switching networkis currently one of the research hotspots of all-opticalcommunication networks and optical packet switchingnodes are the key technique of optical packet switch-ing network. In this paper, two novel structures ofoptical packet switching nodes are put forward, and the switching capacity of the node and the packet con-tention resolution are analyzed. These two switchingarchitectures can realize wavelength routing switchingfunction and broadcast-and-select switching functionrespectively. They are simple but efficient for realizingoptical packet switching network.

  16. Research on the WSN Node Localization Based on TOA

    Directory of Open Access Journals (Sweden)

    Qing-hui Wang

    2013-01-01

    Full Text Available Regarding the tracking of moving target in the large-scale fixed scene, a new routing algorithm of LAODV in the principle of TOA localization is proposed. Then, the participation field of the fixed node based on the node location information is properly controlled, while the routing request area is reduced through combination of AODV and LAR during transmission of the location information. Simulation results show that the proposed algorithm renders satisfactory performance in terms of average delay reduction from end to end, packet loss rate, and routing overhead. As a result, the delay and system overhead during localization could be minimized.

  17. 实时定量PCR检测VEGFs在宫颈癌的表达以及与淋巴结转移的关系%Expression of Vascular Endothelial Growth Factor in Cervical Cancer and Its Relationship with Lymph Node Metastasis

    Institute of Scientific and Technical Information of China (English)

    李亮; 陈滢; 汪晶; 王晶; 李少蓉

    2013-01-01

    目的 研究血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)A,C,D以及淋巴管内皮细胞标记物Prox-1在宫颈癌组织中的表达情况,分析其与宫颈癌临床分期和淋巴转移的关系,以及VEGF-C/VEGF-D/VEGFR-3信号途径之间的相互关系.方法 采用逆转录酶-聚合酶链反应(reverse transcri ptase-polymerase chain,RTPCR)及Real time RT-PCR法分析100例宫颈癌组织和20例正常宫颈组织中VEGF-A,C,D以及Prow1的表达情况.结果 VEGF-A,D和Prox-1的表达水平在淋巴转移组织和未发生淋巴转移的组织中有统计学差异,VEGF-C在癌症组织的表达低于正常组织,但随着临床分期的增加,呈一定的增高趋势.结论 VEGF-A,C,D在淋巴结转移过程中发挥了重要作用,可能从多方面影响宫颈癌的发生、发展和转移.

  18. Frozen section analysis of sentinel lymph nodes in patients with breast cancer does not impair the probability to detect lymph node metastases

    NARCIS (Netherlands)

    E.V.E. Madsen (Eva V. E.); J. van Dalen (Jan); P.J. van Gorp (Patrick); P.M.P. Van Oort (Poultje M. P.)

    2012-01-01

    textabstractIntra-operative frozen section analysis (FS analysis) of sentinel lymph nodes (SLNs) in patients with breast cancer can prevent a second operation for axillary lymph node dissection. In contrast, loss of tissue during FS analysis may impair the probability to detect lymph node metastases

  19. Information slows down hierarchy growth

    CERN Document Server

    Czaplicka, Agnieszka; Minano, Borja; Trias, Miquel; Holyst, Janusz A

    2013-01-01

    We consider models of a growing tree with the growth process driven by the rules of tournament selection, where a new node is attached to a contestant node at the best hierarchy level (closest to the tree root). The proposed evolution reflects limited information about the network topology that is available for new nodes. Two cases are considered: the constant tournament (CT) model where the number of tournament participants is constant throughout the tree evolution, and the proportional tournament (PT) model where it is grows proportionally to the actual tree size. The results of analytical calculations based on a rate equation fit well to numerical simulations for both models. In the CT model all hierarchy levels emerge in the tree but the birth time of the hierarchy level increases exponentially or faster with level number. The number of nodes at the first hierarchy level (just below the root) grows logarithmically in time, while the size of the last, "worst" hierarchy level oscillates quasi log-periodical...

  20. Growth Hormone

    Science.gov (United States)

    ... AACC products and services. Advertising & Sponsorship: Policy | Opportunities Growth Hormone Share this page: Was this page helpful? Also known as: GH; Human Growth Hormone; HGH; Somatotropin; Growth Hormone Stimulation Test; Growth ...