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Sample records for nonlinear parabolic pde

  1. Viscosity solutions of fully nonlinear functional parabolic PDE

    Directory of Open Access Journals (Sweden)

    Liu Wei-an

    2005-01-01

    Full Text Available By the technique of coupled solutions, the notion of viscosity solutions is extended to fully nonlinear retarded parabolic equations. Such equations involve many models arising from optimal control theory, economy and finance, biology, and so forth. The comparison principle is shown. Then the existence and uniqueness are established by the fixed point theory.

  2. Sampled-Data Fuzzy Control for Nonlinear Coupled Parabolic PDE-ODE Systems.

    Science.gov (United States)

    Wang, Zi-Peng; Wu, Huai-Ning; Li, Han-Xiong

    2017-09-01

    In this paper, a sampled-data fuzzy control problem is addressed for a class of nonlinear coupled systems, which are described by a parabolic partial differential equation (PDE) and an ordinary differential equation (ODE). Initially, the nonlinear coupled system is accurately represented by the Takagi-Sugeno (T-S) fuzzy coupled parabolic PDE-ODE model. Then, based on the T-S fuzzy model, a novel time-dependent Lyapunov functional is used to design a sampled-data fuzzy controller such that the closed-loop coupled system is exponentially stable, where the sampled-data fuzzy controller consists of the ODE state feedback and the PDE static output feedback under spatially averaged measurements. The stabilization condition is presented in terms of a set of linear matrix inequalities. Finally, simulation results on the control of a hypersonic rocket car are given to illustrate the effectiveness of the proposed design method.

  3. Distributed Proportional-spatial Derivative control of nonlinear parabolic systems via fuzzy PDE modeling approach.

    Science.gov (United States)

    Wang, Jun-Wei; Wu, Huai-Ning; Li, Han-Xiong

    2012-06-01

    In this paper, a distributed fuzzy control design based on Proportional-spatial Derivative (P-sD) is proposed for the exponential stabilization of a class of nonlinear spatially distributed systems described by parabolic partial differential equations (PDEs). Initially, a Takagi-Sugeno (T-S) fuzzy parabolic PDE model is proposed to accurately represent the nonlinear parabolic PDE system. Then, based on the T-S fuzzy PDE model, a novel distributed fuzzy P-sD state feedback controller is developed by combining the PDE theory and the Lyapunov technique, such that the closed-loop PDE system is exponentially stable with a given decay rate. The sufficient condition on the existence of an exponentially stabilizing fuzzy controller is given in terms of a set of spatial differential linear matrix inequalities (SDLMIs). A recursive algorithm based on the finite-difference approximation and the linear matrix inequality (LMI) techniques is also provided to solve these SDLMIs. Finally, the developed design methodology is successfully applied to the feedback control of the Fitz-Hugh-Nagumo equation.

  4. Optimal control of a class of nonlinear parabolic PDE systems arising in fusion plasma current profile dynamics

    Science.gov (United States)

    Ou, Yongsheng

    control) but also to modify the resistivity of the plasma (diffusivity control). Motivated by the current profile control problem in nuclear fusion reactors, we study in this thesis a particular class of nonlinear parabolic PDEs that admit interior, boundary and diffusivity actuation. We make in this way theoretical and practical contributions to control systems and nuclear fusion respectively. First, a simplified dynamic PDE model describing the evolution of the poloidal flux, and therefore the q profile, during the inductive phase of the discharge is introduced. Simulation results show qualitative agreement with experiments. Then, a multi-parameter, extremum-seeking, non-model-based, open-loop, optimal controller is designed, successfully tested in simulations, and implemented experimentally in the DIII-D tokamak, to match a desired q profile within a predefined time window during the flattop phase of the tokamak discharge. The controller is shown to be effective to deal with an optimal control problem defined for a nonlinear PDE system subject to many constraints in its actuators. Next, using the Proper Orthogonal Decomposition (POD) and Galerkin Projection techniques, we derive a finite dimensional ODE (Ordinary Differential Equation) dynamical system that preserves the dominant dynamics of the original infinite dimensional PDE system. This low dimensional model is used to design several closed-loop controllers, which have been tested successfully in simulations and are being implemented in the DIII-D tokamak: (i) we propose a convergent successive scheme based on the quasi-linear approximation to compute an optimal tracking control for the reduced order system; (ii) we formulate the problem as an abstract bilinear-quadratic regulator (BQR) problem. A receding horizon control (RHC) algorithm to solve the problem based on the infinite-dimensional system is proposed and stability of the algorithm for the solution of the BQR problem is studied; (iii) we present a robust

  5. Output Feedback-Based Boundary Control of Uncertain Coupled Semilinear Parabolic PDE Using Neurodynamic Programming.

    Science.gov (United States)

    Talaei, Behzad; Jagannathan, Sarangapani; Singler, John

    2017-03-06

    In this paper, neurodynamic programming-based output feedback boundary control of distributed parameter systems governed by uncertain coupled semilinear parabolic partial differential equations (PDEs) under Neumann or Dirichlet boundary control conditions is introduced. First, Hamilton-Jacobi-Bellman (HJB) equation is formulated in the original PDE domain and the optimal control policy is derived using the value functional as the solution of the HJB equation. Subsequently, a novel observer is developed to estimate the system states given the uncertain nonlinearity in PDE dynamics and measured outputs. Consequently, the suboptimal boundary control policy is obtained by forward-in-time estimation of the value functional using a neural network (NN)-based online approximator and estimated state vector obtained from the NN observer. Novel adaptive tuning laws in continuous time are proposed for learning the value functional online to satisfy the HJB equation along system trajectories while ensuring the closed-loop stability. Local uniformly ultimate boundedness of the closed-loop system is verified by using Lyapunov theory. The performance of the proposed controller is verified via simulation on an unstable coupled diffusion reaction process.

  6. Nonlinear Control of Delay and PDE Systems

    Science.gov (United States)

    Bekiaris-Liberis, Nikolaos

    In this dissertation we develop systematic procedures for the control and analysis of general nonlinear systems with delays and of nonlinear PDE systems. We design predictor feedback laws (i.e., feedback laws that use the future, rather than the current state of the system) for the compensation of delays (i.e., after the control signal reaches the system for the first time, the system behaves as there were no delay at all) that can be time-varying or state-dependent, on the input and on the state of nonlinear systems. We also provide designs of predic- tor feedback laws for linear systems with constant distributed delays and known or unknown plant parameters, and for linear systems with simultaneous known or unknown constant delays on the input and the state. Moreover, we intro- duce infinite-dimensional backstepping transformations for each particular prob-lem, which enables us to construct Lyapunov-Krasovskii functionals. With the available Lyapunov-Krasovskii functionals we study stability, as well as, robust- ness of our control laws to plant uncertainties. We deal with coupled PDE-ODE systems. We consider nonlinear systems with wave actuator dynamics, for which we design a predictor inspired feedback law. We study stability of the closed-loop system either by constructing Lyapunov functionals, or using arguments of explicit solutions. We also consider linear sys- tems with distributed actuator and sensor dynamics governed by diffusion or wave PDEs, for which we design stabilizing feedback laws. We study stability of the closed-loop systems using Lyapunov functionals that we construct with the intro- duction of infinite-dimensional transformations of forwarding type. Finally, we develop a control design methodology for coupled nonlinear first-order hyperbolic PDEs through an application to automotive catalysts.

  7. Tau approximation techniques for identification of coefficients in parabolic PDE

    Science.gov (United States)

    Banks, H. T.; Wade, J. G.

    1989-01-01

    A variant of the Tau method, called the weak Tau method, is developed on the basis of the weak form of the PDE for use in least-squares parameter estimation; also presented is a suitable abstract convergence framework. The emphasis is on the theoretical framework that allows treatment of the weak Tau method when it is applied to a wide class of inverse problems, including those for diffusion-advection equations, the Fokker-Planck model for population dynamics, and damped beam equations. Extensive numerical testing of the weak Tau method has demonstrated that it compares quite favorably with existing methods.

  8. Homogenization of a nonlinear degenerate parabolic equation

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The homogenization of one kind of nonlinear parabolic equation is studied. The weak convergence and corrector results are obtained by combining carefully the compactness method and two-scale convergence method in the homogenization theory.

  9. Nonlinear elliptic-parabolic problems

    CERN Document Server

    Kim, Inwon C

    2012-01-01

    We introduce a notion of viscosity solutions for a general class of elliptic-parabolic phase transition problems. These include the Richards equation, which is a classical model in filtration theory. Existence and uniqueness results are proved via the comparison principle. In particular, we show existence and stability properties of maximal and minimal viscosity solutions for a general class of initial data. These results are new even in the linear case, where we also show that viscosity solutions coincide with the regular weak solutions introduced in [Alt&Luckhaus 1983].

  10. Boundary Control of Linear Uncertain 1-D Parabolic PDE Using Approximate Dynamic Programming.

    Science.gov (United States)

    Talaei, Behzad; Jagannathan, Sarangapani; Singler, John

    2017-03-02

    This paper develops a near optimal boundary control method for distributed parameter systems governed by uncertain linear 1-D parabolic partial differential equations (PDE) by using approximate dynamic programming. A quadratic surface integral is proposed to express the optimal cost functional for the infinite-dimensional state space. Accordingly, the Hamilton-Jacobi-Bellman (HJB) equation is formulated in the infinite-dimensional domain without using any model reduction. Subsequently, a neural network identifier is developed to estimate the unknown spatially varying coefficient in PDE dynamics. Novel tuning law is proposed to guarantee the boundedness of identifier approximation error in the PDE domain. A radial basis network (RBN) is subsequently proposed to generate an approximate solution for the optimal surface kernel function online. The tuning law for near optimal RBN weights is created, such that the HJB equation error is minimized while the dynamics are identified and closed-loop system remains stable. Ultimate boundedness (UB) of the closed-loop system is verified by using the Lyapunov theory. The performance of the proposed controller is successfully confirmed by simulation on an unstable diffusion-reaction process.

  11. Controllability of nonlinear degenerate parabolic cascade systems

    Directory of Open Access Journals (Sweden)

    Mamadou Birba

    2016-08-01

    Full Text Available This article studies of null controllability property of nonlinear coupled one dimensional degenerate parabolic equations. These equations form a cascade system, that is, the solution of the first equation acts as a control in the second equation and the control function acts only directly on the first equation. We prove positive null controllability results when the control and a coupling set have nonempty intersection.

  12. Bifurcation and stability for a nonlinear parabolic partial differential equation

    Science.gov (United States)

    Chafee, N.

    1973-01-01

    Theorems are developed to support bifurcation and stability of nonlinear parabolic partial differential equations in the solution of the asymptotic behavior of functions with certain specified properties.

  13. Nonlinear observer design for a first order hyperbolic PDE: application to the estimation of the temperature in parabolic solar collectors**Research reported in this publication has been supported by the King Abdullah University of Science and Technology

    KAUST Repository

    Elmetennani, Shahrazed

    2016-08-09

    In this paper, the problem of estimating the distributed profile of the temperature along the tube of a concentrated distributed solar collector from boundary measurements is addressed. A nonlinear observer is proposed based on a nonlinear integral transformation. The objective is to force the estimation error to follow some stable transport dynamics. Convergence conditions are derived in order to determine the observer gain ensuring the stabilization of the estimation error in a finite time. Numerical simulations are given to show the effectiveness of the proposed algorithm under different working conditions. (C) 2016, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

  14. Almost Periodic Viscosity Solutions of Nonlinear Parabolic Equations

    Directory of Open Access Journals (Sweden)

    Zhang Shilin

    2009-01-01

    Full Text Available We generalize the comparison result 2007 on Hamilton-Jacobi equations to nonlinear parabolic equations, then by using Perron's method to study the existence and uniqueness of time almost periodic viscosity solutions of nonlinear parabolic equations under usual hypotheses.

  15. OSCILLATION OF NONLINEAR IMPULSIVE PARABOLIC DIFFERENTIAL EQUATIONS WITH SEVERAL DELAYS

    Institute of Scientific and Technical Information of China (English)

    CuiChenpei; ZouMin; LiuAnping; XiaoLi

    2005-01-01

    In this paper, oscillatory properties for solutions of certain nonlinear impulsive parabolic equations with several delays are investigated and a series of new sufficient conditions for oscillations of the equation are established.

  16. HYPERBOLIC-PARABOLIC CHEMOTAXIS SYSTEM WITH NONLINEAR PRODUCT TERMS

    Institute of Scientific and Technical Information of China (English)

    Chen Hua; Wu Shaohua

    2008-01-01

    We prove the local existence and uniqueness of week solution of the hyperbolic-parabolic Chemotaxis system with some nonlinear product terms. For one dimensional case, we prove also the global existence and uniqueness of the solution for the problem.

  17. IDENTIFICATION OF PARAMETERS IN PARABOLIC EQUATIONS WITH NONLINEARITY

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    In this paper, we consider the identification of parameters in parabolic equations with nonlinearity. Some approximation processes for the identification problem are given. Our results improve and generalize the previous results.

  18. Differentiability at lateral boundary for fully nonlinear parabolic equations

    Science.gov (United States)

    Ma, Feiyao; Moreira, Diego R.; Wang, Lihe

    2017-09-01

    For fully nonlinear uniformly parabolic equations, the first derivatives regularity of viscosity solutions at lateral boundary is studied under new Dini type conditions for the boundary, which is called Reifenberg Dini conditions and is weaker than usual Dini conditions.

  19. ACCELERATION METHODS OF NONLINEAR ITERATION FOR NONLINEAR PARABOLIC EQUATIONS

    Institute of Scientific and Technical Information of China (English)

    Guang-wei Yuan; Xu-deng Hang

    2006-01-01

    This paper discusses the accelerating iterative methods for solving the implicit scheme of nonlinear parabolic equations. Two new nonlinear iterative methods named by the implicit-explicit quasi-Newton (IEQN) method and the derivative free implicit-explicit quasi-Newton (DFIEQN) method are introduced, in which the resulting linear equations from the linearization can preserve the parabolic characteristics of the original partial differential equations. It is proved that the iterative sequence of the iteration method can converge to the solution of the implicit scheme quadratically. Moreover, compared with the Jacobian Free Newton-Krylov (JFNK) method, the DFIEQN method has some advantages, e.g., its implementation is easy, and it gives a linear algebraic system with an explicit coefficient matrix, so that the linear (inner) iteration is not restricted to the Krylov method. Computational results by the IEQN, DFIEQN, JFNK and Picard iteration meth-ods are presented in confirmation of the theory and comparison of the performance of these methods.

  20. Nonlinear Parabolic Equations with Singularities in Colombeau Vector Spaces

    Institute of Scientific and Technical Information of China (English)

    Mirjana STOJANOVI(C)

    2006-01-01

    We consider nonlinear parabolic equations with nonlinear non-Lipschitz's term and singular initial data like Dirac measure, its derivatives and powers. We prove existence-uniqueness theorems in Colombeau vector space gC1,w2,2([O,T),Rn),n ≤ 3. Due to high singularity in a case of parabolic equation with nonlinear conservative term we employ the regularized derivative for the conservative term, in order to obtain the global existence-uniqueness result in Colombeau vector space gC1,L2([O,T),Rn),n ≤ 3.

  1. Fabrication and characterization of non-linear parabolic microporous membranes.

    Science.gov (United States)

    Rajasekaran, Pradeep Ramiah; Sharifi, Payam; Wolff, Justin; Kohli, Punit

    2015-01-01

    Large scale fabrication of non-linear microporous membranes is of technological importance in many applications ranging from separation to microfluidics. However, their fabrication using traditional techniques is limited in scope. We report on fabrication and characterization of non-linear parabolic micropores (PMS) in polymer membranes by utilizing flow properties of fluids. The shape of the fabricated PMS corroborated well with simplified Navier-Stokes equation describing parabolic relationship of the form L - t(1/2). Here, L is a measure of the diameter of the fabricated micropores during flow time (t). The surface of PMS is smooth due to fluid surface tension at fluid-air interface. We demonstrate fabrication of PMS using curable polydimethylsiloxane (PDMS). The parabolic shape of micropores was a result of interplay between horizontal and vertical fluid movements due to capillary, viscoelastic, and gravitational forces. We also demonstrate fabrication of asymmetric "off-centered PMS" and an array of PMS membranes using this simple fabrication technique. PMS containing membranes with nanoscale dimensions are also possible by controlling the experimental conditions. The present method provides a simple, easy to adopt, and energy efficient way for fabricating non-linear parabolic shape pores at microscale. The prepared parabolic membranes may find applications in many areas including separation, parabolic optics, micro-nozzles / -valves / -pumps, and microfluidic and microelectronic delivery systems.

  2. Random perturbations of nonlinear parabolic systems

    CERN Document Server

    Beck, Lisa

    2011-01-01

    Several aspects of regularity theory for parabolic systems are investigated under the effect of random perturbations. The deterministic theory, when strict parabolicity is assumed, presents both classes of systems where all weak solutions are in fact more regular, and examples of systems with weak solutions which develop singularities in finite time. Our main result is the extension of a regularity result due to Kalita to the stochastic case. Concerning the examples with singular solutions (outside the setting of Kalita's regularity result), we do not know whether stochastic noise may prevent the emergence of singularities, as it happens for easier PDEs. We can only prove that, for a linear stochastic parabolic system with coefficients outside the previous regularity theory, the expected value of the solution is not singular.

  3. Asymptotic behavior of solutions to nonlinear parabolic equation with nonlinear boundary conditions

    Directory of Open Access Journals (Sweden)

    Diabate Nabongo

    2008-01-01

    Full Text Available We show that solutions of a nonlinear parabolic equation of second order with nonlinear boundary conditions approach zero as t approaches infinity. Also, under additional assumptions, the solutions behave as a function determined here.

  4. A Microscopic Convexity Principle for Spacetime Convex Solutions of Fully Nonlinear Parabolic Equations

    Institute of Scientific and Technical Information of China (English)

    Chuan Qiang CHEN; Bo Wen HU

    2013-01-01

    We study microscopic spacetime convexity properties of fully nonlinear parabolic partial differential equations.Under certain general structure condition,we establish a constant rank theorem for the spacetime convex solutions of fully nonlinear parabolic equations.At last,we consider the parabolic convexity of solutions to parabolic equations and the convexity of the spacetime second fundamental form of geometric flows.

  5. NEW ALTERNATING DIRECTION FINITE ELEMENT SCHEME FOR NONLINEAR PARABOLIC EQUATION

    Institute of Scientific and Technical Information of China (English)

    崔霞

    2002-01-01

    A new alternating direction (AD) finite element (FE) scheme for 3-dimensional nonlinear parabolic equation and parabolic integro-differential equation is studied. By using AD,the 3-dimensional problem is reduced to a family of single space variable problems, calculation work is simplified; by using FE, high accuracy is kept; by using various techniques for priori estimate for differential equations such as inductive hypothesis reasoning, the difficulty arising from the nonlinearity is treated. For both FE and ADFE schemes, the convergence properties are rigorously demonstrated, the optimal H1- and L2-norm space estimates and the O((△t)2) estimate for time variable are obtained.

  6. General difference schemes with intrinsic parallelism for nonlinear parabolic systems

    Institute of Scientific and Technical Information of China (English)

    周毓麟; 袁光伟

    1997-01-01

    The boundary value problem for nonlinear parabolic system is solved by the finite difference method with intrinsic parallelism. The existence of the discrete vector solution for the general finite difference schemes with intrinsic parallelism is proved by the fixed-point technique in finite-dimensional Euclidean space. The convergence and stability theorems of the discrete vector solutions of the nonlinear difference system with intrinsic parallelism are proved. The limitation vector function is just the unique generalized solution of the original problem for the parabolic system.

  7. Stability of Difference Schemes for Fractional Parabolic PDE with the Dirichlet-Neumann Conditions

    Directory of Open Access Journals (Sweden)

    Zafer Cakir

    2012-01-01

    boundary conditions are presented. Stability estimates and almost coercive stability estimates with ln (1/(+|ℎ| for the solution of these difference schemes are obtained. A procedure of modified Gauss elimination method is used for solving these difference schemes of one-dimensional fractional parabolic partial differential equations.

  8. Nonlinear Hyperbolic-Parabolic System Modeling Some Biological Phenomena

    Institute of Scientific and Technical Information of China (English)

    WU Shaohua; CHEN Hua

    2011-01-01

    In this paper, we study a nonlinear hyperbolic-parabolic system modeling some biological phenomena. By semigroup theory and Leray-Schauder fixed point argument, the local existence and uniqueness of the weak solutions for this system are proved. For the spatial dimension N = 1, the global existence of the weak solution will be established by the bootstrap argument.

  9. Asymptotic analysis of a coupled nonlinear parabolic system

    Institute of Scientific and Technical Information of China (English)

    Lan QIAO; Sining ZHENG

    2008-01-01

    This paper deals with asymptotic analysis of a parabolic system with inner absorptions and coupled nonlinear boundary fluxes. Three simultaneous blow-up rates are established under different dominations of nonlinearities, and simply represented in a characteristic algebraic system introduced for the problem. In particular, it is observed that two of the multiple blow-up rates are absorption-related. This is substantially different from those for nonlinear parabolic problems with absorptions in all the previous literature, where the blow-up rates were known as absorption-independent. The results of the paper rely on the scaling method with a complete classification for the nonlinear parameters of the model. The first example of absorption-related blow-up rates was recently proposed by the authors for a coupled parabolic system with mixed type nonlinearities. The present paper shows that the newly observed phenomena of absorption-related blow-up rates should be due to the coupling mechanism, rather than the mixed type nonlinearities.

  10. Inverse Coefficient Problems for Nonlinear Parabolic Differential Equations

    Institute of Scientific and Technical Information of China (English)

    Yun Hua OU; Alemdar HASANOV; Zhen Hai LIU

    2008-01-01

    This paper is devoted to a class of inverse problems for a nonlinear parabolic differential equation.The unknown coefficient of the equation depends on the gradient of the solution and belongs to a set of admissible coefficients.It is proved that the convergence of solutions for the corresponding direct problems continuously depends on the coefficient convergence.Based on this result the existence of a quasisolution of the inverse problem is obtained in the appropriate class of admissible coefficients.

  11. Local H\\"older continuity for doubly nonlinear parabolic equations

    CERN Document Server

    Kuusi, Tuomo; Urbano, José Miguel

    2010-01-01

    We give a proof of the H\\"older continuity of weak solutions of certain degenerate doubly nonlinear parabolic equations in measure spaces. We only assume the measure to be a doubling non-trivial Borel measure which supports a Poincar\\'e inequality. The proof discriminates between large scales, for which a Harnack inequality is used, and small scales, that require intrinsic scaling methods.

  12. Some remarks on singular solutions of nonlinear elliptic equations. III: viscosity solutions, including parabolic operators

    CERN Document Server

    Caffarelli, Luis; Nirenberg, Louis

    2011-01-01

    The paper concerns singular solutions of nonlinear elliptic equations, which include removable singularities for viscosity solutions, a strengthening of the Hopf Lemma including parabolic equations, Strong maximum principle and Hopf Lemma for viscosity solutions including also parabolic equations.

  13. A fast algorithm for parabolic PDE-based inverse problems based on Laplace transforms and flexible Krylov solvers

    Energy Technology Data Exchange (ETDEWEB)

    Bakhos, Tania, E-mail: taniab@stanford.edu [Institute for Computational and Mathematical Engineering, Stanford University (United States); Saibaba, Arvind K. [Department of Electrical and Computer Engineering, Tufts University (United States); Kitanidis, Peter K. [Institute for Computational and Mathematical Engineering, Stanford University (United States); Department of Civil and Environmental Engineering, Stanford University (United States)

    2015-10-15

    We consider the problem of estimating parameters in large-scale weakly nonlinear inverse problems for which the underlying governing equations is a linear, time-dependent, parabolic partial differential equation. A major challenge in solving these inverse problems using Newton-type methods is the computational cost associated with solving the forward problem and with repeated construction of the Jacobian, which represents the sensitivity of the measurements to the unknown parameters. Forming the Jacobian can be prohibitively expensive because it requires repeated solutions of the forward and adjoint time-dependent parabolic partial differential equations corresponding to multiple sources and receivers. We propose an efficient method based on a Laplace transform-based exponential time integrator combined with a flexible Krylov subspace approach to solve the resulting shifted systems of equations efficiently. Our proposed solver speeds up the computation of the forward and adjoint problems, thus yielding significant speedup in total inversion time. We consider an application from Transient Hydraulic Tomography (THT), which is an imaging technique to estimate hydraulic parameters related to the subsurface from pressure measurements obtained by a series of pumping tests. The algorithms discussed are applied to a synthetic example taken from THT to demonstrate the resulting computational gains of this proposed method.

  14. Properties of positive solutions to a nonlinear parabolic problem

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    This paper deals with the properties of positive solutions to a quasilinear parabolic equation with the nonlinear absorption and the boundary flux. The necessary and sufficient conditions on the global existence of solutions are described in terms of different parameters appearing in this problem. Moreover, by a result of Chasseign and Vazquez and the comparison principle, we deduce that the blow-up occurs only on the boundary (?)Ω. In addition, for a bounded Lipschitz domainΩ, we establish the blow-up rate estimates for the positive solution to this problem with a= 0.

  15. Dynamics of parabolic problems with memory. Subcritical and critical nonlinearities

    Science.gov (United States)

    Li, Xiaojun

    2016-08-01

    In this paper, we study the long-time behavior of the solutions of non-autonomous parabolic equations with memory in cases when the nonlinear term satisfies subcritical and critical growth conditions. In order to do this, we show that the family of processes associated to original systems with heat source f(x, t) being translation bounded in Lloc 2 ( R ; L 2 ( Ω ) ) is dissipative in higher energy space M α , 0 < α ≤ 1, and possesses a compact uniform attractor in M 0 .

  16. Preconditioned implicit PDE solvers for degenerate parabolic equations with applications to monument conservation

    CERN Document Server

    Semplice, Matteo; Serra-Capizzano, Stefano

    2009-01-01

    We are interested in the mathematical models for the description, in a quantitative way, of the damages induced on the monuments by the action of specific pollutants. A quantitative knowledge of such a degradation is of great importance in precise scheduling of cleaning or deeper restoration works. The analytical study of the solution of the considered models has been conducted and validated by the group of Natalini in Rome. The latter reveals important and partly unexpected features of the time evolution of the damages, but only in an asymptotic sense, that is for large times. However, for a short window of time, we need to couple such a study with a numerical approximation scheme in order to have a quantitative forecast at any time of interest. The novel contribution of this paper relies in the proposal of a fully implicit numerical method, in its convergence/stability analysis, and in the study of the related computational cost. In fact, due to the nonlinear nature of the underlying mathematical model, the...

  17. Interpolation inequalities for weak solutions of nonlinear parabolic systems

    Directory of Open Access Journals (Sweden)

    Floridia Giuseppe

    2011-01-01

    Full Text Available Abstract The authors investigate differentiability of the solutions of nonlinear parabolic systems of order 2 m in divergence form of the following type ∑ | α | ≤ m ( - 1 | α | D α a α X , D u + ∂ u ∂ t = 0 . The achieved results are inspired by the paper of Marino and Maugeri 2008, and the methods there applied. This note can be viewed as a continuation of the study of regularity properties for solutions of systems started in Ragusa 2002, continued in Ragusa 2003 and Floridia and Ragusa 2012 and also as a generalization of the paper by Capanato and Cannarsa 1981, where regularity properties of the solutions of nonlinear elliptic systems with quadratic growth are reached. Mathematics Subject Classification (2000 Primary 35K41, 35K55. Secondary 35B65, 35B45, 35D10

  18. Positive solutions of quasilinear parabolic systems with nonlinear boundary conditions

    Science.gov (United States)

    Pao, C. V.; Ruan, W. H.

    2007-09-01

    The aim of this paper is to investigate the existence, uniqueness, and asymptotic behavior of solutions for a coupled system of quasilinear parabolic equations under nonlinear boundary conditions, including a system of quasilinear parabolic and ordinary differential equations. Also investigated is the existence of positive maximal and minimal solutions of the corresponding quasilinear elliptic system as well as the uniqueness of a positive steady-state solution. The elliptic operators in both systems are allowed to be degenerate in the sense that the density-dependent diffusion coefficients Di(ui) may have the property Di(0)=0 for some or all i. Our approach to the problem is by the method of upper and lower solutions and its associated monotone iterations. It is shown that the time-dependent solution converges to the maximal solution for one class of initial functions and it converges to the minimal solution for another class of initial functions; and if the maximal and minimal solutions coincide then the steady-state solution is unique and the time-dependent solution converges to the unique solution. Applications of these results are given to three model problems, including a porous medium type of problem, a heat-transfer problem, and a two-component competition model in ecology. These applications illustrate some very interesting distinctive behavior of the time-dependent solutions between density-independent and density-dependent diffusions.

  19. Progress of adaptive finite element(FE) method in solving nonlinear partial differential equation(PDE)

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Scientific computation is widely used in multiple cross-disciplinary areas. Most of the issues coming from this area finally result in solving PDE. In the process of solving PDE, the meshes are firstly generated within the area where PDE is functional; then, the methods of FE,Finite Difference (FD), and Finite Volume (FV) are applied on the meshes to solve the PDE.

  20. A SECOND ORDER DIFFERENCE SCHEME WITH NONUNIFORM MESHES FOR NONLINEAR PARABOLIC SYSTEM

    Institute of Scientific and Technical Information of China (English)

    WAN Zhengsu; CHEN Guangnan

    2003-01-01

    In this paper, a difference scheme with nonuniform meshes is established for the initial-boundary problem of the nonlinear parabolic system. It is proved that the difference scheme is second order convergent in spacestep and timestep.

  1. LEAST-SQUARES MIXED FINITE ELEMENT METHODS FOR NONLINEAR PARABOLIC PROBLEMS

    Institute of Scientific and Technical Information of China (English)

    Dan-ping Yang

    2002-01-01

    Two least-squares mixed finite element schemes are formulated to solve the initialboundary value problem of a nonlinear parabolic partial differential equation and the convergence of these schemes are analyzed.

  2. EXISTENCE AND UNIQUENESS OF WEAK SOLUTIONS FOR A NONLINEAR PARABOLIC EQUATION RELATED TO IMAGE ANALYSIS

    Institute of Scientific and Technical Information of China (English)

    Wang Lihe; Zhou Shulin

    2006-01-01

    In this paper we establish the existence and uniqueness of weak solutions for the initial-boundary value problem of a nonlinear parabolic partial differential equation, which is related to the Malik-Perona model in image analysis.

  3. Time-Periodic Solution of a 2D Fourth-Order Nonlinear Parabolic Equation

    Indian Academy of Sciences (India)

    Xiaopeng Zhao; Changchun Liu

    2014-08-01

    By using the Galerkin method, we study the existence and uniqueness of time-periodic generalized solutions and time-periodic classical solutions to a fourth-order nonlinear parabolic equation in 2D case.

  4. Observation of spectral self-imaging by nonlinear parabolic cross-phase modulation.

    Science.gov (United States)

    Lei, Lei; Huh, Jeonghyun; Cortés, Luis Romero; Maram, Reza; Wetzel, Benjamin; Duchesne, David; Morandotti, Roberto; Azaña, José

    2015-11-15

    We report an experimental demonstration of spectral self-imaging on a periodic frequency comb induced by a nonlinear all-optical process, i.e., parabolic cross-phase modulation in a highly nonlinear fiber. The comb free spectral range is reconfigured by simply tuning the temporal period of the pump parabolic pulse train. In particular, undistorted FSR divisions by factors of 2 and 3 are successfully performed on a 10 GHz frequency comb, realizing new frequency combs with an FSR of 5 and 3.3 GHz, respectively. The pump power requirement associated to the SSI phenomena is also shown to be significantly relaxed by the use of dark parabolic pulses.

  5. Homogenization of attractors for a class of nonlinear parabolic equations

    Institute of Scientific and Technical Information of China (English)

    WANG Guo-lian; ZHANG Xing-you

    2004-01-01

    The relation between the global attractors Aε for a calss of quasilinear parabolic equations and the global attractor A0for the homogenized equation is discussed, and an explicit error estimate between Aε and A0 is given.

  6. A Comparison of PDE-based Non-Linear Anisotropic Diffusion Techniques for Image Denoising

    Energy Technology Data Exchange (ETDEWEB)

    Weeratunga, S K; Kamath, C

    2003-01-06

    PDE-based, non-linear diffusion techniques are an effective way to denoise images. In a previous study, we investigated the effects of different parameters in the implementation of isotropic, non-linear diffusion. Using synthetic and real images, we showed that for images corrupted with additive Gaussian noise, such methods are quite effective, leading to lower mean-squared-error values in comparison with spatial filters and wavelet-based approaches. In this paper, we extend this work to include anisotropic diffusion, where the diffusivity is a tensor valued function which can be adapted to local edge orientation. This allows smoothing along the edges, but not perpendicular to it. We consider several anisotropic diffusivity functions as well as approaches for discretizing the diffusion operator that minimize the mesh orientation effects. We investigate how these tensor-valued diffusivity functions compare in image quality, ease of use, and computational costs relative to simple spatial filters, the more complex bilateral filters, wavelet-based methods, and isotropic non-linear diffusion based techniques.

  7. PDE-based nonlinear diffusion techniques for denoising scientific and industrial images: an empirical study

    Science.gov (United States)

    Weeratunga, Sisira K.; Kamath, Chandrika

    2002-05-01

    Removing noise from data is often the first step in data analysis. Denoising techniques should not only reduce the noise, but do so without blurring or changing the location of the edges. Many approaches have been proposed to accomplish this; in this paper, we focus on one such approach, namely the use of non-linear diffusion operators. This approach has been studied extensively from a theoretical viewpoint ever since the 1987 work of Perona and Malik showed that non-linear filters outperformed the more traditional linear Canny edge detector. We complement this theoretical work by investigating the performance of several isotropic diffusion operators on test images from scientific domains. We explore the effects of various parameters such as the choice of diffusivity function, explicit and implicit methods for the discretization of the PDE, and approaches for the spatial discretization of the non-linear operator etc. We also compare these schemes with simple spatial filters and the more complex wavelet-based shrinkage techniques. Our empirical results show that, with an appropriate choice of parameters, diffusion-based schemes can be as effective as competitive techniques.

  8. Comparison of PDE-based non-linear anistropic diffusion techniques for image denoising

    Science.gov (United States)

    Weeratunga, Sisira K.; Kamath, Chandrika

    2003-05-01

    PDE-based, non-linear diffusion techniques are an effective way to denoise images.In a previous study, we investigated the effects of different parameters in the implementation of isotropic, non-linear diffusion. Using synthetic and real images, we showed that for images corrupted with additive Gaussian noise, such methods are quite effective, leading to lower mean-squared-error values in comparison with spatial filters and wavelet-based approaches. In this paper, we extend this work to include anisotropic diffusion, where the diffusivity is a tensor valued function which can be adapted to local edge orientation. This allows smoothing along the edges, but not perpendicular to it. We consider several anisotropic diffusivity functions as well as approaches for discretizing the diffusion operator that minimize the mesh orientation effects. We investigate how these tensor-valued diffusivity functions compare in image quality, ease of use, and computational costs relative to simple spatial filters, the more complex bilateral filters, wavelet-based methods, and isotropic non-linear diffusion based techniques.

  9. Difference schemes for fully nonlinear pseudo-parabolic systems with two space dimensions

    Institute of Scientific and Technical Information of China (English)

    周毓麟; 袁光伟

    1996-01-01

    The first boundary value problem for the fully nonlinear pseudoparabolic systems of partial differential equations with two space dimensions by the finite difference method is studied. The existence and uniqueness of the discrete vector solutions for the difference systems are established by the fixed point technique. The stability and convergence of the discrete vector solutions of the difference schemes to the vector solutions of the original boundary problem of the fully nonlinear pseudo-parabolic system are obtained by way of a priori estimation. Here the unique smooth vector solution of the original problems for the fully nonlinear pseudo-parabolic system is assumed. Moreover, by the method used here, it can be proved that analogous results hold for fully nonlinear pseudo-parabolic system with three space dimensions, and improve the known results in the case of one space dimension.

  10. ADFE METHOD WITH HIGH ACCURACY FOR NONLINEAR PARABOLIC INTEGRO-DIFFERENTIAL SYSTEM WITH NONLINEAR BOUNDARY CONDITIONS

    Institute of Scientific and Technical Information of China (English)

    崔霞

    2002-01-01

    Alternating direction finite element (ADFE) scheme for d-dimensional nonlinear system of parabolic integro-differential equations is studied. By using a local approximation based on patches of finite elements to treat the capacity term qi(u), decomposition of the coefficient matrix is realized; by using alternating direction, the multi-dimensional problem is reduced to a family of single space variable problems, calculation work is simplified; by using finite element method, high accuracy for space variant is kept; by using inductive hypothesis reasoning, the difficulty coming from the nonlinearity of the coefficients and boundary conditions is treated; by introducing Ritz-Volterra projection, the difficulty coming from the memory term is solved. Finally, by using various techniques for priori estimate for differential equations, the unique resolvability and convergence properties for both FE and ADFE schemes are rigorously demonstrated, and optimal H1 and L2norm space estimates and O((△t)2) estimate for time variant are obtained.

  11. Hazardous Continuation Backward in Time in Nonlinear Parabolic Equations, and an Experiment in Deblurring Nonlinearly Blurred Imagery.

    Science.gov (United States)

    Carasso, Alfred S

    2013-01-01

    Identifying sources of ground water pollution, and deblurring nanoscale imagery as well as astronomical galaxy images, are two important applications involving numerical computation of parabolic equations backward in time. Surprisingly, very little is known about backward continuation in nonlinear parabolic equations. In this paper, an iterative procedure originating in spectroscopy in the 1930's, is adapted into a useful tool for solving a wide class of 2D nonlinear backward parabolic equations. In addition, previously unsuspected difficulties are uncovered that may preclude useful backward continuation in parabolic equations deviating too strongly from the linear, autonomous, self adjoint, canonical model. This paper explores backward continuation in selected 2D nonlinear equations, by creating fictitious blurred images obtained by using several sharp images as initial data in these equations, and capturing the corresponding solutions at some positive time T. Successful backward continuation from t=T to t = 0, would recover the original sharp image. Visual recognition provides meaningful evaluation of the degree of success or failure in the reconstructed solutions. Instructive examples are developed, illustrating the unexpected influence of certain types of nonlinearities. Visually and statistically indistinguishable blurred images are presented, with vastly different deblurring results. These examples indicate that how an image is nonlinearly blurred is critical, in addition to the amount of blur. The equations studied represent nonlinear generalizations of Brownian motion, and the blurred images may be interpreted as visually expressing the results of novel stochastic processes.

  12. A Discrete Model for an Ill-Posed Nonlinear Parabolic PDE

    Science.gov (United States)

    2001-02-23

    BA9]%J\\^C/CacFGHiSamFIJBXQA`acFIJB\\/_FICM,k� ADHd � PQA`]¢J\\^M,HQ]`U(£�XQ\\/C^A�¤*�,Ut�¥¦XQFG]�F>EGA`@¢idZQ\\t�7AD@BA`HJracMGJB\\^EIFIJB\\/M,H J...ôR°_kV_?TV_kVU[^V_?ex��V_?m�[�Y\\[�hk[�Y\\�Uex¤~h_?��[�Y\\V_�L a@_öµ ߨ��|�z��bu^y÷p uUp?�Í�~p�Soq�c�0oq��|���oq�PrU� ì�g�^ gp |���oq��Søg�?oU

  13. Partition of Unity for a Class of Nonlinear Parabolic Equation on Overlapping Non-Matching Grids

    Institute of Scientific and Technical Information of China (English)

    Qisheng Wang; Kang Deng; Zhiguang Xiong; Yunqing Huang

    2007-01-01

    A class of nonlinear parabolic equation on a polygonal domain Ω ( ) R2 is investigated in this paper. We introduce a finite element method on overlapping non-matching grids for the nonlinear parabolic equation based on the partition of unity method. We give the construction and convergence analysis for the semi-discrete and the fully discrete finite element methods. Moreover, we prove that the error of the discrete variational problem has good approximation properties. Our results are valid for any spatial dimensions. A numerical example to illustrate the theoretical results is also given.

  14. CONVERGENCE OF THE CRANK-NICOLSON/NEWTON SCHEME FOR NONLINEAR PARABOLIC PROBLEM

    Institute of Scientific and Technical Information of China (English)

    Xinlong FENG; Yinnian HE

    2016-01-01

    In this paper, the Crank-Nicolson/Newton scheme for solving numerically second-order nonlinear parabolic problem is proposed. The standard Galerkin finite element method based on P2 conforming elements is used to the spatial discretization of the problem and the Crank-Nicolson/Newton scheme is applied to the time discretization of the resulted finite element equations. Moreover, assuming the appropriate regularity of the exact solution and the finite element solution, we obtain optimal error estimates of the fully discrete Crank-Nicolson/Newton scheme of nonlinear parabolic problem. Finally, numerical experiments are presented to show the effcient performance of the proposed scheme.

  15. Weak Solution to a Parabolic Nonlinear System Arising in Biological Dynamic in the Soil

    Directory of Open Access Journals (Sweden)

    Côme Goudjo

    2011-01-01

    Full Text Available We study a nonlinear parabolic system governing the biological dynamic in the soil. We prove global existence (in time and uniqueness of weak and positive solution for this reaction-diffusion semilinear system in a bounded domain, completed with homogeneous Neumann boundary conditions and positive initial conditions.

  16. Existence of Renormalized Solutions for p(x-Parabolic Equation with three unbounded nonlinearities

    Directory of Open Access Journals (Sweden)

    Youssef Akdim

    2016-04-01

    Full Text Available In this article, we study the existence of renormalized solution for the nonlinear $p(x$-parabolic problem of the form:\\\\ $\\begin{cases} \\frac{\\partial b(x,u}{\\partial t} - div (a(x,t,u,\

  17. THE FINITE ELEMENT METHODS FOR A CLASS OF NONLINEAR PARABOLIC EQUATIONS

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Error estimates are established for the finite dement methods to solve a class of second or der nonlinear parabolic equations. Optimal rates of convergence in L2-and H1-norms are derived. Meanwhile,the schenes are second order correct in time.

  18. SEMIDISCRETIZATION IN SPACE OF NONLINEAR DEGENERATE PARABOLIC EQUATIONS WITH BLOW-UP OF THE SOLUTIONS

    Institute of Scientific and Technical Information of China (English)

    Tetsuya Ishiwata; Masayoshi Tsutsumi

    2000-01-01

    Semidiscretization in space of nonlinear degenerate parabolic equations of nondivergent form is presented, under zero Dirichlet boundary condition. It is shown that semidiscrete solutions blow up in finite time. In particular, the asymptotic behavior of blowing-up solutions, is discussed precisely.

  19. THE EFFECT OF NUMERICAL INTEGRATION IN FINITE ELEMENT METHODS FOR NONLINEAR PARABOLIC EQUATIONS

    Institute of Scientific and Technical Information of China (English)

    N'guimbi; Germain

    2001-01-01

    Abstract. The effect of numerical integration in finite element methods applied to a class of nonlinear parabolic equations is considered and some sufficient conditions on the quadrature scheme to ensure that the order of convergence is unaltered in the presence of numerical integration are given. Optimal Lz and H1 estimates for the error and its time derivative are established.

  20. Explicit Nonlinear Finite Element Geometric Analysis of Parabolic Leaf Springs under Various Loads

    Science.gov (United States)

    Kong, Y. S.; Omar, M. Z.; Chua, L. B.; Abdullah, S.

    2013-01-01

    This study describes the effects of bounce, brake, and roll behavior of a bus toward its leaf spring suspension systems. Parabolic leaf springs are designed based on vertical deflection and stress; however, loads are practically derived from various modes especially under harsh road drives or emergency braking. Parabolic leaf springs must sustain these loads without failing to ensure bus and passenger safety. In this study, the explicit nonlinear dynamic finite element (FE) method is implemented because of the complexity of experimental testing A series of load cases; namely, vertical push, wind-up, and suspension roll are introduced for the simulations. The vertical stiffness of the parabolic leaf springs is related to the vehicle load-carrying capability, whereas the wind-up stiffness is associated with vehicle braking. The roll stiffness of the parabolic leaf springs is correlated with the vehicle roll stability. To obtain a better bus performance, two new parabolic leaf spring designs are proposed and simulated. The stress level during the loadings is observed and compared with its design limit. Results indicate that the newly designed high vertical stiffness parabolic spring provides the bus a greater roll stability and a lower stress value compared with the original design. Bus safety and stability is promoted, as well as the load carrying capability. PMID:24298209

  1. Explicit nonlinear finite element geometric analysis of parabolic leaf springs under various loads.

    Science.gov (United States)

    Kong, Y S; Omar, M Z; Chua, L B; Abdullah, S

    2013-01-01

    This study describes the effects of bounce, brake, and roll behavior of a bus toward its leaf spring suspension systems. Parabolic leaf springs are designed based on vertical deflection and stress; however, loads are practically derived from various modes especially under harsh road drives or emergency braking. Parabolic leaf springs must sustain these loads without failing to ensure bus and passenger safety. In this study, the explicit nonlinear dynamic finite element (FE) method is implemented because of the complexity of experimental testing A series of load cases; namely, vertical push, wind-up, and suspension roll are introduced for the simulations. The vertical stiffness of the parabolic leaf springs is related to the vehicle load-carrying capability, whereas the wind-up stiffness is associated with vehicle braking. The roll stiffness of the parabolic leaf springs is correlated with the vehicle roll stability. To obtain a better bus performance, two new parabolic leaf spring designs are proposed and simulated. The stress level during the loadings is observed and compared with its design limit. Results indicate that the newly designed high vertical stiffness parabolic spring provides the bus a greater roll stability and a lower stress value compared with the original design. Bus safety and stability is promoted, as well as the load carrying capability.

  2. Explicit Nonlinear Finite Element Geometric Analysis of Parabolic Leaf Springs under Various Loads

    Directory of Open Access Journals (Sweden)

    Y. S. Kong

    2013-01-01

    Full Text Available This study describes the effects of bounce, brake, and roll behavior of a bus toward its leaf spring suspension systems. Parabolic leaf springs are designed based on vertical deflection and stress; however, loads are practically derived from various modes especially under harsh road drives or emergency braking. Parabolic leaf springs must sustain these loads without failing to ensure bus and passenger safety. In this study, the explicit nonlinear dynamic finite element (FE method is implemented because of the complexity of experimental testing A series of load cases; namely, vertical push, wind-up, and suspension roll are introduced for the simulations. The vertical stiffness of the parabolic leaf springs is related to the vehicle load-carrying capability, whereas the wind-up stiffness is associated with vehicle braking. The roll stiffness of the parabolic leaf springs is correlated with the vehicle roll stability. To obtain a better bus performance, two new parabolic leaf spring designs are proposed and simulated. The stress level during the loadings is observed and compared with its design limit. Results indicate that the newly designed high vertical stiffness parabolic spring provides the bus a greater roll stability and a lower stress value compared with the original design. Bus safety and stability is promoted, as well as the load carrying capability.

  3. Fully Nonlinear Parabolic Equations and the Dini Condition

    Institute of Scientific and Technical Information of China (English)

    Xiong ZOU; Ya Zhe CHEN

    2002-01-01

    Interior regularity results for viscosity solutions of fully nonlinear uniformly parabolicequations under the Dini condition, which improve and generalize a result due to Kovats, are obtainedby the use of the approximation lemma.

  4. A MONOTONE DOMAIN DECOMPOSITION ALGORITHM FOR SOLVING WEIGHTED AVERAGE APPROXIMATIONS TO NONLINEAR SINGULARLY PERTURBED PARABOLIC PROBLEMS

    Institute of Scientific and Technical Information of China (English)

    Igor Boglaev; Matthew Hardy

    2008-01-01

    This paper presents and analyzes a monotone domain decomposition algorithm for solving nonlinear singularly perturbed reaction-diffusion problems of parabolic type.To solve the nonlinear weighted average finite difference scheme for the partial differential equation,we construct a monotone domain decomposition algorithm based on a Schwarz alternating method and a box-domain decomposition.This algorithm needs only to solve linear discrete systems at each iterative step and converges monotonically to the exact solution of the nonlinear discrete problem. The rate of convergence of the monotone domain decomposition algorithm is estimated.Numerical experiments are presented.

  5. Multigrid Reduction in Time for Nonlinear Parabolic Problems

    Energy Technology Data Exchange (ETDEWEB)

    Falgout, R. D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Manteuffel, T. A. [Univ. of Colorado, Boulder, CO (United States); O' Neill, B. [Univ. of Colorado, Boulder, CO (United States); Schroder, J. B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-01-04

    The need for parallel-in-time is being driven by changes in computer architectures, where future speed-ups will be available through greater concurrency, but not faster clock speeds, which are stagnant.This leads to a bottleneck for sequential time marching schemes, because they lack parallelism in the time dimension. Multigrid Reduction in Time (MGRIT) is an iterative procedure that allows for temporal parallelism by utilizing multigrid reduction techniques and a multilevel hierarchy of coarse time grids. MGRIT has been shown to be effective for linear problems, with speedups of up to 50 times. The goal of this work is the efficient solution of nonlinear problems with MGRIT, where efficient is defined as achieving similar performance when compared to a corresponding linear problem. As our benchmark, we use the p-Laplacian, where p = 4 corresponds to a well-known nonlinear diffusion equation and p = 2 corresponds to our benchmark linear diffusion problem. When considering linear problems and implicit methods, the use of optimal spatial solvers such as spatial multigrid imply that the cost of one time step evaluation is fixed across temporal levels, which have a large variation in time step sizes. This is not the case for nonlinear problems, where the work required increases dramatically on coarser time grids, where relatively large time steps lead to worse conditioned nonlinear solves and increased nonlinear iteration counts per time step evaluation. This is the key difficulty explored by this paper. We show that by using a variety of strategies, most importantly, spatial coarsening and an alternate initial guess to the nonlinear time-step solver, we can reduce the work per time step evaluation over all temporal levels to a range similar with the corresponding linear problem. This allows for parallel scaling behavior comparable to the corresponding linear problem.

  6. Parabolic Perturbation of a Nonlinear Hyperbolic Problem Arising in Physiology

    Science.gov (United States)

    Colli, P.; Grasselli, M.

    We study a transport-diffusion initial value problem where the diffusion codlicient is "small" and the transport coefficient is a time function depending on the solution in a nonlinear and nonlocal way. We show the existence and the uniqueness of a weak solution of this problem. Moreover we discuss its asymptotic behaviour as the diffusion coefficient goes to zero, obtaining a well-posed first-order nonlinear hyperbolic problem. These problems arise from mathematical models of muscle contraction in the framework of the sliding filament theory.

  7. Linear and nonlinear optical absorption coefficients of two-electron spherical quantum dot with parabolic potential

    Science.gov (United States)

    Çakır, Bekir; Yakar, Yusuf; Özmen, Ayhan

    2015-02-01

    Linear and nonlinear absorption coefficients of two-electron spherical quantum dot (QD) with parabolic potential are investigated in this paper. Wave functions and energy eigenvalues of the 1s2, 1s1p, 1s1d and 1s1f electronic states have been computed by using an optimization approach, which is a combination of Quantum Genetic Algorithm (QGA) and Hartree-Fock Roothaan (HFR) method. It is found that the strength of S→P transition is stronger than P→D and D→F transitions. Also the peak positions and amplitudes of the absorption coefficients are sensitive to the electron spin. It should be noted that the peak positions and amplitudes of absorption coefficients are strongly dependent on the parabolic potential. Additionally, dot radius, impurity charge, incident optical intensity and relaxation time have a great influence on the linear and nonlinear absorption coefficients.

  8. Linear and nonlinear optical absorption coefficients of two-electron spherical quantum dot with parabolic potential

    Energy Technology Data Exchange (ETDEWEB)

    Çakır, Bekir, E-mail: bcakir@selcuk.edu.tr [Physics Department, Faculty of Science, Selcuk University, Campus 42075, Konya (Turkey); Yakar, Yusuf, E-mail: yuyakar@yahoo.com [Physics Department, Faculty of Arts and Science, Aksaray University, Campus 68100, Aksaray (Turkey); Özmen, Ayhan [Physics Department, Faculty of Science, Selcuk University, Campus 42075, Konya (Turkey)

    2015-02-01

    Linear and nonlinear absorption coefficients of two-electron spherical quantum dot (QD) with parabolic potential are investigated in this paper. Wave functions and energy eigenvalues of the 1s{sup 2}, 1s1p, 1s1d and 1s1f electronic states have been computed by using an optimization approach, which is a combination of Quantum Genetic Algorithm (QGA) and Hartree–Fock Roothaan (HFR) method. It is found that the strength of S→P transition is stronger than P→D and D→F transitions. Also the peak positions and amplitudes of the absorption coefficients are sensitive to the electron spin. It should be noted that the peak positions and amplitudes of absorption coefficients are strongly dependent on the parabolic potential. Additionally, dot radius, impurity charge, incident optical intensity and relaxation time have a great influence on the linear and nonlinear absorption coefficients.

  9. Existence results for boundary problems for uniformly elliptic and parabolic fully nonlinear equations

    Directory of Open Access Journals (Sweden)

    M. G. Crandall

    1999-07-01

    Full Text Available We study existence of continuous weak (viscosity solutions of Dirichlet and Cauchy-Dirichlet problems for fully nonlinear uniformly elliptic and parabolic equations. Two types of results are obtained in contexts where uniqueness of solutions fails or is unknown. For equations with merely measurable coefficients we prove solvability of the problem, while in the continuous case we construct maximal and minimal solutions. Necessary barriers on external cones are also constructed.

  10. Classification of heteroclinic orbits of semilinear parabolic equations with a polynomial nonlinearity

    Directory of Open Access Journals (Sweden)

    Michael Robinson

    2011-05-01

    Full Text Available For a given semilinear parabolic equation with polynomial nonlinearity, many solutions blow up in finite time. For a certain class of these equations, we show that some of the solutions which do not blow up actually tend to equilibria. The characterizing property of such solutions is a finite energy constraint, which comes about from the fact that this class of equations can be written as the flow of the L^2 gradient of a certain functional.

  11. Implications of a wavepacket formulation for the nonlinear parabolized stability equations to hypersonic boundary layers

    Science.gov (United States)

    Kuehl, Joseph

    2016-11-01

    The parabolized stability equations (PSE) have been developed as an efficient and powerful tool for studying the stability of advection-dominated laminar flows. In this work, a new "wavepacket" formulation of the PSE is presented. This method accounts for the influence of finite-bandwidth-frequency distributions on nonlinear stability calculations. The methodology is motivated by convolution integrals and is found to appropriately represent nonlinear energy transfer between primary modes and harmonics, in particular nonlinear feedback, via a "nonlinear coupling coefficient." It is found that traditional discrete mode formulations overestimate nonlinear feedback by approximately 70%. This results in smaller maximum disturbance amplitudes than those observed experimentally. The new formulation corrects this overestimation, accounts for the generation of side lobes responsible for spectral broadening and results in disturbance saturation amplitudes consistent with experiment. A Mach 6 flared-cone example is presented. Support from the AFOSR Young Investigator Program via Grant FA9550-15-1-0129 is gratefully acknowledges.

  12. Existence and regularity of a global attractor for doubly nonlinear parabolic equations

    Directory of Open Access Journals (Sweden)

    Abderrahmane El Hachimi

    2002-05-01

    Full Text Available In this paper we consider a doubly nonlinear parabolic partial differential equation $$ frac{partial eta (u}{partial t}-Delta _{p}u+f(x,t,u=0 quad hbox{in }Omega imesmathbb{R}^{+}, $$ with Dirichlet boundary condition and initial data given. We prove the existence of a global compact attractor by using a dynamical system approach. Under additional conditions on the nonlinearities $Beta$, $f$, and on $p$, we prove more regularity for the global attractor and obtain stabilization results for the solutions.

  13. Existence and decay of solutions of some nonlinear parabolic variational inequalities

    Directory of Open Access Journals (Sweden)

    Mitsuhiro Nakao

    1980-01-01

    Full Text Available This paper discusses the existence and decay of solutions u(t of the variational inequality of parabolic type: ≧0for ∀v∈Lp([0,∞;V(p≧2 with v(t∈K a.e. in [0,∞, where K is a closed convex set of a separable uniformly convex Banach space V, A is a nonlinear monotone operator from V to V* and B is a nonlinear operator from Banach space W to W*. V and W are related as V⊂W⊂H for a Hilbert space H. No monotonicity assumption is made on B.

  14. Stability of the Shallow Axisymmetric Parabolic-Conic Bimetallic Shell by Nonlinear Theory

    Directory of Open Access Journals (Sweden)

    M. Jakomin

    2011-01-01

    Full Text Available In this contribution, we discuss the stress, deformation, and snap-through conditions of thin, axi-symmetric, shallow bimetallic shells of so-called parabolic-conic and plate-parabolic type shells loaded by thermal loading. According to the theory of the third order that takes into account the balance of forces on a deformed body, we present a model with a mathematical description of the system geometry, displacements, stress, and thermoelastic deformations. The equations are based on the large displacements theory. We numerically calculate the deformation curve and the snap-through temperature using the fourth-order Runge-Kutta method and a nonlinear shooting method. We show how the temperature of both snap-through depends on the point where one type of the rotational curve transforms into another.

  15. On the Uniqueness and Stability of Entropy Solutions of nonlinear degenerate parabolic Equations with rough Coefficients

    Energy Technology Data Exchange (ETDEWEB)

    Karlsen, Kenneth Hvistendahl; Risebro, Nils Henrik

    2000-05-01

    This paper studies nonlinear degenerate parabolic equations where the flux function does not depend Lipshitz continuously on the spatial position x. By properly adapting the 'doubling of variable' device due to Kruzkov and Carrillo, the authors prove a uniqueness result within the class of entropy solutions for the initial value problem. They also prove a result concerning the continuous dependence on the initial data and the flux function for degenerate parabolic equations with flux function of the form k(x)f(u), where k(x) is a vector-valued function and f(u) is a scalar function of the unknown scalar function u(x,t) which is sought.

  16. Blow-Up Analysis for a Quasilinear Degenerate Parabolic Equation with Strongly Nonlinear Source

    Directory of Open Access Journals (Sweden)

    Pan Zheng

    2012-01-01

    Full Text Available We investigate the blow-up properties of the positive solution of the Cauchy problem for a quasilinear degenerate parabolic equation with strongly nonlinear source ut=div(|∇um|p−2∇ul+uq,  (x,t∈RN×(0,T, where N≥1, p>2 , and m, l,  q>1, and give a secondary critical exponent on the decay asymptotic behavior of an initial value at infinity for the existence and nonexistence of global solutions of the Cauchy problem. Moreover, under some suitable conditions we prove single-point blow-up for a large class of radial decreasing solutions.

  17. On uniqueness and existence of entropy solutions of weakly coupled systems of nonlinear degenerate parabolic equations

    Directory of Open Access Journals (Sweden)

    Helge Holden

    2003-04-01

    Full Text Available We prove existence and uniqueness of entropy solutions for the Cauchy problem of weakly coupled systems of nonlinear degenerate parabolic equations. We prove existence of an entropy solution by demonstrating that the Engquist-Osher finite difference scheme is convergent and that any limit function satisfies the entropy condition. The convergence proof is based on deriving a series of a priori estimates and using a general $L^p$ compactness criterion. The uniqueness proof is an adaption of Kruzkov's ``doubling of variables'' proof. We also present a numerical example motivated by biodegradation in porous media.

  18. Stabilization of the solution of a doubly nonlinear parabolic equation

    Energy Technology Data Exchange (ETDEWEB)

    Andriyanova, È R [Ufa State Aviation Technical University, Ufa (Russian Federation); Mukminov, F Kh [Institute of Mathematics with Computing Centre, Ufa Science Centre, Russian Academy of Sciences, Ufa (Russian Federation)

    2013-09-30

    The method of Galerkin approximations is employed to prove the existence of a strong global (in time) solution of a doubly nonlinear parabolic equation in an unbounded domain. The second integral identity is established for Galerkin approximations, and passing to the limit in it an estimate for the decay rate of the norm of the solution from below is obtained. The estimates characterizing the decay rate of the solution as x→∞ obtained here are used to derive an upper bound for the decay rate of the solution with respect to time; the resulting estimate is pretty close to the lower one. Bibliography: 17 titles.

  19. PDE-based Non-Linear Diffusion Techniques for Denoising Scientific and Industrial Images: An Empirical Study

    Energy Technology Data Exchange (ETDEWEB)

    Weeratunga, S K; Kamath, C

    2001-12-20

    Removing noise from data is often the first step in data analysis. Denoising techniques should not only reduce the noise, but do so without blurring or changing the location of the edges. Many approaches have been proposed to accomplish this; in this paper, they focus on one such approach, namely the use of non-linear diffusion operators. This approach has been studied extensively from a theoretical viewpoint ever since the 1987 work of Perona and Malik showed that non-linear filters outperformed the more traditional linear Canny edge detector. They complement this theoretical work by investigating the performance of several isotropic diffusion operators on test images from scientific domains. They explore the effects of various parameters such as the choice of diffusivity function, explicit and implicit methods for the discretization of the PDE, and approaches for the spatial discretization of the non-linear operator etc. They also compare these schemes with simple spatial filters and the more complex wavelet-based shrinkage techniques. The empirical results show that, with an appropriate choice of parameters, diffusion-based schemes can be as effective as competitive techniques.

  20. Existence and Uniqueness of Very Singular Solution of a Degenerate Parabolic Equation with Nonlinear Convection

    Directory of Open Access Journals (Sweden)

    Jian Wang

    2009-01-01

    Full Text Available We here investigate the existence and uniqueness of the nontrivial, nonnegative solutions of a nonlinear ordinary differential equation: (|f′|p−2f′′+βrf′+αf+(fq′=0 satisfying a specific decay rate: lim⁡r→∞rα/βf(r=0 with α:=(p−1/(pq−2p+2 and β:=(q−p+1/(pq−2p+2. Here p>2 and q>p−1. Such a solution arises naturally when we study a very singular self-similar solution for a degenerate parabolic equation with nonlinear convection term ut=(|ux|p−2uxx+(uqx defined on the half line [0,+∞.

  1. Efficient implementation to numerically solve the nonlinear time fractional parabolic problems on unbounded spatial domain

    Science.gov (United States)

    Li, Dongfang; Zhang, Jiwei

    2016-10-01

    Anomalous diffusion behavior in many practical problems can be described by the nonlinear time-fractional parabolic problems on unbounded domain. The numerical simulation is a challenging problem due to the dependence of global information from time fractional operators, the nonlinearity of the problem and the unboundedness of the spacial domain. To overcome the unboundedness, conventional computational methods lead to extremely expensive costs, especially in high dimensions with a simple treatment of boundary conditions by making the computational domain large enough. In this paper, based on unified approach proposed in [25], we derive the efficient nonlinear absorbing boundary conditions (ABCs), which reformulates the problem on unbounded domain to an initial boundary value problem on bounded domain. To overcome nonlinearity, we construct a linearized finite difference scheme to solve the reduced nonlinear problem such that iterative methods become dispensable. And the stability and convergence of our linearized scheme are proved. Most important, we prove that the numerical solutions are bounded by the initial values with a constant coefficient, i.e., the constant coefficient is independent of the time. Overall, the computational cost can be significantly reduced comparing with the usual implicit schemes and a simple treatment of boundary conditions. Finally, numerical examples are given to demonstrate the efficiency of the artificial boundary conditions and theoretical results of the schemes.

  2. A lumped mass nonconforming finite element method for nonlinear parabolic integro-differential equations on anisotropic meshes

    Institute of Scientific and Technical Information of China (English)

    SHI Dong-yang; WANG Hui-min; LI Zhi-yan

    2009-01-01

    A lumped mass approximation scheme of a low order Crouzeix-Raviart type nonconforming triangular finite element is proposed to a kind of nonlinear parabolic integro-differential equations. The L2 error estimate is derived on anisotropic meshes without referring to the traditional nonclassical elliptic projection.

  3. EXISTENCE AND NON-EXISTENCE OF GLOBAL SOLUTIONS OF A DEGENERATE PARABOLIC SYSTEM WITH NONLINEAR BOUNDARY CONDITIONS

    Institute of Scientific and Technical Information of China (English)

    Sun Fuqin; Wang Mingxin

    2004-01-01

    In this paper, we study the non-negative solutions to a degenerate parabolic system with nonlinear boundary conditions in the multi-dimensional case.By the upper and lower solutions method, we give the conditions on the existence and non-existence of global solutions.

  4. A necessary and sufficient condition for finite speed of propagation in the theory of doubly nonlinear degenerate parabolic equations

    NARCIS (Netherlands)

    Gilding, B.H.; Kersner, R.

    1996-01-01

    A degenerate parabolic partial differential equation with a time derivative and first- and second-order derivatives with respect to one spatial variable is studied. The coefficients in the equation depend nonlinearly on both the unknown and the first spatial derivative of a function of the unknown.

  5. Existence of a Renormalised Solutions for a Class of Nonlinear Degenerated Parabolic Problems with L1 Data

    Institute of Scientific and Technical Information of China (English)

    AKDIM Y; BENNOUNA J; MEKKOUR M; REDWANE H

    2013-01-01

    We study the existence of renormalized solutions for a class of nonlinear degenerated parabolic problem.The Carathéodory function satisfying the coercivity condition,the growth condition and only the large monotonicity.The data belongs to L1(Q).

  6. Recent results and open problems on parabolic equations with gradient nonlinearities

    Directory of Open Access Journals (Sweden)

    Philippe Souplet

    2001-03-01

    Full Text Available We survey recent results and present a number of open problems concerning the large-time behavior of solutions of semilinear parabolic equations with gradient nonlinearities. We focus on the model equation with a dissipative gradient term $$u_t-Delta u=u^p-b|abla u|^q,$$ where $p$, $q>1$, $b>0$, with homogeneous Dirichlet boundary conditions. Numerous papers were devoted to this equation in the last ten years, and we compare the results with those known for the case of the pure power reaction-diffusion equation ($b=0$. In presence of the dissipative gradient term a number of new phenomena appear which do not occur when $b=0$. The questions treated concern: sufficient conditions for blowup, behavior of blowing up solutions, global existence and stability, unbounded global solutions, critical exponents, and stationary states.

  7. Large time behavior for solutions of nonlinear parabolic problems with sign-changing measure data

    Directory of Open Access Journals (Sweden)

    Francesco Petitta

    2008-09-01

    Full Text Available Let $Omegasubseteq mathbb{R}^N$ a bounded open set, $Ngeq 2$, and let $p>1$; in this paper we study the asymptotic behavior with respect to the time variable $t$ of the entropy solution of nonlinear parabolic problems whose model is $$displaylines{ u_{t}(x,t-Delta_{p} u(x,t=mu quad hbox{in } Omegaimes(0,infty,cr u(x,0=u_{0}(x quad hbox{in } Omega, }$$ where $u_0 in L^{1}(Omega$, and $muin mathcal{M}_{0}(Q$ is a measure with bounded variation over $Q=Omegaimes(0,infty$ which does not charge the sets of zero $p$-capacity; moreover we consider $mu$ that does not depend on time. In particular, we prove that solutions of such problems converge to stationary solutions.

  8. On the Aleksandrov-Bakel'man-Pucci Estimate for Some Elliptic and Parabolic Nonlinear Operators

    Science.gov (United States)

    Argiolas, Roberto; Charro, Fernando; Peral, Ireneo

    2011-12-01

    In this work we prove the Aleksandrov-Bakel'man-Pucci estimate for (possibly degenerate) nonlinear elliptic and parabolic equations of the form -div left( Fleft( nabla u(x)right) right) =fleft(xright) quad in Ω subset mathbb{R}n and ut(x,t)-div left( Fleft( nabla u(x,t)right) right) =fleft( x,tright) quad in Qsubset mathbb{R}^{n+1} for F a {fancyscript{C}^1} monotone field under some suitable conditions. Examples of applications such as the p-Laplacian and the Mean Curvature Flow are considered, as well as extensions of the general results to equations that are not in divergence form, such as the m-curvature flow.

  9. THE STUDY ON A KIND OF CONTROL SYSTEM WITH NONLINEAR PARABOLIC DISTRIBUTED PARAMETERS

    Institute of Scientific and Technical Information of China (English)

    周建军; 徐燕侯

    2002-01-01

    The modelling of one kind of nonlinear parabolic distributed parameter control system with moving boundary, which had extensive applications was presented. Two methods were used to investigate the basic characteristics of the system: 1 ) transforming the system in the variable domain into that in the fixed domain; 2) transforming the distributed parameter system into the lumped parameter system. It is found that there are two critical values for the control variable: the larger one determines whether or not the boundary would move, while the smaller one determines whether or not the boundary would stop automatically. For one-dimensional system of planar, cylindrical and spherical cases the definite solution problem can be expressed as a unified form. By means of the computer simulation the open-loop control system and close-cycle feedback control system have been investigated. Numerical results agree well with theoretical results. The computer simulation shows that the system is well posed, stable, measurable and controllable.

  10. THE UNCONDITIONAL STABILITY OF PARALLEL DIFFERENCE SCHEMES WITH SECOND ORDER CONVERGENCE FOR NONLINEAR PARABOLIC SYSTEM

    Institute of Scientific and Technical Information of China (English)

    Yuan Guangwei; Sheng Zhiqiang; Hang Xudeng

    2007-01-01

    For solving nonlinear parabolic equation on massive parallel computers,the construction of parallel difference schemes with simple design, high parallelism and unconditional stability and second order global accuracy in space, has long been desired.In the present work, a new kind of general parallel difference schemes for the nonlinear parabolic system is proposed. The general parallel difference schemes include, among others, two new parallel schemes. In one of them, to obtain the interface values on the interface of sub-domains an explicit scheme of Jacobian type is employed, and then the fully implicit scheme is used in the sub-domains. Here, in the explicit scheme of Jacobian type, the values at the points being adjacent to the interface points are taken as the linear combination of values of previous two time layers at the adjoining points of the inner interface. For the construction of another new parallel difference scheme,the main procedure is as follows. Firstly the linear combination of values of previous two time layers at the interface points among the sub-domains is used as the (Dirichlet)boundary condition for solving the sub-domain problems. Then the values in the subdomains are calculated by the fully implicit scheme. Finally the interface values are computed by the fully implicit scheme, and in fact these calculations of the last step are explicit since the values adjacent to the interface points have been obtained in the previous step. The existence, uniqueness, unconditional stability and the second order accuracy of the discrete vector solutions for the parallel difference schemes are proved.Numerical results are presented to examine the stability, accuracy and parallelism of the parallel schemes.

  11. On a nonlinear degenerate parabolic transport-diffusion equation with a discontinuous coefficient

    Directory of Open Access Journals (Sweden)

    John D. Towers

    2002-10-01

    Full Text Available We study the Cauchy problem for the nonlinear (possibly strongly degenerate parabolic transport-diffusion equation $$ partial_t u + partial_x (gamma(xf(u=partial_x^2 A(u, quad A'(cdotge 0, $$ where the coefficient $gamma(x$ is possibly discontinuous and $f(u$ is genuinely nonlinear, but not necessarily convex or concave. Existence of a weak solution is proved by passing to the limit as $varepsilondownarrow 0$ in a suitable sequence ${u_{varepsilon}}_{varepsilon>0}$ of smooth approximations solving the problem above with the transport flux $gamma(xf(cdot$ replaced by $gamma_{varepsilon}(xf(cdot$ and the diffusion function $A(cdot$ replaced by $A_{varepsilon}(cdot$, where $gamma_{varepsilon}(cdot$ is smooth and $A_{varepsilon}'(cdot>0$. The main technical challenge is to deal with the fact that the total variation $|u_{varepsilon}|_{BV}$ cannot be bounded uniformly in $varepsilon$, and hence one cannot derive directly strong convergence of ${u_{varepsilon}}_{varepsilon>0}$. In the purely hyperbolic case ($A'equiv 0$, where existence has already been established by a number of authors, all existence results to date have used a singular maolinebreak{}pping to overcome the lack of a variation bound. Here we derive instead strong convergence via a series of a priori (energy estimates that allow us to deduce convergence of the diffusion function and use the compensated compactness method to deal with the transport term. Submitted April 29, 2002. Published October 27, 2002. Math Subject Classifications: 35K65, 35D05, 35R05, 35L80 Key Words: Degenerate parabolic equation; nonconvex flux; weak solution; discontinuous coefficient; viscosity method; a priori estimates; compensated compactness

  12. On the Cauchy problem for a doubly nonlinear degenerate parabolic equation with strongly nonlinear sources

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    In this article, we consider the existence of local and global solution to the Cauchy problem of a doubly nonlinear equation. By introducing the norms |||f|||h and h, we give the suffcient and necessary conditions on the initial value to the existence of local solution of doubly nonlinear equation. Moreover some results on the global existence and nonexistence of solutions are considered.

  13. Can there be a general nonlinear PDE theory for the existence of solutions ?

    OpenAIRE

    2004-01-01

    Contrary to widespread perception, there is ever since 1994 a unified, general type independent theory for the existence of solutions for very large classes of nonlinear systems of PDEs. This solution method is based on the Dedekind order completion of suitable spaces of piece-wise smooth functions on the Euclidean domains of definition of the respective PDEs. The method can also deal with associated initial and/or boundary value problems. The solutions obtained can be assimilated with usual ...

  14. A local PDE model of aggregation formation in bacterial colonies

    Science.gov (United States)

    Chavy-Waddy, Paul-Christopher; Kolokolnikov, Theodore

    2016-10-01

    We study pattern formation in a model of cyanobacteria motion recently proposed by Galante, Wisen, Bhaya and Levy. By taking a continuum limit of their model, we derive a novel fourth-order nonlinear parabolic PDE equation that governs the behaviour of the model. This PDE is {{u}t}=-{{u}xx}-{{u}xxxx}+α {{≤ft(\\frac{{{u}x}{{u}xx}}{u}\\right)}x} . We then derive the instability thresholds for the onset of pattern formation. We also compute analytically the spatial profiles of the steady state aggregation density. These profiles are shown to be of the form \\text{sec}{{\\text{h}}p} where the exponent p is related to the parameters of the model. Full numerical simulations give a favorable comparison between the continuum and the underlying discrete system, and show that the aggregation profiles are stable above the critical threshold.

  15. Nonlinear Structural Analysis Methodology and Dynamics Scaling of Inflatable Parabolic Reflector Antenna Concepts

    Science.gov (United States)

    Sreekantamurthy, Tham; Gaspar, James L.; Mann, Troy; Behun, Vaughn; Pearson, James C., Jr.; Scarborough, Stephen

    2007-01-01

    Ultra-light weight and ultra-thin membrane inflatable antenna concepts are fast evolving to become the state-of-the-art antenna concepts for deep-space applications. NASA Langley Research Center has been involved in the structural dynamics research on antenna structures. One of the goals of the research is to develop structural analysis methodology for prediction of the static and dynamic response characteristics of the inflatable antenna concepts. This research is focused on the computational studies to use nonlinear large deformation finite element analysis to characterize the ultra-thin membrane responses of the antennas. Recently, structural analyses have been performed on a few parabolic reflector antennas of varying size and shape, which are referred in the paper as 0.3 meters subscale, 2 meters half-scale, and 4 meters full-scale antenna. The various aspects studied included nonlinear analysis methodology and solution techniques, ways to speed convergence in iterative methods, the sensitivities of responses with respect to structural loads, such as inflation pressure, gravity, and pretension loads in the ground and in-space conditions, and the ultra-thin membrane wrinkling characteristics. Several such intrinsic aspects studied have provided valuable insight into evaluation of structural characteristics of such antennas. While analyzing these structural characteristics, a quick study was also made to assess the applicability of dynamics scaling of the half-scale antenna. This paper presents the details of the nonlinear structural analysis results, and discusses the insight gained from the studies on the various intrinsic aspects of the analysis methodology. The predicted reflector surface characteristics of the three inflatable ultra-thin membrane parabolic reflector antenna concepts are presented as easily observable displacement fringe patterns with associated maximum values, and normal mode shapes and associated frequencies. Wrinkling patterns are

  16. Parabolized Stability Equations analysis of nonlinear interactions with forced eigenmodes to control subsonic jet instabilities

    Energy Technology Data Exchange (ETDEWEB)

    Itasse, Maxime, E-mail: Maxime.Itasse@onera.fr; Brazier, Jean-Philippe, E-mail: Jean-Philippe.Brazier@onera.fr; Léon, Olivier, E-mail: Olivier.Leon@onera.fr; Casalis, Grégoire, E-mail: Gregoire.Casalis@onera.fr [Onera - The French Aerospace Lab, F-31055 Toulouse (France)

    2015-08-15

    Nonlinear evolution of disturbances in an axisymmetric, high subsonic, high Reynolds number hot jet with forced eigenmodes is studied using the Parabolized Stability Equations (PSE) approach to understand how modes interact with one another. Both frequency and azimuthal harmonic interactions are analyzed by setting up one or two modes at higher initial amplitudes and various phases. While single mode excitation leads to harmonic growth and jet noise amplification, controlling the evolution of a specific mode has been made possible by forcing two modes (m{sub 1}, n{sub 1}), (m{sub 2}, n{sub 2}), such that the difference in azimuth and in frequency matches the desired “target” mode (m{sub 1} − m{sub 2}, n{sub 1} − n{sub 2}). A careful setup of the initial amplitudes and phases of the forced modes, defined as the “killer” modes, has allowed the minimizing of the initially dominant instability in the near pressure field, as well as its estimated radiated noise with a 15 dB loss. Although an increase of the overall sound pressure has been found in the range of azimuth and frequency analyzed, the present paper reveals the possibility to make the initially dominant instability ineffective acoustically using nonlinear interactions with forced eigenmodes.

  17. Nonlinear photoluminescence in monolayer WS2: parabolic emission and excitation fluence-dependent recombination dynamics.

    Science.gov (United States)

    Fan, Xiaopeng; Zheng, Weihao; Liu, Hongjun; Zhuang, Xiujuan; Fan, Peng; Gong, Yanfang; Li, Honglai; Wu, Xueping; Jiang, Ying; Zhu, Xiaoli; Zhang, Qinglin; Zhou, Hong; Hu, Wei; Wang, Xiao; Duan, Xiangfeng; Pan, Anlian

    2017-06-01

    Recombination dynamics during photoluminescence (PL) in two-dimensional (2D) semiconducting transition metal dichalcogenides (TMDs) are complicated and can be easily affected by the surroundings because of their atomically thin structures. Herein, we studied the excitation power and temperature dependence of the recombination dynamics on the chemical vapor deposition-grown monolayer WS2via a combination of Raman, PL, and time-resolved PL spectroscopies. We found a red shift and parabolic intensity increase in the PL emission of the monolayer WS2 with the increasing excitation power and the decay time constants corresponding to the recombination of trions and excitons from transient PL dynamics. We attributed the abovementioned nonlinear changes in the PL peak positions and intensities to the combination of increasing carrier interaction and band structure renormalization rather than to the thermal effect from a laser. Furthermore, the excitation power-dependent Raman measurements support our conclusion. These findings and understanding will provide important information for the development of TMD-based optoelectronics and photonics.

  18. Global Existence and Blow-up of Solutions for Parabolic Systems Involving Cross-Diffusions and Nonlinear Boundary Conditions

    Institute of Scientific and Technical Information of China (English)

    Xiu Hui YANG; Fu Cai LI; Chun Hong XIE

    2005-01-01

    In this paper, we investigate the positive solutions of strongly coupled nonlinear parabolic systems with nonlinear boundary conditions:({ut-α(u,v)△u=g(u,v),vt-b(u,v)△v=h(u,v),(e)u/(e)(g)=d(u,v),(e)u/(e)(g)=f(u,v),)Under appropriate hypotheses on the functions a, b, g, h, d and f, we obtain that the solutions may exist globally or blow up in finite time by utilizing upper and lower solution techniques.

  19. Nonlinear pulse compression of picosecond parabolic-like pulses synthesized with a long period fiber grating filter.

    Science.gov (United States)

    Krcmarík, David; Slavík, Radan; Park, Yongwoo; Azaña, José

    2009-04-27

    tract: We demonstrate high quality pulse compression at high repetition rates by use of spectral broadening of short parabolic-like pulses in a normally-dispersive highly nonlinear fiber (HNLF) followed by linear dispersion compensation with a conventional SMF-28 fiber. The key contribution of this work is on the use of a simple and efficient long-period fiber grating (LPFG) filter for synthesizing the desired parabolic-like pulses from sech(2)-like input optical pulses; this all-fiber low-loss filter enables reducing significantly the required input pulse power as compared with the use of previous all-fiber pulse re-shaping solutions (e.g. fiber Bragg gratings). A detailed numerical analysis has been performed in order to optimize the system's performance, including investigation of the optimal initial pulse shape to be launched into the HNLF fiber. We found that the pulse shape launched into the HNLF is critically important for suppressing the undesired wave breaking in the nonlinear spectral broadening process. The optimal shape is found to be independent on the parameters of normally dispersive HNLFs. In our experiments, 1.5-ps pulses emitted by a 10-GHz mode-locked laser are first reshaped into 3.2-ps parabolic-like pulses using our LPFG-based pulse reshaper. Flat spectrum broadening of the amplified initial parabolic-like pulses has been generated using propagation through a commercially-available HNLF. Pulses of 260 fs duration with satellite peak and pedestal suppression greater than 17 dB have been obtained after the linear dispersion compensation fiber. The generated pulses exhibit a 20-nm wide supercontinuum energy spectrum that has almost a square-like spectral profile with >85% of the pulse energy contained in its FWHM spectral bandwidth.

  20. Time-periodic Solution to a Nonlinear Parabolic Type Equation of Higher Order

    Institute of Scientific and Technical Information of China (English)

    Yan-ping Wang; You-lin Zhang

    2008-01-01

    In this paper, the existence and uniqueness of time-periodic generalized solutions and time-periodic classical solutions to a class of parabolic type equation of higher order are proved by Gaierkin method.

  1. Instability of positive periodic solutions for semilinear pseudo-parabolic equations with logarithmic nonlinearity

    Science.gov (United States)

    Ji, Shanming; Yin, Jingxue; Cao, Yang

    2016-11-01

    In this paper, we consider the periodic problem for semilinear heat equation and pseudo-parabolic equation with logarithmic source. After establishing the existence of positive periodic solutions, we discuss the instability of such solutions.

  2. Stability of the Shallow Axisymmetric Parabolic-Conic Bimetallic Shell by Nonlinear Theory

    OpenAIRE

    M. Jakomin; Kosel, F.

    2011-01-01

    In this contribution, we discuss the stress, deformation, and snap-through conditions of thin, axi-symmetric, shallow bimetallic shells of so-called parabolic-conic and plate-parabolic type shells loaded by thermal loading. According to the theory of the third order that takes into account the balance of forces on a deformed body, we present a model with a mathematical description of the system geometry, displacements, stress, and thermoelastic deformations. The equations are based on the lar...

  3. THE DIRICHLET PROBLEM AND NEUMANN PROBLEM FOR NONLINEAR PARABOLIC SYSTEMS OF SECOND ORDER EQUATIONS WITH MEASURABLE COEFFICIENTS IN A HIGHER DIMENSIONAL DOMAIN

    Institute of Scientific and Technical Information of China (English)

    WEN Guochun; HUANG Sha; QIAO Yuying

    2001-01-01

    In 1988, Yu. A. Alkhutov and I. T. Mamedov discussed the solvability of the Dirichlet problem for linear uniformly parabolic equations with measurable coefficients where the coefficients satisfy the condition In this paper, we try to generalize the results of Alkhutov and Mamedov to nonlinear uni-formly parabolic systems of second order equations with measurable coefficients; moreover,we also discuss the solvability of the Neumann problem for the above systems.

  4. Uniform blow-up profiles and boundary layer for a parabolic system with localized nonlinear reaction terms

    Institute of Scientific and Technical Information of China (English)

    LI Huiling; WANG Mingxin

    2005-01-01

    This paper deals with the blow-up properties of the solution to a semilinear parabolic system with localized nonlinear reaction terms, subject to the null Dirichlet boundary condition. We first give sufficient conditions for that the classical solution blows up in the finite time, secondly give necessary conditions and a sufficient condition for that two components blow up simultaneously, and then obtain the uniform blow-up profiles in the interior. Finally we describe the asymptotic behavior of the blow-up solution in the boundary layer.

  5. Nonlinear parabolic equations with blowing-up coefficients with respect to the unknown and with soft measure data

    Directory of Open Access Journals (Sweden)

    Khaled Zaki

    2016-12-01

    Full Text Available We establish the existence of solutions for the nonlinear parabolic problem with Dirichlet homogeneous boundary conditions, $$ \\frac{\\partial u}{\\partial t} - \\sum_{i=1}^N\\frac{\\partial}{\\partial x_i} \\Big( d_i(u\\frac{\\partial u}{\\partial x_i} \\Big =\\mu,\\quad u(t=0=u_0, $$ in a bounded domain. The coefficients $d_i(s$ are continuous on an interval $]-\\infty,m[$, there exists an index p such that $d_p(u$ blows up at a finite value m of the unknown u, and $\\mu$ is a diffuse measure.

  6. On the uniqueness and existence of entropy solutions of weakly coupled systems of nonlinear degenerate parabolic equations

    Energy Technology Data Exchange (ETDEWEB)

    Holden, Helge; Karlsen, Kenneth H.; Risebro, Nils H.

    2002-04-01

    We prove uniqueness and existence of entropy solutions for the Cauchy problem of weakly coupled systems of nonlinear degenerate parabolic equations. The uniqueness proof is an adaption of Kruzkov's ''doubling of variables'' proof. We prove existence of an entropy solution by demonstrating that the Engquist-Osher finite difference scheme is convergent and that any limit function satisfies the entropy condition. The convergence proof is based on deriving a series of a priori estimates and using a general L{sup p} compactness criterion. We also present a numerical example motivated by biodegradation in porous media.

  7. Studies on the Second-Order Nonlinear Optical Properties of Parabolic and Semi-parabolic Quantum Wells with Applied Electric Fields

    Institute of Scientific and Technical Information of China (English)

    ZHANG Li; XIE Hong-Jing

    2004-01-01

    Within the framework of compact density matrix approach and iterative procedure, a detailed procedure for the calculation of the second-harmonic generation (SHG)susceptibility tensor is given in the electric-field-biased parabolic and semi-parabolic quantum wells (QWs). The simple analytical formula for the SHG susceptibility in the systems is also deduced. Numerical results on typical AlGaAs/GaAs materials show that, for the same effective width,the SHG susceptibility in semi-parabolic QW is larger than that in parabolic QW due to the self-asymmetry of the semiparabolic QW, and the applied electric field can make the SHG susceptibilities in both systems enhance remarkably.Moreover, the SHG susceptibility is also related to the parabolic confinement frequency and the relaxation rate of the systems.

  8. Cauchy problem and initial traces for a doubly nonlinear degenerate parabolic equation

    Institute of Scientific and Technical Information of China (English)

    赵俊宁; 徐中海

    1996-01-01

    The Cauchy problem and initial traces for the doubly degenerate parabolic equationsare studied. Under certain growth condition on the initial datum u0(x) as the existence of solution is proved. The results obtained are optimal in the dass of nonnegative locally bounded solution, for which a Harnack-type inequality holds.

  9. Cubic B-splines collocation method for solving nonlinear parabolic partial differential equations with Neumann boundary conditions

    Science.gov (United States)

    Mittal, R. C.; Jain, R. K.

    2012-12-01

    In this paper, a numerical method is proposed to approximate the solution of the nonlinear parabolic partial differential equation with Neumann's boundary conditions. The method is based on collocation of cubic B-splines over finite elements so that we have continuity of the dependent variable and its first two derivatives throughout the solution range. We apply cubic B-splines for spatial variable and its derivatives, which produce a system of first order ordinary differential equations. We solve this system by using SSP-RK3 scheme. The numerical approximate solutions to the nonlinear parabolic partial differential equations have been computed without transforming the equation and without using the linearization. Four illustrative examples are included to demonstrate the validity and applicability of the technique. In numerical test problems, the performance of this method is shown by computing L∞andL2error norms for different time levels. Results shown by this method are found to be in good agreement with the known exact solutions.

  10. Terascale Optimal PDE Simulations

    Energy Technology Data Exchange (ETDEWEB)

    David Keyes

    2009-07-28

    The Terascale Optimal PDE Solvers (TOPS) Integrated Software Infrastructure Center (ISIC) was created to develop and implement algorithms and support scientific investigations performed by DOE-sponsored researchers. These simulations often involve the solution of partial differential equations (PDEs) on terascale computers. The TOPS Center researched, developed and deployed an integrated toolkit of open-source, optimal complexity solvers for the nonlinear partial differential equations that arise in many DOE application areas, including fusion, accelerator design, global climate change and reactive chemistry. The algorithms created as part of this project were also designed to reduce current computational bottlenecks by orders of magnitude on terascale computers, enabling scientific simulation on a scale heretofore impossible.

  11. Nonlinear Maps Satisfying Derivability on the Parabolic Subalgebras of the Full Matrix Algebras

    Institute of Scientific and Technical Information of China (English)

    Zheng Xin CHEN; Yu E ZHAO

    2011-01-01

    Let F be a field of characteristic O,Mn(F) the full matrix algebra over F,t the subalgebra of Mn(F) consisting of all upper triangular matrices.Any subalgebra of Mn(F) containing t is called a parabolic subalgebra of Mn(F).Let P be a parabolic subalgebra of Mn(F).A map φ on P is said to satisfy derivability if φ(x·y) =φ(x).y+x·φ(y) for all x,y ∈ P,where φ is not necessarily linear.Note that a map satisfying derivability on P is not necessarily a derivation on P.In this paper,we prove that a map φ on P satisfies derivability if and only if φ is a sum of an inner derivation and an additive quasi-derivation on P.In particular,any derivation of parabolic subalgebras of Mn (F) is an inner derivation.

  12. Nonlinear Second-Order Partial Differential Equation-Based Image Smoothing Technique

    Directory of Open Access Journals (Sweden)

    Tudor Barbu

    2016-09-01

    Full Text Available A second-order nonlinear parabolic PDE-based restoration model is provided in this article. The proposed anisotropic diffusion-based denoising approach is based on some robust versions of the edge-stopping function and of the conductance parameter. Two stable and consistent approximation schemes are then developed for this differential model. Our PDE-based filtering technique achieves an efficient noise removal while preserving the edges and other image features. It outperforms both the conventional filters and also many PDE-based denoising approaches, as it results from the successful experiments and method comparison applied.

  13. Repeated games for eikonal equations, integral curvature flows and non-linear parabolic integro-differential equations

    CERN Document Server

    Imbert, Cyril

    2009-01-01

    The main purpose of this paper is to approximate several non-local evolution equations by zero-sum repeated games in the spirit of the previous works of Kohn and the second author (2006 and 2009): general fully non-linear parabolic integro-differential equations on the one hand, and the integral curvature flow of an interface (Imbert, 2008) on the other hand. In order to do so, we start by constructing such a game for eikonal equations whose speed has a non-constant sign. This provides a (discrete) deterministic control interpretation of these evolution equations. In all our games, two players choose positions successively, and their final payoff is determined by their positions and additional parameters of choice. Because of the non-locality of the problems approximated, by contrast with local problems, their choices have to "collect" information far from their current position. For integral curvature flows, players choose hypersurfaces in the whole space and positions on these hypersurfaces. For parabolic i...

  14. Critical Blow-Up and Global Existence for Discrete Nonlinear p-Laplacian Parabolic Equations

    Directory of Open Access Journals (Sweden)

    Soon-Yeong Chung

    2014-01-01

    Full Text Available The goal of this paper is to investigate the blow-up and the global existence of the solutions to the discrete p-Laplacian parabolic equation utx,t=Δp,wux,t+λux,tp-2ux,t, x,t∈S×0,∞, ux,t=0, x,t∈∂S×0,∞, ux,0=u0, depending on the parameters p>1 and λ>0. Besides, we provide several types of the comparison principles to this equation, which play a key role in the proof of the main theorems. In addition, we finally give some numerical examples which exploit the main results.

  15. Decay estimate of viscosity solutions of nonlinear parabolic PDEs and applications

    Directory of Open Access Journals (Sweden)

    Silvana Marchi

    2014-05-01

    Full Text Available The aim of this paper is to establish a decay estimate for viscosity solutions of nonlinear PDEs. As an application we prove existence and uniqueness for time almost periodic viscosity solutions.

  16. THE CAUCHY PROBLEM FOR A CLASS OF DOUBLY DEGENERATE NONLINEAR PARABOLIC EQUATION

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    This article studies the Cauchy problem for a class of doubly nonlinear deauthor considers its regularized problem and establishes some estimates. On the basis of the estimates, the existence and uniqueness of the generalized solutions in BV space are proved.

  17. A Bivariate Chebyshev Spectral Collocation Quasilinearization Method for Nonlinear Evolution Parabolic Equations

    Directory of Open Access Journals (Sweden)

    S. S. Motsa

    2014-01-01

    Full Text Available This paper presents a new method for solving higher order nonlinear evolution partial differential equations (NPDEs. The method combines quasilinearisation, the Chebyshev spectral collocation method, and bivariate Lagrange interpolation. In this paper, we use the method to solve several nonlinear evolution equations, such as the modified KdV-Burgers equation, highly nonlinear modified KdV equation, Fisher's equation, Burgers-Fisher equation, Burgers-Huxley equation, and the Fitzhugh-Nagumo equation. The results are compared with known exact analytical solutions from literature to confirm accuracy, convergence, and effectiveness of the method. There is congruence between the numerical results and the exact solutions to a high order of accuracy. Tables were generated to present the order of accuracy of the method; convergence graphs to verify convergence of the method and error graphs are presented to show the excellent agreement between the results from this study and the known results from literature.

  18. A bivariate Chebyshev spectral collocation quasilinearization method for nonlinear evolution parabolic equations.

    Science.gov (United States)

    Motsa, S S; Magagula, V M; Sibanda, P

    2014-01-01

    This paper presents a new method for solving higher order nonlinear evolution partial differential equations (NPDEs). The method combines quasilinearisation, the Chebyshev spectral collocation method, and bivariate Lagrange interpolation. In this paper, we use the method to solve several nonlinear evolution equations, such as the modified KdV-Burgers equation, highly nonlinear modified KdV equation, Fisher's equation, Burgers-Fisher equation, Burgers-Huxley equation, and the Fitzhugh-Nagumo equation. The results are compared with known exact analytical solutions from literature to confirm accuracy, convergence, and effectiveness of the method. There is congruence between the numerical results and the exact solutions to a high order of accuracy. Tables were generated to present the order of accuracy of the method; convergence graphs to verify convergence of the method and error graphs are presented to show the excellent agreement between the results from this study and the known results from literature.

  19. Self-similar parabolic plasmonic beams.

    Science.gov (United States)

    Davoyan, Arthur R; Turitsyn, Sergei K; Kivshar, Yuri S

    2013-02-15

    We demonstrate that an interplay between diffraction and defocusing nonlinearity can support stable self-similar plasmonic waves with a parabolic profile. Simplicity of a parabolic shape combined with the corresponding parabolic spatial phase distribution creates opportunities for controllable manipulation of plasmons through a combined action of diffraction and nonlinearity.

  20. Massively parallel-in-space-time, adaptive finite element framework for non-linear parabolic equations

    CERN Document Server

    Dyja, Robert; van der Zee, Kristoffer G

    2016-01-01

    We present an adaptive methodology for the solution of (linear and) non-linear time dependent problems that is especially tailored for massively parallel computations. The basic concept is to solve for large blocks of space-time unknowns instead of marching sequentially in time. The methodology is a combination of a computationally efficient implementation of a parallel-in-space-time finite element solver coupled with a posteriori space-time error estimates and a parallel mesh generator. This methodology enables, in principle, simultaneous adaptivity in both space and time (within the block) domains. We explore this basic concept in the context of a variety of time-steppers including $\\Theta$-schemes and Backward Differentiate Formulas. We specifically illustrate this framework with applications involving time dependent linear, quasi-linear and semi-linear diffusion equations. We focus on investigating how the coupled space-time refinement indicators for this class of problems affect spatial adaptivity. Final...

  1. Nonlinear optical rectification and second-harmonic generation in a semi-parabolic quantum well under intense laser field: Effects of electric and magnetic fields

    Science.gov (United States)

    Ungan, F.; Martínez-Orozco, J. C.; Restrepo, R. L.; Mora-Ramos, M. E.; Kasapoglu, E.; Duque, C. A.

    2015-05-01

    The effects of electric and magnetic fields on the nonlinear optical rectification and second harmonic generation coefficients related with intersubband transitions in a semi-parabolic quantum well under intense laser field are theoretically studied. The energy levels and corresponding wave functions are obtained by solving the conduction band Schrödinger-like equation in the parabolic approximation and the envelope function approach. Numerical calculations are presented for a typical GaAs/Ga1-xAlxAs quantum well. The results show that both the non-resonant intense laser field and the static external fields have significant influences on the magnitude and resonant peak energy positions of the coefficients under study.

  2. Sundance: High-Level Software for PDE-Constrained Optimization

    Directory of Open Access Journals (Sweden)

    Kevin Long

    2012-01-01

    Full Text Available Sundance is a package in the Trilinos suite designed to provide high-level components for the development of high-performance PDE simulators with built-in capabilities for PDE-constrained optimization. We review the implications of PDE-constrained optimization on simulator design requirements, then survey the architecture of the Sundance problem specification components. These components allow immediate extension of a forward simulator for use in an optimization context. We show examples of the use of these components to develop full-space and reduced-space codes for linear and nonlinear PDE-constrained inverse problems.

  3. Parabolic equations and Feynman_Kac formula on general bounded domains

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Gongqing

    2001-01-01

    [1]Berestycki, H., Nirenberg, L., Varadhan, S. V. R., The principal eigenvalue and maximum principle for second order elliptic operators in general domains, Comm. Pure and Appl. Math., 1994, 47: 47.[2]Chen, Y. Z., Alexandrov's maximum principle and Bony's maximum principle for parabolic equations, Acta Mathematica Applicae Sinica, 1985, 2: 309.[3]Dong, G. C., Nonlinear Second Order Partial Differential Equations, AMS Translations, Providence: AMS, 1991.[4]Krylov, N. V., Nonlinear Elliptic and Parabolic Equations of Second Order, Mathematics and Its Applications, Dordrecht: D. Reidel Publication Company, 1987.[5]Tso, K. S., On the Alexandrov_Bakel'man type maximum principle for second order parabolic equations, Comm. PDE, 1985, 10: 543.[6]Miller, K., Barriers on cones for uniformly elliptic operators, Ann. Mat. Pura e Appl., 1967, 76: 93.[7]Strook, D., Varadhan, S. V. R., Multidimensional Diffusion Process, New York, Berlin: Springer_Verlag, 1979.[8]Pinsky, R. G., Positive Harmonic Functions and Diffusions, Cambridge: Cambridge University Press, 1995.[9]Friedman, A., Partial Differential Equations of Parabolic Type, Englewood Cliffs: Prentice_Hall Inc., 1964.

  4. Uniqueness of a very singular solution to nonlinear degenerate parabolic equations with absorption for Dirichlet boundary condition

    Directory of Open Access Journals (Sweden)

    Nguyen Anh Dao

    2016-11-01

    Full Text Available We prove the existence and uniqueness of singular solutions (fundamental solution, very singular solution, and large solution of quasilinear parabolic equations with absorption for Dirichlet boundary condition. We also show the short time behavior of singular solutions as t tends to 0.

  5. High Energy Laser Beam Propagation in the Atmosphere: The Integral Invariants of the Nonlinear Parabolic Equation and the Method of Moments

    Science.gov (United States)

    Manning, Robert M.

    2012-01-01

    The method of moments is used to define and derive expressions for laser beam deflection and beam radius broadening for high-energy propagation through the Earth s atmosphere. These expressions are augmented with the integral invariants of the corresponding nonlinear parabolic equation that describes the electric field of high-energy laser beam to propagation to yield universal equations for the aforementioned quantities; the beam deflection is a linear function of the propagation distance whereas the beam broadening is a quadratic function of distance. The coefficients of these expressions are then derived from a thin screen approximation solution of the nonlinear parabolic equation to give corresponding analytical expressions for a target located outside the Earth s atmospheric layer. These equations, which are graphically presented for a host of propagation scenarios, as well as the thin screen model, are easily amenable to the phase expansions of the wave front for the specification and design of adaptive optics algorithms to correct for the inherent phase aberrations. This work finds application in, for example, the analysis of beamed energy propulsion for space-based vehicles.

  6. Optimization with PDE constraints

    CERN Document Server

    Pinnau, Rene

    2008-01-01

    Presents an introduction of pde constrained optimization. This book provides a precise functional analytic treatment via optimality conditions and a non-smooth algorithmical framework. It also presents structure-exploiting discrete concepts and large scale, practically relevant applications.

  7. 一个具有非线性边界条件的抛物系统整体存在性和爆破%GLOBAL EXISTENCE AND BLOW UP FOR A PARABOLIC SYSTEM WITH NONLINEAR BOUNDARY CONDITION

    Institute of Scientific and Technical Information of China (English)

    徐龙封

    2004-01-01

    In this paper the nonnegative classical solutions of a parabolic system with nonlinear boundary conditions are discussed. The existence and uniqueness of a nonnegative classical solution are proved. And some sufficient conditions to ensure the global existence and nonexistence of nonnegative classical solution to this problem are given.

  8. 非线性抛物型方程有限元法数值积分的有效性%THE EFFECT OF NUMERICAL INTEGRATION IN FINITE ELEMENT METHODS FOR NONLINEAR PARABOLIC EQUATIONS

    Institute of Scientific and Technical Information of China (English)

    哲曼

    2001-01-01

    The effect of numerical integration in finite element methods applied to a class of nonlinear parabolic equations is considered and some sufficient conditions on the quadrature scheme to ensure that the order of convergence is unaltered in the presence of numerical integration are given. Optimal L2 and H1 estimates for the error and its time derivative are established.

  9. Finite Volume Element Predictor-corrector Method for a Class of Nonlinear Parabolic Systems%一类非线性抛物型方程组的有限体积元预估-校正方法

    Institute of Scientific and Technical Information of China (English)

    高夫征

    2005-01-01

    A finite volume element predictor-correetor method for a class of nonlinear parabolic system of equations is presented and analyzed. Suboptimal L2 error estimate for the finite volume element predictor-corrector method is derived. A numerical experiment shows that the numerical results are consistent with theoretical analysis.

  10. Intensity noise reduction of a high-power nonlinear femtosecond fiber amplifier based on spectral-breathing self-similar parabolic pulse evolution

    Science.gov (United States)

    Wang, Sijia; Liu, Bowen; Song, Youjian; Hu, Minglie

    2016-04-01

    We report on a simple passive scheme to reduce the intensity noise of high-power nonlinear fiber amplifiers by use of the spectral-breathing parabolic evolution of the pulse amplification with an optimized negative initial chirp. In this way, the influences of amplified spontaneous emission (ASE) on the amplifier intensity noise can be efficiently suppressed, owing to the lower overall pulse chirp, shorter spectral broadening distance, as well as the asymptotic attractive nature of self-similar pulse amplification. Systematic characterizations of the relative intensity noise (RIN) of a free-running nonlinear Yb-doped fiber amplifier are performed over a series of initial pulse parameters. Experiments show that the measured amplifier RIN increases respect to the decreased input pulse energy, due to the increased amount of ASE noise. For pulse amplification with a proper negative initial chirp, the increase of RIN is found to be smaller than with a positive initial chirp, confirming the ASE noise tolerance of the proposed spectral-breathing parabolic amplification scheme. At the maximum output average power of 27W (25-dB amplification gain), the incorporation of an optimum negative initial chirp (-0.84 chirp parameter) leads to a considerable amplifier root-mean-square (rms) RIN reduction of ~20.5% (integrated from 10 Hz to 10 MHz Fourier frequency). The minimum amplifier rms RIN of 0.025% (integrated from 1 kHz to 5 MHz Fourier frequency) is obtained along with the transform-limited compressed pulse duration of 55fs. To our knowledge, the demonstrated intensity noise performance is the lowest RIN level measured from highpower free-running femtosecond fiber amplifiers.

  11. PDE-SVD Based Audio Denoising

    OpenAIRE

    Baravdish, George; Evangelista, Gianpaolo; Svensson, Olof; Sofya, Faten

    2012-01-01

    In this paper we present a new method for denoising audio signals. The method is based on the Singular Value Decomposition (SVD) of the frame matrix representing the signal inthe Overlap Add decomposition. Denoising is performed by modifying both the singular values, using a tapering model, and the singular vectors of the representation, using a nonlinear PDE method. The performance of the method is evaluated and compared with denoising obtained by filtering.

  12. Null controllability for a parabolic-elliptic coupled system

    CERN Document Server

    Fernández-Cara, E; de Menezes, S B

    2012-01-01

    In this paper, we prove the null controllability of some parabolic-elliptic systems. The control is distributed, locally supported in space and appears only in one PDE. The arguments rely on fixed-point reformulation and suitable Carleman estimates for the solutions to the adjoint system. Under appropriate assumptions, we also prove that the solution can be obtained as the asymptotic limit of some similar parabolic systems.

  13. Medical X-Ray Image Enhancement Based on Kramer's PDE Model

    Institute of Scientific and Technical Information of China (English)

    Yan-Fei Zhao; Qing-Wei Gao; De-Xiang Zhang; Yi-Xiang Lu

    2007-01-01

    The purpose of this study is to present an application of a novel enhancement technique for enhancing medical images generated from X-rays. The method presented in this study is based on a nonlinear partial differential equation (PDE) model, Kramer's PDE model. The usefulness of this method is investigated by experimental results. We apply this method to a medical X-ray image. For comparison, the X-ray image is also processed using classic Perona-Malik PDE model and Catte PDE model. Although the Perona-Malik model and Catte PDE model could also enhance the image, the quality of the enhanced images is considerably inferior compared with the enhanced image using Kramer's PDE model. The study suggests that the Kramer's PDE model is capable of enhancing medical X-ray images, which will make the X-ray images more reliable.

  14. Stability test for a parabolic partial differential equation

    NARCIS (Netherlands)

    Vajta, Miklos

    2001-01-01

    The paper describes a stability test applied to coupled parabolic partial differential equations. The PDE's describe the temperature distribution of composite structures with linear inner heat sources. The distributed transfer functions are developed based on the transmission matrix of each layer.

  15. Nyquist stability test for a parabolic partial differential equation

    NARCIS (Netherlands)

    Vajta, Miklos; Hamza, M.H.

    2000-01-01

    The paper describes a Nyquist stability test applied to a parabolic partial differential equation. The PDE describes the temperature distribution of composite structures with linear inner heat source. The distributed transfer functions have been developed by the transmission matrix method. To

  16. Iterative methods for distributed parameter estimation in parabolic PDE

    Energy Technology Data Exchange (ETDEWEB)

    Vogel, C.R. [Montana State Univ., Bozeman, MT (United States); Wade, J.G. [Bowling Green State Univ., OH (United States)

    1994-12-31

    The goal of the work presented is the development of effective iterative techniques for large-scale inverse or parameter estimation problems. In this extended abstract, a detailed description of the mathematical framework in which the authors view these problem is presented, followed by an outline of the ideas and algorithms developed. Distributed parameter estimation problems often arise in mathematical modeling with partial differential equations. They can be viewed as inverse problems; the `forward problem` is that of using the fully specified model to predict the behavior of the system. The inverse or parameter estimation problem is: given the form of the model and some observed data from the system being modeled, determine the unknown parameters of the model. These problems are of great practical and mathematical interest, and the development of efficient computational algorithms is an active area of study.

  17. Parabolic tapers for overmoded waveguides

    Science.gov (United States)

    Doane, J.L.

    1983-11-25

    A waveguide taper with a parabolic profile, in which the distance along the taper axis varies as the square of the tapered dimension, provides less mode conversion than equal length linear tapers and is easier to fabricate than other non-linear tapers.

  18. Residual Minimizing Model Reduction for Parameterized Nonlinear Dynamical Systems

    CERN Document Server

    Constantine, Paul G

    2010-01-01

    We present a method for approximating the solution of a parameterized, nonlinear dynamical (or static) system using an affine combination of solutions computed at other points in the input parameter space. The coefficients of the affine combination are computed with a nonlinear least squares procedure that minimizes the residual of the dynamical system. The approximation properties of this residual minimizing scheme are comparable to existing reduced basis and POD-Galerkin model reduction methods, but its implementation requires only independent evaluations of the nonlinear forcing function. We prove some interesting characteristics of the scheme including uniqueness and an interpolatory property, and we present heuristics for mitigating the effects of the ill-conditioning and reducing the overall cost of the method. We apply the method to representative numerical examples from kinetics - a three state system with one parameter controlling the stiffness - and groundwater modeling - a nonlinear parabolic PDE w...

  19. Flux form Semi-Lagrangian methods for parabolic problems

    CERN Document Server

    Bonaventura, Luca

    2015-01-01

    A semi-Lagrangian method for parabolic problems is proposed, that extends previous work by the authors to achieve a fully conservative, flux-form discretization of linear and nonlinear diffusion equations. A basic consistency and convergence analysis are proposed. Numerical examples validate the proposed method and display its potential for consistent semi-Lagrangian discretization of advection--diffusion and nonlinear parabolic problems.

  20. 一类具有非线性内部源和边界流的双重退化抛物型方程%Doubly Degenerate Parabolic Equation with Nonlinear Inner and Boundary Sources

    Institute of Scientific and Technical Information of China (English)

    姜朝欣

    2007-01-01

    This paper deals with blow-up criterion for a doubly degenerate parabolic equation of the form (un)t = (|ux|m-1ux)x + up in (0, 1) × (0, T) subject to nonlinear boundary source (|ux|m-1ux)(1,t) = uq(1,t), (|ux|m-1ux)(0,t) = 0, and positive initial data u(x,0) = uo(x), where the parameters m, n, p, q > 0.It is proved that the problem possesses global solutions if and only if p ≤ n and q≤min{n, m(n+1)/ m+1}.

  1. International Workshop on Elliptic and Parabolic Equations

    CERN Document Server

    Schrohe, Elmar; Seiler, Jörg; Walker, Christoph

    2015-01-01

    This volume covers the latest research on elliptic and parabolic equations and originates from the international Workshop on Elliptic and Parabolic Equations, held September 10-12, 2013 at the Leibniz Universität Hannover. It represents a collection of refereed research papers and survey articles written by eminent scientist on advances in different fields of elliptic and parabolic partial differential equations, including singular Riemannian manifolds, spectral analysis on manifolds, nonlinear dispersive equations, Brownian motion and kernel estimates, Euler equations, porous medium type equations, pseudodifferential calculus, free boundary problems, and bifurcation analysis.

  2. Parabolic-like maps

    CERN Document Server

    Lomonaco, Luciana Luna Anna

    2011-01-01

    In this paper we introduce the notion of parabolic-like mapping, which is an object similar to a polynomial-like mapping, but with a parabolic external class, i.e. an external map with a parabolic fixed point. We prove a straightening theorem for parabolic-like maps, which states that any parabolic-like map of degree 2 is hybrid conjugate to a member of the family Per_1(1), and this member is unique (up to holomorphic conjugacy) if the filled Julia set of the parabolic-like map is connected.

  3. Parabolic scaling beams.

    Science.gov (United States)

    Gao, Nan; Xie, Changqing

    2014-06-15

    We generalize the concept of diffraction free beams to parabolic scaling beams (PSBs), whose normalized intensity scales parabolically during propagation. These beams are nondiffracting in the circular parabolic coordinate systems, and all the diffraction free beams of Durnin's type have counterparts as PSBs. Parabolic scaling Bessel beams with Gaussian apodization are investigated in detail, their nonparaxial extrapolations are derived, and experimental results agree well with theoretical predictions.

  4. Weak and strong minima : from calculus of variation toward PDE optimization

    OpenAIRE

    2013-01-01

    This note summarizes some recent advances on the theory of optimality conditions for PDE optimization. We focus our attention on the concept of strong minima for optimal control problems governed by semi-linear elliptic and parabolic equations. Whereas in the field of calculus of variations this notion has been deeply investigated, the study of strong solutions for optimal control problems of partial differential equations (PDEs) has been addressed recently. We first revisit some well-known r...

  5. Controllable parabolic-cylinder optical rogue wave.

    Science.gov (United States)

    Zhong, Wei-Ping; Chen, Lang; Belić, Milivoj; Petrović, Nikola

    2014-10-01

    We demonstrate controllable parabolic-cylinder optical rogue waves in certain inhomogeneous media. An analytical rogue wave solution of the generalized nonlinear Schrödinger equation with spatially modulated coefficients and an external potential in the form of modulated quadratic potential is obtained by the similarity transformation. Numerical simulations are performed for comparison with the analytical solutions and to confirm the stability of the rogue wave solution obtained. These optical rogue waves are built by the products of parabolic-cylinder functions and the basic rogue wave solution of the standard nonlinear Schrödinger equation. Such rogue waves may appear in different forms, as the hump and paw profiles.

  6. A NONLINEAR TRANSFORMATION AND A BOUNDARY-INITIAL VALUE PROBLEM FOR ACLASS OF NONLINEAR CONVECTION-DIFFUSION EQUATIONS

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    With the aid of a nonlinear transformation, a class of nonlinear convectiondiffusion PDE in one space dimension is converted into a linear one, the unique solution of a nonlinear boundary-initial value problem for the nonlinear PDE can be exactly expressed by the nonlinear transformation, and several illustrative examples are given

  7. The pde2path add-on toolbox p2pOC for solving infinite time-horizon spatially distributed optimal control problems - Quickstart Guide -

    OpenAIRE

    Uecker, Hannes

    2015-01-01

    p2pOC is an add-on toolbox to the Matlab package pde2path. It is aimed at the numerical solution of optimal control (OC) problems with an infinite time horizon for parabolic systems of PDE over 1D or 2D spatial domains. The basic idea is to treat the OC problem via the associated canonical system in two steps. First we use pde2path to find branches of stationary solutions of the canonical system, also called canonical steady states (CSS). In a second step we use the results and the spatial di...

  8. Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development.

    Science.gov (United States)

    Kayık, Gülru; Tüzün, Nurcan Ş; Durdagi, Serdar

    2017-12-01

    The essential biological function of phosphodiesterase (PDE) type enzymes is to regulate the cytoplasmic levels of intracellular second messengers, 3',5'-cyclic guanosine monophosphate (cGMP) and/or 3',5'-cyclic adenosine monophosphate (cAMP). PDE targets have 11 isoenzymes. Of these enzymes, PDE5 has attracted a special attention over the years after its recognition as being the target enzyme in treating erectile dysfunction. Due to the amino acid sequence and the secondary structural similarity of PDE6 and PDE11 with the catalytic domain of PDE5, first-generation PDE5 inhibitors (i.e. sildenafil and vardenafil) are also competitive inhibitors of PDE6 and PDE11. Since the major challenge of designing novel PDE5 inhibitors is to decrease their cross-reactivity with PDE6 and PDE11, in this study, we attempt to identify potent tadalafil-like PDE5 inhibitors that have PDE5/PDE6 and PDE5/PDE11 selectivity. For this aim, the similarity-based virtual screening protocol is applied for the "clean drug-like subset of ZINC database" that contains more than 20 million small compounds. Moreover, molecular dynamics (MD) simulations of selected hits complexed with PDE5 and off-targets were performed in order to get insights for structural and dynamical behaviors of the selected molecules as selective PDE5 inhibitors. Since tadalafil blocks hERG1 K channels in concentration dependent manner, the cardiotoxicity prediction of the hit molecules was also tested. Results of this study can be useful for designing of novel, safe and selective PDE5 inhibitors.

  9. Parabolic Equations in Musielak-Orlicz-Sobolev Spaces

    Directory of Open Access Journals (Sweden)

    M.L. Ahmed Oubeid

    2013-11-01

    Full Text Available We prove in this paper the existence of solutions of nonlinear parabolic problems in Musielak-Orlicz-Sobolev spaces. An approximation and a trace results in inhomogeneous Musielak-Orlicz-Sobolev spaces have also been provided.

  10. Femtosecond parabolic pulse shaping in normally dispersive optical fibers.

    Science.gov (United States)

    Sukhoivanov, Igor A; Iakushev, Sergii O; Shulika, Oleksiy V; Díez, Antonio; Andrés, Miguel

    2013-07-29

    Formation of parabolic pulses at femtosecond time scale by means of passive nonlinear reshaping in normally dispersive optical fibers is analyzed. Two approaches are examined and compared: the parabolic waveform formation in transient propagation regime and parabolic waveform formation in the steady-state propagation regime. It is found that both approaches could produce parabolic pulses as short as few hundred femtoseconds applying commercially available fibers, specially designed all-normal dispersion photonic crystal fiber and modern femtosecond lasers for pumping. The ranges of parameters providing parabolic pulse formation at the femtosecond time scale are found depending on the initial pulse duration, chirp and energy. Applicability of different fibers for femtosecond pulse shaping is analyzed. Recommendation for shortest parabolic pulse formation is made based on the analysis presented.

  11. Parabolic trough systems; Parabolrinnensysteme

    Energy Technology Data Exchange (ETDEWEB)

    Geyer, M. [Flabeg Solar International GmbH (Germany); Lerchenmueller, H.; Wittwer, V. [Fraunhofer ISE, Freiburg (Germany); Haeberle, A. [PSE GmbH (Germany); Luepfert, E.; Hennecke, K. [DLR, Koeln (Germany); Schiel, W. [SBP (Germany); Brakmann, G. [Fichtner Solar GmbH (Germany)

    2002-07-01

    The technology of parabolic trough power plants is presented: History, comparative assessment of different types of parabolic trough collectors, fresnel collectors, solar tracking systems, thermal efficiency, further research, performance of the SEGS parabolic trough power station in California. [German] Die Technik von Parabolrinnen-Kraftwerken wird vorgestellt: Entwicklungsgeschichte, Vergleich verschiedener Parabolrinnenkollektoren, fresnel kollektoren, Nachfuehrsysteme, thermischer Wirkungsgrad, weiterer Forschungsbedarf und Betriebserfahrung mit dem SEGS Parabolrinnenkraftwerk in Kalifornien. (uke)

  12. Flux form Semi-Lagrangian methods for parabolic problems

    Directory of Open Access Journals (Sweden)

    Bonaventura Luca

    2016-09-01

    Full Text Available A semi-Lagrangian method for parabolic problems is proposed, that extends previous work by the authors to achieve a fully conservative, flux-form discretization of linear and nonlinear diffusion equations. A basic consistency and stability analysis is proposed. Numerical examples validate the proposed method and display its potential for consistent semi-Lagrangian discretization of advection diffusion and nonlinear parabolic problems.

  13. Mineral resource analysis by parabolic fractals

    Institute of Scientific and Technical Information of China (English)

    XIE Shu-yun; YANG Yong-guo; BAO Zheng-yu; KE Xian-zhong; LIU Xiao-long

    2009-01-01

    Elemental concentration distributions in space have been analyzed using different approaches. These analyses are of great significance for the quantitative characterization of various kinds of distribution patterns. Fractal and multi-fiactal methods have been extensively applied to this topic. Traditionally, approximately linear-fractal laws have been regarded as useful tools for characterizing the self-similarities of element concentrations. But, in nature, it is not always easy to fred perfect linear fractal laws. In this paper the parabolic fractal model is used. First a two dimensional multiplicative multi-fractal cascade model is used to study the concentration patterns. The results show the parabolic fractal (PF) properties of the concentrations and the validity of non-linear fractal analysis. By dividing the studied area into four sub-areas it was possible to show that each part follows a non-linear para-bolic fractal law and that the dispersion within each part varies. The ratio of the polynomial coefficients of the fitted parabolic curves can reflect, to some degree, the relative concentration and dispersal distribution patterns. This can provide new insight into the ore-forming potential in space. The parabolic fractal evaluations of ore-forming potential for the four subareas are in good agreement with field investigation work and geochemical mapping results based on analysis of the original data.

  14. A Finite Volume Backward Euler Difference Method for Nonlinear Parabolic Integral-differential Equation%非线性抛物型积分-微分方程的向后Euler差分有限体积元方法

    Institute of Scientific and Technical Information of China (English)

    王波; 王强

    2009-01-01

    The Finite volume backward Euler difference method is established to discuss two-dimensional parabolic integro-differential equations.These results are new for finite volume element methods for parabolic integro-differential equations.

  15. Parabolic Dish Stirling Module

    Science.gov (United States)

    Washom, B.

    1984-01-01

    The design, manufacture, and assembly of a commercially designed parabolic dish Stirling 25 kWe module is examined. The cost, expected performance, design uniquenesses, and future commercial potential of this module, which is regarded as the most technically advanced in the parabolic dish industry is discussed.

  16. Finite-dimensional constrained fuzzy control for a class of nonlinear distributed process systems.

    Science.gov (United States)

    Wu, Huai-Ning; Li, Han-Xiong

    2007-10-01

    This correspondence studies the problem of finite-dimensional constrained fuzzy control for a class of systems described by nonlinear parabolic partial differential equations (PDEs). Initially, Galerkin's method is applied to the PDE system to derive a nonlinear ordinary differential equation (ODE) system that accurately describes the dynamics of the dominant (slow) modes of the PDE system. Subsequently, a systematic modeling procedure is given to construct exactly a Takagi-Sugeno (T-S) fuzzy model for the finite-dimensional ODE system under state constraints. Then, based on the T-S fuzzy model, a sufficient condition for the existence of a stabilizing fuzzy controller is derived, which guarantees that the state constraints are satisfied and provides an upper bound on the quadratic performance function for the finite-dimensional slow system. The resulting fuzzy controllers can also guarantee the exponential stability of the closed-loop PDE system. Moreover, a local optimization algorithm based on the linear matrix inequalities is proposed to compute the feedback gain matrices of a suboptimal fuzzy controller in the sense of minimizing the quadratic performance bound. Finally, the proposed design method is applied to the control of the temperature profile of a catalytic rod.

  17. Preconditioned fully implicit PDE solvers for monument conservation

    CERN Document Server

    Semplice, Matteo

    2010-01-01

    Mathematical models for the description, in a quantitative way, of the damages induced on the monuments by the action of specific pollutants are often systems of nonlinear, possibly degenerate, parabolic equations. Although some the asymptotic properties of the solutions are known, for a short window of time, one needs a numerical approximation scheme in order to have a quantitative forecast at any time of interest. In this paper a fully implicit numerical method is proposed, analyzed and numerically tested for parabolic equations of porous media type and on a systems of two PDEs that models the sulfation of marble in monuments. Due to the nonlinear nature of the underlying mathematical model, the use of a fixed point scheme is required and every step implies the solution of large, locally structured, linear systems. A special effort is devoted to the spectral analysis of the relevant matrices and to the design of appropriate iterative or multi-iterative solvers, with special attention to preconditioned Krylo...

  18. Manufacturing parabolic mirrors

    CERN Multimedia

    CERN PhotoLab

    1975-01-01

    The photo shows the construction of a vertical centrifuge mounted on an air cushion, with a precision of 1/10000 during rotation, used for the manufacture of very high=precision parabolic mirrors. (See Annual Report 1974.)

  19. Oscillation of Solutions of Nonlinear Neutral Parabolic Differential Equations%非线性中立型抛物微分方程解的振动性

    Institute of Scientific and Technical Information of China (English)

    刘克英; 徐少贤; 刘安平

    2005-01-01

    This paper deals with the oscillatory properties of a class of nonlinear neutralparabolic partial differential equations with several delays. Sufficient criteria for the equa-tion to be oscillatory are obtained by making use of some results of first-order functionaldifferential inequalities. These results fully reveal the essential difference between this typeand that without delays.

  20. Trends in PDE constrained optimization

    CERN Document Server

    Benner, Peter; Engell, Sebastian; Griewank, Andreas; Harbrecht, Helmut; Hinze, Michael; Rannacher, Rolf; Ulbrich, Stefan

    2014-01-01

    Optimization problems subject to constraints governed by partial differential equations (PDEs) are among the most challenging problems in the context of industrial, economical and medical applications. Almost the entire range of problems in this field of research was studied and further explored as part of the Deutsche Forschungsgemeinschaft (DFG) priority program 1253 on “Optimization with Partial Differential Equations” from 2006 to 2013. The investigations were motivated by the fascinating potential applications and challenging mathematical problems that arise in the field of PDE constrained optimization. New analytic and algorithmic paradigms have been developed, implemented and validated in the context of real-world applications. In this special volume, contributions from more than fifteen German universities combine the results of this interdisciplinary program with a focus on applied mathematics.   The book is divided into five sections on “Constrained Optimization, Identification and Control”...

  1. PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system

    DEFF Research Database (Denmark)

    Kruse, Lars S; Møller, Morten; Tibaek, Maiken

    2009-01-01

    Activation of the trigeminovascular pain signalling system, including cerebral arteries, meninges, trigeminal ganglion, and brain stem, is involved in migraine. Furthermore, stimulation of cyclic nucleotide (cAMP and cGMP) production as well as inhibition of phosphodiesterases (PDEs) induces head......, the expression of PDE9A, PDE10A, and PDE11A in the trigeminovascular system. The functional implications are yet unknown, but their localisation indicates that they may have a role in the pain pathway of migraine as well as trigeminal neuralgia and trigeminal autonomic cephalalgias....

  2. On some perturbation techniques for quasi-linear parabolic equations

    Directory of Open Access Journals (Sweden)

    Igor Malyshev

    1990-01-01

    Full Text Available We study a nonhomogeneous quasi-linear parabolic equation and introduce a method that allows us to find the solution of a nonlinear boundary value problem in “explicit” form. This task is accomplished by perturbing the original equation with a source function, which is then found as a solution of some nonlinear operator equation.

  3. A short proof of increased parabolic regularity

    Directory of Open Access Journals (Sweden)

    Stephen Pankavich

    2015-08-01

    Full Text Available We present a short proof of the increased regularity obtained by solutions to uniformly parabolic partial differential equations. Though this setting is fairly introductory, our new method of proof, which uses a priori estimates and an inductive method, can be extended to prove analogous results for problems with time-dependent coefficients, advection-diffusion or reaction diffusion equations, and nonlinear PDEs even when other tools, such as semigroup methods or the use of explicit fundamental solutions, are unavailable.

  4. INVERSE COEFFICIENT PROBLEMS FOR PARABOLIC HEMIVARIATIONAL INEQUALITIES

    Institute of Scientific and Technical Information of China (English)

    Liu Zhenhai; I.Szántó

    2011-01-01

    This paper is devoted to the class of inverse problems for a nonlinear parabolic hemivariational inequality.The unknown coefficient of the operator depends on the gradient of the solution and belongs to a set of admissible coefficients.It is proved that the convergence of solutions for the corresponding direct problems continuously depends on the coefficient convergence.Based on this result the existence of a quasisolution of the inverse problem is obtained.

  5. A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition.

    Directory of Open Access Journals (Sweden)

    Didem Demirbas

    Full Text Available A cell-based high-throughput screen (HTS was developed to detect phosphodiesterase 8 (PDE8 and PDE4/8 combination inhibitors. By replacing the Schizosaccharomyces pombe PDE gene with the murine PDE8A1 gene in strains lacking adenylyl cyclase, we generated strains whose protein kinase A (PKA-stimulated growth in 5-fluoro orotic acid (5FOA medium reflects PDE8 activity. From our previously-identified PDE4 and PDE7 inhibitors, we identified a PDE4/8 inhibitor that allowed us to optimize screening conditions. Of 222,711 compounds screened, ∼0.2% displayed composite Z scores of >20. Additional yeast-based assays using the most effective 367 compounds identified 30 candidates for further characterization. Among these, compound BC8-15 displayed the lowest IC₅₀ value for both PDE4 and PDE8 inhibition in in vitro enzyme assays. This compound also displays significant activity against PDE10A and PDE11A. BC8-15 elevates steroidogenesis in mouse Leydig cells as a single pharmacological agent. Assays using BC8-15 and two structural derivatives support a model in which PDE8 is a primary regulator of testosterone production by Leydig cells, with an additional role for PDE4 in this process. BC8-15, BC8-15A, and BC8-15C, which are commercially available compounds, display distinct patterns of activity against PDE4, PDE8, PDE10A, and PDE11A, representing a chemical toolkit that could be used to examine the biological roles of these enzymes in cell culture systems.

  6. Preliminary Determination of Epicenters (PDE) Bulletin

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The NEIC global earthquake bulletin is called the Preliminary Determination of Epicenters or PDE, and is one of many discrete products in the ANSS Comprehensive...

  7. Parabolic Strip Telescope

    CERN Document Server

    Chadzitaskos, Goce

    2013-01-01

    We present a proposal of a new type of telescopes using a rotating parabolic strip as the primary mirror. It is the most principal modification of the design of telescopes from the times of Galileo and Newton. In order to demonstrate the basic idea, the image of an artificial constellation observed by this kind of telescope was reconstructed using the techniques described in this article. As a working model of this new telescope, we have used an assembly of the primary mirror---a strip of acrylic glass parabolic mirror 40 cm long and 10 cm wid shaped as a parabolic cylinder of focal length 1 m---and an artificial constellation, a set of 5 apertures in a distance of 5 m illuminated from behind. In order to reconstruct the image, we made a series of snaps, each after a rotation of the constellation by 15 degrees. Using Matlab we reconstructed the image of the artificial constellation.

  8. In-plane elastic stability of fixed parabolic shallow arches

    Institute of Scientific and Technical Information of China (English)

    CAI JianGuo; FENG Jian; CHEN Yao; HUANG LiFeng

    2009-01-01

    The nonlinear behavior of fixed parabolic shallow arches subjected to a vertical uniform load is inves-tigated to evaluate the in-plane buckling load. The virtual work principle method is used to establish the non-linear equilibrium and buckling equations. Analytical solutions for the non-linear in-plane sym-metric snap-through and antisymmetric bifurcation buckling loads are obtained. Based on the least square method, an approximation for the symmetric buckling load of fixed parabolic arch is proposedto simplify the solution process. And the relation between modified slenderness and buckling modes are discussed. Comparisons with the results of finite element analysis demonstrate that the solutions are accurate. A cable-arch structure is presented to improve the in-plane stability of parabolic arches. The comparison of buckling loads between cable-arch systems and arches only show that the effect of cables becomes more evident with the increase of arch's modified slenderness.

  9. In-plane elastic stability of fixed parabolic shallow arches

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The nonlinear behavior of fixed parabolic shallow arches subjected to a vertical uniform load is inves- tigated to evaluate the in-plane buckling load. The virtual work principle method is used to establish the non-linear equilibrium and buckling equations. Analytical solutions for the non-linear in-plane sym- metric snap-through and antisymmetric bifurcation buckling loads are obtained. Based on the least square method, an approximation for the symmetric buckling load of fixed parabolic arch is proposed to simplify the solution process. And the relation between modified slenderness and buckling modes are discussed. Comparisons with the results of finite element analysis demonstrate that the solutions are accurate. A cable-arch structure is presented to improve the in-plane stability of parabolic arches. The comparison of buckling loads between cable-arch systems and arches only show that the effect of cables becomes more evident with the increase of arch’s modified slenderness.

  10. Study on Parabolic Self-Similar Pulse Generation in a Nonlinearity Increasing Fiber%基于非线性渐增原理获得抛物线型自相似脉冲的研究

    Institute of Scientific and Technical Information of China (English)

    李莉苹; 张爱玲

    2011-01-01

    The self-similar evolution of an initial Gaussian pulse propagating in a nonlinearity increasing fiber (NIF) with an exponential nonlinearity profile is studied theoretically and numerically. As well as the dispersion decreasing fiber with normal group velocity dispersion (ND-DDF with a hyperbolic dispersion profile) , the NIF is also equivalent to a fiber amplifier, which can generate a parabolic self-similar pulse with strictly linear chirp. Furthermore, the impacts of two equivalent ways of ND-DDF and NIF on characteristics of the self-similar evolution are studied. The theoretical and simulation results show that: 1) the equivalent gain determines the results of self-similar evolution while the equivalent method determines the process speed; 2) with the same equivalent gain, the initial pulses in ND-DDF and NIF both evolve into the same parabolic self-similar pulse, but the process of NIF is more efficient, needing a shorter fiber length; 3) the relationship of fiber lengths of NIF and ND-DDF is to make the two fibers have the same "effective amplification".%采用理论推导和数值模拟相结合的方法研究了脉冲在指数渐增的非线性渐增光纤(NIF)中的自相似演化.结果表明,与双曲渐减的正色散渐减光纤(ND-DDF)类似,利用指数渐增的NIF也可获得具有严格线性凋啾的抛物线型自相似脉冲.同时深人研究了ND-DDF和NIF两种增益等效方式对自相似演化特性的影响,结果表明:1)等效增益决定了脉冲自相似演化的结果,等效方式决定了脉冲自相似演化进程快慢;2)在具有相等的等效增益条件下,脉冲在指数渐增NIF和双曲渐减ND-DDF中演化为相同的自相似脉冲,但是前者对脉冲的自相似演化更高效,即前者实现自相似演化所需光纤长度更短;3)两种增益等效方式所需光纤长度的关系是使得各自具有相同的光纤"有效放大因子".

  11. 二维非线性抛物型方程参数反演的贝叶斯推理估计%The estimated Bayesian inference of two-dimensional nonlinear parabolic equation parameter inversion

    Institute of Scientific and Technical Information of China (English)

    陈亚文; 邹学文

    2012-01-01

    为了克服观测数据有限以及数据存在一定误差对参数反演结果的影响,提出了一种参数反演的有效算法.根据已知参数的先验分布和已经获得的有误差的监测数据,以贝叶斯推理作为理论基础,获得参数的联合后验概率密度函数,再利用马尔科夫链蒙特卡罗模拟对后验分布进行采样,获得参数的后验边缘概率密度,由此得到了参数的数学期望等有效的统计量.数值模拟结果表明,此算法能够有效地解决二维非线性抛物型方程的参数识别反问题,且具有较高的精度.%In order to overcome the limited observation data with noise, an inversion of the effective parameters algorithm is presented. First, according to the parameters,a priori distribution and the limited observation data with noise, Bayesian inference as a theoretical foundation,parameters of the joint posterior probability density function are obtained. Markov chain Monte Carlo simulation was taken to sample the posterior distribution to get the marginal posterior probability function of the parameters, and the statistical quantities such as the mathematic expectation were calculated. Experimental results show that this algorithm can successfully solve the problem of two-dimensional nonlinear parabolic equation parameter inversion and inversion results have higher accuracy.

  12. Approximate Ad Hoc Parametric Solutions for Nonlinear First-Order PDEs Governing Two-Dimensional Steady Vector Fields

    Directory of Open Access Journals (Sweden)

    M. P. Markakis

    2010-01-01

    Full Text Available Through a suitable ad hoc assumption, a nonlinear PDE governing a three-dimensional weak, irrotational, steady vector field is reduced to a system of two nonlinear ODEs: the first of which corresponds to the two-dimensional case, while the second involves also the third field component. By using several analytical tools as well as linear approximations based on the weakness of the field, the first equation is transformed to an Abel differential equation which is solved parametrically. Thus, we obtain the two components of the field as explicit functions of a parameter. The derived solution is applied to the two-dimensional small perturbation frictionless flow past solid surfaces with either sinusoidal or parabolic geometry, where the plane velocities are evaluated over the body's surface in the case of a subsonic flow.

  13. Parabolic k-ample bundles

    CERN Document Server

    Biswas, Indranil

    2011-01-01

    We construct projectivization of a parabolic vector bundle and a tautological line bundle over it. It is shown that a parabolic vector bundle is ample if and only if the tautological line bundle is ample. This allows us to generalize the notion of a k-ample bundle, introduced by Sommese, to the context of parabolic bundles. A parabolic vector bundle $E_*$ is defined to be k-ample if the tautological line bundle ${\\mathcal O}_{{\\mathbb P}(E_*)}(1)$ is $k$--ample. We establish some properties of parabolic k-ample bundles.

  14. Tumour growth inhibition and anti-angiogenic effects using curcumin correspond to combined PDE2 and PDE4 inhibition.

    Science.gov (United States)

    Abusnina, Abdurazzag; Keravis, Thérèse; Zhou, Qingwei; Justiniano, Hélène; Lobstein, Annelise; Lugnier, Claire

    2015-02-01

    Vascular endothelial growth factor (VEGF) plays a major role in angiogenesis by stimulating endothelial cells. Increase in cyclic AMP (cAMP) level inhibits VEGF-induced endothelial cell proliferation and migration. Cyclic nucleotide phosphodiesterases (PDEs), which specifically hydrolyse cyclic nucleotides, are critical in the regulation of this signal transduction. We have previously reported that PDE2 and PDE4 up-regulations in human umbilical vein endothelial cells (HUVECs) are implicated in VEGF-induced angiogenesis and that inhibition of PDE2 and PDE4 activities prevents the development of the in vitro angiogenesis by increasing cAMP level, as well as the in vivo chicken embryo angiogenesis. We have also shown that polyphenols are able to inhibit PDEs. The curcumin having anti-cancer properties, the present study investigated whether PDE2 and PDE4 inhibitors and curcumin could have similar in vivo anti-tumour properties and whether the anti-angiogenic effects of curcumin are mediated by PDEs. Both PDE2/PDE4 inhibitor association and curcumin significantly inhibited in vivo tumour growth in C57BL/6N mice. In vitro, curcumin inhibited basal and VEGF-stimulated HUVEC proliferation and migration and delayed cell cycle progression at G0/G1, similarly to the combination of selective PDE2 and PDE4 inhibitors. cAMP levels in HUVECs were significantly increased by curcumin, similarly to rolipram (PDE4 inhibitor) and BAY-60-550 (PDE2 inhibitor) association, indicating cAMP-PDE inhibitions. Moreover, curcumin was able to inhibit VEGF-induced cAMP-PDE activity without acting on cGMP-PDE activity and to modulate PDE2 and PDE4 expressions in HUVECs. The present results suggest that curcumin exerts its in vitro anti-angiogenic and in vivo anti-tumour properties through combined PDE2 and PDE4 inhibition.

  15. Model predictive control for nonlinear parabolic system using wavelet base%基于小波基的非线性抛物型系统模型预测控制

    Institute of Scientific and Technical Information of China (English)

    艾岭

    2015-01-01

    针对一类由非线性抛物型描述的分布参数系统,研究了一种基于小波分解的模型降阶和预测控制方法。利用小波配点方法,分别将一阶和二阶空间偏导数投影到拟Shannon小波基上,不需要求解系统的主导极点,得到系统的低阶常微分方程逼近模型;采用前向Eular方法离散化时间变量,将得到的差分方程组模型作为系统的预测模型,选择标准二次优化性能指标,设计相应的非线性预测控制器;将此方法应用到由一个放置在反应器中的细长催化棒组成的传输-反应系统的温度场控制问题中,取得了满意的控制效果。%For a class of nonlinear parabolic distributed parameter systems, model reduction and predic-tive control method were investigated. First, the first order and second order spatial partial derivative were projected to quasi-Shannon wavelet using wavelet collocation method respectively, eliminating the need of knowledge of solution of dominant pole of the system. The correspondent lower order model was obtained. A group of ordinary differential equations obtained through Eular’ s discretizing time variable was selected as the predictive model of the system, standard quadratic optimization performance index was selected, and the corresponding nonlinear predictive controller was designed. This method was applied to the transfer-reaction system of catalytic rod, and simulation results indicate that the proposed method meets the requirements of system control.

  16. Difference schemes with intrinsic parallelism for quasi-linear parabolic systems

    Institute of Scientific and Technical Information of China (English)

    周毓麟

    1997-01-01

    The boundary value problem for quasi-linear parabolic system is solved by the finite difference method with intrinsic parallelism The existence and uniqueness and convergence theorems of the discrete vector solu tions of the nonlinear difference system with intrinsic parallelism are proved The limiting vector function is just the unique generalized solution of the original problem for the parabolic system

  17. Approximate solution of a nonlinear partial differential equation

    NARCIS (Netherlands)

    Vajta, M.

    2007-01-01

    Nonlinear partial differential equations (PDE) are notorious to solve. In only a limited number of cases can we find an analytic solution. In most cases, we can only apply some numerical scheme to simulate the process described by a nonlinear PDE. Therefore, approximate solutions are important for t

  18. Session: Parabolic Troughs (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Kutscher, C.

    2008-04-01

    The project description is R and D activities at NREL and Sandia aimed at lowering the delivered energy cost of parabolic trough collector systems and FOA awards to support industry in trought development. The primary objectives are: (1) support development of near-term parabolic trought technology for central station power generation; (2) support development of next-generation trought fields; and (3) support expansion of US trough industry. The major FY08 activities were: (1) improving reflector optics; (2) reducing receiver heat loss (including improved receiver coating and mitigating hydrogen accumulation); (3) measuring collector optical efficiency; (4) optimizing plant performance and reducing cost; (5) reducing plant water consumption; and (6) directly supporting industry needs, including FOA support.

  19. Parabolic Stein Manifolds

    CERN Document Server

    Aytuna, Aydin

    2011-01-01

    An open Riemann surface is called parabolic in case every bounded subharmonic function on it reduces to a constant. Several authors introduced seemingly different analogs of this notion for Stein manifolds of arbitrary dimension. In the first part of this note we compile these notions of parabolicity and give some immediate relations among them. In section 3 we relate some of these notions to the linear topological type of the Fr\\'echet space of analytic functions on the given manifold. In sections 4 and 5 we look at some examples and show, for example, that the complement of the zero set of a Weierstrass polynomial possesses a continuous plurisubharmonic exhaustion function that is maximal off a compact subset.

  20. Mahonians and parabolic quotients

    CERN Document Server

    Caselli, Fabrizio

    2011-01-01

    We study the distribution of the major index with sign on some parabolic quotients of the symmetric group, extending and generalizing simultaneously results of Panova [G. Panova, Bijective enumeration of permutations starting with a longest increasing subsequence, Discrete Math. Theor. Comput. Sci. Proc. AN (2010), 841--850], Gessel-Simion [M. Wachs, An involution for signed Eulerian numbers, Discrete Math. 99 (1992), 59--62] and Adin-Gessel-Roichman [R. Adin, I. Gessel and Y. Roichman, Signed Mahonians, J. Combin. Theory Ser. A 109 (2005), 25--43]. We further consider and compute the distribution of the flag-major index on some parabolic quotients of wreath products and other related groups. All these distributions turn out to have very simple factorization formulas.

  1. DSG槽式太阳能集热器非线性分布参数模型及动态特性%Nonlinear Distributed Parameter Model and Dynamic Characteristics of Parabolic Trough Direct Steam Generation Solar Collectors

    Institute of Scientific and Technical Information of China (English)

    郭苏; 刘德有; 张耀明; 许昌; 王沛

    2014-01-01

    直接蒸汽发电(direct steam generation,DSG)槽式太阳能热发电系统的集热器长度一般很长,且具有明显的分布参数特征。因此,建立DSG槽式太阳能集热器的非线性分布参数模型,以DSG集热器入口工质温度、质量流量和出口压力为边界条件,采用迎风格式的有限差分法对模型进行离散求解。仿真研究了DSG集热器主要参数在太阳辐射强度、给水温度和给水流量变化等扰动工况下的响应特性,结果与文献实验结果基本一致,验证了模型的正确性。结果表明:太阳辐射强度降低时,出口工质温度下降得很快;给水流量或给水温度小幅下降时,出口工质温度和流量都会滞后响应且变化显著;DSG 集热器出口工质流量在某些情况下会发生脉动,实际应用中应避免脉动状态的发生或降低其影响。%Direct steam generation (DSG) in parabolic trough solar power system has long solar collector and obvious distributed parameter characteristics. Therefore, a nonlinear distributed parameter model for parabolic trough DSG solar collectors was built in this paper. As a boundary condition, fluid temperature and mass flow had to be provided at the inlet as well as the pressure at the outlet, and the finite differential approach with an upwind scheme was adopted to discrete and solve the model. Compared with experimental results from the literature, the correctness of the model was validated by simulation results during the main conditions such as solar radiation intensity, inlet fluid temperature and inlet mass flow change. Simulation results show that fluid temperature at the outlet decreases quickly when solar radiation intensity is declined; Furthermore, the responses of fluid temperature and mass flow at the outlet delay largely and stabilize slowly when mass flow or temperature at the inlet declined slightly; Most significantly, a pulsation phenomenon of outlet mass flow may happen

  2. Time-parallel iterative methods for parabolic PDES: Multigrid waveform relaxation and time-parallel multigrid

    Energy Technology Data Exchange (ETDEWEB)

    Vandewalle, S. [Caltech, Pasadena, CA (United States)

    1994-12-31

    Time-stepping methods for parabolic partial differential equations are essentially sequential. This prohibits the use of massively parallel computers unless the problem on each time-level is very large. This observation has led to the development of algorithms that operate on more than one time-level simultaneously; that is to say, on grids extending in space and in time. The so-called parabolic multigrid methods solve the time-dependent parabolic PDE as if it were a stationary PDE discretized on a space-time grid. The author has investigated the use of multigrid waveform relaxation, an algorithm developed by Lubich and Ostermann. The algorithm is based on a multigrid acceleration of waveform relaxation, a highly concurrent technique for solving large systems of ordinary differential equations. Another method of this class is the time-parallel multigrid method. This method was developed by Hackbusch and was recently subject of further study by Horton. It extends the elliptic multigrid idea to the set of equations that is derived by discretizing a parabolic problem in space and in time.

  3. Chemical Principle and PDE of Variational Electrodynamics

    CERN Document Server

    De Luca, Jayme

    2016-01-01

    We study the problem of selecting a bounded two-body orbit exerting a vanishing electrical force on a third charge located outside a core region. The former infinite-dimensional PDE problem is called here the Chemical principle for the hydrogenoid atom of variational electrodynamics. For orbits with velocity discontinuities satisfying mild conditions at breaking points we introduce the delay and synchronization functions and prove a musical Lemma of synchronization-at-a-distance. We derive the leading PDE of the Chemical principle by removing the accelerations using the equations of motion approximated by keeping only the terms with the most singular denominators.

  4. A cell complex structure for the space of heteroclines for a semilinear parabolic equation

    Directory of Open Access Journals (Sweden)

    Michael Robinson

    2009-01-01

    Full Text Available It is well known that for many semilinear parabolic equations there is a global attractor which has a cell complex structure with finite dimensional cells. Additionally, many semilinear parabolic equations have equilibria with finite dimensional unstable manifolds. In this article, these results are unified to show that for a specific parabolic equation on an unbounded domain, the space of heteroclinic orbits has a cell complex structure with finite dimensional cells. The result depends crucially on the choice of spatial dimension and the degree of the nonlinearity in the parabolic equation, and thereby requires some delicate treatment.

  5. Analysis and implementation issues for the numerical approximation of parabolic equations with random coefficients

    KAUST Repository

    Nobile, Fabio

    2009-11-05

    We consider the problem of numerically approximating statistical moments of the solution of a time- dependent linear parabolic partial differential equation (PDE), whose coefficients and/or forcing terms are spatially correlated random fields. The stochastic coefficients of the PDE are approximated by truncated Karhunen-Loève expansions driven by a finite number of uncorrelated random variables. After approxi- mating the stochastic coefficients, the original stochastic PDE turns into a new deterministic parametric PDE of the same type, the dimension of the parameter set being equal to the number of random variables introduced. After proving that the solution of the parametric PDE problem is analytic with respect to the parameters, we consider global polynomial approximations based on tensor product, total degree or sparse polynomial spaces and constructed by either a Stochastic Galerkin or a Stochastic Collocation approach. We derive convergence rates for the different cases and present numerical results that show how these approaches are a valid alternative to the more traditional Monte Carlo Method for this class of problems. © 2009 John Wiley & Sons, Ltd.

  6. Dual PDE3/4 and PDE4 inhibitors: novel treatments for COPD and other inflammatory airway diseases.

    Science.gov (United States)

    Abbott-Banner, Katharine H; Page, Clive P

    2014-05-01

    Selective phosphodiesterase (PDE) 4 and dual PDE3/4 inhibitors have attracted considerable interest as potential therapeutic agents for the treatment of respiratory diseases, largely by virtue of their anti-inflammatory (PDE4) and bifunctional bronchodilator/anti-inflammatory (PDE3/4) effects. Many of these agents have, however, failed in early development for various reasons, including dose-limiting side effects when administered orally and lack of sufficient activity when inhaled. Indeed, only one selective PDE4 inhibitor, the orally active roflumilast-n-oxide, has to date received marketing authorization. The majority of the compounds that have failed were, however, orally administered and non-selective for either PDE3 (A,B) or PDE4 (A,B,C,D) subtypes. Developing an inhaled dual PDE3/4 inhibitor that is rapidly cleared from the systemic circulation, potentially with subtype specificity, may represent one strategy to improve the therapeutic index and also exhibit enhanced efficacy versus inhibition of either PDE3 or PDE4 alone, given the potential positive interactions with regard to anti-inflammatory and bronchodilator effects that have been observed pre-clinically with dual inhibition of PDE3 and PDE4 compared with inhibition of either isozyme alone. This MiniReview will summarize recent clinical data obtained with PDE inhibitors and the potential for these drugs to treat COPD and other inflammatory airways diseases such as asthma and cystic fibrosis.

  7. TRAVELING WAVE FRONTS OF A DEGENERATE PARABOLIC EQUATION WITH NON-DIVERGENCE FORM

    Institute of Scientific and Technical Information of China (English)

    王春朋; 尹景学

    2003-01-01

    We study the traveling wave solutions of a nonlinear degenerate parabolic equation with non-divergence form. Under some conditions on the source, we establish the existence, and then discuss the regularity of such solutions.

  8. Comprehensive analysis of passive generation of parabolic similaritons in tapered hydrogenated amorphous silicon photonic wires.

    Science.gov (United States)

    Mei, Chao; Li, Feng; Yuan, Jinhui; Kang, Zhe; Zhang, Xianting; Yan, Binbin; Sang, Xinzhu; Wu, Qiang; Zhou, Xian; Zhong, Kangping; Wang, Liang; Wang, Kuiru; Yu, Chongxiu; Wai, P K A

    2017-06-19

    Parabolic pulses have important applications in both basic and applied sciences, such as high power optical amplification, optical communications, all-optical signal processing, etc. The generation of parabolic similaritons in tapered hydrogenated amorphous silicon photonic wires at telecom (λ ~ 1550 nm) and mid-IR (λ ≥ 2100 nm) wavelengths is demonstrated and analyzed. The self-similar theory of parabolic pulse generation in passive waveguides with increasing nonlinearity is presented. A generalized nonlinear Schrödinger equation is used to describe the coupled dynamics of optical field in the tapered hydrogenated amorphous silicon photonic wires with either decreasing dispersion or increasing nonlinearity. The impacts of length dependent higher-order effects, linear and nonlinear losses including two-photon absorption, and photon-generated free carriers, on the pulse evolutions are characterized. Numerical simulations show that initial Gaussian pulses will evolve into the parabolic pulses in the waveguide taper designed.

  9. Courant Algebroids in Parabolic Geometry

    CERN Document Server

    Armstrong, Stuart

    2011-01-01

    To a smooth manifold $M$, a parabolic geometry associates a principal bundle, which has a parabolic subgroup of a semisimple Lie group as its structure group, and a Cartan connection. We show that the adjoint tractor bundle of a regular normal parabolic geometry can be endowed with the structure of a Courant algebroid. This gives a class of examples of transitive Courant algebroids that are not exact.

  10. 非线性抛物积分微分方程的类Wilson非协调元分析%Analysis of Quasi-Wilson Nonconforming Element for Nonlinear Parabolic Integro-differential Equation

    Institute of Scientific and Technical Information of China (English)

    王芬玲; 石东洋; 陈金环

    2012-01-01

    在半离散和全离散格式下讨论非线性抛物积分微分方程的类Wilson非协调有限元逼近.当问题的精确解u∈H3(Ω)/H4(Ω)时,利用该元的相容误差在能量模意义下可以达到O(h2 )/O(h3)比其插值误差高一阶和二阶的特殊性质,再结合协调部分的高精度分析及插值后处理技术,并借助于双线性插值代替传统有限元分析中不可缺少的Ritz-Volterra投影导出了半离散格式下的O(h2)阶超逼近和超收敛结果.同时分别得到了向后Euler全离散格式下的超逼近性和Crank-Nicolson全离散格式下的最优误差估计.%A nonconforming quasi-Wilson finite element approximation for nonlinear parabolic integro-differential equation is discussed under the semi-discrete and fully-discrete schemes. By use of the special property of the element,i. e. , the consistence error estimate in energy norm when the exact solution u of the problem belongs to H3(Ω)/ H4(Ω) can reach to O(h2)/O(h3), one/two order higher than the interpolation error, then combination it with the higher accuracy analysis of its conforming part and the interpolated postprocessing technique, the superclose and superconvergence results with order O(h2) are obtained for semi-discrete scheme through interpolation instead of the Ritz-Volterra projection which is an indispensable tool in traditional finite element analysis. The superclose property and the optimal error estimate for backward Euler and Crank-Nicolson fully-discrete schemes are derived , respectively.

  11. Almost periodic solutions to systems of parabolic equations

    Directory of Open Access Journals (Sweden)

    Janpou Nee

    1994-01-01

    Full Text Available In this paper we show that the second-order differential solution is 2-almost periodic, provided it is 2-bounded, and the growth of the components of a non-linear function of a system of parabolic equation is bounded by any pair of con-secutive eigenvalues of the associated Dirichlet boundary value problems.

  12. Steadily translating parabolic dissolution fingers

    CERN Document Server

    Kondratiuk, Paweł

    2015-01-01

    Dissolution fingers (or wormholes) are formed during the dissolution of a porous rock as a result of nonlinear feedbacks between the flow, transport and chemical reactions at pore surfaces. We analyze the shapes and growth velocities of such fingers within the thin-front approximation, in which the reaction is assumed to take place instantaneously with the reactants fully consumed at the dissolution front. We concentrate on the case when the main flow is driven by the constant pressure gradient far from the finger, and the permeability contrast between the inside and the outside of the finger is finite. Using Ivantsov ansatz and conformal transformations we find the family of steadily translating fingers characterized by a parabolic shape. We derive the reactant concentration field and the pressure field inside and outside of the fingers and show that the flow within them is uniform. The advancement velocity of the finger is shown to be inversely proportional to its radius of curvature in the small P\\'{e}clet...

  13. Effects of icariin on cGMP—specific PDE5 and cAMP—specific PDE4 activities

    Institute of Scientific and Technical Information of China (English)

    ZCXin; EKKim; CSLin; WJLiu; LTian; YMYuan; JFu

    2003-01-01

    Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [3H]-c GMP/[3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED.

  14. Estimates on Blow-up Rate of Nonlinear Parabolic Systems with Nonlinear Boundary Conditions%带有非线性边界条件的非线性抛物型方程组的爆破速率估计

    Institute of Scientific and Technical Information of China (English)

    刘卫岭; 李国富

    2005-01-01

    In this paper, the estimate on blow-up rate of the following nonlinear parabolic system is considered:{ut=uxx+ul11vl12,vt=uxx+ul21vl22,(x,t)∈(0,1)(×)(0,T),ux(0,t)=0,vx(0,t)=0,t∈(0,T),ux(1,t)=(up11vp12)(1,t),vx(1,t)=(up21vp22)(1,t),t∈(0,T),u(x,0)=u0(x)1v(x,0)=v0(x),x∈(0,1).We will prove that there exist two positive constants such that: cx∈[0,1] ≤ max u(x,t)(T-t)r/(l1-1)≤C,0 < t < T, c ≤ max x∈[0,1] v(x,t)(T-t)1/(t1-1)≤C,0<t<T,where l1 =l2iα/α2 + l22,r = α1/α2 > 1, α1 ≤α2 < 0.

  15. Regularity for solutions of non local parabolic equations

    CERN Document Server

    Lara, Héctor A Chang

    2011-01-01

    We study the regularity of solutions of parabolic fully nonlinear nonlocal equations. We proof $C^\\a$ regularity in space and time and for translation invariant equations and under different assumptions on the kernels $C^{1,\\a}$ in space and time regularity. The proofs rely on a weak parabolic ABP inspired in recent work done by L. Silvestre and the classic ideas of K. Tso and L. Wang. Our results remain uniform as $\\s\\to2$ allowing us to understand the non local theory as an extension to the classical one.

  16. SURFACE FINITE ELEMENTS FOR PARABOLIC EQUATIONS

    Institute of Scientific and Technical Information of China (English)

    G. Dziuk; C.M. Elliott

    2007-01-01

    In this article we define a surface finite element method (SFEM) for the numerical solution of parabolic partial differential equations on hypersurfaces Γ in (R)n+1. The key idea is based on the approximation of Γ by a polyhedral surface Γh consisting of a union of simplices (triangles for n = 2, intervals for n = 1) with vertices on Γ. A finite element space of functions is then defined by taking the continuous functions on Γh which are linear affine on each simplex of the polygonal surface. We use surface gradients to define weak forms of elliptic operators and naturally generate weak formulations of elliptic and parabolic equations on Γ. Our finite element method is applied to weak forms of the equations. The computation of the mass and element stiffness matrices are simple and straightforward.We give an example of error bounds in the case of semi-discretization in space for a fourth order linear problem. Numerical experiments are described for several linear and nonlinear partial differential equations. In particular the power of the method is demonstrated by employing it to solve highly nonlinear second and fourth order problems such as surface Allen-Cahn and Cahn-Hilliard equations and surface level set equations for geodesic mean curvature flow.

  17. Decomposition method for solving parabolic equations in finite domains

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    This paper presents a comparison among Adomian decomposition method (ADM), Wavelet-Galerkin method (WGM),the fully explicit (1,7) finite difference technique (FTCS), the fully implicit (7,1) finite difference method (BTCS), (7,7)Crank-Nicholson type finite difference formula (C-N), the fully explicit method (1,13) and 9-point finite difference method, for solving parabolic differential equations with arbitrary boundary conditions and based on weak form functionals in finite domains.The problem is solved rapidly, easily and elegantly by ADM. The numerical results on a 2D transient heat conducting problem and 3D diffusion problem are used to validate the proposed ADM as an effective numerical method for solving finite domain parabolic equations. The numerical results showed that our present method is less time consuming and is easier to use than other methods. In addition, we prove the convergence of this method when it is applied to the nonlinear parabolic equation.

  18. Robust H∞ Control for a Class of Nonlinear Distributed Parameter Systems via Proportional-Spatial Derivative Control Approach

    Directory of Open Access Journals (Sweden)

    Cheng-Dong Yang

    2014-01-01

    Full Text Available This paper addresses the problem of robust H∞ control design via the proportional-spatial derivative (P-sD control approach for a class of nonlinear distributed parameter systems modeled by semilinear parabolic partial differential equations (PDEs. By using the Lyapunov direct method and the technique of integration by parts, a simple linear matrix inequality (LMI based design method of the robust H∞ P-sD controller is developed such that the closed-loop PDE system is exponentially stable with a given decay rate and a prescribed H∞ performance of disturbance attenuation. Moreover, a suboptimal H∞ controller is proposed to minimize the attenuation level for a given decay rate. The proposed method is successfully employed to address the control problem of the FitzHugh-Nagumo (FHN equation, and the achieved simulation results show its effectiveness.

  19. A Riccati type PDE for light-front higher helicity vertices

    Science.gov (United States)

    Bengtsson, Anders K. H.

    2014-09-01

    This paper is based on a curious observation about an equation related to the tracelessness constraints of higher spin gauge fields. A similar equation also occurs in the theory of continuous spin representations of the Poincaré group. Expressed in an oscillator basis for the higher spin fields, the equation becomes a non-linear partial differential operator of the Riccati type acting on the vertex functions. The consequences of the equation for the cubic vertex is investigated in the light-front formulation of higher spin theory. The vertex is fixed by the PDE up to a set of terms that can be considered as boundary data for the PDE. These terms can serve as off-shell quantum corrections.

  20. Commercialization of parabolic dish systems

    Science.gov (United States)

    Washom, B.

    1982-01-01

    The impact of recent federal tax and regulatory legislation on the commercialization of parabolic solar reflector technology is assessed. Specific areas in need of technical or economic improvement are noted.

  1. Invariant foliations for parabolic equations

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    It is proved for parabolic equations that under certain conditions the weak (un-)stable manifolds possess invariant foliations, called strongly (un-)stable foliations. The relevant results on center manifolds are generalized to weak hyperbolic manifolds.

  2. The planar parabolic optical antenna.

    Science.gov (United States)

    Schoen, David T; Coenen, Toon; García de Abajo, F Javier; Brongersma, Mark L; Polman, Albert

    2013-01-09

    One of the simplest and most common structures used for directing light in macroscale applications is the parabolic reflector. Parabolic reflectors are ubiquitous in many technologies, from satellite dishes to hand-held flashlights. Today, there is a growing interest in the use of ultracompact metallic structures for manipulating light on the wavelength scale. Significant progress has been made in scaling radiowave antennas to the nanoscale for operation in the visible range, but similar scaling of parabolic reflectors employing ray-optics concepts has not yet been accomplished because of the difficulty in fabricating nanoscale three-dimensional surfaces. Here, we demonstrate that plasmon physics can be employed to realize a resonant elliptical cavity functioning as an essentially planar nanometallic structure that serves as a broadband unidirectional parabolic antenna at optical frequencies.

  3. Higher-order effects on self-similar parabolic pulse in the microstructured fibre amplifier

    Institute of Scientific and Technical Information of China (English)

    Liu Wei-Ci; Xu Wen-Cheng; Feng Jie; Chen Wei-Cheng; Li Shu-Xian; Lin Song-Hao

    2008-01-01

    By considering higher-order effects, the properties of self-similar parabolic pulses propagating in the microstructured fibre amplifier with a normal group-velocity dispersion have been investigated. The numerical results indicate that the higher-order effects can badly distort self-similar parabolic pulse shape and optical spectrum, and at the same time the peak shift and oscillation appear, while the pulse still reveals highly linear chirp but grows into asymmetry. The influence of different higher-order effects on self-similar parabolic pulse propagation has been analysed. It shows thatthe self-steepening plays a more important role. We can manipulate the geometrical parameters of the microstructured fibre amplifier to gain a suitable dispersion and nonlinearity coefficient which will keep high-quality self-similar parabolic pulse propagation. These results are significant for the further study of self-similar parabolic pulse propagation.

  4. Parabolic sheaves on logarithmic schemes

    OpenAIRE

    Borne, Niels; Vistoli, Angelo

    2010-01-01

    We show how the natural context for the definition of parabolic sheaves on a scheme is that of logarithmic geometry. The key point is a reformulation of the concept of logarithmic structure in the language of symmetric monoidal categories, which might be of independent interest. Our main result states that parabolic sheaves can be interpreted as quasi-coherent sheaves on certain stacks of roots.

  5. Parabolic metamaterials and Dirac bridges

    Science.gov (United States)

    Colquitt, D. J.; Movchan, N. V.; Movchan, A. B.

    2016-10-01

    A new class of multi-scale structures, referred to as `parabolic metamaterials' is introduced and studied in this paper. For an elastic two-dimensional triangular lattice, we identify dynamic regimes, which corresponds to so-called `Dirac Bridges' on the dispersion surfaces. Such regimes lead to a highly localised and focussed unidirectional beam when the lattice is excited. We also show that the flexural rigidities of elastic ligaments are essential in establishing the `parabolic metamaterial' regimes.

  6. Nonlinear Localized Dissipative Structures for Long-Time Solution of Wave Equation

    Science.gov (United States)

    2009-07-01

    interesting that the role of the second order term (£0) in equation (2.11) is different from typical nonlinear pde’s studied, such as KdV , that harbor...the commonly used form of the CH equation. An important point is that other nonlinear pde’s like Kdv , which can successfully propagate localized

  7. Differential expression and function of PDE8 and PDE4 in effector T cells: Implications for PDE8 as a drug target in inflammation.

    Directory of Open Access Journals (Sweden)

    Amanda G. Vang

    2016-08-01

    Full Text Available Abolishing the inhibitory signal of intracellular cAMP is a prerequisite for effector T (Teff cell function. The regulation of cAMP within leukocytes critically depends on its degradation by cyclic nucleotide phosphodiesterases (PDEs. We have previously shown that PDE8A, a PDE isoform with 40-100-fold greater affinity for cAMP than PDE4, is selectively expressed in Teff versus regulatory T (Treg cells and controls CD4+ Teff cell adhesion and chemotaxis. Here, we determined PDE8A expression and function in CD4+ Teff cell populations in vivo. Using magnetic bead separation to purify leukocyte populations from the lung draining hilar lymph node (HLN in a mouse model of ovalbumin-induced allergic airway disease (AAD, we found by Western immunoblot and quantitative (qRT-PCR that PDE8A protein and gene expression are enhanced in the CD4+ T cell fraction over the course of the acute inflammatory disease and recede at the late tolerant non-inflammatory stage. To evaluate PDE8A as a potential drug target, we compared the selective and combined effects of the recently characterized highly potent PDE8-selective inhibitor PF-04957325 with the PDE4-selective inhibitor piclamilast (PICL. As previously shown, PF-04957325 suppresses T cell adhesion to endothelial cells. In contrast, we found that PICL alone increased firm T cell adhesion to endothelial cells by approximately 20% and significantly abrogated the inhibitory effect of PF-04957325 on T cell adhesion by over 50% when cells were co-exposed to PICL and PF-04957325. Despite its robust effect on T cell adhesion, PF-04957325 was over two orders of magnitude less efficient than PICL in suppressing polyclonal Teff cell proliferation, and showed no effect on cytokine gene expression in these cells. More importantly, PDE8 inhibition did not suppress proliferation and cytokine production of myelin-antigen reactive proinflammatory Teff cells in vivo and in vitro. Thus, targeting PDE8 through PF-04957325

  8. Parabolic aircraft solidification experiments

    Science.gov (United States)

    Workman, Gary L. (Principal Investigator); Smith, Guy A.; OBrien, Susan

    1996-01-01

    A number of solidification experiments have been utilized throughout the Materials Processing in Space Program to provide an experimental environment which minimizes variables in solidification experiments. Two techniques of interest are directional solidification and isothermal casting. Because of the wide-spread use of these experimental techniques in space-based research, several MSAD experiments have been manifested for space flight. In addition to the microstructural analysis for interpretation of the experimental results from previous work with parabolic flights, it has become apparent that a better understanding of the phenomena occurring during solidification can be better understood if direct visualization of the solidification interface were possible. Our university has performed in several experimental studies such as this in recent years. The most recent was in visualizing the effect of convective flow phenomena on the KC-135 and prior to that were several successive contracts to perform directional solidification and isothermal casting experiments on the KC-135. Included in this work was the modification and utilization of the Convective Flow Analyzer (CFA), the Aircraft Isothermal Casting Furnace (ICF), and the Three-Zone Directional Solidification Furnace. These studies have contributed heavily to the mission of the Microgravity Science and Applications' Materials Science Program.

  9. Concentration phenomena in the semilinear parabolic equation

    Institute of Scientific and Technical Information of China (English)

    TAN; Zhong

    2001-01-01

    [1]Fujita, H., On the blowing up of solutions of the Chauch problem for u=Δu+u1+α, J. Fac. Sci. Univ. Tokyo Sect. I, 966, 3: 09.[2]Ni, W. -M., Sacks, P. E., Tavantzis, J., On the asymptotic behavior of solutions of certain quasilinear equations of parabolic type, J. Differential Equations, 984, 54: 97.[3]Cazenave, T., Lions, P. L., Solutions globales d'equations de la chaleur semilineaires, Comm. in Partial Differential Equations, 984, 9(0): 955.[4]Giga, Y., A bound for global solutions of semilinear heat equations, Commun. Math. Phys., 986, 03: 45.[5]Galaktionov, V., Vazquez, J. L., Continuation of blow-up solutions of nonlinear heat equations in several space dimensions, Comm. Pure Appl. Math., 997, 50: .[6]Rey, O., The role of the Green's function in a nonlinear elliptic equation involving the critical Sobolev exponent, J. Func. Anal., 990, 89: .[7]Wei Juncheng, Asymptotic behavior of least energy solution to a semilinear Dirichlet problem near the critical exponent, J. Math. Soc. Japan, 998, 50(): 39.[8]Lions, P. L., The concentration-compactness principle in the calculus of variations, The limit case ,2, Rev. Mat. Iberoamerioana, 985, : 45, 45.[9]Brezis, H., Elliptic equations with limiting Sobolev exponents——the impact of topology, Commun. Pure and Appl. Math., 986, XXXXIX: S7.[10]Sacks, J., Uhlenbeck, K., The existence of minimal immersions of 2-spheres, Ann. Math., 98, 3: .[11]Zhu Xiping, Nontrivial solutions of quasilinear elliptic equation involving critical growth, Science in China (in Chinese), Ser. A, 988, (3): 225.[12]Pohozaev, S. I., Eigenfunctions of the equation -Δu+λf(u)=0, Soviet. Math. Dold., 965, 6: 408.[13]Gidas, B., Ni, W. -M., Nirenberg, L., Symmetry and related properties via the maximum principle, Comm. Math. Phys., 979, 68: 209.[14]Ni, W. -M., Sacks, P. E., Singular behaviour in nonlinear parabolic equations, Tran. of the AMS, 985, 287(2): 657.[15]Ni, W. -M., Sacks, P. E

  10. A discussion of a homogenization procedure for a degenerate linear hyperbolic-parabolic problem

    Science.gov (United States)

    Flodén, L.; Holmbom, A.; Jonasson, P.; Lobkova, T.; Lindberg, M. Olsson; Zhang, Y.

    2017-01-01

    We study the homogenization of a hyperbolic-parabolic PDE with oscillations in one fast spatial scale. Moreover, the first order time derivative has a degenerate coefficient passing to infinity when ɛ→0. We obtain a local problem which is of elliptic type, while the homogenized problem is also in some sense an elliptic problem but with the limit for ɛ-1∂tuɛ as an undetermined extra source term in the right-hand side. The results are somewhat surprising and work remains to obtain a fully rigorous treatment. Hence the last section is devoted to a discussion of the reasonability of our conjecture including numerical experiments.

  11. The emperor's new clothes: PDE5 and the heart.

    Directory of Open Access Journals (Sweden)

    Chantal V Degen

    Full Text Available Phosphodiesterase-5 (PDE5 is highly expressed in the pulmonary vasculature, but its expression in the myocardium is controversial. Cyclic guanosine monophosphate (cGMP activates protein kinase G (PKG, which has been hypothesized to blunt cardiac hypertrophy and negative remodeling in heart failure. Although PDE5 has been suggested to play a significant role in the breakdown of cGMP in cardiomyocytes and hence PKG regulation in the myocardium, the RELAX trial, which tested effect of PDE5 inhibition on exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF failed to show a beneficial effect. These results highlight the controversy regarding the role and expression of PDE5 in the healthy and failing heart. This study used one- and two-dimensional electrophoresis and Western blotting to examine PDE5 expression in mouse (before and after trans-aortic constriction, dog (control and HFpEF as well as human (healthy and failing heart. We were unable to detect PDE5 in any cardiac tissue lysate, whereas PDE5 was present in the murine and bovine lung samples used as positive controls. These results indicate that if PDE5 is expressed in cardiac tissue, it is present in very low quantities, as PDE5 was not detected in either humans or any model of heart failure examined. Therefore in cardiac muscle, it is unlikely that PDE5 is involved the regulation of cGMP-PKG signaling, and hence PDE5 does not represent a suitable drug target for the treatment of cardiac hypertrophy. These results highlight the importance of rigorous investigation prior to clinical trial design.

  12. Blow-up of a hyperbolic equation of viscoelasticity with supercritical nonlinearities

    Science.gov (United States)

    Guo, Yanqiu; Rammaha, Mohammad A.; Sakuntasathien, Sawanya

    2017-02-01

    We investigate a hyperbolic PDE, modeling wave propagation in viscoelastic media, under the influence of a linear memory term of Boltzmann type, and a nonlinear damping modeling friction, as well as an energy-amplifying supercritical nonlinear source:

  13. Positive solutions of some parabolic system with cross-diffusion and nonlocal initial conditions

    CERN Document Server

    Walker, Christoph

    2010-01-01

    The paper is concerned with a system consisting of two coupled nonlinear parabolic equations with a cross-diffusion term, where the solutions at positive times define the initial states. The equations arise as steady state equations of an age-structured predator-prey system with spatial dispersion. Based on unilateral global bifurcation methods for Fredholm operators and on maximal regularity for parabolic equations, global bifurcation of positive solutions is derived.

  14. Engineering parabolic beams with dynamic intensity profiles.

    Science.gov (United States)

    Ruelas, Adrian; Lopez-Aguayo, Servando; Gutiérrez-Vega, Julio C

    2013-08-01

    We present optical fields formed by superposing nondiffracting parabolic beams with distinct longitudinal wave-vector components, generating light profiles that display intensity fluxes following parabolic paths in the transverse plane. Their propagation dynamics vary depending on the physical mechanism originating interference, where the possibilities include constructive and destructive interference between traveling parabolic beams, interference between stationary parabolic modes, and combinations of these. The dark parabolic region exhibited by parabolic beams permits a straightforward superposition of intensity fluxes, allowing formation of a variety of profiles, which can exhibit circular, elliptic, and other symmetries.

  15. Parabolic similariton Yb-fiber laser with triangular pulse evolution

    Science.gov (United States)

    Wang, Sijia; Wang, Lei

    2016-04-01

    We propose a novel mode-locked fiber laser design which features a passive nonlinear triangular pulse formation and self-similar parabolic pulse amplification intra cavity. Attribute to the nonlinear reshaping progress in the passive fiber, a triangular-profiled pulse with negative-chirp is generated and paved the way for rapid and efficient self-similar parabolic evolution in a following short-length high-gain fiber. In the meanwhile, the accompanied significantly compressed narrow spectrum from this passive nonlinear reshaping also gives the promise of pulse stabilization and gain-shaping robustness without strong filtering. The resulting short average intra-cavity pulse duration, low amplified spontaneous emission (ASE) and low intra-cavity power loss are essential for the low-noise operation. Simulations predict this modelocked fiber laser allows for high-energy ultra-short transform-limited pulse generation exceeding the gain bandwidth. The output pulse has a de-chirped duration (full-width at half maximum, FWHM) of 27 fs. In addition to the ultrafast laser applications, the proposed fiber laser scheme can support low-noise parabolic and triangular pulse trains at the same time, which are also attractive in optical pulse shaping, all-optical signal processing and high-speed communication applications.

  16. PDE regularization for Bayesian reconstruction of emission tomography

    Science.gov (United States)

    Wang, Zhentian; Zhang, Li; Xing, Yuxiang; Zhao, Ziran

    2008-03-01

    The aim of the present study is to investigate a type of Bayesian reconstruction which utilizes partial differential equations (PDE) image models as regularization. PDE image models are widely used in image restoration and segmentation. In a PDE model, the image can be viewed as the solution of an evolutionary differential equation. The variation of the image can be regard as a descent of an energy function, which entitles us to use PDE models in Bayesian reconstruction. In this paper, two PDE models called anisotropic diffusion are studied. Both of them have the characteristics of edge-preserving and denoising like the popular median root prior (MRP). We use PDE regularization with an Ordered Subsets accelerated Bayesian one step late (OSL) reconstruction algorithm for emission tomography. The OS accelerated OSL algorithm is more practical than a non-accelerated one. The proposed algorithm is called OSEM-PDE. We validated the OSEM-PDE using a Zubal phantom in numerical experiments with attenuation correction and quantum noise considered, and the results are compared with OSEM and an OS version of MRP (OSEM-MRP) reconstruction. OSEM-PDE shows better results both in bias and variance. The reconstruction images are smoother and have sharper edges, thus are more applicable for post processing such as segmentation. We validate this using a k-means segmentation algorithm. The classic OSEM is not convergent especially in noisy condition. However, in our experiment, OSEM-PDE can benefit from OS acceleration and keep stable and convergent while OSEM-MRP failed to converge.

  17. Shenandoah parabolic dish solar collector

    Energy Technology Data Exchange (ETDEWEB)

    Kinoshita, G.S.

    1985-01-01

    The objectives of the Shenandoah, Georgia, Solar Total Energy System are to design, construct, test, and operate a solar energy system to obtain experience with large-scale hardware systems for future applications. This report describes the initial design and testing activities conducted to select and develop a collector that would serve the need of such a solar total energy system. The parabolic dish was selected as the collector most likely to maximize energy collection as required by this specific site. The fabrication, testing, and installation of the parabolic dish collector incorporating improvements identified during the development testing phase are described.

  18. Shenandoah parabolic dish solar collector

    Energy Technology Data Exchange (ETDEWEB)

    Kinoshita, G.S.

    1985-01-01

    The objectives of the Shenandoah, Georgia, Solar Total Energy System are to design, construct, test, and operate a solar energy system to obtain experience with large-scale hardware systems for future applications. This report describes the initial design and testing activities conducted to select and develop a collector that would serve the need of such a solar total energy system. The parabolic dish was selected as the collector most likely to maximize energy collection as required by this specific site. The fabrication, testing, and installation of the parabolic dish collector incorporating improvements identified during the development testing phase are described.

  19. OPTIMAL CONTROL PROBLEM FOR PARABOLIC VARIATIONAL INEQUALITIES

    Institute of Scientific and Technical Information of China (English)

    汪更生

    2001-01-01

    This paper deals with the optimal control problems of systems governed by a parabolic variational inequality coupled with a semilinear parabolic differential equations.The maximum principle and some kind of approximate controllability are studied.

  20. PDE Nozzle Optimization Using a Genetic Algorithm

    Science.gov (United States)

    Billings, Dana; Turner, James E. (Technical Monitor)

    2000-01-01

    Genetic algorithms, which simulate evolution in natural systems, have been used to find solutions to optimization problems that seem intractable to standard approaches. In this study, the feasibility of using a GA to find an optimum, fixed profile nozzle for a pulse detonation engine (PDE) is demonstrated. The objective was to maximize impulse during the detonation wave passage and blow-down phases of operation. Impulse of each profile variant was obtained by using the CFD code Mozart/2.0 to simulate the transient flow. After 7 generations, the method has identified a nozzle profile that certainly is a candidate for optimum solution. The constraints on the generality of this possible solution remain to be clarified.

  1. PDE5 expression in human thyroid tumors and effects of PDE5 inhibitors on growth and migration of cancer cells.

    Science.gov (United States)

    Sponziello, Marialuisa; Verrienti, Antonella; Rosignolo, Francesca; De Rose, Roberta Francesca; Pecce, Valeria; Maggisano, Valentina; Durante, Cosimo; Bulotta, Stefania; Damante, Giuseppe; Giacomelli, Laura; Di Gioia, Cira Rosaria Tiziana; Filetti, Sebastiano; Russo, Diego; Celano, Marilena

    2015-11-01

    Recent studies have revealed in normal thyroid tissue the presence of the transcript of several phosphodiesterases (PDEs), enzymes responsible for the hydrolysis of cyclic nucleotides. In this work, we analyzed the expression of PDE5 in a series of human papillary thyroid carcinomas (PTCs) presenting or not BRAF V600E mutation and classified according to ATA risk criteria. Furthermore, we tested the effects of two PDE5 inhibitors (sildenafil, tadalafil) against human thyroid cancer cells. PDE5 gene and protein expression were analyzed in two different cohorts of PTCs by real-time PCR using a TaqMan micro-fluid card system and Western blot. MTT and migration assay were used to evaluate the effects of PDE5 inhibitors on proliferation and migration of TPC-1, BCPAP, and 8505C cells. In a first series of 36 PTCs, we found higher expression levels of PDE5A in tumors versus non-tumor (normal) tissues. PTCs with BRAF mutation showed higher levels of mRNA compared with those without mutation. No significant differences were detected between subgroups with low and intermediate ATA risk. Upregulation of PDE5 was also detected in tumor tissue proteins. Similar results were obtained analyzing the second cohort of 50 PTCs. Moreover, all tumor tissues with high PDE5 levels showed reduction of Thyroglobulin, TSH receptor, Thyroperoxidase, and NIS transcripts. In thyroid cancer cells in vitro, sildenafil and tadalafil determined a reduction of proliferation and cellular migration. Our findings demonstrate for the first time an overexpression of PDE5 in PTCs, and the ability of PDE5 inhibitors to block the proliferation of thyroid cancer cells in culture, therefore, suggesting that specific inhibition of PDE5 may be proposed for the treatment of these tumors.

  2. Plane and parabolic solar panels

    CERN Document Server

    Sales, J H O

    2009-01-01

    We present a plane and parabolic collector that absorbs radiant energy and transforms it in heat. Therefore we have a panel to heat water. We study how to increment this capture of solar beams onto the panel in order to increase its efficiency in heating water.

  3. Selective Extraction of Entangled Textures via Adaptive PDE Transform

    Directory of Open Access Journals (Sweden)

    Yang Wang

    2012-01-01

    Full Text Available Texture and feature extraction is an important research area with a wide range of applications in science and technology. Selective extraction of entangled textures is a challenging task due to spatial entanglement, orientation mixing, and high-frequency overlapping. The partial differential equation (PDE transform is an efficient method for functional mode decomposition. The present work introduces adaptive PDE transform algorithm to appropriately threshold the statistical variance of the local variation of functional modes. The proposed adaptive PDE transform is applied to the selective extraction of entangled textures. Successful separations of human face, clothes, background, natural landscape, text, forest, camouflaged sniper and neuron skeletons have validated the proposed method.

  4. Global Existence for a Parabolic-hyperbolic Free Boundary Problem Modelling Tumor Growth

    Institute of Scientific and Technical Information of China (English)

    Shang-bin Cui; Xue-mei Wei

    2005-01-01

    In this paper we study a free boundary problem modelling tumor growth, proposed by A. Friedman in 2004. This free boundary problem involves a nonlinear second-order parabolic equation describing the diffusion of nutrient in the tumor, and three nonlinear first-order hyperbolic equations describing the evolution of proliferative cells, quiescent cells and dead cells, respectively. By applying Lp theory of parabolic equations, the characteristic theory of hyperbolic equations, and the Banach fixed point theorem, we prove that this problem has a unique global classical solution.

  5. Evolution of laser pulse shape in a parabolic plasma channel

    Science.gov (United States)

    Kaur, M.; Gupta, D. N.; Suk, H.

    2017-01-01

    During high-intensity laser propagation in a plasma, the group velocity of a laser pulse is subjected to change with the laser intensity due to alteration in refractive index associated with the variation of the nonlinear plasma density. The pulse front sharpened while the back of the pulse broadened due to difference in the group velocity at different parts of the laser pulse. Thus the distortion in the shape of the laser pulse is expected. We present 2D particle-in-cell simulations demonstrating the controlling the shape distortion of a Gaussian laser pulse using a parabolic plasma channel. We show the results of the intensity distribution of laser pulse in a plasma with and without a plasma channel. It has been observed that the plasma channel helps in controlling the laser pulse shape distortion. The understanding of evolution of laser pulse shape may be crucial while applying the parabolic plasma channel for guiding the laser pulse in plasma based accelerators.

  6. Propagation equation for tight-focusing by a parabolic mirror.

    Science.gov (United States)

    Couairon, A; Kosareva, O G; Panov, N A; Shipilo, D E; Andreeva, V A; Jukna, V; Nesa, F

    2015-11-30

    Part of the chain in petawatt laser systems may involve extreme focusing conditions for which nonparaxial and vectorial effects have high impact on the propagation of radiation. We investigate the possibility of using propagation equations to simulate numerically the focal spot under these conditions. We derive a unidirectional propagation equation for the Hertz vector, describing linear and nonlinear propagation under situations where nonparaxial diffraction and vectorial effects become significant. By comparing our simulations to the results of vector diffraction integrals in the case of linear tight-focusing by a parabolic mirror, we establish a practical criterion for the critical f -number below which initializing a propagation equation with a parabolic input phase becomes inaccurate. We propose a method to find suitable input conditions for propagation equations beyond this limit. Extreme focusing conditions are shown to be modeled accurately by means of numerical simulations of the unidirectional Hertz-vector propagation equation initialized with suitable input conditions.

  7. A novel two-component system PdeK/PdeR regulates c-di-GMP turnover and virulence of Xanthomonas oryzae pv. oryzae.

    Science.gov (United States)

    Yang, Fenghuan; Tian, Fang; Sun, Lei; Chen, Huamin; Wu, Maosen; Yang, Ching-Hong; He, Chenyang

    2012-10-01

    Two-component systems (TCS) consisting of histidine kinases (HK) and response regulators (RR) play essential roles in bacteria to sense environmental signals and regulate cell functions. One type of RR is involved in metabolism of cyclic diguanylate (c-di-GMP), a ubiquitous bacterial second messenger. Although genomic studies predicted a large number of them existing in different bacteria, only a few have been studied. In this work, we characterized a novel TCS consisting of PdeK(PXO_01018)/PdeR(PXO_ 01019) from Xanthomonas oryzae pv. oryzae, which causes the bacterial leaf blight of rice. PdeR (containing GGDEF, EAL, and REC domains) was shown to have phosphodiesterase (PDE) activity in vitro by colorimetric assays and high-performance liquid chromatography analysis. The PDE activity of full-length PdeR needs to be triggered by HK PdeK. Deletion of pdeK or pdeR in X. oryzae pv. oryzae PXO99(A) had attenuated its virulence on rice. ΔpdeK and ΔpdeR secreted less exopolysaccharide than the wild type but there were no changes in terms of motility or extracellular cellulase activity, suggesting the activity of PdeK/PdeR might be specific.

  8. Numerical Methods for Pricing American Options with Time-Fractional PDE Models

    Directory of Open Access Journals (Sweden)

    Zhiqiang Zhou

    2016-01-01

    Full Text Available In this paper we develop a Laplace transform method and a finite difference method for solving American option pricing problem when the change of the option price with time is considered as a fractal transmission system. In this scenario, the option price is governed by a time-fractional partial differential equation (PDE with free boundary. The Laplace transform method is applied to the time-fractional PDE. It then leads to a nonlinear equation for the free boundary (i.e., optimal early exercise boundary function in Laplace space. After numerically finding the solution of the nonlinear equation, the Laplace inversion is used to transform the approximate early exercise boundary into the time space. Finally the approximate price of the American option is obtained. A boundary-searching finite difference method is also proposed to solve the free-boundary time-fractional PDEs for pricing the American options. Numerical examples are carried out to compare the Laplace approach with the finite difference method and it is confirmed that the former approach is much faster than the latter one.

  9. PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex.

    Science.gov (United States)

    Basole, Chaitali P; Nguyen, Rebecca K; Lamothe, Katie; Vang, Amanda; Clark, Robert; Baillie, George S; Epstein, Paul M; Brocke, Stefan

    2017-08-26

    The levels of cAMP are regulated by phosphodiesterase enzymes (PDEs), which are targets for the treatment of inflammatory disorders. We have previously shown that PDE8 regulates T cell motility. Here, for the first time, we report that PDE8A exerts part of its control of T cell function through the V-raf-1 murine leukemia viral oncogene homolog 1 (Raf-1) kinase signaling pathway. To examine T cell motility under physiologic conditions, we analyzed T cell interactions with endothelial cells and ligands in flow assays. The highly PDE8-selective enzymatic inhibitor PF-04957325 suppresses adhesion of in vivo myelin oligodendrocyte glycoprotein (MOG) activated inflammatory CD4(+) T effector (Teff) cells to brain endothelial cells under shear stress. Recently, PDE8A was shown to associate with Raf-1 creating a compartment of low cAMP levels around Raf-1 thereby protecting it from protein kinase A (PKA) mediated inhibitory phosphorylation. To test the function of this complex in Teff cells, we used a cell permeable peptide that selectively disrupts the PDE8A-Raf-1 interaction. The disruptor peptide inhibits the Teff-endothelial cell interaction more potently than the enzymatic inhibitor. Furthermore, the LFA-1/ICAM-1 interaction was identified as a target of disruptor peptide mediated reduction of adhesion, spreading and locomotion of Teff cells under flow. Mechanistically, we observed that disruption of the PDE8A-Raf-1 complex profoundly alters Raf-1 signaling in Teff cells. Collectively, our studies demonstrate that PDE8A inhibition by enzymatic inhibitors or PDE8A-Raf-1 kinase complex disruptors decreases Teff cell adhesion and migration under flow, and represents a novel approach to target T cells in inflammation. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Blow-up estimates for semilinear parabolic systems coupled in an equation and a boundary condition

    Institute of Scientific and Technical Information of China (English)

    WANG; Mingxin(

    2001-01-01

    [1]Wang, S., Wang, M. X., Xie, C. H., Reaction-diffusion systems with nonlinear boundary conditions, Z. angew. Math.Phys., 1997, 48(6): 994-1001.[2]Fila, M., Quittner, P., The blow-up rate for a semilinear parabolic system, J. Math. Anal. Appl., 1999, 238: 468-476.[3]Hu, B., Remarks on the blow-up estimate for solutions of the heat equation with a nonlinear boundary condition, Differential Integral Equations, 1996, 9(5): 891-901.[4]Hu, B. , Yin, H. M., The profile near blow-up time for solution of the heat equation with a nonlinear boundary condition,Trans. of Amer. Math. Soc., 1994, 346: 117-135.[5]Amann, H., Parabolic equations and nonlinear boundary conditions, J. of Diff. Eqns., 1988, 72: 201-269.[6]Deng, K., Blow-up rates for parabolic systems, Z. angew. Math. Phys. ,1996, 47: 132-143.[7]Fila, M., Levine, H. A., On critical exponents for a semilinear parabolic system coupled in an equation and a boundary condition, J. Math. Anal. Appl., 1996, 204: 494-521.

  11. A priori estimates for global solutions and multiple equilibria of a superlinear parabolic problem involving measures

    Directory of Open Access Journals (Sweden)

    Pavol Quittner

    2001-05-01

    Full Text Available We consider a noncoercive elliptic problem in a bounded domain with a power nonlinearity and measure data. It is known that the problem possesses a stable solution and we prove existence of three further solutions. The proof is based on uniform bounds of global solutions of the corresponding parabolic problem and on a topological degree argument.

  12. Semilinear Parabolic Equations on the Heisenberg Group with a Singular Potential

    Directory of Open Access Journals (Sweden)

    Houda Mokrani

    2012-01-01

    Full Text Available We discuss the asymptotic behavior of solutions for semilinear parabolic equations on the Heisenberg group with a singular potential. The singularity is controlled by Hardy's inequality, and the nonlinearity is controlled by Sobolev's inequality. We also establish the existence of a global branch of the corresponding steady states via the classical Rabinowitz theorem.

  13. An abstract approximate controllability result and applications to elliptic and parabolic systems with dynamic boundary conditions

    Directory of Open Access Journals (Sweden)

    Ioan Bejenaru

    2001-07-01

    Full Text Available In this paper we prove an approximate controllability result for an abstract semilinear evolution equation in a Hilbert space and we obtain as consequences the approximate controllability for some classes of elliptic and parabolic problems subjected to nonlinear, possible non monotone, dynamic boundary conditions.

  14. ROS3P : an accurate third-order Rosenbrock solver designed for parabolic problems

    NARCIS (Netherlands)

    Lang, J.; Verwer, J.G.

    2000-01-01

    In this note we present a new Rosenbrock solver which is third--order accurate for nonlinear parabolic problems. Since Rosenbrock methods suffer from order reductions when they are applied to partial differential equations, additional order conditions have to be satisfied. Although these conditions

  15. On a Parabolic-Elliptic system with chemotaxis and logistic type growth

    Science.gov (United States)

    Galakhov, Evgeny; Salieva, Olga; Tello, J. Ignacio

    2016-10-01

    We consider a nonlinear PDEs system of two equations of Parabolic-Elliptic type with chemotactic terms. The system models the movement of a biological population "u" towards a higher concentration of a chemical agent "w" in a bounded and regular domain Ω ⊂RN for arbitrary N ∈ N. After normalization, the system is as follows

  16. Propagations of singularities in a parabolic system with coupling nonlocal sources

    Institute of Scientific and Technical Information of China (English)

    ZHANG He; KONG LingHua; ZHENG SiNing

    2009-01-01

    This paper deals with propagations of singularities in solutions to a parabolic system coupled with nonlocal nonlinear sources.The estimates for the four possible blow-up rates as well as the boundary layer profiles are established.The critical exponent of the system is determined also.

  17. Propagations of singularities in a parabolic system with coupling nonlocal sources

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    This paper deals with propagations of singularities in solutions to a parabolic system coupled with nonlocal nonlinear sources. The estimates for the four possible blow-up rates as well as the boundary layer profiles are established. The critical exponent of the system is determined also.

  18. Analyzing Parabolic Profile Path for Underwater Towed-Cable

    Institute of Scientific and Technical Information of China (English)

    Vineet KSrivastava

    2014-01-01

    This article discusses the dynamic state analysis of underwater towed-cable when tow-ship changes its speed in a direction making parabolic profile path. A three-dimensional model of underwater towed system is studied. The established governing equations for the system have been solved using the central implicit finite-difference method. The obtained difference non-linear coupled equations are solved by Newton’s method and satisfactory results were achieved. The solution of this problem has practical importance in the estimation of dynamic loading and motion, and hence it is directly applicable to the enhancement of safety and the effectiveness of the offshore activities.

  19. Upper bounds for parabolic equations and the Landau equation

    Science.gov (United States)

    Silvestre, Luis

    2017-02-01

    We consider a parabolic equation in nondivergence form, defined in the full space [ 0 , ∞) ×Rd, with a power nonlinearity as the right-hand side. We obtain an upper bound for the solution in terms of a weighted control in Lp. This upper bound is applied to the homogeneous Landau equation with moderately soft potentials. We obtain an estimate in L∞ (Rd) for the solution of the Landau equation, for positive time, which depends only on the mass, energy and entropy of the initial data.

  20. Deterministic homogenization of parabolic monotone operators with time dependent coefficients

    Directory of Open Access Journals (Sweden)

    Gabriel Nguetseng

    2004-06-01

    Full Text Available We study, beyond the classical periodic setting, the homogenization of linear and nonlinear parabolic differential equations associated with monotone operators. The usual periodicity hypothesis is here substituted by an abstract deterministic assumption characterized by a great relaxation of the time behaviour. Our main tool is the recent theory of homogenization structures by the first author, and our homogenization approach falls under the two-scale convergence method. Various concrete examples are worked out with a view to pointing out the wide scope of our approach and bringing the role of homogenization structures to light.

  1. Parabolic replicator dynamics and the principle of minimum Tsallis information gain.

    Science.gov (United States)

    Karev, Georgy P; Koonin, Eugene V

    2013-08-11

    Non-linear, parabolic (sub-exponential) and hyperbolic (super-exponential) models of prebiological evolution of molecular replicators have been proposed and extensively studied. The parabolic models appear to be the most realistic approximations of real-life replicator systems due primarily to product inhibition. Unlike the more traditional exponential models, the distribution of individual frequencies in an evolving parabolic population is not described by the Maximum Entropy (MaxEnt) Principle in its traditional form, whereby the distribution with the maximum Shannon entropy is chosen among all the distributions that are possible under the given constraints. We sought to identify a more general form of the MaxEnt principle that would be applicable to parabolic growth. We consider a model of a population that reproduces according to the parabolic growth law and show that the frequencies of individuals in the population minimize the Tsallis relative entropy (non-additive information gain) at each time moment. Next, we consider a model of a parabolically growing population that maintains a constant total size and provide an "implicit" solution for this system. We show that in this case, the frequencies of the individuals in the population also minimize the Tsallis information gain at each moment of the 'internal time" of the population. The results of this analysis show that the general MaxEnt principle is the underlying law for the evolution of a broad class of replicator systems including not only exponential but also parabolic and hyperbolic systems. The choice of the appropriate entropy (information) function depends on the growth dynamics of a particular class of systems. The Tsallis entropy is non-additive for independent subsystems, i.e. the information on the subsystems is insufficient to describe the system as a whole. In the context of prebiotic evolution, this "non-reductionist" nature of parabolic replicator systems might reflect the importance of group

  2. PDE-5 Inhibitors for BPH-Associated LUTS.

    Science.gov (United States)

    Brousil, Philip; Shabbir, Majid; Zacharakis, E; Sahai, Arun

    2015-01-01

    Lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH-LUTS) are a highly prevalent problem, and with considerable burden to quality of life. Evidence has emerged that a strong correlation exists in men suffering both BPH-LUTS and erectile dysfunction (ED). Phosphodiesterase type 5 inhibitors (PDE5i) have been shown to be highly effective in treating ED and more recently there is evidence that men with LUTS also benefit. In this review article we discuss the common pathogenic pathways of ED and LUTS, the scientific basis of PDE5i use, the efficacy of PDE5i in LUTS either as monotherapy or in combination with other established medications used in LUTS.

  3. Novel PDE4 inhibitors derived from Chinese medicine forsythia.

    Directory of Open Access Journals (Sweden)

    Tiffany A Coon

    Full Text Available Cyclic adenosine monophosphate (cAMP is a crucial intracellular second messenger molecule that converts extracellular molecules to intracellular signal transduction pathways generating cell- and stimulus-specific effects. Importantly, specific phosphodiesterase (PDE subtypes control the amplitude and duration of cAMP-induced physiological processes and are therefore a prominent pharmacological target currently used in a variety of fields. Here we tested the extracts from traditional Chinese medicine, Forsythia suspense seeds, which have been used for more than 2000 years to relieve respiratory symptoms. Using structural-functional analysis we found its major lignin, Forsynthin, acted as an immunosuppressant by inhibiting PDE4 in inflammatory and immune cell. Moreover, several novel, selective small molecule derivatives of Forsythin were tested in vitro and in murine models of viral and bacterial pneumonia, sepsis and cytokine-driven systemic inflammation. Thus, pharmacological targeting of PDE4 may be a promising strategy for immune-related disorders characterized by amplified host inflammatory response.

  4. Novel PDE4 Inhibitors Derived from Chinese Medicine Forsythia

    Science.gov (United States)

    Coon, Tiffany A.; McKelvey, Alison C.; Weathington, Nate M.; Birru, Rahel L.; Lear, Travis; Leikauf, George D.; Chen, Bill B.

    2014-01-01

    Cyclic adenosine monophosphate (cAMP) is a crucial intracellular second messenger molecule that converts extracellular molecules to intracellular signal transduction pathways generating cell- and stimulus-specific effects. Importantly, specific phosphodiesterase (PDE) subtypes control the amplitude and duration of cAMP-induced physiological processes and are therefore a prominent pharmacological target currently used in a variety of fields. Here we tested the extracts from traditional Chinese medicine, Forsythia suspense seeds, which have been used for more than 2000 years to relieve respiratory symptoms. Using structural-functional analysis we found its major lignin, Forsynthin, acted as an immunosuppressant by inhibiting PDE4 in inflammatory and immune cell. Moreover, several novel, selective small molecule derivatives of Forsythin were tested in vitro and in murine models of viral and bacterial pneumonia, sepsis and cytokine-driven systemic inflammation. Thus, pharmacological targeting of PDE4 may be a promising strategy for immune-related disorders characterized by amplified host inflammatory response. PMID:25549252

  5. Multiscale Reaction-Diffusion Algorithms: PDE-Assisted Brownian Dynamics

    KAUST Repository

    Franz, Benjamin

    2013-06-19

    Two algorithms that combine Brownian dynami cs (BD) simulations with mean-field partial differential equations (PDEs) are presented. This PDE-assisted Brownian dynamics (PBD) methodology provides exact particle tracking data in parts of the domain, whilst making use of a mean-field reaction-diffusion PDE description elsewhere. The first PBD algorithm couples BD simulations with PDEs by randomly creating new particles close to the interface, which partitions the domain, and by reincorporating particles into the continuum PDE-description when they cross the interface. The second PBD algorithm introduces an overlap region, where both descriptions exist in parallel. It is shown that the overlap region is required to accurately compute variances using PBD simulations. Advantages of both PBD approaches are discussed and illustrative numerical examples are presented. © 2013 Society for Industrial and Applied Mathematics.

  6. Multiscale reaction-diffusion algorithms: PDE-assisted Brownian dynamics

    CERN Document Server

    Franz, Benjamin; Chapman, S Jonathan; Erban, Radek

    2012-01-01

    Two algorithms that combine Brownian dynamics (BD) simulations with mean-field partial differential equations (PDEs) are presented. This PDE-assisted Brownian dynamics (PBD) methodology provides exact particle tracking data in parts of the domain, whilst making use of a mean-field reaction-diffusion PDE description elsewhere. The first PBD algorithm couples BD simulations with PDEs by randomly creating new particles close to the interface which partitions the domain and by reincorporating particles into the continuum PDE-description when they cross the interface. The second PBD algorithm introduces an overlap region, where both descriptions exist in parallel. It is shown that to accurately compute variances using the PBD simulation requires the overlap region. Advantages of both PBD approaches are discussed and illustrative numerical examples are presented.

  7. A Comparison of PETSC Library and HPF Implementations of an Archetypal PDE Computation

    Science.gov (United States)

    Hayder, M. Ehtesham; Keyes, David E.; Mehrotra, Piyush

    1997-01-01

    Two paradigms for distributed-memory parallel computation that free the application programmer from the details of message passing are compared for an archetypal structured scientific computation a nonlinear, structured-grid partial differential equation boundary value problem using the same algorithm on the same hardware. Both paradigms, parallel libraries represented by Argonne's PETSC, and parallel languages represented by the Portland Group's HPF, are found to be easy to use for this problem class, and both are reasonably effective in exploiting concurrency after a short learning curve. The level of involvement required by the application programmer under either paradigm includes specification of the data partitioning (corresponding to a geometrically simple decomposition of the domain of the PDE). Programming in SPAM style for the PETSC library requires writing the routines that discretize the PDE and its Jacobian, managing subdomain-to-processor mappings (affine global- to-local index mappings), and interfacing to library solver routines. Programming for HPF requires a complete sequential implementation of the same algorithm, introducing concurrency through subdomain blocking (an effort similar to the index mapping), and modest experimentation with rewriting loops to elucidate to the compiler the latent concurrency. Correctness and scalability are cross-validated on up to 32 nodes of an IBM SP2.

  8. Optimization with PDE constraints ESF networking program 'OPTPDE'

    CERN Document Server

    2014-01-01

    This book on PDE Constrained Optimization contains contributions on the mathematical analysis and numerical solution of constrained optimal control and optimization problems where a partial differential equation (PDE) or a system of PDEs appears as an essential part of the constraints. The appropriate treatment of such problems requires a fundamental understanding of the subtle interplay between optimization in function spaces and numerical discretization techniques and relies on advanced methodologies from the theory of PDEs and numerical analysis as well as scientific computing. The contributions reflect the work of the European Science Foundation Networking Programme ’Optimization with PDEs’ (OPTPDE).

  9. BOUNDARY ELEMENT APPROXIMATION OF THE SEMI-DISCRETE PARABOLIC VARIATIONAL INEQUALITIES OF THE SECOND KIND

    Institute of Scientific and Technical Information of China (English)

    Ding Rui; Jiang Meiqun; Peng Daping

    2005-01-01

    The boundary element approximation of the parabolic variational inequalities of the second kind is discussed. First, the parabolic variational inequalities of the second kind can be reduced to an elliptic variational inequality by using semidiscretization and implicit method in time; then the existence and uniqueness for the solution of nonlinear non-differentiable mixed variational inequality is discussed. Its corresponding mixed boundary variational inequality and the existence and uniqueness of its solution are yielded. This provides the theoretical basis for using boundary element method to solve the mixed variational inequality.

  10. Self-similar propagation and amplification of parabolic pulses in optical fibers.

    Science.gov (United States)

    Fermann, M E; Kruglov, V I; Thomsen, B C; Dudley, J M; Harvey, J D

    2000-06-26

    Ultrashort pulse propagation in high gain optical fiber amplifiers with normal dispersion is studied by self-similarity analysis of the nonlinear Schrödinger equation with gain. An exact asymptotic solution is found, corresponding to a linearly chirped parabolic pulse which propagates self-similarly subject to simple scaling rules. The solution has been confirmed by numerical simulations and experiments studying propagation in a Yb-doped fiber amplifier. Additional experiments show that the pulses remain parabolic after propagation through standard single mode fiber with normal dispersion.

  11. A multiplicity result for a class of quasilinear elliptic and parabolic problems

    Directory of Open Access Journals (Sweden)

    M. R. Grossinho

    1997-04-01

    Full Text Available We prove the existence of infinitely many solutions for a class of quasilinear elliptic and parabolic equations, subject respectively to Dirichlet and Dirichlet-periodic boundary conditions. We assume that the primitive of the nonlinearity at the right-hand side oscillates at infinity. The proof is based on the construction of upper and lower solutions, which are obtained as solutions of suitable comparison equations. This method allows the introduction of conditions on the potential for the study of parabolic problems, as well as to treat simultaneously the singular and the degenerate case.

  12. The nonlinear heat equation with state–dependent parameters and its connection to the Burgers’ and the potential Burgers’ equation

    DEFF Research Database (Denmark)

    Backi, Christoph Josef; Bendtsen, Jan Dimon; Leth, John-Josef

    2014-01-01

    In this work the stability properties of a nonlinear partial differential equation (PDE) with state–dependent parameters is investigated. Among other things, the PDE describes freezing of foodstuff, and is closely related to the (Potential) Burgers’ Equation. We show that for certain forms...

  13. Three-dimensional rogue waves in nonstationary parabolic potentials.

    Science.gov (United States)

    Yan, Zhenya; Konotop, V V; Akhmediev, N

    2010-09-01

    Using symmetry analysis we systematically present a higher-dimensional similarity transformation reducing the (3+1) -dimensional inhomogeneous nonlinear Schrödinger (NLS) equation with variable coefficients and parabolic potential to the (1+1) -dimensional NLS equation with constant coefficients. This transformation allows us to relate certain class of localized exact solutions of the (3+1) -dimensional case to the variety of solutions of integrable NLS equation of the (1+1) -dimensional case. As an example, we illustrated our technique using two lowest-order rational solutions of the NLS equation as seeding functions to obtain rogue wavelike solutions localized in three dimensions that have complicated evolution in time including interactions between two time-dependent rogue wave solutions. The obtained three-dimensional rogue wavelike solutions may raise the possibility of relative experiments and potential applications in nonlinear optics and Bose-Einstein condensates.

  14. Responsiveness to Exogenous Camp of a Saccharomyces Cerevisiae Strain Conferred by Naturally Occurring Alleles of Pde1 and Pde2

    OpenAIRE

    Mitsuzawa, H.

    1993-01-01

    The Saccharomyces cerevisiae strain P-28-24C, from which cAMP requiring mutants derived, responded to exogenously added cAMP. Upon the addition of cAMP, this strain showed phenotypes shared by mutants with elevated activity of the cAMP pathway. Genetic analysis involving serial crosses of this strain to a strain with another genetic background revealed that the responsiveness to cAMP results from naturally occurring loss-of-function alleles of PDE1 and PDE2, which encode low and high affinity...

  15. Acoustic shock wave propagation in a heterogeneous medium: a numerical simulation beyond the parabolic approximation.

    Science.gov (United States)

    Dagrau, Franck; Rénier, Mathieu; Marchiano, Régis; Coulouvrat, François

    2011-07-01

    Numerical simulation of nonlinear acoustics and shock waves in a weakly heterogeneous and lossless medium is considered. The wave equation is formulated so as to separate homogeneous diffraction, heterogeneous effects, and nonlinearities. A numerical method called heterogeneous one-way approximation for resolution of diffraction (HOWARD) is developed, that solves the homogeneous part of the equation in the spectral domain (both in time and space) through a one-way approximation neglecting backscattering. A second-order parabolic approximation is performed but only on the small, heterogeneous part. So the resulting equation is more precise than the usual standard or wide-angle parabolic approximation. It has the same dispersion equation as the exact wave equation for all forward propagating waves, including evanescent waves. Finally, nonlinear terms are treated through an analytical, shock-fitting method. Several validation tests are performed through comparisons with analytical solutions in the linear case and outputs of the standard or wide-angle parabolic approximation in the nonlinear case. Numerical convergence tests and physical analysis are finally performed in the fully heterogeneous and nonlinear case of shock wave focusing through an acoustical lens.

  16. A Generic High-performance GPU-based Library for PDE solvers

    DEFF Research Database (Denmark)

    Glimberg, Stefan Lemvig; Engsig-Karup, Allan Peter

    legacy codes are not always easily parallelized and the time spent on conversion might not pay o in the end. We present a highly generic C++ library for fast assembling of partial differential equation (PDE) solvers, aiming at utilizing the computational resources of GPUs. The library requires a minimum......, two important features for ecient GPU utilization and for enabling solution of large problems. In order to solve the large linear systems of equations, arising from the discretization of PDEs, the library includes a set of common iterative solvers. All iterative solvers are based on template arguments...... of fully nonlinear free surface water waves over uneven depths[1, 2, 3]. The wave model is based on the potential ow formulation, with the computational bottleneck of solving a fully three dimensional Laplace problem eciently. A robust h- or p-multigrid preconditioned defect correction method is applied...

  17. Modeling and Simulation of High Dimensional Stochastic Multiscale PDE Systems at the Exascale

    Energy Technology Data Exchange (ETDEWEB)

    Kevrekidis, Ioannis [Princeton Univ., NJ (United States)

    2017-03-22

    The thrust of the proposal was to exploit modern data-mining tools in a way that will create a systematic, computer-assisted approach to the representation of random media -- and also to the representation of the solutions of an array of important physicochemical processes that take place in/on such media. A parsimonious representation/parametrization of the random media links directly (via uncertainty quantification tools) to good sampling of the distribution of random media realizations. It also links directly to modern multiscale computational algorithms (like the equation-free approach that has been developed in our group) and plays a crucial role in accelerating the scientific computation of solutions of nonlinear PDE models (deterministic or stochastic) in such media – both solutions in particular realizations of the random media, and estimation of the statistics of the solutions over multiple realizations (e.g. expectations).

  18. Control of parabolic PDEs with time-varying spatial domain: Czochralski crystal growth process

    Science.gov (United States)

    Ng, James; Aksikas, Ilyasse; Dubljevic, Stevan

    2013-09-01

    This paper considers the optimal control problem for a class of convection-diffusion-reaction systems modelled by partial differential equations (PDEs) defined on time-varying spatial domains. The class of PDEs is characterised by the presence of a time-dependent convective-transport term which is associated with the time evolution of the spatial domain boundary. The functional analytic description of the PDE yields the representation of the initial and boundary value problem as a nonautonomous parabolic evolution equation on an appropriately defined infinite-dimensional function space. The properties of the time-varying evolution operator to guarantee existence and well posedness of the initial and boundary value problem are demonstrated which serves as the basis for the optimal control problem synthesis. An industrial application of the crystal temperature regulation problem for the Czochralski crystal growth process is considered and numerical simulation results are provided.

  19. Universal Structure and Universal PDE for Unitary Ensembles

    CERN Document Server

    Rumanov, Igor

    2009-01-01

    An attempt is made to describe random matrix ensembles with unitary invariance of measure (UE) in a unified way, using a combination of Tracy-Widom (TW) and Adler-Shiota-Van Moerbeke (ASvM) approaches to derivation of partial differential equations (PDE) for spectral gap probabilities. First, general 3-term recurrence relations for UE restricted to subsets of real line, or, in other words, for functions in the resolvent kernel, are obtained. Using them, simple universal relations between all TW dependent variables and one-dimensional Toda lattice $\\tau$-functions are found. A universal system of PDE for UE is derived from previous relations, which leads also to a {\\it single independent PDE} for spectral gap probability of various UE. Thus, orthogonal function bases and Toda lattice are seen at the core of correspondence of different approaches. Moreover, Toda-AKNS system provides a common structure of PDE for unitary ensembles. Interestingly, this structure can be seen in two very different forms: one arises...

  20. Phosphodiesterase 5 inhibitors (PDE5i) and pulmonary embolism

    NARCIS (Netherlands)

    Gerritsen, R.F.; Bijl, A.; Van Puijenbroek, E.P.

    2009-01-01

    Introduction: PDE5i-related arterial thromboembolism is described in literature. Published venous thrombotic events are limited to one case of pulmonary embolism (tadalafil) and of recurrent deep venous thrombosis (DVT) related to sildenafil. Aim of the study: Presentation of two cases of vardenafil

  1. Is PDE4 too difficult a drug target?

    Science.gov (United States)

    Higgs, Gerry

    2010-05-01

    The search for selective inhibitors of PDE4 as novel anti-inflammatory drugs has continued for more than 30 years. Although several compounds have demonstrated therapeutic effects in diseases such as asthma, COPD, atopic dermatitis and psoriasis, none have reached the market. A persistent challenge in the development of PDE4 inhibitors has been drug-induced gastrointestinal adverse effects, such as nausea. However, extensive clinical trials with well-tolerated doses of roflumilast (Daxas; Nycomed/Mitsubishi Tanabe Pharma Corp/Forest Laboratories Inc) in COPD, a disease that is generally unresponsive to existing therapies, have demonstrated significant therapeutic improvements. In addition, GlaxoSmithKline plc is developing 256066, an inhaled formulation of a PDE4 inhibitor that has demonstrated efficacy in trials in asthma, and apremilast from Celgene Corp has been reported to be effective for the treatment of psoriasis. Despite the challenges and complications that have been encountered during the development of PDE4 inhibitors, these drugs may provide a genuinely novel class of anti-inflammatory agents, and there are several compounds in development that could fulfill that promise.

  2. Numerical Solution of Parabolic Equations

    DEFF Research Database (Denmark)

    Østerby, Ole

    These lecture notes are designed for a one-semester course on finite-difference methods for parabolic equations. These equations which traditionally are used for describing diffusion and heat-conduction problems in Geology, Physics, and Chemistry have recently found applications in Finance Theory....... Among the special features of this book can be mentioned the presentation of a practical approach to reliable estimates of the global error, including warning signals if the reliability is questionable. The technique is generally applicable for estimating the discretization error in numerical...... approximations which depend on a step size, such as numerical integration and solution of ordinary and partial differential equations. An integral part of the error estimation is the estimation of the order of the method and can thus satisfy the inquisitive mind: Is the order what we expect it to be from theopry...

  3. Dynamic parabolic pulse generation using temporal shaping of wavelength to time mapped pulses.

    Science.gov (United States)

    Nguyen, Dat; Piracha, Mohammad Umar; Mandridis, Dimitrios; Delfyett, Peter J

    2011-06-20

    Self-phase modulation in fiber amplifiers can significantly degrade the quality of compressed pulses in chirped pulse amplification systems. Parabolic pulses with linear frequency chirp are suitable for suppressing nonlinearities, and to achieve high peak power pulses after compression. In this paper, we present an active time domain technique to generate parabolic pulses for chirped pulse amplification applications. Pulses from a mode-locked laser are temporally stretched and launched into an amplitude modulator, where the drive voltage is designed using the spectral shape of the input pulse and the transfer function of the modulator, resulting in the generation of parabolic pulses. Experimental results of pulse shaping with a pulse train from a mode-locked laser are presented, with a residual error of less than 5%. Moreover, an extinction ratio of 27 dB is achieved, which is ideal for chirped pulse amplification applications.

  4. Effect of Bend Loss on Parabolic Pulse Formation by Active Dispersion Tailored Fibers

    CERN Document Server

    Ghosh, Dipankar

    2009-01-01

    This work reports the performances of straight and bent active normal dispersion decreasing fibers (NDDF), with spatial nonlinear variation, to form parabolic self-similar pulses. The core radius changes along the NDDF length, thereby altering the transverse field distribution lengthwise. Hence bend loss is no longer a constant quantity. Including this loss variation, we investigate the performances of NDDFs as generators of parabolic self-similar pulses. In view of the small changes of relative refractive index differences during production, we obtain several NDDFs with variations of core radii. Suitable choice of index differences and bend radius of curvature of the fibers leads to obtain similaritons. Even for sufficiently small index differences and bend radii, parabolic pulses are formed at the cost of higher optimum length in comparison to straight fibers. The comparative study on the straight and bent NDDFs with different index difference values is helpful for fiber optic manufacturers to fabricate the...

  5. Analysis of the Quality of Parabolic Flight

    Science.gov (United States)

    Lambot, Thomas; Ord, Stephan F.

    2016-01-01

    Parabolic flights allow researchers to conduct several 20 second micro-gravity experiments in the course of a single day. However, the measurement can have large variations over the course of a single parabola, requiring the knowledge of the actual flight environment as a function of time. The NASA Flight Opportunities program (FO) reviewed the acceleration data of over 400 parabolic flights and investigated the quality of micro-gravity for scientific purposes. It was discovered that a parabolic flight can be segmented into multiple parts of different quality and duration, a fact to be aware of when planning an experiment.

  6. Quantum Fields, Stochastic PDE, and Reflection Positivity

    CERN Document Server

    Jaffe, Arthur

    2014-01-01

    We outline some known relations between classical random fields and quantum fields. In the scalar case, the existence of a quantum field is equivalent to the existence of a Euclidean-invariant, reflection-positive (RP) measure on the Schwartz space tempered distributions. Martin Hairer recently investigated random fields in a series of interesting papers, by studying non-linear stochastic partial differential equations, with a white noise driving term. To understand such stochastic quantization, we consider a linear example. We ask: does the measure on the solution induced by the stochastic driving term yield a quantum field? The RP property yields a general method to implement quantization. We show that the RP property fails for finite stochastic parameter $\\lambda$, although it holds in the limiting case $\\lambda=\\infty$.

  7. Self-similar evolutions of parabolic, Hermite-Gaussian, and hybrid optical pulses: Universality and diversity.

    Science.gov (United States)

    Chen, Shihua; Yi, Lin; Guo, Dong-Sheng; Lu, Peixiang

    2005-07-01

    Three novel types of self-similar solutions, termed parabolic, Hermite-Gaussian, and hybrid pulses, of the generalized nonlinear Schrödinger equation with varying dispersion, nonlinearity, and gain or absorption are obtained. The properties of the self-similar evolutions in various nonlinear media are confirmed by numerical simulations. Despite the diversity of their formations, these self-similar pulses exhibit many universal features which can facilitate significantly the achievement of well-defined linearly chirped output pulses from an optical fiber, an amplifier, or an absorption medium, under certain parametric conditions. The other intrinsic characteristics of each type of self-similar pulses are also discussed.

  8. PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER.

    Directory of Open Access Journals (Sweden)

    Amanda G Vang

    Full Text Available BACKGROUND: Abolishing the inhibitory signal of intracellular cAMP by phosphodiesterases (PDEs is a prerequisite for effector T (Teff cell function. While PDE4 plays a prominent role, its control of cAMP levels in Teff cells is not exclusive. T cell activation has been shown to induce PDE8, a PDE isoform with 40- to 100-fold greater affinity for cAMP than PDE4. Thus, we postulated that PDE8 is an important regulator of Teff cell functions. METHODOLOGY/PRINCIPAL FINDINGS: We found that Teff cells express PDE8 in vivo. Inhibition of PDE8 by the PDE inhibitor dipyridamole (DP activates cAMP signaling and suppresses two major integrins involved in Teff cell adhesion. Accordingly, DP as well as the novel PDE8-selective inhibitor PF-4957325-00 suppress firm attachment of Teff cells to endothelial cells. Analysis of downstream signaling shows that DP suppresses proliferation and cytokine expression of Teff cells from Crem-/- mice lacking the inducible cAMP early repressor (ICER. Importantly, endothelial cells also express PDE8. DP treatment decreases vascular adhesion molecule and chemokine expression, while upregulating the tight junction molecule claudin-5. In vivo, DP reduces CXCL12 gene expression as determined by in situ probing of the mouse microvasculature by cell-selective laser-capture microdissection. CONCLUSION/SIGNIFICANCE: Collectively, our data identify PDE8 as a novel target for suppression of Teff cell functions, including adhesion to endothelial cells.

  9. Reflective Properties of a Parabolic Mirror.

    Science.gov (United States)

    Ramsey, Gordon P.

    1991-01-01

    An incident light ray parallel to the optical axis of a parabolic mirror will be reflected at the focal point and vice versa. Presents a mathematical proof that uses calculus, algebra, and geometry to prove this reflective property. (MDH)

  10. POSITIVE EQUILIBRIUM SOLUTIONS OF SEMILINEAR PARABOLIC EQUATIONS

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The author studies semilinear parabolic equations with initial and periodic boundary value conditions. In the presence of non-well-ordered sub- and super-solutions:"subsolution (≤) supersolution", the existence and stability/instability of equilibrium solutions are obtained.

  11. Partial differential equations of parabolic type

    CERN Document Server

    Friedman, Avner

    2008-01-01

    This accessible and self-contained treatment provides even readers previously unacquainted with parabolic and elliptic equations with sufficient background to understand research literature. Author Avner Friedman - Director of the Mathematical Biosciences Institute at The Ohio State University - offers a systematic and thorough approach that begins with the main facts of the general theory of second order linear parabolic equations. Subsequent chapters explore asymptotic behavior of solutions, semi-linear equations and free boundary problems, and the extension of results concerning fundamenta

  12. Nonlocal Optical Spatial Soliton with a Non-parabolic Symmetry and Real-valued Convolution Response Kernel

    Institute of Scientific and Technical Information of China (English)

    LI Ke-Ping; YU Chao-Fan; GAO Zi-You; LIANG Guo-Dong; YU Xiao-Min

    2008-01-01

    Based on the picture of nonlinear and non-parabolic symmetry response, I.e., △n2( I) ≈ p(αo -α1x- α2x2), we propose a model for the transversal beam intensity distribution of the nonlocal spatial soliton. In this model, as a convolution response with non-parabolic symmetry, △n2( I) ≈ p(b0+b1 f - b2 f2 with b2/b1 > 0 is assumed. Furthermore, instead of the wave function Ψ, the high-order nonlinear equation for the beam intensity distribution f has been derived and the bell-shaped soliton solution with the envelope form has been obtained. The results demonstrate that, since the existence of the terms of non-parabolic response, the nonlocal spatial soliton has the bistable state solution. If thefrequency shift of wave number β satisfies 0 0 has been demonstrated.

  13. Nonlinear Peltier effect in semiconductors

    Science.gov (United States)

    Zebarjadi, Mona; Esfarjani, Keivan; Shakouri, Ali

    2007-09-01

    Nonlinear Peltier coefficient of a doped InGaAs semiconductor is calculated numerically using the Monte Carlo technique. The Peltier coefficient is also obtained analytically for single parabolic band semiconductors assuming a shifted Fermi-Dirac electronic distribution under an applied bias. Analytical results are in agreement with numerical simulations. Key material parameters affecting the nonlinear behavior are doping concentration, effective mass, and electron-phonon coupling. Current density thresholds at which nonlinear behavior is observable are extracted from numerical data. It is shown that the nonlinear Peltier effect can be used to enhance cooling of thin film microrefrigerator devices especially at low temperatures.

  14. On the design of experiments for determining ternary mixture free energies from static light scattering data using a nonlinear partial differential equation.

    Science.gov (United States)

    Wahle, Chris W; Ross, David S; Thurston, George M

    2012-07-21

    We mathematically design sets of static light scattering experiments to provide for model-independent measurements of ternary liquid mixing free energies to a desired level of accuracy. A parabolic partial differential equation (PDE), linearized from the full nonlinear PDE [D. Ross, G. Thurston, and C. Lutzer, J. Chem. Phys. 129, 064106 (2008)], describes how data noise affects the free energies to be inferred. The linearized PDE creates a net of spacelike characteristic curves and orthogonal, timelike curves in the composition triangle, and this net governs diffusion of information coming from light scattering measurements to the free energy. Free energy perturbations induced by a light scattering perturbation diffuse along the characteristic curves and towards their concave sides, with a diffusivity that is proportional to the local characteristic curvature radius. Consequently, static light scattering can determine mixing free energies in regions with convex characteristic curve boundaries, given suitable boundary data. The dielectric coefficient is a Lyapunov function for the dynamical system whose trajectories are PDE characteristics. Information diffusion is heterogeneous and system-dependent in the composition triangle, since the characteristics depend on molecular interactions and are tangent to liquid-liquid phase separation coexistence loci at critical points. We find scaling relations that link free energy accuracy, total measurement time, the number of samples, and the interpolation method, and identify the key quantitative tradeoffs between devoting time to measuring more samples, or fewer samples more accurately. For each total measurement time there are optimal sample numbers beyond which more will not improve free energy accuracy. We estimate the degree to which many-point interpolation and optimized measurement concentrations can improve accuracy and save time. For a modest light scattering setup, a sample calculation shows that less than two

  15. A General Symbolic PDE Solver Generator: Beyond Explicit Schemes

    Directory of Open Access Journals (Sweden)

    K. Sheshadri

    2003-01-01

    Full Text Available This paper presents an extension of our Mathematica- and MathCode-based symbolic-numeric framework for solving a variety of partial differential equation (PDE problems. The main features of our earlier work, which implemented explicit finite-difference schemes, include the ability to handle (1 arbitrary number of dependent variables, (2 arbitrary dimensionality, and (3 arbitrary geometry, as well as (4 developing finite-difference schemes to any desired order of approximation. In the present paper, extensions of this framework to implicit schemes and the method of lines are discussed. While C++ code is generated, using the MathCode system for the implicit method, Modelica code is generated for the method of lines. The latter provides a preliminary PDE support for the Modelica language. Examples illustrating the various aspects of the solver generator are presented.

  16. Modal reduction of PDE models by means of Snapshot Archetypes

    Science.gov (United States)

    Adrover, A.; Giona, M.

    2003-08-01

    A new method for constructing low-dimensional reduced models of dissipative partial differential equations is proposed. The original PDE, ut= F( u), is projected onto a linear subspace spanned by the so-called Snapshot Archetypes, that are selected spatial profiles of u( x, t). The selection rule of the Snapshot Archetypes characterizes the method. Two different selection methods are proposed. We provide an “energetic” criterion for the minimum number of archetypes needed for an accurate approximation of the asymptotic dynamics. This approach is tested for several PDE systems such as the Kuramoto-Sivashinsky equation, the Arneodo-Elezgaray reaction-diffusion model, and the self-ignition dynamics of a coal stockpile. The latter two systems exhibit a rich bifurcative structure and are suitable for checking the robustness of the Snapshot Archetype reduced models with respect to parameter variations.

  17. Mesh Algorithms for PDE with Sieve I: Mesh Distribution

    CERN Document Server

    Knepley, Matthew G

    2009-01-01

    We have developed a new programming framework, called Sieve, to support parallel numerical PDE algorithms operating over distributed meshes. We have also developed a reference implementation of Sieve in C++ as a library of generic algorithms operating on distributed containers conforming to the Sieve interface. Sieve makes instances of the incidence relation, or \\emph{arrows}, the conceptual first-class objects represented in the containers. Further, generic algorithms acting on this arrow container are systematically used to provide natural geometric operations on the topology and also, through duality, on the data. Finally, coverings and duality are used to encode not only individual meshes, but all types of hierarchies underlying PDE data structures, including multigrid and mesh partitions. In order to demonstrate the usefulness of the framework, we show how the mesh partition data can be represented and manipulated using the same fundamental mechanisms used to represent meshes. We present the complete des...

  18. Biomedical images texture detail denoising based on PDE

    Science.gov (United States)

    Chen, Guan-nan; Pan, Jian-ji; Li, Chao; Chen, Rong; Lin, Ju-qiang; Yan, Kun-tao; Huang, Zu-fang

    2009-08-01

    Biomedical images denosing based on Partial Differential Equation are well-known for their good processing results. General denosing methods based on PDE can remove the noises of images with gentle changes and preserve more structure details of edges, but have a poor effectiveness on the denosing of biomedical images with many texture details. This paper attempts to make an overview of biomedical images texture detail denosing based on PDE. Subsequently, Three kinds of important image denosing schemes are introduced in this paper: one is image denosing based on the adaptive parameter estimation total variation model, which denosing the images based on region energy distribution; the second is using G norm on the perception scale, which provides a more intuitive understanding of this norm; the final is multi-scale denosing decomposition. The above methods involved can preserve more structures of biomedical images texture detail. Furthermore, this paper demonstrates the applications of those three methods. In the end, the future trend of biomedical images texture detail denosing Based on PDE is pointed out.

  19. XRF map identification problems based on a PDE electrodeposition model

    Science.gov (United States)

    Sgura, Ivonne; Bozzini, Benedetto

    2017-04-01

    In this paper we focus on the following map identification problem (MIP): given a morphochemical reaction–diffusion (RD) PDE system modeling an electrodepostion process, we look for a time t *, belonging to the transient dynamics and a set of parameters \\mathbf{p} , such that the PDE solution, for the morphology h≤ft(x,y,{{t}\\ast};\\mathbf{p}\\right) and for the chemistry θ ≤ft(x,y,{{t}\\ast};\\mathbf{p}\\right) approximates a given experimental map M *. Towards this aim, we introduce a numerical algorithm using singular value decomposition (SVD) and Frobenius norm to give a measure of error distance between experimental maps for h and θ and simulated solutions of the RD-PDE system on a fixed time integration interval. The technique proposed allows quantitative use of microspectroscopy images, such as XRF maps. Specifically, in this work we have modelled the morphology and manganese distributions of nanostructured components of innovative batteries and we have followed their changes resulting from ageing under operating conditions. The availability of quantitative information on space-time evolution of active materials in terms of model parameters will allow dramatic improvements in knowledge-based optimization of battery fabrication and operation.

  20. Mean field spin glasses treated with PDE techniques

    Science.gov (United States)

    Barra, Adriano; Del Ferraro, Gino; Tantari, Daniele

    2013-07-01

    Following an original idea of Guerra, in these notes we analyze the Sherrington-Kirkpatrick model from different perspectives, all sharing the underlying approach which consists in linking the resolution of the statistical mechanics of the model (e.g. solving for the free energy) to well-known partial differential equation (PDE) problems (in suitable spaces). The plan is then to solve the related PDE using techniques involved in their native field and lastly bringing back the solution in the proper statistical mechanics framework. Within this strand, after a streamlined test-case on the Curie-Weiss model to highlight the methods more than the physics behind, we solve the SK both at the replica symmetric and at the 1-RSB level, obtaining the correct expression for the free energy via an analogy to a Fourier equation and for the self-consistencies with an analogy to a Burger equation, whose shock wave develops exactly at critical noise level (triggering the phase transition). Our approach, beyond acting as a new alternative method (with respect to the standard routes) for tackling the complexity of spin glasses, links symmetries in PDE theory with constraints in statistical mechanics and, as a novel result from the theoretical physics perspective, we obtain a new class of polynomial identities (namely of Aizenman-Contucci type, but merged within the Guerra's broken replica measures), whose interest lies in understanding, via the recent Panchenko breakthroughs, how to force the overlap organization to the ultrametric tree predicted by Parisi.

  1. Approximation error in PDE-based modelling of vehicular platoons

    Science.gov (United States)

    Hao, He; Barooah, Prabir

    2012-08-01

    We study the problem of how much error is introduced in approximating the dynamics of a large vehicular platoon by using a partial differential equation, as was done in Barooah, Mehta, and Hespanha [Barooah, P., Mehta, P.G., and Hespanha, J.P. (2009), 'Mistuning-based Decentralised Control of Vehicular Platoons for Improved Closed Loop Stability', IEEE Transactions on Automatic Control, 54, 2100-2113], Hao, Barooah, and Mehta [Hao, H., Barooah, P., and Mehta, P.G. (2011), 'Stability Margin Scaling Laws of Distributed Formation Control as a Function of Network Structure', IEEE Transactions on Automatic Control, 56, 923-929]. In particular, we examine the difference between the stability margins of the coupled-ordinary differential equations (ODE) model and its partial differential equation (PDE) approximation, which we call the approximation error. The stability margin is defined as the absolute value of the real part of the least stable pole. The PDE model has proved useful in the design of distributed control schemes (Barooah et al. 2009; Hao et al. 2011); it provides insight into the effect of gains of local controllers on the closed-loop stability margin that is lacking in the coupled-ODE model. Here we show that the ratio of the approximation error to the stability margin is O(1/N), where N is the number of vehicles. Thus, the PDE model is an accurate approximation of the coupled-ODE model when N is large. Numerical computations are provided to corroborate the analysis.

  2. Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy

    Science.gov (United States)

    Diggle, Christine P.; Sukoff Rizzo, Stacey J.; Popiolek, Michael; Hinttala, Reetta; Schülke, Jan-Philip; Kurian, Manju A.; Carr, Ian M.; Markham, Alexander F.; Bonthron, David T.; Watson, Christopher; Sharif, Saghira Malik; Reinhart, Veronica; James, Larry C.; Vanase-Frawley, Michelle A.; Charych, Erik; Allen, Melanie; Harms, John; Schmidt, Christopher J.; Ng, Joanne; Pysden, Karen; Strick, Christine; Vieira, Päivi; Mankinen, Katariina; Kokkonen, Hannaleena; Kallioinen, Matti; Sormunen, Raija; Rinne, Juha O.; Johansson, Jarkko; Alakurtti, Kati; Huilaja, Laura; Hurskainen, Tiina; Tasanen, Kaisa; Anttila, Eija; Marques, Tiago Reis; Howes, Oliver; Politis, Marius; Fahiminiya, Somayyeh; Nguyen, Khanh Q.; Majewski, Jacek; Uusimaa, Johanna; Sheridan, Eamonn; Brandon, Nicholas J.

    2016-01-01

    Deficits in the basal ganglia pathways modulating cortical motor activity underlie both Parkinson disease (PD) and Huntington disease (HD). Phosphodiesterase 10A (PDE10A) is enriched in the striatum, and animal data suggest that it is a key regulator of this circuitry. Here, we report on germline PDE10A mutations in eight individuals from two families affected by a hyperkinetic movement disorder due to homozygous mutations c.320A>G (p.Tyr107Cys) and c.346G>C (p.Ala116Pro). Both mutations lead to a reduction in PDE10A levels in recombinant cellular systems, and critically, positron-emission-tomography (PET) studies with a specific PDE10A ligand confirmed that the p.Tyr107Cys variant also reduced striatal PDE10A levels in one of the affected individuals. A knock-in mouse model carrying the homologous p.Tyr97Cys variant had decreased striatal PDE10A and also displayed motor abnormalities. Striatal preparations from this animal had an impaired capacity to degrade cyclic adenosine monophosphate (cAMP) and a blunted pharmacological response to PDE10A inhibitors. These observations highlight the critical role of PDE10A in motor control across species. PMID:27058446

  3. 10D massive type IIA supergravities as the uplift of parabolic M2-brane torus bundles

    Energy Technology Data Exchange (ETDEWEB)

    Garcia del Moral, Maria Pilar [Universidad de Antofagasta (Chile). Dept. de Fisica; Restuccia, Alvaro [Universidad de Antofagasta (Chile). Dept. de Fisica; Universidad Simon Bolivar, Caracas (Venezuela, Bolivarian Republic of). Dept. de Fisica

    2016-04-15

    We remark that the two 10D massive deformations of the N = 2 maximal type IIA supergravity (Romans and HLW supergravity) are associated to the low energy limit of the uplift to 10D of M2-brane torus bundles with parabolic monodromy linearly and non-linearly realized respectively. Romans supergravity corresponds to M2-brane compactified on a twice-punctured torus bundle. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  4. Obstacle problem for a class of parabolic equations of generalized p-Laplacian type

    Science.gov (United States)

    Lindfors, Casimir

    2016-11-01

    We study nonlinear parabolic PDEs with Orlicz-type growth conditions. The main result gives the existence of a unique solution to the obstacle problem related to these equations. To achieve this we show the boundedness of weak solutions and that a uniformly bounded sequence of weak supersolutions converges to a weak supersolution. Moreover, we prove that if the obstacle is continuous, so is the solution.

  5. Leptin receptor expressing neurons express phosphodiesterase-3B (PDE3B) and leptin induces STAT3 activation in PDE3B neurons in the mouse hypothalamus.

    Science.gov (United States)

    Sahu, Maitrayee; Sahu, Abhiram

    2015-11-01

    Leptin signaling in the hypothalamus is critical for normal food intake and body weight regulation. Cumulative evidence suggests that besides the signal transducer and activator of transcription-3 (STAT3) pathway, several non-STAT3 pathways including the phosphodiesterase-3B (PDE3B) pathway mediate leptin signaling in the hypothalamus. We have shown that PDE3B is localized in various hypothalamic sites implicated in the regulation of energy homeostasis and that the anorectic and body weight reducing effects of leptin are mediated by the activation of PDE3B. It is still unknown if PDE3B is expressed in the long form of the leptin-receptor (ObRb)-expressing neurons in the hypothalamus and whether leptin induces STAT3 activation in PDE3B-expressing neurons. In this study, we examined co-localization of PDE3B with ObRb neurons in various hypothalamic nuclei in ObRb-GFP mice that were treated with leptin (5mg/kg, ip) for 2h. Results showed that most of the ObRb neurons in the arcuate nucleus (ARC, 93%), ventromedial nucleus (VMN, 94%), dorsomedial nucleus (DMN, 95%), ventral premammillary nucleus (PMv, 97%) and lateral hypothalamus (LH, 97%) co-expressed PDE3B. We next examined co-localization of p-STAT3 and PDE3B in the hypothalamus in C57BL6 mice that were treated with leptin (5mg/kg, ip) for 1h. The results showed that almost all p-STAT3 positive neurons in different hypothalamic nuclei including ARC, VMN, DMN, LH and PMv areas expressed PDE3B. These results suggest the possibility for a direct role for the PDE3B pathway in mediating leptin action in the hypothalamus. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. Large mass self-similar solutions of the parabolic-parabolic Keller-Segel model of chemotaxis.

    Science.gov (United States)

    Biler, Piotr; Corrias, Lucilla; Dolbeault, Jean

    2011-07-01

    In two space dimensions, the parabolic-parabolic Keller-Segel system shares many properties with the parabolic-elliptic Keller-Segel system. In particular, solutions globally exist in both cases as long as their mass is less than a critical threshold M(c). However, this threshold is not as clear in the parabolic-parabolic case as it is in the parabolic-elliptic case, in which solutions with mass above M(c) always blow up. Here we study forward self-similar solutions of the parabolic-parabolic Keller-Segel system and prove that, in some cases, such solutions globally exist even if their total mass is above M(c), which is forbidden in the parabolic-elliptic case.

  7. Extinction and Positivity for a Doubly Nonlinear Degenerate Parabolic Equation

    Institute of Scientific and Technical Information of China (English)

    Hong Jun YUAN; Song Zhe LIAN; Chun Ling CAO; Wen Jie GAO; Xiao Jing XU

    2007-01-01

    The aims of this paper are to discuss the extinction and positivity for the solution of the initial boundary value problem and Cauchy problem of ut = div(|▽um]p-2▽um). It is proved that the weak solution will be extinct for 1<p≤+1/m and will be positive for p>1+1/m for large t, where m>0.

  8. Generic parabolic points are isolated in positive characteristic

    Science.gov (United States)

    Lindahl, Karl-Olof; Rivera-Letelier, Juan

    2016-05-01

    We study analytic germs in one variable with a parabolic fixed point at the origin, over an ultrametric ground field of positive characteristic. It is conjectured that for such a germ the origin is isolated as a periodic point. Our main result is an affirmative solution of this conjecture in the case of a generic germ with a prescribed multiplier. The genericity condition is explicit: the power series is minimally ramified, i.e. the degree of the first nonlinear term of each of its iterates is as small as possible. Our main technical result is a computation of the first significant terms of a minimally ramified power series. From this we obtain a lower bound for the norm of nonzero periodic points, from which we deduce our main result. As a by-product we give a new and self-contained proof of a characterization of minimally ramified power series in terms of the iterative residue.

  9. Darboux transformations and linear parabolic partial differential equations

    Energy Technology Data Exchange (ETDEWEB)

    Arrigo, Daniel J.; Hickling, Fred [Department of Mathematics, University of Central Arkansas, Conway, AR (United States)

    2002-07-19

    Solutions for a class of linear parabolic partial differential equation are provided. These solutions are obtained by first solving a system of (n+1) nonlinear partial differential equations. This system arises as the coefficients of a Darboux transformation and is equivalent to a matrix Burgers' equation. This matrix equation is solved using a generalized Hopf-Cole transformation. The solutions for the original equation are given in terms of solutions of the heat equation. These results are applied to the (1+1)-dimensional Schroedinger equation where all bound state solutions are obtained for a 2n-parameter family of potentials. As a special case, the solutions for integral members of the regular and modified Poeschl-Teller potentials are recovered. (author). Letter-to-the-editor.

  10. Piecewise-Planar Parabolic Reflectarray Antenna

    Science.gov (United States)

    Hodges, Richard; Zawadzki, Mark

    2009-01-01

    The figure shows a dual-beam, dualpolarization Ku-band antenna, the reflector of which comprises an assembly of small reflectarrays arranged in a piecewise- planar approximation of a parabolic reflector surface. The specific antenna design is intended to satisfy requirements for a wide-swath spaceborne radar altimeter, but the general principle of piecewise-planar reflectarray approximation of a parabolic reflector also offers advantages for other applications in which there are requirements for wideswath antennas that can be stowed compactly and that perform equally in both horizontal and vertical polarizations. The main advantages of using flat (e.g., reflectarray) antenna surfaces instead of paraboloidal or parabolic surfaces is that the flat ones can be fabricated at lower cost and can be stowed and deployed more easily. Heretofore, reflectarray antennas have typically been designed to reside on single planar surfaces and to emulate the focusing properties of, variously, paraboloidal (dish) or parabolic antennas. In the present case, one approximates the nominal parabolic shape by concatenating several flat pieces, while still exploiting the principles of the planar reflectarray for each piece. Prior to the conception of the present design, the use of a single large reflectarray was considered, but then abandoned when it was found that the directional and gain properties of the antenna would be noticeably different for the horizontal and vertical polarizations.

  11. Parabolic flight as a spaceflight analog.

    Science.gov (United States)

    Shelhamer, Mark

    2016-06-15

    Ground-based analog facilities have had wide use in mimicking some of the features of spaceflight in a more-controlled and less-expensive manner. One such analog is parabolic flight, in which an aircraft flies repeated parabolic trajectories that provide short-duration periods of free fall (0 g) alternating with high-g pullout or recovery phases. Parabolic flight is unique in being able to provide true 0 g in a ground-based facility. Accordingly, it lends itself well to the investigation of specific areas of human spaceflight that can benefit from this capability, which predominantly includes neurovestibular effects, but also others such as human factors, locomotion, and medical procedures. Applications to research in artificial gravity and to effects likely to occur in upcoming commercial suborbital flights are also possible. Copyright © 2016 the American Physiological Society.

  12. William Harvey Research Conference on PDE inhibitors: drugs with an expanding range of therapeutic uses.

    Science.gov (United States)

    O'Donnell

    2000-03-01

    Presentations at the William Harvey Research Conference on PDE Inhibitors described the molecular biology, biochemical regulation. pharmacology, and therapeutic utility of inhibitors of cyclic nucleotide phosphodiesterases (PDEs). Most of the talks focused on PDE4 and PDE5. two members of the 11-member PDE family that have attracted much interest over the last several years. These enzymes have been shown to be targets for drugs with wide-ranging clinical utility, including treatment of inflammation, depression, and male erectile dysfunction. The continued investigation of PDEs and the development of potent and selective inhibitors should provide even more therapeutic agents in years to come.

  13. Parabolic non-diffracting beams: geometrical approach

    Science.gov (United States)

    Sosa-Sánchez, Citlalli Teresa; Silva-Ortigoza, Gilberto; Alejandro Juárez-Reyes, Salvador; de Jesús Cabrera-Rosas, Omar; Espíndola-Ramos, Ernesto; Julián-Macías, Israel; Ortega-Vidals, Paula

    2017-08-01

    The aim of this work is to present a geometrical characterization of parabolic non-diffracting beams. To this end, we compute the corresponding angular spectrum of the separable non-diffracting parabolic beams in order to determine the one-parameter family of solutions of the eikonal equation associated with this type of beam. Using this information, we compute the corresponding wavefronts and caustic, and find that qualitatively the caustic corresponds to the maximum of the intensity pattern and the wavefronts are deformations of conical surfaces.

  14. Asymptotical Properties for Parabolic Systems of Neutral Type

    Institute of Scientific and Technical Information of China (English)

    CUI Bao-tong; HAN Mao-an

    2005-01-01

    Asymptotical properties for the solutions of neutral parabolic systems with Robin boundary conditions were analyzed by using the inequality analysis. The oscillations problems for the neutral parabolic systems were considered and some oscillation criteria for the systems were established.

  15. The Parabolic Jet Structure in M87 as a Magnetohydrodynamic Nozzle

    CERN Document Server

    Nakamura, Masanori

    2013-01-01

    The structure and dynamics of the M87 jet from sub-milli-arcsec to arcsecond scales are continuously examined. We analysed the VLBA archival data taken at 43 and 86 GHz to measure the size of VLBI cores. Millimeter/sub-mm VLBI cores are considered as innermost jet emissions, which has been originally suggested by Blandford & K\\"onigl. Those components fairly follow an extrapolated parabolic streamline in our previous study so that the jet has a single power-law structure with nearly five orders of magnitude in the distance starting from the vicinity of the supermassive black hole (SMBH), less than 10 Schwarzschild radius ($r_{\\rm s}$). We further inspect the jet parabolic structure as a counterpart of the magnetohydrodynamic (MHD) nozzle in order to identify the property of a bulk acceleration. We interpret that the parabolic jet consists of Poynting-flux dominated flows, powered by large amplitude, nonlinear torsional Alfv\\'en waves. We examine the non-relativistic MHD nozzle equation in a parabolic shap...

  16. Global existence and uniqueness of classical solutions for a generalized quasilinear parabolic equation with application to a glioblastoma growth model.

    Science.gov (United States)

    Wen, Zijuan; Fan, Meng; Asiri, Asim M; Alzahrani, Ebraheem O; El-Dessoky, Mohamed M; Kuang, Yang

    2017-04-01

    This paper studies the global existence and uniqueness of classical solutions for a generalized quasilinear parabolic equation with appropriate initial and mixed boundary conditions. Under some practicable regularity criteria on diffusion item and nonlinearity, we establish the local existence and uniqueness of classical solutions based on a contraction mapping. This local solution can be continued for all positive time by employing the methods of energy estimates, Lp-theory, and Schauder estimate of linear parabolic equations. A straightforward application of global existence result of classical solutions to a density-dependent diffusion model of in vitro glioblastoma growth is also presented.

  17. Uniqueness and stability of solution for Cauchy problem of degenerate quasilinear parabolic equations

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    [1]Oleinik, O. A., Samokhin,V. N., Mathematical Models in Boundary Layer Theorem, Boca Raton; Chapman and Hall/CRC, 1999.[2]Volpert, A.I., Hudjaev, S.I., On the problem for quasilinear degenerate parabolic equations of second order(Russian), Mat. Sb., 1967, 3: 374-396.[3]Zhao, J., Uniqueness of solutions of quasilinear degenerate parabolic equations, Northeastern Math. J., 1985,1(2): 153-165.[4]Wu, Z., Yin, J., Some properties of functions in BVx and their applications to the uniqueness of solutions for degenerate quasilinear parabolic equations, Northeastern Math. J., 1989,5(4): 395-422.[5]Brezis, H., Crandall, M.G., Uniqueness of solutions of the initial value problem for ut- △ψ(u) = 0, J.Math. Pures et Appl., 1979, 58: 153-163.[6]Kruzkov, S.N., First order quasilinear equations in several independent varaiables, Math. USSR-Sb., 1970, 10:217-243.[7]Cockburn, B., Gripenberg, G., Continious dependence on the nonlinearities of solutions of degenerate parabolic equations, J. Diff. Equatiaons, 1999, 151: 231-251.[8]Volpert, A.I., BV space and quasilinear equations, Mat. Sb., 1967, 73: 255-302.[9]Volpert, A.I., Hudjave, S.I., Analysis of class of discontinuous functions and the equations of mathematical physics (Russian), Izda. Nauka Moskwa, 1975.[10]Evans, L.C., Weak convergence methods for nonlinear partial differential equations, Conference Board of the Mathematical Sciences, Regional Conferences Series in Mathematics Number 74, 1998.[11]Wu, Z., Zhao, J., Yin, J., et al., Nonlinear Diffusion Equations, Singapore: Word Scientific, 2001.

  18. Simulation of Stochastic Processes by Coupled ODE-PDE

    Science.gov (United States)

    Zak, Michail

    2008-01-01

    A document discusses the emergence of randomness in solutions of coupled, fully deterministic ODE-PDE (ordinary differential equations-partial differential equations) due to failure of the Lipschitz condition as a new phenomenon. It is possible to exploit the special properties of ordinary differential equations (represented by an arbitrarily chosen, dynamical system) coupled with the corresponding Liouville equations (used to describe the evolution of initial uncertainties in terms of joint probability distribution) in order to simulate stochastic processes with the proscribed probability distributions. The important advantage of the proposed approach is that the simulation does not require a random-number generator.

  19. Pyrazolopyridines as potent PDE4B inhibitors: 5-Heterocycle SAR

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, Charlotte J.; Ballantine, Stuart P.; Coe, Diane M.; Cook, Caroline M.; Delves, Christopher J.; Dowle, Mike D.; Edlin, Chris D.; Hamblin, J. Nicole; Holman, Stuart; Johnson, Martin R.; Jones, Paul S.; Keeling, Sue E.; Kranz, Michael; Lindvall, Mika; Lucas, Fiona S.; Neu, Margarete; Solanke, Yemisi E.; Somers, Don O.; Trivedi, Naimisha A.; Wiseman, Joanne O. (GSK)

    2012-05-03

    Following the discovery of 4-(substituted amino)-1-alkyl-pyrazolo[3,4-b]pyridine-5-carboxamides as potent and selective phosphodiesterase 4B inhibitors, [Hamblin, J. N.; Angell, T.; Ballentine, S., et al. Bioorg. Med. Chem. Lett.2008, 18, 4237] the SAR of the 5-position was investigated further. A range of substituted heterocycles showed good potencies against PDE4. Optimisation using X-ray crystallography and computational modelling led to the discovery of 16, with sub-nM inhibition of LPS-induced TNF-{alpha} production from isolated human peripheral blood mononuclear cells.

  20. Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2.

    Science.gov (United States)

    Nankervis, Jacob L; Feil, Susanne C; Hancock, Nancy C; Zheng, Zhaohua; Ng, Hooi-Ling; Morton, Craig J; Holien, Jessica K; Ho, Patricia W M; Frazzetto, Mark M; Jennings, Ian G; Manallack, David T; Martin, T John; Thompson, Philip E; Parker, Michael W

    2011-12-01

    PDE4 inhibitors have been identified as therapeutic targets for a variety of conditions, particularly inflammatory diseases. We have serendipitously identified a novel class of phosphodiesterase 4 (PDE4) inhibitor during a study to discover antagonists of the parathyroid hormone receptor. X-ray crystallographic studies of PDE4D2 complexed to four potent inhibitors reveal the atomic details of how they inhibit the enzyme and a notable contrast to another recently reported thiophene-based inhibitor. Copyright © 2011 Elsevier Ltd. All rights reserved.

  1. A NEWTON MULTIGRID METHOD FOR QUASILINEAR PARABOLIC EQUATIONS

    Institute of Scientific and Technical Information of China (English)

    YU Xijun

    2005-01-01

    A combination of the classical Newton Method and the multigrid method, i.e.,a Newton multigrid method is given for solving quasilinear parabolic equations discretized by finite elements. The convergence of the algorithm is obtained for only one step Newton iteration per level. The asymptotically computational cost for quasilinear parabolic problems is O(NNk) similar to multigrid method for linear parabolic problems.

  2. Nonlinear evolution operators and semigroups applications to partial differential equations

    CERN Document Server

    Pavel, Nicolae H

    1987-01-01

    This research monograph deals with nonlinear evolution operators and semigroups generated by dissipative (accretive), possibly multivalued operators, as well as with the application of this theory to partial differential equations. It shows that a large class of PDE's can be studied via the semigroup approach. This theory is not available otherwise in the self-contained form provided by these Notes and moreover a considerable part of the results, proofs and methods are not to be found in other books. The exponential formula of Crandall and Liggett, some simple estimates due to Kobayashi and others, the characterization of compact semigroups due to Brézis, the proof of a fundamental property due to Ursescu and the author and some applications to PDE are of particular interest. Assuming only basic knowledge of functional analysis, the book will be of interest to researchers and graduate students in nonlinear analysis and PDE, and to mathematical physicists.

  3. Chernoff's distribution and parabolic partial differential equations

    NARCIS (Netherlands)

    P. Groeneboom; S.P. Lalley; N.M. Temme (Nico)

    2013-01-01

    textabstractWe give an alternative route to the derivation of the distribution of the maximum and the location of the maximum of one-sided and two-sided Brownian motion with a negative parabolic drift, using the Feynman-Kac formula with stopping times. The derivation also uses an interesting

  4. Orbit Connections in a Parabolic Equation.

    Science.gov (United States)

    1983-04-01

    Departamento de Matematica , 13560, Slo Carlos, S.P. Brasil. This research has been supported in part by CAPES-qoordena~io de Aperfeiqoamento de Pessoal...de Nivel Superior , Brasilia, D.F., Brasil under contract Proc. #3056/78. 1k ORBIT CONNECTIONS IN A PARABOLIC EQUATION by Jack K. Hale and Arnaldo S

  5. Stokes' theorem, volume growth and parabolicity

    CERN Document Server

    Valtorta, Daniele

    2010-01-01

    We present some new Stokes'type theorems on complete non-compact manifolds that extend, in different directions, previous work by Gaffney and Karp and also the so called Kelvin-Nevanlinna-Royden criterion for (p-)parabolicity. Applications to comparison and uniqueness results involving the p-Laplacian are deduced.

  6. CONTINUOUS DEPENDENCE FOR A BACKWARD PARABOLIC PROBLEM

    Institute of Scientific and Technical Information of China (English)

    刘继军

    2003-01-01

    We consider a backward parabolic problem arising in the description of the behavior of the toroidal part of the magenetic field in a dynamo problem. In our backward time problem, the media parameters are spatial distributed and the boundary conditions are of the Robin type. For this ill-posed problem, we prove that the solution depends continuously on the initial-time geometry.

  7. Discontinuous mixed covolume methods for parabolic problems.

    Science.gov (United States)

    Zhu, Ailing; Jiang, Ziwen

    2014-01-01

    We present the semidiscrete and the backward Euler fully discrete discontinuous mixed covolume schemes for parabolic problems on triangular meshes. We give the error analysis of the discontinuous mixed covolume schemes and obtain optimal order error estimates in discontinuous H(div) and first-order error estimate in L(2).

  8. An Approximation of Ultra-Parabolic Equations

    Directory of Open Access Journals (Sweden)

    Allaberen Ashyralyev

    2012-01-01

    Full Text Available The first and second order of accuracy difference schemes for the approximate solution of the initial boundary value problem for ultra-parabolic equations are presented. Stability of these difference schemes is established. Theoretical results are supported by the result of numerical examples.

  9. ANISOTROPIC PARABOLIC EQUATIONS WITH MEASURE DATA

    Institute of Scientific and Technical Information of China (English)

    Li Fengquan; Zhao Huixiu

    2001-01-01

    In this paper, we prove the existence of solutions to anisotropic parabolic equations with right hand side term in the bounded Radon measure M(Q) and the initial condition in M(Ω) or in Lm space (with m "small").

  10. Chernoff's distribution and parabolic partial differential equations

    NARCIS (Netherlands)

    P. Groeneboom; S.P. Lalley; N.M. Temme (Nico)

    2013-01-01

    textabstractWe give an alternative route to the derivation of the distribution of the maximum and the location of the maximum of one-sided and two-sided Brownian motion with a negative parabolic drift, using the Feynman-Kac formula with stopping times. The derivation also uses an interesting relatio

  11. Highway traffic estimation of improved precision using the derivative-free nonlinear Kalman Filter

    Science.gov (United States)

    Rigatos, Gerasimos; Siano, Pierluigi; Zervos, Nikolaos; Melkikh, Alexey

    2015-12-01

    The paper proves that the PDE dynamic model of the highway traffic is a differentially flat one and by applying spatial discretization its shows that the model's transformation into an equivalent linear canonical state-space form is possible. For the latter representation of the traffic's dynamics, state estimation is performed with the use of the Derivative-free nonlinear Kalman Filter. The proposed filter consists of the Kalman Filter recursion applied on the transformed state-space model of the highway traffic. Moreover, it makes use of an inverse transformation, based again on differential flatness theory which enables to obtain estimates of the state variables of the initial nonlinear PDE model. By avoiding approximate linearizations and the truncation of nonlinear terms from the PDE model of the traffic's dynamics the proposed filtering methods outperforms, in terms of accuracy, other nonlinear estimators such as the Extended Kalman Filter. The article's theoretical findings are confirmed through simulation experiments.

  12. Mesh Algorithms for PDE with Sieve I: Mesh Distribution

    Directory of Open Access Journals (Sweden)

    Matthew G. Knepley

    2009-01-01

    Full Text Available We have developed a new programming framework, called Sieve, to support parallel numerical partial differential equation(s (PDE algorithms operating over distributed meshes. We have also developed a reference implementation of Sieve in C++ as a library of generic algorithms operating on distributed containers conforming to the Sieve interface. Sieve makes instances of the incidence relation, or arrows, the conceptual first-class objects represented in the containers. Further, generic algorithms acting on this arrow container are systematically used to provide natural geometric operations on the topology and also, through duality, on the data. Finally, coverings and duality are used to encode not only individual meshes, but all types of hierarchies underlying PDE data structures, including multigrid and mesh partitions. In order to demonstrate the usefulness of the framework, we show how the mesh partition data can be represented and manipulated using the same fundamental mechanisms used to represent meshes. We present the complete description of an algorithm to encode a mesh partition and then distribute a mesh, which is independent of the mesh dimension, element shape, or embedding. Moreover, data associated with the mesh can be similarly distributed with exactly the same algorithm. The use of a high level of abstraction within the Sieve leads to several benefits in terms of code reuse, simplicity, and extensibility. We discuss these benefits and compare our approach to other existing mesh libraries.

  13. Distinct patterns of compartmentalization and proteolytic stability of PDE6C mutants linked to achromatopsia.

    Science.gov (United States)

    Cheguru, Pallavi; Majumder, Anurima; Artemyev, Nikolai O

    2015-01-01

    Phosphodiesterase-6 (PDE6) is an essential effector enzyme in vertebrate photoreceptor cells. Mutations in rod and cone PDE6 cause recessive retinitis pigmentosa and achromatopsia, respectively. The mechanisms of missense PDE6 mutations underlying severe visual disorders are poorly understood. To probe these mechanisms, we expressed seven known missense mutants of cone PDE6C in rods of transgenic Xenopus laevis and examined their stability and compartmentalization. PDE6C proteins with mutations in the catalytic domain, H602L and E790K, displayed modestly reduced proteolytic stability, but they were properly targeted to the outer segment of photoreceptor cells. Mutations in the regulatory GAF domains, R104W, Y323N, and P391L led to a proteolytic degradation of the proteins involving a cleavage in the GAFb domain. Lastly, the R29W and M455V mutations residing outside the conserved PDE6 domains produced a pattern of subcellular compartmentalization different from that of PDE6C. Thus, our results suggest a spectrum of mechanisms of missense PDE6C mutations in achromatopsia including catalytic defects, protein mislocalization, or a specific sequence of proteolytic degradation. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. All the lowest order PDE for spectral gaps of Gaussian matrices

    CERN Document Server

    Rumanov, Igor

    2010-01-01

    Tracy-Widom (TW) equations for one-matrix unitary ensembles (UE) (equivalent to a particular case of Schlesinger equations for isomonodromic deformations) are rewritten in a general form which allows one to derive all the lowest order equations (PDE) for spectral gap probabilities of UE without intermediate higher-order PDE. This is demonstrated on the example of Gaussian ensemble (GUE) for which all the third order PDE for gap probabilities are obtained explicitly. Moreover, there is a {\\it second order} PDE for GUE probabilities in the case of more than one spectral endpoint. This approach allows to derive all PDE at once where possible, while in the method based on Hirota bilinear identities and Virasoro constraints starting with different bilinear identities leads to different subsets of the full set of equations.

  15. Distribution of PDE8A in the nervous system of the Sprague-Dawley rat

    DEFF Research Database (Denmark)

    Kruse, Lars Schack; Møller, Morten; Kruuse, Christina

    2011-01-01

    Phosphodiesterases (PDEs) are essential regulators of cyclic nucleotide signaling. Little is known of the distribution and function of the cyclic adenosine monophosphate (cAMP) hydrolyzing PDE8A family. Employing immunohistochemistry and Western blots this study maps the distribution of PDE8A...... in the brain of adult male Sprague-Dawley rats and in the trigeminal ganglion. PDE8A was confined to neuronal perikaryal cytoplasm and to processes extending from those perikarya. The neurons exhibiting PDE8A-immunoreactivity were widely distributed in the forebrain, brain stem, and cerebellum. Strongly...... immunoreactive neurons were located in the olfactory bulb, the septal area, zona incerta, and reticular nucleus of the thalamus. Less immunoreactivity was seen in the hippocampus and cerebral cortex. Intense staining was detected in both the substantia nigra and the sensory trigeminal nucleus. In cerebellum PDE8...

  16. The unconditional stable and convergent difference methods with intrinsic parallelism for quasilinear parabolic systems

    Institute of Scientific and Technical Information of China (English)

    ZHOU Yulin; YUAN Guangwei; SHEN Longjun

    2004-01-01

    A kind of the general finite difference schemes with intrinsicparallelism for the boundary value problem of the quasilinearparabolic system is studied without assuming heuristically thatthe original boundary value problem%for the quasilinear parabolic systemhas the unique smooth vector solution. By the method of a prioriestimation of the discrete solutions of the nonlinear differencesystems, and the interpolation formulas of the various norms ofthe discrete functions and the fixed-pointtechnique in finite dimensional Euclidean space, the existence anduniqueness of the discrete vector solutions of the nonlineardifference system with intrinsic parallelismare proved. Moreover the unconditional stability ofthe general finite difference schemes with intrinsic parallelismis justified in the sense of the continuous dependence of thediscrete vector solution of the difference schemes on the discretedata of the original problems in the discrete W(2,1)2 norms. Finally the convergence of the discrete vector solutions ofthe certain difference schemes with intrinsic parallelism to the unique generalized solution of the original quasilinear parabolic problem is proved.

  17. UNCONDITIONAL STABLE DIFFERENCE METHODS WITH INTRINSIC PARALLELISM FOR SEMILINEAR PARABOLIC SYSTEMS OF DIVERGENCE TYPE

    Institute of Scientific and Technical Information of China (English)

    ZHOU YULIN; SHEN LONGJUN; YUAN GUANGWEI

    2004-01-01

    The general finite difference schemes with intrinsic parallelism for the boundary value problem of the semilinear parabolic system of divergence type with bounded measurable coefficients is studied. By the approach of the discrete functional analysis,the existence and uniqueness of the discrete vector solutions of the nonlinear difference system with intrinsic parallelism are proved. Moreover the unconditional stability of the general difference schemes with intrinsic parallelism justified in the sense of the continuous dependence of the discrete vector solution of the difference schemes on the discrete initial data of the original problems in the discrete W(2,1)2(Q△) norms.Finally the convergence of the discrete vector solutions of the certain difference schemes with intrinsic parallelism to the unique generalized solution of the original semilinear parabolic problem is proved.

  18. Strong coupling and stimulated emission in single parabolic quantum well microcavity for terahertz cascade

    Energy Technology Data Exchange (ETDEWEB)

    Tzimis, A.; Savvidis, P. G. [Department of Materials Science and Technology, University of Crete, 71003 Heraklion, Crete (Greece); Institute of Electronic Structure and Laser, Foundation for Research and Technology - Hellas, 71110 Heraklion, Crete (Greece); Trifonov, A. V.; Ignatiev, I. V. [Spin Optics Laboratory, State University of Saint-Petersburg, 1 Ulianovskaya, 198504 St. Petersburg (Russian Federation); Christmann, G.; Tsintzos, S. I. [Institute of Electronic Structure and Laser, Foundation for Research and Technology - Hellas, 71110 Heraklion, Crete (Greece); Hatzopoulos, Z. [Institute of Electronic Structure and Laser, Foundation for Research and Technology - Hellas, 71110 Heraklion, Crete (Greece); Department of Physics, University of Crete, 71003 Heraklion, Crete (Greece); Kavokin, A. V. [Spin Optics Laboratory, State University of Saint-Petersburg, 1 Ulianovskaya, 198504 St. Petersburg (Russian Federation); School of Physics and Astronomy, University of Southampton, Southampton SO17 1BJ (United Kingdom)

    2015-09-07

    We report observation of strong light-matter coupling in an AlGaAs microcavity (MC) with an embedded single parabolic quantum well. The parabolic potential is achieved by varying aluminum concentration along the growth direction providing equally spaced energy levels, as confirmed by Brewster angle reflectivity from a reference sample without MC. It acts as an active region of the structure which potentially allows cascaded emission of terahertz (THz) light. Spectrally and time resolved pump-probe spectroscopy reveals characteristic quantum beats whose frequencies range from 0.9 to 4.5 THz, corresponding to energy separation between relevant excitonic levels. The structure exhibits strong stimulated nonlinear emission with simultaneous transition to weak coupling regime. The present study highlights the potential of such devices for creating cascaded relaxation of bosons, which could be utilized for THz emission.

  19. The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).

    Science.gov (United States)

    Xie, Moses; Blackman, Brigitte; Scheitrum, Colleen; Mika, Delphine; Blanchard, Elise; Lei, Tao; Conti, Marco; Richter, Wito

    2014-05-01

    PDE4s (type 4 cyclic nucleotide phosphodiesterases) are divided into long and short forms by the presence or absence of conserved N-terminal domains termed UCRs (upstream conserved regions). We have shown previously that PDE4D2, a short variant, is a monomer, whereas PDE4D3, a long variant, is a dimer. In the present study, we have determined the apparent molecular masses of various long and short PDE4 variants by size-exclusion chromatography and sucrose density-gradient centrifugation. Our results indicate that dimerization is a conserved property of all long PDE4 forms, whereas short forms are monomers. Dimerization is mediated by the UCR domains. Given their high sequence conservation, the UCR domains mediate not only homo-oligomerization, but also hetero-oligomerization of distinct PDE4 long forms as detected by co-immunoprecipitation assays and FRET microscopy. Endogenous PDE4 hetero-oligomers are, however, low in abundance compared with homo-dimers, revealing the presence of mechanisms that predispose PDE4s towards homo-oligomerization. Oligomerization is a prerequisite for the regulatory properties of the PDE4 long forms, such as their PKA (protein kinase A)-dependent activation, but is not necessary for PDE4 protein-protein interactions. As a result, individual PDE4 protomers may independently mediate protein-protein interactions, providing a mechanism whereby PDE4s contribute to the assembly of macromolecular signalling complexes.

  20. Decreased catalytic activity and altered activation properties of PDE6C mutants associated with autosomal recessive achromatopsia

    DEFF Research Database (Denmark)

    Grau, Tanja; Artemyev, Nikolai O; Rosenberg, Thomas

    2011-01-01

    characterization of six missense mutations applying the baculovirus system to express recombinant mutant and wildtype chimeric PDE6C/PDE5 proteins in Sf9 insect cells. Purified proteins were analyzed using Western blotting, phosphodiesterase (PDE) activity measurements as well as inhibition assays by zaprinast...

  1. Parabolic dish collectors - A solar option

    Science.gov (United States)

    Truscello, V. C.

    1981-01-01

    A description is given of several parabolic-dish high temperature solar thermal systems currently undergoing performance trials. A single parabolic dish has the potential for generating 20 to 30 kW of electricity with fluid temperatures from 300 to 1650 C. Each dish is a complete power-producing unit, and may function either independently or as part of a group of linked modules. The two dish designs under consideration are of 11 and 12 meter diameters, yielding receiver operating temperatures of 925 and 815 C, respectively. The receiver designs described include (1) an organic working fluid (toluene) Rankine cycle engine; (2) a Brayton open cycle unit incorporating a hybrid combustion chamber and nozzle and a shaft-coupled permanent magnet alternator; and (3) a modified Stirling cycle device originally designed for automotive use. Also considered are thermal buffer energy storage and thermochemical transport and storage.

  2. Who dares to join a parabolic flight?

    Science.gov (United States)

    Montag, Christian; Zander, Tina; Schneider, Stefan

    2016-12-01

    Parabolic flights represent an important tool in space research to investigate zero gravity on airplanes. Research on these flights often target psychological and biological processes in humans to investigate if and how we can adapt to this unique environment. This research is costly, hard to conduct and clearly heavily relies on humans participating in experiments in this (unnatural) situation. The present study investigated N =66 participants and N =66 matched control persons to study if participants in such experimental flights differ in terms of their personality traits from non-parabonauts. The main finding of this study demonstrates that parabonauts score significantly lower on harm avoidance, a trait closely linked to being anxious. As anxious humans differ from non-anxious humans in their biology, the present observations need to be taken into account when aiming at the generalizability of psychobiological research findings conducted in zero gravity on parabolic flights.

  3. Antiperiodic Problems for Nonautonomous Parabolic Evolution Equations

    Directory of Open Access Journals (Sweden)

    R. N. Wang

    2014-01-01

    Full Text Available This work focuses on the antiperiodic problem of nonautonomous semilinear parabolic evolution equation in the form u′(t=A(tu(t+f(t,u(t, t∈R, u(t+T=-u(t, t∈R, where (Att∈R (possibly unbounded, depending on time, is a family of closed and densely defined linear operators on a Banach space X. Upon making some suitable assumptions such as the Acquistapace and Terreni conditions and exponential dichotomy on (Att∈R, we obtain the existence results of antiperiodic mild solutions to such problem. The antiperiodic problem of nonautonomous semilinear parabolic evolution equation of neutral type is also considered. As sample of application, these results are applied to, at the end of the paper, an antiperiodic problem for partial differential equation, whose operators in the linear part generate an evolution family of exponential stability.

  4. Moving interfaces and quasilinear parabolic evolution equations

    CERN Document Server

    Prüss, Jan

    2016-01-01

    In this monograph, the authors develop a comprehensive approach for the mathematical analysis of a wide array of problems involving moving interfaces. It includes an in-depth study of abstract quasilinear parabolic evolution equations, elliptic and parabolic boundary value problems, transmission problems, one- and two-phase Stokes problems, and the equations of incompressible viscous one- and two-phase fluid flows. The theory of maximal regularity, an essential element, is also fully developed. The authors present a modern approach based on powerful tools in classical analysis, functional analysis, and vector-valued harmonic analysis. The theory is applied to problems in two-phase fluid dynamics and phase transitions, one-phase generalized Newtonian fluids, nematic liquid crystal flows, Maxwell-Stefan diffusion, and a variety of geometric evolution equations. The book also includes a discussion of the underlying physical and thermodynamic principles governing the equations of fluid flows and phase transitions...

  5. Mechatronic Prototype of Parabolic Solar Tracker.

    Science.gov (United States)

    Morón, Carlos; Díaz, Jorge Pablo; Ferrández, Daniel; Ramos, Mari Paz

    2016-06-15

    In the last 30 years numerous attempts have been made to improve the efficiency of the parabolic collectors in the electric power production, although most of the studies have focused on the industrial production of thermoelectric power. This research focuses on the application of this concentrating solar thermal power in the unexplored field of building construction. To that end, a mechatronic prototype of a hybrid paraboloidal and cylindrical-parabolic tracker based on the Arduido technology has been designed. The prototype is able to measure meteorological data autonomously in order to quantify the energy potential of any location. In this way, it is possible to reliably model real commercial equipment behavior before its deployment in buildings and single family houses.

  6. Mechatronic Prototype of Parabolic Solar Tracker

    Directory of Open Access Journals (Sweden)

    Carlos Morón

    2016-06-01

    Full Text Available In the last 30 years numerous attempts have been made to improve the efficiency of the parabolic collectors in the electric power production, although most of the studies have focused on the industrial production of thermoelectric power. This research focuses on the application of this concentrating solar thermal power in the unexplored field of building construction. To that end, a mechatronic prototype of a hybrid paraboloidal and cylindrical-parabolic tracker based on the Arduido technology has been designed. The prototype is able to measure meteorological data autonomously in order to quantify the energy potential of any location. In this way, it is possible to reliably model real commercial equipment behavior before its deployment in buildings and single family houses.

  7. Block-triangular preconditioners for PDE-constrained optimization

    KAUST Repository

    Rees, Tyrone

    2010-11-26

    In this paper we investigate the possibility of using a block-triangular preconditioner for saddle point problems arising in PDE-constrained optimization. In particular, we focus on a conjugate gradient-type method introduced by Bramble and Pasciak that uses self-adjointness of the preconditioned system in a non-standard inner product. We show when the Chebyshev semi-iteration is used as a preconditioner for the relevant matrix blocks involving the finite element mass matrix that the main drawback of the Bramble-Pasciak method-the appropriate scaling of the preconditioners-is easily overcome. We present an eigenvalue analysis for the block-triangular preconditioners that gives convergence bounds in the non-standard inner product and illustrates their competitiveness on a number of computed examples. Copyright © 2010 John Wiley & Sons, Ltd.

  8. A regularizing iterative ensemble Kalman method for PDE-constrained inverse problems

    Science.gov (United States)

    Iglesias, Marco A.

    2016-02-01

    We introduce a derivative-free computational framework for approximating solutions to nonlinear PDE-constrained inverse problems. The general aim is to merge ideas from iterative regularization with ensemble Kalman methods from Bayesian inference to develop a derivative-free stable method easy to implement in applications where the PDE (forward) model is only accessible as a black box (e.g. with commercial software). The proposed regularizing ensemble Kalman method can be derived as an approximation of the regularizing Levenberg-Marquardt (LM) scheme (Hanke 1997 Inverse Problems 13 79-95) in which the derivative of the forward operator and its adjoint are replaced with empirical covariances from an ensemble of elements from the admissible space of solutions. The resulting ensemble method consists of an update formula that is applied to each ensemble member and that has a regularization parameter selected in a similar fashion to the one in the LM scheme. Moreover, an early termination of the scheme is proposed according to a discrepancy principle-type of criterion. The proposed method can be also viewed as a regularizing version of standard Kalman approaches which are often unstable unless ad hoc fixes, such as covariance localization, are implemented. The aim of this paper is to provide a detailed numerical investigation of the regularizing and convergence properties of the proposed regularizing ensemble Kalman scheme; the proof of these properties is an open problem. By means of numerical experiments, we investigate the conditions under which the proposed method inherits the regularizing properties of the LM scheme of (Hanke 1997 Inverse Problems 13 79-95) and is thus stable and suitable for its application in problems where the computation of the Fréchet derivative is not computationally feasible. More concretely, we study the effect of ensemble size, number of measurements, selection of initial ensemble and tunable parameters on the performance of the method

  9. Nonlinear diffusion equations

    CERN Document Server

    Wu Zhuo Qun; Li Hui Lai; Zhao Jun Ning

    2001-01-01

    Nonlinear diffusion equations, an important class of parabolic equations, come from a variety of diffusion phenomena which appear widely in nature. They are suggested as mathematical models of physical problems in many fields, such as filtration, phase transition, biochemistry and dynamics of biological groups. In many cases, the equations possess degeneracy or singularity. The appearance of degeneracy or singularity makes the study more involved and challenging. Many new ideas and methods have been developed to overcome the special difficulties caused by the degeneracy and singularity, which

  10. Building a parabolic solar concentrator prototype

    Energy Technology Data Exchange (ETDEWEB)

    Escobar-Romero, J F M; Montiel, S Vazquez y; Granados-AgustIn, F; Rodriguez-Rivera, E; Martinez-Yanez, L [INAOE, Luis Enrique Erro 1, Tonantzintla, Pue., 72840 (Mexico); Cruz-Martinez, V M, E-mail: jfmescobar@yahoo.com [Universidad Tecnologica de la Mixteca, Camino a Acatilma Km 2.5, Huajuapan de Leon, Oax., 69000 (Mexico)

    2011-01-01

    In order to not further degrade the environment, people have been seeking to replace non-renewable natural resources such as fossil fuels by developing technologies that are based on renewable resources. An example of these technologies is solar energy. In this paper, we show the building and test of a solar parabolic concentrator as a prototype for the production of steam that can be coupled to a turbine to generate electricity or a steam engine in any particular industrial process.

  11. Parabolic cylinder functions of large order

    Science.gov (United States)

    Jones, D. S.

    2006-06-01

    The asymptotic behaviour of parabolic cylinder functions of large real order is considered. Various expansions in terms of elementary functions are derived. They hold uniformly for the variable in appropriate parts of the complex plane. Some of the expansions are doubly asymptotic with respect to the order and the complex variable which is an advantage for computational purposes. Error bounds are determined for the truncated versions of the asymptotic series.

  12. Study on a Cross Diffusion Parabolic System

    Institute of Scientific and Technical Information of China (English)

    Li Chen; Ling Hsiao; Gerald Warnecke

    2007-01-01

    This paper considers a kind of strongly coupled cross diffusion parabolic system, which can be used as the multi-dimensional Lyumkis energy transport model in semiconductor science. The global existence and large time behavior are obtained for smooth solution to the initial boundary value problem. When the initial data are a small perturbation of an isothermal stationary solution, the smooth solution of the problem under the insulating boundary condition, converges to that stationary solution exponentially fast as time goes to infinity.

  13. Parabolic resection for mitral valve repair.

    Science.gov (United States)

    Drake, Daniel H; Drake, Charles G; Recchia, Dino

    2010-02-01

    Parabolic resection, named for the shape of the cut edges of the excised tissue, expands on a common 'trick' used by experienced mitral surgeons to preserve tissue and increase the probability of successful repair. Our objective was to describe and clinically analyze this simple modification of conventional resection. Thirty-six patients with mitral regurgitation underwent valve repair using parabolic resection in combination with other techniques. Institution specific mitral data, Society of Thoracic Surgeons data and preoperative, post-cardiopulmonary bypass (PCPB) and postoperative echocardiography data were collected and analyzed. Preoperative echocardiography demonstrated mitral regurgitation ranging from moderate to severe. PCPB transesophageal echocardiography demonstrated no regurgitation or mild regurgitation in all patients. Thirty-day surgical mortality was 2.8%. Serial echocardiograms demonstrated excellent repair stability. One patient (2.9%) with rheumatic disease progressed to moderate regurgitation 33 months following surgery. Echocardiography on all others demonstrated no or mild regurgitation at a mean follow-up of 22.8+/-12.8 months. No patient required mitral reintervention. Longitudinal analysis demonstrated 80% freedom from cardiac death, reintervention and greater than moderate regurgitation at four years following repair. Parabolic resection is a simple technique that can be very useful during complex mitral reconstruction. Early and intermediate echocardiographic studies demonstrate excellent results.

  14. Simulation of parabolic reflectors for ultraviolet phototherapy

    Science.gov (United States)

    Grimes, David Robert

    2016-08-01

    Ultraviolet (UVR) phototherapy is widely used to treat an array of skin conditions, including psoriasis, eczema and vitiligo. For such interventions, a quantified dose is vital if the treatment is to be both biologically effective and to avoid the detrimental effects of over-dosing. As dose is absorbed at surface level, the orientation of patient site with respect to the UVR lamps modulates effective dose. Previous investigations have modelled this behaviour, and examined the impact of shaped anodized aluminium reflectors typically placed around lamps in phototherapy cabins. These mirrors are effective but tend to yield complex patterns of reflection around the cabin which can result in substantial dose inhomogeneity. There has been some speculation over whether using the reflective property of parabolic mirrors might improve dose delivery or homogeneity through the treatment cabin. In this work, the effects of parabolic mirrors are simulated and compared with standard shaped mirrors. Simulation results strongly suggest that parabolic reflectors reduce total irradiance relative to standard shaped reflectors, and have a negligible impact on dose homogeneity.

  15. Simulation of parabolic reflectors for ultraviolet phototherapy.

    Science.gov (United States)

    Robert Grimes, David

    2016-08-21

    Ultraviolet (UVR) phototherapy is widely used to treat an array of skin conditions, including psoriasis, eczema and vitiligo. For such interventions, a quantified dose is vital if the treatment is to be both biologically effective and to avoid the detrimental effects of over-dosing. As dose is absorbed at surface level, the orientation of patient site with respect to the UVR lamps modulates effective dose. Previous investigations have modelled this behaviour, and examined the impact of shaped anodized aluminium reflectors typically placed around lamps in phototherapy cabins. These mirrors are effective but tend to yield complex patterns of reflection around the cabin which can result in substantial dose inhomogeneity. There has been some speculation over whether using the reflective property of parabolic mirrors might improve dose delivery or homogeneity through the treatment cabin. In this work, the effects of parabolic mirrors are simulated and compared with standard shaped mirrors. Simulation results strongly suggest that parabolic reflectors reduce total irradiance relative to standard shaped reflectors, and have a negligible impact on dose homogeneity.

  16. Convergence acceleration for time-independent first-order PDE using optimal PNB-approximations

    Energy Technology Data Exchange (ETDEWEB)

    Holmgren, S.; Branden, H. [Uppsala Univ. (Sweden)

    1996-12-31

    We consider solving time-independent (steady-state) flow problems in 2D or 3D governed by hyperbolic or {open_quotes}almost hyperbolic{close_quotes} systems of partial differential equations (PDE). Examples of such PDE are the Euler and the Navier-Stokes equations. The PDE is discretized using a finite difference or finite volume scheme with arbitrary order of accuracy. If the matrix B describes the discretized differential operator and u denotes the approximate solution, the discrete problem is given by a large system of equations.

  17. Global existence and blow-up of solutions to a parabolic system with nonlocal sources and boundaries

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    This paper deals with a semi-linear parabolic system with nonlinear nonlocal sources and nonlocal boundaries.By using super-and sub-solution techniques,we first give the sufficient conditions that the classical solution exists globally and blows up in a finite time respectively,and then give the necessary and sufficient conditions that two components u and v blow up simultaneously.Finally,the uniform blow-up profiles in the interior are presented.

  18. Global existence and blow-up of solutions to a parabolic system with nonlocal sources and boundaries

    Institute of Scientific and Technical Information of China (English)

    Ling-hua KONG; Ming-xin WANG

    2007-01-01

    This paper deals with a semi-linear parabolic system with nonlinear nonlocal sources and nonlocal boundaries. By using super- and sub-solution techniques, we first give the sufficient conditions that the classical solution exists globally and blows up in a finite time respectively, and then give the necessary and sufficient conditions that two components u and v blow up simultaneously. Finally, the uniform blow-up profiles in the interior are presented.

  19. Soliton Solutions in Bose-Einstein Condensates with Time-Dependent Atomic Scattering Length in an Expulsive Parabolic Potential

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jie-Fang; YANG Qin

    2005-01-01

    @@ We present both the bright and dark solitons of Bose-Einstein condensates with a time-dependent atomic scattering length in an expulsive parabolic potential. As a discussed example, we select the experimental parameter,i.e. the Feshbach-managed nonlinear coefficient reading a(t) = g0 exp(λt), and obtain the results which can be recovered in the literature [Phys. Rev. Lett. 94 (2005) 050402].

  20. Measurement of Liquid Viscosities in Tapered or Parabolic Capillaries.

    Science.gov (United States)

    Ershov; Zorin; Starov

    1999-08-01

    The possibility of using tapered or parabolic capillaries for measurement of liquid viscosities is investigated both experimentally and theoretically. It is demonstrated that even small deviations in capillary radius from a constant value may substantially affect measurement results. Equations are derived which allow correct analysis of the measurement results in tapered or parabolic capillaries. The following cases are analyzed: a water imbibition into a tapered or parabolic capillary and displacement of one liquid by another immiscible liquid in tapered or parabolic capillaries. Two possibilities are considered: (a) the narrow end of the capillary as capillary inlet and (b) the wide end of the capillary as capillary inlet. Copyright 1999 Academic Press.

  1. Fast Multipole-Based Elliptic PDE Solver and Preconditioner

    KAUST Repository

    Ibeid, Huda

    2016-12-07

    Exascale systems are predicted to have approximately one billion cores, assuming Gigahertz cores. Limitations on affordable network topologies for distributed memory systems of such massive scale bring new challenges to the currently dominant parallel programing model. Currently, there are many efforts to evaluate the hardware and software bottlenecks of exascale designs. It is therefore of interest to model application performance and to understand what changes need to be made to ensure extrapolated scalability. Fast multipole methods (FMM) were originally developed for accelerating N-body problems for particle-based methods in astrophysics and molecular dynamics. FMM is more than an N-body solver, however. Recent efforts to view the FMM as an elliptic PDE solver have opened the possibility to use it as a preconditioner for even a broader range of applications. In this thesis, we (i) discuss the challenges for FMM on current parallel computers and future exascale architectures, with a focus on inter-node communication, and develop a performance model that considers the communication patterns of the FMM for spatially quasi-uniform distributions, (ii) employ this performance model to guide performance and scaling improvement of FMM for all-atom molecular dynamics simulations of uniformly distributed particles, and (iii) demonstrate that, beyond its traditional use as a solver in problems for which explicit free-space kernel representations are available, the FMM has applicability as a preconditioner in finite domain elliptic boundary value problems, by equipping it with boundary integral capability for satisfying conditions at finite boundaries and by wrapping it in a Krylov method for extensibility to more general operators. Compared with multilevel methods, FMM is capable of comparable algebraic convergence rates down to the truncation error of the discretized PDE, and it has superior multicore and distributed memory scalability properties on commodity

  2. PDE-5 Inhibitors in Scleroderma Raynaud Phenomenon and Digital Ulcers: Current Status of Clinical Trials

    Directory of Open Access Journals (Sweden)

    Ann J. Impens

    2011-01-01

    Full Text Available Systemic sclerosis- (SSc- related vasculopathy, as manifested by Raynaud's Phenomenon (RP and digital ulcers (DUs, is associated with significant impairment of the quality of life and morbidity. The current vasoactive approach for SSc-RP, although employing vasodilators, is entirely off-label. PDE-5 inhibitors improve peripheral circulation, are well tolerated, and are widely used for various forms of constrictive vasculopathies. This class of medications has become one of the first lines of treatment of SSc-RP and SSc-DUs among rheumatologists that routinely treat SSc patients. Due to the lack of robust randomized clinical trials of PDE-5 inhibitors in SSc-RP/DUs, the PDE-5 inhibitors have not been FDA approved for these particular indications, which constitutes a significant barrier to prescribing this category of drugs. This paper reviews the current state of evidence-based knowledge in SSc-related vasculopathy and the use of PDE-5 inhibitors.

  3. Rigorous mathematical investigation of a nonlinear anisotropic diffusion-based image restoration model

    Directory of Open Access Journals (Sweden)

    Tudor Barbu

    2014-06-01

    Full Text Available A nonlinear diffusion based image denoising technique is introduced in this paper. The proposed PDE denoising and restoration scheme is based on a novel diffusivity function that uses an automatically detected conductance parameter. A robust mathematical treatment is also provided for our anisotropic diffusion model. We demonstrate that edge-stopping function model is properly chosen, explaining the mathematical reasons behind it. Also, we perform a rigorous mathematical investigation on of the existence and uniqueness of the solution of our nonlinear diffusion equation. This PDE-based noise removal approach outperforms most diffusion-based methods, producing considerably better smoothing results and providing a much better edge preservation.

  4. Mathematical Analysis of a PDE System for Biological Network Formation

    KAUST Repository

    Haskovec, Jan

    2015-02-04

    Motivated by recent physics papers describing rules for natural network formation, we study an elliptic-parabolic system of partial differential equations proposed by Hu and Cai [13, 15]. The model describes the pressure field thanks to Darcy\\'s type equation and the dynamics of the conductance network under pressure force effects with a diffusion rate D >= 0 representing randomness in the material structure. We prove the existence of global weak solutions and of local mild solutions and study their long term behavior. It turns out that, by energy dissipation, steady states play a central role to understand the network formation capacity of the system. We show that for a large diffusion coefficient D, the zero steady state is stable, while network formation occurs for small values of D due to the instability of the zero steady state, and the borderline case D = 0 exhibits a large class of dynamically stable (in the linearized sense) steady states.

  5. Optimal Wentzell Boundary Control of Parabolic Equations

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Yousong, E-mail: yousong.luo@rmit.edu.au [RMIT University, School of Mathematical and Geospatial Sciences (Australia)

    2017-04-15

    This paper deals with a class of optimal control problems governed by an initial-boundary value problem of a parabolic equation. The case of semi-linear boundary control is studied where the control is applied to the system via the Wentzell boundary condition. The differentiability of the state variable with respect to the control is established and hence a necessary condition is derived for the optimal solution in the case of both unconstrained and constrained problems. The condition is also sufficient for the unconstrained convex problems. A second order condition is also derived.

  6. Linear Parabolic Maps on the Torus

    CERN Document Server

    Zyczkowski, K; Zyczkowski, Karol; Nishikawa, Takashi

    1999-01-01

    We investigate linear parabolic maps on the torus. In a generic case these maps are non-invertible and discontinuous. Although the metric entropy of these systems is equal to zero, their dynamics is non-trivial due to folding of the image of the unit square into the torus. We study the structure of the maximal invariant set, and in a generic case we prove the sensitive dependence on the initial conditions. We study the decay of correlations and the diffusion in the corresponding system on the plane. We also demonstrate how the rationality of the real numbers defining the map influences the dynamical properties of the system.

  7. Surface roughness estimation of a parabolic reflector

    CERN Document Server

    Casco, Nicolás A

    2010-01-01

    Random surface deviations in a reflector antenna reduce the aperture efficiency. This communication presents a method for estimating the mean surface deviation of a parabolic reflector from a set of measured points. The proposed method takes into account systematic measurement errors, such as the offset between the origin of reference frame and the vertex of the surface, and the misalignment between the surface rotation axis and the measurement axis. The results will be applied to perform corrections to the surface of one of the 30 m diameter radiotelescopes at the Instituto Argentino de Radioastronom\\'ia (IAR).

  8. Parabolic dunes in north-eastern Brazil

    CERN Document Server

    Duran, O; Bezerra, L J C; Herrmann, H J; Maia, L P

    2007-01-01

    In this work we present measurements of vegetation cover over parabolic dunes with different degree of activation along the north-eastern Brazilian coast. We are able to extend the local values of the vegetation cover density to the whole dune by correlating measurements with the gray-scale levels of a high resolution satellite image of the dune field. The empirical vegetation distribution is finally used to validate the results of a recent continuous model of dune motion coupling sand erosion and vegetation growth.

  9. Alignment method for parabolic trough solar concentrators

    Science.gov (United States)

    Diver, Richard B [Albuquerque, NM

    2010-02-23

    A Theoretical Overlay Photographic (TOP) alignment method uses the overlay of a theoretical projected image of a perfectly aligned concentrator on a photographic image of the concentrator to align the mirror facets of a parabolic trough solar concentrator. The alignment method is practical and straightforward, and inherently aligns the mirror facets to the receiver. When integrated with clinometer measurements for which gravity and mechanical drag effects have been accounted for and which are made in a manner and location consistent with the alignment method, all of the mirrors on a common drive can be aligned and optimized for any concentrator orientation.

  10. Computer-Aided Transformation of PDE Models: Languages, Representations, and a Calculus of Operations

    Science.gov (United States)

    2016-01-05

    Computer-aided transformation of PDE models: languages, representations, and a calculus of operations A domain-specific embedded language called...languages, representations, and a calculus of operations Report Title A domain-specific embedded language called ibvp was developed to model initial...Computer-aided transformation of PDE models: languages, representations, and a calculus of operations 1 Vision and background Physical and engineered systems

  11. Inertial Manifold and Large Deviations Approach to Reduced PDE Dynamics

    Science.gov (United States)

    Cardin, Franco; Favretti, Marco; Lovison, Alberto

    2017-09-01

    In this paper a certain type of reaction-diffusion equation—similar to the Allen-Cahn equation—is the starting point for setting up a genuine thermodynamic reduction i.e. involving a finite number of parameters or collective variables of the initial system. We firstly operate a finite Lyapunov-Schmidt reduction of the cited reaction-diffusion equation when reformulated as a variational problem. In this way we gain a finite-dimensional ODE description of the initial system which preserves the gradient structure of the original one and that is exact for the static case and only approximate for the dynamic case. Our main concern is how to deal with this approximate reduced description of the initial PDE. To start with, we note that our approximate reduced ODE is similar to the approximate inertial manifold introduced by Temam and coworkers for Navier-Stokes equations. As a second approach, we take into account the uncertainty (loss of information) introduced with the above mentioned approximate reduction by considering the stochastic version of the ODE. We study this reduced stochastic system using classical tools from large deviations, viscosity solutions and weak KAM Hamilton-Jacobi theory. In the last part we suggest a possible use of a result of our approach in the comprehensive treatment non equilibrium thermodynamics given by Macroscopic Fluctuation Theory.

  12. The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin.

    Science.gov (United States)

    DiPilato, Lisa M; Ahmad, Faiyaz; Harms, Matthew; Seale, Patrick; Manganiello, Vincent; Birnbaum, Morris J

    2015-08-01

    Inhibition of adipocyte lipolysis by insulin is important for whole-body energy homeostasis; its disruption has been implicated as contributing to the development of insulin resistance and type 2 diabetes mellitus. The main target of the antilipolytic action of insulin is believed to be phosphodiesterase 3B (PDE3B), whose phosphorylation by Akt leads to accelerated degradation of the prolipolytic second messenger cyclic AMP (cAMP). To test this hypothesis genetically, brown adipocytes lacking PDE3B were examined for their regulation of lipolysis. In Pde3b knockout (KO) adipocytes, insulin was unable to suppress β-adrenergic receptor-stimulated glycerol release. Reexpressing wild-type PDE3B in KO adipocytes fully rescued the action of insulin against lipolysis. Surprisingly, a mutant form of PDE3B that ablates the major Akt phosphorylation site, murine S273, also restored the ability of insulin to suppress lipolysis. Taken together, these data suggest that phosphorylation of PDE3B by Akt is not required for insulin to suppress adipocyte lipolysis. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  13. Zaprinast impairs spatial memory by increasing PDE5 expression in the rat hippocampus.

    Science.gov (United States)

    Giorgi, Mauro; Pompili, Assunta; Cardarelli, Silvia; Castelli, Valentina; Biagioni, Stefano; Sancesario, Giuseppe; Gasbarri, Antonella

    2015-02-01

    In this work, we report the effect of post-training intraperitoneal administration of zaprinast on rat memory retention in the Morris water maze task that revealed a significant memory impairment at the intermediate dose of 10mg/kg. Zaprinast is capable of inhibiting both striatal and hippocampal PDE activity but to a different extent which is probably due to the different PDE isoforms expressed in these areas. To assess the possible involvement of cyclic nucleotides in rat memory impairment, we compared the effects obtained 30 min after the zaprinast injection with respect to 24h after injection by measuring both cyclic nucleotide levels and PDE activity. As expected, 30 min after the zaprinast administration, we observed an increase of cyclic nucleotides, which returned to a basal level within 24h, with the exception of the hippocampal cGMP which was significantly decreased at the dose of 10mg/kg of zaprinast. This increase in the hippocampal region is the result of a cGMP-specific PDE5 induction, confirmed by sildenafil inhibition, in agreement with literature data that demonstrate transcriptional regulation of PDE5 by cAMP/cGMP intracellular levels. Our results highlight the possible rebound effect of PDE inhibitors.

  14. Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases

    Directory of Open Access Journals (Sweden)

    Vincent Lagente

    2005-03-01

    Full Text Available Phosphodiesterases (PDEs are responsible for the breakdown of intracellular cyclic nucleotides, from which PDE4 are the major cyclic AMP metabolizing isoenzymes found in inflammatory and immune cells. This generated greatest interest on PDE4 as a potential target to treat lung inflammatory diseases. For example, cigarette smoke-induced neutrophilia in BAL was dose and time dependently reduced by cilomilast. Beside the undesired side effects associated with the first generation of PDE4 inhibitors, the second generation of selective inhibitors such as cilomilast and roflumilast showed clinical efficacy in asthma and chronic obstrutive pulmonary diseases trials, thus re-enhancing the interest on these classes of compounds. However, the ability of PDE4 inhibitors to prevent or modulate the airway remodelling remains relatively unexplored. We demonstrated that selective PDE4 inhibitor RP 73-401 reduced matrix metalloproteinase (MMP-9 activity and TGF-beta1 release during LPS-induced lung injury in mice and that CI-1044 inhibited the production of MMP-1 and MMP-2 from human lung fibroblasts stimulated by pro-inflammatory cytokines. Since inflammatory diseases of the bronchial airways are associated with destruction of normal tissue structure, our data suggest a therapeutic benefit for PDE4 inhibitors in tissue remodelling associated with chronic lung diseases.

  15. Discovery of novel PDE10 inhibitors by a robust homogeneous screening assay

    Institute of Scientific and Technical Information of China (English)

    Qun-yi LI; Ming-kai XU; Gang LIU; Claus Tornby CHRISTOFFERSEN; Ming-wei WANG

    2013-01-01

    Aim:To develop a homogeneous assay for high-throughput screening (HTS) of inhibitors of phosphodiesterase 10 (PDE10).Methods:Purified human PDE10 enzyme derived from E coli,[3H]-cAMP and yttrium silicate microbeads were used to develop an HTS assay based on the scintillation proximity assay (SPA) technology.This method was applied to a large-scale screening campaign against a diverse compound library and subsequent confirmation studies.Preliminary structure-activity relationship (SAR) studies were initiated through limited structural modifications of the hits.Results:The IC50 value of the control compound (papaverine) assessed with the SPA approach was comparable and consistent with that reported in the literature.Signal to background (S/B) ratio and Z' factor of the assay system were evaluated to be 5.24 and 0.71,respectively.In an HTS campaign of 71 360 synthetic and natural compounds,67 hits displayed reproducible PDE10 inhibition,of which,8 were chosen as the scaffold for structural modifications and subsequent SAR analysis.Conclusion:The homogeneous PDE10 SPA assay is an efficient and robust tool to screen potential PDE10 inhibitors.Preliminary SAR studies suggest that potent PDE10 inhibitors could be identified and developed through this strategy.

  16. Using system theory and energy methods to prove existence of non-linear PDE's

    NARCIS (Netherlands)

    Zwart, Hans

    2015-01-01

    Consider a network with linear dynamics on the edges, and observation and control in the nodes. Assume that on the edges there is no damping, and so the dynamics can be described by an infinite-dimensional, port-Hamiltonian system. For general infinite-dimensional systems, the zero dynamics can be d

  17. Special solutions of the Riccati equation with applications to the Gross-Pitaevskii nonlinear PDE

    Directory of Open Access Journals (Sweden)

    Anas Al Bastami

    2010-05-01

    Full Text Available A method for finding solutions of the Riccati differential equation $y' = P(x + Q(xy + R(xy^2$ is introduced. Provided that certain relations exist between the coefficient $P(x$, $Q(x$ and $R(x$, the above equation can be solved in closed form. We determine the required relations and find the general solutions to the aforementioned equation. The method is then applied to the Riccati equation arising in the solution of the multidimensional Gross-Pitaevskii equation of Bose-Einstein condensates by the F-expansion and the balance principle techniques.

  18. PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain.

    Science.gov (United States)

    Hegde, Shweta; Ji, Hao; Oliver, David; Patel, Neema S; Poupore, Nicolas; Shtutman, Michael; Kelly, Michy P

    2016-10-29

    Despite the fact that appropriate social behaviors are vital to thriving in one's environment, little is understood of the molecular mechanisms controlling social behaviors or how social experience sculpts these signaling pathways. Here, we determine if Phosphodiesterase 11A (PDE11A), an enzyme that is enriched in the ventral hippocampal formation (VHIPP) and that breaks down cAMP and cGMP, regulates social behaviors. PDE11 wild-type (WT), heterozygous (HT), and knockout (KO) mice were tested in various social approach assays and gene expression differences were measured by RNA sequencing. The effect of social isolation on PDE11A4 compartmentalization and subsequent social interactions and social memory was also assessed. Deletion of PDE11A triggered age- and sex-dependent deficits in social approach in specific social contexts but not others. Mice appear to detect altered social behaviors of PDE11A KO mice, because C57BL/6J mice prefer to spend time with a sex-matched PDE11A WT vs. its KO littermate; whereas, a PDE11A KO prefers to spend time with a novel PDE11A KO vs. its WT littermate. Not only is PDE11A required for intact social interactions, we found that 1month of social isolation vs. group housing decreased PDE11A4 protein expression specifically within the membrane fraction of VHIPP. This isolation-induced decrease in PDE11A4 expression appears functional because social isolation impairs subsequent social approach behavior and social memory in a PDE11A genotype-dependent manner. Pathway analyses following RNA sequencing suggests PDE11A is a key regulator of the oxytocin pathway and membrane signaling, consistent with its pivotal role in regulating social behavior.

  19. Focusing parabolic guide for very small samples

    Energy Technology Data Exchange (ETDEWEB)

    Hils, T.; Boeni, P.; Stahn, J

    2004-07-15

    Modern materials can often only be grown in small quantities. Therefore, neutron-scattering experiments are difficult to perform due to the low signal. In order to increase the flux at the sample position, we have developed the concept of a small focusing guide tube with parabolically shaped walls that are coated with supermirror m=3. The major advantage of parabolic focusing is that the flux maximum occurs not at the exit of the tube. It occurs at the focal point that can be several centimeters away from the exit of the tube. We show that an intensity gain of 6 can easily be obtained. Simulations using the software package McStas demonstrate that gain factors up to more than 50 can be realised on a spot size of approximately 1.2 mm diameter. For PGAA we expect flux gains of up to three orders of magnitude if multiplexing is used. We show that elliptic ballistic guides lead to flux gains of more than 6.

  20. Focusing parabolic guide for very small samples

    Science.gov (United States)

    Hils, T.; Boeni, P.; Stahn, J.

    2004-07-01

    Modern materials can often only be grown in small quantities. Therefore, neutron-scattering experiments are difficult to perform due to the low signal. In order to increase the flux at the sample position, we have developed the concept of a small focusing guide tube with parabolically shaped walls that are coated with supermirror m=3. The major advantage of parabolic focusing is that the flux maximum occurs not at the exit of the tube. It occurs at the focal point that can be several centimeters away from the exit of the tube. We show that an intensity gain of 6 can easily be obtained. Simulations using the software package McStas demonstrate that gain factors up to more than 50 can be realised on a spot size of approximately 1.2 mm diameter. For PGAA we expect flux gains of up to three orders of magnitude if multiplexing is used. We show that elliptic ballistic guides lead to flux gains of more than 6.

  1. A nonlocal parabolic system with application to a thermoelastic problem

    Directory of Open Access Journals (Sweden)

    Y. Lin

    1999-01-01

    problem is first transformed into an equivalent nonlocal parabolic systems using a transformation, and then the existence and uniqueness of the solutions are demonstrated via the theoretical potential representation theory of the parabolic equations. Finally some realistic situations in the applications are discussed using the results obtained in this paper.

  2. Carleman Estimates for Parabolic Equations with Nonhomogeneous Boundary Conditions

    Institute of Scientific and Technical Information of China (English)

    Oleg Yu IMANUVILOV; Jean Pierre PUEL; Masahiro YAMAMOTO

    2009-01-01

    The authors prove a new Carleman estimate for general linear second order parabolic equation with nonhomogeneous boundary conditions.On the basis of this estimate,improved Carleman estimates for the Stokes system and for a system of parabolic equations with a penalty term are obtained.This system can be viewed as an approximation of the Stokes system.

  3. A numerical study of mixed parabolic-gradient systems

    NARCIS (Netherlands)

    Verwer, J.G.; Sommeijer, B.P.

    2000-01-01

    This paper is concerned with the numerical solution of parabolic equations coupled to gradient equations. The gradient equations are ordinary differential equations whose solutions define positions of particles in the spatial domain of the parabolic equations. The vector field of the gradient equati

  4. The parabolic equation method for outdoor sound propagation

    DEFF Research Database (Denmark)

    Arranz, Marta Galindo

    The parabolic equation method is a versatile tool for outdoor sound propagation. The present study has focused on the Cranck-Nicolson type Parabolic Equation method (CNPE). Three different applications of the CNPE method have been investigated. The first two applications study variations...

  5. STABILITY OF A PARABOLIC FIXED POINT OF REVERSIBLE MAPPINGS

    Institute of Scientific and Technical Information of China (English)

    LIUBIN; YOUJIANGONG

    1994-01-01

    KAM theorem of reversible system is used to provide a sufficient condition which guarantees the stability of a parabolic fixed point of reversible mappings, The main idea is to discuss when the parabolic fixed point is surrounded by closed invariant carves and thus exhibits stable behaviour.

  6. On the dynamics of a mixed parabolic-gradient system

    NARCIS (Netherlands)

    J.K. Krottje (Johannes)

    2002-01-01

    textabstractIn the current paper the dynamics of a mixed parabolic-gradient system is examined. Thesystem, which is a coupled system of parabolic equations and gradient equations, acts as a first model for the outgrowth of axons in a developing nervous system. For modeling considerations it is relev

  7. Manipulation of dielectric particles with nondiffracting parabolic beams.

    Science.gov (United States)

    Ortiz-Ambriz, Antonio; Gutiérrez-Vega, Julio C; Petrov, Dmitri

    2014-12-01

    The trapping and manipulation of microscopic particles embedded in the structure of nondiffracting parabolic beams is reported. The particles acquire orbital angular momentum and exhibit an open trajectory following the parabolic fringes of the beam. We observe an asymmetry in the terminal velocity of the particles caused by the counteracting gradient and scattering forces.

  8. Surface plasmon polariton beam focusing with parabolic nanoparticle chains

    DEFF Research Database (Denmark)

    Radko, Ilya P.; Bozhevolnyi, Sergey I.; Evlyukhin, Andrey B.

    2007-01-01

    We report on the focusing of surface plasmon polariton (SPP) beams with parabolic chains of gold nanoparticles fabricated on thin gold films. SPP focusing with different parabolic chains is investigated in the wavelength range of 700–860 nm, both experimentally and theoretically. Mapping of SPP...

  9. Polaron Energy and Effective Mass in Parabolic Quantum Wells

    Institute of Scientific and Technical Information of China (English)

    WANG Zhi-Ping; LIANG Xi-Xia

    2005-01-01

    @@ The energy and effective mass of a polaron in a parabolic quantum well are studied theoretically by using LLP-like transformations and a variational approach. Numerical results are presented for the polaron energy and effective mass in the GaAs/Al0.3Ga0.7As parabolic quantum well. The results show that the energy and the effective mass of the polaron both have their maxima in the finite parabolic quantum well but decrease monotonously in the infinite parabolic quantum well with the increasing well width. It is verified that the bulk longitudinal optical phonon mode approximation is an adequate formulation for the electron-phonon coupling in parabolic quantum well structures.

  10. Optical, Energetic and Exergetic Analyses of Parabolic Trough Collectors

    Institute of Scientific and Technical Information of China (English)

    (O)ZT(U)RK Murat; (C)(I)(C)EK BEZ(I)R Nalan; (O)ZEK Nuri

    2007-01-01

    Parabolic trough collectors generate thermal energy from solar energy. Especially, they are very convenient for applications in high temperature solar power systems. To determine the design parameters, parabolic trough collectors must be analysed with optical analysis. In addition, thermodynamics (energy and exergy) analysis in the development of an energy efficient system must be achieved. Solar radiation passes through Earth's atmosphere until it reaches on Earth's surface and is focused from the parabolic trough collector to the tube receiver with a transparent insulated envelope. All of them constitute a complex mechanism. We investigate the geometry of parabolic trough reflector and characteristics of solar radiation to the reflecting surface through Earth's atmosphere, and calculate the collecting total energy in the receiver. The parabolic trough collector,of which design parameters are given, is analysed in regard to the energy and exergy analysis considering the meteorological specification in May, June, July and August in Isparta/Turkey, and the results are presented.

  11. THE UNCONDITIONAL CONVERGENT DIFFERENCE METHODS WITH INTRINSIC PARALLELISM FOR QUASILINEAR PARABOLIC SYSTEMS WITH TWO DIMENSIONS

    Institute of Scientific and Technical Information of China (English)

    Longjun Shen; Guangwei Yuan

    2003-01-01

    In the present work we are going to solve the boundary value problem for the quasilinearparabolic systems of partial differential equations with two space dimensions by the finitedifference method with intrinsic parallelism. Some fundamental behaviors of general finitedifference schemes with intrinsic parallelism for the mentioned problems are studied. By themethod of a priori estimation of the discrete solutions of the nonlinear difference systems,and the interpolation formulas of the various norms of the discrete functions and the fixed-point technique in finite dimensional Euclidean space, the existence of the discrete vectorsolutions of the nonlinear difference system with intrinsic parallelism are proved. Moreoverthe convergence of the discrete vector solutions of these difference schemes to the uniquegeneralized solution of the original quasilinear parabolic problem is proved.

  12. A framework for the construction of preconditioners for systems of PDE

    Energy Technology Data Exchange (ETDEWEB)

    Holmgren, S.; Otto, K. [Uppsala Univ. (Sweden)

    1994-12-31

    The authors consider the solution of systems of partial differential equations (PDE) in 2D or 3D using preconditioned CG-like iterative methods. The PDE is discretized using a finite difference scheme with arbitrary order of accuracy. The arising sparse and highly structured system of equations is preconditioned using a discretization of a modified PDE, possibly exploiting a different discretization stencil. The preconditioner corresponds to a separable problem, and the discretization in one space direction is constructed so that the corresponding matrix is diagonalized by a unitary transformation. If this transformation is computable using a fast O(n log{sub 2} n) algorithm, the resulting preconditioner solve is of the same complexity. Also, since the preconditioner solves are based on a dimensional splitting, the intrinsic parallelism is good. Different choices of the unitary transformation are considered, e.g., the discrete Fourier transform, sine transform, and modified sine transform. The preconditioners fully exploit the structure of the original problem, and it is shown how to compute the parameters describing them subject to different optimality constraints. Some of these results recover results derived by e.g. R. Chan, T. Chan, and E. Tyrtyshnikov, but here they are stated in a {open_quotes}PDE context{close_quotes}. Numerical experiments where different preconditioners are exploited are presented. Primarily, high-order accurate discretizations for first-order PDE problems are studied, but also second-order derivatives are considered. The results indicate that utilizing preconditioners based on fast solvers for modified PDE problems yields good solution algorithms. These results extend previously derived theoretical and numerical results for second-order approximations for first-order PDE, exploiting preconditioners based on fast Fourier transforms.

  13. PDE 7 inhibitors: new potential drugs for the therapy of spinal cord injury.

    Directory of Open Access Journals (Sweden)

    Irene Paterniti

    Full Text Available BACKGROUND: Primary traumatic mechanical injury to the spinal cord (SCI causes the death of a number of neurons that to date can neither be recovered nor regenerated. During the last years our group has been involved in the design, synthesis and evaluation of PDE7 inhibitors as new innovative drugs for several neurological disorders. Our working hypothesis is based on two different facts. Firstly, neuroinflammation is modulated by cAMP levels, thus the key role for phosphodiesterases (PDEs, which hydrolyze cAMP, is undoubtedly demonstrated. On the other hand, PDE7 is expressed simultaneously on leukocytes and on the brain, highlighting the potential crucial role of PDE7 as drug target for neuroinflammation. METHODOLOGY/PRINCIPAL FINDINGS: Here we present two chemically diverse families of PDE7 inhibitors, designed using computational techniques such as virtual screening and neuronal networks. We report their biological profile and their efficacy in an experimental SCI model induced by the application of vascular clips (force of 24 g to the dura via a four-level T5-T8 laminectomy. We have selected two candidates, namely S14 and VP1.15, as PDE7 inhibitors. These compounds increase cAMP production both in macrophage and neuronal cell lines. Regarding drug-like properties, compounds were able to cross the blood brain barrier using parallel artificial membranes (PAMPA methodology. SCI in mice resulted in severe trauma characterized by edema, neutrophil infiltration, and production of a range of inflammatory mediators, tissue damage, and apoptosis. Treatment of the mice with S14 and VP1.15, two PDE7 inhibitors, significantly reduced the degree of spinal cord inflammation, tissue injury (histological score, and TNF-α, IL-6, COX-2 and iNOS expression. CONCLUSIONS/SIGNIFICANCE: All these data together led us to propose PDE7 inhibitors, and specifically S14 and VP1.15, as potential drug candidates to be further studied for the treatment of SCI.

  14. Continuum Modeling and Control of Large Nonuniform Wireless Networks via Nonlinear Partial Differential Equations

    Directory of Open Access Journals (Sweden)

    Yang Zhang

    2013-01-01

    Full Text Available We introduce a continuum modeling method to approximate a class of large wireless networks by nonlinear partial differential equations (PDEs. This method is based on the convergence of a sequence of underlying Markov chains of the network indexed by N, the number of nodes in the network. As N goes to infinity, the sequence converges to a continuum limit, which is the solution of a certain nonlinear PDE. We first describe PDE models for networks with uniformly located nodes and then generalize to networks with nonuniformly located, and possibly mobile, nodes. Based on the PDE models, we develop a method to control the transmissions in nonuniform networks so that the continuum limit is invariant under perturbations in node locations. This enables the networks to maintain stable global characteristics in the presence of varying node locations.

  15. Phosphodiesterase-5A (PDE5A) is localized to the endothelial caveolae and modulates NOS3 activity.

    Science.gov (United States)

    Gebska, Milena A; Stevenson, Blake K; Hemnes, Anna R; Bivalacqua, Trinity J; Haile, Azeb; Hesketh, Geoffrey G; Murray, Christopher I; Zaiman, Ari L; Halushka, Marc K; Krongkaew, Nispa; Strong, Travis D; Cooke, Carol A; El-Haddad, Hazim; Tuder, Rubin M; Berkowitz, Dan E; Champion, Hunter C

    2011-05-01

    It has been well demonstrated that phosphodiesterase-5A (PDE5A) is expressed in smooth muscle cells and plays an important role in regulation of vascular tone. The role of endothelial PDE5A, however, has not been yet characterized. The present study was undertaken to determine the presence, localization, and potential physiologic significance of PDE5A within vascular endothelial cells. We demonstrate primary location of human, mouse, and bovine endothelial PDE5A at or near caveolae. We found that the spatial localization of PDE5A at the level of caveolin-rich lipid rafts allows for a feedback loop between endothelial PDE5A and nitric oxide synthase (NOS3). Treatment of human endothelium with PDE5A inhibitors resulted in a significant increase in NOS3 activity, whereas overexpression of PDE5A using an adenoviral vector, both in vivo and in cell culture, resulted in decreased NOS3 activity and endothelium-dependent vasodilation. The molecular mechanism responsible for these interactions is primarily regulated by cGMP-dependent second messenger. PDE5A overexpression also resulted in a significant decrease in protein kinase 1 (PKG1) activity. Overexpression of PKG1 rapidly activated NOS3, whereas silencing of the PKG1 gene with siRNA inhibited both NOS3 phosphorylation (S1179) and activity, indicating a novel role for PKG1 in direct regulation of NOS3. Our data collectively suggest another target for PDE5A inhibition in endothelial dysfunction and provide another physiologic significance for PDE5A in the modulation of endothelial-dependent flow-mediated vasodilation. Using both in vitro and in vivo models, as well as human data, we show that inhibition of endothelial PDE5A improves endothelial function.

  16. Notes on a PDE system for biological network formation

    KAUST Repository

    Haskovec, Jan

    2016-01-22

    We present new analytical and numerical results for the elliptic–parabolic system of partial differential equations proposed by Hu and Cai, which models the formation of biological transport networks. The model describes the pressure field using a Darcy’s type equation and the dynamics of the conductance network under pressure force effects. Randomness in the material structure is represented by a linear diffusion term and conductance relaxation by an algebraic decay term. The analytical part extends the results of Haskovec et al. (2015) regarding the existence of weak and mild solutions to the whole range of meaningful relaxation exponents. Moreover, we prove finite time extinction or break-down of solutions in the spatially one-dimensional setting for certain ranges of the relaxation exponent. We also construct stationary solutions for the case of vanishing diffusion and critical value of the relaxation exponent, using a variational formulation and a penalty method. The analytical part is complemented by extensive numerical simulations. We propose a discretization based on mixed finite elements and study the qualitative properties of network structures for various parameter values. Furthermore, we indicate numerically that some analytical results proved for the spatially one-dimensional setting are likely to be valid also in several space dimensions.

  17. Parabolic refined invariants and Macdonald polynomials

    CERN Document Server

    Chuang, Wu-yen; Donagi, Ron; Pantev, Tony

    2013-01-01

    A string theoretic derivation is given for the conjecture of Hausel, Letellier, and Rodriguez-Villegas on the cohomology of character varieties with marked points. Their formula is identified with a refined BPS expansion in the stable pair theory of a local root stack, generalizing previous work of the first two authors in collaboration with G. Pan. Haiman's geometric construction for Macdonald polynomials is shown to emerge naturally in this context via geometric engineering. In particular this yields a new conjectural relation between Macdonald polynomials and refined local orbifold curve counting invariants. The string theoretic approach also leads to a new spectral cover construction for parabolic Higgs bundles in terms of holomorphic symplectic orbifolds.

  18. Antireflection Pyrex envelopes for parabolic solar collectors

    Science.gov (United States)

    McCollister, H. L.; Pettit, R. B.

    1983-11-01

    Antireflective (AR) coatings, applied to the glass envelopes used in parabolic trough solar collectors around the receiver tube in order to reduce thermal losses, can increase solar transmittance by 7 percent. An AR surface has been formed on Pyrex by first heat treating the glass to cause a compositional phase separation, removing a surface layer after heat treatment through the use of a preetching solution, and finally etching in a solution that contains hydrofluorosilic and ammonium bifluoride acids. AR-coated samples with solar transmittance values of more than 0.97, by comparison to an untreated sample value of 0.91, have been obtained for the 560-630 C range of heat treatment temperatures. Optimum values have also been determined for the other processing parameters.

  19. Photon-Atom Coupling with Parabolic Mirrors

    CERN Document Server

    Sondermann, Markus

    2014-01-01

    Efficient coupling of light to single atomic systems has gained considerable attention over the past decades. This development is driven by the continuous growth of quantum technologies. The efficient coupling of light and matter is an enabling technology for quantum information processing and quantum communication. And indeed, in recent years much progress has been made in this direction. But applications aside, the interaction of photons and atoms is a fundamental physics problem. There are various possibilities for making this interaction more efficient, among them the apparently 'natural' attempt of mode-matching the light field to the free-space emission pattern of the atomic system of interest. Here we will describe the necessary steps of implementing this mode-matching with the ultimate aim of reaching unit coupling efficiency. We describe the use of deep parabolic mirrors as the central optical element of a free-space coupling scheme, covering the preparation of suitable modes of the field incident on...

  20. Analysis of the Quality of Parabolic Flight

    Science.gov (United States)

    Lambot, Thomas; Ord, Stephan F.

    2016-01-01

    Parabolic flight allows researchers to conduct several micro-gravity experiments, each with up to 20 seconds of micro-gravity, in the course of a single day. However, the quality of the flight environment can vary greatly over the course of a single parabola, thus affecting the experimental results. Researchers therefore require knowledge of the actual flight environment as a function of time. The NASA Flight Opportunities program (FO) has reviewed the acceleration data for over 400 parabolas and investigated the level of micro-gravity quality. It was discovered that a typical parabola can be segmented into multiple phases with different qualities and durations. The knowledge of the microgravity characteristics within the parabola will prove useful when planning an experiment.

  1. New method to solve electromagnetic parabolic equation

    Institute of Scientific and Technical Information of China (English)

    赵小峰; 黄思训; 康林春

    2013-01-01

    This paper puts forward a new method to solve the electromagnetic parabolic equation (EMPE) by taking the vertically-layered inhomogeneous characteristics of the atmospheric refractive index into account. First, the Fourier transform and the convo-lution theorem are employed, and the second-order partial differential equation, i.e., the EMPE, in the height space is transformed into first-order constant coefficient differential equations in the frequency space. Then, by use of the lower triangular characteristics of the coefficient matrix, the numerical solutions are designed. Through constructing ana-lytical solutions to the EMPE, the feasibility of the new method is validated. Finally, the numerical solutions to the new method are compared with those of the commonly used split-step Fourier algorithm.

  2. Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects.

    Science.gov (United States)

    García, Ana M; Brea, José; González-García, Alejandro; Pérez, Concepción; Cadavid, María Isabel; Loza, María Isabel; Martinez, Ana; Gil, Carmen

    2017-09-04

    Phosphodiesterase (PDE) enzymes regulate the levels of cyclic nucleotides, cAMP, and/or cGMP, being attractive therapeutic targets. In order to modulate PDE activity in a selective way, we focused our efforts on the search of allosteric modulators. Based on the crystal structure of the PDE10A GAF-B domain, a virtual screening study allowed the discovery of new hits that were also tested experimentally, showing inhibitory activities in the micromolar range. Moreover, these new PDE10A inhibitors were able to decrease the nitrite production in LPS-stimulated cells, thus demonstrating their potential as anti-inflammatory agents.

  3. Cauchy problem of semi-linear parabolic equations with weak data in homogeneous space and application to the Navier-Stokes equations

    Institute of Scientific and Technical Information of China (English)

    苗长兴

    2003-01-01

    In this paper we study the Cauchy problem for a class of semi-linear parabolic type equations withweak data in the homogeneous spaces. We give a method which can be used to construct local mild solutionsof the abstract Cauchy problem in Cσ,s,p and Lq([O, T);Hs,p) by introducing the concept of both admissiblequintuplet and compatible space and establishing time-space estimates for solutions to the linear parabolic typeequations. For the small data, we prove that these results can be extended globally in time. We also study theregularity of the solution to the abstract Cauchy problem for nonlinear parabolic type equations in Cσ,s,p. Asan application, we obtain the same result for Navier-Stokes equations with weak initial data in homogeneousSobolev spaces.

  4. Two new designs of parabolic solar collectors

    Directory of Open Access Journals (Sweden)

    Karimi Sadaghiyani Omid

    2014-01-01

    Full Text Available In this work, two new compound parabolic trough and dish solar collectors are presented with their working principles. First, the curves of mirrors are defined and the mathematical formulation as one analytical method is used to trace the sun rays and recognize the focus point. As a result of the ray tracing, the distribution of heat flux around the inner wall can be reached. Next, the heat fluxes are calculated versus several absorption coefficients. These heat flux distributions around absorber tube are functions of angle in polar coordinate system. Considering, the achieved heat flux distribution are used as a thermal boundary condition. After that, Finite Volume Methods (FVM are applied for simulation of absorber tube. The validation of solving method is done by comparing with Dudley's results at Sandia National Research Laboratory. Also, in order to have a good comparison between LS-2 and two new designed collectors, some of their parameters are considered equal with together. These parameters are consist of: the aperture area, the measures of tube geometry, the thermal properties of absorber tube, the working fluid, the solar radiation intensity and the mass flow rate of LS-2 collector are applied for simulation of the new presented collectors. After the validation of the used numerical models, this method is applied to simulation of the new designed models. Finally, the outlet results of new designed collector are compared with LS-2 classic collector. Obviously, the obtained results from the comparison show the improving of the new designed parabolic collectors efficiency. In the best case-study, the improving of efficiency are about 10% and 20% for linear and convoluted models respectively.

  5. Sener Parabolic trough Collector Design and Testing

    Energy Technology Data Exchange (ETDEWEB)

    Castaneda, N.; Vazquez, J.; Domingo, M.

    2006-07-01

    Parabolic trough technology is nowadays the most extended solar system for electricity production or steam generation for industrial processes. It is basically composed of a collector field which converts solar irradiation into thermal energy- and a conventional thermal-toelectric conversion Rankine cycle. In these plants, a storage system can be implemented in order to increase plant production. Collector field represents more than half the total plant cost. Therefore, SENER has made an effort to improve current state of the art of parabolic trough collector (PTC from now on) design in order to reduce plant costs. Main characteristic of SENER design lies on the use of a torque tube as the central body of the collector. This tube is made of steel sheet, with a thickness depending on wind load requirements on the collector. This concept is very cost-effective, since the man-power needed to manufacture the tube has been minimized. Continuous cylindrical shape of the torque tube provides a high torsional stiffness, which is one of the main parameters affecting collector optical efficiency. Cantilever arms connect the mirrors to the central torque tube. These components are usually made of welded tube profiles. In SENER's new design, these cantilever arms are made using metal sheet stamping techniques (SENER patent), thus reducing manufacturing and mounting costs. SENER PTC module (called SENERTROUGH) is 12 meters long and has an aperture width of 5,76 m. HCE and curved mirrors existing in the market - as well as new products from different manufacturers - can be easily attached to collector structure. Two prototype modules of SENERTROUGH have been mounted and tested at the CIEMAT-PSA facilities. Several performance tests were performed in order to assure the validity of the concept. (Author)

  6. PDEs1-5 activity and expression in tissues of cirrhotic rats reveal a role for aortic PDE3 in NO desensitization.

    Science.gov (United States)

    Tahseldar-Roumieh, Rima; Keravis, Thérèse; Maarouf, Suha; Justiniano, Hélène; Sabra, Ramzi; Lugnier, Claire

    2009-12-01

    Liver cirrhosis is associated with increased nitric oxide (NO) production in the vasculature. We have previously demonstrated that aorta from rats with liver cirrhosis have a reduced relaxant response to NO donors that is corrected by DMPPO, a PDE5-specific inhibitor. Vasodilator responses to DMPPO itself were also reduced in rings from cirrhotic rats. These results supported previous suggestions that upregulation of PDE5 in liver cirrhosis might contribute to renal sodium retention, and consequently modulate vascular reactivity in the context of increased NO production (Tahseldar-Roumieh et al. in Am. J. Physiol. Heart Circ. Physiol. 290, H481-H488, 2006). Here, we investigated the possible alteration in activity and expression of cyclic nucleotide phosphodiesterase PDE1-PDE5 in kidney and vascular tissues in rats 4 weeks after bile duct ligation. The kidney of rats with cirrhosis had increased activity of PDE1 and PDE4 but not PDE5, and increased expression of PDE1A. Unexpectedly and interestingly, there was no change in cirrhotic aorta PDE5, but an increase in PDE3 and PDE4 activity associated with increased expression of PDE3A and PDE3B. Cilostamide, a specific PDE3 inhibitor, corrected the decreased response to an NO donor in isolated aorta from cirrhotic rats, suggesting that the difference in response to NO donors was due to differences in PDE3-induced hydrolysis of cGMP or to cGMP-induced inhibition of PDE3, rather than to differences in PDE5 contribution. In conclusion, these changes in PDE isozymes could greatly contribute to NO desensitization and to the regulation of vascular and renal function in liver cirrhosis.

  7. Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.

    Science.gov (United States)

    Havekes, Robbert; Park, Alan J; Tolentino, Rosa E; Bruinenberg, Vibeke M; Tudor, Jennifer C; Lee, Yool; Hansen, Rolf T; Guercio, Leonardo A; Linton, Edward; Neves-Zaph, Susana R; Meerlo, Peter; Baillie, George S; Houslay, Miles D; Abel, Ted

    2016-08-24

    Alterations in cAMP signaling are thought to contribute to neurocognitive and neuropsychiatric disorders. Members of the cAMP-specific phosphodiesterase 4 (PDE4) family, which contains >25 different isoforms, play a key role in determining spatial cAMP degradation so as to orchestrate compartmentalized cAMP signaling in cells. Each isoform binds to a different set of protein complexes through its unique N-terminal domain, thereby leading to targeted degradation of cAMP in specific intracellular compartments. However, the functional role of specific compartmentalized PDE4 isoforms has not been examined in vivo Here, we show that increasing protein levels of the PDE4A5 isoform in mouse hippocampal excitatory neurons impairs a long-lasting form of hippocampal synaptic plasticity and attenuates hippocampus-dependent long-term memories without affecting anxiety. In contrast, viral expression of a truncated version of PDE4A5, which lacks the unique N-terminal targeting domain, does not affect long-term memory. Further, overexpression of the PDE4A1 isoform, which targets a different subset of signalosomes, leaves memory undisturbed. Fluorescence resonance energy transfer sensor-based cAMP measurements reveal that the full-length PDE4A5, in contrast to the truncated form, hampers forskolin-mediated increases in neuronal cAMP levels. Our study indicates that the unique N-terminal localization domain of PDE4A5 is essential for the targeting of specific cAMP-dependent signaling underlying synaptic plasticity and memory. The development of compounds to disrupt the compartmentalization of individual PDE4 isoforms by targeting their unique N-terminal domains may provide a fruitful approach to prevent cognitive deficits in neuropsychiatric and neurocognitive disorders that are associated with alterations in cAMP signaling. Neurons exhibit localized signaling processes that enable biochemical cascades to be activated selectively in specific subcellular compartments. The

  8. Parabolic features and the erosion rate on Venus

    Science.gov (United States)

    Strom, Robert G.

    1993-01-01

    The impact cratering record on Venus consists of 919 craters covering 98 percent of the surface. These craters are remarkably well preserved, and most show pristine structures including fresh ejecta blankets. Only 35 craters (3.8 percent) have had their ejecta blankets embayed by lava and most of these occur in the Atla-Beta Regio region; an area thought to be recently active. parabolic features are associated with 66 of the 919 craters. These craters range in size from 6 to 105 km diameter. The parabolic features are thought to be the result of the deposition of fine-grained ejecta by winds in the dense venusian atmosphere. The deposits cover about 9 percent of the surface and none appear to be embayed by younger volcanic materials. However, there appears to be a paucity of these deposits in the Atla-Beta Regio region, and this may be due to the more recent volcanism in this area of Venus. Since parabolic features are probably fine-grain, wind-deposited ejecta, then all impact craters on Venus probably had these deposits at some time in the past. The older deposits have probably been either eroded or buried by eolian processes. Therefore, the present population of these features is probably associated with the most recent impact craters on the planet. Furthermore, the size/frequency distribution of craters with parabolic features is virtually identical to that of the total crater population. This suggests that there has been little loss of small parabolic features compared to large ones, otherwise there should be a significant and systematic paucity of craters with parabolic features with decreasing size compared to the total crater population. Whatever is erasing the parabolic features apparently does so uniformly regardless of the areal extent of the deposit. The lifetime of parabolic features and the eolian erosion rate on Venus can be estimated from the average age of the surface and the present population of parabolic features.

  9. Parabolic features and the erosion rate on Venus

    Science.gov (United States)

    Strom, Robert G.

    1993-01-01

    The impact cratering record on Venus consists of 919 craters covering 98 percent of the surface. These craters are remarkably well preserved, and most show pristine structures including fresh ejecta blankets. Only 35 craters (3.8 percent) have had their ejecta blankets embayed by lava and most of these occur in the Atla-Beta Regio region; an area thought to be recently active. parabolic features are associated with 66 of the 919 craters. These craters range in size from 6 to 105 km diameter. The parabolic features are thought to be the result of the deposition of fine-grained ejecta by winds in the dense venusian atmosphere. The deposits cover about 9 percent of the surface and none appear to be embayed by younger volcanic materials. However, there appears to be a paucity of these deposits in the Atla-Beta Regio region, and this may be due to the more recent volcanism in this area of Venus. Since parabolic features are probably fine-grain, wind-deposited ejecta, then all impact craters on Venus probably had these deposits at some time in the past. The older deposits have probably been either eroded or buried by eolian processes. Therefore, the present population of these features is probably associated with the most recent impact craters on the planet. Furthermore, the size/frequency distribution of craters with parabolic features is virtually identical to that of the total crater population. This suggests that there has been little loss of small parabolic features compared to large ones, otherwise there should be a significant and systematic paucity of craters with parabolic features with decreasing size compared to the total crater population. Whatever is erasing the parabolic features apparently does so uniformly regardless of the areal extent of the deposit. The lifetime of parabolic features and the eolian erosion rate on Venus can be estimated from the average age of the surface and the present population of parabolic features.

  10. Integration based profile likelihood calculation for PDE constrained parameter estimation problems

    Science.gov (United States)

    Boiger, R.; Hasenauer, J.; Hroß, S.; Kaltenbacher, B.

    2016-12-01

    Partial differential equation (PDE) models are widely used in engineering and natural sciences to describe spatio-temporal processes. The parameters of the considered processes are often unknown and have to be estimated from experimental data. Due to partial observations and measurement noise, these parameter estimates are subject to uncertainty. This uncertainty can be assessed using profile likelihoods, a reliable but computationally intensive approach. In this paper, we present the integration based approach for the profile likelihood calculation developed by (Chen and Jennrich 2002 J. Comput. Graph. Stat. 11 714-32) and adapt it to inverse problems with PDE constraints. While existing methods for profile likelihood calculation in parameter estimation problems with PDE constraints rely on repeated optimization, the proposed approach exploits a dynamical system evolving along the likelihood profile. We derive the dynamical system for the unreduced estimation problem, prove convergence and study the properties of the integration based approach for the PDE case. To evaluate the proposed method, we compare it with state-of-the-art algorithms for a simple reaction-diffusion model for a cellular patterning process. We observe a good accuracy of the method as well as a significant speed up as compared to established methods. Integration based profile calculation facilitates rigorous uncertainty analysis for computationally demanding parameter estimation problems with PDE constraints.

  11. Gene Therapy in a Large Animal Model of PDE6A-Retinitis Pigmentosa

    Directory of Open Access Journals (Sweden)

    Freya M. Mowat

    2017-06-01

    Full Text Available Despite mutations in the rod phosphodiesterase 6-alpha (PDE6A gene being well-recognized as a cause of human retinitis pigmentosa, no definitive treatments have been developed to treat this blinding disease. We performed a trial of retinal gene augmentation in the Pde6a mutant dog using Pde6a delivery by capsid-mutant adeno-associated virus serotype 8, previously shown to have a rapid onset of transgene expression in the canine retina. Subretinal injections were performed in 10 dogs at 29–44 days of age, and electroretinography and vision testing were performed to assess functional outcome. Retinal structure was assessed using color fundus photography, spectral domain optical coherence tomography, and histology. Immunohistochemistry was performed to examine transgene expression and expression of other retinal genes. Treatment resulted in improvement in dim light vision and evidence of rod function on electroretinographic examination. Photoreceptor layer thickness in the treated area was preserved compared with the contralateral control vector treated or uninjected eye. Improved rod and cone photoreceptor survival, rhodopsin localization, cyclic GMP levels and bipolar cell dendrite distribution was observed in treated areas. Some adverse effects including foci of retinal separation, foci of retinal degeneration and rosette formation were identified in both AAV-Pde6a and control vector injected regions. This is the first description of successful gene augmentation for Pde6a retinitis pigmentosa in a large animal model. Further studies will be necessary to optimize visual outcomes and minimize complications before translation to human studies.

  12. Identification of novel mutations confirms PDE4D as a major gene causing acrodysostosis.

    Science.gov (United States)

    Lynch, Danielle C; Dyment, David A; Huang, Lijia; Nikkel, Sarah M; Lacombe, Didier; Campeau, Philippe M; Lee, Brendan; Bacino, Carlos A; Michaud, Jacques L; Bernier, Francois P; Parboosingh, Jillian S; Innes, A Micheil

    2013-01-01

    Acrodysostosis is characterized by nasal hypoplasia, peripheral dysostosis, variable short stature, and intellectual impairment. Recently, mutations in PRKAR1A were reported in patients with acrodysostosis and hormone resistance. Subsequently, mutations in a phosphodiesterase gene (PDE4D) were identified in seven sporadic cases. We sequenced PDE4D in seven acrodysostosis patients from five families. Missense mutations were identified in all cases. Families showed de novo inheritance except one family with three affected children whose father was subsequently found to have subtle features of acrodysostosis. There were no recurrent mutations. Short stature and endocrine resistance are rare in this series; however, cognitive involvement and obesity were frequent. This last finding is relevant given PDE4D is insulin responsive and potentially involved in lipolysis. PDE4D encodes a cyclic AMP regulator and places PDE4D-related acrodysostosis within the same family of diseases as pseudohypoparathyroidism, pseudopseudohypoparathyroidism, PRKAR1A-related acrodysostosis and brachydactyly-mental retardation syndrome; all characterized by cognitive impairment and short distal extremities.

  13. PDE4在DISC1突变诱发的精神分裂症中的作用%The role of PDE4 in DISC1 mutation-induced schizophrenia

    Institute of Scientific and Technical Information of China (English)

    张舒; 王允山

    2012-01-01

    精神分裂症断裂基因1 (disrupted in schizophrenia 1,DISC1)是多种精神疾病中的一个关键的遗传学危险因素.DISC1能够与磷酸二酯酶4 (phosphodiesterase 4,PDE4)相互作用形成复合物,这可能是一些精神疾病的关键分子机制.PDE4能够水解cAMP,DISC1可通过调节PDE4的活性进而发挥调节cAMP在细胞内的信号转导功能.已有研究证实,在一些精神疾病患者中,DISC1和PDE4基因表达均发生了变化.DISC1突变导致其表达产物与PDE4的相互作用减弱,结果之一是降低脑PDE4的活性.DISC1与PDE4之间的相互作用的改变可能是精神分裂症及抑郁症等疾病症状产生的基础.%Disrupted in schizophrenia 1 (DISC1) is an important genetic risk factor for many mental diseases. DISC1 interacts directly with phosphodiesterase 4 (PDE4), and DISC1-PDE4 complexes are therefore likely to be involved in molecular mechanisms underlying psychiatric illnesses. PDE4 hydrolyses cAMP, and DISCI may regulate cAMP signalling through modulating PDE4 activity. There is evidence that the expression of both genes (DISCI and PDE4) is altered in some psychiatric patients. The mutation in DISCI reduces the interaction between DISCI and PDE4, and results in reduction of the activity of brain PDE4. Altered DISC1-PDE4 interaction may underlie the symptoms of schizophrenia and depression.

  14. Proceedings of the Fifth Parabolic Dish Solar Thermal Power Program

    Science.gov (United States)

    Lucas, J. W. (Editor)

    1984-01-01

    The proceedings of the Fifth Parabolic Dish Solar Thermal Power Program Annual Review are presented. The results of activities within the Parabolic Dish Technology and Module/Systems Development element of the Department of Energy's Solar Thermal Energy Systems Program were emphasized. Among the topics discussed were: overall Project and Program aspects, Stirling and Brayton module development, concentrator and engine/receiver development along with associated hardware and test results; distributed systems operating experience; international parabolic dish development activities; and non-DOE-sponsored domestic dish activities. Solar electric generation was also addressed.

  15. Parabolic Bundles on Algebraic Surfaces I -- The Donaldson-Uhlenbeck Compactification

    Indian Academy of Sciences (India)

    V Balaji; A Dey; R Parthasarathi

    2008-02-01

    The aim of this paper is to construct the parabolic version of the Donaldson-Uhlenbeck compactification for the moduli space of parabolic stable bundles on an algebraic surface with parabolic structures along a divisor with normal crossing singularities. We prove the non-emptiness of the moduli space of parabolic stable bundles of rank 2.

  16. Formation and stability analysis of parabolic pulses through specialty microstructured optical fibers at 2.1 μm

    Science.gov (United States)

    Biswas, P.; Adhikary, P.; Biswas, A.; Ghosh, S. N.

    2016-10-01

    We report a numerical study on formation and stability of parabolic pulses during their propagation through highly nonlinear specialty optical fibers. Here, we have formed a parabolic pulse at wavelength of 2.1 μm from a Gaussian input pulse with 1.9 ps FWHM and 75 W peak power after traveling through only 20 cm length from the input end of a 1 m long chalcogenide glass based microstructured optical fiber (MOF). Dependence on input pulse shapes towards most efficient conversion into self-similar states is reported. The stability in terms of any deviation from dissipative self-similar nature of such pulses has been analyzed by introducing a variable longitudinal loss profile within the spectral loss window of the MOF, and detailed pulse shapes are captured. Moreover, three different dispersion regimes of propagation have been considered to study the suitability to support most stable propagation of the pulse.

  17. Generation of parabolic similaritons in tapered silicon photonic wires: comparison of pulse dynamics at telecom and mid-infrared wavelengths.

    Science.gov (United States)

    Lavdas, Spyros; Driscoll, Jeffrey B; Jiang, Hongyi; Grote, Richard R; Osgood, Richard M; Panoiu, Nicolae C

    2013-10-01

    We study the generation of parabolic self-similar optical pulses in tapered Si photonic nanowires (Si-PhNWs) at both telecom (λ=1.55 μm) and mid-infrared (λ=2.2 μm) wavelengths. Our computational study is based on a rigorous theoretical model, which fully describes the influence of linear and nonlinear optical effects on pulse propagation in Si-PhNWs with arbitrarily varying width. Numerical simulations demonstrate that, in the normal dispersion regime, optical pulses evolve naturally into parabolic pulses upon propagation in millimeter-long tapered Si-PhNWs, with the efficiency of this pulse-reshaping process being strongly dependent on the spectral and pulse parameter regime in which the device operates, as well as the particular shape of the Si-PhNWs.

  18. Advantages of multigrid methods for certifying the accuracy of PDE modeling

    Science.gov (United States)

    Forester, C. K.

    1981-01-01

    Numerical techniques for assessing and certifying the accuracy of the modeling of partial differential equations (PDE) to the user's specifications are analyzed. Examples of the certification process with conventional techniques are summarized for the three dimensional steady state full potential and the two dimensional steady Navier-Stokes equations using fixed grid methods (FG). The advantages of the Full Approximation Storage (FAS) scheme of the multigrid technique of A. Brandt compared with the conventional certification process of modeling PDE are illustrated in one dimension with the transformed potential equation. Inferences are drawn for how MG will improve the certification process of the numerical modeling of two and three dimensional PDE systems. Elements of the error assessment process that are common to FG and MG are analyzed.

  19. A PDE Pricing Framework for Cross-Currency Interest Rate Derivatives with Target Redemption Features

    Science.gov (United States)

    Christara, Christina C.; Minh Dang, Duy; Jackson, Kenneth R.; Lakhany, Asif

    2010-09-01

    We propose a general framework for efficient pricing via a partial differential equation (PDE) approach for exotic cross-currency interest rate (IR) derivatives, with strong emphasis on long-dated foreign exchange (FX) IR hybrids, namely Power Reverse Dual Currency (PRDC) swaps with a FX Target Redemption (FX-TARN) provision. The FX-TARN provision provides a cap on the FX-linked PRDC coupon amounts, and once the accumulated coupon amount reaches this cap, the underlying PRDC swap terminates. Our PDE pricing framework is based on an auxiliary state variable to keep track of the total accumulated PRDC coupon amount. Finite differences on uniform grids and the Alternating Direction Implicit (ADI) method are used for the spatial and time discretizations, respectively, of the model-dependent PDE corresponding to each discretized value of the auxiliary variable. Numerical examples illustrating the convergence properties of the numerical methods are provided.

  20. Offset semi-parabolic nanoantenna made of a photonic crystal parabolic mirror and a plasmonic bow-tie antenna.

    Science.gov (United States)

    Hattori, Haroldo T

    2014-10-10

    In a parabolic mirror, light coming parallel to the antenna passes through its focal point. In this work, a waveguide feeds a semi-parabolic photonic crystal mirror and the emerging beam feeds a bow-tie antenna placed at the mirror's focal point-it is shown that the antenna system can not only feed a bow-tie antenna (producing a localized moderately high electric field) but also produces a directional radiation beam. The semi-parabolic mirror is also modified to reduce reflection back to the feeding waveguide.

  1. Pulmonary Hypertension Therapy and a Systematic Review of Efficacy and Safety of PDE-5 Inhibitors.

    Science.gov (United States)

    Unegbu, Chinwe; Noje, Corina; Coulson, John D; Segal, Jodi B; Romer, Lewis

    2017-03-01

    Pulmonary hypertension (PH) is a syndrome that is of growing concern to pediatricians worldwide. Recent data led to concerns about the safety of phosphodiesterase type 5 (PDE5) inhibitors in children and a US Food and Drug Administration safety advisory. Our objective is to provide insight into therapies for PH in children and to systematically review the comparative effectiveness and safety of PDE5 inhibitors in the management of pediatric patients with PH. We searched the following databases through February 2015: Medline, Embase, SCOPUS, and the Cochrane Central Register of Controlled Trials. We included studies that examined PDE5 inhibitor use in children with PH. Allowed comparators were either no medication or other classes of medication for management of PH. Study inclusion was via a 2-stage process with 2 reviewers and a predesigned form. Of 1270 papers identified by the literature search, 21 were included: 8 randomized controlled trials and 13 observational studies (9 retrospective, 4 prospective). There is strong evidence that PDE5 inhibitor use improves echocardiography measurements, cardiac catheterization parameters, and oxygenation compared with baseline or placebo in pediatric patients with PH. Evidence suggests that low- and moderate-dose sildenafil are safe regimens for children. There are a relatively small number of randomized controlled trials that address use of PDE5 inhibitors in pediatric patients with PH. PDE5 inhibitors are effective agents for cardiovascular and oxygenation end points in pediatric PH and important components of a multimodal pharmacotherapeutic approach to this growing challenge. Additional studies are needed to define optimal PH therapy in childhood.

  2. PDE5 Inhibitors As Potential Tools In The Treatment Of Cystic Fibrosis

    Directory of Open Access Journals (Sweden)

    Sabrina eNoel

    2012-09-01

    Full Text Available Despite great advances in the understanding of the genetics and pathophysiology of cystic fibrosis (CF, there is still no cure for the disease. Using phosphodiesterase type 5 (PDE5 inhibitors, we and others have provided evidence of rescued F508del-CFTR trafficking and corrected deficient chloride transport activity. Studies using PDE5 inhibitors in mice homozygous for the clinically relevant F508del mutation have been conducted with the aim of restoring F508del-CFTR protein function. We demonstrated, by measuring transepithelial nasal potential difference in F508del mice following intraperitoneal injection of sildenafil, vardenafil or taladafil at clinical doses are able to restore the decreased CFTR-dependent chloride transport across the nasal mucosa. Moreover, vardenafil, but not sildenafil, stimulates chloride transport through the normal CFTR protein. We developed a specific nebulizer setup for mice, with which we demonstrated, through a single inhalation of PDE5 inhibitors, local activation of CFTR protein in CF. Significant potential advantages of inhalation drug therapy over oral or intravenous routes include rapid onset of pharmacological action, reduced systemic secondary effects and reduced effective drug doses compared to the drug delivered orally; this underlines the relevance and impact of our work for translational science. More recently, we analyzed the bronchoalveolar lavage of CF and wild-type mice for cell infiltrates and expression of pro-inflammatory cytokines and chemokines; we found that the CFTR activating effect of vardenafil, selected as a representative long-lasting PDE5 inhibitor, breaks the vicious circle of lung inflammation which plays a major role in morbi-mortality in CF. Our data highlight the potential use of PDE5 inhibitors in CF. Therapeutic approaches using clinically approved PDE5 inhibitors to address F508del-CFTR defects could speed up the development of new therapies for CF.

  3. Pseudo almost periodic solutions to parabolic boundary value inverse problems

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    We first define the pseudo almost periodic functions in a more general setting.Then we show the existence,uniqueness and stability of pseudo almost periodic solutions of parabolic inverse problems for a type of boundary value problems.

  4. A Note about Parabolic Systems and Analytic Semigroups

    Institute of Scientific and Technical Information of China (English)

    STR?HMER Gerhard

    2011-01-01

    We investigate the question whether certain parabolic systems in the sense of Petrovskii fulfill the resolvent estimate required for the generation of an analytic semigroup and apply the result to a problem concerning the diffusion of gases.

  5. A SINGLE STEP SCHEME WITH HIGH ACCURACY FOR PARABOLIC PROBLEM

    Institute of Scientific and Technical Information of China (English)

    陈传淼; 胡志刚

    2001-01-01

    A single step scheme with high accuracy for solving parabolic problem is proposed. It is shown that this scheme possesses good stability and fourth order accuracy with respect to both time and space variables, which are superconvergent.

  6. An X-band parabolic antenna based on gradient metasurface

    Energy Technology Data Exchange (ETDEWEB)

    Yao, Wang; Yang, Helin, E-mail: emyang@mail.ccnu.edu.cn; Tian, Ying; Guo, Linyan [College of Physical Science and Technology, Central China Normal University, Wuhan 430079 (China); Huang, Xiaojun [College of Physical Science and Technology, Central China Normal University, Wuhan 430079 (China); College of physics and electrical engineering, Kashgar University, Kashgar, 844000 (China)

    2016-07-15

    We present a novel parabolic antenna by employing reflection gradient metasurface which is composed of a series of circle patches on a grounded dielectric substrate. Similar to the traditional parabolic antenna, the proposed antenna take the metasurface as a “parabolic reflector” and a patch antenna was placed at the focal point of the metasurface as a feed source, then the quasi-spherical wave emitted by the source is reflected and transformed to plane wave with high efficiency. Due to the focus effect of reflection, the beam width of the antenna has been decreased from 85.9° to 13° and the gain has been increased from 6.5 dB to 20.8 dB. Simulation and measurement results of both near and far-field plots demonstrate good focusing properties of the proposed parabolic antenna.

  7. On Doubly Degenerate Quasilinear Parabolic Equations of Higher Order

    Institute of Scientific and Technical Information of China (English)

    Zhen Hai LIU

    2005-01-01

    We deal with the existence of periodic solutions for doubly degenerate quasilinear parabolic equations of higher order, which can degenerate, on a part of the boundary, on a segment in the interior of the domain and in time.

  8. The homogenization of a class of degenerate quasilinear parabolic equations

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xingyou; HUANG Yong

    2003-01-01

    The homogenization of a class of degenerate quasilinear parabolic equations is studied. The Ap weight theory and the classical compensated compactness method are incorporated to obtain the homogenized equation.

  9. Classification of conformal representations induced from the maximal cuspidal parabolic

    Energy Technology Data Exchange (ETDEWEB)

    Dobrev, V. K., E-mail: dobrev@inrne.bas.bg [Scuola Internazionale Superiore di Studi Avanzati (Italy)

    2017-03-15

    In the present paper we continue the project of systematic construction of invariant differential operators on the example of representations of the conformal algebra induced from the maximal cuspidal parabolic.

  10. FASTRACK (TM): Parabolic and Suborbital Experiment Support Facility

    Science.gov (United States)

    Richards, Stephanie E. (Compiler); Levine, Howard G.; Romero, V.

    2016-01-01

    FASTRACK was developed by NASA Kennedy Space Center and Space Florida to provide capabilities to conduct frequent, affordable, and responsive flight opportunities for reduced gravity experiments, technology development, and hardware testing on suborbital vehicles and parabolic flights.

  11. Quasiconformal mappings and degenerate elliptic and parabolic equations

    Directory of Open Access Journals (Sweden)

    Filippo Chiarenza

    1987-11-01

    Full Text Available In this paper two Harnak inequalities are proved concerning a degenerate elliptic and a degenerate parabolic equation. In both cases the weight giving the degeneracy is a power of the jacobian of a quasiconformal mapping.

  12. PROBABILISTIC NUMERICAL APPROACH FOR PDE AND ITS APPLICATION IN THE VALUATION OF EUROPEAN OPTIONS

    Institute of Scientific and Technical Information of China (English)

    Dong-sheng Wu

    2001-01-01

    This paper suggests a probabilistic numerical approach for a class of PDE. First of all,by simulating Brownian motion and using Monte-Carlo method, we obtain a probabilistic numerical solution for the PDE. Then, we prove that the probabilistic numerical solution converges in probability to its solution. At the end of this paper, as an application, we give a probabilistic numerical approach for the valuation of European Options, where we see volatility σ, interest rate r and divident rate Do as functions of stock S, respectively.

  13. MAXIMUM PRINCIPLES FOR SECOND-ORDER PARABOLIC EQUATIONS

    Institute of Scientific and Technical Information of China (English)

    Antonio Vitolo

    2004-01-01

    This paper is the parabolic counterpart of previous ones about elliptic operators in unbounded domains. Maximum principles for second-order linear parabolic equations are established showing a variant of the ABP-Krylov-Tso estimate, based lower bound for super-solutions due to Krylov and Safonov. The results imply the uniqueness for the Cauchy-Dirichlet problem in a large class of infinite cylindrical and non-cylindrical domains.

  14. The parabolic trigonometric functions and the Chebyshev radicals

    OpenAIRE

    Dattoli, G.; Migliorati, M.; Ricci, P. E.

    2011-01-01

    The parabolic trigonometric functions have recently been introduced as an intermediate step between circular and hyperbolic functions. They have been shown to be expressible in terms of irrational functions, linked to the solution of third degree algebraic equations. We show the link of the parabolic trigonometric functions with the Chebyshev radicals and also prove that further generalized forms of trigonometric functions, providing the natural solutions of the quintic algebraic equation, ca...

  15. Comparison principle for parabolic equations in the Heisenberg group

    Directory of Open Access Journals (Sweden)

    Thomas Bieske

    2005-09-01

    Full Text Available We define two notions of viscosity solutions to parabolic equations in the Heisenberg group, depending on whether the test functions concern only the past or both the past and the future. We then exploit the Heisenberg geometry to prove a comparison principle for a class of parabolic equations and show the sufficiency of considering the test functions that concern only the past.

  16. Three-dimensional nonparaxial beams in parabolic rotational coordinates.

    Science.gov (United States)

    Deng, Dongmei; Gao, Yuanmei; Zhao, Juanying; Zhang, Peng; Chen, Zhigang

    2013-10-01

    We introduce a class of three-dimensional nonparaxial optical beams found in a parabolic rotational coordinate system. These beams, representing exact solutions of the nonparaxial Helmholtz equation, have inherent parabolic symmetries. Assisted with a computer-generated holography, we experimentally demonstrate the generation of different modes of these beams. The observed transverse beam patterns along the propagation direction agree well with those from our theoretical predication.

  17. Role of Ser102 and Ser104 as Regulators of cGMP Hydrolysis by PDE5A

    DEFF Research Database (Denmark)

    Carøe Nordgaard, Julie; Kruse, Lars Schack; Gammeltoft, Steen;

    2014-01-01

    -N-AS neuroblastoma cells as C-terminal fusions with green fluorescent protein. Transfected cells were treated with sildenafil, cilostazol, glyceryl trinitrate, calcitonin gene-related peptide (CGRP) or sumatriptan. PDE5A-GFP fusion proteins were localized in fixed cells by immunofluorescence and PDE activity...

  18. Association study of PDE4B gene variants in Scandinavian schizophrenia and bipolar disorder multicenter case-control samples

    DEFF Research Database (Denmark)

    Kähler, Anna K; Otnaess, Mona K; Wirgenes, Katrine V;

    2010-01-01

    The phosphodiesterase 4B (PDE4B), which is involved in cognitive function in animal models, is a candidate susceptibility gene for schizophrenia (SZ) and bipolar disorder (BP). Variations in PDE4B have previously been associated with SZ, with a suggested gender-specific effect. We have genotyped...

  19. A Note on a Nonlocal Nonlinear Reaction-Diffusion Model

    OpenAIRE

    Walker, Christoph

    2011-01-01

    We give an application of the Crandall-Rabinowitz theorem on local bifurcation to a system of nonlinear parabolic equations with nonlocal reaction and cross-diffusion terms as well as nonlocal initial conditions. The system arises as steady-state equations of two interacting age-structured populations.

  20. Phosphodiesterase 10A (PDE10A) localization in the R6/2 mouse model of Huntington's disease.

    Science.gov (United States)

    Leuti, Alessandro; Laurenti, Daunia; Giampà, Carmela; Montagna, Elena; Dato, Clemente; Anzilotti, Serenella; Melone, Mariarosa A B; Bernardi, Giorgio; Fusco, Francesca R

    2013-04-01

    In Huntington's disease (HD) mutant huntingtin protein impairs the function of several transcription factors, in particular the cAMP response element-binding protein (CREB). CREB activation can be increased by targeting phosphodiesterases such as phospohodiesterase 4 (PDE4) and phosphodiesterase 10A (PDE10A). Indeed, both PDE4 inhibition (DeMarch et al., 2008) and PDE10A inhibition (Giampà et al., 2010) proved beneficial in the R6/2 mouse model of HD. However, Hebb et al. (2004) reported PDE10A decline in R6/2 mice. These findings raise the issue of how PDE10A inhibition is beneficial in HD if such enzyme is lost. R6/2 mice and their wild type littermates were treated with the PDE10A inhibitor TP10 (a gift from Pfizer) or saline, sacrificed at 5, 9, and 13 weeks of age, and single and double label immunohistochemistry and western blotting were performed. PDE10A increased dramatically in the spiny neurons of R6/2 compared to the wild type mice. Conversely, in the striatal cholinergic interneurons, PDE10A was lower and it did not change significantly with disease progression. In the other subsets of striatal interneurons (namely, parvalbuminergic, somatostatinergic, and calretininergic interneurons) PDE10A immunoreactivity was higher in the R6/2 compared to the wild-type mice. In the TP10 treated R6/2, PDE10A levels were lower than in the saline treated mice in the medium spiny neurons, whereas they were higher in all subsets of striatal interneurons except for the cholinergic ones. However, in the whole striatum densitometry studies, PDE10A immunoreactivity was lower in the R6/2 compared to the wild-type mice. Our study demonstrates that PDE10A is increased in the spiny neurons of R6/2 mice striatum. Thus, the accumulation of PDE10A in the striatal projection neurons, by hydrolyzing greater amounts of cyclic nucleotides, is likely to contribute to cell damage in HD. Consequently, the beneficial effect of TP10 in HD models (Giampà et al., 2009, 2010) is explained

  1. Thermodynamics and the segmented compound parabolic concentrator

    Science.gov (United States)

    Widyolar, Bennett; Jiang, Lun; Winston, Roland

    2017-04-01

    Compound parabolic concentrator (CPC) reflector profiles are complex and can be difficult to manufacture using traditional methods. Computer numeric control machines, however, can approximate complex profiles by bending a series of small flat segments. We investigate the relationship between the number of segments and the optical transmission of a CPC approximated by equal length segments whose start and end points lie along the CPC profile. We also investigate a separate method for generating CPC-like profiles by adjusting the angle of each segment to satisfy the edge-ray principle. Three variations of this method are examined where the edge-ray condition is taken from the start, mid, and end points of each segment. A flux efficiency (FE) to compare concentrators, which combines the concentration ratio and optical efficiency, is introduced and directly relates to the maximum achievable flux on the absorber. We demonstrate that the FE defined is another way to look at the compromises one makes for a geometric concentrator designed under real-world constraints.

  2. Parabolic Trough Receiver Heat Loss Testing (Poster)

    Energy Technology Data Exchange (ETDEWEB)

    Price, H.; Netter, J.; Bingham, C.; Kutscher, C.; Burkholder, F.; Brandemuehl, M.

    2007-03-01

    Parabolic trough receivers, or heat collection elements (HCEs), absorb sunlight focused by the mirrors and transfer that thermal energy to a fluid flowing within them. Thje absorbing tube of these receivers typically operates around 400 C (752 F). HCE manufacturers prevent thermal loss from the absorbing tube to the environment by using sputtered selective Cermet coatings on the absorber and by surrounding the absorber with a glass-enclosed evacuated annulus. This work quantifies the heat loss of the Solel UVAC2 and Schott PTR70 HCEs. At 400 C, the HCEs perform similarly, losing about 400 W/m of HCE length. To put this in perspective, the incident beam radiation on a 5 m mirror aperture is about 4500 W/m, with about 75% of that energy ({approx} 3400 W/m) reaching the absorber surface. Of the 3400 W/m on the absorber, about 3000 W/m is absorbed into the working fluid while 400 W/m is lost to the environment.

  3. Parabolic Trough Solar Collector Initial Trials

    Directory of Open Access Journals (Sweden)

    Ghalya Pikra

    2012-03-01

    Full Text Available This paper discusses initial trials of parabolic trough solar collector (PTSC in Bandung. PTSC model consists of concentrator, absorber and tracking system. Concentrator designs are made with 2m aperture width, 6m length and 0.75m focal distance. The design is equipped with an automatic tracking system which is driven using 12V and 24Watt DC motor with 0.0125rpm rotational speed. Absorber/receiver is designed with evacuated tube type, with 1 inch core diameter and tube made of AISI304 and coated with black oxide, the outer tube is borosilicate glass with a 70 mm diameter and 1.5 m length. Working fluid stored in single type of thermal storage tank, a single phase with 37.7 liter volume. PTSC model testing carried out for 2 hours and 10 minutes produces heat output and input of 11.5 kW and 0.64 kW respectively. 

  4. Affective states and adaptation to parabolic flights

    Science.gov (United States)

    Collado, Aurélie; Langlet, Cécile; Tzanova, Tzvetomira; Hainaut, Jean-Philippe; Monfort, Vincent; Bolmont, Benoît

    2017-05-01

    This exploratory study investigates (i) inter-individual variations of affective states before a parabolic flight (i.e., PF) on the basis of quality of adaptation to physical demands, and (ii) intra-individual variations of affective states during a PF. Mood-states, state-anxiety and salivary cortisol were assessed in two groups with a different quality of adaptation (an Adaptive Group, i.e., AG, and a Maladaptive Group, i.e., MG) before and during a PF. Before PF, MG scored higher on mood states (Anger-Hostility, Fatigue-Inertia) than AG. During the flight, while AG seemed to present ;normal; affective responses to the demanding environment (e.g., increase in salivary cortisol), MG presented increases in mood states such as Confusion-Bewilderment or Tension-Anxiety. The findings suggest that the psychological states of MG could have disturbed their ability to integrate sensory information from an unusual environment, which led to difficulties in coping with the physical demands of PF.

  5. The 1D parabolic-parabolic Patlak-Keller-Segel model of chemotaxis: The particular integrable case and soliton solution

    Science.gov (United States)

    Shubina, Maria

    2016-09-01

    In this paper, we investigate the one-dimensional parabolic-parabolic Patlak-Keller-Segel model of chemotaxis. For the case when the diffusion coefficient of chemical substance is equal to two, in terms of travelling wave variables the reduced system appears integrable and allows the analytical solution. We obtain the exact soliton solutions, one of which is exactly the one-soliton solution of the Korteweg-de Vries equation.

  6. PDE-based geophysical modelling using finite elements: examples from 3D resistivity and 2D magnetotellurics

    Science.gov (United States)

    Schaa, R.; Gross, L.; du Plessis, J.

    2016-04-01

    We present a general finite-element solver, escript, tailored to solve geophysical forward and inverse modeling problems in terms of partial differential equations (PDEs) with suitable boundary conditions. Escript’s abstract interface allows geoscientists to focus on solving the actual problem without being experts in numerical modeling. General-purpose finite element solvers have found wide use especially in engineering fields and find increasing application in the geophysical disciplines as these offer a single interface to tackle different geophysical problems. These solvers are useful for data interpretation and for research, but can also be a useful tool in educational settings. This paper serves as an introduction into PDE-based modeling with escript where we demonstrate in detail how escript is used to solve two different forward modeling problems from applied geophysics (3D DC resistivity and 2D magnetotellurics). Based on these two different cases, other geophysical modeling work can easily be realized. The escript package is implemented as a Python library and allows the solution of coupled, linear or non-linear, time-dependent PDEs. Parallel execution for both shared and distributed memory architectures is supported and can be used without modifications to the scripts.

  7. Techniques in Linear and Nonlinear Partial Differential Equations

    Science.gov (United States)

    1991-10-21

    nonlinear partial differential equations , elliptic 15. NUMBER OF PAGES hyperbolic and parabolic. Variational methods. Vibration problems. Ordinary Five...NONLINEAR PARTIAL DIFFERENTIAL EQUATIONS FINAL TECHNICAL REPORT PROFESSOR LOUIS NIRENBERG OCTOBER 21, 1991 NT)S CRA&I D FIC ,- U.S. ARMY RESEARCH OFFICE...Analysis and partial differential equations . ed. C. Sadowsky. Marcel Dekker (1990) 567-619. [7] Lin, Fanghua, Asymptotic behavior of area-minimizing

  8. Linear and nonlinear degenerate abstract differential equations with small parameter

    OpenAIRE

    Shakhmurov, Veli B.

    2016-01-01

    The boundary value problems for linear and nonlinear regular degenerate abstract differential equations are studied. The equations have the principal variable coefficients and a small parameter. The linear problem is considered on a parameter-dependent domain (i.e., on a moving domain). The maximal regularity properties of linear problems and the optimal regularity of the nonlinear problem are obtained. In application, the well-posedness of the Cauchy problem for degenerate parabolic equation...

  9. Parabolic Wave Equation for Surface Water Waves.

    Science.gov (United States)

    1986-11-01

    extended to wave propagation problems in other fields of physical sciences, such as nonlinear optics ( Svelto , 1974), plasma physics (Karpman, 1975...34 Journal of Fluid Mechanics, Vol. 72, pp. 373-384. Svelto , 0., 1974, Progress in Optics, North-Holland Pub., Chapter 1, pp. 1-51. Tappert, F.D., 1977, "The

  10. Local classification of stable geometric solutions of systems of quasilinear first-order PDE

    Institute of Scientific and Technical Information of China (English)

    LI; Bing(李兵); LI; Yangcheng(李养成)

    2002-01-01

    Systems of quasilinear first order PDE are studied in the framework of contact manifold. All of the local stable geometric solutions of such systems are classified by using versal deformation and the classification of stable map germs of type ∑1 in singularity theory.

  11. Research on Odor Interaction between Aldehyde Compounds via a Partial Differential Equation (PDE Model

    Directory of Open Access Journals (Sweden)

    LuchunYan

    2015-01-01

    Full Text Available In order to explore the odor interaction of binary odor mixtures, a series of odor intensity evaluation tests were performed using both individual components and binary mixtures of aldehydes. Based on the linear relation between the logarithm of odor activity value and odor intensity of individual substances, the relationship between concentrations of individual constituents and their joint odor intensity was investigated by employing a partial differential equation (PDE model. The obtained results showed that the binary odor interaction was mainly influenced by the mixing ratio of two constituents, but not the concentration level of an odor sample. Besides, an extended PDE model was also proposed on the basis of the above experiments. Through a series of odor intensity matching tests for several different binary odor mixtures, the extended PDE model was proved effective at odor intensity prediction. Furthermore, odorants of the same chemical group and similar odor type exhibited similar characteristics in the binary odor interaction. The overall results suggested that the PDE model is a more interpretable way of demonstrating the odor interactions of binary odor mixtures.

  12. A Nonsense Mutation in PDE6H Causes Autosomal-Recessive Incomplete Achromatopsia.

    NARCIS (Netherlands)

    Kohl, S.; Coppieters, F.; Meire, F.; Schaich, S.; Roosing, S.; Brennenstuhl, C.; Bolz, S.; Genderen, M.M. van; Riemslag, F.C.; Lukowski, R.; Hollander, A.I. den; Cremers, F.P.M.; Baere, E. de; Hoyng, C.B.; Wissinger, B.

    2012-01-01

    Achromatopsia (ACHM) is an autosomal-recessive retinal dystrophy characterized by color blindness, photophobia, nystagmus, and severely reduced visual acuity. Its prevalence has been estimated to about 1 in 30,000 individuals. Four genes, GNAT2, PDE6C, CNGA3, and CNGB3, have been implicated in ACHM,

  13. Riccati inequality and oscillation criteria for PDE with P-laplacian

    Directory of Open Access Journals (Sweden)

    2006-01-01

    Full Text Available Oscillation criteria for PDE with P-Laplacian div ( A( x ‖ Du ‖ p−2 Du +P( x | u | p−2 u=0 are obtained via Riccati inequality. Some of them are extensions of the results for the second-order linear ODE to this equation.

  14. PDE-based random-valued impulse noise removal based on new class of controlling functions.

    Science.gov (United States)

    Wu, Jian; Tang, Chen

    2011-09-01

    This paper is concerned with partial differential equation (PDE)-based image denoising for random-valued impulse noise. We introduce the notion of ENI (the abbreviation for "edge pixels, noisy pixels, and interior pixels") that denotes the number of homogeneous pixels in a local neighborhood and is significantly different for edge pixels, noisy pixels, and interior pixels. We redefine the controlling speed function and the controlling fidelity function to depend on ENI. According to our two controlling functions, the diffusion and fidelity process at edge pixels, noisy pixels, and interior pixels can be selectively carried out. Furthermore, a class of second-order improved and edge-preserving PDE denoising models is proposed based on the two new controlling functions in order to deal with random-valued impulse noise reliably. We demonstrate the performance of the proposed PDEs via application to five standard test images, corrupted by random-valued impulse noise with various noise levels and comparison with the related second-order PDE models and the other special filtering methods for random-valued impulse noise. Our two controlling functions are extended to automatically other PDE models.

  15. Identification and characterization of DdPDE3, a cGMP-selective phosphodiesterase from Dictyostelium

    NARCIS (Netherlands)

    Kuwayama, H; Snippe, H; Derks, M; Roelofs, J; van Haastert, PJM

    2001-01-01

    In Dictyostelium cAMP and cGMP have important functions as first and second messengers in chemotaxis and development. Two cyclic-nucleotide phosphodiesterases (DdPDE 1 and 2) have been identified previously, an extracellular dual-specificity enzyme and an intracellular cAMP-specific enzyme (encoded

  16. A Nonsense Mutation in PDE6H Causes Autosomal-Recessive Incomplete Achromatopsia.

    NARCIS (Netherlands)

    Kohl, S.; Coppieters, F.; Meire, F.; Schaich, S.; Roosing, S.; Brennenstuhl, C.; Bolz, S.; Genderen, M.M. van; Riemslag, F.C.; Lukowski, R.; Hollander, A.I. den; Cremers, F.P.M.; Baere, E. de; Hoyng, C.B.; Wissinger, B.

    2012-01-01

    Achromatopsia (ACHM) is an autosomal-recessive retinal dystrophy characterized by color blindness, photophobia, nystagmus, and severely reduced visual acuity. Its prevalence has been estimated to about 1 in 30,000 individuals. Four genes, GNAT2, PDE6C, CNGA3, and CNGB3, have been implicated in ACHM,

  17. #DDOD Use Case: Access to Medicare Part D Drug Event File (PDE) for cost transparency

    Data.gov (United States)

    U.S. Department of Health & Human Services — SUMMARY DDOD use case to request access to Medicare Part D Drug Event File (PDE) for cost transparency to pharmacies and patients. WHAT IS A USE CASE? A “Use Case”...

  18. Synthesis and bioactivity of pyrazole and triazole derivatives as potential PDE4 inhibitors.

    Science.gov (United States)

    Li, Ya-Sheng; Tian, Hao; Zhao, Dong-Sheng; Hu, De-Kun; Liu, Xing-Yu; Jin, Hong-Wei; Song, Gao-Peng; Cui, Zi-Ning

    2016-08-01

    A series of pyrazole and triazole derivatives containing 5-phenyl-2-furan functionality were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. The bioassay results showed that title compounds exhibited considerable inhibitory activity against PDE4B and blockade of LPS-induced TNFα release. Meanwhile, the activity of compounds containing 1,2,4-triazole (series II) was higher than that of pyrazole-attached derivatives (series I). The primary structure-activity relationship study and docking results showed that the 1,2,4-triazole moiety of compound IIk played a key role to form integral hydrogen bonds and π-π stacking interaction with PDE4B protein while the rest part of the molecule extended into the catalytic domain to block the access of cAMP and formed the foundation for inhibition of PDE4. Compound IIk would be great promise as a hit compound for further study based on the preliminary structure-activity relationship and molecular modeling studies.

  19. Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype.

    Science.gov (United States)

    Libé, Rossella; Horvath, Anelia; Vezzosi, Delphine; Fratticci, Amato; Coste, Joel; Perlemoine, Karine; Ragazzon, Bruno; Guillaud-Bataille, Marine; Groussin, Lionel; Clauser, Eric; Raffin-Sanson, Marie-Laure; Siegel, Jennifer; Moran, Jason; Drori-Herishanu, Limor; Faucz, Fabio Rueda; Lodish, Maya; Nesterova, Maria; Bertagna, Xavier; Bertherat, Jerome; Stratakis, Constantine A

    2011-01-01

    Carney complex (CNC) is an autosomal dominant multiple neoplasia, caused mostly by inactivating mutations of the regulatory subunit 1A of the protein kinase A (PRKAR1A). Primary pigmented nodular adrenocortical disease (PPNAD) is the most frequent endocrine manifestation of CNC with a great inter-individual variability. Germline, protein-truncating mutations of phosphodiesterase type 11A (PDE11A) have been described to predispose to a variety of endocrine tumors, including adrenal and testicular tumors. Our objective was to investigate the role of PDE11A as a possible gene modifier of the phenotype in a series of 150 patients with CNC. A higher frequency of PDE11A variants in patients with CNC compared with healthy controls was found (25.3 vs. 6.8%, P CNC patients, those with PPNAD were significantly more frequently carriers of PDE11A variants compared with patients without PPNAD (30.8 vs. 13%, P = 0.025). Furthermore, men with PPNAD were significantly more frequently carriers of PDE11A sequence variants (40.7%) than women with PPNAD (27.3%) (P CNC patients, a high frequency of PDE11A variants, suggesting that PDE11A is a genetic modifying factor for the development of testicular and adrenal tumors in patients with germline PRKAR1A mutation.

  20. Parabolic trough Project in Cerro Prieto, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Lentz, A.; Cadenas, R.; Almanza, R.; Martinez, I.; Ruiz, V.

    2006-07-01

    Federal Electricity Commission (CFE), the most important electricity Company in Mexico wants to install a parabolic trough row in the Cerro Prieto Geothermal field. Cerro Prieto (CP) is the most important geothermal field in Mexico; this area has the highest levels of irradiance in the country. The levels of irradiance make it feasible to set up a solar collector field in the geothermal field to build a hybrid system in order to increase the steam and electricity production. There are several alternative in the hybrid system, depending where the solar field place is located. Two new options are presented in this paper. The first one uses water from the condenser in DSG with the solar field and steam is separated in the first separator. The second option (DSG), the steam produced is separated in an expansion vessel; the water is reinjected in the solar field and the steam goes to the turbine. This project plans to install an experimental facility to research and learning about the technology, CFE main objective will be the electricity generation; using steam from solar collectors using the existing turbines in CPIV; the second objective is to instruct the workers in the operation of the real facility. The third objective is to study the geothermal flow in the absorbers in Direct Steam Generation (DSG), which has salt and silica dissolved, and look for a possible solution for steam generation. The geothermal facilities have considerable experience using the brine flow, so it is not considered an impediment in the solar-geothermal hybrid system. (Author)

  1. The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses.

    Science.gov (United States)

    Vanmierlo, Tim; Creemers, Pim; Akkerman, Sven; van Duinen, Marlies; Sambeth, Anke; De Vry, Jochen; Uz, Tolga; Blokland, Arjan; Prickaerts, Jos

    2016-04-15

    Enhancement of central availability of the second messenger cAMP is a promising approach to improve cognitive function. Pharmacological inhibition of phosphodiesterase type 4 (PDE4), a group of cAMP hydrolyzing enzymes in the brain, has been shown to improve cognitive performances in rodents and monkeys. However, inhibition of PDE4 is generally associated with severe emetic side-effects. Roflumilast, an FDA-approved PDE4 inhibitor for treatment of chronic obstructive pulmonary disease (COPD), is yielding only mild emetic side effects. In the present study we investigate the potential of roflumilast as a cognition enhancer and to determine the potential coinciding emetic response in comparison to rolipram, a classic PDE4 inhibitor with pronounced emetic effects. Cognition enhancement was evaluated in mice and it was found that both roflumilast and rolipram enhanced memory in an object location task (0.03mg/kg), whereas only roflumilast was effective in a spatial Y-maze (0.1mg/kg). Emetic potential was measured using competition of PDE4 inhibition for α2-adrenergic receptor antagonism in which recovery from xylazine/ketamine-mediated anesthesia is used as a surrogate marker. While rolipram displayed emetic properties at a dose 10 times the memory-enhancing dose, roflumilast only showed increased emetic-like properties at a dose 100 times the memory-enhancing dose. Moreover, combining sub-efficacious doses of the approved cognition-enhancer donepezil and roflumilast, which did not improve memory when given alone, fully restored object recognition memory deficit in rats induced by the muscarinic receptor antagonist scopolamine. These findings suggest that roflumilast offers a more favorable window for treatment of cognitive deficits compared to rolipram.

  2. Optical properties of parabolic quantum dots with dressed impurity: Combined effects of pressure, temperature and laser intensity

    Energy Technology Data Exchange (ETDEWEB)

    Vaseghi, B., E-mail: vaseghi@mail.yu.ac.ir; Rezaei, G.; Sajadi, T.

    2015-01-01

    In this paper simultaneous effects of pressure, temperature and laser radiation on the optical absorption coefficient and refractive index of a spherical quantum dot with parabolic confinement and dressed impurity are studied. By means of matrix diagonalization technique, energy eigenvalues and functions are evaluated and used to find the optical properties of the system via density operator method. It is shown that linear and nonlinear optical properties strongly depend on pressure, temperature and dressing laser intensity. The interesting point is that the influence of laser radiation depends on pressure and temperature.

  3. Space-Time Estimates of Mild Solutions of a Class of Higher-Order Semilinear Parabolic Equations in Lp

    Directory of Open Access Journals (Sweden)

    Sandjo Albert N.

    2014-01-01

    Full Text Available We establish the well-posedness of boundary value problems for a family of nonlinear higherorder parabolic equations which comprises some models of epitaxial growth and thin film theory. In order to achieve this result, we provide a unified framework for constructing local mild solutions in C0([0, T]; Lp(Ω by introducing appropriate time-weighted Lebesgue norms inspired by a priori estimates of solutions. This framework allows us to obtain global existence of solutions under the proviso that initial data are reasonably small

  4. EXISTENCE OF POSITIVE SOLUTIONS FOR A CLASS OF PARABOLIC EQUATIONS WITH NATURAL GROWTH TERMS AND L1 DATA

    Institute of Scientific and Technical Information of China (English)

    Kaouther AMMAR; Hicham REDWANE

    2014-01-01

    We study a class of nonlinear parabolic equations of the type:∂b(u)∂t -diva(x, t, u)∇u+g(u)|∇u|2=f, where the right hand side belongs to L1(Q), b is a strictly increasing C1-function and-div(a(x, t, u)∇u) is a Leray-Lions operator. The function g is just assumed to be con-tinuous on R and to satisfy a sign condition. Without any additional growth assumption on u, we prove the existence of a renormalized solution.

  5. Structural transitions and long-time self-diffusion of interacting colloids confined by a parabolic potential.

    Science.gov (United States)

    Euán-Díaz, Edith C; Herrera-Velarde, Salvador; Misko, Vyacheslav R; Peeters, François M; Castañeda-Priego, Ramón

    2015-01-14

    We report on the ordering and dynamics of interacting colloidal particles confined by a parabolic potential. By means of Brownian dynamics simulations, we find that by varying the magnitude of the trap stiffness, it is possible to control the dimension of the system and, thus, explore both the structural transitions and the long-time self-diffusion coefficient as a function of the degree of confinement. We particularly study the structural ordering in the directions perpendicular and parallel to the confinement. Further analysis of the local distribution of the first-neighbors layer allows us to identify the different structural phases induced by the parabolic potential. These results are summarized in a structural state diagram that describes the way in which the colloidal suspension undergoes a structural re-ordering while increasing the confinement. To fully understand the particle dynamics, we take into account hydrodynamic interactions between colloids; the parabolic potential constricts the available space for the colloids, but it does not act on the solvent. Our findings show a non-linear behavior of the long-time self-diffusion coefficient that is associated to the structural transitions induced by the external field.

  6. Preventing Blow up by Convective Terms in Dissipative PDE's

    Science.gov (United States)

    Bilgin, Bilgesu; Kalantarov, Varga; Zelik, Sergey

    2016-09-01

    We study the impact of the convective terms on the global solvability or finite time blow up of solutions of dissipative PDEs. We consider the model examples of 1D Burger's type equations, convective Cahn-Hilliard equation, generalized Kuramoto-Sivashinsky equation and KdV type equations. The following common scenario is established: adding sufficiently strong (in comparison with the destabilizing nonlinearity) convective terms to equation prevents the solutions from blowing up in a finite time and makes the considered system globally well-posed and dissipative and for weak enough convective terms the finite time blow up may occur similar to the case, when the equation does not involve convective term. This kind of result has been previously known for the case of Burger's type equations and has been strongly based on maximum principle. In contrast to this, our results are based on the weighted energy estimates which do not require the maximum principle for the considered problem.

  7. Influences of finite gain bandwidth on pulse propagation in parabolic fiber amplifiers with distributed gain profiles

    Institute of Scientific and Technical Information of China (English)

    Zhao Jia-Sheng; Li Pan; Chen Xiao-Dong; Feng Su-Juan; Mao Qing-He

    2012-01-01

    The evolutions of the pulses propagating in decreasing and increasing gain distributed fiber amplifiers with finite gain bandwidths are investigated by simulations with the nonlinear Schrodinger equation.The results show that the parabolic pulse propagations in both the decreasing and the increasing gain amplifiers are restricted by the finite gain bandwidth.For a given input pulse,by choosing a small initial gain coefficient and gain variation rate,the whole gain for the pulse amplification limited by the gain bandwidth may be higher,which is helpful for the enhancement of the output linearly chirped pulse energy.Compared to the decreasing gain distributed fiber amplifier,the increasing gain distributed amplifier may be more conducive to suppress the pulse spectral broadening and increase the critical amplifier length for achieving a larger output linearly chirped pulse energy.

  8. Study of degenerate parabolic system modeling the hydrogen displacement in a nuclear waste repository

    CERN Document Server

    Caro, Florian; Saad, Mazen

    2012-01-01

    Our goal is the mathematical analysis of a two phase (liquid and gas) two components (water and hydrogen) system modeling the hydrogen displacement in a storage site for radioactive waste. We suppose that the water is only in the liquid phase and is incompressible. The hydrogen in the gas phase is supposed compressible and could be dissolved into the water with the Henry's law. The flow is described by the conservation of the mass of each components. The model is treated without simplified assumptions on the gas density. This model is degenerated due to vanishing terms. We establish an existence result for the nonlinear degenerate parabolic system based on new energy estimate on pressures.

  9. Study of degenerate parabolic system modeling the hydrogen displacement in a nuclear waste repository

    KAUST Repository

    Caro, Florian

    2013-09-01

    Our goal is the mathematical analysis of a two phase (liquid and gas) two components (water and hydrogen) system modeling the hydrogen displacement in a storage site for radioactive waste. We suppose that the water is only in the liquid phase and is incompressible. The hydrogen in the gas phase is supposed compressible and could be dissolved into the water with the Henry law. The flow is described by the conservation of the mass of each components. The model is treated without simplified assumptions on the gas density. This model is degenerated due to vanishing terms. We establish an existence result for the nonlinear degenerate parabolic system based on new energy estimate on pressures.

  10. Sildenafil and analogous phosphodiesterase type 5 (PDE-5) inhibitors in herbal food supplements sampled on the Dutch market.

    Science.gov (United States)

    Reeuwijk, N M; Venhuis, B J; de Kaste, D; Hoogenboom, L A P; Rietjens, I M C M; Martena, M J

    2013-01-01

    Herbal food supplements, claiming to enhance sexual potency, may contain deliberately added active pharmacological ingredients (APIs) that can be used for the treatment of erectile dysfunction (ED). The aim of this study was to determine whether herbal food supplements on the Dutch market indeed contain APIs that inhibit phosphodiesterase type 5 (PDE-5) inhibitors, such as sildenafil and analogous PDE-5 inhibitors. Herbal food supplements intended to enhance sexual potency (n = 71), and two soft drinks, were sampled from 2003 up to and including 2012. In 23 herbal supplements, nine different PDE-5 inhibitors were identified; in a few cases (n = 3), more than one inhibitor was indentified. The presence of these APIs was however not stated on the label. The concentrations of PDE-5 inhibitors per dose unit were analysed. Furthermore, the potential pharmacologically active properties of the detected PDE-5 inhibitors were estimated by using data from the scientific and patent literature regarding (1) in vitro PDE-5 activity, (2) reported effective doses of registered drugs with PDE-5 inhibitor activity and (3) similarity to other structural analogues. It was concluded that 18 of the 23 herbal food supplements, when used as recommended, would have significant pharmacological effects due to added APIs. Adequate use of existing regulation and control measures seems necessary to protect consumers against the adverse effects of these products.

  11. Reasons and predictive factors for discontinuation of PDE-5 inhibitors despite successful intercourse in erectile dysfunction patients

    Science.gov (United States)

    Kim, S-C; Lee, Y-S; Seo, K-K; Jung, G-W; Kim, T-H

    2014-01-01

    This study was aimed to identify characteristics of ED patients who discontinued PDE5i despite successful intercourse. Data were collected using a questionnaire from 34 urologic clinics regardless of the effect (success or failure) of PDE5i treatment by visiting the clinics (717), e-mail (64) or post (101) for 882 ED patients who had previously taken any kind of PDE5i on demand four or more times. Discontinuation of PDE5i was defined if the patient had never taken PDE5i for the previous 1 year despite successful intercourse. Of the 882 patients, 485 were included in the final analysis. Difference in the socio-demographic, ED- and partner-related data between the continuation and discontinuation group and factors influencing discontinuation of the PDE5i were analyzed. Among 485 respondents (mean age, 53.6), 116 (23.9%) had discontinued PDE5i use despite successful intercourse. Most common reasons for the discontinuation were ‘reluctant medication-dependent intercourse' (31.0%), ‘spontaneous recovery of erectile function without further treatment' (30.2%), and ‘high cost' (26.7%). In multiple logistic regression analysis, independent factors influencing discontinuation of the drug were cause of ED (psychogenic), short duration of ED, low education (⩽ middle school), and religion (Catholic). In partner-related compliance, only partner's religion (Catholic) was a significant factor. PMID:24305610

  12. Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia.

    Science.gov (United States)

    Blanchard, Elise; Zlock, Lorna; Lao, Anna; Mika, Delphine; Namkung, Wan; Xie, Moses; Scheitrum, Colleen; Gruenert, Dieter C; Verkman, Alan S; Finkbeiner, Walter E; Conti, Marco; Richter, Wito

    2014-02-01

    Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) that impair its expression and/or chloride channel function. Here, we provide evidence that type 4 cyclic nucleotide phosphodiesterases (PDE4s) are critical regulators of the cAMP/PKA-dependent activation of CFTR in primary human bronchial epithelial cells. In non-CF cells, PDE4 inhibition increased CFTR activity under basal conditions (ΔISC 7.1 μA/cm(2)) and after isoproterenol stimulation (increased ΔISC from 13.9 to 21.0 μA/cm(2)) and slowed the return of stimulated CFTR activity to basal levels by >3-fold. In cells homozygous for ΔF508-CFTR, the most common mutation found in CF, PDE4 inhibition alone produced minimal channel activation. However, PDE4 inhibition strongly amplified the effects of CFTR correctors, drugs that increase expression and membrane localization of CFTR, and/or CFTR potentiators, drugs that increase channel gating, to reach ∼ 25% of the chloride conductance observed in non-CF cells. Biochemical studies indicate that PDE4s are anchored to CFTR and mediate a local regulation of channel function. Taken together, our results implicate PDE4 as an important determinant of CFTR activity in airway epithelia, and support the use of PDE4 inhibitors to potentiate the therapeutic benefits of CFTR correctors and potentiators.

  13. Performance Simulation Comparison for Parabolic Trough Solar Collectors in China

    Directory of Open Access Journals (Sweden)

    Jinping Wang

    2016-01-01

    Full Text Available Parabolic trough systems are the most used concentrated solar power technology. The operating performance and optical efficiency of the parabolic trough solar collectors (PTCs are different in different regions and different seasons. To determine the optimum design and operation of the parabolic trough solar collector throughout the year, an accurate estimation of the daily performance is needed. In this study, a mathematical model for the optical efficiency of the parabolic trough solar collector was established and three typical regions of solar thermal utilization in China were selected. The performance characteristics of cosine effect, shadowing effect, end loss effect, and optical efficiency were calculated and simulated during a whole year in these three areas by using the mathematical model. The simulation results show that the optical efficiency of PTCs changes from 0.4 to 0.8 in a whole year. The highest optical efficiency of PTCs is in June and the lowest is in December. The optical efficiency of PTCs is mainly influenced by the solar incidence angle. The model is validated by comparing the test results in parabolic trough power plant, with relative error range of 1% to about 5%.

  14. A Contribution for the Construction of Parabolic Mirrors

    CERN Document Server

    de Paula, L A N; Assis, A K T

    2008-01-01

    We present a new procedure for the construction of parabolic mirrors using low cost materials. We build a spinning system composed of nylon threads, fish hooks and a plastic bucket. We pour liquid plaster into the bucket and set it in constant rotational motion relative to the earth. A liquid substance assumes a parabolic profile when spinning at constant angular velocity relative to an inertial frame under the influence of an uniform vertical gravitational field. By keeping the bucket under rotation for a long time, the plaster solidifies into a parabolic format. We utilize this solidified plaster paraboloid as a model to construct a counter-mould of glass fibre and resin. Over this counter-mould it is placed stretched laminated foil and then it is poured thick plaster over it. In this way it is obtained a parabolic mirror made of laminated foil and plaster. Our only objective here is to present a new method for the construction of parabolic mirror using low cost materials. This allows further exploration of...

  15. Fabrication, Designing & Performance Analysis of Solar Parabolic Trough

    Directory of Open Access Journals (Sweden)

    Mayur G. Tayade,

    2014-07-01

    Full Text Available A parabolic trough solar collector uses a parabolic cylinder to reflect and concentrate sun radiations towards a receiver tube located at the focus line of the parabolic cylinder. The receiver absorbs the incoming radiations and transforms them into thermal energy, the latter being transported and collected by a fluid medium circulating within the receiver tube.This method of concentrated solar collection has the advantage of high efficiency and low cost, and can be used either for thermal energy collection, for generating electricity or for both, This paper focused on the fabrication and designing of solar parabolic trough, The designing of trough is depend upon the following parameters : Aperture of the concentrator , Inner diameter of absorber tube, Outer diameter of absorber tube, Inner diameter of glass tube, Outer diameter of glass tube, Length of parabolic trough, Concentration ratio, Collector aperture area, Specular reflectivity of concentrator, Glass cover transitivity for solar radiation, Absorber tube emissivity/emissivity, Intercept factor, Emissivity of absorber tube surface and Emissivity of glass. The performance analysis will be based on the Experimental data collection and calculations with reference to: Thermal performance calculations, Overall loss coefficient and heat correlations. Heat transfer coefficient on the inside surface of the absorber tube and Heat transfer coefficient between the absorber tube and the Cover.

  16. Rolipram Attenuates Bile Duct Ligation–Induced Liver Injury in Rats: A Potential Pathogenic Role of PDE4

    Science.gov (United States)

    Barve, Shirish; Breitkopf-Heinlein, Katja; Li, Yan; Zhang, JingWen; Avila, Diana V.; Dooley, Steven; McClain, Craig J.

    2013-01-01

    Anti-inflammatory and antifibrotic effects of the broad spectrum phosphodiesterase (PDE) inhibitor pentoxifylline have suggested an important role for cyclic nucleotides in the pathogenesis of hepatic fibrosis; however, studies examining the role of specific PDEs are lacking. Endotoxemia and Toll-like receptor 4 (TLR4)-mediated inflammatory and profibrotic signaling play a major role in the development of hepatic fibrosis. Because cAMP-specific PDE4 critically regulates lipopolysaccharide (LPS)-TLR4–induced inflammatory cytokine expression, its pathogenic role in bile duct ligation-induced hepatic injury and fibrogenesis in Sprague-Dawley rats was examined. Initiation of cholestatic liver injury and fibrosis was accompanied by a significant induction of PDE4A, B, and D expression and activity. Treatment with the PDE4-specific inhibitor rolipram significantly decreased liver PDE4 activity, hepatic inflammatory and profibrotic cytokine expression, injury, and fibrosis. At the cellular level, in relevance to endotoxemia and inflammatory cytokine production, PDE4B was observed to play a major regulatory role in the LPS-inducible tumor necrosis factor (TNF) production by isolated Kupffer cells. Moreover, PDE4 expression was also involved in the in vitro activation and transdifferentiation of isolated hepatic stellate cells (HSCs). Particularly, PDE4A, B, and D upregulation preceded induction of the HSC activation marker α-smooth muscle actin (α-SMA). In vitro treatment of HSCs with rolipram effectively attenuated α-SMA, collagen expression, and accompanying morphologic changes. Overall, these data strongly suggest that upregulation of PDE4 expression during cholestatic liver injury plays a potential pathogenic role in the development of inflammation, injury, and fibrosis. PMID:23887098

  17. Accelerated parabolic Radon domain 2D adaptive multiple subtraction with fast iterative shrinkage thresholding algorithm and its application in parabolic Radon domain hybrid demultiple method

    Science.gov (United States)

    Li, Zhong-xiao; Li, Zhen-chun

    2017-08-01

    Adaptive multiple subtraction is an important step for successfully conducting surface-related multiple elimination in marine seismic exploration. 2D adaptive multiple subtraction conducted in the parabolic Radon domain has been proposed to better separate primaries and multiples than 2D adaptive multiple subtraction conducted in the time-offset domain. Additionally, the parabolic Radon domain hybrid demultiple method combining parabolic Radon filtering and parabolic Radon domain 2D adaptive multiple subtraction can better remove multiples than the cascaded demultiple method using time-offset domain 2D adaptive multiple subtraction and the parabolic Radon transform method sequentially. To solve the matching filter in the optimization problem with L1 norm minimization constraint of primaries, traditional parabolic Radon domain 2D adaptive multiple subtraction uses the iterative reweighted least squares (IRLS) algorithm, which is computationally expensive for solving a weighted LS inversion in each iteration. In this paper we introduce the fast iterative shrinkage thresholding algorithm (FISTA) as a faster alternative to the IRLS algorithm for parabolic Radon domain 2D adaptive multiple subtraction. FISTA uses the shrinkage-thresholding operator to promote the sparsity of estimated primaries and solves the 2D matching filter with iterative steps. FISTA based parabolic Radon domain 2D adaptive multiple subtraction reduces the computation time effectively while achieving similar accuracy compared with IRLS based parabolic Radon domain 2D adaptive multiple subtraction. Additionally, the provided examples show that FISTA based parabolic Radon domain 2D adaptive multiple subtraction can better separate primaries and multiples than FISTA based time-offset domain 2D adaptive multiple subtraction. Furthermore, we introduce FISTA based parabolic Radon domain 2D adaptive multiple subtraction into the parabolic Radon domain hybrid demultiple method to improve its computation

  18. Internal jugular pressure increases during parabolic flight.

    Science.gov (United States)

    Martin, David S; Lee, Stuart M C; Matz, Timothy P; Westby, Christian M; Scott, Jessica M; Stenger, Michael B; Platts, Steven H

    2016-12-01

    One hypothesized contributor to vision changes experienced by >75% of International Space Station astronauts is elevated intracranial pressure (ICP). While no definitive data yet exist, elevated ICP might be secondary to the microgravity-induced cephalad fluid shift, resulting in venous congestion (overfilling and distension) and inhibition of cerebrospinal and lymphatic fluid drainage from the skull. The objective of this study was to measure internal jugular venous pressure (IJVP) during normo- and hypo-gravity as an index of venous congestion. IJVP was measured noninvasively using compression sonography at rest during end-expiration in 11 normal, healthy subjects (3 M, 8 F) during normal gravity (1G; supine) and weightlessness (0G; seated) produced by parabolic flight. IJVP also was measured in two subjects during parabolas approximating Lunar (1/6G) and Martian gravity (1/3G). Finally, IJVP was measured during increased intrathoracic pressure produced using controlled Valsalva maneuvers. IJVP was higher in 0G than 1G (23.9 ± 5.6 vs. 9.9 ± 5.1 mmHg, mean ± SD P < 0.001) in all subjects, and IJVP increased as gravity levels decreased in two subjects. Finally, IJVP was greater in 0G than 1G at all expiration pressures (P < 0.01). Taken together, these data suggest that IJVP is elevated during acute exposure to reduced gravity and may be elevated further by conditions that increase intrathoracic pressure, a strong modulator of central venous pressure and IJVP However, whether elevated IJVP, and perhaps consequent venous congestion, observed during acute microgravity exposure contribute to vision changes during long-duration spaceflight is yet to be determined. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

  19. Molten salt parabolic trough system with synthetic oil preheating

    Science.gov (United States)

    Yuasa, Minoru; Hino, Koichi

    2017-06-01

    Molten salt parabolic trough system (MSPT), which can heat the heat transfer fluid (HTF) to 550 °C has a better performance than a synthetic oil parabolic trough system (SOPT), which can heat the HTF to 400 °C or less. The utilization of HTF at higher temperature in the parabolic trough system is able to realize the design of a smaller size of storage tank and higher heat to electricity conversion efficiency. However, with MSPT there is a great amount of heat loss at night so it is necessary to circulate the HTF at a high temperature of about 290 °C in order to prevent solidification. A new MSPT concept with SOPT preheating (MSSOPT) has been developed to reduce the heat loss at night. In this paper, the MSSOPT system, its performance by steady state analysis and annual performance analysis are introduced.

  20. Interaction Potential between Parabolic Rotator and an Outside Particle

    Directory of Open Access Journals (Sweden)

    Dan Wang

    2014-01-01

    Full Text Available At micro/nanoscale, the interaction potential between parabolic rotator and a particle located outside the rotator is studied on the basis of the negative exponential pair potential 1/Rn between particles. Similar to two-dimensional curved surfaces, we confirm that the potential of the three-dimensional parabolic rotator and outside particle can also be expressed as a unified form of curvatures; that is, it can be written as the function of curvatures. Furthermore, we verify that the driving forces acting on the particle may be induced by the highly curved micro/nano-parabolic rotator. Curvatures and the gradient of curvatures are the essential elements forming the driving forces. Through the idealized numerical experiments, the accuracy of the curvature-based potential is preliminarily proved.

  1. Graphene Nanoribbon Conductance Model in Parabolic Band Structure

    Directory of Open Access Journals (Sweden)

    Mohammad Taghi Ahmadi

    2010-01-01

    Full Text Available Many experimental measurements have been done on GNR conductance. In this paper, analytical model of GNR conductance is presented. Moreover, comparison with published data which illustrates good agreement between them is studied. Conductance of GNR as a one-dimensional device channel with parabolic band structures near the charge neutrality point is improved. Based on quantum confinement effect, the conductance of GNR in parabolic part of the band structure, also the temperature-dependent conductance which displays minimum conductance near the charge neutrality point are calculated. Graphene nanoribbon (GNR with parabolic band structure near the minimum band energy terminates Fermi-Dirac integral base method on band structure study. While band structure is parabola, semiconducting GNRs conductance is a function of Fermi-Dirac integral which is based on Maxwell approximation in nondegenerate limit especially for a long channel.

  2. First Middle East Aircraft Parabolic Flights for ISU Participant Experiments

    Science.gov (United States)

    Pletser, Vladimir; Frischauf, Norbert; Cohen, Dan; Foster, Matthew; Spannagel, Ruven; Szeszko, Adam; Laufer, Rene

    2017-02-01

    Aircraft parabolic flights are widely used throughout the world to create microgravity environment for scientific and technology research, experiment rehearsal for space missions, and for astronaut training before space flights. As part of the Space Studies Program 2016 of the International Space University summer session at the Technion - Israel Institute of Technology, Haifa, Israel, a series of aircraft parabolic flights were organized with a glider in support of departmental activities on `Artificial and Micro-gravity' within the Space Sciences Department. Five flights were organized with manoeuvres including several parabolas with 5 to 6 s of weightlessness, bank turns with acceleration up to 2 g and disorientation inducing manoeuvres. Four demonstration experiments and two experiments proposed by SSP16 participants were performed during the flights by on board operators. This paper reports on the microgravity experiments conducted during these parabolic flights, the first conducted in the Middle East for science and pedagogical experiments.

  3. Analysis and conceptual design of a lunar radiator parabolic shade

    Science.gov (United States)

    Ewert, Michael K.; Clark, Craig S.

    1991-01-01

    On the moon, the available heat sink temperature for a vertical unshaded radiator at the equator is 322 K. A method of reducing this heat sink temperature using a parabolic trough shading device was investigated. A steady state heat balance was performed to predict the available heat sink temperature. The effect of optical surface properties on system performance was investigated. Various geometric configurations were also evaluated. A flexible shade conceptual design is presented which greatly reduces the weight and stowed volume of the system. The concept makes use of the natural catenary shape assumed by a flexible material when supported at two points. The catenary shape is very near parabolic. The lunar radiator parabolic shade design presented integrates the energy collection and rejection of a solar dynamic power cycle with the moderate temperature waste heat rejection of a lunar habitat.

  4. First Middle East Aircraft Parabolic Flights for ISU Participant Experiments

    Science.gov (United States)

    Pletser, Vladimir; Frischauf, Norbert; Cohen, Dan; Foster, Matthew; Spannagel, Ruven; Szeszko, Adam; Laufer, Rene

    2017-06-01

    Aircraft parabolic flights are widely used throughout the world to create microgravity environment for scientific and technology research, experiment rehearsal for space missions, and for astronaut training before space flights. As part of the Space Studies Program 2016 of the International Space University summer session at the Technion - Israel Institute of Technology, Haifa, Israel, a series of aircraft parabolic flights were organized with a glider in support of departmental activities on `Artificial and Micro-gravity' within the Space Sciences Department. Five flights were organized with manoeuvres including several parabolas with 5 to 6 s of weightlessness, bank turns with acceleration up to 2 g and disorientation inducing manoeuvres. Four demonstration experiments and two experiments proposed by SSP16 participants were performed during the flights by on board operators. This paper reports on the microgravity experiments conducted during these parabolic flights, the first conducted in the Middle East for science and pedagogical experiments.

  5. Real Parabolic Vector Bundles over a Real Curve

    Indian Academy of Sciences (India)

    Sanjay Amrutiya

    2014-02-01

    We define real parabolic structures on real vector bundles over a real curve. Let $(X, _X)$ be a real curve, and let $S\\subset X$ be a non-empty finite subset of such that $_X(S) = S$. Let ≥ 2 be an integer. We construct an -fold cyclic cover : $Y→ X$ in the category of real curves, ramified precisely over each point of , and with the property that for any element of the Galois group , and any $y\\in Y$, one has $_Y(gy) = g^{-1}_Y(y)$. We established an equivalence between the category of real parabolic vector bundles on $(X,_X)$ with real parabolic structure over , all of whose weights are integral multiples of 1/, and the category of real -equivariant vector bundles on $(Y, _Y)$.

  6. Federal technology alert. Parabolic-trough solar water heating

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    Parabolic-trough solar water heating is a well-proven renewable energy technology with considerable potential for application at Federal facilities. For the US, parabolic-trough water-heating systems are most cost effective in the Southwest where direct solar radiation is high. Jails, hospitals, barracks, and other facilities that consistently use large volumes of hot water are particularly good candidates, as are facilities with central plants for district heating. As with any renewable energy or energy efficiency technology requiring significant initial capital investment, the primary condition that will make a parabolic-trough system economically viable is if it is replacing expensive conventional water heating. In combination with absorption cooling systems, parabolic-trough collectors can also be used for air-conditioning. Industrial Solar Technology (IST) of Golden, Colorado, is the sole current manufacturer of parabolic-trough solar water heating systems. IST has an Indefinite Delivery/Indefinite Quantity (IDIQ) contract with the Federal Energy Management Program (FEMP) of the US Department of Energy (DOE) to finance and install parabolic-trough solar water heating on an Energy Savings Performance Contract (ESPC) basis for any Federal facility that requests it and for which it proves viable. For an ESPC project, the facility does not pay for design, capital equipment, or installation. Instead, it pays only for guaranteed energy savings. Preparing and implementing delivery or task orders against the IDIQ is much simpler than the standard procurement process. This Federal Technology Alert (FTA) of the New Technology Demonstration Program is one of a series of guides to renewable energy and new energy-efficient technologies.

  7. Focusing of Intense Laser via Parabolic Plasma Concave Surface

    Science.gov (United States)

    Zhou, Weimin; Gu, Yuqiu; Wu, Fengjuan; Zhang, Zhimeng; Shan, Lianqiang; Cao, Leifeng; Zhang, Baohan

    2015-12-01

    Since laser intensity plays an important role in laser plasma interactions, a method of increasing laser intensity - focusing of an intense laser via a parabolic plasma concave surface - is proposed and investigated by three-dimensional particle-in-cell simulations. The geometric focusing via a parabolic concave surface and the temporal compression of high harmonics increased the peak intensity of the laser pulse by about two orders of magnitude. Compared with the improvement via laser optics approaches, this scheme is much more economic and appropriate for most femtosecond laser facilities. supported by National Natural Science Foundation of China (Nos. 11174259, 11175165), and the Dual Hundred Foundation of China Academy of Engineering Physics

  8. Well-posedness of nonlocal parabolic differential problems with dependent operators.

    Science.gov (United States)

    Ashyralyev, Allaberen; Hanalyev, Asker

    2014-01-01

    The nonlocal boundary value problem for the parabolic differential equation v'(t) + A(t)v(t) = f(t) (0 ≤ t ≤ T), v(0) = v(λ) + φ, 0 parabolic equations with dependent coefficients are established.

  9. On the regularity of optimal control for a parabolic system of order 2m

    Directory of Open Access Journals (Sweden)

    Ornella Fiodo

    1992-05-01

    Full Text Available An optimal control problem for a parabolic operator of order 2m with the boundary conditions containing the control is considered. A regularity theorem for the parabolic problem and the regularity of the optimal control is proved.

  10. Phosphodiesterase 11A (PDE11A), Enriched in Ventral Hippocampus Neurons, is Required for Consolidation of Social but not Nonsocial Memories in Mice.

    Science.gov (United States)

    Hegde, Shweta; Capell, Will R; Ibrahim, Baher A; Klett, Jennifer; Patel, Neema S; Sougiannis, Alexander T; Kelly, Michy P

    2016-11-01

    The capacity to form long-lasting social memories is critical to our health and survival. cAMP signaling in the ventral hippocampal formation (VHIPP) appears to be required for social memory formation, but the phosphodiesterase (PDE) involved remains unknown. Previously, we showed that PDE11A, which degrades cAMP and cGMP, is preferentially expressed in CA1 and subiculum of the VHIPP. Here, we determine whether PDE11A is expressed in neurons where it could directly influence synaptic plasticity and whether expression is required for the consolidation and/or retrieval of social memories. In CA1, and possibly CA2, PDE11A4 is expressed throughout neuronal cell bodies, dendrites (stratum radiatum), and axons (fimbria), but not astrocytes. Unlike PDE2A, PDE9A, or PDE10A, PDE11A4 expression begins very low at postnatal day 7 (P7) and dramatically increases until P28, at which time it stabilizes to young adult levels. This expression pattern is consistent with the fact that PDE11A is required for social long-term memory (LTM) formation during adolescence and adulthood. Male and female PDE11 knockout (KO) mice show normal short-term memory (STM) for social odor recognition (SOR) and social transmission of food preference (STFP), but no LTM 24 h post training. Importantly, PDE11A KO mice show normal LTM for nonsocial odor recognition. Deletion of PDE11A may impair memory consolidation by impairing requisite protein translation in the VHIPP. Relative to WT littermates, PDE11A KO mice show reduced expression of RSK2 and lowered phosphorylation of S6 (pS6-235/236). Together, these data suggest PDE11A is selectively required for the proper consolidation of recognition and associative social memories.

  11. Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors

    Science.gov (United States)

    Temkitthawon, Prapapan; Hinds, Thomas R.; Beavo, Joseph A.; Viyoch, Jarupa; Suwanborirux, Khanit; Pongamornkul, Wittaya; Sawasdee, Pattara; Ingkaninan, Kornkanok

    2014-01-01

    Aim of the study A number of medicinal plants are used in traditional medicine to treat erectile dysfunction. Since cyclic nucleotide PDEs inhibitors underlie several current treatments for this condition, we sought to show whether these plants might contain substantial amounts of PDE5 inhibitors. Materials and methods Forty one plant extracts and eight 7-methoxyflavones from Kaempferia parviflora Wall. ex Baker were screened for PDE5 and PDE6 inhibitory activities using the two-step radioactive assay. The PDE5 and PDE6 were prepared from mice lung and chicken retinas, respectively. All plant extracts were tested at 50 μg/ml whereas the pure compounds were tested at 10 μM. Results From forty one plant extracts tested, four showed the PDE5 inhibitory effect. The chemical constituents isolated from rhizomes of Kaempferia parviflora were further investigated on inhibitory activity against PDE5 and PDE6. The results showed that 7-methoxyflavones from this plant showed inhibition toward both enzymes. The most potent PDE5 inhibitor was 5,7-dimethoxyflavone (IC50 = 10.64 ± 2.09 μM, selectivity on PDE5 over PDE6 = 3.71). Structure activity relationship showed that the methoxyl group at C-5 position of 7-methoxyflavones was necessary for PDE5 inhibition. Conclusions Kaempferia parviflora rhizome extract and its 7-methoxyflavone constituents had moderate inhibitory activity against PDE5. This finding provides an explanation for enhancing sexual performance in the traditional use of Kaempferia parviflora. Moreover, 5,7-dimethoxyflavones should make a useful lead compound to further develop clinically efficacious PDE5 inhibitors. PMID:21884777

  12. Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors.

    Science.gov (United States)

    Temkitthawon, Prapapan; Hinds, Thomas R; Beavo, Joseph A; Viyoch, Jarupa; Suwanborirux, Khanit; Pongamornkul, Wittaya; Sawasdee, Pattara; Ingkaninan, Kornkanok

    2011-10-11

    A number of medicinal plants are used in traditional medicine to treat erectile dysfunction. Since cyclic nucleotide PDEs inhibitors underlie several current treatments for this condition, we sought to show whether these plants might contain substantial amounts of PDE5 inhibitors. Forty one plant extracts and eight 7-methoxyflavones from Kaempferia parviflora Wall. ex Baker were screened for PDE5 and PDE6 inhibitory activities using the two-step radioactive assay. The PDE5 and PDE6 were prepared from mice lung and chicken retinas, respectively. All plant extracts were tested at 50 μg/ml whereas the pure compounds were tested at 10 μM. From forty one plant extracts tested, four showed the PDE5 inhibitory effect. The chemical constituents isolated from rhizomes of Kaempferia parviflora were further investigated on inhibitory activity against PDE5 and PDE6. The results showed that 7-methoxyflavones from this plant showed inhibition toward both enzymes. The most potent PDE5 inhibitor was 5,7-dimethoxyflavone (IC(50) = 10.64 ± 2.09 μM, selectivity on PDE5 over PDE6 = 3.71). Structure activity relationship showed that the methoxyl group at C-5 position of 7-methoxyflavones was necessary for PDE5 inhibition. Kaempferia parviflora rhizome extract and its 7-methoxyflavone constituents had moderate inhibitory activity against PDE5. This finding provides an explanation for enhancing sexual performance in the traditional use of Kaempferia parviflora. Moreover, 5,7-dimethoxyflavones should make a useful lead compound to further develop clinically efficacious PDE5 inhibitors. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  13. Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket.

    Science.gov (United States)

    Yoshikawa, Masato; Hitaka, Takenori; Hasui, Tomoaki; Fushimi, Makoto; Kunitomo, Jun; Kokubo, Hironori; Oki, Hideyuki; Nakashima, Kosuke; Taniguchi, Takahiko

    2016-08-15

    Utilizing structure-based drug design techniques, we designed and synthesized phosphodiesterase 10A (PDE10A) inhibitors based on pyridazin-4(1H)-one. These compounds can interact with Tyr683 in the PDE10A selectivity pocket. Pyridazin-4(1H)-one derivative 1 was linked with a benzimidazole group through an alkyl spacer to interact with the OH of Tyr683 and fill the PDE10A selectivity pocket. After optimizing the linker length, we identified 1-(cyclopropylmethyl)-5-[3-(1-methyl-1H-benzimidazol-2-yl)propoxy]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (16f) as having highly potent PDE10A inhibitory activity (IC50=0.76nM) and perfect selectivity against other PDEs (>13,000-fold, IC50=>10,000nM). The crystal structure of 16f bound to PDE10A revealed that the benzimidazole moiety was located deep within the PDE10A selectivity pocket and interacted with Tyr683. Additionally, a bidentate interaction existed between the 5-alkoxypyridazin-4(1H)-one moiety and the conserved Gln716 present in all PDEs.

  14. The Discovery of a Novel Phosphodiesterase (PDE) 4B-preferring Radioligand for Positron Emission Tomography (PET) Imaging.

    Science.gov (United States)

    Zhang, Lei; Chen, Laigao; Beck, Elizabeth M; Chappie, Thomas A; Coelho, Richard V; Doran, Shawn D; Fan, Kuo-Hsien; Humphrey, John M; Hughes, Zoe; Kuszpit, Kyle; Lachapelle, Erik A; Lazzaro, John T; Mather, Robert J; Patel, Nandini C; Skaddan, Marc B; Sciabola, Simone; Verhoest, Patrick R; Young, Joseph Michael; Zasadny, Kenneth; Villalobos, Anabella

    2017-09-28

    As part of our effort in identifying PDE4B-preferring inhibitors for the treatment of central nervous system (CNS) disorders, we sought to identify a positron emission tomography (PET) ligand to enable target occupancy measurement in vivo. Through a systematic and cost-effective PET discovery process, involving expression level (Bmax) and bio-distribution determination, a PET-specific structure-activity relationship (SAR) effort, and specific binding assessment using a LC-MS/MS "cold tracer" method, we have identified 8 (PF-06445974) as a promising PET lead. Compound 8 has exquisite potency at PDE4B, good selectivity over PDE4D, excellent brain permeability, and a high level of specific binding in the "cold tracer" study. In subsequent non-human primate (NHP) PET imaging studies, [18F]8 showed rapid brain uptake and high target specificity, indicating that [18F]8 is a promising PDE4B-preferring radioligand for clinical PET imaging.

  15. Hyperprolactinemia contributes to reproductive deficit in male rats chronically administered PDE5 inhibitors (sildenafil and tadalafil and opioid (tramadol

    Directory of Open Access Journals (Sweden)

    V.U. Nna

    2016-09-01

    Conclusion: Serum prolactin concentration correlated negatively with male reproductive hormones and may play a major role in reproductive deficits associated with chronic use of PDE5 inhibitors and opioids.

  16. Toward Interoperable Mesh, Geometry and Field Components for PDE Simulation Development

    Energy Technology Data Exchange (ETDEWEB)

    Chand, K K; Diachin, L F; Li, X; Ollivier-Gooch, C; Seol, E S; Shephard, M; Tautges, T; Trease, H

    2005-07-11

    Mesh-based PDE simulation codes are becoming increasingly sophisticated and rely on advanced meshing and discretization tools. Unfortunately, it is still difficult to interchange or interoperate tools developed by different communities to experiment with various technologies or to develop new capabilities. To address these difficulties, we have developed component interfaces designed to support the information flow of mesh-based PDE simulations. We describe this information flow and discuss typical roles and services provided by the geometry, mesh, and field components of the simulation. Based on this delineation for the roles of each component, we give a high-level description of the abstract data model and set of interfaces developed by the Department of Energy's Interoperable Tools for Advanced Petascale Simulation (ITAPS) center. These common interfaces are critical to our interoperability goal, and we give examples of several services based upon these interfaces including mesh adaptation and mesh improvement.

  17. PERSEPSI PENGOLAH DATA TERHADAP EFEKTIVITAS PDE HOTEL BERBINTANG DI KOTA DENPASAR

    Directory of Open Access Journals (Sweden)

    I KETUT SUWARTHA

    2010-07-01

    Full Text Available The development of information technology provides more expectations for the businessman, spesifically in the hotel sector. Nevertheless, in it’s implementation raise expectation gap between the user of the information and data processing in the Electronic Data Processing (PDE. The objective of this research is to find out the effectivity and dimension that should be improved on the side of data processing perception in the Electronic Data Processing (PDE of  star hotels  in Denpasar. The data collected by using questionnaire and interview and the data analysis technique used in this research is quantitative analysis technique. The conclusions from the analysis are (1 data processing perception included in the category of very effective by 81.64%, (2 there are three dimensions which needs more attention and improved, namely time dimension, report variation dimension or out put, information quality dimension.

  18. Mesh dependence in PDE-constrained optimisation an application in tidal turbine array layouts

    CERN Document Server

    Schwedes, Tobias; Funke, Simon W; Piggott, Matthew D

    2017-01-01

    This book provides an introduction to PDE-constrained optimisation using finite elements and the adjoint approach. The practical impact of the mathematical insights presented here are demonstrated using the realistic scenario of the optimal placement of marine power turbines, thereby illustrating the real-world relevance of best-practice Hilbert space aware approaches to PDE-constrained optimisation problems. Many optimisation problems that arise in a real-world context are constrained by partial differential equations (PDEs). That is, the system whose configuration is to be optimised follows physical laws given by PDEs. This book describes general Hilbert space formulations of optimisation algorithms, thereby facilitating optimisations whose controls are functions of space. It demonstrates the importance of methods that respect the Hilbert space structure of the problem by analysing the mathematical drawbacks of failing to do so. The approaches considered are illustrated using the optimisation problem arisin...

  19. Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia.

    Science.gov (United States)

    Deng, Xiangdong; Takaki, Hiromi; Wang, Lixiang; Kuroki, Tosihide; Nakahara, Tatsuo; Hashimoto, Kijiro; Ninomiya, Hideaki; Arinami, Tadao; Inada, Toshiya; Ujike, Hiroshi; Itokawa, Masanari; Tochigi, Mamoru; Watanabe, Yuichiro; Someya, Toshiyuki; Kunugi, Hiroshi; Iwata, Nakao; Ozaki, Norio; Shibata, Hiroki; Fukumaki, Yasuyuki

    2011-12-01

    As schizophrenia-like symptoms are produced by administration of phencyclidine (PCP), a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, PCP-responsive genes could be involved in the pathophysiology of schizophrenia. We injected PCP to Wistar rats and isolated five different parts of the brain in 1 and 4 hr after the injection. We analyzed the gene expression induced by the PCP treatment of these tissues using the AGILENT rat cDNA microarray system. We observed changes in expression level in 90 genes and 21 ESTs after the treatment. Out of the 10 genes showing >2-fold expressional change evaluated by qRT-PCR, we selected 7 genes as subjects for the locus-wide association study to identify susceptibility genes for schizophrenia in the Japanese population. In haplotype analysis, significant associations were detected in combinations of two SNPs of BTG2 (P = 1.4 × 10(-6) ), PDE4A (P = 1.4 × 10(-6) ), and PLAT (P = 1 × 10(-3) ), after false discovery rate (FDR) correction. Additionally, we not only successfully replicated the haplotype associations in PDE4A (P = 6.8 × 10(-12) ) and PLAT (P = 0.015), but also detected single-point associations of one SNP in PDE4A (P = 0.0068) and two SNPs in PLAT (P = 0.0260 and 0.0104) in another larger sample set consisting of 2,224 cases and 2,250 controls. These results indicate that PDE4A and PLAT may be susceptibility genes for schizophrenia in the Japanese population.

  20. Relaxation Methods for Hyperbolic PDE Mixed-Integer Optimal Control Problems

    OpenAIRE

    Hante, Falk M.

    2015-01-01

    We extend the convergence analysis for methods solving PDE-constrained optimal control problems containing both discrete and continuous control decisions based on relaxation and rounding strategies to the class of first order semilinear hyperbolic systems in one space dimension. The results are obtained by novel a-priori estimates for the size of the relaxation gap based on the characteristic flow, fixed-point arguments and particular regularity theory for such mixed-integer control problems....

  1. Optimality conditions for the numerical solution of optimization problems with PDE constraints :

    Energy Technology Data Exchange (ETDEWEB)

    Aguilo Valentin, Miguel Alejandro; Ridzal, Denis

    2014-03-01

    A theoretical framework for the numerical solution of partial di erential equation (PDE) constrained optimization problems is presented in this report. This theoretical framework embodies the fundamental infrastructure required to e ciently implement and solve this class of problems. Detail derivations of the optimality conditions required to accurately solve several parameter identi cation and optimal control problems are also provided in this report. This will allow the reader to further understand how the theoretical abstraction presented in this report translates to the application.

  2. Invariant Measure for the Markov Process Corresponding to a PDE System

    Institute of Scientific and Technical Information of China (English)

    Fu Bao XI

    2005-01-01

    In this paper, we consider the Markov process (X∈(t), Z∈(t)) corresponding to a weakly coupled elliptic PDE system with a small parameter ∈> 0. We first prove that (X∈(t), Z∈(t)) has the Feller continuity by the coupling method, and then prove that (X∈(t), Z∈(t)) has an invariant measure the small parameter ∈ tends to zero.

  3. The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin

    OpenAIRE

    DiPilato, Lisa M.; Ahmad, Faiyaz; Harms, Matthew; Seale, Patrick; Manganiello, Vincent; Birnbaum, Morris J.

    2015-01-01

    Inhibition of adipocyte lipolysis by insulin is important for whole-body energy homeostasis; its disruption has been implicated as contributing to the development of insulin resistance and type 2 diabetes mellitus. The main target of the antilipolytic action of insulin is believed to be phosphodiesterase 3B (PDE3B), whose phosphorylation by Akt leads to accelerated degradation of the prolipolytic second messenger cyclic AMP (cAMP). To test this hypothesis genetically, brown adipocytes lacking...

  4. PDE Surface Generation with Combined Closed and Non-Closed Form Solutions

    Institute of Scientific and Technical Information of China (English)

    Jian-Jun Zhang; Li-Hua You

    2004-01-01

    Partial differential equations (PDEs) combined with suitably chosen boundary conditions are effective in creating free form surfaces. In this paper, a fourth order partial differential equation and boundary conditions up to tangential continuity are introduced. The general solution is divided into a closed form solution and a non-closed form one leading to a mixed solution to the PDE. The obtained solution is applied to a number of surface modelling examples including glass shape design, vase surface creation and arbitrary surface representation.

  5. Low-complexity PDE-based approach for automatic microarray image processing.

    Science.gov (United States)

    Belean, Bogdan; Terebes, Romulus; Bot, Adrian

    2015-02-01

    Microarray image processing is known as a valuable tool for gene expression estimation, a crucial step in understanding biological processes within living organisms. Automation and reliability are open subjects in microarray image processing, where grid alignment and spot segmentation are essential processes that can influence the quality of gene expression information. The paper proposes a novel partial differential equation (PDE)-based approach for fully automatic grid alignment in case of microarray images. Our approach can handle image distortions and performs grid alignment using the vertical and horizontal luminance function profiles. These profiles are evolved using a hyperbolic shock filter PDE and then refined using the autocorrelation function. The results are compared with the ones delivered by state-of-the-art approaches for grid alignment in terms of accuracy and computational complexity. Using the same PDE formalism and curve fitting, automatic spot segmentation is achieved and visual results are presented. Considering microarray images with different spots layouts, reliable results in terms of accuracy and reduced computational complexity are achieved, compared with existing software platforms and state-of-the-art methods for microarray image processing.

  6. A parabolic singular perturbation problem with an internal layer

    NARCIS (Netherlands)

    Grasman, J.; Shih, S.D.

    2004-01-01

    A method is presented to approximate with singular perturbation methods a parabolic differential equation for the quarter plane with a discontinuity at the corner. This discontinuity gives rise to an internal layer. It is necessary to match the local solution in this layer with the one in a corner l

  7. Long-term average performance benefits of parabolic trough improvements

    Energy Technology Data Exchange (ETDEWEB)

    Gee, R.; Gaul, H.W.; Kearney, D.; Rabl, A.

    1980-03-01

    Improved parabolic trough concentrating collectors will result from better design, improved fabrication techniques, and the development and utilization of improved materials. The difficulty of achieving these improvements varies as does their potential for increasing parabolic trough performance. The purpose of this analysis is to quantify the relative merit of various technology advancements in improving the long-term average performance of parabolic trough concentrating collectors. The performance benefits of improvements are determined as a function of operating temperature for north-south, east-west, and polar mounted parabolic troughs. The results are presented graphically to allow a quick determination of the performance merits of particular improvements. Substantial annual energy gains are shown to be attainable. Of the improvements evaluated, the development of stable back-silvered glass reflective surfaces offers the largest performance gain for operating temperatures below 150/sup 0/C. Above 150/sup 0/C, the development of trough receivers that can maintain a vacuum is the most significant potential improvement. The reduction of concentrator slope errors also has a substantial performance benefit at high operating temperatures.

  8. Proton driven plasma wakefield generation in a parabolic plasma channel

    Science.gov (United States)

    Golian, Y.; Dorranian, D.

    2016-11-01

    An analytical model for the interaction of charged particle beams and plasma for a wakefield generation in a parabolic plasma channel is presented. In the suggested model, the plasma density profile has a minimum value on the propagation axis. A Gaussian proton beam is employed to excite the plasma wakefield in the channel. While previous works investigated on the simulation results and on the perturbation techniques in case of laser wakefield accelerations for a parabolic channel, we have carried out an analytical model and solved the accelerating field equation for proton beam in a parabolic plasma channel. The solution is expressed by Whittaker (hypergeometric) functions. Effects of plasma channel radius, proton bunch parameters and plasma parameters on the accelerating processes of proton driven plasma wakefield acceleration are studied. Results show that the higher accelerating fields could be generated in the PWFA scheme with modest reductions in the bunch size. Also, the modest increment in plasma channel radius is needed to obtain maximum accelerating gradient. In addition, the simulations of longitudinal and total radial wakefield in parabolic plasma channel are presented using LCODE. It is observed that the longitudinal wakefield generated by the bunch decreases with the distance behind the bunch while total radial wakefield increases with the distance behind the bunch.

  9. Improved Green's function parabolic equation method for atmospheric sound propagation

    NARCIS (Netherlands)

    Salomons, E.M.

    1998-01-01

    The numerical implementation of the Green's function parabolic equation (GFPE) method for atmospheric sound propagation is discussed. Four types of numerical errors are distinguished: (i) errors in the forward Fourier transform; (ii) errors in the inverse Fourier transform; (iii) errors in the refra

  10. The ellipse in parabolic motion: An undergraduate experiment

    Science.gov (United States)

    Carrillo-Bernal, M. A.; Mancera-Piña, P. E.; Cerecedo-Núñez, H. H.; Padilla-Sosa, P.; Núñez-Yépez, H. N.; Salas-Brito, A. L.

    2014-04-01

    We present a simple method of experimentally studying the elliptic shape of the joined apices of parabolic projectile trajectories in the undergraduate laboratory. The experimental data agrees well with theoretical results, and we find that this experiment provides an interesting twist to the venerable undergraduate experiment on projectile motion.

  11. MULTIGRID FOR THE MORTAR FINITE ELEMENT FOR PARABOLIC PROBLEM

    Institute of Scientific and Technical Information of China (English)

    Xue-jun Xu; Jin-ru Chen

    2003-01-01

    In this paper, a mortar finite element method for parabolic problem is presented. Multigrid method is used for solving the resulting discrete system. It is shown that the multigrid method is optimal, I.e, the convergence rate is independent of the mesh size L and the time step parameter т.

  12. Boundary control of parabolic systems - Finite-element approximation

    Science.gov (United States)

    Lasiecka, I.

    1980-01-01

    The finite element approximation of a Dirichlet type boundary control problem for parabolic systems is considered. An approach based on the direct approximation of an input-output semigroup formula is applied. Error estimates are derived for optimal state and optimal control, and it is noted that these estimates are actually optimal with respect to the approximation theoretic properties.

  13. Parabolic vortex equations and instantons of infinite energy

    Science.gov (United States)

    Biquard, Olivier; García-Prada, Oscar

    1997-02-01

    We study the vortex equations on parabolic bundles over a Riemann surface and prove a Hitchin-Kobayashi-type correspondence relating the existence of solutions to a certain stability condition. This is achieved by translating our problem into a four-dimensional one, via dimensional reduction arguments. In return we obtain examples of instantons of infinite energy.

  14. Negative Trions Trapped by a Spherical Parabolic Quantum Dot

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    In this paper, a negatively charged exciton trapped by a spherical parabolic quantum dot has been investigated. The energy spectra of low-lying states are calculated by means of matrix diagonalization. The important feature of the low-lying states of the negatively charged excitons in a spherical quantum dot is obtained via an analysis of the energy spectra.

  15. On an algorithm for solving parabolic and elliptic equations

    Science.gov (United States)

    D'Ascenzo, N.; Saveliev, V. I.; Chetverushkin, B. N.

    2015-08-01

    The present-day rapid growth of computer power, in particular, parallel computing systems of ultrahigh performance requires a new approach to the creation of models and solution algorithms for major problems. An algorithm for solving parabolic and elliptic equations is proposed. The capabilities of the method are demonstrated by solving astrophysical problems on high-performance computer systems with massive parallelism.

  16. Compactness of the commutators of parabolic singular integrals

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    In this paper,the authors prove that the commutator [b,T] of the parabolic singular integrals is a compact operator on Lp(Rn)(1 < p < ∞) if and only if b ∈ VMO(Rn,ρ).The result is substantial improvement and extension of some known results.

  17. Null controllability for a fourth order parabolic equation

    Institute of Scientific and Technical Information of China (English)

    YU Hang

    2009-01-01

    In the paper,the null interior controllability for a fourth order parabolic equation is obtained.The method Is based on Lebeau-Rabbiano inequality which is a quantitative unique continuation property for the sum of eigenfunctions of the Laplacian.

  18. The dynamics of parabolic flight: flight characteristics and passenger percepts.

    Science.gov (United States)

    Karmali, Faisal; Shelhamer, Mark

    2008-09-01

    Flying a parabolic trajectory in an aircraft is one of the few ways to create freefall on Earth, which is important for astronaut training and scientific research. Here we review the physics underlying parabolic flight, explain the resulting flight dynamics, and describe several counterintuitive findings, which we corroborate using experimental data. Typically, the aircraft flies parabolic arcs that produce approximately 25 seconds of freefall (0 g) followed by 40 seconds of enhanced force (1.8 g), repeated 30-60 times. Although passengers perceive gravity to be zero, in actuality acceleration, and not gravity, has changed, and thus we caution against the terms "microgravity" and "zero gravity. " Despite the aircraft trajectory including large (45°) pitch-up and pitch-down attitudes, the occupants experience a net force perpendicular to the floor of the aircraft. This is because the aircraft generates appropriate lift and thrust to produce the desired vertical and longitudinal accelerations, respectively, although we measured moderate (0.2 g) aft-ward accelerations during certain parts of these trajectories. Aircraft pitch rotation (average 3°/s) is barely detectable by the vestibular system, but could influence some physics experiments. Investigators should consider such details in the planning, analysis, and interpretation of parabolic-flight experiments.

  19. The fundamental solutions for fractional evolution equations of parabolic type

    Directory of Open Access Journals (Sweden)

    Mahmoud M. El-Borai

    2004-01-01

    Full Text Available The fundamental solutions for linear fractional evolution equations are obtained. The coefficients of these equations are a family of linear closed operators in the Banach space. Also, the continuous dependence of solutions on the initial conditions is studied. A mixed problem of general parabolic partial differential equations with fractional order is given as an application.

  20. Numerical and asymptotic aspects of parabolic cylinder functions

    NARCIS (Netherlands)

    Temme, N.M.

    2000-01-01

    Several uniform asymptotics expansions of the Weber parabolic cylinder functions are considered, one group in terms of elementary functions, another group in terms of Airy functions. Starting point for the discussion are asymptotic expansions given earlier by F.W.J. Olver. Some of his results are