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Sample records for nonlinear mixed-effects modeling

  1. Non-linear mixed-effects pharmacokinetic/pharmacodynamic modelling in NLME using differential equations

    DEFF Research Database (Denmark)

    Tornøe, Christoffer Wenzel; Agersø, Henrik; Madsen, Henrik

    2004-01-01

    The standard software for non-linear mixed-effect analysis of pharmacokinetic/phar-macodynamic (PK/PD) data is NONMEM while the non-linear mixed-effects package NLME is an alternative as tong as the models are fairly simple. We present the nlmeODE package which combines the ordinary differential...... equation (ODE) solver package odesolve and the non-Linear mixed effects package NLME thereby enabling the analysis of complicated systems of ODEs by non-linear mixed-effects modelling. The pharmacokinetics of the anti-asthmatic drug theophylline is used to illustrate the applicability of the nlme...

  2. A Multiphase Non-Linear Mixed Effects Model: An Application to Spirometry after Lung Transplantation

    Science.gov (United States)

    Rajeswaran, Jeevanantham; Blackstone, Eugene H.

    2014-01-01

    In medical sciences, we often encounter longitudinal temporal relationships that are non-linear in nature. The influence of risk factors may also change across longitudinal follow-up. A system of multiphase non-linear mixed effects model is presented to model temporal patterns of longitudinal continuous measurements, with temporal decomposition to identify the phases and risk factors within each phase. Application of this model is illustrated using spirometry data after lung transplantation using readily available statistical software. This application illustrates the usefulness of our flexible model when dealing with complex non-linear patterns and time varying coefficients. PMID:24919830

  3. A multilevel nonlinear mixed-effects approach to model growth in pigs

    DEFF Research Database (Denmark)

    Strathe, Anders Bjerring; Danfær, Allan Christian; Sørensen, H.

    2010-01-01

    Growth functions have been used to predict market weight of pigs and maximize return over feed costs. This study was undertaken to compare 4 growth functions and methods of analyzing data, particularly one that considers nonlinear repeated measures. Data were collected from an experiment with 40...... pigs maintained from birth to maturity and their BW measured weekly or every 2 wk up to 1,007 d. Gompertz, logistic, Bridges, and Lopez functions were fitted to the data and compared using information criteria. For each function, a multilevel nonlinear mixed effects model was employed because....... Furthermore, studies should consider adding continuous autoregressive process when analyzing nonlinear mixed models with repeated measures....

  4. A Nonlinear Mixed Effects Model for the Prediction of Natural Gas Consumption by Individual Customers

    Czech Academy of Sciences Publication Activity Database

    Brabec, Marek; Konár, Ondřej; Pelikán, Emil; Malý, Marek

    2008-01-01

    Roč. 24, č. 4 (2008), s. 659-678 ISSN 0169-2070 R&D Projects: GA AV ČR 1ET400300513 Institutional research plan: CEZ:AV0Z10300504 Keywords : individual gas consumption * nonlinear mixed effects model * ARIMAX * ARX * generalized linear mixed model * conditional modeling Subject RIV: JE - Non-nuclear Energetics, Energy Consumption ; Use Impact factor: 1.685, year: 2008

  5. Performance of nonlinear mixed effects models in the presence of informative dropout.

    Science.gov (United States)

    Björnsson, Marcus A; Friberg, Lena E; Simonsson, Ulrika S H

    2015-01-01

    Informative dropout can lead to bias in statistical analyses if not handled appropriately. The objective of this simulation study was to investigate the performance of nonlinear mixed effects models with regard to bias and precision, with and without handling informative dropout. An efficacy variable and dropout depending on that efficacy variable were simulated and model parameters were reestimated, with or without including a dropout model. The Laplace and FOCE-I estimation methods in NONMEM 7, and the stochastic simulations and estimations (SSE) functionality in PsN, were used in the analysis. For the base scenario, bias was low, less than 5% for all fixed effects parameters, when a dropout model was used in the estimations. When a dropout model was not included, bias increased up to 8% for the Laplace method and up to 21% if the FOCE-I estimation method was applied. The bias increased with decreasing number of observations per subject, increasing placebo effect and increasing dropout rate, but was relatively unaffected by the number of subjects in the study. This study illustrates that ignoring informative dropout can lead to biased parameters in nonlinear mixed effects modeling, but even in cases with few observations or high dropout rate, the bias is relatively low and only translates into small effects on predictions of the underlying effect variable. A dropout model is, however, crucial in the presence of informative dropout in order to make realistic simulations of trial outcomes.

  6. Probability of atrial fibrillation after ablation: Using a parametric nonlinear temporal decomposition mixed effects model.

    Science.gov (United States)

    Rajeswaran, Jeevanantham; Blackstone, Eugene H; Ehrlinger, John; Li, Liang; Ishwaran, Hemant; Parides, Michael K

    2018-01-01

    Atrial fibrillation is an arrhythmic disorder where the electrical signals of the heart become irregular. The probability of atrial fibrillation (binary response) is often time varying in a structured fashion, as is the influence of associated risk factors. A generalized nonlinear mixed effects model is presented to estimate the time-related probability of atrial fibrillation using a temporal decomposition approach to reveal the pattern of the probability of atrial fibrillation and their determinants. This methodology generalizes to patient-specific analysis of longitudinal binary data with possibly time-varying effects of covariates and with different patient-specific random effects influencing different temporal phases. The motivation and application of this model is illustrated using longitudinally measured atrial fibrillation data obtained through weekly trans-telephonic monitoring from an NIH sponsored clinical trial being conducted by the Cardiothoracic Surgery Clinical Trials Network.

  7. Effect of correlation on covariate selection in linear and nonlinear mixed effect models.

    Science.gov (United States)

    Bonate, Peter L

    2017-01-01

    The effect of correlation among covariates on covariate selection was examined with linear and nonlinear mixed effect models. Demographic covariates were extracted from the National Health and Nutrition Examination Survey III database. Concentration-time profiles were Monte Carlo simulated where only one covariate affected apparent oral clearance (CL/F). A series of univariate covariate population pharmacokinetic models was fit to the data and compared with the reduced model without covariate. The "best" covariate was identified using either the likelihood ratio test statistic or AIC. Weight and body surface area (calculated using Gehan and George equation, 1970) were highly correlated (r = 0.98). Body surface area was often selected as a better covariate than weight, sometimes as high as 1 in 5 times, when weight was the covariate used in the data generating mechanism. In a second simulation, parent drug concentration and three metabolites were simulated from a thorough QT study and used as covariates in a series of univariate linear mixed effects models of ddQTc interval prolongation. The covariate with the largest significant LRT statistic was deemed the "best" predictor. When the metabolite was formation-rate limited and only parent concentrations affected ddQTc intervals the metabolite was chosen as a better predictor as often as 1 in 5 times depending on the slope of the relationship between parent concentrations and ddQTc intervals. A correlated covariate can be chosen as being a better predictor than another covariate in a linear or nonlinear population analysis by sheer correlation These results explain why for the same drug different covariates may be identified in different analyses. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  8. Multilevel nonlinear mixed-effects models for the modeling of earlywood and latewood microfibril angle

    Science.gov (United States)

    Lewis Jordon; Richard F. Daniels; Alexander Clark; Rechun He

    2005-01-01

    Earlywood and latewood microfibril angle (MFA) was determined at I-millimeter intervals from disks at 1.4 meters, then at 3-meter intervals to a height of 13.7 meters, from 18 loblolly pine (Pinus taeda L.) trees grown in southeastern Texas. A modified three-parameter logistic function with mixed effects is used for modeling earlywood and latewood...

  9. Assessing robustness of designs for random effects parameters for nonlinear mixed-effects models.

    Science.gov (United States)

    Duffull, Stephen B; Hooker, Andrew C

    2017-12-01

    Optimal designs for nonlinear models are dependent on the choice of parameter values. Various methods have been proposed to provide designs that are robust to uncertainty in the prior choice of parameter values. These methods are generally based on estimating the expectation of the determinant (or a transformation of the determinant) of the information matrix over the prior distribution of the parameter values. For high dimensional models this can be computationally challenging. For nonlinear mixed-effects models the question arises as to the importance of accounting for uncertainty in the prior value of the variances of the random effects parameters. In this work we explore the influence of the variance of the random effects parameters on the optimal design. We find that the method for approximating the expectation and variance of the likelihood is of potential importance for considering the influence of random effects. The most common approximation to the likelihood, based on a first-order Taylor series approximation, yields designs that are relatively insensitive to the prior value of the variance of the random effects parameters and under these conditions it appears to be sufficient to consider uncertainty on the fixed-effects parameters only.

  10. Nonlinear mixed effects modelling approach in investigating phenobarbital pharmacokinetic interactions in epileptic patients.

    Science.gov (United States)

    Vučićević, Katarina; Jovanović, Marija; Golubović, Bojana; Kovačević, Sandra Vezmar; Miljković, Branislava; Martinović, Žarko; Prostran, Milica

    2015-02-01

    The present study aimed to establish population pharmacokinetic model for phenobarbital (PB), examining and quantifying the magnitude of PB interactions with other antiepileptic drugs concomitantly used and to demonstrate its use for individualization of PB dosing regimen in adult epileptic patients. In total 205 PB concentrations were obtained during routine clinical monitoring of 136 adult epilepsy patients. PB steady state concentrations were measured by homogeneous enzyme immunoassay. Nonlinear mixed effects modelling (NONMEM) was applied for data analyses and evaluation of the final model. According to the final population model, significant determinant of apparent PB clearance (CL/F) was daily dose of concomitantly given valproic acid (VPA). Typical value of PB CL/F for final model was estimated at 0.314 l/h. Based on the final model, co-therapy with usual VPA dose of 1000 mg/day, resulted in PB CL/F average decrease of about 25 %, while 2000 mg/day leads to an average 50 % decrease in PB CL/F. Developed population PB model may be used in estimating individual CL/F for adult epileptic patients and could be applied for individualizing dosing regimen taking into account dose-dependent effect of concomitantly given VPA.

  11. Nonlinear mixed effects modelling for the analysis of longitudinal body core temperature data in healthy volunteers.

    Science.gov (United States)

    Seng, Kok-Yong; Chen, Ying; Wang, Ting; Ming Chai, Adam Kian; Yuen Fun, David Chiok; Teo, Ya Shi; Sze Tan, Pearl Min; Ang, Wee Hon; Wei Lee, Jason Kai

    2016-04-01

    Many longitudinal studies have collected serial body core temperature (T c) data to understand thermal work strain of workers under various environmental and operational heat stress environments. This provides the opportunity for the development of mathematical models to analyse and forecast temporal T c changes across populations of subjects. Such models can reduce the need for invasive methods that continuously measure T c. This current work sought to develop a nonlinear mixed effects modelling framework to delineate the dynamic changes of T c and its association with a set of covariates of interest (e.g. heart rate, chest skin temperature), and the structure of the variability of T c in various longitudinal studies. Data to train and evaluate the model were derived from two laboratory investigations involving male soldiers who participated in either a 12 (N  =  18) or 15 km (N  =  16) foot march with varied clothing, load and heat acclimatisation status. Model qualification was conducted using nonparametric bootstrap and cross validation procedures. For cross validation, the trajectory of a new subject's T c was simulated via Bayesian maximum a posteriori estimation when using only the baseline T c or using the baseline T c as well as measured T c at the end of every work (march) phase. The final model described T c versus time profiles using a parametric function with its main parameters modelled as a sigmoid hyperbolic function of the load and/or chest skin temperature. Overall, T c predictions corresponded well with the measured data (root mean square deviation: 0.16 °C), and compared favourably with those provided by two recently published Kalman filter models.

  12. A general method to determine sampling windows for nonlinear mixed effects models with an application to population pharmacokinetic studies.

    Science.gov (United States)

    Foo, Lee Kien; McGree, James; Duffull, Stephen

    2012-01-01

    Optimal design methods have been proposed to determine the best sampling times when sparse blood sampling is required in clinical pharmacokinetic studies. However, the optimal blood sampling time points may not be feasible in clinical practice. Sampling windows, a time interval for blood sample collection, have been proposed to provide flexibility in blood sampling times while preserving efficient parameter estimation. Because of the complexity of the population pharmacokinetic models, which are generally nonlinear mixed effects models, there is no analytical solution available to determine sampling windows. We propose a method for determination of sampling windows based on MCMC sampling techniques. The proposed method attains a stationary distribution rapidly and provides time-sensitive windows around the optimal design points. The proposed method is applicable to determine sampling windows for any nonlinear mixed effects model although our work focuses on an application to population pharmacokinetic models. Copyright © 2012 John Wiley & Sons, Ltd.

  13. A Comparison of Two-Stage Approaches for Fitting Nonlinear Ordinary Differential Equation Models with Mixed Effects.

    Science.gov (United States)

    Chow, Sy-Miin; Bendezú, Jason J; Cole, Pamela M; Ram, Nilam

    2016-01-01

    Several approaches exist for estimating the derivatives of observed data for model exploration purposes, including functional data analysis (FDA; Ramsay & Silverman, 2005 ), generalized local linear approximation (GLLA; Boker, Deboeck, Edler, & Peel, 2010 ), and generalized orthogonal local derivative approximation (GOLD; Deboeck, 2010 ). These derivative estimation procedures can be used in a two-stage process to fit mixed effects ordinary differential equation (ODE) models. While the performance and utility of these routines for estimating linear ODEs have been established, they have not yet been evaluated in the context of nonlinear ODEs with mixed effects. We compared properties of the GLLA and GOLD to an FDA-based two-stage approach denoted herein as functional ordinary differential equation with mixed effects (FODEmixed) in a Monte Carlo (MC) study using a nonlinear coupled oscillators model with mixed effects. Simulation results showed that overall, the FODEmixed outperformed both the GLLA and GOLD across all the embedding dimensions considered, but a novel use of a fourth-order GLLA approach combined with very high embedding dimensions yielded estimation results that almost paralleled those from the FODEmixed. We discuss the strengths and limitations of each approach and demonstrate how output from each stage of FODEmixed may be used to inform empirical modeling of young children's self-regulation.

  14. Non-linear mixed effects modeling - from methodology and software development to driving implementation in drug development science.

    Science.gov (United States)

    Pillai, Goonaseelan Colin; Mentré, France; Steimer, Jean-Louis

    2005-04-01

    Few scientific contributions have made significant impact unless there was a champion who had the vision to see the potential for its use in seemingly disparate areas-and who then drove active implementation. In this paper, we present a historical summary of the development of non-linear mixed effects (NLME) modeling up to the more recent extensions of this statistical methodology. The paper places strong emphasis on the pivotal role played by Lewis B. Sheiner (1940-2004), who used this statistical methodology to elucidate solutions to real problems identified in clinical practice and in medical research and on how he drove implementation of the proposed solutions. A succinct overview of the evolution of the NLME modeling methodology is presented as well as ideas on how its expansion helped to provide guidance for a more scientific view of (model-based) drug development that reduces empiricism in favor of critical quantitative thinking and decision making.

  15. Nonlinear mixed effects modeling of gametocyte carriage in patients with uncomplicated malaria

    Directory of Open Access Journals (Sweden)

    Little Francesca

    2010-02-01

    Full Text Available Abstract Background Gametocytes are the sexual form of the malaria parasite and the main agents of transmission. While there are several factors that influence host infectivity, the density of gametocytes appears to be the best single measure that is related to the human host's infectivity to mosquitoes. Despite the obviously important role that gametocytes play in the transmission of malaria and spread of anti-malarial resistance, it is common to estimate gametocyte carriage indirectly based on asexual parasite measurements. The objective of this research was to directly model observed gametocyte densities over time, during the primary infection. Methods Of 447 patients enrolled in sulphadoxine-pyrimethamine therapeutic efficacy studies in South Africa and Mozambique, a subset of 103 patients who had no gametocytes pre-treatment and who had at least three non-zero gametocyte densities over the 42-day follow up period were included in this analysis. Results A variety of different functions were examined. A modified version of the critical exponential function was selected for the final model given its robustness across different datasets and its flexibility in assuming a variety of different shapes. Age, site, initial asexual parasite density (logged to the base 10, and an empirical patient category were the co-variates that were found to improve the model. Conclusions A population nonlinear modeling approach seems promising and produced a flexible function whose estimates were stable across various different datasets. Surprisingly, dihydrofolate reductase and dihydropteroate synthetase mutation prevalence did not enter the model. This is probably related to a lack of power (quintuple mutations n = 12, and informative censoring; treatment failures were withdrawn from the study and given rescue treatment, usually prior to completion of follow up.

  16. A nonlinear mixed-effects model for simultaneous smoothing and registration of functional data

    DEFF Research Database (Denmark)

    Raket, Lars Lau; Sommer, Stefan Horst; Markussen, Bo

    2014-01-01

    We consider misaligned functional data, where data registration is necessary for proper statistical analysis. This paper proposes to treat misalignment as a nonlinear random effect, which makes simultaneous likelihood inference for horizontal and vertical effects possible. By simultaneously fitti...

  17. An MCMC method for the evaluation of the Fisher information matrix for non-linear mixed effect models.

    Science.gov (United States)

    Riviere, Marie-Karelle; Ueckert, Sebastian; Mentré, France

    2016-10-01

    Non-linear mixed effect models (NLMEMs) are widely used for the analysis of longitudinal data. To design these studies, optimal design based on the expected Fisher information matrix (FIM) can be used instead of performing time-consuming clinical trial simulations. In recent years, estimation algorithms for NLMEMs have transitioned from linearization toward more exact higher-order methods. Optimal design, on the other hand, has mainly relied on first-order (FO) linearization to calculate the FIM. Although efficient in general, FO cannot be applied to complex non-linear models and with difficulty in studies with discrete data. We propose an approach to evaluate the expected FIM in NLMEMs for both discrete and continuous outcomes. We used Markov Chain Monte Carlo (MCMC) to integrate the derivatives of the log-likelihood over the random effects, and Monte Carlo to evaluate its expectation w.r.t. the observations. Our method was implemented in R using Stan, which efficiently draws MCMC samples and calculates partial derivatives of the log-likelihood. Evaluated on several examples, our approach showed good performance with relative standard errors (RSEs) close to those obtained by simulations. We studied the influence of the number of MC and MCMC samples and computed the uncertainty of the FIM evaluation. We also compared our approach to Adaptive Gaussian Quadrature, Laplace approximation, and FO. Our method is available in R-package MIXFIM and can be used to evaluate the FIM, its determinant with confidence intervals (CIs), and RSEs with CIs. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  18. A Nonlinear Mixed Effects Approach for Modeling the Cell-To-Cell Variability of Mig1 Dynamics in Yeast.

    Directory of Open Access Journals (Sweden)

    Joachim Almquist

    Full Text Available The last decade has seen a rapid development of experimental techniques that allow data collection from individual cells. These techniques have enabled the discovery and characterization of variability within a population of genetically identical cells. Nonlinear mixed effects (NLME modeling is an established framework for studying variability between individuals in a population, frequently used in pharmacokinetics and pharmacodynamics, but its potential for studies of cell-to-cell variability in molecular cell biology is yet to be exploited. Here we take advantage of this novel application of NLME modeling to study cell-to-cell variability in the dynamic behavior of the yeast transcription repressor Mig1. In particular, we investigate a recently discovered phenomenon where Mig1 during a short and transient period exits the nucleus when cells experience a shift from high to intermediate levels of extracellular glucose. A phenomenological model based on ordinary differential equations describing the transient dynamics of nuclear Mig1 is introduced, and according to the NLME methodology the parameters of this model are in turn modeled by a multivariate probability distribution. Using time-lapse microscopy data from nearly 200 cells, we estimate this parameter distribution according to the approach of maximizing the population likelihood. Based on the estimated distribution, parameter values for individual cells are furthermore characterized and the resulting Mig1 dynamics are compared to the single cell times-series data. The proposed NLME framework is also compared to the intuitive but limited standard two-stage (STS approach. We demonstrate that the latter may overestimate variabilities by up to almost five fold. Finally, Monte Carlo simulations of the inferred population model are used to predict the distribution of key characteristics of the Mig1 transient response. We find that with decreasing levels of post-shift glucose, the transient

  19. Nonlinear mixed effects dose response modeling in high throughput drug screens: application to melanoma cell line analysis.

    Science.gov (United States)

    Ding, Kuan-Fu; Petricoin, Emanuel F; Finlay, Darren; Yin, Hongwei; Hendricks, William P D; Sereduk, Chris; Kiefer, Jeffrey; Sekulic, Aleksandar; LoRusso, Patricia M; Vuori, Kristiina; Trent, Jeffrey M; Schork, Nicholas J

    2018-01-12

    Cancer cell lines are often used in high throughput drug screens (HTS) to explore the relationship between cell line characteristics and responsiveness to different therapies. Many current analysis methods infer relationships by focusing on one aspect of cell line drug-specific dose-response curves (DRCs), the concentration causing 50% inhibition of a phenotypic endpoint (IC 50 ). Such methods may overlook DRC features and do not simultaneously leverage information about drug response patterns across cell lines, potentially increasing false positive and negative rates in drug response associations. We consider the application of two methods, each rooted in nonlinear mixed effects (NLME) models, that test the relationship relationships between estimated cell line DRCs and factors that might mitigate response. Both methods leverage estimation and testing techniques that consider the simultaneous analysis of different cell lines to draw inferences about any one cell line. One of the methods is designed to provide an omnibus test of the differences between cell line DRCs that is not focused on any one aspect of the DRC (such as the IC 50 value). We simulated different settings and compared the different methods on the simulated data. We also compared the proposed methods against traditional IC 50 -based methods using 40 melanoma cell lines whose transcriptomes, proteomes, and, importantly, BRAF and related mutation profiles were available. Ultimately, we find that the NLME-based methods are more robust, powerful and, for the omnibus test, more flexible, than traditional methods. Their application to the melanoma cell lines reveals insights into factors that may be clinically useful.

  20. Kriging with mixed effects models

    Directory of Open Access Journals (Sweden)

    Alessio Pollice

    2007-10-01

    Full Text Available In this paper the effectiveness of the use of mixed effects models for estimation and prediction purposes in spatial statistics for continuous data is reviewed in the classical and Bayesian frameworks. A case study on agricultural data is also provided.

  1. Evolution of association between renal and liver functions while awaiting heart transplant: An application using a bivariate multiphase nonlinear mixed effects model.

    Science.gov (United States)

    Rajeswaran, Jeevanantham; Blackstone, Eugene H; Barnard, John

    2018-07-01

    In many longitudinal follow-up studies, we observe more than one longitudinal outcome. Impaired renal and liver functions are indicators of poor clinical outcomes for patients who are on mechanical circulatory support and awaiting heart transplant. Hence, monitoring organ functions while waiting for heart transplant is an integral part of patient management. Longitudinal measurements of bilirubin can be used as a marker for liver function and glomerular filtration rate for renal function. We derive an approximation to evolution of association between these two organ functions using a bivariate nonlinear mixed effects model for continuous longitudinal measurements, where the two submodels are linked by a common distribution of time-dependent latent variables and a common distribution of measurement errors.

  2. Estimate the time varying brain receptor occupancy in PET imaging experiments using non-linear fixed and mixed effect modeling approach

    International Nuclear Information System (INIS)

    Zamuner, Stefano; Gomeni, Roberto; Bye, Alan

    2002-01-01

    Positron-Emission Tomography (PET) is an imaging technology currently used in drug development as a non-invasive measure of drug distribution and interaction with biochemical target system. The level of receptor occupancy achieved by a compound can be estimated by comparing time-activity measurements in an experiment done using tracer alone with the activity measured when the tracer is given following administration of unlabelled compound. The effective use of this surrogate marker as an enabling tool for drug development requires the definition of a model linking the brain receptor occupancy with the fluctuation of plasma concentrations. However, the predictive performance of such a model is strongly related to the precision on the estimate of receptor occupancy evaluated in PET scans collected at different times following drug treatment. Several methods have been proposed for the analysis and the quantification of the ligand-receptor interactions investigated from PET data. The aim of the present study is to evaluate alternative parameter estimation strategies based on the use of non-linear mixed effect models allowing to account for intra and inter-subject variability on the time-activity and for covariates potentially explaining this variability. A comparison of the different modeling approaches is presented using real data. The results of this comparison indicates that the mixed effect approach with a primary model partitioning the variance in term of Inter-Individual Variability (IIV) and Inter-Occasion Variability (IOV) and a second stage model relating the changes on binding potential to the dose of unlabelled drug is definitely the preferred approach

  3. Quantifying the Variability of Internode Allometry within and between Trees for Pinus tabulaeformis Carr. Using a Multilevel Nonlinear Mixed-Effect Model

    Directory of Open Access Journals (Sweden)

    Jun Diao

    2014-11-01

    Full Text Available Allometric models of internodes are an important component of Functional-Structural Plant Models (FSPMs, which represent the shape of internodes in tree architecture and help our understanding of resource allocation in organisms. Constant allometry is always assumed in these models. In this paper, multilevel nonlinear mixed-effect models were used to characterize the variability of internode allometry, describing the relationship between the last internode length and biomass of Pinus tabulaeformis Carr. trees within the GreenLab framework. We demonstrated that there is significant variability in allometric relationships at the tree and different-order branch levels, and the variability decreases among levels from trees to first-order branches and, subsequently, to second-order branches. The variability was partially explained by the random effects of site characteristics, stand age, density, and topological position of the internode. Tree- and branch-level-specific allometric models are recommended because they produce unbiased and accurate internode length estimates. The model and method developed in this study are useful for understanding and describing the structure and functioning of trees.

  4. Use of non-linear mixed-effects modelling and regression analysis to predict the number of somatic coliphages by plaque enumeration after 3 hours of incubation.

    Science.gov (United States)

    Mendez, Javier; Monleon-Getino, Antonio; Jofre, Juan; Lucena, Francisco

    2017-10-01

    The present study aimed to establish the kinetics of the appearance of coliphage plaques using the double agar layer titration technique to evaluate the feasibility of using traditional coliphage plaque forming unit (PFU) enumeration as a rapid quantification method. Repeated measurements of the appearance of plaques of coliphages titrated according to ISO 10705-2 at different times were analysed using non-linear mixed-effects regression to determine the most suitable model of their appearance kinetics. Although this model is adequate, to simplify its applicability two linear models were developed to predict the numbers of coliphages reliably, using the PFU counts as determined by the ISO after only 3 hours of incubation. One linear model, when the number of plaques detected was between 4 and 26 PFU after 3 hours, had a linear fit of: (1.48 × Counts 3 h + 1.97); and the other, values >26 PFU, had a fit of (1.18 × Counts 3 h + 2.95). If the number of plaques detected was PFU after 3 hours, we recommend incubation for (18 ± 3) hours. The study indicates that the traditional coliphage plating technique has a reasonable potential to provide results in a single working day without the need to invest in additional laboratory equipment.

  5. Mixed-effects regression models in linguistics

    CERN Document Server

    Heylen, Kris; Geeraerts, Dirk

    2018-01-01

    When data consist of grouped observations or clusters, and there is a risk that measurements within the same group are not independent, group-specific random effects can be added to a regression model in order to account for such within-group associations. Regression models that contain such group-specific random effects are called mixed-effects regression models, or simply mixed models. Mixed models are a versatile tool that can handle both balanced and unbalanced datasets and that can also be applied when several layers of grouping are present in the data; these layers can either be nested or crossed.  In linguistics, as in many other fields, the use of mixed models has gained ground rapidly over the last decade. This methodological evolution enables us to build more sophisticated and arguably more realistic models, but, due to its technical complexity, also introduces new challenges. This volume brings together a number of promising new evolutions in the use of mixed models in linguistics, but also addres...

  6. A multivariate nonlinear mixed effects method for analyzing energy partitioning in growing pigs

    DEFF Research Database (Denmark)

    Strathe, Anders Bjerring; Danfær, Allan Christian; Chwalibog, André

    2010-01-01

    to the multivariate nonlinear regression model because the MNLME method accounted for correlated errors associated with PD and LD measurements and could also include the random effect of animal. It is recommended that multivariate models used to quantify energy metabolism in growing pigs should account for animal......Simultaneous equations have become increasingly popular for describing the effects of nutrition on the utilization of ME for protein (PD) and lipid deposition (LD) in animals. The study developed a multivariate nonlinear mixed effects (MNLME) framework and compared it with an alternative method...... for estimating parameters in simultaneous equations that described energy metabolism in growing pigs, and then proposed new PD and LD equations. The general statistical framework was implemented in the NLMIXED procedure in SAS. Alternative PD and LD equations were also developed, which assumed...

  7. A Second-Order Conditionally Linear Mixed Effects Model with Observed and Latent Variable Covariates

    Science.gov (United States)

    Harring, Jeffrey R.; Kohli, Nidhi; Silverman, Rebecca D.; Speece, Deborah L.

    2012-01-01

    A conditionally linear mixed effects model is an appropriate framework for investigating nonlinear change in a continuous latent variable that is repeatedly measured over time. The efficacy of the model is that it allows parameters that enter the specified nonlinear time-response function to be stochastic, whereas those parameters that enter in a…

  8. Semiparametric mixed-effects analysis of PK/PD models using differential equations.

    Science.gov (United States)

    Wang, Yi; Eskridge, Kent M; Zhang, Shunpu

    2008-08-01

    Motivated by the use of semiparametric nonlinear mixed-effects modeling on longitudinal data, we develop a new semiparametric modeling approach to address potential structural model misspecification for population pharmacokinetic/pharmacodynamic (PK/PD) analysis. Specifically, we use a set of ordinary differential equations (ODEs) with form dx/dt = A(t)x + B(t) where B(t) is a nonparametric function that is estimated using penalized splines. The inclusion of a nonparametric function in the ODEs makes identification of structural model misspecification feasible by quantifying the model uncertainty and provides flexibility for accommodating possible structural model deficiencies. The resulting model will be implemented in a nonlinear mixed-effects modeling setup for population analysis. We illustrate the method with an application to cefamandole data and evaluate its performance through simulations.

  9. Functional Mixed Effects Model for Small Area Estimation.

    Science.gov (United States)

    Maiti, Tapabrata; Sinha, Samiran; Zhong, Ping-Shou

    2016-09-01

    Functional data analysis has become an important area of research due to its ability of handling high dimensional and complex data structures. However, the development is limited in the context of linear mixed effect models, and in particular, for small area estimation. The linear mixed effect models are the backbone of small area estimation. In this article, we consider area level data, and fit a varying coefficient linear mixed effect model where the varying coefficients are semi-parametrically modeled via B-splines. We propose a method of estimating the fixed effect parameters and consider prediction of random effects that can be implemented using a standard software. For measuring prediction uncertainties, we derive an analytical expression for the mean squared errors, and propose a method of estimating the mean squared errors. The procedure is illustrated via a real data example, and operating characteristics of the method are judged using finite sample simulation studies.

  10. Longitudinal mixed-effects models for latent cognitive function

    NARCIS (Netherlands)

    van den Hout, Ardo; Fox, Gerardus J.A.; Muniz-Terrera, Graciela

    2015-01-01

    A mixed-effects regression model with a bent-cable change-point predictor is formulated to describe potential decline of cognitive function over time in the older population. For the individual trajectories, cognitive function is considered to be a latent variable measured through an item response

  11. Translational mixed-effects PKPD modelling of recombinant human growth hormone - from hypophysectomized rat to patients

    DEFF Research Database (Denmark)

    Thorsted, A; Thygesen, P; Agersø, H

    2016-01-01

    BACKGROUND AND PURPOSE: We aimed to develop a mechanistic mixed-effects pharmacokinetic (PK)-pharmacodynamic (PD) (PKPD) model for recombinant human growth hormone (rhGH) in hypophysectomized rats and to predict the human PKPD relationship. EXPERIMENTAL APPROACH: A non-linear mixed-effects model...... was developed from experimental PKPD studies of rhGH and effects of long-term treatment as measured by insulin-like growth factor 1 (IGF-1) and bodyweight gain in rats. Modelled parameter values were scaled to human values using the allometric approach with fixed exponents for PKs and unscaled for PDs...... s.c. administration was over predicted. After correction of the human s.c. absorption model, the induction model for IGF-1 well described the human PKPD data. CONCLUSIONS: A translational mechanistic PKPD model for rhGH was successfully developed from experimental rat data. The model links...

  12. A Linear Mixed-Effects Model of Wireless Spectrum Occupancy

    Directory of Open Access Journals (Sweden)

    Pagadarai Srikanth

    2010-01-01

    Full Text Available We provide regression analysis-based statistical models to explain the usage of wireless spectrum across four mid-size US cities in four frequency bands. Specifically, the variations in spectrum occupancy across space, time, and frequency are investigated and compared between different sites within the city as well as with other cities. By applying the mixed-effects models, several conclusions are drawn that give the occupancy percentage and the ON time duration of the licensed signal transmission as a function of several predictor variables.

  13. Modelling subject-specific childhood growth using linear mixed-effect models with cubic regression splines.

    Science.gov (United States)

    Grajeda, Laura M; Ivanescu, Andrada; Saito, Mayuko; Crainiceanu, Ciprian; Jaganath, Devan; Gilman, Robert H; Crabtree, Jean E; Kelleher, Dermott; Cabrera, Lilia; Cama, Vitaliano; Checkley, William

    2016-01-01

    Childhood growth is a cornerstone of pediatric research. Statistical models need to consider individual trajectories to adequately describe growth outcomes. Specifically, well-defined longitudinal models are essential to characterize both population and subject-specific growth. Linear mixed-effect models with cubic regression splines can account for the nonlinearity of growth curves and provide reasonable estimators of population and subject-specific growth, velocity and acceleration. We provide a stepwise approach that builds from simple to complex models, and account for the intrinsic complexity of the data. We start with standard cubic splines regression models and build up to a model that includes subject-specific random intercepts and slopes and residual autocorrelation. We then compared cubic regression splines vis-à-vis linear piecewise splines, and with varying number of knots and positions. Statistical code is provided to ensure reproducibility and improve dissemination of methods. Models are applied to longitudinal height measurements in a cohort of 215 Peruvian children followed from birth until their fourth year of life. Unexplained variability, as measured by the variance of the regression model, was reduced from 7.34 when using ordinary least squares to 0.81 (p linear mixed-effect models with random slopes and a first order continuous autoregressive error term. There was substantial heterogeneity in both the intercept (p modeled with a first order continuous autoregressive error term as evidenced by the variogram of the residuals and by a lack of association among residuals. The final model provides a parametric linear regression equation for both estimation and prediction of population- and individual-level growth in height. We show that cubic regression splines are superior to linear regression splines for the case of a small number of knots in both estimation and prediction with the full linear mixed effect model (AIC 19,352 vs. 19

  14. Non-linear mixed-effects modeling for photosynhetic response of Rosa hybrida L. under elevated CO2 in greenhouses - short communication

    DEFF Research Database (Denmark)

    Ozturk, I.; Ottosen, C.O.; Ritz, Christian

    2011-01-01

    conditions. Leaf gas exchanges were measured at 11 light intensities from 0 to 1,400 µmol/m2s, at 800 ppm CO2, 25°C, and 65 ± 5% relative humidity. In order to describe the data corresponding to diff erent measurement dates, the non-linear mixed-eff ects regression analysis was used. Th e model successfully...... effi ciency. Th e results suggested acclimation response, as carbon assimilation rates and stomatal conductance at each measurement date were higher for Escimo than Mercedes. Diff erences in photosynthesis rates were attributed to the adaptive capacity of the cultivars to light conditions at a specifi......Photosynthetic response to light was measured on the leaves of two cultivars of Rosa hybrida L. (Escimo and Mercedes) in the greenhouse to obtain light-response curves and their parameters. Th e aim was to use a model to simulate leaf photosynthetic carbon gain with respect to environmental...

  15. Latent Fundamentals Arbitrage with a Mixed Effects Factor Model

    Directory of Open Access Journals (Sweden)

    Andrei Salem Gonçalves

    2012-09-01

    Full Text Available We propose a single-factor mixed effects panel data model to create an arbitrage portfolio that identifies differences in firm-level latent fundamentals. Furthermore, we show that even though the characteristics that affect returns are unknown variables, it is possible to identify the strength of the combination of these latent fundamentals for each stock by following a simple approach using historical data. As a result, a trading strategy that bought the stocks with the best fundamentals (strong fundamentals portfolio and sold the stocks with the worst ones (weak fundamentals portfolio realized significant risk-adjusted returns in the U.S. market for the period between July 1986 and June 2008. To ensure robustness, we performed sub period and seasonal analyses and adjusted for trading costs and we found further empirical evidence that using a simple investment rule, that identified these latent fundamentals from the structure of past returns, can lead to profit.

  16. Evaluating significance in linear mixed-effects models in R.

    Science.gov (United States)

    Luke, Steven G

    2017-08-01

    Mixed-effects models are being used ever more frequently in the analysis of experimental data. However, in the lme4 package in R the standards for evaluating significance of fixed effects in these models (i.e., obtaining p-values) are somewhat vague. There are good reasons for this, but as researchers who are using these models are required in many cases to report p-values, some method for evaluating the significance of the model output is needed. This paper reports the results of simulations showing that the two most common methods for evaluating significance, using likelihood ratio tests and applying the z distribution to the Wald t values from the model output (t-as-z), are somewhat anti-conservative, especially for smaller sample sizes. Other methods for evaluating significance, including parametric bootstrapping and the Kenward-Roger and Satterthwaite approximations for degrees of freedom, were also evaluated. The results of these simulations suggest that Type 1 error rates are closest to .05 when models are fitted using REML and p-values are derived using the Kenward-Roger or Satterthwaite approximations, as these approximations both produced acceptable Type 1 error rates even for smaller samples.

  17. Influence of the Size of Cohorts in Adaptive Design for Nonlinear Mixed Effects Models: An Evaluation by Simulation for a Pharmacokinetic and Pharmacodynamic Model for a Biomarker in Oncology

    Science.gov (United States)

    Lestini, Giulia; Dumont, Cyrielle; Mentré, France

    2015-01-01

    Purpose In this study we aimed to evaluate adaptive designs (ADs) by clinical trial simulation for a pharmacokinetic-pharmacodynamic model in oncology and to compare them with one-stage designs, i.e. when no adaptation is performed, using wrong prior parameters. Methods We evaluated two one-stage designs, ξ0 and ξ*, optimised for prior and true population parameters, Ψ0 and Ψ*, and several ADs (two-, three- and five-stage). All designs had 50 patients. For ADs, the first cohort design was ξ0. The next cohort design was optimised using prior information updated from the previous cohort. Optimal design was based on the determinant of the Fisher information matrix using PFIM. Design evaluation was performed by clinical trial simulations using data simulated from Ψ*. Results Estimation results of two-stage ADs and ξ* were close and much better than those obtained with ξ0. The balanced two-stage AD performed better than two-stage ADs with different cohort sizes. Three-and five-stage ADs were better than two-stage with small first cohort, but not better than the balanced two-stage design. Conclusions Two-stage ADs are useful when prior parameters are unreliable. In case of small first cohort, more adaptations are needed but these designs are complex to implement. PMID:26123680

  18. Linear mixed-effects modeling approach to FMRI group analysis.

    Science.gov (United States)

    Chen, Gang; Saad, Ziad S; Britton, Jennifer C; Pine, Daniel S; Cox, Robert W

    2013-06-01

    Conventional group analysis is usually performed with Student-type t-test, regression, or standard AN(C)OVA in which the variance-covariance matrix is presumed to have a simple structure. Some correction approaches are adopted when assumptions about the covariance structure is violated. However, as experiments are designed with different degrees of sophistication, these traditional methods can become cumbersome, or even be unable to handle the situation at hand. For example, most current FMRI software packages have difficulty analyzing the following scenarios at group level: (1) taking within-subject variability into account when there are effect estimates from multiple runs or sessions; (2) continuous explanatory variables (covariates) modeling in the presence of a within-subject (repeated measures) factor, multiple subject-grouping (between-subjects) factors, or the mixture of both; (3) subject-specific adjustments in covariate modeling; (4) group analysis with estimation of hemodynamic response (HDR) function by multiple basis functions; (5) various cases of missing data in longitudinal studies; and (6) group studies involving family members or twins. Here we present a linear mixed-effects modeling (LME) methodology that extends the conventional group analysis approach to analyze many complicated cases, including the six prototypes delineated above, whose analyses would be otherwise either difficult or unfeasible under traditional frameworks such as AN(C)OVA and general linear model (GLM). In addition, the strength of the LME framework lies in its flexibility to model and estimate the variance-covariance structures for both random effects and residuals. The intraclass correlation (ICC) values can be easily obtained with an LME model with crossed random effects, even at the presence of confounding fixed effects. The simulations of one prototypical scenario indicate that the LME modeling keeps a balance between the control for false positives and the sensitivity

  19. Influence assessment in censored mixed-effects models using the multivariate Student’s-t distribution

    Science.gov (United States)

    Matos, Larissa A.; Bandyopadhyay, Dipankar; Castro, Luis M.; Lachos, Victor H.

    2015-01-01

    In biomedical studies on HIV RNA dynamics, viral loads generate repeated measures that are often subjected to upper and lower detection limits, and hence these responses are either left- or right-censored. Linear and non-linear mixed-effects censored (LMEC/NLMEC) models are routinely used to analyse these longitudinal data, with normality assumptions for the random effects and residual errors. However, the derived inference may not be robust when these underlying normality assumptions are questionable, especially the presence of outliers and thick-tails. Motivated by this, Matos et al. (2013b) recently proposed an exact EM-type algorithm for LMEC/NLMEC models using a multivariate Student’s-t distribution, with closed-form expressions at the E-step. In this paper, we develop influence diagnostics for LMEC/NLMEC models using the multivariate Student’s-t density, based on the conditional expectation of the complete data log-likelihood. This partially eliminates the complexity associated with the approach of Cook (1977, 1986) for censored mixed-effects models. The new methodology is illustrated via an application to a longitudinal HIV dataset. In addition, a simulation study explores the accuracy of the proposed measures in detecting possible influential observations for heavy-tailed censored data under different perturbation and censoring schemes. PMID:26190871

  20. Extending existing structural identifiability analysis methods to mixed-effects models.

    Science.gov (United States)

    Janzén, David L I; Jirstrand, Mats; Chappell, Michael J; Evans, Neil D

    2018-01-01

    The concept of structural identifiability for state-space models is expanded to cover mixed-effects state-space models. Two methods applicable for the analytical study of the structural identifiability of mixed-effects models are presented. The two methods are based on previously established techniques for non-mixed-effects models; namely the Taylor series expansion and the input-output form approach. By generating an exhaustive summary, and by assuming an infinite number of subjects, functions of random variables can be derived which in turn determine the distribution of the system's observation function(s). By considering the uniqueness of the analytical statistical moments of the derived functions of the random variables, the structural identifiability of the corresponding mixed-effects model can be determined. The two methods are applied to a set of examples of mixed-effects models to illustrate how they work in practice. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Mixed Effects Modeling Using Stochastic Differential Equations: Illustrated by Pharmacokinetic Data of Nicotinic Acid in Obese Zucker Rats.

    Science.gov (United States)

    Leander, Jacob; Almquist, Joachim; Ahlström, Christine; Gabrielsson, Johan; Jirstrand, Mats

    2015-05-01

    Inclusion of stochastic differential equations in mixed effects models provides means to quantify and distinguish three sources of variability in data. In addition to the two commonly encountered sources, measurement error and interindividual variability, we also consider uncertainty in the dynamical model itself. To this end, we extend the ordinary differential equation setting used in nonlinear mixed effects models to include stochastic differential equations. The approximate population likelihood is derived using the first-order conditional estimation with interaction method and extended Kalman filtering. To illustrate the application of the stochastic differential mixed effects model, two pharmacokinetic models are considered. First, we use a stochastic one-compartmental model with first-order input and nonlinear elimination to generate synthetic data in a simulated study. We show that by using the proposed method, the three sources of variability can be successfully separated. If the stochastic part is neglected, the parameter estimates become biased, and the measurement error variance is significantly overestimated. Second, we consider an extension to a stochastic pharmacokinetic model in a preclinical study of nicotinic acid kinetics in obese Zucker rats. The parameter estimates are compared between a deterministic and a stochastic NiAc disposition model, respectively. Discrepancies between model predictions and observations, previously described as measurement noise only, are now separated into a comparatively lower level of measurement noise and a significant uncertainty in model dynamics. These examples demonstrate that stochastic differential mixed effects models are useful tools for identifying incomplete or inaccurate model dynamics and for reducing potential bias in parameter estimates due to such model deficiencies.

  2. Three novel approaches to structural identifiability analysis in mixed-effects models.

    Science.gov (United States)

    Janzén, David L I; Jirstrand, Mats; Chappell, Michael J; Evans, Neil D

    2016-05-06

    Structural identifiability is a concept that considers whether the structure of a model together with a set of input-output relations uniquely determines the model parameters. In the mathematical modelling of biological systems, structural identifiability is an important concept since biological interpretations are typically made from the parameter estimates. For a system defined by ordinary differential equations, several methods have been developed to analyse whether the model is structurally identifiable or otherwise. Another well-used modelling framework, which is particularly useful when the experimental data are sparsely sampled and the population variance is of interest, is mixed-effects modelling. However, established identifiability analysis techniques for ordinary differential equations are not directly applicable to such models. In this paper, we present and apply three different methods that can be used to study structural identifiability in mixed-effects models. The first method, called the repeated measurement approach, is based on applying a set of previously established statistical theorems. The second method, called the augmented system approach, is based on augmenting the mixed-effects model to an extended state-space form. The third method, called the Laplace transform mixed-effects extension, is based on considering the moment invariants of the systems transfer function as functions of random variables. To illustrate, compare and contrast the application of the three methods, they are applied to a set of mixed-effects models. Three structural identifiability analysis methods applicable to mixed-effects models have been presented in this paper. As method development of structural identifiability techniques for mixed-effects models has been given very little attention, despite mixed-effects models being widely used, the methods presented in this paper provides a way of handling structural identifiability in mixed-effects models previously not

  3. Application of Hierarchical Linear Models/Linear Mixed-Effects Models in School Effectiveness Research

    Science.gov (United States)

    Ker, H. W.

    2014-01-01

    Multilevel data are very common in educational research. Hierarchical linear models/linear mixed-effects models (HLMs/LMEs) are often utilized to analyze multilevel data nowadays. This paper discusses the problems of utilizing ordinary regressions for modeling multilevel educational data, compare the data analytic results from three regression…

  4. Non-linear mixed-effects modeling for photosynthetic response of Rosa hybrida L. under elevated CO2 in greenhouses - Short communication

    DEFF Research Database (Denmark)

    Öztürk, I.; Ottosen, C.O.; Ritz, C.

    2011-01-01

    Photosynthetic response to light was measured on the leaves of two cultivars of Rosa hybrida L. (Escimo and Mercedes) in the greenhouse to obtain light-response curves and their parameters. Th e aim was to use a model to simulate leaf photosynthetic carbon gain with respect to environmental condi...

  5. Generalized Nonlinear Yule Models

    OpenAIRE

    Lansky, Petr; Polito, Federico; Sacerdote, Laura

    2016-01-01

    With the aim of considering models with persistent memory we propose a fractional nonlinear modification of the classical Yule model often studied in the context of macrovolution. Here the model is analyzed and interpreted in the framework of the development of networks such as the World Wide Web. Nonlinearity is introduced by replacing the linear birth process governing the growth of the in-links of each specific webpage with a fractional nonlinear birth process with completely general birth...

  6. Valid statistical approaches for analyzing sholl data: Mixed effects versus simple linear models.

    Science.gov (United States)

    Wilson, Machelle D; Sethi, Sunjay; Lein, Pamela J; Keil, Kimberly P

    2017-03-01

    The Sholl technique is widely used to quantify dendritic morphology. Data from such studies, which typically sample multiple neurons per animal, are often analyzed using simple linear models. However, simple linear models fail to account for intra-class correlation that occurs with clustered data, which can lead to faulty inferences. Mixed effects models account for intra-class correlation that occurs with clustered data; thus, these models more accurately estimate the standard deviation of the parameter estimate, which produces more accurate p-values. While mixed models are not new, their use in neuroscience has lagged behind their use in other disciplines. A review of the published literature illustrates common mistakes in analyses of Sholl data. Analysis of Sholl data collected from Golgi-stained pyramidal neurons in the hippocampus of male and female mice using both simple linear and mixed effects models demonstrates that the p-values and standard deviations obtained using the simple linear models are biased downwards and lead to erroneous rejection of the null hypothesis in some analyses. The mixed effects approach more accurately models the true variability in the data set, which leads to correct inference. Mixed effects models avoid faulty inference in Sholl analysis of data sampled from multiple neurons per animal by accounting for intra-class correlation. Given the widespread practice in neuroscience of obtaining multiple measurements per subject, there is a critical need to apply mixed effects models more widely. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Modelling ventricular fibrillation coarseness during cardiopulmonary resuscitation by mixed effects stochastic differential equations.

    Science.gov (United States)

    Gundersen, Kenneth; Kvaløy, Jan Terje; Eftestøl, Trygve; Kramer-Johansen, Jo

    2015-10-15

    For patients undergoing cardiopulmonary resuscitation (CPR) and being in a shockable rhythm, the coarseness of the electrocardiogram (ECG) signal is an indicator of the state of the patient. In the current work, we show how mixed effects stochastic differential equations (SDE) models, commonly used in pharmacokinetic and pharmacodynamic modelling, can be used to model the relationship between CPR quality measurements and ECG coarseness. This is a novel application of mixed effects SDE models to a setting quite different from previous applications of such models and where using such models nicely solves many of the challenges involved in analysing the available data. Copyright © 2015 John Wiley & Sons, Ltd.

  8. Multivariate longitudinal data analysis with mixed effects hidden Markov models.

    Science.gov (United States)

    Raffa, Jesse D; Dubin, Joel A

    2015-09-01

    Multiple longitudinal responses are often collected as a means to capture relevant features of the true outcome of interest, which is often hidden and not directly measurable. We outline an approach which models these multivariate longitudinal responses as generated from a hidden disease process. We propose a class of models which uses a hidden Markov model with separate but correlated random effects between multiple longitudinal responses. This approach was motivated by a smoking cessation clinical trial, where a bivariate longitudinal response involving both a continuous and a binomial response was collected for each participant to monitor smoking behavior. A Bayesian method using Markov chain Monte Carlo is used. Comparison of separate univariate response models to the bivariate response models was undertaken. Our methods are demonstrated on the smoking cessation clinical trial dataset, and properties of our approach are examined through extensive simulation studies. © 2015, The International Biometric Society.

  9. Estimation and Inference for Very Large Linear Mixed Effects Models

    OpenAIRE

    Gao, K.; Owen, A. B.

    2016-01-01

    Linear mixed models with large imbalanced crossed random effects structures pose severe computational problems for maximum likelihood estimation and for Bayesian analysis. The costs can grow as fast as $N^{3/2}$ when there are N observations. Such problems arise in any setting where the underlying factors satisfy a many to many relationship (instead of a nested one) and in electronic commerce applications, the N can be quite large. Methods that do not account for the correlation structure can...

  10. lmerTest Package: Tests in Linear Mixed Effects Models

    DEFF Research Database (Denmark)

    Kuznetsova, Alexandra; Brockhoff, Per B.; Christensen, Rune Haubo Bojesen

    2017-01-01

    One of the frequent questions by users of the mixed model function lmer of the lme4 package has been: How can I get p values for the F and t tests for objects returned by lmer? The lmerTest package extends the 'lmerMod' class of the lme4 package, by overloading the anova and summary functions...... by providing p values for tests for fixed effects. We have implemented the Satterthwaite's method for approximating degrees of freedom for the t and F tests. We have also implemented the construction of Type I - III ANOVA tables. Furthermore, one may also obtain the summary as well as the anova table using...

  11. The use of copulas to practical estimation of multivariate stochastic differential equation mixed effects models

    International Nuclear Information System (INIS)

    Rupšys, P.

    2015-01-01

    A system of stochastic differential equations (SDE) with mixed-effects parameters and multivariate normal copula density function were used to develop tree height model for Scots pine trees in Lithuania. A two-step maximum likelihood parameter estimation method is used and computational guidelines are given. After fitting the conditional probability density functions to outside bark diameter at breast height, and total tree height, a bivariate normal copula distribution model was constructed. Predictions from the mixed-effects parameters SDE tree height model calculated during this research were compared to the regression tree height equations. The results are implemented in the symbolic computational language MAPLE

  12. The use of copulas to practical estimation of multivariate stochastic differential equation mixed effects models

    Energy Technology Data Exchange (ETDEWEB)

    Rupšys, P. [Aleksandras Stulginskis University, Studenų g. 11, Akademija, Kaunas district, LT – 53361 Lithuania (Lithuania)

    2015-10-28

    A system of stochastic differential equations (SDE) with mixed-effects parameters and multivariate normal copula density function were used to develop tree height model for Scots pine trees in Lithuania. A two-step maximum likelihood parameter estimation method is used and computational guidelines are given. After fitting the conditional probability density functions to outside bark diameter at breast height, and total tree height, a bivariate normal copula distribution model was constructed. Predictions from the mixed-effects parameters SDE tree height model calculated during this research were compared to the regression tree height equations. The results are implemented in the symbolic computational language MAPLE.

  13. Population stochastic modelling (PSM)--an R package for mixed-effects models based on stochastic differential equations.

    Science.gov (United States)

    Klim, Søren; Mortensen, Stig Bousgaard; Kristensen, Niels Rode; Overgaard, Rune Viig; Madsen, Henrik

    2009-06-01

    The extension from ordinary to stochastic differential equations (SDEs) in pharmacokinetic and pharmacodynamic (PK/PD) modelling is an emerging field and has been motivated in a number of articles [N.R. Kristensen, H. Madsen, S.H. Ingwersen, Using stochastic differential equations for PK/PD model development, J. Pharmacokinet. Pharmacodyn. 32 (February(1)) (2005) 109-141; C.W. Tornøe, R.V. Overgaard, H. Agersø, H.A. Nielsen, H. Madsen, E.N. Jonsson, Stochastic differential equations in NONMEM: implementation, application, and comparison with ordinary differential equations, Pharm. Res. 22 (August(8)) (2005) 1247-1258; R.V. Overgaard, N. Jonsson, C.W. Tornøe, H. Madsen, Non-linear mixed-effects models with stochastic differential equations: implementation of an estimation algorithm, J. Pharmacokinet. Pharmacodyn. 32 (February(1)) (2005) 85-107; U. Picchini, S. Ditlevsen, A. De Gaetano, Maximum likelihood estimation of a time-inhomogeneous stochastic differential model of glucose dynamics, Math. Med. Biol. 25 (June(2)) (2008) 141-155]. PK/PD models are traditionally based ordinary differential equations (ODEs) with an observation link that incorporates noise. This state-space formulation only allows for observation noise and not for system noise. Extending to SDEs allows for a Wiener noise component in the system equations. This additional noise component enables handling of autocorrelated residuals originating from natural variation or systematic model error. Autocorrelated residuals are often partly ignored in PK/PD modelling although violating the hypothesis for many standard statistical tests. This article presents a package for the statistical program R that is able to handle SDEs in a mixed-effects setting. The estimation method implemented is the FOCE(1) approximation to the population likelihood which is generated from the individual likelihoods that are approximated using the Extended Kalman Filter's one-step predictions.

  14. Examples of mixed-effects modeling with crossed random effects and with binomial data

    NARCIS (Netherlands)

    Quené, H.; van den Bergh, H.

    2008-01-01

    Psycholinguistic data are often analyzed with repeated-measures analyses of variance (ANOVA), but this paper argues that mixed-effects (multilevel) models provide a better alternative method. First, models are discussed in which the two random factors of participants and items are crossed, and not

  15. Mixed-effects height–diameter models for ten conifers in the inland ...

    African Journals Online (AJOL)

    To demonstrate the utility of mixed-effects height–diameter models when conducting forest inventories, mixedeffects height–diameter models are presented for several commercially and ecologically important conifers in the inland Northwest of the USA. After obtaining height–diameter measurements from a plot/stand of ...

  16. Extending the linear model with R generalized linear, mixed effects and nonparametric regression models

    CERN Document Server

    Faraway, Julian J

    2005-01-01

    Linear models are central to the practice of statistics and form the foundation of a vast range of statistical methodologies. Julian J. Faraway''s critically acclaimed Linear Models with R examined regression and analysis of variance, demonstrated the different methods available, and showed in which situations each one applies. Following in those footsteps, Extending the Linear Model with R surveys the techniques that grow from the regression model, presenting three extensions to that framework: generalized linear models (GLMs), mixed effect models, and nonparametric regression models. The author''s treatment is thoroughly modern and covers topics that include GLM diagnostics, generalized linear mixed models, trees, and even the use of neural networks in statistics. To demonstrate the interplay of theory and practice, throughout the book the author weaves the use of the R software environment to analyze the data of real examples, providing all of the R commands necessary to reproduce the analyses. All of the ...

  17. QCD mixing effects in a gauge invariant quark model for photo- and electroproduction of baryon resonances

    International Nuclear Information System (INIS)

    Zhenping Li; Close, F.E.

    1990-03-01

    The photo and electroproduction of baryon resonances has been calculated using the Constituent Quark Model with chromodynamics consistent with O(υ 2 /c 2 ) for the quarks. We find that the successes of the nonrelativistic quark model are preserved, some problems are removed and that QCD mixing effects may become important with increasing q 2 in electroproduction. For the first time both spectroscopy and transitions receive a unified treatment with a single set of parameters. (author)

  18. Stochastic Mixed-Effects Parameters Bertalanffy Process, with Applications to Tree Crown Width Modeling

    Directory of Open Access Journals (Sweden)

    Petras Rupšys

    2015-01-01

    Full Text Available A stochastic modeling approach based on the Bertalanffy law gained interest due to its ability to produce more accurate results than the deterministic approaches. We examine tree crown width dynamic with the Bertalanffy type stochastic differential equation (SDE and mixed-effects parameters. In this study, we demonstrate how this simple model can be used to calculate predictions of crown width. We propose a parameter estimation method and computational guidelines. The primary goal of the study was to estimate the parameters by considering discrete sampling of the diameter at breast height and crown width and by using maximum likelihood procedure. Performance statistics for the crown width equation include statistical indexes and analysis of residuals. We use data provided by the Lithuanian National Forest Inventory from Scots pine trees to illustrate issues of our modeling technique. Comparison of the predicted crown width values of mixed-effects parameters model with those obtained using fixed-effects parameters model demonstrates the predictive power of the stochastic differential equations model with mixed-effects parameters. All results were implemented in a symbolic algebra system MAPLE.

  19. Skew-t partially linear mixed-effects models for AIDS clinical studies.

    Science.gov (United States)

    Lu, Tao

    2016-01-01

    We propose partially linear mixed-effects models with asymmetry and missingness to investigate the relationship between two biomarkers in clinical studies. The proposed models take into account irregular time effects commonly observed in clinical studies under a semiparametric model framework. In addition, commonly assumed symmetric distributions for model errors are substituted by asymmetric distribution to account for skewness. Further, informative missing data mechanism is accounted for. A Bayesian approach is developed to perform parameter estimation simultaneously. The proposed model and method are applied to an AIDS dataset and comparisons with alternative models are performed.

  20. Detecting treatment-subgroup interactions in clustered data with generalized linear mixed-effects model trees.

    Science.gov (United States)

    Fokkema, M; Smits, N; Zeileis, A; Hothorn, T; Kelderman, H

    2017-10-25

    Identification of subgroups of patients for whom treatment A is more effective than treatment B, and vice versa, is of key importance to the development of personalized medicine. Tree-based algorithms are helpful tools for the detection of such interactions, but none of the available algorithms allow for taking into account clustered or nested dataset structures, which are particularly common in psychological research. Therefore, we propose the generalized linear mixed-effects model tree (GLMM tree) algorithm, which allows for the detection of treatment-subgroup interactions, while accounting for the clustered structure of a dataset. The algorithm uses model-based recursive partitioning to detect treatment-subgroup interactions, and a GLMM to estimate the random-effects parameters. In a simulation study, GLMM trees show higher accuracy in recovering treatment-subgroup interactions, higher predictive accuracy, and lower type II error rates than linear-model-based recursive partitioning and mixed-effects regression trees. Also, GLMM trees show somewhat higher predictive accuracy than linear mixed-effects models with pre-specified interaction effects, on average. We illustrate the application of GLMM trees on an individual patient-level data meta-analysis on treatments for depression. We conclude that GLMM trees are a promising exploratory tool for the detection of treatment-subgroup interactions in clustered datasets.

  1. A brief introduction to regression designs and mixed-effects modelling by a recent convert

    OpenAIRE

    Balling, Laura Winther

    2008-01-01

    This article discusses the advantages of multiple regression designs over the factorial designs traditionally used in many psycholinguistic experiments. It is shown that regression designs are typically more informative, statistically more powerful and better suited to the analysis of naturalistic tasks. The advantages of including both fixed and random effects are demonstrated with reference to linear mixed-effects models, and problems of collinearity, variable distribution and variable sele...

  2. Linear mixed-effects models for central statistical monitoring of multicenter clinical trials

    OpenAIRE

    Desmet, L.; Venet, D.; Doffagne, E.; Timmermans, C.; BURZYKOWSKI, Tomasz; LEGRAND, Catherine; BUYSE, Marc

    2014-01-01

    Multicenter studies are widely used to meet accrual targets in clinical trials. Clinical data monitoring is required to ensure the quality and validity of the data gathered across centers. One approach to this end is central statistical monitoring, which aims at detecting atypical patterns in the data by means of statistical methods. In this context, we consider the simple case of a continuous variable, and we propose a detection procedure based on a linear mixed-effects model to detect locat...

  3. Species Distribution Modeling: Comparison of Fixed and Mixed Effects Models Using INLA

    Directory of Open Access Journals (Sweden)

    Lara Dutra Silva

    2017-12-01

    Full Text Available Invasive alien species are among the most important, least controlled, and least reversible of human impacts on the world’s ecosystems, with negative consequences affecting biodiversity and socioeconomic systems. Species distribution models have become a fundamental tool in assessing the potential spread of invasive species in face of their native counterparts. In this study we compared two different modeling techniques: (i fixed effects models accounting for the effect of ecogeographical variables (EGVs; and (ii mixed effects models including also a Gaussian random field (GRF to model spatial correlation (Matérn covariance function. To estimate the potential distribution of Pittosporum undulatum and Morella faya (respectively, invasive and native trees, we used geo-referenced data of their distribution in Pico and São Miguel islands (Azores and topographic, climatic and land use EGVs. Fixed effects models run with maximum likelihood or the INLA (Integrated Nested Laplace Approximation approach provided very similar results, even when reducing the size of the presences data set. The addition of the GRF increased model adjustment (lower Deviance Information Criterion, particularly for the less abundant tree, M. faya. However, the random field parameters were clearly affected by sample size and species distribution pattern. A high degree of spatial autocorrelation was found and should be taken into account when modeling species distribution.

  4. A brief introduction to mixed effects modelling and multi-model inference in ecology.

    Science.gov (United States)

    Harrison, Xavier A; Donaldson, Lynda; Correa-Cano, Maria Eugenia; Evans, Julian; Fisher, David N; Goodwin, Cecily E D; Robinson, Beth S; Hodgson, David J; Inger, Richard

    2018-01-01

    The use of linear mixed effects models (LMMs) is increasingly common in the analysis of biological data. Whilst LMMs offer a flexible approach to modelling a broad range of data types, ecological data are often complex and require complex model structures, and the fitting and interpretation of such models is not always straightforward. The ability to achieve robust biological inference requires that practitioners know how and when to apply these tools. Here, we provide a general overview of current methods for the application of LMMs to biological data, and highlight the typical pitfalls that can be encountered in the statistical modelling process. We tackle several issues regarding methods of model selection, with particular reference to the use of information theory and multi-model inference in ecology. We offer practical solutions and direct the reader to key references that provide further technical detail for those seeking a deeper understanding. This overview should serve as a widely accessible code of best practice for applying LMMs to complex biological problems and model structures, and in doing so improve the robustness of conclusions drawn from studies investigating ecological and evolutionary questions.

  5. A mixed-effects model approach for the statistical analysis of vocal fold viscoelastic shear properties.

    Science.gov (United States)

    Xu, Chet C; Chan, Roger W; Sun, Han; Zhan, Xiaowei

    2017-11-01

    A mixed-effects model approach was introduced in this study for the statistical analysis of rheological data of vocal fold tissues, in order to account for the data correlation caused by multiple measurements of each tissue sample across the test frequency range. Such data correlation had often been overlooked in previous studies in the past decades. The viscoelastic shear properties of the vocal fold lamina propria of two commonly used laryngeal research animal species (i.e. rabbit, porcine) were measured by a linear, controlled-strain simple-shear rheometer. Along with published canine and human rheological data, the vocal fold viscoelastic shear moduli of these animal species were compared to those of human over a frequency range of 1-250Hz using the mixed-effects models. Our results indicated that tissues of the rabbit, canine and porcine vocal fold lamina propria were significantly stiffer and more viscous than those of human. Mixed-effects models were shown to be able to more accurately analyze rheological data generated from repeated measurements. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Generalized Nonlinear Yule Models

    Science.gov (United States)

    Lansky, Petr; Polito, Federico; Sacerdote, Laura

    2016-11-01

    With the aim of considering models related to random graphs growth exhibiting persistent memory, we propose a fractional nonlinear modification of the classical Yule model often studied in the context of macroevolution. Here the model is analyzed and interpreted in the framework of the development of networks such as the World Wide Web. Nonlinearity is introduced by replacing the linear birth process governing the growth of the in-links of each specific webpage with a fractional nonlinear birth process with completely general birth rates. Among the main results we derive the explicit distribution of the number of in-links of a webpage chosen uniformly at random recognizing the contribution to the asymptotics and the finite time correction. The mean value of the latter distribution is also calculated explicitly in the most general case. Furthermore, in order to show the usefulness of our results, we particularize them in the case of specific birth rates giving rise to a saturating behaviour, a property that is often observed in nature. The further specialization to the non-fractional case allows us to extend the Yule model accounting for a nonlinear growth.

  7. Partially linear mixed-effects joint models for skewed and missing longitudinal competing risks outcomes.

    Science.gov (United States)

    Lu, Tao; Lu, Minggen; Wang, Min; Zhang, Jun; Dong, Guang-Hui; Xu, Yong

    2017-12-18

    Longitudinal competing risks data frequently arise in clinical studies. Skewness and missingness are commonly observed for these data in practice. However, most joint models do not account for these data features. In this article, we propose partially linear mixed-effects joint models to analyze skew longitudinal competing risks data with missingness. In particular, to account for skewness, we replace the commonly assumed symmetric distributions by asymmetric distribution for model errors. To deal with missingness, we employ an informative missing data model. The joint models that couple the partially linear mixed-effects model for the longitudinal process, the cause-specific proportional hazard model for competing risks process and missing data process are developed. To estimate the parameters in the joint models, we propose a fully Bayesian approach based on the joint likelihood. To illustrate the proposed model and method, we implement them to an AIDS clinical study. Some interesting findings are reported. We also conduct simulation studies to validate the proposed method.

  8. Interpretable inference on the mixed effect model with the Box-Cox transformation.

    Science.gov (United States)

    Maruo, K; Yamaguchi, Y; Noma, H; Gosho, M

    2017-07-10

    We derived results for inference on parameters of the marginal model of the mixed effect model with the Box-Cox transformation based on the asymptotic theory approach. We also provided a robust variance estimator of the maximum likelihood estimator of the parameters of this model in consideration of the model misspecifications. Using these results, we developed an inference procedure for the difference of the model median between treatment groups at the specified occasion in the context of mixed effects models for repeated measures analysis for randomized clinical trials, which provided interpretable estimates of the treatment effect. From simulation studies, it was shown that our proposed method controlled type I error of the statistical test for the model median difference in almost all the situations and had moderate or high performance for power compared with the existing methods. We illustrated our method with cluster of differentiation 4 (CD4) data in an AIDS clinical trial, where the interpretability of the analysis results based on our proposed method is demonstrated. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  9. A brief introduction to regression designs and mixed-effects modelling by a recent convert

    DEFF Research Database (Denmark)

    Balling, Laura Winther

    2008-01-01

    This article discusses the advantages of multiple regression designs over the factorial designs traditionally used in many psycholinguistic experiments. It is shown that regression designs are typically more informative, statistically more powerful and better suited to the analysis of naturalistic...... tasks. The advantages of including both fixed and random effects are demonstrated with reference to linear mixed-effects models, and problems of collinearity, variable distribution and variable selection are discussed. The advantages of these techniques are exemplified in an analysis of a word...

  10. Mixed effects modeling of proliferation rates in cell-based models: consequence for pharmacogenomics and cancer.

    Directory of Open Access Journals (Sweden)

    Hae Kyung Im

    2012-02-01

    Full Text Available The International HapMap project has made publicly available extensive genotypic data on a number of lymphoblastoid cell lines (LCLs. Building on this resource, many research groups have generated a large amount of phenotypic data on these cell lines to facilitate genetic studies of disease risk or drug response. However, one problem that may reduce the usefulness of these resources is the biological noise inherent to cellular phenotypes. We developed a novel method, termed Mixed Effects Model Averaging (MEM, which pools data from multiple sources and generates an intrinsic cellular growth rate phenotype. This intrinsic growth rate was estimated for each of over 500 HapMap cell lines. We then examined the association of this intrinsic growth rate with gene expression levels and found that almost 30% (2,967 out of 10,748 of the genes tested were significant with FDR less than 10%. We probed further to demonstrate evidence of a genetic effect on intrinsic growth rate by determining a significant enrichment in growth-associated genes among genes targeted by top growth-associated SNPs (as eQTLs. The estimated intrinsic growth rate as well as the strength of the association with genetic variants and gene expression traits are made publicly available through a cell-based pharmacogenomics database, PACdb. This resource should enable researchers to explore the mediating effects of proliferation rate on other phenotypes.

  11. Bias and inference from misspecified mixed-effect models in stepped wedge trial analysis.

    Science.gov (United States)

    Thompson, Jennifer A; Fielding, Katherine L; Davey, Calum; Aiken, Alexander M; Hargreaves, James R; Hayes, Richard J

    2017-10-15

    Many stepped wedge trials (SWTs) are analysed by using a mixed-effect model with a random intercept and fixed effects for the intervention and time periods (referred to here as the standard model). However, it is not known whether this model is robust to misspecification. We simulated SWTs with three groups of clusters and two time periods; one group received the intervention during the first period and two groups in the second period. We simulated period and intervention effects that were either common-to-all or varied-between clusters. Data were analysed with the standard model or with additional random effects for period effect or intervention effect. In a second simulation study, we explored the weight given to within-cluster comparisons by simulating a larger intervention effect in the group of the trial that experienced both the control and intervention conditions and applying the three analysis models described previously. Across 500 simulations, we computed bias and confidence interval coverage of the estimated intervention effect. We found up to 50% bias in intervention effect estimates when period or intervention effects varied between clusters and were treated as fixed effects in the analysis. All misspecified models showed undercoverage of 95% confidence intervals, particularly the standard model. A large weight was given to within-cluster comparisons in the standard model. In the SWTs simulated here, mixed-effect models were highly sensitive to departures from the model assumptions, which can be explained by the high dependence on within-cluster comparisons. Trialists should consider including a random effect for time period in their SWT analysis model. © 2017 The Authors. Statistics in Medicine published by John Wiley & Sons Ltd. © 2017 The Authors. Statistics in Medicine published by John Wiley & Sons Ltd.

  12. Identification of nonlinear anelastic models

    International Nuclear Information System (INIS)

    Draganescu, G E; Bereteu, L; Ercuta, A

    2008-01-01

    A useful nonlinear identification technique applied to the anelastic and rheologic models is presented in this paper. First introduced by Feldman, the method is based on the Hilbert transform, and is currently used for identification of the nonlinear vibrations

  13. Spatial variability in floodplain sedimentation: the use of generalized linear mixed-effects models

    Directory of Open Access Journals (Sweden)

    A. Cabezas

    2010-08-01

    Full Text Available Sediment, Total Organic Carbon (TOC and total nitrogen (TN accumulation during one overbank flood (1.15 y return interval were examined at one reach of the Middle Ebro River (NE Spain for elucidating spatial patterns. To achieve this goal, four areas with different geomorphological features and located within the study reach were examined by using artificial grass mats. Within each area, 1 m2 study plots consisting of three pseudo-replicates were placed in a semi-regular grid oriented perpendicular to the main channel. TOC, TN and Particle-Size composition of deposited sediments were examined and accumulation rates estimated. Generalized linear mixed-effects models were used to analyze sedimentation patterns in order to handle clustered sampling units, specific-site effects and spatial self-correlation between observations. Our results confirm the importance of channel-floodplain morphology and site micro-topography in explaining sediment, TOC and TN deposition patterns, although the importance of other factors as vegetation pattern should be included in further studies to explain small-scale variability. Generalized linear mixed-effect models provide a good framework to deal with the high spatial heterogeneity of this phenomenon at different spatial scales, and should be further investigated in order to explore its validity when examining the importance of factors such as flood magnitude or suspended sediment concentration.

  14. Design and analysis of Q-RT-PCR assays for haematological malignancies using mixed effects models

    DEFF Research Database (Denmark)

    Bøgsted, Martin; Mandrup, Charlotte; Petersen, Anders

    2009-01-01

    research use and needs qualit control for accuracy and precision. Especially the identification of experimental variations and statistical analysis has recently created discussions. The standard analytical technique is to use the Delta-Delta-Ct method. Although this method accounts for sample specific...... developed based on a linear mixed effects model for factorial designs. The model consists of an analysis of variance where the variation of each fixed effect of interest and identified experimental and biological nuisance variations are split. Hereby it accounts for varying efficiency, inhomogeneous......The recent WHO classification of haematological malignancies includes detection of genetic abnormalities with rognostic significance. Consequently, an increasing number of specific real-time quantitative reverse transcription polymerase chain reaction (Q-RT-PCR) based assays are in clinical...

  15. Bayesian inference for two-part mixed-effects model using skew distributions, with application to longitudinal semicontinuous alcohol data.

    Science.gov (United States)

    Xing, Dongyuan; Huang, Yangxin; Chen, Henian; Zhu, Yiliang; Dagne, Getachew A; Baldwin, Julie

    2017-08-01

    Semicontinuous data featured with an excessive proportion of zeros and right-skewed continuous positive values arise frequently in practice. One example would be the substance abuse/dependence symptoms data for which a substantial proportion of subjects investigated may report zero. Two-part mixed-effects models have been developed to analyze repeated measures of semicontinuous data from longitudinal studies. In this paper, we propose a flexible two-part mixed-effects model with skew distributions for correlated semicontinuous alcohol data under the framework of a Bayesian approach. The proposed model specification consists of two mixed-effects models linked by the correlated random effects: (i) a model on the occurrence of positive values using a generalized logistic mixed-effects model (Part I); and (ii) a model on the intensity of positive values using a linear mixed-effects model where the model errors follow skew distributions including skew- t and skew-normal distributions (Part II). The proposed method is illustrated with an alcohol abuse/dependence symptoms data from a longitudinal observational study, and the analytic results are reported by comparing potential models under different random-effects structures. Simulation studies are conducted to assess the performance of the proposed models and method.

  16. [Application of Mixed-effect Model in PMI Estimation by Vitreous Humor].

    Science.gov (United States)

    Yang, M Z; Li, H J; Zhang, T Y; Ding, Z J; Wu, S F; Qiu, X G; Liu, Q

    2018-02-01

    To test the changes of the potassium (K⁺) and magnesium (Mg²⁺) concentrations in vitreous humor of rabbits along with postmortem interval (PMI) under different temperatures, and explore the feasibility of PMI estimation using mixed-effect model. After sacrifice, rabbit carcasses were preserved at 5 ℃, 15 ℃, 25 ℃ and 35 ℃, and 80-100 μL of vitreous humor was collected by the double-eye alternating micro-sampling method at every 12 h. The concentrations of K⁺ and Mg²⁺ in vitreous humor were measured by a biochemical-immune analyser. The mixed-effect model was used to perform analysis and fitting, and established the equations for PMI estimation. The data detected from the samples that were stoned at 10 ℃, 20 ℃ and 30 ℃ with 20, 40 and 65 h were used to validate the equations of PMI estimation. The concentrations of K⁺ and Mg²⁺ [f( x , y )] in vitreous humor of rabbits under different temperature increased along with PMI ( x ). The relative equations of K⁺ and Mg²⁺ concentration with PMI and temperature under 5 ℃~35 ℃ were f K⁺ ( x , y )=3.413 0+0.309 2 x +0.337 6 y +0.010 83 xy -0.002 47 x ² ( P PMI estimation by K⁺ and Mg²⁺ was in 10 h when PMI was between 0 to 40 h, and the time of deviation was in 21 h when PMI was between 40 to 65 h. the ambient temperature range of 5 ℃-35 ℃, the mixed-effect model based on temperature and vitreous humor substance concentrations can provide a new method for the practical application of vitreous humor chemicals for PMI estimation. Copyright© by the Editorial Department of Journal of Forensic Medicine.

  17. Reduced Rank Mixed Effects Models for Spatially Correlated Hierarchical Functional Data

    KAUST Repository

    Zhou, Lan

    2010-03-01

    Hierarchical functional data are widely seen in complex studies where sub-units are nested within units, which in turn are nested within treatment groups. We propose a general framework of functional mixed effects model for such data: within unit and within sub-unit variations are modeled through two separate sets of principal components; the sub-unit level functions are allowed to be correlated. Penalized splines are used to model both the mean functions and the principal components functions, where roughness penalties are used to regularize the spline fit. An EM algorithm is developed to fit the model, while the specific covariance structure of the model is utilized for computational efficiency to avoid storage and inversion of large matrices. Our dimension reduction with principal components provides an effective solution to the difficult tasks of modeling the covariance kernel of a random function and modeling the correlation between functions. The proposed methodology is illustrated using simulations and an empirical data set from a colon carcinogenesis study. Supplemental materials are available online.

  18. Personalized prediction of chronic wound healing: an exponential mixed effects model using stereophotogrammetric measurement.

    Science.gov (United States)

    Xu, Yifan; Sun, Jiayang; Carter, Rebecca R; Bogie, Kath M

    2014-05-01

    Stereophotogrammetric digital imaging enables rapid and accurate detailed 3D wound monitoring. This rich data source was used to develop a statistically validated model to provide personalized predictive healing information for chronic wounds. 147 valid wound images were obtained from a sample of 13 category III/IV pressure ulcers from 10 individuals with spinal cord injury. Statistical comparison of several models indicated the best fit for the clinical data was a personalized mixed-effects exponential model (pMEE), with initial wound size and time as predictors and observed wound size as the response variable. Random effects capture personalized differences. Other models are only valid when wound size constantly decreases. This is often not achieved for clinical wounds. Our model accommodates this reality. Two criteria to determine effective healing time outcomes are proposed: r-fold wound size reduction time, t(r-fold), is defined as the time when wound size reduces to 1/r of initial size. t(δ) is defined as the time when the rate of the wound healing/size change reduces to a predetermined threshold δ current model improves with each additional evaluation. Routine assessment of wounds using detailed stereophotogrammetric imaging can provide personalized predictions of wound healing time. Application of a valid model will help the clinical team to determine wound management care pathways. Published by Elsevier Ltd.

  19. A Bayesian Approach to Functional Mixed Effect Modeling for Longitudinal Data with Binomial Outcomes

    Science.gov (United States)

    Kliethermes, Stephanie; Oleson, Jacob

    2014-01-01

    Longitudinal growth patterns are routinely seen in medical studies where individual and population growth is followed over a period of time. Many current methods for modeling growth presuppose a parametric relationship between the outcome and time (e.g., linear, quadratic); however, these relationships may not accurately capture growth over time. Functional mixed effects (FME) models provide flexibility in handling longitudinal data with nonparametric temporal trends. Although FME methods are well-developed for continuous, normally distributed outcome measures, nonparametric methods for handling categorical outcomes are limited. We consider the situation with binomially distributed longitudinal outcomes. Although percent correct data can be modeled assuming normality, estimates outside the parameter space are possible and thus estimated curves can be unrealistic. We propose a binomial FME model using Bayesian methodology to account for growth curves with binomial (percentage) outcomes. The usefulness of our methods is demonstrated using a longitudinal study of speech perception outcomes from cochlear implant users where we successfully model both the population and individual growth trajectories. Simulation studies also advocate the usefulness of the binomial model particularly when outcomes occur near the boundary of the probability parameter space and in situations with a small number of trials. PMID:24723495

  20. A Bayesian approach to functional mixed-effects modeling for longitudinal data with binomial outcomes.

    Science.gov (United States)

    Kliethermes, Stephanie; Oleson, Jacob

    2014-08-15

    Longitudinal growth patterns are routinely seen in medical studies where individual growth and population growth are followed up over a period of time. Many current methods for modeling growth presuppose a parametric relationship between the outcome and time (e.g., linear and quadratic); however, these relationships may not accurately capture growth over time. Functional mixed-effects (FME) models provide flexibility in handling longitudinal data with nonparametric temporal trends. Although FME methods are well developed for continuous, normally distributed outcome measures, nonparametric methods for handling categorical outcomes are limited. We consider the situation with binomially distributed longitudinal outcomes. Although percent correct data can be modeled assuming normality, estimates outside the parameter space are possible, and thus, estimated curves can be unrealistic. We propose a binomial FME model using Bayesian methodology to account for growth curves with binomial (percentage) outcomes. The usefulness of our methods is demonstrated using a longitudinal study of speech perception outcomes from cochlear implant users where we successfully model both the population and individual growth trajectories. Simulation studies also advocate the usefulness of the binomial model particularly when outcomes occur near the boundary of the probability parameter space and in situations with a small number of trials. Copyright © 2014 John Wiley & Sons, Ltd.

  1. Modeling the oxygen uptake kinetics during exercise testing of patients with chronic obstructive pulmonary diseases using nonlinear mixed models

    DEFF Research Database (Denmark)

    Baty, Florent; Ritz, Christian; van Gestel, Arnoldus

    2016-01-01

    describe functionality of the R package medrc that extends the framework of the commonly used packages drc and nlme and allows fitting nonlinear mixed effects models for automated nonlinear regression modeling. The methodology was applied to a data set including 6MWT [Formula: see text]O2 kinetics from 61...... patients with chronic obstructive pulmonary disease (disease severity stage II to IV). The mixed effects approach was compared to a traditional curve-by-curve approach. RESULTS: A six-parameter nonlinear regression model was jointly fitted to the set of [Formula: see text]O2 kinetics. Significant...

  2. LDRD report nonlinear model reduction

    Energy Technology Data Exchange (ETDEWEB)

    Segalman, D.; Heinstein, M.

    1997-09-01

    The very general problem of model reduction of nonlinear systems was made tractable by focusing on the very large subclass consisting of linear subsystems connected by nonlinear interfaces. Such problems constitute a large part of the nonlinear structural problems encountered in addressing the Sandia missions. A synthesis approach to this class of problems was developed consisting of: detailed modeling of the interface mechanics; collapsing the interface simulation results into simple nonlinear interface models; constructing system models by assembling model approximations of the linear subsystems and the nonlinear interface models. These system models, though nonlinear, would have very few degrees of freedom. A paradigm problem, that of machine tool vibration, was selected for application of the reduction approach outlined above. Research results achieved along the way as well as the overall modeling of a specific machine tool have been very encouraging. In order to confirm the interface models resulting from simulation, it was necessary to develop techniques to deduce interface mechanics from experimental data collected from the overall nonlinear structure. A program to develop such techniques was also pursued with good success.

  3. Modelling the multilevel structure and mixed effects of the factors influencing the energy consumption of electric vehicles

    International Nuclear Information System (INIS)

    Liu, Kai; Wang, Jiangbo; Yamamoto, Toshiyuki; Morikawa, Takayuki

    2016-01-01

    Highlights: • The impacts of driving heterogeneity on EVs’ energy efficiency are examined. • Several multilevel mixed-effects regression models are proposed and compared. • The most reasonable nested structure is extracted from the long term GPS data. • Proposed model improves the energy estimation accuracy by 7.5%. - Abstract: To improve the accuracy of estimation of the energy consumption of electric vehicles (EVs) and to enable the alleviation of range anxiety through the introduction of EV charging stations at suitable locations for the near future, multilevel mixed-effects linear regression models were used in this study to estimate the actual energy efficiency of EVs. The impacts of the heterogeneity in driving behaviour among various road environments and traffic conditions on EV energy efficiency were extracted from long-term daily trip-based energy consumption data, which were collected over 12 months from 68 in-use EVs in Aichi Prefecture in Japan. Considering the variations in energy efficiency associated with different types of EV ownership, different external environments, and different driving habits, a two-level random intercept model, three two-level mixed-effects models, and two three-level mixed-effects models were developed and compared. The most reasonable nesting structure was determined by comparing the models, which were designed with different nesting structures and different random variance component specifications, thereby revealing the potential correlations and non-constant variability of the energy consumption per kilometre (ECPK) and improving the estimation accuracy by 7.5%.

  4. Translational mixed-effects PKPD modelling of recombinant human growth hormone - from hypophysectomized rat to patients

    DEFF Research Database (Denmark)

    Thorsted, Anders; Thygesen, Peter; Agersø, Henrik

    2016-01-01

    was developed from experimental PKPD studies of rhGH and effects of long-term treatment as measured by insulin-like growth factor 1 (IGF-1) and bodyweight gain in rats. Modelled parameter values were scaled to human values using the allometric approach with fixed exponents for PKs and unscaled for PDs...... and validated through simulations relative to patient data. KEY RESULTS: The final model described rhGH PK as a two compartmental model with parallel linear and non-linear elimination terms, parallel first-order absorption with a total s.c. bioavailability of 87% in rats. Induction of IGF-1 was described...... by an indirect response model with stimulation of kin and related to rhGH exposure through an Emax relationship. Increase in bodyweight was directly linked to individual concentrations of IGF-1 by a linear relation. The scaled model provided robust predictions of human systemic PK of rhGH, but exposure following...

  5. Non-linear Growth Models in Mplus and SAS

    Science.gov (United States)

    Grimm, Kevin J.; Ram, Nilam

    2013-01-01

    Non-linear growth curves or growth curves that follow a specified non-linear function in time enable researchers to model complex developmental patterns with parameters that are easily interpretable. In this paper we describe how a variety of sigmoid curves can be fit using the Mplus structural modeling program and the non-linear mixed-effects modeling procedure NLMIXED in SAS. Using longitudinal achievement data collected as part of a study examining the effects of preschool instruction on academic gain we illustrate the procedures for fitting growth models of logistic, Gompertz, and Richards functions. Brief notes regarding the practical benefits, limitations, and choices faced in the fitting and estimation of such models are included. PMID:23882134

  6. Modeling nonlinearities in MEMS oscillators.

    Science.gov (United States)

    Agrawal, Deepak K; Woodhouse, Jim; Seshia, Ashwin A

    2013-08-01

    We present a mathematical model of a microelectromechanical system (MEMS) oscillator that integrates the nonlinearities of the MEMS resonator and the oscillator circuitry in a single numerical modeling environment. This is achieved by transforming the conventional nonlinear mechanical model into the electrical domain while simultaneously considering the prominent nonlinearities of the resonator. The proposed nonlinear electrical model is validated by comparing the simulated amplitude-frequency response with measurements on an open-loop electrically addressed flexural silicon MEMS resonator driven to large motional amplitudes. Next, the essential nonlinearities in the oscillator circuit are investigated and a mathematical model of a MEMS oscillator is proposed that integrates the nonlinearities of the resonator. The concept is illustrated for MEMS transimpedance-amplifier- based square-wave and sine-wave oscillators. Closed-form expressions of steady-state output power and output frequency are derived for both oscillator models and compared with experimental and simulation results, with a good match in the predicted trends in all three cases.

  7. Dialectical behavior therapy for borderline personality disorder: a meta-analysis using mixed-effects modeling.

    Science.gov (United States)

    Kliem, Sören; Kröger, Christoph; Kosfelder, Joachim

    2010-12-01

    At present, the most frequently investigated psychosocial intervention for borderline personality disorder (BPD) is dialectical behavior therapy (DBT). We conducted a meta-analysis to examine the efficacy and long-term effectiveness of DBT. Systematic bibliographic research was undertaken to find relevant literature from online databases (PubMed, PsycINFO, PsychSpider, Medline). We excluded studies in which patients with diagnoses other than BPD were treated, the treatment did not comprise all components specified in the DBT manual or in the suggestions for inpatient DBT programs, patients failed to be diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, and the intervention group comprised fewer than 10 patients. Using a mixed-effect hierarchical modeling approach, we calculated global effect sizes and effect sizes for suicidal and self-injurious behaviors. Calculations of postintervention global effect sizes were based on 16 studies. Of these, 8 were randomized controlled trials (RCTs), and 8 were neither randomized nor controlled (nRCT). The dropout rate was 27.3% pre- to posttreatment. A moderate global effect and a moderate effect size for suicidal and self-injurious behaviors were found, when including a moderator for RCTs with borderline-specific treatments. There was no evidence for the influence of other moderators (e.g., quality of studies, setting, duration of intervention). A small impairment was shown from posttreatment to follow-up, including 5 RCTs only. Future research should compare DBT with other active borderline-specific treatments that have also demonstrated their efficacy using several long-term follow-up assessment points. (c) 2010 APA, all rights reserved.

  8. Mixed-effects models for estimating stand volume by means of small footprint airborne laser scanner data.

    Science.gov (United States)

    J. Breidenbach; E. Kublin; R. McGaughey; H.-E. Andersen; S. Reutebuch

    2008-01-01

    For this study, hierarchical data sets--in that several sample plots are located within a stand--were analyzed for study sites in the USA and Germany. The German data had an additional hierarchy as the stands are located within four distinct public forests. Fixed-effects models and mixed-effects models with a random intercept on the stand level were fit to each data...

  9. Population stochastic modelling (PSM)-An R package for mixed-effects models based on stochastic differential equations

    DEFF Research Database (Denmark)

    Klim, Søren; Mortensen, Stig Bousgaard; Kristensen, Niels Rode

    2009-01-01

    are often partly ignored in PK/PD modelling although violating the hypothesis for many standard statistical tests. This article presents a package for the statistical program R that is able to handle SDEs in a mixed-effects setting. The estimation method implemented is the FOCE1 approximation......The extension from ordinary to stochastic differential equations (SDEs) in pharmacokinetic and pharmacodynamic (PK/PD) modelling is an emerging field and has been motivated in a number of articles [N.R. Kristensen, H. Madsen, S.H. Ingwersen, Using stochastic differential equations for PK/PD model...... development, J. Pharmacokinet. Pharmacodyn. 32 (February(l)) (2005) 109-141; C.W. Tornoe, R.V Overgaard, H. Agerso, H.A. Nielsen, H. Madsen, E.N. Jonsson, Stochastic differential equations in NONMEM: implementation, application, and comparison with ordinary differential equations, Pharm. Res. 22 (August(8...

  10. Nonlinear Modeling by Assembling Piecewise Linear Models

    Science.gov (United States)

    Yao, Weigang; Liou, Meng-Sing

    2013-01-01

    To preserve nonlinearity of a full order system over a parameters range of interest, we propose a simple modeling approach by assembling a set of piecewise local solutions, including the first-order Taylor series terms expanded about some sampling states. The work by Rewienski and White inspired our use of piecewise linear local solutions. The assembly of these local approximations is accomplished by assigning nonlinear weights, through radial basis functions in this study. The efficacy of the proposed procedure is validated for a two-dimensional airfoil moving at different Mach numbers and pitching motions, under which the flow exhibits prominent nonlinear behaviors. All results confirm that our nonlinear model is accurate and stable for predicting not only aerodynamic forces but also detailed flowfields. Moreover, the model is robustness-accurate for inputs considerably different from the base trajectory in form and magnitude. This modeling preserves nonlinearity of the problems considered in a rather simple and accurate manner.

  11. The transition model test for serial dependence in mixed-effects models for binary data

    DEFF Research Database (Denmark)

    Breinegaard, Nina; Rabe-Hesketh, Sophia; Skrondal, Anders

    2017-01-01

    Generalized linear mixed models for longitudinal data assume that responses at different occasions are conditionally independent, given the random effects and covariates. Although this assumption is pivotal for consistent estimation, violation due to serial dependence is hard to assess by model...

  12. Linear mixed-effects models for within-participant psychology experiments: an introductory tutorial and free, graphical user interface (LMMgui).

    Science.gov (United States)

    Magezi, David A

    2015-01-01

    Linear mixed-effects models (LMMs) are increasingly being used for data analysis in cognitive neuroscience and experimental psychology, where within-participant designs are common. The current article provides an introductory review of the use of LMMs for within-participant data analysis and describes a free, simple, graphical user interface (LMMgui). LMMgui uses the package lme4 (Bates et al., 2014a,b) in the statistical environment R (R Core Team).

  13. Nonlinear Control of Heartbeat Models

    Directory of Open Access Journals (Sweden)

    Witt Thanom

    2011-02-01

    Full Text Available This paper presents a novel application of nonlinear control theory to heartbeat models. Existing heartbeat models are investigated and modified by incorporating the control input as a pacemaker to provide the control channel. A nonlinear feedback linearization technique is applied to force the output of the systems to generate artificial electrocardiogram (ECG signal using discrete data as the reference inputs. The synthetic ECG may serve as a flexible signal source to assess the effectiveness of a diagnostic ECG signal-processing device.

  14. Bayesian quantile regression-based partially linear mixed-effects joint models for longitudinal data with multiple features.

    Science.gov (United States)

    Zhang, Hanze; Huang, Yangxin; Wang, Wei; Chen, Henian; Langland-Orban, Barbara

    2017-01-01

    In longitudinal AIDS studies, it is of interest to investigate the relationship between HIV viral load and CD4 cell counts, as well as the complicated time effect. Most of common models to analyze such complex longitudinal data are based on mean-regression, which fails to provide efficient estimates due to outliers and/or heavy tails. Quantile regression-based partially linear mixed-effects models, a special case of semiparametric models enjoying benefits of both parametric and nonparametric models, have the flexibility to monitor the viral dynamics nonparametrically and detect the varying CD4 effects parametrically at different quantiles of viral load. Meanwhile, it is critical to consider various data features of repeated measurements, including left-censoring due to a limit of detection, covariate measurement error, and asymmetric distribution. In this research, we first establish a Bayesian joint models that accounts for all these data features simultaneously in the framework of quantile regression-based partially linear mixed-effects models. The proposed models are applied to analyze the Multicenter AIDS Cohort Study (MACS) data. Simulation studies are also conducted to assess the performance of the proposed methods under different scenarios.

  15. Fitting and Calibrating a Multilevel Mixed-Effects Stem Taper Model for Maritime Pine in NW Spain

    Science.gov (United States)

    Arias-Rodil, Manuel; Castedo-Dorado, Fernando; Cámara-Obregón, Asunción; Diéguez-Aranda, Ulises

    2015-01-01

    Stem taper data are usually hierarchical (several measurements per tree, and several trees per plot), making application of a multilevel mixed-effects modelling approach essential. However, correlation between trees in the same plot/stand has often been ignored in previous studies. Fitting and calibration of a variable-exponent stem taper function were conducted using data from 420 trees felled in even-aged maritime pine (Pinus pinaster Ait.) stands in NW Spain. In the fitting step, the tree level explained much more variability than the plot level, and therefore calibration at plot level was omitted. Several stem heights were evaluated for measurement of the additional diameter needed for calibration at tree level. Calibration with an additional diameter measured at between 40 and 60% of total tree height showed the greatest improvement in volume and diameter predictions. If additional diameter measurement is not available, the fixed-effects model fitted by the ordinary least squares technique should be used. Finally, we also evaluated how the expansion of parameters with random effects affects the stem taper prediction, as we consider this a key question when applying the mixed-effects modelling approach to taper equations. The results showed that correlation between random effects should be taken into account when assessing the influence of random effects in stem taper prediction. PMID:26630156

  16. Mixed-Effects Modeling of Neurofeedback Self-Regulation Performance: Moderators for Learning in Children with ADHD.

    Science.gov (United States)

    Zuberer, Agnieszka; Minder, Franziska; Brandeis, Daniel; Drechsler, Renate

    2018-01-01

    Neurofeedback (NF) has gained increasing popularity as a training method for children and adults with attention deficit hyperactivity disorder (ADHD). However, it is unclear to what extent children learn to regulate their brain activity and in what way NF learning may be affected by subject- and treatment-related factors. In total, 48 subjects with ADHD (age 8.5-16.5 years; 16 subjects on methylphenidate (MPH)) underwent 15 double training sessions of NF in either a clinical or a school setting. Four mixed-effects models were employed to analyze learning: training within-sessions, across-sessions, with continuous feedback, and with transfer in which performance feedback is delayed. Age and MPH affected the NF performance in all models. Cross-session learning in the feedback condition was mainly moderated by age and MPH, whereas NF learning in the transfer condition was mainly boosted by MPH. Apart from IQ and task types, other subject-related or treatment-related effects were unrelated to NF learning. This first study analyzing moderators of NF learning in ADHD with a mixed-effects modeling approach shows that NF performance is moderated differentially by effects of age and MPH depending on the training task and time window. Future studies may benefit from using this approach to analyze NF learning and NF specificity. The trial name Neurofeedback and Computerized Cognitive Training in Different Settings for Children and Adolescents With ADHD is registered with NCT02358941.

  17. Modelling Loudspeaker Non-Linearities

    DEFF Research Database (Denmark)

    Agerkvist, Finn T.

    2007-01-01

    This paper investigates different techniques for modelling the non-linear parameters of the electrodynamic loudspeaker. The methods are tested not only for their accuracy within the range of original data, but also for the ability to work reasonable outside that range, and it is demonstrated...... that polynomial expansions are rather poor at this, whereas an inverse polynomial expansion or localized fitting functions such as the gaussian are better suited for modelling the Bl-factor and compliance. For the inductance the sigmoid function is shown to give very good results. Finally the time varying...

  18. Modeling Individual Differences in Within-Person Variation of Negative and Positive Affect in a Mixed Effects Location Scale Model Using BUGS/JAGS

    Science.gov (United States)

    Rast, Philippe; Hofer, Scott M.; Sparks, Catharine

    2012-01-01

    A mixed effects location scale model was used to model and explain individual differences in within-person variability of negative and positive affect across 7 days (N=178) within a measurement burst design. The data come from undergraduate university students and are pooled from a study that was repeated at two consecutive years. Individual…

  19. Estimation methods for nonlinear state-space models in ecology

    DEFF Research Database (Denmark)

    Pedersen, Martin Wæver; Berg, Casper Willestofte; Thygesen, Uffe Høgsbro

    2011-01-01

    The use of nonlinear state-space models for analyzing ecological systems is increasing. A wide range of estimation methods for such models are available to ecologists, however it is not always clear, which is the appropriate method to choose. To this end, three approaches to estimation in the theta...... logistic model for population dynamics were benchmarked by Wang (2007). Similarly, we examine and compare the estimation performance of three alternative methods using simulated data. The first approach is to partition the state-space into a finite number of states and formulate the problem as a hidden...... Markov model (HMM). The second method uses the mixed effects modeling and fast numerical integration framework of the AD Model Builder (ADMB) open-source software. The third alternative is to use the popular Bayesian framework of BUGS. The study showed that state and parameter estimation performance...

  20. Linear mixed-effects models to describe individual tree crown width for China-fir in Fujian Province, southeast China.

    Science.gov (United States)

    Hao, Xu; Yujun, Sun; Xinjie, Wang; Jin, Wang; Yao, Fu

    2015-01-01

    A multiple linear model was developed for individual tree crown width of Cunninghamia lanceolata (Lamb.) Hook in Fujian province, southeast China. Data were obtained from 55 sample plots of pure China-fir plantation stands. An Ordinary Linear Least Squares (OLS) regression was used to establish the crown width model. To adjust for correlations between observations from the same sample plots, we developed one level linear mixed-effects (LME) models based on the multiple linear model, which take into account the random effects of plots. The best random effects combinations for the LME models were determined by the Akaike's information criterion, the Bayesian information criterion and the -2logarithm likelihood. Heteroscedasticity was reduced by three residual variance functions: the power function, the exponential function and the constant plus power function. The spatial correlation was modeled by three correlation structures: the first-order autoregressive structure [AR(1)], a combination of first-order autoregressive and moving average structures [ARMA(1,1)], and the compound symmetry structure (CS). Then, the LME model was compared to the multiple linear model using the absolute mean residual (AMR), the root mean square error (RMSE), and the adjusted coefficient of determination (adj-R2). For individual tree crown width models, the one level LME model showed the best performance. An independent dataset was used to test the performance of the models and to demonstrate the advantage of calibrating LME models.

  1. Adaptive regression for modeling nonlinear relationships

    CERN Document Server

    Knafl, George J

    2016-01-01

    This book presents methods for investigating whether relationships are linear or nonlinear and for adaptively fitting appropriate models when they are nonlinear. Data analysts will learn how to incorporate nonlinearity in one or more predictor variables into regression models for different types of outcome variables. Such nonlinear dependence is often not considered in applied research, yet nonlinear relationships are common and so need to be addressed. A standard linear analysis can produce misleading conclusions, while a nonlinear analysis can provide novel insights into data, not otherwise possible. A variety of examples of the benefits of modeling nonlinear relationships are presented throughout the book. Methods are covered using what are called fractional polynomials based on real-valued power transformations of primary predictor variables combined with model selection based on likelihood cross-validation. The book covers how to formulate and conduct such adaptive fractional polynomial modeling in the s...

  2. Measuring the individual benefit of a medical or behavioral treatment using generalized linear mixed-effects models.

    Science.gov (United States)

    Diaz, Francisco J

    2016-10-15

    We propose statistical definitions of the individual benefit of a medical or behavioral treatment and of the severity of a chronic illness. These definitions are used to develop a graphical method that can be used by statisticians and clinicians in the data analysis of clinical trials from the perspective of personalized medicine. The method focuses on assessing and comparing individual effects of treatments rather than average effects and can be used with continuous and discrete responses, including dichotomous and count responses. The method is based on new developments in generalized linear mixed-effects models, which are introduced in this article. To illustrate, analyses of data from the Sequenced Treatment Alternatives to Relieve Depression clinical trial of sequences of treatments for depression and data from a clinical trial of respiratory treatments are presented. The estimation of individual benefits is also explained. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  3. Nonlinear models for autoregressive conditional heteroskedasticity

    DEFF Research Database (Denmark)

    Teräsvirta, Timo

    This paper contains a brief survey of nonlinear models of autore- gressive conditional heteroskedasticity. The models in question are parametric nonlinear extensions of the original model by Engle (1982). After presenting the individual models, linearity testing and parameter estimation are discu...

  4. Relation between nonlinear models and gauge ambiguities

    International Nuclear Information System (INIS)

    Balachandran, A.P.; Ramachandran, R.; Rupertsberger, H.; Skagerstam, B.S.

    1980-01-01

    We show that the solutions of a class of nonlinear models also generate gauge ambiguities in the vacuum sector of Yang-Mills theories. Our results extend known connections between gauge ambiguities and certain nonlinear sigma-models, and clarify the underlying group theory. For many nonlinear models, we also give a simple, intrinsic parametrization of physical fields (which have values in a homogeneous space of a group). (orig.)

  5. A Mixed-Effects Heterogeneous Negative Binomial Model for Postfire Conifer Regeneration in Northeastern California, USA

    Science.gov (United States)

    Justin S. Crotteau; Martin W. Ritchie; J. Morgan. Varner

    2014-01-01

    Many western USA fire regimes are typified by mixed-severity fire, which compounds the variability inherent to natural regeneration densities in associated forests. Tree regeneration data are often discrete and nonnegative; accordingly, we fit a series of Poisson and negative binomial variation models to conifer seedling counts across four distinct burn severities and...

  6. A multivariate multilevel Gaussian model with a mixed effects structure in the mean and covariance part.

    Science.gov (United States)

    Li, Baoyue; Bruyneel, Luk; Lesaffre, Emmanuel

    2014-05-20

    A traditional Gaussian hierarchical model assumes a nested multilevel structure for the mean and a constant variance at each level. We propose a Bayesian multivariate multilevel factor model that assumes a multilevel structure for both the mean and the covariance matrix. That is, in addition to a multilevel structure for the mean we also assume that the covariance matrix depends on covariates and random effects. This allows to explore whether the covariance structure depends on the values of the higher levels and as such models heterogeneity in the variances and correlation structure of the multivariate outcome across the higher level values. The approach is applied to the three-dimensional vector of burnout measurements collected on nurses in a large European study to answer the research question whether the covariance matrix of the outcomes depends on recorded system-level features in the organization of nursing care, but also on not-recorded factors that vary with countries, hospitals, and nursing units. Simulations illustrate the performance of our modeling approach. Copyright © 2013 John Wiley & Sons, Ltd.

  7. Superspace formulation of new nonlinear sigma models

    International Nuclear Information System (INIS)

    Gates, S.J. Jr.

    1983-07-01

    The superspace formulation of two classes of supersymmetric nonlinear σ-models are presented. Two alternative N=1 superspace formulations are given for the d=2 supersymmetric nonlinear σ-models with Killing vector potentials: (a) formulation uses an active central charge and, (b) formulation uses a spurion superfield without inducing a classical breakdown of supersymmetry. The N=2 vector multiplet is used to construct a new class of d=4 nonlinear σ-models which when reduced to d=2 possess N=4 supersymmetry. Implications of these two classes of nonlinear σ-models for N>=4 superfield supergravity are discussed. (author)

  8. Mixed-effects modelling of the interspecies pharmacokinetic scaling of pegylated human erythropoietin.

    Science.gov (United States)

    Jolling, Koen; Perez Ruixo, Juan Jose; Hemeryck, Alex; Vermeulen, An; Greway, Tony

    2005-04-01

    The aim of this study was to develop a population pharmacokinetic model for interspecies allometric scaling of pegylated r-HuEPO (PEG-EPO) pharmacokinetics to man. A total of 927 serum concentrations from 193 rats, 6 rabbits, 34 monkeys, and 9 dogs obtained after a single dose of PEG-EPO, administered by the i.v. (dose range: 12.5-550 microg/kg) and s.c. (dose range: 12.5-500 microg/kg) routes, were pooled in this analysis. An open two-compartment model with first-order absorption and lag time (Tlag) and linear elimination from the central compartment was fitted to the data using the NONMEM V software. Body weight (WT) was used as a scaling factor and the effect of brain weight (BW), sex, and pregnancy status on the pharmacokinetic parameters was investigated. The final model was evaluated by means of a non-parametric bootstrap analysis and used to predict the PEG-EPO pharmacokinetic parameters in healthy male subjects. The systemic clearance (CL) in males was estimated to be 4.08WT1.030xBW-0.345 ml/h. In females, the CL was 90.7% of the CL in males. The volumes of the central (Vc) and the peripheral (Vp) compartment were characterized as 57.8WT0.959 ml, and 48.1WT1.150 ml, respectively. Intercompartmental flow was estimated at 2.32WT0.930 ml/h. Absorption rate constant (Ka) was estimated at 0.0538WT-0.149. The absolute s.c. bioavailability F was calculated at 52.5, 80.2, and 49.4% in rat, monkey, and dog, respectively. The interindividual variability in the population pharmacokinetic parameters was fairly low (parametric bootstrap confirmed the accuracy of the NONMEM estimates. The mean model predicted pharmacokinetic parameters in healthy male subjects of 70 kg were estimated at: CL: 26.2 ml/h; Vc: 3.6l; Q: 286 l/h; Vp: 6.9l, and Ka: 0.031 h-1. The population pharmacokinetic model developed was appropriate to describe the time course of PEG-EPO serum concentrations and their variability in different species. The model predicted pharmacokinetics of PEG-EPO in

  9. Mathematical modeling and applications in nonlinear dynamics

    CERN Document Server

    Merdan, Hüseyin

    2016-01-01

    The book covers nonlinear physical problems and mathematical modeling, including molecular biology, genetics, neurosciences, artificial intelligence with classical problems in mechanics and astronomy and physics. The chapters present nonlinear mathematical modeling in life science and physics through nonlinear differential equations, nonlinear discrete equations and hybrid equations. Such modeling can be effectively applied to the wide spectrum of nonlinear physical problems, including the KAM (Kolmogorov-Arnold-Moser (KAM)) theory, singular differential equations, impulsive dichotomous linear systems, analytical bifurcation trees of periodic motions, and almost or pseudo- almost periodic solutions in nonlinear dynamical systems. Provides methods for mathematical models with switching, thresholds, and impulses, each of particular importance for discontinuous processes Includes qualitative analysis of behaviors on Tumor-Immune Systems and methods of analysis for DNA, neural networks and epidemiology Introduces...

  10. Using Poisson mixed-effects model to quantify transcript-level gene expression in RNA-Seq.

    Science.gov (United States)

    Hu, Ming; Zhu, Yu; Taylor, Jeremy M G; Liu, Jun S; Qin, Zhaohui S

    2012-01-01

    RNA sequencing (RNA-Seq) is a powerful new technology for mapping and quantifying transcriptomes using ultra high-throughput next-generation sequencing technologies. Using deep sequencing, gene expression levels of all transcripts including novel ones can be quantified digitally. Although extremely promising, the massive amounts of data generated by RNA-Seq, substantial biases and uncertainty in short read alignment pose challenges for data analysis. In particular, large base-specific variation and between-base dependence make simple approaches, such as those that use averaging to normalize RNA-Seq data and quantify gene expressions, ineffective. In this study, we propose a Poisson mixed-effects (POME) model to characterize base-level read coverage within each transcript. The underlying expression level is included as a key parameter in this model. Since the proposed model is capable of incorporating base-specific variation as well as between-base dependence that affect read coverage profile throughout the transcript, it can lead to improved quantification of the true underlying expression level. POME can be freely downloaded at http://www.stat.purdue.edu/~yuzhu/pome.html. yuzhu@purdue.edu; zhaohui.qin@emory.edu Supplementary data are available at Bioinformatics online.

  11. Predicting the multi-domain progression of Parkinson's disease: a Bayesian multivariate generalized linear mixed-effect model.

    Science.gov (United States)

    Wang, Ming; Li, Zheng; Lee, Eun Young; Lewis, Mechelle M; Zhang, Lijun; Sterling, Nicholas W; Wagner, Daymond; Eslinger, Paul; Du, Guangwei; Huang, Xuemei

    2017-09-25

    It is challenging for current statistical models to predict clinical progression of Parkinson's disease (PD) because of the involvement of multi-domains and longitudinal data. Past univariate longitudinal or multivariate analyses from cross-sectional trials have limited power to predict individual outcomes or a single moment. The multivariate generalized linear mixed-effect model (GLMM) under the Bayesian framework was proposed to study multi-domain longitudinal outcomes obtained at baseline, 18-, and 36-month. The outcomes included motor, non-motor, and postural instability scores from the MDS-UPDRS, and demographic and standardized clinical data were utilized as covariates. The dynamic prediction was performed for both internal and external subjects using the samples from the posterior distributions of the parameter estimates and random effects, and also the predictive accuracy was evaluated based on the root of mean square error (RMSE), absolute bias (AB) and the area under the receiver operating characteristic (ROC) curve. First, our prediction model identified clinical data that were differentially associated with motor, non-motor, and postural stability scores. Second, the predictive accuracy of our model for the training data was assessed, and improved prediction was gained in particularly for non-motor (RMSE and AB: 2.89 and 2.20) compared to univariate analysis (RMSE and AB: 3.04 and 2.35). Third, the individual-level predictions of longitudinal trajectories for the testing data were performed, with ~80% observed values falling within the 95% credible intervals. Multivariate general mixed models hold promise to predict clinical progression of individual outcomes in PD. The data was obtained from Dr. Xuemei Huang's NIH grant R01 NS060722 , part of NINDS PD Biomarker Program (PDBP). All data was entered within 24 h of collection to the Data Management Repository (DMR), which is publically available ( https://pdbp.ninds.nih.gov/data-management ).

  12. Predictors for physical activity in adolescent girls using statistical shrinkage techniques for hierarchical longitudinal mixed effects models.

    Directory of Open Access Journals (Sweden)

    Edward M Grant

    Full Text Available We examined associations among longitudinal, multilevel variables and girls' physical activity to determine the important predictors for physical activity change at different adolescent ages. The Trial of Activity for Adolescent Girls 2 study (Maryland contributed participants from 8th (2009 to 11th grade (2011 (n=561. Questionnaires were used to obtain demographic, and psychosocial information (individual- and social-level variables; height, weight, and triceps skinfold to assess body composition; interviews and surveys for school-level data; and self-report for neighborhood-level variables. Moderate to vigorous physical activity minutes were assessed from accelerometers. A doubly regularized linear mixed effects model was used for the longitudinal multilevel data to identify the most important covariates for physical activity. Three fixed effects at the individual level and one random effect at the school level were chosen from an initial total of 66 variables, consisting of 47 fixed effects and 19 random effects variables, in additional to the time effect. Self-management strategies, perceived barriers, and social support from friends were the three selected fixed effects, and whether intramural or interscholastic programs were offered in middle school was the selected random effect. Psychosocial factors and friend support, plus a school's physical activity environment, affect adolescent girl's moderate to vigorous physical activity longitudinally.

  13. Non-linear finite element modeling

    DEFF Research Database (Denmark)

    Mikkelsen, Lars Pilgaard

    The note is written for courses in "Non-linear finite element method". The note has been used by the author teaching non-linear finite element modeling at Civil Engineering at Aalborg University, Computational Mechanics at Aalborg University Esbjerg, Structural Engineering at the University...

  14. A 3-level Bayesian mixed effects location scale model with an application to ecological momentary assessment data.

    Science.gov (United States)

    Lin, Xiaolei; Mermelstein, Robin J; Hedeker, Donald

    2018-06-15

    Ecological momentary assessment studies usually produce intensively measured longitudinal data with large numbers of observations per unit, and research interest is often centered around understanding the changes in variation of people's thoughts, emotions and behaviors. Hedeker et al developed a 2-level mixed effects location scale model that allows observed covariates as well as unobserved variables to influence both the mean and the within-subjects variance, for a 2-level data structure where observations are nested within subjects. In some ecological momentary assessment studies, subjects are measured at multiple waves, and within each wave, subjects are measured over time. Li and Hedeker extended the original 2-level model to a 3-level data structure where observations are nested within days and days are then nested within subjects, by including a random location and scale intercept at the intermediate wave level. However, the 3-level random intercept model assumes constant response change rate for both the mean and variance. To account for changes in variance across waves, as well as clustering attributable to waves, we propose a more comprehensive location scale model that allows subject heterogeneity at baseline as well as across different waves, for a 3-level data structure where observations are nested within waves and waves are then further nested within subjects. The model parameters are estimated using Markov chain Monte Carlo methods. We provide details on the Bayesian estimation approach and demonstrate how the Stan statistical software can be used to sample from the desired distributions and achieve consistent estimates. The proposed model is validated via a series of simulation studies. Data from an adolescent smoking study are analyzed to demonstrate this approach. The analyses clearly favor the proposed model and show significant subject heterogeneity at baseline as well as change over time, for both mood mean and variance. The proposed 3-level

  15. Comparing coefficients of nested nonlinear probability models

    DEFF Research Database (Denmark)

    Kohler, Ulrich; Karlson, Kristian Bernt; Holm, Anders

    2011-01-01

    In a series of recent articles, Karlson, Holm and Breen have developed a method for comparing the estimated coeffcients of two nested nonlinear probability models. This article describes this method and the user-written program khb that implements the method. The KHB-method is a general decomposi......In a series of recent articles, Karlson, Holm and Breen have developed a method for comparing the estimated coeffcients of two nested nonlinear probability models. This article describes this method and the user-written program khb that implements the method. The KHB-method is a general...... decomposition method that is unaffected by the rescaling or attenuation bias that arise in cross-model comparisons in nonlinear models. It recovers the degree to which a control variable, Z, mediates or explains the relationship between X and a latent outcome variable, Y*, underlying the nonlinear probability...

  16. Non-linear Loudspeaker Unit Modelling

    DEFF Research Database (Denmark)

    Pedersen, Bo Rohde; Agerkvist, Finn T.

    2008-01-01

    Simulations of a 6½-inch loudspeaker unit are performed and compared with a displacement measurement. The non-linear loudspeaker model is based on the major nonlinear functions and expanded with time-varying suspension behaviour and flux modulation. The results are presented with FFT plots of thr...... frequencies and different displacement levels. The model errors are discussed and analysed including a test with loudspeaker unit where the diaphragm is removed....

  17. Parameter Estimation of Nonlinear Models in Forestry.

    OpenAIRE

    Fekedulegn, Desta; Mac Siúrtáin, Máirtín Pádraig; Colbert, Jim J.

    1999-01-01

    Partial derivatives of the negative exponential, monomolecular, Mitcherlich, Gompertz, logistic, Chapman-Richards, von Bertalanffy, Weibull and the Richard’s nonlinear growth models are presented. The application of these partial derivatives in estimating the model parameters is illustrated. The parameters are estimated using the Marquardt iterative method of nonlinear regression relating top height to age of Norway spruce (Picea abies L.) from the Bowmont Norway Spruce Thinnin...

  18. Forecasting with nonlinear time series models

    DEFF Research Database (Denmark)

    Kock, Anders Bredahl; Teräsvirta, Timo

    In this paper, nonlinear models are restricted to mean nonlinear parametric models. Several such models popular in time series econo- metrics are presented and some of their properties discussed. This in- cludes two models based on universal approximators: the Kolmogorov- Gabor polynomial model...... applied to economic fore- casting problems, is briefly highlighted. A number of large published studies comparing macroeconomic forecasts obtained using different time series models are discussed, and the paper also contains a small simulation study comparing recursive and direct forecasts in a partic...... and two versions of a simple artificial neural network model. Techniques for generating multi-period forecasts from nonlinear models recursively are considered, and the direct (non-recursive) method for this purpose is mentioned as well. Forecasting with com- plex dynamic systems, albeit less frequently...

  19. Longitudinal mathematics development of students with learning disabilities and students without disabilities: a comparison of linear, quadratic, and piecewise linear mixed effects models.

    Science.gov (United States)

    Kohli, Nidhi; Sullivan, Amanda L; Sadeh, Shanna; Zopluoglu, Cengiz

    2015-04-01

    Effective instructional planning and intervening rely heavily on accurate understanding of students' growth, but relatively few researchers have examined mathematics achievement trajectories, particularly for students with special needs. We applied linear, quadratic, and piecewise linear mixed-effects models to identify the best-fitting model for mathematics development over elementary and middle school and to ascertain differences in growth trajectories of children with learning disabilities relative to their typically developing peers. The analytic sample of 2150 students was drawn from the Early Childhood Longitudinal Study - Kindergarten Cohort, a nationally representative sample of United States children who entered kindergarten in 1998. We first modeled students' mathematics growth via multiple mixed-effects models to determine the best fitting model of 9-year growth and then compared the trajectories of students with and without learning disabilities. Results indicate that the piecewise linear mixed-effects model captured best the functional form of students' mathematics trajectories. In addition, there were substantial achievement gaps between students with learning disabilities and students with no disabilities, and their trajectories differed such that students without disabilities progressed at a higher rate than their peers who had learning disabilities. The results underscore the need for further research to understand how to appropriately model students' mathematics trajectories and the need for attention to mathematics achievement gaps in policy. Copyright © 2015 Society for the Study of School Psychology. Published by Elsevier Ltd. All rights reserved.

  20. Nonlinear model predictive control theory and algorithms

    CERN Document Server

    Grüne, Lars

    2017-01-01

    This book offers readers a thorough and rigorous introduction to nonlinear model predictive control (NMPC) for discrete-time and sampled-data systems. NMPC schemes with and without stabilizing terminal constraints are detailed, and intuitive examples illustrate the performance of different NMPC variants. NMPC is interpreted as an approximation of infinite-horizon optimal control so that important properties like closed-loop stability, inverse optimality and suboptimality can be derived in a uniform manner. These results are complemented by discussions of feasibility and robustness. An introduction to nonlinear optimal control algorithms yields essential insights into how the nonlinear optimization routine—the core of any nonlinear model predictive controller—works. Accompanying software in MATLAB® and C++ (downloadable from extras.springer.com/), together with an explanatory appendix in the book itself, enables readers to perform computer experiments exploring the possibilities and limitations of NMPC. T...

  1. Topological approximation of the nonlinear Anderson model

    Science.gov (United States)

    Milovanov, Alexander V.; Iomin, Alexander

    2014-06-01

    We study the phenomena of Anderson localization in the presence of nonlinear interaction on a lattice. A class of nonlinear Schrödinger models with arbitrary power nonlinearity is analyzed. We conceive the various regimes of behavior, depending on the topology of resonance overlap in phase space, ranging from a fully developed chaos involving Lévy flights to pseudochaotic dynamics at the onset of delocalization. It is demonstrated that the quadratic nonlinearity plays a dynamically very distinguished role in that it is the only type of power nonlinearity permitting an abrupt localization-delocalization transition with unlimited spreading already at the delocalization border. We describe this localization-delocalization transition as a percolation transition on the infinite Cayley tree (Bethe lattice). It is found in the vicinity of the criticality that the spreading of the wave field is subdiffusive in the limit t →+∞. The second moment of the associated probability distribution grows with time as a power law ∝ tα, with the exponent α =1/3 exactly. Also we find for superquadratic nonlinearity that the analog pseudochaotic regime at the edge of chaos is self-controlling in that it has feedback on the topology of the structure on which the transport processes concentrate. Then the system automatically (without tuning of parameters) develops its percolation point. We classify this type of behavior in terms of self-organized criticality dynamics in Hilbert space. For subquadratic nonlinearities, the behavior is shown to be sensitive to the details of definition of the nonlinear term. A transport model is proposed based on modified nonlinearity, using the idea of "stripes" propagating the wave process to large distances. Theoretical investigations, presented here, are the basis for consistency analysis of the different localization-delocalization patterns in systems with many coupled degrees of freedom in association with the asymptotic properties of the

  2. A 6-month mixed-effect pharmacokinetic model for post-transplant intravenous anti-hepatitis B immunoglobulin prophylaxis

    Directory of Open Access Journals (Sweden)

    Han S

    2017-07-01

    Full Text Available Seunghoon Han,1,2 Gun Hyung Na,3 Dong-Goo Kim3 1Department of Pharmacology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, South Korea; 2Pharmacometrics Institute for Practical Education and Training, The Catholic University of Korea, Seocho-gu, Seoul, South Korea; 3Department of Surgery, Seoul St Mary’s Hospital, The Catholic University of Korea, Seocho-gu, Seoul, South Korea Background: Although individualized dosage regimens for anti-hepatitis B immunoglobulin (HBIG therapy have been suggested, the pharmacokinetic profile and factors influencing the basis for individualization have not been sufficiently assessed. We sought to evaluate the pharmacokinetic characteristics of anti-HBIG quantitatively during the first 6 months after liver transplantation. Methods: Identical doses of 10,000 IU HBIG were administered to adult liver transplant recipients daily during the first week, weekly thereafter until 28 postoperative days, and monthly thereafter. Blood samples were obtained at days 1, 7, 28, 84, and 168 after transplantation. Plasma HBIG titer was quantified using 4 different immunoassay methods. The titer determined by each analytical method was used for mixed-effect modeling, and the most precise results were chosen. Simulations were performed to predict the plausible immunoglobulin maintenance dose. Results: HBIG was eliminated from the body most rapidly in the immediate post-transplant period, and the elimination rate gradually decreased thereafter. In the early post-transplant period, patients with higher DNA titer tend to have lower plasma HBIG concentrations. The maintenance doses required to attain targets in 90%, 95%, and 99% of patients were ~15.3, 18.2, and 25.1 IU, respectively, multiplied by the target trough level (in IU/L. Conclusion: The variability (explained and unexplained in HBIG pharmacokinetics was relatively larger in the early post-transplant period. Dose individualization based upon

  3. Time Out-of-Home and Cognitive, Physical, and Emotional Wellbeing of Older Adults: A Longitudinal Mixed Effects Model.

    Directory of Open Access Journals (Sweden)

    Johanna Petersen

    Full Text Available Time out-of-home has been linked with numerous health outcomes, including cognitive decline, poor physical ability and low emotional state. Comprehensive characterization of this important health metric would potentially enable objective monitoring of key health outcomes. The objective of this study is to determine the relationship between time out-of-home and cognitive status, physical ability and emotional state.Participants included 85 independent older adults, age 65-96 years (M = 86.36; SD = 6.79 who lived alone, from the Intelligent Systems for Assessing Aging Changes (ISAAC and the ORCATECH Life Laboratory cohorts. Factors hypothesized to affect time out-of-home were assessed on three different temporal levels: yearly (cognitive status, loneliness, clinical walking speed, weekly (pain and mood or daily (time out-of-home, in-home walking speed, weather, and season. Subject characteristics including age, race, and gender were assessed at baseline. Total daily time out-of-home in hours was assessed objectively and unobtrusively for up to one year using an in-home activity sensor platform. A longitudinal tobit mixed effects regression model was used to relate daily time out-of-home to cognitive status, physical ability and emotional state. More hours spend outside the home was associated with better cognitive function as assessed using the Clinical Dementia Rating (CDR Scale, where higher scores indicate lower cognitive function (βCDR = -1.69, p<0.001. More hours outside the home was also associated with superior physical ability (βPain = -0.123, p<0.001 and improved emotional state (βLonely = -0.046, p<0.001; βLow mood = -0.520, p<0.001. Weather, season, and weekday also affected the daily time out-of-home.These results suggest that objective longitudinal monitoring of time out-of-home may enable unobtrusive assessment of cognitive, physical and emotional state. In addition, these results indicate that the factors affecting out

  4. On the nonlinear modeling of ring oscillators

    KAUST Repository

    Elwakil, Ahmed S.

    2009-06-01

    We develop higher-order nonlinear models of three-stage and five-stage ring oscillators based on a novel inverter model. The oscillation condition and oscillation frequency are derived and compared to classical linear model analysis. Two important special cases for five-stage ring oscillators are also studied. Numerical simulations are shown. © 2009 World Scientific Publishing Company.

  5. Nonlinear control of the Salnikov model reaction

    DEFF Research Database (Denmark)

    Recke, Bodil; Jørgensen, Sten Bay

    1999-01-01

    This paper explores different nonlinear control schemes, applied to a simple model reaction. The model is the Salnikov model, consisting of two ordinary differential equations. The control strategies investigated are I/O-linearisation, Exact linearisation, exact linearisation combined with LQR...

  6. On the nonlinear modeling of ring oscillators

    KAUST Repository

    Elwakil, Ahmed S.; Salama, Khaled N.

    2009-01-01

    We develop higher-order nonlinear models of three-stage and five-stage ring oscillators based on a novel inverter model. The oscillation condition and oscillation frequency are derived and compared to classical linear model analysis. Two important special cases for five-stage ring oscillators are also studied. Numerical simulations are shown. © 2009 World Scientific Publishing Company.

  7. Correlations and Non-Linear Probability Models

    DEFF Research Database (Denmark)

    Breen, Richard; Holm, Anders; Karlson, Kristian Bernt

    2014-01-01

    the dependent variable of the latent variable model and its predictor variables. We show how this correlation can be derived from the parameters of non-linear probability models, develop tests for the statistical significance of the derived correlation, and illustrate its usefulness in two applications. Under......Although the parameters of logit and probit and other non-linear probability models are often explained and interpreted in relation to the regression coefficients of an underlying linear latent variable model, we argue that they may also be usefully interpreted in terms of the correlations between...... certain circumstances, which we explain, the derived correlation provides a way of overcoming the problems inherent in cross-sample comparisons of the parameters of non-linear probability models....

  8. Evaluation of nonlinearity and validity of nonlinear modeling for complex time series.

    Science.gov (United States)

    Suzuki, Tomoya; Ikeguchi, Tohru; Suzuki, Masuo

    2007-10-01

    Even if an original time series exhibits nonlinearity, it is not always effective to approximate the time series by a nonlinear model because such nonlinear models have high complexity from the viewpoint of information criteria. Therefore, we propose two measures to evaluate both the nonlinearity of a time series and validity of nonlinear modeling applied to it by nonlinear predictability and information criteria. Through numerical simulations, we confirm that the proposed measures effectively detect the nonlinearity of an observed time series and evaluate the validity of the nonlinear model. The measures are also robust against observational noises. We also analyze some real time series: the difference of the number of chickenpox and measles patients, the number of sunspots, five Japanese vowels, and the chaotic laser. We can confirm that the nonlinear model is effective for the Japanese vowel /a/, the difference of the number of measles patients, and the chaotic laser.

  9. Nonlinear Model Reduction for RTCVD

    National Research Council Canada - National Science Library

    Newman, Andrew J; Krishnaprasad, P. S

    1998-01-01

    ...) for semiconductor manufacturing. They focus on model reduction for the ordinary differential equation model describing heat transfer to, from, and within a semiconductor wafer in the RTCVD chamber...

  10. Nonlinear finite element modeling of corrugated board

    Science.gov (United States)

    A. C. Gilchrist; J. C. Suhling; T. J. Urbanik

    1999-01-01

    In this research, an investigation on the mechanical behavior of corrugated board has been performed using finite element analysis. Numerical finite element models for corrugated board geometries have been created and executed. Both geometric (large deformation) and material nonlinearities were included in the models. The analyses were performed using the commercial...

  11. Nonlinear Modelling of Low Frequency Loudspeakers

    DEFF Research Database (Denmark)

    Olsen, Erling Sandermann

    1997-01-01

    In the Danish LoDist project on distortion from dynamic low frequency loudspeakers a detailed nonlinear model of loudspeakers has been developed. The model has been implemented in a PC program so that it can be used to create signals for listening tests and analysis. Also, different methods...

  12. Nonlinear Modelling of Low Frequency Loudspeakers

    DEFF Research Database (Denmark)

    Olsen, Erling Sandermann

    1997-01-01

    In the Danish LoDist project on distortion from dynamic low-frequency loudspeakers, a detailed nonlinear model of loudspeakers has been developed. The model has been implemented in a PC program so that it can be used to create signals for listening tests and analysis. Also, different methods...

  13. Modeling vector nonlinear time series using POLYMARS

    NARCIS (Netherlands)

    de Gooijer, J.G.; Ray, B.K.

    2003-01-01

    A modified multivariate adaptive regression splines method for modeling vector nonlinear time series is investigated. The method results in models that can capture certain types of vector self-exciting threshold autoregressive behavior, as well as provide good predictions for more general vector

  14. Advantage of make-to-stock strategy based on linear mixed-effect model: a comparison with regression, autoregressive, times series, and exponential smoothing models

    Directory of Open Access Journals (Sweden)

    Yu-Pin Liao

    2017-11-01

    Full Text Available In the past few decades, demand forecasting has become relatively difficult due to rapid changes in the global environment. This research illustrates the use of the make-to-stock (MTS production strategy in order to explain how forecasting plays an essential role in business management. The linear mixed-effect (LME model has been extensively developed and is widely applied in various fields. However, no study has used the LME model for business forecasting. We suggest that the LME model be used as a tool for prediction and to overcome environment complexity. The data analysis is based on real data in an international display company, where the company needs accurate demand forecasting before adopting a MTS strategy. The forecasting result from the LME model is compared to the commonly used approaches, including the regression model, autoregressive model, times series model, and exponential smoothing model, with the results revealing that prediction performance provided by the LME model is more stable than using the other methods. Furthermore, product types in the data are regarded as a random effect in the LME model, hence demands of all types can be predicted simultaneously using a single LME model. However, some approaches require splitting the data into different type categories, and then predicting the type demand by establishing a model for each type. This feature also demonstrates the practicability of the LME model in real business operations.

  15. Nonlinear friction model for servo press simulation

    Science.gov (United States)

    Ma, Ninshu; Sugitomo, Nobuhiko; Kyuno, Takunori; Tamura, Shintaro; Naka, Tetsuo

    2013-12-01

    The friction coefficient was measured under an idealized condition for a pulse servo motion. The measured friction coefficient and its changing with both sliding distance and a pulse motion showed that the friction resistance can be reduced due to the re-lubrication during unloading process of the pulse servo motion. Based on the measured friction coefficient and its changes with sliding distance and re-lubrication of oil, a nonlinear friction model was developed. Using the newly developed the nonlinear friction model, a deep draw simulation was performed and the formability was evaluated. The results were compared with experimental ones and the effectiveness was verified.

  16. Finite element model for nonlinear shells of revolution

    International Nuclear Information System (INIS)

    Cook, W.A.

    1979-01-01

    Nuclear material shipping containers have shells of revolution as basic structural components. Analytically modeling the response of these containers to severe accident impact conditions requires a nonlinear shell-of-revolution model that accounts for both geometric and material nonlinearities. Existing models are limited to large displacements, small rotations, and nonlinear materials. The paper presents a finite element model for a nonlinear shell of revolution that will account for large displacements, large strains, large rotations, and nonlinear materials

  17. Modeling of Volatility with Non-linear Time Series Model

    OpenAIRE

    Kim Song Yon; Kim Mun Chol

    2013-01-01

    In this paper, non-linear time series models are used to describe volatility in financial time series data. To describe volatility, two of the non-linear time series are combined into form TAR (Threshold Auto-Regressive Model) with AARCH (Asymmetric Auto-Regressive Conditional Heteroskedasticity) error term and its parameter estimation is studied.

  18. On nonlinear reduced order modeling

    International Nuclear Information System (INIS)

    Abdel-Khalik, Hany S.

    2011-01-01

    When applied to a model that receives n input parameters and predicts m output responses, a reduced order model estimates the variations in the m outputs of the original model resulting from variations in its n inputs. While direct execution of the forward model could provide these variations, reduced order modeling plays an indispensable role for most real-world complex models. This follows because the solutions of complex models are expensive in terms of required computational overhead, thus rendering their repeated execution computationally infeasible. To overcome this problem, reduced order modeling determines a relationship (often referred to as a surrogate model) between the input and output variations that is much cheaper to evaluate than the original model. While it is desirable to seek highly accurate surrogates, the computational overhead becomes quickly intractable especially for high dimensional model, n ≫ 10. In this manuscript, we demonstrate a novel reduced order modeling method for building a surrogate model that employs only 'local first-order' derivatives and a new tensor-free expansion to efficiently identify all the important features of the original model to reach a predetermined level of accuracy. This is achieved via a hybrid approach in which local first-order derivatives (i.e., gradient) of a pseudo response (a pseudo response represents a random linear combination of original model’s responses) are randomly sampled utilizing a tensor-free expansion around some reference point, with the resulting gradient information aggregated in a subspace (denoted by the active subspace) of dimension much less than the dimension of the input parameters space. The active subspace is then sampled employing the state-of-the-art techniques for global sampling methods. The proposed method hybridizes the use of global sampling methods for uncertainty quantification and local variational methods for sensitivity analysis. In a similar manner to

  19. Perturbation analysis of nonlinear matrix population models

    Directory of Open Access Journals (Sweden)

    Hal Caswell

    2008-03-01

    Full Text Available Perturbation analysis examines the response of a model to changes in its parameters. It is commonly applied to population growth rates calculated from linear models, but there has been no general approach to the analysis of nonlinear models. Nonlinearities in demographic models may arise due to density-dependence, frequency-dependence (in 2-sex models, feedback through the environment or the economy, and recruitment subsidy due to immigration, or from the scaling inherent in calculations of proportional population structure. This paper uses matrix calculus to derive the sensitivity and elasticity of equilibria, cycles, ratios (e.g. dependency ratios, age averages and variances, temporal averages and variances, life expectancies, and population growth rates, for both age-classified and stage-classified models. Examples are presented, applying the results to both human and non-human populations.

  20. Nonlinear distortion in wireless systems modeling and simulation with Matlab

    CERN Document Server

    Gharaibeh, Khaled M

    2011-01-01

    This book covers the principles of modeling and simulation of nonlinear distortion in wireless communication systems with MATLAB simulations and techniques In this book, the author describes the principles of modeling and simulation of nonlinear distortion in single and multichannel wireless communication systems using both deterministic and stochastic signals. Models and simulation methods of nonlinear amplifiers explain in detail how to analyze and evaluate the performance of data communication links under nonlinear amplification. The book addresses the analysis of nonlinear systems

  1. Nonlinear optical model for strip plasmonic waveguides

    DEFF Research Database (Denmark)

    Lysenko, Oleg; Bache, Morten; Lavrinenko, Andrei

    2016-01-01

    This paper presents a theoretical model of nonlinear optical properties for strip plasmonic waveguides. The particular waveguides geometry that we investigate contains a gold core, adhesion layers, and silicon dioxide cladding. It is shown that the third-order susceptibility of the gold core...... significantly depends on the layer thickness and has the dominant contribution to the effective third-order susceptibility of the long-range plasmon polariton mode. This results in two nonlinear optical effects in plasmonic waveguides, which we experimentally observed and reported in [Opt. Lett. 41, 317 (2016...... approaches. (C) 2016 Optical Society of America...

  2. Survival analysis of clinical mastitis data using a nested frailty Cox model fit as a mixed-effects Poisson model.

    Science.gov (United States)

    Elghafghuf, Adel; Dufour, Simon; Reyher, Kristen; Dohoo, Ian; Stryhn, Henrik

    2014-12-01

    Mastitis is a complex disease affecting dairy cows and is considered to be the most costly disease of dairy herds. The hazard of mastitis is a function of many factors, both managerial and environmental, making its control a difficult issue to milk producers. Observational studies of clinical mastitis (CM) often generate datasets with a number of characteristics which influence the analysis of those data: the outcome of interest may be the time to occurrence of a case of mastitis, predictors may change over time (time-dependent predictors), the effects of factors may change over time (time-dependent effects), there are usually multiple hierarchical levels, and datasets may be very large. Analysis of such data often requires expansion of the data into the counting-process format - leading to larger datasets - thus complicating the analysis and requiring excessive computing time. In this study, a nested frailty Cox model with time-dependent predictors and effects was applied to Canadian Bovine Mastitis Research Network data in which 10,831 lactations of 8035 cows from 69 herds were followed through lactation until the first occurrence of CM. The model was fit to the data as a Poisson model with nested normally distributed random effects at the cow and herd levels. Risk factors associated with the hazard of CM during the lactation were identified, such as parity, calving season, herd somatic cell score, pasture access, fore-stripping, and proportion of treated cases of CM in a herd. The analysis showed that most of the predictors had a strong effect early in lactation and also demonstrated substantial variation in the baseline hazard among cows and between herds. A small simulation study for a setting similar to the real data was conducted to evaluate the Poisson maximum likelihood estimation approach with both Gaussian quadrature method and Laplace approximation. Further, the performance of the two methods was compared with the performance of a widely used estimation

  3. Nonlinear GARCH model and 1 / f noise

    Science.gov (United States)

    Kononovicius, A.; Ruseckas, J.

    2015-06-01

    Auto-regressive conditionally heteroskedastic (ARCH) family models are still used, by practitioners in business and economic policy making, as a conditional volatility forecasting models. Furthermore ARCH models still are attracting an interest of the researchers. In this contribution we consider the well known GARCH(1,1) process and its nonlinear modifications, reminiscent of NGARCH model. We investigate the possibility to reproduce power law statistics, probability density function and power spectral density, using ARCH family models. For this purpose we derive stochastic differential equations from the GARCH processes in consideration. We find the obtained equations to be similar to a general class of stochastic differential equations known to reproduce power law statistics. We show that linear GARCH(1,1) process has power law distribution, but its power spectral density is Brownian noise-like. However, the nonlinear modifications exhibit both power law distribution and power spectral density of the 1 /fβ form, including 1 / f noise.

  4. Nonlinear Dynamic Models in Advanced Life Support

    Science.gov (United States)

    Jones, Harry

    2002-01-01

    To facilitate analysis, ALS systems are often assumed to be linear and time invariant, but they usually have important nonlinear and dynamic aspects. Nonlinear dynamic behavior can be caused by time varying inputs, changes in system parameters, nonlinear system functions, closed loop feedback delays, and limits on buffer storage or processing rates. Dynamic models are usually cataloged according to the number of state variables. The simplest dynamic models are linear, using only integration, multiplication, addition, and subtraction of the state variables. A general linear model with only two state variables can produce all the possible dynamic behavior of linear systems with many state variables, including stability, oscillation, or exponential growth and decay. Linear systems can be described using mathematical analysis. Nonlinear dynamics can be fully explored only by computer simulations of models. Unexpected behavior is produced by simple models having only two or three state variables with simple mathematical relations between them. Closed loop feedback delays are a major source of system instability. Exceeding limits on buffer storage or processing rates forces systems to change operating mode. Different equilibrium points may be reached from different initial conditions. Instead of one stable equilibrium point, the system may have several equilibrium points, oscillate at different frequencies, or even behave chaotically, depending on the system inputs and initial conditions. The frequency spectrum of an output oscillation may contain harmonics and the sums and differences of input frequencies, but it may also contain a stable limit cycle oscillation not related to input frequencies. We must investigate the nonlinear dynamic aspects of advanced life support systems to understand and counter undesirable behavior.

  5. Analysis of nonlinear systems using ARMA [autoregressive moving average] models

    International Nuclear Information System (INIS)

    Hunter, N.F. Jr.

    1990-01-01

    While many vibration systems exhibit primarily linear behavior, a significant percentage of the systems encountered in vibration and model testing are mildly to severely nonlinear. Analysis methods for such nonlinear systems are not yet well developed and the response of such systems is not accurately predicted by linear models. Nonlinear ARMA (autoregressive moving average) models are one method for the analysis and response prediction of nonlinear vibratory systems. In this paper we review the background of linear and nonlinear ARMA models, and illustrate the application of these models to nonlinear vibration systems. We conclude by summarizing the advantages and disadvantages of ARMA models and emphasizing prospects for future development. 14 refs., 11 figs

  6. A nonlinear model for AC induced corrosion

    Directory of Open Access Journals (Sweden)

    N. Ida

    2012-09-01

    Full Text Available The modeling of corrosion poses particular difficulties. The understanding of corrosion as an electrochemical process has led to simple capacitive-resistive models that take into account the resistance of the electrolytic cell and the capacitive effect of the surface potential at the interface between conductors and the electrolyte. In some models nonlinear conduction effects have been added to account for more complex observed behavior. While these models are sufficient to describe the behavior in systems with cathodic protection, the behavior in the presence of induced AC currents from power lines and from RF sources cannot be accounted for and are insufficient to describe the effects observed in the field. Field observations have shown that a rectifying effect exists that affects the cathodic protection potential and this effect is responsible for corrosion in the presence of AC currents. The rectifying effects of the metal-corrosion interface are totally missing from current models. This work proposes a nonlinear model based on finite element analysis that takes into account the nonlinear behavior of the metal-oxide interface and promises to improve modeling by including the rectification effects at the interface.

  7. Research on nonlinear stochastic dynamical price model

    International Nuclear Information System (INIS)

    Li Jiaorui; Xu Wei; Xie Wenxian; Ren Zhengzheng

    2008-01-01

    In consideration of many uncertain factors existing in economic system, nonlinear stochastic dynamical price model which is subjected to Gaussian white noise excitation is proposed based on deterministic model. One-dimensional averaged Ito stochastic differential equation for the model is derived by using the stochastic averaging method, and applied to investigate the stability of the trivial solution and the first-passage failure of the stochastic price model. The stochastic price model and the methods presented in this paper are verified by numerical studies

  8. Simplified Model of Nonlinear Landau Damping

    International Nuclear Information System (INIS)

    Yampolsky, N.A.; Fisch, N.J.

    2009-01-01

    The nonlinear interaction of a plasma wave with resonant electrons results in a plateau in the electron distribution function close to the phase velocity of the plasma wave. As a result, Landau damping of the plasma wave vanishes and the resonant frequency of the plasma wave downshifts. However, this simple picture is invalid when the external driving force changes the plasma wave fast enough so that the plateau cannot be fully developed. A new model to describe amplification of the plasma wave including the saturation of Landau damping and the nonlinear frequency shift is proposed. The proposed model takes into account the change of the plasma wave amplitude and describes saturation of the Landau damping rate in terms of a single fluid equation, which simplifies the description of the inherently kinetic nature of Landau damping. A proposed fluid model, incorporating these simplifications, is verified numerically using a kinetic Vlasov code.

  9. Nonlinear behaviour of cantilevered carbon nanotube resonators based on a new nonlinear electrostatic load model

    Science.gov (United States)

    Farokhi, Hamed; Païdoussis, Michael P.; Misra, Arun K.

    2018-04-01

    The present study examines the nonlinear behaviour of a cantilevered carbon nanotube (CNT) resonator and its mass detection sensitivity, employing a new nonlinear electrostatic load model. More specifically, a 3D finite element model is developed in order to obtain the electrostatic load distribution on cantilevered CNT resonators. A new nonlinear electrostatic load model is then proposed accounting for the end effects due to finite length. Additionally, a new nonlinear size-dependent continuum model is developed for the cantilevered CNT resonator, employing the modified couple stress theory (to account for size-effects) together with the Kelvin-Voigt model (to account for nonlinear damping); the size-dependent model takes into account all sources of nonlinearity, i.e. geometrical and inertial nonlinearities as well as nonlinearities associated with damping, small-scale, and electrostatic load. The nonlinear equation of motion of the cantilevered CNT resonator is obtained based on the new models developed for the CNT resonator and the electrostatic load. The Galerkin method is then applied to the nonlinear equation of motion, resulting in a set of nonlinear ordinary differential equations, consisting of geometrical, inertial, electrical, damping, and size-dependent nonlinear terms. This high-dimensional nonlinear discretized model is solved numerically utilizing the pseudo-arclength continuation technique. The nonlinear static and dynamic responses of the system are examined for various cases, investigating the effect of DC and AC voltages, length-scale parameter, nonlinear damping, and electrostatic load. Moreover, the mass detection sensitivity of the system is examined for possible application of the CNT resonator as a nanosensor.

  10. Prevention of chronic PTSD with early cognitive behavioral therapy. A meta-analysis using mixed-effects modeling.

    Science.gov (United States)

    Kliem, Sören; Kröger, Christoph

    2013-11-01

    Post-traumatic stress disorder (PTSD) is of great interest to public health, due to the high burden it places on both the individual and society. We meta-analyzed randomized-controlled trials to examine the effectiveness of early trauma-focused cognitive-behavioral treatment (TFCBT) for preventing chronic PTSD. Systematic bibliographic research was undertaken to find relevant literature from on-line databases (Pubmed, PsycINFO, Psyndex, Medline). Using a mixed-effect approach, we calculated effect sizes (ES) for the PTSD diagnoses (main outcome) as well as PTSD and depressive symptoms (secondary outcomes), respectively. Calculations of ES from pre-intervention to first follow-up assessment were based on 10 studies. A moderate effect (ES = 0.54) was found for the main outcome, whereas ES for secondary outcomes were predominantly small (ES = 0.27-0.45). The ES for the main outcome decreased to small (ES = 0.34) from first follow-up to long-term follow-up assessment. The mean dropout rate was 16.7% pre- to post-treatment. There was evidence for the impact of moderators on different outcomes (e.g., the number of sessions on PTSD symptoms). Future studies should include survivors of other trauma types (e.g., burn injuries) rather than predominantly survivors of accidents and physical assault, and should compare early TFCBT with other interventions that previously demonstrated effectiveness. Copyright © 2013 Elsevier Ltd. All rights reserved.

  11. Application of Linear Mixed-Effects Models in Human Neuroscience Research: A Comparison with Pearson Correlation in Two Auditory Electrophysiology Studies.

    Science.gov (United States)

    Koerner, Tess K; Zhang, Yang

    2017-02-27

    Neurophysiological studies are often designed to examine relationships between measures from different testing conditions, time points, or analysis techniques within the same group of participants. Appropriate statistical techniques that can take into account repeated measures and multivariate predictor variables are integral and essential to successful data analysis and interpretation. This work implements and compares conventional Pearson correlations and linear mixed-effects (LME) regression models using data from two recently published auditory electrophysiology studies. For the specific research questions in both studies, the Pearson correlation test is inappropriate for determining strengths between the behavioral responses for speech-in-noise recognition and the multiple neurophysiological measures as the neural responses across listening conditions were simply treated as independent measures. In contrast, the LME models allow a systematic approach to incorporate both fixed-effect and random-effect terms to deal with the categorical grouping factor of listening conditions, between-subject baseline differences in the multiple measures, and the correlational structure among the predictor variables. Together, the comparative data demonstrate the advantages as well as the necessity to apply mixed-effects models to properly account for the built-in relationships among the multiple predictor variables, which has important implications for proper statistical modeling and interpretation of human behavior in terms of neural correlates and biomarkers.

  12. Thermoviscous Model Equations in Nonlinear Acoustics

    DEFF Research Database (Denmark)

    Rasmussen, Anders Rønne

    Four nonlinear acoustical wave equations that apply to both perfect gasses and arbitrary fluids with a quadratic equation of state are studied. Shock and rarefaction wave solutions to the equations are studied. In order to assess the accuracy of the wave equations, their solutions are compared...... to solutions of the basic equations from which the wave equations are derived. A straightforward weakly nonlinear equation is the most accurate for shock modeling. A higher order wave equation is the most accurate for modeling of smooth disturbances. Investigations of the linear stability properties...... of solutions to the wave equations, reveal that the solutions may become unstable. Such instabilities are not found in the basic equations. Interacting shocks and standing shocks are investigated....

  13. Nonlinear modelling of polymer electrolyte membrane fuel cell stack using nonlinear cancellation technique

    Energy Technology Data Exchange (ETDEWEB)

    Barus, R. P. P., E-mail: rismawan.ppb@gmail.com [Engineering Physics, Faculty of Industrial Technology, Institut Teknologi Bandung, Jalan Ganesa 10 Bandung and Centre for Material and Technical Product, Jalan Sangkuriang No. 14 Bandung (Indonesia); Tjokronegoro, H. A.; Leksono, E. [Engineering Physics, Faculty of Industrial Technology, Institut Teknologi Bandung, Jalan Ganesa 10 Bandung (Indonesia); Ismunandar [Chemistry Study, Faculty of Mathematics and Science, Institut Teknologi Bandung, Jalan Ganesa 10 Bandung (Indonesia)

    2014-09-25

    Fuel cells are promising new energy conversion devices that are friendly to the environment. A set of control systems are required in order to operate a fuel cell based power plant system optimally. For the purpose of control system design, an accurate fuel cell stack model in describing the dynamics of the real system is needed. Currently, linear model are widely used for fuel cell stack control purposes, but it has limitations in narrow operation range. While nonlinear models lead to nonlinear control implemnetation whos more complex and hard computing. In this research, nonlinear cancellation technique will be used to transform a nonlinear model into a linear form while maintaining the nonlinear characteristics. The transformation is done by replacing the input of the original model by a certain virtual input that has nonlinear relationship with the original input. Then the equality of the two models is tested by running a series of simulation. Input variation of H2, O2 and H2O as well as disturbance input I (current load) are studied by simulation. The error of comparison between the proposed model and the original nonlinear model are less than 1 %. Thus we can conclude that nonlinear cancellation technique can be used to represent fuel cell nonlinear model in a simple linear form while maintaining the nonlinear characteristics and therefore retain the wide operation range.

  14. Nonlinear modelling of polymer electrolyte membrane fuel cell stack using nonlinear cancellation technique

    International Nuclear Information System (INIS)

    Barus, R. P. P.; Tjokronegoro, H. A.; Leksono, E.; Ismunandar

    2014-01-01

    Fuel cells are promising new energy conversion devices that are friendly to the environment. A set of control systems are required in order to operate a fuel cell based power plant system optimally. For the purpose of control system design, an accurate fuel cell stack model in describing the dynamics of the real system is needed. Currently, linear model are widely used for fuel cell stack control purposes, but it has limitations in narrow operation range. While nonlinear models lead to nonlinear control implemnetation whos more complex and hard computing. In this research, nonlinear cancellation technique will be used to transform a nonlinear model into a linear form while maintaining the nonlinear characteristics. The transformation is done by replacing the input of the original model by a certain virtual input that has nonlinear relationship with the original input. Then the equality of the two models is tested by running a series of simulation. Input variation of H2, O2 and H2O as well as disturbance input I (current load) are studied by simulation. The error of comparison between the proposed model and the original nonlinear model are less than 1 %. Thus we can conclude that nonlinear cancellation technique can be used to represent fuel cell nonlinear model in a simple linear form while maintaining the nonlinear characteristics and therefore retain the wide operation range

  15. Model reduction of systems with localized nonlinearities.

    Energy Technology Data Exchange (ETDEWEB)

    Segalman, Daniel Joseph

    2006-03-01

    An LDRD funded approach to development of reduced order models for systems with local nonlinearities is presented. This method is particularly useful for problems of structural dynamics, but has potential application in other fields. The key elements of this approach are (1) employment of eigen modes of a reference linear system, (2) incorporation of basis functions with an appropriate discontinuity at the location of the nonlinearity. Galerkin solution using the above combination of basis functions appears to capture the dynamics of the system with a small basis set. For problems involving small amplitude dynamics, the addition of discontinuous (joint) modes appears to capture the nonlinear mechanics correctly while preserving the modal form of the predictions. For problems involving large amplitude dynamics of realistic joint models (macro-slip), the use of appropriate joint modes along with sufficient basis eigen modes to capture the frequencies of the system greatly enhances convergence, though the modal nature the result is lost. Also observed is that when joint modes are used in conjunction with a small number of elastic eigen modes in problems of macro-slip of realistic joint models, the resulting predictions are very similar to those of the full solution when seen through a low pass filter. This has significance both in terms of greatly reducing the number of degrees of freedom of the problem and in terms of facilitating the use of much larger time steps.

  16. Nonlinear Inertia Classification Model and Application

    Directory of Open Access Journals (Sweden)

    Mei Wang

    2014-01-01

    Full Text Available Classification model of support vector machine (SVM overcomes the problem of a big number of samples. But the kernel parameter and the punishment factor have great influence on the quality of SVM model. Particle swarm optimization (PSO is an evolutionary search algorithm based on the swarm intelligence, which is suitable for parameter optimization. Accordingly, a nonlinear inertia convergence classification model (NICCM is proposed after the nonlinear inertia convergence (NICPSO is developed in this paper. The velocity of NICPSO is firstly defined as the weighted velocity of the inertia PSO, and the inertia factor is selected to be a nonlinear function. NICPSO is used to optimize the kernel parameter and a punishment factor of SVM. Then, NICCM classifier is trained by using the optical punishment factor and the optical kernel parameter that comes from the optimal particle. Finally, NICCM is applied to the classification of the normal state and fault states of online power cable. It is experimentally proved that the iteration number for the proposed NICPSO to reach the optimal position decreases from 15 to 5 compared with PSO; the training duration is decreased by 0.0052 s and the recognition precision is increased by 4.12% compared with SVM.

  17. NONLINEAR MODEL PREDICTIVE CONTROL OF CHEMICAL PROCESSES

    Directory of Open Access Journals (Sweden)

    SILVA R. G.

    1999-01-01

    Full Text Available A new algorithm for model predictive control is presented. The algorithm utilizes a simultaneous solution and optimization strategy to solve the model's differential equations. The equations are discretized by equidistant collocation, and along with the algebraic model equations are included as constraints in a nonlinear programming (NLP problem. This algorithm is compared with the algorithm that uses orthogonal collocation on finite elements. The equidistant collocation algorithm results in simpler equations, providing a decrease in computation time for the control moves. Simulation results are presented and show a satisfactory performance of this algorithm.

  18. Nonlinear chaotic model for predicting storm surges

    Directory of Open Access Journals (Sweden)

    M. Siek

    2010-09-01

    Full Text Available This paper addresses the use of the methods of nonlinear dynamics and chaos theory for building a predictive chaotic model from time series. The chaotic model predictions are made by the adaptive local models based on the dynamical neighbors found in the reconstructed phase space of the observables. We implemented the univariate and multivariate chaotic models with direct and multi-steps prediction techniques and optimized these models using an exhaustive search method. The built models were tested for predicting storm surge dynamics for different stormy conditions in the North Sea, and are compared to neural network models. The results show that the chaotic models can generally provide reliable and accurate short-term storm surge predictions.

  19. Spatiotemporal drought forecasting using nonlinear models

    Science.gov (United States)

    Vasiliades, Lampros; Loukas, Athanasios

    2010-05-01

    Spatiotemporal data mining is the extraction of unknown and implicit knowledge, structures, spatiotemporal relationships, or patterns not explicitly stored in spatiotemporal databases. As one of data mining techniques, forecasting is widely used to predict the unknown future based upon the patterns hidden in the current and past data. In order to achieve spatiotemporal forecasting, some mature analysis tools, e.g., time series and spatial statistics are extended to the spatial dimension and the temporal dimension, respectively. Drought forecasting plays an important role in the planning and management of natural resources and water resource systems in a river basin. Early and timelines forecasting of a drought event can help to take proactive measures and set out drought mitigation strategies to alleviate the impacts of drought. Despite the widespread application of nonlinear mathematical models, comparative studies on spatiotemporal drought forecasting using different models are still a huge task for modellers. This study uses a promising approach, the Gamma Test (GT), to select the input variables and the training data length, so that the trial and error workload could be greatly reduced. The GT enables to quickly evaluate and estimate the best mean squared error that can be achieved by a smooth model on any unseen data for a given selection of inputs, prior to model construction. The GT is applied to forecast droughts using monthly Standardized Precipitation Index (SPI) timeseries at multiple timescales in several precipitation stations at Pinios river basin in Thessaly region, Greece. Several nonlinear models have been developed efficiently, with the aid of the GT, for 1-month up to 12-month ahead forecasting. Several temporal and spatial statistical indices were considered for the performance evaluation of the models. The predicted results show reasonably good agreement with the actual data for short lead times, whereas the forecasting accuracy decreases with

  20. Using Swiss Webster mice to model Fetal Alcohol Spectrum Disorders (FASD): An analysis of multilevel time-to-event data through mixed-effects Cox proportional hazards models.

    Science.gov (United States)

    Chi, Peter; Aras, Radha; Martin, Katie; Favero, Carlita

    2016-05-15

    Fetal Alcohol Spectrum Disorders (FASD) collectively describes the constellation of effects resulting from human alcohol consumption during pregnancy. Even with public awareness, the incidence of FASD is estimated to be upwards of 5% in the general population and is becoming a global health problem. The physical, cognitive, and behavioral impairments of FASD are recapitulated in animal models. Recently rodent models utilizing voluntary drinking paradigms have been developed that accurately reflect moderate consumption, which makes up the majority of FASD cases. The range in severity of FASD characteristics reflects the frequency, dose, developmental timing, and individual susceptibility to alcohol exposure. As most rodent models of FASD use C57BL/6 mice, there is a need to expand the stocks of mice studied in order to more fully understand the complex neurobiology of this disorder. To that end, we allowed pregnant Swiss Webster mice to voluntarily drink ethanol via the drinking in the dark (DID) paradigm throughout their gestation period. Ethanol exposure did not alter gestational outcomes as determined by no significant differences in maternal weight gain, maternal liquid consumption, litter size, or pup weight at birth or weaning. Despite seemingly normal gestation, ethanol-exposed offspring exhibit significantly altered timing to achieve developmental milestones (surface righting, cliff aversion, and open field traversal), as analyzed through mixed-effects Cox proportional hazards models. These results confirm Swiss Webster mice as a viable option to study the incidence and causes of ethanol-induced neurobehavioral alterations during development. Future studies in our laboratory will investigate the brain regions and molecules responsible for these behavioral changes. Copyright © 2016. Published by Elsevier B.V.

  1. Linear mixed-effects models to describe length-weight relationships for yellow croaker (Larimichthys Polyactis) along the north coast of China.

    Science.gov (United States)

    Ma, Qiuyun; Jiao, Yan; Ren, Yiping

    2017-01-01

    In this study, length-weight relationships and relative condition factors were analyzed for Yellow Croaker (Larimichthys polyactis) along the north coast of China. Data covered six regions from north to south: Yellow River Estuary, Coastal Waters of Northern Shandong, Jiaozhou Bay, Coastal Waters of Qingdao, Haizhou Bay, and South Yellow Sea. In total 3,275 individuals were collected during six years (2008, 2011-2015). One generalized linear model, two simply linear models and nine linear mixed effect models that applied the effects from regions and/or years to coefficient a and/or the exponent b were studied and compared. Among these twelve models, the linear mixed effect model with random effects from both regions and years fit the data best, with lowest Akaike information criterion value and mean absolute error. In this model, the estimated a was 0.0192, with 95% confidence interval 0.0178~0.0308, and the estimated exponent b was 2.917 with 95% confidence interval 2.731~2.945. Estimates for a and b with the random effects in intercept and coefficient from Region and Year, ranged from 0.013 to 0.023 and from 2.835 to 3.017, respectively. Both regions and years had effects on parameters a and b, while the effects from years were shown to be much larger than those from regions. Except for Coastal Waters of Northern Shandong, a decreased from north to south. Condition factors relative to reference years of 1960, 1986, 2005, 2007, 2008~2009 and 2010 revealed that the body shape of Yellow Croaker became thinner in recent years. Furthermore relative condition factors varied among months, years, regions and length. The values of a and relative condition factors decreased, when the environmental pollution became worse, therefore, length-weight relationships could be an indicator for the environment quality. Results from this study provided basic description of current condition of Yellow Croaker along the north coast of China.

  2. Nonlinear mixed effect models for predicting relationships between total height and diameter of oriental beech trees in Kestel, Turkey

    Directory of Open Access Journals (Sweden)

    Ilker Ercanli

    2015-01-01

    Full Text Available Modelos estadísticos no lineales de efectos mixtos se utilizaron para predecir las relaciones entre la altura total y el diámetro a la altura del pecho (DAP en rodales de árboles de haya oriental (Fagus orientalis Lipsky en Kestel, Bursa, al noroeste de Turquía. Un total de 124 parcelas de muestreo se seleccionaron para representar la calidad de sitio, edad y densidad de rodal. Nueve modelos no lineales generalizados de altura-diámetro se ajustaron y evaluaron con base en el criterio de información de Akaike, el criterio de información bayesiana de Schwarz, la raíz del cuadrado medio del error (RMSE por sus siglas en inglés, el sesgo absoluto y el coeficiente de determinación ajustado (R2adj. El modelo no lineal de Schnute se seleccionó como el mejor modelo predictivo. El modelo de altura-diámetro basado en el enfoque del modelo no lineal de efectos mixtos representó 90.6 % de la varianza total en las relaciones de altura-diámetro y los valores de RMSE de 1.48 m. Varios escenarios que difieren en el diseño de muestreo y el tamaño de los árboles submuestra, seleccionados del conjunto de datos de validación, revelaron que cuatro árboles submuestra seleccionados al azar produjeron los mejores resultados predictivos (reducción de 43.3 % de la suma de errores cuadrados, 98.4 % del sesgo absoluto y 36.9 % de la RMSE en relación con las predicciones de los efectos fijos.

  3. Nonlinear mixed-effects model reveals a distinction between learning and performance in intensive reach training post-stroke

    OpenAIRE

    Park, Hyeshin; Schweighofer, Nicolas

    2017-01-01

    Background We recently showed that individuals with chronic stroke who completed two sessions of intensive unassisted arm reach training exhibited improvements in movement times up to one month post-training. Here, we study whether changes in movement times during training can predict long-term changes. Methods Sixteen participants with chronic stroke and ten non-disabled age-matched participants performed two sessions of reach training with 600 movements per session. Movement time data durin...

  4. Model of anisotropic nonlinearity in self-defocusing photorefractive media.

    Science.gov (United States)

    Barsi, C; Fleischer, J W

    2015-09-21

    We develop a phenomenological model of anisotropy in self-defocusing photorefractive crystals. In addition to an independent term due to nonlinear susceptibility, we introduce a nonlinear, non-separable correction to the spectral diffraction operator. The model successfully describes the crossover between photovoltaic and photorefractive responses and the spatially dispersive shock wave behavior of a nonlinearly spreading Gaussian input beam. It should prove useful for characterizing internal charge dynamics in complex materials and for accurate image reconstruction through nonlinear media.

  5. A flexible mixed-effect negative binomial regression model for detecting unusual increases in MRI lesion counts in individual multiple sclerosis patients.

    Science.gov (United States)

    Kondo, Yumi; Zhao, Yinshan; Petkau, John

    2015-06-15

    We develop a new modeling approach to enhance a recently proposed method to detect increases of contrast-enhancing lesions (CELs) on repeated magnetic resonance imaging, which have been used as an indicator for potential adverse events in multiple sclerosis clinical trials. The method signals patients with unusual increases in CEL activity by estimating the probability of observing CEL counts as large as those observed on a patient's recent scans conditional on the patient's CEL counts on previous scans. This conditional probability index (CPI), computed based on a mixed-effect negative binomial regression model, can vary substantially depending on the choice of distribution for the patient-specific random effects. Therefore, we relax this parametric assumption to model the random effects with an infinite mixture of beta distributions, using the Dirichlet process, which effectively allows any form of distribution. To our knowledge, no previous literature considers a mixed-effect regression for longitudinal count variables where the random effect is modeled with a Dirichlet process mixture. As our inference is in the Bayesian framework, we adopt a meta-analytic approach to develop an informative prior based on previous clinical trials. This is particularly helpful at the early stages of trials when less data are available. Our enhanced method is illustrated with CEL data from 10 previous multiple sclerosis clinical trials. Our simulation study shows that our procedure estimates the CPI more accurately than parametric alternatives when the patient-specific random effect distribution is misspecified and that an informative prior improves the accuracy of the CPI estimates. Copyright © 2015 John Wiley & Sons, Ltd.

  6. Nonlinear interaction model of subsonic jet noise.

    Science.gov (United States)

    Sandham, Neil D; Salgado, Adriana M

    2008-08-13

    Noise generation in a subsonic round jet is studied by a simplified model, in which nonlinear interactions of spatially evolving instability modes lead to the radiation of sound. The spatial mode evolution is computed using linear parabolized stability equations. Nonlinear interactions are found on a mode-by-mode basis and the sound radiation characteristics are determined by solution of the Lilley-Goldstein equation. Since mode interactions are computed explicitly, it is possible to find their relative importance for sound radiation. The method is applied to a single stream jet for which experimental data are available. The model gives Strouhal numbers of 0.45 for the most amplified waves in the jet and 0.19 for the dominant sound radiation. While in near field axisymmetric and the first azimuthal modes are both important, far-field sound is predominantly axisymmetric. These results are in close correspondence with experiment, suggesting that the simplified model is capturing at least some of the important mechanisms of subsonic jet noise.

  7. Nonlinear price impact from linear models

    Science.gov (United States)

    Patzelt, Felix; Bouchaud, Jean-Philippe

    2017-12-01

    The impact of trades on asset prices is a crucial aspect of market dynamics for academics, regulators, and practitioners alike. Recently, universal and highly nonlinear master curves were observed for price impacts aggregated on all intra-day scales (Patzelt and Bouchaud 2017 arXiv:1706.04163). Here we investigate how well these curves, their scaling, and the underlying return dynamics are captured by linear ‘propagator’ models. We find that the classification of trades as price-changing versus non-price-changing can explain the price impact nonlinearities and short-term return dynamics to a very high degree. The explanatory power provided by the change indicator in addition to the order sign history increases with increasing tick size. To obtain these results, several long-standing technical issues for model calibration and testing are addressed. We present new spectral estimators for two- and three-point cross-correlations, removing the need for previously used approximations. We also show when calibration is unbiased and how to accurately reveal previously overlooked biases. Therefore, our results contribute significantly to understanding both recent empirical results and the properties of a popular class of impact models.

  8. From spiking neuron models to linear-nonlinear models.

    Science.gov (United States)

    Ostojic, Srdjan; Brunel, Nicolas

    2011-01-20

    Neurons transform time-varying inputs into action potentials emitted stochastically at a time dependent rate. The mapping from current input to output firing rate is often represented with the help of phenomenological models such as the linear-nonlinear (LN) cascade, in which the output firing rate is estimated by applying to the input successively a linear temporal filter and a static non-linear transformation. These simplified models leave out the biophysical details of action potential generation. It is not a priori clear to which extent the input-output mapping of biophysically more realistic, spiking neuron models can be reduced to a simple linear-nonlinear cascade. Here we investigate this question for the leaky integrate-and-fire (LIF), exponential integrate-and-fire (EIF) and conductance-based Wang-Buzsáki models in presence of background synaptic activity. We exploit available analytic results for these models to determine the corresponding linear filter and static non-linearity in a parameter-free form. We show that the obtained functions are identical to the linear filter and static non-linearity determined using standard reverse correlation analysis. We then quantitatively compare the output of the corresponding linear-nonlinear cascade with numerical simulations of spiking neurons, systematically varying the parameters of input signal and background noise. We find that the LN cascade provides accurate estimates of the firing rates of spiking neurons in most of parameter space. For the EIF and Wang-Buzsáki models, we show that the LN cascade can be reduced to a firing rate model, the timescale of which we determine analytically. Finally we introduce an adaptive timescale rate model in which the timescale of the linear filter depends on the instantaneous firing rate. This model leads to highly accurate estimates of instantaneous firing rates.

  9. A vine copula mixed effect model for trivariate meta-analysis of diagnostic test accuracy studies accounting for disease prevalence.

    Science.gov (United States)

    Nikoloulopoulos, Aristidis K

    2017-10-01

    A bivariate copula mixed model has been recently proposed to synthesize diagnostic test accuracy studies and it has been shown that it is superior to the standard generalized linear mixed model in this context. Here, we call trivariate vine copulas to extend the bivariate meta-analysis of diagnostic test accuracy studies by accounting for disease prevalence. Our vine copula mixed model includes the trivariate generalized linear mixed model as a special case and can also operate on the original scale of sensitivity, specificity, and disease prevalence. Our general methodology is illustrated by re-analyzing the data of two published meta-analyses. Our study suggests that there can be an improvement on trivariate generalized linear mixed model in fit to data and makes the argument for moving to vine copula random effects models especially because of their richness, including reflection asymmetric tail dependence, and computational feasibility despite their three dimensionality.

  10. Nonlinear Model of Tape Wound Core Transformers

    Directory of Open Access Journals (Sweden)

    A. Vahedi

    2015-03-01

    Full Text Available Recently, tape wound cores due to their excellent magnetic properties, are widely used in different types of transformers. Performance prediction of these transformers needs an accurate model with ability to determine flux distribution within the core and magnetic loss. Spiral structure of tape wound cores affects the flux distribution and always cause complication of analysis. In this paper, a model based on reluctance networks method is presented for analysis of magnetic flux in wound cores. Using this model, distribution of longitudinal and transverse fluxes within the core can be determined. To consider the nonlinearity of the core, a dynamic hysteresis model is included in the presented model. Having flux density in different points of the core, magnetic losses can be calculated. To evaluate the validity of the model, results are compared with 2-D FEM simulations. In addition, a transformer designed for series-resonant converter and simulation results are compared with experimental measurements. Comparisons show accuracy of the model besides simplicity and fast convergence

  11. NONLINEAR PLANT PIECEWISE-CONTINUOUS MODEL MATRIX PARAMETERS ESTIMATION

    Directory of Open Access Journals (Sweden)

    Roman L. Leibov

    2017-09-01

    Full Text Available This paper presents a nonlinear plant piecewise-continuous model matrix parameters estimation technique using nonlinear model time responses and random search method. One of piecewise-continuous model application areas is defined. The results of proposed approach application for aircraft turbofan engine piecewisecontinuous model formation are presented

  12. A continuous-time adaptive particle filter for estimations under measurement time uncertainties with an application to a plasma-leucine mixed effects model.

    Science.gov (United States)

    Krengel, Annette; Hauth, Jan; Taskinen, Marja-Riitta; Adiels, Martin; Jirstrand, Mats

    2013-01-19

    When mathematical modelling is applied to many different application areas, a common task is the estimation of states and parameters based on measurements. With this kind of inference making, uncertainties in the time when the measurements have been taken are often neglected, but especially in applications taken from the life sciences, this kind of errors can considerably influence the estimation results. As an example in the context of personalized medicine, the model-based assessment of the effectiveness of drugs is becoming to play an important role. Systems biology may help here by providing good pharmacokinetic and pharmacodynamic (PK/PD) models. Inference on these systems based on data gained from clinical studies with several patient groups becomes a major challenge. Particle filters are a promising approach to tackle these difficulties but are by itself not ready to handle uncertainties in measurement times. In this article, we describe a variant of the standard particle filter (PF) algorithm which allows state and parameter estimation with the inclusion of measurement time uncertainties (MTU). The modified particle filter, which we call MTU-PF, also allows the application of an adaptive stepsize choice in the time-continuous case to avoid degeneracy problems. The modification is based on the model assumption of uncertain measurement times. While the assumption of randomness in the measurements themselves is common, the corresponding measurement times are generally taken as deterministic and exactly known. Especially in cases where the data are gained from measurements on blood or tissue samples, a relatively high uncertainty in the true measurement time seems to be a natural assumption. Our method is appropriate in cases where relatively few data are used from a relatively large number of groups or individuals, which introduce mixed effects in the model. This is a typical setting of clinical studies. We demonstrate the method on a small artificial example

  13. Using Akaike's information theoretic criterion in mixed-effects modeling of pharmacokinetic data: a simulation study [version 3; referees: 2 approved, 1 approved with reservations

    Directory of Open Access Journals (Sweden)

    Erik Olofsen

    2015-07-01

    Full Text Available Akaike's information theoretic criterion for model discrimination (AIC is often stated to "overfit", i.e., it selects models with a higher dimension than the dimension of the model that generated the data. However, with experimental pharmacokinetic data it may not be possible to identify the correct model, because of the complexity of the processes governing drug disposition. Instead of trying to find the correct model, a more useful objective might be to minimize the prediction error of drug concentrations in subjects with unknown disposition characteristics. In that case, the AIC might be the selection criterion of choice. We performed Monte Carlo simulations using a model of pharmacokinetic data (a power function of time with the property that fits with common multi-exponential models can never be perfect - thus resembling the situation with real data. Prespecified models were fitted to simulated data sets, and AIC and AICc (the criterion with a correction for small sample sizes values were calculated and averaged. The average predictive performances of the models, quantified using simulated validation sets, were compared to the means of the AICs. The data for fits and validation consisted of 11 concentration measurements each obtained in 5 individuals, with three degrees of interindividual variability in the pharmacokinetic volume of distribution. Mean AICc corresponded very well, and better than mean AIC, with mean predictive performance. With increasing interindividual variability, there was a trend towards larger optimal models, but with respect to both lowest AICc and best predictive performance. Furthermore, it was observed that the mean square prediction error itself became less suitable as a validation criterion, and that a predictive performance measure should incorporate interindividual variability. This simulation study showed that, at least in a relatively simple mixed-effects modelling context with a set of prespecified models

  14. Nonlinear Analysis and Modeling of Tires

    Science.gov (United States)

    Noor, Ahmed K.

    1996-01-01

    The objective of the study was to develop efficient modeling techniques and computational strategies for: (1) predicting the nonlinear response of tires subjected to inflation pressure, mechanical and thermal loads; (2) determining the footprint region, and analyzing the tire pavement contact problem, including the effect of friction; and (3) determining the sensitivity of the tire response (displacements, stresses, strain energy, contact pressures and contact area) to variations in the different material and geometric parameters. Two computational strategies were developed. In the first strategy the tire was modeled by using either a two-dimensional shear flexible mixed shell finite elements or a quasi-three-dimensional solid model. The contact conditions were incorporated into the formulation by using a perturbed Lagrangian approach. A number of model reduction techniques were applied to substantially reduce the number of degrees of freedom used in describing the response outside the contact region. The second strategy exploited the axial symmetry of the undeformed tire, and uses cylindrical coordinates in the development of three-dimensional elements for modeling each of the different parts of the tire cross section. Model reduction techniques are also used with this strategy.

  15. Nonlinear integral equations for the sausage model

    Science.gov (United States)

    Ahn, Changrim; Balog, Janos; Ravanini, Francesco

    2017-08-01

    The sausage model, first proposed by Fateev, Onofri, and Zamolodchikov, is a deformation of the O(3) sigma model preserving integrability. The target space is deformed from the sphere to ‘sausage’ shape by a deformation parameter ν. This model is defined by a factorizable S-matrix which is obtained by deforming that of the O(3) sigma model by a parameter λ. Clues for the deformed sigma model are provided by various UV and IR information through the thermodynamic Bethe ansatz (TBA) analysis based on the S-matrix. Application of TBA to the sausage model is, however, limited to the case of 1/λ integer where the coupled integral equations can be truncated to a finite number. In this paper, we propose a finite set of nonlinear integral equations (NLIEs), which are applicable to generic value of λ. Our derivation is based on T-Q relations extracted from the truncated TBA equations. For a consistency check, we compute next-leading order corrections of the vacuum energy and extract the S-matrix information in the IR limit. We also solved the NLIE both analytically and numerically in the UV limit to get the effective central charge and compared with that of the zero-mode dynamics to obtain exact relation between ν and λ. Dedicated to the memory of Petr Petrovich Kulish.

  16. Log-gamma linear-mixed effects models for multiple outcomes with application to a longitudinal glaucoma study

    Science.gov (United States)

    Zhang, Peng; Luo, Dandan; Li, Pengfei; Sharpsten, Lucie; Medeiros, Felipe A.

    2015-01-01

    Glaucoma is a progressive disease due to damage in the optic nerve with associated functional losses. Although the relationship between structural and functional progression in glaucoma is well established, there is disagreement on how this association evolves over time. In addressing this issue, we propose a new class of non-Gaussian linear-mixed models to estimate the correlations among subject-specific effects in multivariate longitudinal studies with a skewed distribution of random effects, to be used in a study of glaucoma. This class provides an efficient estimation of subject-specific effects by modeling the skewed random effects through the log-gamma distribution. It also provides more reliable estimates of the correlations between the random effects. To validate the log-gamma assumption against the usual normality assumption of the random effects, we propose a lack-of-fit test using the profile likelihood function of the shape parameter. We apply this method to data from a prospective observation study, the Diagnostic Innovations in Glaucoma Study, to present a statistically significant association between structural and functional change rates that leads to a better understanding of the progression of glaucoma over time. PMID:26075565

  17. Nonlinear Convective Models of RR Lyrae Stars

    Science.gov (United States)

    Feuchtinger, M.; Dorfi, E. A.

    The nonlinear behavior of RR Lyrae pulsations is investigated using a state-of-the-art numerical technique solving the full time-dependent system of radiation hydrodynamics. Grey radiative transfer is included by a variable Eddington-factor method and we use the time-dependent turbulent convection model according to Kuhfuss (1986, A&A 160, 116) in the version of Wuchterl (1995, Comp. Phys. Comm. 89, 19). OPAL opacities extended by the Alexander molecule opacities at temperatures below 6000 K and an equation of state according to Wuchterl (1990, A&A 238, 83) close the system. The resulting nonlinear system is discretized on an adaptive mesh developed by Dorfi & Drury (1987, J. Comp. Phys. 69, 175), which is important to provide the necessary spatial resolution in critical regions like ionization zones and shock waves. Additionally, we employ a second order advection scheme, a time centered temporal discretizaton and an artificial tensor viscosity in order to treat discontinuities. We compute fundamental as well first overtone models of RR Lyrae stars for a grid of stellar parameters both with and without convective energy transport in order to give a detailed picture of the pulsation-convection interaction. In order to investigate the influence of the different features of the convection model calculations with and without overshooting, turbulent pressure and turbulent viscosity are performed and compared with each other. A standard Fourier decomposition is used to confront the resulting light and radial velocity variations with recent observations and we show that the well known RR Lyrae phase discrepancy problem (Simon 1985, ApJ 299, 723) can be resolved with these stellar pulsation computations.

  18. Computational Models for Nonlinear Aeroelastic Systems, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Clear Science Corp. and Duke University propose to develop and demonstrate new and efficient computational methods of modeling nonlinear aeroelastic systems. The...

  19. Modelling nonlinear viscoelastic behaviours of loudspeaker suspensions-like structures

    Science.gov (United States)

    Maillou, Balbine; Lotton, Pierrick; Novak, Antonin; Simon, Laurent

    2018-03-01

    Mechanical properties of an electrodynamic loudspeaker are mainly determined by its suspensions (surround and spider) that behave nonlinearly and typically exhibit frequency dependent viscoelastic properties such as creep effect. The paper aims at characterizing the mechanical behaviour of electrodynamic loudspeaker suspensions at low frequencies using nonlinear identification techniques developed in recent years. A Generalized Hammerstein based model can take into account both frequency dependency and nonlinear properties. As shown in the paper, the model generalizes existing nonlinear or viscoelastic models commonly used for loudspeaker modelling. It is further experimentally shown that a possible input-dependent law may play a key role in suspension characterization.

  20. Model Updating Nonlinear System Identification Toolbox, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — ZONA Technology (ZONA) proposes to develop an enhanced model updating nonlinear system identification (MUNSID) methodology that utilizes flight data with...

  1. Comparing a single case to a control group - Applying linear mixed effects models to repeated measures data.

    Science.gov (United States)

    Huber, Stefan; Klein, Elise; Moeller, Korbinian; Willmes, Klaus

    2015-10-01

    In neuropsychological research, single-cases are often compared with a small control sample. Crawford and colleagues developed inferential methods (i.e., the modified t-test) for such a research design. In the present article, we suggest an extension of the methods of Crawford and colleagues employing linear mixed models (LMM). We first show that a t-test for the significance of a dummy coded predictor variable in a linear regression is equivalent to the modified t-test of Crawford and colleagues. As an extension to this idea, we then generalized the modified t-test to repeated measures data by using LMMs to compare the performance difference in two conditions observed in a single participant to that of a small control group. The performance of LMMs regarding Type I error rates and statistical power were tested based on Monte-Carlo simulations. We found that starting with about 15-20 participants in the control sample Type I error rates were close to the nominal Type I error rate using the Satterthwaite approximation for the degrees of freedom. Moreover, statistical power was acceptable. Therefore, we conclude that LMMs can be applied successfully to statistically evaluate performance differences between a single-case and a control sample. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Nonlinear structural mechanics theory, dynamical phenomena and modeling

    CERN Document Server

    Lacarbonara, Walter

    2013-01-01

    Nonlinear Structural Mechanics: Theory, Dynamical Phenomena and Modeling offers a concise, coherent presentation of the theoretical framework of nonlinear structural mechanics, computational methods, applications, parametric investigations of nonlinear phenomena and their mechanical interpretation towards design. The theoretical and computational tools that enable the formulation, solution, and interpretation of nonlinear structures are presented in a systematic fashion so as to gradually attain an increasing level of complexity of structural behaviors, under the prevailing assumptions on the geometry of deformation, the constitutive aspects and the loading scenarios. Readers will find a treatment of the foundations of nonlinear structural mechanics towards advanced reduced models, unified with modern computational tools in the framework of the prominent nonlinear structural dynamic phenomena while tackling both the mathematical and applied sciences. Nonlinear Structural Mechanics: Theory, Dynamical Phenomena...

  3. Nonlinear Rheology in a Model Biological Tissue

    Science.gov (United States)

    Matoz-Fernandez, D. A.; Agoritsas, Elisabeth; Barrat, Jean-Louis; Bertin, Eric; Martens, Kirsten

    2017-04-01

    The rheological response of dense active matter is a topic of fundamental importance for many processes in nature such as the mechanics of biological tissues. One prominent way to probe mechanical properties of tissues is to study their response to externally applied forces. Using a particle-based model featuring random apoptosis and environment-dependent division rates, we evidence a crossover from linear flow to a shear-thinning regime with an increasing shear rate. To rationalize this nonlinear flow we derive a theoretical mean-field scenario that accounts for the interplay of mechanical and active noise in local stresses. These noises are, respectively, generated by the elastic response of the cell matrix to cell rearrangements and by the internal activity.

  4. Coherent nonlinear quantum model for composite fermions

    Energy Technology Data Exchange (ETDEWEB)

    Reinisch, Gilbert [Science Institute, University of Iceland, Dunhaga 3, IS-107 Reykjavik (Iceland); Gudmundsson, Vidar, E-mail: vidar@hi.is [Science Institute, University of Iceland, Dunhaga 3, IS-107 Reykjavik (Iceland); Manolescu, Andrei [School of Science and Engineering, Reykjavik University, Menntavegur 1, IS-101 Reykjavik (Iceland)

    2014-04-01

    Originally proposed by Read [1] and Jain [2], the so-called “composite-fermion” is a phenomenological quasi-particle resulting from the attachment of two local flux quanta, seen as nonlocal vortices, to electrons situated on a two-dimensional (2D) surface embedded in a strong orthogonal magnetic field. In this Letter this phenomenon is described as a highly-nonlinear and coherent mean-field quantum process of the soliton type by use of a 2D stationary Schrödinger–Poisson differential model with only two Coulomb-interacting electrons. At filling factor ν=1/3 of the lowest Landau level the solution agrees with both the exact two-electron antisymmetric Schrödinger wavefunction and with Laughlin's Jastrow-type guess for the fractional quantum Hall effect, hence providing this latter with a tentative physical justification deduced from the experimental results and based on first principles.

  5. [Spatial heterogeneity in body condition of small yellow croaker in Yellow Sea and East China Sea based on mixed-effects model and quantile regression analysis].

    Science.gov (United States)

    Liu, Zun-Lei; Yuan, Xing-Wei; Yan, Li-Ping; Yang, Lin-Lin; Cheng, Jia-Hua

    2013-09-01

    By using the 2008-2010 investigation data about the body condition of small yellow croaker in the offshore waters of southern Yellow Sea (SYS), open waters of northern East China Sea (NECS), and offshore waters of middle East China Sea (MECS), this paper analyzed the spatial heterogeneity of body length-body mass of juvenile and adult small yellow croakers by the statistical approaches of mean regression model and quantile regression model. The results showed that the residual standard errors from the analysis of covariance (ANCOVA) and the linear mixed-effects model were similar, and those from the simple linear regression were the highest. For the juvenile small yellow croakers, their mean body mass in SYS and NECS estimated by the mixed-effects mean regression model was higher than the overall average mass across the three regions, while the mean body mass in MECS was below the overall average. For the adult small yellow croakers, their mean body mass in NECS was higher than the overall average, while the mean body mass in SYS and MECS was below the overall average. The results from quantile regression indicated the substantial differences in the allometric relationships of juvenile small yellow croakers between SYS, NECS, and MECS, with the estimated mean exponent of the allometric relationship in SYS being 2.85, and the interquartile range being from 2.63 to 2.96, which indicated the heterogeneity of body form. The results from ANCOVA showed that the allometric body length-body mass relationships were significantly different between the 25th and 75th percentile exponent values (F=6.38, df=1737, P<0.01) and the 25th percentile and median exponent values (F=2.35, df=1737, P=0.039). The relationship was marginally different between the median and 75th percentile exponent values (F=2.21, df=1737, P=0.051). The estimated body length-body mass exponent of adult small yellow croakers in SYS was 3.01 (10th and 95th percentiles = 2.77 and 3.1, respectively). The

  6. Nonlinear Kalman Filtering in Affine Term Structure Models

    DEFF Research Database (Denmark)

    Christoffersen, Peter; Dorion, Christian; Jacobs, Kris

    When the relationship between security prices and state variables in dynamic term structure models is nonlinear, existing studies usually linearize this relationship because nonlinear fi…ltering is computationally demanding. We conduct an extensive investigation of this linearization and analyze...... the potential of the unscented Kalman …filter to properly capture nonlinearities. To illustrate the advantages of the unscented Kalman …filter, we analyze the cross section of swap rates, which are relatively simple non-linear instruments, and cap prices, which are highly nonlinear in the states. An extensive...

  7. A simple numerical model of a geometrically nonlinear Timoshenko beam

    NARCIS (Netherlands)

    Keijdener, C.; Metrikine, A.

    2015-01-01

    In the original problem for which this model was developed, onedimensional flexible objects interact through a non-linear contact model. Due to the non-linear nature of the contact model, a numerical time-domain approach was adopted. One of the goals was to see if the coupling between axial and

  8. Nonlinear Eddy Viscosity Models applied to Wind Turbine Wakes

    DEFF Research Database (Denmark)

    Laan, van der, Paul Maarten; Sørensen, Niels N.; Réthoré, Pierre-Elouan

    2013-01-01

    The linear k−ε eddy viscosity model and modified versions of two existing nonlinear eddy viscosity models are applied to single wind turbine wake simulations using a Reynolds Averaged Navier-Stokes code. Results are compared with field wake measurements. The nonlinear models give better results...

  9. The Use of Mixed Effects Models for Obtaining Low-Cost Ecosystem Carbon Stock Estimates in Mangroves of the Asia-Pacific

    Science.gov (United States)

    Bukoski, J. J.; Broadhead, J. S.; Donato, D.; Murdiyarso, D.; Gregoire, T. G.

    2016-12-01

    Mangroves provide extensive ecosystem services that support both local livelihoods and international environmental goals, including coastal protection, water filtration, biodiversity conservation and the sequestration of carbon (C). While voluntary C market projects that seek to preserve and enhance forest C stocks offer a potential means of generating finance for mangrove conservation, their implementation faces barriers due to the high costs of quantifying C stocks through measurement, reporting and verification (MRV) activities. To streamline MRV activities in mangrove C forestry projects, we develop predictive models for (i) biomass-based C stocks, and (ii) soil-based C stocks for the mangroves of the Asia-Pacific. We use linear mixed effect models to account for spatial correlation in modeling the expected C as a function of stand attributes. The most parsimonious biomass model predicts total biomass C stocks as a function of both basal area and the interaction between latitude and basal area, whereas the most parsimonious soil C model predicts soil C stocks as a function of the logarithmic transformations of both latitude and basal area. Random effects are specified by site for both models, and are found to explain a substantial proportion of variance within the estimation datasets. The root mean square error (RMSE) of the biomass C model is approximated at 24.6 Mg/ha (18.4% of mean biomass C in the dataset), whereas the RMSE of the soil C model is estimated at 4.9 mg C/cm 3 (14.1% of mean soil C). A substantial proportion of the variation in soil C, however, is explained by the random effects and thus the use of the SOC model may be most valuable for sites in which field measurements of soil C exist.

  10. COMBINING LONG MEMORY AND NONLINEAR MODEL OUTPUTS FOR INFLATION FORECAST

    OpenAIRE

    Heri Kuswanto; Irhamah Alimuhajin; Laylia Afidah

    2014-01-01

    Long memory and nonlinearity have been proven as two models that are easily to be mistaken. In other words, nonlinearity is a strong candidate of spurious long memory by introducing a certain degree of fractional integration that lies in the region of long memory. Indeed, nonlinear process belongs to short memory with zero integration order. The idea of the forecast is to obtain the future condition with minimum error. Some researches argued that no matter what the model is, the important thi...

  11. Explicit Nonlinear Model Predictive Control Theory and Applications

    CERN Document Server

    Grancharova, Alexandra

    2012-01-01

    Nonlinear Model Predictive Control (NMPC) has become the accepted methodology to solve complex control problems related to process industries. The main motivation behind explicit NMPC is that an explicit state feedback law avoids the need for executing a numerical optimization algorithm in real time. The benefits of an explicit solution, in addition to the efficient on-line computations, include also verifiability of the implementation and the possibility to design embedded control systems with low software and hardware complexity. This book considers the multi-parametric Nonlinear Programming (mp-NLP) approaches to explicit approximate NMPC of constrained nonlinear systems, developed by the authors, as well as their applications to various NMPC problem formulations and several case studies. The following types of nonlinear systems are considered, resulting in different NMPC problem formulations: Ø  Nonlinear systems described by first-principles models and nonlinear systems described by black-box models; �...

  12. Worldwide impact of economic cycles on suicide trends over 3 decades: differences according to level of development. A mixed effect model study

    Science.gov (United States)

    Perez-Rodriguez, M Mercedes; Garcia-Nieto, Rebeca; Fernandez-Navarro, Pablo; Galfalvy, Hanga; de Leon, Jose; Baca-Garcia, Enrique

    2012-01-01

    Objectives To investigate the trends and correlations of gross domestic product (GDP) adjusted for purchasing power parity (PPP) per capita on suicide rates in 10 WHO regions during the past 30 years. Design Analyses of databases of PPP-adjusted GDP per capita and suicide rates. Countries were grouped according to the Global Burden of Disease regional classification system. Data sources World Bank's official website and WHO's mortality database. Statistical analyses After graphically displaying PPP-adjusted GDP per capita and suicide rates, mixed effect models were used for representing and analysing clustered data. Results Three different groups of countries, based on the correlation between the PPP-adjusted GDP per capita and suicide rates, are reported: (1) positive correlation: developing (lower middle and upper middle income) Latin-American and Caribbean countries, developing countries in the South East Asian Region including India, some countries in the Western Pacific Region (such as China and South Korea) and high-income Asian countries, including Japan; (2) negative correlation: high-income and developing European countries, Canada, Australia and New Zealand and (3) no correlation was found in an African country. Conclusions PPP-adjusted GDP per capita may offer a simple measure for designing the type of preventive interventions aimed at lowering suicide rates that can be used across countries. Public health interventions might be more suitable for developing countries. In high-income countries, however, preventive measures based on the medical model might prove more useful. PMID:22586285

  13. Nonlinear Growth Models in M"plus" and SAS

    Science.gov (United States)

    Grimm, Kevin J.; Ram, Nilam

    2009-01-01

    Nonlinear growth curves or growth curves that follow a specified nonlinear function in time enable researchers to model complex developmental patterns with parameters that are easily interpretable. In this article we describe how a variety of sigmoid curves can be fit using the M"plus" structural modeling program and the nonlinear…

  14. Modeling Non-Linear Material Properties in Composite Materials

    Science.gov (United States)

    2016-06-28

    Technical Report ARWSB-TR-16013 MODELING NON-LINEAR MATERIAL PROPERTIES IN COMPOSITE MATERIALS Michael F. Macri Andrew G...REPORT TYPE Technical 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE MODELING NON-LINEAR MATERIAL PROPERTIES IN COMPOSITE MATERIALS ...systems are increasingly incorporating composite materials into their design. Many of these systems subject the composites to environmental conditions

  15. Theoretical models for ultrashort electromagnetic pulse propagation in nonlinear metamaterials

    International Nuclear Information System (INIS)

    Wen, Shuangchun; Xiang, Yuanjiang; Dai, Xiaoyu; Tang, Zhixiang; Su, Wenhua; Fan, Dianyuan

    2007-01-01

    A metamaterial (MM) differs from an ordinary optical material mainly in that it has a dispersive magnetic permeability and offers greatly enhanced design freedom to alter the linear and nonlinear properties. This makes it possible for us to control the propagation of ultrashort electromagnetic pulses at will. Here we report on generic features of ultrashort electromagnetic pulse propagation and demonstrate the controllability of both the linear and nonlinear parameters of models for pulse propagation in MMs. First, we derive a generalized system of coupled three-dimensional nonlinear Schroedinger equations (NLSEs) suitable for few-cycle pulse propagation in a MM with both nonlinear electric polarization and nonlinear magnetization. The coupled equations recover previous models for pulse propagation in both ordinary material and a MM under the same conditions. Second, by using the coupled NLSEs in the Drude dispersive model as an example, we identify the respective roles of the dispersive electric permittivity and magnetic permeability in ultrashort pulse propagation and disclose some additional features of pulse propagation in MMs. It is shown that, for linear propagation, the sign and magnitude of space-time focusing can be controlled through adjusting the linear dispersive permittivity and permeability. For nonlinear propagation, the linear dispersive permittivity and permeability are incorporated into the nonlinear magnetization and nonlinear polarization, respectively, resulting in controllable magnetic and electric self-steepening effects and higher-order dispersively nonlinear terms in the propagation models

  16. Nonlinear observer design for a nonlinear string/cable FEM model using contraction theory

    DEFF Research Database (Denmark)

    Turkyilmaz, Yilmaz; Jouffroy, Jerome; Egeland, Olav

    model is presented in the form of partial differential equations (PDE). Galerkin's method is then applied to obtain a set of ordinary differential equations such that the cable model is approximated by a FEM model. Based on the FEM model, a nonlinear observer is designed to estimate the cable...

  17. Nonlinear flow model for well production in an underground formation

    Directory of Open Access Journals (Sweden)

    J. C. Guo

    2013-05-01

    Full Text Available Fluid flow in underground formations is a nonlinear process. In this article we modelled the nonlinear transient flow behaviour of well production in an underground formation. Based on Darcy's law and material balance equations, we used quadratic pressure gradients to deduce diffusion equations and discuss the origins of nonlinear flow issues. By introducing an effective-well-radius approach that considers skin factor, we established a nonlinear flow model for both gas and liquid (oil or water. The liquid flow model was solved using a semi-analytical method, while the gas flow model was solved using numerical simulations because the diffusion equation of gas flow is a stealth function of pressure. For liquid flow, a series of standard log-log type curves of pressure transients were plotted and nonlinear transient flow characteristics were analyzed. Qualitative and quantitative analyses were used to compare the solutions of the linear and nonlinear models. The effect of nonlinearity upon pressure transients should not be ignored. For gas flow, pressure transients were simulated and compared with oil flow under the same formation and well conditions, resulting in the conclusion that, under the same volume rate production, oil wells demand larger pressure drops than gas wells. Comparisons between theoretical data and field data show that nonlinear models will describe fluid flow in underground formations realistically and accurately.

  18. Model reduction of nonlinear systems subject to input disturbances

    KAUST Repository

    Ndoye, Ibrahima

    2017-07-10

    The method of convex optimization is used as a tool for model reduction of a class of nonlinear systems in the presence of disturbances. It is shown that under some conditions the nonlinear disturbed system can be approximated by a reduced order nonlinear system with similar disturbance-output properties to the original plant. The proposed model reduction strategy preserves the nonlinearity and the input disturbance nature of the model. It guarantees a sufficiently small error between the outputs of the original and the reduced-order systems, and also maintains the properties of input-to-state stability. The matrices of the reduced order system are given in terms of a set of linear matrix inequalities (LMIs). The paper concludes with a demonstration of the proposed approach on model reduction of a nonlinear electronic circuit with additive disturbances.

  19. Modeling of Nonlinear Beat Signals of TAE's

    Science.gov (United States)

    Zhang, Bo; Berk, Herbert; Breizman, Boris; Zheng, Linjin

    2012-03-01

    Experiments on Alcator C-Mod reveal Toroidal Alfven Eigenmodes (TAE) together with signals at various beat frequencies, including those at twice the mode frequency. The beat frequencies are sidebands driven by quadratic nonlinear terms in the MHD equations. These nonlinear sidebands have not yet been quantified by any existing codes. We extend the AEGIS code to capture nonlinear effects by treating the nonlinear terms as a driving source in the linear MHD solver. Our goal is to compute the spatial structure of the sidebands for realistic geometry and q-profile, which can be directly compared with experiment in order to interpret the phase contrast imaging diagnostic measurements and to enable the quantitative determination of the Alfven wave amplitude in the plasma core

  20. Model reduction tools for nonlinear structural dynamics

    NARCIS (Netherlands)

    Slaats, P.M.A.; Jongh, de J.; Sauren, A.A.H.J.

    1995-01-01

    Three mode types are proposed for reducing nonlinear dynamical system equations, resulting from finite element discretizations: tangent modes, modal derivatives, and newly added static modes. Tangent modes are obtained from an eigenvalue problem with a momentary tangent stiffness matrix. Their

  1. Applications of Nonlinear Dynamics Model and Design of Complex Systems

    CERN Document Server

    In, Visarath; Palacios, Antonio

    2009-01-01

    This edited book is aimed at interdisciplinary, device-oriented, applications of nonlinear science theory and methods in complex systems. In particular, applications directed to nonlinear phenomena with space and time characteristics. Examples include: complex networks of magnetic sensor systems, coupled nano-mechanical oscillators, nano-detectors, microscale devices, stochastic resonance in multi-dimensional chaotic systems, biosensors, and stochastic signal quantization. "applications of nonlinear dynamics: model and design of complex systems" brings together the work of scientists and engineers that are applying ideas and methods from nonlinear dynamics to design and fabricate complex systems.

  2. Individual differences in boys' and girls' timing and tempo of puberty: modeling development with nonlinear growth models.

    Science.gov (United States)

    Marceau, Kristine; Ram, Nilam; Houts, Renate M; Grimm, Kevin J; Susman, Elizabeth J

    2011-09-01

    Pubertal development is a nonlinear process progressing from prepubescent beginnings through biological, physical, and psychological changes to full sexual maturity. To tether theoretical concepts of puberty with sophisticated longitudinal, analytical models capable of articulating pubertal development more accurately, we used nonlinear mixed-effects models to describe both the timing and tempo of pubertal development in the sample of 364 White boys and 373 White girls measured across 6 years as part of the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development. Individual differences in timing and tempo were extracted with models of logistic growth. Differential relations emerged for how boys' and girls' timing and tempo of development were related to physical characteristics (body mass index, height, and weight) and psychological outcomes (internalizing problems, externalizing problems, and risky sexual behavior). Timing and tempo are associated in boys but not girls. Pubertal timing and tempo are particularly important for predicting psychological outcomes in girls but only sparsely related to boys' psychological outcomes. Results highlight the importance of considering the nonlinear nature of puberty and expand the repertoire of possibilities for examining important aspects of how and when pubertal processes contribute to development.

  3. Nonlinear Modeling of the PEMFC Based On NNARX Approach

    OpenAIRE

    Shan-Jen Cheng; Te-Jen Chang; Kuang-Hsiung Tan; Shou-Ling Kuo

    2015-01-01

    Polymer Electrolyte Membrane Fuel Cell (PEMFC) is such a time-vary nonlinear dynamic system. The traditional linear modeling approach is hard to estimate structure correctly of PEMFC system. From this reason, this paper presents a nonlinear modeling of the PEMFC using Neural Network Auto-regressive model with eXogenous inputs (NNARX) approach. The multilayer perception (MLP) network is applied to evaluate the structure of the NNARX model of PEMFC. The validity and accurac...

  4. Nonlinear State Space Modeling and System Identification for Electrohydraulic Control

    Directory of Open Access Journals (Sweden)

    Jun Yan

    2013-01-01

    Full Text Available The paper deals with nonlinear modeling and identification of an electrohydraulic control system for improving its tracking performance. We build the nonlinear state space model for analyzing the highly nonlinear system and then develop a Hammerstein-Wiener (H-W model which consists of a static input nonlinear block with two-segment polynomial nonlinearities, a linear time-invariant dynamic block, and a static output nonlinear block with single polynomial nonlinearity to describe it. We simplify the H-W model into a linear-in-parameters structure by using the key term separation principle and then use a modified recursive least square method with iterative estimation of internal variables to identify all the unknown parameters simultaneously. It is found that the proposed H-W model approximates the actual system better than the independent Hammerstein, Wiener, and ARX models. The prediction error of the H-W model is about 13%, 54%, and 58% less than the Hammerstein, Wiener, and ARX models, respectively.

  5. Physics constrained nonlinear regression models for time series

    International Nuclear Information System (INIS)

    Majda, Andrew J; Harlim, John

    2013-01-01

    A central issue in contemporary science is the development of data driven statistical nonlinear dynamical models for time series of partial observations of nature or a complex physical model. It has been established recently that ad hoc quadratic multi-level regression (MLR) models can have finite-time blow up of statistical solutions and/or pathological behaviour of their invariant measure. Here a new class of physics constrained multi-level quadratic regression models are introduced, analysed and applied to build reduced stochastic models from data of nonlinear systems. These models have the advantages of incorporating memory effects in time as well as the nonlinear noise from energy conserving nonlinear interactions. The mathematical guidelines for the performance and behaviour of these physics constrained MLR models as well as filtering algorithms for their implementation are developed here. Data driven applications of these new multi-level nonlinear regression models are developed for test models involving a nonlinear oscillator with memory effects and the difficult test case of the truncated Burgers–Hopf model. These new physics constrained quadratic MLR models are proposed here as process models for Bayesian estimation through Markov chain Monte Carlo algorithms of low frequency behaviour in complex physical data. (paper)

  6. Variational Boussinesq model for strongly nonlinear dispersive waves

    NARCIS (Netherlands)

    Lawrence, C.; Adytia, D.; van Groesen, E.

    2018-01-01

    For wave tank, coastal and oceanic applications, a fully nonlinear Variational Boussinesq model with optimized dispersion is derived and a simple Finite Element implementation is described. Improving a previous weakly nonlinear version, high waves over flat and varying bottom are shown to be

  7. Model reduction of nonlinear systems subject to input disturbances

    KAUST Repository

    Ndoye, Ibrahima; Laleg-Kirati, Taous-Meriem

    2017-01-01

    The method of convex optimization is used as a tool for model reduction of a class of nonlinear systems in the presence of disturbances. It is shown that under some conditions the nonlinear disturbed system can be approximated by a reduced order

  8. Phenomenological modeling of nonlinear holograms based on metallic geometric metasurfaces.

    Science.gov (United States)

    Ye, Weimin; Li, Xin; Liu, Juan; Zhang, Shuang

    2016-10-31

    Benefiting from efficient local phase and amplitude control at the subwavelength scale, metasurfaces offer a new platform for computer generated holography with high spatial resolution. Three-dimensional and high efficient holograms have been realized by metasurfaces constituted by subwavelength meta-atoms with spatially varying geometries or orientations. Metasurfaces have been recently extended to the nonlinear optical regime to generate holographic images in harmonic generation waves. Thus far, there has been no vector field simulation of nonlinear metasurface holograms because of the tremendous computational challenge in numerically calculating the collective nonlinear responses of the large number of different subwavelength meta-atoms in a hologram. Here, we propose a general phenomenological method to model nonlinear metasurface holograms based on the assumption that every meta-atom could be described by a localized nonlinear polarizability tensor. Applied to geometric nonlinear metasurfaces, we numerically model the holographic images formed by the second-harmonic waves of different spins. We show that, in contrast to the metasurface holograms operating in the linear optical regime, the wavelength of incident fundamental light should be slightly detuned from the fundamental resonant wavelength to optimize the efficiency and quality of nonlinear holographic images. The proposed modeling provides a general method to simulate nonlinear optical devices based on metallic metasurfaces.

  9. Nonlinear adaptive inverse control via the unified model neural network

    Science.gov (United States)

    Jeng, Jin-Tsong; Lee, Tsu-Tian

    1999-03-01

    In this paper, we propose a new nonlinear adaptive inverse control via a unified model neural network. In order to overcome nonsystematic design and long training time in nonlinear adaptive inverse control, we propose the approximate transformable technique to obtain a Chebyshev Polynomials Based Unified Model (CPBUM) neural network for the feedforward/recurrent neural networks. It turns out that the proposed method can use less training time to get an inverse model. Finally, we apply this proposed method to control magnetic bearing system. The experimental results show that the proposed nonlinear adaptive inverse control architecture provides a greater flexibility and better performance in controlling magnetic bearing systems.

  10. Nonlinear Model Predictive Control with Constraint Satisfactions for a Quadcopter

    Science.gov (United States)

    Wang, Ye; Ramirez-Jaime, Andres; Xu, Feng; Puig, Vicenç

    2017-01-01

    This paper presents a nonlinear model predictive control (NMPC) strategy combined with constraint satisfactions for a quadcopter. The full dynamics of the quadcopter describing the attitude and position are nonlinear, which are quite sensitive to changes of inputs and disturbances. By means of constraint satisfactions, partial nonlinearities and modeling errors of the control-oriented model of full dynamics can be transformed into the inequality constraints. Subsequently, the quadcopter can be controlled by an NMPC controller with the updated constraints generated by constraint satisfactions. Finally, the simulation results applied to a quadcopter simulator are provided to show the effectiveness of the proposed strategy.

  11. Is gender policy related to the gender gap in external cause and circulatory disease mortality? A mixed effects model of 22 OECD countries 1973–2008

    Directory of Open Access Journals (Sweden)

    Backhans Mona

    2012-11-01

    Full Text Available Abstract Background Gender differences in mortality vary widely between countries and over time, but few studies have examined predictors of these variations, apart from smoking. The aim of this study is to investigate the link between gender policy and the gender gap in cause-specific mortality, adjusted for economic factors and health behaviours. Methods 22 OECD countries were followed 1973–2008 and the outcomes were gender gaps in external cause and circulatory disease mortality. A previously found country cluster solution was used, which includes indicators on taxes, parental leave, pensions, social insurances and social services in kind. Male breadwinner countries were made reference group and compared to earner-carer, compensatory breadwinner, and universal citizen countries. Specific policies were also analysed. Mixed effect models were used, where years were the level 1-units, and countries were the level 2-units. Results Both the earner-carer cluster (ns after adjustment for GDP and policies characteristic of that cluster are associated with smaller gender differences in external causes, particularly due to an association with increased female mortality. Cluster differences in the gender gap in circulatory disease mortality are the result of a larger relative decrease of male mortality in the compensatory breadwinner cluster and the earner-carer cluster. Policies characteristic of those clusters were however generally related to increased mortality. Conclusion Results for external cause mortality are in concordance with the hypothesis that women become more exposed to risks of accident and violence when they are economically more active. For circulatory disease mortality, results differ depending on approach – cluster or indicator. Whether cluster differences not explained by specific policies reflect other welfare policies or unrelated societal trends is an open question. Recommendations for further studies are made.

  12. Heterotic sigma models and non-linear strings

    International Nuclear Information System (INIS)

    Hull, C.M.

    1986-01-01

    The two-dimensional supersymmetric non-linear sigma models are examined with respect to the heterotic string. The paper was presented at the workshop on :Supersymmetry and its applications', Cambridge, United Kingdom, 1985. The non-linear sigma model with Wess-Zumino-type term, the coupling of the fermionic superfields to the sigma model, super-conformal invariance, and the supersymmetric string, are all discussed. (U.K.)

  13. A deep belief network with PLSR for nonlinear system modeling.

    Science.gov (United States)

    Qiao, Junfei; Wang, Gongming; Li, Wenjing; Li, Xiaoli

    2017-10-31

    Nonlinear system modeling plays an important role in practical engineering, and deep learning-based deep belief network (DBN) is now popular in nonlinear system modeling and identification because of the strong learning ability. However, the existing weights optimization for DBN is based on gradient, which always leads to a local optimum and a poor training result. In this paper, a DBN with partial least square regression (PLSR-DBN) is proposed for nonlinear system modeling, which focuses on the problem of weights optimization for DBN using PLSR. Firstly, unsupervised contrastive divergence (CD) algorithm is used in weights initialization. Secondly, initial weights derived from CD algorithm are optimized through layer-by-layer PLSR modeling from top layer to bottom layer. Instead of gradient method, PLSR-DBN can determine the optimal weights using several PLSR models, so that a better performance of PLSR-DBN is achieved. Then, the analysis of convergence is theoretically given to guarantee the effectiveness of the proposed PLSR-DBN model. Finally, the proposed PLSR-DBN is tested on two benchmark nonlinear systems and an actual wastewater treatment system as well as a handwritten digit recognition (nonlinear mapping and modeling) with high-dimension input data. The experiment results show that the proposed PLSR-DBN has better performances of time and accuracy on nonlinear system modeling than that of other methods. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Model Updating Nonlinear System Identification Toolbox, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — ZONA Technology proposes to develop an enhanced model updating nonlinear system identification (MUNSID) methodology by adopting the flight data with state-of-the-art...

  15. Sphaleron in a non-linear sigma model

    International Nuclear Information System (INIS)

    Sogo, Kiyoshi; Fujimoto, Yasushi.

    1989-08-01

    We present an exact classical saddle point solution in a non-linear sigma model. It has a topological charge 1/2 and mediates the vacuum transition. The quantum fluctuations and the transition rate are also examined. (author)

  16. Computational Models for Nonlinear Aeroelastic Systems, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Clear Science Corp. and Duke University propose to develop and demonstrate a new and efficient computational method of modeling nonlinear aeroelastic systems. The...

  17. forecasting with nonlinear time series model: a monte-carlo

    African Journals Online (AJOL)

    PUBLICATIONS1

    Carlo method of forecasting using a special nonlinear time series model, called logistic smooth transition ... We illustrate this new method using some simulation ..... in MATLAB 7.5.0. ... process (DGP) using the logistic smooth transi-.

  18. Discretization model for nonlinear dynamic analysis of three dimensional structures

    International Nuclear Information System (INIS)

    Hayashi, Y.

    1982-12-01

    A discretization model for nonlinear dynamic analysis of three dimensional structures is presented. The discretization is achieved through a three dimensional spring-mass system and the dynamic response obtained by direct integration of the equations of motion using central diferences. First the viability of the model is verified through the analysis of homogeneous linear structures and then its performance in the analysis of structures subjected to impulsive or impact loads, taking into account both geometrical and physical nonlinearities is evaluated. (Author) [pt

  19. Nonlinear signal processing using neural networks: Prediction and system modelling

    Energy Technology Data Exchange (ETDEWEB)

    Lapedes, A.; Farber, R.

    1987-06-01

    The backpropagation learning algorithm for neural networks is developed into a formalism for nonlinear signal processing. We illustrate the method by selecting two common topics in signal processing, prediction and system modelling, and show that nonlinear applications can be handled extremely well by using neural networks. The formalism is a natural, nonlinear extension of the linear Least Mean Squares algorithm commonly used in adaptive signal processing. Simulations are presented that document the additional performance achieved by using nonlinear neural networks. First, we demonstrate that the formalism may be used to predict points in a highly chaotic time series with orders of magnitude increase in accuracy over conventional methods including the Linear Predictive Method and the Gabor-Volterra-Weiner Polynomial Method. Deterministic chaos is thought to be involved in many physical situations including the onset of turbulence in fluids, chemical reactions and plasma physics. Secondly, we demonstrate the use of the formalism in nonlinear system modelling by providing a graphic example in which it is clear that the neural network has accurately modelled the nonlinear transfer function. It is interesting to note that the formalism provides explicit, analytic, global, approximations to the nonlinear maps underlying the various time series. Furthermore, the neural net seems to be extremely parsimonious in its requirements for data points from the time series. We show that the neural net is able to perform well because it globally approximates the relevant maps by performing a kind of generalized mode decomposition of the maps. 24 refs., 13 figs.

  20. Nonlinear dynamics new directions models and applications

    CERN Document Server

    Ugalde, Edgardo

    2015-01-01

    This book, along with its companion volume, Nonlinear Dynamics New Directions: Theoretical Aspects, covers topics ranging from fractal analysis to very specific applications of the theory of dynamical systems to biology. This second volume contains mostly new applications of the theory of dynamical systems to both engineering and biology. The first volume is devoted to fundamental aspects and includes a number of important new contributions as well as some review articles that emphasize new development prospects. The topics addressed in the two volumes include a rigorous treatment of fluctuations in dynamical systems, topics in fractal analysis, studies of the transient dynamics in biological networks, synchronization in lasers, and control of chaotic systems, among others. This book also: ·         Develops applications of nonlinear dynamics on a diversity of topics such as patterns of synchrony in neuronal networks, laser synchronization, control of chaotic systems, and the study of transient dynam...

  1. Special class of nonlinear damping models in flexible space structures

    Science.gov (United States)

    Hu, Anren; Singh, Ramendra P.; Taylor, Lawrence W.

    1991-01-01

    A special class of nonlinear damping models is investigated in which the damping force is proportional to the product of positive integer or the fractional power of the absolute values of displacement and velocity. For a one-degree-of-freedom system, the classical Krylov-Bogoliubov 'averaging' method is used, whereas for a distributed system, both an ad hoc perturbation technique and the finite difference method are employed to study the effects of nonlinear damping. The results are compared with linear viscous damping models. The amplitude decrement of free vibration for a single mode system with nonlinear models depends not only on the damping ratio but also on the initial amplitude, the time to measure the response, the frequency of the system, and the powers of displacement and velocity. For the distributed system, the action of nonlinear damping is found to reduce the energy of the system and to pass energy to lower modes.

  2. A finite element model for nonlinear shells of revolution

    International Nuclear Information System (INIS)

    Cook, W.A.

    1979-01-01

    A shell-of-revolution model was developed to analyze impact problems associated with the safety analysis of nuclear material shipping containers. The nonlinear shell theory presented by Eric Reissner in 1972 was used to develop our model. Reissner's approach includes transverse shear deformation and moments turning about the middle surface normal. With these features, this approach is valid for both thin and thick shells. His theory is formulated in terms of strain and stress resultants that refer to the undeformed geometry. This nonlinear shell model is developed using the virtual work principle associated with Reissner's equilibrium equations. First, the virtual work principle is modified for incremental loading; then it is linearized by assuming that the nonlinear portions of the strains are known. By iteration, equilibrium is then approximated for each increment. A benefit of this approach is that this iteration process makes it possible to use nonlinear material properties. (orig.)

  3. Nonlinear mirror mode dynamics: Simulations and modeling

    Czech Academy of Sciences Publication Activity Database

    Califano, F.; Hellinger, Petr; Kuznetsov, E.; Passot, T.; Sulem, P. L.; Trávníček, Pavel

    2008-01-01

    Roč. 113, - (2008), A08219/1-A08219/20 ISSN 0148-0227 R&D Projects: GA AV ČR IAA300420702; GA AV ČR IAA300420602 Grant - others:PECS(CZ) 98024 Institutional research plan: CEZ:AV0Z30420517 Keywords : mirror instability * nonlinear evolution * numerical simulations * magnetic holes * mirror structures * kinetic plasma instabilities Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 3.147, year: 2008

  4. Joint model-based clustering of nonlinear longitudinal trajectories and associated time-to-event data analysis, linked by latent class membership: with application to AIDS clinical studies.

    Science.gov (United States)

    Huang, Yangxin; Lu, Xiaosun; Chen, Jiaqing; Liang, Juan; Zangmeister, Miriam

    2017-10-27

    Longitudinal and time-to-event data are often observed together. Finite mixture models are currently used to analyze nonlinear heterogeneous longitudinal data, which, by releasing the homogeneity restriction of nonlinear mixed-effects (NLME) models, can cluster individuals into one of the pre-specified classes with class membership probabilities. This clustering may have clinical significance, and be associated with clinically important time-to-event data. This article develops a joint modeling approach to a finite mixture of NLME models for longitudinal data and proportional hazard Cox model for time-to-event data, linked by individual latent class indicators, under a Bayesian framework. The proposed joint models and method are applied to a real AIDS clinical trial data set, followed by simulation studies to assess the performance of the proposed joint model and a naive two-step model, in which finite mixture model and Cox model are fitted separately.

  5. Practical Soil-Shallow Foundation Model for Nonlinear Structural Analysis

    Directory of Open Access Journals (Sweden)

    Moussa Leblouba

    2016-01-01

    Full Text Available Soil-shallow foundation interaction models that are incorporated into most structural analysis programs generally lack accuracy and efficiency or neglect some aspects of foundation behavior. For instance, soil-shallow foundation systems have been observed to show both small and large loops under increasing amplitude load reversals. This paper presents a practical macroelement model for soil-shallow foundation system and its stability under simultaneous horizontal and vertical loads. The model comprises three spring elements: nonlinear horizontal, nonlinear rotational, and linear vertical springs. The proposed macroelement model was verified using experimental test results from large-scale model foundations subjected to small and large cyclic loading cases.

  6. A REMARK ON FORMAL MODELS FOR NONLINEARLY ELASTIC MEMBRANE SHELLS

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    This paper gives all the two-dimensional membrane models obtained from formal asymptotic analysis of the three-dimensional geometrically exact nonlinear model of a thin elastic shell made with a Saint Venant-Kirchhoff material. Therefore, the other models can be quoted as flexural nonlinear ones. The author also gives the formal equations solved by the associated stress tensor and points out that only one of those models leads, by linearization, to the “classical” linear limiting membrane model, whose juetification has already been established by a convergence theorem.

  7. Convex models and probabilistic approach of nonlinear fatigue failure

    International Nuclear Information System (INIS)

    Qiu Zhiping; Lin Qiang; Wang Xiaojun

    2008-01-01

    This paper is concerned with the nonlinear fatigue failure problem with uncertainties in the structural systems. In the present study, in order to solve the nonlinear problem by convex models, the theory of ellipsoidal algebra with the help of the thought of interval analysis is applied. In terms of the inclusion monotonic property of ellipsoidal functions, the nonlinear fatigue failure problem with uncertainties can be solved. A numerical example of 25-bar truss structures is given to illustrate the efficiency of the presented method in comparison with the probabilistic approach

  8. Physics, Nonlinear Time Series Analysis, Data Assimilation and Hyperfast Modeling of Nonlinear Ocean Waves

    Science.gov (United States)

    2010-09-30

    Hyperfast Modeling of Nonlinear Ocean Waves A. R. Osborne Dipartimento di Fisica Generale, Università di Torino Via Pietro Giuria 1, 10125...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Universit?i Torino,Dipartimento di Fisica Generale,Via Pietro Giuria 1,10125 Torino, Italy, 8. PERFORMING

  9. A nonlinear complementarity approach for the national energy modeling system

    International Nuclear Information System (INIS)

    Gabriel, S.A.; Kydes, A.S.

    1995-01-01

    The National Energy Modeling System (NEMS) is a large-scale mathematical model that computes equilibrium fuel prices and quantities in the U.S. energy sector. At present, to generate these equilibrium values, NEMS sequentially solves a collection of linear programs and nonlinear equations. The NEMS solution procedure then incorporates the solutions of these linear programs and nonlinear equations in a nonlinear Gauss-Seidel approach. The authors describe how the current version of NEMS can be formulated as a particular nonlinear complementarity problem (NCP), thereby possibly avoiding current convergence problems. In addition, they show that the NCP format is equally valid for a more general form of NEMS. They also describe several promising approaches for solving the NCP form of NEMS based on recent Newton type methods for general NCPs. These approaches share the feature of needing to solve their direction-finding subproblems only approximately. Hence, they can effectively exploit the sparsity inherent in the NEMS NCP

  10. Inference of a Nonlinear Stochastic Model of the Cardiorespiratory Interaction

    Science.gov (United States)

    Smelyanskiy, V. N.; Luchinsky, D. G.; Stefanovska, A.; McClintock, P. V.

    2005-03-01

    We reconstruct a nonlinear stochastic model of the cardiorespiratory interaction in terms of a set of polynomial basis functions representing the nonlinear force governing system oscillations. The strength and direction of coupling and noise intensity are simultaneously inferred from a univariate blood pressure signal. Our new inference technique does not require extensive global optimization, and it is applicable to a wide range of complex dynamical systems subject to noise.

  11. Recent Advances in Explicit Multiparametric Nonlinear Model Predictive Control

    KAUST Repository

    Domínguez, Luis F.

    2011-01-19

    In this paper we present recent advances in multiparametric nonlinear programming (mp-NLP) algorithms for explicit nonlinear model predictive control (mp-NMPC). Three mp-NLP algorithms for NMPC are discussed, based on which novel mp-NMPC controllers are derived. The performance of the explicit controllers are then tested and compared in a simulation example involving the operation of a continuous stirred-tank reactor (CSTR). © 2010 American Chemical Society.

  12. Modeling of nonlinear biological phenomena modeled by S-systems.

    Science.gov (United States)

    Mansouri, Majdi M; Nounou, Hazem N; Nounou, Mohamed N; Datta, Aniruddha A

    2014-03-01

    A central challenge in computational modeling of biological systems is the determination of the model parameters. In such cases, estimating these variables or parameters from other easily obtained measurements can be extremely useful. For example, time-series dynamic genomic data can be used to develop models representing dynamic genetic regulatory networks, which can be used to design intervention strategies to cure major diseases and to better understand the behavior of biological systems. Unfortunately, biological measurements are usually highly infected by errors that hide the important characteristics in the data. Therefore, these noisy measurements need to be filtered to enhance their usefulness in practice. This paper addresses the problem of state and parameter estimation of biological phenomena modeled by S-systems using Bayesian approaches, where the nonlinear observed system is assumed to progress according to a probabilistic state space model. The performances of various conventional and state-of-the-art state estimation techniques are compared. These techniques include the extended Kalman filter (EKF), unscented Kalman filter (UKF), particle filter (PF), and the developed variational Bayesian filter (VBF). Specifically, two comparative studies are performed. In the first comparative study, the state variables (the enzyme CadA, the model cadBA, the cadaverine Cadav and the lysine Lys for a model of the Cad System in Escherichia coli (CSEC)) are estimated from noisy measurements of these variables, and the various estimation techniques are compared by computing the estimation root mean square error (RMSE) with respect to the noise-free data. In the second comparative study, the state variables as well as the model parameters are simultaneously estimated. In this case, in addition to comparing the performances of the various state estimation techniques, the effect of the number of estimated model parameters on the accuracy and convergence of these

  13. Fuzzy model-based servo and model following control for nonlinear systems.

    Science.gov (United States)

    Ohtake, Hiroshi; Tanaka, Kazuo; Wang, Hua O

    2009-12-01

    This correspondence presents servo and nonlinear model following controls for a class of nonlinear systems using the Takagi-Sugeno fuzzy model-based control approach. First, the construction method of the augmented fuzzy system for continuous-time nonlinear systems is proposed by differentiating the original nonlinear system. Second, the dynamic fuzzy servo controller and the dynamic fuzzy model following controller, which can make outputs of the nonlinear system converge to target points and to outputs of the reference system, respectively, are introduced. Finally, the servo and model following controller design conditions are given in terms of linear matrix inequalities. Design examples illustrate the utility of this approach.

  14. Symmetries and discretizations of the O(3) nonlinear sigma model

    Energy Technology Data Exchange (ETDEWEB)

    Flore, Raphael [TPI, Universitaet Jena (Germany)

    2011-07-01

    Nonlinear sigma models possess many interesting properties like asymptotic freedom, confinement or dynamical mass generation, and hence serve as toy models for QCD and other theories. We derive a formulation of the N=2 supersymmetric extension of the O(3) nonlinear sigma model in terms of constrained field variables. Starting from this formulation, it is discussed how the model can be discretized in a way that maintains as many symmetries of the theory as possible. Finally, recent numerical results related to these discretizations are presented.

  15. Modeling and nonlinear heading control for sailing yachts

    DEFF Research Database (Denmark)

    Xiao, Lin; Jouffroy, Jerome

    2014-01-01

    This paper presents a study on the development and testing of a model-based heading controller for a sailing yacht. Using Fossen’s compact notation for marine vehicles, we first describe a nonlinear four-degree-of-freedom (DOF) dynamic model for a sailing yacht, including roll. Our model also...

  16. Modeling and nonlinear heading control for sailing yachts

    DEFF Research Database (Denmark)

    Xiao, Lin; Jouffroy, Jerome

    2011-01-01

    This paper presents a study on the development and testing of a model-based heading controller for a sailing yacht. Using Fossen's compact notation for marine vehicles, we first describe a nonlinear 4-DOF dynamic model for a sailing yacht, including roll. Starting from this model, we then design...

  17. Unstructured Spectral Element Model for Dispersive and Nonlinear Wave Propagation

    DEFF Research Database (Denmark)

    Engsig-Karup, Allan Peter; Eskilsson, Claes; Bigoni, Daniele

    2016-01-01

    We introduce a new stabilized high-order and unstructured numerical model for modeling fully nonlinear and dispersive water waves. The model is based on a nodal spectral element method of arbitrary order in space and a -transformed formulation due to Cai, Langtangen, Nielsen and Tveito (1998). In...

  18. A Versatile Nonlinear Method for Predictive Modeling

    Science.gov (United States)

    Liou, Meng-Sing; Yao, Weigang

    2015-01-01

    As computational fluid dynamics techniques and tools become widely accepted for realworld practice today, it is intriguing to ask: what areas can it be utilized to its potential in the future. Some promising areas include design optimization and exploration of fluid dynamics phenomena (the concept of numerical wind tunnel), in which both have the common feature where some parameters are varied repeatedly and the computation can be costly. We are especially interested in the need for an accurate and efficient approach for handling these applications: (1) capturing complex nonlinear dynamics inherent in a system under consideration and (2) versatility (robustness) to encompass a range of parametric variations. In our previous paper, we proposed to use first-order Taylor expansion collected at numerous sampling points along a trajectory and assembled together via nonlinear weighting functions. The validity and performance of this approach was demonstrated for a number of problems with a vastly different input functions. In this study, we are especially interested in enhancing the method's accuracy; we extend it to include the second-orer Taylor expansion, which however requires a complicated evaluation of Hessian matrices for a system of equations, like in fluid dynamics. We propose a method to avoid these Hessian matrices, while maintaining the accuracy. Results based on the method are presented to confirm its validity.

  19. An Improved Nonlinear Five-Point Model for Photovoltaic Modules

    Directory of Open Access Journals (Sweden)

    Sakaros Bogning Dongue

    2013-01-01

    Full Text Available This paper presents an improved nonlinear five-point model capable of analytically describing the electrical behaviors of a photovoltaic module for each generic operating condition of temperature and solar irradiance. The models used to replicate the electrical behaviors of operating PV modules are usually based on some simplified assumptions which provide convenient mathematical model which can be used in conventional simulation tools. Unfortunately, these assumptions cause some inaccuracies, and hence unrealistic economic returns are predicted. As an alternative, we used the advantages of a nonlinear analytical five-point model to take into account the nonideal diode effects and nonlinear effects generally ignored, which PV modules operation depends on. To verify the capability of our method to fit PV panel characteristics, the procedure was tested on three different panels. Results were compared with the data issued by manufacturers and with the results obtained using the five-parameter model proposed by other authors.

  20. Study of the nonlinear imperfect software debugging model

    International Nuclear Information System (INIS)

    Wang, Jinyong; Wu, Zhibo

    2016-01-01

    In recent years there has been a dramatic proliferation of research on imperfect software debugging phenomena. Software debugging is a complex process and is affected by a variety of factors, including the environment, resources, personnel skills, and personnel psychologies. Therefore, the simple assumption that debugging is perfect is inconsistent with the actual software debugging process, wherein a new fault can be introduced when removing a fault. Furthermore, the fault introduction process is nonlinear, and the cumulative number of nonlinearly introduced faults increases over time. Thus, this paper proposes a nonlinear, NHPP imperfect software debugging model in consideration of the fact that fault introduction is a nonlinear process. The fitting and predictive power of the NHPP-based proposed model are validated through related experiments. Experimental results show that this model displays better fitting and predicting performance than the traditional NHPP-based perfect and imperfect software debugging models. S-confidence bounds are set to analyze the performance of the proposed model. This study also examines and discusses optimal software release-time policy comprehensively. In addition, this research on the nonlinear process of fault introduction is significant given the recent surge of studies on software-intensive products, such as cloud computing and big data. - Highlights: • Fault introduction is a nonlinear changing process during the debugging phase. • The assumption that the process of fault introduction is nonlinear is credible. • Our proposed model can better fit and accurately predict software failure behavior. • Research on fault introduction case is significant to software-intensive products.

  1. Modelling and control of a nonlinear magnetostrictive actuator system

    Science.gov (United States)

    Ramli, M. H. M.; Majeed, A. P. P. Abdul; Anuar, M. A. M.; Mohamed, Z.

    2018-04-01

    This paper explores the implementation of a feedforward control method to a nonlinear control system, in particular, Magnetostrictive Actuators (MA) that has excellent properties of energy conversion between the mechanical and magnetic form through magnetostriction effects which could be used in actuating and sensing application. MA is known to exhibit hysteresis behaviour and it is rate dependent (the level of hysteresis depends closely on the rate of input excitation frequency). This is, nonetheless, an undesirable behaviour and has to be eliminated in realising high precision application. The MA is modelled by a phenomenological modelling approach via Prandtl-Ishlinskii (P-I) operator to characterise the hysteresis nonlinearities. A feedforward control strategy is designed and implemented to linearize and eliminate the hysteresis by model inversion. The results show that the P-I operator has the capability to model the hysteretic nonlinearity of MA with an acceptable accuracy. Furthermore, the proposed control scheme has demonstrated to be effective in providing superior trajectory tracking.

  2. A Simple Model for Nonlinear Confocal Ultrasonic Beams

    Science.gov (United States)

    Zhang, Dong; Zhou, Lin; Si, Li-Sheng; Gong, Xiu-Fen

    2007-01-01

    A confocally and coaxially arranged pair of focused transmitter and receiver represents one of the best geometries for medical ultrasonic imaging and non-invasive detection. We develop a simple theoretical model for describing the nonlinear propagation of a confocal ultrasonic beam in biological tissues. On the basis of the parabolic approximation and quasi-linear approximation, the nonlinear Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation is solved by using the angular spectrum approach. Gaussian superposition technique is applied to simplify the solution, and an analytical solution for the second harmonics in the confocal ultrasonic beam is presented. Measurements are performed to examine the validity of the theoretical model. This model provides a preliminary model for acoustic nonlinear microscopy.

  3. Modeling TAE Response To Nonlinear Drives

    Science.gov (United States)

    Zhang, Bo; Berk, Herbert; Breizman, Boris; Zheng, Linjin

    2012-10-01

    Experiment has detected the Toroidal Alfven Eigenmodes (TAE) with signals at twice the eigenfrequency.These harmonic modes arise from the second order perturbation in amplitude of the MHD equation for the linear modes that are driven the energetic particle free energy. The structure of TAE in realistic geometry can be calculated by generalizing the linear numerical solver (AEGIS package). We have have inserted all the nonlinear MHD source terms, where are quadratic in the linear amplitudes, into AEGIS code. We then invert the linear MHD equation at the second harmonic frequency. The ratio of amplitudes of the first and second harmonic terms are used to determine the internal field amplitude. The spatial structure of energy and density distribution are investigated. The results can be directly employed to compare with experiments and determine the Alfven wave amplitude in the plasma region.

  4. Modeling Autoregressive Processes with Moving-Quantiles-Implied Nonlinearity

    Directory of Open Access Journals (Sweden)

    Isao Ishida

    2015-01-01

    Full Text Available We introduce and investigate some properties of a class of nonlinear time series models based on the moving sample quantiles in the autoregressive data generating process. We derive a test fit to detect this type of nonlinearity. Using the daily realized volatility data of Standard & Poor’s 500 (S&P 500 and several other indices, we obtained good performance using these models in an out-of-sample forecasting exercise compared with the forecasts obtained based on the usual linear heterogeneous autoregressive and other models of realized volatility.

  5. Dissipative quantum dynamics and nonlinear sigma-model

    International Nuclear Information System (INIS)

    Tarasov, V.E.

    1992-01-01

    Sedov variational principle which is the generalization of the least action principle for the dissipative and irreversible processes and the classical dissipative mechanics in the phase space is considered. Quantum dynamics for the dissipative and irreversible processes is constructed. As an example of the dissipative quantum theory the nonlinear two-dimensional sigma-model is considered. The conformal anomaly of the energy momentum tensor trace for closed bosonic string on the affine-metric manifold is investigated. The two-loop metric beta-function for nonlinear dissipative sigma-model was calculated. The results are compared with the ultraviolet two-loop conterterms for affine-metric sigma model. 71 refs

  6. A Comparative Study Of Stock Price Forecasting Using Nonlinear Models

    Directory of Open Access Journals (Sweden)

    Diteboho Xaba

    2017-03-01

    Full Text Available This study compared the in-sample forecasting accuracy of three forecasting nonlinear models namely: the Smooth Transition Regression (STR model, the Threshold Autoregressive (TAR model and the Markov-switching Autoregressive (MS-AR model. Nonlinearity tests were used to confirm the validity of the assumptions of the study. The study used model selection criteria, SBC to select the optimal lag order and for the selection of appropriate models. The Mean Square Error (MSE, Mean Absolute Error (MAE and Root Mean Square Error (RMSE served as the error measures in evaluating the forecasting ability of the models. The MS-AR models proved to perform well with lower error measures as compared to LSTR and TAR models in most cases.

  7. forecasting with nonlinear time series model: a monte-carlo

    African Journals Online (AJOL)

    PUBLICATIONS1

    erated recursively up to any step greater than one. For nonlinear time series model, point forecast for step one can be done easily like in the linear case but forecast for a step greater than or equal to ..... London. Franses, P. H. (1998). Time series models for business and Economic forecasting, Cam- bridge University press.

  8. Nonlinear Dynamics of a Helicopter Model in Ground Resonance

    Science.gov (United States)

    Tang, D. M.; Dowell, E. H.

    1985-01-01

    An approximate theoretical method is presented which determined the limit cycle behavior of a helicopter model which has one or two nonlinear dampers. The relationship during unstable ground resonance oscillations between lagging motion of the blades and fuselage motion is discussed. An experiment was carried out on using a helicopter scale model. The experimental results agree with those of the theoretical analysis.

  9. Linear and Nonlinear Career Models: Metaphors, Paradigms, and Ideologies.

    Science.gov (United States)

    Buzzanell, Patrice M.; Goldzwig, Steven R.

    1991-01-01

    Examines the linear or bureaucratic career models (dominant in career research, metaphors, paradigms, and ideologies) which maintain career myths of flexibility and individualized routes to success in organizations incapable of offering such versatility. Describes nonlinear career models which offer suggestive metaphors for re-visioning careers…

  10. Modeling of nonlinear responses for reciprocal transducers involving polarization switching

    DEFF Research Database (Denmark)

    Willatzen, Morten; Wang, Linxiang

    2007-01-01

    Nonlinearities and hysteresis effects in a reciprocal PZT transducer are examined by use of a dynamical mathematical model on the basis of phase-transition theory. In particular, we consider the perovskite piezoelectric ceramic in which the polarization process in the material can be modeled...... by Landau theory for the first-order phase transformation, in which each polarization state is associated with a minimum of the Landau free-energy function. Nonlinear constitutive laws are obtained by using thermodynamical equilibrium conditions, and hysteretic behavior of the material can be modeled...... intrinsically. The time-dependent Ginzburg-Landau theory is used in the parameter identification involving hysteresis effects. We use the Chebyshev collocation method in the numerical simulations. The elastic field is assumed to be coupled linearly with other fields, and the nonlinearity is in the E-D coupling...

  11. An analog model for quantum lightcone fluctuations in nonlinear optics

    International Nuclear Information System (INIS)

    Ford, L.H.; De Lorenci, V.A.; Menezes, G.; Svaiter, N.F.

    2013-01-01

    We propose an analog model for quantum gravity effects using nonlinear dielectrics. Fluctuations of the spacetime lightcone are expected in quantum gravity, leading to variations in the flight times of pulses. This effect can also arise in a nonlinear material. We propose a model in which fluctuations of a background electric field, such as that produced by a squeezed photon state, can cause fluctuations in the effective lightcone for probe pulses. This leads to a variation in flight times analogous to that in quantum gravity. We make some numerical estimates which suggest that the effect might be large enough to be observable. - Highlights: ► Lightcone fluctuations, quantum fluctuations of the effective speed of light, are a feature of quantum gravity. ► Nonlinear dielectrics have a variable speed of light, analogous to the effects of gravity. ► Fluctuating electric fields create the effect of lightcone fluctuations in a nonlinear material. ► We propose to use squeezed light in a nonlinear material as an analog model of lightcone fluctuations. ► Variation in the speed of propagation of pulses is the observational signature of lightcone fluctuations.

  12. Nonlinear Dynamic Modeling of Langevin-Type Piezoelectric Transducers

    Directory of Open Access Journals (Sweden)

    Nicolás Peréz Alvarez

    2015-11-01

    Full Text Available Langevin transducers are employed in several applications, such as power ultrasound systems, naval hydrophones, and high-displacement actuators. Nonlinear effects can influence their performance, especially at high vibration amplitude levels. These nonlinear effects produce variations in the resonant frequency, harmonics of the excitation frequency, in addition to loss of symmetry in the frequency response and “frequency domain hysteresis”. In this context, this paper presents a simplified nonlinear dynamic model of power ultrasound transducers requiring only two parameters for simulating the most relevant nonlinear effects. One parameter reproduces the changes in the resonance frequency and the other introduces the dependence of the frequency response on the history of the system. The piezoelectric constitutive equations are extended by a linear dependence of the elastic constant on the mechanical displacement amplitude. For introducing the frequency hysteresis, the elastic constant is computed by combining the current value of the mechanical amplitude with the previous state amplitude. The model developed in this work is applied for predicting the dynamic responses of a 26 kHz ultrasonic transducer. The comparison of theoretical and experimental responses, obtained at several input voltages around the tuned frequency, shows a good agreement, indicating that the model can accurately describe the transducer nonlinear behavior.

  13. Optimization of the time series NDVI-rainfall relationship using linear mixed-effects modeling for the anti-desertification area in the Beijing and Tianjin sandstorm source region

    Science.gov (United States)

    Wang, Jin; Sun, Tao; Fu, Anmin; Xu, Hao; Wang, Xinjie

    2018-05-01

    Degradation in drylands is a critically important global issue that threatens ecosystem and environmental in many ways. Researchers have tried to use remote sensing data and meteorological data to perform residual trend analysis and identify human-induced vegetation changes. However, complex interactions between vegetation and climate, soil units and topography have not yet been considered. Data used in the study included annual accumulated Moderate Resolution Imaging Spectroradiometer (MODIS) 250 m normalized difference vegetation index (NDVI) from 2002 to 2013, accumulated rainfall from September to August, digital elevation model (DEM) and soil units. This paper presents linear mixed-effect (LME) modeling methods for the NDVI-rainfall relationship. We developed linear mixed-effects models that considered the random effects of sample points nested in soil units for nested two-level modeling and single-level modeling of soil units and sample points, respectively. Additionally, three functions, including the exponential function (exp), the power function (power), and the constant plus power function (CPP), were tested to remove heterogeneity, and an additional three correlation structures, including the first-order autoregressive structure [AR(1)], a combination of first-order autoregressive and moving average structures [ARMA(1,1)] and the compound symmetry structure (CS), were used to address the spatiotemporal correlations. It was concluded that the nested two-level model considering both heteroscedasticity with (CPP) and spatiotemporal correlation with [ARMA(1,1)] showed the best performance (AMR = 0.1881, RMSE = 0.2576, adj- R 2 = 0.9593). Variations between soil units and sample points that may have an effect on the NDVI-rainfall relationship should be included in model structures, and linear mixed-effects modeling achieves this in an effective and accurate way.

  14. Note on off-shell relations in nonlinear sigma model

    International Nuclear Information System (INIS)

    Chen, Gang; Du, Yi-Jian; Li, Shuyi; Liu, Hanqing

    2015-01-01

    In this note, we investigate relations between tree-level off-shell currents in nonlinear sigma model. Under Cayley parametrization, all odd-point currents vanish. We propose and prove a generalized U(1) identity for even-point currents. The off-shell U(1) identity given in http://dx.doi.org/10.1007/JHEP01(2014)061 is a special case of the generalized identity studied in this note. The on-shell limit of this identity is equivalent with the on-shell KK relation. Thus this relation provides the full off-shell correspondence of tree-level KK relation in nonlinear sigma model.

  15. Likelihood-Based Inference in Nonlinear Error-Correction Models

    DEFF Research Database (Denmark)

    Kristensen, Dennis; Rahbæk, Anders

    We consider a class of vector nonlinear error correction models where the transfer function (or loadings) of the stationary relation- ships is nonlinear. This includes in particular the smooth transition models. A general representation theorem is given which establishes the dynamic properties...... and a linear trend in general. Gaussian likelihood-based estimators are considered for the long- run cointegration parameters, and the short-run parameters. Asymp- totic theory is provided for these and it is discussed to what extend asymptotic normality and mixed normaity can be found. A simulation study...

  16. Nonlinear thermal reduced model for Microwave Circuit Analysis

    OpenAIRE

    Chang, Christophe; Sommet, Raphael; Quéré, Raymond; Dueme, Ph.

    2004-01-01

    With the constant increase of transistor power density, electro thermal modeling is becoming a necessity for accurate prediction of device electrical performances. For this reason, this paper deals with a methodology to obtain a precise nonlinear thermal model based on Model Order Reduction of a three dimensional thermal Finite Element (FE) description. This reduced thermal model is based on the Ritz vector approach which ensure the steady state solution in every case. An equi...

  17. Testing and Inference in Nonlinear Cointegrating Vector Error Correction Models

    DEFF Research Database (Denmark)

    Kristensen, Dennis; Rahbæk, Anders

    In this paper, we consider a general class of vector error correction models which allow for asymmetric and non-linear error correction. We provide asymptotic results for (quasi-)maximum likelihood (QML) based estimators and tests. General hypothesis testing is considered, where testing...... of non-stationary non-linear time series models. Thus the paper provides a full asymptotic theory for estimators as well as standard and non-standard test statistics. The derived asymptotic results prove to be new compared to results found elsewhere in the literature due to the impact of the estimated...... symmetric non-linear error correction considered. A simulation study shows that the fi…nite sample properties of the bootstrapped tests are satisfactory with good size and power properties for reasonable sample sizes....

  18. Testing and Inference in Nonlinear Cointegrating Vector Error Correction Models

    DEFF Research Database (Denmark)

    Kristensen, Dennis; Rahbek, Anders

    In this paper, we consider a general class of vector error correction models which allow for asymmetric and non-linear error correction. We provide asymptotic results for (quasi-)maximum likelihood (QML) based estimators and tests. General hypothesis testing is considered, where testing...... of non-stationary non-linear time series models. Thus the paper provides a full asymptotic theory for estimators as well as standard and non-standard test statistics. The derived asymptotic results prove to be new compared to results found elsewhere in the literature due to the impact of the estimated...... symmetric non-linear error correction are considered. A simulation study shows that the finite sample properties of the bootstrapped tests are satisfactory with good size and power properties for reasonable sample sizes....

  19. Mathematical models for suspension bridges nonlinear structural instability

    CERN Document Server

    Gazzola, Filippo

    2015-01-01

    This work provides a detailed and up-to-the-minute survey of the various stability problems that can affect suspension bridges. In order to deduce some experimental data and rules on the behavior of suspension bridges, a number of historical events are first described, in the course of which several questions concerning their stability naturally arise. The book then surveys conventional mathematical models for suspension bridges and suggests new nonlinear alternatives, which can potentially supply answers to some stability questions. New explanations are also provided, based on the nonlinear structural behavior of bridges. All the models and responses presented in the book employ the theory of differential equations and dynamical systems in the broader sense, demonstrating that methods from nonlinear analysis can allow us to determine the thresholds of instability.

  20. Modeling and non-linear responses of MEMS capacitive accelerometer

    Directory of Open Access Journals (Sweden)

    Sri Harsha C.

    2014-01-01

    Full Text Available A theoretical investigation of an electrically actuated beam has been illustrated when the electrostatic-ally actuated micro-cantilever beam is separated from the electrode by a moderately large gap for two distinct types of geometric configurations of MEMS accelerometer. Higher order nonlinear terms have been taken into account for studying the pull in voltage analysis. A nonlinear model of gas film squeezing damping, another source of nonlinearity in MEMS devices is included in obtaining the dynamic responses. Moreover, in the present work, the possible source of nonlinearities while formulating the mathematical model of a MEMS accelerometer and their influences on the dynamic responses have been investigated. The theoretical results obtained by using MATLAB has been verified with the results obtained in FE software and has been found in good agreement. Criterion towards stable micro size accelerometer for each configuration has been investigated. This investigation clearly provides an understanding of nonlinear static and dynamics characteristics of electrostatically micro cantilever based device in MEMS.

  1. Modelling of a bridge-shaped nonlinear piezoelectric energy harvester

    International Nuclear Information System (INIS)

    Gafforelli, G; Corigliano, A; Xu, R; Kim, S G

    2013-01-01

    Piezoelectric MicroElectroMechanical Systems (MEMS) energy harvesting is an attractive technology for harvesting small magnitudes of energy from ambient vibrations. Increasing the operating frequency bandwidth of such devices is one of the major issues for real world applications. A MEMS-scale doubly clamped nonlinear beam resonator is designed and developed to demonstrate very wide bandwidth and high power density. In this paper a first complete theoretical discussion of nonlinear resonating piezoelectric energy harvesting is provided. The sectional behaviour of the beam is studied through the Classical Lamination Theory (CLT) specifically modified to introduce the piezoelectric coupling and nonlinear Green-Lagrange strain tensor. A lumped parameter model is built through Rayleigh-Ritz Method and the resulting nonlinear coupled equations are solved in the frequency domain through the Harmonic Balance Method (HBM). Finally, the influence of external load resistance on the dynamic behaviour is studied. The theoretical model shows that nonlinear resonant harvesters have much wider power bandwidth than that of linear resonators but their maximum power is still bounded by the mechanical damping as is the case for linear resonating harvesters

  2. Nonlinear Dynamic Model of PMBLDC Motor Considering Core Losses

    DEFF Research Database (Denmark)

    Fasil, Muhammed; Mijatovic, Nenad; Jensen, Bogi Bech

    2017-01-01

    The phase variable model is used commonly when simulating a motor drive system with a three-phase permanent magnet brushless DC (PMBLDC) motor. The phase variable model neglects core losses and this affects its accuracy when modelling fractional-slot machines. The inaccuracy of phase variable mod...... on the detailed analysis of the flux path and the variation of flux in different components of the machine. A prototype of fractional slot axial flux PMBLDC in-wheel motor is used to assess the proposed nonlinear dynamic model....... of fractional-slot machines can be attributed to considerable armature flux harmonics, which causes an increased core loss. This study proposes a nonlinear phase variable model of PMBLDC motor that considers the core losses induced in the stator and the rotor. The core loss model is developed based...

  3. Global Nonlinear Model Identification with Multivariate Splines

    NARCIS (Netherlands)

    De Visser, C.C.

    2011-01-01

    At present, model based control systems play an essential role in many aspects of modern society. Application areas of model based control systems range from food processing to medical imaging, and from process control in oil refineries to the flight control systems of modern aircraft. Central to a

  4. Current algebra of classical non-linear sigma models

    International Nuclear Information System (INIS)

    Forger, M.; Laartz, J.; Schaeper, U.

    1992-01-01

    The current algebra of classical non-linear sigma models on arbitrary Riemannian manifolds is analyzed. It is found that introducing, in addition to the Noether current j μ associated with the global symmetry of the theory, a composite scalar field j, the algebra closes under Poisson brackets. (orig.)

  5. Dynamics of breathers in discrete nonlinear Schrodinger models

    DEFF Research Database (Denmark)

    Christiansen, Peter Leth; Johansson, Magnus; Aubry, Serge

    1998-01-01

    We review some recent results concerning the existence and stability of spatially localized and temporally quasiperiodic (non-stationary) excitations in discrete nonlinear Schrodinger (DNLS) models. In two dimensions, we show the existence of linearly stable, stationary and non-stationary localized...

  6. Control mechanisms for a nonlinear model of international relations

    Energy Technology Data Exchange (ETDEWEB)

    Pentek, A.; Kadtke, J. [Univ. of California, San Diego, La Jolla, CA (United States). Inst. for Pure and Applied Physical Sciences; Lenhart, S. [Univ. of Tennessee, Knoxville, TN (United States). Mathematics Dept.; Protopopescu, V. [Oak Ridge National Lab., TN (United States). Computer Science and Mathematics Div.

    1997-07-15

    Some issues of control in complex dynamical systems are considered. The authors discuss two control mechanisms, namely: a short range, reactive control based on the chaos control idea and a long-term strategic control based on an optimal control algorithm. They apply these control ideas to simple examples in a discrete nonlinear model of a multi-nation arms race.

  7. S-AMP for non-linear observation models

    DEFF Research Database (Denmark)

    Cakmak, Burak; Winther, Ole; Fleury, Bernard H.

    2015-01-01

    Recently we presented the S-AMP approach, an extension of approximate message passing (AMP), to be able to handle general invariant matrix ensembles. In this contribution we extend S-AMP to non-linear observation models. We obtain generalized AMP (GAMP) as the special case when the measurement...

  8. Two-dimensional effects in nonlinear Kronig-Penney models

    DEFF Research Database (Denmark)

    Gaididei, Yuri Borisovich; Christiansen, Peter Leth; Rasmussen, Kim

    1997-01-01

    An analysis of two-dimensional (2D) effects in the nonlinear Kronig-Penney model is presented. We establish an effective one-dimensional description of the 2D effects, resulting in a set of pseudodifferential equations. The stationary states of the 2D system and their stability is studied...

  9. Modelling the nonlinearity of piezoelectric actuators in active ...

    African Journals Online (AJOL)

    Piezoelectric actuators have great capabilities as elements of intelligent structures for active vibration cancellation. One problem with this type of actuator is its nonlinear behaviour. In active vibration control systems, it is important to have an accurate model of the control branch. This paper demonstrates the ability of neural ...

  10. Hybrid time/frequency domain modeling of nonlinear components

    DEFF Research Database (Denmark)

    Wiechowski, Wojciech Tomasz; Lykkegaard, Jan; Bak, Claus Leth

    2007-01-01

    This paper presents a novel, three-phase hybrid time/frequency methodology for modelling of nonlinear components. The algorithm has been implemented in the DIgSILENT PowerFactory software using the DIgSILENT Programming Language (DPL), as a part of the work described in [1]. Modified HVDC benchmark...

  11. A non-linear dissipative model of magnetism

    Czech Academy of Sciences Publication Activity Database

    Durand, P.; Paidarová, Ivana

    2010-01-01

    Roč. 89, č. 6 (2010), s. 67004 ISSN 1286-4854 R&D Projects: GA AV ČR IAA100400501 Institutional research plan: CEZ:AV0Z40400503 Keywords : non-linear dissipative model of magnetism * thermodynamics * physical chemistry Subject RIV: CF - Physical ; Theoretical Chemistry http://epljournal.edpsciences.org/

  12. Modeling and verifying non-linearities in heterodyne displacement interferometry

    NARCIS (Netherlands)

    Cosijns, S.J.A.G.; Haitjema, H.; Schellekens, P.H.J.

    2002-01-01

    The non-linearities in a heterodyne laser interferometer system occurring from the phase measurement system of the interferometer andfrom non-ideal polarization effects of the optics are modeled into one analytical expression which includes the initial polarization state ofthe laser source, the

  13. Multidimensional splines for modeling FET nonlinearities

    Energy Technology Data Exchange (ETDEWEB)

    Barby, J A

    1986-01-01

    Circuit simulators like SPICE and timing simulators like MOTIS are used extensively for critical path verification of integrated circuits. MOSFET model evaluation dominates the run time of these simulators. Changes in technology results in costly updates, since modifications require reprogramming of the functions and their derivatives. The computational cost of MOSFET models can be reduced by using multidimensional polynomial splines. Since simulators based on the Newton Raphson algorithm require the function and first derivative, quadratic splines are sufficient for this purpose. The cost of updating the MOSFET model due to technology changes is greatly reduced since splines are derived from a set of points. Crucial for convergence speed of simulators is the fact that MOSFET characteristic equations are monotonic. This must be maintained by any simulation model. The splines the author designed do maintain monotonicity.

  14. Identification of stochastic interactions in nonlinear models of structural mechanics

    Science.gov (United States)

    Kala, Zdeněk

    2017-07-01

    In the paper, the polynomial approximation is presented by which the Sobol sensitivity analysis can be evaluated with all sensitivity indices. The nonlinear FEM model is approximated. The input area is mapped using simulations runs of Latin Hypercube Sampling method. The domain of the approximation polynomial is chosen so that it were possible to apply large number of simulation runs of Latin Hypercube Sampling method. The method presented also makes possible to evaluate higher-order sensitivity indices, which could not be identified in case of nonlinear FEM.

  15. Measurement Model Nonlinearity in Estimation of Dynamical Systems

    Science.gov (United States)

    Majji, Manoranjan; Junkins, J. L.; Turner, J. D.

    2012-06-01

    The role of nonlinearity of the measurement model and its interactions with the uncertainty of measurements and geometry of the problem is studied in this paper. An examination of the transformations of the probability density function in various coordinate systems is presented for several astrodynamics applications. Smooth and analytic nonlinear functions are considered for the studies on the exact transformation of uncertainty. Special emphasis is given to understanding the role of change of variables in the calculus of random variables. The transformation of probability density functions through mappings is shown to provide insight in to understanding the evolution of uncertainty in nonlinear systems. Examples are presented to highlight salient aspects of the discussion. A sequential orbit determination problem is analyzed, where the transformation formula provides useful insights for making the choice of coordinates for estimation of dynamic systems.

  16. Model Reduction of Nonlinear Aeroelastic Systems Experiencing Hopf Bifurcation

    KAUST Repository

    Abdelkefi, Abdessattar

    2013-06-18

    In this paper, we employ the normal form to derive a reduced - order model that reproduces nonlinear dynamical behavior of aeroelastic systems that undergo Hopf bifurcation. As an example, we consider a rigid two - dimensional airfoil that is supported by nonlinear springs in the pitch and plunge directions and subjected to nonlinear aerodynamic loads. We apply the center manifold theorem on the governing equations to derive its normal form that constitutes a simplified representation of the aeroelastic sys tem near flutter onset (manifestation of Hopf bifurcation). Then, we use the normal form to identify a self - excited oscillator governed by a time - delay ordinary differential equation that approximates the dynamical behavior while reducing the dimension of the original system. Results obtained from this oscillator show a great capability to predict properly limit cycle oscillations that take place beyond and above flutter as compared with the original aeroelastic system.

  17. Modelization of highly nonlinear waves in coastal regions

    Science.gov (United States)

    Gouin, Maïté; Ducrozet, Guillaume; Ferrant, Pierre

    2015-04-01

    The proposed work deals with the development of a highly non-linear model for water wave propagation in coastal regions. The accurate modelization of surface gravity waves is of major interest in ocean engineering, especially in the field of marine renewable energy. These marine structures are intended to be settled in coastal regions where the effect of variable bathymetry may be significant on local wave conditions. This study presents a numerical model for the wave propagation with complex bathymetry. It is based on High-Order Spectral (HOS) method, initially limited to the propagation of non-linear wave fields over flat bottom. Such a model has been developed and validated at the LHEEA Lab. (Ecole Centrale Nantes) over the past few years and the current developments will enlarge its application range. This new numerical model will keep the interesting numerical properties of the original pseudo-spectral approach (convergence, efficiency with the use of FFTs, …) and enable the possibility to propagate highly non-linear wave fields over long time and large distance. Different validations will be provided in addition to the presentation of the method. At first, Bragg reflection will be studied with the proposed approach. If the Bragg condition is satisfied, the reflected wave generated by a sinusoidal bottom patch should be amplified as a result of resonant quadratic interactions between incident wave and bottom. Comparisons will be provided with experiments and reference solutions. Then, the method will be used to consider the transformation of a non-linear monochromatic wave as it propagates up and over a submerged bar. As the waves travel up the front slope of the bar, it steepens and high harmonics are generated due to non-linear interactions. Comparisons with experimental data will be provided. The different test cases will assess the accuracy and efficiency of the method proposed.

  18. Nonlinear dynamic phenomena in the beer model

    DEFF Research Database (Denmark)

    Mosekilde, Erik; Laugesen, Jakob Lund

    2007-01-01

    The production-distribution system or "beer game" is one of the most well-known system dynamics models. Notorious for the complex dynamics it produces, the beer game has been used for nearly five decades to illustrate how structure generates behavior and to explore human decision making. Here we...

  19. Nonlinear Modelling of Low Frequency Loudspeakers

    DEFF Research Database (Denmark)

    Olsen, Erling Sandermann; Christensen, Knud Bank

    1996-01-01

    A central part of the Danish LoDist project has been the derivation of an extended equivalent circuit and a corresponding set of differential equations suitable for the simulation of high-fidelity woofers under large and very large (clipping) signal conditions. A model including suspension creep ...

  20. Nonclassical measurements errors in nonlinear models

    DEFF Research Database (Denmark)

    Madsen, Edith; Mulalic, Ismir

    Discrete choice models and in particular logit type models play an important role in understanding and quantifying individual or household behavior in relation to transport demand. An example is the choice of travel mode for a given trip under the budget and time restrictions that the individuals...... estimates of the income effect it is of interest to investigate the magnitude of the estimation bias and if possible use estimation techniques that take the measurement error problem into account. We use data from the Danish National Travel Survey (NTS) and merge it with administrative register data...... that contains very detailed information about incomes. This gives a unique opportunity to learn about the magnitude and nature of the measurement error in income reported by the respondents in the Danish NTS compared to income from the administrative register (correct measure). We find that the classical...

  1. Quark fragmentation function and the nonlinear chiral quark model

    International Nuclear Information System (INIS)

    Zhu, Z.K.

    1993-01-01

    The scaling law of the fragmentation function has been proved in this paper. With that, we show that low-P T quark fragmentation function can be studied as a low energy physocs in the light-cone coordinate frame. We therefore use the nonlinear chiral quark model which is able to study the low energy physics under scale Λ CSB to study such a function. Meanwhile the formalism for studying the quark fragmentation function has been established. The nonlinear chiral quark model is quantized on the light-front. We then use old-fashioned perturbation theory to study the quark fragmentation function. Our first order result for such a function shows in agreement with the phenomenological model study of e + e - jet. The probability for u,d pair formation in the e + e - jet from our calculation is also in agreement with the phenomenological model results

  2. Nonlinear model of high-dose implantation

    International Nuclear Information System (INIS)

    Danilyuk, A.

    2001-01-01

    The models of high-dose implantation, using the distribution functions, are relatively simple. However, they must take into account the variation of the function of distribution of the implanted ions with increasing dose [1-4]. This variation takes place owing to the fact that the increase of the concentration of the implanted ions results in a change of the properties of the target. High-dose implantation is accompanied by sputtering, volume growth, diffusion, generation of defects, formation of new phases, etc. The variation of the distribution function is determined by many factors and is not known in advance. The variation within the framework of these models [1-4] is taken into account in advance by the introduction of intuitive assumptions on the basis of implicit considerations. Therefore, these attempts should be regarded as incorrect. The model prepared here makes it possible to take into account the sputtering of the target, volume growth and additional declaration on the implanted ions. Without any assumptions in relation to the variation of the distribution function with increasing dose. In our model it is assumed that the type of distribution function for small doses in a pure target substance is the same as in substances with implanted ions. A second assumption relates to the type of the distribution function valid for small doses in the given substances. These functions are determined as a result of a large number of theoretical and experimental investigations and are well-known at the present time. They include the symmetric and nonsymmetric Gauss distribution, the Pearson distribution, and others. We examine implantation with small doses of up to 10 14 - 10 15 cm -2 when the accurately known distribution is valid

  3. Soliton excitations in a class of nonlinear field theory models

    International Nuclear Information System (INIS)

    Makhan'kov, V.G.; Fedyanin, V.K.

    1985-01-01

    Investigation results of nonlinear models of the field theory with a lagrangian are described. The theory includes models both with zero stable vacuum epsilon=1 and with condensate epsilon=-1 (of disturbed symmetry). Conditions of existence of particle-like solutions (PLS), stability of these solutions are investigated. Soliton dynamics is studied. PLS formfactors are calculated. Statistical mechanics of solitons is built and their dynamic structure factors are calculated

  4. The quantum nonlinear Schroedinger model with point-like defect

    International Nuclear Information System (INIS)

    Caudrelier, V; Mintchev, M; Ragoucy, E

    2004-01-01

    We establish a family of point-like impurities which preserve the quantum integrability of the nonlinear Schroedinger model in 1+1 spacetime dimensions. We briefly describe the construction of the exact second quantized solution of this model in terms of an appropriate reflection-transmission algebra. The basic physical properties of the solution, including the spacetime symmetry of the bulk scattering matrix, are also discussed. (letter to the editor)

  5. Eddy current modeling in linear and nonlinear multifilamentary composite materials

    Science.gov (United States)

    Menana, Hocine; Farhat, Mohamad; Hinaje, Melika; Berger, Kevin; Douine, Bruno; Lévêque, Jean

    2018-04-01

    In this work, a numerical model is developed for a rapid computation of eddy currents in composite materials, adaptable for both carbon fiber reinforced polymers (CFRPs) for NDT applications and multifilamentary high temperature superconductive (HTS) tapes for AC loss evaluation. The proposed model is based on an integro-differential formulation in terms of the electric vector potential in the frequency domain. The high anisotropy and the nonlinearity of the considered materials are easily handled in the frequency domain.

  6. Classical solutions for the 4-dimensional σ-nonlinear model

    International Nuclear Information System (INIS)

    Tataru-Mihai, P.

    1979-01-01

    By interpreting the σ-nonlinear model as describing the Gauss map associated to a certain immersion, several classes of classical solutions for the 4-dimensional model are derived. As by-products one points out i) an intimate connection between the energy-momentum tensor of the solution and the second differential form of the immersion associated to it and ii) a connection between self- (antiself-)duality of the solution and the minimality of the associated immersion. (author)

  7. Band mixing effects in mean field theories

    International Nuclear Information System (INIS)

    Kuyucak, S.; Morrison, I.

    1989-01-01

    The 1/N expansion method, which is an angular momentum projected mean field theory, is used to investigate the nature of electromagnetic transitions in the interacting boson model (IBM). Conversely, comparison with the exact IBM results sheds light on the range of validity of the mean field theory. It is shown that the projected mean field results for the E2 transitions among the ground, β and γ bands are incomplete for the spin dependent terms and it is essential to include band mixing effect for a correct (Mikhailov) analysis of E2 data. The algebraic expressions derived are general and will be useful in the analysis of experimental data in terms of both the sd and sdg boson models. 17 refs., 7 figs., 8 tabs

  8. Development of an Integrated Nonlinear Aeroservoelastic Flight Dynamic Model of the NASA Generic Transport Model

    Science.gov (United States)

    Nguyen, Nhan; Ting, Eric

    2018-01-01

    This paper describes a recent development of an integrated fully coupled aeroservoelastic flight dynamic model of the NASA Generic Transport Model (GTM). The integrated model couples nonlinear flight dynamics to a nonlinear aeroelastic model of the GTM. The nonlinearity includes the coupling of the rigid-body aircraft states in the partial derivatives of the aeroelastic angle of attack. Aeroservoelastic modeling of the control surfaces which are modeled by the Variable Camber Continuous Trailing Edge Flap is also conducted. The R.T. Jones' method is implemented to approximate unsteady aerodynamics. Simulations of the GTM are conducted with simulated continuous and discrete gust loads..

  9. Observing and modeling nonlinear dynamics in an internal combustion engine

    International Nuclear Information System (INIS)

    Daw, C.S.; Kennel, M.B.; Finney, C.E.; Connolly, F.T.

    1998-01-01

    We propose a low-dimensional, physically motivated, nonlinear map as a model for cyclic combustion variation in spark-ignited internal combustion engines. A key feature is the interaction between stochastic, small-scale fluctuations in engine parameters and nonlinear deterministic coupling between successive engine cycles. Residual cylinder gas from each cycle alters the in-cylinder fuel-air ratio and thus the combustion efficiency in succeeding cycles. The model close-quote s simplicity allows rapid simulation of thousands of engine cycles, permitting statistical studies of cyclic-variation patterns and providing physical insight into this technologically important phenomenon. Using symbol statistics to characterize the noisy dynamics, we find good quantitative matches between our model and experimental time-series measurements. copyright 1998 The American Physical Society

  10. Reduced Complexity Volterra Models for Nonlinear System Identification

    Directory of Open Access Journals (Sweden)

    Hacıoğlu Rıfat

    2001-01-01

    Full Text Available A broad class of nonlinear systems and filters can be modeled by the Volterra series representation. However, its practical use in nonlinear system identification is sometimes limited due to the large number of parameters associated with the Volterra filter′s structure. The parametric complexity also complicates design procedures based upon such a model. This limitation for system identification is addressed in this paper using a Fixed Pole Expansion Technique (FPET within the Volterra model structure. The FPET approach employs orthonormal basis functions derived from fixed (real or complex pole locations to expand the Volterra kernels and reduce the number of estimated parameters. That the performance of FPET can considerably reduce the number of estimated parameters is demonstrated by a digital satellite channel example in which we use the proposed method to identify the channel dynamics. Furthermore, a gradient-descent procedure that adaptively selects the pole locations in the FPET structure is developed in the paper.

  11. Nonlinear dynamics of avian influenza epidemic models.

    Science.gov (United States)

    Liu, Sanhong; Ruan, Shigui; Zhang, Xinan

    2017-01-01

    Avian influenza is a zoonotic disease caused by the transmission of the avian influenza A virus, such as H5N1 and H7N9, from birds to humans. The avian influenza A H5N1 virus has caused more than 500 human infections worldwide with nearly a 60% death rate since it was first reported in Hong Kong in 1997. The four outbreaks of the avian influenza A H7N9 in China from March 2013 to June 2016 have resulted in 580 human cases including 202 deaths with a death rate of nearly 35%. In this paper, we construct two avian influenza bird-to-human transmission models with different growth laws of the avian population, one with logistic growth and the other with Allee effect, and analyze their dynamical behavior. We obtain a threshold value for the prevalence of avian influenza and investigate the local or global asymptotical stability of each equilibrium of these systems by using linear analysis technique or combining Liapunov function method and LaSalle's invariance principle, respectively. Moreover, we give necessary and sufficient conditions for the occurrence of periodic solutions in the avian influenza system with Allee effect of the avian population. Numerical simulations are also presented to illustrate the theoretical results. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Multi-atom Jaynes-Cummings model with nonlinear effects

    International Nuclear Information System (INIS)

    Aleixo, Armando Nazareno Faria; Balantekin, Akif Baha; Ribeiro, Marco Antonio Candido

    2001-01-01

    The standard Jaynes-Cummings (JC) model and its extensions, normally used in quantum optics, idealizes the interaction of matter with electromagnetic radiation by a simple Hamiltonian of a two-level atom coupled to a single bosonic mode. This Hamiltonian has a fundamental importance to the field of quantum optics and it is a central ingredient in the quantized description of any optical system involving the interaction between light and atoms. The JC Hamiltonian defines a molecule, a composite system formed from the coupling of a two-state system and a quantized harmonic oscillator. For this Hamiltonian, mostly the single-particle situation has been studied. This model can also be extended for the situation where one has N two-level systems, which interact only with the electromagnetic radiation. In this case the effects of the spatial distribution of the particles it is not taken into account and the spin angular momentum S-circumflex i of each particle contributes to form a total angular momentum J-circumflex of the system. When one considers the effects due to the spatial variation in the field intensity in a nonlinear medium it is necessary to further add a Kerr term to the standard JC Hamiltonian. This kind of nonlinear JC Hamiltonian is used in the study of micro masers. Another nonlinear variant of the JC model takes the coupling between matter and the radiation to depend on the intensity of the electromagnetic field. This model is interesting since this kind of interaction means that effectively the coupling is proportional to the amplitude of the field representing a very simple case of a nonlinear interaction corresponding to a more realistic physical situation. In this work we solve exactly the problem of the interaction of a N two-level atoms with an electromagnetic radiation when nonlinear effects due to the spatial variation in the field intensity in a nonlinear Kerr medium and the dependence on the intensity of the electromagnetic field on the matter

  13. A data driven nonlinear stochastic model for blood glucose dynamics.

    Science.gov (United States)

    Zhang, Yan; Holt, Tim A; Khovanova, Natalia

    2016-03-01

    The development of adequate mathematical models for blood glucose dynamics may improve early diagnosis and control of diabetes mellitus (DM). We have developed a stochastic nonlinear second order differential equation to describe the response of blood glucose concentration to food intake using continuous glucose monitoring (CGM) data. A variational Bayesian learning scheme was applied to define the number and values of the system's parameters by iterative optimisation of free energy. The model has the minimal order and number of parameters to successfully describe blood glucose dynamics in people with and without DM. The model accounts for the nonlinearity and stochasticity of the underlying glucose-insulin dynamic process. Being data-driven, it takes full advantage of available CGM data and, at the same time, reflects the intrinsic characteristics of the glucose-insulin system without detailed knowledge of the physiological mechanisms. We have shown that the dynamics of some postprandial blood glucose excursions can be described by a reduced (linear) model, previously seen in the literature. A comprehensive analysis demonstrates that deterministic system parameters belong to different ranges for diabetes and controls. Implications for clinical practice are discussed. This is the first study introducing a continuous data-driven nonlinear stochastic model capable of describing both DM and non-DM profiles. Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

  14. Modal model for the nonlinear multimode Rayleigh endash Taylor instability

    International Nuclear Information System (INIS)

    Ofer, D.; Alon, U.; Shvarts, D.; McCrory, R.L.; Verdon, C.P.

    1996-01-01

    A modal model for the Rayleigh endash Taylor (RT) instability, applicable at all stages of the flow, is introduced. The model includes a description of nonlinear low-order mode coupling, mode growth saturation, and post-saturation mode coupling. It is shown to significantly extend the range of applicability of a previous model proposed by Haan, to cases where nonlinear mode generation is important. Using the new modal model, we study the relative importance of mode coupling at late nonlinear stages and resolve the difference between cases in which mode generation assumes a dominant role, leading to the late time inverse cascade of modes and loss of memory of initial conditions, and cases where mode generation is not important and memory of initial conditions is retained. Effects of finite density ratios (Atwood number A<1) are also included in the model and the difference between various measures of the mixing zone penetration depth for A<1 is discussed. copyright 1996 American Institute of Physics

  15. Nonlinear modeling of magnetorheological energy absorbers under impact conditions

    Science.gov (United States)

    Mao, Min; Hu, Wei; Choi, Young-Tai; Wereley, Norman M.; Browne, Alan L.; Ulicny, John; Johnson, Nancy

    2013-11-01

    Magnetorheological energy absorbers (MREAs) provide adaptive vibration and shock mitigation capabilities to accommodate varying payloads, vibration spectra, and shock pulses, as well as other environmental factors. A key performance metric is the dynamic range, which is defined as the ratio of the force at maximum field to the force in the absence of field. The off-state force is typically assumed to increase linearly with speed, but at the higher shaft speeds occurring in impact events, the off-state damping exhibits nonlinear velocity squared damping effects. To improve understanding of MREA behavior under high-speed impact conditions, this study focuses on nonlinear MREA models that can more accurately predict MREA dynamic behavior for nominal impact speeds of up to 6 m s-1. Three models were examined in this study. First, a nonlinear Bingham-plastic (BP) model incorporating Darcy friction and fluid inertia (Unsteady-BP) was formulated where the force is proportional to the velocity. Second, a Bingham-plastic model incorporating minor loss factors and fluid inertia (Unsteady-BPM) to better account for high-speed behavior was formulated. Third, a hydromechanical (HM) analysis was developed to account for fluid compressibility and inertia as well as minor loss factors. These models were validated using drop test data obtained using the drop tower facility at GM R&D Center for nominal drop speeds of up to 6 m s-1.

  16. Nonlinear modeling of magnetorheological energy absorbers under impact conditions

    International Nuclear Information System (INIS)

    Mao, Min; Hu, Wei; Choi, Young-Tai; Wereley, Norman M; Browne, Alan L; Ulicny, John; Johnson, Nancy

    2013-01-01

    Magnetorheological energy absorbers (MREAs) provide adaptive vibration and shock mitigation capabilities to accommodate varying payloads, vibration spectra, and shock pulses, as well as other environmental factors. A key performance metric is the dynamic range, which is defined as the ratio of the force at maximum field to the force in the absence of field. The off-state force is typically assumed to increase linearly with speed, but at the higher shaft speeds occurring in impact events, the off-state damping exhibits nonlinear velocity squared damping effects. To improve understanding of MREA behavior under high-speed impact conditions, this study focuses on nonlinear MREA models that can more accurately predict MREA dynamic behavior for nominal impact speeds of up to 6 m s −1 . Three models were examined in this study. First, a nonlinear Bingham-plastic (BP) model incorporating Darcy friction and fluid inertia (Unsteady-BP) was formulated where the force is proportional to the velocity. Second, a Bingham-plastic model incorporating minor loss factors and fluid inertia (Unsteady-BPM) to better account for high-speed behavior was formulated. Third, a hydromechanical (HM) analysis was developed to account for fluid compressibility and inertia as well as minor loss factors. These models were validated using drop test data obtained using the drop tower facility at GM R and D Center for nominal drop speeds of up to 6 m s −1 . (paper)

  17. Nonlinear unitary quantum collapse model with self-generated noise

    Science.gov (United States)

    Geszti, Tamás

    2018-04-01

    Collapse models including some external noise of unknown origin are routinely used to describe phenomena on the quantum-classical border; in particular, quantum measurement. Although containing nonlinear dynamics and thereby exposed to the possibility of superluminal signaling in individual events, such models are widely accepted on the basis of fully reproducing the non-signaling statistical predictions of quantum mechanics. Here we present a deterministic nonlinear model without any external noise, in which randomness—instead of being universally present—emerges in the measurement process, from deterministic irregular dynamics of the detectors. The treatment is based on a minimally nonlinear von Neumann equation for a Stern–Gerlach or Bell-type measuring setup, containing coordinate and momentum operators in a self-adjoint skew-symmetric, split scalar product structure over the configuration space. The microscopic states of the detectors act as a nonlocal set of hidden parameters, controlling individual outcomes. The model is shown to display pumping of weights between setup-defined basis states, with a single winner randomly selected and the rest collapsing to zero. Environmental decoherence has no role in the scenario. Through stochastic modelling, based on Pearle’s ‘gambler’s ruin’ scheme, outcome probabilities are shown to obey Born’s rule under a no-drift or ‘fair-game’ condition. This fully reproduces quantum statistical predictions, implying that the proposed non-linear deterministic model satisfies the non-signaling requirement. Our treatment is still vulnerable to hidden signaling in individual events, which remains to be handled by future research.

  18. Non-linear sigma model on the fuzzy supersphere

    International Nuclear Information System (INIS)

    Kurkcuoglu, Seckin

    2004-01-01

    In this note we develop fuzzy versions of the supersymmetric non-linear sigma model on the supersphere S (2,2) . In hep-th/0212133 Bott projectors have been used to obtain the fuzzy C P 1 model. Our approach utilizes the use of supersymmetric extensions of these projectors. Here we obtain these (super)-projectors and quantize them in a fashion similar to the one given in hep-th/0212133. We discuss the interpretation of the resulting model as a finite dimensional matrix model. (author)

  19. Cardiovascular oscillations: in search of a nonlinear parametric model

    Science.gov (United States)

    Bandrivskyy, Andriy; Luchinsky, Dmitry; McClintock, Peter V.; Smelyanskiy, Vadim; Stefanovska, Aneta; Timucin, Dogan

    2003-05-01

    We suggest a fresh approach to the modeling of the human cardiovascular system. Taking advantage of a new Bayesian inference technique, able to deal with stochastic nonlinear systems, we show that one can estimate parameters for models of the cardiovascular system directly from measured time series. We present preliminary results of inference of parameters of a model of coupled oscillators from measured cardiovascular data addressing cardiorespiratory interaction. We argue that the inference technique offers a very promising tool for the modeling, able to contribute significantly towards the solution of a long standing challenge -- development of new diagnostic techniques based on noninvasive measurements.

  20. Spatio-temporal modeling of nonlinear distributed parameter systems

    CERN Document Server

    Li, Han-Xiong

    2011-01-01

    The purpose of this volume is to provide a brief review of the previous work on model reduction and identifi cation of distributed parameter systems (DPS), and develop new spatio-temporal models and their relevant identifi cation approaches. In this book, a systematic overview and classifi cation on the modeling of DPS is presented fi rst, which includes model reduction, parameter estimation and system identifi cation. Next, a class of block-oriented nonlinear systems in traditional lumped parameter systems (LPS) is extended to DPS, which results in the spatio-temporal Wiener and Hammerstein s

  1. Estimation of Nonlinear DC-Motor Models Using a Sensitivity Approach

    DEFF Research Database (Denmark)

    Knudsen, Morten; Jensen, J.G.

    1995-01-01

    A nonlinear model structure for a permanent magnet DC-motor, appropriate for simulation and controller design, is developed.......A nonlinear model structure for a permanent magnet DC-motor, appropriate for simulation and controller design, is developed....

  2. Linear theory for filtering nonlinear multiscale systems with model error.

    Science.gov (United States)

    Berry, Tyrus; Harlim, John

    2014-07-08

    In this paper, we study filtering of multiscale dynamical systems with model error arising from limitations in resolving the smaller scale processes. In particular, the analysis assumes the availability of continuous-time noisy observations of all components of the slow variables. Mathematically, this paper presents new results on higher order asymptotic expansion of the first two moments of a conditional measure. In particular, we are interested in the application of filtering multiscale problems in which the conditional distribution is defined over the slow variables, given noisy observation of the slow variables alone. From the mathematical analysis, we learn that for a continuous time linear model with Gaussian noise, there exists a unique choice of parameters in a linear reduced model for the slow variables which gives the optimal filtering when only the slow variables are observed. Moreover, these parameters simultaneously give the optimal equilibrium statistical estimates of the underlying system, and as a consequence they can be estimated offline from the equilibrium statistics of the true signal. By examining a nonlinear test model, we show that the linear theory extends in this non-Gaussian, nonlinear configuration as long as we know the optimal stochastic parametrization and the correct observation model. However, when the stochastic parametrization model is inappropriate, parameters chosen for good filter performance may give poor equilibrium statistical estimates and vice versa; this finding is based on analytical and numerical results on our nonlinear test model and the two-layer Lorenz-96 model. Finally, even when the correct stochastic ansatz is given, it is imperative to estimate the parameters simultaneously and to account for the nonlinear feedback of the stochastic parameters into the reduced filter estimates. In numerical experiments on the two-layer Lorenz-96 model, we find that the parameters estimated online , as part of a filtering

  3. A non-linear model of economic production processes

    Science.gov (United States)

    Ponzi, A.; Yasutomi, A.; Kaneko, K.

    2003-06-01

    We present a new two phase model of economic production processes which is a non-linear dynamical version of von Neumann's neoclassical model of production, including a market price-setting phase as well as a production phase. The rate of an economic production process is observed, for the first time, to depend on the minimum of its input supplies. This creates highly non-linear supply and demand dynamics. By numerical simulation, production networks are shown to become unstable when the ratio of different products to total processes increases. This provides some insight into observed stability of competitive capitalist economies in comparison to monopolistic economies. Capitalist economies are also shown to have low unemployment.

  4. Nonlinear Economic Model Predictive Control Strategy for Active Smart Buildings

    DEFF Research Database (Denmark)

    Santos, Rui Mirra; Zong, Yi; Sousa, Joao M. C.

    2016-01-01

    Nowadays, the development of advanced and innovative intelligent control techniques for energy management in buildings is a key issue within the smart grid topic. A nonlinear economic model predictive control (EMPC) scheme, based on the branch-and-bound tree search used as optimization algorithm ...... controller is shown very reliable keeping the comfort levels in the two considered seasons and shifting the load away from peak hours in order to achieve the desired flexible electricity consumption.......Nowadays, the development of advanced and innovative intelligent control techniques for energy management in buildings is a key issue within the smart grid topic. A nonlinear economic model predictive control (EMPC) scheme, based on the branch-and-bound tree search used as optimization algorithm...

  5. Non-linear calibration models for near infrared spectroscopy

    DEFF Research Database (Denmark)

    Ni, Wangdong; Nørgaard, Lars; Mørup, Morten

    2014-01-01

    by ridge regression (RR). The performance of the different methods is demonstrated by their practical applications using three real-life near infrared (NIR) data sets. Different aspects of the various approaches including computational time, model interpretability, potential over-fitting using the non-linear...... models on linear problems, robustness to small or medium sample sets, and robustness to pre-processing, are discussed. The results suggest that GPR and BANN are powerful and promising methods for handling linear as well as nonlinear systems, even when the data sets are moderately small. The LS......-SVM), relevance vector machines (RVM), Gaussian process regression (GPR), artificial neural network (ANN), and Bayesian ANN (BANN). In this comparison, partial least squares (PLS) regression is used as a linear benchmark, while the relationship of the methods is considered in terms of traditional calibration...

  6. Comparing Numerical Spall Simulations with a Nonlinear Spall Formation Model

    Science.gov (United States)

    Ong, L.; Melosh, H. J.

    2012-12-01

    Spallation accelerates lightly shocked ejecta fragments to speeds that can exceed the escape velocity of the parent body. We present high-resolution simulations of nonlinear shock interactions in the near surface. Initial results show the acceleration of near-surface material to velocities up to 1.8 times greater than the peak particle velocity in the detached shock, while experiencing little to no shock pressure. These simulations suggest a possible nonlinear spallation mechanism to produce the high-velocity, low show pressure meteorites from other planets. Here we pre-sent the numerical simulations that test the production of spall through nonlinear shock interactions in the near sur-face, and compare the results with a model proposed by Kamegai (1986 Lawrence Livermore National Laboratory Report). We simulate near-surface shock interactions using the SALES_2 hydrocode and the Murnaghan equation of state. We model the shock interactions in two geometries: rectangular and spherical. In the rectangular case, we model a planar shock approaching the surface at a constant angle phi. In the spherical case, the shock originates at a point below the surface of the domain and radiates spherically from that point. The angle of the shock front with the surface is dependent on the radial distance of the surface point from the shock origin. We model the target as a solid with a nonlinear Murnaghan equation of state. This idealized equation of state supports nonlinear shocks but is tem-perature independent. We track the maximum pressure and maximum velocity attained in every cell in our simula-tions and compare them to the Hugoniot equations that describe the material conditions in front of and behind the shock. Our simulations demonstrate that nonlinear shock interactions in the near surface produce lightly shocked high-velocity material for both planar and cylindrical shocks. The spall is the result of the free surface boundary condi-tion, which forces a pressure gradient

  7. Ward Identity and Scattering Amplitudes for Nonlinear Sigma Models

    Science.gov (United States)

    Low, Ian; Yin, Zhewei

    2018-02-01

    We present a Ward identity for nonlinear sigma models using generalized nonlinear shift symmetries, without introducing current algebra or coset space. The Ward identity constrains correlation functions of the sigma model such that the Adler's zero is guaranteed for S -matrix elements, and gives rise to a subleading single soft theorem that is valid at the quantum level and to all orders in the Goldstone decay constant. For tree amplitudes, the Ward identity leads to a novel Berends-Giele recursion relation as well as an explicit form of the subleading single soft factor. Furthermore, interactions of the cubic biadjoint scalar theory associated with the single soft limit, which was previously discovered using the Cachazo-He-Yuan representation of tree amplitudes, can be seen to emerge from matrix elements of conserved currents corresponding to the generalized shift symmetry.

  8. NON-LINEAR FINITE ELEMENT MODELING OF DEEP DRAWING PROCESS

    Directory of Open Access Journals (Sweden)

    Hasan YILDIZ

    2004-03-01

    Full Text Available Deep drawing process is one of the main procedures used in different branches of industry. Finding numerical solutions for determination of the mechanical behaviour of this process will save time and money. In die surfaces, which have complex geometries, it is hard to determine the effects of parameters of sheet metal forming. Some of these parameters are wrinkling, tearing, and determination of the flow of the thin sheet metal in the die and thickness change. However, the most difficult one is determination of material properties during plastic deformation. In this study, the effects of all these parameters are analyzed before producing the dies. The explicit non-linear finite element method is chosen to be used in the analysis. The numerical results obtained for non-linear material and contact models are also compared with the experiments. A good agreement between the numerical and the experimental results is obtained. The results obtained for the models are given in detail.

  9. Nonlinear dynamics mathematical models for rigid bodies with a liquid

    CERN Document Server

    Lukovsky, Ivan A

    2015-01-01

    This book is devoted to analytically approximate methods in the nonlinear dynamics of a rigid body with cavities partly filled by liquid. It combines several methods and compares the results with experimental data. It is useful for experienced and early-stage readers interested in analytical approaches to fluid-structure interaction problems, the fundamental mathematical background and modeling the dynamics of such complex mechanical systems.

  10. Nonlinear Stochastic Models for Water Level Dynamics in Closed Lakes

    OpenAIRE

    Mishchenko, A.S.; Zelikin, M.I.; Zelikina, L.F.

    1995-01-01

    This paper presents the results of investigation of nonlinear mathematical models of the behavior of closed lakes using the example of the Caspian Sea. Forecasting the level of the Caspian Sea is crucial both for the economy of the region and for the region's environment. The Caspian Sea is a closed reservoir; it is well known that its level changes considerably due to a variety of factors including global climate change. A series of forecasts exists based on different methods and taking...

  11. NON-LINEAR MODELING OF THE RHIC INTERACTION REGIONS

    International Nuclear Information System (INIS)

    TOMAS, R.; FISCHER, W.; JAIN, A.; LUO, Y.; PILAT, F.

    2004-01-01

    For RHIC's collision lattices the dominant sources of transverse non-linearities are located in the interaction regions. The field quality is available for most of the magnets in the interaction regions from the magnetic measurements, or from extrapolations of these measurements. We discuss the implementation of these measurements in the MADX models of the Blue and the Yellow rings and their impact on beam stability

  12. Nonlinear evolution inclusions arising from phase change models

    Czech Academy of Sciences Publication Activity Database

    Colli, P.; Krejčí, Pavel; Rocca, E.; Sprekels, J.

    2007-01-01

    Roč. 57, č. 4 (2007), s. 1067-1098 ISSN 0011-4642 R&D Projects: GA ČR GA201/02/1058 Institutional research plan: CEZ:AV0Z10190503 Keywords : nonlinear and nonlocal evolution equations * Cahn-Hilliard type dynamics * phase transitions models Subject RIV: BA - General Mathematics Impact factor: 0.155, year: 2007 http://www.dml.cz/bitstream/handle/10338.dmlcz/128228/CzechMathJ_57-2007-4_2.pdf

  13. Nonlinear Model Predictive Control for Cooperative Control and Estimation

    Science.gov (United States)

    Ru, Pengkai

    Recent advances in computational power have made it possible to do expensive online computations for control systems. It is becoming more realistic to perform computationally intensive optimization schemes online on systems that are not intrinsically stable and/or have very small time constants. Being one of the most important optimization based control approaches, model predictive control (MPC) has attracted a lot of interest from the research community due to its natural ability to incorporate constraints into its control formulation. Linear MPC has been well researched and its stability can be guaranteed in the majority of its application scenarios. However, one issue that still remains with linear MPC is that it completely ignores the system's inherent nonlinearities thus giving a sub-optimal solution. On the other hand, if achievable, nonlinear MPC, would naturally yield a globally optimal solution and take into account all the innate nonlinear characteristics. While an exact solution to a nonlinear MPC problem remains extremely computationally intensive, if not impossible, one might wonder if there is a middle ground between the two. We tried to strike a balance in this dissertation by employing a state representation technique, namely, the state dependent coefficient (SDC) representation. This new technique would render an improved performance in terms of optimality compared to linear MPC while still keeping the problem tractable. In fact, the computational power required is bounded only by a constant factor of the completely linearized MPC. The purpose of this research is to provide a theoretical framework for the design of a specific kind of nonlinear MPC controller and its extension into a general cooperative scheme. The controller is designed and implemented on quadcopter systems.

  14. Nonlinear joint models for individual dynamic prediction of risk of death using Hamiltonian Monte Carlo: application to metastatic prostate cancer

    Directory of Open Access Journals (Sweden)

    Solène Desmée

    2017-07-01

    Full Text Available Abstract Background Joint models of longitudinal and time-to-event data are increasingly used to perform individual dynamic prediction of a risk of event. However the difficulty to perform inference in nonlinear models and to calculate the distribution of individual parameters has long limited this approach to linear mixed-effect models for the longitudinal part. Here we use a Bayesian algorithm and a nonlinear joint model to calculate individual dynamic predictions. We apply this approach to predict the risk of death in metastatic castration-resistant prostate cancer (mCRPC patients with frequent Prostate-Specific Antigen (PSA measurements. Methods A joint model is built using a large population of 400 mCRPC patients where PSA kinetics is described by a biexponential function and the hazard function is a PSA-dependent function. Using Hamiltonian Monte Carlo algorithm implemented in Stan software and the estimated population parameters in this population as priors, the a posteriori distribution of the hazard function is computed for a new patient knowing his PSA measurements until a given landmark time. Time-dependent area under the ROC curve (AUC and Brier score are derived to assess discrimination and calibration of the model predictions, first on 200 simulated patients and then on 196 real patients that are not included to build the model. Results Satisfying coverage probabilities of Monte Carlo prediction intervals are obtained for longitudinal and hazard functions. Individual dynamic predictions provide good predictive performances for landmark times larger than 12 months and horizon time of up to 18 months for both simulated and real data. Conclusions As nonlinear joint models can characterize the kinetics of biomarkers and their link with a time-to-event, this approach could be useful to improve patient’s follow-up and the early detection of most at risk patients.

  15. Parameter Estimation and Prediction of a Nonlinear Storage Model: an algebraic approach

    NARCIS (Netherlands)

    Doeswijk, T.G.; Keesman, K.J.

    2005-01-01

    Generally, parameters that are nonlinear in system models are estimated by nonlinear least-squares optimization algorithms. In this paper, if a nonlinear discrete-time model with a polynomial quotient structure in input, output, and parameters, a method is proposed to re-parameterize the model such

  16. Reduced-order modelling of parameter-dependent, linear and nonlinear dynamic partial differential equation models.

    Science.gov (United States)

    Shah, A A; Xing, W W; Triantafyllidis, V

    2017-04-01

    In this paper, we develop reduced-order models for dynamic, parameter-dependent, linear and nonlinear partial differential equations using proper orthogonal decomposition (POD). The main challenges are to accurately and efficiently approximate the POD bases for new parameter values and, in the case of nonlinear problems, to efficiently handle the nonlinear terms. We use a Bayesian nonlinear regression approach to learn the snapshots of the solutions and the nonlinearities for new parameter values. Computational efficiency is ensured by using manifold learning to perform the emulation in a low-dimensional space. The accuracy of the method is demonstrated on a linear and a nonlinear example, with comparisons with a global basis approach.

  17. Use of nonlinear dose-effect models to predict consequences

    International Nuclear Information System (INIS)

    Seiler, F.A.; Alvarez, J.L.

    1996-01-01

    The linear dose-effect relationship was introduced as a model for the induction of cancer from exposure to nuclear radiation. Subsequently, it has been used by analogy to assess the risk of chemical carcinogens also. Recently, however, the model for radiation carcinogenesis has come increasingly under attack because its calculations contradict the epidemiological data, such as cancer in atomic bomb survivors. Even so, its proponents vigorously defend it, often using arguments that are not so much scientific as a mix of scientific, societal, and often political arguments. At least in part, the resilience of the linear model is due to two convenient properties that are exclusive to linearity: First, the risk of an event is determined solely by the event dose; second, the total risk of a population group depends only on the total population dose. In reality, the linear model has been conclusively falsified; i.e., it has been shown to make wrong predictions, and once this fact is generally realized, the scientific method calls for a new paradigm model. As all alternative models are by necessity nonlinear, all the convenient properties of the linear model are invalid, and calculational procedures have to be used that are appropriate for nonlinear models

  18. Landau fluid model for weakly nonlinear dispersive magnetohydrodynamics

    International Nuclear Information System (INIS)

    Passot, T.; Sulem, P. L.

    2005-01-01

    In may astrophysical plasmas such as the solar wind, the terrestrial magnetosphere, or in the interstellar medium at small enough scales, collisions are negligible. When interested in the large-scale dynamics, a hydrodynamic approach is advantageous not only because its numerical simulations is easier than of the full Vlasov-Maxwell equations, but also because it provides a deep understanding of cross-scale nonlinear couplings. It is thus of great interest to construct fluid models that extended the classical magnetohydrodynamic (MHD) equations to collisionless situations. Two ingredients need to be included in such a model to capture the main kinetic effects: finite Larmor radius (FLR) corrections and Landau damping, the only fluid-particle resonance that can affect large scales and can be modeled in a relatively simple way. The Modelization of Landau damping in a fluid formalism is hardly possible in the framework of a systematic asymptotic expansion and was addressed mainly by means of parameter fitting in a linearized setting. We introduced a similar Landau fluid model but, that has the advantage of taking dispersive effects into account. This model properly describes dispersive MHD waves in quasi-parallel propagation. Since, by construction, the system correctly reproduces their linear dynamics, appropriate tests should address the nonlinear regime. In a first case, we show analytically that the weakly nonlinear modulational dynamics of quasi-parallel propagating Alfven waves is well captured. As a second test we consider the parametric decay instability of parallel Alfven waves and show that numerical simulations of the dispersive Landau fluid model lead to results that closely match the outcome of hybrid simulations. (Author)

  19. The inherent complexity in nonlinear business cycle model in resonance

    International Nuclear Information System (INIS)

    Ma Junhai; Sun Tao; Liu Lixia

    2008-01-01

    Based on Abraham C.-L. Chian's research, we applied nonlinear dynamic system theory to study the first-order and second-order approximate solutions to one category of the nonlinear business cycle model in resonance condition. We have also analyzed the relation between amplitude and phase of second-order approximate solutions as well as the relation between outer excitements' amplitude, frequency approximate solutions, and system bifurcation parameters. Then we studied the system quasi-periodical solutions, annulus periodical solutions and the path leading to system bifurcation and chaotic state with different parameter combinations. Finally, we conducted some numerical simulations for various complicated circumstances. Therefore this research will lay solid foundation for detecting the complexity of business cycles and systems in the future

  20. Testing and inference in nonlinear cointegrating vector error correction models

    DEFF Research Database (Denmark)

    Kristensen, D.; Rahbek, A.

    2013-01-01

    We analyze estimators and tests for a general class of vector error correction models that allows for asymmetric and nonlinear error correction. For a given number of cointegration relationships, general hypothesis testing is considered, where testing for linearity is of particular interest. Under...... the null of linearity, parameters of nonlinear components vanish, leading to a nonstandard testing problem. We apply so-called sup-tests to resolve this issue, which requires development of new(uniform) functional central limit theory and results for convergence of stochastic integrals. We provide a full...... asymptotic theory for estimators and test statistics. The derived asymptotic results prove to be nonstandard compared to results found elsewhere in the literature due to the impact of the estimated cointegration relations. This complicates implementation of tests motivating the introduction of bootstrap...

  1. Application of nonlinear forecasting techniques for meteorological modeling

    Directory of Open Access Journals (Sweden)

    V. Pérez-Muñuzuri

    2000-10-01

    Full Text Available A nonlinear forecasting method was used to predict the behavior of a cloud coverage time series several hours in advance. The method is based on the reconstruction of a chaotic strange attractor using four years of cloud absorption data obtained from half-hourly Meteosat infrared images from Northwestern Spain. An exhaustive nonlinear analysis of the time series was carried out to reconstruct the phase space of the underlying chaotic attractor. The forecast values are used by a non-hydrostatic meteorological model ARPS for daily weather prediction and their results compared with surface temperature measurements from a meteorological station and a vertical sounding. The effect of noise in the time series is analyzed in terms of the prediction results.Key words: Meterology and atmospheric dynamics (mesoscale meteorology; general – General (new fields

  2. Application of nonlinear forecasting techniques for meteorological modeling

    Directory of Open Access Journals (Sweden)

    V. Pérez-Muñuzuri

    Full Text Available A nonlinear forecasting method was used to predict the behavior of a cloud coverage time series several hours in advance. The method is based on the reconstruction of a chaotic strange attractor using four years of cloud absorption data obtained from half-hourly Meteosat infrared images from Northwestern Spain. An exhaustive nonlinear analysis of the time series was carried out to reconstruct the phase space of the underlying chaotic attractor. The forecast values are used by a non-hydrostatic meteorological model ARPS for daily weather prediction and their results compared with surface temperature measurements from a meteorological station and a vertical sounding. The effect of noise in the time series is analyzed in terms of the prediction results.

    Key words: Meterology and atmospheric dynamics (mesoscale meteorology; general – General (new fields

  3. Nonlinear dynamical modeling and prediction of the terrestrial magnetospheric activity

    International Nuclear Information System (INIS)

    Vassiliadis, D.

    1992-01-01

    The irregular activity of the magnetosphere results from its complex internal dynamics as well as the external influence of the solar wind. The dominating self-organization of the magnetospheric plasma gives rise to repetitive, large-scale coherent behavior manifested in phenomena such as the magnetic substorm. Based on the nonlinearity of the global dynamics this dissertation examines the magnetosphere as a nonlinear dynamical system using time series analysis techniques. Initially the magnetospheric activity is modeled in terms of an autonomous system. A dimension study shows that its observed time series is self-similar, but the correlation dimension is high. The implication of a large number of degrees of freedom is confirmed by other state space techniques such as Poincare sections and search for unstable periodic orbits. At the same time a stability study of the time series in terms of Lyapunov exponents suggests that the series is not chaotic. The absence of deterministic chaos is supported by the low predictive capability of the autonomous model. Rather than chaos, it is an external input which is largely responsible for the irregularity of the magnetospheric activity. In fact, the external driving is so strong that the above state space techniques give results for magnetospheric and solar wind time series that are at least qualitatively similar. Therefore the solar wind input has to be included in a low-dimensional nonautonomous model. Indeed it is shown that such a model can reproduce the observed magnetospheric behavior up to 80-90 percent. The characteristic coefficients of the model show little variation depending on the external disturbance. The impulse response is consistent with earlier results of linear prediction filters. The model can be easily extended to contain nonlinear features of the magnetospheric activity and in particular the loading-unloading behavior of substorms

  4. Comparison of a nonlinear dynamic model of a piping system to test data

    International Nuclear Information System (INIS)

    Blakely, K.D.; Howard, G.E.; Walton, W.B.; Johnson, B.A.; Chitty, D.E.

    1983-01-01

    Response of a nonlinear finite element model of the Heissdampfreaktor recirculation piping loop (URL) was compared to measured data, representing the physical benchmarking of a nonlinear model. Analysis-test comparisons of piping response are presented for snapback tests that induced extreme nonlinear behavior of the URL system. Nonlinearities in the system are due to twelve swaybraces (pipe supports) that possessed nonlinear force-deflection characteristics. These nonlinearities distorted system damping estimates made by using the half-power bandwidth method on Fourier transforms of measured accelerations, with the severity of distortion increasing with increasing degree of nonlinearity. Time domain methods, which are not so severely affected by the presence of nonlinearities, were used to compute system damping ratios. Nonlinear dynamic analyses were accurately and efficiently performed using the pseudo-force technique and the finite element program MSC/NASTRAN. Measured damping was incorporated into the model for snapback simulations. Acceleration time histories, acceleration Fourier transforms, and swaybrace force time histories of the nonlinear model, plus several linear models, were compared to test measurements. The nonlinear model predicted three-fourths of the measured peak accelerations to within 50%, half of the accelerations to within 25%, and one-fifth of the accelerations to within 10%. This nonlinear model predicted accelerations (in the time and frequency domains) and swaybrace forces much better than did any of the linear models, demonstrating the increased accuracy resulting from properly simulating nonlinear support behavior. In addition, earthquake response comparisons were made between the experimentally validated nonlinear model and a linear model. Significantly lower element stresses were predicted for the nonlinear model, indicating the potential usefulness of nonlinear simulations in piping design assessments. (orig.)

  5. Nonlinear Model Predictive Control for Solid Oxide Fuel Cell System Based On Wiener Model

    OpenAIRE

    T. H. Lee; J. H. Park; S. M. Lee; S. C. Lee

    2010-01-01

    In this paper, we consider Wiener nonlinear model for solid oxide fuel cell (SOFC). The Wiener model of the SOFC consists of a linear dynamic block and a static output non-linearity followed by the block, in which linear part is approximated by state-space model and the nonlinear part is identified by a polynomial form. To control the SOFC system, we have to consider various view points such as operating conditions, another constraint conditions, change of load current and so on. A change of ...

  6. An SIRS model with a nonlinear incidence rate

    International Nuclear Information System (INIS)

    Jin Yu; Wang, Wendi; Xiao Shiwu

    2007-01-01

    The global dynamics of an SIRS model with a nonlinear incidence rate is investigated. We establish a threshold for a disease to be extinct or endemic, analyze the existence and asymptotic stability of equilibria, and verify the existence of bistable states, i.e., a stable disease free equilibrium and a stable endemic equilibrium or a stable limit cycle. In particular, we find that the model admits stability switches as a parameter changes. We also investigate the backward bifurcation, the Hopf bifurcation and Bogdanov-Takens bifurcation and obtain the Hopf bifurcation criteria and Bogdanov-Takens bifurcation curves, which are important for making strategies for controlling a disease

  7. Stability Analysis of Some Nonlinear Anaerobic Digestion Models

    Directory of Open Access Journals (Sweden)

    Ivan Simeonov

    2010-04-01

    Full Text Available Abstract: The paper deals with local asymptotic stability analysis of some mass balance dynamic models (based on one and on two-stage reaction schemes of the anaerobic digestion (AD in CSTR. The equilibrium states for models based on one (with Monod, Contois and Haldane shapes for the specific growth rate and on two-stage (only with Monod shapes for both the specific growth rate of acidogenic and methanogenic bacterial populations reaction schemes have been determined solving sets of nonlinear algebraic equations using Maples. Their stability has been analyzed systematically, which provides insight and guidance for AD bioreactors design, operation and control.

  8. The Precession Index and a Nonlinear Energy Balance Climate Model

    Science.gov (United States)

    Rubincam, David

    2004-01-01

    A simple nonlinear energy balance climate model yields a precession index-like term in the temperature. Despite its importance in the geologic record, the precession index e sin (Omega)S, where e is the Earth's orbital eccentricity and (Omega)S is the Sun's perigee in the geocentric frame, is not present in the insolation at the top of the atmosphere. Hence there is no one-for-one mapping of 23,000 and 19,000 year periodicities from the insolation to the paleoclimate record; a nonlinear climate model is needed to produce these long periods. A nonlinear energy balance climate model with radiative terms of form T n, where T is surface temperature and n less than 1, does produce e sin (omega)S terms in temperature; the e sin (omega)S terms are called Seversmith psychroterms. Without feedback mechanisms, the model achieves extreme values of 0.64 K at the maximum orbital eccentricity of 0.06, cooling one hemisphere while simultaneously warming the other; the hemisphere over which perihelion occurs is the cooler. In other words, the nonlinear energy balance model produces long-term cooling in the northern hemisphere when the Sun's perihelion is near northern summer solstice and long-term warming in the northern hemisphere when the aphelion is near northern summer solstice. (This behavior is similar to the inertialess gray body which radiates like T 4, but the amplitude is much lower for the energy balance model because of its thermal inertia.) This seemingly paradoxical behavior works against the standard Milankovitch model, which requires cool northern summers (Sun far from Earth in northern summer) to build up northern ice sheets, so that if the standard model is correct it must be more efficient than previously thought. Alternatively, the new mechanism could possibly be dominant and indicate southern hemisphere control of the northern ice sheets, wherein the southern oceans undergo a long-term cooling when the Sun is far from the Earth during northern summer. The cold

  9. A nonlinear model for ionic polymer metal composites as actuators

    Science.gov (United States)

    Bonomo, C.; Fortuna, L.; Giannone, P.; Graziani, S.; Strazzeri, S.

    2007-02-01

    This paper introduces a comprehensive nonlinear dynamic model of motion actuators based on ionic polymer metal composites (IPMCs) working in air. Significant quantities ruling the acting properties of IPMC-based actuators are taken into account. The model is organized as follows. As a first step, the dependence of the IPMC absorbed current on the voltage applied across its thickness is taken into account; a nonlinear circuit model is proposed to describe this relationship. In a second step the transduction of the absorbed current into the IPMC mechanical reaction is modelled. The model resulting from the cascade of both the electrical and the electromechanical stages represents a novel contribution in the field of IPMCs, capable of describing the electromechanical behaviour of these materials and predicting relevant quantities in a large range of applied signals. The effect of actuator scaling is also investigated, giving interesting support to the activities involved in the design of actuating devices based on these novel materials. Evidence of the excellent agreement between the estimations obtained by using the proposed model and experimental signals is given.

  10. Augmented twin-nonlinear two-box behavioral models for multicarrier LTE power amplifiers.

    Science.gov (United States)

    Hammi, Oualid

    2014-01-01

    A novel class of behavioral models is proposed for LTE-driven Doherty power amplifiers with strong memory effects. The proposed models, labeled augmented twin-nonlinear two-box models, are built by cascading a highly nonlinear memoryless function with a mildly nonlinear memory polynomial with cross terms. Experimental validation on gallium nitride based Doherty power amplifiers illustrates the accuracy enhancement and complexity reduction achieved by the proposed models. When strong memory effects are observed, the augmented twin-nonlinear two-box models can improve the normalized mean square error by up to 3 dB for the same number of coefficients when compared to state-of-the-art twin-nonlinear two-box models. Furthermore, the augmented twin-nonlinear two-box models lead to the same performance as previously reported twin-nonlinear two-box models while requiring up to 80% less coefficients.

  11. Pharmacokinetic/Pharmacodynamic Modelling of GnRH Antagonist Degarelix: A Comparison of the Non-linear Mixed-Effects Programs NONMEM and NLME

    DEFF Research Database (Denmark)

    Tornøe, Christoffer Wenzel; Agersø, Henrik; Nielsen, Henrik Aalborg

    2004-01-01

    proposed by Lindstrom and Bates. The two programs were tested using clinical PK/PD data of a new gonadotropin-releasing hormone (GnRH) antagonist degarelix currently being developed for prostate cancer treatment. The pharmacokinetics of intravenous administered degarelix was analysed using a three...

  12. A non-linear state space approach to model groundwater fluctuations

    NARCIS (Netherlands)

    Berendrecht, W.L.; Heemink, A.W.; Geer, F.C. van; Gehrels, J.C.

    2006-01-01

    A non-linear state space model is developed for describing groundwater fluctuations. Non-linearity is introduced by modeling the (unobserved) degree of water saturation of the root zone. The non-linear relations are based on physical concepts describing the dependence of both the actual

  13. Frequency Response of Synthetic Vocal Fold Models with Linear and Nonlinear Material Properties

    Science.gov (United States)

    Shaw, Stephanie M.; Thomson, Scott L.; Dromey, Christopher; Smith, Simeon

    2012-01-01

    Purpose: The purpose of this study was to create synthetic vocal fold models with nonlinear stress-strain properties and to investigate the effect of linear versus nonlinear material properties on fundamental frequency (F[subscript 0]) during anterior-posterior stretching. Method: Three materially linear and 3 materially nonlinear models were…

  14. A nonlinear inversion for the velocity background and perturbation models

    KAUST Repository

    Wu, Zedong

    2015-08-19

    Reflected waveform inversion (RWI) provides a method to reduce the nonlinearity of the standard full waveform inversion (FWI) by inverting for the single scattered wavefield obtained using an image. However, current RWI methods usually neglect diving waves, which is an important source of information for extracting the long wavelength components of the velocity model. Thus, we propose a new optimization problem through breaking the velocity model into the background and the perturbation in the wave equation directly. In this case, the perturbed model is no longer the single scattering model, but includes all scattering. We optimize both components simultaneously, and thus, the objective function is nonlinear with respect to both the background and perturbation. The new introduced w can absorb the non-smooth update of background naturally. Application to the Marmousi model with frequencies that start at 5 Hz shows that this method can converge to the accurate velocity starting from a linearly increasing initial velocity. Application to the SEG2014 demonstrates the versatility of the approach.

  15. A penalized framework for distributed lag non-linear models.

    Science.gov (United States)

    Gasparrini, Antonio; Scheipl, Fabian; Armstrong, Ben; Kenward, Michael G

    2017-09-01

    Distributed lag non-linear models (DLNMs) are a modelling tool for describing potentially non-linear and delayed dependencies. Here, we illustrate an extension of the DLNM framework through the use of penalized splines within generalized additive models (GAM). This extension offers built-in model selection procedures and the possibility of accommodating assumptions on the shape of the lag structure through specific penalties. In addition, this framework includes, as special cases, simpler models previously proposed for linear relationships (DLMs). Alternative versions of penalized DLNMs are compared with each other and with the standard unpenalized version in a simulation study. Results show that this penalized extension to the DLNM class provides greater flexibility and improved inferential properties. The framework exploits recent theoretical developments of GAMs and is implemented using efficient routines within freely available software. Real-data applications are illustrated through two reproducible examples in time series and survival analysis. © 2017 The Authors Biometrics published by Wiley Periodicals, Inc. on behalf of International Biometric Society.

  16. Controlled Nonlinear Stochastic Delay Equations: Part I: Modeling and Approximations

    International Nuclear Information System (INIS)

    Kushner, Harold J.

    2012-01-01

    This two-part paper deals with “foundational” issues that have not been previously considered in the modeling and numerical optimization of nonlinear stochastic delay systems. There are new classes of models, such as those with nonlinear functions of several controls (such as products), each with is own delay, controlled random Poisson measure driving terms, admissions control with delayed retrials, and others. There are two basic and interconnected themes for these models. The first, dealt with in this part, concerns the definition of admissible control. The classical definition of an admissible control as a nonanticipative relaxed control is inadequate for these models and needs to be extended. This is needed for the convergence proofs of numerical approximations for optimal controls as well as to have a well-defined model. It is shown that the new classes of admissible controls do not enlarge the range of the value functions, is closed (together with the associated paths) under weak convergence, and is approximatable by ordinary controls. The second theme, dealt with in Part II, concerns transportation equation representations, and their role in the development of numerical algorithms with much reduced memory and computational requirements.

  17. A non-linear model of information seeking behaviour

    Directory of Open Access Journals (Sweden)

    Allen E. Foster

    2005-01-01

    Full Text Available The results of a qualitative, naturalistic, study of information seeking behaviour are reported in this paper. The study applied the methods recommended by Lincoln and Guba for maximising credibility, transferability, dependability, and confirmability in data collection and analysis. Sampling combined purposive and snowball methods, and led to a final sample of 45 inter-disciplinary researchers from the University of Sheffield. In-depth semi-structured interviews were used to elicit detailed examples of information seeking. Coding of interview transcripts took place in multiple iterations over time and used Atlas-ti software to support the process. The results of the study are represented in a non-linear Model of Information Seeking Behaviour. The model describes three core processes (Opening, Orientation, and Consolidation and three levels of contextual interaction (Internal Context, External Context, and Cognitive Approach, each composed of several individual activities and attributes. The interactivity and shifts described by the model show information seeking to be non-linear, dynamic, holistic, and flowing. The paper concludes by describing the whole model of behaviours as analogous to an artist's palette, in which activities remain available throughout information seeking. A summary of key implications of the model and directions for further research are included.

  18. Nonlinear spectral mixing theory to model multispectral signatures

    Energy Technology Data Exchange (ETDEWEB)

    Borel, C.C. [Los Alamos National Lab., NM (United States). Astrophysics and Radiation Measurements Group

    1996-02-01

    Nonlinear spectral mixing occurs due to multiple reflections and transmissions between discrete surfaces, e.g. leaves or facets of a rough surface. The radiosity method is an energy conserving computational method used in thermal engineering and it models nonlinear spectral mixing realistically and accurately. In contrast to the radiative transfer method the radiosity method takes into account the discreteness of the scattering surfaces (e.g. exact location, orientation and shape) such as leaves and includes mutual shading between them. An analytic radiosity-based scattering model for vegetation was developed and used to compute vegetation indices for various configurations. The leaf reflectance and transmittance was modeled using the PROSPECT model for various amounts of water, chlorophyll and variable leaf structure. The soil background was modeled using SOILSPEC with a linear mixture of reflectances of sand, clay and peat. A neural network and a geometry based retrieval scheme were used to retrieve leaf area index and chlorophyll concentration for dense canopies. Only simulated canopy reflectances in the 6 visible through short wave IR Landsat TM channels were used. The authors used an empirical function to compute the signal-to-noise ratio of a retrieved quantity.

  19. Nonlinear ECRH and ECCD modeling in toroidal devices

    International Nuclear Information System (INIS)

    Kamendje, R.; Kernbichler, W.; Heyn, M.F.; Kasilov, S.V.; Poli, E.

    2003-01-01

    A Monte Carlo method of evaluation of the electron distribution function which takes into account realistic orbits of electrons during their nonlinear cyclotron interaction with the wave beam has been proposed. The focus there was on a proper description of particle interaction with a wave beam while the geometry of the main magnetic field outside the beam was the simplest possible (slab model). In the actual work, a more realistic tokamak geometry has been implemented in the model. In addition, an expression for the parallel current density through Green's function has been used. This allows to reduce statistical errors which result from the fact that the current generated by particles with positive v parallel >0 is almost compensated by the current resulting from particles with v parallel <0 if the complete distribution function is taken into account in the expression for the current. The code ECNL which is a Monte Carlo kinetic equation solver based on this model, has been coupled with the beam tracing code TORBEAM. The results of nonlinear modeling of ECCD in a tokamak with ASDEX Upgrade parameters with help of this combination of codes are compared below to the results of linear modeling performed with TORBEAM alone. In addition, implications for stellarators are discussed. (orig.)

  20. Visualizing Statistical Mix Effects and Simpson's Paradox.

    Science.gov (United States)

    Armstrong, Zan; Wattenberg, Martin

    2014-12-01

    We discuss how "mix effects" can surprise users of visualizations and potentially lead them to incorrect conclusions. This statistical issue (also known as "omitted variable bias" or, in extreme cases, as "Simpson's paradox") is widespread and can affect any visualization in which the quantity of interest is an aggregated value such as a weighted sum or average. Our first contribution is to document how mix effects can be a serious issue for visualizations, and we analyze how mix effects can cause problems in a variety of popular visualization techniques, from bar charts to treemaps. Our second contribution is a new technique, the "comet chart," that is meant to ameliorate some of these issues.

  1. Rao-Blackwellization for Adaptive Gaussian Sum Nonlinear Model Propagation

    Science.gov (United States)

    Semper, Sean R.; Crassidis, John L.; George, Jemin; Mukherjee, Siddharth; Singla, Puneet

    2015-01-01

    When dealing with imperfect data and general models of dynamic systems, the best estimate is always sought in the presence of uncertainty or unknown parameters. In many cases, as the first attempt, the Extended Kalman filter (EKF) provides sufficient solutions to handling issues arising from nonlinear and non-Gaussian estimation problems. But these issues may lead unacceptable performance and even divergence. In order to accurately capture the nonlinearities of most real-world dynamic systems, advanced filtering methods have been created to reduce filter divergence while enhancing performance. Approaches, such as Gaussian sum filtering, grid based Bayesian methods and particle filters are well-known examples of advanced methods used to represent and recursively reproduce an approximation to the state probability density function (pdf). Some of these filtering methods were conceptually developed years before their widespread uses were realized. Advanced nonlinear filtering methods currently benefit from the computing advancements in computational speeds, memory, and parallel processing. Grid based methods, multiple-model approaches and Gaussian sum filtering are numerical solutions that take advantage of different state coordinates or multiple-model methods that reduced the amount of approximations used. Choosing an efficient grid is very difficult for multi-dimensional state spaces, and oftentimes expensive computations must be done at each point. For the original Gaussian sum filter, a weighted sum of Gaussian density functions approximates the pdf but suffers at the update step for the individual component weight selections. In order to improve upon the original Gaussian sum filter, Ref. [2] introduces a weight update approach at the filter propagation stage instead of the measurement update stage. This weight update is performed by minimizing the integral square difference between the true forecast pdf and its Gaussian sum approximation. By adaptively updating

  2. Neutron stars in non-linear coupling models

    International Nuclear Information System (INIS)

    Taurines, Andre R.; Vasconcellos, Cesar A.Z.; Malheiro, Manuel; Chiapparini, Marcelo

    2001-01-01

    We present a class of relativistic models for nuclear matter and neutron stars which exhibits a parameterization, through mathematical constants, of the non-linear meson-baryon couplings. For appropriate choices of the parameters, it recovers current QHD models found in the literature: Walecka, ZM and ZM3 models. We have found that the ZM3 model predicts a very small maximum neutron star mass, ∼ 0.72M s un. A strong similarity between the results of ZM-like models and those with exponential couplings is noted. Finally, we discuss the very intense scalar condensates found in the interior of neutron stars which may lead to negative effective masses. (author)

  3. Neutron stars in non-linear coupling models

    Energy Technology Data Exchange (ETDEWEB)

    Taurines, Andre R.; Vasconcellos, Cesar A.Z. [Rio Grande do Sul Univ., Porto Alegre, RS (Brazil); Malheiro, Manuel [Universidade Federal Fluminense, Niteroi, RJ (Brazil); Chiapparini, Marcelo [Universidade do Estado, Rio de Janeiro, RJ (Brazil)

    2001-07-01

    We present a class of relativistic models for nuclear matter and neutron stars which exhibits a parameterization, through mathematical constants, of the non-linear meson-baryon couplings. For appropriate choices of the parameters, it recovers current QHD models found in the literature: Walecka, ZM and ZM3 models. We have found that the ZM3 model predicts a very small maximum neutron star mass, {approx} 0.72M{sub s}un. A strong similarity between the results of ZM-like models and those with exponential couplings is noted. Finally, we discuss the very intense scalar condensates found in the interior of neutron stars which may lead to negative effective masses. (author)

  4. A nonlinear model of gold production in Malaysia

    Science.gov (United States)

    Ramli, Norashikin; Muda, Nora; Umor, Mohd Rozi

    2014-06-01

    Malaysia is a country which is rich in natural resources and one of it is a gold. Gold has already become an important national commodity. This study is conducted to determine a model that can be well fitted with the gold production in Malaysia from the year 1995-2010. Five nonlinear models are presented in this study which are Logistic model, Gompertz, Richard, Weibull and Chapman-Richard model. These model are used to fit the cumulative gold production in Malaysia. The best model is then selected based on the model performance. The performance of the fitted model is measured by sum squares error, root mean squares error, coefficient of determination, mean relative error, mean absolute error and mean absolute percentage error. This study has found that a Weibull model is shown to have significantly outperform compare to the other models. To confirm that Weibull is the best model, the latest data are fitted to the model. Once again, Weibull model gives the lowest readings at all types of measurement error. We can concluded that the future gold production in Malaysia can be predicted according to the Weibull model and this could be important findings for Malaysia to plan their economic activities.

  5. Nonlinear wave equation in frequency domain: accurate modeling of ultrafast interaction in anisotropic nonlinear media

    DEFF Research Database (Denmark)

    Guo, Hairun; Zeng, Xianglong; Zhou, Binbin

    2013-01-01

    We interpret the purely spectral forward Maxwell equation with up to third-order induced polarizations for pulse propagation and interactions in quadratic nonlinear crystals. The interpreted equation, also named the nonlinear wave equation in the frequency domain, includes quadratic and cubic...... nonlinearities, delayed Raman effects, and anisotropic nonlinearities. The full potential of this wave equation is demonstrated by investigating simulations of solitons generated in the process of ultrafast cascaded second-harmonic generation. We show that a balance in the soliton delay can be achieved due...

  6. Anomalous Transport of Cosmic Rays in a Nonlinear Diffusion Model

    Energy Technology Data Exchange (ETDEWEB)

    Litvinenko, Yuri E. [Department of Mathematics, University of Waikato, P. B. 3105, Hamilton 3240 (New Zealand); Fichtner, Horst; Walter, Dominik [Institut für Theoretische Physik IV, Ruhr-Universität Bochum, Universitätsstrasse 150, D-44780 Bochum (Germany)

    2017-05-20

    We investigate analytically and numerically the transport of cosmic rays following their escape from a shock or another localized acceleration site. Observed cosmic-ray distributions in the vicinity of heliospheric and astrophysical shocks imply that anomalous, superdiffusive transport plays a role in the evolution of the energetic particles. Several authors have quantitatively described the anomalous diffusion scalings, implied by the data, by solutions of a formal transport equation with fractional derivatives. Yet the physical basis of the fractional diffusion model remains uncertain. We explore an alternative model of the cosmic-ray transport: a nonlinear diffusion equation that follows from a self-consistent treatment of the resonantly interacting cosmic-ray particles and their self-generated turbulence. The nonlinear model naturally leads to superdiffusive scalings. In the presence of convection, the model yields a power-law dependence of the particle density on the distance upstream of the shock. Although the results do not refute the use of a fractional advection–diffusion equation, they indicate a viable alternative to explain the anomalous diffusion scalings of cosmic-ray particles.

  7. Models of the delayed nonlinear Raman response in diatomic gases

    International Nuclear Information System (INIS)

    Palastro, J. P.; Antonsen, T. M. Jr.; Pearson, A.

    2011-01-01

    We examine the delayed response of a diatomic gas to a polarizing laser field with the goal of obtaining computationally efficient methods for use with laser pulse propagation simulations. We demonstrate that for broadband pulses, heavy molecules such as O 2 and N 2 , and typical atmospheric temperatures, the initial delayed response requires only classical physics. The linear kinetic Green's function is derived from the Boltzmann equation and shown to be in excellent agreement with full density-matrix calculations. A straightforward perturbation approach for the fully nonlinear, kinetic impulse response is also presented. With the kinetic theory a reduced fluid model of the diatomic gas' orientation is derived. Transport coefficients are introduced to model the kinetic phase mixing of the delayed response. In addition to computational rapidity, the fluid model provides intuition through the use of familiar macroscopic quantities. Both the kinetic and the fluid descriptions predict a nonlinear steady-state alignment after passage of the laser pulse, which in the fluid model is interpreted as an anisotropic temperature of the diatomic fluid with respect to motion about the polarization axis.

  8. Nonlinear spherical perturbations in quintessence models of dark energy

    Science.gov (United States)

    Pratap Rajvanshi, Manvendra; Bagla, J. S.

    2018-06-01

    Observations have confirmed the accelerated expansion of the universe. The accelerated expansion can be modelled by invoking a cosmological constant or a dynamical model of dark energy. A key difference between these models is that the equation of state parameter w for dark energy differs from ‑1 in dynamical dark energy (DDE) models. Further, the equation of state parameter is not constant for a general DDE model. Such differences can be probed using the variation of scale factor with time by measuring distances. Another significant difference between the cosmological constant and DDE models is that the latter must cluster. Linear perturbation analysis indicates that perturbations in quintessence models of dark energy do not grow to have a significant amplitude at small length scales. In this paper we study the response of quintessence dark energy to non-linear perturbations in dark matter. We use a fully relativistic model for spherically symmetric perturbations. In this study we focus on thawing models. We find that in response to non-linear perturbations in dark matter, dark energy perturbations grow at a faster rate than expected in linear perturbation theory. We find that dark energy perturbation remains localised and does not diffuse out to larger scales. The dominant drivers of the evolution of dark energy perturbations are the local Hubble flow and a supression of gradients of the scalar field. We also find that the equation of state parameter w changes in response to perturbations in dark matter such that it also becomes a function of position. The variation of w in space is correlated with density contrast for matter. Variation of w and perturbations in dark energy are more pronounced in response to large scale perturbations in matter while the dependence on the amplitude of matter perturbations is much weaker.

  9. Fault Diagnosis of Nonlinear Systems Using Structured Augmented State Models

    Institute of Scientific and Technical Information of China (English)

    Jochen Aβfalg; Frank Allg(o)wer

    2007-01-01

    This paper presents an internal model approach for modeling and diagnostic functionality design for nonlinear systems operating subject to single- and multiple-faults. We therefore provide the framework of structured augmented state models. Fault characteristics are considered to be generated by dynamical exosystems that are switched via equality constraints to overcome the augmented state observability limiting the number of diagnosable faults. Based on the proposed model, the fault diagnosis problem is specified as an optimal hybrid augmented state estimation problem. Sub-optimal solutions are motivated and exemplified for the fault diagnosis of the well-known three-tank benchmark. As the considered class of fault diagnosis problems is large, the suggested approach is not only of theoretical interest but also of high practical relevance.

  10. Nonlinear flight dynamics and stability of hovering model insects

    Science.gov (United States)

    Liang, Bin; Sun, Mao

    2013-01-01

    Current analyses on insect dynamic flight stability are based on linear theory and limited to small disturbance motions. However, insects' aerial environment is filled with swirling eddies and wind gusts, and large disturbances are common. Here, we numerically solve the equations of motion coupled with the Navier–Stokes equations to simulate the large disturbance motions and analyse the nonlinear flight dynamics of hovering model insects. We consider two representative model insects, a model hawkmoth (large size, low wingbeat frequency) and a model dronefly (small size, high wingbeat frequency). For small and large initial disturbances, the disturbance motion grows with time, and the insects tumble and never return to the equilibrium state; the hovering flight is inherently (passively) unstable. The instability is caused by a pitch moment produced by forward/backward motion and/or a roll moment produced by side motion of the insect. PMID:23697714

  11. Dynamics in a nonlinear Keynesian good market model

    International Nuclear Information System (INIS)

    Naimzada, Ahmad; Pireddu, Marina

    2014-01-01

    In this paper, we show how a rich variety of dynamical behaviors can emerge in the standard Keynesian income-expenditure model when a nonlinearity is introduced, both in the cases with and without endogenous government spending. A specific sigmoidal functional form is used for the adjustment mechanism of income with respect to the excess demand, in order to bound the income variation. With the aid of analytical and numerical tools, we investigate the stability conditions, bifurcations, as well as periodic and chaotic dynamics. Globally, we study multistability phenomena, i.e., the coexistence of different kinds of attractors

  12. A Disentangled Recognition and Nonlinear Dynamics Model for Unsupervised Learning

    DEFF Research Database (Denmark)

    Fraccaro, Marco; Kamronn, Simon Due; Paquet, Ulrich

    2017-01-01

    This paper takes a step towards temporal reasoning in a dynamically changing video, not in the pixel space that constitutes its frames, but in a latent space that describes the non-linear dynamics of the objects in its world. We introduce the Kalman variational auto-encoder, a framework...... for unsupervised learning of sequential data that disentangles two latent representations: an object’s representation, coming from a recognition model, and a latent state describing its dynamics. As a result, the evolution of the world can be imagined and missing data imputed, both without the need to generate...

  13. Visualization of nonlinear kernel models in neuroimaging by sensitivity maps

    DEFF Research Database (Denmark)

    Rasmussen, Peter Mondrup; Hansen, Lars Kai; Madsen, Kristoffer Hougaard

    There is significant current interest in decoding mental states from neuroimages. In this context kernel methods, e.g., support vector machines (SVM) are frequently adopted to learn statistical relations between patterns of brain activation and experimental conditions. In this paper we focus...... on visualization of such nonlinear kernel models. Specifically, we investigate the sensitivity map as a technique for generation of global summary maps of kernel classification methods. We illustrate the performance of the sensitivity map on functional magnetic resonance (fMRI) data based on visual stimuli. We...

  14. Parameter Identification for Nonlinear Circuit Models of Power BAW Resonator

    Directory of Open Access Journals (Sweden)

    CONSTANTINESCU, F.

    2011-02-01

    Full Text Available The large signal operation of the bulk acoustic wave (BAW resonators is characterized by the amplitude-frequency effect and the intermodulation effect. The measurement of these effects, together with that of the small signal frequency characteristic, are used in this paper for the parameter identification of the nonlinear circuit models developed previously by authors. As the resonator has been connected to the measurement bench by wire bonding, the parasitic elements of this connection have been taken into account, being estimated solving some electrical and magnetic field problems.

  15. Nonlinear model of epidemic spreading in a complex social network.

    Science.gov (United States)

    Kosiński, Robert A; Grabowski, A

    2007-10-01

    The epidemic spreading in a human society is a complex process, which can be described on the basis of a nonlinear mathematical model. In such an approach the complex and hierarchical structure of social network (which has implications for the spreading of pathogens and can be treated as a complex network), can be taken into account. In our model each individual has one of the four permitted states: susceptible, infected, infective, unsusceptible or dead. This refers to the SEIR model used in epidemiology. The state of an individual changes in time, depending on the previous state and the interactions with other individuals. The description of the interpersonal contacts is based on the experimental observations of the social relations in the community. It includes spatial localization of the individuals and hierarchical structure of interpersonal interactions. Numerical simulations were performed for different types of epidemics, giving the progress of a spreading process and typical relationships (e.g. range of epidemic in time, the epidemic curve). The spreading process has a complex and spatially chaotic character. The time dependence of the number of infective individuals shows the nonlinear character of the spreading process. We investigate the influence of the preventive vaccinations on the spreading process. In particular, for a critical value of preventively vaccinated individuals the percolation threshold is observed and the epidemic is suppressed.

  16. On concurvity in nonlinear and nonparametric regression models

    Directory of Open Access Journals (Sweden)

    Sonia Amodio

    2014-12-01

    Full Text Available When data are affected by multicollinearity in the linear regression framework, then concurvity will be present in fitting a generalized additive model (GAM. The term concurvity describes nonlinear dependencies among the predictor variables. As collinearity results in inflated variance of the estimated regression coefficients in the linear regression model, the result of the presence of concurvity leads to instability of the estimated coefficients in GAMs. Even if the backfitting algorithm will always converge to a solution, in case of concurvity the final solution of the backfitting procedure in fitting a GAM is influenced by the starting functions. While exact concurvity is highly unlikely, approximate concurvity, the analogue of multicollinearity, is of practical concern as it can lead to upwardly biased estimates of the parameters and to underestimation of their standard errors, increasing the risk of committing type I error. We compare the existing approaches to detect concurvity, pointing out their advantages and drawbacks, using simulated and real data sets. As a result, this paper will provide a general criterion to detect concurvity in nonlinear and non parametric regression models.

  17. Empirical intrinsic geometry for nonlinear modeling and time series filtering.

    Science.gov (United States)

    Talmon, Ronen; Coifman, Ronald R

    2013-07-30

    In this paper, we present a method for time series analysis based on empirical intrinsic geometry (EIG). EIG enables one to reveal the low-dimensional parametric manifold as well as to infer the underlying dynamics of high-dimensional time series. By incorporating concepts of information geometry, this method extends existing geometric analysis tools to support stochastic settings and parametrizes the geometry of empirical distributions. However, the statistical models are not required as priors; hence, EIG may be applied to a wide range of real signals without existing definitive models. We show that the inferred model is noise-resilient and invariant under different observation and instrumental modalities. In addition, we show that it can be extended efficiently to newly acquired measurements in a sequential manner. These two advantages enable us to revisit the Bayesian approach and incorporate empirical dynamics and intrinsic geometry into a nonlinear filtering framework. We show applications to nonlinear and non-Gaussian tracking problems as well as to acoustic signal localization.

  18. Numerical studies on the electromagnetic properties of the nonlinear Lorentz Computational model for the dielectric media

    International Nuclear Information System (INIS)

    Abe, H.; Okuda, H.

    1994-06-01

    We study linear and nonlinear properties of a new computer simulation model developed to study the propagation of electromagnetic waves in a dielectric medium in the linear and nonlinear regimes. The model is constructed by combining a microscopic model used in the semi-classical approximation for the dielectric media and the particle model developed for the plasma simulations. It is shown that the model may be useful for studying linear and nonlinear wave propagation in the dielectric media

  19. Parametric model of servo-hydraulic actuator coupled with a nonlinear system: Experimental validation

    Science.gov (United States)

    Maghareh, Amin; Silva, Christian E.; Dyke, Shirley J.

    2018-05-01

    Hydraulic actuators play a key role in experimental structural dynamics. In a previous study, a physics-based model for a servo-hydraulic actuator coupled with a nonlinear physical system was developed. Later, this dynamical model was transformed into controllable canonical form for position tracking control purposes. For this study, a nonlinear device is designed and fabricated to exhibit various nonlinear force-displacement profiles depending on the initial condition and the type of materials used as replaceable coupons. Using this nonlinear system, the controllable canonical dynamical model is experimentally validated for a servo-hydraulic actuator coupled with a nonlinear physical system.

  20. Modelling non-linear effects of dark energy

    Science.gov (United States)

    Bose, Benjamin; Baldi, Marco; Pourtsidou, Alkistis

    2018-04-01

    We investigate the capabilities of perturbation theory in capturing non-linear effects of dark energy. We test constant and evolving w models, as well as models involving momentum exchange between dark energy and dark matter. Specifically, we compare perturbative predictions at 1-loop level against N-body results for four non-standard equations of state as well as varying degrees of momentum exchange between dark energy and dark matter. The interaction is modelled phenomenologically using a time dependent drag term in the Euler equation. We make comparisons at the level of the matter power spectrum and the redshift space monopole and quadrupole. The multipoles are modelled using the Taruya, Nishimichi and Saito (TNS) redshift space spectrum. We find perturbation theory does very well in capturing non-linear effects coming from dark sector interaction. We isolate and quantify the 1-loop contribution coming from the interaction and from the non-standard equation of state. We find the interaction parameter ξ amplifies scale dependent signatures in the range of scales considered. Non-standard equations of state also give scale dependent signatures within this same regime. In redshift space the match with N-body is improved at smaller scales by the addition of the TNS free parameter σv. To quantify the importance of modelling the interaction, we create mock data sets for varying values of ξ using perturbation theory. This data is given errors typical of Stage IV surveys. We then perform a likelihood analysis using the first two multipoles on these sets and a ξ=0 modelling, ignoring the interaction. We find the fiducial growth parameter f is generally recovered even for very large values of ξ both at z=0.5 and z=1. The ξ=0 modelling is most biased in its estimation of f for the phantom w=‑1.1 case.

  1. Nonlinear realizations and effective Lagrangian densities for nonlinear σ-models

    International Nuclear Information System (INIS)

    Hamilton-Charlton, Jason Dominic

    2003-01-01

    Nonlinear realizations of the groups SU(N), SO(m) and SO(t,s) are analysed, described by the coset spaces SU(N) / SU(N-1) x U(1), SO(m) / SO(m-1), SO(1,m-1) / SO(1,m-2) and SO(m) / SO(m-2 x SO(2). The analysis consists of determining the transformation properties of the Goldstone Bosons, constructing the most general possible Lagrangian for the realizations, and as a result identifying the coset space metric. We view the λ matrices of SU(N) as being the basis of an (N 2 - 1) dimensional real vector space, and from this we learn how to construct the basis of a Cartan Subspace associated with a vector. This results in a mathematical structure which allows us to find expressions for coset representative elements used in the analysis. This structure is not only relevant to SU(N) breaking models, but may also be used to find results in SO(m) and SO(1,m - 1) breaking models. (author)

  2. Nonlinear modeling and identification of a DC motor for bidirectional operation with real time experiments

    International Nuclear Information System (INIS)

    Kara, Tolgay; Eker, Ilyas

    2004-01-01

    Modeling and identification of mechanical systems constitute an essential stage in practical control design and applications. Controllers commanding systems that operate at varying conditions or require high precision operation raise the need for a nonlinear approach in modeling and identification. Most mechanical systems used in industry are composed of masses moving under the action of position and velocity dependent forces. These forces exhibit nonlinear behavior in certain regions of operation. For a multi-mass rotational system, the nonlinearities, like Coulomb friction and dead zone, significantly influence the system operation when the rotation changes direction. The paper presents nonlinear modeling and identification of a DC motor rotating in two directions together with real time experiments. Linear and nonlinear models for the system are obtained for identification purposes, and the major nonlinearities in the system, such as Coulomb friction and dead zone, are investigated and integrated in the nonlinear model. The Hammerstein nonlinear system approach is used for identification of the nonlinear system model. Online identification of the linear and nonlinear system models is performed using the recursive least squares method. Results of the real time experiments are graphically and numerically presented, and the advantages of the nonlinear identification approach are revealed

  3. A NONLINEAR MATHEMATICAL MODEL FOR ASTHMA: EFFECT OF ENVIRONMENTAL POLLUTION

    Directory of Open Access Journals (Sweden)

    NARESHA RAM

    2009-04-01

    Full Text Available In this paper, we explore a nonlinear mathematical model to study the spread of asthma due to inhaled pollutants from industry as well as tobacco smoke from smokers in a variable size population. The model is analyzed using stability theory of differential equations and computer simulation. It is shown that with an increase in the level of air pollutants concentration, the asthmatic (diseased population increases. It is also shown that along with pollutants present in the environment, smoking (active or passive also helps in the spread of asthma. Moreover, with the increase in the rate of interaction between susceptibles and smokers, the persistence of the spread of asthma is higher. A numerical study of the model is also performed to see the role of certain key parameters on the spread of asthma and to support the analytical results.

  4. Fluid mechanics and heat transfer advances in nonlinear dynamics modeling

    CERN Document Server

    Asli, Kaveh Hariri

    2015-01-01

    This valuable new book focuses on new methods and techniques in fluid mechanics and heat transfer in mechanical engineering. The book includes the research of the authors on the development of optimal mathematical models and also uses modern computer technology and mathematical methods for the analysis of nonlinear dynamic processes. It covers technologies applicable to both fluid mechanics and heat transfer problems, which include a combination of physical, mechanical, and thermal techniques. The authors develop a new method for the calculation of mathematical models by computer technology, using parametric modeling techniques and multiple analyses for mechanical system. The information in this book is intended to help reduce the risk of system damage or failure. Included are sidebar discussions, which contain information and facts about each subject area that help to emphasize important points to remember.

  5. Lectures on nonlinear sigma-models in projective superspace

    International Nuclear Information System (INIS)

    Kuzenko, Sergei M

    2010-01-01

    N= 2 supersymmetry in four spacetime dimensions is intimately related to hyperkaehler and quaternionic Kaehler geometries. On one hand, the target spaces for rigid supersymmetric sigma-models are necessarily hyperkaehler manifolds. On the other hand, when coupled to N= 2 supergravity, the sigma-model target spaces must be quaternionic Kaehler. It is known that such manifolds of restricted holonomy are difficult to generate explicitly. Projective superspace is a field-theoretic approach to construct general N= 2 supersymmetric nonlinear sigma-models, and hence to generate new hyperkaehler and quaternionic Kaehler metrics. Intended for a mixed audience consisting of both physicists and mathematicians, these lectures provide a pedagogical introduction to the projective-superspace approach. (topical review)

  6. Lectures on nonlinear sigma-models in projective superspace

    Energy Technology Data Exchange (ETDEWEB)

    Kuzenko, Sergei M, E-mail: kuzenko@cyllene.uwa.edu.a [School of Physics M013, University of Western Australia, 35 Stirling Highway, Crawley WA 6009 (Australia)

    2010-11-05

    N= 2 supersymmetry in four spacetime dimensions is intimately related to hyperkaehler and quaternionic Kaehler geometries. On one hand, the target spaces for rigid supersymmetric sigma-models are necessarily hyperkaehler manifolds. On the other hand, when coupled to N= 2 supergravity, the sigma-model target spaces must be quaternionic Kaehler. It is known that such manifolds of restricted holonomy are difficult to generate explicitly. Projective superspace is a field-theoretic approach to construct general N= 2 supersymmetric nonlinear sigma-models, and hence to generate new hyperkaehler and quaternionic Kaehler metrics. Intended for a mixed audience consisting of both physicists and mathematicians, these lectures provide a pedagogical introduction to the projective-superspace approach. (topical review)

  7. Estimation of Nonlinear Dynamic Panel Data Models with Individual Effects

    Directory of Open Access Journals (Sweden)

    Yi Hu

    2014-01-01

    Full Text Available This paper suggests a generalized method of moments (GMM based estimation for dynamic panel data models with individual specific fixed effects and threshold effects simultaneously. We extend Hansen’s (Hansen, 1999 original setup to models including endogenous regressors, specifically, lagged dependent variables. To address the problem of endogeneity of these nonlinear dynamic panel data models, we prove that the orthogonality conditions proposed by Arellano and Bond (1991 are valid. The threshold and slope parameters are estimated by GMM, and asymptotic distribution of the slope parameters is derived. Finite sample performance of the estimation is investigated through Monte Carlo simulations. It shows that the threshold and slope parameter can be estimated accurately and also the finite sample distribution of slope parameters is well approximated by the asymptotic distribution.

  8. Magnetically nonlinear dynamic model of synchronous motor with permanent magnets

    International Nuclear Information System (INIS)

    Hadziselimovic, Miralem; Stumberger, Gorazd; Stumberger, Bojan; Zagradisnik, Ivan

    2007-01-01

    This paper deals with a magnetically nonlinear two-axis dynamic model of a permanent magnet synchronous motor (PMSM). The geometrical and material properties of iron core and permanent magnets, the effects of winding distribution, saturation, cross-saturation and slotting effects are, for the first time, simultaneously accounted for in a single two-axis dynamic model of a three-phase PMSM. They are accounted for by current- and position-dependent characteristics of flux linkages. These characteristics can be determined either experimentally or by the finite element (FE) computations. The results obtained by the proposed dynamic model show a very good agreement with the measured ones and those obtained by the FE computation

  9. Primary Radiation Damage in Materials. Review of Current Understanding and Proposed New Standard Displacement Damage Model to Incorporate in Cascade Defect Production Efficiency and Mixing Effects

    International Nuclear Information System (INIS)

    Nordlund, Kai; Sand, Andrea E.; Granberg, Fredric; Zinkle, Steven J.; Stoller, Roger; Averback, Robert S.; Suzudo, Tomoaki; Malerba, Lorenzo; Banhart, Florian; Weber, William J.; Willaime, Francois; Dudarev, Sergei; Simeone, David

    2015-01-01

    Under the auspices of the NEA Nuclear Science Committee (NSC), the Working Party on Multi-scale Modelling of Fuels and Structural Materials for Nuclear Systems (WPMM) was established in 2008 to assess the scientific and engineering aspects of fuels and structural materials, aiming at evaluating multi-scale models and simulations as validated predictive tools for the design of nuclear systems, fuel fabrication and performance. The WPMM's objective is to promote the exchange of information on models and simulations of nuclear materials, theoretical and computational methods, experimental validation, and related topics. It also provides member countries with up-to-date information, shared data, models and expertise. The WPMM Expert Group on Primary Radiation Damage (PRD) was established in 2009 to determine the limitations of the NRT-dpa standard, in the light of both atomistic simulations and known experimental discrepancies, to revisit the NRT-dpa standard and to examine the possibility of proposing a new improved standard of primary damage characteristics. This report reviews the current understanding of primary radiation damage from neutrons, ions and electrons (excluding photons, atomic clusters and more exotic particles), with emphasis on the range of validity of the 'displacement per atom' (dpa) concept in all major classes of materials with the exception of organics. The report also introduces an 'athermal recombination-corrected dpa' (arc-dpa) relation that uses a relatively simple functional to address the well-known issue that 'displacement per atom' (dpa) overestimates damage production in metals under energetic displacement cascade conditions, as well as a 'replacements-per-atom' (rpa) equation, also using a relatively simple functional, that accounts for the fact that dpa is understood to severely underestimate actual atom relocation (ion beam mixing) in metals. (authors)

  10. The coefficient of determination R2 and intra-class correlation coefficient from generalized linear mixed-effects models revisited and expanded.

    Science.gov (United States)

    Nakagawa, Shinichi; Johnson, Paul C D; Schielzeth, Holger

    2017-09-01

    The coefficient of determination R 2 quantifies the proportion of variance explained by a statistical model and is an important summary statistic of biological interest. However, estimating R 2 for generalized linear mixed models (GLMMs) remains challenging. We have previously introduced a version of R 2 that we called [Formula: see text] for Poisson and binomial GLMMs, but not for other distributional families. Similarly, we earlier discussed how to estimate intra-class correlation coefficients (ICCs) using Poisson and binomial GLMMs. In this paper, we generalize our methods to all other non-Gaussian distributions, in particular to negative binomial and gamma distributions that are commonly used for modelling biological data. While expanding our approach, we highlight two useful concepts for biologists, Jensen's inequality and the delta method, both of which help us in understanding the properties of GLMMs. Jensen's inequality has important implications for biologically meaningful interpretation of GLMMs, whereas the delta method allows a general derivation of variance associated with non-Gaussian distributions. We also discuss some special considerations for binomial GLMMs with binary or proportion data. We illustrate the implementation of our extension by worked examples from the field of ecology and evolution in the R environment. However, our method can be used across disciplines and regardless of statistical environments. © 2017 The Author(s).

  11. Hyperbolicity of the Nonlinear Models of Maxwell's Equations

    Science.gov (United States)

    Serre, Denis

    . We consider the class of nonlinear models of electromagnetism that has been described by Coleman & Dill [7]. A model is completely determined by its energy density W(B,D). Viewing the electromagnetic field (B,D) as a 3×2 matrix, we show that polyconvexity of W implies the local well-posedness of the Cauchy problem within smooth functions of class Hs with s>1+d/2. The method follows that designed by Dafermos in his book [9] in the context of nonlinear elasticity. We use the fact that B×D is a (vectorial, non-convex) entropy, and we enlarge the system from 6 to 9 equations. The resulting system admits an entropy (actually the energy) that is convex. Since the energy conservation law does not derive from the system of conservation laws itself (Faraday's and Ampère's laws), but also needs the compatibility relations divB=divD=0 (the latter may be relaxed in order to take into account electric charges), the energy density is not an entropy in the classical sense. Thus the system cannot be symmetrized, strictly speaking. However, we show that the structure is close enough to symmetrizability, so that the standard estimates still hold true.

  12. Identification of a Class of Non-linear State Space Models using RPE Techniques

    DEFF Research Database (Denmark)

    Zhou, Wei-Wu; Blanke, Mogens

    1989-01-01

    The RPE (recursive prediction error) method in state-space form is developed in the nonlinear systems and extended to include the exact form of a nonlinearity, thus enabling structure preservation for certain classes of nonlinear systems. Both the discrete and the continuous-discrete versions...... of the algorithm in an innovations model are investigated, and a nonlinear simulation example shows a quite convincing performance of the filter as combined parameter and state estimator...

  13. Quasilinear Extreme Learning Machine Model Based Internal Model Control for Nonlinear Process

    Directory of Open Access Journals (Sweden)

    Dazi Li

    2015-01-01

    Full Text Available A new strategy for internal model control (IMC is proposed using a regression algorithm of quasilinear model with extreme learning machine (QL-ELM. Aimed at the chemical process with nonlinearity, the learning process of the internal model and inverse model is derived. The proposed QL-ELM is constructed as a linear ARX model with a complicated nonlinear coefficient. It shows some good approximation ability and fast convergence. The complicated coefficients are separated into two parts. The linear part is determined by recursive least square (RLS, while the nonlinear part is identified through extreme learning machine. The parameters of linear part and the output weights of ELM are estimated iteratively. The proposed internal model control is applied to CSTR process. The effectiveness and accuracy of the proposed method are extensively verified through numerical results.

  14. Non-perturbative aspects of nonlinear sigma models

    Energy Technology Data Exchange (ETDEWEB)

    Flore, Raphael

    2012-12-07

    The aim of this thesis was the study and further development of non-perturbative methods of quantum field theory by means of their application to nonlinear sigma models. While a large part of the physical phenomena of quantum field theory can be successfully predicted by the perturbation theory, some aspects in the region of large coupling strengths are not definitively understood and require suited non-perturbative methods for its analysis. This thesis is concentrated on two approaches, the numerical treatment of field theories on discrete space-time lattices and the functional renormalization group (FRG) as description of the renormalization flux of effective actions. Considerations of the nonlinear O(N) models have shown that for the correct analysis of the critical properties in the framework of the FRG an approach must be chosen, which contained fourth-derivation orders. For this a covariant formalism was developed, which is based on a background-field expansion and the development of a heat kernel. Apart from a destabilizing coupling the results suggest a nontrivial fixed point and by this a non-perturbative renormalizability of these models. The resulting flow diagrams were finally still compared with the results of a numerical analysis of the renormalization flow by means of the Monte-Carlo renormalization group, and hereby qualitative agreement was found. Furthermore an alternative formulation of the FRG in phase-space coordinates was studied and their consistency tested on simple examples. Beyond this an alternative expansion of the effective action in orders of the canonical momenta was applied to the nonlinear O(N) models with the result of a stable non-trivial fixed point, the critical properties of which however show not the expected N-dependence. By means of the FRG finally still the renormalization of topological operators was studied by means of the winding number of the O(3){approx_equal}CP{sup 1} model. By the generalization of the topological

  15. Non-perturbative aspects of nonlinear sigma models

    International Nuclear Information System (INIS)

    Flore, Raphael

    2012-01-01

    The aim of this thesis was the study and further development of non-perturbative methods of quantum field theory by means of their application to nonlinear sigma models. While a large part of the physical phenomena of quantum field theory can be successfully predicted by the perturbation theory, some aspects in the region of large coupling strengths are not definitively understood and require suited non-perturbative methods for its analysis. This thesis is concentrated on two approaches, the numerical treatment of field theories on discrete space-time lattices and the functional renormalization group (FRG) as description of the renormalization flux of effective actions. Considerations of the nonlinear O(N) models have shown that for the correct analysis of the critical properties in the framework of the FRG an approach must be chosen, which contained fourth-derivation orders. For this a covariant formalism was developed, which is based on a background-field expansion and the development of a heat kernel. Apart from a destabilizing coupling the results suggest a nontrivial fixed point and by this a non-perturbative renormalizability of these models. The resulting flow diagrams were finally still compared with the results of a numerical analysis of the renormalization flow by means of the Monte-Carlo renormalization group, and hereby qualitative agreement was found. Furthermore an alternative formulation of the FRG in phase-space coordinates was studied and their consistency tested on simple examples. Beyond this an alternative expansion of the effective action in orders of the canonical momenta was applied to the nonlinear O(N) models with the result of a stable non-trivial fixed point, the critical properties of which however show not the expected N-dependence. By means of the FRG finally still the renormalization of topological operators was studied by means of the winding number of the O(3)≅CP 1 model. By the generalization of the topological operator and the

  16. New exact travelling wave solutions of nonlinear physical models

    International Nuclear Information System (INIS)

    Bekir, Ahmet; Cevikel, Adem C.

    2009-01-01

    In this work, we established abundant travelling wave solutions for some nonlinear evolution equations. This method was used to construct travelling wave solutions of nonlinear evolution equations. The travelling wave solutions are expressed by the hyperbolic functions, the trigonometric functions and the rational functions. The ((G ' )/G )-expansion method presents a wider applicability for handling nonlinear wave equations.

  17. Effect of P T symmetry on nonlinear waves for three-wave interaction models in the quadratic nonlinear media

    Science.gov (United States)

    Shen, Yujia; Wen, Zichao; Yan, Zhenya; Hang, Chao

    2018-04-01

    We study the three-wave interaction that couples an electromagnetic pump wave to two frequency down-converted daughter waves in a quadratic optical crystal and P T -symmetric potentials. P T symmetric potentials are shown to modulate stably nonlinear modes in two kinds of three-wave interaction models. The first one is a spatially extended three-wave interaction system with odd gain-and-loss distribution in the channel. Modulated by the P T -symmetric single-well or multi-well Scarf-II potentials, the system is numerically shown to possess stable soliton solutions. Via adiabatical change of system parameters, numerical simulations for the excitation and evolution of nonlinear modes are also performed. The second one is a combination of P T -symmetric models which are coupled via three-wave interactions. Families of nonlinear modes are found with some particular choices of parameters. Stable and unstable nonlinear modes are shown in distinct families by means of numerical simulations. These results will be useful to further investigate nonlinear modes in three-wave interaction models.

  18. Nonlinear Fuzzy Model Predictive Control for a PWR Nuclear Power Plant

    Directory of Open Access Journals (Sweden)

    Xiangjie Liu

    2014-01-01

    Full Text Available Reliable power and temperature control in pressurized water reactor (PWR nuclear power plant is necessary to guarantee high efficiency and plant safety. Since the nuclear plants are quite nonlinear, the paper presents nonlinear fuzzy model predictive control (MPC, by incorporating the realistic constraints, to realize the plant optimization. T-S fuzzy modeling on nuclear power plant is utilized to approximate the nonlinear plant, based on which the nonlinear MPC controller is devised via parallel distributed compensation (PDC scheme in order to solve the nonlinear constraint optimization problem. Improved performance compared to the traditional PID controller for a TMI-type PWR is obtained in the simulation.

  19. Parameter identification in a nonlinear nuclear reactor model using quasilinearization

    International Nuclear Information System (INIS)

    Barreto, J.M.; Martins Neto, A.F.; Tanomaru, N.

    1980-09-01

    Parameter identification in a nonlinear, lumped parameter, nuclear reactor model is carried out using discrete output power measurements during the transient caused by an external reactivity change. In order to minimize the difference between the model and the reactor power responses, the parameter promt neutron generation time and a parameter in fuel temperature reactivity coefficient equation are adjusted using quasilinearization. The influences of the external reactivity disturbance, the number and frequency of measurements and the measurement noise level on the method accuracy and rate of convergence are analysed through simulation. Procedures for the design of the identification experiments are suggested. The method proved to be very effective for low level noise measurements. (Author) [pt

  20. Locally supersymmetric D=3 non-linear sigma models

    International Nuclear Information System (INIS)

    Wit, B. de; Tollsten, A.K.; Nicolai, H.

    1993-01-01

    We study non-linear sigma models with N local supersymmetries in three space-time dimensions. For N=1 and 2 the target space of these models is riemannian or Kaehler, respectively. All N>2 theories are associated with Einstein spaces. For N=3 the target space is quaternionic, while for N=4 it generally decomposes, into two separate quaternionic spaces, associated with inequivalent supermultiplets. For N=5, 6, 8 there is a unique (symmetric) space for any given number of supermultiplets. Beyond that there are only theories based on a single supermultiplet for N=9, 10, 12 and 16, associated with coset spaces with the exceptional isometry groups F 4(-20) , E 6(-14) , E 7(-5) and E 8(+8) , respectively. For N=3 and N ≥ 5 the D=2 theories obtained by dimensional reduction are two-loop finite. (orig.)

  1. Fractional-Order Nonlinear Systems Modeling, Analysis and Simulation

    CERN Document Server

    Petráš, Ivo

    2011-01-01

    "Fractional-Order Nonlinear Systems: Modeling, Analysis and Simulation" presents a study of fractional-order chaotic systems accompanied by Matlab programs for simulating their state space trajectories, which are shown in the illustrations in the book. Description of the chaotic systems is clearly presented and their analysis and numerical solution are done in an easy-to-follow manner. Simulink models for the selected fractional-order systems are also presented. The readers will understand the fundamentals of the fractional calculus, how real dynamical systems can be described using fractional derivatives and fractional differential equations, how such equations can be solved, and how to simulate and explore chaotic systems of fractional order. The book addresses to mathematicians, physicists, engineers, and other scientists interested in chaos phenomena or in fractional-order systems. It can be used in courses on dynamical systems, control theory, and applied mathematics at graduate or postgraduate level. ...

  2. A Non-linear Stochastic Model for an Office Building with Air Infiltration

    DEFF Research Database (Denmark)

    Thavlov, Anders; Madsen, Henrik

    2015-01-01

    This paper presents a non-linear heat dynamic model for a multi-room office building with air infiltration. Several linear and non-linear models, with and without air infiltration, are investigated and compared. The models are formulated using stochastic differential equations and the model...

  3. Nonlinear Modeling of Forced Magnetic Reconnection with Transient Perturbations

    Science.gov (United States)

    Beidler, Matthew T.; Callen, James D.; Hegna, Chris C.; Sovinec, Carl R.

    2017-10-01

    Externally applied 3D magnetic fields in tokamaks can penetrate into the plasma and lead to forced magnetic reconnection, and hence magnetic islands, on resonant surfaces. Analytic theory has been reasonably successful in describing many aspects of this paradigm with regard to describing the time asymptotic-steady state. However, understanding the nonlinear evolution into a low-slip, field-penetrated state, especially how MHD events such as sawteeth and ELMs precipitate this transition, is in its early development. We present nonlinear computations employing the extended-MHD code NIMROD, building on previous work by incorporating a temporally varying external perturbation as a simple model for an MHD event that produces resonant magnetic signals. A parametric series of proof-of-principle computations and accompanying analytical theory characterize the transition into a mode-locked state with an emphasis on detailing the temporal evolution properties. Supported by DOE OFES Grants DE-FG02-92ER54139, DE-FG02-86ER53218, and the U.S. DOE FES Postdoctoral Research program administered by ORISE and managed by ORAU under DOE contract DE-SC0014664.

  4. Electrodynamic soil plate oscillator: Modeling nonlinear mesoscopic elastic behavior and hysteresis in nonlinear acoustic landmine detection

    Science.gov (United States)

    Korman, M. S.; Duong, D. V.; Kalsbeck, A. E.

    2015-10-01

    An apparatus (SPO), designed to study flexural vibrations of a soil loaded plate, consists of a thin circular elastic clamped plate (and cylindrical wall) supporting a vertical soil column. A small magnet attached to the center of the plate is driven by a rigid AC coil (located coaxially below the plate) to complete the electrodynamic soil plate oscillator SPO design. The frequency dependent mechanical impedance Zmech (force / particle velocity, at the plate's center) is inversely proportional to the electrical motional impedance Zmot. Measurements of Zmot are made using the complex output to input response of a Wheatstone bridge that has an identical coil element in one of its legs. Near resonance, measurements of Zmot (with no soil) before and after a slight point mass loading at the center help determine effective mass, spring, damping and coupling constant parameters of the system. "Tuning curve" behavior of real{ Zmot } and imaginary{ Zmot } at successively higher vibration amplitudes of dry sifted masonry sand are measured. They exhibit a decrease "softening" in resonance frequency along with a decrease in the quality Q factor. In soil surface vibration measurements a bilinear hysteresis model predicts the tuning curve shape for this nonlinear mesoscopic elastic SPO behavior - which also models the soil vibration over an actual plastic "inert" VS 1.6 buried landmine. Experiments are performed where a buried 1m cube concrete block supports a 12 inch deep by 30 inch by 30 inch concrete soil box for burying a VS 1.6 in dry sifted masonry sand for on-the-mine and off-the-mine soil vibration experiments. The backbone curve (a plot of the peak amplitude vs. corresponding resonant frequency from a family of tuning curves) exhibits mostly linear behavior for "on target" soil surface vibration measurements of the buried VS 1.6 or drum-like mine simulants for relatively low particle velocities of the soil. Backbone curves for "on target" measurements exhibit

  5. Robust nonlinear control of nuclear reactors under model uncertainty

    International Nuclear Information System (INIS)

    Park, Moon Ghu

    1993-02-01

    A nonlinear model-based control method is developed for the robust control of a nuclear reactor. The nonlinear plant model is used to design a unique control law which covers a wide operating range. The robustness is a crucial factor for the fully automatic control of reactor power due to time-varying, uncertain parameters, and state estimation error, or unmodeled dynamics. A variable structure control (VSC) method is introduced which consists of an adaptive performance specification (fime control) after the tracking error reaches the narrow boundary-layer by a time-optimal control (coarse control). Variable structure control is a powerful method for nonlinear system controller design which has inherent robustness to parameter variations or external disturbances using the known uncertainty bounds, and it requires very low computational efforts. In spite of its desirable properties, conventional VSC presents several important drawbacks that limit its practical applicability. One of the most undesirable phenomena is chattering, which implies extremely high control activity and may excite high-frequency unmodeled dynamics. This problem is due to the neglected actuator time-delay or sampling effects. The problem was partially remedied by replacing chattering control by a smooth control inter-polation in a boundary layer neighnboring a time-varying sliding surface. But, for the nuclear reactor systems which has very fast dynamic response, the sampling effect may destroy the narrow boundary layer when a large uncertainty bound is used. Due to the very short neutron life time, large uncertainty bound leads to the high gain in feedback control. To resolve this problem, a derivative feedback is introduced that gives excellent performance by reducing the uncertainty bound. The stability of tracking error dynamics is guaranteed by the second method of Lyapunov using the two-level uncertainty bounds that are obtained from the knowledge of uncertainty bound and the estimated

  6. Background field method for nonlinear σ-model in stochastic quantization

    International Nuclear Information System (INIS)

    Nakazawa, Naohito; Ennyu, Daiji

    1988-01-01

    We formulate the background field method for the nonlinear σ-model in stochastic quantization. We demonstrate a one-loop calculation for a two-dimensional non-linear σ-model on a general riemannian manifold based on our formulation. The formulation is consistent with the known results in ordinary quantization. As a simple application, we also analyse the multiplicative renormalization of the O(N) nonlinear σ-model. (orig.)

  7. Preisach hysteresis model for non-linear 2D heat diffusion

    International Nuclear Information System (INIS)

    Jancskar, Ildiko; Ivanyi, Amalia

    2006-01-01

    This paper analyzes a non-linear heat diffusion process when the thermal diffusivity behaviour is a hysteretic function of the temperature. Modelling this temperature dependence, the discrete Preisach algorithm as general hysteresis model has been integrated into a non-linear multigrid solver. The hysteretic diffusion shows a heating-cooling asymmetry in character. The presented type of hysteresis speeds up the thermal processes in the modelled systems by a very interesting non-linear way

  8. A novel methodology for energy performance benchmarking of buildings by means of Linear Mixed Effect Model: The case of space and DHW heating of out-patient Healthcare Centres

    International Nuclear Information System (INIS)

    Capozzoli, Alfonso; Piscitelli, Marco Savino; Neri, Francesco; Grassi, Daniele; Serale, Gianluca

    2016-01-01

    Highlights: • 100 Healthcare Centres were analyzed to assess energy consumption reference values. • A novel robust methodology for energy benchmarking process was proposed. • A Linear Mixed Effect estimation Model was used to treat heterogeneous datasets. • A nondeterministic approach was adopted to consider the uncertainty in the process. • The methodology was developed to be upgradable and generalizable to other datasets. - Abstract: The current EU energy efficiency directive 2012/27/EU defines the existing building stocks as one of the most promising potential sector for achieving energy saving. Robust methodologies aimed to quantify the potential reduction of energy consumption for large building stocks need to be developed. To this purpose, a benchmarking analysis is necessary in order to support public planners in determining how well a building is performing, in setting credible targets for improving performance or in detecting abnormal energy consumption. In the present work, a novel methodology is proposed to perform a benchmarking analysis particularly suitable for heterogeneous samples of buildings. The methodology is based on the estimation of a statistical model for energy consumption – the Linear Mixed Effects Model –, so as to account for both the fixed effects shared by all individuals within a dataset and the random effects related to particular groups/classes of individuals in the population. The groups of individuals within the population have been classified by resorting to a supervised learning technique. Under this backdrop, a Monte Carlo simulation is worked out to compute the frequency distribution of annual energy consumption and identify a reference value for each group/class of buildings. The benchmarking analysis was tested for a case study of 100 out-patient Healthcare Centres in Northern Italy, finally resulting in 12 different frequency distributions for space and Domestic Hot Water heating energy consumption, one for

  9. Qualitative analysis of nonlinear incidence rate upon the behaviour of an epidemiological model

    International Nuclear Information System (INIS)

    Li Xiaogui.

    1988-12-01

    Two theorems concerning the solutions of the system of differential equations describing an epidemiological model with nonlinear incidence rate per infective individual are demonstrated. 2 refs, 1 fig

  10. AD Model Builder: using automatic differentiation for statistical inference of highly parameterized complex nonlinear models

    DEFF Research Database (Denmark)

    Fournier, David A.; Skaug, Hans J.; Ancheta, Johnoel

    2011-01-01

    Many criteria for statistical parameter estimation, such as maximum likelihood, are formulated as a nonlinear optimization problem.Automatic Differentiation Model Builder (ADMB) is a programming framework based on automatic differentiation, aimed at highly nonlinear models with a large number...... of such a feature is the generic implementation of Laplace approximation of high-dimensional integrals for use in latent variable models. We also review the literature in which ADMB has been used, and discuss future development of ADMB as an open source project. Overall, the main advantages ofADMB are flexibility...

  11. The Mathematics of Psychotherapy: A Nonlinear Model of Change Dynamics.

    Science.gov (United States)

    Schiepek, Gunter; Aas, Benjamin; Viol, Kathrin

    2016-07-01

    Psychotherapy is a dynamic process produced by a complex system of interacting variables. Even though there are qualitative models of such systems the link between structure and function, between network and network dynamics is still missing. The aim of this study is to realize these links. The proposed model is composed of five state variables (P: problem severity, S: success and therapeutic progress, M: motivation to change, E: emotions, I: insight and new perspectives) interconnected by 16 functions. The shape of each function is modified by four parameters (a: capability to form a trustful working alliance, c: mentalization and emotion regulation, r: behavioral resources and skills, m: self-efficacy and reward expectation). Psychologically, the parameters play the role of competencies or traits, which translate into the concept of control parameters in synergetics. The qualitative model was transferred into five coupled, deterministic, nonlinear difference equations generating the dynamics of each variable as a function of other variables. The mathematical model is able to reproduce important features of psychotherapy processes. Examples of parameter-dependent bifurcation diagrams are given. Beyond the illustrated similarities between simulated and empirical dynamics, the model has to be further developed, systematically tested by simulated experiments, and compared to empirical data.

  12. Parameter estimation in nonlinear models for pesticide degradation

    International Nuclear Information System (INIS)

    Richter, O.; Pestemer, W.; Bunte, D.; Diekkrueger, B.

    1991-01-01

    A wide class of environmental transfer models is formulated as ordinary or partial differential equations. With the availability of fast computers, the numerical solution of large systems became feasible. The main difficulty in performing a realistic and convincing simulation of the fate of a substance in the biosphere is not the implementation of numerical techniques but rather the incomplete data basis for parameter estimation. Parameter estimation is a synonym for statistical and numerical procedures to derive reasonable numerical values for model parameters from data. The classical method is the familiar linear regression technique which dates back to the 18th century. Because it is easy to handle, linear regression has long been established as a convenient tool for analysing relationships. However, the wide use of linear regression has led to an overemphasis of linear relationships. In nature, most relationships are nonlinear and linearization often gives a poor approximation of reality. Furthermore, pure regression models are not capable to map the dynamics of a process. Therefore, realistic models involve the evolution in time (and space). This leads in a natural way to the formulation of differential equations. To establish the link between data and dynamical models, numerical advanced parameter identification methods have been developed in recent years. This paper demonstrates the application of these techniques to estimation problems in the field of pesticide dynamics. (7 refs., 5 figs., 2 tabs.)

  13. Predicting Madura cattle growth curve using non-linear model

    Science.gov (United States)

    Widyas, N.; Prastowo, S.; Widi, T. S. M.; Baliarti, E.

    2018-03-01

    Madura cattle is Indonesian native. It is a composite breed that has undergone hundreds of years of selection and domestication to reach nowadays remarkable uniformity. Crossbreeding has reached the isle of Madura and the Madrasin, a cross between Madura cows and Limousine semen emerged. This paper aimed to compare the growth curve between Madrasin and one type of pure Madura cows, the common Madura cattle (Madura) using non-linear models. Madura cattles are kept traditionally thus reliable records are hardly available. Data were collected from small holder farmers in Madura. Cows from different age classes (5years) were observed, and body measurements (chest girth, body length and wither height) were taken. In total 63 Madura and 120 Madrasin records obtained. Linear model was built with cattle sub-populations and age as explanatory variables. Body weights were estimated based on the chest girth. Growth curves were built using logistic regression. Results showed that within the same age, Madrasin has significantly larger body compared to Madura (plogistic models fit better for Madura and Madrasin cattle data; with the estimated MSE for these models were 39.09 and 759.28 with prediction accuracy of 99 and 92% for Madura and Madrasin, respectively. Prediction of growth curve using logistic regression model performed well in both types of Madura cattle. However, attempts to administer accurate data on Madura cattle are necessary to better characterize and study these cattle.

  14. Analytical model for nonlinear piezoelectric energy harvesting devices

    International Nuclear Information System (INIS)

    Neiss, S; Goldschmidtboeing, F; M Kroener; Woias, P

    2014-01-01

    In this work we propose analytical expressions for the jump-up and jump-down point of a nonlinear piezoelectric energy harvester. In addition, analytical expressions for the maximum power output at optimal resistive load and the 3 dB-bandwidth are derived. So far, only numerical models have been used to describe the physics of a piezoelectric energy harvester. However, this approach is not suitable to quickly evaluate different geometrical designs or piezoelectric materials in the harvester design process. In addition, the analytical expressions could be used to predict the jump-frequencies of a harvester during operation. In combination with a tuning mechanism, this would allow the design of an efficient control algorithm to ensure that the harvester is always working on the oscillator's high energy attractor. (paper)

  15. Onset of the nonlinear regime in unified dark matter models

    International Nuclear Information System (INIS)

    Avelino, P.P.; Beca, L.M.G.; Carvalho, J.P.M. de; Martins, C.J.A.P.; Copeland, E.J.

    2004-01-01

    We discuss the onset of the nonlinear regime in the context of unified dark matter models involving a generalized Chaplygin gas. We show that the transition from dark-matter-like to dark-energy-like behavior will never be smooth. In some regions of space the transition will never take place while in others it may happen sooner or later than naively expected. As a result the linear theory used in previous studies may break down late in the matter dominated era even on large cosmological scales. We study the importance of this effect showing that its magnitude depends on the exact form of the equation of state in the low density regime. We expect that our results will be relevant for other unified dark matter scenarios, particularly those where the quartessence candidate is a perfect fluid

  16. Nonlinear model predictive control for chemical looping process

    Science.gov (United States)

    Joshi, Abhinaya; Lei, Hao; Lou, Xinsheng

    2017-08-22

    A control system for optimizing a chemical looping ("CL") plant includes a reduced order mathematical model ("ROM") that is designed by eliminating mathematical terms that have minimal effect on the outcome. A non-linear optimizer provides various inputs to the ROM and monitors the outputs to determine the optimum inputs that are then provided to the CL plant. An estimator estimates the values of various internal state variables of the CL plant. The system has one structure adapted to control a CL plant that only provides pressure measurements in the CL loops A and B, a second structure adapted to a CL plant that provides pressure measurements and solid levels in both loops A, and B, and a third structure adapted to control a CL plant that provides full information on internal state variables. A final structure provides a neural network NMPC controller to control operation of loops A and B.

  17. Non-Linear Slosh Damping Model Development and Validation

    Science.gov (United States)

    Yang, H. Q.; West, Jeff

    2015-01-01

    Propellant tank slosh dynamics are typically represented by a mechanical model of spring mass damper. This mechanical model is then included in the equation of motion of the entire vehicle for Guidance, Navigation and Control (GN&C) analysis. For a partially-filled smooth wall propellant tank, the critical damping based on classical empirical correlation is as low as 0.05%. Due to this low value of damping, propellant slosh is potential sources of disturbance critical to the stability of launch and space vehicles. It is postulated that the commonly quoted slosh damping is valid only under the linear regime where the slosh amplitude is small. With the increase of slosh amplitude, the critical damping value should also increase. If this nonlinearity can be verified and validated, the slosh stability margin can be significantly improved, and the level of conservatism maintained in the GN&C analysis can be lessened. The purpose of this study is to explore and to quantify the dependence of slosh damping with slosh amplitude. Accurately predicting the extremely low damping value of a smooth wall tank is very challenging for any Computational Fluid Dynamics (CFD) tool. One must resolve thin boundary layers near the wall and limit numerical damping to minimum. This computational study demonstrates that with proper grid resolution, CFD can indeed accurately predict the low damping physics from smooth walls under the linear regime. Comparisons of extracted damping values with experimental data for different tank sizes show very good agreements. Numerical simulations confirm that slosh damping is indeed a function of slosh amplitude. When slosh amplitude is low, the damping ratio is essentially constant, which is consistent with the empirical correlation. Once the amplitude reaches a critical value, the damping ratio becomes a linearly increasing function of the slosh amplitude. A follow-on experiment validated the developed nonlinear damping relationship. This discovery can

  18. Fluctuating Nonlinear Spring Model of Mechanical Deformation of Biological Particles.

    Directory of Open Access Journals (Sweden)

    Olga Kononova

    2016-01-01

    Full Text Available The mechanical properties of virus capsids correlate with local conformational dynamics in the capsid structure. They also reflect the required stability needed to withstand high internal pressures generated upon genome loading and contribute to the success of important events in viral infectivity, such as capsid maturation, genome uncoating and receptor binding. The mechanical properties of biological nanoparticles are often determined from monitoring their dynamic deformations in Atomic Force Microscopy nanoindentation experiments; but a comprehensive theory describing the full range of observed deformation behaviors has not previously been described. We present a new theory for modeling dynamic deformations of biological nanoparticles, which considers the non-linear Hertzian deformation, resulting from an indenter-particle physical contact, and the bending of curved elements (beams modeling the particle structure. The beams' deformation beyond the critical point triggers a dynamic transition of the particle to the collapsed state. This extreme event is accompanied by a catastrophic force drop as observed in the experimental or simulated force (F-deformation (X spectra. The theory interprets fine features of the spectra, including the nonlinear components of the FX-curves, in terms of the Young's moduli for Hertzian and bending deformations, and the structural damage dependent beams' survival probability, in terms of the maximum strength and the cooperativity parameter. The theory is exemplified by successfully describing the deformation dynamics of natural nanoparticles through comparing theoretical curves with experimental force-deformation spectra for several virus particles. This approach provides a comprehensive description of the dynamic structural transitions in biological and artificial nanoparticles, which is essential for their optimal use in nanotechnology and nanomedicine applications.

  19. Core seismic behaviour: linear and non-linear models

    International Nuclear Information System (INIS)

    Bernard, M.; Van Dorsselaere, M.; Gauvain, M.; Jenapierre-Gantenbein, M.

    1981-08-01

    The usual methodology for the core seismic behaviour analysis leads to a double complementary approach: to define a core model to be included in the reactor-block seismic response analysis, simple enough but representative of basic movements (diagrid or slab), to define a finer core model, with basic data issued from the first model. This paper presents the history of the different models of both kinds. The inert mass model (IMM) yielded a first rough diagrid movement. The direct linear model (DLM), without shocks and with sodium as an added mass, let to two different ones: DLM 1 with independent movements of the fuel and radial blanket subassemblies, and DLM 2 with a core combined movement. The non-linear (NLM) ''CORALIE'' uses the same basic modelization (Finite Element Beams) but accounts for shocks. It studies the response of a diameter on flats and takes into account the fluid coupling and the wrapper tube flexibility at the pad level. Damping consists of one modal part of 2% and one part due to shocks. Finally, ''CORALIE'' yields the time-history of the displacements and efforts on the supports, but damping (probably greater than 2%) and fluid-structures interaction are still to be precised. The validation experiments were performed on a RAPSODIE core mock-up on scale 1, in similitude of 1/3 as to SPX 1. The equivalent linear model (ELM) was developed for the SPX 1 reactor-block response analysis and a specified seismic level (SB or SM). It is composed of several oscillators fixed to the diagrid and yields the same maximum displacements and efforts than the NLM. The SPX 1 core seismic analysis with a diagrid input spectrum which corresponds to a 0,1 g group acceleration, has been carried out with these models: some aspects of these calculations are presented here

  20. Bilinear Mixed Effects Models for Dyadic Data

    National Research Council Canada - National Science Library

    Hoff, Peter D

    2003-01-01

    This article discusses the use of a symmetric multiplicative interaction effect to capture certain types of third-order dependence patterns often present in social networks and other dyadic datasets...

  1. Nonlinear Growth Models as Measurement Models: A Second-Order Growth Curve Model for Measuring Potential.

    Science.gov (United States)

    McNeish, Daniel; Dumas, Denis

    2017-01-01

    Recent methodological work has highlighted the promise of nonlinear growth models for addressing substantive questions in the behavioral sciences. In this article, we outline a second-order nonlinear growth model in order to measure a critical notion in development and education: potential. Here, potential is conceptualized as having three components-ability, capacity, and availability-where ability is the amount of skill a student is estimated to have at a given timepoint, capacity is the maximum amount of ability a student is predicted to be able to develop asymptotically, and availability is the difference between capacity and ability at any particular timepoint. We argue that single timepoint measures are typically insufficient for discerning information about potential, and we therefore describe a general framework that incorporates a growth model into the measurement model to capture these three components. Then, we provide an illustrative example using the public-use Early Childhood Longitudinal Study-Kindergarten data set using a Michaelis-Menten growth function (reparameterized from its common application in biochemistry) to demonstrate our proposed model as applied to measuring potential within an educational context. The advantage of this approach compared to currently utilized methods is discussed as are future directions and limitations.

  2. Modelling female fertility traits in beef cattle using linear and non-linear models.

    Science.gov (United States)

    Naya, H; Peñagaricano, F; Urioste, J I

    2017-06-01

    Female fertility traits are key components of the profitability of beef cattle production. However, these traits are difficult and expensive to measure, particularly under extensive pastoral conditions, and consequently, fertility records are in general scarce and somehow incomplete. Moreover, fertility traits are usually dominated by the effects of herd-year environment, and it is generally assumed that relatively small margins are kept for genetic improvement. New ways of modelling genetic variation in these traits are needed. Inspired in the methodological developments made by Prof. Daniel Gianola and co-workers, we assayed linear (Gaussian), Poisson, probit (threshold), censored Poisson and censored Gaussian models to three different kinds of endpoints, namely calving success (CS), number of days from first calving (CD) and number of failed oestrus (FE). For models involving FE and CS, non-linear models overperformed their linear counterparts. For models derived from CD, linear versions displayed better adjustment than the non-linear counterparts. Non-linear models showed consistently higher estimates of heritability and repeatability in all cases (h 2  linear models; h 2  > 0.23 and r > 0.24, for non-linear models). While additive and permanent environment effects showed highly favourable correlations between all models (>0.789), consistency in selecting the 10% best sires showed important differences, mainly amongst the considered endpoints (FE, CS and CD). In consequence, endpoints should be considered as modelling different underlying genetic effects, with linear models more appropriate to describe CD and non-linear models better for FE and CS. © 2017 Blackwell Verlag GmbH.

  3. Neural network modeling of nonlinear systems based on Volterra series extension of a linear model

    Science.gov (United States)

    Soloway, Donald I.; Bialasiewicz, Jan T.

    1992-01-01

    A Volterra series approach was applied to the identification of nonlinear systems which are described by a neural network model. A procedure is outlined by which a mathematical model can be developed from experimental data obtained from the network structure. Applications of the results to the control of robotic systems are discussed.

  4. A simple non-linear model of immune response

    International Nuclear Information System (INIS)

    Gutnikov, Sergei; Melnikov, Yuri

    2003-01-01

    It is still unknown why the adaptive immune response in the natural immune system based on clonal proliferation of lymphocytes requires interaction of at least two different cell types with the same antigen. We present a simple mathematical model illustrating that the system with separate types of cells for antigen recognition and patogen destruction provides more robust adaptive immunity than the system where just one cell type is responsible for both recognition and destruction. The model is over-simplified as we did not have an intention of describing the natural immune system. However, our model provides a tool for testing the proposed approach through qualitative analysis of the immune system dynamics in order to construct more sophisticated models of the immune systems that exist in the living nature. It also opens a possibility to explore specific features of highly non-linear dynamics in nature-inspired computational paradigms like artificial immune systems and immunocomputing . We expect this paper to be of interest not only for mathematicians but also for biologists; therefore we made effort to explain mathematics in sufficient detail for readers without professional mathematical background

  5. FDTD modeling of anisotropic nonlinear optical phenomena in silicon waveguides.

    Science.gov (United States)

    Dissanayake, Chethiya M; Premaratne, Malin; Rukhlenko, Ivan D; Agrawal, Govind P

    2010-09-27

    A deep insight into the inherent anisotropic optical properties of silicon is required to improve the performance of silicon-waveguide-based photonic devices. It may also lead to novel device concepts and substantially extend the capabilities of silicon photonics in the future. In this paper, for the first time to the best of our knowledge, we present a three-dimensional finite-difference time-domain (FDTD) method for modeling optical phenomena in silicon waveguides, which takes into account fully the anisotropy of the third-order electronic and Raman susceptibilities. We show that, under certain realistic conditions that prevent generation of the longitudinal optical field inside the waveguide, this model is considerably simplified and can be represented by a computationally efficient algorithm, suitable for numerical analysis of complex polarization effects. To demonstrate the versatility of our model, we study polarization dependence for several nonlinear effects, including self-phase modulation, cross-phase modulation, and stimulated Raman scattering. Our FDTD model provides a basis for a full-blown numerical simulator that is restricted neither by the single-mode assumption nor by the slowly varying envelope approximation.

  6. Lukasiewicz-Topos Models of Neural Networks, Cell Genome and Interactome Nonlinear Dynamic Models

    CERN Document Server

    Baianu, I C

    2004-01-01

    A categorical and Lukasiewicz-Topos framework for Lukasiewicz Algebraic Logic models of nonlinear dynamics in complex functional systems such as neural networks, genomes and cell interactomes is proposed. Lukasiewicz Algebraic Logic models of genetic networks and signaling pathways in cells are formulated in terms of nonlinear dynamic systems with n-state components that allow for the generalization of previous logical models of both genetic activities and neural networks. An algebraic formulation of variable 'next-state functions' is extended to a Lukasiewicz Topos with an n-valued Lukasiewicz Algebraic Logic subobject classifier description that represents non-random and nonlinear network activities as well as their transformations in developmental processes and carcinogenesis.

  7. Modeling and Analysis of a Nonlinear Age-Structured Model for Tumor Cell Populations with Quiescence

    Science.gov (United States)

    Liu, Zijian; Chen, Jing; Pang, Jianhua; Bi, Ping; Ruan, Shigui

    2018-05-01

    We present a nonlinear first-order hyperbolic partial differential equation model to describe age-structured tumor cell populations with proliferating and quiescent phases at the avascular stage in vitro. The division rate of the proliferating cells is assumed to be nonlinear due to the limitation of the nutrient and space. The model includes a proportion of newborn cells that enter directly the quiescent phase with age zero. This proportion can reflect the effect of treatment by drugs such as erlotinib. The existence and uniqueness of solutions are established. The local and global stabilities of the trivial steady state are investigated. The existence and local stability of the positive steady state are also analyzed. Numerical simulations are performed to verify the results and to examine the impacts of parameters on the nonlinear dynamics of the model.

  8. Strategies for fitting nonlinear ecological models in R, AD Model Builder, and BUGS

    Science.gov (United States)

    Bolker, Benjamin M.; Gardner, Beth; Maunder, Mark; Berg, Casper W.; Brooks, Mollie; Comita, Liza; Crone, Elizabeth; Cubaynes, Sarah; Davies, Trevor; de Valpine, Perry; Ford, Jessica; Gimenez, Olivier; Kéry, Marc; Kim, Eun Jung; Lennert-Cody, Cleridy; Magunsson, Arni; Martell, Steve; Nash, John; Nielson, Anders; Regentz, Jim; Skaug, Hans; Zipkin, Elise

    2013-01-01

    1. Ecologists often use nonlinear fitting techniques to estimate the parameters of complex ecological models, with attendant frustration. This paper compares three open-source model fitting tools and discusses general strategies for defining and fitting models. 2. R is convenient and (relatively) easy to learn, AD Model Builder is fast and robust but comes with a steep learning curve, while BUGS provides the greatest flexibility at the price of speed. 3. Our model-fitting suggestions range from general cultural advice (where possible, use the tools and models that are most common in your subfield) to specific suggestions about how to change the mathematical description of models to make them more amenable to parameter estimation. 4. A companion web site (https://groups.nceas.ucsb.edu/nonlinear-modeling/projects) presents detailed examples of application of the three tools to a variety of typical ecological estimation problems; each example links both to a detailed project report and to full source code and data.

  9. Neural-Based Compensation of Nonlinearities in an Airplane Longitudinal Model with Dynamic-Inversion Control

    Directory of Open Access Journals (Sweden)

    YanBin Liu

    2017-01-01

    Full Text Available The inversion design approach is a very useful tool for the complex multiple-input-multiple-output nonlinear systems to implement the decoupling control goal, such as the airplane model and spacecraft model. In this work, the flight control law is proposed using the neural-based inversion design method associated with the nonlinear compensation for a general longitudinal model of the airplane. First, the nonlinear mathematic model is converted to the equivalent linear model based on the feedback linearization theory. Then, the flight control law integrated with this inversion model is developed to stabilize the nonlinear system and relieve the coupling effect. Afterwards, the inversion control combined with the neural network and nonlinear portion is presented to improve the transient performance and attenuate the uncertain effects on both external disturbances and model errors. Finally, the simulation results demonstrate the effectiveness of this controller.

  10. A Nonlinear Dynamic Inversion Predictor-Based Model Reference Adaptive Controller for a Generic Transport Model

    Science.gov (United States)

    Campbell, Stefan F.; Kaneshige, John T.

    2010-01-01

    Presented here is a Predictor-Based Model Reference Adaptive Control (PMRAC) architecture for a generic transport aircraft. At its core, this architecture features a three-axis, non-linear, dynamic-inversion controller. Command inputs for this baseline controller are provided by pilot roll-rate, pitch-rate, and sideslip commands. This paper will first thoroughly present the baseline controller followed by a description of the PMRAC adaptive augmentation to this control system. Results are presented via a full-scale, nonlinear simulation of NASA s Generic Transport Model (GTM).

  11. Sphalerons of O(3) nonlinear sigma model on a circle

    International Nuclear Information System (INIS)

    Funakubo, Koichi; Otsuki, Shoichiro; Toyoda, Fumihiko.

    1989-09-01

    A series of saddle point solutions of O(3) nonlinear sigma model with symmetry breaking term in 1 + 1 dimensions are obtained by imposing boundary condition either periodic or partially antiperiodic (O(3) sphalerons on a circle). Under the periodic boundary condition, classical features of the O(3) sphalerons are similar to scalar sphalerons of φ 4 model on a circle by Manton and Samols. Under the partially antiperiodic boundary condition, the lowest of the O(3) sphalerons coincides in the limit of infinite spatial domain with the O(3) sphaleron by Mottola and Wipf. In particular, zero and negative modes of them are examined in detail. An estimate of transition rate over the lowest O(3) sphaleron at finite temperature is made, and some remarks on simulating the transition on a lattice are given. One to one correspondence between these O(3) sphalerons on a circle and a series of (possible) classical solutions of SU(2) gauge-Higgs model, to which the electroweak sphaleron S and new sphaleron S* belong, is discussed. (author)

  12. Computational Modeling of Ultrafast Pulse Propagation in Nonlinear Optical Materials

    Science.gov (United States)

    Goorjian, Peter M.; Agrawal, Govind P.; Kwak, Dochan (Technical Monitor)

    1996-01-01

    There is an emerging technology of photonic (or optoelectronic) integrated circuits (PICs or OEICs). In PICs, optical and electronic components are grown together on the same chip. rib build such devices and subsystems, one needs to model the entire chip. Accurate computer modeling of electromagnetic wave propagation in semiconductors is necessary for the successful development of PICs. More specifically, these computer codes would enable the modeling of such devices, including their subsystems, such as semiconductor lasers and semiconductor amplifiers in which there is femtosecond pulse propagation. Here, the computer simulations are made by solving the full vector, nonlinear, Maxwell's equations, coupled with the semiconductor Bloch equations, without any approximations. The carrier is retained in the description of the optical pulse, (i.e. the envelope approximation is not made in the Maxwell's equations), and the rotating wave approximation is not made in the Bloch equations. These coupled equations are solved to simulate the propagation of femtosecond optical pulses in semiconductor materials. The simulations describe the dynamics of the optical pulses, as well as the interband and intraband.

  13. Importance measures in global sensitivity analysis of nonlinear models

    International Nuclear Information System (INIS)

    Homma, Toshimitsu; Saltelli, Andrea

    1996-01-01

    The present paper deals with a new method of global sensitivity analysis of nonlinear models. This is based on a measure of importance to calculate the fractional contribution of the input parameters to the variance of the model prediction. Measures of importance in sensitivity analysis have been suggested by several authors, whose work is reviewed in this article. More emphasis is given to the developments of sensitivity indices by the Russian mathematician I.M. Sobol'. Given that Sobol' treatment of the measure of importance is the most general, his formalism is employed throughout this paper where conceptual and computational improvements of the method are presented. The computational novelty of this study is the introduction of the 'total effect' parameter index. This index provides a measure of the total effect of a given parameter, including all the possible synergetic terms between that parameter and all the others. Rank transformation of the data is also introduced in order to increase the reproducibility of the method. These methods are tested on a few analytical and computer models. The main conclusion of this work is the identification of a sensitivity analysis methodology which is both flexible, accurate and informative, and which can be achieved at reasonable computational cost

  14. Cnoidal waves as solutions of the nonlinear liquid drop model

    International Nuclear Information System (INIS)

    Ludu, Andrei; Sandulescu, Aureliu; Greiner Walter

    1997-01-01

    By introducing in the hydrodynamic model, i.e. in the hydrodynamic equation and the corresponding boundary conditions, the higher order terms in the deviation of the shape, we obtain in the second order the Korteweg de Vries equations (KdV). The same equation is obtained by introducing in the liquid drop model (LDM), i.e. in the kinetic, surface and Coulomb terms, the higher terms in the second order. The KdV equation has the cnoidal waves as steady-state solutions. These waves could describe the small anharmonic vibrations of spherical nuclei up to the solitary waves. The solitons could describe the preformation of clusters on the nuclear surface. We apply this nonlinear liquid drop model to the alpha formation in heavy nuclei. We find an additional minimum in the total energy of such systems, corresponding to the solitons as clusters on the nuclear surface. By introducing the shell effects we choose this minimum to be degenerated with the ground state. The spectroscopic factor is given by ratio of the square amplitudes in the two minima. (authors)

  15. Nonlinear sigma models with compact hyperbolic target spaces

    International Nuclear Information System (INIS)

    Gubser, Steven; Saleem, Zain H.; Schoenholz, Samuel S.; Stoica, Bogdan; Stokes, James

    2016-01-01

    We explore the phase structure of nonlinear sigma models with target spaces corresponding to compact quotients of hyperbolic space, focusing on the case of a hyperbolic genus-2 Riemann surface. The continuum theory of these models can be approximated by a lattice spin system which we simulate using Monte Carlo methods. The target space possesses interesting geometric and topological properties which are reflected in novel features of the sigma model. In particular, we observe a topological phase transition at a critical temperature, above which vortices proliferate, reminiscent of the Kosterlitz-Thouless phase transition in the O(2) model V.L. Berezinskii, Destruction of long-range order in one-dimensional and two-dimensional systems having a continuous symmetry group II. Quantum systems, Sov. Phys. JETP 34 (1972) 610. J.M. Kosterlitz and D.J. Thouless, Ordering, metastability and phase transitions in two-dimensional systems, J. Phys. C 6 (1973) 1181 [http://inspirehep.net/search?p=find+J+%22J.Phys.,C6,1181%22]. . Unlike in the O(2) case, there are many different types of vortices, suggesting a possible analogy to the Hagedorn treatment of statistical mechanics of a proliferating number of hadron species. Below the critical temperature the spins cluster around six special points in the target space known as Weierstrass points. The diversity of compact hyperbolic manifolds suggests that our model is only the simplest example of a broad class of statistical mechanical models whose main features can be understood essentially in geometric terms.

  16. Nonlinear sigma models with compact hyperbolic target spaces

    Energy Technology Data Exchange (ETDEWEB)

    Gubser, Steven [Joseph Henry Laboratories, Princeton University, Princeton, NJ 08544 (United States); Saleem, Zain H. [Department of Physics and Astronomy, University of Pennsylvania,Philadelphia, PA 19104 (United States); National Center for Physics, Quaid-e-Azam University Campus,Islamabad 4400 (Pakistan); Schoenholz, Samuel S. [Department of Physics and Astronomy, University of Pennsylvania,Philadelphia, PA 19104 (United States); Stoica, Bogdan [Walter Burke Institute for Theoretical Physics, California Institute of Technology,452-48, Pasadena, CA 91125 (United States); Stokes, James [Department of Physics and Astronomy, University of Pennsylvania,Philadelphia, PA 19104 (United States)

    2016-06-23

    We explore the phase structure of nonlinear sigma models with target spaces corresponding to compact quotients of hyperbolic space, focusing on the case of a hyperbolic genus-2 Riemann surface. The continuum theory of these models can be approximated by a lattice spin system which we simulate using Monte Carlo methods. The target space possesses interesting geometric and topological properties which are reflected in novel features of the sigma model. In particular, we observe a topological phase transition at a critical temperature, above which vortices proliferate, reminiscent of the Kosterlitz-Thouless phase transition in the O(2) model V.L. Berezinskii, Destruction of long-range order in one-dimensional and two-dimensional systems having a continuous symmetry group II. Quantum systems, Sov. Phys. JETP 34 (1972) 610. J.M. Kosterlitz and D.J. Thouless, Ordering, metastability and phase transitions in two-dimensional systems, J. Phys. C 6 (1973) 1181 [http://inspirehep.net/search?p=find+J+%22J.Phys.,C6,1181%22]. . Unlike in the O(2) case, there are many different types of vortices, suggesting a possible analogy to the Hagedorn treatment of statistical mechanics of a proliferating number of hadron species. Below the critical temperature the spins cluster around six special points in the target space known as Weierstrass points. The diversity of compact hyperbolic manifolds suggests that our model is only the simplest example of a broad class of statistical mechanical models whose main features can be understood essentially in geometric terms.

  17. Robust and fast nonlinear optimization of diffusion MRI microstructure models.

    Science.gov (United States)

    Harms, R L; Fritz, F J; Tobisch, A; Goebel, R; Roebroeck, A

    2017-07-15

    Advances in biophysical multi-compartment modeling for diffusion MRI (dMRI) have gained popularity because of greater specificity than DTI in relating the dMRI signal to underlying cellular microstructure. A large range of these diffusion microstructure models have been developed and each of the popular models comes with its own, often different, optimization algorithm, noise model and initialization strategy to estimate its parameter maps. Since data fit, accuracy and precision is hard to verify, this creates additional challenges to comparability and generalization of results from diffusion microstructure models. In addition, non-linear optimization is computationally expensive leading to very long run times, which can be prohibitive in large group or population studies. In this technical note we investigate the performance of several optimization algorithms and initialization strategies over a few of the most popular diffusion microstructure models, including NODDI and CHARMED. We evaluate whether a single well performing optimization approach exists that could be applied to many models and would equate both run time and fit aspects. All models, algorithms and strategies were implemented on the Graphics Processing Unit (GPU) to remove run time constraints, with which we achieve whole brain dataset fits in seconds to minutes. We then evaluated fit, accuracy, precision and run time for different models of differing complexity against three common optimization algorithms and three parameter initialization strategies. Variability of the achieved quality of fit in actual data was evaluated on ten subjects of each of two population studies with a different acquisition protocol. We find that optimization algorithms and multi-step optimization approaches have a considerable influence on performance and stability over subjects and over acquisition protocols. The gradient-free Powell conjugate-direction algorithm was found to outperform other common algorithms in terms of

  18. A Model Predictive Algorithm for Active Control of Nonlinear Noise Processes

    Directory of Open Access Journals (Sweden)

    Qi-Zhi Zhang

    2005-01-01

    Full Text Available In this paper, an improved nonlinear Active Noise Control (ANC system is achieved by introducing an appropriate secondary source. For ANC system to be successfully implemented, the nonlinearity of the primary path and time delay of the secondary path must be overcome. A nonlinear Model Predictive Control (MPC strategy is introduced to deal with the time delay in the secondary path and the nonlinearity in the primary path of the ANC system. An overall online modeling technique is utilized for online secondary path and primary path estimation. The secondary path is estimated using an adaptive FIR filter, and the primary path is estimated using a Neural Network (NN. The two models are connected in parallel with the two paths. In this system, the mutual disturbances between the operation of the nonlinear ANC controller and modeling of the secondary can be greatly reduced. The coefficients of the adaptive FIR filter and weight vector of NN are adjusted online. Computer simulations are carried out to compare the proposed nonlinear MPC method with the nonlinear Filter-x Least Mean Square (FXLMS algorithm. The results showed that the convergence speed of the proposed nonlinear MPC algorithm is faster than that of nonlinear FXLMS algorithm. For testing the robust performance of the proposed nonlinear ANC system, the sudden changes in the secondary path and primary path of the ANC system are considered. Results indicated that the proposed nonlinear ANC system can rapidly track the sudden changes in the acoustic paths of the nonlinear ANC system, and ensure the adaptive algorithm stable when the nonlinear ANC system is time variable.

  19. Nonlinear time-domain modeling of balanced-armature receivers

    DEFF Research Database (Denmark)

    Jensen, Joe; Agerkvist, Finn T.; Harte, James

    2011-01-01

    Nonlinear distortion added by the loudspeaker in a hearing aid lowers the signal-to-noise ratio and may degrade the hearing aid user's ability to understand speech. The balancedarmature- type loudspeakers, predominantly used in hearing aids, are inherently nonlinear devices, as any displacement...

  20. Sinusoidal velaroidal shell – numerical modelling of the nonlinear ...

    African Journals Online (AJOL)

    The nonlinearity, applied to a sinusoidal velaroidal shell with the inner radius r0, the outer variables radii from 10m to 20m and the number of waves n=8, will give rise to the investigation of its nonlinear buckling resistance. The building material is a high-performant concrete. The investigation emphasizes more on the ...

  1. Neurobiologically Inspired Approaches to Nonlinear Process Control and Modeling

    Science.gov (United States)

    1999-12-31

    incorporates second messenger reaction kinetics and calcium dynamics to represent the nonlinear dynamics and the crucial role of neuromodulation in local...reflex). The dynamic neuromodulation as a mechanism for the nonlinear attenuation is the novel result of this study. Ear- lier simulations have shown

  2. Curvature-induced symmetry breaking in nonlinear Schrodinger models

    DEFF Research Database (Denmark)

    Gaididei, Yuri Borisovich; Mingaleev, S. F.; Christiansen, Peter Leth

    2000-01-01

    We consider a curved chain of nonlinear oscillators and show that the interplay of curvature and nonlinearity leads to a symmetry breaking when an asymmetric stationary state becomes energetically more favorable than a symmetric stationary state. We show that the energy of localized states...

  3. Non-linear scaling of a musculoskeletal model of the lower limb using statistical shape models.

    Science.gov (United States)

    Nolte, Daniel; Tsang, Chui Kit; Zhang, Kai Yu; Ding, Ziyun; Kedgley, Angela E; Bull, Anthony M J

    2016-10-03

    Accurate muscle geometry for musculoskeletal models is important to enable accurate subject-specific simulations. Commonly, linear scaling is used to obtain individualised muscle geometry. More advanced methods include non-linear scaling using segmented bone surfaces and manual or semi-automatic digitisation of muscle paths from medical images. In this study, a new scaling method combining non-linear scaling with reconstructions of bone surfaces using statistical shape modelling is presented. Statistical Shape Models (SSMs) of femur and tibia/fibula were used to reconstruct bone surfaces of nine subjects. Reference models were created by morphing manually digitised muscle paths to mean shapes of the SSMs using non-linear transformations and inter-subject variability was calculated. Subject-specific models of muscle attachment and via points were created from three reference models. The accuracy was evaluated by calculating the differences between the scaled and manually digitised models. The points defining the muscle paths showed large inter-subject variability at the thigh and shank - up to 26mm; this was found to limit the accuracy of all studied scaling methods. Errors for the subject-specific muscle point reconstructions of the thigh could be decreased by 9% to 20% by using the non-linear scaling compared to a typical linear scaling method. We conclude that the proposed non-linear scaling method is more accurate than linear scaling methods. Thus, when combined with the ability to reconstruct bone surfaces from incomplete or scattered geometry data using statistical shape models our proposed method is an alternative to linear scaling methods. Copyright © 2016 The Author. Published by Elsevier Ltd.. All rights reserved.

  4. System Identification for Nonlinear FOPDT Model with Input-Dependent Dead-Time

    DEFF Research Database (Denmark)

    Sun, Zhen; Yang, Zhenyu

    2011-01-01

    An on-line iterative method of system identification for a kind of nonlinear FOPDT system is proposed in the paper. The considered nonlinear FOPDT model is an extension of the standard FOPDT model by means that its dead time depends on the input signal and the other parameters are time dependent....

  5. Application of homotopy-perturbation method to nonlinear population dynamics models

    International Nuclear Information System (INIS)

    Chowdhury, M.S.H.; Hashim, I.; Abdulaziz, O.

    2007-01-01

    In this Letter, the homotopy-perturbation method (HPM) is employed to derive approximate series solutions of nonlinear population dynamics models. The nonlinear models considered are the multispecies Lotka-Volterra equations. The accuracy of this method is examined by comparison with the available exact and the fourth-order Runge-Kutta method (RK4)

  6. CROSS DIFFUSION AND NONLINEAR DIFFUSION PREVENTING BLOW UP IN THE KELLER–SEGEL MODEL

    KAUST Repository

    CARRILLO, JOSÉ ANTONIO; HITTMEIR, SABINE; JÜ NGEL, ANSGAR

    2012-01-01

    A parabolic-parabolic (Patlak-)Keller-Segel model in up to three space dimensions with nonlinear cell diffusion and an additional nonlinear cross-diffusion term is analyzed. The main feature of this model is that there exists a new entropy

  7. Testing the Granger noncausality hypothesis in stationary nonlinear models of unknown functional form

    DEFF Research Database (Denmark)

    Péguin-Feissolle, Anne; Strikholm, Birgit; Teräsvirta, Timo

    In this paper we propose a general method for testing the Granger noncausality hypothesis in stationary nonlinear models of unknown functional form. These tests are based on a Taylor expansion of the nonlinear model around a given point in the sample space. We study the performance of our tests b...

  8. Hidden physics models: Machine learning of nonlinear partial differential equations

    Science.gov (United States)

    Raissi, Maziar; Karniadakis, George Em

    2018-03-01

    While there is currently a lot of enthusiasm about "big data", useful data is usually "small" and expensive to acquire. In this paper, we present a new paradigm of learning partial differential equations from small data. In particular, we introduce hidden physics models, which are essentially data-efficient learning machines capable of leveraging the underlying laws of physics, expressed by time dependent and nonlinear partial differential equations, to extract patterns from high-dimensional data generated from experiments. The proposed methodology may be applied to the problem of learning, system identification, or data-driven discovery of partial differential equations. Our framework relies on Gaussian processes, a powerful tool for probabilistic inference over functions, that enables us to strike a balance between model complexity and data fitting. The effectiveness of the proposed approach is demonstrated through a variety of canonical problems, spanning a number of scientific domains, including the Navier-Stokes, Schrödinger, Kuramoto-Sivashinsky, and time dependent linear fractional equations. The methodology provides a promising new direction for harnessing the long-standing developments of classical methods in applied mathematics and mathematical physics to design learning machines with the ability to operate in complex domains without requiring large quantities of data.

  9. Cutoff effects in O(N) nonlinear sigma models

    International Nuclear Information System (INIS)

    Knechtli, Francesco; Leder, Bjoern; Wolff, Ulli

    2005-01-01

    In the nonlinear O(N) sigma model at N=3 unexpected cutoff effects have been found before with standard discretizations and lattice spacings. Here the situation is analyzed further employing additional data for the step scaling function of the finite volume mass gap at N=3,4,8 and a large N-study of the leading as well as next-to-leading terms in 1/N. The latter exact results are demonstrated to follow Symanzik's form of the asymptotic cutoff dependence. At the same time, when fuzzed with artificial statistical errors and then fitted like the Monte Carlo results, a picture similar to N=3 emerges. We hence cannot conclude a truly anomalous cutoff dependence but only relatively large cutoff effects, where the logarithmic component is important. Their size shrinks at larger N, but the structure remains similar. The large N results are particularly interesting as we here have exact nonperturbative control over an asymptotically free model both in the continuum limit and on the lattice

  10. Cutoff effects in O(N) nonlinear sigma models

    International Nuclear Information System (INIS)

    Knechtli, F.; Wolff, U.; Leder, B.

    2005-06-01

    In the nonlinear O(N) sigma model at N=3 unexpected cutoff effects have been found before with standard discretizations and lattice spacings. Here the situation is analyzed further employing additional data for the step scaling function of the finite volume mass gap at N=3,4,8 and a large N-study of the leading as well as next-to-leading terms in 1/N. The latter exact results are demonstrated to follow Symanzik's form of the asymptotic cutoff dependence. At the same time, when fuzzed with artificial statistical errors and then fitted like the Monte Carlo results, a picture similar to N=3 emerges. We hence cannot conclude a truly anomalous cutoff dependence but only relatively large cutoff effects, where the logarithmic component is important. Their size shrinks at larger N, but the structure remains similar. The large N results are particularly interesting as we here have exact nonperturbative control over an asymptotically free model both in the continuum limit and on the lattice. (orig.)

  11. Fast and accurate modeling of nonlinear pulse propagation in graded-index multimode fibers.

    Science.gov (United States)

    Conforti, Matteo; Mas Arabi, Carlos; Mussot, Arnaud; Kudlinski, Alexandre

    2017-10-01

    We develop a model for the description of nonlinear pulse propagation in multimode optical fibers with a parabolic refractive index profile. It consists of a 1+1D generalized nonlinear Schrödinger equation with a periodic nonlinear coefficient, which can be solved in an extremely fast and efficient way. The model is able to quantitatively reproduce recently observed phenomena like geometric parametric instability and broadband dispersive wave emission. We envisage that our equation will represent a valuable tool for the study of spatiotemporal nonlinear dynamics in the growing field of multimode fiber optics.

  12. A model of nonlinear strain and damage accumulation in polymer composites

    Directory of Open Access Journals (Sweden)

    A. N. Ruslantsev

    2014-01-01

    Full Text Available This paper presents a model to predict a nonlinear strain of the carbon laminate; the model is based on the relations between the theory of laminated plates and the non-linear approximation of deformation curve of unidirectional layer at the shear in the layer plane. The explicit expressions of stiffness and compliance matrices were obtained via multiplying the matrices that correspond to the elastic characteristics by the matrices, considering the non-linear properties of the laminate. The paper suggests an approximation option for the non-linear properties of the layer at the shear using an exponential function. Some considerations on damage accumulation in carbon laminates were made.

  13. Microtubules Nonlinear Models Dynamics Investigations through the exp(−Φ(ξ-Expansion Method Implementation

    Directory of Open Access Journals (Sweden)

    Nur Alam

    2016-02-01

    Full Text Available In this research article, we present exact solutions with parameters for two nonlinear model partial differential equations(PDEs describing microtubules, by implementing the exp(−Φ(ξ-Expansion Method. The considered models, describing highly nonlinear dynamics of microtubules, can be reduced to nonlinear ordinary differential equations. While the first PDE describes the longitudinal model of nonlinear dynamics of microtubules, the second one describes the nonlinear model of dynamics of radial dislocations in microtubules. The acquired solutions are then graphically presented, and their distinct properties are enumerated in respect to the corresponding dynamic behavior of the microtubules they model. Various patterns, including but not limited to regular, singular kink-like, as well as periodicity exhibiting ones, are detected. Being the method of choice herein, the exp(−Φ(ξ-Expansion Method not disappointing in the least, is found and declared highly efficient.

  14. Modeling of Macroeconomics by a Novel Discrete Nonlinear Fractional Dynamical System

    Directory of Open Access Journals (Sweden)

    Zhenhua Hu

    2013-01-01

    Full Text Available We propose a new nonlinear economic system with fractional derivative. According to the Jumarie’s definition of fractional derivative, we obtain a discrete fractional nonlinear economic system. Three variables, the gross domestic production, inflation, and unemployment rate, are considered by this nonlinear system. Based on the concrete macroeconomic data of USA, the coefficients of this nonlinear system are estimated by the method of least squares. The application of discrete fractional economic model with linear and nonlinear structure is shown to illustrate the efficiency of modeling the macroeconomic data with discrete fractional dynamical system. The empirical study suggests that the nonlinear discrete fractional dynamical system can describe the actual economic data accurately and predict the future behavior more reasonably than the linear dynamic system. The method proposed in this paper can be applied to investigate other macroeconomic variables of more states.

  15. A Weakly Nonlinear Model for Kelvin–Helmholtz Instability in Incompressible Fluids

    International Nuclear Information System (INIS)

    Li-Feng, Wang; Wen-Hua, Ye; Zheng-Feng, Fan; Chuang, Xue; Ying-Jun, Li

    2009-01-01

    A weakly nonlinear model is proposed for the Kelvin–Helmholtz instability in two-dimensional incompressible fluids by expanding the perturbation velocity potential to third order. The third-order harmonic generation effects of single-mode perturbation are analyzed, as well as the nonlinear correction to the exponential growth of the fundamental modulation. The weakly nonlinear results are supported by numerical simulations. Density and resonance effects exist in the development of mode coupling. (fundamental areas of phenomenology (including applications))

  16. Null Controllability of a Nonlinear Dissipative System and Application to the Detection of the Incomplete Parameter for a Nonlinear Population Dynamics Model

    Directory of Open Access Journals (Sweden)

    Yacouba Simporé

    2016-01-01

    Full Text Available We first prove a null controllability result for a nonlinear system derived from a nonlinear population dynamics model. In order to tackle the controllability problem we use an adapted Carleman inequality. Next we consider the nonlinear population dynamics model with a source term called the pollution term. In order to obtain information on the pollution term we use the method of sentinel.

  17. A Nonlinear Dynamic Model and Free Vibration Analysis of Deployable Mesh Reflectors

    Science.gov (United States)

    Shi, H.; Yang, B.; Thomson, M.; Fang, H.

    2011-01-01

    This paper presents a dynamic model of deployable mesh reflectors, in which geometric and material nonlinearities of such a space structure are fully described. Then, by linearization around an equilibrium configuration of the reflector structure, a linearized model is obtained. With this linearized model, the natural frequencies and mode shapes of a reflector can be computed. The nonlinear dynamic model of deployable mesh reflectors is verified by using commercial finite element software in numerical simulation. As shall be seen, the proposed nonlinear model is useful for shape (surface) control of deployable mesh reflectors under thermal loads.

  18. Modeling of memristor-based chaotic systems using nonlinear Wiener adaptive filters based on backslash operator

    International Nuclear Information System (INIS)

    Zhao, Yibo; Jiang, Yi; Feng, Jiuchao; Wu, Lifu

    2016-01-01

    Highlights: • A novel nonlinear Wiener adaptive filters based on the backslash operator are proposed. • The identification approach to the memristor-based chaotic systems using the proposed adaptive filters. • The weight update algorithm and convergence characteristics for the proposed adaptive filters are derived. - Abstract: Memristor-based chaotic systems have complex dynamical behaviors, which are characterized as nonlinear and hysteresis characteristics. Modeling and identification of their nonlinear model is an important premise for analyzing the dynamical behavior of the memristor-based chaotic systems. This paper presents a novel nonlinear Wiener adaptive filtering identification approach to the memristor-based chaotic systems. The linear part of Wiener model consists of the linear transversal adaptive filters, the nonlinear part consists of nonlinear adaptive filters based on the backslash operator for the hysteresis characteristics of the memristor. The weight update algorithms for the linear and nonlinear adaptive filters are derived. Final computer simulation results show the effectiveness as well as fast convergence characteristics. Comparing with the adaptive nonlinear polynomial filters, the proposed nonlinear adaptive filters have less identification error.

  19. Sampled-data models for linear and nonlinear systems

    CERN Document Server

    Yuz, Juan I

    2014-01-01

    Sampled-data Models for Linear and Nonlinear Systems provides a fresh new look at a subject with which many researchers may think themselves familiar. Rather than emphasising the differences between sampled-data and continuous-time systems, the authors proceed from the premise that, with modern sampling rates being as high as they are, it is becoming more appropriate to emphasise connections and similarities. The text is driven by three motives: ·      the ubiquity of computers in modern control and signal-processing equipment means that sampling of systems that really evolve continuously is unavoidable; ·      although superficially straightforward, sampling can easily produce erroneous results when not treated properly; and ·      the need for a thorough understanding of many aspects of sampling among researchers and engineers dealing with applications to which they are central. The authors tackle many misconceptions which, although appearing reasonable at first sight, are in fact either p...

  20. Nonlinear model predictive control of a wave energy converter based on differential flatness parameterisation

    Science.gov (United States)

    Li, Guang

    2017-01-01

    This paper presents a fast constrained optimization approach, which is tailored for nonlinear model predictive control of wave energy converters (WEC). The advantage of this approach relies on its exploitation of the differential flatness of the WEC model. This can reduce the dimension of the resulting nonlinear programming problem (NLP) derived from the continuous constrained optimal control of WEC using pseudospectral method. The alleviation of computational burden using this approach helps to promote an economic implementation of nonlinear model predictive control strategy for WEC control problems. The method is applicable to nonlinear WEC models, nonconvex objective functions and nonlinear constraints, which are commonly encountered in WEC control problems. Numerical simulations demonstrate the efficacy of this approach.

  1. Modeling the SAR Signature of Nonlinear Internal Waves

    National Research Council Canada - National Science Library

    Lettvin, Ellen E

    2008-01-01

    Nonlinear Internal Waves are pervasive globally, particularly in coastal waters. The currents and displacements associated with internal waves influence acoustic propagation and underwater navigation, as well as ocean transport and mixing...

  2. A nonlinear inversion for the velocity background and perturbation models

    KAUST Repository

    Wu, Zedong; Alkhalifah, Tariq Ali

    2015-01-01

    Reflected waveform inversion (RWI) provides a method to reduce the nonlinearity of the standard full waveform inversion (FWI) by inverting for the single scattered wavefield obtained using an image. However, current RWI methods usually neglect

  3. Stabilization and Control Models of Systems With Hysteresis Nonlinearities

    Directory of Open Access Journals (Sweden)

    Mihail E. Semenov

    2012-05-01

    Full Text Available Mechanical and economic systems with hysteresis nonlinearities are studied in article. Dissipativity condition of inverted pendulum under the hysteresis control is obtained. The solution of the optimal production strategy problem was found where price has hysteresis behaviour.

  4. The spectral cell method in nonlinear earthquake modeling

    Science.gov (United States)

    Giraldo, Daniel; Restrepo, Doriam

    2017-12-01

    This study examines the applicability of the spectral cell method (SCM) to compute the nonlinear earthquake response of complex basins. SCM combines fictitious-domain concepts with the spectral-version of the finite element method to solve the wave equations in heterogeneous geophysical domains. Nonlinear behavior is considered by implementing the Mohr-Coulomb and Drucker-Prager yielding criteria. We illustrate the performance of SCM with numerical examples of nonlinear basins exhibiting physically and computationally challenging conditions. The numerical experiments are benchmarked with results from overkill solutions, and using MIDAS GTS NX, a finite element software for geotechnical applications. Our findings show good agreement between the two sets of results. Traditional spectral elements implementations allow points per wavelength as low as PPW = 4.5 for high-order polynomials. Our findings show that in the presence of nonlinearity, high-order polynomials (p ≥ 3) require mesh resolutions above of PPW ≥ 10 to ensure displacement errors below 10%.

  5. Strategies for fitting nonlinear ecological models in R, AD Model Builder, and BUGS

    DEFF Research Database (Denmark)

    Bolker, B.M.; Gardner, B.; Maunder, M.

    2013-01-01

    Ecologists often use nonlinear fitting techniques to estimate the parameters of complex ecological models, with attendant frustration. This paper compares three open-source model fitting tools and discusses general strategies for defining and fitting models. R is convenient and (relatively) easy...... to learn, AD Model Builder is fast and robust but comes with a steep learning curve, while BUGS provides the greatest flexibility at the price of speed. Our model-fitting suggestions range from general cultural advice (where possible, use the tools and models that are most common in your subfield...

  6. NSLS-II: Nonlinear Model Calibration for Synchrotrons

    Energy Technology Data Exchange (ETDEWEB)

    Bengtsson, J.

    2010-10-08

    This tech note is essentially a summary of a lecture we delivered to the Acc. Phys. Journal Club Apr, 2010. However, since the estimated accuracy of these methods has been naive and misleading in the field of particle accelerators, i.e., ignores the impact of noise, we will elaborate on this in some detail. A prerequisite for a calibration of the nonlinear Hamiltonian is that the quadratic part has been understood, i.e., that the linear optics for the real accelerator has been calibrated. For synchrotron light source operations, this problem has been solved by the interactive LOCO technique/tool (Linear Optics from Closed Orbits). Before that, in the context of hadron accelerators, it has been done by signal processing of turn-by-turn BPM data. We have outlined how to make a basic calibration of the nonlinear model for synchrotrons. In particular, we have shown how this was done for LEAR, CERN (antiprotons) in the mid-80s. Specifically, our accuracy for frequency estimation was {approx} 1 x 10{sup -5} for 1024 turns (to calibrate the linear optics) and {approx} 1 x 10{sup -4} for 256 turns for tune footprint and betatron spectrum. For a comparison, the estimated tune footprint for stable beam for NSLS-II is {approx}0.1. Since the transverse damping time is {approx}20 msec, i.e., {approx}4,000 turns. There is no fundamental difference for: antiprotons, protons, and electrons in this case. Because the estimated accuracy for these methods in the field of particle accelerators has been naive, i.e., ignoring the impact of noise, we have also derived explicit formula, from first principles, for a quantitative statement. For e.g. N = 256 and 5% noise we obtain {delta}{nu} {approx} 1 x 10{sup -5}. A comparison with the state-of-the-arts in e.g. telecomm and electrical engineering since the 60s is quite revealing. For example, Kalman filter (1960), crucial for the: Ranger, Mariner, and Apollo (including the Lunar Module) missions during the 60s. Or Claude Shannon et al

  7. NSLS-II: Nonlinear Model Calibration for Synchrotrons

    International Nuclear Information System (INIS)

    Bengtsson, J.

    2010-01-01

    This tech note is essentially a summary of a lecture we delivered to the Acc. Phys. Journal Club Apr, 2010. However, since the estimated accuracy of these methods has been naive and misleading in the field of particle accelerators, i.e., ignores the impact of noise, we will elaborate on this in some detail. A prerequisite for a calibration of the nonlinear Hamiltonian is that the quadratic part has been understood, i.e., that the linear optics for the real accelerator has been calibrated. For synchrotron light source operations, this problem has been solved by the interactive LOCO technique/tool (Linear Optics from Closed Orbits). Before that, in the context of hadron accelerators, it has been done by signal processing of turn-by-turn BPM data. We have outlined how to make a basic calibration of the nonlinear model for synchrotrons. In particular, we have shown how this was done for LEAR, CERN (antiprotons) in the mid-80s. Specifically, our accuracy for frequency estimation was ∼ 1 x 10 -5 for 1024 turns (to calibrate the linear optics) and ∼ 1 x 10 -4 for 256 turns for tune footprint and betatron spectrum. For a comparison, the estimated tune footprint for stable beam for NSLS-II is ∼0.1. Since the transverse damping time is ∼20 msec, i.e., ∼4,000 turns. There is no fundamental difference for: antiprotons, protons, and electrons in this case. Because the estimated accuracy for these methods in the field of particle accelerators has been naive, i.e., ignoring the impact of noise, we have also derived explicit formula, from first principles, for a quantitative statement. For e.g. N = 256 and 5% noise we obtain (delta)ν ∼ 1 x 10 -5 . A comparison with the state-of-the-arts in e.g. telecomm and electrical engineering since the 60s is quite revealing. For example, Kalman filter (1960), crucial for the: Ranger, Mariner, and Apollo (including the Lunar Module) missions during the 60s. Or Claude Shannon et al since the 40s for that matter. Conclusion: what

  8. Nonlinear economic dynamics and financial modelling: essays in honour of Carl Chiarella

    NARCIS (Netherlands)

    Dieci, R.; He, X.Z.; Hommes, C.

    2014-01-01

    This book reflects the state of the art on nonlinear economic dynamics, financial market modelling and quantitative finance. It contains eighteen papers with topics ranging from disequilibrium macroeconomics, monetary dynamics, monopoly, financial market and limit order market models with boundedly

  9. Study of the critical behavior of the O(N) linear and nonlinear sigma models

    International Nuclear Information System (INIS)

    Graziani, F.R.

    1983-01-01

    A study of the large N behavior of both the O(N) linear and nonlinear sigma models is presented. The purpose is to investigate the relationship between the disordered (ordered) phase of the linear and nonlinear sigma models. Utilizing operator product expansions and stability analyses, it is shown that for 2 - (lambda/sub R/(M) is the dimensionless renormalized quartic coupling and lambda* is the IR fixed point) limit of the linear sigma model which yields the nonlinear sigma model. It is also shown that stable large N linear sigma models with lambda 0) and nonlinear models are trivial. This result (i.e., triviality) is well known but only for one and two component models. Interestingly enough, the lambda< d = 4 linear sigma model remains nontrivial and tachyonic free

  10. Mathematical models of non-linear phenomena, processes and systems: from molecular scale to planetary atmosphere

    CERN Document Server

    2013-01-01

    This book consists of twenty seven chapters, which can be divided into three large categories: articles with the focus on the mathematical treatment of non-linear problems, including the methodologies, algorithms and properties of analytical and numerical solutions to particular non-linear problems; theoretical and computational studies dedicated to the physics and chemistry of non-linear micro-and nano-scale systems, including molecular clusters, nano-particles and nano-composites; and, papers focused on non-linear processes in medico-biological systems, including mathematical models of ferments, amino acids, blood fluids and polynucleic chains.

  11. An efficient flexible-order model for 3D nonlinear water waves

    DEFF Research Database (Denmark)

    Engsig-Karup, Allan Peter; Bingham, Harry B.; Lindberg, Ole

    2009-01-01

    The flexible-order, finite difference based fully nonlinear potential flow model described in [H.B. Bingham, H. Zhang, On the accuracy of finite difference solutions for nonlinear water waves, J. Eng. Math. 58 (2007) 211-228] is extended to three dimensions (3D). In order to obtain an optimal......, robustness and energy conservation are presented together with demonstrations of grid independent iteration count and optimal scaling of the solution effort. Calculations are made for 3D nonlinear wave problems for steep nonlinear waves and a shoaling problem which show good agreement with experimental...

  12. A Monte Carlo Investigation of the Box-Cox Model and a Nonlinear Least Squares Alternative.

    OpenAIRE

    Showalter, Mark H

    1994-01-01

    This paper reports a Monte Carlo study of the Box-Cox model and a nonlinear least squares alternative. Key results include the following: the transformation parameter in the Box-Cox model appears to be inconsistently estimated in the presence of conditional heteroskedasticity; the constant term in both the Box-Cox and the nonlinear least squares models is poorly estimated in small samples; conditional mean forecasts tend to underestimate their true value in the Box-Cox model when the transfor...

  13. Non-linear characterisation of the physical model of an ancient masonry bridge

    International Nuclear Information System (INIS)

    Fragonara, L Zanotti; Ceravolo, R; Matta, E; Quattrone, A; De Stefano, A; Pecorelli, M

    2012-01-01

    This paper presents the non-linear investigations carried out on a scaled model of a two-span masonry arch bridge. The model has been built in order to study the effect of the central pile settlement due to riverbank erosion. Progressive damage was induced in several steps by applying increasing settlements at the central pier. For each settlement step, harmonic shaker tests were conducted under different excitation levels, this allowing for the non-linear identification of the progressively damaged system. The shaker tests have been performed at resonance with the modal frequency of the structure, which were determined from a previous linear identification. Estimated non-linearity parameters, which result from the systematic application of restoring force based identification algorithms, can corroborate models to be used in the reassessment of existing structures. The method used for non-linear identification allows monitoring the evolution of non-linear parameters or indicators which can be used in damage and safety assessment.

  14. Applicability of linear and non-linear potential flow models on a Wavestar float

    DEFF Research Database (Denmark)

    Bozonnet, Pauline; Dupin, Victor; Tona, Paolino

    2017-01-01

    as a model based on non-linear potential flow theory and weakscatterer hypothesis are successively considered. Simple tests, such as dip tests, decay tests and captive tests enable to highlight the improvements obtained with the introduction of nonlinearities. Float motion under wave actions and without...... control action, limited to small amplitude motion with a single float, is well predicted by the numerical models, including the linear one. Still, float velocity is better predicted by accounting for non-linear hydrostatic and Froude-Krylov forces.......Numerical models based on potential flow theory, including different types of nonlinearities are compared and validated against experimental data for the Wavestar wave energy converter technology. Exact resolution of the rotational motion, non-linear hydrostatic and Froude-Krylov forces as well...

  15. Efficient Estimation of Non-Linear Dynamic Panel Data Models with Application to Smooth Transition Models

    DEFF Research Database (Denmark)

    Gørgens, Tue; Skeels, Christopher L.; Wurtz, Allan

    This paper explores estimation of a class of non-linear dynamic panel data models with additive unobserved individual-specific effects. The models are specified by moment restrictions. The class includes the panel data AR(p) model and panel smooth transition models. We derive an efficient set...... of moment restrictions for estimation and apply the results to estimation of panel smooth transition models with fixed effects, where the transition may be determined endogenously. The performance of the GMM estimator, both in terms of estimation precision and forecasting performance, is examined in a Monte...

  16. Nonlinear dynamics and modelling of various wooden toys with impact and friction

    NARCIS (Netherlands)

    Leine, R.I.; Campen, van D.H.; Glocker, C.

    2003-01-01

    In this paper, we study bifurcations in systems with impact and friction, modeled with a rigid multibody approach. Knowledge from the field of nonlinear dynamics is therefore combined with theory from the field of non-smooth mechanics. We study the nonlinear dynamics of three commercial wooden toys.

  17. Nonlinear modeling of a rotational MR damper via an enhanced Bouc–Wen model

    International Nuclear Information System (INIS)

    Miah, Mohammad S; Chatzi, Eleni N; Dertimanis, Vasilis K; Weber, Felix

    2015-01-01

    The coupling of magnetorheological (MR) dampers with semi-active control schemes has proven to be an effective and failsafe approach for vibration mitigation of low-damped structures. However, due to the nonlinearities inherently relating to such damping devices, the characterization of the associated nonlinear phenomena is still a challenging task. Herein, an enhanced phenomenological modeling approach is proposed for the description of a rotational-type MR damper, which comprises a modified Bouc–Wen model coupled with an appropriately selected sigmoid function. In a first step, parameter optimization is performed on the basis of individual models in an effort to approximate the experimentally observed response for varying current levels and actuator force characteristics. In a second step, based on the previously identified parameters, a generalized best-fit model is proposed by performing a regression analysis. Finally, model validation is carried out via implementation on different sets of experimental data. The proposed model indeed renders an improved representation of the actually observed nonlinear behavior of the tested rotational MR damper. (paper)

  18. PRESS-based EFOR algorithm for the dynamic parametrical modeling of nonlinear MDOF systems

    Science.gov (United States)

    Liu, Haopeng; Zhu, Yunpeng; Luo, Zhong; Han, Qingkai

    2017-09-01

    In response to the identification problem concerning multi-degree of freedom (MDOF) nonlinear systems, this study presents the extended forward orthogonal regression (EFOR) based on predicted residual sums of squares (PRESS) to construct a nonlinear dynamic parametrical model. The proposed parametrical model is based on the non-linear autoregressive with exogenous inputs (NARX) model and aims to explicitly reveal the physical design parameters of the system. The PRESS-based EFOR algorithm is proposed to identify such a model for MDOF systems. By using the algorithm, we built a common-structured model based on the fundamental concept of evaluating its generalization capability through cross-validation. The resulting model aims to prevent over-fitting with poor generalization performance caused by the average error reduction ratio (AERR)-based EFOR algorithm. Then, a functional relationship is established between the coefficients of the terms and the design parameters of the unified model. Moreover, a 5-DOF nonlinear system is taken as a case to illustrate the modeling of the proposed algorithm. Finally, a dynamic parametrical model of a cantilever beam is constructed from experimental data. Results indicate that the dynamic parametrical model of nonlinear systems, which depends on the PRESS-based EFOR, can accurately predict the output response, thus providing a theoretical basis for the optimal design of modeling methods for MDOF nonlinear systems.

  19. On the Nonlinear Structural Analysis of Wind Turbine Blades using Reduced Degree-of-Freedom Models

    DEFF Research Database (Denmark)

    Holm-Jørgensen, Kristian; Larsen, Jesper Winther; Nielsen, Søren R.K.

    2008-01-01

    , modelling geometrical and inertial nonlinear couplings in the fundamental flap and edge direction. The purpose of this article is to examine the applicability of such a reduced-degree-of-freedom model in predicting the nonlinear response and stability of a blade by comparison to a full model based...... on a nonlinear co-rotating FE formulation. By use of the reduced-degree-of-freedom model it is shown that under strong resonance excitation of the fundamental flap or edge modes, significant energy is transferred to higher modes due to parametric or nonlinear coupling terms, which influence the response...... of the small number of included modes. The qualitative erratic response and stability prediction of the reduced order models take place at frequencies slightly above normal operation. However, for normal operation of the wind turbine without resonance excitation 4 modes in the reduced-degree-of-freedom model...

  20. Model-based nonlinear control of hydraulic servo systems: Challenges, developments and perspectives

    Science.gov (United States)

    Yao, Jianyong

    2018-06-01

    Hydraulic servo system plays a significant role in industries, and usually acts as a core point in control and power transmission. Although linear theory-based control methods have been well established, advanced controller design methods for hydraulic servo system to achieve high performance is still an unending pursuit along with the development of modern industry. Essential nonlinearity is a unique feature and makes model-based nonlinear control more attractive, due to benefit from prior knowledge of the servo valve controlled hydraulic system. In this paper, a discussion for challenges in model-based nonlinear control, latest developments and brief perspectives of hydraulic servo systems are presented: Modelling uncertainty in hydraulic system is a major challenge, which includes parametric uncertainty and time-varying disturbance; some specific requirements also arise ad hoc difficulties such as nonlinear friction during low velocity tracking, severe disturbance, periodic disturbance, etc.; to handle various challenges, nonlinear solutions including parameter adaptation, nonlinear robust control, state and disturbance observation, backstepping design and so on, are proposed and integrated, theoretical analysis and lots of applications reveal their powerful capability to solve pertinent problems; and at the end, some perspectives and associated research topics (measurement noise, constraints, inner valve dynamics, input nonlinearity, etc.) in nonlinear hydraulic servo control are briefly explored and discussed.

  1. Calibration of the Nonlinear Accelerator Model at the Diamond Storage Ring

    CERN Document Server

    Bartolini, Riccardo; Rowland, James; Martin, Ian; Schmidt, Frank

    2010-01-01

    The correct implementation of the nonlinear ring model is crucial to achieve the top performance of a synchrotron light source. Several dynamics quantities can be used to compare the real machine with the model and eventually to correct the accelerator. Most of these methods are based on the analysis of turn-by-turn data of excited betatron oscillations. We present the experimental results of the campaign of measurements carried out at the Diamond. A combination of Frequency Map Analysis (FMA) and detuning with momentum measurements has allowed a precise calibration of the nonlinear model capable of reproducing the nonlinear beam dynamics in the storage ring

  2. Nonlinear dynamics approach of modeling the bifurcation for aircraft wing flutter in transonic speed

    DEFF Research Database (Denmark)

    Matsushita, Hiroshi; Miyata, T.; Christiansen, Lasse Engbo

    2002-01-01

    The procedure of obtaining the two-degrees-of-freedom, finite dimensional. nonlinear mathematical model. which models the nonlinear features of aircraft flutter in transonic speed is reported. The model enables to explain every feature of the transonic flutter data of the wind tunnel tests...... conducted at National Aerospace Laboratory in Japan for a high aspect ratio wing. It explains the nonlinear features of the transonic flutter such as the subcritical Hopf bifurcation of a limit cycle oscillation (LCO), a saddle-node bifurcation, and an unstable limit cycle as well as a normal (linear...

  3. A Comparison Between Mıcrosoft Excel Solver and Ncss, Spss Routines for Nonlinear Regression Models

    Directory of Open Access Journals (Sweden)

    Didem Tetik Küçükelçi

    2018-02-01

    Full Text Available In this study we have tried to compare the results obtained by Microsoft Excel Solver program with those of NCSS and SPSS in some nonlinear regression models. We fit some nonlinear models to data present in http//itl.nist.gov/div898/strd/nls/nls_main.shtml by the three packages. Although EXCEL did not succeed as well as the other packages, we conclude that Microsoft Excel Solver provides us a cheaper and a more interactive way of studying nonlinear models.

  4. Nonlinear Kalman filtering in affine term structure models

    DEFF Research Database (Denmark)

    Christoffersen, Peter; Dorion, Christian; Jacobs, Kris

    2014-01-01

    The extended Kalman filter, which linearizes the relationship between security prices and state variables, is widely used in fixed-income applications. We investigate whether the unscented Kalman filter should be used to capture nonlinearities and compare the performance of the Kalman filter...... with that of the particle filter. We analyze the cross section of swap rates, which are mildly nonlinear in the states, and cap prices, which are highly nonlinear. When caps are used to filter the states, the unscented Kalman filter significantly outperforms its extended counterpart. The unscented Kalman filter also...... performs well when compared with the much more computationally intensive particle filter. These findings suggest that the unscented Kalman filter may be a good approach for a variety of problems in fixed-income pricing....

  5. Nonlinear propagation in ultrasonic fields: measurements, modelling and harmonic imaging.

    Science.gov (United States)

    Humphrey, V F

    2000-03-01

    In high amplitude ultrasonic fields, such as those used in medical ultrasound, nonlinear propagation can result in waveform distortion and the generation of harmonics of the initial frequency. In the nearfield of a transducer this process is complicated by diffraction effects associated with the source. The results of a programme to study the nonlinear propagation in the fields of circular, focused and rectangular transducers are described, and comparisons made with numerical predictions obtained using a finite difference solution to the Khokhlov-Zabolotskaya-Kuznetsov (or KZK) equation. These results are extended to consider nonlinear propagation in tissue-like media and the implications for ultrasonic measurements and ultrasonic heating are discussed. The narrower beamwidths and reduced side-lobe levels of the harmonic beams are illustrated and the use of harmonics to form diagnostic images with improved resolution is described.

  6. The influence of noise on nonlinear time series detection based on Volterra-Wiener-Korenberg model

    Energy Technology Data Exchange (ETDEWEB)

    Lei Min [State Key Laboratory of Vibration, Shock and Noise, Shanghai Jiao Tong University, Shanghai 200030 (China)], E-mail: leimin@sjtu.edu.cn; Meng Guang [State Key Laboratory of Vibration, Shock and Noise, Shanghai Jiao Tong University, Shanghai 200030 (China)

    2008-04-15

    This paper studies the influence of noises on Volterra-Wiener-Korenberg (VWK) nonlinear test model. Our numerical results reveal that different types of noises lead to different behavior of VWK model detection. For dynamic noise, it is difficult to distinguish chaos from nonchaotic but nonlinear determinism. For time series, measure noise has no impact on chaos determinism detection. This paper also discusses various behavior of VWK model detection with surrogate data for different noises.

  7. Improved Polynomial Fuzzy Modeling and Controller with Stability Analysis for Nonlinear Dynamical Systems

    OpenAIRE

    Hamed Kharrati; Sohrab Khanmohammadi; Witold Pedrycz; Ghasem Alizadeh

    2012-01-01

    This study presents an improved model and controller for nonlinear plants using polynomial fuzzy model-based (FMB) systems. To minimize mismatch between the polynomial fuzzy model and nonlinear plant, the suitable parameters of membership functions are determined in a systematic way. Defining an appropriate fitness function and utilizing Taylor series expansion, a genetic algorithm (GA) is used to form the shape of membership functions in polynomial forms, which are afterwards used in fuzzy m...

  8. A Nonlinear Ship Manoeuvering Model: Identification and adaptive control with experiments for a model ship

    Directory of Open Access Journals (Sweden)

    Roger Skjetne

    2004-01-01

    Full Text Available Complete nonlinear dynamic manoeuvering models of ships, with numerical values, are hard to find in the literature. This paper presents a modeling, identification, and control design where the objective is to manoeuver a ship along desired paths at different velocities. Material from a variety of references have been used to describe the ship model, its difficulties, limitations, and possible simplifications for the purpose of automatic control design. The numerical values of the parameters in the model is identified in towing tests and adaptive manoeuvering experiments for a small ship in a marine control laboratory.

  9. Instantaneous nonlinear assessment of complex cardiovascular dynamics by Laguerre-Volterra point process models.

    Science.gov (United States)

    Valenza, Gaetano; Citi, Luca; Barbieri, Riccardo

    2013-01-01

    We report an exemplary study of instantaneous assessment of cardiovascular dynamics performed using point-process nonlinear models based on Laguerre expansion of the linear and nonlinear Wiener-Volterra kernels. As quantifiers, instantaneous measures such as high order spectral features and Lyapunov exponents can be estimated from a quadratic and cubic autoregressive formulation of the model first order moment, respectively. Here, these measures are evaluated on heartbeat series coming from 16 healthy subjects and 14 patients with Congestive Hearth Failure (CHF). Data were gathered from the on-line repository PhysioBank, which has been taken as landmark for testing nonlinear indices. Results show that the proposed nonlinear Laguerre-Volterra point-process methods are able to track the nonlinear and complex cardiovascular dynamics, distinguishing significantly between CHF and healthy heartbeat series.

  10. Anti-symmetrically fused model and non-linear integral equations in the three-state Uimin-Sutherland model

    International Nuclear Information System (INIS)

    Fujii, Akira; Kluemper, Andreas

    1999-01-01

    We derive the non-linear integral equations determining the free energy of the three-state pure bosonic Uimin-Sutherland model. In order to find a complete set of auxiliary functions, the anti-symmetric fusion procedure is utilized. We solve the non-linear integral equations numerically and see that the low-temperature behavior coincides with that predicted by conformal field theory. The magnetization and magnetic susceptibility are also calculated by means of the non-linear integral equation

  11. Finite element modeling of nonlinear piezoelectric energy harvesters with magnetic interaction

    International Nuclear Information System (INIS)

    Upadrashta, Deepesh; Yang, Yaowen

    2015-01-01

    Piezoelectric energy harvesting from ambient vibrations is a potential technology for powering wireless sensors and low power electronic devices. The conventional linear harvesters suffer from narrow operational bandwidth. Many attempts have been made especially using the magnetic interaction to broaden the bandwidth of harvesters. The finite element (FE) modeling has been used only for analyzing the linear harvesters in the literature. The main difficulties in extending the FE modeling to analyze the nonlinear harvesters involving magnetic interaction are developing the mesh needed for magnetic interaction in dynamic problems and the high demand on computational resource needed for solving the coupled electrical–mechanical–magnetic problem. In this paper, an innovative method is proposed to model the magnetic interaction without inclusion of the magnetic module. The magnetic force is modeled using the nonlinear spring element available in ANSYS finite element analysis (FEA) package, thus simplifying the simulation of nonlinear piezoelectric energy harvesters as an electromechanically coupled problem. Firstly, an FE model of a monostable nonlinear harvester with cantilever configuration is developed and the results are validated with predictions from the theoretical model. Later, the proposed technique of FE modeling is extended to a complex 2-degree of freedom nonlinear energy harvester for which an accurate analytical model is difficult to derive. The performance predictions from FEA are compared with the experimental results. It is concluded that the proposed modeling technique is able to accurately analyze the behavior of nonlinear harvesters with magnetic interaction. (paper)

  12. Symbolic-computation study of the perturbed nonlinear Schrodinger model in inhomogeneous optical fibers

    International Nuclear Information System (INIS)

    Tian Bo; Gao Yitian

    2005-01-01

    A realistic, inhomogeneous fiber in the optical communication systems can be described by the perturbed nonlinear Schrodinger model (also named as the normalized nonlinear Schrodinger model with periodically varying coefficients, dispersion managed nonlinear Schrodinger model or nonlinear Schrodinger model with variable coefficients). Hereby, we extend to this model a direct method, perform symbolic computation and obtain two families of the exact, analytic bright-solitonic solutions, with or without the chirp respectively. The parameters addressed include the shape of the bright soliton, soliton amplitude, inverse width of the soliton, chirp, frequency, center of the soliton and center of the phase of the soliton. Of optical and physical interests, we discuss some previously-published special cases of our solutions. Those solutions could help the future studies on the optical communication systems. ms

  13. Robust model predictive control for constrained continuous-time nonlinear systems

    Science.gov (United States)

    Sun, Tairen; Pan, Yongping; Zhang, Jun; Yu, Haoyong

    2018-02-01

    In this paper, a robust model predictive control (MPC) is designed for a class of constrained continuous-time nonlinear systems with bounded additive disturbances. The robust MPC consists of a nonlinear feedback control and a continuous-time model-based dual-mode MPC. The nonlinear feedback control guarantees the actual trajectory being contained in a tube centred at the nominal trajectory. The dual-mode MPC is designed to ensure asymptotic convergence of the nominal trajectory to zero. This paper extends current results on discrete-time model-based tube MPC and linear system model-based tube MPC to continuous-time nonlinear model-based tube MPC. The feasibility and robustness of the proposed robust MPC have been demonstrated by theoretical analysis and applications to a cart-damper springer system and a one-link robot manipulator.

  14. New analytical solutions for nonlinear physical models of the ...

    Indian Academy of Sciences (India)

    In mathematical physics, we studied two complex systems, the Maccari system and the coupled Higgs field equation. We construct sufficient exact solutions for nonlinear evolution equations. To study travelling wave solutions, we used a fractional complex transform to convert the particular partial differential equation of ...

  15. Travelling wave solutions to nonlinear physical models by means

    Indian Academy of Sciences (India)

    This paper presents the first integral method to carry out the integration of nonlinear partial differential equations in terms of travelling wave solutions. For illustration, three important equations of mathematical physics are analytically investigated. Through the established first integrals, exact solutions are successfully ...

  16. Collapse arresting in an inhomogeneous quintic nonlinear Schrodinger model

    DEFF Research Database (Denmark)

    Gaididei, Yuri Borisovich; Schjødt-Eriksen, Jens; Christiansen, Peter Leth

    1999-01-01

    Collapse of (1 + 1)-dimensional beams in the inhomogeneous one-dimensional quintic nonlinear Schrodinger equation is analyzed both numerically and analytically. It is shown that in the vicinity of a narrow attractive inhomogeneity, the collapse of beams in which the homogeneous medium would blow up...

  17. Travelling wave solutions to nonlinear physical models by means of ...

    Indian Academy of Sciences (India)

    Abstract. This paper presents the first integral method to carry out the integration of nonlinear ... NPDEs is an important and attractive research area. Not all ... cial types of analytic solutions to understand biological, physical and chemical phenomena ... Thus, based on the qualitative theory of ordinary differential equations.

  18. Nonlinear wave propagation studies, dispersion modeling, and signal parameters correction

    Czech Academy of Sciences Publication Activity Database

    Převorovský, Zdeněk

    ..: ..., 2004, 00. [European Workshop on FP6-AERONEWS /1./. Naples (IT), 13.09.2004-16.09.2004] EU Projects: European Commission(XE) 502927 - AERO-NEWS Institutional research plan: CEZ:AV0Z2076919 Keywords : nodestructive testing * nonlinear elastic wave spectroscopy Subject RIV: BI - Acoustics

  19. Symmetry properties of some nonlinear field theory models

    International Nuclear Information System (INIS)

    Shvachka, A.B.

    1984-01-01

    Various approaches towards the study of symmetry properties of some nonlinear evolution equations as well as possible ways of their computer implementation using the computer algebra systems langage are discussed. Special attention is paid to the method of pseudopotential investigation of formal integrability and isovector method for the equations of balance

  20. PD/PID controller tuning based on model approximations: Model reduction of some unstable and higher order nonlinear models

    Directory of Open Access Journals (Sweden)

    Christer Dalen

    2017-10-01

    Full Text Available A model reduction technique based on optimization theory is presented, where a possible higher order system/model is approximated with an unstable DIPTD model by using only step response data. The DIPTD model is used to tune PD/PID controllers for the underlying possible higher order system. Numerous examples are used to illustrate the theory, i.e. both linear and nonlinear models. The Pareto Optimal controller is used as a reference controller.

  1. Asymptotic behaviour of a nonlinear model for the geographic diffusion of infections diseases

    International Nuclear Information System (INIS)

    Kirane, M.; Kouachi, S.

    1994-01-01

    In this paper a nonlinear diffusion model for the geographical spread of infective diseases is studied. In addition to proving well-posedness of the associated initial-boundary value problem, the large time behaviour is analyzed. (author). 4 refs

  2. A phenomenological constitutive model for the nonlinear viscoelastic responses of biodegradable polymers

    KAUST Repository

    Khan, Kamran; El Sayed, Tamer S.

    2012-01-01

    We formulate a constitutive framework for biodegradable polymers that accounts for nonlinear viscous behavior under regimes with large deformation. The generalized Maxwell model is used to represent the degraded viscoelastic response of a polymer

  3. Heeding the waveform inversion nonlinearity by unwrapping the model and data

    KAUST Repository

    Alkhalifah, Tariq Ali; Choi, Yun Seok

    2012-01-01

    Unlike traveltime inversion, waveform inversion provides relatively higher-resolution inverted models. This feature, however, comes at the cost of introducing complex nonlinearity to the inversion operator complicating the convergence process. We

  4. Dynamical generation of gauge bosons of hidden local symmetries in nonlinear sigma models

    International Nuclear Information System (INIS)

    Koegerler, R.; Lucha, W.; Neufeld, H.; Stremnitzer, H.

    1988-01-01

    We demonstrate how quantum corrections generate a kinetic term for the (at tree-level non-propagating) gauge fields of hidden local symmetries in nonlinear sigma models in four space-time dimensions. (orig.)

  5. Coupled Particle Transport and Pattern Formation in a Nonlinear Leaky-Box Model

    Science.gov (United States)

    Barghouty, A. F.; El-Nemr, K. W.; Baird, J. K.

    2009-01-01

    Effects of particle-particle coupling on particle characteristics in nonlinear leaky-box type descriptions of the acceleration and transport of energetic particles in space plasmas are examined in the framework of a simple two-particle model based on the Fokker-Planck equation in momentum space. In this model, the two particles are assumed coupled via a common nonlinear source term. In analogy with a prototypical mathematical system of diffusion-driven instability, this work demonstrates that steady-state patterns with strong dependence on the magnetic turbulence but a rather weak one on the coupled particles attributes can emerge in solutions of a nonlinearly coupled leaky-box model. The insight gained from this simple model may be of wider use and significance to nonlinearly coupled leaky-box type descriptions in general.

  6. Nonlinear dynamic mechanism of vocal tremor from voice analysis and model simulations

    Science.gov (United States)

    Zhang, Yu; Jiang, Jack J.

    2008-09-01

    Nonlinear dynamic analysis and model simulations are used to study the nonlinear dynamic characteristics of vocal folds with vocal tremor, which can typically be characterized by low-frequency modulation and aperiodicity. Tremor voices from patients with disorders such as paresis, Parkinson's disease, hyperfunction, and adductor spasmodic dysphonia show low-dimensional characteristics, differing from random noise. Correlation dimension analysis statistically distinguishes tremor voices from normal voices. Furthermore, a nonlinear tremor model is proposed to study the vibrations of the vocal folds with vocal tremor. Fractal dimensions and positive Lyapunov exponents demonstrate the evidence of chaos in the tremor model, where amplitude and frequency play important roles in governing vocal fold dynamics. Nonlinear dynamic voice analysis and vocal fold modeling may provide a useful set of tools for understanding the dynamic mechanism of vocal tremor in patients with laryngeal diseases.

  7. An Efficient Reduced-Order Model for the Nonlinear Dynamics of Carbon Nanotubes

    KAUST Repository

    Xu, Tiantian; Younis, Mohammad I.

    2014-01-01

    Because of the inherent nonlinearities involving the behavior of CNTs when excited by electrostatic forces, modeling and simulating their behavior is challenging. The complicated form of the electrostatic force describing the interaction

  8. Nonlinearity measure and internal model control based linearization in anti-windup design

    Energy Technology Data Exchange (ETDEWEB)

    Perev, Kamen [Systems and Control Department, Technical University of Sofia, 8 Cl. Ohridski Blvd., 1756 Sofia (Bulgaria)

    2013-12-18

    This paper considers the problem of internal model control based linearization in anti-windup design. The nonlinearity measure concept is used for quantifying the control system degree of nonlinearity. The linearizing effect of a modified internal model control structure is presented by comparing the nonlinearity measures of the open-loop and closed-loop systems. It is shown that the linearization properties are improved by increasing the control system local feedback gain. However, it is emphasized that at the same time the stability of the system deteriorates. The conflicting goals of stability and linearization are resolved by solving the design problem in different frequency ranges.

  9. Linear and nonlinear modeling of light propagation in hollow-core photonic crystal fiber

    DEFF Research Database (Denmark)

    Roberts, John; Lægsgaard, Jesper

    2009-01-01

    Hollow core photonic crystal fibers (HC-PCFs) find applications which include quantum and non-linear optics, gas detection and short high-intensity laser pulse delivery. Central to most applications is an understanding of the linear and nonlinear optical properties. These require careful modeling....... The intricacies of modeling various forms of HC-PCF are reviewed. An example of linear dispersion engineering, aimed at reducing and flattening the group velocity dispersion, is then presented. Finally, a study of short high intensity pulse delivery using HC-PCF in both dispersive and nonlinear (solitonic...

  10. Model Predictive Control of a Nonlinear System with Known Scheduling Variable

    DEFF Research Database (Denmark)

    Mirzaei, Mahmood; Poulsen, Niels Kjølstad; Niemann, Hans Henrik

    2012-01-01

    Model predictive control (MPC) of a class of nonlinear systems is considered in this paper. We will use Linear Parameter Varying (LPV) model of the nonlinear system. By taking the advantage of having future values of the scheduling variable, we will simplify state prediction. Consequently...... the control problem of the nonlinear system is simplied into a quadratic programming. Wind turbine is chosen as the case study and we choose wind speed as the scheduling variable. Wind speed is measurable ahead of the turbine, therefore the scheduling variable is known for the entire prediction horizon....

  11. TS Fuzzy Model-Based Controller Design for a Class of Nonlinear Systems Including Nonsmooth Functions

    DEFF Research Database (Denmark)

    Vafamand, Navid; Asemani, Mohammad Hassan; Khayatiyan, Alireza

    2018-01-01

    This paper proposes a novel robust controller design for a class of nonlinear systems including hard nonlinearity functions. The proposed approach is based on Takagi-Sugeno (TS) fuzzy modeling, nonquadratic Lyapunov function, and nonparallel distributed compensation scheme. In this paper, a novel...... criterion, new robust controller design conditions in terms of linear matrix inequalities are derived. Three practical case studies, electric power steering system, a helicopter model and servo-mechanical system, are presented to demonstrate the importance of such class of nonlinear systems comprising...

  12. Nonlinear Prediction Model for Hydrologic Time Series Based on Wavelet Decomposition

    Science.gov (United States)

    Kwon, H.; Khalil, A.; Brown, C.; Lall, U.; Ahn, H.; Moon, Y.

    2005-12-01

    Traditionally forecasting and characterizations of hydrologic systems is performed utilizing many techniques. Stochastic linear methods such as AR and ARIMA and nonlinear ones such as statistical learning theory based tools have been extensively used. The common difficulty to all methods is the determination of sufficient and necessary information and predictors for a successful prediction. Relationships between hydrologic variables are often highly nonlinear and interrelated across the temporal scale. A new hybrid approach is proposed for the simulation of hydrologic time series combining both the wavelet transform and the nonlinear model. The present model employs some merits of wavelet transform and nonlinear time series model. The Wavelet Transform is adopted to decompose a hydrologic nonlinear process into a set of mono-component signals, which are simulated by nonlinear model. The hybrid methodology is formulated in a manner to improve the accuracy of a long term forecasting. The proposed hybrid model yields much better results in terms of capturing and reproducing the time-frequency properties of the system at hand. Prediction results are promising when compared to traditional univariate time series models. An application of the plausibility of the proposed methodology is provided and the results conclude that wavelet based time series model can be utilized for simulating and forecasting of hydrologic variable reasonably well. This will ultimately serve the purpose of integrated water resources planning and management.

  13. A new nonlinear turbulence model based on Partially-Averaged Navier-Stokes Equations

    International Nuclear Information System (INIS)

    Liu, J T; Wu, Y L; Cai, C; Liu, S H; Wang, L Q

    2013-01-01

    Partially-averaged Navier-Stokes (PANS) Model was recognized as a Reynolds-averaged Navier-Stokes (RANS) to direct numerical simulation (DNS) bridging method. PANS model was purported for any filter width-from RANS to DNS. PANS method also shared some similarities with the currently popular URANS (unsteady RANS) method. In this paper, a new PANS model was proposed, which was based on RNG k-ε turbulence model. The Standard and RNG k-ε turbulence model were both isotropic models, as well as PANS models. The sheer stress in those PANS models was solved by linear equation. The linear hypothesis was not accurate in the simulation of complex flow, such as stall phenomenon. The sheer stress here was solved by nonlinear method proposed by Ehrhard. Then, the nonlinear PANS model was set up. The pressure coefficient of the suction side of the NACA0015 hydrofoil was predicted. The result of pressure coefficient agrees well with experimental result, which proves that the nonlinear PANS model can capture the high pressure gradient flow. A low specific centrifugal pump was used to verify the capacity of the nonlinear PANS model. The comparison between the simulation results of the centrifugal pump and Particle Image Velocimetry (PIV) results proves that the nonlinear PANS model can be used in the prediction of complex flow field

  14. Computer-aided Nonlinear Control System Design Using Describing Function Models

    CERN Document Server

    Nassirharand, Amir

    2012-01-01

    A systematic computer-aided approach provides a versatile setting for the control engineer to overcome the complications of controller design for highly nonlinear systems. Computer-aided Nonlinear Control System Design provides such an approach based on the use of describing functions. The text deals with a large class of nonlinear systems without restrictions on the system order, the number of inputs and/or outputs or the number, type or arrangement of nonlinear terms. The strongly software-oriented methods detailed facilitate fulfillment of tight performance requirements and help the designer to think in purely nonlinear terms, avoiding the expedient of linearization which can impose substantial and unrealistic model limitations and drive up the cost of the final product. Design procedures are presented in a step-by-step algorithmic format each step being a functional unit with outputs that drive the other steps. This procedure may be easily implemented on a digital computer with example problems from mecha...

  15. Homogenized global nonlinear constitutive model for RC panels under cyclic loadings

    International Nuclear Information System (INIS)

    Huguet, Miquel; Voldoire, Francois; Kotronis, Panagiotis; Erlicher, Silvano

    2014-01-01

    A new nonlinear stress resultant global constitutive model for RC panels is presented. Concrete damage, concrete stress transfer at cracks and bond-slip stress are the main nonlinear effects identified at the local scale that constitute the basis for the construction of the stress resultant global model through an analytical homogenization technique. The closed form solution is obtained using general functions for the previous phenomena. (authors)

  16. Development of nonperturbative nonlinear optics models including effects of high order nonlinearities and of free electron plasma: Maxwell–Schrödinger equations coupled with evolution equations for polarization effects, and the SFA-like nonlinear optics model

    International Nuclear Information System (INIS)

    Lorin, E; Bandrauk, A D; Lytova, M; Memarian, A

    2015-01-01

    This paper is dedicated to the exploration of non-conventional nonlinear optics models for intense and short electromagnetic fields propagating in a gas. When an intense field interacts with a gas, usual nonlinear optics models, such as cubic nonlinear Maxwell, wave and Schrödinger equations, derived by perturbation theory may become inaccurate or even irrelevant. As a consequence, and to include in particular the effect of free electrons generated by laser–molecule interaction, several heuristic models, such as UPPE, HOKE models, etc, coupled with Drude-like models [1, 2], were derived. The goal of this paper is to present alternative approaches based on non-heuristic principles. This work is in particular motivated by the on-going debate in the filamentation community, about the effect of high order nonlinearities versus plasma effects due to free electrons, in pulse defocusing occurring in laser filaments [3–9]. The motivation of our work goes beyond filamentation modeling, and is more generally related to the interaction of any external intense and (short) pulse with a gas. In this paper, two different strategies are developed. The first one is based on the derivation of an evolution equation on the polarization, in order to determine the response of the medium (polarization) subject to a short and intense electromagnetic field. Then, we derive a combined semi-heuristic model, based on Lewenstein’s strong field approximation model and the usual perturbative modeling in nonlinear optics. The proposed model allows for inclusion of high order nonlinearities as well as free electron plasma effects. (paper)

  17. Heeding the waveform inversion nonlinearity by unwrapping the model and data

    KAUST Repository

    Alkhalifah, Tariq Ali

    2012-01-01

    Unlike traveltime inversion, waveform inversion provides relatively higher-resolution inverted models. This feature, however, comes at the cost of introducing complex nonlinearity to the inversion operator complicating the convergence process. We use unwrapped-phase-based objective functions to reduce such nonlinearity in a domain in which the high-frequency component is given by the traveltime inversion. Such information is packaged in a frequency-dependent attribute (or traveltime) that can be easily manipulated at different frequencies. It unwraps the phase of the wavefield yielding far less nonlinearity in the objective function than those experienced with the conventional misfit objective function, and yet it still holds most of the critical waveform information in its frequency dependency. However, it suffers from nonlinearity introduced by the model (or reflectivity), as events interact with each other (something like cross talk). This stems from the sinusoidal nature of the band-limited reflectivity model. Unwrapping the phase for such a model can mitigate this nonlinearity as well. Specifically, a simple modification to the inverted domain (or model), can reduce the effect of the model-induced nonlinearity and, thus, make the inversion more convergent. Simple examples are used to highlight such features.

  18. Model-free inference of direct network interactions from nonlinear collective dynamics.

    Science.gov (United States)

    Casadiego, Jose; Nitzan, Mor; Hallerberg, Sarah; Timme, Marc

    2017-12-19

    The topology of interactions in network dynamical systems fundamentally underlies their function. Accelerating technological progress creates massively available data about collective nonlinear dynamics in physical, biological, and technological systems. Detecting direct interaction patterns from those dynamics still constitutes a major open problem. In particular, current nonlinear dynamics approaches mostly require to know a priori a model of the (often high dimensional) system dynamics. Here we develop a model-independent framework for inferring direct interactions solely from recording the nonlinear collective dynamics generated. Introducing an explicit dependency matrix in combination with a block-orthogonal regression algorithm, the approach works reliably across many dynamical regimes, including transient dynamics toward steady states, periodic and non-periodic dynamics, and chaos. Together with its capabilities to reveal network (two point) as well as hypernetwork (e.g., three point) interactions, this framework may thus open up nonlinear dynamics options of inferring direct interaction patterns across systems where no model is known.

  19. Geometrical nonlinear deformation model and its experimental study on bimorph giant magnetostrictive thin film

    Institute of Scientific and Technical Information of China (English)

    Wei LIU; Zhenyuan JIA; Fuji WANG; Yongshun ZHANG; Dongming GUO

    2008-01-01

    The geometrical nonlinearity of a giant magne-tostrictive thin film (GMF) can be clearly detected under the magnetostriction effect. Thus, using geometrical linear elastic theory to describe the strain, stress, and constitutive relationship of GMF is inaccurate. According to nonlinear elastic theory, a nonlinear deformation model of the bimorph GMF is established based on assumptions that the magnetostriction effect is equivalent to the effect of body force loaded on the GMF. With Taylor series method, the numerical solution is deduced. Experiments on TbDyFe/Polyimide (PI)/SmFe and TbDyFe/Cu/SmFe are then conducted to verify the proposed model, respectively. Results indicate that the nonlinear deflection curve model is in good conformity with the experimental data.

  20. Exact solutions to a nonlinear dispersive model with variable coefficients

    International Nuclear Information System (INIS)

    Yin Jun; Lai Shaoyong; Qing Yin

    2009-01-01

    A mathematical technique based on an auxiliary differential equation and the symbolic computation system Maple is employed to investigate a prototypical and nonlinear K(n, n) equation with variable coefficients. The exact solutions to the equation are constructed analytically under various circumstances. It is shown that the variable coefficients and the exponent appearing in the equation determine the quantitative change in the physical structures of the solutions.